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Sample records for multiple comparisons test

  1. Kruskal-Wallis Test in Multiple Comparisons

    Parys, Dariusz

    2009-01-01

    In this paper we show that the Kruskal-Wallis test can be transform to quadratic form among the Mann-Whitney or Kendal τ au concordance measures between pairs of treatments. A multiple comparisons procedure based on patterns of transitive ordering among treatments is implement. We also consider the circularity and non-transitive effects. Statystyka testu Kruskala-Wallisa przedstawiona jest w postaci formy kwadratowej z użyciem statystyki Manna-Whitneya lub miar konkordacji τ au Kendalla. N...

  2. A Comparison of Single-Cycle Versus Multiple-Cycle Proof Testing Strategies

    McClung, R. C.; Chell, G. G.; Millwater, H. R.; Russell, D. A.; Millwater, H. R.

    1999-01-01

    Single-cycle and multiple-cycle proof testing (SCPT and MCPT) strategies for reusable aerospace propulsion system components are critically evaluated and compared from a rigorous elastic-plastic fracture mechanics perspective. Earlier MCPT studies are briefly reviewed. New J-integral estimation methods for semielliptical surface cracks and cracks at notches are derived and validated. Engineering methods are developed to characterize crack growth rates during elastic-plastic fatigue crack growth (FCG) and the tear-fatigue interaction near instability. Surface crack growth experiments are conducted with Inconel 718 to characterize tearing resistance, FCG under small-scale yielding and elastic-plastic conditions, and crack growth during simulated MCPT. Fractography and acoustic emission studies provide additional insight. The relative merits of SCPT and MCPT are directly compared using a probabilistic analysis linked with an elastic-plastic crack growth computer code. The conditional probability of failure in service is computed for a population of components that have survived a previous proof test, based on an assumed distribution of initial crack depths. Parameter studies investigate the influence of proof factor, tearing resistance, crack shape, initial crack depth distribution, and notches on the MCPT versus SCPT comparison. The parameter studies provide a rational basis to formulate conclusions about the relative advantages and disadvantages of SCPT and MCPT. Practical engineering guidelines are proposed to help select the optimum proof test protocol in a given application.

  3. A SAS(®) macro implementation of a multiple comparison post hoc test for a Kruskal-Wallis analysis.

    Elliott, Alan C; Hynan, Linda S

    2011-04-01

    The Kruskal-Wallis (KW) nonparametric analysis of variance is often used instead of a standard one-way ANOVA when data are from a suspected non-normal population. The KW omnibus procedure tests for some differences between groups, but provides no specific post hoc pair wise comparisons. This paper provides a SAS(®) macro implementation of a multiple comparison test based on significant Kruskal-Wallis results from the SAS NPAR1WAY procedure. The implementation is designed for up to 20 groups at a user-specified alpha significance level. A Monte-Carlo simulation compared this nonparametric procedure to commonly used parametric multiple comparison tests. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  4. Comparison of Force and Moment Coefficients for the Same Test Article in Multiple Wind Tunnels

    Deloach, Richard

    2013-01-01

    This paper compares the results of force and moment measurements made on the same test article and with the same balance in three transonic wind tunnels. Comparisons are made for the same combination of Reynolds number, Mach number, sideslip angle, control surface configuration, and angle of attack range. Between-tunnel force and moment differences are quantified. An analysis of variance was performed at four unique sites in the design space to assess the statistical significance of between-tunnel variation and any interaction with angle of attack. Tunnel to tunnel differences too large to attribute to random error were detected were observed for all forces and moments. In some cases these differences were independent of angle of attack and in other cases they changed with angle of attack.

  5. Comparison and clinical utility evaluation of four multiple allergen simultaneous tests including two newly introduced fully automated analyzers

    John Hoon Rim

    2016-04-01

    Full Text Available Background: We compared the diagnostic performances of two newly introduced fully automated multiple allergen simultaneous tests (MAST analyzers with two conventional MAST assays. Methods: The serum samples from a total of 53 and 104 patients were tested for food panels and inhalant panels, respectively, in four analyzers including AdvanSure AlloScreen (LG Life Science, Korea, AdvanSure Allostation Smart II (LG Life Science, PROTIA Allergy-Q (ProteomeTech, Korea, and RIDA Allergy Screen (R-Biopharm, Germany. We compared not only the total agreement percentages but also positive propensities among four analyzers. Results: Evaluation of AdvanSure Allostation Smart II as upgraded version of AdvanSure AlloScreen revealed good concordance with total agreement percentages of 93.0% and 92.2% in food and inhalant panel, respectively. Comparisons of AdvanSure Allostation Smart II or PROTIA Allergy-Q with RIDA Allergy Screen also showed good concordance performance with positive propensities of two new analyzers for common allergens (Dermatophagoides farina and Dermatophagoides pteronyssinus. The changes of cut-off level resulted in various total agreement percentage fluctuations among allergens by different analyzers, although current cut-off level of class 2 appeared to be generally suitable. Conclusions: AdvanSure Allostation Smart II and PROTIA Allergy-Q presented favorable agreement performances with RIDA Allergy Screen, although positive propensities were noticed in common allergens. Keywords: Multiple allergen simultaneous test, Automated analyzer

  6. Multiple comparisons permutation test for image based data mining in radiotherapy

    Chen, Chun; Witte, Marnix; Heemsbergen, Wilma; van Herk, Marcel

    2013-01-01

    : Comparing incidental dose distributions (i.e. images) of patients with different outcomes is a straightforward way to explore dose-response hypotheses in radiotherapy. In this paper, we introduced a permutation test that compares images, such as dose distributions from radiotherapy, while tackling

  7. Comparison between three option, four option and five option multiple choice question tests for quality parameters: A randomized study.

    Vegada, Bhavisha; Shukla, Apexa; Khilnani, Ajeetkumar; Charan, Jaykaran; Desai, Chetna

    2016-01-01

    Most of the academic teachers use four or five options per item of multiple choice question (MCQ) test as formative and summative assessment. Optimal number of options in MCQ item is a matter of considerable debate among academic teachers of various educational fields. There is a scarcity of the published literature regarding the optimum number of option in each item of MCQ in the field of medical education. To compare three options, four options, and five options MCQs test for the quality parameters - reliability, validity, item analysis, distracter analysis, and time analysis. Participants were 3 rd semester M.B.B.S. students. Students were divided randomly into three groups. Each group was given one set of MCQ test out of three options, four options, and five option randomly. Following the marking of the multiple choice tests, the participants' option selections were analyzed and comparisons were conducted of the mean marks, mean time, validity, reliability and facility value, discrimination index, point biserial value, distracter analysis of three different option formats. Students score more ( P = 0.000) and took less time ( P = 0.009) for the completion of three options as compared to four options and five options groups. Facility value was more ( P = 0.004) in three options group as compared to four and five options groups. There was no significant difference between three groups for the validity, reliability, and item discrimination. Nonfunctioning distracters were more in the four and five options group as compared to three option group. Assessment based on three option MCQs is can be preferred over four option and five option MCQs.

  8. Global testing under sparse alternatives: ANOVA, multiple comparisons and the higher criticism

    Arias-Castro, Ery; Candès, Emmanuel J.; Plan, Yaniv

    2011-01-01

    Testing for the significance of a subset of regression coefficients in a linear model, a staple of statistical analysis, goes back at least to the work of Fisher who introduced the analysis of variance (ANOVA). We study this problem under the assumption that the coefficient vector is sparse, a common situation in modern high-dimensional settings. Suppose we have $p$ covariates and that under the alternative, the response only depends upon the order of $p^{1-\\alpha}$ of those, $0\\le\\alpha\\le1$...

  9. Characterizing the Joint Effect of Diverse Test-Statistic Correlation Structures and Effect Size on False Discovery Rates in a Multiple-Comparison Study of Many Outcome Measures

    Feiveson, Alan H.; Ploutz-Snyder, Robert; Fiedler, James

    2011-01-01

    In their 2009 Annals of Statistics paper, Gavrilov, Benjamini, and Sarkar report the results of a simulation assessing the robustness of their adaptive step-down procedure (GBS) for controlling the false discovery rate (FDR) when normally distributed test statistics are serially correlated. In this study we extend the investigation to the case of multiple comparisons involving correlated non-central t-statistics, in particular when several treatments or time periods are being compared to a control in a repeated-measures design with many dependent outcome measures. In addition, we consider several dependence structures other than serial correlation and illustrate how the FDR depends on the interaction between effect size and the type of correlation structure as indexed by Foerstner s distance metric from an identity. The relationship between the correlation matrix R of the original dependent variables and R, the correlation matrix of associated t-statistics is also studied. In general R depends not only on R, but also on sample size and the signed effect sizes for the multiple comparisons.

  10. Evaluation and Comparison of Multiple Test Methods, Including Real-time PCR, for Legionella Detection in Clinical Specimens

    Peci, Adriana; Winter, Anne-Luise; Gubbay, Jonathan B.

    2016-01-01

    Legionella is a Gram-negative bacterium that can cause Pontiac fever, a mild upper respiratory infection and Legionnaire’s disease, a more severe illness. We aimed to compare the performance of urine antigen, culture, and polymerase chain reaction (PCR) test methods and to determine if sputum is an acceptable alternative to the use of more invasive bronchoalveolar lavage (BAL). Data for this study included specimens tested for Legionella at Public Health Ontario Laboratories from 1st January, 2010 to 30th April, 2014, as part of routine clinical testing. We found sensitivity of urinary antigen test (UAT) compared to culture to be 87%, specificity 94.7%, positive predictive value (PPV) 63.8%, and negative predictive value (NPV) 98.5%. Sensitivity of UAT compared to PCR was 74.7%, specificity 98.3%, PPV 77.7%, and NPV 98.1%. Out of 146 patients who had a Legionella-positive result by PCR, only 66 (45.2%) also had a positive result by culture. Sensitivity for culture was the same using either sputum or BAL (13.6%); sensitivity for PCR was 10.3% for sputum and 12.8% for BAL. Both sputum and BAL yield similar results regardless testing methods (Fisher Exact p-values = 1.0, for each test). In summary, all test methods have inherent weaknesses in identifying Legionella; therefore, more than one testing method should be used. Obtaining a single specimen type from patients with pneumonia limits the ability to diagnose Legionella, particularly when urine is the specimen type submitted. Given ease of collection and similar sensitivity to BAL, clinicians are encouraged to submit sputum in addition to urine when BAL submission is not practical from patients being tested for Legionella. PMID:27630979

  11. Evaluation and comparison of multiple test methods, including real-time PCR, for Legionella detection in clinical specimens.

    Adriana Peci

    2016-08-01

    Full Text Available Legionella is a gram-negative bacterium that can cause Pontiac fever, a mild upper respiratory infection and Legionnaire’s disease, a more severe illness. We aimed to compare the performance of urine antigen, culture and PCR test methods and to determine if sputum is an alternative to the use of more invasive bronchoalveolar lavage (BAL. Data for this study included specimens tested for Legionella at PHOL from January 1, 2010 to April 30, 2014, as part of routine clinical testing. We found sensitivity of UAT compared to culture to be 87%, specificity 94.7%, positive predictive value (PPV 63.8% and negative predictive value (NPV 98.5%. Sensitivity of UAT compared to PCR was 74.7%, specificity 98.3%, PPV 77.7% and NPV 98.1%. Of 146 patients who had a Legionella positive result by PCR, only 66(45.2% also had a positive result by culture. Sensitivity for culture was the same using either sputum or BAL (13.6%; sensitivity for PCR was 10.3% for sputum and 12.8% for BAL. Both sputum and BAL yield similar results despite testing methods (Fisher Exact p-values=1.0, for each test. In summary, all test methods have inherent weaknesses in identifying Legionella; thereforemore than one testing method should be used. Obtaining a single specimen type from patients with pneumonia limits the ability to diagnose Legionella, particularly when urine is the specimen type submitted. Given ease of collection, and similar sensitivity to BAL, clinicians are encouraged to submit sputum in addition to urine when BAL submission is not practical, from patients being tested for Legionella.

  12. Nonparametric Analysis of Right Censored Data with Multiple Comparisons

    Shih, Hwei-Weng

    1982-01-01

    This report demonstrates the use of a computer program written in FORTRAN for the Burroughs B6800 computer at Utah State University to perform Breslow's (1970) generalization of the Kruskal-Wallis test for right censored data. A pairwise multiple comparison procedure using Bonferroni's inequality is also introduced and demonstrated. Comparisons are also made with a parametric F test and the original Kruskal-Wallis test. Application of these techniques to two data sets indicate that there is l...

  13. Comparison of Sleep Latency and Number of SOREMPs in the Home and Hospital With a Modified Multiple Sleep Latency Test: A Randomized Crossover Study.

    Beiske, Kornelia K; Sand, Trond; Rugland, Eyvind; Stavem, Knut

    2017-05-01

    Comparison of mean sleep latencies and number of sleep-onset rapid eye movement periods (SOREMPs) between modified multiple sleep latency test (MSLT) performed in the unattended home and in-hospital laboratory setting. A randomized crossover single-blinded design. Thirty-four subjects referred to MSLT for suspected hypersomnia or narcolepsy were included. Participants were randomized to perform modified MSLT in the unattended home or in the hospital first. Scores in the two settings were compared using Wilcoxon signed-rank test or exact McNemar test. Agreement between home and hospital categorized mean sleep latency and number of SOREMPs was assessed using simple kappa (κ) and proportion agreement. Agreement between home and hospital mean sleep latency was assessed using a Bland-Altman plot and an intraclass correlation coefficient. There was no difference between home and hospital assessment of mean sleep latency (P = 0.86). Two or more SOREMPs were found more frequently on modified MSLTs performed at home compared with those at the hospital (7 and 2, respectively; P = 0.025). Agreement was moderate for categorized sleep latency (κ = 0.53) and fair for categorized SOREMPs (κ = 0.39) in the 2 settings. Analysis of mean sleep latency using intraclass correlation coefficient showed a very good agreement between the two settings. Group mean sleep latency for home modified MSLTs seems to be reliable compared with that for the attended sleep-laboratory setting. Higher rate of SOREMP in the unattended home suggests that napping in a familiar environment facilitates the transition into REM sleep. Further studies are needed to assess the normal limit, sensitivity, and specificity for SOREMP at home before the clinical utility of home-based napping can be determined.

  14. Multiple Improvements of Multiple Imputation Likelihood Ratio Tests

    Chan, Kin Wai; Meng, Xiao-Li

    2017-01-01

    Multiple imputation (MI) inference handles missing data by first properly imputing the missing values $m$ times, and then combining the $m$ analysis results from applying a complete-data procedure to each of the completed datasets. However, the existing method for combining likelihood ratio tests has multiple defects: (i) the combined test statistic can be negative in practice when the reference null distribution is a standard $F$ distribution; (ii) it is not invariant to re-parametrization; ...

  15. Multiple treatment comparisons in epilepsy monotherapy trials

    Chadwick David W

    2007-11-01

    Full Text Available Abstract Background The choice of antiepileptic drug for an individual should be based upon the highest quality evidence regarding potential benefits and harms of the available treatments. Systematic reviews and meta-analysis of randomised controlled trials should be a major source of evidence supporting this decision making process. We summarise all available individual patient data evidence from randomised controlled trials that compared at least two out of eight antiepileptic drugs given as monotherapy. Methods Multiple treatment comparisons from epilepsy monotherapy trials were synthesized in a single stratified Cox regression model adjusted for treatment by epilepsy type interactions and making use of direct and indirect evidence. Primary outcomes were time to treatment failure and time to 12 month remission from seizures. A secondary outcome was time to first seizure. Results Individual patient data for 6418 patients from 20 randomised trials comparing eight antiepileptic drugs were synthesized. For partial onset seizures (4628 (72% patients, lamotrigine, carbamazepine and oxcarbazepine provide the best combination of seizure control and treatment failure. Lamotrigine is clinically superior to all other drugs for treatment failure but estimates suggest a disadvantage compared to carbamazepine for time to 12 month remission [Hazard Ratio (95% Confidence Interval = 0.87(0.73 to 1.04] and time to first seizure [1.29(1.13 to 1.48]. Phenobarbitone may delay time to first seizure [0.77(0.61 to 0.96] but at the expense of increased treatment failure [1.60(1.22 to 2.10]. For generalized onset tonic clonic seizures (1790 (28% patients estimates suggest valproate or phenytoin may provide the best combination of seizure control and treatment failure but some uncertainty remains about the relative effectiveness of other drugs. Conclusion For patients with partial onset seizures, results favour carbamazepine, oxcarbazepine and lamotrigine. For

  16. Social attribution test--multiple choice (SAT-MC) in schizophrenia: comparison with community sample and relationship to neurocognitive, social cognitive and symptom measures.

    Bell, Morris D; Fiszdon, Joanna M; Greig, Tamasine C; Wexler, Bruce E

    2010-09-01

    This is the first report on the use of the Social Attribution Task - Multiple Choice (SAT-MC) to assess social cognitive impairments in schizophrenia. The SAT-MC was originally developed for autism research, and consists of a 64-second animation showing geometric figures enacting a social drama, with 19 multiple choice questions about the interactions. Responses from 85 community-dwelling participants and 66 participants with SCID confirmed schizophrenia or schizoaffective disorders (Scz) revealed highly significant group differences. When the two samples were combined, SAT-MC scores were significantly correlated with other social cognitive measures, including measures of affect recognition, theory of mind, self-report of egocentricity and the Social Cognition Index from the MATRICS battery. Using a cut-off score, 53% of Scz were significantly impaired on SAT-MC compared with 9% of the community sample. Most Scz participants with impairment on SAT-MC also had impairment on affect recognition. Significant correlations were also found with neurocognitive measures but with less dependence on verbal processes than other social cognitive measures. Logistic regression using SAT-MC scores correctly classified 75% of both samples. Results suggest that this measure may have promise, but alternative versions will be needed before it can be used in pre-post or longitudinal designs. (c) 2009 Elsevier B.V. All rights reserved.

  17. Common pitfalls in statistical analysis: The perils of multiple testing

    Ranganathan, Priya; Pramesh, C. S.; Buyse, Marc

    2016-01-01

    Multiple testing refers to situations where a dataset is subjected to statistical testing multiple times - either at multiple time-points or through multiple subgroups or for multiple end-points. This amplifies the probability of a false-positive finding. In this article, we look at the consequences of multiple testing and explore various methods to deal with this issue. PMID:27141478

  18. Comparison of physical fitness tests in swimming

    Dostálová, Sabina

    2015-01-01

    Title: Comparison of physical fitness tests in swimming. Objective: The aim of this thesis is to evaluate specific tests, used while testing selected physical abilities in swimming. By specific tests we mean tests realized in the water. Selected tests are intended for swim coaches, who train junior to senior age groups. Methods: The chosen method was a comparison of studies, that pursue selected specific tests. We created partial conclusions for every test by summing up the results of differe...

  19. Direct concurrent comparison of multiple pediatric acute asthma scoring instruments.

    Johnson, Michael D; Nkoy, Flory L; Sheng, Xiaoming; Greene, Tom; Stone, Bryan L; Garvin, Jennifer

    2017-09-01

    Appropriate delivery of Emergency Department (ED) treatment to children with acute asthma requires clinician assessment of acute asthma severity. Various clinical scoring instruments exist to standardize assessment of acute asthma severity in the ED, but their selection remains arbitrary due to few published direct comparisons of their properties. Our objective was to test the feasibility of directly comparing properties of multiple scoring instruments in a pediatric ED. Using a novel approach supported by a composite data collection form, clinicians categorized elements of five scoring instruments before and after initial treatment for 48 patients 2-18 years of age with acute asthma seen at the ED of a tertiary care pediatric hospital ED from August to December 2014. Scoring instruments were compared for inter-rater reliability between clinician types and their ability to predict hospitalization. Inter-rater reliability between clinician types was not different between instruments at any point and was lower (weighted kappa range 0.21-0.55) than values reported elsewhere. Predictive ability of most instruments for hospitalization was higher after treatment than before treatment (p < 0.05) and may vary between instruments after treatment (p = 0.054). We demonstrate the feasibility of comparing multiple clinical scoring instruments simultaneously in ED clinical practice. Scoring instruments had higher predictive ability for hospitalization after treatment than before treatment and may differ in their predictive ability after initial treatment. Definitive conclusions about the best instrument or meaningful comparison between instruments will require a study with a larger sample size.

  20. CCD Photometry Using Multiple Comparison Stars

    Yonggi Kim

    2004-09-01

    Full Text Available The accuracy of CCD observations obtained at the Korean 1.8 m telescope has been studied. Seventeen comparison stars in the vicinity of the cataclysmic variable BG CMi have been measured. The ``artificial" star has been used instead of the ``control" star, what made possible to increase accuracy estimates by a factor of 1.3-2.1 times for ``good" and ``cloudy" nights, respectively. The algorithm of iterative determination of accuracy and weights of few comparison stars contributing to the artificial star, has been presented. The accuracy estimates for 13-mag stars are around 0.002 m mag for exposure times of 30 sec.

  1. Ordinal Welfare Comparisons with Multiple Discrete Indicators

    Arndt, Channing; Distante, Roberta; Hussain, M. Azhar

    We develop an ordinal method for making welfare comparisons between populations with multidimensional discrete well-being indicators observed at the micro level. The approach assumes that, for each well-being indicator, the levels can be ranked from worse to better; however, no assumptions are made...

  2. The positive and negative consequences of multiple-choice testing.

    Roediger, Henry L; Marsh, Elizabeth J

    2005-09-01

    Multiple-choice tests are commonly used in educational settings but with unknown effects on students' knowledge. The authors examined the consequences of taking a multiple-choice test on a later general knowledge test in which students were warned not to guess. A large positive testing effect was obtained: Prior testing of facts aided final cued-recall performance. However, prior testing also had negative consequences. Prior reading of a greater number of multiple-choice lures decreased the positive testing effect and increased production of multiple-choice lures as incorrect answers on the final test. Multiple-choice testing may inadvertently lead to the creation of false knowledge.

  3. Automating Test Activities: Test Cases Creation, Test Execution, and Test Reporting with Multiple Test Automation Tools

    Loke Mun Sei

    2015-01-01

    Software testing has become a mandatory process in assuring the software product quality. Hence, test management is needed in order to manage the test activities conducted in the software test life cycle. This paper discusses on the challenges faced in the software test life cycle, and how the test processes and test activities, mainly on test cases creation, test execution, and test reporting is being managed and automated using several test automation tools, i.e. Jira, ...

  4. Comparison test of electronic dosemeters

    Butterweck, G.; Zimmerli, H.P.; Wernli, C.

    2001-01-01

    To assist with a planned purchase of electronic dosemeters by the Swiss Federal Office for Civil Protection, the calibration laboratory of the Paul Scherrer Institute performed tests on 11 types of electronic dosemeters manufactured by 10 European and American companies. The technical specifications for the World Trade Organisation (WTO) tendering procedure were largely in accord with the specifications of the international standard IEC 61526. First tests were performed with samples from each type of dosemeter. The reproducibility of a dose of 0.1 mSv generated with 137 Cs radiation at a dose rate of 2.1 mSv.h -1 was found adequate for all tested dosemeter types. The response for environmental levels of radiation showed a large variation, indicating insufficient background correction of some dosemeters. A very high dose rate of 10 Sv.h -1 provoked faulty dose readings for more than half of the tested dosemeters. Dosemeter response for low-energy photon radiation was satisfactory for two of the tested dosemeter types. Four dosemeter types were selected for extended technical tests. Three samples of each of these dosemeter types were purchased. For drop and temperature tests the specifications of the WTO tendering procedure outranged the specification of the IEC standard. Whereas even at a temperature of -25 deg. C the tested dosemeters functioned normally, drops from a height of 2 m onto a wooden surface rendered the samples of two dosemeter types inoperative. (author)

  5. A Fiducial Approach to Extremes and Multiple Comparisons

    Wandler, Damian V.

    2010-01-01

    Generalized fiducial inference is a powerful tool for many difficult problems. Based on an extension of R. A. Fisher's work, we used generalized fiducial inference for two extreme value problems and a multiple comparison procedure. The first extreme value problem is dealing with the generalized Pareto distribution. The generalized Pareto…

  6. Multiple Site Damage in Flat Panel Testing

    Shrage, Daniel

    2000-01-01

    This report aimed to experimentally verify analytical models that predict the residual strength of representative aircraft structures, such as wide panels, that are subjected to Multiple Site Damage (MSD...

  7. A test for the parameters of multiple linear regression models ...

    A test for the parameters of multiple linear regression models is developed for conducting tests simultaneously on all the parameters of multiple linear regression models. The test is robust relative to the assumptions of homogeneity of variances and absence of serial correlation of the classical F-test. Under certain null and ...

  8. A Comparison of Three Tests of Mediation

    Warbasse, Rosalia E.

    2009-01-01

    A simulation study was conducted to evaluate the performance of three tests of mediation: the bias-corrected and accelerated bootstrap (Efron & Tibshirani, 1993), the asymmetric confidence limits test (MacKinnon, 2008), and a multiple regression approach described by Kenny, Kashy, and Bolger (1998). The evolution of these methods is reviewed and…

  9. The Multiple Tasks Test: development and normal strategies.

    Bloem, B.R.; Valkenburg, V.V.; Slabbekoorn, M.; Willemsen, M.D.

    2001-01-01

    Simultaneous challenge of posture and cognition ("dual tasks") may predict falls better than tests of isolated components of postural control. We describe a new balance test (the Multiple Tasks Test, MTT) which (1) is based upon simultaneous assessment of multiple (>2) postural components; (2)

  10. Optimizing Multiple-Choice Tests as Learning Events

    Little, Jeri Lynn

    2011-01-01

    Although generally used for assessment, tests can also serve as tools for learning--but different test formats may not be equally beneficial. Specifically, research has shown multiple-choice tests to be less effective than cued-recall tests in improving the later retention of the tested information (e.g., see meta-analysis by Hamaker, 1986),…

  11. Feedback enhances the positive effects and reduces the negative effects of multiple-choice testing.

    Butler, Andrew C; Roediger, Henry L

    2008-04-01

    Multiple-choice tests are used frequently in higher education without much consideration of the impact this form of assessment has on learning. Multiple-choice testing enhances retention of the material tested (the testing effect); however, unlike other tests, multiple-choice can also be detrimental because it exposes students to misinformation in the form of lures. The selection of lures can lead students to acquire false knowledge (Roediger & Marsh, 2005). The present research investigated whether feedback could be used to boost the positive effects and reduce the negative effects of multiple-choice testing. Subjects studied passages and then received a multiple-choice test with immediate feedback, delayed feedback, or no feedback. In comparison with the no-feedback condition, both immediate and delayed feedback increased the proportion of correct responses and reduced the proportion of intrusions (i.e., lure responses from the initial multiple-choice test) on a delayed cued recall test. Educators should provide feedback when using multiple-choice tests.

  12. Multiple Choice Testing and the Retrieval Hypothesis of the Testing Effect

    Sensenig, Amanda E.

    2010-01-01

    Taking a test often leads to enhanced later memory for the tested information, a phenomenon known as the "testing effect". This memory advantage has been reliably demonstrated with recall tests but not multiple choice tests. One potential explanation for this finding is that multiple choice tests do not rely on retrieval processes to the same…

  13. A Review of Multiple Hypothesis Testing in Otolaryngology Literature

    Kirkham, Erin M.; Weaver, Edward M.

    2018-01-01

    Objective Multiple hypothesis testing (or multiple testing) refers to testing more than one hypothesis within a single analysis, and can inflate the Type I error rate (false positives) within a study. The aim of this review was to quantify multiple testing in recent large clinical studies in the otolaryngology literature and to discuss strategies to address this potential problem. Data sources Original clinical research articles with >100 subjects published in 2012 in the four general otolaryngology journals with the highest Journal Citation Reports 5-year impact factors. Review methods Articles were reviewed to determine whether the authors tested greater than five hypotheses in at least one family of inferences. For the articles meeting this criterion for multiple testing, Type I error rates were calculated and statistical correction was applied to the reported results. Results Of the 195 original clinical research articles reviewed, 72% met the criterion for multiple testing. Within these studies, there was a mean 41% chance of a Type I error and, on average, 18% of significant results were likely to be false positives. After the Bonferroni correction was applied, only 57% of significant results reported within the articles remained significant. Conclusion Multiple testing is common in recent large clinical studies in otolaryngology and deserves closer attention from researchers, reviewers and editors. Strategies for adjusting for multiple testing are discussed. PMID:25111574

  14. Accelerated spike resampling for accurate multiple testing controls.

    Harrison, Matthew T

    2013-02-01

    Controlling for multiple hypothesis tests using standard spike resampling techniques often requires prohibitive amounts of computation. Importance sampling techniques can be used to accelerate the computation. The general theory is presented, along with specific examples for testing differences across conditions using permutation tests and for testing pairwise synchrony and precise lagged-correlation between many simultaneously recorded spike trains using interval jitter.

  15. A new bootstrap test for multiple assets joint risk testing

    Ardia, David; Gatarek, Lukasz; Hoogerheide, Lennart F.

    2017-01-01

    In this paper, a novel simulation-based methodology is proposed to test the validity of a set of marginal time series models, where the dependence structure between the time series is taken directly from the observed data. The procedure is useful when one wants to summarize the test results for

  16. Quantitative comparison of the results obtained by the multiple-dose guinea pig maximization test and the non-radioactive murine local lymph-node assay for various biocides.

    Yamano, Tetsuo; Shimizu, Mitsuru; Noda, Tsutomu

    2005-07-01

    We compared the results of the multiple-dose guinea pig maximization test (GPMT) and the non-radioactive murine local lymph-node assay (LLNA) for various biocides. Thirteen out of 17 positive biocides in the GPMT gave positive results in the LLNA. In the GPMT, the minimum first induction doses ranged over four orders (0.00005-0.5%), while elicitation-threshold doses, which were evaluated using an optimally sensitized group of animals in the multiple-dose studies, ranged over five orders (0.00006-2.8%). In the LLNA, minimum induction doses ranged over more than three orders (0.01-30%). With respect to 13 biocides that were positive in both the GPMT and the LLNA, results were quantitatively compared. When compared after conversion to corresponding area doses (microg/cm), the minimum doses required to elicit skin reaction in guinea pigs were always lower than that for induction in mice with all biocides. Correlation between minimum induction doses from the GPMT and the LLNA seemed poor (r=0.57), while that between minimum induction doses in the LLNA and elicitation-threshold doses in the GPMT was relatively good (r=0.73). The results suggest the possibility to estimate human elicitation-threshold doses, which are definitely lacking in the process of risk assessment for skin-sensitizers, from the data of the LLNA.

  17. Quantitative comparison of the results obtained by the multiple-dose guinea pig maximization test and the non-radioactive murine local lymph-node assay for various biocides

    Yamano, Tetsuo; Shimizu, Mitsuru; Noda, Tsutomu

    2005-01-01

    We compared the results of the multiple-dose guinea pig maximization test (GPMT) and the non-radioactive murine local lymph-node assay (LLNA) for various biocides. Thirteen out of 17 positive biocides in the GPMT gave positive results in the LLNA. In the GPMT, the minimum first induction doses ranged over four orders (0.00005-0.5%), while elicitation-threshold doses, which were evaluated using an optimally sensitized group of animals in the multiple-dose studies, ranged over five orders (0.00006-2.8%). In the LLNA, minimum induction doses ranged over more than three orders (0.01-30%). With respect to 13 biocides that were positive in both the GPMT and the LLNA, results were quantitatively compared. When compared after conversion to corresponding area doses (μg/cm), the minimum doses required to elicit skin reaction in guinea pigs were always lower than that for induction in mice with all biocides. Correlation between minimum induction doses from the GPMT and the LLNA seemed poor (r = 0.57), while that between minimum induction doses in the LLNA and elicitation-threshold doses in the GPMT was relatively good (r = 0.73). The results suggest the possibility to estimate human elicitation-threshold doses, which are definitely lacking in the process of risk assessment for skin-sensitizers, from the data of the LLNA

  18. Advances in ranking and selection, multiple comparisons, and reliability methodology and applications

    Balakrishnan, N; Nagaraja, HN

    2007-01-01

    S. Panchapakesan has made significant contributions to ranking and selection and has published in many other areas of statistics, including order statistics, reliability theory, stochastic inequalities, and inference. Written in his honor, the twenty invited articles in this volume reflect recent advances in these areas and form a tribute to Panchapakesan's influence and impact on these areas. Thematically organized, the chapters cover a broad range of topics from: Inference; Ranking and Selection; Multiple Comparisons and Tests; Agreement Assessment; Reliability; and Biostatistics. Featuring

  19. Comparison of reconfigurable structures for flexible word-length multiplication

    O. A. Pfänder

    2008-05-01

    Full Text Available Binary multiplication continues to be one of the essential arithmetic operations in digital circuits. Even though field-programmable gate arrays (FPGAs are becoming more and more powerful these days, the vendors cannot avoid implementing multiplications with high word-lengths using embedded blocks instead of configurable logic. But on the other hand, the circuit's efficiency decreases if the provided word-length of the hard-wired multipliers exceeds the precision requirements of the algorithm mapped into the FPGA. Thus it is beneficial to use multiplier blocks with configurable word-length, optimized for area, speed and power dissipation, e.g. regarding digital signal processing (DSP applications.

    In this contribution, we present different approaches and structures for the realization of a multiplication with variable precision and perform an objective comparison. This includes one approach based on a modified Baugh and Wooley algorithm and three structures using Booth's arithmetic operand recoding with different array structures. All modules have the option to compute signed two's complement fix-point numbers either as an individual computing unit or interconnected to a superior array. Therefore, a high throughput at low precision through parallelism, or a high precision through concatenation can be achieved.

  20. General solutions to multiple testing problems. Translation of "Sonnemann, E. (1982). Allgemeine Lösungen multipler Test probleme. EDV in Medizin und Biologie 13(4), 120-128".

    Sonnemann, Eckart

    2008-10-01

    The introduction of sequentially rejective multiple test procedures (Einot and Gabriel, 1975; Naik, 1975; Holm, 1977; Holm, 1979) has caused considerable progress in the theory of multiple comparisons. Emphasizing the closure of multiple tests we give a survey of the general theory and its recent results in applications. Some new applications are given including a discussion of the connection with the theory of confidence regions.

  1. Testing for Nonuniform Differential Item Functioning with Multiple Indicator Multiple Cause Models

    Woods, Carol M.; Grimm, Kevin J.

    2011-01-01

    In extant literature, multiple indicator multiple cause (MIMIC) models have been presented for identifying items that display uniform differential item functioning (DIF) only, not nonuniform DIF. This article addresses, for apparently the first time, the use of MIMIC models for testing both uniform and nonuniform DIF with categorical indicators. A…

  2. Multiple-vent programme to test the pressure suppression system

    Aust, E.; Schwan, H.; Vollbrandt, I.

    1979-01-01

    Three pre-tests with a multiple vent configuration have been performed at the GKSS pressure suppression test facility. First test results indicate significant chugging events with occur periodically with 0.4 to 0.2 Hz. These events appear simultaneously in less than 10 ms at the exit of the three vent pipes and cause pressure pulses in the range of 3 bar. This report gives a short description of the test facility and presents the boundary conditions of the test facility and presents the boundary conditions of the three pre-tests, test results and a first valuation of the experimental informations. (orig.) [de

  3. Optimizing multiple-choice tests as tools for learning.

    Little, Jeri L; Bjork, Elizabeth Ligon

    2015-01-01

    Answering multiple-choice questions with competitive alternatives can enhance performance on a later test, not only on questions about the information previously tested, but also on questions about related information not previously tested-in particular, on questions about information pertaining to the previously incorrect alternatives. In the present research, we assessed a possible explanation for this pattern: When multiple-choice questions contain competitive incorrect alternatives, test-takers are led to retrieve previously studied information pertaining to all of the alternatives in order to discriminate among them and select an answer, with such processing strengthening later access to information associated with both the correct and incorrect alternatives. Supporting this hypothesis, we found enhanced performance on a later cued-recall test for previously nontested questions when their answers had previously appeared as competitive incorrect alternatives in the initial multiple-choice test, but not when they had previously appeared as noncompetitive alternatives. Importantly, however, competitive alternatives were not more likely than noncompetitive alternatives to be intruded as incorrect responses, indicating that a general increased accessibility for previously presented incorrect alternatives could not be the explanation for these results. The present findings, replicated across two experiments (one in which corrective feedback was provided during the initial multiple-choice testing, and one in which it was not), thus strongly suggest that competitive multiple-choice questions can trigger beneficial retrieval processes for both tested and related information, and the results have implications for the effective use of multiple-choice tests as tools for learning.

  4. Accelerated Testing with Multiple Failure Modes under Several Temperature Conditions

    Zongyue Yu

    2014-01-01

    Full Text Available A complicated device may have multiple failure modes, and some of the failure modes are sensitive to low temperatures. To assess the reliability of a product with multiple failure modes, this paper presents an accelerated testing in which both of the high temperatures and the low temperatures are applied. Firstly, an acceleration model based on the Arrhenius model but accounting for the influence of both the high temperatures and low temperatures is proposed. Accordingly, an accelerated testing plan including both the high temperatures and low temperatures is designed, and a statistical analysis method is developed. The reliability function of the product with multiple failure modes under variable working conditions is given by the proposed statistical analysis method. Finally, a numerical example is studied to illustrate the proposed accelerated testing. The results show that the proposed accelerated testing is rather efficient.

  5. Accelerated Testing with Multiple Failure Modes under Several Temperature Conditions

    Zongyue Yu; Zhiqian Ren; Junyong Tao; Xun Chen

    2014-01-01

    A complicated device may have multiple failure modes, and some of the failure modes are sensitive to low temperatures. To assess the reliability of a product with multiple failure modes, this paper presents an accelerated testing in which both of the high temperatures and the low temperatures are applied. Firstly, an acceleration model based on the Arrhenius model but accounting for the influence of both the high temperatures and low temperatures is proposed. Accordingly, an accelerated testi...

  6. Cognitive performance of neuromyelitis optica patients: comparison with multiple sclerosis

    Sandra Vanotti

    2013-06-01

    Full Text Available The aim of the present research was to investigate cognitive pattern of patients with neuromyelitis optica (NMO and to compare it with multiple sclerosis (MS patients' performance. Methods: Fourteen NMO, 14 relapsing remitting multiple sclerosis (RRMS, and 14 healthy control patients participated in the investigation. Neuropsychological functions were evaluated with the Brief Repeatable Neuropsychological Battery for MS; Symbol Digit Modalities Test; Digit Span; and Semantic Fluency. Results: Fifty-seven percent of NMO patients and 42.85% of the MS ones had abnormal performance in at least two cognitive tests. The NMO Group showed abnormal performance in verbal fluency, verbal and visual memories, with greater attention deficits. NMO patients outperformed healthy control in the paced auditory serial addition test (PASAT. However, no difference was found between NMO and RRMS patients. Conclusions: The NMO Group showed more dysfunction in attention and verbal fluencies than in verbal and visual memories. When compared with the MS patients, a similar dysfunction pattern was found. O objetivo da presente pesquisa foi investigar o padrão cognitivo de pacientes com neuromielite óptica (NMO e compará-lo com o desempenho de pacientes com esclerose múltipla (EM. Métodos: Quatorze pacientes com NMO, 14 com esclerose múltipla recorrente remitente (EMRR e 14 participantes do Controle saudáveis participaram da presente investigação. As funções neuropsicológicas foram avaliadas com a Bateria Breve de Testes Neuropsicológicos de Rao, Teste Símbolo Digit e a Fluência Semântica. Resultados: Cinquenta e sete por cento dos pacientes com NMO e 42,85% daqueles com EM apresentaram desempenho anormal em pelo menos dois testes cognitivos. O Grupo NMO apresentarou desempenho anormal na fluência verbal e nas memórias visual e verbal, com maiores déficits de atenção. Pacientes com NMO superaram os controles saudáveis em PASAT. No entanto, não foi

  7. Multiple-choice test of energy and momentum concepts

    Singh, Chandralekha; Rosengrant, David

    2016-01-01

    We investigate student understanding of energy and momentum concepts at the level of introductory physics by designing and administering a 25-item multiple choice test and conducting individual interviews. We find that most students have difficulty in qualitatively interpreting basic principles related to energy and momentum and in applying them in physical situations.

  8. Multiple comparison procedures for neuroimaging genomewide association studies.

    Hua, Wen-Yu; Nichols, Thomas E; Ghosh, Debashis

    2015-01-01

    Recent research in neuroimaging has focused on assessing associations between genetic variants that are measured on a genomewide scale and brain imaging phenotypes. A large number of works in the area apply massively univariate analyses on a genomewide basis to find single nucleotide polymorphisms that influence brain structure. In this paper, we propose using various dimensionality reduction methods on both brain structural MRI scans and genomic data, motivated by the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. We also consider a new multiple testing adjustment method and compare it with two existing false discovery rate (FDR) adjustment methods. The simulation results suggest an increase in power for the proposed method. The real-data analysis suggests that the proposed procedure is able to find associations between genetic variants and brain volume differences that offer potentially new biological insights. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  9. Kernel Machine SNP-set Testing under Multiple Candidate Kernels

    Wu, Michael C.; Maity, Arnab; Lee, Seunggeun; Simmons, Elizabeth M.; Harmon, Quaker E.; Lin, Xinyi; Engel, Stephanie M.; Molldrem, Jeffrey J.; Armistead, Paul M.

    2013-01-01

    Joint testing for the cumulative effect of multiple single nucleotide polymorphisms grouped on the basis of prior biological knowledge has become a popular and powerful strategy for the analysis of large scale genetic association studies. The kernel machine (KM) testing framework is a useful approach that has been proposed for testing associations between multiple genetic variants and many different types of complex traits by comparing pairwise similarity in phenotype between subjects to pairwise similarity in genotype, with similarity in genotype defined via a kernel function. An advantage of the KM framework is its flexibility: choosing different kernel functions allows for different assumptions concerning the underlying model and can allow for improved power. In practice, it is difficult to know which kernel to use a priori since this depends on the unknown underlying trait architecture and selecting the kernel which gives the lowest p-value can lead to inflated type I error. Therefore, we propose practical strategies for KM testing when multiple candidate kernels are present based on constructing composite kernels and based on efficient perturbation procedures. We demonstrate through simulations and real data applications that the procedures protect the type I error rate and can lead to substantially improved power over poor choices of kernels and only modest differences in power versus using the best candidate kernel. PMID:23471868

  10. 42 CFR 493.1281 - Standard: Comparison of test results.

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Comparison of test results. 493.1281 Section 493.1281 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Testing Analytic Systems § 493.1281 Standard: Comparison of test results. (a) If a laboratory performs the...

  11. Conservatism implications of shock test tailoring for multiple design environments

    Baca, Thomas J.; Bell, R. Glenn; Robbins, Susan A.

    1987-01-01

    A method for analyzing shock conservation in test specifications that have been tailored to qualify a structure for multiple design environments is discussed. Shock test conservation is qualified for shock response spectra, shock intensity spectra and ranked peak acceleration data in terms of an Index of Conservation (IOC) and an Overtest Factor (OTF). The multi-environment conservation analysis addresses the issue of both absolute and average conservation. The method is demonstrated in a case where four laboratory tests have been specified to qualify a component which must survive seven different field environments. Final judgment of the tailored test specification is shown to require an understanding of the predominant failure modes of the test item.

  12. Planned Hypothesis Tests Are Not Necessarily Exempt From Multiplicity Adjustment

    Andrew V. Frane

    2015-10-01

    Full Text Available Scientific research often involves testing more than one hypothesis at a time, which can inflate the probability that a Type I error (false discovery will occur. To prevent this Type I error inflation, adjustments can be made to the testing procedure that compensate for the number of tests. Yet many researchers believe that such adjustments are inherently unnecessary if the tests were “planned” (i.e., if the hypotheses were specified before the study began. This longstanding misconception continues to be perpetuated in textbooks and continues to be cited in journal articles to justify disregard for Type I error inflation. I critically evaluate this myth and examine its rationales and variations. To emphasize the myth’s prevalence and relevance in current research practice, I provide examples from popular textbooks and from recent literature. I also make recommendations for improving research practice and pedagogy regarding this problem and regarding multiple testing in general.

  13. Comparisons of Latinos, African Americans, and Caucasians with multiple sclerosis.

    Buchanan, Robert J; Zuniga, Miguel A; Carrillo-Zuniga, Genny; Chakravorty, Bonnie J; Tyry, Tuula; Moreau, Rachel L; Huang, Chunfeng; Vollmer, Timothy

    2010-01-01

    Identify racial/ethnic differences among people with multiple sclerosis (MS) in demographics, MS disease characteristics, and health services received. We analyzed enrollment data from the Registry of the North American Research Committee on Multiple Sclerosis (NARCOMS) Project to compare 26,967 Caucasians, 715 Latinos, and 1,313 African Americans with MS. Racial/ethnic analyses of NARCOMS data focused on descriptive characteristics, using ANOVA and chi-square tests to identify significant differences in means and frequencies among Caucasians, Latinos, and African Americans. We identified significant racial/ethnic differences in demographics, MS disease characteristics, and treatments. Caucasians were older when first MS symptoms were experienced (30.1 years) and at MS diagnosis (37.4 years) than Latinos (28.6 years and 34.5 years) or African Americans (29.8 years and 35.8 years). Larger proportions of Latinos reported normal function for mobility and bladder/bowel function compared to Caucasians. Larger proportions of Latinos (44.2 percent) and African Americans (45.8 percent) reported at least mild depression compared to only 38.7 percent of Caucasians. Larger proportions of Latinos never received mental health care or care from rehabilitation specialists than Caucasians or African Americans. A larger proportion of African Americans had never been treated by a neurologist specializing in MS and a smaller proportion of African Americans received care at a MS clinic than Caucasians or Latinos. Our findings highlight the need for future analyses to determine if age, disease duration, MS symptoms, and disability levels provide additional insights into racial/ethic differences in the use of MS-related providers.

  14. Bees Algorithm for Construction of Multiple Test Forms in E-Testing

    Songmuang, Pokpong; Ueno, Maomi

    2011-01-01

    The purpose of this research is to automatically construct multiple equivalent test forms that have equivalent qualities indicated by test information functions based on item response theory. There has been a trade-off in previous studies between the computational costs and the equivalent qualities of test forms. To alleviate this problem, we…

  15. Analysis of Multiple Choice Tests Designed by Faculty Members of Kermanshah University of Medical Sciences

    Reza Pourmirza Kalhori

    2013-12-01

    Full Text Available Dear Editor Multiple choice tests are the most common objective tests in medical education which are used to assess the ind-ividual knowledge, recall, recognition and problem solving abilities. One of the testing components is the post-test analysis. This component includes; first, qualitative analysis of the taxonomy of questions based on the Bloom’s educational objectives and percentage of the questions with no structural problems; and second, the quantitative analysis of the reliability (KR-20 and indices of difficulty and differentiation (1. This descriptive-analytical study was aimed to qualitatively and quan-titatively investigate the multiple-choice tests of the faculty members at Kermanshah University of Medical Sciences in 2009-2010. The sample size comprised of 156 tests. Data were analyzed by SPSS-16 software using t-test, chi-squared test, ANOVA and Tukey multiple comparison tests. The mean of reliability (KR-20, difficulty index, and discrimination index were 0.68 (± 0.31, 0.56 (± 0.15 and 0.21 (± 0.15, respectively, which were acceptable. The analysis of the tests at Mashad University of Medical Sciences indicated that the mean for the reliability of the tests was 0.72, and 52.2% of the tests had inappropriate difficulty index and 49.2% of the tests did not have acceptable differentiation index (2. Comparison of the tests at Kermanshah University of Medical Sciences for the fields of anatomy, physiology, biochemistry, genetics, statistics and behavioral sciences courses at Malaysia Faculty of Medicine (3 and tests at Argentina Faculty of Medicine (4 showed that while difficulty index was acceptable in all three universities, but differentiation indices in Malaysia and Argentina Medical Faculties were higher than that in Kermanshah University of Medical Sciences. The mean for the questions with no structural flaws in all tests, taxonomy I, taxonomy II, and taxonomy III were 73.88% (± 14.88, 34.65% (± 15.78, 41.34% (± 13

  16. Reliability of psychophysiological responses across multiple motion sickness stimulation tests

    Stout, C. S.; Toscano, W. B.; Cowings, P. S.

    1995-01-01

    Although there is general agreement that a high degree of variability exists between subjects in their autonomic nervous system responses to motion sickness stimulation, very little evidence exists that examines the reproducibility of autonomic responses within subjects during motion sickness stimulation. Our objectives were to examine the reliability of autonomic responses and symptom levels across five testing occasions using the (1) final minute of testing, (2) change in autonomic response and the change in symptom level, and (3) strength of the relationship between the change in symptom level and the change in autonomic responses across the entire motion sickness test. The results indicate that, based on the final minute of testing, the autonomic responses of heart rate, blood volume pulse, and respiration rate are moderately stable across multiple tests. Changes in heart rate, blood volume pulse, respiration rate, and symptoms throughout the test duration are less stable across the tests. Finally, autonomic responses and symptom levels are significantly related across the entire motion sickness test.

  17. Multiple Sources of Test Bias on the WISC-R and Bender-Gestalt Test.

    Oakland, Thomas; Feigenbaum, David

    1979-01-01

    Assessed test bias on the Wechsler Intelligence Test for Children-Revised (WISC-R) and Bender-Gestalt. On the Bender, evidence of bias was infrequent and irregular. On the WISC-R, group differences were most discernible for age, sex, family structure, and race. Consistent patterns of bias were not apparent among comparison groups. (Author)

  18. Integrative set enrichment testing for multiple omics platforms

    Poisson Laila M

    2011-11-01

    Full Text Available Abstract Background Enrichment testing assesses the overall evidence of differential expression behavior of the elements within a defined set. When we have measured many molecular aspects, e.g. gene expression, metabolites, proteins, it is desirable to assess their differential tendencies jointly across platforms using an integrated set enrichment test. In this work we explore the properties of several methods for performing a combined enrichment test using gene expression and metabolomics as the motivating platforms. Results Using two simulation models we explored the properties of several enrichment methods including two novel methods: the logistic regression 2-degree of freedom Wald test and the 2-dimensional permutation p-value for the sum-of-squared statistics test. In relation to their univariate counterparts we find that the joint tests can improve our ability to detect results that are marginal univariately. We also find that joint tests improve the ranking of associated pathways compared to their univariate counterparts. However, there is a risk of Type I error inflation with some methods and self-contained methods lose specificity when the sets are not representative of underlying association. Conclusions In this work we show that consideration of data from multiple platforms, in conjunction with summarization via a priori pathway information, leads to increased power in detection of genomic associations with phenotypes.

  19. Benefits of the Multiple Echo Technique for Ultrasonic Thickness Testing

    Elder, J.; Vandekamp, R.

    2011-02-10

    Much effort has been put into determining methods to make accurate thickness measurements, especially at elevated temperatures. An accuracy of +/- 0.001 inches is typically noted for commercial ultrasonic thickness gauges and ultrasonic thickness techniques. Codes and standards put limitations on many inspection factors including equipment, calibration tolerance and temperature variations. These factors are important and should be controlled, but unfortunately do not guarantee accurate and repeatable measurements in the field. Most technicians long for a single technique that is best for every situation, unfortunately, there are no 'silver bullets' when it comes to nondestructive testing. This paper will describe and discuss some of the major contributors to measurement error as well as some advantages and limitations of multiple echo techniques and why multiple echo techniques should be more widely utilized for ultrasonic thickness measurements.

  20. Training in multiple breath washout testing for respiratory physiotherapists.

    O'Neill, Katherine; Elborn, J Stuart; Tunney, Michael M; O'Neill, Philip; Rowan, Stephen; Martin, Susan; Bradley, Judy M

    2018-03-01

    The development of multiple breath washout (MBW) testing in respiratory disease highlights the need for increased awareness amongst respiratory physiotherapists and a potential opportunity for professional development in the use of an important outcome measure for clinical trials. To rationalise how MBW may be a useful assessment tool for respiratory physiotherapists and to describe a local MBW training and certification programme for physiotherapists. The respiratory Multidisciplinary Team in the Belfast Health and Social Care Trust (BHSCT) identified a need for MBW testing to be available to facilitate clinical research and assessment. A 2day training programme consisting of prereading preparation, self-directed learning, theory presentations, practical demonstrations and hands-on practice was developed and delivered. All participants underwent a certification process. We have demonstrated the successful training and certification of clinical and research physiotherapists and encourage other respiratory physiotherapists to consider MBW test training. Copyright © 2017 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

  1. Operation of a nuclear test gage at low multiplications

    Baumann, N.P.

    1977-01-01

    The Nuclear Test Gage (NTG) at the Savannah River Plant is a subcritical multiplying facility (low k) with H 2 O moderator and 2.54-cm-diameter fuel slugs of 5 wt percent 235 U in aluminum alloy at a 4.285-cm triangular pitch. The core of the facility is 61-cm long with a normal diameter of 27 cm. The NTG is used for quality control of reactor components, such as 235 U-Al fuel tubes, Li--Al target tubes, control and safety rods, and miscellaneous special irradiation elements. A component is tested by passing it through an axial test port 11.63 cm in diameter. The ion chamber response from the resultant change in neutron source multiplication is then compared with corresponding responses from known standards

  2. Comparison of test protocols for standard room/corner tests

    R. H. White; M. A. Dietenberger; H. Tran; O. Grexa; L. Richardson; K. Sumathipala; M. Janssens

    1998-01-01

    As part of international efforts to evaluate alternative reaction-to-fire tests, several series of room/comer tests have been conducted. This paper reviews the overall results of related projects in which different test protocols for standard room/corner tests were used. Differences in the test protocols involved two options for the ignition burner scenario and whether...

  3. A Spreadsheet Tool for Learning the Multiple Regression F-Test, T-Tests, and Multicollinearity

    Martin, David

    2008-01-01

    This note presents a spreadsheet tool that allows teachers the opportunity to guide students towards answering on their own questions related to the multiple regression F-test, the t-tests, and multicollinearity. The note demonstrates approaches for using the spreadsheet that might be appropriate for three different levels of statistics classes,…

  4. Effects of dependence in high-dimensional multiple testing problems

    van de Wiel Mark A

    2008-02-01

    Full Text Available Abstract Background We consider effects of dependence among variables of high-dimensional data in multiple hypothesis testing problems, in particular the False Discovery Rate (FDR control procedures. Recent simulation studies consider only simple correlation structures among variables, which is hardly inspired by real data features. Our aim is to systematically study effects of several network features like sparsity and correlation strength by imposing dependence structures among variables using random correlation matrices. Results We study the robustness against dependence of several FDR procedures that are popular in microarray studies, such as Benjamin-Hochberg FDR, Storey's q-value, SAM and resampling based FDR procedures. False Non-discovery Rates and estimates of the number of null hypotheses are computed from those methods and compared. Our simulation study shows that methods such as SAM and the q-value do not adequately control the FDR to the level claimed under dependence conditions. On the other hand, the adaptive Benjamini-Hochberg procedure seems to be most robust while remaining conservative. Finally, the estimates of the number of true null hypotheses under various dependence conditions are variable. Conclusion We discuss a new method for efficient guided simulation of dependent data, which satisfy imposed network constraints as conditional independence structures. Our simulation set-up allows for a structural study of the effect of dependencies on multiple testing criterions and is useful for testing a potentially new method on π0 or FDR estimation in a dependency context.

  5. A Powerful Test for Comparing Multiple Regression Functions.

    Maity, Arnab

    2012-09-01

    In this article, we address the important problem of comparison of two or more population regression functions. Recently, Pardo-Fernández, Van Keilegom and González-Manteiga (2007) developed test statistics for simple nonparametric regression models: Y(ij) = θ(j)(Z(ij)) + σ(j)(Z(ij))∊(ij), based on empirical distributions of the errors in each population j = 1, … , J. In this paper, we propose a test for equality of the θ(j)(·) based on the concept of generalized likelihood ratio type statistics. We also generalize our test for other nonparametric regression setups, e.g, nonparametric logistic regression, where the loglikelihood for population j is any general smooth function [Formula: see text]. We describe a resampling procedure to obtain the critical values of the test. In addition, we present a simulation study to evaluate the performance of the proposed test and compare our results to those in Pardo-Fernández et al. (2007).

  6. Inherent variation in multiple shoe-sole test impressions.

    Shor, Yaron; Wiesner, Sarena; Tsach, Tsadok; Gurel, Ron; Yekutieli, Yoram

    2018-04-01

    Shoeprints left at crime scenes are seldom perfect. Many prints are distorted or contaminated by various materials. Noisy background often contributes to vagueness on the shoeprints as well. Test impressions made from the suspect's shoes in the laboratory are considered a genuine replication of the shoe-sole. This naïve attitude is far from being correct. Consecutive test impressions made in the laboratory under strict similar conditions revealed differences among the exemplars of the same sole. Some of them are minor, but some are major, and can mislead the less experienced practitioners during the comparison process. This article focuses on the inherent within source variability between controlled shoeprints made from the same shoe, as it appears on the RACs. To describe and analyze this variability, repeated test impressions were prepared, and datasets were created. Several RACs were marked on each test impression, using an expert assisting software tool (developed in the authors' lab). The variance in repeated test impressions is demonstrated and possible sources are discussed. This variance should be considered when trying to establish the degree of matching between individual characteristics. Copyright © 2017. Published by Elsevier B.V.

  7. Testing multiple coordination constraints with a novel bimanual visuomotor task.

    Helene M Sisti

    Full Text Available The acquisition of a new bimanual skill depends on several motor coordination constraints. To date, coordination constraints have often been tested relatively independently of one another, particularly with respect to isofrequency and multifrequency rhythms. Here, we used a new paradigm to test the interaction of multiple coordination constraints. Coordination constraints that were tested included temporal complexity, directionality, muscle grouping, and hand dominance. Twenty-two healthy young adults performed a bimanual dial rotation task that required left and right hand coordination to track a moving target on a computer monitor. Two groups were compared, either with or without four days of practice with augmented visual feedback. Four directional patterns were tested such that both hands moved either rightward (clockwise, leftward (counterclockwise, inward or outward relative to each other. Seven frequency ratios (3∶1, 2∶1, 3∶2, 1∶1, 2∶3. 1∶2, 1∶3 between the left and right hand were introduced. As expected, isofrequency patterns (1∶1 were performed more successfully than multifrequency patterns (non 1∶1. In addition, performance was more accurate when participants were required to move faster with the dominant right hand (1∶3, 1∶2 and 2∶3 than with the non-dominant left hand (3∶1, 2∶1, 3∶2. Interestingly, performance deteriorated as the relative angular velocity between the two hands increased, regardless of whether the required frequency ratio was an integer or non-integer. This contrasted with previous finger tapping research where the integer ratios generally led to less error than the non-integer ratios. We suggest that this is due to the different movement topologies that are required of each paradigm. Overall, we found that this visuomotor task was useful for testing the interaction of multiple coordination constraints as well as the release from these constraints with practice in the presence of

  8. Comparison of Ordinary Kriging and Multiple Indicator Kriging ...

    Michael O. Mensah

    Multiple Indicator Kriging (MIK) is one of the popular non-linear methods that can handle skewed distribution such as that for gold ... historical deposits: Nkran, Adubia, Abore, and a ... information from the mine on the geology of the deposit.

  9. Testing and comparison of seventeen decontamination chemicals

    Demmer, R.L.

    1996-09-01

    This report details the testing and evaluation of seventeen decontamination chemicals. Tests were conducted with SIMCON (simulated contamination) coupons under controlled conditions to compare cleaning effectiveness, overall corrosion potential for plant equipment, interim waste generation and final waste generation

  10. Assessment of patients with multiple sclerosis according to tests of the Multiple Sclerosis Functional Composite

    Anelise Ineu Figueiredo

    Full Text Available Abstract Introduction: The Multiple Sclerosis Functional Composite (MSFC is a scale that evaluates the functional and cognitive aspects of patients with multiple sclerosis (MS. Objective: To compare the performance of individuals with the relapsing-remitting form of MS (RRMS with a group of healthy subjects using the MSFC. Methods: Twenty subjects were investigated in this study, consisting of 10 patients with clinical diagnosis of RRMS and 10 controls with similar gender and age to the group with the disease. The three tests that comprise the MSFC were used for the evaluation of gait, upper limb motor function and cognition (memory and processing speed. Student's t-test was used to assess data with normal distribution and data with skewed distribution were evaluated using the Mann-Whitney test. Results: The results showed that the patients with RRMS took longer to perform the locomotion test (6.91 ± 2.35 compared to the control group (5.16 ± 1.28. The MS group (22.06 ± 5.44 also showed greater difficulty in performing a task with the dominant upper limb compared to the healthy subjects (17.79 ± 2.96. No statistically significant difference was found between the groups in the performance of cognitive tasks (p = .65. Conclusion: The use of the MSFC tests proved valuable for measuring possible motor and cognitive impairments in patients with RRMS. Thus, it is suggested that this scale is adopted in clinical practice, improving therapies for the treatment of MS patients and thereby providing them a better quality of life.

  11. Comparison of testing methods for particulate filters

    Ullmann, W.; Przyborowski, S.

    1983-01-01

    Four testing methods for particulate filters were compared by using the test rigs of the National Board of Nuclear Safety and Radiation Protection: 1) Measurement of filter penetration P as a function of particle size d by using a polydisperse NaC1 test aerosol and a scintillation particle counter; 2) Modified sodium flame test for measurement of total filter penetration P for various polydisperse NaC1 test aerosols; 3) Measurement of total filter penetration P for a polydisperse NaC1 test aerosol labelled with short-lived radon daughter products; 4) Measurement of total filter penetration P for a special paraffin oil test aerosol (oil fog test used in FRG according DIN 24 184, test aerosol A). The investigations were carried out on sheets of glass fibre paper (five grades of paper). Detailed information about the four testing methods and the used particle size distributions is given. The different results of the various methods are the base for the discussion of the most important parameters which influence the filter penetration P. The course of the function P=f(d) shows the great influence of the particle size. As expected there was also found a great dependence both from the test aerosol as well as from the principle and the measuring range of the aerosol-measuring device. The differences between the results of the various test methods are greater the lower the penetration. The use of NaCl test aerosol with various particle size distributions gives great differences for the respective penetration values. On the basis of these results and the values given by Dorman conclusions are made about the investigation of particulate filters both for the determination of filter penetration P as well as for the leak test of installed filters

  12. Comparison of multiple support excitation solution techniques for piping systems

    Sterkel, H.P.; Leimbach, K.R.

    1980-01-01

    Design and analysis of nuclear power plant piping systems exposed to a variety of dynamic loads often require multiple support excitation analysis by modal or direct time integration methods. Both methods have recently been implemented in the computer program KWUROHR for static and dynamic analysis of piping systems, following the previous implementation of the multiple support excitation response spectrum method (see papers K 6/15 and K 6/15a of the SMiRT-4 Conference). The results of multiple support excitation response spectrum analyses can be examined by carrying out the equivalent time history analyses which do not distort the time phase relationship between the excitations at different support points. A frequent point of discussion is multiple versus single support excitation. A single support excitation analysis is computationally straightforward and tends to be on the conservative side, as the numerical results show. A multiple support excitation analysis, however, does not incur much more additional computer cost than the expenditure for an initial static solution involving three times the number, L, of excitation levels, i.e. 3L static load cases. The results are more realistic than those from a single support excitation analysis. A number of typical nuclear plant piping systems have been analyzed using single and multiple support excitation algorithms for: (1) the response spectrum method, (2) the modal time history method via the Wilson, Newmark and Goldberg integration operators and (3) the direct time history method via the Wilson integration operator. Characteristic results are presented to compare the computational quality of all three methods. (orig.)

  13. MultiSETTER: web server for multiple RNA structure comparison.

    Čech, Petr; Hoksza, David; Svozil, Daniel

    2015-08-12

    Understanding the architecture and function of RNA molecules requires methods for comparing and analyzing their tertiary and quaternary structures. While structural superposition of short RNAs is achievable in a reasonable time, large structures represent much bigger challenge. Therefore, we have developed a fast and accurate algorithm for RNA pairwise structure superposition called SETTER and implemented it in the SETTER web server. However, though biological relationships can be inferred by a pairwise structure alignment, key features preserved by evolution can be identified only from a multiple structure alignment. Thus, we extended the SETTER algorithm to the alignment of multiple RNA structures and developed the MultiSETTER algorithm. In this paper, we present the updated version of the SETTER web server that implements a user friendly interface to the MultiSETTER algorithm. The server accepts RNA structures either as the list of PDB IDs or as user-defined PDB files. After the superposition is computed, structures are visualized in 3D and several reports and statistics are generated. To the best of our knowledge, the MultiSETTER web server is the first publicly available tool for a multiple RNA structure alignment. The MultiSETTER server offers the visual inspection of an alignment in 3D space which may reveal structural and functional relationships not captured by other multiple alignment methods based either on a sequence or on secondary structure motifs.

  14. Multiple function benefit - cost comparison of conservation buffer placement strategies

    Z. Qiu; M.G. Dosskey

    2012-01-01

    Conservation buffers are considered to be effective practices for repairing impaired streams and restoring multiple ecosystem functions in degraded agricultural watersheds. Six different planning strategies for targeting their placement within watersheds were compared in terms of cost-effectiveness for environmental improvement in the 144 km² Neshanic River...

  15. Anthropometric comparison of Anthropometric Test Device (ATD ...

    Anthropometric test device (ATD) is surrogate used in automotive crash testing. Female ATDs used worldwide in the evaluation of vehicle safety performance was produced based on anthropometry of U.S. population. This work is aimed at assessing the difference between the anthropometric dimensions of Nigerian female ...

  16. Multiple comparisons in drug efficacy studies: scientific or marketing principles?

    Leo, Jonathan

    2004-01-01

    When researchers design an experiment to compare a given medication to another medication, a behavioral therapy, or a placebo, the experiment often involves numerous comparisons. For instance, there may be several different evaluation methods, raters, and time points. Although scientifically justified, such comparisons can be abused in the interests of drug marketing. This article provides two recent examples of such questionable practices. The first involves the case of the arthritis drug celecoxib (Celebrex), where the study lasted 12 months but the authors only presented 6 months of data. The second case involves the NIMH Multimodal Treatment Study (MTA) study evaluating the efficacy of stimulant medication for attention-deficit hyperactivity disorder where ratings made by several groups are reported in contradictory fashion. The MTA authors have not clarified the confusion, at least in print, suggesting that the actual findings of the study may have played little role in the authors' reported conclusions.

  17. Comparison of Automated Graphical User Interface Testing Tools

    Gaber, Domen

    2018-01-01

    The thesis presents the analysis of modern tools for automated testing of various web based user interfaces. The purpose of the work is to compare specific test automation solutions and point out the most suitable test automation tool amongst them. One of the main goals of test automation is to gain faster execution when compared to manual testing and overall cost deduction. There are multiple test automation solutions available on the market, which differ in complexity of use, type of o...

  18. Tests for homogeneity for multiple 2 x 2 contingency tables

    Carr, D.B.

    1986-01-01

    Frequently data are described by 2 x 2 contingency tables. For example, each 2 x 2 table arises from two dichotomous classifications such as control/treated and respond/did not respond. Multiple 2 x 2 tables result from stratifying the observational units on the basis of other characteristics. For example, stratifying by sex produces separate 2 x 2 tables for males and females. From each table a measure of difference between the response rates for the control and the treated groups is computed. The researcher usually wants to know if the response-rate difference is zero for each table. If the tables are homogeneous, the researcher can generalize from a statement concerning an average to a statement concerning each table. If tables are not homogeneous, homogeneous subsets of the tables should be described separately. This paper presents tests for homogeneity and illustrates their use. 11 refs., 6 tabs

  19. Tests and comparisons of gravity models.

    Marsh, J. G.; Douglas, B. C.

    1971-01-01

    Optical observations of the GEOS satellites were used to obtain orbital solutions with different sets of geopotential coefficients. The solutions were compared before and after modification to high order terms (necessary because of resonance) and were then analyzed by comparing subsequent observations with predicted trajectories. The most important source of error in orbit determination and prediction for the GEOS satellites is the effect of resonance found in most published sets of geopotential coefficients. Modifications to the sets yield greatly improved orbits in most cases. The results of these comparisons suggest that with the best optical tracking systems and gravity models, satellite position error due to gravity model uncertainty can reach 50-100 m during a heavily observed 5-6 day orbital arc. If resonant coefficients are estimated, the uncertainty is reduced considerably.

  20. Comparison of heat-testing methodology.

    Bierma, Mark M; McClanahan, Scott; Baisden, Michael K; Bowles, Walter R

    2012-08-01

    Patients with irreversible pulpitis occasionally present with a chief complaint of sensitivity to heat. To appropriately diagnose the offending tooth, a variety of techniques have been developed to reproduce this chief complaint. Such techniques cause temperature increases that are potentially damaging to the pulp. Newer electronic instruments control the temperature of a heat-testing tip that is placed directly against a tooth. The aim of this study was to determine which method produced the most consistent and safe temperature increase within the pulp. This consistency facilitates the clinician's ability to differentiate between a normal pulp and irreversible pulpitis. Four operators applied the following methods to each of 4 extracted maxillary premolars (for a total of 16 trials per method): heated gutta-percha, heated ball burnisher, hot water, and a System B unit or Elements unit with a heat-testing tip. Each test was performed for 60 seconds, and the temperatures were recorded via a thermocouple in the pulp chamber. Analysis of the data was performed by using the intraclass correlation coefficient. The least consistent warming was found with hot water. The heat-testing tip also demonstrated greater consistency between operators compared with the other methods. Hot water and the heated ball burnisher caused temperature increases high enough to damage pulp tissue. The Elements unit with a heat-testing tip provides the most consistent warming of the dental pulp. Copyright © 2012 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  1. Testing multiple statistical hypotheses resulted in spurious associations: a study of astrological signs and health.

    Austin, Peter C; Mamdani, Muhammad M; Juurlink, David N; Hux, Janet E

    2006-09-01

    To illustrate how multiple hypotheses testing can produce associations with no clinical plausibility. We conducted a study of all 10,674,945 residents of Ontario aged between 18 and 100 years in 2000. Residents were randomly assigned to equally sized derivation and validation cohorts and classified according to their astrological sign. Using the derivation cohort, we searched through 223 of the most common diagnoses for hospitalization until we identified two for which subjects born under one astrological sign had a significantly higher probability of hospitalization compared to subjects born under the remaining signs combined (P<0.05). We tested these 24 associations in the independent validation cohort. Residents born under Leo had a higher probability of gastrointestinal hemorrhage (P=0.0447), while Sagittarians had a higher probability of humerus fracture (P=0.0123) compared to all other signs combined. After adjusting the significance level to account for multiple comparisons, none of the identified associations remained significant in either the derivation or validation cohort. Our analyses illustrate how the testing of multiple, non-prespecified hypotheses increases the likelihood of detecting implausible associations. Our findings have important implications for the analysis and interpretation of clinical studies.

  2. Comparison of performance test for protective aprons

    Fukutomi, Yukimi; Yoshimoto, Masahiro; Kawakami, Toshiaki

    1989-01-01

    Each one radioprotective apron (lead equivalent, 0.35 mmPb) was commercially available in November 1988 from 7 domestic and 3 foreign companies. According to the JIS standards 4803, these aprons were evaluated for the following items: 1) display of aprons, including packing and the structure; 2) non-breaking test, including appearance, size, lead equivalent, and uniformity; 3) breaking test, including lead equivalent, uniformity, stregth, and structure; 4) feeling of wearing an apron. An overall evaluation revealed that only two aprons were in accordance with the JIS standard. Careful wearing of the protective apron is stressed. (N.K.)

  3. Assessment Guide for Educators: A Content Comparison--2002 Series Test and the Current GED® Test

    GED Testing Service, 2017

    2017-01-01

    This report provides a content comparison for the 2002 Series GED® test and the current GED® for the following test topic areas: (1) Mathematical Reasoning; (2) Reasoning through Language Arts; (3) Science; and (4) Social Studies.

  4. Comparison of the Clock Test and a questionnaire-based test for ...

    Comparison of the Clock Test and a questionnaire-based test for screening for cognitive impairment in Nigerians. D J VanderJagt, S Ganga, M O Obadofin, P Stanley, M Zimmerman, B J Skipper, R H Glew ...

  5. Finite Element Analysis and Test Results Comparison for the Hybrid Wing Body Center Section Test Article

    Przekop, Adam; Jegley, Dawn C.; Rouse, Marshall; Lovejoy, Andrew E.

    2016-01-01

    This report documents the comparison of test measurements and predictive finite element analysis results for a hybrid wing body center section test article. The testing and analysis efforts were part of the Airframe Technology subproject within the NASA Environmentally Responsible Aviation project. Test results include full field displacement measurements obtained from digital image correlation systems and discrete strain measurements obtained using both unidirectional and rosette resistive gauges. Most significant results are presented for the critical five load cases exercised during the test. Final test to failure after inflicting severe damage to the test article is also documented. Overall, good comparison between predicted and actual behavior of the test article is found.

  6. Depression and pain: testing of serial multiple mediators.

    Wongpakaran, Tinakon; Wongpakaran, Nahathai; Tanchakvaranont, Sitthinant; Bookkamana, Putipong; Pinyopornpanish, Manee; Wannarit, Kamonporn; Satthapisit, Sirina; Nakawiro, Daochompu; Hiranyatheb, Thanita; Thongpibul, Kulvadee

    2016-01-01

    Despite the fact that pain is related to depression, few studies have been conducted to investigate the variables that mediate between the two conditions. In this study, the authors explored the following mediators: cognitive function, self-sacrificing interpersonal problems, and perception of stress, and the effects they had on pain symptoms among patients with depressive disorders. An analysis was performed on the data of 346 participants with unipolar depressive disorders. The 17-item Hamilton Depression Rating Scale, Mini-Mental State Examination, the pain subscale of the health-related quality of life (SF-36), the self-sacrificing subscale of the Inventory of Interpersonal Problems, and the Perceived Stress Scale were used. Parallel multiple mediator and serial multiple mediator models were used. An alternative model regarding the effect of self-sacrificing on pain was also proposed. Perceived stress, self-sacrificing interpersonal style, and cognitive function were found to significantly mediate the relationship between depression and pain, while controlling for demographic variables. The total effect of depression on pain was significant. This model, with an additional three mediators, accounted for 15% of the explained variance in pain compared to 9% without mediators. For the alternative model, after controlling for the mediators, a nonsignificant total direct effect level of self-sacrificing was found, suggesting that the effect of self-sacrificing on pain was based only on an indirect effect and that perceived stress was found to be the strongest mediator. Serial mediation may help us to see how depression and pain are linked and what the fundamental mediators are in the chain. No significant, indirect effect of self-sacrificing on pain was observed, if perceived stress was not part of the depression and/or cognitive function mediational chain. The results shown here have implications for future research, both in terms of testing the model and in

  7. Comparison of sine dwell and broadband methods for modal testing

    Chen, Jay-Chung

    1989-01-01

    The objectives of modal tests for large complex spacecraft structural systems are outlined. The comparison criteria for the modal test methods, namely, the broadband excitation and the sine dwell methods, are established. Using the Galileo spacecraft modal test and the Centaur G Prime upper stage vehicle modal test as examples, the relative advantage or disadvantage of each method is examined. The usefulness or shortcomings of the methods are given from a practical engineering viewpoint.

  8. Comparisons of Particulate Size Distributions from Multiple Combustion Strategies

    Zhang, Yizhou

    In this study, a comparison of particle size distribution (PSD) measurements from eight different combustion strategies was conducted at four different load-speed points. The PSDs were measured using a scanning mobility particle sizer (SMPS) together with a condensation particle counter (CPC). To study the influence of volatile particles, PSD measurements were performed with and without a volatile particle remover (thermodenuder, TD) at both low and high dilution ratios. The common engine platform utilized in the experiment helps to eliminate the influence of background particulate and ensures similarity in dilution conditions. The results show a large number of volatile particles were present under LDR sample conditions for most of the operating conditions. The use of a TD, especially when coupled with HDR, was demonstrated to be effective at removing volatile particles and provided consistent measurements across all combustion strategies. The PSD comparison showed that gasoline premixed combustion strategies such as HCCI and GCI generally have low PSD magnitudes for particle sizes greater than the Particle Measurement Programme (PMP) cutoff diameter (23 nm), and the PSDs were highly nuclei-mode particle dominated. The strategies using diesel as the only fuel (DLTC and CDC) generally showed the highest particle number emissions for particles larger than 23 nm and had accumulation-mode particle dominated PSDs. A consistent correlation between the increase of the direct-injection of diesel fuel and a higher fraction of accumulation-mode particles was observed over all combustion strategies. A DI fuel substitution study and injector nozzle geometry study were conducted to better understand the correlation between PSD shape and DI fueling. It was found that DI fuel properties has a clear impact on PSD behavior for CDC and NG DPI. Fuel with lower density and lower sooting tendency led to a nuclei-mode particle dominated PSD shape. For NG RCCI, accumulation

  9. INTER LABORATORY COMBAT HELMET BLUNT IMPACT TEST METHOD COMPARISON

    2018-03-26

    data by Instrumentation for Impact  Test , SAE standard J211‐1 [4]. Although the entire curve is collected, the interest of this  project  team  solely...HELMET BLUNT IMPACT TEST METHOD COMPARISON by Tony J. Kayhart Charles A. Hewitt and Jonathan Cyganik March 2018 Final...INTER-LABORATORY COMBAT HELMET BLUNT IMPACT TEST METHOD COMPARISON 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR

  10. BIOMOVS test scenario model comparison using BIOPATH

    Grogan, H.A.; Van Dorp, F.

    1986-07-01

    This report presents the results of the irrigation test scenario, presented in the BIOMOVS intercomparison study, calculated by the computer code BIOPATH. This scenario defines a constant release of Tc-99 and Np-237 into groundwater that is used for irrigation. The system of compartments used to model the biosphere is based upon an area in northern Switzerland and is essentially the same as that used in Projekt Gewaehr to assess the radiological impact of a high level waste repository. Two separate irrigation methods are considered, namely ditch and overhead irrigation. Their influence on the resultant activities calculated in the groundwater, soil and different foodproducts, as a function of time, is evaluated. The sensitivity of the model to parameter variations is analysed which allows a deeper understanding of the model chain. These results are assessed subjectively in a first effort to realistically quantify the uncertainty associated with each calculated activity. (author)

  11. Reproducibility of R-fMRI metrics on the impact of different strategies for multiple comparison correction and sample sizes.

    Chen, Xiao; Lu, Bin; Yan, Chao-Gan

    2018-01-01

    Concerns regarding reproducibility of resting-state functional magnetic resonance imaging (R-fMRI) findings have been raised. Little is known about how to operationally define R-fMRI reproducibility and to what extent it is affected by multiple comparison correction strategies and sample size. We comprehensively assessed two aspects of reproducibility, test-retest reliability and replicability, on widely used R-fMRI metrics in both between-subject contrasts of sex differences and within-subject comparisons of eyes-open and eyes-closed (EOEC) conditions. We noted permutation test with Threshold-Free Cluster Enhancement (TFCE), a strict multiple comparison correction strategy, reached the best balance between family-wise error rate (under 5%) and test-retest reliability/replicability (e.g., 0.68 for test-retest reliability and 0.25 for replicability of amplitude of low-frequency fluctuations (ALFF) for between-subject sex differences, 0.49 for replicability of ALFF for within-subject EOEC differences). Although R-fMRI indices attained moderate reliabilities, they replicated poorly in distinct datasets (replicability < 0.3 for between-subject sex differences, < 0.5 for within-subject EOEC differences). By randomly drawing different sample sizes from a single site, we found reliability, sensitivity and positive predictive value (PPV) rose as sample size increased. Small sample sizes (e.g., < 80 [40 per group]) not only minimized power (sensitivity < 2%), but also decreased the likelihood that significant results reflect "true" effects (PPV < 0.26) in sex differences. Our findings have implications for how to select multiple comparison correction strategies and highlight the importance of sufficiently large sample sizes in R-fMRI studies to enhance reproducibility. Hum Brain Mapp 39:300-318, 2018. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  12. Comparison of DVH data from multiple radiotherapy treatment planning systems

    Ebert, M A; Kearvell, R; Hooton, B; Spry, N A; Bydder, S A; Joseph, D J; Haworth, A; Hug, B

    2010-01-01

    This study examined the variation of dose-volume histogram (DVH) data sourced from multiple radiotherapy treatment planning systems (TPSs). Treatment plan exports were obtained from 33 Australian and New Zealand centres during a dosimetry study. Plan information, including DVH data, was exported from the TPS at each centre and reviewed in a digital review system (SWAN). The review system was then used to produce an independent calculation of DVH information for each delineated structure. The relationships between DVHs extracted from each TPS and independently calculated were examined, particularly in terms of the influence of CT scan slice and pixel widths, the resolution of dose calculation grids and the TPS manufacturer. Calculation of total volume and DVH data was consistent between SWAN and each TPS, with the small discrepancies found tending to increase with decreasing structure size. This was significantly influenced by the TPS model used to derive the data. For target structures covered with relatively uniform dose distributions, there was a significant difference between the minimum dose in each TPS-exported DVH and that calculated independently. (note)

  13. Multiple Criteria and Multiple Periods Performance Analysis: The Comparison of North African Railways

    Sabri, Karim; Colson, Gérard E.; Mbangala, Augustin M.

    2008-10-01

    Multi-period differences of technical and financial performances are analysed by comparing five North African railways over the period (1990-2004). A first approach is based on the Malmquist DEA TFP index for measuring the total factors productivity change, decomposed into technical efficiency change and technological changes. A multiple criteria analysis is also performed using the PROMETHEE II method and the software ARGOS. These methods provide complementary detailed information, especially by discriminating the technological and management progresses by Malmquist and the two dimensions of performance by Promethee: that are the service to the community and the enterprises performances, often in conflict.

  14. Bayesian models based on test statistics for multiple hypothesis testing problems.

    Ji, Yuan; Lu, Yiling; Mills, Gordon B

    2008-04-01

    We propose a Bayesian method for the problem of multiple hypothesis testing that is routinely encountered in bioinformatics research, such as the differential gene expression analysis. Our algorithm is based on modeling the distributions of test statistics under both null and alternative hypotheses. We substantially reduce the complexity of the process of defining posterior model probabilities by modeling the test statistics directly instead of modeling the full data. Computationally, we apply a Bayesian FDR approach to control the number of rejections of null hypotheses. To check if our model assumptions for the test statistics are valid for various bioinformatics experiments, we also propose a simple graphical model-assessment tool. Using extensive simulations, we demonstrate the performance of our models and the utility of the model-assessment tool. In the end, we apply the proposed methodology to an siRNA screening and a gene expression experiment.

  15. Depression and pain: testing of serial multiple mediators

    Wongpakaran T

    2016-07-01

    function were found to significantly mediate the relationship between depression and pain, while controlling for demographic variables. The total effect of depression on pain was significant. This model, with an additional three mediators, accounted for 15% of the explained variance in pain compared to 9% without mediators. For the alternative model, after controlling for the mediators, a nonsignificant total direct effect level of self-sacrificing was found, suggesting that the effect of self-sacrificing on pain was based only on an indirect effect and that perceived stress was found to be the strongest mediator.Conclusion: Serial mediation may help us to see how depression and pain are linked and what the fundamental mediators are in the chain. No significant, indirect effect of self-sacrificing on pain was observed, if perceived stress was not part of the depression and/or cognitive function mediational chain. The results shown here have implications for future research, both in terms of testing the model and in clinical application. Keywords: depressive disorder, mediator, serial mediation, multiple mediation

  16. Steady reconstruction process - development, testing and comparison in ultrasonic testing

    Langenberg, K.J.; Schmitz, V.

    1986-01-01

    The fault parameters can be extracted from a few data of high quality in steady test procedures. The boundary conditions for the successful use of such a process were researched and found, so that by using theoretical models for the elasto-dynamic interaction of fault and ultrasonics, a concentration of wavefronts instead of resonances and a wide band careful collection of data makes a physical interpretation in the form of specific geometry torques possible. Models of the interaction of ultrasonics and faults for two fault geometries (cracks and pores) were developed which permit the calculation of A scans of any bandwidth and with any angle of scatter for the direct and mode converted parts of the elastic ultrasonic scatter wave. The curved pressure and shear waves including the mode converted bending fields over an angular range of 360deg were experimentally recorded. Their agreement including the additional wavefronts caused by the close field of the crack bending field is close. Classification of torques is done on two examples (crack, cylinder) for evaluation purposes. It was found that a classification was possible according to the sign of the a 1 polynomial coefficient. (orig./HP) [de

  17. An Application of Graphical Approach to Construct Multiple Testing Procedure in a Hypothetical Phase III Design

    Naitee eTing

    2014-01-01

    Full Text Available Many multiple testing procedures (MTP have been developed in recent years. Among these new procedures, the graphical approach is flexible and easy to communicate with non-statisticians. A hypothetical Phase III clinical trial design is introduced in this manuscript to demonstrate how graphical approach can be applied in clinical product development. In this design, an active comparator is used. It is thought that this test drug under development could potentially be superior to this comparator. For comparison of efficacy, the primary endpoint is well established and widely accepted by regulatory agencies. However, an important secondary endpoint based on Phase II findings looks very promising. The target dose may have a good opportunity to deliver superiority to the comparator. Furthermore, a lower dose is included in case the target dose may demonstrate potential safety concerns. This Phase III study is designed as a non-inferiority trial with two doses, and two endpoints. This manuscript will illustrate how graphical approach is applied to this design in handling multiple testing issues.

  18. A multiple objective test assembly approach for exposure control problems in Computerized Adaptive Testing

    Theo J.H.M. Eggen

    2010-01-01

    Full Text Available Overexposure and underexposure of items in the bank are serious problems in operational computerized adaptive testing (CAT systems. These exposure problems might result in item compromise, or point at a waste of investments. The exposure control problem can be viewed as a test assembly problem with multiple objectives. Information in the test has to be maximized, item compromise has to be minimized, and pool usage has to be optimized. In this paper, a multiple objectives method is developed to deal with both types of exposure problems. In this method, exposure control parameters based on observed exposure rates are implemented as weights for the information in the item selection procedure. The method does not need time consuming simulation studies, and it can be implemented conditional on ability level. The method is compared with Sympson Hetter method for exposure control, with the Progressive method and with alphastratified testing. The results show that the method is successful in dealing with both kinds of exposure problems.

  19. Multiple Monte Carlo Testing with Applications in Spatial Point Processes

    Mrkvička, Tomáš; Myllymäki, Mari; Hahn, Ute

    with a function as the test statistic, 3) several Monte Carlo tests with functions as test statistics. The rank test has correct (global) type I error in each case and it is accompanied with a p-value and with a graphical interpretation which shows which subtest or which distances of the used test function......(s) lead to the rejection at the prescribed significance level of the test. Examples of null hypothesis from point process and random set statistics are used to demonstrate the strength of the rank envelope test. The examples include goodness-of-fit test with several test functions, goodness-of-fit test...

  20. Comparison of the sensitivities of the Buehler test and the guinea pig maximization test for predictive testing of contact allergy

    Frankild, S; Vølund, A; Wahlberg, J E

    2001-01-01

    International test guidelines, such as the Organisation for Economic Cooperation and Development (OECD) guideline #406, recommend 2 guinea pig methods for testing of the contact allergenic potential of chemicals: the Guinea Pig Maximization Test (GPMT) and the Buehler test. Previous comparisons...

  1. The Efficiency of Quantum Identity Testing of Multiple States

    Kada, Masaru; Nishimura, Harumichi; Yamakami, Tomoyuki

    2008-01-01

    We examine two quantum operations, the Permutation Test and the Circle Test, which test the identity of n quantum states. These operations naturally extend the well-studied Swap Test on two quantum states. We first show the optimality of the Permutation Test for any input size n as well as the optimality of the Circle Test for three input states. In particular, when n=3, we present a semi-classical protocol, incorporated with the Swap Test, which approximates the Circle Test efficiently. Furt...

  2. Default mode network links to visual hallucinations: A comparison between Parkinson's disease and multiple system atrophy.

    Franciotti, Raffaella; Delli Pizzi, Stefano; Perfetti, Bernardo; Tartaro, Armando; Bonanni, Laura; Thomas, Astrid; Weis, Luca; Biundo, Roberta; Antonini, Angelo; Onofrj, Marco

    2015-08-01

    Studying default mode network activity or connectivity in different parkinsonisms, with or without visual hallucinations, could highlight its roles in clinical phenotypes' expression. Multiple system atrophy is the archetype of parkinsonism without visual hallucinations, variably appearing instead in Parkinson's disease (PD). We aimed to evaluate default mode network functions in multiple system atrophy in comparison with PD. Functional magnetic resonance imaging evaluated default mode network activity and connectivity in 15 multiple system atrophy patients, 15 healthy controls, 15 early PD patients matched for disease duration, 30 severe PD patients (15 with and 15 without visual hallucinations), matched with multiple system atrophy for disease severity. Cortical thickness and neuropsychological evaluations were also performed. Multiple system atrophy had reduced default mode network activity compared with controls and PD with hallucinations, and no differences with PD (early or severe) without hallucinations. In PD with visual hallucinations, activity and connectivity was preserved compared with controls and higher than in other groups. In early PD, connectivity was lower than in controls but higher than in multiple system atrophy and severe PD without hallucinations. Cortical thickness was reduced in severe PD, with and without hallucinations, and correlated only with disease duration. Higher anxiety scores were found in patients without hallucinations. Default mode network activity and connectivity was higher in PD with visual hallucinations and reduced in multiple system atrophy and PD without visual hallucinations. Cortical thickness comparisons suggest that functional, rather than structural, changes underlie the activity and connectivity differences. © 2015 International Parkinson and Movement Disorder Society.

  3. Comparison of Intelligibility Measures for Adults with Parkinson's Disease, Adults with Multiple Sclerosis, and Healthy Controls

    Stipancic, Kaila L.; Tjaden, Kris; Wilding, Gregory

    2016-01-01

    Purpose: This study obtained judgments of sentence intelligibility using orthographic transcription for comparison with previously reported intelligibility judgments obtained using a visual analog scale (VAS) for individuals with Parkinson's disease and multiple sclerosis and healthy controls (K. Tjaden, J. E. Sussman, & G. E. Wilding, 2014).…

  4. Test of understanding of vectors: A reliable multiple-choice vector concept test

    Barniol, Pablo; Zavala, Genaro

    2014-06-01

    In this article we discuss the findings of our research on students' understanding of vector concepts in problems without physical context. First, we develop a complete taxonomy of the most frequent errors made by university students when learning vector concepts. This study is based on the results of several test administrations of open-ended problems in which a total of 2067 students participated. Using this taxonomy, we then designed a 20-item multiple-choice test [Test of understanding of vectors (TUV)] and administered it in English to 423 students who were completing the required sequence of introductory physics courses at a large private Mexican university. We evaluated the test's content validity, reliability, and discriminatory power. The results indicate that the TUV is a reliable assessment tool. We also conducted a detailed analysis of the students' understanding of the vector concepts evaluated in the test. The TUV is included in the Supplemental Material as a resource for other researchers studying vector learning, as well as instructors teaching the material.

  5. Should methods of correction for multiple comparisons be applied in pharmacovigilance?

    Lorenza Scotti

    2015-12-01

    Full Text Available Purpose. In pharmacovigilance, spontaneous reporting databases are devoted to the early detection of adverse event ‘signals’ of marketed drugs. A common limitation of these systems is the wide number of concurrently investigated associations, implying a high probability of generating positive signals simply by chance. However it is not clear if the application of methods aimed to adjust for the multiple testing problems are needed when at least some of the drug-outcome relationship under study are known. To this aim we applied a robust estimation method for the FDR (rFDR particularly suitable in the pharmacovigilance context. Methods. We exploited the data available for the SAFEGUARD project to apply the rFDR estimation methods to detect potential false positive signals of adverse reactions attributable to the use of non-insulin blood glucose lowering drugs. Specifically, the number of signals generated from the conventional disproportionality measures and after the application of the rFDR adjustment method was compared. Results. Among the 311 evaluable pairs (i.e., drug-event pairs with at least one adverse event report, 106 (34% signals were considered as significant from the conventional analysis. Among them 1 resulted in false positive signals according to rFDR method. Conclusions. The results of this study seem to suggest that when a restricted number of drug-outcome pairs is considered and warnings about some of them are known, multiple comparisons methods for recognizing false positive signals are not so useful as suggested by theoretical considerations.

  6. Planned Hypothesis Tests Are Not Necessarily Exempt from Multiplicity Adjustment

    Frane, Andrew V.

    2015-01-01

    Scientific research often involves testing more than one hypothesis at a time, which can inflate the probability that a Type I error (false discovery) will occur. To prevent this Type I error inflation, adjustments can be made to the testing procedure that compensate for the number of tests. Yet many researchers believe that such adjustments are…

  7. Multiple Intelligences Profiles of Children with Attention Deficit and Hyperactivity Disorder in Comparison with Nonattention Deficit and Hyperactivity Disorder.

    Najafi, Mostafa; Akouchekian, Shahla; Ghaderi, Alireza; Mahaki, Behzad; Rezaei, Mariam

    2017-01-01

    Attention deficit and hyperactivity disorder (ADHD) is a common psychological problem during childhood. This study aimed to evaluate multiple intelligences profiles of children with ADHD in comparison with non-ADHD. This cross-sectional descriptive analytical study was done on 50 children of 6-13 years old in two groups of with and without ADHD. Children with ADHD were referred to Clinics of Child and Adolescent Psychiatry, Isfahan University of Medical Sciences, in 2014. Samples were selected based on clinical interview (based on Diagnostic and Statistical Manual of Mental Disorders IV and parent-teacher strengths and difficulties questionnaire), which was done by psychiatrist and psychologist. Raven intelligence quotient (IQ) test was used, and the findings were compared to the results of multiple intelligences test. Data analysis was done using a multivariate analysis of covariance using SPSS20 software. Comparing the profiles of multiple intelligence among two groups, there are more kinds of multiple intelligences in control group than ADHD group, a difference which has been more significant in logical, interpersonal, and intrapersonal intelligence ( P multiple intelligences in two groups ( P > 0.05). The IQ average score in the control group and ADHD group was 102.42 ± 16.26 and 96.72 ± 16.06, respectively, that reveals the negative effect of ADHD on IQ average value. There was an insignificance relationship between linguistic and naturalist intelligence ( P > 0.05). However, in other kinds of multiple intelligences, direct and significant relationships were observed ( P < 0.05). Since the levels of IQ (Raven test) and MI in control group were more significant than ADHD group, ADHD is likely to be associated with logical-mathematical, interpersonal, and intrapersonal profiles.

  8. Competition in Multiple Characteristics: An Empirical Test of Location Equilibrium.

    Elizalde, J. (Javier)

    2010-01-01

    With products differentiated in multiple dimensions, the location equilibrium for a duopolistic market exhibits aximum differentiation in one dimension and minimum differentiation in all the other dimensions. This paper analyses whether this equilibrium arises using real data for the Spanish movie theatre exhibition market where the firms (cinemas) are differentiated along two dimensions (their geographical location and the set of movies exhibited). Data not only shows a trade-off such that c...

  9. Comparison of computer code calculations with FEBA test data

    Zhu, Y.M.

    1988-06-01

    The FEBA forced feed reflood experiments included base line tests with unblocked geometry. The experiments consisted of separate effect tests on a full-length 5x5 rod bundle. Experimental cladding temperatures and heat transfer coefficients of FEBA test No. 216 are compared with the analytical data postcalculated utilizing the SSYST-3 computer code. The comparison indicates a satisfactory matching of the peak cladding temperatures, quench times and heat transfer coefficients for nearly all axial positions. This agreement was made possible by the use of an artificially adjusted value of the empirical code input parameter in the heat transfer for the dispersed flow regime. A limited comparison of test data and calculations using the RELAP4/MOD6 transient analysis code are also included. In this case the input data for the water entrainment fraction and the liquid weighting factor in the heat transfer for the dispersed flow regime were adjusted to match the experimental data. On the other hand, no fitting of the input parameters was made for the COBRA-TF calculations which are included in the data comparison. (orig.) [de

  10. Comparison of Critical Flow Models' Evaluations for SBLOCA Tests

    Kim, Yeon Sik; Park, Hyun Sik; Cho, Seok

    2016-01-01

    A comparison of critical flow models between the Trapp-Ransom and Henry-Fauske models for all SBLOCA (small break loss of coolant accident) scenarios of the ATLAS (Advanced thermal-hydraulic test loop for accident simulation) facility was performed using the MARS-KS code. For the comparison of the two critical models, the accumulated break mass was selected as the main parameter for the comparison between the analyses and tests. Four cases showed the same respective discharge coefficients between the two critical models, e.g., 6' CL (cold leg) break and 25%, 50%, and 100% DVI (direct vessel injection) breaks. In the case of the 4' CL break, no reasonable results were obtained with any possible Cd values. In addition, typical system behaviors, e.g., PZR (pressurizer) pressure and collapsed core water level, were also compared between the two critical models. Four cases showed the same respective discharge coefficients between the two critical models, e.g., 6' CL break and 25%, 50%, and 100% DVI breaks. In the case of the 4' CL break, no reasonable results were obtained with any possible Cd values. In addition, typical system behaviors, e.g., PZR pressure and collapsed core water level, were also compared between the two critical models. From the comparison between the two critical models for the CL breaks, the Trapp-Ransom model predicted quite well with respect to the other model for the smallest and larger breaks, e.g., 2', 6', and 8.5' CL breaks. In addition, from the comparison between the two critical models for the DVI breaks, the Trapp-Ransom model predicted quite well with respect to the other model for the smallest and larger breaks, e.g., 5%, 50%, and 100% DVI breaks. In the case of the 50% and 100% breaks, the two critical models predicted the test data quite well.

  11. Statistical tests for equal predictive ability across multiple forecasting methods

    Borup, Daniel; Thyrsgaard, Martin

    We develop a multivariate generalization of the Giacomini-White tests for equal conditional predictive ability. The tests are applicable to a mixture of nested and non-nested models, incorporate estimation uncertainty explicitly, and allow for misspecification of the forecasting model as well as ...

  12. Comparison of Parenting Style in Single Child and Multiple Children Families

    Masoumeh Alidosti

    2016-06-01

    Full Text Available Background and Purpose: Family is the first and the most important structure in human civilization in which social lifestyles, mutual understanding, and compatibility is learned. Studies have shown that parenting style, is one the most important and fundamental factors in personality development. The purpose of this study was comparison of parenting style in single child and multiple children families. Materials and Methods: This study, in total, 152 mothers from Andimeshk city, Iran, were selected by random sampling. Data were collected from a health-care center was chosen randomly, mothers who had 5-7 years old children were enrolled in this study. The data collecting tool was the questionnaire which investigates permissive, authoritative, and authoritarian parenting styles in parents. After data entry in SPSS software, the collected data were analyzed by ANOVA, independent t-test, and Pearson correlation test. Results: The mean age of the participants was 32.71 ± 5.39 years old participated in this study. 69 mothers (45.4% had one child, 53 (34.9% had 2 children, and 30 mothers (19.7% had 3 and more children. The mean score of permissive parenting style was 19.97 ± 5.13 in single child families; the mean score of authoritative (19.56 ± 4.70 and authoritarian parenting style (34.50 ± 2.81 that difference was significantly (P < 0.050. Conclusion: According to the results of this study, it seems that having more children would make parents more logical and paves the way for upbringing children. Therefore, it is recommended to plan some educational programs about this issue for parents.

  13. Comparison of Shock Response Spectrum for Different Gun Tests

    J.A. Cordes

    2013-01-01

    Full Text Available The Soft Catch Gun at Picatinny Arsenal is regularly used for component testing. Most shots contain accelerometers which record accelerations as a function of time. Statistics of accelerometer data indicate that the muzzle exit accelerations are, on average, higher than tactical firings. For that reason, Soft Catch Gun tests with unusually high accelerations may not be scored for Lot Acceptance Tests (LAT by some customers. The 95/50 Normal Tolerance Limit (NTL is proposed as a means of determining which test results should be scored. This paper presents comparisons of Shock Response Spectra (SRS used for the 95/50 scoring criteria. The paper also provides a Discussion Section outlining some concerns with scoring LAT results based on test results outside of the proposed 95/50 criteria.

  14. History and sensitivity comparison of the Spirodela polyrhiza microbiotest and Lemna toxicity tests

    Baudo R.

    2015-01-01

    Full Text Available The history of toxicity tests with duckweeds shows that these assays with free-floating aquatic angiosperms are gaining increasing attention in ecotoxicological research and applications. Standard tests have been published by national and international organizations, mainly with the test species Lemna minor and Lemna gibba. Besides the former two test species the great duckweed Spirodela polyrhiza is to date also regularly used in duckweed testing. Under unfavorable environmental conditions, the latter species produces dormant stages (turions and this has triggered the attention of two research groups from Belgium and Greece to jointly develop a “stock culture independent” microbiotest with S. polyrhiza. A 72 h new test has been worked out which besides its independence of stock culturing and maintenance of live stocks is very simple and practical to perform, and much less demanding in space and time than the conventional duckweed tests. Extensive International Interlaboratory Comparisons on the S. polyrhiza microbiotest showed its robustness and reliability and triggered the decision to propose this new assay to the ISO for endorsement and publication as a standard toxicity test for duckweeds. Sensitivity comparison of the 72 h S. polyrhiza microbiotest with the 7d L. minor assay for 22 compounds belonging to different groups of chemicals revealed that based on growth as the effect criterion both duckweed assays have a similar sensitivity. Taking into account its multiple advantages and assets, the S. polyrhiza microbiotest is a reliable and attractive alternative to the conventional duckweed tests.

  15. Testing subleading multiple soft graviton theorem for CHY prescription

    Chakrabarti, Subhroneel; Kashyap, Sitender Pratap; Sahoo, Biswajit; Sen, Ashoke; Verma, Mritunjay

    2018-01-01

    In arXiv:1707.06803 we derived the subleading multiple soft graviton theorem in a generic quantum theory of gravity for arbitrary number of soft external gravitons and arbitrary number of finite energy external states carrying arbitrary mass and spin. In this paper we verify this explicitly using the CHY formula for tree level scattering amplitudes of arbitrary number of gravitons in Einstein gravity. We pay special care to fix the signs of the amplitudes and resolve an apparent discrepancy between our general results in arXiv:1707.06803 and previous results on soft graviton theorem from CHY formula.

  16. Cascade Distillation Subsystem Development: Progress Toward a Distillation Comparison Test

    Callahan, M. R.; Lubman, A.; Pickering, Karen D.

    2009-01-01

    Recovery of potable water from wastewater is essential for the success of long-duration manned missions to the Moon and Mars. Honeywell International and a team from NASA Johnson Space Center (JSC) are developing a wastewater processing subsystem that is based on centrifugal vacuum distillation. The wastewater processor, referred to as the Cascade Distillation Subsystem (CDS), utilizes an innovative and efficient multistage thermodynamic process to produce purified water. The rotary centrifugal design of the system also provides gas/liquid phase separation and liquid transport under microgravity conditions. A five-stage subsystem unit has been designed, built, delivered and integrated into the NASA JSC Advanced Water Recovery Systems Development Facility for performance testing. A major test objective of the project is to demonstrate the advancement of the CDS technology from the breadboard level to a subsystem level unit. An initial round of CDS performance testing was completed in fiscal year (FY) 2008. Based on FY08 testing, the system is now in development to support an Exploration Life Support (ELS) Project distillation comparison test expected to begin in early 2009. As part of the project objectives planned for FY09, the system will be reconfigured to support the ELS comparison test. The CDS will then be challenged with a series of human-gene-rated waste streams representative of those anticipated for a lunar outpost. This paper provides a description of the CDS technology, a status of the current project activities, and data on the system s performance to date.

  17. Comparison of transient PCRV model test results with analysis

    Marchertas, A.H.; Belytschko, T.B.

    1979-01-01

    Comparisons are made of transient data derived from simple models of a reactor containment vessel with analytical solutions. This effort is a part of the ongoing process of development and testing of the DYNAPCON computer code. The test results used in these comparisons were obtained from scaled models of the British sodium cooled fast breeder program. The test structure is a scaled model of a cylindrically shaped reactor containment vessel made of concrete. This concrete vessel is prestressed axially by holddown bolts spanning the top and bottom slabs along the cylindrical walls, and is also prestressed circumferentially by a number of cables wrapped around the vessel. For test purposes this containment vessel is partially filled with water, which comes in direct contact with the vessel walls. The explosive charge is immersed in the pool of water and is centrally suspended from the top of the vessel. The tests are very similar to the series of tests made for the COVA experimental program, but the vessel here is the prestressed concrete container. (orig.)

  18. Testing Group Mean Differences of Latent Variables in Multilevel Data Using Multiple-Group Multilevel CFA and Multilevel MIMIC Modeling.

    Kim, Eun Sook; Cao, Chunhua

    2015-01-01

    Considering that group comparisons are common in social science, we examined two latent group mean testing methods when groups of interest were either at the between or within level of multilevel data: multiple-group multilevel confirmatory factor analysis (MG ML CFA) and multilevel multiple-indicators multiple-causes modeling (ML MIMIC). The performance of these methods were investigated through three Monte Carlo studies. In Studies 1 and 2, either factor variances or residual variances were manipulated to be heterogeneous between groups. In Study 3, which focused on within-level multiple-group analysis, six different model specifications were considered depending on how to model the intra-class group correlation (i.e., correlation between random effect factors for groups within cluster). The results of simulations generally supported the adequacy of MG ML CFA and ML MIMIC for multiple-group analysis with multilevel data. The two methods did not show any notable difference in the latent group mean testing across three studies. Finally, a demonstration with real data and guidelines in selecting an appropriate approach to multilevel multiple-group analysis are provided.

  19. Comparison of Parenting Style in Single Child and Multiple Children Families

    Masoumeh Alidosti; Seyedeh Leila Dehghani; Akbar Babaei-Heydarabadi; Elahe Tavassoli

    2016-01-01

    Background and Purpose: Family is the first and the most important structure in human civilization in which social lifestyles, mutual understanding, and compatibility is learned. Studies have shown that parenting style, is one the most important and fundamental factors in personality development. The purpose of this study was comparison of parenting style in single child and multiple children families. Materials and Methods: This study, in total, 152 mothers from Andimeshk city, Iran, wer...

  20. International Semiotics: Item Difficulty and the Complexity of Science Item Illustrations in the PISA-2009 International Test Comparison

    Solano-Flores, Guillermo; Wang, Chao; Shade, Chelsey

    2016-01-01

    We examined multimodality (the representation of information in multiple semiotic modes) in the context of international test comparisons. Using Program of International Student Assessment (PISA)-2009 data, we examined the correlation of the difficulty of science items and the complexity of their illustrations. We observed statistically…

  1. Evaluation and Comparison of the Position of the Apical Constriction in Single-root and Multiple-root Teeth

    Alireza Farhad

    2017-12-01

    Full Text Available Introduction: Precise knowledge of the location of the apical constriction is essential to root canal treatment and long-term prognosis. Considering the differences in the apical constriction and size of the roots in single- and multiple-root teeth in various races, examination and comparison of the location of the apical constriction in single-root and multiple-root teeth are of paramount importance. The present studies aimed to measure and compare the distance of the apical constriction from the apical foramen and anatomical apex in single-root and multiple-root teeth. Materials and Methods: In this cross-sectional study, 60 roots of single-rooted teeth and 60 roots of multiple-rooted teeth were collected from the patients referring to the health centers in Isfahan, Iran. After cleansing and disinfecting the surface of the roots, the surface of the teeth was washed with hypochlorite. Based on the direction of the apical foramen, a longitudinal cut was made in the same direction, and the roots were examined microscopically at the magnification of 25. Following that, the distance of the apical constriction from the apical foramen and anatomical apex was measured using a digital camera. In addition, mean and standard deviation of the obtained distance values were determined. Distances in the single-root and multiple-root teeth were compared using independent t-test, at the significance level of Results: Mean distance between the apical constriction and apical foramen was 0.86±0.33 mm in the single-root teeth and 0.072±0.27 mm in the multiple-root teeth. Mean distance between the apical constriction and anatomical apex was 1.14±0.36 mm in the single-root teeth and 1.03±0.36 mm in the multiple-root teeth. Moreover, the results of independent t-test showed the distance of the apical constriction from the apical foramen to be significant between single-root and multiple-rooted teeth (P=0.013. However, the distance between the apical constriction

  2. Multiple HEPA filter test methods, January--December 1976

    Schuster, B.; Kyle, T.; Osetek, D.

    1977-06-01

    The testing of tandem high-efficiency particulate air (HEPA) filter systems is of prime importance for the measurement of accurate overall system protection factors. A procedure, based on the use of an intra-cavity laser particle spectrometer, has been developed for measuring protection factors in the 10 8 range. A laboratory scale model of a filter system was constructed and initially tested to determine individual HEPA filter characteristics with regard to size and state (liquid or solid) of several test aerosols. Based on these laboratory measurements, in-situ testing has been successfully conducted on a number of single and tandem filter installations within the Los Alamos Scientific Laboratory as well as on extraordinary large single systems at Rocky Flats. For the purpose of recovery and for simplified solid waste disposal, or prefiltering purposes, two versions of an inhomogeneous electric field air cleaner have been devised and are undergoing testing. Initial experience with one of the systems, which relies on an electrostatic spraying phenomenon, indicates performance efficiency of greater than 99.9% for flow velocities commonly used in air cleaning systems. Among the effluents associated with nuclear fuel reprocessing is 129 I. An intra-cavity laser detection system is under development which shows promise of being able to detect mixing ratios of one part in 10 7 , I 2 in air

  3. Strategic alternatives ranking methodology: Multiple RCRA incinerator evaluation test case

    Baker, G.; Thomson, R.D.; Reece, J.; Springer, L.; Main, D.

    1988-01-01

    This paper presents an important process approach to permit quantification and ranking of multiple alternatives being considered in remedial actions or hazardous waste strategies. This process is a methodology for evaluating programmatic options in support of site selection or environmental analyses. Political or other less tangible motivations for alternatives may be quantified by means of establishing the range of significant variables, weighting their importance, and by establishing specific criteria for scoring individual alternatives. An application of the process to a recent AFLC program permitted ranking incineration alternatives from a list of over 130 options. The process forced participation by the organizations to be effected, allowed a consensus of opinion to be achieved, allowed complete flexibility to evaluate factor sensitivity, and resulted in strong, quantifiable support for any subsequent site-selection action NEPA documents

  4. Multiple Intelligences Profiles of Children with Attention Deficit and Hyperactivity Disorder in Comparison with Nonattention Deficit and Hyperactivity Disorder

    Mostafa Najafi

    2017-01-01

    Full Text Available Background: Attention deficit and hyperactivity disorder (ADHD is a common psychological problem during childhood. This study aimed to evaluate multiple intelligences profiles of children with ADHD in comparison with non-ADHD. Materials and Methods: This cross-sectional descriptive analytical study was done on 50 children of 6–13 years old in two groups of with and without ADHD. Children with ADHD were referred to Clinics of Child and Adolescent Psychiatry, Isfahan University of Medical Sciences, in 2014. Samples were selected based on clinical interview (based on Diagnostic and Statistical Manual of Mental Disorders IV and parent–teacher strengths and difficulties questionnaire, which was done by psychiatrist and psychologist. Raven intelligence quotient (IQ test was used, and the findings were compared to the results of multiple intelligences test. Data analysis was done using a multivariate analysis of covariance using SPSS20 software. Results: Comparing the profiles of multiple intelligence among two groups, there are more kinds of multiple intelligences in control group than ADHD group, a difference which has been more significant in logical, interpersonal, and intrapersonal intelligence (P 0.05. The IQ average score in the control group and ADHD group was 102.42 ± 16.26 and 96.72 ± 16.06, respectively, that reveals the negative effect of ADHD on IQ average value. There was an insignificance relationship between linguistic and naturalist intelligence (P > 0.05. However, in other kinds of multiple intelligences, direct and significant relationships were observed (P < 0.05. Conclusions: Since the levels of IQ (Raven test and MI in control group were more significant than ADHD group, ADHD is likely to be associated with logical-mathematical, interpersonal, and intrapersonal profiles.

  5. Empirical Comparison of Publication Bias Tests in Meta-Analysis.

    Lin, Lifeng; Chu, Haitao; Murad, Mohammad Hassan; Hong, Chuan; Qu, Zhiyong; Cole, Stephen R; Chen, Yong

    2018-04-16

    Decision makers rely on meta-analytic estimates to trade off benefits and harms. Publication bias impairs the validity and generalizability of such estimates. The performance of various statistical tests for publication bias has been largely compared using simulation studies and has not been systematically evaluated in empirical data. This study compares seven commonly used publication bias tests (i.e., Begg's rank test, trim-and-fill, Egger's, Tang's, Macaskill's, Deeks', and Peters' regression tests) based on 28,655 meta-analyses available in the Cochrane Library. Egger's regression test detected publication bias more frequently than other tests (15.7% in meta-analyses of binary outcomes and 13.5% in meta-analyses of non-binary outcomes). The proportion of statistically significant publication bias tests was greater for larger meta-analyses, especially for Begg's rank test and the trim-and-fill method. The agreement among Tang's, Macaskill's, Deeks', and Peters' regression tests for binary outcomes was moderately strong (most κ's were around 0.6). Tang's and Deeks' tests had fairly similar performance (κ > 0.9). The agreement among Begg's rank test, the trim-and-fill method, and Egger's regression test was weak or moderate (κ < 0.5). Given the relatively low agreement between many publication bias tests, meta-analysts should not rely on a single test and may apply multiple tests with various assumptions. Non-statistical approaches to evaluating publication bias (e.g., searching clinical trials registries, records of drug approving agencies, and scientific conference proceedings) remain essential.

  6. Multiple (Two) Met Bel 601 In Series Ultimate Vacuum Testing

    Restivo, M. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-09-30

    SRNL Environmental and Chemical Process Technology (E&CPT) was requested to perform testing of vacuum pumps per a verbal request from the Customer, SRNL Hydrogen Processing Technology. Tritium Operations is currently having difficulties procuring the Normetex™® Model 15 m3/hr (9 CFM) vacuum pump (formerly Normetex Pompes, now EumecaSARL). One possible solution proposed by Hydrogen Processing Technology personnel is to use two Senior Aerospace Metal Bellows MB-601 vacuum pumps piped with the heads in series, and the pumps in series (Figure 1 below). This memorandum documents the ultimate vacuum testing that was performed to determine if this concept was a viable alternate vacuum pump strategy. This testing dovetails with previous pump evaluations documented in references 1 and 2.

  7. Comparison of 200-liter and 40-milliliter leach tests

    Westsik, J.H. Jr.; Harvey, C.O.; Roberts, F.P.; Ross, W.A.; Thornhill, R.E.

    1982-01-01

    During the past year we have conducted a modified MCC-1 leach test on a 145 kg block of a cast cement waste form. The leach vessel was a 200 liter Teflon-lined drum and contained 97.5 liters of deionized water. The results of this large-scale leach test were compared with the results of standard MC-1 tests (40 ml) on smaller samples of the same waste form. The ratio of leachate volumes between the large and small scale tests was 2500 and the ratio of sample masses was 150,000. The cast cement samples for both tests contained plutonium-doped incinerator ash. The leachates from these tests were analyzed for both plutonium and the matrix elements. Evaluation of plutonium plateout in the large-scale test indicated that the majority of the plutonium leached from the samples deposits onto vessel walls and little ( -12 /sub M/) remains in solution. Comparison of elemental concentrations in the leachates indicates some differences up to 5X in the concentration in the large- and small-scale tests. The differences are attributed to differences in the solubilities of Ca, Si, and Fe at pH 11.5 and at pH 12.5. The higher pH observed for the large-scale test is a result of the larger quantities of sodium in the large block of cement

  8. Multiple sclerosis: Left advantage for auditory laterality in dichotic tests of central auditory processing and relationship of psychoacoustic tests with the Multiple Sclerosis Disability Scale-EDSS.

    Peñaloza López, Yolanda Rebeca; Orozco Peña, Xóchitl Daisy; Pérez Ruiz, Santiago Jesús

    2018-04-03

    To evaluate the central auditory processing disorders in patients with multiple sclerosis, emphasizing auditory laterality by applying psychoacoustic tests and to identify their relationship with the Multiple Sclerosis Disability Scale (EDSS) functions. Depression scales (HADS), EDSS, and 9 psychoacoustic tests to study CAPD were applied to 26 individuals with multiple sclerosis and 26 controls. Correlation tests were performed between the EDSS and psychoacoustic tests. Seven out of 9 psychoacoustic tests were significantly different (P<.05); right or left (14/19 explorations) with respect to control. In dichotic digits there was a left-ear advantage compared to the usual predominance of RDD. There was significant correlation in five psychoacoustic tests and the specific functions of EDSS. The left-ear advantage detected and interpreted as an expression of deficient influences of the corpus callosum and attention in multiple sclerosis should be investigated. There was a correlation between psychoacoustic tests and specific EDSS functions. Copyright © 2018 Sociedad Española de Otorrinolaringología y Cirugía de Cabeza y Cuello. Publicado por Elsevier España, S.L.U. All rights reserved.

  9. Multiple Maximum Exposure Rates in Computerized Adaptive Testing

    Ramon Barrada, Juan; Veldkamp, Bernard P.; Olea, Julio

    2009-01-01

    Computerized adaptive testing is subject to security problems, as the item bank content remains operative over long periods and administration time is flexible for examinees. Spreading the content of a part of the item bank could lead to an overestimation of the examinees' trait level. The most common way of reducing this risk is to impose a…

  10. Multiple Score Comparison: a network meta-analysis approach to comparison and external validation of prognostic scores

    Sarah R. Haile

    2017-12-01

    Full Text Available Abstract Background Prediction models and prognostic scores have been increasingly popular in both clinical practice and clinical research settings, for example to aid in risk-based decision making or control for confounding. In many medical fields, a large number of prognostic scores are available, but practitioners may find it difficult to choose between them due to lack of external validation as well as lack of comparisons between them. Methods Borrowing methodology from network meta-analysis, we describe an approach to Multiple Score Comparison meta-analysis (MSC which permits concurrent external validation and comparisons of prognostic scores using individual patient data (IPD arising from a large-scale international collaboration. We describe the challenges in adapting network meta-analysis to the MSC setting, for instance the need to explicitly include correlations between the scores on a cohort level, and how to deal with many multi-score studies. We propose first using IPD to make cohort-level aggregate discrimination or calibration scores, comparing all to a common comparator. Then, standard network meta-analysis techniques can be applied, taking care to consider correlation structures in cohorts with multiple scores. Transitivity, consistency and heterogeneity are also examined. Results We provide a clinical application, comparing prognostic scores for 3-year mortality in patients with chronic obstructive pulmonary disease using data from a large-scale collaborative initiative. We focus on the discriminative properties of the prognostic scores. Our results show clear differences in performance, with ADO and eBODE showing higher discrimination with respect to mortality than other considered scores. The assumptions of transitivity and local and global consistency were not violated. Heterogeneity was small. Conclusions We applied a network meta-analytic methodology to externally validate and concurrently compare the prognostic properties

  11. ISP42 (PANDA Tests) - Open Phase Comparison Report

    2003-05-01

    PANDA is a large-scale facility, which has been constructed at the Paul Scherrer Institute (PSI) for the investigation of both overall dynamic response and the key phenomena of passive containment systems during the long-term heat removal phase for Advanced Light Water Reactors (ALWRs). Using a modular concept with a basic set of cylindrical vessels and connecting piping, the facility can be adapted to simulate different passive containment designs. Following a proposal, the OECD/NEA Committee on the Safety of Nuclear Installations approved, at its meeting on December 3-5, 1997, a new International Standard Problem (ISP) involving a test in the PANDA facility, based on a recommendation from the Principal Working Group 2 (PWG2) on System Behaviour. The main interest for this ISP is code validation in relation to a range of LWR and advanced LWR (ALWR) (mainly) containment issues that have been designated as important and involving thermalhydraulic phenomena. The ISP-PANDA test for defined six phases (A to F) was performed on 21/22 April 1998. Since the first part of ISP-42 was going to be conducted as a 'double- blind' or 'blind' exercise, the experimental data was locked. The 'blind' phase calculational results compared to experimental data are presented in the report entitled 'ISP-42 (PANDA Tests ) Blind Phase Comparison'. In the second part, the 'open' exercise has been conducted by providing the ISP-42 PANDA test data to the participants and by performing post-test analysis. The results of the 'open' phase are presented in the present report. 'Open' phase submissions, comparisons, and analyses for ISP-42 are based on the outcome of the results presented in the 'blind' phase report of ISP-42. The experimental data was distributed to all ISP-42 participants for their post-test calculations, 20 June 2000. 'Open' phase analyses of some of the ISP-42 participants, were completely received by the end of January 2001. There were 27 new submissions for different phases

  12. Comparison of likelihood testing procedures for parallel systems with covariances

    Ayman Baklizi; Isa Daud; Noor Akma Ibrahim

    1998-01-01

    In this paper we considered investigating and comparing the behavior of the likelihood ratio, the Rao's and the Wald's statistics for testing hypotheses on the parameters of the simple linear regression model based on parallel systems with covariances. These statistics are asymptotically equivalent (Barndorff-Nielsen and Cox, 1994). However, their relative performances in finite samples are generally known. A Monte Carlo experiment is conducted to stimulate the sizes and the powers of these statistics for complete samples and in the presence of time censoring. Comparisons of the statistics are made according to the attainment of assumed size of the test and their powers at various points in the parameter space. The results show that the likelihood ratio statistics appears to have the best performance in terms of the attainment of the assumed size of the test. Power comparisons show that the Rao statistic has some advantage over the Wald statistic in almost all of the space of alternatives while likelihood ratio statistic occupies either the first or the last position in term of power. Overall, the likelihood ratio statistic appears to be more appropriate to the model under study, especially for small sample sizes

  13. Comparison of high efficiency particulate filter testing methods

    1985-01-01

    High Efficiency Particulate Air (HEPA) filters are used for the removal of submicron size particulates from air streams. In nuclear industry they are used as an important engineering safeguard to prevent the release of air borne radioactive particulates to the environment. HEPA filters used in the nuclear industry should therefore be manufactured and operated under strict quality control. There are three levels of testing HEPA filters: i) testing of the filter media; ii) testing of the assembled filter including filter media and filter housing; and iii) on site testing of the complete filter installation before putting into operation and later for the purpose of periodic control. A co-ordinated research programme on particulate filter testing methods was taken up by the Agency and contracts were awarded to the Member Countries, Belgium, German Democratic Republic, India and Hungary. The investigations carried out by the participants of the present co-ordinated research programme include the results of the nowadays most frequently used HEPA filter testing methods both for filter medium test, rig test and in-situ test purposes. Most of the experiments were carried out at ambient temperature and humidity, but indications were given to extend the investigations to elevated temperature and humidity in the future for the purpose of testing the performance of HEPA filter under severe conditions. A major conclusion of the co-ordinated research programme was that it was not possible to recommend one method as a reference method for in situ testing of high efficiency particulate air filters. Most of the present conventional methods are adequate for current requirements. The reasons why no method is to be recommended were multiple, ranging from economical aspects, through incompatibility of materials to national regulations

  14. Testing effect of a drug using multiple nested models for the dose–response

    Baayen, C.; Hougaard, P.; Pipper, C. B.

    2015-01-01

    of the assumed dose–response model. Bretz et al. (2005, Biometrics 61, 738–748) suggested a combined approach, which selects one or more suitable models from a set of candidate models using a multiple comparison procedure. The method initially requires a priori estimates of any non-linear parameters...

  15. Comparison of Test and Finite Element Analysis for Two Full-Scale Helicopter Crash Tests

    Annett, Martin S.; Horta,Lucas G.

    2011-01-01

    Finite element analyses have been performed for two full-scale crash tests of an MD-500 helicopter. The first crash test was conducted to evaluate the performance of a composite deployable energy absorber under combined flight loads. In the second crash test, the energy absorber was removed to establish the baseline loads. The use of an energy absorbing device reduced the impact acceleration levels by a factor of three. Accelerations and kinematic data collected from the crash tests were compared to analytical results. Details of the full-scale crash tests and development of the system-integrated finite element model are briefly described along with direct comparisons of acceleration magnitudes and durations for the first full-scale crash test. Because load levels were significantly different between tests, models developed for the purposes of predicting the overall system response with external energy absorbers were not adequate under more severe conditions seen in the second crash test. Relative error comparisons were inadequate to guide model calibration. A newly developed model calibration approach that includes uncertainty estimation, parameter sensitivity, impact shape orthogonality, and numerical optimization was used for the second full-scale crash test. The calibrated parameter set reduced 2-norm prediction error by 51% but did not improve impact shape orthogonality.

  16. The comparison between science virtual and paper based test in measuring grade 7 students’ critical thinking

    Dhitareka, P. H.; Firman, H.; Rusyati, L.

    2018-05-01

    This research is comparing science virtual and paper-based test in measuring grade 7 students’ critical thinking based on Multiple Intelligences and gender. Quasi experimental method with within-subjects design is conducted in this research in order to obtain the data. The population of this research was all seventh grade students in ten classes of one public secondary school in Bandung. There were 71 students within two classes taken randomly became the sample in this research. The data are obtained through 28 questions with a topic of living things and environmental sustainability constructed based on eight critical thinking elements proposed by Inch then the questions provided in science virtual and paper-based test. The data was analysed by using paired-samples t test when the data are parametric and Wilcoxon signed ranks test when the data are non-parametric. In general comparison, the p-value of the comparison between science virtual and paper-based tests’ score is 0.506, indicated that there are no significance difference between science virtual and paper-based test based on the tests’ score. The results are furthermore supported by the students’ attitude result which is 3.15 from the scale from 1 to 4, indicated that they have positive attitudes towards Science Virtual Test.

  17. Principal permeability determination from multiple horizontal well tests

    Economides, M. [Texas A and M Univ., TX (United States); Munoz, A.; Ehlig-Economides, C.

    1998-12-31

    A method for obtaining principal permeability magnitudes and direction that requires only the linear flow regime from transient tests in three horizontal wells oriented in three distinct and arbitrary directions, is described. Well design optimization strategies require knowledge of both the principal permeability orientation as well as the horizontal permeability magnitudes. When the degree of horizontal permeability anisotropy (i.e. permeability in the bedding plane with respect to direction) is significant, the productivity of a long horizontal well will depend greatly on its direction, especially when the well is first brought into production. Productivities have been found to deviate substantially among wells in the same reservoir and this deviation has been attributed to differences in well orientation. In view of this fact, measuring permeability anisotropy becomes a compelling necessity. The success of the proposed method is illustrated by a case study in which the principal permeability magnitudes and direction from three wells were used to predict the productivity of a fourth well within 10 per cent. Use of the computed principal permeabilities from the case study, it was possible to forecast the cumulative production to show the significance of well trajectory optimization on the discounted cash flow and the net present value. 20 refs., 3 figs.

  18. Comparison of Masking Level Difference in Patients with Multiple Sclerosis and Healthy Control Group

    Soghrat Faghihzadeh

    2012-03-01

    Full Text Available Background and Aim: Multiple sclerosis (MS is a neurological disorder that involves central nervous system. Studies have showed that multiple sclerosis affects behavioral central auditory tests, such as masking release or masking level difference (MLD. The purpose of this study is to compare the masking level difference between multiple sclerosis patients and normal subjects.Methods: This cross sectional and non-interventional study was conducted on 32 multiple sclerosis patients aged between 20-50 years and 32 controls matched for age and gender in Faculty of Rehabilitation, Tehran University of Medical Sciences. masking level difference test was performed on each subject.Results: The mean masking level difference in the two groups was significantly different (p<0.01 however, gender did not prove to play a role in this difference.Conclusion: As part of the multiple sclerosis diagnosis panel, masking level difference test is an efficient modality for evaluation of hearing impairment and monitoring of rehabilitation progress.

  19. More Than Just Accuracy: A Novel Method to Incorporate Multiple Test Attributes in Evaluating Diagnostic Tests Including Point of Care Tests.

    Thompson, Matthew; Weigl, Bernhard; Fitzpatrick, Annette; Ide, Nicole

    2016-01-01

    Current frameworks for evaluating diagnostic tests are constrained by a focus on diagnostic accuracy, and assume that all aspects of the testing process and test attributes are discrete and equally important. Determining the balance between the benefits and harms associated with new or existing tests has been overlooked. Yet, this is critically important information for stakeholders involved in developing, testing, and implementing tests. This is particularly important for point of care tests (POCTs) where tradeoffs exist between numerous aspects of the testing process and test attributes. We developed a new model that multiple stakeholders (e.g., clinicians, patients, researchers, test developers, industry, regulators, and health care funders) can use to visualize the multiple attributes of tests, the interactions that occur between these attributes, and their impacts on health outcomes. We use multiple examples to illustrate interactions between test attributes (test availability, test experience, and test results) and outcomes, including several POCTs. The model could be used to prioritize research and development efforts, and inform regulatory submissions for new diagnostics. It could potentially provide a way to incorporate the relative weights that various subgroups or clinical settings might place on different test attributes. Our model provides a novel way that multiple stakeholders can use to visualize test attributes, their interactions, and impacts on individual and population outcomes. We anticipate that this will facilitate more informed decision making around diagnostic tests.

  20. DHS small-scale safety and thermal testing of improvised explosives-comparison of testing performance

    Reynolds, J G; Hsu, P C; Sandstrom, M M; Brown, G W; Warner, K F; Phillips, J J; Shelley, T J; Reyes, J A

    2014-01-01

    One of the first steps in establishing safe handling procedures for explosives is small-scale safety and thermal (SSST) testing. To better understand the response of improvised materials or homemade explosives (HMEs) to SSST testing, 16 HME materials were compared to three standard military explosives in a proficiency-type round robin study among five laboratories-two DoD and three DOE-sponsored by DHS. The testing matrix has been designed to address problems encountered with improvised materials-powder mixtures, liquid suspensions, partially wetted solids, immiscible liquids, and reactive materials. More than 30 issues have been identified that indicate standard test methods may require modification when applied to HMEs to derive accurate sensitivity assessments needed for developing safe handling and storage practices. This paper presents a generalized comparison of the results among the testing participants, comparison of friction results from BAM (German Bundesanstalt für Materi-alprüfung) and ABL (Allegany Ballistics Laboratory) designed testing equipment, and an overview of the statistical results from the RDX (1,3,5-Trinitroperhydro-1,3,5-triazine) standard tested throughout the proficiency test.

  1. Comparison of sensitivity of magnetic resonance imaging and evoked potentials in the detection of brainstem involvement in multiple sclerosis

    Comi, G.; Martinelli, V.; Medaglini, S.; Locatelli, T.; Magnani, G.; Poggi, A.; Triulzi, F.

    1988-01-01

    A comparison was made of the sensitivity of magnetic resonance imaging and the combined use of Brainstem Auditory Evoked Potential and Median Somatosensory Evoked Potential in the detection of brainstem dysfunction in 54 multiple sclerosis patients. 10 refs.; 2 tabs

  2. Accelerating Multiple Compound Comparison Using LINGO-Based Load-Balancing Strategies on Multi-GPUs.

    Lin, Chun-Yuan; Wang, Chung-Hung; Hung, Che-Lun; Lin, Yu-Shiang

    2015-01-01

    Compound comparison is an important task for the computational chemistry. By the comparison results, potential inhibitors can be found and then used for the pharmacy experiments. The time complexity of a pairwise compound comparison is O(n (2)), where n is the maximal length of compounds. In general, the length of compounds is tens to hundreds, and the computation time is small. However, more and more compounds have been synthesized and extracted now, even more than tens of millions. Therefore, it still will be time-consuming when comparing with a large amount of compounds (seen as a multiple compound comparison problem, abbreviated to MCC). The intrinsic time complexity of MCC problem is O(k (2) n (2)) with k compounds of maximal length n. In this paper, we propose a GPU-based algorithm for MCC problem, called CUDA-MCC, on single- and multi-GPUs. Four LINGO-based load-balancing strategies are considered in CUDA-MCC in order to accelerate the computation speed among thread blocks on GPUs. CUDA-MCC was implemented by C+OpenMP+CUDA. CUDA-MCC achieved 45 times and 391 times faster than its CPU version on a single NVIDIA Tesla K20m GPU card and a dual-NVIDIA Tesla K20m GPU card, respectively, under the experimental results.

  3. Accelerating Multiple Compound Comparison Using LINGO-Based Load-Balancing Strategies on Multi-GPUs

    Chun-Yuan Lin

    2015-01-01

    Full Text Available Compound comparison is an important task for the computational chemistry. By the comparison results, potential inhibitors can be found and then used for the pharmacy experiments. The time complexity of a pairwise compound comparison is O(n2, where n is the maximal length of compounds. In general, the length of compounds is tens to hundreds, and the computation time is small. However, more and more compounds have been synthesized and extracted now, even more than tens of millions. Therefore, it still will be time-consuming when comparing with a large amount of compounds (seen as a multiple compound comparison problem, abbreviated to MCC. The intrinsic time complexity of MCC problem is O(k2n2 with k compounds of maximal length n. In this paper, we propose a GPU-based algorithm for MCC problem, called CUDA-MCC, on single- and multi-GPUs. Four LINGO-based load-balancing strategies are considered in CUDA-MCC in order to accelerate the computation speed among thread blocks on GPUs. CUDA-MCC was implemented by C+OpenMP+CUDA. CUDA-MCC achieved 45 times and 391 times faster than its CPU version on a single NVIDIA Tesla K20m GPU card and a dual-NVIDIA Tesla K20m GPU card, respectively, under the experimental results.

  4. Hydrologic test plans for large-scale, multiple-well tests in support of site characterization at Hanford, Washington

    Rogers, P.M.; Stone, R.; Lu, A.H.

    1985-01-01

    The Basalt Waste Isolation Project is preparing plans for tests and has begun work on some tests that will provide the data necessary for the hydrogeologic characterization of a site located on a United States government reservation at Hanford, Washington. This site is being considered for the Nation's first geologic repository of high level nuclear waste. Hydrogeologic characterization of this site requires several lines of investigation which include: surface-based small-scale tests, testing performed at depth from an exploratory shaft, geochemistry investigations, regional studies, and site-specific investigations using large-scale, multiple-well hydraulic tests. The large-scale multiple-well tests are planned for several locations in and around the site. These tests are being designed to provide estimates of hydraulic parameter values of the geologic media, chemical properties of the groundwater, and hydrogeologic boundary conditions at a scale appropriate for evaluating repository performance with respect to potential radionuclide transport

  5. Analysing earthquake slip models with the spatial prediction comparison test

    Zhang, L.; Mai, Paul Martin; Thingbaijam, Kiran Kumar; Razafindrakoto, H. N. T.; Genton, Marc G.

    2014-01-01

    Earthquake rupture models inferred from inversions of geophysical and/or geodetic data exhibit remarkable variability due to uncertainties in modelling assumptions, the use of different inversion algorithms, or variations in data selection and data processing. A robust statistical comparison of different rupture models obtained for a single earthquake is needed to quantify the intra-event variability, both for benchmark exercises and for real earthquakes. The same approach may be useful to characterize (dis-)similarities in events that are typically grouped into a common class of events (e.g. moderate-size crustal strike-slip earthquakes or tsunamigenic large subduction earthquakes). For this purpose, we examine the performance of the spatial prediction comparison test (SPCT), a statistical test developed to compare spatial (random) fields by means of a chosen loss function that describes an error relation between a 2-D field (‘model’) and a reference model. We implement and calibrate the SPCT approach for a suite of synthetic 2-D slip distributions, generated as spatial random fields with various characteristics, and then apply the method to results of a benchmark inversion exercise with known solution. We find the SPCT to be sensitive to different spatial correlations lengths, and different heterogeneity levels of the slip distributions. The SPCT approach proves to be a simple and effective tool for ranking the slip models with respect to a reference model.

  6. Analysing earthquake slip models with the spatial prediction comparison test

    Zhang, L.

    2014-11-10

    Earthquake rupture models inferred from inversions of geophysical and/or geodetic data exhibit remarkable variability due to uncertainties in modelling assumptions, the use of different inversion algorithms, or variations in data selection and data processing. A robust statistical comparison of different rupture models obtained for a single earthquake is needed to quantify the intra-event variability, both for benchmark exercises and for real earthquakes. The same approach may be useful to characterize (dis-)similarities in events that are typically grouped into a common class of events (e.g. moderate-size crustal strike-slip earthquakes or tsunamigenic large subduction earthquakes). For this purpose, we examine the performance of the spatial prediction comparison test (SPCT), a statistical test developed to compare spatial (random) fields by means of a chosen loss function that describes an error relation between a 2-D field (‘model’) and a reference model. We implement and calibrate the SPCT approach for a suite of synthetic 2-D slip distributions, generated as spatial random fields with various characteristics, and then apply the method to results of a benchmark inversion exercise with known solution. We find the SPCT to be sensitive to different spatial correlations lengths, and different heterogeneity levels of the slip distributions. The SPCT approach proves to be a simple and effective tool for ranking the slip models with respect to a reference model.

  7. Comparison of transient PCRV model test results with analysis

    Marchertas, A.H.; Belytschko, T.B.

    1979-01-01

    Comparisons are made of transient data derived from simple models of a reactor containment vessel with analytical solutions. This effort is a part of the ongoing process of development and testing of the DYNAPCON computer code. The test results used in these comparisons were obtained from scaled models of the British sodium cooled fast breeder program. The test structure is a scaled model of a cylindrically shaped reactor containment vessel made of concrete. This concrete vessel is prestressed axially by holddown bolts spanning the top and bottom slabs along the cylindrical walls, and is also prestressed circumferentially by a number of cables wrapped around the vessel. For test purposes this containment vessel is partially filled with water, which comes in direct contact with the vessel walls. The explosive charge is immersed in the pool of water and is centrally suspended from the top of the vessel. The load history was obtained from an ICECO analysis, using the equations of state for the source and the water. A detailed check of this solution was made to assure that the derived loading did provide the correct input. The DYNAPCON code was then used for the analysis of the prestressed concrete containment model. This analysis required the simulation of prestressing and the response of the model to the applied transient load. The calculations correctly predict the magnitudes of displacements of the PCRV model. In addition, the displacement time histories obtained from the calculations reproduce the general features of the experimental records: the period elongation and amplitude increase as compared to an elastic solution, and also the absence of permanent displacement. However, the period still underestimates the experiment, while the amplitude is generally somewhat large

  8. Published GMO studies find no evidence of harm when corrected for multiple comparisons.

    Panchin, Alexander Y; Tuzhikov, Alexander I

    2017-03-01

    A number of widely debated research articles claiming possible technology-related health concerns have influenced the public opinion on genetically modified food safety. We performed a statistical reanalysis and review of experimental data presented in some of these studies and found that quite often in contradiction with the authors' conclusions the data actually provides weak evidence of harm that cannot be differentiated from chance. In our opinion the problem of statistically unaccounted multiple comparisons has led to some of the most cited anti-genetically modified organism health claims in history. We hope this analysis puts the original results of these studies into proper context.

  9. Simultaneous small-sample comparisons in longitudinal or multi-endpoint trials using multiple marginal models

    Pallmann, Philip; Ritz, Christian; Hothorn, Ludwig A

    2018-01-01

    , however only asymptotically. In this paper, we show how to make the approach also applicable to small-sample data problems. Specifically, we discuss the computation of adjusted P values and simultaneous confidence bounds for comparisons of randomised treatment groups as well as for levels......Simultaneous inference in longitudinal, repeated-measures, and multi-endpoint designs can be onerous, especially when trying to find a reasonable joint model from which the interesting effects and covariances are estimated. A novel statistical approach known as multiple marginal models greatly...... simplifies the modelling process: the core idea is to "marginalise" the problem and fit multiple small models to different portions of the data, and then estimate the overall covariance matrix in a subsequent, separate step. Using these estimates guarantees strong control of the family-wise error rate...

  10. Comparison of Deep Learning With Multiple Machine Learning Methods and Metrics Using Diverse Drug Discovery Data Sets.

    Korotcov, Alexandru; Tkachenko, Valery; Russo, Daniel P; Ekins, Sean

    2017-12-04

    Machine learning methods have been applied to many data sets in pharmaceutical research for several decades. The relative ease and availability of fingerprint type molecular descriptors paired with Bayesian methods resulted in the widespread use of this approach for a diverse array of end points relevant to drug discovery. Deep learning is the latest machine learning algorithm attracting attention for many of pharmaceutical applications from docking to virtual screening. Deep learning is based on an artificial neural network with multiple hidden layers and has found considerable traction for many artificial intelligence applications. We have previously suggested the need for a comparison of different machine learning methods with deep learning across an array of varying data sets that is applicable to pharmaceutical research. End points relevant to pharmaceutical research include absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) properties, as well as activity against pathogens and drug discovery data sets. In this study, we have used data sets for solubility, probe-likeness, hERG, KCNQ1, bubonic plague, Chagas, tuberculosis, and malaria to compare different machine learning methods using FCFP6 fingerprints. These data sets represent whole cell screens, individual proteins, physicochemical properties as well as a data set with a complex end point. Our aim was to assess whether deep learning offered any improvement in testing when assessed using an array of metrics including AUC, F1 score, Cohen's kappa, Matthews correlation coefficient and others. Based on ranked normalized scores for the metrics or data sets Deep Neural Networks (DNN) ranked higher than SVM, which in turn was ranked higher than all the other machine learning methods. Visualizing these properties for training and test sets using radar type plots indicates when models are inferior or perhaps over trained. These results also suggest the need for assessing deep learning further

  11. On the Equivalence of Constructed-Response and Multiple-Choice Tests.

    Traub, Ross E.; Fisher, Charles W.

    Two sets of mathematical reasoning and two sets of verbal comprehension items were cast into each of three formats--constructed response, standard multiple-choice, and Coombs multiple-choice--in order to assess whether tests with indentical content but different formats measure the same attribute, except for possible differences in error variance…

  12. Within-day variability on short and long walking tests in persons with multiple sclerosis

    Feys, P.; Bibby, B.; Romberg, A.; Santoyo, C.; Gebara, B.; de Noordhout, B.M.; Knuts, K.; Bethoux, F.; Skjerbaek, A.; Jensen, E.; Baert, I.; Vaney, C.; de Groot, V.; Dalgas, U.

    2014-01-01

    Objective To compare within-day variability of short (10 m walking test at usual and fastest speed; 10MWT) and long (2 and 6-minute walking test; 2MWT/6MWT) tests in persons with multiple sclerosis. Design Observational study. Setting MS rehabilitation and research centers in Europe and US within

  13. Comparison of multiple crystal structures with NMR data for engrailed homeodomain

    Religa, Tomasz L. [MRC Centre for Protein Engineering (United Kingdom)], E-mail: tlr25@mrc-lmb.cam.ac.uk

    2008-03-15

    Two methods are currently available to solve high resolution protein structures-X-ray crystallography and nuclear magnetic resonance (NMR). Both methods usually produce highly similar structures, but small differences between both solutions are always observed. Here the raw NMR data as well as the solved NMR structure were compared to the multiple crystal structures solved for the WT 60 residue three helix bundle engrailed homeodomain (EnHD) and single point mutants. There was excellent agreement between TALOS-predicted and crystal structure-observed dihedral angles and a good agreement for the {sup 3}J(H{sup N}H{sup {alpha}}) couplings for the multiple crystal structures. Around 1% of NOEs were violated for any crystal structure, but no NOE was inconsistent with all of the crystal structures. Violations usually occurred for surface residues or for residues for which multiple discreet conformations were observed between the crystal structures. Comparison of the disorder shown in the multiple crystal structures shows little correlation with dynamics under native conditions for this protein.

  14. All of the above: When multiple correct response options enhance the testing effect.

    Bishara, Anthony J; Lanzo, Lauren A

    2015-01-01

    Previous research has shown that multiple choice tests often improve memory retention. However, the presence of incorrect lures often attenuates this memory benefit. The current research examined the effects of "all of the above" (AOTA) options. When such options are correct, no incorrect lures are present. In the first three experiments, a correct AOTA option on an initial test led to a larger memory benefit than no test and standard multiple choice test conditions. The benefits of a correct AOTA option occurred even without feedback on the initial test; for both 5-minute and 48-hour retention delays; and for both cued recall and multiple choice final test formats. In the final experiment, an AOTA question led to better memory retention than did a control condition that had identical timing and exposure to response options. However, the benefits relative to this control condition were similar regardless of the type of multiple choice test (AOTA or not). Results suggest that retrieval contributes to multiple choice testing effects. However, the extra testing effect from a correct AOTA option, rather than being due to more retrieval, might be due simply to more exposure to correct information.

  15. Validity of multiple stress creep recovery test for LADOTD asphalt binder specification.

    2010-09-01

    The objectives of this research are to characterize the elastic response of various binders used by LADOTD to determine the feasibility of the Multiple Stress Creep Recovery (MSCR) test to be included in the LADOTD asphalt binder specification and to...

  16. Using automatic item generation to create multiple-choice test items.

    Gierl, Mark J; Lai, Hollis; Turner, Simon R

    2012-08-01

    Many tests of medical knowledge, from the undergraduate level to the level of certification and licensure, contain multiple-choice items. Although these are efficient in measuring examinees' knowledge and skills across diverse content areas, multiple-choice items are time-consuming and expensive to create. Changes in student assessment brought about by new forms of computer-based testing have created the demand for large numbers of multiple-choice items. Our current approaches to item development cannot meet this demand. We present a methodology for developing multiple-choice items based on automatic item generation (AIG) concepts and procedures. We describe a three-stage approach to AIG and we illustrate this approach by generating multiple-choice items for a medical licensure test in the content area of surgery. To generate multiple-choice items, our method requires a three-stage process. Firstly, a cognitive model is created by content specialists. Secondly, item models are developed using the content from the cognitive model. Thirdly, items are generated from the item models using computer software. Using this methodology, we generated 1248 multiple-choice items from one item model. Automatic item generation is a process that involves using models to generate items using computer technology. With our method, content specialists identify and structure the content for the test items, and computer technology systematically combines the content to generate new test items. By combining these outcomes, items can be generated automatically. © Blackwell Publishing Ltd 2012.

  17. Response of HDR-VKL piping system to seismic test excitations: Comparison of analytical predictions and test measurements

    Srinivasan, M.G.; Kot, C.A.; Hsieh, B.J.

    1989-01-01

    As part of the earthquake investigations at the HDR (Heissdampfreaktor) Test Facility in Kahl/Main, FRG, simulated seismic tests (SHAM) were performed during April--May 1988 on the VKL (Versuchskreislauf) piping system. The purpose of these experiments was to study the behavior of piping subjected to a range of seismic excitation levels including those that exceed design levels manifold and that might induce failure of pipe supports or plasticity in the pipe runs, and to establish seismic margins for piping and pipe supports. Data obtained in the tests are also used to validate analysis methods. Detailed reports on the SHAM experiments are given elsewhere. The objective of this document is to evaluate a subsystem analysis module of the SMACS code. This module is a linear finite-element based program capable of calculating the response of nuclear power plant subsystems subjected to independent multiple-acceleration input excitation. The evaluation is based on a comparison of computational results of simulation of SHAM tests with corresponding test measurements

  18. Automated Testing Infrastructure and Result Comparison for Geodynamics Codes

    Heien, E. M.; Kellogg, L. H.

    2013-12-01

    The geodynamics community uses a wide variety of codes on a wide variety of both software and hardware platforms to simulate geophysical phenomenon. These codes are generally variants of finite difference or finite element calculations involving Stokes flow or wave propagation. A significant problem is that codes of even low complexity will return different results depending on the platform due to slight differences in hardware, software, compiler, and libraries. Furthermore, changes to the codes during development may affect solutions in unexpected ways such that previously validated results are altered. The Computational Infrastructure for Geodynamics (CIG) is funded by the NSF to enhance the capabilities of the geodynamics community through software development. CIG has recently done extensive work in setting up an automated testing and result validation system based on the BaTLab system developed at the University of Wisconsin, Madison. This system uses 16 variants of Linux and Mac platforms on both 32 and 64-bit processors to test several CIG codes, and has also recently been extended to support testing on the XSEDE TACC (Texas Advanced Computing Center) Stampede cluster. In this work we overview the system design and demonstrate how automated testing and validation occurs and results are reported. We also examine several results from the system from different codes and discuss how changes in compilers and libraries affect the results. Finally we detail some result comparison tools for different types of output (scalar fields, velocity fields, seismogram data), and discuss within what margins different results can be considered equivalent.

  19. Functional Magnetic Resonance Imaging with Concurrent Urodynamic Testing Identifies Brain Structures Involved in Micturition Cycle in Patients with Multiple Sclerosis.

    Khavari, Rose; Karmonik, Christof; Shy, Michael; Fletcher, Sophie; Boone, Timothy

    2017-02-01

    Neurogenic lower urinary tract dysfunction, which is common in patients with multiple sclerosis, has a significant impact on quality of life. In this study we sought to determine brain activity processes during the micturition cycle in female patients with multiple sclerosis and neurogenic lower urinary tract dysfunction. We report brain activity on functional magnetic resonance imaging and simultaneous urodynamic testing in 23 ambulatory female patients with multiple sclerosis. Individual functional magnetic resonance imaging activation maps at strong desire to void and at initiation of voiding were calculated and averaged at Montreal Neuroimaging Institute. Areas of significant activation were identified in these average maps. Subgroup analysis was performed in patients with elicitable neurogenic detrusor overactivity or detrusor-sphincter dyssynergia. Group analysis of all patients at strong desire to void yielded areas of activation in regions associated with executive function (frontal gyrus), emotional regulation (cingulate gyrus) and motor control (putamen, cerebellum and precuneus). Comparison of the average change in activation between previously reported healthy controls and patients with multiple sclerosis showed predominantly stronger, more focal activation in the former and lower, more diffused activation in the latter. Patients with multiple sclerosis who had demonstrable neurogenic detrusor overactivity and detrusor-sphincter dyssynergia showed a trend toward distinct brain activation at full urge and at initiation of voiding respectively. We successfully studied brain activation during the entire micturition cycle in female patients with neurogenic lower urinary tract dysfunction and multiple sclerosis using a concurrent functional magnetic resonance imaging/urodynamic testing platform. Understanding the central neural processes involved in specific parts of micturition in patients with neurogenic lower urinary tract dysfunction may identify areas

  20. The hippocampus supports multiple cognitive processes through relational binding and comparison

    Rosanna Kathleen Olsen

    2012-05-01

    Full Text Available It has been well established that the hippocampus plays a pivotal role in explicit long-term recognition memory. However, findings from amnesia, lesion and recording studies with non-human animals, eye-movement recording studies, and functional neuroimaging have recently converged upon a similar message: the functional reach of the hippocampus extends far beyond explicit recognition memory. Damage to the hippocampus affects performance on a number of cognitive tasks including recognition memory after short and long delays and visual discrimination. Additionally, with the advent of neuroimaging techniques that have fine spatial and temporal resolution, findings have emerged that show the elicitation of hippocampal responses within the first few hundred milliseconds of stimulus/task onset. These responses occur for novel and previously viewed information during a time when perceptual processing is traditionally thought to occur, and long before overt recognition responses are made. We propose that the hippocampus is obligatorily involved in the binding of disparate elements across both space and time, and in the comparison of such relational memory representations. Furthermore, the hippocampus supports relational binding and comparison with or without conscious awareness for the relational representations that are formed, retrieved and/or compared. It is by virtue of these basic binding and comparison functions that the reach of the hippocampus extends beyond long-term recognition memory and underlies task performance in multiple cognitive domains.

  1. A simplified approach for evaluating multiple test outcomes and multiple disease states in relation to the exercise thallium-201 stress test in suspected coronary artery disease

    Pollock, S.G.; Watson, D.D.; Gibson, R.S.; Beller, G.A.; Kaul, S.

    1989-01-01

    This study describes a simplified approach for the interpretation of electrocardiographic and thallium-201 imaging data derived from the same patient during exercise. The 383 patients in this study had also undergone selective coronary arteriography within 3 months of the exercise test. This matrix approach allows for multiple test outcomes (both tests positive, both negative, 1 test positive and 1 negative) and multiple disease states (no coronary artery disease vs 1-vessel vs multivessel coronary artery disease). Because this approach analyzes the results of 2 test outcomes simultaneously rather than serially, it also negates the lack of test independence, if such an effect is present. It is also demonstrated that ST-segment depression on the electrocardiogram and defects on initial thallium-201 images provide conditionally independent information regarding the presence of coronary artery disease in patients without prior myocardial infarction. In contrast, ST-segment depression on the electrocardiogram and redistribution on the delayed thallium-201 images may not provide totally independent information regarding the presence of exercise-induced ischemia in patients with or without myocardial infarction

  2. Comparison of the automated vision screening test to the Snellen test.

    Gofin, R; Falk, M

    1991-03-01

    The comparison of an automatic vision screening machine using the Landolt rings and the usual Snellen Chart was carried out among 123 second grade and 149 fifth grade students in an elementary school in Jerusalem. The sensitivity of the test for a cut-off point of greater than or equal to 6/12 according to the Snellen test was 41.7% (CI = 16.5-71.4) and the specificity was 86.5% (CI 78.1-92.2) for second graders. For fifth graders the values were 50.0% (CI = 20.1-79.9) and 90.6% (CI 83.7-94.8) respectively. Diagnosis by a specialist decreased the number of 'false negatives' and confirmed the pathological cases. The automatic test was well accepted by the children. Though more time is needed for assessment using the automatic test, its advantage is that no professional staff are required.

  3. The Symbol Digit Modalities Test as sentinel test for cognitive impairment in multiple sclerosis

    Van Schependom, J.; D'hooghe, M. B.; Cleynhens, K.; D'hooge, M.; Haelewyck, M. C.; De Keyser, J.; Nagels, G.

    Background and purpose: Cognitive impairment (CI) is found in about half of the multiple sclerosis (MS) population and is an important contributor to employment status and social functioning. CI is encountered in all disease stages and correlates only moderately with disease duration or Expanded

  4. From One to Multiple Accents on a Test of L2 Listening Comprehension

    Ockey, Gary J.; French, Robert

    2016-01-01

    Concerns about the need for assessing multidialectal listening skills for global contexts are becoming increasingly prevalent. However, the inclusion of multiple accents on listening assessments may threaten test fairness because it is not practical to include every accent that may be encountered in the language use domain on these tests. Given…

  5. Multiple-Choice versus Constructed-Response Tests in the Assessment of Mathematics Computation Skills.

    Gadalla, Tahany M.

    The equivalence of multiple-choice (MC) and constructed response (discrete) (CR-D) response formats as applied to mathematics computation at grade levels two to six was tested. The difference between total scores from the two response formats was tested for statistical significance, and the factor structure of items in both response formats was…

  6. A Particle Swarm Optimization Approach to Composing Serial Test Sheets for Multiple Assessment Criteria

    Yin, Peng-Yeng; Chang, Kuang-Cheng; Hwang, Gwo-Jen; Hwang, Gwo-Haur; Chan, Ying

    2006-01-01

    To accurately analyze the problems of students in learning, the composed test sheets must meet multiple assessment criteria, such as the ratio of relevant concepts to be evaluated, the average discrimination degree, difficulty degree and estimated testing time. Furthermore, to precisely evaluate the improvement of student's learning performance…

  7. Sample Size Calculation for Estimating or Testing a Nonzero Squared Multiple Correlation Coefficient

    Krishnamoorthy, K.; Xia, Yanping

    2008-01-01

    The problems of hypothesis testing and interval estimation of the squared multiple correlation coefficient of a multivariate normal distribution are considered. It is shown that available one-sided tests are uniformly most powerful, and the one-sided confidence intervals are uniformly most accurate. An exact method of calculating sample size to…

  8. Neutralizer Hollow Cathode Simulations and Comparisons with Ground Test Data

    Mikellides, Ioannis G.; Snyder, John S.; Goebel, Dan M.; Katz, Ira; Herman, Daniel A.

    2009-01-01

    The fidelity of electric propulsion physics-based models depends largely on the validity of their predictions over a range of operating conditions and geometries. In general, increased complexity of the physics requires more extensive comparisons with laboratory data to identify the region(s) that lie outside the validity of the model assumptions and to quantify the uncertainties within its range of application. This paper presents numerical simulations of neutralizer hollow cathodes at various operating conditions and orifice sizes. The simulations were performed using a two-dimensional axisymmetric model that solves numerically a relatively extensive system of conservation laws for the partially ionized gas in these devices. A summary of the comparisons between simulation results and Langmuir probe measurements is provided. The model has also been employed to provide insight into recent ground test observations of the neutralizer cathode in NEXT. It is found that a likely cause of the observed keeper voltage drop is cathode orifice erosion. However, due to the small magnitude of this change, is approx. 0.5 V (less than 5% of the beginning-of-life value) over 10 khrs, and in light of the large uncertainties of the cathode material sputtering yield at low ion energies, other causes cannot be excluded. Preliminary simulations to understand transition to plume mode suggest that in the range of 3-5 sccm the existing 2-D model reproduces fairly well the rise of the keeper voltage in the NEXT neutralizer as observed in the laboratory. At lower flow rates the simulation produces oscillations in the keeper current and voltage that require prohibitively small time-steps to resolve with the existing algorithms.

  9. Reanalysis comparisons of upper tropospheric-lower stratospheric jets and multiple tropopauses

    Manney, Gloria L.; Hegglin, Michaela I.; Lawrence, Zachary D.; Wargan, Krzysztof; Millán, Luis F.; Schwartz, Michael J.; Santee, Michelle L.; Lambert, Alyn; Pawson, Steven; Knosp, Brian W.; Fuller, Ryan A.; Daffer, William H.

    2017-09-01

    The representation of upper tropospheric-lower stratospheric (UTLS) jet and tropopause characteristics is compared in five modern high-resolution reanalyses for 1980 through 2014. Climatologies of upper tropospheric jet, subvortex jet (the lowermost part of the stratospheric vortex), and multiple tropopause frequency distributions in MERRA (Modern-Era Retrospective analysis for Research and Applications), ERA-I (ERA-Interim; the European Centre for Medium-Range Weather Forecasts, ECMWF, interim reanalysis), JRA-55 (the Japanese 55-year Reanalysis), and CFSR (the Climate Forecast System Reanalysis) are compared with those in MERRA-2. Differences between alternate products from individual reanalysis systems are assessed; in particular, a comparison of CFSR data on model and pressure levels highlights the importance of vertical grid spacing. Most of the differences in distributions of UTLS jets and multiple tropopauses are consistent with the differences in assimilation model grids and resolution - for example, ERA-I (with coarsest native horizontal resolution) typically shows a significant low bias in upper tropospheric jets with respect to MERRA-2, and JRA-55 (the Japanese 55-year Reanalysis) a more modest one, while CFSR (with finest native horizontal resolution) shows a high bias with respect to MERRA-2 in both upper tropospheric jets and multiple tropopauses. Vertical temperature structure and grid spacing are especially important for multiple tropopause characterizations. Substantial differences between MERRA and MERRA-2 are seen in mid- to high-latitude Southern Hemisphere (SH) winter upper tropospheric jets and multiple tropopauses as well as in the upper tropospheric jets associated with tropical circulations during the solstice seasons; some of the largest differences from the other reanalyses are seen in the same times and places. Very good qualitative agreement among the reanalyses is seen between the large-scale climatological features in UTLS jet and

  10. Test Results and Comparison of Triaxial Strength Testing of Waste Isolation Pilot Plant Clean Salt

    Buchholz, Stuart A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-12-01

    This memorandum documents laboratory thermomechanical triaxial strength testing of Waste Isolation Pilot Plant (WIPP) clean salt. The limited study completed independent, adjunct laboratory tests in the United States to assist in validating similar testing results being provided by the German facilities. The testing protocol consisted of completing confined triaxial, constant strain rate strength tests of intact WIPP clean salt at temperatures of 25°C and 100°C and at multiple confining pressures. The stratigraphy at WIPP also includes salt that has been labeled “argillaceous.” The much larger test matrix conducted in Germany included both the so-called clean and argillaceous salts. When combined, the total database of laboratory results will be used to develop input parameters for models, assess adequacy of existing models, and predict material behavior. These laboratory studies are also consistent with the goals of the international salt repository research program. The goal of this study was to complete a subset of a test matrix on clean salt from the WIPP undertaken by German research groups. The work was performed at RESPEC in Rapid City, South Dakota. A rigorous Quality Assurance protocol was applied, such that corroboration provides the potential of qualifying all of the test data gathered by German research groups.

  11. An open-source software program for performing Bonferroni and related corrections for multiple comparisons

    Kyle Lesack

    2011-01-01

    Full Text Available Increased type I error resulting from multiple statistical comparisons remains a common problem in the scientific literature. This may result in the reporting and promulgation of spurious findings. One approach to this problem is to correct groups of P-values for "family-wide significance" using a Bonferroni correction or the less conservative Bonferroni-Holm correction or to correct for the "false discovery rate" with a Benjamini-Hochberg correction. Although several solutions are available for performing this correction through commercially available software there are no widely available easy to use open source programs to perform these calculations. In this paper we present an open source program written in Python 3.2 that performs calculations for standard Bonferroni, Bonferroni-Holm and Benjamini-Hochberg corrections.

  12. Impact of Answer-Switching Behavior on Multiple-Choice Test Scores in Higher Education

    Ramazan BAŞTÜRK

    2011-06-01

    Full Text Available The multiple- choice format is one of the most popular selected-response item formats used in educational testing. Researchers have shown that Multiple-choice type test is a useful vehicle for student assessment in core university subjects that usually have large student numbers. Even though the educators, test experts and different test recourses maintain the idea that the first answer should be retained, many researchers argued that this argument is not dependent with empirical findings. The main question of this study is to examine how the answer switching behavior affects the multiple-choice test score. Additionally, gender differences and relationship between number of answer switching behavior and item parameters (item difficulty and item discrimination were investigated. The participants in this study consisted of 207 upper-level College of Education students from mid-sized universities. A Midterm exam consisted of 20 multiple-choice questions was used. According to the result of this study, answer switching behavior statistically increase test scores. On the other hand, there is no significant gender difference in answer-switching behavior. Additionally, there is a significant negative relationship between answer switching behavior and item difficulties.

  13. The Contribution of Numerical Magnitude Comparison and Phonological Processing to Individual Differences in Fourth Graders' Multiplication Fact Ability.

    Tamara M J Schleepen

    Full Text Available Although numerical magnitude processing has been related to individual differences in arithmetic, its role in children's multiplication performance remains largely unknown. On the other hand, studies have indicated that phonological awareness is an important correlate of individual differences in children's multiplication performance, but the involvement of phonological memory, another important phonological processing skill, has not been studied in much detail. Furthermore, knowledge about the relative contribution of above mentioned processes to the specific arithmetic operation of multiplication in children is lacking. The present study therefore investigated for the first time the unique contributions of numerical magnitude comparison and phonological processing in explaining individual differences in 63 fourth graders' multiplication fact ability (mean age = 9.6 years, SD = .67. The results showed that children's multiplication fact competency correlated significantly with symbolic and nonsymbolic magnitude comparison as well as with phonological short-term memory. A hierarchical regression analysis revealed that, after controlling for intellectual ability and general reaction time, both symbolic and nonsymbolic magnitude comparison and phonological short-term memory accounted for unique variance in multiplication fact performance. The ability to compare symbolic magnitudes was found to contribute the most, indicating that the access to numerical magnitudes by means of Arabic digits is a key factor in explaining individual differences in children's multiplication fact ability.

  14. A P-value model for theoretical power analysis and its applications in multiple testing procedures

    Fengqing Zhang

    2016-10-01

    Full Text Available Abstract Background Power analysis is a critical aspect of the design of experiments to detect an effect of a given size. When multiple hypotheses are tested simultaneously, multiplicity adjustments to p-values should be taken into account in power analysis. There are a limited number of studies on power analysis in multiple testing procedures. For some methods, the theoretical analysis is difficult and extensive numerical simulations are often needed, while other methods oversimplify the information under the alternative hypothesis. To this end, this paper aims to develop a new statistical model for power analysis in multiple testing procedures. Methods We propose a step-function-based p-value model under the alternative hypothesis, which is simple enough to perform power analysis without simulations, but not too simple to lose the information from the alternative hypothesis. The first step is to transform distributions of different test statistics (e.g., t, chi-square or F to distributions of corresponding p-values. We then use a step function to approximate each of the p-value’s distributions by matching the mean and variance. Lastly, the step-function-based p-value model can be used for theoretical power analysis. Results The proposed model is applied to problems in multiple testing procedures. We first show how the most powerful critical constants can be chosen using the step-function-based p-value model. Our model is then applied to the field of multiple testing procedures to explain the assumption of monotonicity of the critical constants. Lastly, we apply our model to a behavioral weight loss and maintenance study to select the optimal critical constants. Conclusions The proposed model is easy to implement and preserves the information from the alternative hypothesis.

  15. Pool swell sub-scale testing and code comparison

    Elisson, K.

    1981-01-01

    The main objective of the experiment was to investigate the pool swell dynamics in general and the forces on the lowered central part of the diaphragm between drywell and wetwell in particular. Apart from the high speed camera pressure transducers and strain gauges were used to monitor the transient. Data was recorded on a 14 channel FM recorder and then digitalised and plotted. In total more than one hundred tests were performed including parametric variations of for example geometry, break flow, initial drywell pressure and initial water level. In parallel to this experiment pool swell calculations have been performed with the computer codes COPTA and STEALTH. COPTA which is a lumped mass code for pressure suppression containment analysis has a slug pool swell mode. STEALTH which is a general purpose lagrangian hydrodynamics code has been used in a 2-D axisymmetric version. The STEALTH code has been used to calculate the radial variations in the vertical displacement and velocity of the pool surface and to predict the load on the lowered central part of the diaphragm. A comparison between the calculations and the experimental data indicates that both codes are sufficiently correct in their description of the pool swell transient. (orig.)

  16. IMRT commissioning: Multiple institution planning and dosimetry comparisons, a report from AAPM Task Group 119

    Ezzell, Gary A.; Burmeister, Jay W.; Dogan, Nesrin [Department of Radiation Oncology, Mayo Clinic Scottsdale, 5777 East Mayo Boulevard, MCSB Concourse, Phoenix, Arizona 89054 (United States); and others

    2009-11-15

    AAPM Task Group 119 has produced quantitative confidence limits as baseline expectation values for IMRT commissioning. A set of test cases was developed to assess the overall accuracy of planning and delivery of IMRT treatments. Each test uses contours of targets and avoidance structures drawn within rectangular phantoms. These tests were planned, delivered, measured, and analyzed by nine facilities using a variety of IMRT planning and delivery systems. Each facility had passed the Radiological Physics Center credentialing tests for IMRT. The agreement between the planned and measured doses was determined using ion chamber dosimetry in high and low dose regions, film dosimetry on coronal planes in the phantom with all fields delivered, and planar dosimetry for each field measured perpendicular to the central axis. The planar dose distributions were assessed using gamma criteria of 3%/3 mm. The mean values and standard deviations were used to develop confidence limits for the test results using the concept confidence limit=|mean|+1.96{sigma}. Other facilities can use the test protocol and results as a basis for comparison to this group. Locally derived confidence limits that substantially exceed these baseline values may indicate the need for improved IMRT commissioning.

  17. Testing a multiple mediation model of Asian American college students' willingness to see a counselor.

    Kim, Paul Youngbin; Park, Irene J K

    2009-07-01

    Adapting the theory of reasoned action, the present study examined help-seeking beliefs, attitudes, and intent among Asian American college students (N = 110). A multiple mediation model was tested to see if the relation between Asian values and willingness to see a counselor was mediated by attitudes toward seeking professional psychological help and subjective norm. A bootstrapping procedure was used to test the multiple mediation model. Results indicated that subjective norm was the sole significant mediator of the effect of Asian values on willingness to see a counselor. The findings highlight the importance of social influences on help-seeking intent among Asian American college students.

  18. Comparison between Two Assessment Methods; Modified Essay Questions and Multiple Choice Questions

    Assadi S.N.* MD

    2015-09-01

    Full Text Available Aims Using the best assessment methods is an important factor in educational development of health students. Modified essay questions and multiple choice questions are two prevalent methods of assessing the students. The aim of this study was to compare two methods of modified essay questions and multiple choice questions in occupational health engineering and work laws courses. Materials & Methods This semi-experimental study was performed during 2013 to 2014 on occupational health students of Mashhad University of Medical Sciences. The class of occupational health and work laws course in 2013 was considered as group A and the class of 2014 as group B. Each group had 50 students.The group A students were assessed by modified essay questions method and the group B by multiple choice questions method.Data were analyzed in SPSS 16 software by paired T test and odd’s ratio. Findings The mean grade of occupational health and work laws course was 18.68±0.91 in group A (modified essay questions and was 18.78±0.86 in group B (multiple choice questions which was not significantly different (t=-0.41; p=0.684. The mean grade of chemical chapter (p<0.001 in occupational health engineering and harmful work law (p<0.001 and other (p=0.015 chapters in work laws were significantly different between two groups. Conclusion Modified essay questions and multiple choice questions methods have nearly the same student assessing value for the occupational health engineering and work laws course.

  19. M-GCAT: interactively and efficiently constructing large-scale multiple genome comparison frameworks in closely related species

    Messeguer Xavier

    2006-10-01

    Full Text Available Abstract Background Due to recent advances in whole genome shotgun sequencing and assembly technologies, the financial cost of decoding an organism's DNA has been drastically reduced, resulting in a recent explosion of genomic sequencing projects. This increase in related genomic data will allow for in depth studies of evolution in closely related species through multiple whole genome comparisons. Results To facilitate such comparisons, we present an interactive multiple genome comparison and alignment tool, M-GCAT, that can efficiently construct multiple genome comparison frameworks in closely related species. M-GCAT is able to compare and identify highly conserved regions in up to 20 closely related bacterial species in minutes on a standard computer, and as many as 90 (containing 75 cloned genomes from a set of 15 published enterobacterial genomes in an hour. M-GCAT also incorporates a novel comparative genomics data visualization interface allowing the user to globally and locally examine and inspect the conserved regions and gene annotations. Conclusion M-GCAT is an interactive comparative genomics tool well suited for quickly generating multiple genome comparisons frameworks and alignments among closely related species. M-GCAT is freely available for download for academic and non-commercial use at: http://alggen.lsi.upc.es/recerca/align/mgcat/intro-mgcat.html.

  20. Test of Understanding of Vectors: A Reliable Multiple-Choice Vector Concept Test

    Barniol, Pablo; Zavala, Genaro

    2014-01-01

    In this article we discuss the findings of our research on students' understanding of vector concepts in problems without physical context. First, we develop a complete taxonomy of the most frequent errors made by university students when learning vector concepts. This study is based on the results of several test administrations of open-ended…

  1. Stochastic order in dichotomous item response models for fixed tests, research adaptive tests, or multiple abilities

    van der Linden, Willem J.

    1995-01-01

    Dichotomous item response theory (IRT) models can be viewed as families of stochastically ordered distributions of responses to test items. This paper explores several properties of such distributiom. The focus is on the conditions under which stochastic order in families of conditional

  2. Comparison between cerebral ischemia disease and multiple sclerosis by using MR diffusion tensor imaging

    Lou Xin; Cai Youquan; Ma Lin; Cai Jianming

    2007-01-01

    Objective: To assess the value of MR diffusion tensor imaging (DTI) in the differentiation between the patients with cerebral ischemia disease and multiple sclerosis. Methods: MR diffusion tensor imaging was performed in thirty-two patients with internal carotid artery stenosis ≥70% and eighteen patients with clinical diagnosed multiple sclerosis. Fractional anisotropy (FA) value of the germ, splenium, body of the corpus callosum, and the white matter of the frontal and occipital lobe were measured respectively, and independent-sample t-test statistical analysis was performed. Results: The FA value was decreased obviously in the anterior and posterior body and splenium of the corpus callosumin the MS patients compared with the ICA severe stenosis patients (0.67 ± 0.12 vs. 0.75 ± 0.05, t=3.443, P 0.05; 0.34 ± 0.08 vs. 0.34 ± 0.05, t=0.137, P> 0.05; 0.29 ± 0.06 vs. 0.40 ± 0.06, t=5.449, P>0.05). Conclusion: DTI can noninvasive detect the potential disorder of corpus callosum in vivo, thus providing useful information to differentiate the cerebral ischemia disease from multiple sclerosis. (authors)

  3. Comparison of PSF maxima and minima of multiple annuli coded aperture (MACA) and complementary multiple annuli coded aperture (CMACA) systems

    Ratnam, Challa; Lakshmana Rao, Vadlamudi; Lachaa Goud, Sivagouni

    2006-10-01

    In the present paper, and a series of papers to follow, the Fourier analytical properties of multiple annuli coded aperture (MACA) and complementary multiple annuli coded aperture (CMACA) systems are investigated. First, the transmission function for MACA and CMACA is derived using Fourier methods and, based on the Fresnel-Kirchoff diffraction theory, the formulae for the point spread function are formulated. The PSF maxima and minima are calculated for both the MACA and CMACA systems. The dependence of these properties on the number of zones is studied and reported in this paper.

  4. Comparison of PSF maxima and minima of multiple annuli coded aperture (MACA) and complementary multiple annuli coded aperture (CMACA) systems

    Ratnam, Challa; Rao, Vadlamudi Lakshmana; Goud, Sivagouni Lachaa

    2006-01-01

    In the present paper, and a series of papers to follow, the Fourier analytical properties of multiple annuli coded aperture (MACA) and complementary multiple annuli coded aperture (CMACA) systems are investigated. First, the transmission function for MACA and CMACA is derived using Fourier methods and, based on the Fresnel-Kirchoff diffraction theory, the formulae for the point spread function are formulated. The PSF maxima and minima are calculated for both the MACA and CMACA systems. The dependence of these properties on the number of zones is studied and reported in this paper

  5. The "None of the Above" Option in Multiple-Choice Testing: An Experimental Study

    DiBattista, David; Sinnige-Egger, Jo-Anne; Fortuna, Glenda

    2014-01-01

    The authors assessed the effects of using "none of the above" as an option in a 40-item, general-knowledge multiple-choice test administered to undergraduate students. Examinees who selected "none of the above" were given an incentive to write the correct answer to the question posed. Using "none of the above" as the…

  6. The guinea pig maximization test--with a multiple dose design

    Andersen, Klaus Ejner; Vølund, A; Frankild, S

    1995-01-01

    The guinea pig maximization test (GPMT) is usually performed with one moderately irritant induction dose of the allergen and gives a qualitative assessment-hazard identification-of the allergenicity of the chemical. We refined the GPMT by applying a multiple dose design and used 30 guinea pigs in...

  7. Performance on Paced Auditory Serial Addition Test and cerebral blood flow in multiple sclerosis

    D'haeseleer, M.; Steen, C.; Hoogduin, J. M.; van Osch, M. J. P.; Fierens, Y.; Cambron, M.; Koch, M. W.; De Keyser, J.

    BackgroundTo assess the relationship between performance on the Paced Auditory Serial Addition Test (PASAT) and both cerebral blood flow (CBF) and axonal metabolic integrity in normal appearing white matter (NAWM) of the centrum semiovale in patients with multiple sclerosis (MS). MethodsNormal

  8. Application of range-test in multiple linear regression analysis in ...

    Application of range-test in multiple linear regression analysis in the presence of outliers is studied in this paper. First, the plot of the explanatory variables (i.e. Administration, Social/Commercial, Economic services and Transfer) on the dependent variable (i.e. GDP) was done to identify the statistical trend over the years.

  9. Constructing a multiple choice test to measure elementary school teachers' Pedagogical Content Knowledge of technology education.

    Rohaan, E.J.; Taconis, R.; Jochems, W.M.G.

    2009-01-01

    This paper describes the construction and validation of a multiple choice test to measure elementary school teachers' Pedagogical Content Knowledge of technology education. Pedagogical Content Knowledge is generally accepted to be a crucial domain of teacher knowledge and is, therefore, an important

  10. Testing Mediation Using Multiple Regression and Structural Equation Modeling Analyses in Secondary Data

    Li, Spencer D.

    2011-01-01

    Mediation analysis in child and adolescent development research is possible using large secondary data sets. This article provides an overview of two statistical methods commonly used to test mediated effects in secondary analysis: multiple regression and structural equation modeling (SEM). Two empirical studies are presented to illustrate the…

  11. The guinea pig maximization test--with a multiple dose design

    Andersen, Klaus Ejner; Vølund, A; Frankild, S

    1995-01-01

    The guinea pig maximization test (GPMT) is usually performed with one moderately irritant induction dose of the allergen and gives a qualitative assessment-hazard identification-of the allergenicity of the chemical. We refined the GPMT by applying a multiple dose design and used 30 guinea pigs...

  12. A multiple treatment comparison meta-analysis of monoamine oxidase type B inhibitors for Parkinson's disease.

    Binde, C D; Tvete, I F; Gåsemyr, J; Natvig, B; Klemp, M

    2018-05-30

    To the best of our knowledge, there are no systematic reviews or meta-analyses that compare rasagiline, selegiline and safinamide. Therefore, we aimed to perform a drug class review comparing all available monoamine oxidase type B (MAO-B) inhibitors in a multiple treatment comparison. We performed a systematic literature search to identify randomized controlled trials assessing the efficacy of MAO-B inhibitors in patients with Parkinson's disease. MAO-B inhibitors were evaluated either as monotherapy or in combination with levodopa or dopamine agonists. Endpoints of interest were change in the Unified Parkinson's Disease Rating Scale (UPDRS) score and serious adverse events. We estimated the relative effect of each MAO-B inhibitor versus the comparator drug by creating three networks of direct and indirect comparisons. For each of the networks, we considered a joint model. The systematic literature search and study selection process identified 27 publications eligible for our three network analyses. We found the relative effects of rasagiline, safinamide and selegiline treatment given alone and compared to placebo in a model without explanatory variables to be 1.560 (1.409, 1.734), 1.449 (0.873, 2.413) and 1.532 (1.337, 1.757) respectively. We also found all MAO-B inhibitors to be efficient when given together with levodopa. When ranking the MAO-B inhibitors given in combination with levodopa, selegiline was the most effective and rasagiline was the second best. All of the included MAO-B inhibitors were effective compared to placebo when given as monotherapy. Combination therapy with MAO-B inhibitors and levodopa showed that all three MAO-B inhibitors were effective compared to placebo, but selegiline was the most effective drug. © 2018 The British Pharmacological Society.

  13. Comparison of different cryogenic control strategies via simulation applied to a superconducting magnet test bench at CERN

    Arpaia, P.; Coppier, H.; De Paola, D.; di Bernardo, M.; Guarino, A.; Pedemonte, B. Luz; Pezzetti, M.

    2017-12-01

    Industrial process controllers for cryogenic systems used in test facilities for superconducting magnets are typically PIDs, tuned by operational expertise according to users’ requirements (covering cryogenic transients and associated thermo-mechanical constraints). In this paper, an alternative fully-automatic solution, equally based on PID controllers, is proposed. Following the comparison of the operational expertise and alternative fully-automatic approaches, a new process control configuration, based on an estimated multiple-input/multiple-output (MIMO) model is proposed. The new MIMO model-based approach fulfils the required operational constraints while improving performance compared to existing solutions. The analysis and design work is carried out using both theoretical and numerical tools and is validated on the case study of the High Field Magnet (HFM) cryogenic test bench running at the SM18 test facility located at CERN. The proposed solution have been validated by simulation using the CERN ECOSIMPRO software tools using the cryogenic library (CRYOLIB [1]) developed at CERN.

  14. A Comparison of Combustion Dynamics for Multiple 7-Point Lean Direct Injection Combustor Configurations

    Tacina, K. M.; Hicks, Y. R.

    2017-01-01

    The combustion dynamics of multiple 7-point lean direct injection (LDI) combustor configurations are compared. LDI is a fuel-lean combustor concept for aero gas turbine engines in which multiple small fuel-air mixers replace one traditionally-sized fuel-air mixer. This 7-point LDI configuration has a circular cross section, with a center (pilot) fuel-air mixer surrounded by six outer (main) fuel-air mixers. Each fuel-air mixer consists of an axial air swirler followed by a converging-diverging venturi. A simplex fuel injector is inserted through the center of the air swirler, with the fuel injector tip located near the venturi throat. All 7 fuel-air mixers are identical except for the swirler blade angle, which varies with the configuration. Testing was done in a 5-atm flame tube with inlet air temperatures from 600 to 800 F and equivalence ratios from 0.4 to 0.7. Combustion dynamics were measured using a cooled PCB pressure transducer flush-mounted in the wall of the combustor test section.

  15. Multiple linear combination (MLC) regression tests for common variants adapted to linkage disequilibrium structure.

    Yoo, Yun Joo; Sun, Lei; Poirier, Julia G; Paterson, Andrew D; Bull, Shelley B

    2017-02-01

    By jointly analyzing multiple variants within a gene, instead of one at a time, gene-based multiple regression can improve power, robustness, and interpretation in genetic association analysis. We investigate multiple linear combination (MLC) test statistics for analysis of common variants under realistic trait models with linkage disequilibrium (LD) based on HapMap Asian haplotypes. MLC is a directional test that exploits LD structure in a gene to construct clusters of closely correlated variants recoded such that the majority of pairwise correlations are positive. It combines variant effects within the same cluster linearly, and aggregates cluster-specific effects in a quadratic sum of squares and cross-products, producing a test statistic with reduced degrees of freedom (df) equal to the number of clusters. By simulation studies of 1000 genes from across the genome, we demonstrate that MLC is a well-powered and robust choice among existing methods across a broad range of gene structures. Compared to minimum P-value, variance-component, and principal-component methods, the mean power of MLC is never much lower than that of other methods, and can be higher, particularly with multiple causal variants. Moreover, the variation in gene-specific MLC test size and power across 1000 genes is less than that of other methods, suggesting it is a complementary approach for discovery in genome-wide analysis. The cluster construction of the MLC test statistics helps reveal within-gene LD structure, allowing interpretation of clustered variants as haplotypic effects, while multiple regression helps to distinguish direct and indirect associations. © 2016 The Authors Genetic Epidemiology Published by Wiley Periodicals, Inc.

  16. Comparison of stress in single and multiple layer depositions of plasma-deposited amorphous silicon dioxide

    Au, V; Charles, C; Boswell, R W

    2006-01-01

    The stress in a single-layer continuous deposition of amorphous silicon dioxide (SiO 2 ) film is compared with the stress within multiple-layer intermittent or 'stop-start' depositions. The films were deposited by helicon activated reactive evaporation (plasma assisted deposition with electron beam evaporation source) to a 1 μm total film thickness. The relationships for stress as a function of film thickness for single, two, four and eight layer depositions have been obtained by employing the substrate curvature technique on a post-deposition etch-back of the SiO 2 film. At film thicknesses of less than 300 nm, the stress-thickness relationships clearly show an increase in stress in the multiple-layer samples compared with the relationship for the single-layer film. By comparison, there is little variation in the film stress between the samples when it is measured at 1 μm film thickness. Localized variations in stress were not observed in the regions where the 'stop-start' depositions occurred. The experimental results are interpreted as a possible indication of the presence of unstable, strained Si-O-Si bonds in the amorphous SiO 2 film. It is proposed that the subsequent introduction of a 'stop-start' deposition process places additional strain on these bonds to affect the film structure. The experimental stress-thickness relationships were reproduced independently by assuming a linear relationship between the measured bow and film thickness. The constants of the linear model are interpreted as an indication of the density of the amorphous film structure

  17. Social Comparison, Multiple Reference Groups, and the Self-Concepts of Academically Handicapped Children Before and After Mainstreaming.

    Strang, Louise; And Others

    1978-01-01

    Predictions from social comparison theory and group reference theory were tested in two experiments assessing the impact of half-day mainstreaming upon the self-concepts of academically handicapped children. The results supported the theoretical viability of social comparison theory and group reference theory in educational settings. (Author/BH)

  18. Allergy tests: Comparison between the Radio-Allergo-Sorbent Test (RAST) and cutaneous test as well as inhalative provocation test

    Langenstrass, J.A.

    1979-01-01

    As this publication has shown, the Radio-Allergo-Sorbent Test (RAST) is well suited for investigation programs. Absence of physical strain for the patient, precise reproducibility of the results and fair agreement with other test methods are above all qualities in favour of RAST. Its main disadvantages are the as yet rather restricted spectrum of allergens and expensiveness and high technical requirement. Substantial technical requirements are also involved with the inhalative provocation test, if properly carried out, but here the spectrum of allergens is by far greater. On the other hand, it exposes patients to great physical strain. The skin tests are most simple to carry out but present the largest position of misresults and are less reproducible than the two former procedures. The Radio-Immuno-Sorbent Test (RIST) can provide very useful results as a preliminary test but is also very costly owing to its high technical demands. - In conclusion, RAST is most conveniently used as a co-test in a complete investigation program where it constitutes a valuable aid. As a sole alternative to skin tests and inhalative provocation tests it is a yet not recommendable for the above-mentioned reasons. Although not able to replace the two conventional methods within the foreseeable future, it is expected to be used more widely on further development. (orig./MG) [de

  19. Comparison of charged particle multiplicity distributions in p tilde p and pp interactions and verification of the dual unitarization scheme

    Batyunya, B.V.; Boguslavsky, I.V.; Gramenitsky, I.M.

    1979-01-01

    The difference between antiproton annihilation and pp interactions has been discussed. Charged particle multiplicity distributions in anti pp-interactions at 22.4 GeV/c were used to obtain antiproton annihilation characteristics. The comparison of the topological cross section of antipp interactions with those of non-diffractive pp interactions confirms the validity of dual unitarization

  20. Resampling-based methods in single and multiple testing for equality of covariance/correlation matrices.

    Yang, Yang; DeGruttola, Victor

    2012-06-22

    Traditional resampling-based tests for homogeneity in covariance matrices across multiple groups resample residuals, that is, data centered by group means. These residuals do not share the same second moments when the null hypothesis is false, which makes them difficult to use in the setting of multiple testing. An alternative approach is to resample standardized residuals, data centered by group sample means and standardized by group sample covariance matrices. This approach, however, has been observed to inflate type I error when sample size is small or data are generated from heavy-tailed distributions. We propose to improve this approach by using robust estimation for the first and second moments. We discuss two statistics: the Bartlett statistic and a statistic based on eigen-decomposition of sample covariance matrices. Both statistics can be expressed in terms of standardized errors under the null hypothesis. These methods are extended to test homogeneity in correlation matrices. Using simulation studies, we demonstrate that the robust resampling approach provides comparable or superior performance, relative to traditional approaches, for single testing and reasonable performance for multiple testing. The proposed methods are applied to data collected in an HIV vaccine trial to investigate possible determinants, including vaccine status, vaccine-induced immune response level and viral genotype, of unusual correlation pattern between HIV viral load and CD4 count in newly infected patients.

  1. PCA-based bootstrap confidence interval tests for gene-disease association involving multiple SNPs

    Xue Fuzhong

    2010-01-01

    Full Text Available Abstract Background Genetic association study is currently the primary vehicle for identification and characterization of disease-predisposing variant(s which usually involves multiple single-nucleotide polymorphisms (SNPs available. However, SNP-wise association tests raise concerns over multiple testing. Haplotype-based methods have the advantage of being able to account for correlations between neighbouring SNPs, yet assuming Hardy-Weinberg equilibrium (HWE and potentially large number degrees of freedom can harm its statistical power and robustness. Approaches based on principal component analysis (PCA are preferable in this regard but their performance varies with methods of extracting principal components (PCs. Results PCA-based bootstrap confidence interval test (PCA-BCIT, which directly uses the PC scores to assess gene-disease association, was developed and evaluated for three ways of extracting PCs, i.e., cases only(CAES, controls only(COES and cases and controls combined(CES. Extraction of PCs with COES is preferred to that with CAES and CES. Performance of the test was examined via simulations as well as analyses on data of rheumatoid arthritis and heroin addiction, which maintains nominal level under null hypothesis and showed comparable performance with permutation test. Conclusions PCA-BCIT is a valid and powerful method for assessing gene-disease association involving multiple SNPs.

  2. Design and performance of beam test electronics for the PHENIX multiplicity vertex detector

    Britton, C.L. Jr.; Bryan, W.L.; Emery, M.S.

    1996-01-01

    The system architecture and test results of the custom circuits and beam test system for the Multiplicity-Vertex Detector (MVD) for the PHENIX detector collaboration at the Relativistic Heavy Ion Collider (RHIC) are presented in this paper. The final detector per-channel signal processing chain will consist of a preamplifier-gain stage, a current-mode summed multiplicity discriminator, a 64-deep analog memory (simultaneous read-write), a post-memory analog correlator, and a 10-bit 5 μs ADC. The Heap Manager provides all timing control, data buffering, and data formatting for a single 256-channel multi-chip module (MCM). Each chip set is partitioned into 32-channel sets. Beam test (16-cell deep memory) performance for the various blocks will be presented as well as the ionizing radiation damage performance of the 1.2 μ n-well CMOS process used for preamplifier fabrication

  3. Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.

    Halfon, Philippe; Bacq, Yannick; De Muret, Anne; Penaranda, Guillaume; Bourliere, Marc; Ouzan, Denis; Tran, Albert; Botta, Danielle; Renou, Christophe; Bréchot, Marie-Claude; Degott, Claude; Paradis, Valérie

    2007-03-01

    We evaluated the test performance profile (TPP) of blood tests of liver fibrosis. Three hundred and fifty-six patients with C chronic hepatitis were included in two centers. Metavir staging of liver specimens by two independent pathologists and the following tests were evaluated: Fibrotest (FT), APRI, FibroMeter (FM), and Hepascore (HS). Metavir stages were: F0: 4%, F1: 55%, F2: 26%, F3: 11%, and F4: 4%. The AUROCs were not significantly different, respectively, FT, FM, APRI, HS: >or=F2: 0.79, 0.78, 0.76, >or=0.76; F3: 0.81, 0.85, 0.81, 0.81; and F4: 0.86, 0.94, 0.92, 0.89. The TPP relies on the paired comparison of blood-test misclassification based on liver specimen, e.g. FT vs FM, respectively: F0+1: 18 vs 28% (p=0.0003), >or=F2: 43 vs 31% (p=0.004). There was no center effect. In those populations, the four blood tests had a similar performance for significant fibrosis (F>or=2), lying in the lower range of published results which is attributable to a low >or=F2 prevalence, and for >or=F3 and F4. However, FM and FT had performance profiles significantly different as a function of fibrosis stages or diagnostic target (fibrosis cut-off). This has to be considered during the interpretation process. Moreover, the performance should be reported with different diagnostic targets.

  4. Autologous hematopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: comparison with secondary progressive multiple sclerosis.

    Casanova, Bonaventura; Jarque, Isidro; Gascón, Francisco; Hernández-Boluda, Juan Carlos; Pérez-Miralles, Francisco; de la Rubia, Javier; Alcalá, Carmen; Sanz, Jaime; Mallada, Javier; Cervelló, Angeles; Navarré, Arantxa; Carcelén-Gadea, María; Boscá, Isabel; Gil-Perotin, Sara; Solano, Carlos; Sanz, Miguel Angel; Coret, Francisco

    2017-07-01

    The main objective of our work is to describe the long-term results of myeloablative autologous hematopoietic stem cell transplant (AHSCT) in multiple sclerosis patients. Patients that failed to conventional therapies for multiple sclerosis (MS) underwent an approved protocol for AHSCT, which consisted of peripheral blood stem cell mobilization with cyclophosphamide and granulocyte colony-stimulating factor (G-CSF), followed by a conditioning regimen of BCNU, Etoposide, Ara-C, Melphalan IV, plus Rabbit Thymoglobulin. Thirty-eight MS patients have been transplanted since 1999. Thirty-one patients have been followed for more than 2 years (mean 8.4 years). There were 22 relapsing-remitting multiple sclerosis (RRMS) patients and 9 secondary progressive multiple sclerosis (SPMS) patients. No death related to AHSCT. A total of 10 patients (32.3%) had at least one relapse during post-AHSCT evolution, 6 patients in the RRMS group (27.2%) and 4 in the SPMS group (44.4%). After AHSCT, 7 patients (22.6%) experienced progression of disability, all within SP form. By contrast, no patients with RRMS experienced worsening of disability after a median follow-up of 5.4 years, 60% of them showed a sustained reduction in disability (SRD), defined as the improvement of 1.0 point in the expanded disability status scale (EDSS) sustains for 6 months (0.5 in cases of EDSS ≥ 5.5). The only clinical variable that predicted a poor response to AHSCT was a high EDSS in the year before transplant. AHSCT using the BEAM-ATG scheme is safe and efficacious to control the aggressive forms of RRMS.

  5. A permutation-based multiple testing method for time-course microarray experiments

    George Stephen L

    2009-10-01

    Full Text Available Abstract Background Time-course microarray experiments are widely used to study the temporal profiles of gene expression. Storey et al. (2005 developed a method for analyzing time-course microarray studies that can be applied to discovering genes whose expression trajectories change over time within a single biological group, or those that follow different time trajectories among multiple groups. They estimated the expression trajectories of each gene using natural cubic splines under the null (no time-course and alternative (time-course hypotheses, and used a goodness of fit test statistic to quantify the discrepancy. The null distribution of the statistic was approximated through a bootstrap method. Gene expression levels in microarray data are often complicatedly correlated. An accurate type I error control adjusting for multiple testing requires the joint null distribution of test statistics for a large number of genes. For this purpose, permutation methods have been widely used because of computational ease and their intuitive interpretation. Results In this paper, we propose a permutation-based multiple testing procedure based on the test statistic used by Storey et al. (2005. We also propose an efficient computation algorithm. Extensive simulations are conducted to investigate the performance of the permutation-based multiple testing procedure. The application of the proposed method is illustrated using the Caenorhabditis elegans dauer developmental data. Conclusion Our method is computationally efficient and applicable for identifying genes whose expression levels are time-dependent in a single biological group and for identifying the genes for which the time-profile depends on the group in a multi-group setting.

  6. Swimming with multiple propulsors: measurement and comparison of swimming gaits in three species of neotropical cichlids.

    Feilich, Kara L

    2017-11-15

    Comparative studies of fish swimming have been limited by the lack of quantitative definitions of fish gaits. Traditionally, steady swimming gaits have been defined categorically by the fin or region of the body that is used as the main propulsor and named after major fish clades (e.g. carangiform, anguilliform, balistiform, labriform). This method of categorization is limited by the lack of explicit measurements, the inability to incorporate contributions of multiple propulsors and the inability to compare gaits across different categories. I propose an alternative framework for the definition and comparison of fish gaits based on the propulsive contribution of each structure (body and/or fin) being used as a propulsor relative to locomotor output, and demonstrate the effectiveness of this framework by comparing three species of neotropical cichlids with different body shapes. This approach is modular with respect to the number of propulsors considered, flexible with respect to the definition of the propulsive inputs and the locomotor output of interest, and designed explicitly to handle combinations of propulsors. Using this approach, gait can be defined as a trajectory through propulsive space, and gait transitions can be defined as discontinuities in the gait trajectory. By measuring and defining gait in this way, patterns of clustering corresponding to existing categorical definitions of gait may emerge, and gaits can be rigorously compared across categories. © 2017. Published by The Company of Biologists Ltd.

  7. Estimates of statistical significance for comparison of individual positions in multiple sequence alignments

    Sadreyev Ruslan I

    2004-08-01

    Full Text Available Abstract Background Profile-based analysis of multiple sequence alignments (MSA allows for accurate comparison of protein families. Here, we address the problems of detecting statistically confident dissimilarities between (1 MSA position and a set of predicted residue frequencies, and (2 between two MSA positions. These problems are important for (i evaluation and optimization of methods predicting residue occurrence at protein positions; (ii detection of potentially misaligned regions in automatically produced alignments and their further refinement; and (iii detection of sites that determine functional or structural specificity in two related families. Results For problems (1 and (2, we propose analytical estimates of P-value and apply them to the detection of significant positional dissimilarities in various experimental situations. (a We compare structure-based predictions of residue propensities at a protein position to the actual residue frequencies in the MSA of homologs. (b We evaluate our method by the ability to detect erroneous position matches produced by an automatic sequence aligner. (c We compare MSA positions that correspond to residues aligned by automatic structure aligners. (d We compare MSA positions that are aligned by high-quality manual superposition of structures. Detected dissimilarities reveal shortcomings of the automatic methods for residue frequency prediction and alignment construction. For the high-quality structural alignments, the dissimilarities suggest sites of potential functional or structural importance. Conclusion The proposed computational method is of significant potential value for the analysis of protein families.

  8. On Thermally Interacting Multiple Boreholes with Variable Heating Strength: Comparison between Analytical and Numerical Approaches

    Marc A. Rosen

    2012-08-01

    Full Text Available The temperature response in the soil surrounding multiple boreholes is evaluated analytically and numerically. The assumption of constant heat flux along the borehole wall is examined by coupling the problem to the heat transfer problem inside the borehole and presenting a model with variable heat flux along the borehole length. In the analytical approach, a line source of heat with a finite length is used to model the conduction of heat in the soil surrounding the boreholes. In the numerical method, a finite volume method in a three dimensional meshed domain is used. In order to determine the heat flux boundary condition, the analytical quasi-three-dimensional solution to the heat transfer problem of the U-tube configuration inside the borehole is used. This solution takes into account the variation in heating strength along the borehole length due to the temperature variation of the fluid running in the U-tube. Thus, critical depths at which thermal interaction occurs can be determined. Finally, in order to examine the validity of the numerical method, a comparison is made with the results of line source method.

  9. Developing the multiple stress-strain creep recovery (MS-SCR) test

    Elnasri, Mahmoud; Airey, Gordon; Thom, Nick

    2018-04-01

    While most published work from Europe has been concerned with evaluating binders' resistance to rutting based on their stiffness (deformation resistance), work originating in the US has mainly been concerned with ranking binders based on their recoverability in a multiple stress form. This paper details the design of a new modified multiple stress-strain creep recovery (MS-SCR) test. The test is designed to evaluate binders' rutting resistance based on two rutting resistance mechanisms: stiffness and recoverability. A preliminary investigation is presented in this paper followed by details of the design of the new modified test. A 40/60 penetration grade bitumen and bitumen-filler mastics prepared with three filler concentrations (35%, 50%, and 65% filler content by mass of mastic) were tested. In addition, two polymer modified bitumens (PMBs) using the same base bitumen type were examined for validation. Two parameters are introduced to characterise the short and long recovery in the new test. In terms of stiffness, the test allows the behaviour of binders at different stress levels and loading cycles to be studied and produces a new parameter that can quantify the degree of modification. Finally, a relationship between nonlinearity and normal force in the test was investigated.

  10. Learners Test Performance and Gardner`s Multiple Inteligence Theory: Intercorrelation in a Bilingual Context

    Bagher Azarmi

    2015-03-01

    Full Text Available Although decisions and inferences made based on test scores depend both on the characteristics of test takers and testing environment, the former seems to have the most overridingimportance. The present study which was conducted in a bilingual environment is in line with this assumption and is aimed at investigating intelligence as one of the test taker characteristics. First, it aimed at finding the possible correlation between any of the eight types of intelligences in Gardner`s MI theory and EAP test performance. Second, it intended to survey the intercorrelationamong the eight types of intelligences themselves. To that end, 122 male bilingual EFL learners who were all sophomore university students were chosen as the participants of the study. They satfor the final EAP exam and filled the questionnaire on multiple intelligence. The test takers' scores on EAP exam were correlated with their multiple intelligences. The result did not demonstrate anystatistically significant go-togetherness between EAP test performance and any types of intelligence; however, a significantly positive correlation was observed among the eight types of intelligences themselves showing that all types of intelligences are equally important and ought to be equally dealt with in EFL context.

  11. Item difficulty of multiple choice tests dependant on different item response formats – An experiment in fundamental research on psychological assessment

    KLAUS D. KUBINGER

    2007-12-01

    Full Text Available Multiple choice response formats are problematical as an item is often scored as solved simply because the test-taker is a lucky guesser. Instead of applying pertinent IRT models which take guessing effects into account, a pragmatic approach of re-conceptualizing multiple choice response formats to reduce the chance of lucky guessing is considered. This paper compares the free response format with two different multiple choice formats. A common multiple choice format with a single correct response option and five distractors (“1 of 6” is used, as well as a multiple choice format with five response options, of which any number of the five is correct and the item is only scored as mastered if all the correct response options and none of the wrong ones are marked (“x of 5”. An experiment was designed, using pairs of items with exactly the same content but different response formats. 173 test-takers were randomly assigned to two test booklets of 150 items altogether. Rasch model analyses adduced a fitting item pool, after the deletion of 39 items. The resulting item difficulty parameters were used for the comparison of the different formats. The multiple choice format “1 of 6” differs significantly from “x of 5”, with a relative effect of 1.63, while the multiple choice format “x of 5” does not significantly differ from the free response format. Therefore, the lower degree of difficulty of items with the “1 of 6” multiple choice format is an indicator of relevant guessing effects. In contrast the “x of 5” multiple choice format can be seen as an appropriate substitute for free response format.

  12. Reliability of Autonomic Responses and Malaise Across Multiple Motion Sickness Stimulation Tests

    Stout, Cynthia S.; Toscano, William B.; Cowings, Patricia S.

    1993-01-01

    There is general agreement that a high degree of variability exists between subjects in their autonomic nervous system responses to motion sickness stimulation. Additionally, a paucity of data exists that examines the variability within an individual across repeated motion sickness tests. Investigators have also examined the relationship of autonomic responses to motion sickness development. These investigations have used analyses at discrete points in time to describe this relationship. This approach fails to address the time course of autonomic responses and malaise development throughout the motion sickness test. Our objectives were to examine the reliability of autonomic responses and malaise using the final minute of the motion sickness test across five testing occasions, to examine the reliability of the change in autonomic responses and the change in malaise across five testing occasions, and to examine the relationship between changes in autonomic responses and changes in malaise level across the entire motion sickness test. Our results indicate that, based on the final minute of testing, the autonomic responses of heart rate, blood volume pulse, and respiration rate are moderately stable across multiple tests. Changes in heart rate, blood volume pulse, respiration rate, and malaise throughout the test duration were less stable across the tests. We attribute this instability to variations in individual susceptibility and the error associated with estimating a measure of autonomic gain.

  13. Robust inference from multiple test statistics via permutations: a better alternative to the single test statistic approach for randomized trials.

    Ganju, Jitendra; Yu, Xinxin; Ma, Guoguang Julie

    2013-01-01

    Formal inference in randomized clinical trials is based on controlling the type I error rate associated with a single pre-specified statistic. The deficiency of using just one method of analysis is that it depends on assumptions that may not be met. For robust inference, we propose pre-specifying multiple test statistics and relying on the minimum p-value for testing the null hypothesis of no treatment effect. The null hypothesis associated with the various test statistics is that the treatment groups are indistinguishable. The critical value for hypothesis testing comes from permutation distributions. Rejection of the null hypothesis when the smallest p-value is less than the critical value controls the type I error rate at its designated value. Even if one of the candidate test statistics has low power, the adverse effect on the power of the minimum p-value statistic is not much. Its use is illustrated with examples. We conclude that it is better to rely on the minimum p-value rather than a single statistic particularly when that single statistic is the logrank test, because of the cost and complexity of many survival trials. Copyright © 2013 John Wiley & Sons, Ltd.

  14. Do Students Behave Rationally in Multiple Choice Tests? Evidence from a Field Experiment

    María Paz Espinosa; Javier Gardeazabal

    2013-01-01

    A disadvantage of multiple choice tests is that students have incentives to guess. To discourage guessing, it is common to use scoring rules that either penalize wrong answers or reward omissions. In psychometrics, penalty and reward scoring rules are considered equivalent. However, experimental evidence indicates that students behave differently under penalty or reward scoring rules. These differences have been attributed to the different framing (penalty versus reward). In this paper, we mo...

  15. Relationship between contrast sensitivity test and disease severity in multiple sclerosis patients.

    Soler García, A; González Gómez, A; Figueroa-Ortiz, L C; García-Ben, A; García-Campos, J

    2014-09-01

    To assess the importance of the Pelli-Robson contrast sensitivity test in multiple sclerosis patients according to the Expanded Disability Status Scale (EDSS). A total of 62 patients with multiple sclerosis were included in a retrospective study. Patients were enrolled from the Neurology Department to Neuroophthalmology at Virgen de la Victoria Hospital. Patients were classified into 3 groups according to EDSS: group A) lower than 1.5, group B) between 1.5 and 3.5 and group C) greater than 3.5. Visual acuity and monocular and binocular contrast sensitivity were performed with Snellen and Pelli-Robson tests respectively. Twelve disease-free control participants were also recruited. Correlations between parameter changes were analyzed. The mean duration of the disease was 81.54±35.32 months. Monocular and binocular Pelli-Robson mean values in the control group were 1.82±0.10 and 1.93±0.43 respectively, and 1.61±0.29 and 1.83±0.19 in multiple sclerosis patients. There were statistically significant differences in the monocular analysis for a level of significance P<.05. Mean monocular and binocular Pelli-Robson values in relation to gravity level were, in group A: 1.66±0.24 and 1.90±0.98, group B: 1.64±0.21 and 1.82±0.16, and group C: 1.47±0.45 and 1.73±0.32 respectively. Group differences were statistically significant in both tests: P=.05 and P=.027. Monocular and binocular contrast discrimination analyzed using the Pelli-Robson test was found to be significantly lower when the severity level, according EDSS, increases in multiple sclerosis patients. Copyright © 2013 Sociedad Española de Oftalmología. Published by Elsevier Espana. All rights reserved.

  16. Development and tests of MCP based timing and multiplicity detector for MIPs

    Feofilov, G.; Kondratev, V.; Stolyarov, O.; Tulina, T.; Valiev, F.; Vinogradov, L.

    2017-01-01

    We present summary of technological developments and tests of the MCP based large area detector aimed at precise timing and charged particles multiplicity measurements. Results obtained in course of these developments of isochronous (simultaneity) precise signal readout, passive summation of 1 ns signals, fast (1 GHz) front-end electronics, miniature vacuum systems, etc. could be potentially interesting for a number of future applications in different fields.

  17. Non-parametric comparison of histogrammed two-dimensional data distributions using the Energy Test

    Reid, Ivan D; Lopes, Raul H C; Hobson, Peter R

    2012-01-01

    When monitoring complex experiments, comparison is often made between regularly acquired histograms of data and reference histograms which represent the ideal state of the equipment. With the larger HEP experiments now ramping up, there is a need for automation of this task since the volume of comparisons could overwhelm human operators. However, the two-dimensional histogram comparison tools available in ROOT have been noted in the past to exhibit shortcomings. We discuss a newer comparison test for two-dimensional histograms, based on the Energy Test of Aslan and Zech, which provides more conclusive discrimination between histograms of data coming from different distributions than methods provided in a recent ROOT release.

  18. Multiple testing corrections in quantitative proteomics: A useful but blunt tool.

    Pascovici, Dana; Handler, David C L; Wu, Jemma X; Haynes, Paul A

    2016-09-01

    Multiple testing corrections are a useful tool for restricting the FDR, but can be blunt in the context of low power, as we demonstrate by a series of simple simulations. Unfortunately, in proteomics experiments low power can be common, driven by proteomics-specific issues like small effects due to ratio compression, and few replicates due to reagent high cost, instrument time availability and other issues; in such situations, most multiple testing corrections methods, if used with conventional thresholds, will fail to detect any true positives even when many exist. In this low power, medium scale situation, other methods such as effect size considerations or peptide-level calculations may be a more effective option, even if they do not offer the same theoretical guarantee of a low FDR. Thus, we aim to highlight in this article that proteomics presents some specific challenges to the standard multiple testing corrections methods, which should be employed as a useful tool but not be regarded as a required rubber stamp. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Experiences in simulating and testing coordinated voltage control provided by multiple wind power plants

    Arlaban, T.; Alonso, O.; Ortiz, D. [Acciona Windpower S.A. (Spain); Peiro, J.; Rivas, R. [Red Electrica de Espana SAU (Spain); Quinonez-Varela, G.; Lorenzo, P. [Acciona Energia S.A. (Spain)

    2011-07-01

    This document presents some field tests performed in a transmission system node in order to check the adequacy of voltage control performance by multiple wind power plants, with an overall capacity of 395 MW. It briefly explains the Spanish TSO motivation towards new voltage control requirements and the necessity of performing such tests in order to set the most convenient voltage control parameters and to verify the stable operation. It presents how different the voltage control capability between modern wind turbines (DFIG) and older ones (SCIG) specifically retrofitted for voltage control is. (orig.)

  20. International Test Comparisons: Reviewing Translation Error in Different Source Language-Target Language Combinations

    Zhao, Xueyu; Solano-Flores, Guillermo; Qian, Ming

    2018-01-01

    This article addresses test translation review in international test comparisons. We investigated the applicability of the theory of test translation error--a theory of the multidimensionality and inevitability of test translation error--across source language-target language combinations in the translation of PISA (Programme of International…

  1. Evaluation of MIMIC-Model Methods for DIF Testing with Comparison to Two-Group Analysis

    Woods, Carol M.

    2009-01-01

    Differential item functioning (DIF) occurs when an item on a test or questionnaire has different measurement properties for 1 group of people versus another, irrespective of mean differences on the construct. This study focuses on the use of multiple-indicator multiple-cause (MIMIC) structural equation models for DIF testing, parameterized as item…

  2. Comparison of Cerebral Glucose Metabolism between Possible and Probable Multiple System Atrophy

    Kyum-Yil Kwon

    2009-05-01

    Full Text Available Background: To investigate the relationship between presenting clinical manifestations and imaging features of multisystem neuronal dysfunction in MSA patients, using 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET. Methods: We studied 50 consecutive MSA patients with characteristic brain MRI findings of MSA, including 34 patients with early MSA-parkinsonian (MSA-P and 16 with early MSA-cerebellar (MSA-C. The cerebral glucose metabolism of all MSA patients was evaluated in comparison with 25 age-matched controls. 18F-FDG PET results were assessed by the Statistic Parametric Mapping (SPM analysis and the regions of interest (ROI method. Results: The mean time from disease onset to 18F-FDG PET was 25.9±13.0 months in 34 MSA-P patients and 20.1±11.1 months in 16 MSA-C patients. Glucose metabolism of the putamen showed a greater decrease in possible MSA-P than in probable MSA-P (p=0.031. Although the Unified Multiple System Atrophy Rating Scale (UMSARS score did not differ between possible MSA-P and probable MSA-P, the subscores of rigidity (p=0.04 and bradykinesia (p= 0.008 were significantly higher in possible MSA-P than in probable MSA-P. Possible MSA-C showed a greater decrease in glucose metabolism of the cerebellum than probable MSA-C (p=0.016. Conclusions: Our results may suggest that the early neuropathological pattern of possible MSA with a predilection for the striatonigral or olivopontocerebellar system differs from that of probable MSA, which has prominent involvement of the autonomic nervous system in addition to the striatonigral or olivopontocerebellar system.

  3. Estimating HIV incidence among adults in Kenya and Uganda: a systematic comparison of multiple methods.

    Andrea A Kim

    2011-03-01

    Full Text Available Several approaches have been used for measuring HIV incidence in large areas, yet each presents specific challenges in incidence estimation.We present a comparison of incidence estimates for Kenya and Uganda using multiple methods: 1 Epidemic Projections Package (EPP and Spectrum models fitted to HIV prevalence from antenatal clinics (ANC and national population-based surveys (NPS in Kenya (2003, 2007 and Uganda (2004/2005; 2 a survey-derived model to infer age-specific incidence between two sequential NPS; 3 an assay-derived measurement in NPS using the BED IgG capture enzyme immunoassay, adjusted for misclassification using a locally derived false-recent rate (FRR for the assay; (4 community cohorts in Uganda; (5 prevalence trends in young ANC attendees. EPP/Spectrum-derived and survey-derived modeled estimates were similar: 0.67 [uncertainty range: 0.60, 0.74] and 0.6 [confidence interval: (CI 0.4, 0.9], respectively, for Uganda (2005 and 0.72 [uncertainty range: 0.70, 0.74] and 0.7 [CI 0.3, 1.1], respectively, for Kenya (2007. Using a local FRR, assay-derived incidence estimates were 0.3 [CI 0.0, 0.9] for Uganda (2004/2005 and 0.6 [CI 0, 1.3] for Kenya (2007. Incidence trends were similar for all methods for both Uganda and Kenya.Triangulation of methods is recommended to determine best-supported estimates of incidence to guide programs. Assay-derived incidence estimates are sensitive to the level of the assay's FRR, and uncertainty around high FRRs can significantly impact the validity of the estimate. Systematic evaluations of new and existing incidence assays are needed to the study the level, distribution, and determinants of the FRR to guide whether incidence assays can produce reliable estimates of national HIV incidence.

  4. Statistical Multiplicity in Systematic Reviews of Anaesthesia Interventions: A Quantification and Comparison between Cochrane and Non-Cochrane Reviews

    Imberger, Georgina; Vejlby, Alexandra Hedvig Damgaard; Hansen, Sara Bohnstedt

    2011-01-01

    Systematic reviews with meta-analyses often contain many statistical tests. This multiplicity may increase the risk of type I error. Few attempts have been made to address the problem of statistical multiplicity in systematic reviews. Before the implications are properly considered, the size...... of systematic reviews and aimed to assess whether this quantity is different in Cochrane and non-Cochrane reviews....... of the issue deserves clarification. Because of the emphasis on bias evaluation and because of the editorial processes involved, Cochrane reviews may contain more multiplicity than their non-Cochrane counterparts. This study measured the quantity of statistical multiplicity present in a population...

  5. Test-Retest Reliability of Measures Commonly Used to Measure Striatal Dysfunction across Multiple Testing Sessions: A Longitudinal Study.

    Palmer, Clare E; Langbehn, Douglas; Tabrizi, Sarah J; Papoutsi, Marina

    2017-01-01

    Cognitive impairment is common amongst many neurodegenerative movement disorders such as Huntington's disease (HD) and Parkinson's disease (PD) across multiple domains. There are many tasks available to assess different aspects of this dysfunction, however, it is imperative that these show high test-retest reliability if they are to be used to track disease progression or response to treatment in patient populations. Moreover, in order to ensure effects of practice across testing sessions are not misconstrued as clinical improvement in clinical trials, tasks which are particularly vulnerable to practice effects need to be highlighted. In this study we evaluated test-retest reliability in mean performance across three testing sessions of four tasks that are commonly used to measure cognitive dysfunction associated with striatal impairment: a combined Simon Stop-Signal Task; a modified emotion recognition task; a circle tracing task; and the trail making task. Practice effects were seen between sessions 1 and 2 across all tasks for the majority of dependent variables, particularly reaction time variables; some, but not all, diminished in the third session. Good test-retest reliability across all sessions was seen for the emotion recognition, circle tracing, and trail making test. The Simon interference effect and stop-signal reaction time (SSRT) from the combined-Simon-Stop-Signal task showed moderate test-retest reliability, however, the combined SSRT interference effect showed poor test-retest reliability. Our results emphasize the need to use control groups when tracking clinical progression or use pre-baseline training on tasks susceptible to practice effects.

  6. Comparison of coagulation activity tests in vitro for selected biomaterials

    van Oeveren, W; Haan, J; Lagerman, P; Schoen, T

    Testing of coagulation induced by external communicating medical devices is an International Standardisation Organization (ISO) requirement for products exposed to human blood. Four categories of tests are indicated by ISO 10993/4: a clotting test (partial thromboplastin time; PTT), thrombin

  7. The effects of multiple features of alternatively spliced exons on the KA/KS ratio test

    Chen Feng-Chi

    2006-05-01

    Full Text Available Abstract Background The evolution of alternatively spliced exons (ASEs is of primary interest because these exons are suggested to be a major source of functional diversity of proteins. Many exon features have been suggested to affect the evolution of ASEs. However, previous studies have relied on the KA/KS ratio test without taking into consideration information sufficiency (i.e., exon length > 75 bp, cross-species divergence > 5% of the studied exons, leading to potentially biased interpretations. Furthermore, which exon feature dominates the results of the KA/KS ratio test and whether multiple exon features have additive effects have remained unexplored. Results In this study, we collect two different datasets for analysis – the ASE dataset (which includes lineage-specific ASEs and conserved ASEs and the ACE dataset (which includes only conserved ASEs. We first show that information sufficiency can significantly affect the interpretation of relationship between exons features and the KA/KS ratio test results. After discarding exons with insufficient information, we use a Boolean method to analyze the relationship between test results and four exon features (namely length, protein domain overlapping, inclusion level, and exonic splicing enhancer (ESE frequency for the ASE dataset. We demonstrate that length and protein domain overlapping are dominant factors, and they have similar impacts on test results of ASEs. In addition, despite the weak impacts of inclusion level and ESE motif frequency when considered individually, combination of these two factors still have minor additive effects on test results. However, the ACE dataset shows a slightly different result in that inclusion level has a marginally significant effect on test results. Lineage-specific ASEs may have contributed to the difference. Overall, in both ASEs and ACEs, protein domain overlapping is the most dominant exon feature while ESE frequency is the weakest one in affecting

  8. Semiparametric Allelic Tests for Mapping Multiple Phenotypes: Binomial Regression and Mahalanobis Distance.

    Majumdar, Arunabha; Witte, John S; Ghosh, Saurabh

    2015-12-01

    Binary phenotypes commonly arise due to multiple underlying quantitative precursors and genetic variants may impact multiple traits in a pleiotropic manner. Hence, simultaneously analyzing such correlated traits may be more powerful than analyzing individual traits. Various genotype-level methods, e.g., MultiPhen (O'Reilly et al. []), have been developed to identify genetic factors underlying a multivariate phenotype. For univariate phenotypes, the usefulness and applicability of allele-level tests have been investigated. The test of allele frequency difference among cases and controls is commonly used for mapping case-control association. However, allelic methods for multivariate association mapping have not been studied much. In this article, we explore two allelic tests of multivariate association: one using a Binomial regression model based on inverted regression of genotype on phenotype (Binomial regression-based Association of Multivariate Phenotypes [BAMP]), and the other employing the Mahalanobis distance between two sample means of the multivariate phenotype vector for two alleles at a single-nucleotide polymorphism (Distance-based Association of Multivariate Phenotypes [DAMP]). These methods can incorporate both discrete and continuous phenotypes. Some theoretical properties for BAMP are studied. Using simulations, the power of the methods for detecting multivariate association is compared with the genotype-level test MultiPhen's. The allelic tests yield marginally higher power than MultiPhen for multivariate phenotypes. For one/two binary traits under recessive mode of inheritance, allelic tests are found to be substantially more powerful. All three tests are applied to two different real data and the results offer some support for the simulation study. We propose a hybrid approach for testing multivariate association that implements MultiPhen when Hardy-Weinberg Equilibrium (HWE) is violated and BAMP otherwise, because the allelic approaches assume HWE

  9. Comparison of neutron transport calculations with NRC test results

    Koban, J.; Hofmann, W.

    1981-02-01

    For an exactly defined reactor arrangement (PCA = Pool Critical Assembly) neutron fluxes, neutron spectra and reaction rates for several neutron detectors were calculated by means of one and two dimensional transport codes. An international comparison proved the methods applied at KWU to be adequate. There were difficulties, however, in considering the three dimensions of the assembly which result mainly from its small dimension. This fact applies to all participants who didn't use three dimensional codes. (orig.) [de

  10. PERMANOVA-S: association test for microbial community composition that accommodates confounders and multiple distances.

    Tang, Zheng-Zheng; Chen, Guanhua; Alekseyenko, Alexander V

    2016-09-01

    Recent advances in sequencing technology have made it possible to obtain high-throughput data on the composition of microbial communities and to study the effects of dysbiosis on the human host. Analysis of pairwise intersample distances quantifies the association between the microbiome diversity and covariates of interest (e.g. environmental factors, clinical outcomes, treatment groups). In the design of these analyses, multiple choices for distance metrics are available. Most distance-based methods, however, use a single distance and are underpowered if the distance is poorly chosen. In addition, distance-based tests cannot flexibly handle confounding variables, which can result in excessive false-positive findings. We derive presence-weighted UniFrac to complement the existing UniFrac distances for more powerful detection of the variation in species richness. We develop PERMANOVA-S, a new distance-based method that tests the association of microbiome composition with any covariates of interest. PERMANOVA-S improves the commonly-used Permutation Multivariate Analysis of Variance (PERMANOVA) test by allowing flexible confounder adjustments and ensembling multiple distances. We conducted extensive simulation studies to evaluate the performance of different distances under various patterns of association. Our simulation studies demonstrate that the power of the test relies on how well the selected distance captures the nature of the association. The PERMANOVA-S unified test combines multiple distances and achieves good power regardless of the patterns of the underlying association. We demonstrate the usefulness of our approach by reanalyzing several real microbiome datasets. miProfile software is freely available at https://medschool.vanderbilt.edu/tang-lab/software/miProfile z.tang@vanderbilt.edu or g.chen@vanderbilt.edu Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press.

  11. Agreement analysis comparing iPad LCVA and Sloan testing in multiple sclerosis patients.

    Sattarnezhad, Neda; Farrow, Samantha; Kimbrough, Dorlan; Glanz, Bonnie; Healy, Brian; Chitnis, Tanuja

    2017-06-01

    Visual symptoms are common in multiple sclerosis (MS). Low-contrast visual acuity (LCVA) testing using Sloan charts has demonstrated increased sensitivity for visual deficits compared to high-contrast acuity testing. Computerized testing of visual acuity may facilitate use in the clinic setting. To evaluate the agreement between an iPad-based and Sloan testing of LCVA in a cohort of MS patients. A total of 38 patients with relapsing-remitting MS were enrolled after providing informed written consent at Partners MS Center, Brigham and Women's hospital. Monocular LCVA was measured using retroilluminated Sloan chart and iPad-based LogMAR chart. Number of correct letters and agreement between two measurements were assessed for each eye using Bland-Altman analysis and paired t-test. For both eyes, there was no significant difference in number correct between the two measurements using a paired t-test, and there was high correlation between two measurements (oculus dextrus (OD) r = 0.89, p iPad-based LCVA test shows good agreement with Sloan testing in MS patients.

  12. Comparison of multiple-criteria decision-making methods - results of simulation study

    Michał Adamczak

    2016-12-01

    Full Text Available Background: Today, both researchers and practitioners have many methods for supporting the decision-making process. Due to the conditions in which supply chains function, the most interesting are multi-criteria methods. The use of sophisticated methods for supporting decisions requires the parameterization and execution of calculations that are often complex. So is it efficient to use sophisticated methods? Methods: The authors of the publication compared two popular multi-criteria decision-making methods: the  Weighted Sum Model (WSM and the Analytic Hierarchy Process (AHP. A simulation study reflects these two decision-making methods. Input data for this study was a set of criteria weights and the value of each in terms of each criterion. Results: The iGrafx Process for Six Sigma simulation software recreated how both multiple-criteria decision-making methods (WSM and AHP function. The result of the simulation was a numerical value defining the preference of each of the alternatives according to the WSM and AHP methods. The alternative producing a result of higher numerical value  was considered preferred, according to the selected method. In the analysis of the results, the relationship between the values of the parameters and the difference in the results presented by both methods was investigated. Statistical methods, including hypothesis testing, were used for this purpose. Conclusions: The simulation study findings prove that the results obtained with the use of two multiple-criteria decision-making methods are very similar. Differences occurred more frequently in lower-value parameters from the "value of each alternative" group and higher-value parameters from the "weight of criteria" group.

  13. Salmonella testing of pooled pre-enrichment broth cultures for screening multiple food samples.

    Price, W R; Olsen, R A; Hunter, J E

    1972-04-01

    A method has been described for testing multiple food samples for Salmonella without loss in sensitivity. The method pools multiple pre-enrichment broth cultures into single enrichment broths. The subsequent stages of the Salmonella analysis are not altered. The method was found applicable to several dry food materials including nonfat dry milk, dried egg albumin, cocoa, cottonseed flour, wheat flour, and shredded coconut. As many as 25 pre-enrichment broth cultures were pooled without apparent loss in the sensitivity of Salmonella detection as compared to individual sample analysis. The procedure offers a simple, yet effective, way to increase sample capacity in the Salmonella testing of foods, particularly where a large proportion of samples ordinarily is negative. It also permits small portions of pre-enrichment broth cultures to be retained for subsequent individual analysis if positive tests are found. Salmonella testing of pooled pre-enrichment broths provides increased consumer protection for a given amount of analytical effort as compared to individual sample analysis.

  14. Comparison effectiveness of Dialectic Behavioral Therapy and Behavior Cognitive Therapy on Depression in the Multiple sclerosis

    Narges Zamani

    2017-03-01

    Full Text Available Balsimelli S, Mendes MF, Bertolucci PH, Tilbery CP. Attention impairment associated with relapsing-remitting multiple sclerosis patients with mild incapacity. Arq Neuropsiquiatr 2007;65(2A:262-7. Zamani N, Ahmadi V, Ataie Moghanloo V, Mirshekar S. Comparing the effectiveness of two therapeutic methods of dialectical behavior therapy and cognitive behavior therapy on the improvement of impulsive behavior in the patients suffering  from major depressive disorder (MDD showing a tendency to suicide. J Ilam Univ Med Sci 2014;22(5:45-54. [Full Text in Persian] Sadovnick AD. European charcot foundation lecture: The natural history of multiple sclerosis and gender. J Neurol Sci 2009;286(1-2:1-5. Robins LN. Psychiatric epidemiology. Arch Gen Psychiatry 1984;41(10:931-33. Amato MP, Ponziani G, Siracusa G, Sorbi S. Cognitive dysfunction in early-onset multiple sclerosis. Arch Neurol 2001;58(10:1602-6.  Polman CH, Reingold SC, Banwell B, Michel Clanet M, Cohen JA, Filippi M, et al. Diagnostic criteria for multiple sclerosis: Revisions to the McDonald Criteria. Ann Neurol 2011;69(2:292–302. Zamani N, Farhadi M, Jamilian HR, Habibi M. Effectiveness of dialectical behavior group therapy on expulsive anger. J Arak Univ Med Sci 2015;8(101:35-44. [Full Text in Persian] Young JE, Klosko JS, Weishaar ME. Schema therapy: A Practitioner’s guide. Translated by: Hamidpoor H. New York: Guilford Press; 2003. Linehan M. Dialectical Behavior therapy frequently Asked Questions. Avalaible From: http://behavioraltech.org/downloads/dbtFaq_Cons.pdf. Accessed Sep, 2008. Zamani N, Habibi M, Darvishi M. To compare the effectiveness dialectical behavior therapy and cognitive-behavioral group therapy in reducing depression in mothers of children with disabilities. Arak Med Univ J 2015;18(94:32-42. [Full Text in Persian] Hawton K, Salkous K, Clarck. Cognitive Behavior Therapy for psychiatric problems, a practical guide. Translated by: Ghasemzadeh H. Tehran: Arjomand Pub; 2002

  15. Rapid descriptive sensory methods – Comparison of Free Multiple Sorting, Partial Napping, Napping, Flash Profiling and conventional profiling

    Dehlholm, Christian; Brockhoff, Per B.; Meinert, Lene

    2012-01-01

    is a modal restriction of Napping to specific sensory modalities, directing sensation and still allowing a holistic approach to products. The new methods are compared to Flash Profiling, Napping and conventional descriptive sensory profiling. Evaluations are performed by several panels of expert assessors......Two new rapid descriptive sensory evaluation methods are introduced to the field of food sensory evaluation. The first method, free multiple sorting, allows subjects to perform ad libitum free sortings, until they feel that no more relevant dissimilarities among products remain. The second method...... are applied for the graphical validation and comparisons. This allows similar comparisons and is applicable to single-block evaluation designs such as Napping. The partial Napping allows repetitions on multiple sensory modalities, e.g. appearance, taste and mouthfeel, and shows the average...

  16. Comparisons of auction mechanisms in a multiple unit setting: A consideration for restructuring electric power markets

    Bernard, John Charles

    The objective of this study was to compare the performance of five single sided auctions that could be used in restructured electric power markets across different market sizes in a multiple unit setting. Auction selection would profoundly influence an industry over $200 billion in size in the United States, and the consequences of implementing an inappropriate mechanism would be great. Experimental methods were selected to analyze the auctions. Two rounds of experiments were conducted, the first testing the sealed offer last accepted offer (LAO) and first rejected offer (FRO), and the clock English (ENG) and sealed offer English (SOE) in markets of sizes two and six. The FRO, SOE, and ENG used the same pricing rule. Second round testing was on the LAO, FRO, and the nonuniform price multiple unit Vickrey (MUV) in markets of sizes two, four, and six. Experiments lasted 23 and 75 periods for rounds 1 and 2 respectively. Analysis of variance and contrast analysis were used to examine the data. The four performance measures used were price, efficiency, profits per unit, and supply revelation. Five basic principles were also assessed: no sales at losses, all low cost capacity should be offered and sold, no high cost capacity should sell, and the market should clear. It was expected group size and auction type would affect performance. For all performance measures, group size was a significant variable, with smaller groups showing poorer performance. Auction type was significant only for the efficiency performance measure, where clock auctions outperformed the others. Clock auctions also proved superior for the first four principles. The FRO performed poorly in almost all situations, and should not be a preferred mechanism in any market. The ENG was highly efficient, but expensive for the buyer. The SOE appeared superior to the FRO and ENG. The clock improves efficiency over the FRO while less information kept prices under the ENG. The MUV was superior in revealing costs

  17. Accelerating Multiple Compound Comparison Using LINGO-Based Load-Balancing Strategies on Multi-GPUs

    Lin, Chun-Yuan; Wang, Chung-Hung; Hung, Che-Lun; Lin, Yu-Shiang

    2015-01-01

    Compound comparison is an important task for the computational chemistry. By the comparison results, potential inhibitors can be found and then used for the pharmacy experiments. The time complexity of a pairwise compound comparison is O(n 2), where n is the maximal length of compounds. In general, the length of compounds is tens to hundreds, and the computation time is small. However, more and more compounds have been synthesized and extracted now, even more than tens of millions. Therefore,...

  18. A comparison of conventional mechanical testing techniques with innovative testing techniques for the evaluation of mechanical properties of NPP structural materials

    Liddell, P.A.; Kopriva, R.

    2015-01-01

    The innovative testing methods of Small Punch (SP) and Automated Ball Indentation (ABI) tests are based on the determination of material properties from sub-sized samples. These methods are promising to evaluate the components of nuclear power plants since they preserve the structural integrity of the component. The SP test is a semi-destructive method that employs miniaturised plate-shaped samples of various geometries. The method is based on the penetration of a sample with a semi-spherical punch. The sample deflection is measured throughout the test. The ABI test is a fully automatic test based on multiple indentations at a single penetration location on a polished sample surface with a spherical indenter of various diameters. The purpose of the test is to determine the tensile properties of materials in a non-destructive and localised fashion. A comparison has been made between SP, ABI and conventional tensile tests on the measurement of yield strength for the A533B (JRQ) ferritic steel which is a base metal of the pressure vessels of western PWR. The results show an excellent correlation for both innovative methods and the conventional tensile tests

  19. Memory and other properties of multiple test procedures generated by entangled graphs.

    Maurer, Willi; Bretz, Frank

    2013-05-10

    Methods for addressing multiplicity in clinical trials have attracted much attention during the past 20 years. They include the investigation of new classes of multiple test procedures, such as fixed sequence, fallback and gatekeeping procedures. More recently, sequentially rejective graphical test procedures have been introduced to construct and visualize complex multiple test strategies. These methods propagate the local significance level of a rejected null hypothesis to not-yet rejected hypotheses. In the graph defining the test procedure, hypotheses together with their local significance levels are represented by weighted vertices and the propagation rule by weighted directed edges. An algorithm provides the rules for updating the local significance levels and the transition weights after rejecting an individual hypothesis. These graphical procedures have no memory in the sense that the origin of the propagated significance level is ignored in subsequent iterations. However, in some clinical trial applications, memory is desirable to reflect the underlying dependence structure of the study objectives. In such cases, it would allow the further propagation of significance levels to be dependent on their origin and thus reflect the grouped parent-descendant structures of the hypotheses. We will give examples of such situations and show how to induce memory and other properties by convex combination of several individual graphs. The resulting entangled graphs provide an intuitive way to represent the underlying relative importance relationships between the hypotheses, are as easy to perform as the original individual graphs, remain sequentially rejective and control the familywise error rate in the strong sense. Copyright © 2012 John Wiley & Sons, Ltd.

  20. An alcohol withdrawal test battery measuring multiple behavioral symptoms in mice.

    Metten, Pamela; Schlumbohm, Jason P; Huang, Lawrence C; Greenberg, Gian D; Hack, Wyatt R; Spence, Stephanie E; Crabbe, John C

    2018-05-01

    Despite acceptance that risk for alcohol-use disorder (AUD) has a large genetic component, the identification of genes underlying various components of risk for AUD has been hampered in humans, in part by the heterogeneity of expression of the phenotype. One aspect of AUD is physical dependence. Alcohol withdrawal is a serious consequence of alcohol dependence with multiple symptoms, many of which are seen in multiple species, and can be experienced over a wide-ranging time course. In the present three studies, we developed a battery of withdrawal tests in mice, examining behavioral symptoms from multiple domains that could be measured over time. To permit eventual use of the battery in different strains of mice, we used male and female mice of a genetically heterogeneous stock developed from intercrossing eight inbred strains. Withdrawal symptoms were assessed using commonly used tests after administration of ethanol in vapor for 72 continuous hours. We found significant effects of ethanol withdrawal versus air-breathing controls on nearly all symptoms, spanning 4 days following ethanol vapor inhalation. Withdrawal produced hypothermia, greater neurohyperexcitability (seizures and tremor), anxiety-like behaviors using an apparatus (such as reduced transitions between light and dark compartments), anhedonia (reduced sucrose preference), Straub tail, backward walking, and reductions in activity; however, there were no changes in thermal pain sensitivity, hyper-reactivity to handling, or anxiety-like emergence behaviors in other apparatus. Using these data, we constructed a refined battery of withdrawal tests. Individual differences in severity of withdrawal among different tests were weakly correlated at best. This battery should be useful for identifying genetic influences on particular withdrawal behaviors, which should reflect the influences of different constellations of genes. Published by Elsevier Inc.

  1. Phase-Retrieval Uncertainty Estimation and Algorithm Comparison for the JWST-ISIM Test Campaign

    Aronstein, David L.; Smith, J. Scott

    2016-01-01

    Phase retrieval, the process of determining the exitpupil wavefront of an optical instrument from image-plane intensity measurements, is the baseline methodology for characterizing the wavefront for the suite of science instruments (SIs) in the Integrated Science Instrument Module (ISIM) for the James Webb Space Telescope (JWST). JWST is a large, infrared space telescope with a 6.5-meter diameter primary mirror. JWST is currently NASA's flagship mission and will be the premier space observatory of the next decade. ISIM contains four optical benches with nine unique instruments, including redundancies. ISIM was characterized at the Goddard Space Flight Center (GSFC) in Greenbelt, MD in a series of cryogenic vacuum tests using a telescope simulator. During these tests, phase-retrieval algorithms were used to characterize the instruments. The objective of this paper is to describe the Monte-Carlo simulations that were used to establish uncertainties (i.e., error bars) for the wavefronts of the various instruments in ISIM. Multiple retrieval algorithms were used in the analysis of ISIM phase-retrieval focus-sweep data, including an iterativetransform algorithm and a nonlinear optimization algorithm. These algorithms emphasize the recovery of numerous optical parameters, including low-order wavefront composition described by Zernike polynomial terms and high-order wavefront described by a point-by-point map, location of instrument best focus, focal ratio, exit-pupil amplitude, the morphology of any extended object, and optical jitter. The secondary objective of this paper is to report on the relative accuracies of these algorithms for the ISIM instrument tests, and a comparison of their computational complexity and their performance on central and graphical processing unit clusters. From a phase-retrieval perspective, the ISIM test campaign includes a variety of source illumination bandwidths, various image-plane sampling criteria above and below the Nyquist- Shannon

  2. Multiple Intelligences Profiles of Children with Attention Deficit and Hyperactivity Disorder in Comparison with Nonattention Deficit and Hyperactivity Disorder

    Najafi, Mostafa; Akouchekian, Shahla; Ghaderi, Alireza; Mahaki, Behzad; Rezaei, Mariam

    2017-01-01

    Background: Attention deficit and hyperactivity disorder (ADHD) is a common psychological problem during childhood. This study aimed to evaluate multiple intelligences profiles of children with ADHD in comparison with non-ADHD. Materials and Methods: This cross-sectional descriptive analytical study was done on 50 children of 6–13 years old in two groups of with and without ADHD. Children with ADHD were referred to Clinics of Child and Adolescent Psychiatry, Isfahan University of Medical Scie...

  3. A comparison of rapid diagnostic testing (by plasmodium lactate ...

    Background: The World Health Organization (WHO) considers early and rapid diagnosis as one of the strategies to control malaria. This study compared the performance of Quantitative Buffy Coat (QBC) test and the Plasmodium lactate dehydrogenase (pLDH) rapid diagnostic test (RDT) with microscopy as the gold ...

  4. Comparison of Rapid Malaria Test and Laboratory Microscopy ...

    Michael Horsfall

    ABSTRACT: Blood samples collected from 272 volunteers in two communities of Bayelsa State in the Niger. Delta area were investigated for falciparum malaria parasite using the rapid test based on the detection of soluble antigen and laboratory microscopy test. The data showed that out of the 272 samples collected, ...

  5. Comparison of Germination and Viability Tests for Southern Hardwood Seed

    F. T. Bonner; J. L. Gammage

    1967-01-01

    This paper summarizes a 3-year evaluation of 10 methods for testing germinability and viability of the seed of six species of southern hardwood. In five of the methods, the seeds were germinated. In the others, visual, biochemical, or physical properties were the criteria. Cutting tests were best for sweetgum and Nuttall oak seed, while cutting or water germination...

  6. Comparisons of Test Anxiety Level of Senior Secondary School ...

    Test anxiety has been noted to be a common experience among students and has been found to have a debilitating effect on academic performance and general well-being of affected people. Despite the universality of the experience, the manifestation of test anxiety varies across some psychosocial and demographic ...

  7. A Bayesian decision procedure for testing multiple hypotheses in DNA microarray experiments.

    Gómez-Villegas, Miguel A; Salazar, Isabel; Sanz, Luis

    2014-02-01

    DNA microarray experiments require the use of multiple hypothesis testing procedures because thousands of hypotheses are simultaneously tested. We deal with this problem from a Bayesian decision theory perspective. We propose a decision criterion based on an estimation of the number of false null hypotheses (FNH), taking as an error measure the proportion of the posterior expected number of false positives with respect to the estimated number of true null hypotheses. The methodology is applied to a Gaussian model when testing bilateral hypotheses. The procedure is illustrated with both simulated and real data examples and the results are compared to those obtained by the Bayes rule when an additive loss function is considered for each joint action and the generalized loss 0-1 function for each individual action. Our procedure significantly reduced the percentage of false negatives whereas the percentage of false positives remains at an acceptable level.

  8. LOFT/L9-3, Loss of Fluid Test, Anticipated Transients with Multiple Failures

    1992-01-01

    1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCA is expected to closely model a LPWR LOCA. 2 - Description of test: This was the third of the NRC L9 series of experiments on Anticipated Transients with Multiple Failures. Loss-of-feedwater effects were studied. The experiment was conducted on 7 April 1982

  9. Rapid Aminoglycoside NP Test for Rapid Detection of Multiple Aminoglycoside Resistance in Enterobacteriaceae.

    Nordmann, Patrice; Jayol, Aurélie; Dobias, Jan; Poirel, Laurent

    2017-04-01

    The rapid aminoglycoside NP (Nordmann/Poirel) test was developed to rapidly identify multiple aminoglycoside (AG) resistance in Enterobacteriaceae It is based on the detection of the glucose metabolism related to enterobacterial growth in the presence of a defined concentration of amikacin plus gentamicin. Formation of acid metabolites was evidenced by a color change (orange to yellow) of the red phenol pH indicator. The rapid aminoglycoside NP test was evaluated by using bacterial colonies of 18 AG-resistant isolates producing 16S rRNA methylases, 20 AG-resistant isolates expressing AG-modifying enzymes (acetyl-, adenyl-, and phosphotransferases), and 10 isolates susceptible to AG. Its sensitivity and specificity were 100% and 97%, respectively, compared to the broth dilution method, which was taken as the gold standard for determining aminoglycoside resistance. The test is inexpensive, rapid (<2 h), and implementable worldwide. Copyright © 2017 American Society for Microbiology.

  10. Avoidance test with Eisenia fetida as indicator for the habitat function of soils. Results of a laboratory comparison test

    Hund-Rinke, K. [Fraunhofer Inst. for Molecular Biology and Applied Ecology, Schmallenberg (Germany); Achazi, R.; Warnecke, D. [Free Univ. of Berlin, Inst. for Biology, Berlin (Germany); Roembke, J. [ECT Oekotoxikologie GmbH, Floersheim (Germany)

    2003-07-01

    Intention, Goal, Scope, Background. The habitat function of soils is often assessed using the reproduction test with Eisenia fetida. As this test is rather labour-intensive, an alternative is needed which is less cost-intensive in terms of duration and workload, but gives reasonable results. The avoidance test with E. fetida is a suitable screening test meeting these criteria. However, before a novel test system can be generally recommended it has to be ensured that comparable results are acquired from different laboratories on the basis of the respective test guideline. Objective. The avoidance test with E. fetida was performed as laboratory comparison test. The results were compared with those of the earthworm acute and reproduction tests carried out with the same soils. Methods. The three tests were performed by three laboratories using eight contaminated soils and three control soils. The contaminated soils were mixed with the control soils to obtain different concentrations of the contamination. (orig.)

  11. Comparison of Urine and Oral Fluid for Workplace Drug Testing.

    Casolin, Armand

    2016-09-01

    To determine the relative detection rates of urine versus oral fluid testing in a safety sensitive industry and the correlation with diagnosed substance use disorders and possible impairment at work. The trial involved 1,500 paired urine and oral fluid tests performed in accordance with Australian Standard/New Zealand Standard (AS/NZS) 4308:2008 and AS 4760:2006. Workers who returned a positive test were screened for substance use disorders, as defined by DSM-5, and for possible impairment at work following that particular episode of substance use. Substances were detected in 3.7% (n = 56) of urine samples and 0.5% (n = 8) of oral fluid samples (p < 0.0001). One worker (0.07%) had a substance detected on oral fluid alone versus 49 workers (3.3%) who had substances detected on urine alone. Twelve workers returned a positive result, defined as being consistent with the use of an illicit drug or a controlled substance without a clinical indication and prescription. Nine workers tested positive on urine alone, one on oral fluid alone and two on both (p = 0.0114). Of note, 6/11 workers who tested positive on urine had possible impairment at work and 2/11 had a substance use disorder versus 2/3 and 0/3, respectively, who tested positive on oral fluid. Urine drug testing performed in accordance with AS/NZS 4308:2008 is more likely to detect overall substance use and illicit drug use than oral fluid testing conducted in accordance with AS 4760:2006. Urine testing performed in accordance with AS/NZS 4308:2008 may also be more likely to detect workers with possible impairment at work and substance use disorders than oral fluid testing performed in accordance with AS 4760:2006. © The Author 2016. Published by Oxford University Press.

  12. 20 Years of standard patch testing in an eczema population with focus on patients with multiple contact allergies

    Carlsen, Berit Christina; Menné, Torkil; Johansen, Jeanne Duus

    2007-01-01

    Results of standard patch tests performed with the same methodology in one centre are rarely available over a large time span. This gives the unique opportunity to study not only prevalence but also persistency of contact allergy and characterize subpopulations. The objectives were to investigate...... sensitivity rates and persistencies of patch test results and characterize patients with multiple contact allergies. A 20-year retrospective database-based study of 14 998 patients patch tested with the European Standard Series was performed. 34.5% were sensitized, primarily women. Sensitivity to nickel......(Me)isothiazolinone, and primin and poor for paraben mix. 5.1% were multiple allergic, primarily women, and 90% got diagnosed by the first test. Frequency of multiple allergies increased with age. More multiple- than mono/double-allergic patients were tested multiple times. Persistency and sensitivity rates in a Danish eczema...

  13. Comparison of tests of accommodation for computer users.

    Kolker, David; Hutchinson, Robert; Nilsen, Erik

    2002-04-01

    With the increased use of computers in the workplace and at home, optometrists are finding more patients presenting with symptoms of Computer Vision Syndrome. Among these symptomatic individuals, research supports that accommodative disorders are the most common vision finding. A prepresbyopic group (N= 30) and a presbyopic group (N = 30) were selected from a private practice. Assignment to a group was determined by age, accommodative amplitude, and near visual acuity with their distance prescription. Each subject was given a thorough vision and ocular health examination, then administered several nearpoint tests of accommodation at a computer working distance. All the tests produced similar results in the presbyopic group. For the prepresbyopic group, the tests yielded very different results. To effectively treat symptomatic VDT users, optometrists must assess the accommodative system along with the binocular and refractive status. For presbyopic patients, all nearpoint tests studied will yield virtually the same result. However, the method of testing accommodation, as well as the test stimulus presented, will yield significantly different responses for prepresbyopic patients. Previous research indicates that a majority of patients prefer the higher plus prescription yielded by the Gaussian image test.

  14. Comparison of Geant4 multiple Coulomb scattering models with theory for radiotherapy protons.

    Makarova, Anastasia; Gottschalk, Bernard; Sauerwein, Wolfgang

    2017-07-06

    Usually, Monte Carlo models are validated against experimental data. However, models of multiple Coulomb scattering (MCS) in the Gaussian approximation are exceptional in that we have theories which are probably more accurate than the experiments which have, so far, been done to test them. In problems directly sensitive to the distribution of angles leaving the target, the relevant theory is the Molière/Fano/Hanson variant of Molière theory (Gottschalk et al 1993 Nucl. Instrum. Methods Phys. Res. B 74 467-90). For transverse spreading of the beam in the target itself, the theory of Preston and Koehler (Gottschalk (2012 arXiv:1204.4470)) holds. Therefore, in this paper we compare Geant4 simulations, using the Urban and Wentzel models of MCS, with theory rather than experiment, revealing trends which would otherwise be obscured by experimental scatter. For medium-energy (radiotherapy) protons, and low-Z (water-like) target materials, Wentzel appears to be better than Urban in simulating the distribution of outgoing angles. For beam spreading in the target itself, the two models are essentially equal.

  15. Comparison of Multiple Chronic Obstructive Pulmonary Disease (COPD) Indices in Chinese COPD Patients.

    Zhang, Jinsong; Miller, Anastasia; Li, Yongxia; Lan, Qinqin; Zhang, Ning; Chai, Yanling; Hai, Bing

    2018-04-01

    Chronic obstructive pulmonary disease (COPD) is a serious chronic condition with a global impact. Symptoms of COPD include progressive dyspnea, breathlessness, cough, and sputum production, which have a considerable impact on the lives of patients. In addition to the human cost of living with COPD and the resulting death, COPD entails a huge economic burden on the Chinese population, with patients spending up to one-third of the average family income on COPD management in some regions is clinically beneficial to adopt preventable measures via prudent COPD care utilization, monetary costs, and hospitalizations. Toward this end, this study compared the relative effectiveness of six indices in predicting patient healthcare utilization, cost of care, and patient health outcome. The six assessment systems evaluated included the three multidimensional Body mass index, Obstruction, Dyspnea, Exercise capacity index, Dyspnea, Obstruction, Smoking, Exacerbation (DOSE) index, and COPD Assessment Test index, or the unidimensional measures that best predict the future of patient healthcare utilization, cost of care, and patient health outcome among Chinese COPD patients. Multiple linear regression models were created for each healthcare utilization, cost, and outcome including a single COPD index and the same group of demographic variables for each of the outcomes. We conclude that the DOSE index facilitates the prediction of patient healthcare utilization, disease expenditure, and negative clinical outcomes. Our study indicates that the DOSE index has a potential role beyond clinical predictions. Copyright©2018. The Korean Academy of Tuberculosis and Respiratory Diseases.

  16. Comparison of Statistical Algorithms for the Detection of Infectious Disease Outbreaks in Large Multiple Surveillance Systems

    Farrington, C. Paddy; Noufaily, Angela; Andrews, Nick J.; Charlett, Andre

    2016-01-01

    A large-scale multiple surveillance system for infectious disease outbreaks has been in operation in England and Wales since the early 1990s. Changes to the statistical algorithm at the heart of the system were proposed and the purpose of this paper is to compare two new algorithms with the original algorithm. Test data to evaluate performance are created from weekly counts of the number of cases of each of more than 2000 diseases over a twenty-year period. The time series of each disease is separated into one series giving the baseline (background) disease incidence and a second series giving disease outbreaks. One series is shifted forward by twelve months and the two are then recombined, giving a realistic series in which it is known where outbreaks have been added. The metrics used to evaluate performance include a scoring rule that appropriately balances sensitivity against specificity and is sensitive to variation in probabilities near 1. In the context of disease surveillance, a scoring rule can be adapted to reflect the size of outbreaks and this was done. Results indicate that the two new algorithms are comparable to each other and better than the algorithm they were designed to replace. PMID:27513749

  17. A numerical comparison between the multiple-scales and finite-element solution for sound propagation in lined flow ducts

    Rienstra, S.W.; Eversman, W.

    2001-01-01

    An explicit, analytical, multiple-scales solution for modal sound transmission through slowly varying ducts with mean flow and acoustic lining is tested against a numerical finite-element solution solving the same potential flow equations. The test geometry taken is representative of a high-bypass

  18. [Comparison of eight screening tests for ant-HCV antibody].

    Deguchi, Matsuo; Kagita, Masanori; Yamashita, Naoko; Nakano, Takasi; Tahara, Kazuko; Asari, Seishi; Iwatani, Yoshinori

    2002-09-01

    We compared eight HCV screening tests for detection of anti-HCV antibody; Ortho Quick Chaser HCV Ab (QC), Ortho HCV Ab ELISA III (ELISA), Ortho HVC Ab PA test III (PA), Lumipulse II Ortho HCV (LUMI), IMx HCV.DAINAPACKII (IMx), ARCHITECT HCV (ARCH), Immucheck.F-HCV C50 Ab (Immu), RANREAM HCV Ab Ex II (RAN). Sera from six hundred patients were examined by these eight screening tests. The positive rates of the eight screening tests were from 9.0% to 13.2%. Forty-five sera showed discrepant results between the eight screening tests, and about half of them showed weak positive reaction and/or false positive. Twenty-five of the forty-five sera were negative for ant-HCV antibody in the CHIRON RIBA III confirmatory test, and forty-four of them were negative for HCV-RNA in the PCR method. The agreement rates between the two reagents were from 95.5% to 99.2%, but were not always high between the two reagents that used similar antigen. The specificities and sensitivities evaluated by using the RIBA III confirmatory test were excellent in ELISA, LUMI, IMx, ARCH and Immu. Three BBI seroconversion panels were used to compare the positive readings in the initial stage of HCV infection by eight screening tests. ELISA and ARCH showed the earliest positive readings, and then IMx, LUMI = RAN, PA, QC and Immu in this order. These findings indicate that ELISA and ARCH were the most excellent in the sensitivity, specificity and early diagnosis of HCV infection. However, we must pay attention to the weak positive reaction in the screening tests, because there is a possibility of "false positive".

  19. Personality Testing in Antarctic Expeditioners: Cross Cultural Comparisons and Evidence for Generalizability

    Musson, D. M.; Sandal, G. M.; Harper, M. L.; Helmreich, R. L.

    Antarctica provides an ideal environment in which to study human behaviour under conditions of isolation and confinement. Such research is currently being conducted through several national Antarctic research programs, with the subject pool for these investigations necessarily consisting of individuals from multiple nationalities. Cross-cultural research has shown, however, that psychological traits and individual values may vary significantly between national and ethnic groups. Until now, there has been an implicit assumption that Antarctic personnel are essentially similar from one national program to another and that therefore findings from any one nation's Antarctic program should generalize to another, as well as to other domains such as spaceflight. We believe that it is necessary to validate this assumption through empirical research. This objective of this analysis was to determine the degree of similarity between the psychological testing profiles of Antarctic research personnel from different national Antarctic programs, and to determine the degrees of similarity or difference of these personnel to a normative population. METHODS In separate studies, Antarctic personnel from Australia (n=57), Norway (=37), and Great Britain (n=145) were administered the Personal Characteristics Inventory (PCI) before departing to Antarctica. The PCI is a battery consisting of 11 psychological scales designed to assess specific traits related to achievement and interpersonal competence that have been shown to be particularly salient to human performance under stressful and complex conditions. For comparative normative data, a group of 441 U.S. undergraduate students were also administered the PCI. Due to historical reasons, researchers in this study used 2 versions of the PCI, and only 9 of the 11 scales were directly equivalent. RESULTS For the three national Antarctic groups (Australia, Norway, and Great Britain), no significant variation was found between group mean

  20. Measuring the Consistency in Change in Hepatitis B Knowledge among Three Different Types of Tests: True/False, Multiple Choice, and Fill in the Blanks Tests.

    Sahai, Vic; Demeyere, Petra; Poirier, Sheila; Piro, Felice

    1998-01-01

    The recall of information about Hepatitis B demonstrated by 180 seventh graders was tested with three test types: (1) short-answer; (2) true/false; and (3) multiple-choice. Short answer testing was the most reliable. Suggestions are made for the use of short-answer tests in evaluating student knowledge. (SLD)

  1. Comparison of test methods for mould growth in buildings

    Bonderup, Sirid; Gunnarsen, Lars Bo; Knudsen, Sofie Marie

    2016-01-01

    renovation needs. This is of importance when hidden surface testing would require destructive measures and subsequent renovation. After identifying available methods on the Danish market for assessing mould growth in dwellings, a case study was conducted to test the usefulness of the methods in four......The purpose of this work is to compare a range of test methods and kits for assessing whether a building structure is infested by mould fungi. A further purpose of this work is to evaluate whether air-based methods for sampling fungal emissions provide information qualifying decisions concerning...... methods measure different aspects relating to mould growth and vary in selectivity and precision. The two types of air samples indicated low levels of mould growth, even where the results of the other methods indicated high to moderate growth. With methods based on culture and DNA testing some differences...

  2. COMPARISON OF RESULTS OF THERMAL TESTS OF BALCONY DOORS

    Golubev Stanislav Sergeevich

    2012-10-01

    Full Text Available Results of thermal tests of balcony doors are presented in the article. In the course of the research project, two types of doors were tested. The first type represents a PVC frame door (width 82 mm; it has a triple glazing (4K-16Ar-4-16Ar-K4; its blank part represents a polystyrene sandwich panel (width 40 mm. The second type represents a PVC frame door (width 82 mm, that has a triple glazing (4K-16Ar-4-16Ar-K4 and composite PVC panels. The testing procedure and processing results are described in the article. The test has demonstrated that the thermal resistance value of the balcony door of the first type exceeds the thermal resistance value of the balcony door of the second type.

  3. Comparison of cough reflex test against instrumental assessment of aspiration.

    Miles, Anna; Moore, Sara; McFarlane, Mary; Lee, Fiona; Allen, Jacqueline; Huckabee, Maggie-Lee

    2013-06-13

    Silent aspiration is associated with pneumonia and mortality, and is poorly identified by traditional clinical swallowing evaluation (CSE). The aim of this study was to validate cough reflex testing (CRT) for identification of silent aspiration against aspiration confirmed by instrumental assessment. Cough reflex threshold testing was completed on all patients using inhaled, nebulised citric acid. Within an hour, 80 patients underwent videofluoroscopic study of swallowing (VFSS) and 101 patients underwent fibreoptic endoscopic evaluation of swallowing (FEES). All tests were recorded and analysed by two researchers blinded to the result of the alternate test. Significant associations between CRT result and cough response to aspiration on VFSS (X(2) (2)=11.046, p=.003) and FEES (X(2) (2)=34.079, pacid provide a better predictive measure of silent aspiration. Copyright © 2013 Elsevier Inc. All rights reserved.

  4. Comparison of vibration test results for Atucha II NPP and large scale concrete block models

    Iizuka, S.; Konno, T.; Prato, C.A.

    2001-01-01

    In order to study the soil structure interaction of reactor building that could be constructed on a Quaternary soil, a comparison study of the soil structure interaction springs was performed between full scale vibration test results of Atucha II NPP and vibration test results of large scale concrete block models constructed on Quaternary soil. This comparison study provides a case data of soil structure interaction springs on Quaternary soil with different foundation size and stiffness. (author)

  5. Use of Pearson's Chi-Square for Testing Equality of Percentile Profiles across Multiple Populations.

    Johnson, William D; Beyl, Robbie A; Burton, Jeffrey H; Johnson, Callie M; Romer, Jacob E; Zhang, Lei

    2015-08-01

    In large sample studies where distributions may be skewed and not readily transformed to symmetry, it may be of greater interest to compare different distributions in terms of percentiles rather than means. For example, it may be more informative to compare two or more populations with respect to their within population distributions by testing the hypothesis that their corresponding respective 10 th , 50 th , and 90 th percentiles are equal. As a generalization of the median test, the proposed test statistic is asymptotically distributed as Chi-square with degrees of freedom dependent upon the number of percentiles tested and constraints of the null hypothesis. Results from simulation studies are used to validate the nominal 0.05 significance level under the null hypothesis, and asymptotic power properties that are suitable for testing equality of percentile profiles against selected profile discrepancies for a variety of underlying distributions. A pragmatic example is provided to illustrate the comparison of the percentile profiles for four body mass index distributions.

  6. Defining and Developing "Critical Thinking" Through Devising and Testing Multiple Explanations of the Same Phenomenon

    Etkina, Eugenia; Planinšič, Gorazd

    2015-10-01

    Most physics teachers would agree that one of the main reasons for her/his students to take physics is to learn to think critically. However, for years we have been assessing our students mostly on the knowledge of physics content (conceptually and quantitatively). Only recently have science educators started moving systematically towards achieving and assessing this critical thinking goal. In this paper we seek to show how guiding students to devise and test multiple explanations of observed phenomena can be used to improve their critical thinking.

  7. Pulse Jet Mixer Overblow Testing for Assessment of Loadings During Multiple Overblows

    Pfund, David M.; Bontha, Jagannadha R.; Michener, Thomas E.; Nigl, Franz; Yokuda, Satoru T.; Leigh, Richard J.; Golovich, Elizabeth C.; Baumann, Aaron W.; Kurath, Dean E.; Hoza, Mark; Combs, William H.; Fort, James A.; Bredt, Ofelia P.

    2009-07-20

    The U.S. Department of Energy (DOE) Office of River Protection’s Waste Treatment Plant (WTP) is being designed and built to pretreat and then vitrify a large portion of the wastes in Hanford’s 177 underground waste storage tanks. The WTP consists of three primary facilities: pretreatment, low-activity waste (LAW) vitrification, and high-level waste (HLW) vitrification. The pretreatment facility will receive waste feed from the Hanford tank farms and separate it into 1) a high-volume, low-activity liquid stream stripped of most solids and radionuclides and 2) a much smaller volume of HLW slurry containing most of the solids and most of the radioactivity. Many of the vessels in the pretreatment facility will contain pulse jet mixers (PJMs) that will provide some or all of the mixing in the vessels. This technology was selected for use in so-called “black cell” regions of the WTP, where maintenance capability will not be available for the operating life of the WTP. PJM technology was selected for use in these regions because it has no moving mechanical parts that require maintenance. The vessels with the most concentrated slurries will also be mixed with air spargers and/or steady jets in addition to the mixing provided by the PJMs. This report contains the results of single and multiple PJM overblow tests conducted in a large, ~13 ft-diameter × 15-ft-tall tank located in the high bay of the Pacific Northwest National Laboratory (PNNL) 336 Building test facility. These single and multiple PJM overblow tests were conducted using water and a clay simulant to bound the lower and upper rheological properties of the waste streams anticipated to be processed in the WTP. Hydrodynamic pressures were measured at a number of locations in the test vessel using an array of nine pressure sensors and four hydrophones. These measurements were made under normal and limiting vessel operating conditions (i.e., maximum PJM fluid emptying velocity, maximum and minimum vessel

  8. Pulse Jet Mixer Overblow Testing for Assessment of Loadings During Multiple Overblows

    Pfund, David M.; Bontha, Jagannadha R.; Michener, Thomas E.; Nigl, Franz; Yokuda, Satoru T.; Leigh, Richard J.; Golovich, Elizabeth C.; Baumann, Aaron W.; Kurath, Dean E.; Hoza, Mark; Combs, William H.; Fort, James A.; Bredt, Ofelia P.

    2008-03-03

    The U.S. Department of Energy (DOE) Office of River Protection’s Waste Treatment Plant (WTP) is being designed and built to pretreat and then vitrify a large portion of the wastes in Hanford’s 177 underground waste storage tanks. The WTP consists of three primary facilities: pretreatment, low-activity waste (LAW) vitrification, and high-level waste (HLW) vitrification. The pretreatment facility will receive waste feed from the Hanford tank farms and separate it into 1) a high-volume, low-activity liquid stream stripped of most solids and radionuclides and 2) a much smaller volume of HLW slurry containing most of the solids and most of the radioactivity. Many of the vessels in the pretreatment facility will contain pulse jet mixers (PJMs) that will provide some or all of the mixing in the vessels. This technology was selected for use in so-called “black cell” regions of the WTP, where maintenance capability will not be available for the operating life of the WTP. PJM technology was selected for use in these regions because it has no moving mechanical parts that require maintenance. The vessels with the most concentrated slurries will also be mixed with air spargers and/or steady jets in addition to the mixing provided by the PJMs. This report contains the results of single and multiple PJM overblow tests conducted in a large, ~13 ft-diameter × 15-ft-tall tank located in the high bay of the Pacific Northwest National Laboratory (PNNL) 336 Building test facility. These single and multiple PJM overblow tests were conducted using water and a clay simulant to bound the lower and upper rheological properties of the waste streams anticipated to be processed in the WTP. Hydrodynamic pressures were measured at a number of locations in the test vessel using an array of nine pressure sensors and four hydrophones. These measurements were made under normal and limiting vessel operating conditions (i.e., maximum PJM fluid emptying velocity, maximum and minimum vessel

  9. Comparing long-term results of PASAT and SDMT scores in relation to neuropsychological testing in multiple sclerosis

    Sonder, J.M.; Burggraaff, J.; Knol, D.L.; Polman, C.H.; Uitdehaag, B.M.J.

    2014-01-01

    Background and objectives: The Symbol Digit Modalities Test (SDMT) shows advantages over the Paced Auditory Serial Addition Test (PASAT) as a cognitive test in patients with multiple sclerosis (MS). To determine which of these tests is most valid and reliable over time as an indicator of the

  10. Diagnosis of acute mononucleosis in emergency: comparison of rapid tests

    Federica Scaggiante

    2011-09-01

    Full Text Available Epstein-Barr virus (EBV is a gammaherpesvirus that causes a number of clinical syndromes, including acute mononucleosis.Acute infection with EBV can vary widely with regard to the severity and presentation of illness, ranging from an asymptomatic infection to a serious, life-threatening version of mononucleosis with associated liver damage and splenomegaly. Additionally, other acute viral syndromes, including those caused by hepatitis viruses and cytomegalovirus (CMV, can lead to similar clinical syndromes. The variety of symptoms and the overlap with other viral infections underscore the importance of laboratory testing in the diagnosis of acute EBV-related disease.The purpose of this study was to evaluate the utility of an agglutination test for the detection of heterophile antibodies (Monotest and two EBV-specific rapid immunochromatographic tests (VCA-IgM and VCA-IgG/EBNA-IgG. Heterophile antibody determination is resulted to have not a real diagnostic utility for the low sensibility and specificity of the test. In our experience the only use of VCA-IgG/EBNA-IgG test is sufficient to discriminate between an acute mononucleosis and a past infection.

  11. BRAF mutation testing in solid tumors: a methodological comparison.

    Weyant, Grace W; Wisotzkey, Jeffrey D; Benko, Floyd A; Donaldson, Keri J

    2014-09-01

    Solid tumor genotyping has become standard of care for the characterization of proto-oncogene mutational status, which has traditionally been accomplished with Sanger sequencing. However, companion diagnostic assays and comparable laboratory-developed tests are becoming increasingly popular, such as the cobas 4800 BRAF V600 Mutation Test and the INFINITI KRAS-BRAF assay, respectively. This study evaluates and validates the analytical performance of the INFINITI KRAS-BRAF assay and compares concordance of BRAF status with two reference assays, the cobas test and Sanger sequencing. DNA extraction from FFPE tissue specimens was performed followed by multiplex PCR amplification and fluorescent label incorporation using allele-specific primer extension. Hybridization to a microarray, signal detection, and analysis were then performed. The limits of detection were determined by testing dilutions of mutant BRAF alleles within wild-type background DNA, and accuracy was calculated based on these results. The INFINITI KRAS-BRAF assay produced 100% concordance with the cobas test and Sanger sequencing and had sensitivity equivalent to the cobas assay. The INFINITI assay is repeatable with at least 95% accuracy in the detection of mutant and wild-type BRAF alleles. These results confirm that the INFINITI KRAS-BRAF assay is comparable to traditional sequencing and the Food and Drug Administration-approved companion diagnostic assay for the detection of BRAF mutations. Copyright © 2014 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

  12. Comparison of driving simulator performance and neuropsychological testing in narcolepsy.

    Kotterba, Sylvia; Mueller, Nicole; Leidag, Markus; Widdig, Walter; Rasche, Kurt; Malin, Jean-Pierre; Schultze-Werninghaus, Gerhard; Orth, Maritta

    2004-09-01

    Daytime sleepiness and cataplexy can increase automobile accident rates in narcolepsy. Several countries have produced guidelines for issuing a driving license. The aim of the study was to compare driving simulator performance and neuropsychological test results in narcolepsy in order to evaluate their predictive value regarding driving ability. Thirteen patients with narcolepsy (age: 41.5+/-12.9 years) and 10 healthy control patients (age: 55.1+/-7.8 years) were investigated. By computer-assisted neuropsychological testing, vigilance, alertness and divided attention were assessed. In a driving simulator patients and controls had to drive on a highway for 60 min (mean speed of 100 km/h). Different weather and daytime conditions and obstacles were presented. Epworth Sleepiness Scale-Scores were significantly raised (narcolepsy patients: 16.7+/-5.1, controls: 6.6+/-3.6, P divided attention (56.9+/-25.4) and vigilance (58.7+/-26.8) were in a normal range. There was, however, a high inter-individual difference. There was no correlation between driving performance and neuropsychological test results or ESS Score. Neuropsychological test results did not significantly change in the follow-up. The difficulties encountered by the narcolepsy patient in remaining alert may account for sleep-related motor vehicle accidents. Driving simulator investigations are closely related to real traffic situations than isolated neuropsychological tests. At the present time the driving simulator seems to be a useful instrument judging driving ability especially in cases with ambiguous neuropsychological results.

  13. Graphical Tests for Power Comparison of Competing Designs.

    Hofmann, H; Follett, L; Majumder, M; Cook, D

    2012-12-01

    Lineups have been established as tools for visual testing similar to standard statistical inference tests, allowing us to evaluate the validity of graphical findings in an objective manner. In simulation studies lineups have been shown as being efficient: the power of visual tests is comparable to classical tests while being much less stringent in terms of distributional assumptions made. This makes lineups versatile, yet powerful, tools in situations where conditions for regular statistical tests are not or cannot be met. In this paper we introduce lineups as a tool for evaluating the power of competing graphical designs. We highlight some of the theoretical properties and then show results from two studies evaluating competing designs: both studies are designed to go to the limits of our perceptual abilities to highlight differences between designs. We use both accuracy and speed of evaluation as measures of a successful design. The first study compares the choice of coordinate system: polar versus cartesian coordinates. The results show strong support in favor of cartesian coordinates in finding fast and accurate answers to spotting patterns. The second study is aimed at finding shift differences between distributions. Both studies are motivated by data problems that we have recently encountered, and explore using simulated data to evaluate the plot designs under controlled conditions. Amazon Mechanical Turk (MTurk) is used to conduct the studies. The lineups provide an effective mechanism for objectively evaluating plot designs.

  14. Compaction comparison testing using a modified impact soil tester and nuclear density gauge

    Erchul, R.A.

    1999-07-01

    The purpose of this paper is to compare test results of a modified Impact Soil Tester (IST) on compacted soil with data obtained from the same soil using a nuclear density gauge at the US Army Corp of Engineer's Buena Vista Flood Wall project in Buena Vista, Virginia. The tests were run during construction of the earth flood wall during the summer of 1996. This comparison testing demonstrated the credibility of the procedure developed for the IST as a compacting testing device. The comparison data was obtained on a variety of soils ranging from silty sands to clays. The Flood Wall comparison compaction data for 90% Standard Proctor shows that the results of the IST as modified are consistent with the nuclear density gauge 89% of the time for all types of soil tested. However, if the soils are more cohesive than the results are consistent with the nuclear density gauge 97% of the time. In addition these comparison tests are in general agreement with comparison compaction testing using the same testing techniques and methods of compacted backfill in utility trenches conducted earlier for the Public Works Department, Chesterfield County, Virginia.

  15. Compaction comparison testing using a modified impact soil tester and nuclear density gauge

    Erchul, R.A.

    1999-01-01

    The purpose of this paper is to compare test results of a modified Impact Soil Tester (IST) on compacted soil with data obtained from the same soil using a nuclear density gauge at the US Army Corp of Engineer's Buena Vista Flood Wall project in Buena Vista, Virginia. The tests were run during construction of the earth flood wall during the summer of 1996. This comparison testing demonstrated the credibility of the procedure developed for the IST as a compacting testing device. The comparison data was obtained on a variety of soils ranging from silty sands to clays. The Flood Wall comparison compaction data for 90% Standard Proctor shows that the results of the IST as modified are consistent with the nuclear density gauge 89% of the time for all types of soil tested. However, if the soils are more cohesive than the results are consistent with the nuclear density gauge 97% of the time. In addition these comparison tests are in general agreement with comparison compaction testing using the same testing techniques and methods of compacted backfill in utility trenches conducted earlier for the Public Works Department, Chesterfield County, Virginia

  16. COMPARISON OF THE TEST VARIANTS IN ENTRANCE EXAMINATIONS

    KLŮFA, Jindřich

    2016-12-01

    Full Text Available The paper contains an analysis of the differences of number of points in the test in mathematics between test variants, which were used in the entrance examinations at the Faculty of Business Administration at University of Economics in Prague in 2015. The differences may arise due to the varying difficulty of variants for students, but also because of the different level of knowledge of students who write these variants. This problem we shall study in present paper. The aim of this paper is to study dependence of the results of entrance examinations in mathematics on test variants. The results obtained will be used for further improvement of the admission process at University of Economics.

  17. Comparison of System Identification Methods using Ambient Bridge Test Data

    Andersen, P.; Brincker, Rune; Peeters, B.

    1999-01-01

    In this paper the performance of four different system identification methods is compared using operational data obtained from an ambient vibration test of the Swiss Z24 highway bridge. The four methods are the frequency domain based peak-picking methods, the polyreference LSCE method, the stocha......In this paper the performance of four different system identification methods is compared using operational data obtained from an ambient vibration test of the Swiss Z24 highway bridge. The four methods are the frequency domain based peak-picking methods, the polyreference LSCE method...

  18. Comparison of the Physical Education and Sports School Students' Multiple Intelligence Areas According to Demographic Features

    Aslan, Cem Sinan

    2016-01-01

    The aim of this study is to compare the multiple intelligence areas of a group of physical education and sports students according to their demographic features. In the study, "Multiple Intelligence Scale", consisting of 27 items, whose Turkish validity and reliability study have been done by Babacan (2012) and which is originally owned…

  19. A FIRST COMPARISON OF KEPLER PLANET CANDIDATES IN SINGLE AND MULTIPLE SYSTEMS

    Latham, David W.; Quinn, Samuel N.; Carter, Joshua A.; Holman, Matthew J.; Rowe, Jason F.; Borucki, William J.; Bryson, Stephen T.; Howell, Steve B.; Batalha, Natalie M.; Brown, Timothy M.; Buchhave, Lars A.; Caldwell, Douglas A.; Christiansen, Jessie L.; Ciardi, David R.; Cochran, William D.; Dunham, Edward W.; Fabrycky, Daniel C.; Ford, Eric B.; Gautier, Thomas N. III; Gilliland, Ronald L.

    2011-01-01

    In this Letter, we present an overview of the rich population of systems with multiple candidate transiting planets found in the first four months of Kepler data. The census of multiples includes 115 targets that show two candidate planets, 45 with three, eight with four, and one each with five and six, for a total of 170 systems with 408 candidates. When compared to the 827 systems with only one candidate, the multiples account for 17% of the total number of systems, and one-third of all the planet candidates. We compare the characteristics of candidates found in multiples with those found in singles. False positives due to eclipsing binaries are much less common for the multiples, as expected. Singles and multiples are both dominated by planets smaller than Neptune; 69 +2 -3 % for singles and 86 +2 -5 % for multiples. This result, that systems with multiple transiting planets are less likely to include a transiting giant planet, suggests that close-in giant planets tend to disrupt the orbital inclinations of small planets in flat systems, or maybe even prevent the formation of such systems in the first place.

  20. Estimating the Proportion of True Null Hypotheses in Multiple Testing Problems

    Oluyemi Oyeniran

    2016-01-01

    Full Text Available The problem of estimating the proportion, π0, of the true null hypotheses in a multiple testing problem is important in cases where large scale parallel hypotheses tests are performed independently. While the problem is a quantity of interest in its own right in applications, the estimate of π0 can be used for assessing or controlling an overall false discovery rate. In this article, we develop an innovative nonparametric maximum likelihood approach to estimate π0. The nonparametric likelihood is proposed to be restricted to multinomial models and an EM algorithm is also developed to approximate the estimate of π0. Simulation studies show that the proposed method outperforms other existing methods. Using experimental microarray datasets, we demonstrate that the new method provides satisfactory estimate in practice.

  1. The test beamline of the European Spallation Source - Instrumentation development and wavelength frame multiplication

    Woracek, R.; Hofmann, T.; Bulat, M.

    2016-01-01

    which, in contrast, are all providing short neutron pulses. In order to enable the development of methods and technology adapted to this novel type of source well in advance of the first instruments being constructed at ESS, a test beamline (TBL) was designed and built at the BER II research reactor...... wavelength band between 1.6 A and 10 A by a dedicated wavelength frame multiplication (WFM) chopper system. WFM is proposed for several ESS instruments to allow for flexible time-of-flight resolution. Hence, ESS will benefit from the TBL which offers unique possibilities for testing methods and components....... This article describes the main capabilities of the instrument, its performance as experimentally verified during the commissioning, and its relevance to currently starting ESS instrumentation projects....

  2. Detecting a Weak Association by Testing its Multiple Perturbations: a Data Mining Approach

    Lo, Min-Tzu; Lee, Wen-Chung

    2014-05-01

    Many risk factors/interventions in epidemiologic/biomedical studies are of minuscule effects. To detect such weak associations, one needs a study with a very large sample size (the number of subjects, n). The n of a study can be increased but unfortunately only to an extent. Here, we propose a novel method which hinges on increasing sample size in a different direction-the total number of variables (p). We construct a p-based `multiple perturbation test', and conduct power calculations and computer simulations to show that it can achieve a very high power to detect weak associations when p can be made very large. As a demonstration, we apply the method to analyze a genome-wide association study on age-related macular degeneration and identify two novel genetic variants that are significantly associated with the disease. The p-based method may set a stage for a new paradigm of statistical tests.

  3. Comparison of agal gel precipitation test (AGPT) and enzyme linked ...

    The use of agar gel precipitation test (AGPT) and enzyme linked immunosorbent assay (ELISA) in assaying for the presence of infectious bursal disease (IBD) virus antibody in village chickens in Oyo State, Nigeria, was compared. Out of 400 sera subjected to ELISA, 360 (90%) samples where positive for IBD virus ...

  4. Comparison of agglutination test, microscopy and nPCR for ...

    action (nPCR) for the detection of T. gondii infection in mice (n=399) inoculated with heart .... Direct Agglutination Test (DAT) (Toxo screen DA, Biomerieux®, France) fol- ... 0.3 µl external forward Primer (50 µM), 0.3 µl external reverse Primer.

  5. A field comparison of multiple techniques to quantify groundwater - surface-water interactions

    González-Pinzón, Ricardo; Ward, Adam S; Hatch, Christine E; Wlostowski, Adam N; Singha, Kamini; Gooseff, Michael N.; Haggerty, Roy; Harvey, Judson; Cirpka, Olaf A; Brock, James T

    2015-01-01

    Groundwater–surface-water (GW-SW) interactions in streams are difficult to quantify because of heterogeneity in hydraulic and reactive processes across a range of spatial and temporal scales. The challenge of quantifying these interactions has led to the development of several techniques, from centimeter-scale probes to whole-system tracers, including chemical, thermal, and electrical methods. We co-applied conservative and smart reactive solute-tracer tests, measurement of hydraulic heads, distributed temperature sensing, vertical profiles of solute tracer and temperature in the stream bed, and electrical resistivity imaging in a 450-m reach of a 3rd-order stream. GW-SW interactions were not spatially expansive, but were high in flux through a shallow hyporheic zone surrounding the reach. NaCl and resazurin tracers suggested different surface–subsurface exchange patterns in the upper ⅔ and lower ⅓ of the reach. Subsurface sampling of tracers and vertical thermal profiles quantified relatively high fluxes through a 10- to 20-cm deep hyporheic zone with chemical reactivity of the resazurin tracer indicated at 3-, 6-, and 9-cm sampling depths. Monitoring of hydraulic gradients along transects with MINIPOINT streambed samplers starting ∼40 m from the stream indicated that groundwater discharge prevented development of a larger hyporheic zone, which progressively decreased from the stream thalweg toward the banks. Distributed temperature sensing did not detect extensive inflow of ground water to the stream, and electrical resistivity imaging showed limited large-scale hyporheic exchange. We recommend choosing technique(s) based on: 1) clear definition of the questions to be addressed (physical, biological, or chemical processes), 2) explicit identification of the spatial and temporal scales to be covered and those required to provide an appropriate context for interpretation, and 3) maximizing generation of mechanistic understanding and reducing costs of

  6. Deformable microparticles with multiple functions for drug delivery and device testing

    Thula, Taili T.

    Since the HIV epidemic of the 1990s, researchers have attempted to develop a red blood cell analog. Even though some of these substitutes are now in Phase III of clinical trials, their use is limited by side effects and short half-life in the human body. As a result, there is still a need for an effective erythrocyte analog with minimum immunogenic and side effects, so that it can be used for multiple applications. Finding new approaches to develop more efficient blood substitutes will not only bring valuable advances in the clinical approach, but also in the area of in vitro testing of medical devices. We examined the feasibility of creating a deformable multi-functional, biodegradable, biocompatible particle for applications in drug delivery and device testing. As a preliminary evaluation, we synthesized different types of microcapsules using natural and synthetic polymers, various cross-linking agents, and diverse manufacturing techniques. After fully characterizing of each system, we determined the most promising red blood cell analog in terms of deformability, stability and toxicity. We also examined the encapsulation and release of bovine serum albumin (BSA) within these deformable particles. After removal of cross-linkers, zinc- and copper-alginate microparticles surrounded by multiple polyelectrolyte layers of chitosan oligosaccharide and alginate were deformable and remained stable under physiological pressures applied by the micropipette technique. In addition, multiple coatings decreased toxicity of heavy-metal crosslinked particles. BSA encapsulation and release from chitosan-alginate microspheres were contingent on the crosslinker and number of polyelectrolyte coatings, respectively. Further rheological studies are needed to determine how closely these particles simulate the behavior of erythrocytes. Also, studies on the encapsulation and release of different proteins, including hemoglobin, are needed to establish the desired controlled release of

  7. Validity of the Symbol Digit Modalities Test as a cognition performance outcome measure for multiple sclerosis.

    Benedict, Ralph Hb; DeLuca, John; Phillips, Glenn; LaRocca, Nicholas; Hudson, Lynn D; Rudick, Richard

    2017-04-01

    Cognitive and motor performance measures are commonly employed in multiple sclerosis (MS) research, particularly when the purpose is to determine the efficacy of treatment. The increasing focus of new therapies on slowing progression or reversing neurological disability makes the utilization of sensitive, reproducible, and valid measures essential. Processing speed is a basic elemental cognitive function that likely influences downstream processes such as memory. The Multiple Sclerosis Outcome Assessments Consortium (MSOAC) includes representatives from advocacy organizations, Food and Drug Administration (FDA), European Medicines Agency (EMA), National Institute of Neurological Disorders and Stroke (NINDS), academic institutions, and industry partners along with persons living with MS. Among the MSOAC goals is acceptance and qualification by regulators of performance outcomes that are highly reliable and valid, practical, cost-effective, and meaningful to persons with MS. A critical step for these neuroperformance metrics is elucidation of clinically relevant benchmarks, well-defined degrees of disability, and gradients of change that are deemed clinically meaningful. This topical review provides an overview of research on one particular cognitive measure, the Symbol Digit Modalities Test (SDMT), recognized as being particularly sensitive to slowed processing of information that is commonly seen in MS. The research in MS clearly supports the reliability and validity of this test and recently has supported a responder definition of SDMT change approximating 4 points or 10% in magnitude.

  8. Pretest aerosol code comparisons for LWR aerosol containment tests LA1 and LA2

    Wright, A.L.; Wilson, J.H.; Arwood, P.C.

    1986-01-01

    The Light-Water-Reactor (LWR) Aerosol Containment Experiments (LACE) are being performed in Richland, Washington, at the Hanford Engineering Development Laboratory (HEDL) under the leadership of an international project board and the Electric Power Research Institute. These tests have two objectives: (1) to investigate, at large scale, the inherent aerosol retention behavior in LWR containments under simulated severe accident conditions, and (2) to provide an experimental data base for validating aerosol behavior and thermal-hydraulic computer codes. Aerosol computer-code comparison activities are being coordinated at the Oak Ridge National Laboratory. For each of the six LACE tests, ''pretest'' calculations (for code-to-code comparisons) and ''posttest'' calculations (for code-to-test data comparisons) are being performed. The overall goals of the comparison effort are (1) to provide code users with experience in applying their codes to LWR accident-sequence conditions and (2) to evaluate and improve the code models

  9. The comparison of the unit test tools JUnit and TestNG

    Šarkanj, Aleš

    2011-01-01

    Testing holds an important role in developing software. It is a process ensuring software works as expected. An important part of testing is unit testing as the basic testing level. The purpose of this thesis is comparing JUnit and TestNG, two of the most popular unit testing tools in Java. In the first part we will present testing and its purpose within software development. We will also present the basic terminology and levels of testing. Further on the area of unit testing will be pr...

  10. Within-day variability on short and long walking tests in persons with multiple sclerosis.

    Feys, Peter; Bibby, Bo; Romberg, Anders; Santoyo, Carme; Gebara, Benoit; de Noordhout, Benoit Maertens; Knuts, Kathy; Bethoux, Francois; Skjerbæk, Anders; Jensen, Ellen; Baert, Ilse; Vaney, Claude; de Groot, Vincent; Dalgas, Ulrik

    2014-03-15

    To compare within-day variability of short (10 m walking test at usual and fastest speed; 10MWT) and long (2 and 6-minute walking test; 2MWT/6MWT) tests in persons with multiple sclerosis. Observational study. MS rehabilitation and research centers in Europe and US within RIMS (European network for best practice and research in MS rehabilitation). Ambulatory persons with MS (Expanded Disability Status Scale 0-6.5). Subjects of different centers performed walking tests at 3 time points during a single day. 10MWT, 2MWT and 6MWT at fastest speed and 10MWT at usual speed. Ninety-five percent limits of agreement were computed using a random effects model with individual pwMS as random effect. Following this model, retest scores are with 95% certainty within these limits of baseline scores. In 102 subjects, within-day variability was constant in absolute units for the 10MWT, 2MWT and 6MWT at fastest speed (+/-0.26, 0.16 and 0.15m/s respectively, corresponding to +/-19.2m and +/-54 m for the 2MWT and 6MWT) independent on the severity of ambulatory dysfunction. This implies a greater relative variability with increasing disability level, often above 20% depending on the applied test. The relative within-day variability of the 10MWT at usual speed was +/-31% independent of ambulatory function. Absolute values of within-day variability on walking tests at fastest speed were independent of disability level and greater with short compared to long walking tests. Relative within-day variability remained overall constant when measured at usual speed. Crown Copyright © 2014. Published by Elsevier B.V. All rights reserved.

  11. Eye and hand motor interactions with the Symbol Digit Modalities Test in early multiple sclerosis.

    Nygaard, Gro O; de Rodez Benavent, Sigrid A; Harbo, Hanne F; Laeng, Bruno; Sowa, Piotr; Damangir, Soheil; Bernhard Nilsen, Kristian; Etholm, Lars; Tønnesen, Siren; Kerty, Emilia; Drolsum, Liv; Inge Landrø, Nils; Celius, Elisabeth G

    2015-11-01

    Eye and hand motor dysfunction may be present early in the disease course of relapsing-remitting multiple sclerosis (RRMS), and can affect the results on visual and written cognitive tests. We aimed to test for differences in saccadic initiation time (SI time) between RRMS patients and healthy controls, and whether SI time and hand motor speed interacted with the written version of the Symbol Digit Modalities Test (wSDMT). Patients with RRMS (N = 44, age 35.1 ± 7.3 years), time since diagnosis < 3 years and matched controls (N = 41, age 33.2 ± 6.8 years) were examined with ophthalmological, neurological and neuropsychological tests, as well as structural MRI (white matter lesion load (WMLL) and brainstem lesions), visual evoked potentials (VEP) and eye-tracker examinations of saccades. SI time was longer in RRMS than controls (p < 0.05). SI time was not related to the Paced Auditory Serial Addition Test (PASAT), WMLL or to the presence of brainstem lesions. 9 hole peg test (9HP) correlated significantly with WMLL (r = 0.58, p < 0.01). Both SI time and 9HP correlated negatively with the results of wSDMT (r = -0.32, p < 0.05, r = -0.47, p < 0.01), but none correlated with the results of PASAT. RRMS patients have an increased SI time compared to controls. Cognitive tests results, exemplified by the wSDMT, may be confounded by eye and hand motor function. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

  12. Comparison of CFD simulations with experimental Jet Erosion Tests results

    Mercier, F.; Bonelli, S.; Pinettes, P.; Golay, F.; Anselmet, F.; Philippe, P.

    2014-01-01

    The Jet Erosion Test (JET) is an experimental device increasingly used to quantify the resistance of soils to erosion. This resistance is characterised by two geotechnical parameters: the critical shear stress and the erosion coefficient. The JET interpretation model of Hanson and Cook (2004) provides an estimation of these erosion parameters. But Hanson's model is simplified, semi-empirical and several assumed hypotheses can be discussed. Our aim is to determine the relevance of the JET inte...

  13. The use of regression analysis in determining reference intervals for low hematocrit and thrombocyte count in multiple electrode aggregometry and platelet function analyzer 100 testing of platelet function.

    Kuiper, Gerhardus J A J M; Houben, Rik; Wetzels, Rick J H; Verhezen, Paul W M; Oerle, Rene van; Ten Cate, Hugo; Henskens, Yvonne M C; Lancé, Marcus D

    2017-11-01

    Low platelet counts and hematocrit levels hinder whole blood point-of-care testing of platelet function. Thus far, no reference ranges for MEA (multiple electrode aggregometry) and PFA-100 (platelet function analyzer 100) devices exist for low ranges. Through dilution methods of volunteer whole blood, platelet function at low ranges of platelet count and hematocrit levels was assessed on MEA for four agonists and for PFA-100 in two cartridges. Using (multiple) regression analysis, 95% reference intervals were computed for these low ranges. Low platelet counts affected MEA in a positive correlation (all agonists showed r 2 ≥ 0.75) and PFA-100 in an inverse correlation (closure times were prolonged with lower platelet counts). Lowered hematocrit did not affect MEA testing, except for arachidonic acid activation (ASPI), which showed a weak positive correlation (r 2 = 0.14). Closure time on PFA-100 testing was inversely correlated with hematocrit for both cartridges. Regression analysis revealed different 95% reference intervals in comparison with originally established intervals for both MEA and PFA-100 in low platelet or hematocrit conditions. Multiple regression analysis of ASPI and both tests on the PFA-100 for combined low platelet and hematocrit conditions revealed that only PFA-100 testing should be adjusted for both thrombocytopenia and anemia. 95% reference intervals were calculated using multiple regression analysis. However, coefficients of determination of PFA-100 were poor, and some variance remained unexplained. Thus, in this pilot study using (multiple) regression analysis, we could establish reference intervals of platelet function in anemia and thrombocytopenia conditions on PFA-100 and in thrombocytopenia conditions on MEA.

  14. Comparison of Statistical Methods for Detector Testing Programs

    Rennie, John Alan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Abhold, Mark [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-10-14

    A typical goal for any detector testing program is to ascertain not only the performance of the detector systems under test, but also the confidence that systems accepted using that testing program’s acceptance criteria will exceed a minimum acceptable performance (which is usually expressed as the minimum acceptable success probability, p). A similar problem often arises in statistics, where we would like to ascertain the fraction, p, of a population of items that possess a property that may take one of two possible values. Typically, the problem is approached by drawing a fixed sample of size n, with the number of items out of n that possess the desired property, x, being termed successes. The sample mean gives an estimate of the population mean p ≈ x/n, although usually it is desirable to accompany such an estimate with a statement concerning the range within which p may fall and the confidence associated with that range. Procedures for establishing such ranges and confidence limits are described in detail by Clopper, Brown, and Agresti for two-sided symmetric confidence intervals.

  15. Comparison of parametric and bootstrap method in bioequivalence test.

    Ahn, Byung-Jin; Yim, Dong-Seok

    2009-10-01

    The estimation of 90% parametric confidence intervals (CIs) of mean AUC and Cmax ratios in bioequivalence (BE) tests are based upon the assumption that formulation effects in log-transformed data are normally distributed. To compare the parametric CIs with those obtained from nonparametric methods we performed repeated estimation of bootstrap-resampled datasets. The AUC and Cmax values from 3 archived datasets were used. BE tests on 1,000 resampled datasets from each archived dataset were performed using SAS (Enterprise Guide Ver.3). Bootstrap nonparametric 90% CIs of formulation effects were then compared with the parametric 90% CIs of the original datasets. The 90% CIs of formulation effects estimated from the 3 archived datasets were slightly different from nonparametric 90% CIs obtained from BE tests on resampled datasets. Histograms and density curves of formulation effects obtained from resampled datasets were similar to those of normal distribution. However, in 2 of 3 resampled log (AUC) datasets, the estimates of formulation effects did not follow the Gaussian distribution. Bias-corrected and accelerated (BCa) CIs, one of the nonparametric CIs of formulation effects, shifted outside the parametric 90% CIs of the archived datasets in these 2 non-normally distributed resampled log (AUC) datasets. Currently, the 80~125% rule based upon the parametric 90% CIs is widely accepted under the assumption of normally distributed formulation effects in log-transformed data. However, nonparametric CIs may be a better choice when data do not follow this assumption.

  16. MZDASoft: a software architecture that enables large-scale comparison of protein expression levels over multiple samples based on liquid chromatography/tandem mass spectrometry.

    Ghanat Bari, Mehrab; Ramirez, Nelson; Wang, Zhiwei; Zhang, Jianqiu Michelle

    2015-10-15

    Without accurate peak linking/alignment, only the expression levels of a small percentage of proteins can be compared across multiple samples in Liquid Chromatography/Mass Spectrometry/Tandem Mass Spectrometry (LC/MS/MS) due to the selective nature of tandem MS peptide identification. This greatly hampers biomedical research that aims at finding biomarkers for disease diagnosis, treatment, and the understanding of disease mechanisms. A recent algorithm, PeakLink, has allowed the accurate linking of LC/MS peaks without tandem MS identifications to their corresponding ones with identifications across multiple samples collected from different instruments, tissues and labs, which greatly enhanced the ability of comparing proteins. However, PeakLink cannot be implemented practically for large numbers of samples based on existing software architectures, because it requires access to peak elution profiles from multiple LC/MS/MS samples simultaneously. We propose a new architecture based on parallel processing, which extracts LC/MS peak features, and saves them in database files to enable the implementation of PeakLink for multiple samples. The software has been deployed in High-Performance Computing (HPC) environments. The core part of the software, MZDASoft Parallel Peak Extractor (PPE), can be downloaded with a user and developer's guide, and it can be run on HPC centers directly. The quantification applications, MZDASoft TandemQuant and MZDASoft PeakLink, are written in Matlab, which are compiled with a Matlab runtime compiler. A sample script that incorporates all necessary processing steps of MZDASoft for LC/MS/MS quantification in a parallel processing environment is available. The project webpage is http://compgenomics.utsa.edu/zgroup/MZDASoft. The proposed architecture enables the implementation of PeakLink for multiple samples. Significantly more (100%-500%) proteins can be compared over multiple samples with better quantification accuracy in test cases. MZDASoft

  17. Recall strategies for the verbal fluency test in patients with multiple sclerosis.

    Velázquez-Cardoso, J; Marosi-Holczberger, E; Rodríguez-Agudelo, Y; Yañez-Tellez, G; Chávez-Oliveros, M

    2014-04-01

    Multiple sclerosis (MS) is a neurodegenerative disease characterised by inflammation and demyelination. It generates irreversible myelin changes, which in turn give rise to physical and cognitive disorders. The verbal fluency test (VF) has been shown to be a sensitive tool for detecting cognitive impairment in these patients. To compare quantitative and qualitative aspects of performance on semantic and phonological fluency tests between MS patients and healthy controls by analysing total words produced and strategies used (clusters and switching). We evaluated 46 patients with MS and 33 healthy controls using the VF test. The semantic VF task revealed no significant differences between groups; for the phonological task, patients demonstrated reduced word production (F [77]=2.286 P<.001) and poorer use of grouping strategies, resulting in more frequent switching (F [77]=3.808 P<.005). These results support using qualitative analysis for recall strategies, since the technique provides data about which components of the task are affected by brain damage. Clusters depend on the integrity of semantic memory, while switching has to do with developing effective search strategies, cognitive flexibility, and the ability to modify responses. Frontal lobe damage has been reported in MS, and this is consistent with results from the phonological VF test. Copyright © 2012 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

  18. Proving test on the performance of a Multiple-Excitation Simulator

    Fujita, Katsuhisa; Ito, Tomohiro; Kojima, Nobuyuki; Sasaki, Yoichi; Abe, Hiroshi; Kuroda, Katsuhiko

    1995-01-01

    Seismic excitation test on large scale piping systems is scheduled to be carried out by the Nuclear power Engineering Corporation (NUPEC) using the large-scale, high-performance vibration table at the Tadotsu Engineering Laboratory, under the sponsorship of the Ministry of International Trade and Industry (MITI). In the test, the piping systems simulate the main steam piping system and the main feed water piping system in the nuclear power plants. In this study, a fundamental test was carried out to prove the performance of the Multiple Excitation Simulator which consists of the hydraulic actuator and the control system. An L-shaped piping system and a hydraulic actuator were installed on the shaking table. Acceleration and displacement generated by the actuator were measured. The performance of the actuator and the control system was discussed comparing the measured values and the target values on the time histories and the response spectrum of the acceleration. As a result, it was proved that the actuator and the control system have good performance and will be applicable to the verification test

  19. Comparison of two methods of surface profile extraction from multiple ultrasonic range measurements

    Barshan, B; Baskent, D

    Two novel methods for surface profile extraction based on multiple ultrasonic range measurements are described and compared. One of the methods employs morphological processing techniques, whereas the other employs a spatial voting scheme followed by simple thresholding. Morphological processing

  20. Post-Graduate Student Performance in "Supervised In-Class" vs. "Unsupervised Online" Multiple Choice Tests: Implications for Cheating and Test Security

    Ladyshewsky, Richard K.

    2015-01-01

    This research explores differences in multiple choice test (MCT) scores in a cohort of post-graduate students enrolled in a management and leadership course. A total of 250 students completed the MCT in either a supervised in-class paper and pencil test or an unsupervised online test. The only statistically significant difference between the nine…

  1. Air injection test on a Kaplan turbine: prototype - model comparison

    Angulo, M.; Rivetti, A.; Díaz, L.; Liscia, S.

    2016-11-01

    Air injection is a very well-known resource to reduce pressure pulsation magnitude in turbines, especially on Francis type. In the case of large Kaplan designs, even when not so usual, it could be a solution to mitigate vibrations arising when tip vortex cavitation phenomenon becomes erosive and induces structural vibrations. In order to study this alternative, aeration tests were performed on a Kaplan turbine at model and prototype scales. The research was focused on efficiency of different air flow rates injected in reducing vibrations, especially at the draft tube and the discharge ring and also in the efficiency drop magnitude. It was found that results on both scales presents the same trend in particular for vibration levels at the discharge ring. The efficiency drop was overestimated on model tests while on prototype were less than 0.2 % for all power output. On prototype, air has a beneficial effect in reducing pressure fluctuations up to 0.2 ‰ of air flow rate. On model high speed image computing helped to quantify the volume of tip vortex cavitation that is strongly correlated with the vibration level. The hydrophone measurements did not capture the cavitation intensity when air is injected, however on prototype, it was detected by a sonometer installed at the draft tube access gallery.

  2. Comparison of model propeller tests with airfoil theory

    Durand, William F; Lesley, E P

    1925-01-01

    The purpose of the investigation covered by this report was the examination of the degree of approach which may be anticipated between laboratory tests on model airplane propellers and results computed by the airfoil theory, based on tests of airfoils representative of successive blade sections. It is known that the corrections of angles of attack and for aspect ratio, speed, and interference rest either on experimental data or on somewhat uncertain theoretical assumptions. The general situation as regards these four sets of corrections is far from satisfactory, and while it is recognized that occasion exists for the consideration of such corrections, their determination in any given case is a matter of considerable uncertainty. There exists at the present time no theory generally accepted and sufficiently comprehensive to indicate the amount of such corrections, and the application to individual cases of the experimental data available is, at best, uncertain. While the results of this first phase of the investigation are less positive than had been hoped might be the case, the establishment of the general degree of approach between the two sets of results which might be anticipated on the basis of this simpler mode of application seems to have been desirable.

  3. Model to Test Electric Field Comparisons in a Composite Fairing Cavity

    Trout, Dawn H.; Burford, Janessa

    2013-01-01

    Evaluating the impact of radio frequency transmission in vehicle fairings is important to sensitive spacecraft. This study shows cumulative distribution function (CDF) comparisons of composite a fairing electromagnetic field data obtained by computational electromagnetic 3D full wave modeling and laboratory testing. This work is an extension of the bare aluminum fairing perfect electric conductor (PEC) model. Test and model data correlation is shown.

  4. The Relationship of Deep and Surface Study Approaches on Factual and Applied Test-Bank Multiple-Choice Question Performance

    Yonker, Julie E.

    2011-01-01

    With the advent of online test banks and large introductory classes, instructors have often turned to textbook publisher-generated multiple-choice question (MCQ) exams in their courses. Multiple-choice questions are often divided into categories of factual or applied, thereby implicating levels of cognitive processing. This investigation examined…

  5. Methods for significance testing of categorical covariates in logistic regression models after multiple imputation: power and applicability analysis

    Eekhout, I.; Wiel, M.A. van de; Heymans, M.W.

    2017-01-01

    Background. Multiple imputation is a recommended method to handle missing data. For significance testing after multiple imputation, Rubin’s Rules (RR) are easily applied to pool parameter estimates. In a logistic regression model, to consider whether a categorical covariate with more than two levels

  6. Interlaboratory computational comparisons of critical fast test reactor pin lattices

    Mincey, J.F.; Kerr, H.T.; Durst, B.M.

    1979-01-01

    An objective of the Consolidated Fuel Reprocessing Program's (CFRP) nuclear engineering group at Oak Ridge National Laboratory (ORNL) is to ensure that chemical equipment components designed for the reprocessing of spent LMFBR fuel (among other fuel types) are safe from a criticality standpoint. As existing data are inadequate for the general validation of computational models describing mixed plutonium--uranium oxide systems with isotopic compositions typical of LMFBR fuel, a program of critical experiments has been initiated at the Battelle Pacific Northwest Laboratories (PNL). The first series of benchmark experiments consisted of five square-pitched lattices of unirradiated Fast Test Reactor (FTR) fuel moderated and reflected by light water. Calculations of these five experiments have been conducted by both ORNL/CFRP and PNL personnel with the purpose of exploring how accurately various computational models will predict k/sub eff/ values for such neutronic systems and if differences between k/sub eff/ values obtained with these different models are significant

  7. A comparison of the effects of reflexology and relaxation on pain in women with multiple sclerosis.

    Nazari, Fatemeh; Soheili, Mozhgan; Hosseini, SayedMohsen; Shaygannejad, Vahid

    2016-03-01

    Pain is a common and significant symptom in many individuals with multiple sclerosis (MS). The presence and severity of pain in individuals with MS has also been shown to be associated with higher levels of depression, functional impairment, and fatigue. It is common for MS patients and their caregivers to worry about narcotic addiction in the management of chronic pain. Therefore, this study aimed to determine and compare the effects of reflexology and relaxation on pain in women suffering from MS. This study was a single-blind randomized clinical trial performed on 75 patients with MS referred to the MS Clinic of Ayatollah Kashani Hospital (Isfahan, Iran). After simple non-random sampling, using the minimization method, participants were randomly assigned to the three groups of reflexology, relaxation, and control. In the experimental groups, foot reflexology and relaxation interventions (Jacobson and Benson) were performed within 4 weeks, twice a week for 40 min. The control group received routine care and medical treatment as directed by a doctor. Data were collected using the Numerical Rating Scale before, immediately after, and 2 months after interventions in all three groups. Data analysis was performed using SPSS version 18 and descriptive and inferential statistical tests. Findings obtained from analysis of variance (ANOVA) showed no significant differences between mean pain intensity scores in the three groups preintervention and 2 months after interventions (p > 0.05). However, this difference was statistically significant immediately after the study (p reflexology and relaxation (p  0.05). Furthermore, Fisher's least significant difference (LSD) revealed a significantly higher reduction in pain intensity scores in the reflexology group after the intervention, compared with the two other groups, but showed no significant differences between relaxation and control groups. There were no significant differences between the three groups 2 months

  8. Bench-test comparison of 26 emergency and transport ventilators.

    L'Her, Erwan; Roy, Annie; Marjanovic, Nicolas

    2014-10-15

    Numerous emergency and transport ventilators are commercialized and new generations arise constantly. The aim of this study was to evaluate a large panel of ventilators to allow clinicians to choose a device, taking into account their specificities of use. This experimental bench-test took into account general characteristics and technical performances. Performances were assessed under different levels of FIO2 (100%, 50% or Air-Mix), respiratory mechanics (compliance 30,70,120 mL/cmH2O; resistance 5,10,20 cmH2O/mL/s), and levels of leaks (3.5 to 12.5 L/min), using a test lung. In total 26 emergency and transport ventilators were analyzed and classified into four categories (ICU-like, n = 5; Sophisticated, n = 10; Simple, n = 9; Mass-casualty and military, n = 2). Oxygen consumption (7.1 to 15.8 L/min at FIO2 100%) and the Air-Mix mode (FIO2 45 to 86%) differed from one device to the other. Triggering performance was heterogeneous, but several sophisticated ventilators depicted triggering capabilities as efficient as ICU-like ventilators. Pressurization was not adequate for all devices. At baseline, all the ventilators were able to synchronize, but with variations among respiratory conditions. Leak compensation in most ICU-like and 4/10 sophisticated devices was able to correct at least partially for system leaks, but with variations among ventilators. Major differences were observed between devices and categories, either in terms of general characteristics or technical reliability, across the spectrum of operation. Huge variability of tidal volume delivery with some devices in response to modifications in respiratory mechanics and FIO2 should make clinicians question their use in the clinical setting.

  9. ISP42 (PANDA Tests) - Blind Phase Comparison Report

    Luebbesmeyer, D.; Aksan, S.N.

    2003-05-01

    The International Standard Problem (ISP) No. 45 is part of the overall ISP program of the OECD/NEA and is dedicated to the behavior of heat-up and delayed reflood of fuel elements in nuclear reactors during a hypothetical accident. ISP-45 is related to the out-of-pile bundle quench experiment QUENCH-06, performed at Forschungszentrum Karlsruhe (FZK), Germany, on December 13, 2000. Special attention was paid to hydrogen production. To assess the ability of severe accident codes to simulate processes during core heat-up and reflood at temperatures above 2000 K, the behavior of the bundle during the whole experiment should be calculated on the basis of the necessary experimental initial and boundary conditions, but without knowing further experimental details. In this so-called blind phase 21 participants from 15 nations contributed with 8 different code systems (ATHLET-CD, ICARE/CATHARE, IMPACT/SAMPSON, GENFLO, MAAP, MELCOR, SCDAPSIM, SCDAP-3D). Additionally, posttest calculations using the in-house version SCDAP/RELAP5 mod3.2.irs are used for comparison. After the end of the blind phase all measured data were made available and the participants were invited to deliver a second calculation, where this knowledge could be used (so called open phase). In this report, results of the blind calculations are presented, analyzed, and compared to experimental data. During heat-up most results do not deviate significantly from one another, except as a consequence of some obvious user errors, so that a definition of a mainstream is justified. For the quench phase the lack of adequate hydraulic modeling becomes obvious: some participants could not match the observed cool-down rates, others had to use very fine meshes to compensate code deficiencies. To overcome this insufficiency some newly developed reflood models were used in MAAP and MELCOR. In QUENCH-06, oxide layers were thick enough to protect the cladding from melting and failure below 2200 K, so that no massive hydrogen

  10. Comparison of attitude determination approaches using multiple Global Positioning System (GPS antennas

    Wang Bing

    2013-02-01

    Full Text Available GPS-based attitude system is an important research field, since it is a valuable technique for the attitude determination of platforms. There exist two classes approaches for attitude determination using the GPS. The one determines attitude via baseline estimates in two frames, the other one solves for attitude by incorporating the attitude parameters directly into the GPS measurements. However, comparisons between these two classes approaches have been unexplored. First of all, two algorithms are introduced in detail which on behalf of these two kinds of approaches. Then we present numerical simulations demonstrating the performance of our algorithms and provide a comparison evaluating.

  11. Design of clinical trials involving multiple hypothesis tests with a common control.

    Schou, I Manjula; Marschner, Ian C

    2017-07-01

    Randomized clinical trials comparing several treatments to a common control are often reported in the medical literature. For example, multiple experimental treatments may be compared with placebo, or in combination therapy trials, a combination therapy may be compared with each of its constituent monotherapies. Such trials are typically designed using a balanced approach in which equal numbers of individuals are randomized to each arm, however, this can result in an inefficient use of resources. We provide a unified framework and new theoretical results for optimal design of such single-control multiple-comparator studies. We consider variance optimal designs based on D-, A-, and E-optimality criteria, using a general model that allows for heteroscedasticity and a range of effect measures that include both continuous and binary outcomes. We demonstrate the sensitivity of these designs to the type of optimality criterion by showing that the optimal allocation ratios are systematically ordered according to the optimality criterion. Given this sensitivity to the optimality criterion, we argue that power optimality is a more suitable approach when designing clinical trials where testing is the objective. Weighted variance optimal designs are also discussed, which, like power optimal designs, allow the treatment difference to play a major role in determining allocation ratios. We illustrate our methods using two real clinical trial examples taken from the medical literature. Some recommendations on the use of optimal designs in single-control multiple-comparator trials are also provided. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Reliability and Concurrent Validity of the Narrow Path Walking Test in Persons With Multiple Sclerosis.

    Rosenblum, Uri; Melzer, Itshak

    2017-01-01

    About 90% of people with multiple sclerosis (PwMS) have gait instability and 50% fall. Reliable and clinically feasible methods of gait instability assessment are needed. The study investigated the reliability and validity of the Narrow Path Walking Test (NPWT) under single-task (ST) and dual-task (DT) conditions for PwMS. Thirty PwMS performed the NPWT on 2 different occasions, a week apart. Number of Steps, Trial Time, Trial Velocity, Step Length, Number of Step Errors, Number of Cognitive Task Errors, and Number of Balance Losses were measured. Intraclass correlation coefficients (ICC2,1) were calculated from the average values of NPWT parameters. Absolute reliability was quantified from standard error of measurement (SEM) and smallest real difference (SRD). Concurrent validity of NPWT with Functional Reach Test, Four Square Step Test (FSST), 12-item Multiple Sclerosis Walking Scale (MSWS-12), and 2 Minute Walking Test (2MWT) was determined using partial correlations. Intraclass correlation coefficients (ICCs) for most NPWT parameters during ST and DT ranged from 0.46-0.94 and 0.55-0.95, respectively. The highest relative reliability was found for Number of Step Errors (ICC = 0.94 and 0.93, for ST and DT, respectively) and Trial Velocity (ICC = 0.83 and 0.86, for ST and DT, respectively). Absolute reliability was high for Number of Step Errors in ST (SEM % = 19.53%) and DT (SEM % = 18.14%) and low for Trial Velocity in ST (SEM % = 6.88%) and DT (SEM % = 7.29%). Significant correlations for Number of Step Errors and Trial Velocity were found with FSST, MSWS-12, and 2MWT. In persons with PwMS performing the NPWT, Number of Step Errors and Trial Velocity were highly reliable parameters. Based on correlations with other measures of gait instability, Number of Step Errors was the most valid parameter of dynamic balance under the conditions of our test.Video Abstract available for more insights from the authors (see Supplemental Digital Content 1, available at: http

  13. Using the Coefficient of Determination "R"[superscript 2] to Test the Significance of Multiple Linear Regression

    Quinino, Roberto C.; Reis, Edna A.; Bessegato, Lupercio F.

    2013-01-01

    This article proposes the use of the coefficient of determination as a statistic for hypothesis testing in multiple linear regression based on distributions acquired by beta sampling. (Contains 3 figures.)

  14. Comparison study of imaging features of multiple sclerosis and neuromyelitis optica

    Liu Jianguo; Zhang Hailing; Zheng Kuihong; Zhang Wenluo; Dong Qinwen; Qi Xiaokun

    2012-01-01

    Objective: To compare the imaging characteristics of multiple sclerosis (MS) and neuromyelitis optica (NMO) for better diagnosis and differential diagnosis. Methods: The brain and spinal MRI images of 60 MS and 48 NMO cases were retrospectively reviewed. The imaging characteristics including the predilection site, morphological features, enhancement manifestations were summarized. All data was analyzed by using t test and Chi square test with SPSS 13.0. Results: (1) The three top predilection sites of brain in head MRI of MS patients were periventricular white matter (34 cases in 60), subcortical white matter (27 cases in 60), brain stem (23 cases in 60). MS lesions also were found in basal ganglia, cerebellum, corpus callosum and thalamus,as well as cortex (9 cases in 60). By contrast, brain lesions were observed in 59.4% (19/32) of NMO patients, and the three top predilection sites of NMO by turns were brain stem (13 cases in 19), periventricular white matter (12 cases in 19), subcortical white matter (7 cases in 19). Furthermore, the lesions surrounding third ventricle (6 cases in 19) and the tegmentum of brain stem near peri-aqueduct (8 cases in 19) in NMO were not found in patients of MS. The involvement of brain stem and thalamus was more frequent in NMO than in MS (χ 2 =5.267, 6.004, P<0.05, respectively). (2) The lesions of spinal cord in MS patients were typically oval, peripheral, and asymmetric, but in NMO patients they were longitudinally extensive and centrally located. The mean number of involved vertebral segments in NMO patients was significantly more than that in MS patients (7.3 vs 2.2, t=-9.288, P<0.01). Furthermore, the number of spinal cord lesions in MS patients was remarkably more than that in NMO (2.0 vs 1.3, t=4.565, P<0.01). The ratios of occurrence of spinal cord swelling and distension of NMO patients was 58.3% (28/48), which was significantly higher than 21.9% in MS (7/32, χ 2 =10.370, P<0.01). (3) The enhancement pattern in MS was

  15. Feedback-related brain activity predicts learning from feedback in multiple-choice testing.

    Ernst, Benjamin; Steinhauser, Marco

    2012-06-01

    Different event-related potentials (ERPs) have been shown to correlate with learning from feedback in decision-making tasks and with learning in explicit memory tasks. In the present study, we investigated which ERPs predict learning from corrective feedback in a multiple-choice test, which combines elements from both paradigms. Participants worked through sets of multiple-choice items of a Swahili-German vocabulary task. Whereas the initial presentation of an item required the participants to guess the answer, corrective feedback could be used to learn the correct response. Initial analyses revealed that corrective feedback elicited components related to reinforcement learning (FRN), as well as to explicit memory processing (P300) and attention (early frontal positivity). However, only the P300 and early frontal positivity were positively correlated with successful learning from corrective feedback, whereas the FRN was even larger when learning failed. These results suggest that learning from corrective feedback crucially relies on explicit memory processing and attentional orienting to corrective feedback, rather than on reinforcement learning.

  16. Design of PH-based accelerated life testing plans under multiple-stress-type

    Elsayed, E.A.; Zhang Hao

    2007-01-01

    Accelerated life testing (ALT) is used to obtain failure time data quickly under high stress levels in order to predict product life performance under design stress conditions. Most of the previous work on designing ALT plans is focused on the application of a single stress. However, as components or products become more reliable due to technological advances, it becomes more difficult to obtain significant amount of failure data within reasonable amount of time using single stress only. Multiple-stress-type ALTs have been employed as a means of overcoming such difficulties. In this paper, we design optimum multiple-stress-type ALT plans based on the proportional hazards model. The optimum combinations of stresses and their levels are determined such that the variance of the reliability estimate of the product over a specified period of time is minimized. The use of the model is illustrated using numerical example, and sensitivity analysis shows that the resultant optimum ALT plan is robust to the deviation in model parameters

  17. Force Concept Inventory-based multiple-choice test for investigating students’ representational consistency

    Pasi Nieminen

    2010-08-01

    Full Text Available This study investigates students’ ability to interpret multiple representations consistently (i.e., representational consistency in the context of the force concept. For this purpose we developed the Representational Variant of the Force Concept Inventory (R-FCI, which makes use of nine items from the 1995 version of the Force Concept Inventory (FCI. These original FCI items were redesigned using various representations (such as motion map, vectorial and graphical, yielding 27 multiple-choice items concerning four central concepts underpinning the force concept: Newton’s first, second, and third laws, and gravitation. We provide some evidence for the validity and reliability of the R-FCI; this analysis is limited to the student population of one Finnish high school. The students took the R-FCI at the beginning and at the end of their first high school physics course. We found that students’ (n=168 representational consistency (whether scientifically correct or not varied considerably depending on the concept. On average, representational consistency and scientifically correct understanding increased during the instruction, although in the post-test only a few students performed consistently both in terms of representations and scientifically correct understanding. We also compared students’ (n=87 results of the R-FCI and the FCI, and found that they correlated quite well.

  18. Multiple-tracer tests for contaminant transport process identification in saturated municipal solid waste

    Woodman, N.D.; Rees-White, T.C.; Stringfellow, A.M.; Beaven, R.P.; Hudson, A.P.

    2015-01-01

    Highlights: • Multiple tracers were applied to saturated MSW to test dual-porosity properties. • Lithium demonstrated to be non-conservative as a tracer. • 260 mm diameter column too small to test transport properties of MSW. • The classical advection-dispersion mode was rejected due to high dispersivity. • Characteristic diffusion times did not vary with the tracer. - Abstract: Two column tests were performed in conditions emulating vertical flow beneath the leachate table in a biologically active landfill to determine dominant transport mechanisms occurring in landfills. An improved understanding of contaminant transport process in wastes is required for developing better predictions about potential length of the long term aftercare of landfills, currently measured in timescales of centuries. Three tracers (lithium, bromide and deuterium) were used. Lithium did not behave conservatively. Given that lithium has been used extensively for tracing in landfill wastes, the tracer itself and the findings of previous tests which assume that it has behaved conservatively may need revisiting. The smaller column test could not be fitted with continuum models, probably because the volume of waste was below a representative elemental volume. Modelling compared advection-dispersion (AD), dual porosity (DP) and hybrid AD–DP models. Of these models, the DP model was found to be the most suitable. Although there is good evidence to suggest that diffusion is an important transport mechanism, the breakthrough curves of the different tracers did not differ from each other as would be predicted based on the free-water diffusion coefficients. This suggested that solute diffusion in wastes requires further study

  19. Multiple-tracer tests for contaminant transport process identification in saturated municipal solid waste

    Woodman, N.D., E-mail: n.d.woodman@soton.ac.uk; Rees-White, T.C.; Stringfellow, A.M.; Beaven, R.P.; Hudson, A.P.

    2015-04-15

    Highlights: • Multiple tracers were applied to saturated MSW to test dual-porosity properties. • Lithium demonstrated to be non-conservative as a tracer. • 260 mm diameter column too small to test transport properties of MSW. • The classical advection-dispersion mode was rejected due to high dispersivity. • Characteristic diffusion times did not vary with the tracer. - Abstract: Two column tests were performed in conditions emulating vertical flow beneath the leachate table in a biologically active landfill to determine dominant transport mechanisms occurring in landfills. An improved understanding of contaminant transport process in wastes is required for developing better predictions about potential length of the long term aftercare of landfills, currently measured in timescales of centuries. Three tracers (lithium, bromide and deuterium) were used. Lithium did not behave conservatively. Given that lithium has been used extensively for tracing in landfill wastes, the tracer itself and the findings of previous tests which assume that it has behaved conservatively may need revisiting. The smaller column test could not be fitted with continuum models, probably because the volume of waste was below a representative elemental volume. Modelling compared advection-dispersion (AD), dual porosity (DP) and hybrid AD–DP models. Of these models, the DP model was found to be the most suitable. Although there is good evidence to suggest that diffusion is an important transport mechanism, the breakthrough curves of the different tracers did not differ from each other as would be predicted based on the free-water diffusion coefficients. This suggested that solute diffusion in wastes requires further study.

  20. The benefit of self-testing and interleaving for synthesizing concepts across multiple physiology texts.

    Linderholm, Tracy; Dobson, John; Yarbrough, Mary Beth

    2016-09-01

    A testing-based learning strategy is one that relies on the act of recalling (i.e., testing) information after exposure, and interleaving is a strategy in which the learning materials are presented in a serial order (e.g., texts 1, 2, 3, 1, 2, 3, 1, 2, 3) versus a blocked order (e.g., texts 1, 1, 1, 2, 2, 2, 3, 3, 3). Although both learning strategies have been thoroughly investigated, few studies have examined their additive effect with higher-order cognitive tasks such as the ability to identify themes across multiple texts, and none of those did so using physiology information. The purpose of the present study was to compare recall and thematic processing across five different physiology texts. Participants were randomly assigned to learn the texts using one of the following four learning strategies: 1) study-study-study (S-S-S) using a blocked order, 2) S-S-S using an interleaved order, 3) study-test-study (S-T-S) using a blocked order, and 4) S-T-S using an interleaved order. Over the course of the following week, the S-T-S groups had more stable recall of key text ideas compared with the S-S-S groups, and the S-T-S group had more stable recall of thematic information than the S-S-S group when interleaving was used as the presentation order. Copyright © 2016 The American Physiological Society.

  1. A comparison of in vitro tests and a faecal egg count reduction test in detecting anthelmintic resistance in horse strongyles

    Craven, J.; Bjørn, H.; Barnes, E.H.

    1999-01-01

    This study reports a comparison between faecal egg count reduction test (FECRT), egg hatch assay (EHA) and larval development assay (LDA) for detecting anthelmintic resistance in equine strongyles. Resistance to benzimidazoles was demonstrated in 33 of 42 (79%) farms tested by FECRT and in 32 (62......%) of the 52 farms tested by EHA. As the reference strain used was not fully susceptible to benzimidazoles it was not possible to determine the level of resistance by LDA. Pyrantel resistance was indicated on three of 15 farms by faecal egg count reduction. Resistance was also indicated by LDA for one...

  2. Comparison of CFD and Test Techniques for Cavitation Inception

    Lee, Do Hwan; Park, Sung Keun; Lee, Sun Ki; Kim, Byung Kon

    2009-01-01

    Cavitation erosion on centrifugal pump impellers is a one of the fundamental factors that cause performance degradation and life shortening of the pumps. One approach to estimate the expected life of an impeller is to use sheet cavity length on the blade surface. While observing the cavity length is more suitable to accurately predict the impeller damage, it is not readily available in the field or on the test stand. Recently, the prediction of the cavity length by using commercial CFD codes has been tried by several authors. As an alternative to direct measure the cavity length of an impeller, a means of estimating cavity length of an impeller based on the relation of operating NPSH to that of 3% NPSH and inception NPSH was developed by Cooper. Although this method seems to be attractive, it is not easy to accurately estimate the inception NPSH without flow visualization. Some recent researchers has been paid attention to apply the high frequency Acoustic Emission(AE) technique to detect cavitation inception of pumps. As an effort to better estimate the cavity length without relying on flow visualization, CFD calculations and experiments were performed and then the results are compared in this study

  3. Mathematical methods for quantification and comparison of dissolution testing data

    Edina Vranić

    2002-02-01

    Full Text Available In recent years, drug release/dissolution from solid dosage forms has been the subject of intense and profitable scientific developments. Whenever a new solid dosage form is developed or produced, it is necessary to ensure that drug dissolutionoccurs in an appropriate manner. The pharmaceutical industry and the registration authorities do focus, nowadays, on drug dissolution studies. The quantitative analysis of the values obtained in dissolution/release tests is easier when mathematicalformulas that express the dissolution results as a function of some of the dosage forms characteristics are used. This work discusses the analysis of data obtained for dissolution profiles under different media pH conditions using mathematical methodsof analysis described by Moore and Flanner. These authors have described difference factor (f1 and similarity factor (f2, which can be used to characterise drug dissolution/release profiles. In this work we have used these formulas for evaluation of dissolution profiles of the conventional tablets in different pH of dissolution medium (range of physiological variations.

  4. Mathematical methods for quantification and comparison of dissolution testing data.

    Vranić, Edina; Mehmedagić, Aida; Hadzović, Sabira

    2002-12-01

    In recent years, drug release/dissolution from solid dosage forms has been the subject of intense and profitable scientific developments. Whenever a new solid dosage form is developed or produced, it is necessary to ensure that drug dissolution occurs in an appropriate manner. The pharmaceutical industry and the registration authorities do focus, nowadays, on drug dissolution studies. The quantitative analysis of the values obtained in dissolution/release tests is easier when mathematical formulas that express the dissolution results as a function of some of the dosage forms characteristics are used. This work discusses the analysis of data obtained for dissolution profiles under different media pH conditions using mathematical methods of analysis described by Moore and Flanner. These authors have described difference factor (f1) and similarity factor (f2), which can be used to characterise drug dissolution/release profiles. In this work we have used these formulas for evaluation of dissolution profiles of the conventional tablets in different pH of dissolution medium (range of physiological variations).

  5. The Predictive Validity of using Admissions Testing and Multiple Mini-interviews in Undergraduate University Admissions

    Makransky, Guido; Havmose, Philip S.; Vang, Maria Louison

    2017-01-01

    The aim of this study was to evaluate the predictive validity of a two-step admissions procedure that included a cognitive ability test followed by multiple mini-interviews (MMI) used to assess non-cognitive skills compared to a grade-based admissions relative to subsequent drop-out rates...... and academic achievement after one and two years of study. The participants consisted of the entire population of 422 psychology students who were admitted to the University of Southern Denmark between 2010 and 2013. The results showed significantly lower drop-out rates after the first year of study, and non......-significant lower drop-out rates after the second year of study for the admission procedure that included the assessment of non-cognitive skills though the MMI. Furthermore, this admission procedure resulted in a significant lower risk of failing the final exam after the first and second year of study, compared...

  6. Quantitative analysis of the pendulum test: application to multiple sclerosis patients treated with botulinum toxin.

    Bianchi, L; Monaldi, F; Paolucci, S; Iani, C; Lacquaniti, F

    1999-01-01

    The aim of this study was to develop quantitative analytical methods in the application of the pendulum test to both normal and spastic subjects. The lower leg was released by a torque motor from different starting positions. The resulting changes in the knee angle were fitted by means of a time-varying model. Stiffness and viscosity coefficients were derived for each half-cycle oscillation in both flexion and extension, and for all knee starting positions. This method was applied to the assessment of the effects of Botulinum toxin A (BTX) in progressive multiple sclerosis patients in a follow-up study. About half of the patients showed a significant decrement in stiffness and viscosity coefficients.

  7. Shared Authentic Leadership in Research Teams: Testing a Multiple Mediation Model.

    Guenter, Hannes; Gardner, William L; Davis McCauley, Kelly; Randolph-Seng, Brandon; Prabhu, Veena P

    2017-12-01

    Research teams face complex leadership and coordination challenges. We propose shared authentic leadership (SAL) as a timely approach to addressing these challenges. Drawing from authentic and functional leadership theories, we posit a multiple mediation model that suggests three mechanisms whereby SAL influences team effectiveness: shared mental models (SMM), team trust, and team coordination. To test our hypotheses, we collected survey data on leadership and teamwork within 142 research teams that recently published an article in a peer-reviewed management journal. The results indicate team coordination represents the primary mediating mechanism accounting for the relationship between SAL and research team effectiveness. While teams with high trust and SMM felt more successful and were more satisfied, they were less successful in publishing in high-impact journals. We also found the four SAL dimensions (i.e., self-awareness, relational transparency, balanced processing, and internalized moral perspective) to associate differently with team effectiveness.

  8. WTA estimates using the method of paired comparison: tests of robustness

    Patricia A. Champ; John B. Loomis

    1998-01-01

    The method of paired comparison is modified to allow choices between two alternative gains so as to estimate willingness to accept (WTA) without loss aversion. The robustness of WTA values for two public goods is tested with respect to sensitivity of theWTA measure to the context of the bundle of goods used in the paired comparison exercise and to the scope (scale) of...

  9. Multiple sclerosis test or the 4 humors: cerebrospinal fluid serum, tears and saliva; Esclerosis multiple test de los 4 humores: liquido cefalorraquideo, suero, lagrimas y saliva

    Oehninger Gatti, C; Buzo Del Puerto, R; Chouza Antelo, C; Scotti Bianchi, C; Cibils, D; Alcantara Pelaez, J; Gomez, A; Heuguerot Oliveira, C

    1994-12-15

    4 were studied biological fluids easily accessible to the immune exploration (cerebrospinal fluid, serum, tears and saliva) in 25 patients with Multiple Sclerosis (MS) during a push clinical disease. The level of interleukin-2 receptor soluble (RsIL-2) was significantly increased by at least 3 of these 4 fluids, compared with normal controls. The sensitivity and specificity of its determination for the diagnosis of the condition was higher than other immunochemical parameters, oligoclonal distribution (OD) of immunoglobulin (Ig) light chain imbalance-and-evoked electrophysiological studies. This method is used to establish a more accurate diagnosis of Multiple Sclerosis as well as to monitor its biological activity with nuclear magnetic resonance (NMR) (Author) [Spanish] Se estudiaron 4 fluidos biologicos de facil acceso a la exploracion inmune (liquido cefalorraquideo, suero, lagrimas y saliva) en 25 pacientes con Esclerosis Multiple (EM) obtenidos durante un empuje clinico de la enfermedad. El nivel del receptor de Interleukina-2 soluble (RsIL-2) se encontro significativamente aumentado en por lo menos 3 de estos 4 fluidos, en comparacion con el de los controles normales. La sensibilidad y especificidad de su determinacion para el diagnostico de la afeccion, fue mayor que la de otros parametros inmunoquimicos - distribucion oligoclonal (DO) de inmunoglobulinas (Ig), disbalance de cadenas livianas - y estudios electrofisiologicos -potenciales evocados-. Este metodo es utilizado para establecer un diagnostico mas certero de la Esclerosis Multiple asi como tambien para monitorizar su actividad biologica junto con la resonancia magnetica nuclear (RMN)(Author)

  10. Comparisons of ROSA-III and FIST BWR loss of coolant accident simulation tests

    Tasaka, Kanji; Suzuki, Mitsuhiro; Koizumi, Yasuo

    1985-10-01

    A common understanding and interpretation of BWR system response and the controlling phenomena in LOCA transients has been achieved through the evaluation and comparison of counterpart tests performed in the ROSA-III and FIST test facilities. These facilities, which are designed to simulate the thermal-hydraulic response of BWR systems, are operated respectively by the Japan Atomic Energy Research Institute (JAERI) and the General Electric Company. Comparison is made between three types of counterpart tests, each performed under similar tests conditions in the two facilities. They are large break, small break, and steamline break LOCA's. The system responses to these tests in each facility are quite similar. The sequence of events are similar, and the timing of these events are similar. Differences that do occur are due to minor differences in modeling objectives, facility scaling, and test conditions. Parallel channel flow interactions effects in the ROSA-III four channel (half length) core, although noticeable in the large break test, do not result in major differences with the single channel response in FIST. In the small break tests the timing of events is offset by the earlier ADS actuation in FIST. The steamline test responses are similar except there is no heatup in FIST, resulting from a different ECCS trip modeling. Overall comparisons between ROSA-III and FIST system responses in LOCA tests is very good. (author)

  11. Comparison of Multiple-Microphone and Single-Loudspeaker Adaptive Feedback/Echo Cancellation Systems

    Guo, Meng; Elmedyb, Thomas Bo; Jensen, Søren Holdt

    2011-01-01

    Recently, we introduced a frequency domain measure - the power transfer function - to predict the convergence rate, system stability bound and the steady-state behavior across time and frequency of a least mean square based feedback/echo cancellation algorithm in a general multiple-microphone and......Recently, we introduced a frequency domain measure - the power transfer function - to predict the convergence rate, system stability bound and the steady-state behavior across time and frequency of a least mean square based feedback/echo cancellation algorithm in a general multiple...

  12. Comparison of multiplicity distributions to the negative binomial distribution in muon-proton scattering

    Arneodo, M.; Ferrero, M.I.; Peroni, C.; Bee, C.P.; Bird, I.; Coughlan, J.; Sloan, T.; Braun, H.; Brueck, H.; Drees, J.; Edwards, A.; Krueger, J.; Montgomery, H.E.; Peschel, H.; Pietrzyk, U.; Poetsch, M.; Schneider, A.; Dreyer, T.; Ernst, T.; Haas, J.; Kabuss, E.M.; Landgraf, U.; Mohr, W.; Rith, K.; Schlagboehmer, A.; Schroeder, T.; Stier, H.E.; Wallucks, W.

    1987-01-01

    The multiplicity distributions of charged hadrons produced in the deep inelastic muon-proton scattering at 280 GeV are analysed in various rapidity intervals, as a function of the total hadronic centre of mass energy W ranging from 4-20 GeV. Multiplicity distributions for the backward and forward hemispheres are also analysed separately. The data can be well parameterized by binomial distributions, extending their range of applicability to the case of lepton-proton scattering. The energy and the rapidity dependence of the parameters is presented and a smooth transition from the binomial distribution via Poissonian to the ordinary binomial is observed. (orig.)

  13. The relationship between Test Takers’ Multiple Intelligences and Their Performance on the Reading Sections of TOEFL and IELTS

    Minoo Alemi

    2010-04-01

    Full Text Available The present study aimed at investigating the hypothetical relationship between the multiple intelligences of test takers and their performance on the reading sections of TOEFL and IELTS. Howard Gardner’s theory of multiple intelligences suggests that intelligence is not a single and solely inborn capacity, rather a multiple construct which is only partly genetic, and can be crystallized or paralyzed over one’s lifetime. Based on the theory, there are eight types of intelligence: linguistic, mathematical, musical, bodily, spatial, intrapersonal, interpersonal and naturalist, but the list is not exhaustive. The multiple intelligences of test takers were estimated by means of MIDAS, the Multiple Intelligences Developmental Assessment Scales, developed by Shearer (1994. Subsequently, the bias detection for the reading section of TOEFL was carried out on 90 participants, and this subtest was found to correlate positively with linguistic and logical intelligences. By the same token, 89 out of the 163 participants in the study were included in the analysis of the relationship between the multiple intelligences of test takers and their performance on the reading section of IELTS, and this test proved biased toward linguistic and spatial intelligences. The implications concern the inadequacy of the definition of language proficiency .Moreover, Measurement-Driven Instruction courses and preparatory materials of the two proficiency tests, TOEFL and IELTS, can benefit from the results of the study by being designed in such a way as to represent the intelligences which are positively correlated with performance on the tests in question.

  14. Westinghouse-Gothic comparisons with passive containment cooling tests using a one-to-ten-scale test facility

    Kennedy, M.D.; Woodcock, J.; Wright, R.F.; Gresham, J.A.

    1996-01-01

    The Heavy Water Reactor Facility is equipped with a passive cooling system to provide long-term decay heat removal during postulated beyond-design-basis accidents. The passive containment cooling system (PCCS) consists of an annular space between the steel containment vessel and the concrete shield building and optimized inlet and chimney designs. The design, analysis, and regulatory acceptance of a plant with PCCS requires an understanding of the external convective and radiative heat transfer phenomena, as well as the internal distributions of noncondensable gases. The internal distribution of noncondensable gases has a strong effect on the resistance to condensation heat transfer and therefore affects the wall temperature distribution applied to the external channel. To evaluate these phenomena, a test facility having a scale of approximately one to ten, known as the large-scale test, was constructed, and several series of tests were performed. Test results have been used to validate the Westinghouse-GOTHIC (WGOTHIC) computer code. A comparison of WGOTHIC predictions and test results has been completed. This paper shows that mixed-convection models applied to the interior and exterior surfaces as well as a heat and mass transfer analogy for internal condensation provides good comparison to test results. An axial distribution of noncondensables within the test vessel is also predicted

  15. A comparison of test statistics for the recovery of rapid growth-based enumeration tests

    van den Heuvel, Edwin R.; IJzerman-Boon, Pieta C.

    This paper considers five test statistics for comparing the recovery of a rapid growth-based enumeration test with respect to the compendial microbiological method using a specific nonserial dilution experiment. The finite sample distributions of these test statistics are unknown, because they are

  16. LEARNING AND MEMORY TESTS IN DEVELOPMENTAL NEUROTOXICITY TESTING: A CROSS-LABORATORY COMPARISON OF CONTROL DATA.

    The US EPA Developmental Neurotoxicity (DNT) Study Test Guideline (OPPTS 870.6300) calls for functional tests to assess the impact of chemicals on cognitive function in offspring following maternal exposure. A test of associative learning and memory is to be conducted around th...

  17. Comparison and transfer testing of multiplex ligation detection methods for GM plants

    Ujhelyi Gabriella

    2012-01-01

    Full Text Available Abstract Background With the increasing number of GMOs on the global market the maintenance of European GMO regulations is becoming more complex. For the analysis of a single food or feed sample it is necessary to assess the sample for the presence of many GMO-targets simultaneously at a sensitive level. Several methods have been published regarding DNA-based multidetection. Multiplex ligation detection methods have been described that use the same basic approach: i hybridisation and ligation of specific probes, ii amplification of the ligated probes and iii detection and identification of the amplified products. Despite they all have this same basis, the published ligation methods differ radically. The present study investigated with real-time PCR whether these different ligation methods have any influence on the performance of the probes. Sensitivity and the specificity of the padlock probes (PLPs with the ligation protocol with the best performance were also tested and the selected method was initially validated in a laboratory exchange study. Results Of the ligation protocols tested in this study, the best results were obtained with the PPLMD I and PPLMD II protocols and no consistent differences between these two protocols were observed. Both protocols are based on padlock probe ligation combined with microarray detection. Twenty PLPs were tested for specificity and the best probes were subjected to further evaluation. Up to 13 targets were detected specifically and simultaneously. During the interlaboratory exchange study similar results were achieved by the two participating institutes (NIB, Slovenia, and RIKILT, the Netherlands. Conclusions From the comparison of ligation protocols it can be concluded that two protocols perform equally well on the basis of the selected set of PLPs. Using the most ideal parameters the multiplicity of one of the methods was tested and 13 targets were successfully and specifically detected. In the

  18. Benefits and challenges of using the cohort multiple randomised controlled trial design for testing an intervention for depression.

    Viksveen, Petter; Relton, Clare; Nicholl, Jon

    2017-07-06

    Trials which test the effectiveness of interventions compared with the status quo frequently encounter challenges. The cohort multiple randomised controlled trial (cmRCT) design is an innovative approach to the design and conduct of pragmatic trials which seeks to address some of these challenges. In this article, we report our experiences with the first completed randomised controlled trial (RCT) using the cmRCT design. This trial-the Depression in South Yorkshire (DEPSY) trial-involved comparison of treatment as usual (TAU) with TAU plus the offer of an intervention for people with self-reported long-term moderate to severe depression. In the trial, we used an existing large population-based cohort: the Yorkshire Health Study. We discuss our experiences with recruitment, attrition, crossover, data analysis, generalisability of results, and cost. The main challenges in using the cmRCT design were the high crossover to the control group and the lower questionnaire response rate among patients who refused the offer of treatment. However, the design did help facilitate efficient and complete recruitment of the trial population as well as analysable data that were generalisable to the population of interest. Attrition rates were also smaller than those reported in other depression trials. This first completed full trial using the cmRCT design testing an intervention for self-reported depression was associated with a number of important benefits. Further research is required to compare the acceptability and cost effectiveness of standard pragmatic RCT design with the cmRCT design. ISRCTN registry: ISRCTN02484593 . Registered on 7 Jan 2013.

  19. Clinical usefulness of serum free light chains measurement in patients with multiple myeloma: comparative analysis of two different tests

    Tadeusz Kubicki

    2017-01-01

    Full Text Available Introduction: There are two commercially available tests for measurement of serum free light chains (sFLC in multiple myeloma (MM patients – Freelite and N Latex FLC. The aim of this study was to perform an assessment and direct comparison of the usefulness of the methods in routine clinical practice.Methods: 40 refractory/relapsed MM patients underwent routine disease activity assessment studies, along with sFLC analysis using both assays. Correlation and concordance between the tests and sensitivity of studied methods of sFLC assessment were established. Special attention was focused on sFLC results in patients finally evaluated after completing the treatment. Results: A weak correlation for the measurement of both κ [Passing–Bablok slope (PB = 0.7681] and λ chains [(PB = 1.542] was found. Using Bland–Altman plots, a bias of 0.0467 (κ and -0.2133 (λ between the measurements was documented. The concordance coefficient equaled 0.87 for κ, 0.62 for λ and 0.52 for κ/λ ratio. Ten patients had an abnormal Freelite assay κ/λ ratio and normal N Latex FLC κ/λ ratio. Three of these patients had negative serum protein electrophoresis results and fulfilled diagnostic criteria of stringent complete remission (sCR according to N Latex FLC (but not according to Freelite. When the κ/λ ratio obtained by both methods was compared to patients’ serum/urine protein electrophoresis and immunofixation results, sensitivity of Freelite and N Latex FLC was established to be 62.5% and 41%, respectively. Conclusions: There was no strong correlation or concordance between the two assays, and the sensitivity in terms of sFLC detection was different. This may cause problems when diagnosis of sCR is considered.

  20. Pump testing - Comparison of factory vs. field test of centrifugal pumps

    Fehlau, R.

    1992-01-01

    Testing of pumps in situ, i.e., as installed in a system, will typically yield somewhat different performance results from the original manufacturer's factory test. This paper discusses some of the reasons for these variations. It shows that the factory test curves can be used for evaluation of initial acceptance tests but not for reference in normal inservice testing (IST). This is the basis for reference values used in American Society of Mechanical Engineers (ASME) Section 11 specifications and the revised ASME Code 1990

  1. The comparison between several robust ridge regression estimators in the presence of multicollinearity and multiple outliers

    Zahari, Siti Meriam; Ramli, Norazan Mohamed; Moktar, Balkiah; Zainol, Mohammad Said

    2014-09-01

    In the presence of multicollinearity and multiple outliers, statistical inference of linear regression model using ordinary least squares (OLS) estimators would be severely affected and produces misleading results. To overcome this, many approaches have been investigated. These include robust methods which were reported to be less sensitive to the presence of outliers. In addition, ridge regression technique was employed to tackle multicollinearity problem. In order to mitigate both problems, a combination of ridge regression and robust methods was discussed in this study. The superiority of this approach was examined when simultaneous presence of multicollinearity and multiple outliers occurred in multiple linear regression. This study aimed to look at the performance of several well-known robust estimators; M, MM, RIDGE and robust ridge regression estimators, namely Weighted Ridge M-estimator (WRM), Weighted Ridge MM (WRMM), Ridge MM (RMM), in such a situation. Results of the study showed that in the presence of simultaneous multicollinearity and multiple outliers (in both x and y-direction), the RMM and RIDGE are more or less similar in terms of superiority over the other estimators, regardless of the number of observation, level of collinearity and percentage of outliers used. However, when outliers occurred in only single direction (y-direction), the WRMM estimator is the most superior among the robust ridge regression estimators, by producing the least variance. In conclusion, the robust ridge regression is the best alternative as compared to robust and conventional least squares estimators when dealing with simultaneous presence of multicollinearity and outliers.

  2. Comparison of Methods to Trace Multiple Subskills: Is LR-DBN Best?

    Xu, Yanbo; Mostow, Jack

    2012-01-01

    A long-standing challenge for knowledge tracing is how to update estimates of multiple subskills that underlie a single observable step. We characterize approaches to this problem by how they model knowledge tracing, fit its parameters, predict performance, and update subskill estimates. Previous methods allocated blame or credit among subskills…

  3. Child Sexual Abuse and Adult Romantic Adjustment: Comparison of Single- and Multiple-Indicator Measures

    Godbout, Natacha; Sabourin, Stephane; Lussier, Yvan

    2009-01-01

    This study compared the usefulness of single- and multiple-indicator strategies in a model examining the role of child sexual abuse (CSA) to predict later marital satisfaction through attachment and psychological distress. The sample included 1,092 women and men from a nonclinical population in cohabiting or marital relationships. The single-item…

  4. Ethnic Comparisons in HIV Testing Attitudes, HIV Testing, and Predictors of HIV Testing Among Black and White College Students.

    Moore, Melanie P; Javier, Sarah J; Abrams, Jasmine A; McGann, Amanda Wattenmaker; Belgrave, Faye Z

    2017-08-01

    This study's primary aim was to examine ethnic differences in predictors of HIV testing among Black and White college students. We also examined ethnic differences in sexual risk behaviors and attitudes toward the importance of HIV testing. An analytic sample of 126 Black and 617 White undergraduatestudents aged 18-24 were analyzed for a subset of responses on the American College Health Association-National College Health Assessment II (ACHA-NCHA II) (2012) pertaining to HIV testing, attitudes about the importance of HIV testing, and sexual risk behaviors. Predictors of HIV testing behavior were analyzed using logistic regression. t tests and chi-square tests were performed to access differences in HIV test history, testing attitudes, and sexual risk behaviors. Black students had more positive attitudes toward testing and were more likely to have been tested for HIV compared to White students. A greater number of sexual partners and more positive HIV testing attitudes were significant predictors of HIV testing among White students, whereas relationship status predicted testing among Black students. Older age and history of ever having sex were significant predictors of HIV testing for both groups. There were no significant differences between groups in number of sexual partners or self-reports in history of sexual experience (oral, vaginal, or anal). Factors that influence HIV testing may differ across racial/ethnic groups. Findings support the need to consider racial/ethnic differences in predictors of HIV testing during the development and tailoring of HIV testing prevention initiatives targeting college students.

  5. Cascade Distillation Subsystem Development: Early Results from the Exploration Life Support Distillation Technology Comparison Test

    Callahan, Michael R.; Patel, Vipul; Pickering, Karen D.

    2010-01-01

    In 2009, the Cascade Distillation Subsystem (CDS) wastewater processor (Honeywell International, Torrance, California) was assessed in the National Aeronautics and Space Administration (NASA) Exploration Life Support (ELS) distillation comparison test. The purpose of the test was to collect data to support down-selection and development of a primary distillation technology for application in a lunar outpost water recovery system. The CDS portion of the comparison test was conducted between May 6 and August 19, 2009. The system was challenged with two pretreated test solutions, each intended to represent a feasible wastewater generated in a surface habitat. The 30-day equivalent wastewater loading volume for a crew of four was intended to be processed for each wastewater solution. Test Solution 1 consisted of a mixed stream containing human-generated urine and humidity condensate. Test Solution 2 contained the addition of human-generated hygiene wastewater to the solution 1 waste stream components. Approximately 1500 kg of total wastewater was processed through the CDS during testing. Respective recoveries per solution were 93.4 +/- 0.7 and 90.3 +/- 0.5 percent. The average specific energy of the system during testing was calculated to be less than 120 W-hr/kg. The following paper provides detailed information and data on the performance of the CDS as challenged per the ELS distillation comparison test.

  6. Measuring University students' understanding of the greenhouse effect - a comparison of multiple-choice, short answer and concept sketch assessment tools with respect to students' mental models

    Gold, A. U.; Harris, S. E.

    2013-12-01

    The greenhouse effect comes up in most discussions about climate and is a key concept related to climate change. Existing studies have shown that students and adults alike lack a detailed understanding of this important concept or might hold misconceptions. We studied the effectiveness of different interventions on University-level students' understanding of the greenhouse effect. Introductory level science students were tested for their pre-knowledge of the greenhouse effect using validated multiple-choice questions, short answers and concept sketches. All students participated in a common lesson about the greenhouse effect and were then randomly assigned to one of two lab groups. One group explored an existing simulation about the greenhouse effect (PhET-lesson) and the other group worked with absorption spectra of different greenhouse gases (Data-lesson) to deepen the understanding of the greenhouse effect. All students completed the same assessment including multiple choice, short answers and concept sketches after participation in their lab lesson. 164 students completed all the assessments, 76 completed the PhET lesson and 77 completed the data lesson. 11 students missed the contrasting lesson. In this presentation we show the comparison between the multiple-choice questions, short answer questions and the concept sketches of students. We explore how well each of these assessment types represents student's knowledge. We also identify items that are indicators of the level of understanding of the greenhouse effect as measured in correspondence of student answers to an expert mental model and expert responses. Preliminary data analysis shows that student who produce concept sketch drawings that come close to expert drawings also choose correct multiple-choice answers. However, correct multiple-choice answers are not necessarily an indicator that a student produces an expert-like correlating concept sketch items. Multiple-choice questions that require detailed

  7. Young children’s learning of relational categories:multiple comparisons and their cognitive constraints

    Jean-Pierre eThibaut

    2015-05-01

    Full Text Available Relational categories are notoriously difficult to learn because they are not defined by intrinsic stable properties. We studied the impact of comparisons on relational concept learning with a novel word learning task in 42-month-old children. Capitalizing on Gentner et al. (2011, two, three or four pairs of stimuli were introduced with a novel relational word. In a given trial, the set of pairs was composed of either close or far pairs (e.g., close pair: knife1-watermelon, knife2-orange, knife3-slice of bread and knife4-meat; far pair: ax-evergreen tree, saw-log, cutter-cardboard and knife-slice of bread, for the cutter for relation. Close pairs (2 vs. 3 vs. 4 pairs led to random generalizations whereas comparisons with far pairs gave the expected relational generalization. The 3 pair case gave the best results. It is argued that far pairs promote deeper comparisons than close pairs. As shown by a control experiment, this was the case only when far pairs display well known associations.

  8. Multiple sample setup for testing the hydrothermal stability of adsorbents in thermal energy storage applications

    Fischer, Fabian; Laevemann, Eberhard

    2015-01-01

    Thermal energy storage based on adsorption and desorption of water on an adsorbent can achieve high energy storage densities. Many adsorbents lose adsorption capacity when operated under unfavourable hydrothermal conditions during adsorption and desorption. The stability of an adsorbent against stressing hydrothermal conditions is a key issue for its usability in adsorption thermal energy storage. We built an experimental setup that simultaneously controls the hydrothermal conditions of 16 samples arranged in a matrix of four temperatures and four water vapour pressures. This setup allows the testing of potential adsorbents between temperatures of 50 °C and 350 °C and water vapour pressures of up to 32 kPa. A measurement procedure that allows the detection of the hydrothermal stability of an adsorbent after defined time spans has been designed. We verified the functionality of the multiple sample measurements with a microporous adsorbent, a zeolite NaMSX. The hydrothermal stability of this zeolite is tested by water uptake measurements. A standard deviation lower than 1% of the 16 samples for detecting the hydrothermal stability enables setting different conditions in each sample cell. Further, we compared the water uptake measurements by measuring their adsorption isotherms with the volumetric device BELSORP Aqua 3 from Bel Japan. (paper)

  9. Abbreviation modalities of nitrogen multiple-breath washout tests in school children with obstructed lung disease

    Green, Kent; Ejlertsen, Jacob S; Madsen, Astrid

    2016-01-01

    , the lung clearance index, calculated as lung volume turnovers required to reach 2.5% of the starting N2 concentration (LCI2.5 ). METHODS: Cross-sectional study of triplicate N2 MBW measurements obtained in cystic fibrosis (CF) patients (N = 60), primary ciliary dyskinesia (PCD) patients (N = 28......RATIONALE: Nitrogen multiple-breath washout (N2 MBW) is a promising tool for assessing early lung damage in children with chronic obstructive pulmonary disease, but it can be a time-consuming procedure. We compared alternative test-shortening endpoints with the most commonly reported N2 MBW outcome...... MBW runs in each session. N2 MBW endpoints were analyzed as z-scores calculated from healthy controls. RESULTS: In PCD, Cn@TO6 and LCI2.5 exhibited similar values (mean [95%CI] difference: 0.33 [-0.24; 0.90] z-scores), reducing the test duration by one-third (5.4 min; 95%CI: 4.0; 6.8). All other...

  10. Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical Statement.

    Robinson, Paul D; Latzin, Philipp; Ramsey, Kathryn A; Stanojevic, Sanja; Aurora, Paul; Davis, Stephanie D; Gappa, Monika; Hall, Graham L; Horsley, Alex; Jensen, Renee; Lum, Sooky; Milla, Carlos; Nielsen, Kim G; Pittman, Jessica E; Rosenfeld, Margaret; Singer, Florian; Subbarao, Padmaja; Gustafsson, Per M; Ratjen, Felix

    2018-03-01

    Obstructive airway disease is nonuniformly distributed throughout the bronchial tree, although the extent to which this occurs can vary among conditions. The multiple-breath washout (MBW) test offers important insights into pediatric lung disease, not available through spirometry or resistance measurements. The European Respiratory Society/American Thoracic Society inert gas washout consensus statement led to the emergence of validated commercial equipment for the age group 6 years and above; specific recommendations for preschool children were beyond the scope of the document. Subsequently, the focus has shifted to MBW applications within preschool subjects (aged 2-6 yr), where a "window of opportunity" exists for early diagnosis of obstructive lung disease and intervention. This preschool-specific technical standards document was developed by an international group of experts, with expertise in both custom-built and commercial MBW equipment. A comprehensive review of published evidence was performed. Recommendations were devised across areas that place specific age-related demands on MBW systems. Citing evidence where available in the literature, recommendations are made regarding procedures that should be used to achieve robust MBW results in the preschool age range. The present work also highlights the important unanswered questions that need to be addressed in future work. Consensus recommendations are outlined to direct interested groups of manufacturers, researchers, and clinicians in preschool device design, test performance, and data analysis for the MBW technique.

  11. The test beamline of the European Spallation Source – Instrumentation development and wavelength frame multiplication

    Woracek, R.; Hofmann, T.; Bulat, M.; Sales, M.; Habicht, K.; Andersen, K.; Strobl, M.

    2016-01-01

    The European Spallation Source (ESS), scheduled to start operation in 2020, is aiming to deliver the most intense neutron beams for experimental research of any facility worldwide. Its long pulse time structure implies significant differences for instrumentation compared to other spallation sources which, in contrast, are all providing short neutron pulses. In order to enable the development of methods and technology adapted to this novel type of source well in advance of the first instruments being constructed at ESS, a test beamline (TBL) was designed and built at the BER II research reactor at Helmholtz-Zentrum Berlin (HZB). Operating the TBL shall provide valuable experience in order to allow for a smooth start of operations at ESS. The beamline is capable of mimicking the ESS pulse structure by a double chopper system and provides variable wavelength resolution as low as 0.5% over a wide wavelength band between 1.6 Å and 10 Å by a dedicated wavelength frame multiplication (WFM) chopper system. WFM is proposed for several ESS instruments to allow for flexible time-of-flight resolution. Hence, ESS will benefit from the TBL which offers unique possibilities for testing methods and components. This article describes the main capabilities of the instrument, its performance as experimentally verified during the commissioning, and its relevance to currently starting ESS instrumentation projects.

  12. The utility of a 5(th) nap in multiple sleep latency test.

    Muza, Rexford; Lykouras, Dimosthenis; Rees, Kate

    2016-02-01

    This is the first study that aimed to look specifically at the utility of the 5(th) nap in the multiple sleep latency test (MSLT), a test used to assist in the diagnosis of narcolepsy. Data was retrospectively collected from the Sleep Disorders Centre of a Tertiary Hospital on patients that had a 5(th) nap during their MSLT from the 08(th) November 2011 to 12(th) November 2014. Fifty-three patients had a 5(th) nap performed out of 378 MSLT studies. In 16% of cases a diagnosis of narcolepsy was given directly due to the inclusion of the 5(th) nap on the MSLT. Here a 5(th) nap allowed diagnostic criteria of mean sleep latency 2 SOREMPS to be met. In 53% of cases the mean sleep latency increased due to 5(th) nap inclusion; the mean sleep latency of the first four naps was 5.6 vs. 6.7 after inclusion of the 5(th) nap. The 5(th) nap is not often performed within the MSLT studies. Our study shows that only a few patients may benefit from a 5(th) nap opportunity which also led to increase of the mean sleep latency at the expense of extra time, cost, labour and increased patient anxiety.

  13. Identification of Misconceptions through Multiple Choice Tasks at Municipal Chemistry Competition Test

    Dušica D Milenković

    2016-01-01

    Full Text Available In this paper, the level of conceptual understanding of chemical contents among seventh grade students who participated in the municipal Chemistry competition in Novi Sad, Serbia, in 2013 have been examined. Tests for the municipal chemistry competition were used as a measuring instrument, wherein only multiple choice tasks were considered and analyzed. Determination of the level of conceptual understanding of the tested chemical contents was based on the calculation of the frequency of choosing the correct answers. Thereby, identification of areas of satisfactory conceptual understanding, areas of roughly adequate performance, areas of inadequate performance, and areas of quite inadequate performance have been conducted. On the other hand, the analysis of misconceptions was based on the analysis of distractors. The results showed that satisfactory level of conceptual understanding and roughly adequate performance characterize majority of contents, which was expected since only the best students who took part in the contest were surveyed. However, this analysis identified a large number of misunderstandings, as well. In most of the cases, these misconceptions were related to the inability to distinguish elements, compounds, homogeneous and heterogeneous mixtures. Besides, it is shown that students are not familiar with crystal structure of the diamond, and with metric prefixes. The obtained results indicate insufficient visualization of the submicroscopic level in school textbooks, the imprecise use of chemical language by teachers and imprecise use of language in chemistry textbooks.

  14. Decision making under internal uncertainty: the case of multiple-choice tests with different scoring rules.

    Bereby-Meyer, Yoella; Meyer, Joachim; Budescu, David V

    2003-02-01

    This paper assesses framing effects on decision making with internal uncertainty, i.e., partial knowledge, by focusing on examinees' behavior in multiple-choice (MC) tests with different scoring rules. In two experiments participants answered a general-knowledge MC test that consisted of 34 solvable and 6 unsolvable items. Experiment 1 studied two scoring rules involving Positive (only gains) and Negative (only losses) scores. Although answering all items was the dominating strategy for both rules, the results revealed a greater tendency to answer under the Negative scoring rule. These results are in line with the predictions derived from Prospect Theory (PT) [Econometrica 47 (1979) 263]. The second experiment studied two scoring rules, which allowed respondents to exhibit partial knowledge. Under the Inclusion-scoring rule the respondents mark all answers that could be correct, and under the Exclusion-scoring rule they exclude all answers that might be incorrect. As predicted by PT, respondents took more risks under the Inclusion rule than under the Exclusion rule. The results illustrate that the basic process that underlies choice behavior under internal uncertainty and especially the effect of framing is similar to the process of choice under external uncertainty and can be described quite accurately by PT. Copyright 2002 Elsevier Science B.V.

  15. The test beamline of the European Spallation Source – Instrumentation development and wavelength frame multiplication

    Woracek, R., E-mail: robin.woracek@esss.se [European Spallation Source ESS ERIC, P.O. Box 176, SE-22100 Lund (Sweden); Hofmann, T.; Bulat, M. [Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner Platz 1, 14109 Berlin (Germany); Sales, M. [Technical University of Denmark, Fysikvej, 2800 Kgs. Lyngby (Denmark); Habicht, K. [Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner Platz 1, 14109 Berlin (Germany); Andersen, K. [European Spallation Source ESS ERIC, P.O. Box 176, SE-22100 Lund (Sweden); Strobl, M. [European Spallation Source ESS ERIC, P.O. Box 176, SE-22100 Lund (Sweden); Technical University of Denmark, Fysikvej, 2800 Kgs. Lyngby (Denmark)

    2016-12-11

    The European Spallation Source (ESS), scheduled to start operation in 2020, is aiming to deliver the most intense neutron beams for experimental research of any facility worldwide. Its long pulse time structure implies significant differences for instrumentation compared to other spallation sources which, in contrast, are all providing short neutron pulses. In order to enable the development of methods and technology adapted to this novel type of source well in advance of the first instruments being constructed at ESS, a test beamline (TBL) was designed and built at the BER II research reactor at Helmholtz-Zentrum Berlin (HZB). Operating the TBL shall provide valuable experience in order to allow for a smooth start of operations at ESS. The beamline is capable of mimicking the ESS pulse structure by a double chopper system and provides variable wavelength resolution as low as 0.5% over a wide wavelength band between 1.6 Å and 10 Å by a dedicated wavelength frame multiplication (WFM) chopper system. WFM is proposed for several ESS instruments to allow for flexible time-of-flight resolution. Hence, ESS will benefit from the TBL which offers unique possibilities for testing methods and components. This article describes the main capabilities of the instrument, its performance as experimentally verified during the commissioning, and its relevance to currently starting ESS instrumentation projects.

  16. Spatial and visuospatial working memory tests predict performance in classic multiple-object tracking in young adults, but nonspatial measures of the executive do not.

    Trick, Lana M; Mutreja, Rachna; Hunt, Kelly

    2012-02-01

    An individual-differences approach was used to investigate the roles of visuospatial working memory and the executive in multiple-object tracking. The Corsi Blocks and Visual Patterns Tests were used to assess visuospatial working memory. Two relatively nonspatial measures of the executive were used: operation span (OSPAN) and reading span (RSPAN). For purposes of comparison, the digit span test was also included (a measure not expected to correlate with tracking). The tests predicted substantial amounts of variance (R (2) = .33), and the visuospatial measures accounted for the majority (R (2) = .30), with each making a significant contribution. Although the executive measures correlated with each other, the RSPAN did not correlate with tracking. The correlation between OSPAN and tracking was similar in magnitude to that between digit span and tracking (p < .05 for both), and when regression was used to partial out shared variance between the two tests, the remaining variance predicted by the OSPAN was minimal (sr ( 2 ) = .029). When measures of spatial memory were included in the regression, the unique variance predicted by the OSPAN became negligible (sr ( 2 ) = .000004). This suggests that the executive, as measured by tests such as the OSPAN, plays little role in explaining individual differences in multiple-object tracking.

  17. Diagnostic accuracy of full-body linear X-ray scanning in multiple trauma patients in comparison to computed tomography

    Joeres, A.P.W.; Heverhagen, J.T.; Bonel, H. [Inselspital - University Hospital Bern (Switzerland). Univ. Inst. of Diagnostic, Interventional and Pediatric Radiology; Exadaktylos, A. [Inselspital - University Hospital Bern (Switzerland). Dept. of Emergency Medicine; Klink, T. [Inselspital - University Hospital Bern (Switzerland). Univ. Inst. of Diagnostic, Interventional and Pediatric Radiology; Wuerzburg Univ. (Germany). Inst. of Diagnostic and Interventional Radiology

    2016-02-15

    The purpose of this study was to evaluate the diagnostic accuracy of full-body linear X-ray scanning (LS) in multiple trauma patients in comparison to 128-multislice computed tomography (MSCT). 106 multiple trauma patients (female: 33; male: 73) were retrospectively included in this study. All patients underwent LS of the whole body, including extremities, and MSCT covering the neck, thorax, abdomen, and pelvis. The diagnostic accuracy of LS for the detection of fractures of the truncal skeleton and pneumothoraces was evaluated in comparison to MSCT by two observers in consensus. Extremity fractures detected by LS were documented. The overall sensitivity of LS was 49.2%, the specificity was 93.3%, the positive predictive value was 91%, and the negative predictive value was 57.5%. The overall sensitivity for vertebral fractures was 16.7%, and the specificity was 100%. The sensitivity was 48.7% and the specificity 98.2% for all other fractures. Pneumothoraces were detected in 12 patients by CT, but not by LS.40 extremity fractures were detected by LS, of which 4 fractures were dislocated, and 2 were fully covered by MSCT. The diagnostic accuracy of LS is limited in the evaluation of acute trauma of the truncal skeleton. LS allows fast whole-body X-ray imaging, and may be valuable for detecting extremity fractures in trauma patients in addition to MSCT.

  18. Comparison of a New and Rapid Method: Brucella Coombs Gel Test With Other Diagnostic Tests.

    Kalem, Fatma; Ergün, Ayşe Gül; Durmaz, Süleyman; Doğan, Metin; Ertuğrul, Ömür; Gündem, Seval

    2016-09-01

    The aim of this study was to detect reliability of Brucella Coombs gel test (BCGT) by comparing with with ELISA (IgG + IgM), Standard agglutination test, and Brucella immunocapture agglutination methods in serological diagnosis of brucellosis. Brucella Coombs gel test (BCGT), Brucella ELISA (IgG + IgM), Standard agglutination test, and Brucella immunocapture agglutination tests of 78 patients with presumptive diagnosis of brucellosis which were sent to Microbiology Laboratory of Konya Numune Hospital from various regions of Konya were studied. Of 78 patients with ELISA IgG and IgM, STA, BICA and BCGT; 26, 21, 10, 12 and 12 were positive. When compared with BICA, the sensitivity and specifity of BCGT were 100% and 100%, respectively. According to results BCGT can be used as a diagnostic test in routine laboratories after more comprehensive studies in control groups and patients. © 2016 Wiley Periodicals, Inc.

  19. Comparison of static conformal field with multiple noncoplanar arc techniques for stereotactic radiosurgery or stereotactic radiotherapy

    Hamilton, Russell J.; Kuchnir, Franca T.; Sweeney, Patrick; Rubin, Steven J.; Dujovny, Manuel; Pelizzari, Charles A.; Chen, George T. Y.

    1995-01-01

    Purpose: Compare the use of static conformal fields with the use of multiple noncoplanar arcs for stereotactic radiosurgery or stereotactic radiotherapy treatment of intracranial lesions. Evaluate the efficacy of these treatment techniques to deliver dose distributions comparable to those considered acceptable in current radiotherapy practice. Methods and Materials: A previously treated radiosurgery case of a patient presenting with an irregularly shaped intracranial lesion was selected. Using a three-dimensional (3D) treatment-planning system, treatment plans using a single isocenter multiple noncoplanar arc technique and multiple noncoplanar conformal static fields were generated. Isodose distributions and dose volume histograms (DVHs) were computed for each treatment plan. We required that the 80% (of maximum dose) isodose surface enclose the target volume for all treatment plans. The prescription isodose was set equal to the minimum target isodose. The DVHs were analyzed to evaluate and compare the different treatment plans. Results: The dose distribution in the target volume becomes more uniform as the number of conformal fields increases. The volume of normal tissue receiving low doses (> 10% of prescription isodose) increases as the number of static fields increases. The single isocenter multiple arc plan treats the greatest volume of normal tissue to low doses, approximately 1.6 times more volume than that treated by four static fields. The volume of normal tissue receiving high (> 90% of prescription isodose) and intermediate (> 50% of prescription isodose) doses decreases by 29 and 22%, respectively, as the number of static fields is increased from four to eight. Increasing the number of static fields to 12 only further reduces the high and intermediate dose volumes by 10 and 6%, respectively. The volume receiving the prescription dose is more than 3.5 times larger than the target volume for all treatment plans. Conclusions: Use of a multiple noncoplanar

  20. Valx: A System for Extracting and Structuring Numeric Lab Test Comparison Statements from Text.

    Hao, Tianyong; Liu, Hongfang; Weng, Chunhua

    2016-05-17

    To develop an automated method for extracting and structuring numeric lab test comparison statements from text and evaluate the method using clinical trial eligibility criteria text. Leveraging semantic knowledge from the Unified Medical Language System (UMLS) and domain knowledge acquired from the Internet, Valx takes seven steps to extract and normalize numeric lab test expressions: 1) text preprocessing, 2) numeric, unit, and comparison operator extraction, 3) variable identification using hybrid knowledge, 4) variable - numeric association, 5) context-based association filtering, 6) measurement unit normalization, and 7) heuristic rule-based comparison statements verification. Our reference standard was the consensus-based annotation among three raters for all comparison statements for two variables, i.e., HbA1c and glucose, identified from all of Type 1 and Type 2 diabetes trials in ClinicalTrials.gov. The precision, recall, and F-measure for structuring HbA1c comparison statements were 99.6%, 98.1%, 98.8% for Type 1 diabetes trials, and 98.8%, 96.9%, 97.8% for Type 2 diabetes trials, respectively. The precision, recall, and F-measure for structuring glucose comparison statements were 97.3%, 94.8%, 96.1% for Type 1 diabetes trials, and 92.3%, 92.3%, 92.3% for Type 2 diabetes trials, respectively. Valx is effective at extracting and structuring free-text lab test comparison statements in clinical trial summaries. Future studies are warranted to test its generalizability beyond eligibility criteria text. The open-source Valx enables its further evaluation and continued improvement among the collaborative scientific community.

  1. Comparison of test and earthquake response modeling of a nuclear power plant containment building

    Srinivasan, M.G.; Kot, C.A.; Hsieh, B.J.

    1985-01-01

    The reactor building of a BWR plant was subjected to dynamic testing, a minor earthquake, and a strong earthquake at different times. Analytical models simulating each of these events were devised by previous investigators. A comparison of the characteristics of these models is made in this paper. The different modeling assumptions involved in the different simulation analyses restrict the validity of the models for general use and also narrow the comparison down to only a few modes. The dynamic tests successfully identified the first mode of the soil-structure system.

  2. Comparison of test and earthquake response modeling of a nuclear power plant containment building

    Srinivasan, M.G.; Kot, C.A.; Hsieh, B.J.

    1985-01-01

    The reactor building of a BWR plant was subjected to dynamic testing, a minor earthquake, and a strong earthquake at different times. Analytical models simulating each of these events were devised by previous investigators. A comparison of the characteristics of these models is made in this paper. The different modeling assumptions involved in the different simulation analyses restrict the validity of the models for general use and also narrow the comparison down to only a few modes. The dynamic tests successfully identified the first mode of the soil-structure system

  3. Comparison of ASTECV1.3.2 and ASTECV2 results for QUENCH 12 test

    Stefanova, A.

    2010-01-01

    This paper presents a comparison of QUENCH 12 test calculated results with ASTECv1.3R2 and ASTECv2 computer codes. The test was performed to investigate the behavior of VVER fuel assemblies. This investigation is a part of the 6th and 7th framework programs of the EC supported ISTC program. The test facility is located at Forschungszentrum in Karlsruhe. The structure of the test facility allows experimental studies under transient and accident conditions. The ASTEC1.3R2 and ASTECv2 computer codes have been used to simulate the investigated test. The base line input model for ASTEC was provided from Forschungszentrum, Karlsruhe. During the preparation of QUENCH - 12 experiment, the input deck was adapted to new initial and boundary conditions. The comparison show good agreement between measured data and ASTEC calculated results. (author)

  4. A Monte Carlo Study on Multiple Output Stochastic Frontiers: Comparison of Two Approaches

    Henningsen, Geraldine; Henningsen, Arne; Jensen, Uwe

    , dividing all other output quantities by the selected output quantity, and using these ratios as regressors (OD). Another approach is the stochastic ray production frontier (SR) which transforms the output quantities into their Euclidean distance as the dependent variable and their polar coordinates......In the estimation of multiple output technologies in a primal approach, the main question is how to handle the multiple outputs. Often an output distance function is used, where the classical approach is to exploit its homogeneity property by selecting one output quantity as the dependent variable...... of both specifications for the case of a Translog output distance function with respect to different common statistical problems as well as problems arising as a consequence of zero values in the output quantities. Although, our results partly show clear reactions to statistical misspecifications...

  5. Comparison effectiveness of Dialectic Behavioral Therapy and Behavior Cognitive Therapy on Depression in the Multiple sclerosis

    Narges Zamani; Mehran Farhadi; Hosein Jenaabadi

    2017-01-01

    Balsimelli S, Mendes MF, Bertolucci PH, Tilbery CP. Attention impairment associated with relapsing-remitting multiple sclerosis patients with mild incapacity. Arq Neuropsiquiatr 2007;65(2A):262-7. Zamani N, Ahmadi V, Ataie Moghanloo V, Mirshekar S. Comparing the effectiveness of two therapeutic methods of dialectical behavior therapy and cognitive behavior therapy on the improvement of impulsive behavior in the patients suffering  from major depressive disorder (MDD) showing a t...

  6. Bone marrow scintigraphy with antigranulocyte antibody in multiple myeloma: comparison with simple radiography and bone scintigraphy

    Kim, Dong Hwan; Lee, Jae Tae; Baek, Jin Ho

    1998-01-01

    Simple X-ray study and bone scan have limitations for early diagnosis of bone or bone marrow lesions in multiple myeloma. The purpose of this study was to evaluate the diagnostic usefulness of bone marrow immunoscintigraphy using anti-granulocyte monoclonal antibody for the evaluation of bone involvement in multiple myeloma. In 22 patients (Male: 15, Female: 7) with multiple myeloma, we performed whole-body immunoscintigraphy using 99m Tc-labelled antigranulocyte antibody (BW 250/183, Scintimum Granulozyt R CIS, France) and compared the findings with those of simple bone radiography and 99m Tc-MDP bone scan. Abnormal findings in bone marrow scintigraphy were considered to be present in case of expansion of peripheral bone marrow or focal photon defect in axial bones. Marrow expansion was noted in 15 of 22 patients (68%). Focal photon defects were found in 18 patients (82%). While one (33%) of 3 patients with Stage II disease showed focal defects in bone marrow scan, abnormal focal defects were observed in 17 of 19 (90%) patients with Stage III. Among 124 focal abnormal sites which were observed in bone marrow scan, bone scan or simple bone radiography, bone marrow scan detected 92 sites (74%), whereas 82 sites (66%) were observed in simple bone radiogrpahy (58 sites, 47%) or bone scan (40 sites, 32%). Fifty-one(41%) out of 124 bone lesions were detected by bone marrow scan only, and located mostly in thoracolumbar spine. Bone marrow scan using 99m Tc-labelled antigranulocyte antibody seems to be a more sensitive procedure for the detection of pathologic bone lesions than simple bone X-ray or bone scan in patients with multiple myeloma

  7. Comparison of peripheral nerve stimulator versus ultrasonography guided axillary block using multiple injection technique.

    Kumar, Alok; Sharma, Dk; Sibi, Maj E; Datta, Barun; Gogoi, Biraj

    2014-01-01

    The established methods of nerve location were based on either proper motor response on nerve stimulation (NS) or ultrasound guidance. In this prospective, randomised, observer-blinded study, we compared ultrasound guidance with NS for axillary brachial plexus block using 0.5% bupivacaine with the multiple injection techniques. A total of 120 patients receiving axillary brachial plexus block with 0.5% bupivacaine, using a multiple injection technique, were randomly allocated to receive either NS (group NS, n = 60), or ultrasound guidance (group US, n = 60) for nerve location. A blinded observer recorded the onset of sensory and motor blocks, skin punctures, needle redirections, procedure-related pain and patient satisfaction. The median (range) number of skin punctures were 2 (2-4) in group US and 3 (2-5) in group NS (P =0.27). Insufficient block was observed in three patient (5%) of group US and four patients (6.67%) of group NS (P > =0.35). Patient acceptance was similarly good in the two groups. Multiple injection axillary blocks with ultrasound guidance provided similar success rates and comparable incidence of complications as compared with NS guidance with 20 ml 0.5% bupivacaine.

  8. Comparison of drug treatment histories of single and multiple drug abusers in detox.

    Greberman, S B; Jasinski, D

    2001-01-01

    This study was undertaken to determine differences in previous treatment patterns in individuals currently using different numbers of substances. Medical records of 1198 inpatient detoxification (detox) admissions were analyzed. Numbers of past admissions to completed detox, methadone, or other types of drug abuse treatment were totaled and ranked to determine most frequent type. Within gender, treatment histories of single and multiple drug abusers usually do not differ. The one exception is male multiple drug abusers ages 26-30, who show increased admissions. Possible explanations are that men do not seek treatment before developing medical complications of addiction or until external factors influence admission. There were differences in treatment histories between genders in multiple drug abusers only. Before age 30, women reported increased treatment of certain types. Possible explanations are that treatment priority is given to women who are, or may be, pregnant. Also, younger men may not enter or complete treatment. Previous treatment history may influence many behaviors. The results of this study delineate several valuable indicators for assessing past history.

  9. Comparison of peripheral nerve stimulator versus ultrasonography guided axillary block using multiple injection technique

    Alok Kumar

    2014-01-01

    Full Text Available Background: The established methods of nerve location were based on either proper motor response on nerve stimulation (NS or ultrasound guidance. In this prospective, randomised, observer-blinded study, we compared ultrasound guidance with NS for axillary brachial plexus block using 0.5% bupivacaine with the multiple injection techniques. Methods : A total of 120 patients receiving axillary brachial plexus block with 0.5% bupivacaine, using a multiple injection technique, were randomly allocated to receive either NS (group NS, n = 60, or ultrasound guidance (group US, n = 60 for nerve location. A blinded observer recorded the onset of sensory and motor blocks, skin punctures, needle redirections, procedure-related pain and patient satisfaction. Results: The median (range number of skin punctures were 2 (2-4 in group US and 3 (2-5 in group NS (P =0.27. Insufficient block was observed in three patient (5% of group US and four patients (6.67% of group NS (P > =0.35. Patient acceptance was similarly good in the two groups. Conclusion: Multiple injection axillary blocks with ultrasound guidance provided similar success rates and comparable incidence of complications as compared with NS guidance with 20 ml 0.5% bupivacaine.

  10. Diagnostic utility of the glucagon stimulation test in comparison to the insulin tolerance test in patients following pituitary surgery

    Berg, Christian; Meinel, Timo; Lahner, Harald

    2009-01-01

    OBJECTIVE: The glucagon stimulation test (GST) like the insulin tolerance test (ITT) stimulates both ACTH and GH secretion. However, there are limited data with modern assays on sensitivity and specificity for GST in comparison to ITT. The aim of this study was to evaluate the diagnostic utility......). Receiver-operating characteristic (ROC) analysis was performed to identify the thresholds for GST. RESULTS: In ITT, 18/49 cases were classified as AI. ROC analysis revealed a peak cortisol value >599 nmol/l in GST for adrenal sufficiency with 100% specificity and 32% sensitivity, and a peak cortisol

  11. A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies

    Lange, C; Lyon, H; DeMeo, D; Raby, B; Silverman, EK; Weiss, ST

    2003-01-01

    We introduce a new powerful nonparametric testing strategy for family-based association studies in which multiple quantitative traits are recorded and the phenotype with the strongest genetic component is not known prior to the analysis. In the first stage, using a population-based test based on the

  12. LEGO plot for simultaneous application of multiple quality requirements during trueness verification of quantitative laboratory tests.

    Park, Hae-il; Chae, Hyojin; Kim, Myungshin; Lee, Jehoon; Kim, Yonggoo

    2014-03-01

    We developed a two-dimensional plot for viewing trueness that takes into account potential shift and variable quality requirements to verify trueness using certified reference material (CRM). Glucose, total cholesterol (TC), and creatinine levels were determined by two kinds of assay in two levels of a CRM. Available quality requirements were collected, codified, and sorted in an ascending order in the plot's header row. Centering on the mean of measured values from CRM, the "mean ± US CLIA '88 allowable total error" was located in the header of the leftmost and rightmost columns. Twenty points were created in intervening columns as potential shifts. Uncertainties were calculated according to regression between certified values and uncertainties of CRM, and positioned in the corresponding columns. Cells were assigned different colors where column and row intersected based on comparison of the 95% confidence interval of the percentage bias with each quality requirement. A glucose assay failed to meet the highest quality criteria, for which shift of +0.13-0.14 mmol/l was required. A TC assay met the quality requirement and a shift of ±0.03 mmol/l was tolerable. A creatinine assay also met the quality requirement but any shift was not tolerable. The plot provides a systematic view of the trueness of quantitative laboratory tests. © 2014 Wiley Periodicals, Inc.

  13. "None of the above" as a correct and incorrect alternative on a multiple-choice test: implications for the testing effect.

    Odegard, Timothy N; Koen, Joshua D

    2007-11-01

    Both positive and negative testing effects have been demonstrated with a variety of materials and paradigms (Roediger & Karpicke, 2006b). The present series of experiments replicate and extend the research of Roediger and Marsh (2005) with the addition of a "none-of-the-above" response option. Participants (n=32 in both experiments) read a set of passages, took an initial multiple-choice test, completed a filler task, and then completed a final cued-recall test (Experiment 1) or multiple-choice test (Experiment 2). Questions were manipulated on the initial multiple-choice test by adding a "none-of-the-above" response alternative (choice "E") that was incorrect ("E" Incorrect) or correct ("E" Correct). The results from both experiments demonstrated that the positive testing effect was negated when the "none-of-the-above" alternative was the correct response on the initial multiple-choice test, but was still present when the "none-of-the-above" alternative was an incorrect response.

  14. The Comparison Study of Contralateral Transient Evoked Otoacoustic Emission (TEOAE Suppression in Normal Hearing Subjects and Multiple Sclerosis Patients

    KH Mohamadkhani

    2007-01-01

    Full Text Available ABSTRACT: Introduction & Objective: A common auditory complaint of multiple sclerosis patients, is misunderstanding speech in the presence of background noise. Evidence from animal and human studies has suggested that the medial olivocochlear bundle may play an important role in hearing noise. The medial olivocochlear bundle function can be evaluated by the suppression effect of transient otoacoustic emission in response to contralateral acoustic stimulation. The present study was conducted to investigate the suppression effect of transient otoacoustic emission in multiple sclerosis patients. Materials & Methods: This analytical case-control study was conducted on 34 multiple sclerosis patients (24 female, 10 male, aged 20-50 years and 34 controls matched for age and gender in Faculty of Rehabilitation, Tehran University of Medical Sciences in 2006. All cases were selected in simple random manner. The suppression effect of transient otoacoustic emission was evaluated by comparing the transient otoacoustic emission levels with and without contralateral acoustic stimulation. Data were analyzed using SPSS software and independent T- test. Results:There was no significant difference in transient otoacoustic emission levels of two groups, but a significantly reduced suppression effect of transient otoacoustic emission was found in multiple sclerosis patients, in compare with the controls. Conclusion: Outer hair cells activity in multiple sclerosis patients was normal but these patients presented low activity of the medial olivocochlear bundle system which could affect their ability to hear in the presence of background noise.

  15. Misuse of multiple comparison tests and underuse of contrast procedures in aquaculture publications

    Yossa, R.; Verdegem, M.C.J.

    2015-01-01

    In aquaculture research, independent variables are qualitative (with or without a structure), quantitative, or factorial combinations. A qualitative independent variable is a variable that has unquantifiable, nominal variants (levels), which represent different categories such as the fish gender.

  16. A Studentized Permutation Test for the Comparison of Spatial Point Patterns

    Hahn, Ute

    of empirical K-functions are compared by a permutation test using a studentized test statistic. The proposed test performs convincingly in terms of empirical level and power in a simulation study, even for point patterns where the K-function estimates on neighboring subsamples are not strictly exchangeable....... It also shows improved behavior compared to a test suggested by Diggle et al. (1991, 2000) for the comparison of groups of independently replicated point patterns. In an application to two point patterns from pathology that represent capillary positions in sections of healthy and tumorous tissue, our...

  17. Comparison of aquifer characteristics derived from local and regional aquifer tests.

    Randolph, R.B.; Krause, R.E.; Maslia, M.L.

    1985-01-01

    A comparison of the aquifer parameter values obtained through the analysis of a local and a regional aquifer test involving the same area in southeast Georgia is made in order to evaluate the validity of extrapolating local aquifer-test results for use in large-scale flow simulations. Time-drawdown and time-recovery data were analyzed by using both graphical and least-squares fitting of the data to the Theis curve. Additionally, directional transmissivity, transmissivity tensor, and angle of anisotropy were computed for both tests. -from Authors Georgia drawdown transmissivity regional aquifer tests

  18. Empirical Power Comparison Of Goodness of Fit Tests for Normality In The Presence of Outliers

    Saculinggan, Mayette; Balase, Emily Amor

    2013-01-01

    Most statistical tests such as t-tests, linear regression analysis and Analysis of Variance (ANOVA) require the normality assumptions. When the normality assumption is violated, interpretation and inferences may not be reliable. Therefore it is important to assess such assumption before using any appropriate statistical test. One of the commonly used procedures in determining whether a random sample of size n comes from a normal population are the goodness-of-fit tests for normality. Several studies have already been conducted on the comparison of the different goodness-of-fit(see, for example [2]) but it is generally limited to the sample size or to the number of GOF tests being compared(see, for example [2] [5] [6] [7] [8]). This paper compares the power of six formal tests of normality: Kolmogorov-Smirnov test (see [3]), Anderson-Darling test, Shapiro-Wilk test, Lilliefors test, Chi-Square test (see [1]) and D'Agostino-Pearson test. Small, moderate and large sample sizes and various contamination levels were used to obtain the power of each test via Monte Carlo simulation. Ten thousand samples of each sample size and contamination level at a fixed type I error rate α were generated from the given alternative distribution. The power of each test was then obtained by comparing the normality test statistics with the respective critical values. Results show that the power of all six tests is low for small sample size(see, for example [2]). But for n = 20, the Shapiro-Wilk test and Anderson – Darling test have achieved high power. For n = 60, Shapiro-Wilk test and Liliefors test are most powerful. For large sample size, Shapiro-Wilk test is most powerful (see, for example [5]). However, the test that achieves the highest power under all conditions for large sample size is D'Agostino-Pearson test (see, for example [9]).

  19. False discovery rate control incorporating phylogenetic tree increases detection power in microbiome-wide multiple testing.

    Xiao, Jian; Cao, Hongyuan; Chen, Jun

    2017-09-15

    Next generation sequencing technologies have enabled the study of the human microbiome through direct sequencing of microbial DNA, resulting in an enormous amount of microbiome sequencing data. One unique characteristic of microbiome data is the phylogenetic tree that relates all the bacterial species. Closely related bacterial species have a tendency to exhibit a similar relationship with the environment or disease. Thus, incorporating the phylogenetic tree information can potentially improve the detection power for microbiome-wide association studies, where hundreds or thousands of tests are conducted simultaneously to identify bacterial species associated with a phenotype of interest. Despite much progress in multiple testing procedures such as false discovery rate (FDR) control, methods that take into account the phylogenetic tree are largely limited. We propose a new FDR control procedure that incorporates the prior structure information and apply it to microbiome data. The proposed procedure is based on a hierarchical model, where a structure-based prior distribution is designed to utilize the phylogenetic tree. By borrowing information from neighboring bacterial species, we are able to improve the statistical power of detecting associated bacterial species while controlling the FDR at desired levels. When the phylogenetic tree is mis-specified or non-informative, our procedure achieves a similar power as traditional procedures that do not take into account the tree structure. We demonstrate the performance of our method through extensive simulations and real microbiome datasets. We identified far more alcohol-drinking associated bacterial species than traditional methods. R package StructFDR is available from CRAN. chen.jun2@mayo.edu. Supplementary data are available at Bioinformatics online. © The Author (2017). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  20. Caffeine reversal of ethanol effects on the multiple sleep latency test, memory, and psychomotor performance.

    Drake, Christopher L; Roehrs, Timothy; Turner, Lauren; Scofield, Holly M; Roth, Thomas

    2003-02-01

    Caffeine has been shown to reverse some of the performance-impairing effects of ethanol. However, it is not known whether this antagonistic effect of caffeine is mediated by a reduction in sleepiness. The present study assessed physiological alertness/sleepiness, memory, and psychomotor performance following the administration of placebo, ethanol, and caffeine+ethanol combinations. A total of 13 healthy individuals (21-35 years old) underwent four conditions presented in a Latin Square Design: placebo-placebo, ethanol (0.5 g/kg)-placebo, ethanol (0.5 g/kg)-caffeine 150 mg, and ethanol (0.5 g/kg)-caffeine 300-mg. The Multiple Sleep Latency Test (MSLT), psychomotor performance battery, memory test, and mood/sleepiness questionnaires were administered following each condition. The peak breadth ethanol concentration (BrEC) was 0.043+/-0.0197% and did not differ among the three caffeine treatments. As expected, ethanol reduced mean latency on the MSLT. The lowest caffeine dose reversed this effect and the highest dose increased mean latency (greater alertness) significantly beyond placebo levels. Ethanol also impaired psychomotor performance and memory. The 300-mg caffeine dose restored performance and memory measures to placebo levels. Although visual analog ratings of dizziness were increased by ethanol, they were not diminished by either caffeine dose. In conclusion, Low-dose caffeine prevented the sleepiness and performance impairment associated with a moderate dose of ethanol. Thus, caffeine, similar to other stimulants, can reverse the physiologically sedating effects of ethanol, although other negative effects remain.

  1. Comparison between the Lactation Model and the Test-Day Model ...

    ARC-IRENE

    National Genetic Evaluation, using a Fixed Regression Test-day Model (TDM). This comparison is made for. Ayrshire, Guernsey, Holstein and Jersey cows participating in the South African Dairy Animal Improvement. Scheme. Specific differences between the two models were documented, with differences in statistical.

  2. Preliminary Process Theory does not validate the Comparison Question Test: A comment on Palmatier and Rovner

    Ben-Shakar, G.; Gamer, M.; Iacono, W.; Meijer, E.; Verschuere, B.

    2015-01-01

    Palmatier and Rovner (2015) attempt to establish the construct validity of the Comparison Question Test (CQT) by citing extensive research ranging from modern neuroscience to memory and psychophysiology. In this comment we argue that merely citing studies on the preliminary process theory (PPT) of

  3. A Method for the Comparison of Item Selection Rules in Computerized Adaptive Testing

    Barrada, Juan Ramon; Olea, Julio; Ponsoda, Vicente; Abad, Francisco Jose

    2010-01-01

    In a typical study comparing the relative efficiency of two item selection rules in computerized adaptive testing, the common result is that they simultaneously differ in accuracy and security, making it difficult to reach a conclusion on which is the more appropriate rule. This study proposes a strategy to conduct a global comparison of two or…

  4. Exposure to Community Violence and Sexual Behaviors Among African American Youth: Testing Multiple Pathways.

    Voisin, Dexter R; Hotton, Anna; Neilands, Torsten

    2018-01-01

    African American youth bear a disproportionate burden of sexually transmitted infections. A growing number of studies document that youth exposure to community violence and sexual behaviors are highly correlated. Despite such growing evidence, only a few studies have empirically tested conceptually driven pathways that may account for such relationships. This study seeks to address that gap by exploring multiple pathways linking exposure to community violence and youth sexual behaviors. Using an existing sample of 563 African American youth attending high school, we examined whether possible links between exposure to community violence and sexual activity, sexual risk behaviors were mediated by aggression, low student-teacher connectedness, and negative peer norms. Major findings indicated indirect relationships between exposures to community violence and both sexual activity and risky sex, mediated by aggression and negative peer norms with no significant differences based on gender or socioeconomic status. Overall findings also indicated a significant indirect effect of aggression to risky sex via negative peer norms and from community violence to risky peer norms via aggression. By illuminating ways that community violence, aggression, peer norms, and sexual behaviors are dynamically interrelated, these findings have significant implications for future research and intervention initiatives aimed at addressing the different pathways.

  5. Information processing speed and attention in multiple sclerosis: Reconsidering the Attention Network Test (ANT).

    Roth, Alexandra K; Denney, Douglas R; Lynch, Sharon G

    2015-01-01

    The Attention Network Test (ANT) assesses attention in terms of discrepancies between response times to items that differ in the burden they place on some facet of attention. However, simple arithmetic difference scores commonly used to capture these discrepancies fail to provide adequate control for information processing speed, leading to distorted findings when patient and control groups differ markedly in the speed with which they process and respond to stimulus information. This study examined attention networks in patients with multiple sclerosis (MS) using simple difference scores, proportional scores, and residualized scores that control for processing speed through statistical regression. Patients with relapsing-remitting (N = 20) or secondary progressive (N = 20) MS and healthy controls (N = 40) of similar age, education, and gender completed the ANT. Substantial differences between patients and controls were found on all measures of processing speed. Patients exhibited difficulties in the executive control network, but only when difference scores were considered. When deficits in information processing speed were adequately controlled using proportional or residualized score, deficits in the alerting network emerged. The effect sizes for these deficits were notably smaller than those for overall information processing speed and were also limited to patients with secondary progressive MS. Deficits in processing speed are more prominent in MS than those involving attention, and when the former are properly accounted for, differences in the latter are confined to the alerting network.

  6. Multiplicity distributions of gluon and quark jets and a test of QCD analytic calculations

    Gary, J. William

    1999-01-01

    Gluon jets are identified in e + e - hadronic annihilation events by tagging two quark jets in the same hemisphere of an event. The gluon jet is defined inclusively as all the particles in the opposite hemisphere. Gluon jets defined in this manner have a close correspondence to gluon jets as they are defined for analytic calculations, and are almost independent of a jet finding algorithm. The mean and first few higher moments of the gluon jet charged particle multiplicity distribution are compared to the analogous results found for light quark (uds) jets, also defined inclusively. Large differences are observed between the mean, skew and curtosis values of the gluon and quark jets, but not between their dispersions. The cumulant factorial moments of the distributions are also measured, and are used to test the predictions of QCD analytic calculations. A calculation which includes next-to-next-to-leading order corrections and energy conservation is observed to provide a much improved description of the separated gluon and quark jet cumulant moments compared to a next-to-leading order calculation without energy conservation. There is good quantitative agreement between the data and calculations for the ratios of the cumulant moments between gluon and quark jets. The data sample used is the LEP-1 sample of the OPAL experiment at LEP

  7. Multiplicity distributions of gluon and quark jets and a test of QCD analytic calculations

    Gary, J. William

    1999-03-01

    Gluon jets are identified in e{sup +}e{sup -} hadronic annihilation events by tagging two quark jets in the same hemisphere of an event. The gluon jet is defined inclusively as all the particles in the opposite hemisphere. Gluon jets defined in this manner have a close correspondence to gluon jets as they are defined for analytic calculations, and are almost independent of a jet finding algorithm. The mean and first few higher moments of the gluon jet charged particle multiplicity distribution are compared to the analogous results found for light quark (uds) jets, also defined inclusively. Large differences are observed between the mean, skew and curtosis values of the gluon and quark jets, but not between their dispersions. The cumulant factorial moments of the distributions are also measured, and are used to test the predictions of QCD analytic calculations. A calculation which includes next-to-next-to-leading order corrections and energy conservation is observed to provide a much improved description of the separated gluon and quark jet cumulant moments compared to a next-to-leading order calculation without energy conservation. There is good quantitative agreement between the data and calculations for the ratios of the cumulant moments between gluon and quark jets. The data sample used is the LEP-1 sample of the OPAL experiment at LEP.

  8. Multiplicity distributions of gluon and quark jets and a test of QCD analytic calculations

    Gary, J.W. [California Univ., Riverside, CA (United States). Dept. of Physics

    1999-03-01

    Gluon jets are identified in e{sup +}e{sup -} hadronic annihilation events by tagging two quark jets in the same hemisphere of an event. The gluon jet is defined inclusively as all the particles in the opposite hemisphere. Gluon jets defined in this manner have a close correspondence to gluon jets as they are defined for analytic calculations, and are almost independent of a jet finding algorithm. The mean and first few higher moments of the gluon jet charged particle multiplicity distribution are compared to the analogous results found for light quark (uds) jets, also defined inclusively. Large differences are observed between the mean, skew and curtosis values of the gluon and quark jets, but not between their dispersions. The cumulant factorial moments of the distributions are also measured, and are used to test the predictions of QCD analytic calculations. A calculation which includes next-to-next-to-leading order corrections and energy conservation is observed to provide a much improved description of the separated gluon and quark jet cumulant moments compared to a next-to-leading order calculation without energy conservation. There is good quantitative agreement between the data and calculations for the ratios of the cumulant moments between gluon and quark jets. The data sample used is the LEP-1 sample of the OPAL experiment at LEP. (orig.) 6 refs.

  9. Multiplicity distributions of gluon and quark jets and a test of QCD analytic calculations

    Gary, J.W.

    1999-01-01

    Gluon jets are identified in e + e - hadronic annihilation events by tagging two quark jets in the same hemisphere of an event. The gluon jet is defined inclusively as all the particles in the opposite hemisphere. Gluon jets defined in this manner have a close correspondence to gluon jets as they are defined for analytic calculations, and are almost independent of a jet finding algorithm. The mean and first few higher moments of the gluon jet charged particle multiplicity distribution are compared to the analogous results found for light quark (uds) jets, also defined inclusively. Large differences are observed between the mean, skew and curtosis values of the gluon and quark jets, but not between their dispersions. The cumulant factorial moments of the distributions are also measured, and are used to test the predictions of QCD analytic calculations. A calculation which includes next-to-next-to-leading order corrections and energy conservation is observed to provide a much improved description of the separated gluon and quark jet cumulant moments compared to a next-to-leading order calculation without energy conservation. There is good quantitative agreement between the data and calculations for the ratios of the cumulant moments between gluon and quark jets. The data sample used is the LEP-1 sample of the OPAL experiment at LEP. (orig.)

  10. Multiplicity distributions of gluon and quark jets and a test of QCD analytic calculations

    Gary, J. William

    1999-03-01

    Gluon jets are identified in e +e - hadronic annihilation events by tagging two quark jets in the same hemisphere of an event. The gluon jet is defined inclusively as all the particles in the opposite hemisphere. Gluon hets defined in this manner have a close correspondence to gluon jets as they are defined for analytic calculations, and are almost independent of a jet finding algorithm. The mean and first few higher moments of the gluon jet charged particle multiplicity distribution are compared to the analogous results found for light quark (uds) jets, also defined inclusively. Large differences are observed between the mean, skew and curtosis values of the gluon and quark jets, but not between their dispersions. The cumulant factorial moments of the distributions are also measured, and are used to test the predictions of QCD analytic calculations. A calculation which includes next-to-next-to-leading order corrections and energy conservation is observed to provide a much improved description of the separated gluon and quark jet cumulant moments compared to a next-to-leading order calculation without energy conservation. There is good quantitative agreement between the data and calculations for the ratios of the cumulant moments between gluon and quark jets. The data sample used is the LEP-1 sample of the OPAL experiment at LEP.

  11. Testing a multiple mediator model of the effect of childhood sexual abuse on adolescent sexual victimization.

    Bramsen, Rikke H; Lasgaard, Mathias; Koss, Mary P; Shevlin, Mark; Elklit, Ask; Banner, Jytte

    2013-01-01

    The present study modeled the direct relationship between child sexual abuse (CSA) and adolescent peer-to-peer sexual victimization (APSV) and the mediated effect via variables representing the number of sexual partners, sexual risk behavior, and signaling sexual boundaries. A cross-sectional study on the effect of CSA on APSV was conducted, utilizing a multiple mediator model. Mediated and direct effects in the model were estimated employing Mplus using bootstrapped percentile based confidence intervals to test for significance of mediated effects. The study employed 327 Danish female adolescents with a mean age of 14.9 years (SD = 0.5). The estimates from the mediational model indicated full mediation of the effect of CSA on APSV via number of sexual partners and sexual risk behavior. The current study suggests that the link between CSA and APSV was mediated by sexual behaviors specifically pertaining to situations of social peer interaction, rather than directly on prior experiences of sexual victimization. The present study identifies a modifiable target area for intervention to reduce adolescent sexual revictimization. © 2013 American Orthopsychiatric Association.

  12. MR imaging of multiple fibroadenoma in breast: comparison with color doppler images and histologic findings

    Chung, Soo Young; Yang, Ik; Park, Hai Jung; Lee, Yul; Chung, Bong Wha; Ahn, Hye Kyung [Hallym Univ. College of Medicine, Seoul (Korea, Republic of)

    1997-10-01

    To understand the different signal intensities seen on contrast enhanced magnetic resonance imaging (MRI) in multiple fibroadenoma of the breast, and to compare these with color Doppler ultrasonographic (CDUS) and histologic findings. MRI (1.0 Tesla, TIWI, T2WI, 3D-gradient echo dynamic contrast enhancement study) findings of 24 histologically proven cases of fibroadenoma in five patients were evaluated and compared with the histologic components (myxoid, adenomatous, fibrous). In addition, vascular flow, as seen on CDUS and histologic section, was compared. The observed degree of signal intensity waw classified into three groups, as follows: negative, 8.3%, mild to moderate, 54.2%; marked, 37.5%. On histologic section, the greater the fibrotic component, the higher the intensity of MRI enhancement, the greater the glandular component, and the intensity. CDUS showed vascular flow in only one tumor larger than 3cm in diameter. Vascular patterns of tumors on CDUS were dots in mass and detouring pattern, but in this case and in strongly enhanced cases, tumor vascularity-as seen on histologic section-showed no significant increase. Different signal intensities seen on contrast enhanced MRI in multiple fibroadenoma of the breast may be related more to the amount of glandular and fibrotic component than to increased tumor vascularity.

  13. MR imaging of multiple fibroadenoma in breast: comparison with color doppler images and histologic findings

    Chung, Soo Young; Yang, Ik; Park, Hai Jung; Lee, Yul; Chung, Bong Wha; Ahn, Hye Kyung

    1997-01-01

    To understand the different signal intensities seen on contrast enhanced magnetic resonance imaging (MRI) in multiple fibroadenoma of the breast, and to compare these with color Doppler ultrasonographic (CDUS) and histologic findings. MRI (1.0 Tesla, TIWI, T2WI, 3D-gradient echo dynamic contrast enhancement study) findings of 24 histologically proven cases of fibroadenoma in five patients were evaluated and compared with the histologic components (myxoid, adenomatous, fibrous). In addition, vascular flow, as seen on CDUS and histologic section, was compared. The observed degree of signal intensity waw classified into three groups, as follows: negative, 8.3%, mild to moderate, 54.2%; marked, 37.5%. On histologic section, the greater the fibrotic component, the higher the intensity of MRI enhancement, the greater the glandular component, and the intensity. CDUS showed vascular flow in only one tumor larger than 3cm in diameter. Vascular patterns of tumors on CDUS were dots in mass and detouring pattern, but in this case and in strongly enhanced cases, tumor vascularity-as seen on histologic section-showed no significant increase. Different signal intensities seen on contrast enhanced MRI in multiple fibroadenoma of the breast may be related more to the amount of glandular and fibrotic component than to increased tumor vascularity

  14. Multiple Comparison of Age Groups in Bone Mineral Density under Heteroscedasticity

    Ahmet Sezer

    2015-01-01

    Full Text Available Osteoporosis is a silent disease because individuals may not know that they have osteoporosis until their bones become so fragile. Bone mineral density (BMD test helps to detect osteoporosis and determine the risk fractures. This study covers bone measurement data from total body dual energy X-ray absorptiometry scans for 28,454 persons who participated in the 1996–2006 National Health and Nutrition Examination Survey in USA Dual energy X-ray absorptiometry (DXA method is known as the primary method for detecting osteoporosis because of its high precision and accuracy. Testing the equality of the means of normal populations when the variances are unknown and unequal is a fundamental problem in clinical trials and biomedical research. In this study we compare age groups based upon BMD in case of unequal variance being present among the groups. First we test equality of variances among the age groups by the Hartley test. And then Scott-Smith test is used to test equality of BMD means for the age groups. Finally, Tukey-Cramer confidence intervals are constructed to detect which groups start to differ from the reference group in which BMD reaches the peak level.

  15. Creating a test blueprint for a progress testing program: A paired-comparisons approach.

    von Bergmann, HsingChi; Childs, Ruth A

    2018-03-01

    Creating a new testing program requires the development of a test blueprint that will determine how the items on each test form are distributed across possible content areas and practice domains. To achieve validity, categories of a blueprint are typically based on the judgments of content experts. How experts judgments are elicited and combined is important to the quality of resulting test blueprints. Content experts in dentistry participated in a day-long faculty-wide workshop to discuss, refine, and confirm the categories and their relative weights. After reaching agreement on categories and their definitions, experts judged the relative importance between category pairs, registering their judgments anonymously using iClicker, an audience response system. Judgments were combined in two ways: a simple calculation that could be performed during the workshop and a multidimensional scaling of the judgments performed later. Content experts were able to produce a set of relative weights using this approach. The multidimensional scaling yielded a three-dimensional model with the potential to provide deeper insights into the basis of the experts' judgments. The approach developed and demonstrated in this study can be applied across academic disciplines to elicit and combine content experts judgments for the development of test blueprints.

  16. A critical comparison of respirometric biodegradation tests based on OECD 301 and related test methods.

    Reuschenbach, Peter; Pagga, Udo; Strotmann, Uwe

    2003-04-01

    Biodegradation studies of organic compounds in the aquatic environment gain important information for the final fate of chemicals in the environment. A decisive role play tests for ready biodegradability (OECD 301) and in this context, the respirometric test (OECD 301F). Two different respirometric systems (Oxitop and Sapromat) were compared and in two of ten cases (diethylene glycol and 2-ethylhexylacrylate) differences were observed indicating that the test systems are not always equivalent. For 2-ethylhexylacrylate and cyclohexanone we could not state differences in the extent of biodegradation with a municipal and industrial inoculum whereas for cyclohexanone the degradation rate was faster with a municipal inoculum. Allylthiourea (ATU) proved to be an effective inhibitor of nitrification processes and did not affect the heterotrophic biodegradation activity. Modelling of biodegradation processes could be successfully performed with a first-order and a modified logistic plot. Copyright 2002 Elsevier Science Ltd.

  17. Comparisons of fully automated syphilis tests with conventional VDRL and FTA-ABS tests.

    Choi, Seung Jun; Park, Yongjung; Lee, Eun Young; Kim, Sinyoung; Kim, Hyon-Suk

    2013-06-01

    Serologic tests are widely used for the diagnosis of syphilis. However, conventional methods require well-trained technicians to produce reliable results. We compared automated nontreponemal and treponemal tests with conventional methods. The HiSens Auto Rapid Plasma Reagin (AutoRPR) and Treponema Pallidum particle agglutination (AutoTPPA) tests, which utilize latex turbidimetric immunoassay, were assessed. A total of 504 sera were assayed by AutoRPR, AutoTPPA, conventional VDRL and FTA-ABS. Among them, 250 samples were also tested by conventional TPPA. The concordance rate between the results of VDRL and AutoRPR was 67.5%, and 164 discrepant cases were all VDRL reactive but AutoRPR negative. In the 164 cases, 133 showed FTA-ABS reactivity. Medical records of 106 among the 133 cases were reviewed, and 82 among 106 specimens were found to be collected from patients already treated for syphilis. The concordance rate between the results of AutoTPPA and FTA-ABS was 97.8%. The results of conventional TPPA and AutoTPPA for 250 samples were concordant in 241 cases (96.4%). AutoRPR showed higher specificity than that of VDRL, while VDRL demonstrated higher sensitivity than that of AutoRPR regardless of whether the patients had been already treated for syphilis or not. Both FTA-ABS and AutoTPPA showed high sensitivities and specificities greater than 98.0%. Automated RPR and TPPA tests could be alternatives to conventional syphilis tests, and AutoRPR would be particularly suitable in treatment monitoring, since results by AutoRPR in cases after treatment became negative more rapidly than by VDRL. Copyright © 2013. Published by Elsevier Inc.

  18. Exertional-induced bronchoconstriction: Comparison between cardiopulmonary exercise test and methacholine challenging test

    Mostafa Ghanei

    2015-01-01

    Full Text Available Introduction: Exertional-induced bronchoconstriction is a condition in which the physical activity causes constriction of airways in patients with airway hyper- responsiveness. In this study, we tried to study and evaluate any relationship between the findings of cardiopulmonary exercise testing (CPET and the response to methacholine challenge test (MCT in patients with dyspnea after activity. Materials and Methods: Thirty patients with complaints of dyspnea following activity referred to "Lung Clinic" of Baqiyatallah Hospital but not suffering from asthma were entered into the study. The subjects were excluded from the study if: Suffering from any other pulmonary diseases, smoking more than 1 cigarette a week in the last year, having a history of smoking more than 10 packets of cigarettes/year, having respiratory infection in the past 4 weeks, having abnormal chest X-ray or electrocardiogram, and cannot discontinue the use of medicines interfering with bronchial provocation. Baseline spirometry was performed for all the patients, and the values of forced expiratory volume in 1 second (FEV1, forced vital capacity (FVC, and FEV/FVC were recorded. The MCT and then the CPET were performed on all patients. Results: The mean VO 2 (volume oxygen in patients with positive methacholine test (20.45 mL/kg/min was significantly lower than patients with negative MCT (28.69 mL/kg/min (P = 0.000. Respiratory rates per minute (RR and minute ventilation in the group with positive MCT (38.85 and 1.636 L were significantly lower than the group with negative methacholine test (46.78 and 2.114 L (P < 0.05. Also, the O 2 pulse rate in the group with negative methacholine test (116.27 mL/beat was significantly higher than the group with positive methacholine test (84.26 mL/beat (P < 0.001. Conclusion: Pulmonary response to exercise in patients with positive methacholine test is insufficient. The dead space ventilation in these patients has increased. Also, dynamic

  19. Visual Comparison of Multiple Gene Expression Datasets in a Genomic Context

    Borowski Krzysztof

    2008-06-01

    Full Text Available The need for novel methods of visualizing microarray data is growing. New perspectives are beneficial to finding patterns in expression data. The Bluejay genome browser provides an integrative way of visualizing gene expression datasets in a genomic context. We have now developed the functionality to display multiple microarray datasets simultaneously in Bluejay, in order to provide researchers with a comprehensive view of their datasets linked to a graphical representation of gene function. This will enable biologists to obtain valuable insights on expression patterns, by allowing them to analyze the expression values in relation to the gene locations as well as to compare expression profiles of related genomes or of di erent experiments for the same genome.

  20. Multiple scattering of polarized light: comparison of Maxwell theory and radiative transfer theory.

    Voit, Florian; Hohmann, Ansgar; Schäfer, Jan; Kienle, Alwin

    2012-04-01

    For many research areas in biomedical optics, information about scattering of polarized light in turbid media is of increasing importance. Scattering simulations within this field are mainly performed on the basis of radiative transfer theory. In this study a polarization sensitive Monte Carlo solution of radiative transfer theory is compared to exact Maxwell solutions for all elements of the scattering Müller matrix. Different scatterer volume concentrations are modeled as a multitude of monodisperse nonabsorbing spheres randomly positioned in a cubic simulation volume which is irradiated with monochromatic incident light. For all Müller matrix elements effects due to dependent scattering and multiple scattering are analysed. The results are in overall good agreement between the two methods with deviations related to dependent scattering being prominent for high volume concentrations and high scattering angles.

  1. The Art Gallery Test: A Preliminary Comparison between Traditional Neuropsychological and Ecological VR-Based Tests

    Pedro Gamito

    2017-11-01

    Full Text Available Ecological validity should be the cornerstone of any assessment of cognitive functioning. For this purpose, we have developed a preliminary study to test the Art Gallery Test (AGT as an alternative to traditional neuropsychological testing. The AGT involves three visual search subtests displayed in a virtual reality (VR art gallery, designed to assess visual attention within an ecologically valid setting. To evaluate the relation between AGT and standard neuropsychological assessment scales, data were collected on a normative sample of healthy adults (n = 30. The measures consisted of concurrent paper-and-pencil neuropsychological measures [Montreal Cognitive Assessment (MoCA, Frontal Assessment Battery (FAB, and Color Trails Test (CTT] along with the outcomes from the three subtests of the AGT. The results showed significant correlations between the AGT subtests describing different visual search exercises strategies with global and specific cognitive measures. Comparative visual search was associated with attention and cognitive flexibility (CTT; whereas visual searches involving pictograms correlated with global cognitive function (MoCA.

  2. Comparison of Personal Resources in Patients Who Differently Estimate the Impact of Multiple Sclerosis.

    Wilski, Maciej; Tomczak, Maciej

    2017-04-01

    Discrepancies between physicians' assessment and patients' subjective representations of the disease severity may influence physician-patient communication and management of a chronic illness, such as multiple sclerosis (MS). For these reasons, it is important to recognize factors that distinguish patients who differently estimate the impact of MS. The purpose of this study was to verify if the patients who overestimate or underestimate the impact of MS differ in their perception of personal resources from individuals presenting with a realistic appraisal of their physical condition. A total of 172 women and 92 men diagnosed with MS completed Multiple Sclerosis Impact Scale, University of Washington Self Efficacy Scale, Rosenberg Self-Esteem Scale, Body Esteem Scale, Brief Illness Perception Questionnaire, Treatment Beliefs Scale, Actually Received Support Scale, and Socioeconomic resources scale. Physician's assessment of health status was determined with Expanded Disability Status Scale. Linear regression analysis was conducted to identify the subsets of patients with various patterns of subjective health and Expanded Disability Status Scale (EDSS) scores. Patients overestimating the impact of their disease presented with significantly lower levels of self-esteem, self-efficacy in MS, and body esteem; furthermore, they perceived their condition more threatening than did realists and underestimators. They also assessed anti-MS treatment worse, had less socioeconomic resources, and received less support than underestimators. Additionally, underestimators presented with significantly better perception of their disease, self, and body than did realists. Self-assessment of MS-related symptoms is associated with specific perception of personal resources in coping with the disease. These findings may facilitate communication with patients and point to new directions for future research on adaptation to MS.

  3. Multiple and dependent scattering by densely packed discrete spheres: Comparison of radiative transfer and Maxwell theory

    Ma, L.X.; Tan, J.Y.; Zhao, J.M.; Wang, F.Q.; Wang, C.A.

    2017-01-01

    The radiative transfer equation (RTE) has been widely used to deal with multiple scattering of light by sparsely and randomly distributed discrete particles. However, for densely packed particles, the RTE becomes questionable due to strong dependent scattering effects. This paper examines the accuracy of RTE by comparing with the exact electromagnetic theory. For an imaginary spherical volume filled with randomly distributed, densely packed spheres, the RTE is solved by the Monte Carlo method combined with the Percus–Yevick hard model to consider the dependent scattering effect, while the electromagnetic calculation is based on the multi-sphere superposition T-matrix method. The Mueller matrix elements of the system with different size parameters and volume fractions of spheres are obtained using both methods. The results verify that the RTE fails to deal with the systems with a high-volume fraction due to the dependent scattering effects. Apart from the effects of forward interference scattering and coherent backscattering, the Percus–Yevick hard sphere model shows good accuracy in accounting for the far-field interference effects for medium or smaller size parameters (up to 6.964 in this study). For densely packed discrete spheres with large size parameters (equals 13.928 in this study), the improvement of dependent scattering correction tends to deteriorate. The observations indicate that caution must be taken when using RTE in dealing with the radiative transfer in dense discrete random media even though the dependent scattering correction is applied. - Highlights: • The Muller matrix of randomly distributed, densely packed spheres are investigated. • The effects of multiple scattering and dependent scattering are analyzed. • The accuracy of radiative transfer theory for densely packed spheres is discussed. • Dependent scattering correction takes effect at medium size parameter or smaller. • Performance of dependent scattering correction

  4. Meta-analysis methods for combining multiple expression profiles: comparisons, statistical characterization and an application guideline.

    Chang, Lun-Ching; Lin, Hui-Min; Sibille, Etienne; Tseng, George C

    2013-12-21

    As high-throughput genomic technologies become accurate and affordable, an increasing number of data sets have been accumulated in the public domain and genomic information integration and meta-analysis have become routine in biomedical research. In this paper, we focus on microarray meta-analysis, where multiple microarray studies with relevant biological hypotheses are combined in order to improve candidate marker detection. Many methods have been developed and applied in the literature, but their performance and properties have only been minimally investigated. There is currently no clear conclusion or guideline as to the proper choice of a meta-analysis method given an application; the decision essentially requires both statistical and biological considerations. We performed 12 microarray meta-analysis methods for combining multiple simulated expression profiles, and such methods can be categorized for different hypothesis setting purposes: (1) HS(A): DE genes with non-zero effect sizes in all studies, (2) HS(B): DE genes with non-zero effect sizes in one or more studies and (3) HS(r): DE gene with non-zero effect in "majority" of studies. We then performed a comprehensive comparative analysis through six large-scale real applications using four quantitative statistical evaluation criteria: detection capability, biological association, stability and robustness. We elucidated hypothesis settings behind the methods and further apply multi-dimensional scaling (MDS) and an entropy measure to characterize the meta-analysis methods and data structure, respectively. The aggregated results from the simulation study categorized the 12 methods into three hypothesis settings (HS(A), HS(B), and HS(r)). Evaluation in real data and results from MDS and entropy analyses provided an insightful and practical guideline to the choice of the most suitable method in a given application. All source files for simulation and real data are available on the author's publication website.

  5. Comparison of ring compression testing to three point bend testing for unirradiated ZIRLO cladding

    None, None

    2015-04-01

    Safe shipment and storage of nuclear reactor discharged fuel requires an understanding of how the fuel may perform under the various conditions that can be encountered. One specific focus of concern is performance during a shipment drop accident. Tests at Savannah River National Laboratory (SRNL) are being performed to characterize the properties of fuel clad relative to a mechanical accident condition such as a container drop. Unirradiated ZIRLO tubing samples have been charged with a range of hydride levels to simulate actual fuel rod levels. Samples of the hydrogen charged tubes were exposed to a radial hydride growth treatment (RHGT) consisting of heating to 400°C, applying initial hoop stresses of 90 to 170 MPa with controlled cooling and producing hydride precipitates. Initial samples have been tested using both a) ring compression test (RCT) which is shown to be sensitive to radial hydride and b) three-point bend tests which are less sensitive to radial hydride effects. Hydrides are generated in Zirconium based fuel cladding as a result of coolant (water) oxidation of the clad, hydrogen release, and a portion of the released (nascent) hydrogen absorbed into the clad and eventually exceeding the hydrogen solubility limit. The orientation of the hydrides relative to the subsequent normal and accident strains has a significant impact on the failure susceptability. In this study the impacts of stress, temperature and hydrogen levels are evaluated in reference to the propensity for hydride reorientation from the circumferential to the radial orientation. In addition the effects of radial hydrides on the Quasi Ductile Brittle Transition Temperature (DBTT) were measured. The results suggest that a) the severity of the radial hydride impact is related to the hydrogen level-peak temperature combination (for example at a peak drying temperature of 400°C; 800 PPM hydrogen has less of an impact/ less radial hydride fraction than 200 PPM hydrogen for the same thermal

  6. Comparison between FEM and high heat flux thermal fatigue testing results of ITER divertor plasma facing mock-ups

    Crescenzi, F., E-mail: fabio.crescenzi@enea.it; Roccella, S.; Visca, E.; Moriani, A.

    2014-10-15

    Highlights: • Divertor is an important part of the ITER machine. • Finite element analysis allows designers to explore multiple design options, reducing physical prototypes and optimizing design performance. • The hydraulic thermal-mechanical analysis performed by ANSYS and the test results on small-scale mock-ups manufactured by HRP were compared. • FEA results confirmed many experimental data, then it could be very useful for next design optimization. - Abstract: The divertor is one of the most challenging components of “DEMO” the next step ITER machine, so many tasks regarding modeling and experiments have been made in the past years to assess manufacturing processes, materials and thus the life-time of the components. In this context the finite element analysis (FEA) allows designers to explore multiple design options, to reduce physical prototypes and to optimize design performance. The comparison between the hydraulic thermal-mechanical analysis performed by ANSYS WORKBENCH 14.5 and the test results [1] on small-scale mock-ups manufactured with the Hot Radial Pressing (HRP) [2] technology is presented in this paper. During the thermal fatigue testing in the Efremov TSEFEY facility to assess the heat flux load-carrying capability of the mock-ups, only the surface temperature was measured, so the FEA was important because it allowed to know any other information (temperature inside the materials, local water temperature, local stress, etc.). FEA was performed coupling the thermal-hydraulic analysis, that calculated the temperature distributions on the components and the heat transfer coefficient (HTC) between water and heat sink tube, with the mechanical analysis. The comparison between analysis and testing results was based on the temperature maps of the loaded surface and on number of the cycles supported during the testing and those predicted by the mechanical analysis using the experimental fatigue curves for CuCrZr-IG, that is the structural

  7. Assessment of SPACE code for multiple failure accident: 1% Cold Leg Break LOCA with HPSI failure at ATLAS Test Facility

    Lee, Jong Hyuk; Lee, Seung Wook; Kim, Kyung-Doo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    Design extension conditions (DECs) is a popular key issue after the Fukushima accident. In a viewpoint of the reinforcement of the defense in depth concept, a high-risk multiple failure accident should be reconsidered. The target scenario of ATLAS A5.1 test was LSTF (Large Scale Test Facility) SB-CL-32 test, a 1% SBLOCA with total failure of high pressure safety injection (HPSI) system of emergency core cooling system (ECCS) and secondary side depressurization as the accident management (AM) action, as a counterpart test. As the needs to prepare the DEC accident because of a multiple failure of the present NPPs are emphasized, the capability of SPACE code, just like other system analysis code, is required to expand the DEC area. The objectives of this study is to validate the capability of SPACE code for a DEC scenario, which represents multiple failure accident like as a SBLOCA with HPSI fail. Therefore, the ATLAS A5.1 test scenario was chosen. As the needs to prepare the DEC accident because of a multiple failure of operating NPPs are emphasized, the capability of SPACE code is needed to expand the DEC area. So the capability of SPACE code was validated for one of a DEC scenario. The target scenario was selected as the ATLAS A5.1 test, which is a 1% SBLOCA with total failure of HPSI system of ECCS and secondary side depressurization. Through the sensitivity study on discharge coefficient of break flow, the best fit of integrated mass was found. Using the coefficient, the ATLAS A5.1 test was analyzed using the SPACE code. The major thermal hydraulic parameters such as the system pressure, temperatures were compared with the test and have a good agreement. Through the simulation, it was concluded that the SPACE code can effectively simulate one of multiple failure accidents like as SBLOCA with HPSI failure accident.

  8. Comparison of LOFT zero power physics testing measurement results with predicted values

    Rushton, B.L.; Howe, T.M.

    1978-01-01

    The results of zero power physics testing measurements in LOFT have been evaluated to assess the adequacy of the physics data used in the safety analyses performed for the LOFT FSAR and Technical Specifications. Comparisons of measured data with computed data were made for control rod worths, temperature coefficients, boron worths, and pressure coefficients. Measured boron concentrations at exact critical points were compared with predicted concentrations. Based on these comparisons, the reactivity parameter values used in the LOFT safety analyses were assessed for conservatism

  9. A comparison of likelihood ratio tests and Rao's score test for three separable covariance matrix structures.

    Filipiak, Katarzyna; Klein, Daniel; Roy, Anuradha

    2017-01-01

    The problem of testing the separability of a covariance matrix against an unstructured variance-covariance matrix is studied in the context of multivariate repeated measures data using Rao's score test (RST). The RST statistic is developed with the first component of the separable structure as a first-order autoregressive (AR(1)) correlation matrix or an unstructured (UN) covariance matrix under the assumption of multivariate normality. It is shown that the distribution of the RST statistic under the null hypothesis of any separability does not depend on the true values of the mean or the unstructured components of the separable structure. A significant advantage of the RST is that it can be performed for small samples, even smaller than the dimension of the data, where the likelihood ratio test (LRT) cannot be used, and it outperforms the standard LRT in a number of contexts. Monte Carlo simulations are then used to study the comparative behavior of the null distribution of the RST statistic, as well as that of the LRT statistic, in terms of sample size considerations, and for the estimation of the empirical percentiles. Our findings are compared with existing results where the first component of the separable structure is a compound symmetry (CS) correlation matrix. It is also shown by simulations that the empirical null distribution of the RST statistic converges faster than the empirical null distribution of the LRT statistic to the limiting χ 2 distribution. The tests are implemented on a real dataset from medical studies. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Flow cytometry susceptibility testing for conventional antifungal drugs and Comparison with the NCCLS Broth Macrodilution Test

    M.J. Najafzadeh

    2009-08-01

    Full Text Available Introduction: During the last decade, the incidence of fungal infection has been increased in many countries. Because of the advent of resistant to antifungal agents, determination of an efficient strategic plan for treatment of fungal disease is an important issue in clinical mycology. Many methods have been introduced and developed for determination of invitro susceptibility tests. During the recent years, flow cytometry has developed to solving the problem and many papers have documented the usefulness of this technique. Materials and methods: As the first step, the invitro susceptibility of standard PTCC (Persian Type of Culture Collection strain and some clinical isolates of Candida consisting of Candida albicans, C. dubliniensis, C. glabrata, C. kefyer and C. parapsilosis were evaluated by macrodilution broth method according to NCCLS (National Committee for Clinical Laboratory Standards guidelines and flow cytometry susceptibility test. Results:  The data indicated that macro dilution broth methods and flow cytometry have the same results in determination of MIC (Minimum Inhibitory Concentration for amphotericin B, clotrimazole, fluconazole, ketoconazole and miconazole in C. albicans PTCC 5027 as well as clinical Candida isolates, such as C.albicans, C.dubliniensis, C.glabrata C.kefyr, and C.parapsilosis. Discussion: Comparing the results obtained by macrodilution broth and flow cytometry methods revealed that flow cytometry was faster. It is suggested that flow cytometry susceptibility test can be used as a powerful tool for determination of MIC and administration of the best antifungal drug in treatment of patients with Candida infections.

  11. Final comparison report on ISP-35: Nupec hydrogen mixing and distribution test (Test M-7-1)

    1994-12-01

    This final comparison report summarizes the results of the OECD/CSNI sponsored ISP-35 exercise which was based on NUPEC's Hydrogen Mixing and Distribution Test M-7-1. 12 organizations from 10 different countries took part in the exercise. For the ISP-35 test, a steam/light gas (helium) mixture was released into the lower region of a simplified model of a PWR containment. At the same time, the dome cooling spray was also activated. the transient time histories for gas temperature and concentrations were recorded for each of the 25 compartments of the model containment. The wall temperatures as well as the dome pressure were also recorded. The ISP-35 participants simulated the test conditions and attempted to predict the time histories using their accident analysis codes. Results of these analyses are presented, and comparisons are made between the experimental data and the calculated data. In general, predictions for pressure, helium concentration and gas distribution patterns were achieved with acceptable accuracy

  12. A comparison of single and multiple aliquot TT-OSL data sets for sand-sized quartz from the Arabian Peninsula

    Rosenberg, T.M.; Preusser, F.; Wintle, A.G.

    2011-01-01

    The quartz OSL signal from dune sands from Saudi Arabia and Oman start to saturate at doses of about 100 Gy. In order to try to date dune sands with greater expected doses, a previously published, single-aliquot, regenerative-dose protocol (SAR) for thermally-transferred optically stimulated luminescence (TT-OSL) was tested. Dose recovery tests, recycling and recuperation ratios showed robust functioning and dose response curves demonstrated the potential to extend the dose range to beyond 600 Gy. Multiple aliquot additive dose (MAAD) TT-OSL protocols were used to test for sensitivity changes in the SAR TT-OSL protocol up to doses of 1200 Gy. A strong dose dependent deviation of the SAR TT-OSL relative to the MAAD TT-OSL dose response is observed. Comparison of the TT-OSL and OSL sensitivity data obtained from the MAAD and SAR data sets shows a lack of proportionality between TT-OSL and OSL for the SAR data which will result in a problem when SAR dose response curves are constructed using many regeneration points with doses above 300 Gy.

  13. Ozone flux of an urban orange grove: multiple scaled measurements and model comparisons

    Alstad, K. P.; Grulke, N. E.; Jenerette, D. G.; Schilling, S.; Marrett, K.

    2009-12-01

    There is significant uncertainty about the ozone sink properties of the phytosphere due to a complexity of interactions and feedbacks with biotic and abiotic factors. Improved understanding of the controls on ozone fluxes is critical to estimating and regulating the total ozone budget. Ozone exchanges of an orange orchard within the city of Riverside, CA were examined using a multiple-scaled approach. We access the carbon, water, and energy budgets at the stand- to leaf- level to elucidate the mechanisms controlling the variability in ozone fluxes of this agro-ecosystem. The two initial goals of the study were 1. To consider variations and controls on the ozone fluxes within the canopy; and, 2. To examine different modeling and scaling approaches for totaling the ozone fluxes of this orchard. Current understanding of the total ozone flux between the atmosphere near ground and the phytosphere (F-total) include consideration of a fraction which is absorbed by vegetation through stomatal uptake (F-absorb), and fractional components of deposition on external, non-stomatal, surfaces of the vegetation (F-external) and soil (F-soil). Multiplicative stomatal-conductance models have been commonly used to estimate F-absorb, since this flux cannot be measured directly. We approach F-absorb estimates for this orange orchard using chamber measurement of leaf stomatal-conductance, as well as non-chamber sap-conductance collected on branches of varied aspect and sun/shade conditions within the canopy. We use two approaches to measure the F-total of this stand. Gradient flux profiles were measured using slow-response ozone sensors collecting within and above the canopy (4.6 m), and at the top of the tower (8.5 m). In addition, an eddy-covariance system fitted with a high-frequency chemiluminescence ozone system will be deployed (8.5 m). Preliminary ozone gradient flux profiles demonstrate a substantial ozone sink strength of this orchard, with diurnal concentration differentials

  14. Effectiveness comparison of partially executed t-way test suite based generated by existing strategies

    Othman, Rozmie R.; Ahmad, Mohd Zamri Zahir; Ali, Mohd Shaiful Aziz Rashid; Zakaria, Hasneeza Liza; Rahman, Md. Mostafijur

    2015-05-01

    Consuming 40 to 50 percent of software development cost, software testing is one of the most resource consuming activities in software development lifecycle. To ensure an acceptable level of quality and reliability of a typical software product, it is desirable to test every possible combination of input data under various configurations. Due to combinatorial explosion problem, considering all exhaustive testing is practically impossible. Resource constraints, costing factors as well as strict time-to-market deadlines are amongst the main factors that inhibit such consideration. Earlier work suggests that sampling strategy (i.e. based on t-way parameter interaction or called as t-way testing) can be effective to reduce number of test cases without effecting the fault detection capability. However, for a very large system, even t-way strategy will produce a large test suite that need to be executed. In the end, only part of the planned test suite can be executed in order to meet the aforementioned constraints. Here, there is a need for test engineers to measure the effectiveness of partially executed test suite in order for them to assess the risk they have to take. Motivated by the abovementioned problem, this paper presents the effectiveness comparison of partially executed t-way test suite generated by existing strategies using tuples coverage method. Here, test engineers can predict the effectiveness of the testing process if only part of the original test cases is executed.

  15. Factors influencing behavioral intention to undergo Papanicolaou testing in early adulthood: Comparison of Japanese and Korean women.

    Kang, Kyung-Ah; Kim, Shin-Jeong; Kaneko, Noriyo

    2017-12-01

    In this study, we identified the factors influencing behavioral intention to undergo Papanicolaou testing among Japanese and Korean women in early adulthood. Their behavioral intentions were compared in this cross-sectional descriptive study. In total, 887 women (Japanese = 498, Korean = 389) aged 20-39 years participated in this study. Using a self-report questionnaire, knowledge, attitudes, subjective norm, perceived behavioral control, and behavioral intention were surveyed. There were significant differences between Japanese and Korean women's scores on all main variables. For Japanese women, all the variables moderately correlated with behavioral intention. In comparison, for Korean women, all independent variables, except for knowledge, moderately correlated with behavioral intention. Through a multiple regression analysis, age, undergoing Papanicolaou testing, attitudes, subjective norm, and perceived behavioral control were identified as significant predictors of behavioral intention among Japanese women. Among Korean women, job status, undergoing a Papanicolaou test, attitudes, subjective norm, and perceived behavioral control were demonstrated as significant predictors of behavioral intention. Health professionals should consider these factors to encourage Papanicolaou testing in women in early adulthood. © 2017 John Wiley & Sons Australia, Ltd.

  16. Science Library of Test Items. Volume Twenty-Two. A Collection of Multiple Choice Test Items Relating Mainly to Skills.

    New South Wales Dept. of Education, Sydney (Australia).

    As one in a series of test item collections developed by the Assessment and Evaluation Unit of the Directorate of Studies, items are made available to teachers for the construction of unit tests or term examinations or as a basis for class discussion. Each collection was reviewed for content validity and reliability. The test items meet syllabus…

  17. Science Library of Test Items. Volume Eighteen. A Collection of Multiple Choice Test Items Relating Mainly to Chemistry.

    New South Wales Dept. of Education, Sydney (Australia).

    As one in a series of test item collections developed by the Assessment and Evaluation Unit of the Directorate of Studies, items are made available to teachers for the construction of unit tests or term examinations or as a basis for class discussion. Each collection was reviewed for content validity and reliability. The test items meet syllabus…

  18. Science Library of Test Items. Volume Twenty. A Collection of Multiple Choice Test Items Relating Mainly to Physics, 1.

    New South Wales Dept. of Education, Sydney (Australia).

    As one in a series of test item collections developed by the Assessment and Evaluation Unit of the Directorate of Studies, items are made available to teachers for the construction of unit tests or term examinations or as a basis for class discussion. Each collection was reviewed for content validity and reliability. The test items meet syllabus…

  19. Science Library of Test Items. Volume Seventeen. A Collection of Multiple Choice Test Items Relating Mainly to Biology.

    New South Wales Dept. of Education, Sydney (Australia).

    As one in a series of test item collections developed by the Assessment and Evaluation Unit of the Directorate of Studies, items are made available to teachers for the construction of unit tests or term examinations or as a basis for class discussion. Each collection was reviewed for content validity and reliability. The test items meet syllabus…

  20. Science Library of Test Items. Volume Nineteen. A Collection of Multiple Choice Test Items Relating Mainly to Geology.

    New South Wales Dept. of Education, Sydney (Australia).

    As one in a series of test item collections developed by the Assessment and Evaluation Unit of the Directorate of Studies, items are made available to teachers for the construction of unit tests or term examinations or as a basis for class discussion. Each collection was reviewed for content validity and reliability. The test items meet syllabus…

  1. A semi-field approach to testing effects of fresh pesticide residues on bees in multiple-rate test

    Bakker, F.; Calis, J.N.M.

    2003-01-01

    We describe a semi-field cage test specifically designed to test effects of delayed exposure to plant protection products. The trial involved the use of standardised mini-beehives. The principle of the trial was to prepare two groups of potted test plants per treatment. The first group of plants

  2. Comparing Effects of Biologic Agents in Treating Patients with Rheumatoid Arthritis: A Multiple Treatment Comparison Regression Analysis.

    Ingunn Fride Tvete

    Full Text Available Rheumatoid arthritis patients have been treated with disease modifying anti-rheumatic drugs (DMARDs and the newer biologic drugs. We sought to compare and rank the biologics with respect to efficacy. We performed a literature search identifying 54 publications encompassing 9 biologics. We conducted a multiple treatment comparison regression analysis letting the number experiencing a 50% improvement on the ACR score be dependent upon dose level and disease duration for assessing the comparable relative effect between biologics and placebo or DMARD. The analysis embraced all treatment and comparator arms over all publications. Hence, all measured effects of any biologic agent contributed to the comparison of all biologic agents relative to each other either given alone or combined with DMARD. We found the drug effect to be dependent on dose level, but not on disease duration, and the impact of a high versus low dose level was the same for all drugs (higher doses indicated a higher frequency of ACR50 scores. The ranking of the drugs when given without DMARD was certolizumab (ranked highest, etanercept, tocilizumab/ abatacept and adalimumab. The ranking of the drugs when given with DMARD was certolizumab (ranked highest, tocilizumab, anakinra/rituximab, golimumab/ infliximab/ abatacept, adalimumab/ etanercept [corrected]. Still, all drugs were effective. All biologic agents were effective compared to placebo, with certolizumab the most effective and adalimumab (without DMARD treatment and adalimumab/ etanercept (combined with DMARD treatment the least effective. The drugs were in general more effective, except for etanercept, when given together with DMARDs.

  3. A comparison between fast and conventional spin-echo in the detection of multiple sclerosis lesions

    Thorpe, J.W.; Halpin, S.F.; MacManus, D.G.; Barker, G.J.; Kendall, B.E.; Miller, D.H.

    1994-01-01

    Long repetition time (TR) spin-echo (SE) with T 2 - or proton density weighting is the sequence of choice to detect the brain lesions of multiple sclerosis (MS). Fast spin-echo (FSE) permits the generation of T 2 -weighted images with similar contrast to SE but in a fraction of the time. We compared the sensitivity of FSE and SE in the detection of the brain lesions of MS. Six patients with clinically definite MS underwent brain imaging with both dual echo (long TR, long and short echo time (TE) SE and dual echo FSE. The SE and FSE images were first reviewed independently and then compared. A total of 404 lesions was detected on SE and 398 on FSE. Slightly more periventricular lesions were detected using SE than FSE (145 vs 127), whereas more posterior cranial fossa lesions were detected by FSE (77 vs 57). With both SE and FSE the short TE images revealed more lesions than the long echo. These results suggest that FSE could replace SE as the long TR sequence of choice in the investigation of MS. (orig.)

  4. Multiple scattering of low energy rare gas ions: a comparison of experiment and computer simulation

    Heiland, W.; Taglauer, E.; Robinson, M.T.

    1976-01-01

    Some aspects of ion scattering below a few keV have been interpreted by multiple scattering. This can partly be simulated by chain or string models, where the single crystal surface is replaced by a chain of atoms. The computer program MARLOWE allows a simulation of solid-ion interaction, which is much closer to reality, e.g. the crystal is three-dimensional, includes lattice vibrations, electronic stopping power, different scattering potentials, etc. It is shown that the energy of the reflected ions as a function of the primary energy, lattice constant, impact angle and scattering angle can be understood within the string model. These results of the string model are confirmed by the MARLOWE calculations. For an interpretation of the measured intensities the simple string model is insufficient, whereas with MARLOWE reasonable agreement with experimental data may be achieved, if the thermal vibrations of the lattice atoms are taken into account. The experimental data include Ne + →Ni, Ne + →Ag and preliminary data on Ne + →W. The screening parameters of the scattering potentials are estimated for these ion-atom combinations. The results allow some conclusions about surface Debye temperatures. (Auth.)

  5. Characteristic MRI findings in multiple system atrophy: comparison of the three subtypes

    Naka, H.; Ohshita, T.; Murata, Y.; Imon, Y.; Mimori, Y.; Nakamura, S. [Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima (Japan)

    2002-03-01

    We reviewed MRI findings in 29 patients with probable multiple system atrophy (MSA) to see whether there were common and or less common neuroradiological findings in the various clinical subtypes. We divided the patients into three clinical subtypes according to initial and predominant symptoms: 14 with olivopontocerebellar atrophy (OPCA), eight with the Shy-Drager syndrome (SDS) and seven with striatonigral degeneration (SND). The patients showed atrophy of the brain stem and cerebellum, high signal on T2-weighted images of the base of the pons and middle cerebellar peduncles, high and low signal on T2-weighted images of the putamen and atrophy of frontal and parietal lobes. The degree of atrophy of the middle cerebellar peduncle and cerebellum was greater in OPCA patients and a high-signal lateral rim to the putamen more frequent in SND. However, all findings were observed in all subtypes, and the degrees of atrophy of the putamen and pons and the frequency of high signal in the base of the pons were similar in the subtypes. We also found atrophy of the cerebral hemispheres, especially the frontal and parietal lobes, but its degree was not significantly different in the various subtypes. Our findings suggest that, although MSA can be divided clinically into three subtypes, most of the features on MRI are common and overlap in the subtypes, independently of the clinical presentation. (orig.)

  6. Comparison of Personality Characteristics and Coping Strategies in Patients With Multiple Sclerosis and Control Group

    Mohammadi

    2015-09-01

    Full Text Available Background The present study aimed to investigate personality traits and coping strategies in patients with multiple sclerosis (MS who were admitted to Sina hospital compared with healthy individuals. Objectives The aim of the present study was to compare personality characteristics and coping strategies between patients with MS and healthy controls. Materials and Methods The study sample included 55 patients with MS and 57 matched healthy control individuals. The data were gathered via a demographic form, the ways of coping questionnaire, and the NEO five-factor inventory. The data were analyzed by multivariate analysis of variance (MANOVA, Pearson’s correlation coefficient, and logistic regression. Results No significant differences in personality characteristics were observed between patients and healthy controls (all P > 0.05. Only the coping strategy subscale of Distancing was significant between patients and healthy controls (P 0.05. Only the Neuroticism personality trait and the Distancing coping strategy were predictive of group membership (i.e., healthy or patient. Conclusions Our study suggests that the personality traits of patients with MS and healthy individuals are not significantly different. Patients with MS are likely to use the same coping strategies as healthy individuals, except in the subscale of Distancing.

  7. Ventricular enlargement in multiple sclerosis: a comparison of three-dimensional and linear MRI estimates

    Turner, B.; Blumhardt, L.D.; Ramli, N.; Jaspan, T.

    2001-01-01

    Atrophy of central white matter is related to irreversible clinical disability in multiple sclerosis (MS) and ventricular enlargement may be a sensitive marker of this tissue loss. Therapeutic trials in MS have provided MRI data for investigation of cerebral atrophy in MS. These studies use almost exclusively two-dimensional (2-D) images, which may be limited in the assessment of three-dimensional (3-D) structures. We used 3-D MRI data to estimate ventricular volumes in 40 patients with MS and 10 healthy controls, to look at associations with clinical disability and the stage of the disease. We then compared simple linear measures of ventricular size from conventional 2-D images, with 3-D volume estimates to establish the best available linear indices of ventricular volume. Mean ventricular volumes were increased in the patients and significantly larger in the more disabled patients. The estimated volume of the third ventricle obtained from 3-D MRI showed the strongest association with the clinical stage of the disease, duration of symptoms and levels of disability. Finally, we confirmed that in patients with MS accurate data on ventricular size can be obtained from 2-D images by two simple and convenient linear measures, the width of the third ventricle and of the anterior horn of the lateral ventricle. (orig.)

  8. Multiple species comparison of cardiac troponin T and dystrophin: unravelling the DNA behind dilated cardiomyopathy

    England, Jennifer; Loughna, Siobhan; Rutland, Catrin S.

    2017-01-01

    Animals have frequently been used as models for human disorders and mutations. Following advances in genetic testing and treatment options, and the decreasing cost of these technologies in the clinic, mutations in both companion and commercial animals are now being investigated. A recent review highlighted the genes associated with both human and non-human dilated cardiomyopathy. Cardiac troponin T and dystrophin were observed to be associated with both human and turkey (troponin T) and canin...

  9. Comparison of the sensitivity of typhi dot test with blood culture in typhoid

    Rizvi, Q [Hamdard College of Medicine, Karachi (Pakistan). Dept. of Pharmacology

    2006-10-15

    To evaluate the sensitivity of Typhi Dot test in comparison to Blood Culture for the diagnosis of Typhoid Fever in our setup. Fifty patients who fulfilled the clinical criteria of having Typhoid Fever. The data of all the patients was documented, and they were submitted to the Typhi Dot and Blood Culture tests, apart from other routine investigations. Out of the total 50 patients, 47(94%) had their Blood Culture positive for Typhoid bacillus, while in 49 (98%) the Typhi Dot test was positive. Two patients which were found positive on Typhi dot test, gave negative results on Blood Culture. One patient with the signs and symptoms of Typhoid Fever was found neither positive on Typhi Dot test nor upon Blood Culture. There was no significant difference between the results of Blood Culture and Typhi Dot test in the diagnosis of Typhoid Fever. However, Typhi Dot has the advantages of being less expensive and quicker in giving results with excellent sensitivity. (author)

  10. Comparison of the sensitivity of typhi dot test with blood culture in typhoid

    Rizvi, Q.

    2006-01-01

    To evaluate the sensitivity of Typhi Dot test in comparison to Blood Culture for the diagnosis of Typhoid Fever in our setup. Fifty patients who fulfilled the clinical criteria of having Typhoid Fever. The data of all the patients was documented, and they were submitted to the Typhi Dot and Blood Culture tests, apart from other routine investigations. Out of the total 50 patients, 47(94%) had their Blood Culture positive for Typhoid bacillus, while in 49 (98%) the Typhi Dot test was positive. Two patients which were found positive on Typhi dot test, gave negative results on Blood Culture. One patient with the signs and symptoms of Typhoid Fever was found neither positive on Typhi Dot test nor upon Blood Culture. There was no significant difference between the results of Blood Culture and Typhi Dot test in the diagnosis of Typhoid Fever. However, Typhi Dot has the advantages of being less expensive and quicker in giving results with excellent sensitivity. (author)

  11. Comparison of a Ring On-Chip Network and a Code-Division Multiple-Access On-Chip Network

    Xin Wang

    2007-01-01

    Full Text Available Two network-on-chip (NoC designs are examined and compared in this paper. One design applies a bidirectional ring connection scheme, while the other design applies a code-division multiple-access (CDMA connection scheme. Both of the designs apply globally asynchronous locally synchronous (GALS scheme in order to deal with the issue of transferring data in a multiple-clock-domain environment of an on-chip system. The two NoC designs are compared with each other by their network structures, data transfer principles, network node structures, and their asynchronous designs. Both the synchronous and the asynchronous designs of the two on-chip networks are realized using a hardware-description language (HDL in order to make the entire designs suit the commonly used synchronous design tools and flow. The performance estimation and comparison of the two NoC designs which are based on the HDL realizations are addressed. By comparing the two NoC designs, the advantages and disadvantages of applying direct connection and CDMA connection schemes in an on-chip communication network are discussed.

  12. Comparison of Optical Coherence Tomography and Scanning Laser Polarimetry Measurements in Patients with Multiple Sclerosis

    Quelly, Amanda; Cheng, Han; Laron, Michal; Schiffman, Jade S.; Tang, Rosa A.

    2010-01-01

    Purpose To compare optical coherence tomography (OCT) and scanning laser polarimetry (GDx) measurements of the retinal nerve fiber layer (RNFL) in multiple sclerosis (MS) patients with and without optic neuritis (ON). Methods OCT and GDx were performed on 68 MS patients. Qualifying eyes were divided into two groups: 51 eyes with an ON history ≥ 6 months prior (ON eyes), and 65 eyes with no history of ON (non-ON eyes). Several GDx and OCT parameters and criteria were used to define an eye as abnormal, for example, GDx nerve fiber indicator (NFI) above 20 or 30, OCT average RNFL thickness and GDx temporal-superior-nasal-inferior-temporal average (TSNIT) below 5% or 1% of the instruments’ normative database. Agreement between OCT and GDx parameters was reported as percent of observed agreement, along with the AC1 statistic. Linear regression analyses were used to examine the relationship between OCT average RNFL thickness and GDx NFI and TSNIT. Results All OCT and GDx measurements showed significantly more RNFL damage in ON than in non-ON eyes. Agreement between OCT and GDx parameters ranged from 69–90% (AC1 0.37–0.81) in ON eyes, and 52–91% (AC1 = 0.21–0.90) in non-ON eyes. Best agreement was observed between OCT average RNFL thickness (P 30) in ON eyes (90%, AC1 = 0.81), and between OCT average RNFL thickness (P < 0.01) and GDx TSNIT average (P < 0.01) in non-ON eyes (91%, AC1 = 0.90). In ON eyes, the OCT average RNFL thickness showed good linear correlation with NFI (R2 = 0.69, P < 0.0001) and TSNIT (R2 = 0.55, P < 0.0001). Conclusions OCT and GDx show good agreement and can be useful in detecting RNFL loss in MS/ON eyes. PMID:20495500

  13. Identification of alternative splice variants in Aspergillus flavus through comparison of multiple tandem MS search algorithms

    Chang Kung-Yen

    2011-07-01

    Full Text Available Abstract Background Database searching is the most frequently used approach for automated peptide assignment and protein inference of tandem mass spectra. The results, however, depend on the sequences in target databases and on search algorithms. Recently by using an alternative splicing database, we identified more proteins than with the annotated proteins in Aspergillus flavus. In this study, we aimed at finding a greater number of eligible splice variants based on newly available transcript sequences and the latest genome annotation. The improved database was then used to compare four search algorithms: Mascot, OMSSA, X! Tandem, and InsPecT. Results The updated alternative splicing database predicted 15833 putative protein variants, 61% more than the previous results. There was transcript evidence for 50% of the updated genes compared to the previous 35% coverage. Database searches were conducted using the same set of spectral data, search parameters, and protein database but with different algorithms. The false discovery rates of the peptide-spectrum matches were estimated Conclusions We were able to detect dozens of new peptides using the improved alternative splicing database with the recently updated annotation of the A. flavus genome. Unlike the identifications of the peptides and the RefSeq proteins, large variations existed between the putative splice variants identified by different algorithms. 12 candidates of putative isoforms were reported based on the consensus peptide-spectrum matches. This suggests that applications of multiple search engines effectively reduced the possible false positive results and validated the protein identifications from tandem mass spectra using an alternative splicing database.

  14. A comparison of random forest regression and multiple linear regression for prediction in neuroscience.

    Smith, Paul F; Ganesh, Siva; Liu, Ping

    2013-10-30

    Regression is a common statistical tool for prediction in neuroscience. However, linear regression is by far the most common form of regression used, with regression trees receiving comparatively little attention. In this study, the results of conventional multiple linear regression (MLR) were compared with those of random forest regression (RFR), in the prediction of the concentrations of 9 neurochemicals in the vestibular nucleus complex and cerebellum that are part of the l-arginine biochemical pathway (agmatine, putrescine, spermidine, spermine, l-arginine, l-ornithine, l-citrulline, glutamate and γ-aminobutyric acid (GABA)). The R(2) values for the MLRs were higher than the proportion of variance explained values for the RFRs: 6/9 of them were ≥ 0.70 compared to 4/9 for RFRs. Even the variables that had the lowest R(2) values for the MLRs, e.g. ornithine (0.50) and glutamate (0.61), had much lower proportion of variance explained values for the RFRs (0.27 and 0.49, respectively). The RSE values for the MLRs were lower than those for the RFRs in all but two cases. In general, MLRs seemed to be superior to the RFRs in terms of predictive value and error. In the case of this data set, MLR appeared to be superior to RFR in terms of its explanatory value and error. This result suggests that MLR may have advantages over RFR for prediction in neuroscience with this kind of data set, but that RFR can still have good predictive value in some cases. Copyright © 2013 Elsevier B.V. All rights reserved.

  15. White matter tract-specific quantitative analysis in multiple sclerosis: Comparison of optic radiation reconstruction techniques.

    Chenyu Wang

    Full Text Available The posterior visual pathway is commonly affected by multiple sclerosis (MS pathology that results in measurable clinical and electrophysiological impairment. Due to its highly structured retinotopic mapping, the visual pathway represents an ideal substrate for investigating patho-mechanisms in MS. Therefore, a reliable and robust imaging segmentation method for in-vivo delineation of the optic radiations (OR is needed. However, diffusion-based tractography approaches, which are typically used for OR segmentation are confounded by the presence of focal white matter lesions. Current solutions require complex acquisition paradigms and demand expert image analysis, limiting application in both clinical trials and clinical practice. In the current study, using data acquired in a clinical setting on a 3T scanner, we optimised and compared two approaches for optic radiation (OR reconstruction: individual probabilistic tractography-based and template-based methods. OR segmentation results were applied to subjects with MS and volumetric and diffusivity parameters were compared between OR segmentation techniques. Despite differences in reconstructed OR volumes, both OR lesion volume and OR diffusivity measurements in MS subjects were highly comparable using optimised probabilistic tractography-based, and template-based, methods. The choice of OR reconstruction technique should be determined primarily by the research question and the nature of the available dataset. Template-based approaches are particularly suited to the semi-automated analysis of large image datasets and have utility even in the absence of dMRI acquisitions. Individual tractography methods, while more complex than template based OR reconstruction, permit measurement of diffusivity changes along fibre bundles that are affected by specific MS lesions or other focal pathologies.

  16. Evaluation of an ex vivo murine local lymph node assay: multiple endpoint comparison.

    Piccotti, Joseph R; Knight, Stephanie A; Gillhouse, Kimberly; Lagattuta, Mark S; Bleavins, Michael R

    2006-01-01

    The local lymph node assay (LLNA) is used to assess the skin sensitization potential of chemicals. In the standard assay, mice are treated topically on the dorsum of both ears with test substance for 3 days. Following 2 days of rest, the initiation of the hypersensitivity response is evaluated by injecting (3)H-thymidine into a tail vein, and then measuring the levels of radioisotope incorporated into the DNA of lymph node cells draining the ears. In the current study, BALB/c mice were treated with the contact sensitizers hexylcinnamic aldehyde (HCA) and oxazolone, and the nonsensitizer methyl salicylate. The proliferative response of lymph node cells was evaluated in an ex vivo assay, in which isolated cells were cultured in vitro with (3)H-thymidine. Treatment of mice with HCA at 5-50% resulted in concentration-related increases in (3)H-thymidine incorporation, with stimulation indices ranging from 3 to 14. Low animal-to-animal variability was seen in three replicate assays testing HCA at 25%. As anticipated, the proliferative response induced by the potent sensitizer oxazolone at 0.25% was greater than HCA at all concentrations tested. Stimulation indices of 1.5 and 3 were seen in two independent experiments with methyl salicylate. These equivocal findings were likely due to the irritancy properties of the compound. Importantly, measuring ex vivo (3)H-thymidine incorporation was more sensitive than evaluating lymph node weight and cellularity, and in vitro bromodeoxyuridine incorporation. Furthermore, the results of the ex vivo LLNA were comparable to the standard assay. This study provided evidence that supports the use of an ex vivo LLNA for hazard assessment of contact hypersensitivity. Copyright 2006 John Wiley & Sons, Ltd.

  17. Multiple Species Comparison of Cardiac Troponin T and Dystrophin: Unravelling the DNA behind Dilated Cardiomyopathy

    Jennifer England

    2017-07-01

    Full Text Available Animals have frequently been used as models for human disorders and mutations. Following advances in genetic testing and treatment options, and the decreasing cost of these technologies in the clinic, mutations in both companion and commercial animals are now being investigated. A recent review highlighted the genes associated with both human and non-human dilated cardiomyopathy. Cardiac troponin T and dystrophin were observed to be associated with both human and turkey (troponin T and canine (dystrophin dilated cardiomyopathies. This review gives an overview of the work carried out in cardiac troponin T and dystrophin to date in both human and animal dilated cardiomyopathy.

  18. Multiple Species Comparison of Cardiac Troponin T and Dystrophin: Unravelling the DNA behind Dilated Cardiomyopathy.

    England, Jennifer; Loughna, Siobhan; Rutland, Catrin Sian

    2017-07-07

    Animals have frequently been used as models for human disorders and mutations. Following advances in genetic testing and treatment options, and the decreasing cost of these technologies in the clinic, mutations in both companion and commercial animals are now being investigated. A recent review highlighted the genes associated with both human and non-human dilated cardiomyopathy. Cardiac troponin T and dystrophin were observed to be associated with both human and turkey (troponin T) and canine (dystrophin) dilated cardiomyopathies. This review gives an overview of the work carried out in cardiac troponin T and dystrophin to date in both human and animal dilated cardiomyopathy.

  19. Making a difference? A comparison between multi-sensory and regular storytelling for persons with profound intellectual and multiple disabilities.

    Ten Brug, A; Van der Putten, A A J; Penne, A; Maes, B; Vlaskamp, C

    2016-11-01

    Multi-sensory storytelling (MSST) was developed to include persons with profound intellectual and multiple disabilities in storytelling culture. In order to increase the listeners' attention, MSST stories are individualised and use multiple sensory stimuli to support the verbal text. In order to determine the value of MSST, this study compared listeners' attention under two conditions: (1) being read MSST books and (2) being read regular stories. A non-randomised control study was executed in which the intervention group read MSST books (n = 45) and a comparison group (n = 31) read regular books. Books were read 10 times during a 5-week period. The 1st, 5th and 10th storytelling sessions were recorded on video in both groups, and the percentage of attention directed to the book and/or stimuli and to the storyteller was scored by a trained and independent rater. Two repeated measure analyses (with the storytelling condition as a between-subject factor and the three measurements as factor) were performed to determine the difference between the groups in terms of attention directed to the book/stimuli (first analysis) and storyteller (second analysis). A further analysis established whether the level of attention changed between the reading sessions and whether there was an interaction effect between the repetition of the book and the storytelling condition. The attention directed to the book and/or the stimuli was significantly higher in the MSST group than in the comparison group. No significant difference between the two groups was found in the attention directed to the storyteller. For MSST stories, most attention was observed during the fifth reading session, while for regular stories, the fifth session gained least attentiveness from the listener. The persons with profound intellectual and multiple disabilities paid more attention to the book and/or stimuli in the MSST condition compared with the regular story telling group. Being more attentive towards

  20. Pharmacotherapies for chronic obstructive pulmonary disease: a multiple treatment comparison meta-analysis

    Ghement I

    2011-03-01

    Full Text Available Edward J Mills1, Eric Druyts1, Isabella Ghement2, Milo A Puhan31Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada; 2Ghement Statistical Consulting Company, Richmond, British Columbia, Canada; 3Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USABackground: Most patients with moderate and severe chronic obstructive pulmonary disease (COPD receive long-acting bronchodilators (LABA for symptom control. It is, however, unclear if and what drug treatments should be added to LABAs to reduce exacerbations, which is an important goal of COPD management. Since current guidelines cannot make strong recommendations yet, our aim was to determine the relative efficacy of existing treatments and combinations to reduce the risk for COPD exacerbations.Methods: We included randomized clinical trials (RCTs evaluating long-acting ß2 agonists (LABA, long-acting muscarinic antagonists (LAMA, inhaled glucocorticosterioids (ICS, and the phosphodiesterase-4 (PDE4 inhibitor roflumilast, and combinations of these interventions in moderate to severe COPD populations. Our primary outcome was the event rate of exacerbations. We conducted a random-effects Bayesian mixed-treatment comparison (MTC and applied several sensitivity analyses. In particular, we confirmed our findings using a binomial MTC analysis examining whether a patient experienced at least one exacerbation event or not during the trial. We also used an additive assumption to calculate the combined effects of treatments that were not included in the systematic review.Results: Twenty-six studies provided data on the total number of exacerbations and/or the mean annual rate of exacerbations among a combined 36,312 patients. There were a total of 10 treatment combinations in the MTC and 15 in the additive analysis. Compared with all other treatments, the combination of roflumilast plus LAMA exhibited the largest treatment

  1. Shared Authentic Leadership in Research Teams: Testing a Multiple Mediation Model

    Günter, Hannes; Gardner, William L.; Davis McCauley, Kelly; Randolph-Seng, Brandon; P. Prahbu, Veena

    2017-01-01

    Research teams face complex leadership and coordination challenges. We propose shared authentic leadership (SAL) as a timely approach to addressing these challenges. Drawing from authentic and functional leadership theories, we posit a multiple mediation model that suggests three mechanisms whereby

  2. Solar test of Dirac's large number hypothesis. [multiplicative creation model for solar evolution

    Chin, C.-W.; Stothers, R.

    1975-01-01

    An investigation is conducted regarding the implications of Dirac's theories (1973, 1974) concerning the creation of new matter. It is found that Dirac's theory of multiplicative creation, but not his theory of additive creation, is not in contradiction with known facts about the sun. According to the theory of additive creation, matter is formed uniformly throughout space. The concept of multiplicative creation implies that existing matter multiplies itself in proportion to the amount of matter already present.

  3. Gender and Ethnicity Differences in Multiple-Choice Testing. Effects of Self-Assessment and Risk-Taking Propensity

    1993-05-01

    correctness of the response provides I some advantages. They are: i 1. Increased reliability of the test; 2. Examinees pay more attention to the multiple...their choice 3 of test date. Each sign up sheet was divided into four cells: Non-Hispanic males and females and Hispanic males and females. 3 I I I...certain prestige and financial rewards; or entering a conservatory of music for advanced training with a well-known pianist . Mr. H realizes that even

  4. The Langer-Improved Wald Test for DIF Testing with Multiple Groups: Evaluation and Comparison to Two-Group IRT

    Woods, Carol M.; Cai, Li; Wang, Mian

    2013-01-01

    Differential item functioning (DIF) occurs when the probability of responding in a particular category to an item differs for members of different groups who are matched on the construct being measured. The identification of DIF is important for valid measurement. This research evaluates an improved version of Lord's chi [superscript 2]…

  5. Effectiveness of Guided Multiple Choice Objective Questions Test on Students' Academic Achievement in Senior School Mathematics by School Location

    Igbojinwaekwu, Patrick Chukwuemeka

    2015-01-01

    This study investigated, using pretest-posttest quasi-experimental research design, the effectiveness of guided multiple choice objective questions test on students' academic achievement in Senior School Mathematics, by school location, in Delta State Capital Territory, Nigeria. The sample comprised 640 Students from four coeducation secondary…

  6. Preliminary report of the comparison of multiple non-destructive assay techniques on LANL Plutonium Facility waste drums

    Bonner, C.; Schanfein, M.; Estep, R.

    1999-01-01

    Prior to disposal, nuclear waste must be accurately characterized to identify and quantify the radioactive content. The DOE Complex faces the daunting task of measuring nuclear material with both a wide range of masses and matrices. Similarly daunting can be the selection of a non-destructive assay (NDA) technique(s) to efficiently perform the quantitative assay over the entire waste population. In fulfilling its role of a DOE Defense Programs nuclear User Facility/Technology Development Center, the Los Alamos National Laboratory Plutonium Facility recently tested three commercially built and owned, mobile nondestructive assay (NDA) systems with special nuclear materials (SNM). Two independent commercial companies financed the testing of their three mobile NDA systems at the site. Contained within a single trailer is Canberra Industries segmented gamma scanner/waste assay system (SGS/WAS) and neutron waste drum assay system (WDAS). The third system is a BNFL Instruments Inc. (formerly known as Pajarito Scientific Corporation) differential die-away imaging passive/active neutron (IPAN) counter. In an effort to increase the value of this comparison, additional NDA techniques at LANL were also used to measure these same drums. These are comprised of three tomographic gamma scanners (one mobile unit and two stationary) and one developmental differential die-away system. Although not certified standards, the authors hope that such a comparison will provide valuable data for those considering these different NDA techniques to measure their waste as well as the developers of the techniques

  7. International Comparisons of Income Inequality: Tests for Lorenz Dominance across Nine Countries

    Bishop, John; Smith, W. James; Formby, John

    1989-01-01

    This paper examines income inequality across nine countries using the Luxembourg Income Study data set. New statistical tests and comparability of data provide an exceptionally clear picture of relative income inequality. Only 4 comparisons out of a possible 108 cannot be ranked. In most cases, differences in the definition of the recipient unit make little difference in the rankings. Irrespective of recipient units, Sweden, Norway, and Germany come out at the top of the ordinal Lorenz rankin...

  8. Multiple unit root tests under uncertainty over the initial condition : some powerful modifications

    Hanck, C.

    We modify the union-of-rejection unit root test of Harvey et al. "Unit Root Testing in Practice: Dealing with Uncertainty over the Trend and Initial Condition" (Harvey, Econom Theory 25:587-636, 2009). This test rejects if either of two different unit root tests rejects but controls the inherent

  9. Comparison between immediate and delayed imaging after gadolinium chelate injection for detecting enhanced lesions in multiple sclerosis

    Alizadeh, A.; Roudbari, A.; Heidarzadeh, A.; Kouhsari, M.

    2010-01-01

    Magnetic resonance imaging is a noninvasive and valuable method in the diagnosis of Multiple Sclerosis. Compared with other modalities, the sensitivity of Magnetic resonance imaging for detection of the lesion increases using magnetization transfer and delayed imaging. Our aim was to compare the two methods in detecting Multiple Sclerosis lesions. Patients and Methods: In this double-blind clinical trial, twenty-one patients with the definite diagnosis of Multiple Sclerosis referred to Poursina Hospital, Rasht were included. Two radiologists evaluated all the images. First, images without contrast were conducted, then 0.1 mmol/kg contrast material (Dotarem, single dose) was injected and after 30 minutes, T1W and magnetization transfer images were obtained. Seventy-two hours later, T1W images were obtained immediately after injection of 0.2 mmol/kg contrast material (double dose). The data were analyzed using Fisher's and McNemar tests by SPSS for Windows. Results: Delayed magnetization transfer showed 44 enhanced lesions using magnetization transfer (69.84%) and 29 lesions using T1 (46.03%). In addition, the number of enhanced lesions in the delayed method were significantly more than those in the immediate method (p value=0.003). Conclusion: The use of single dose in combination with magnetization transfer and delayed images after 20-30 minutes enables us to detect more enhanced lesions.

  10. RELAP5/MOD2 blind calculation of GERDA small break test and data comparison

    Ogden, D.M.; Steiner, J.L.; Waterman, M.E.

    1985-01-01

    The Idaho National Engineering Laboratory (INEL), in support of the USNRC, has developed a RELAP5/MOD2 model of the GERDA facility to be used for analysis of the GERDA data, particularly relative to the phenomena of natural circulation and the boiler condenser mode of heat transfer. A blind calculation of GERDA Test 1605AA and a preliminary comparison with experimental data has been performed. The GERDA facility is a single loop integral facility with an electrically heated core. A general arrangement diagram of the facility is shown. The GERDA facility was designed for the performance of both separate effects and overall systems tests

  11. Comparison of theoretical and test results on shear wall seismic response

    Gantenbein, F.; Wang, F.; Dalbera, J.

    1991-01-01

    As reinforced concrete shear walls are important resisting components of buildings in nuclear power facilities, it is important to study their ultimate behavior under dynamic loading. An experimental and analytical work has been undertaken on shear walls with and without openings, in order to develop and validate their model. This paper is related to the walls without openings. While pretest calculations have already been reported (Wang and al. 1989) and the test results are given in Gantenbein and al. 1991, this paper is mainly related to the comparison of test and calculation results on the wall initial stiffness and the time history of the wall motion

  12. Comparison of ORSAT and SCARAB Reentry Analysis Tools for a Generic Satellite Test Case

    Kelley, Robert L.; Hill, Nicole M.; Rochelle, W. C.; Johnson, Nicholas L.; Lips, T.

    2010-01-01

    Reentry analysis is essential to understanding the consequences of the full life cycle of a spacecraft. Since reentry is a key factor in spacecraft development, NASA and ESA have separately developed tools to assess the survivability of objects during reentry. Criteria such as debris casualty area and impact energy are particularly important to understanding the risks posed to people on Earth. Therefore, NASA and ESA have undertaken a series of comparison studies of their respective reentry codes for verification and improvements in accuracy. The NASA Object Reentry Survival Analysis Tool (ORSAT) and the ESA Spacecraft Atmospheric Reentry and Aerothermal Breakup (SCARAB) reentry analysis tools serve as standard codes for reentry survivability assessment of satellites. These programs predict whether an object will demise during reentry and calculate the debris casualty area of objects determined to survive, establishing the reentry risk posed to the Earth's population by surviving debris. A series of test cases have been studied for comparison and the most recent uses "Testsat," a conceptual satellite composed of generic parts, defined to use numerous simple shapes and various materials for a better comparison of the predictions of these two codes. This study is an improvement on the others in this series because of increased consistency in modeling techniques and variables. The overall comparison demonstrated that the two codes arrive at similar results. Either most objects modeled resulted in close agreement between the two codes, or if the difference was significant, the variance could be explained as a case of semantics in the model definitions. This paper presents the main results of ORSAT and SCARAB for the Testsat case and discusses the sources of any discovered differences. Discussion of the results of previous comparisons is made for a summary of differences between the codes and lessons learned from this series of tests.

  13. Compressed Sensing mm-Wave SAR for Non-Destructive Testing Applications Using Multiple Weighted Side Information

    Mathias Becquaert

    2018-05-01

    Full Text Available This work explores an innovative strategy for increasing the efficiency of compressed sensing applied on mm-wave SAR sensing using multiple weighted side information. The approach is tested on synthetic and on real non-destructive testing measurements performed on a 3D-printed object with defects while taking advantage of multiple previous SAR images of the object with different degrees of similarity. The tested algorithm attributes autonomously weights to the side information at two levels: (1 between the components inside the side information and (2 between the different side information. The reconstruction is thereby almost immune to poor quality side information while exploiting the relevant components hidden inside the added side information. The presented results prove that, in contrast to common compressed sensing, good SAR image reconstruction is achieved at subsampling rates far below the Nyquist rate. Moreover, the algorithm is shown to be much more robust for low quality side information compared to coherent background subtraction.

  14. Development test of multiple die with hydraulic compensation and auto lubrication

    Chen Mengyou; Zhang Xichang; Zhu Ninghua; Liu Zichang

    1988-05-01

    Multiple die with hydraulic compensating device adopts the design of multidies gathering in a common grease cavity, using high temperature lubricating grease as the pressure compensating medium. According to Pascal's Law, each die will receive equal pressure during the process of pressing. Such device changes the equi-volume pressing mode of single mechanical die to equipressure pressing mode of multiple die in nuclear fuel element production, thus improves the quality and raises the quantity of nuclear fuel and powder ceramic products, giving a better economic benefit

  15. Identification of Ohnolog Genes Originating from Whole Genome Duplication in Early Vertebrates, Based on Synteny Comparison across Multiple Genomes.

    Singh, Param Priya; Arora, Jatin; Isambert, Hervé

    2015-07-01

    Whole genome duplications (WGD) have now been firmly established in all major eukaryotic kingdoms. In particular, all vertebrates descend from two rounds of WGDs, that occurred in their jawless ancestor some 500 MY ago. Paralogs retained from WGD, also coined 'ohnologs' after Susumu Ohno, have been shown to be typically associated with development, signaling and gene regulation. Ohnologs, which amount to about 20 to 35% of genes in the human genome, have also been shown to be prone to dominant deleterious mutations and frequently implicated in cancer and genetic diseases. Hence, identifying ohnologs is central to better understand the evolution of vertebrates and their susceptibility to genetic diseases. Early computational analyses to identify vertebrate ohnologs relied on content-based synteny comparisons between the human genome and a single invertebrate outgroup genome or within the human genome itself. These approaches are thus limited by lineage specific rearrangements in individual genomes. We report, in this study, the identification of vertebrate ohnologs based on the quantitative assessment and integration of synteny conservation between six amniote vertebrates and six invertebrate outgroups. Such a synteny comparison across multiple genomes is shown to enhance the statistical power of ohnolog identification in vertebrates compared to earlier approaches, by overcoming lineage specific genome rearrangements. Ohnolog gene families can be browsed and downloaded for three statistical confidence levels or recompiled for specific, user-defined, significance criteria at http://ohnologs.curie.fr/. In the light of the importance of WGD on the genetic makeup of vertebrates, our analysis provides a useful resource for researchers interested in gaining further insights on vertebrate evolution and genetic diseases.

  16. Instrumental intelligent test of food sensory quality as mimic of human panel test combining multiple cross-perception sensors and data fusion.

    Ouyang, Qin; Zhao, Jiewen; Chen, Quansheng

    2014-09-02

    Instrumental test of food quality using perception sensors instead of human panel test is attracting massive attention recently. A novel cross-perception multi-sensors data fusion imitating multiple mammal perception was proposed for the instrumental test in this work. First, three mimic sensors of electronic eye, electronic nose and electronic tongue were used in sequence for data acquisition of rice wine samples. Then all data from the three different sensors were preprocessed and merged. Next, three cross-perception variables i.e., color, aroma and taste, were constructed using principal components analysis (PCA) and multiple linear regression (MLR) which were used as the input of models. MLR, back-propagation artificial neural network (BPANN) and support vector machine (SVM) were comparatively used for modeling, and the instrumental test was achieved for the comprehensive quality of samples. Results showed the proposed cross-perception multi-sensors data fusion presented obvious superiority to the traditional data fusion methodologies, also achieved a high correlation coefficient (>90%) with the human panel test results. This work demonstrated that the instrumental test based on the cross-perception multi-sensors data fusion can actually mimic the human test behavior, therefore is of great significance to ensure the quality of products and decrease the loss of the manufacturers. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. Comparison thoracic epidural and intercostal block to improve ventilation parameters and reduce pain in patients with multiple rib fractures.

    Hashemzadeh, Shahryar; Hashemzadeh, Khosrov; Hosseinzadeh, Hamzeh; Aligholipour Maleki, Raheleh; Golzari, Samad E J; Golzari, Samad

    2011-01-01

    Chest wall blunt trauma causes multiple rib fractures and will often be associated with significant pain and may compromise ventilator mechanics. Analgesia has great roll in rib fracture therapies, opioid are useful, but when used as sole agent may require such high dose that they produce respiratory depression, especially in elderly .the best analgesia for a severe chest wall injury is a continuous epidural infusion of local anesthetic. This provides complete analgesia allowing inspiration and coughing without of the risk of respiratory depression. sixty adult patients who with multiple rib fractures were enrolled in this study. They were divided into Group A or thoracic epidural with bupivacaine 0.125 % +1mg/5ml morphine and group B or intercostal block with 0.25% bupivacaine. The patients were assessed through ICU and hospital stay length, ventilation function tests. Pain score among the patients was measured with verbal rating scale, before and after administration of the analgesia. We found a significant improvement in ventilatory function tests during the 1st, 2nd, and 3rd days after epidural analgesia compared with the intercostal block (P pain at rest and pain caused by coughing and deep breathing in group A compared group B... ICU and hospital stay markedly reduced in Group A. thoracic epidural analgesia is superior to intercostals block regarding pain relief of rib fractures. Patients who received epidural analgesia had significantly lower pain scores at all studied times.

  18. Direct comparison of unloading compliance and potential drop techniques in J-integral testing

    McGowan, J.J.; Nanstad, R.K.

    1984-01-01

    Single-specimen J-integral testing is performed commonly with the unloading compliance technique. Use of modern instrumentation techniques and powerful desktop computers have made this technique a standard. However, this testing technique is slow and tedious, with the loading rate fixed at a slow quasi-static rate. For these reasons the dc potential drop technique was investigated for crack length measurement during a J-integral test. For direct comparison, both unloading compliance and potential drop were used simultaneously during a J-integral test. The results showed good agreement between the techniques. However, the potential drop technique showed an offset in crack length due to plastic blunting processes. Taking this offset into account, J/sub Ic/ values calculated by both techniques compared well

  19. Interlaboratory comparison and accreditation in quality control testing of diagnostic X-ray equipment

    Kepler, K.; Vladimirov, A.; Servomaa, A.

    2005-01-01

    The Univ. of Tartu provides a quality control service to the majority of diagnostic X-ray departments in Estonia. Its methodology has been adopted from the IEC and other relevant standards. Recently the Testing Centre of the Univ. of Tartu was accredited on this methodology by ISO/IEC 17025. Besides the implementation of the quality management system, participation in interlaboratory comparison (ILC) was one of the prerequisites for the accreditation. Tests for estimating reproducibility of tube voltage and dose rate, accuracy of the voltage and accuracy of exposure time were carried out on a diagnostic X-ray unit in the Radiation and Nuclear Safety Authority in Helsinki. The measurement performance was judged by calculating deviation En normalised with respect to the stated uncertainties. En values for all tests were less than unity and by the common ILC criteria the testing performance could be considered as acceptable. (authors)

  20. Comparison of grey matter atrophy between patients with neuromyelitis optica and multiple sclerosis: A voxel-based morphometry study

    Duan Yunyun; Liu Yaou; Liang Peipeng; Jia Xiuqin; Yu Chunshui; Qin Wen; Sun Hui; Liao Zhangyuan; Ye Jing; Li Kuncheng

    2012-01-01

    Purpose: Previous studies have established regional grey matter (GM) loss in multiple sclerosis (MS). However, whether there is any regional GM atrophy in neuromyelitis optica (NMO) and the difference between NMO and MS is unclear. The present study addresses this issue by voxel-based morphometry (VBM). Methods: Conventional magnetic resonance imaging (MRI) and T1-weighted three-dimensional MRI were obtained from 26 NMO patients, 26 relapsing–remitting MS (RRMS) patients, and 26 normal controls. An analysis of covariance model assessed with cluster size inference was used to compare GM volume among three groups. The correlations of GM volume changes with disease duration, expanded disability status scale (EDSS) and brain T2 lesion volume (LV) were analyzed. Results: GM atrophy was found in NMO patients in several regions of frontal, temporal, parietal lobes and insula (uncorrected, p < 0.001). While extensive GM atrophy was found in RRMS patients, including most cortical regions and the deep grey matter (corrected for multiple comparisons, p < 0.01). Compared with NMO, those with RRMS had significant GM loss in bilateral thalami, caudate, left parahippocampal gyrus, right hippocampus and insula (corrected, p < 0.01). In RRMS group, regional GM loss in right caudate and bilateral thalami were strongly correlated with brain T2LV. Conclusions: Our study found the difference of GM atrophy between NMO and RRMS patients mainly in deep grey matter. The correlational results suggested axonal degeneration from lesions on T2WI may be a key pathogenesis of atrophy in deep grey matter in RRMS.

  1. Instrumental intelligent test of food sensory quality as mimic of human panel test combining multiple cross-perception sensors and data fusion

    Ouyang, Qin; Zhao, Jiewen; Chen, Quansheng

    2014-01-01

    Highlights: • To develop a novel instrumental intelligent test methodology for food sensory analysis. • A novel data fusion was used in instrumental intelligent test methodology. • Linear and nonlinear tools were comparatively used for modeling. • The instrumental test methodology can be imitative of human test behavior. - Abstract: Instrumental test of food quality using perception sensors instead of human panel test is attracting massive attention recently. A novel cross-perception multi-sensors data fusion imitating multiple mammal perception was proposed for the instrumental test in this work. First, three mimic sensors of electronic eye, electronic nose and electronic tongue were used in sequence for data acquisition of rice wine samples. Then all data from the three different sensors were preprocessed and merged. Next, three cross-perception variables i.e., color, aroma and taste, were constructed using principal components analysis (PCA) and multiple linear regression (MLR) which were used as the input of models. MLR, back-propagation artificial neural network (BPANN) and support vector machine (SVM) were comparatively used for modeling, and the instrumental test was achieved for the comprehensive quality of samples. Results showed the proposed cross-perception multi-sensors data fusion presented obvious superiority to the traditional data fusion methodologies, also achieved a high correlation coefficient (>90%) with the human panel test results. This work demonstrated that the instrumental test based on the cross-perception multi-sensors data fusion can actually mimic the human test behavior, therefore is of great significance to ensure the quality of products and decrease the loss of the manufacturers

  2. Instrumental intelligent test of food sensory quality as mimic of human panel test combining multiple cross-perception sensors and data fusion

    Ouyang, Qin; Zhao, Jiewen; Chen, Quansheng, E-mail: qschen@ujs.edu.cn

    2014-09-02

    Highlights: • To develop a novel instrumental intelligent test methodology for food sensory analysis. • A novel data fusion was used in instrumental intelligent test methodology. • Linear and nonlinear tools were comparatively used for modeling. • The instrumental test methodology can be imitative of human test behavior. - Abstract: Instrumental test of food quality using perception sensors instead of human panel test is attracting massive attention recently. A novel cross-perception multi-sensors data fusion imitating multiple mammal perception was proposed for the instrumental test in this work. First, three mimic sensors of electronic eye, electronic nose and electronic tongue were used in sequence for data acquisition of rice wine samples. Then all data from the three different sensors were preprocessed and merged. Next, three cross-perception variables i.e., color, aroma and taste, were constructed using principal components analysis (PCA) and multiple linear regression (MLR) which were used as the input of models. MLR, back-propagation artificial neural network (BPANN) and support vector machine (SVM) were comparatively used for modeling, and the instrumental test was achieved for the comprehensive quality of samples. Results showed the proposed cross-perception multi-sensors data fusion presented obvious superiority to the traditional data fusion methodologies, also achieved a high correlation coefficient (>90%) with the human panel test results. This work demonstrated that the instrumental test based on the cross-perception multi-sensors data fusion can actually mimic the human test behavior, therefore is of great significance to ensure the quality of products and decrease the loss of the manufacturers.

  3. Free-Suspension Residual Flexibility Testing of Space Station Pathfinder: Comparison to Fixed-Base Results

    Tinker, Michael L.

    1998-01-01

    Application of the free-suspension residual flexibility modal test method to the International Space Station Pathfinder structure is described. The Pathfinder, a large structure of the general size and weight of Space Station module elements, was also tested in a large fixed-base fixture to simulate Shuttle Orbiter payload constraints. After correlation of the Pathfinder finite element model to residual flexibility test data, the model was coupled to a fixture model, and constrained modes and frequencies were compared to fixed-base test. modes. The residual flexibility model compared very favorably to results of the fixed-base test. This is the first known direct comparison of free-suspension residual flexibility and fixed-base test results for a large structure. The model correlation approach used by the author for residual flexibility data is presented. Frequency response functions (FRF) for the regions of the structure that interface with the environment (a test fixture or another structure) are shown to be the primary tools for model correlation that distinguish or characterize the residual flexibility approach. A number of critical issues related to use of the structure interface FRF for correlating the model are then identified and discussed, including (1) the requirement of prominent stiffness lines, (2) overcoming problems with measurement noise which makes the antiresonances or minima in the functions difficult to identify, and (3) the use of interface stiffness and lumped mass perturbations to bring the analytical responses into agreement with test data. It is shown that good comparison of analytical-to-experimental FRF is the key to obtaining good agreement of the residual flexibility values.

  4. Force Concept Inventory-Based Multiple-Choice Test for Investigating Students' Representational Consistency

    Nieminen, Pasi; Savinainen, Antti; Viiri, Jouni

    2010-01-01

    This study investigates students' ability to interpret multiple representations consistently (i.e., representational consistency) in the context of the force concept. For this purpose we developed the Representational Variant of the Force Concept Inventory (R-FCI), which makes use of nine items from the 1995 version of the Force Concept Inventory…

  5. Examining the Prediction of Reading Comprehension on Different Multiple-Choice Tests

    Andreassen, Rune; Braten, Ivar

    2010-01-01

    In this study, 180 Norwegian fifth-grade students with a mean age of 10.5 years were administered measures of word recognition skills, strategic text processing, reading motivation and working memory. Six months later, the same students were given three different multiple-choice reading comprehension measures. Based on three forced-order…

  6. Qualification of new design of flexible pipe against singing: testing at multiple scales

    Golliard, J.; Lunde, K.; Vijlbrief, O.

    2016-01-01

    Flexible pipes for production of oil and gas typically present a corrugated inner surface. This has been identified as the cause of "singing risers": Flow-Induced Pulsations due to the interaction of sound waves with the shear layers at the small cavities present at each of the multiple

  7. Retrieval practice with short-answer, multiple-choice, and hybrid tests.

    Smith, Megan A; Karpicke, Jeffrey D

    2014-01-01

    Retrieval practice improves meaningful learning, and the most frequent way of implementing retrieval practice in classrooms is to have students answer questions. In four experiments (N=372) we investigated the effects of different question formats on learning. Students read educational texts and practised retrieval by answering short-answer, multiple-choice, or hybrid questions. In hybrid conditions students first attempted to recall answers in short-answer format, then identified answers in multiple-choice format. We measured learning 1 week later using a final assessment with two types of questions: those that could be answered by recalling information verbatim from the texts and those that required inferences. Practising retrieval in all format conditions enhanced retention, relative to a study-only control condition, on both verbatim and inference questions. However, there were little or no advantages of answering short-answer or hybrid format questions over multiple-choice questions in three experiments. In Experiment 4, when retrieval success was improved under initial short-answer conditions, there was an advantage of answering short-answer or hybrid questions over multiple-choice questions. The results challenge the simple conclusion that short-answer questions always produce the best learning, due to increased retrieval effort or difficulty, and demonstrate the importance of retrieval success for retrieval-based learning activities.

  8. Adaptation of eddy current methods to the multiple problems of reactor testing

    Stumm, W.

    1975-01-01

    In reactor testing, the eddy current method is mainly used for the testing of surface regions inside the pressure vessel, on welds and joints, and for the testing of thin-walled pipes, e.g. the heat exchanger pipes. (RW/AK) [de

  9. A Sequential Circuit-Based IP Watermarking Algorithm for Multiple Scan Chains in Design-for-Test

    C. Wu

    2011-06-01

    Full Text Available In Very Large Scale Integrated Circuits (VLSI design, the existing Design-for-Test(DFT based watermarking techniques usually insert watermark through reordering scan cells, which causes large resource overhead, low security and coverage rate of watermark detection. A novel scheme was proposed to watermark multiple scan chains in DFT for solving the problems. The proposed scheme adopts DFT scan test model of VLSI design, and uses a Linear Feedback Shift Register (LFSR for pseudo random test vector generation. All of the test vectors are shifted in scan input for the construction of multiple scan chains with minimum correlation. Specific registers in multiple scan chains will be changed by the watermark circuit for watermarking the design. The watermark can be effectively detected without interference with normal function of the circuit, even after the chip is packaged. The experimental results on several ISCAS benchmarks show that the proposed scheme has lower resource overhead, probability of coincidence and higher coverage rate of watermark detection by comparing with the existing methods.

  10. Comparison of Multiple Linear Regressions and Neural Networks based QSAR models for the design of new antitubercular compounds.

    Ventura, Cristina; Latino, Diogo A R S; Martins, Filomena

    2013-01-01

    The performance of two QSAR methodologies, namely Multiple Linear Regressions (MLR) and Neural Networks (NN), towards the modeling and prediction of antitubercular activity was evaluated and compared. A data set of 173 potentially active compounds belonging to the hydrazide family and represented by 96 descriptors was analyzed. Models were built with Multiple Linear Regressions (MLR), single Feed-Forward Neural Networks (FFNNs), ensembles of FFNNs and Associative Neural Networks (AsNNs) using four different data sets and different types of descriptors. The predictive ability of the different techniques used were assessed and discussed on the basis of different validation criteria and results show in general a better performance of AsNNs in terms of learning ability and prediction of antitubercular behaviors when compared with all other methods. MLR have, however, the advantage of pinpointing the most relevant molecular characteristics responsible for the behavior of these compounds against Mycobacterium tuberculosis. The best results for the larger data set (94 compounds in training set and 18 in test set) were obtained with AsNNs using seven descriptors (R(2) of 0.874 and RMSE of 0.437 against R(2) of 0.845 and RMSE of 0.472 in MLRs, for test set). Counter-Propagation Neural Networks (CPNNs) were trained with the same data sets and descriptors. From the scrutiny of the weight levels in each CPNN and the information retrieved from MLRs, a rational design of potentially active compounds was attempted. Two new compounds were synthesized and tested against M. tuberculosis showing an activity close to that predicted by the majority of the models. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  11. Defining key features of the broad autism phenotype: a comparison across parents of multiple- and single-incidence autism families.

    Losh, Molly; Childress, Debra; Lam, Kristen; Piven, Joseph

    2008-06-05

    This study examined the frequency of personality, language, and social-behavioral characteristics believed to comprise the broad autism phenotype (BAP), across families differing in genetic liability to autism. We hypothesized that within this unique sample comprised of multiple-incidence autism families (MIAF), single-incidence autism families (SIAF), and control Down syndrome families (DWNS), a graded expression would be observed for the principal characteristics conferring genetic susceptibility to autism, in which such features would express most profoundly among parents from MIAFs, less strongly among SIAFs, and least of all among comparison parents from DWNS families, who should display population base rates. Analyses detected linear expression of traits in line with hypotheses, and further suggested differential intrafamilial expression across family types. In the vast majority of MIAFs both parents displayed BAP characteristics, whereas within SIAFs, it was equally likely that one, both, or neither parent show BAP features. The significance of these findings is discussed in relation to etiologic mechanisms in autism and relevance to molecular genetic studies. (c) 2007 Wiley-Liss, Inc.

  12. Cost comparison between private and public collection of residual household waste: multiple case studies in the Flemish region of Belgium.

    Jacobsen, R; Buysse, J; Gellynck, X

    2013-01-01

    The rising pressure in terms of cost efficiency on public services pushes governments to transfer part of those services to the private sector. A trend towards more privatizing can be noticed in the collection of municipal household waste. This paper reports the findings of a research project aiming to compare the cost between the service of private and public collection of residual household waste. Multiple case studies of municipalities about the Flemish region of Belgium were conducted. Data concerning the year 2009 were gathered through in-depth interviews in 2010. In total 12 municipalities were investigated, divided into three mutual comparable pairs with a weekly and three mutual comparable pairs with a fortnightly residual waste collection. The results give a rough indication that in all cases the cost of private service is lower than public service in the collection of household waste. Albeit that there is an interest in establishing whether there are differences in the costs and service levels between public and private waste collection services, there are clear difficulties in establishing comparisons that can be made without having to rely on a large number of assumptions and corrections. However, given the cost difference, it remains the responsibility of the municipalities to decide upon the service they offer their citizens, regardless the cost efficiency: public or private. Copyright © 2012 Elsevier Ltd. All rights reserved.

  13. Multiple sclerosis test or the 4 humors: cerebrospinal fluid serum, tears and saliva

    Oehninger Gatti, C.; Buzo Del Puerto, R.; Chouza Antelo, C.; Scotti Bianchi, C.; Cibils, D.; Alcantara Pelaez, J.; Gomez, A.; Heuguerot Oliveira, C.

    1994-01-01

    4 were studied biological fluids easily accessible to the immune exploration (cerebrospinal fluid, serum, tears and saliva) in 25 patients with Multiple Sclerosis (MS) during a push clinical disease. The level of interleukin-2 receptor soluble (RsIL-2) was significantly increased by at least 3 of these 4 fluids, compared with normal controls. The sensitivity and specificity of its determination for the diagnosis of the condition was higher than other immunochemical parameters, oligoclonal distribution (OD) of immunoglobulin (Ig) light chain imbalance-and-evoked electrophysiological studies. This method is used to establish a more accurate diagnosis of Multiple Sclerosis as well as to monitor its biological activity with nuclear magnetic resonance (NMR) (Author) [es

  14. PERMANOVA-S: association test for microbial community composition that accommodates confounders and multiple distances

    Tang, Zheng-Zheng; Chen, Guanhua; Alekseyenko, Alexander V.

    2016-01-01

    Motivation: Recent advances in sequencing technology have made it possible to obtain high-throughput data on the composition of microbial communities and to study the effects of dysbiosis on the human host. Analysis of pairwise intersample distances quantifies the association between the microbiome diversity and covariates of interest (e.g. environmental factors, clinical outcomes, treatment groups). In the design of these analyses, multiple choices for distance metrics are available. Most di...

  15. Specification and testing of Multiplicative Time-Varying GARCH models with applications

    Amado, Cristina; Teräsvirta, Timo

    2017-01-01

    In this article, we develop a specification technique for building multiplicative time-varying GARCH models of Amado and Teräsvirta (2008, 2013). The variance is decomposed into an unconditional and a conditional component such that the unconditional variance component is allowed to evolve smooth...... is illustrated in practice with two real examples: an empirical application to daily exchange rate returns and another one to daily coffee futures returns....

  16. Assessment of Dermatoglyphics Multiple Intelligence Test (DMIT Reports: Implication to Career Guidance Program Enhancement of Academic Institutions

    Dr. Maria Luisa A. Valdez

    2014-04-01

    Full Text Available This research aims to assess the reports generated from the Dermatoglyphics Multiple Intelligence Test (DMIT administered by selected DMIT resource companies and consultancy firms in India with the end view of identifying its implication to career guidance program enhancement of academic institutions. This paper employed the descriptive research method which involved the use of documentary analysis, questionnaires and interviews with purposively selected respondents supported by the researchers’ analysis and insights with reference to the content of the data. Findings of this research revealed that the dermatoglyphics, as a scientific discipline, began with the publication of Purkinje’s thesis (1823 and Galton’s classic book, Fingerprints (1892; DMIT is a remarkable offshoot of Howard Gardner’s Theory of Multiple Intelligences which has the following salient features: Overview of the Dermatoglyphics and the Dermatoglyphics Multiple Intelligence Test/Analysis; Personality Assessment; Profile based on Gardner’s Multiple Intelligences and Dunn’s Brain Lateralization Theories; Learning Styles; Competency and Compatibility Profiles; Working Style; Leadership Style; Management Style; Report Interpretation; and Customized Academic and Relationship Advises; the respondents of this study gave their perceptions with reference to the beneficial results of the DMIT; and the foregoing findings have some implications that may be used by academic institutions to enhance their career guidance program.

  17. An Efficient Stepwise Statistical Test to Identify Multiple Linked Human Genetic Variants Associated with Specific Phenotypic Traits.

    Iksoo Huh

    Full Text Available Recent advances in genotyping methodologies have allowed genome-wide association studies (GWAS to accurately identify genetic variants that associate with common or pathological complex traits. Although most GWAS have focused on associations with single genetic variants, joint identification of multiple genetic variants, and how they interact, is essential for understanding the genetic architecture of complex phenotypic traits. Here, we propose an efficient stepwise method based on the Cochran-Mantel-Haenszel test (for stratified categorical data to identify causal joint multiple genetic variants in GWAS. This method combines the CMH statistic with a stepwise procedure to detect multiple genetic variants associated with specific categorical traits, using a series of associated I × J contingency tables and a null hypothesis of no phenotype association. Through a new stratification scheme based on the sum of minor allele count criteria, we make the method more feasible for GWAS data having sample sizes of several thousands. We also examine the properties of the proposed stepwise method via simulation studies, and show that the stepwise CMH test performs better than other existing methods (e.g., logistic regression and detection of associations by Markov blanket for identifying multiple genetic variants. Finally, we apply the proposed approach to two genomic sequencing datasets to detect linked genetic variants associated with bipolar disorder and obesity, respectively.

  18. Integrating Multiple On-line Knowledge Bases for Disease-Lab Test Relation Extraction.

    Zhang, Yaoyun; Soysal, Ergin; Moon, Sungrim; Wang, Jingqi; Tao, Cui; Xu, Hua

    2015-01-01

    A computable knowledge base containing relations between diseases and lab tests would be a great resource for many biomedical informatics applications. This paper describes our initial step towards establishing a comprehensive knowledge base of disease and lab tests relations utilizing three public on-line resources. LabTestsOnline, MedlinePlus and Wikipedia are integrated to create a freely available, computable disease-lab test knowledgebase. Disease and lab test concepts are identified using MetaMap and relations between diseases and lab tests are determined based on source-specific rules. Experimental results demonstrate a high precision for relation extraction, with Wikipedia achieving the highest precision of 87%. Combining the three sources reached a recall of 51.40%, when compared with a subset of disease-lab test relations extracted from a reference book. Moreover, we found additional disease-lab test relations from on-line resources, indicating they are complementary to existing reference books for building a comprehensive disease and lab test relation knowledge base.

  19. Comparison of infrared and 3D digital image correlation techniques applied for mechanical testing of materials

    Krstulović-Opara, Lovre; Surjak, Martin; Vesenjak, Matej; Tonković, Zdenko; Kodvanj, Janoš; Domazet, Željko

    2015-11-01

    To investigate the applicability of infrared thermography as a tool for acquiring dynamic yielding in metals, a comparison of infrared thermography with three dimensional digital image correlation has been made. Dynamical tension tests and three point bending tests of aluminum alloys have been performed to evaluate results obtained by IR thermography in order to detect capabilities and limits for these two methods. Both approaches detect pastification zone migrations during the yielding process. The results of the tension test and three point bending test proved the validity of the IR approach as a method for evaluating the dynamic yielding process when used on complex structures such as cellular porous materials. The stability of the yielding process in the three point bending test, as contrary to the fluctuation of the plastification front in the tension test, is of great importance for the validation of numerical constitutive models. The research proved strong performance, robustness and reliability of the IR approach when used to evaluate yielding during dynamic loading processes, while the 3D DIC method proved to be superior in the low velocity loading regimes. This research based on two basic tests, proved the conclusions and suggestions presented in our previous research on porous materials where middle wave infrared thermography was applied.

  20. Estimates of lay views about reversal multiple intelligences for self and others: Sex and cross-cultural comparisons.

    Neto, Félix; da Conceição Pinto, Maria; Mullet, Etienne; Furnham, Adrian

    2017-12-01

    This study focuses on lay conceptions of intelligence. It examined sex and cross-cultural similarities and differences in estimated intelligences and beliefs about intelligence in two countries, Angola and East Timor, within the reversal theory framework. A total of 209 Angolan (109 women and 100 men) and 183 Timorese (89 women and 94 men) students were participated in this study. Participants completed a questionnaire in order to estimate their parents', partners' and own overall intelligence and the 8 reversal multiple intelligences (telic, paratelic, conformist, negativistic, autic mastery, autic sympathy, alloic mastery and alloic sympathy intelligence). Respondents also rated 6 questions about intelligence. Men rated their overall, conformist and autic mastery higher than women. Angolans rated their overall, telic, paratelic, conformist, negativistic, autic mastery, autic sympathy, alloic mastery and alloic sympathy intelligence higher than Timorese. In both countries, fathers have been perceived as more intelligent than mothers, and telic intelligence emerged as a significant predictor of overall intelligence. Principal component analysis of the 8 reversal multiple intelligences yielded one factor. Angolan participants revealed more IQ test experience than Timorese participants. Most of respondents in both countries did not believe in sex differences in intelligence. These findings are discussed by means of cross-cultural literature. © 2015 International Union of Psychological Science.

  1. Evaluating the Psychometric Characteristics of Generated Multiple-Choice Test Items

    Gierl, Mark J.; Lai, Hollis; Pugh, Debra; Touchie, Claire; Boulais, André-Philippe; De Champlain, André

    2016-01-01

    Item development is a time- and resource-intensive process. Automatic item generation integrates cognitive modeling with computer technology to systematically generate test items. To date, however, items generated using cognitive modeling procedures have received limited use in operational testing situations. As a result, the psychometric…

  2. Validation of a Standardized Multiple-Choice Multicultural Competence Test: Implications for Training, Assessment, and Practice

    Gillem, Angela R.; Bartoli, Eleonora; Bertsch, Kristin N.; McCarthy, Maureen A.; Constant, Kerra; Marrero-Meisky, Sheila; Robbins, Steven J.; Bellamy, Scarlett

    2016-01-01

    The Multicultural Counseling and Psychotherapy Test (MCPT), a measure of multicultural counseling competence (MCC), was validated in 2 phases. In Phase 1, the authors administered 451 test items derived from multicultural guidelines in counseling and psychology to 32 multicultural experts and 30 nonexperts. In Phase 2, the authors administered the…

  3. A Browser-Server-Based Tele-audiology System That Supports Multiple Hearing Test Modalities.

    Yao, Jianchu Jason; Yao, Daoyuan; Givens, Gregg

    2015-09-01

    Millions of global citizens suffering from hearing disorders have limited or no access to much needed hearing healthcare. Although tele-audiology presents a solution to alleviate this problem, existing remote hearing diagnosis systems support only pure-tone tests, leaving speech and other test procedures unsolved, due to the lack of software and hardware to enable communication required between audiologists and their remote patients. This article presents a comprehensive remote hearing test system that integrates the two most needed hearing test procedures: a pure-tone audiogram and a speech test. This enhanced system is composed of a Web application server, an embedded smart Internet-Bluetooth(®) (Bluetooth SIG, Kirkland, WA) gateway (or console device), and a Bluetooth-enabled audiometer. Several graphical user interfaces and a relational database are hosted on the application server. The console device has been designed to support the tests and auxiliary communication between the local site and the remote site. The study was conducted at an audiology laboratory. Pure-tone audiogram and speech test results from volunteers tested with this tele-audiology system are comparable with results from the traditional face-to-face approach. This browser-server-based comprehensive tele-audiology offers a flexible platform to expand hearing services to traditionally underserved groups.

  4. Memory-Context Effects of Screen Color in Multiple-Choice and Fill-In Tests

    Prestera, Gustavo E.; Clariana, Roy; Peck, Andrew

    2005-01-01

    In this experimental study, 44 undergraduates completed five computer-based instructional lessons and either two multiplechoice tests or two fill-in-the-blank tests. Color-coded borders were displayed during the lesson, adjacent to the screen text and illustrations. In the experimental condition, corresponding border colors were shown at posttest.…

  5. Practice effect in Symbol Digit Modalities Test in multiple sclerosis patients treated with natalizumab

    Roar Eriksen, Malte; Illes, Zsolt; Sejbaek, Tobias

    2016-01-01

    OBJECTIVES: How practice effect influences cognitive testing measured by monthly Symbol Digit Modalities Test (SDMT) during natalizumab treatment, and what factors confound such effect. METHODS: Eighty patients were examined monthly with SDMT for 26.2±8.4 months. After 26.0±8.1 months, SDMT...... and the rearranged key, respectively. We also explored if natalizumab applied before regular monthly SDMT may influence practice effect and cognition. RESULTS: SDMT performance improved by 1.2 points/test during the first six months and by 0.4 points/test thereafter. Rearranging the symbols of the key after 26.......0±8.1 months returned SDMT scores to baseline indicating a practice effect. Such practice effect was more significant after longer testing period, but was not influenced by gender, age, relapses, disability progression and prior natalizumab treatment. Although the change from baseline to 2.5 years...

  6. Multiloop integral system test (MIST): Final report, Inter-group comparisons

    Gloudemans, J.R.

    1989-07-01

    The multiloop integral system test (MIST) was part of a multiphase program started in 1983 to address small-break loss-of-coolant accidents (SBLOCAs) specific to Babcock and Wilcox-designed plants. MIST was sponsored by the US Nuclear Regulatory Commission, the Babcock and Wilcox Owners Group, the Electric Power Research Institute, and Babcock and Wilcox. The unique features of the Babcock and Wilcox design, specifically the hot leg U-bends and steam generators, prevented the use of existing integral system data or existing integral system facilities to address the thermal-hydraulic SBLOCA questions. MIST and two other supporting facilities were specifically designed and constructed for this program, and an existing facility -- the once-through integral system (OTIS) -- was also used. Data from MIST and the other facilities will be used to benchmark the adequacy of system codes, such as RELAP5 and TRAC, for predicting abnormal plant transients. The individual tests are described in detail in Volumes 2 through 8 and Volume 11, and are summarized in Volume 1. Inter-group comparisons are addressed in this document, Volume 9. These comparisons are grouped as follows: mapping versus SBLOCA transients, SBLOCA, pump effects, and the effects of noncondensible gases. Appendix A provides an index and description of the microfiched plots for each test, which are enclosed with the corresponding Volumes 2 through 8. 147 figs., 5 tabs.

  7. Performance, usability and comparison of two versions of a new macular vision test: the handheld Radial Shape Discrimination test

    Jae Y. Ku

    2016-11-01

    also observed no statistically significant difference between 3AFC (−0.82 ± 0.11 logMAR and 4AFC (−0.80 ± 0.12 logMAR hRSD thresholds (t = 1.85, p = 0.067 and participants reported excellent test usability with no strong preference expressed between the 3AFC and 4AFC versions of the test. Discussion The 3AFC hRSD thresholds we report are consistent with a number of previous studies, as is its greater stability in ageing compared to VA. We have also shown that in the absence of pathology, thresholds are stable over short and long timescales. The 4AFC thresholds we have reported provide a baseline for future investigations, and we have confirmed that 3AFC and 4AFC thresholds are similar, providing a basis of comparisons between studies using the different versions. As the hRSD test is easy to use and relatively inexpensive, clinical studies are now required to establish its ability to detect and monitor macular pathologies.

  8. Comparison of Aerobic Performance Testing Protocols in Elite Male Wheelchair Basketball Players

    Molik Bartosz

    2017-12-01

    Full Text Available In wheelchair sports, aerobic performance is commonly assessed with the use of an arm crank ergometer (ACE, a wheelchair ergometer (WCE or a wheelchair treadmill (WCT. There are different protocols to identify peak oxygen uptake in wheelchair sports; however, only a few protocols have been applied to evaluate these conditions in wheelchair basketball players. The purpose of this study was to compare physiological responses during maximal exercise testing with the use of ACE and WCT in wheelchair basketball players. Twelve elite male wheelchair basketball players participated in this study. The research was performed during a training camp of the Polish National Wheelchair Basketball Team. The study participants were divided into two functional categories: A (players with class 1.0 - 2.5 and B (players with class 3.0 - 4.5. Two main maximal exercise tests, i.e. wheelchair treadmill stress test (WCT test and arm crank ergometer stress test (ACE test were used to evaluate aerobic performance of the players. There were no statistically significant differences in aerobic tests between the players from both groups. The comparison of results achieved in two aerobic tests performed on WCT and ACE did not reveal any significant differences between the analyzed variables (peak heart rate (HRpeak, peak oxygen uptake (VO2peak, minute ventilation (VE, anaerobic threshold (AT, lactate concentration (LApeak, and a drop in lactate concentration (%LA. Strong correlations between results achieved in WCT and ACE tests were found for VO2peak, VE and LApeak. The main conclusion of the study is that both WCT and ACE tests may be useful when determining aerobic capacity of wheelchair basketball players. Moreover, both protocols can be used by athletes regardless of their functional capabilities and types of impairment.

  9. Comparison Thoracic Epidural and Intercostal Block to Improve Ventilation Parameters and Reduce Pain in Patients with Multiple Rib Fractures

    Raheleh Aligholipour Maleki

    2011-08-01

    Full Text Available Introduction: Chest wall blunt trauma causes multiple rib fractures and will often be associated with significant pain and may compromise ventilator mechanics. Analgesia has great roll in rib fracture therapies, opioid are useful, but when used as sole agent may re-quire such high dose that they produce respiratory depression, especially in el-derly .the best analgesia for a severe chest wall injury is a continuous epidural infusion of local anesthetic. This provides complete analgesia allowing inspiration and coughing without of the risk of respiratory depression. Methods: sixty adult patients who with multiple rib fractures were enrolled in this study. They were divided into Group A or thoracic epidural with bupivacaine 0.125 % +1mg/5ml morphine and group B or inter-costal block with %0.25 bupivacaine. The patients were assessed through ICU and hos-pital stay length, ventilation function tests. Pain score among the patients was meas-ured with verbal rating scale, before and after administration of the analgesia. Results: We found a significant improvement in ventilatory function tests during the 1st, 2nd, and 3rd days after epidural analgesia compared with the intercostal block (P < 0.004. Changes in the visual Analogue Scale were associated with marked improvement re-garding pain at rest and pain caused by coughing and deep breathing in group A com-pared group B... ICU and hospital stay markedly reduced in Group A. Conclusion: tho-racic epidural analgesia is superior to intercostals block regarding pain relief of rib frac-tures. Patients who received epidural analgesia had significantly lower pain scores at all studied times.

  10. Comparison of MRI sequences for evaluation of multiple sclerosis of the cervical spinal cord at 3 T

    Philpott, Cristina; Brotchie, Peter

    2011-01-01

    Purpose: Debate remains regarding the utility of the traditional STIR (short inversion time recovery) sequence in aiding MRI diagnosis of spinal cord lesions in patients with multiple sclerosis (MS) and this sequence is not included in the current imaging guidelines. A recent study proposed a T1 weighted STIR as a superior alternative to the traditional STIR and T2 fast spin echo (FSE). Thus, the aim of this study was to compare the sensitivity of T2, standard STIR and T1 weighted STIR sequences in the evaluation of MS plaques on our 3 T system. Methods and materials: A retrospective analysis of patients with multiple sclerosis who presented to our institution over a period of 5 months and who had cervical cord lesions was undertaken. Patients had been examined with our institutional protocol which included T2 FSE, STIR and the recommended T1 STIR. Quantitative analysis of the lesions versus background cord using sample T-tests was performed for each sequence, and comparative analysis of the lesion contrast:background cord ratios of the 3 sequences (using two-way ANOVA tests) was performed. Results: The T2 sequence was not as sensitive in detecting lesions versus the traditional STIR and T1 weighted STIR, with 10% of lesions not detected using statistical analysis (p < 0.05). The traditional STIR also demonstrated greater contrast ratios than the T2 sequence (p < 0.05) suggesting increased sensitivity. However, the T1 STIR demonstrated even greater contrast ratios than both the traditional STIR and T2 sequences (p < 0.05). Conclusion: This study confirms earlier findings of the traditional STIRs increased sensitivity versus the T2 sequence. However, the new “T1 weighted STIR” appears to be even more sensitive than both these sequences showing potential promise as an alternative method to monitor demyelinating plaques of MS.

  11. Studying different tasks of implicit learning across multiple test sessions conducted on the web

    Werner eSævland

    2016-06-01

    Full Text Available Implicit learning is usually studied through individual performance on a single task, with the most common tasks being Serial Reaction Time task (SRT; Nissen and Bullemer, 1987, Dynamic System Control task (DSC; (Berry and Broadbent, 1984 and artificial Grammar Learning task (AGL; (Reber, 1967. Few attempts have been made to compare performance across different implicit learning tasks within the same experiment. The current experiment was designed study the relationship between performance on the DSC Sugar factory task (Berry and Broadbent, 1984 and the Alternating Serial Reaction Time task (ASRT; (Howard and Howard, 1997. We also addressed another limitation to traditional implicit learning experiments, namely that implicit learning is usually studied in laboratory settings over a restricted time span lasting for less than an hour (Berry and Broadbent, 1984; Nissen and Bullemer, 1987; Reber, 1967. In everyday situations, implicit learning is assumed to involve a gradual accumulation of knowledge across several learning episodes over a larger time span (Norman and Price, 2012. One way to increase the ecological validity of implicit learning experiments could be to present the learning material repeatedly across shorter experimental sessions (Howard and Howard, 1997; Cleeremans and McClelland, 1991. This can most easily be done by using a web-based setup that participants can access from home. We therefore created an online web-based system for measuring implicit learning that could be administered in either single or multiple sessions. Participants (n = 66 were assigned to either a single-session or a multi-session condition. Learning and the degree of conscious awareness of the learned regularities was compared across condition (single vs. multiple sessions and tasks (DSC vs. ASRT. Results showed that learning on the two tasks was not related. However, participants in the multiple sessions condition did show greater improvements in reaction

  12. Comparison of three flaw-location methods for automated ultrasonic testing

    Seiger, H.

    1982-01-01

    Two well-known methods for locating flaws by measurement of the transit time of ultrasonic pulses are examined theoretically. It is shown that neither is sufficiently reliable for use in automated ultrasonic testing. A third method, which takes into account the shape of the sound field from the probe and the uncertainty in measurement of probe-flaw distance and probe position, is introduced. An experimental comparison of the three methods indicates that use of the advanced method results in more accurate location of flaws. (author)

  13. Method for aquatic multiple species toxicant testing: acute toxicity of 10 chemicals to 5 vertebrates and 2 invertebrates. [Pimephales promelas; Carassius auratus; Ictalurus punctatus; Lepomis macrochirus; Salmo gairdneri; Orconectes immunis; Aplexa hypnorum

    Phipps, G.L.; Holcombe, G.W.

    1985-01-01

    A method was developed to simultaneously ascertain 96 h LC/sub 50/ values for seven freshwater species in a single flow through test with measured concentrations. It allows interspecific comparisons, easy determination of the most sensitive species, and cuts cost of labor, materials and chemical analysis for measured concentration tests. Species tested included fathead minnows Pimephales promelas, goldfish Carassius auratus, channel catfish Ictalurus punctatus, bluegill Lepomis macrochirus, rainbow trout Salmo gairdneri, crayfish Orconectes immunis and snails Aplexa hypnorum. Compounds tested were pentachlorophenol, 2-chloroethanol, 2,4-pentanedione, hexachloroethane, ..cap alpha..-bromo-2',5'-dimethoxyacetophenone, benzaldehyde, 1,3-dichloro-4,6-dinitro-benzene, dursban, sevin and cadmium chloride. The LC/sub 50/ values from these multiple species tests compared favourably with those determined using single species tests at this laboratory, usually within 20%.

  14. Comparison of Numerical Analyses with a Static Load Test of a Continuous Flight Auger Pile

    Hoľko, Michal; Stacho, Jakub

    2014-12-01

    The article deals with numerical analyses of a Continuous Flight Auger (CFA) pile. The analyses include a comparison of calculated and measured load-settlement curves as well as a comparison of the load distribution over a pile's length. The numerical analyses were executed using two types of software, i.e., Ansys and Plaxis, which are based on FEM calculations. Both types of software are different from each other in the way they create numerical models, model the interface between the pile and soil, and use constitutive material models. The analyses have been prepared in the form of a parametric study, where the method of modelling the interface and the material models of the soil are compared and analysed. Our analyses show that both types of software permit the modelling of pile foundations. The Plaxis software uses advanced material models as well as the modelling of the impact of groundwater or overconsolidation. The load-settlement curve calculated using Plaxis is equal to the results of a static load test with a more than 95 % degree of accuracy. In comparison, the load-settlement curve calculated using Ansys allows for the obtaining of only an approximate estimate, but the software allows for the common modelling of large structure systems together with a foundation system.

  15. Comparison of constant-rate pumping test and slug interference test results at the Hanford Site B pond multilevel test facility

    Spane, F.A. Jr.; Thorne, P.D.

    1995-10-01

    Pacific Northwest Laboratory (PNL), as part of the Hanford Site Ground-Water Surveillance Project, is responsible for monitoring the movement and fate of contamination within the unconfined aquifer to ensure that public health and the environment are protected. To support the monitoring and assessment of contamination migration on the Hanford Site, a sitewide 3-dimensional groundwater flow model is being developed. Providing quantitative hydrologic property data is instrumental in development of the 3-dimensional model. Multilevel monitoring facilities have been installed to provide detailed, vertically distributed hydrologic characterization information for the Hanford Site unconfined aquifer. In previous reports, vertically distributed water-level and hydrochemical data obtained over time from these multi-level monitoring facilities have been evaluated and reported. This report describes the B pond facility in Section 2.0. It also provides analysis results for a constant-rate pumping test (Section 3.0) and slug interference test (Section 4.0) that were conducted at a multilevel test facility located near B Pond (see Figure 1. 1) in the central part of the Hanford Site. A hydraulic test summary (Section 5.0) that focuses on the comparison of hydraulic property estimates obtained using the two test methods is also presented. Reference materials are listed in Section 6.0

  16. A multiple-well method for immunohistochemical testing of many reagents on a single microscopic slide.

    McKeever, P E; Letica, L H; Shakui, P; Averill, D R

    1988-09-01

    Multiple wells (M-wells) have been made over tissue sections on single microscopic slides to simultaneously localize binding specificity of many antibodies. More than 20 individual 4-microliter wells over tissue have been applied/slide, representing more than a 5-fold improvement in wells/slide and a 25-fold reduction in reagent volume over previous methods. More than 30 wells/slide have been applied over cellular monolayers. To produce the improvement, previous strategies of placing specimens into wells were changed to instead create wells over the specimen. We took advantage of the hydrophobic properties of paint to surround the wells and to segregate the various different primary antibodies. Segregation was complete on wells alternating with and without primary monoclonal antibody. The procedure accommodates both frozen and paraffin sections, yielding slides which last more than a year. After monoclonal antibody detection, standard histologic stains can be applied as counterstains. M-wells are suitable for localizing binding of multiple reagents or sample unknowns (polyclonal or monoclonal antibodies, hybridoma supernatants, body fluids, lectins) to either tissues or cells. Their small sample volume and large number of sample wells/slide could be particularly useful for early screening of hybridoma supernatants and for titration curves in immunohistochemistry (McKeever PE, Shakui P, Letica LH, Averill DR: J Histochem Cytochem 36:931, 1988).

  17. Results of a diesel multiple unit fuel tank blunt impact test

    2017-04-04

    The Federal Railroad Administrations Office of Research and Development is conducting research into passenger locomotive fuel tank crashworthiness. A series of impact tests is being conducted to measure fuel tank deformation under two types of dyn...

  18. A higher-order generalized singular value decomposition for comparison of global mRNA expression from multiple organisms.

    Sri Priya Ponnapalli

    Full Text Available The number of high-dimensional datasets recording multiple aspects of a single phenomenon is increasing in many areas of science, accompanied by a need for mathematical frameworks that can compare multiple large-scale matrices with different row dimensions. The only such framework to date, the generalized singular value decomposition (GSVD, is limited to two matrices. We mathematically define a higher-order GSVD (HO GSVD for N≥2 matrices D(i∈R(m(i × n, each with full column rank. Each matrix is exactly factored as D(i=U(iΣ(iV(T, where V, identical in all factorizations, is obtained from the eigensystem SV=VΛ of the arithmetic mean S of all pairwise quotients A(iA(j(-1 of the matrices A(i=D(i(TD(i, i≠j. We prove that this decomposition extends to higher orders almost all of the mathematical properties of the GSVD. The matrix S is nondefective with V and Λ real. Its eigenvalues satisfy λ(k≥1. Equality holds if and only if the corresponding eigenvector v(k is a right basis vector of equal significance in all matrices D(i and D(j, that is σ(i,k/σ(j,k=1 for all i and j, and the corresponding left basis vector u(i,k is orthogonal to all other vectors in U(i for all i. The eigenvalues λ(k=1, therefore, define the "common HO GSVD subspace." We illustrate the HO GSVD with a comparison of genome-scale cell-cycle mRNA expression from S. pombe, S. cerevisiae and human. Unlike existing algorithms, a mapping among the genes of these disparate organisms is not required. We find that the approximately common HO GSVD subspace represents the cell-cycle mRNA expression oscillations, which are similar among the datasets. Simultaneous reconstruction in the common subspace, therefore, removes the experimental artifacts, which are dissimilar, from the datasets. In the simultaneous sequence-independent classification of the genes of the three organisms in this common subspace, genes of highly conserved sequences but significantly different cell

  19. Instrumentation, control and data acquisition system with multiple configurations for test in nuclear environment

    Monti, Chiara, E-mail: chiara.monti@enea.it; Neri, Carlo; Pollastrone, Fabio

    2015-10-15

    Highlights: • ENEA developed and characterized a first prototype of the In-Vessel Viewing System (IVVS) probe for ITER. • Piezo motor technology to be used in IVVS probe was tested in neutrons, gamma radiations, high temperature, vacuum and high magnetic fields. • A general architecture of the Data Acquisition and Control System (DACS) was defined and then specialized for each test. • The test campaign has validated instrumentation solutions, which can be effectively used in final IVVS implementation or other ITER diagnostics or applications. - Abstract: The In-Vessel Viewing System is a 3D laser scanning system which will be used to inspect the blanket first wall in ITER. To make the IVVS probe design compatible with the harsh environmental conditions present in ITER, a test campaign was performed in 2012–2013 to verify the adequacy of the main components of the IVVS probe. The IVVS components inspected were an optical encoder, passive components and two customized ultrasonic piezoceramic motors that were instrumented with various sensors. A general architecture of the Data Acquisition and Control System (DACS) was defined and then specialized for each test. To be suitable for this test campaign, the DACS had to host various I/O modules and to properly interface the driver of the customized piezo motors, in order to permit the full control of the test and the acquisition of experimental data. This paper presents the instrumentation solutions designed and implemented for different facilities constraints and the related DACS developed in four specialized versions for the described test campaign.

  20. The Benefit of Self-Testing and Interleaving for Synthesizing Concepts across Multiple Physiology Texts

    Linderholm, Tracy; Dobson, John; Yarbrough, Mary Beth

    2016-01-01

    A testing-based learning strategy is one that relies on the act of recalling (i.e., testing) information after exposure, and interleaving is a strategy in which the learning materials are presented in a serial order (e.g., "texts 1, 2, 3, 1, 2, 3, 1, 2, 3") versus a blocked order (e.g., "texts 1, 1, 1, 2, 2, 2, 3, 3, 3").…