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Sample records for msn anp born

  1. ANP3 & NAP2

    DEFF Research Database (Denmark)

    Lindberg, Erik

    1996-01-01

    Modelling and SimulationANP3 introductionNAP2 introductionThe Exended Node EquationsThe input languages of ANP3 and NAP2The output from ANP3 and NAP2Literature......Modelling and SimulationANP3 introductionNAP2 introductionThe Exended Node EquationsThe input languages of ANP3 and NAP2The output from ANP3 and NAP2Literature...

  2. Copeptin and MR-proADM in umbilical cord plasma reflect perinatal stress in neonates born to mothers with diabetes and MR-proANP reflects maternal diabetes

    DEFF Research Database (Denmark)

    Smith, Julie; Halse, Karen G; Damm, Peter

    2013-01-01

    To examine concentrations of three cardiovascular propeptides in umbilical cord plasma of neonates born to mothers with Type 1, Type 2 and gestational diabetes. Measurement of cardiovascular markers in umbilical cord plasma may potentially help identify neonates at risk of postnatal complications...

  3. Integration of Framatome ANP

    International Nuclear Information System (INIS)

    Krebs, W.D.; Bouteille, F.

    2001-01-01

    The environment of nuclear power has changed greatly in the past few years. Cross-border exchanges of electricity have increased considerably, and more and more free and open markets add to the transparency of the cost situation in power generation. This is the environment in which a new firm is offering the necessary know-how to power companies and nuclear power plant operators. The two leading firms, Framatome and Siemens, have merged their nuclear divisions into Framatome ANP. The new company is active in all areas of nuclear power: New nuclear power plant construction, maintenance, nuclear fuel supply and nuclear power plant services in Europe, Asia, and America. More than ninety nuclear power plants, which is tantamount to 30% of the capacity installed worldwide, were built by the two companies, which makes Framatome ANP a leading enterprise for the long-term development of nuclear power. Framatome ANP merges a number of activities characterized by histories and corporate culture of their own within the framework of their respective political, economic, and social environments. The outcome is variety to be combined with extensive experience. Cooperation on the basis of a combination of best experience, the exchange of know-how, and the acceptance of differences offers the best opportunities for future developments which, however, also require the best possible preparation. This is underscored by the experience that some 75% of all company mergers fail to achieve the desired goals of synergy and cost savings. (orig.) [de

  4. Atrial natriuretic peptide (ANP)-granules: ultrastructure ...

    African Journals Online (AJOL)

    ANP) are present in the four regions of the atrial-auricular complex (two atria and two auricles). ANP-immunoreactivity was detected in all granules from the four regions. Ultrastructurally, atrial myocytes show the presence of very electron dense ...

  5. Regulation of atrial natriuretic peptide (ANP) secretion

    International Nuclear Information System (INIS)

    Ruskoaho, H.; Toth, M.; Lang, R.E.; Unger, Th.; Garten, D.

    1986-01-01

    To investigate the role of calcium, protein kinase C and adenylate cyclase in the ANP secretion, the secretory responses from isolated perfused rat hearts to a calcium channel activator, Bay k8644 (methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluomethylphenyl)-2-pyridine-5-carboxylate), the calcium ionophore (A23187), the phorbol ester (12-0-tetradecanoylphorbol-13-acetate, TPA), and to forskolin were studied. ANP in perfusate was measured by radioimmunoassay 10 min before and during the infusion (30 min) of various agents at 2 min intervals. A23187 (5.7 x 10 -7 ) induced a sharp increase, whereas TPA (0.15 - 1.6 x 10 -7 ) caused a slowly progressive increase in ANP secretion. 4a-phorbol-12,13-didecanoate, a non-active phorbol ester, had no effect on ANP secretion. Bay k8644 (4 x 10 -7 ) and forskolin (1 x 10 -6 ) alone caused small but sustained increase in ANP secretion. The combination of TPA with Bay k8644, forskolin or A23187 stimulated ANP secretion higher than the calculated additive value for each agent. Dibuturyl-cAMP (1.6 x 10 -4 ) pretreatment also enhanced TPA-induced ANP release. 8-Bromo-cGMP (1.3 x 10 -4 ) and sodium nitroprusside (9 x 10 -5 ) alone had no effect, but both attenuated the TPA-induced ANP secretion. The results suggest that atrial cardiocytes possess at least two different secretory pathways for ANP secretion, which are probably dependent on protein kinase C and cyclic AMP

  6. Atrial natriuretic peptide (ANP)-granules: ultrastructure ...

    African Journals Online (AJOL)

    AJB SERVER

    2006-12-29

    Dec 29, 2006 ... morphometry and function. Eliane Florencio ... granules is greatest in the right atrium followed by the left atrium and left auricle and right auricle, in this order. ... family: Atrial natriuretic peptide (ANP), Urodilatin, Brain natriuretic ...

  7. Mobile MSN Messenger: Still a Complement?

    Directory of Open Access Journals (Sweden)

    Marcus Nyberg

    2008-10-01

    Full Text Available In order to understand how mobile instant messaging services can fit into the users’ current communication behavior, Ericsson Research performed a qualitative user study in Sweden in May 2007. The results showed that the respondents were positive towards (free of charge mobile MSN Messenger and perceived it as an ex¬tension of the computer-based version that could be used anywhere. However, although MSN Messenger on the com¬puter definitely was considered as a ‘must-have’ application, the mobile version was only perceived as a ‘nice-to-have’ application and a complement to text mes¬saging (SMS. Almost one year later, in April 2008, Ericsson Research performed a short qualita¬tive follow-up study with the same set of respondents to un¬derstand if and how the mobile MSN Messenger usage had changed. The results actually revealed that none of the re¬spondents used mobile MSN Messenger anymore as the application no longer was free of charge. On a general level, the study highlights important considera¬tions when intro¬ducing computer-based concepts and Internet services in a mo¬bile environment.

  8. Worldwide supply of Framatome ANP Fuel

    International Nuclear Information System (INIS)

    Jouan, J.

    2002-01-01

    Framatome-ANP is organized according to a matrix structure with 4 business groups and 3 regional divisions. The fuel business group with a workforce of about 4600 people is active in all the trades needed to design and manufacture nuclear fuel. The activity ranges from the production of zirconium alloys to the production of finished fuel assemblies, facilities are located in France, Germany and Usa. Framatome-ANP is the foremost vendor of LWR fuel worldwide with 41 % of the PWR market share and 22 % of the BWR market share. The global operating experience built up is based on more than 150.000 fuel assemblies delivered to 169 reactors in 18 countries. This long history has allowed Framatome-ANP to develop an efficient quality-improvement program based on experience feedback, for instance fuel rod failures induced by debris have been almost completely eliminated with the introduction of anti-debris devices equipping bottom nozzles. Framatome-ANP has developed a large range of engineering services, for instance core design teams can provide the most cost-effective fuel management schemes for cycle lengths from 6 to 24 months. The first technology transfer between China entities and Framatome related to the AFA-2G technology started in 1991 and was completed successfully in 1994. Since this date the Chinese manufacturer has supplied fuel reload for the units of Daya-Bay. (A.C.)

  9. ANP applied to electronics engineering project selection

    International Nuclear Information System (INIS)

    Habib, M.

    2010-01-01

    Project selection in Electronics engineering is a complex decision-making process. This research paper illustrates an application of ANP/AHP process. The AHP (Analytic Hierarchy Process) is employed to break down large unstructured decision problems into manageable and measureable components. The ANP, as the general form of AHP, is powerful to deal with complex decisions where interdependence exists in a decision model. The research paper discusses the use of the ANP, a general form of Saaty's analytic Network process, as a model to evaluate the value of competing Electronics projects. The research paper concludes with a case study describing the implementation of this model at an engineering college, including data based on the actual use of the decision making model. The case study helps to verify that AHP is an effective and efficient decision-making tool. A major contribution of this work is to provide a methodology for assessing the best project. Despite a number of publications applying AHP in project selection, this is probably the first time that an attempt has been made to apply AHP in an electronics project selection in an engineering university environment. (author)

  10. no Brasil: o protagonismo da ANPEd

    Directory of Open Access Journals (Sweden)

    Sandra Zákia Sousa

    2007-01-01

    Full Text Available Resultante del debate ocurrido, en mayo del 2007, entre socios de la ANPEd con actuación destacada en la creación, organización, gestión y en los rumbos de la asociación, el artículo presenta, a partir de una retrospectiva histórica, algunas visiones a respecto del movimiento de postgrado y de la pesquisa en educación en Brasil. El énfasis recae en los encaminamientos asumidos por la ANPEd, a partir de aspectos relacionados a su organización interna, bien como a su articulación con los órganos gubernamentales, grupos de la sociedad civil y otras asociaciones académicas y científicas. Además de los rescates, el análisis presenta perspectivas para la consolidación y ampliación de iniciativas de la ANPEd, en el sentido de fortalecer su actuación como inductora de la mejoría de la calidad de la pesquisa y de la formación del postgrado. En especial, destaca el protagonismo de la asociación, como interlocutora en la formulación e implementación de políticas públicas de educación.

  11. The organization of digital conversation on MSN

    Directory of Open Access Journals (Sweden)

    Artarxerxes Tiago Tácito Modesto

    2012-02-01

    Full Text Available The emergence of the Internet has caused a revolution with regard to new forms of interaction between people, offering experiences of real-time communication in so-called virtual environments. Given this scenario, new textual genres emerge, making room for innumerous possibilities of analysis under various approaches. In this paper, we aim at analyzing digital conversations, trying to verify, at first, the extent to which they approach or move away from face-to-face conversations. We also seek to identify, describe and analyze some interactional strategies inherent in this new genre. We base our analyzes on Conversation Analysis theory and Interactional Sociolinguistics to define conversational strategies of the “spoken written text” on the Internet. The corpus used in this work consists of digital conversations coming from the MSN instant messaging software from Microsoft Corporation, chosen because of its wide use among people who use the internet for communication.

  12. A contrast between DEMATEL-ANP and ANP methods for six sigma project selection: a case study in healthcare industry.

    Science.gov (United States)

    Ortíz, Miguel A; Felizzola, Heriberto A; Nieto Isaza, Santiago

    2015-01-01

    The project selection process is a crucial step for healthcare organizations at the moment of implementing six sigma programs in both administrative and caring processes. However, six-sigma project selection is often defined as a decision making process with interaction and feedback between criteria; so that it is necessary to explore different methods to help healthcare companies to determine the Six-sigma projects that provide the maximum benefits. This paper describes the application of both ANP (Analytic Network process) and DEMATEL (Decision Making trial and evaluation laboratory)-ANP in a public medical centre to establish the most suitable six sigma project and finally, these methods were compared to evaluate their performance in the decision making process. ANP and DEMATEL-ANP were used to evaluate 6 six sigma project alternatives under an evaluation model composed by 3 strategies, 4 criteria and 15 sub-criteria. Judgement matrixes were completed by the six sigma team whose participants worked in different departments of the medical centre. The improving of care opportunity in obstetric outpatients was elected as the most suitable six sigma project with a score of 0,117 as contribution to the organization goals. DEMATEL-ANP performed better at decision making process since it reduced the error probability due to interactions and feedback. ANP and DEMATEL-ANP effectively supported six sigma project selection processes, helping to create a complete framework that guarantees the prioritization of projects that provide maximum benefits to healthcare organizations. As DEMATEL- ANP performed better, it should be used by practitioners involved in decisions related to the implementation of six sigma programs in healthcare sector accompanied by the adequate identification of the evaluation criteria that support the decision making model. Thus, this comparative study contributes to choosing more effective approaches in this field. Suggestions of further work are also

  13. Using MSN Money to Perform Financial Ratio Analysis

    Science.gov (United States)

    Hsu, H. Christine

    2010-01-01

    In today's information technology world, real time financial data is readily available via many financial websites, such as MSN Money, Google Finance, Yahoo Finance, etc. The incorporation of computer technology in finance classes has become more popular than ever in this information technology rich environment. Mediated classrooms have rapidly…

  14. ANTARES: The HTR/VHTR project at Framatome ANP

    International Nuclear Information System (INIS)

    Gauthier, Jean-Claude; Brinkmann, Gerd; Copsey, Bernie; Lecomte, Michel

    2006-01-01

    Framatome ANP is developing a very high temperature reactor (VHTR), relying on its previous experience with high temperature reactor concepts, from its participation in the MODUL and the GT-MHR designs. While being a major actor in the nuclear reactor business with proven light water technology, AREVA wishes to be ready to meet the new challenges calling for small grid requirements, high temperature process heat and cogeneration. The Framatome ANP VHTR design for electricity production is based on an indirect cycle coupled to an 'off-the-shelf' combined cycle gas turbine. Although direct cycle HTRs are being promoted for their high efficiency, preliminary evaluations show that the Framatome ANP design efficiency is on par with a direct cycle while avoiding power generation system (PGS) developments and keeping the PGS contamination free. Moreover, the nuclear heat source of the indirect cycle could also be used to meet the heat supplies from a standard design for multiple applications

  15. Comprehensive Evaluation of Large Infrastructure Project Plan with ANP

    Institute of Scientific and Technical Information of China (English)

    HAN Chuan-feng; CHEN Jian-ye

    2005-01-01

    Analytic Network Process(ANP) was used in comprehensive evaluation of large infrastructure project plan. A model including social economy, ecological environment, and resources was established with ANP method. The evaluation pattern of hierarchy structure and comprehensive evaluation method for quantity and quality of large infrastructure project were put forward, which provides an effective way to evaluate the large infrastructure project plan. Quantitative analysis indicated that the internal dependence relation of hierarchy structure has influence on ranking results of plan. It is suggested that considering the internal relation can helps managers make effective decisions.

  16. Msn2p/Msn4p act as a key transcriptional activator of yeast cytoplasmic thiol peroxidase II.

    Science.gov (United States)

    Hong, Seung-Keun; Cha, Mee-Kyung; Choi, Yong-Soo; Kim, Won-Cheol; Kim, Il-Han

    2002-04-05

    We observed that the transcription of Saccharomyces cerevisiae cytoplasmic thiol peroxidase type II (cTPx II) (YDR453C) is regulated in response to various stresses (e.g. oxidative stress, carbon starvation, and heat-shock). It has been suggested that both transcription-activating proteins, Yap1p and Skn7p, regulate the transcription of cTPx II upon exposure to oxidative stress. However, a dramatic loss of transcriptional response to various stresses in yeast mutant strains lacking both Msn2p and Msn4p suggests that the transcription factors act as a principal transcriptional activator. In addition to two Yap1p response elements (YREs), TTACTAA and TTAGTAA, the presence of two stress response elements (STREs) (CCCCT) in the upstream sequence of cTPx II also suggests that Msn2p/Msn4p could control stress-induced expression of cTPx II. Analysis of the transcriptional activity of site-directed mutagenesis of the putative STREs (STRE1 and STRE2) and YREs (TRE1 and YRE2) in terms of the activity of a lacZ reporter gene under control of the cTPx II promoter indicates that STRE2 acts as a principal binding element essential for transactivation of the cTPx II promoter. The transcriptional activity of the cTPx II promoter was exponentially increased after postdiauxic growth. The transcriptional activity of the cTPx II promoter is greatly increased by rapamycin. Deletion of Tor1, Tor2, Ras1, and Ras2 resulted in a considerable induction when compared with their parent strains, suggesting that the transcription of cTPx II is under negative control of the Ras/cAMP and target of rapamycin signaling pathways. Taken together, these results suggest that cTPx II is a target of Msn2p/Msn4p transcription factors under negative control of the Ras-protein kinase A and target of rapamycin signaling pathways. Furthermore, the accumulation of cTPx II upon exposure to oxidative stress and during the postdiauxic shift suggests an important antioxidant role in stationary phase yeast cells.

  17. Atrial natriuretic peptide (ANP) increases urinary albumin excretion (UAE) in intact and uninephrectomized (UNX) rats

    International Nuclear Information System (INIS)

    Valentin, J.P.; Ribstein, J.; Mimran, A.

    1990-01-01

    Previous experimental observations have suggested that ANP increases the transcapillary shift of water and albumin. The present studies were conducted in anesthetized euvolemic rats 6 weeks after UNX or sham operation. The effect of iv infusion of 103-126 hANP was assessed on GFR and ERPF ( 99 Tc.DTPA and 131 I-hippuran clearances), and UAE (nephelemetric method). ANP infusion was associated with no change in mean arterial pressure during the low dose (LD) and a 30 mm Hg decrease during the high dose (HD). ANP induced a dose-dependent and reversible increase in UNaV. Both proximal (as assessed by lithium excretion) and distal reabsorption of sodium were decreased by ANP. GFR was altered whereas ERPF decreased only during HD-AMP; filtration fraction (FF) dose-dependently increased in response to ANP. UAE increased dose-dependently and to a similar extent in both groups in response to ANP. The increase in UAE was readily reversible after discontinuation of ANP. There was a positive correlation between changes in UAE and changes in FF induced by ANP. These results indicate that ANP has a potent albuminuric effect. The simultaneous increase in UAE and FF, which could explain the effect of ANP on proximal tubular handling of sodium, may result from an ANP-induced rise in intraglomerular capillary pressure and/or an increase in glomerular permeability to albumin

  18. Challenge nuclear power: portrait of the Framatome ANP

    International Nuclear Information System (INIS)

    Gueldner, R.

    2004-01-01

    The energy industry, which needs to meet the global energy and in particular the power demand of a world population that is continuously increasing - at present there are over 6.2 billion living on this Earth -, has for a few years now been undergoing fundamental change: In the wake of liberalization the course has been set for global competition. The companies involved in the field of nuclear energy, both plant operators and suppliers, have also been impacted by this change. Besides internal programs to cut costs and enhance capabilities, corporate mergers at the national and international level are also playing a significant role. Companies will thus be able to tackle future challenges, with good prospects for nuclear energy as a cost-effective, environmentally friendly form of power generation. In response to market trends the nuclear business activities of Framatome and Siemens were merged in early 2001 to form Framatome ANP, which now is an AREVA ad Siemens company. Framatome ANP is dedicated to the development and turnkey construction of nuclear power plants and research reactors as well as comprehensive engineering, electrical and I and C systems, plant services, modernization, fuel supplies and heavy component manufacture for many reactor designs, including those supplied by other vendors. The company is headquartered in Paris with regional subsidiaries in Germany and the U.S. AREVA has a 66 percent stake and Siemens a 34 percent stake in Framatome ANP. The German regional subsidiary Framatome ANP GmbH has its head offices in Erlangen. Its subsidiaries are Advanced Nuclear Fuels GmbH (ANF), which focuses on fuel production, and intelligeNDT Systems and Services GmbH and Co. KG, which performs nondestructive testing in the field of nuclear engineering and other high-tech branches of industry. (orig.)

  19. O despontar da educação especial na ANPED Surfacing of special education in ANPED

    Directory of Open Access Journals (Sweden)

    Elcie F. Salzano Masini

    2011-08-01

    Full Text Available Esta comunicação focaliza o nascimento do Grupo de Trabalho (GT de Educação Especial na ANPEd. Constitui uma retomada histórica da proposta de um grupo de professores e pesquisadores, da área de Educação Especial, de diferentes universidades do Brasil, que discutiu a pertinência de constituir um GT de Educação Especial na ANPEd. Nesse sentido foi consolidado um calendário de encontros para discutir linhas de pesquisa e a legislação atinente à Educação Especial e encaminhado ofício à Diretoria da ANPEd requerendo, oficialmente, a abertura de um espaço para a Educação Especial nas Reuniões da ANPEd. Acompanhou o ofício a justificativa para tal solicitação, enfatizando que a inclusão da Educação Especial no âmbito do ensino superior, especificamente formação de professores em nível de graduação voltada para os vários aspectos de Educação Especial, fez surgir a necessidade de realização de pesquisas desenvolvidas e vinculadas a programas de pós-graduação em Educação. Em resposta à solicitação surgiu o Grupo de Estudos (GE na ANPEd, em 1989. O artigo descreve o funcionamento do GE, da programação, dos participantes e de uma pesquisa coletiva envolvendo seis Estados do Brasil, que propiciou a passagem do GE a GT. A Educação Especial foi incluída como GT na XV Reunião da ANPEd, em 1992. São apresentadas decisões tomadas pelos participantes do GT, nessa Reunião, referentes aos objetivos e funcionamento do GT. No encerramento da XV Reunião da ANPEd, a primeira coordenadora do GT de Educação Especial - uma professora da Faculdade de Educação da USP, que coordenou o GT de Educação Especial, de 1989 a 1992 - passou a coordenação para uma professora da Faculdade de Educação da UERJ.This paper focuses on the creation of the Work Group (WG of Special Education in ANPEd (National Association of Post-Graduation and Research. It is a historical review of a proposal made by a group of professors

  20. Influence of glutamine on the effect of resistance exercise on cardiac ANP in rats

    Directory of Open Access Journals (Sweden)

    Romeu Rodrigues de Souza

    2015-03-01

    Full Text Available Various nutritional supplements (herbs, vitamins, and micronutrients improve responses and adaptations to resistance exercise. ANP is a heart hormone that contributes to fluid, electrolyte and blood pressure homeostasis through its natriuretic and vasodilative actions. In the present study, the adaptation of ANP in response to resistance exercise was investigated in rats supplemented with glutamine for five weeks. The results showed that supplementation with glutamine did not influence the number of ANP granules per atrial cardiocyte in sedentary animals. In exercised-trained rats, the number and diameter of the granules was significantly higher in comparison with the control group and in exercised animals supplemented with glutamine there was significant increase in the number and diameter of ANP granules compared with controls. Altogether, these data indicated that in resistance exercise rats, glutamine significantly enhances cardiac ANP thus implicating the beneficial effects of glutamine supplementation to the ANP system.

  1. MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.

    Directory of Open Access Journals (Sweden)

    Oliver Medvedik

    2007-10-01

    Full Text Available Calorie restriction (CR robustly extends the lifespan of numerous species. In the yeast Saccharomyces cerevisiae, CR has been proposed to extend lifespan by boosting the activity of sirtuin deacetylases, thereby suppressing the formation of toxic repetitive ribosomal DNA (rDNA circles. An alternative theory is that CR works by suppressing the TOR (target of rapamycin signaling pathway, which extends lifespan via mechanisms that are unknown but thought to be independent of sirtuins. Here we show that TOR inhibition extends lifespan by the same mechanism as CR: by increasing Sir2p activity and stabilizing the rDNA locus. Further, we show that rDNA stabilization and lifespan extension by both CR and TOR signaling is due to the relocalization of the transcription factors Msn2p and Msn4p from the cytoplasm to the nucleus, where they increase expression of the nicotinamidase gene PNC1. These findings suggest that TOR and sirtuins may be part of the same longevity pathway in higher organisms, and that they may promote genomic stability during aging.

  2. ANP (Atrial Natriuretic Peptide presence in the heart of a tunicate, Ciona intestinalis.

    Directory of Open Access Journals (Sweden)

    Aldo Gerbino

    2010-06-01

    Full Text Available Atrial natriuretic peptide was found in the heart of vertebrates, we studied the ANP presence in the heart of Ciona intestinalis. This is animal is very important because of the its evolutionary position between invertebrates and vertebrates. ANP presence was only revealed in myoepithelial cells of the myocardium. Results suggest the hypothesis that ANP is present not only in the vertebrates but also in the invertebrates and in Ciona heart ANP might play a similar role like in the heart of vertebrates.

  3. MODEL ANALYTICAL NETWORK PROCESS (ANP DALAM PENGEMBANGAN PARIWISATA DI JEMBER

    Directory of Open Access Journals (Sweden)

    Sukidin Sukidin

    2015-04-01

    Full Text Available Abstrak    : Model Analytical Network Process (ANP dalam Pengembangan Pariwisata di Jember. Penelitian ini mengkaji kebijakan pengembangan pariwisata di Jember, terutama kebijakan pengembangan agrowisata perkebunan kopi dengan menggunakan Jember Fashion Carnival (JFC sebagai event marketing. Metode yang digunakan adalah soft system methodology dengan menggunakan metode analitis jaringan (Analytical Network Process. Penelitian ini menemukan bahwa pengembangan pariwisata di Jember masih dilakukan dengan menggunakan pendekatan konvensional, belum terkoordinasi dengan baik, dan lebih mengandalkan satu even (atraksi pariwisata, yakni JFC, sebagai lokomotif daya tarik pariwisata Jember. Model pengembangan konvensional ini perlu dirancang kembali untuk memperoleh pariwisata Jember yang berkesinambungan. Kata kunci: pergeseran paradigma, industry pariwisata, even pariwisata, agrowisata Abstract: Analytical Network Process (ANP Model in the Tourism Development in Jember. The purpose of this study is to conduct a review of the policy of tourism development in Jember, especially development policies for coffee plantation agro-tourism by using Jember Fashion Carnival (JFC as event marketing. The research method used is soft system methodology using Analytical Network Process. The result shows that the tourism development in Jember is done using a conventional approach, lack of coordination, and merely focus on a single event tourism, i.e. the JFC, as locomotive tourism attraction in Jember. This conventional development model needs to be redesigned to reach Jember sustainable tourism development. Keywords: paradigm shift, tourism industry, agro-tourism

  4. Effects of nitrendipine on sodium balance during changes in sodium intake and low-dosage ANP

    NARCIS (Netherlands)

    Bijlsma, J. A.; Koomans, H. A.; Dorhout Mees, E. J.

    1991-01-01

    We found previously that calcium entry blockade with nitrendipine enhanced the natriuretic effect of high-dose atrial natriuretic peptide (ANP). It is unknown whether nitrendipine also influences the effect of physiological changes in ANP. We therefore studied the effect of nitrendipine on

  5. Processing-independent proANP measurement for low concentrations in plasma

    DEFF Research Database (Denmark)

    Mark, Peter D; Hunter, Ingrid; Terzic, Dijana

    2018-01-01

    BACKGROUND: Decreased concentrations of pro-atrial-derived natriuretic peptides (proABP) in plasma have been associated with obesity and suggested as a predictor of type 2 diabetes. However, assays for measuring proANP are generally aimed to quantitate higher concentrations of proANP associated...

  6. Framatome ANP worldwide experience in ageing and plant life management

    International Nuclear Information System (INIS)

    Daeuwel, W.; Kastner, B.; Nopper, H.

    2004-01-01

    The deregulation of the power generation industry has resulted in increased competitive pressure and is forcing operators to improve plant operating economy while maintaining high levels of plant safety. A key factor to meet this challenge is to apply a comprehensive plant life management (PLIM) approach which addresses all relevant ageing and degradation mechanisms regarding the safety concept, plant components and documentation, plant personnel, consumables, operations management system and administrative controls. For this reason, Framatome ANP has developed an integrated PLIM concept focussing on the safety concept, plant components and documentation. Representative examples for plant wide analyses are described in the following. The results of the analyses support the plant owner for taking the strategic decisions, involved in plant life extension (PLEX). (orig.)

  7. Web conferencing systems: Skype and MSN in telepathology.

    Science.gov (United States)

    Klock, Clóvis; Gomes, Regina de Paula Xavier

    2008-07-15

    Virtual pathology is a very important tool that can be used in several ways, including interconsultations with specialists in many areas and for frozen sections. We considered in this work the use of Windows Live Messenger and Skype for image transmission. The conference was made through wide broad internet using Nikon E 200 microscope and Digital Samsung Colour SCC-131 camera. Internet speed for transmission varied from 400 Kb to 2.0 Mb. Both programs allow voice transmission concomitant to image, so the communication between the involved pathologists was possible using microphones and speakers. A live image could be seen by the receptor pathologist who was able to ask for moving the field or increase/diminish the augmentation. No phone call or typing required. The programs MSN and Skype can be used in many ways and with different operational systems installed in the computer. The capture system is simple and relatively cheap, what proves the viability of the system to be used in developing countries and in cities where do not exist pathologists. With the improvement of software and the improvement of digital image quality, associated to the use of the high speed broad band Internet this will be able to become a new modality in surgical pathology.

  8. X-linked primary immunodeficiency associated with hemizygous mutations in the moesin (MSN) gene.

    Science.gov (United States)

    Lagresle-Peyrou, Chantal; Luce, Sonia; Ouchani, Farid; Soheili, Tayebeh Shabi; Sadek, Hanem; Chouteau, Myriam; Durand, Amandine; Pic, Isabelle; Majewski, Jacek; Brouzes, Chantal; Lambert, Nathalie; Bohineust, Armelle; Verhoeyen, Els; Cosset, François-Loïc; Magerus-Chatinet, Aude; Rieux-Laucat, Frédéric; Gandemer, Virginie; Monnier, Delphine; Heijmans, Catherine; van Gijn, Marielle; Dalm, Virgil A; Mahlaoui, Nizar; Stephan, Jean-Louis; Picard, Capucine; Durandy, Anne; Kracker, Sven; Hivroz, Claire; Jabado, Nada; de Saint Basile, Geneviève; Fischer, Alain; Cavazzana, Marina; André-Schmutz, Isabelle

    2016-12-01

    We investigated 7 male patients (from 5 different families) presenting with profound lymphopenia, hypogammaglobulinemia, fluctuating monocytopenia and neutropenia, a poor immune response to vaccine antigens, and increased susceptibility to bacterial and varicella zoster virus infections. We sought to characterize the genetic defect involved in a new form of X-linked immunodeficiency. We performed genetic analyses and an exhaustive phenotypic and functional characterization of the lymphocyte compartment. We observed hemizygous mutations in the moesin (MSN) gene (located on the X chromosome and coding for MSN) in all 7 patients. Six of the latter had the same missense mutation, which led to an amino acid substitution (R171W) in the MSN four-point-one, ezrin, radixin, moesin domain. The seventh patient had a nonsense mutation leading to a premature stop codon mutation (R533X). The naive T-cell counts were particularly low for age, and most CD8 + T cells expressed the senescence marker CD57. This phenotype was associated with impaired T-cell proliferation, which was rescued by expression of wild-type MSN. MSN-deficient T cells also displayed poor chemokine receptor expression, increased adhesion molecule expression, and altered migration and adhesion capacities. Our observations establish a causal link between an ezrin-radixin-moesin protein mutation and a primary immunodeficiency that could be referred to as X-linked moesin-associated immunodeficiency. Copyright © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  9. ANP32B is a nuclear target of henipavirus M proteins.

    Directory of Open Access Journals (Sweden)

    Anja Bauer

    Full Text Available Membrane envelopment and budding of negative strand RNA viruses (NSVs is mainly driven by viral matrix proteins (M. In addition, several M proteins are also known to be involved in host cell manipulation. Knowledge about the cellular targets and detailed molecular mechanisms, however, is poor for many M proteins. For instance, Nipah Virus (NiV M protein trafficking through the nucleus is essential for virus release, but nuclear targets of NiV M remain unknown. To identify cellular interactors of henipavirus M proteins, tagged Hendra Virus (HeV M proteins were expressed and M-containing protein complexes were isolated and analysed. Presence of acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B in the complex suggested that this protein represents a direct or indirect interactor of the viral matrix protein. Over-expression of ANP32B led to specific nuclear accumulation of HeV M, providing a functional link between ANP32B and M protein. ANP32B-dependent nuclear accumulation was observed after plasmid-driven expression of HeV and NiV matrix proteins and also in NiV infected cells. The latter indicated that an interaction of henipavirus M protein with ANP32B also occurs in the context of virus replication. From these data we conclude that ANP32B is a nuclear target of henipavirus M that may contribute to virus replication. Potential effects of ANP32B on HeV nuclear shuttling and host cell manipulation by HeV M affecting ANP32B functions in host cell survival and gene expression regulation are discussed.

  10. Angiotensin-(1-7) attenuates hyposmolarity-induced ANP secretion via the Na+-K+ pump.

    Science.gov (United States)

    Shah, Amin; Oh, Young-Bin; Shan, Gao; Song, Chang Ho; Park, Byung-Hyun; Kim, Suhn Hee

    2010-09-01

    The alteration in osmolarity challenges cell volume regulation, a vital element for cell survival. Hyposmolarity causes an increase in cell volume. Recently, it has been reported that the renin-angiotensin system (RAS) plays a role in cell volume regulation. We investigated the effect of angiotensin-(1-7) [Ang-(1-7)] on hyposmolarity-induced atrial natriuretic peptide (ANP) secretion in normal and diabetic (DM) rat atria and modulation of the effect of Ang-(1-7) by the Na(+)-K(+) pump. Using isolated control rat atria, we observed that perfusion of hyposmotic solution into the atria increased ANP secretion. When Ang-(1-7) [0.1 microM or 1 microM] was perfused in a hyposmolar solution, it decreased the hyposmolarity-induced ANP secretion in a dose-dependent manner. This effect of Ang-(1-7) could be mediated by the Na(+)-K(+) pump, since ouabain, an Na(+)-K(+) pump inhibitor, significantly decreased the effect of Ang-(1-7) on hyposmolarity-induced ANP secretion. In contrast, N(omega) Nitro-l-arginine methyl ester hydrochloride (l-NAME) did not modify the effect of Ang-(1-7) on the hyposmolarity-induced ANP secretion. Interestingly, the ANP secretion was increased robustly by the perfusion of the hyposmolar solution in the DM atria, as compared to the control atria. However, the inhibitory effect of Ang-(1-7) on the hyposmolarity-induced ANP secretion was not observed in the DM atria. In the DM atria, atrial contractility was significantly increased. Taken together, we concluded that Ang-(1-7) attenuated hyposmolarity-induced ANP secretion via the Na(+)-K(+) pump and a lack of Ang-(1-7) response in DM atria may partly relate to change in Na(+)-K(+) pump activity. Copyright 2010 Elsevier Inc. All rights reserved.

  11. Induction of neutral trehalase Nth1 by heat and osmotic stress is controlled by STRE elements and Msn2/Msn4 transcription factors: variations of PKA effect during stress and growth.

    Science.gov (United States)

    Zähringer, H; Thevelein, J M; Nwaka, S

    2000-01-01

    Saccharomyces cerevisiae neutral trehalase, encoded by NTH1, controls trehalose hydrolysis in response to multiple stress conditions, including nutrient limitation. The presence of three stress responsive elements (STREs, CCCCT) in the NTH1 promoter suggested that the transcriptional activator proteins Msn2 and Msn4, as well as the cAMP-dependent protein kinase (PKA), control the stress-induced expression of Nth1. Here, we give direct evidence that Msn2/Msn4 and the STREs control the heat-, osmotic stress- and diauxic shift-dependent induction of Nth1. Disruption of MSN2 and MSN4 abolishes or significantly reduces the heat- and NaCl-induced increases in Nth1 activity and transcription. Stress-induced increases in activity of a lacZ reporter gene put under control of the NTH1 promoter is nearly absent in the double mutant. In all instances, basal expression is also reduced by about 50%. The trehalose concentration in the msn2 msn4 double mutant increases less during heat stress and drops more slowly during recovery than in wild-type cells. This shows that Msn2/Msn4-controlled expression of enzymes of trehalose synthesis and hydrolysis help to maintain trehalose concentration during stress. However, the Msn2/Msn4-independent mechanism exists for heat control of trehalose metabolism. Site-directed mutagenesis of the three STREs (CCCCT changed to CATCT) in NTH1 promoter fused to a reporter gene indicates that the relative proximity of STREs to each other is important for the function of NTH1. Elimination of the three STREs abolishes the stress-induced responses and reduces basal expression by 30%. Contrary to most STRE-regulated genes, the PKA effect on the induction of NTH1 by heat and sodium chloride is variable. During diauxic growth, NTH1 promoter-controlled reporter activity strongly increases, as opposed to the previously observed decrease in Nth1 activity, suggesting a tight but opposite control of the enzyme at the transcriptional and post-translational levels

  12. A subset of FG-nucleoporins is necessary for efficient Msn5-mediated nuclear protein export

    Science.gov (United States)

    Finn, Erin M.; DeRoo, Elise P.; Clement, George W.; Rao, Sheila; Kruse, Sarah E.; Kokanovich, Kate M.; Belanger, Kenneth D.

    2013-01-01

    The transport of proteins between the cytoplasm and nucleus requires interactions between soluble transport receptors (karyopherins) and phenylalanine-glycine (FG) repeat domains on nuclear pore complex proteins (nucleoporins). However, the role of specific FG repeat-containing nucleoporins in nuclear protein export has not been carefully investigated. We have developed a novel kinetic assay to investigate the relative export kinetics mediated by the karyopherin Msn5/Kap142 in yeast containing specific FG-Nup mutations. Using the Msn5 substrate Crz1 as a marker for Msn5-mediated protein export, we observe that deletions of NUP100 or NUP2 result in decreased rates of Crz1 export, while nup60Δ and nup42Δ mutants do not vary significantly from wild type. The decreased Msn5 export rate in nup100Δ was confirmed using Mig1-GFP as a transport substrate. A nup100ΔGLFG mutant shows defects in nuclear export kinetics similar to a nup100Δ deletion. Removal of FG-repeats from Nsp1 also decreases export kinetics, while a loss of Nup1 FXFGs does not. To confirm that our export data reflected functional differences in protein localization, we performed Crz1 transcription activation assays using a CDRE::LacZ reporter gene that is upregulated upon increased transcription activation by Crz1 in vivo. We observe that expression from this reporter increases in nup100ΔGLFG and nsp1ΔFGΔFXFG strains that exhibit decreased Crz1 export kinetics but resembles wild-type levels in nup1ΔFXFG strains that do not exhibit export defects. These data provide evidence that the export of Msn5 is likely mediated by a specific subset of FG-Nups and that the GLFG repeat domain of Nup100 is important for Msn5-mediated nuclear protein export. PMID:23295456

  13. Relationship between the actions of atrial natriuretic peptide (ANP, guanylin and uroguanylin on the isolated kidney

    Directory of Open Access Journals (Sweden)

    M.S. Santos-Neto

    1999-08-01

    Full Text Available Guanylin and uroguanylin are peptides that bind to and activate guanylate cyclase C and control salt and water transport in many epithelia in vertebrates, mimicking the action of several heat-stable bacteria enterotoxins. In the kidney, both of them have well-documented natriuretic and kaliuretic effects. Since atrial natriuretic peptide (ANP also has a natriuretic effect mediated by cGMP, experiments were designed in the isolated perfused rat kidney to identify possible synergisms between ANP, guanylin and uroguanylin. Inulin was added to the perfusate and glomerular filtration rate (GFR was determined at 10-min intervals. Sodium was also determined. Electrolyte dynamics were measured by the clearance formula. Guanylin (0.5 µg/ml, N = 12 or uroguanylin (0.5 µg/ml, N = 9 was added to the system after 30 min of perfusion with ANP (0.1 ng/ml. The data were compared at 30-min intervals to a control (N = 12 perfused with modified Krebs-Hanseleit solution and to experiments using guanylin and uroguanylin at the same dose (0.5 µg/ml. After previous introduction of ANP in the system, guanylin promoted a reduction in fractional sodium transport (%TNa+, P<0.05 (from 78.46 ± 0.86 to 64.62 ± 1.92, 120 min. In contrast, ANP blocked uroguanylin-induced increase in urine flow (from 0.21 ± 0.01 to 0.15 ± 0.007 ml g-1 min-1, 120 min, P<0.05 and the reduction in fractional sodium transport (from 72.04 ± 0.86 to 85.19 ± 1.48, %TNa+, at 120 min of perfusion, P<0.05. Thus, the synergism between ANP + guanylin and the antagonism between ANP + uroguanylin indicate the existence of different subtypes of receptors mediating the renal actions of guanylins.

  14. Hepatocyte cytoskeleton during ischemia and reperfusion influence of ANP-mediated p38 MAPK activation

    Institute of Scientific and Technical Information of China (English)

    Melanie Keller; Alexander L Gerbes; Stefanie Kulhanek-Heinze; Tobias Gerwig; Uwe Grützner; Nico van Rooijen; Angelika M Vollmar; Alexandra K Kiemer

    2005-01-01

    AIM: To determine functional consequences of this activation, whereby we focused on a potential regulation of the hepatocyte cytoskeleton during ischemia and reperfusion.METHODS: For in vivo experiments, animals received ANP (5 μg/kg) intravenously. In a different experimental setting, isolated rat livers were perfused with KH-buffer ±ANP (200 nmol/L)±SB203580 (2 μmol/L). Liverswere then kept under ischemic conditions for 24 h, and either transplanted or reperfused. Actin, Hsp27, and phosphorylated Hsp27 were determined by Western blotting, p38 MAPK activity by in vitro phosphorylation assay. F-actin distribution was determined by confocal microscopy.RESULTS: We first confirmed that ANP preconditioning leads to an activation of p38 MAPK and observedalterations of the cytoskeleton in hepatocytes of ANPpreconditioned organs. ANP induced an increase of hepatic F-actin after ischemia, which could be prevented by the p38 MAPK inhibitor SB203580 but had no effect on bile flow. After ischemia untreated livers showed a translocation of Hsp27 towards the cytoskeleton and an increase in total Hsp27, whereas ANP preconditioning prohibited translocation but caused an augmentation of Hsp27 phosphorylation. This effect is also mediated via p38 MAPK, since it was abrogated by the p38 MAPK inhibitor SB203580.CONCLUSION: This study reveals that ANP-mediated p38 MAPK activation leads to changes in hepatocyte cytoskeleton involving an elevation of phosphorylated Hsp27 and thereby for the first time shows functional consequences of ANP-induced hepatic p38 MAPK activation.

  15. Effects of propranolol and pindolol on plasma ANP levels in humans at rest and during exercise.

    Science.gov (United States)

    Bouissou, P; Galen, F X; Richalet, J P; Lartigue, M; Devaux, F; Dubray, C; Atlan, G

    1989-08-01

    In attempt to elucidate whether the beta-adrenoceptor is involved in the control of atrial natriuretic peptide (ANP) secretion, plasma immunoreactive ANP level was measured at rest, in recumbent and upright positions, and during graded maximal ergocycle exercise in nine healthy male subjects (23 +/- 0.5 years of age) treated for 3 days with nonselective beta-blockers propranolol (150 mg/day) or pindolol (15 mg/day) or with placebo. The effects of beta-blockers, which differ by their hemodynamic actions at rest because of the intrinsic sympathomimetic activity of pindolol, were compared. Maximal O2 consumption (VO2max) during beta-blockade was not significantly different from the placebo value. Resting heart rate was not affected by pindolol treatment but was decreased with propranolol (-10 beats/min). Both beta-blockers caused a reduction in heart rate at all the exercise intensities. Mean blood pressure was not affected by beta-blockade at rest but was significantly reduced during exercise. During placebo treatment, plasma ANP increased in response to exercise intensities greater than 65% of VO2max. At 100% VO2max plasma ANP was nearly doubled (101.5 +/- 14 pg/ml) compared with the basal value in upright position (56.6 +/- 15 pg/ml). beta-Blockade caused a marked elevation in plasma ANP at all the levels of activity. Despite different hemodynamic responses to pindolol and propranolol, both beta-blockers produced similar increases in the basal level of plasma ANP. These rises were maintained in the course of exercise tests, and no significant difference was found between propranolol and pindolol. We conclude that beta-adrenoceptor mechanisms are not directly responsible for tonic and exercise-induced ANP secretion in humans.(ABSTRACT TRUNCATED AT 250 WORDS)

  16. Atrial Natriuretic Peptide (ANP) in early pregnancy is associated with development of preeclampsia in type 1 diabetes

    DEFF Research Database (Denmark)

    Nielsen, Lene Ringholm; Pedersen-Bjergaard, Ulrik; Thorsteinsson, Birger

    2011-01-01

    The vasoactive markers of cardiac overload Atrial Natriuretic Peptide (ANP) and Brain Natriuretic Peptide (BNP) are elevated in preeclampsia. This study documents higher ANP concentrations as early as at 9 weeks in type 1 diabetic women subsequently developing preeclampsia suggesting that preecla......The vasoactive markers of cardiac overload Atrial Natriuretic Peptide (ANP) and Brain Natriuretic Peptide (BNP) are elevated in preeclampsia. This study documents higher ANP concentrations as early as at 9 weeks in type 1 diabetic women subsequently developing preeclampsia suggesting...... that preeclampsia is associated with cardiovascular changes in early pregnancy....

  17. Audience and Witnessing: Research into Dramatherapy using Vignettes and aMSN Messenger

    Science.gov (United States)

    Jones, Phil

    2008-01-01

    This article describes the process of research undertaken to examine therapists' responses to the concept of the core processes of change in dramatherapy. The research uses a combination of vignette description and analysis using aMSN messenger. The article describes the theoretical underpinning and rationale to the approach, and the…

  18. An ANP-based network to measure the impact of Lean production on organisational performance

    Directory of Open Access Journals (Sweden)

    José Luis Ruano Pérez

    2018-04-01

    Full Text Available Purpose: The main objective of this research is to design a decision-making network, based on the Analytic Network Process (ANP technique (Saaty, 1996, which will include the main elements to take into account when stating the effect that the application of LP techniques has got on the performance of an organisation, measured this through a Performance Measurement System (PMS. Design/methodology/approach: The authors have carried out a scientific literature search to state what the main LP techniques are –and how to group them into different clusters- and have then applied the ANP, its first phase, in order to design the decisional network. Findings: There is a gap in the literature when trying to identify and quantify to what extent the implementation of LP techniques affects to organisational performance. The ANP is an appropriate technique to do so due to the need of gathering and quantifying experts’ opinions. Originality/value: The designed ANP-based network to measure the impact of LP over organisational performance is a novel approach. This paper justifies its usage and paves the way to implement the rest of the ANP phases in future research work.

  19. An ANP-based approach for the selection of photovoltaic solar power plant investment projects

    International Nuclear Information System (INIS)

    Aragones-Beltran, P.; Pastor-Ferrando, J.P.; Rodriguez-Pozo, F.; Chaparro-Gonzalez, F.

    2010-01-01

    In this paper the Analytic Network Process (ANP) is applied to the selection of photovoltaic (PV) solar power projects. These projects follow a long management and execution process from plant site selection to plant start-up. As a consequence, there are many risks of time delays and even of project stoppage. In the case study presented in this paper a top manager of an important Spanish company that operates in the power market has to decide on the best PV project (from four alternative projects) to invest based on risk minimization. The manager identified 50 project execution delay and/or stoppage risks. The influences between the elements of the network (groups of risks and alternatives) were identified and analyzed using the ANP multicriteria decision analysis method. Two different ANP models were used: one hierarchy model (that considers AHP as a particular case of ANP) and one network-based model. The results obtained in each model were compared and analyzed. The main conclusion is that unlike the other models used in the study, the single network model can manage all the information of the real-world problem and thus it is the decision analysis model recommended by the authors. The strengths and weaknesses of ANP as a multicriteria decision analysis tool are also described in the paper. (author)

  20. Total plasma proANP increases with atrial dilatation in horses

    DEFF Research Database (Denmark)

    Van Der Vekens, N; Hunter, I; Timm, A

    2015-01-01

    ANP product in plasma has proven to be successful in human medicine, but has never been used in horses. The aims were to establish an equine proANP reference interval by measurement of the total proANP product using PIA and to examine the proANP concentrations in horses with atrial dilatation. Sample...... stability was studied by comparison of storage at -80°C and -20°C. Plasma samples were obtained from 23 healthy horses, 12 horses with moderate or severe valvular regurgitation without atrial dilatation and 42 horses with valvular regurgitation and atrial dilatation. The proANP concentration...... was significantly (Phorses with atrial dilatation (761.4 (442.1-1859.1) pmol/l) than in healthy horses (491.6 (429.5-765.9) pmol/l; Phorses with cardiac disease but without atrial dilatation (544.4 (457.0-677.6) pmol/l). A cut-off value (573.8 pmol/l) for detection of atrial dilatation...

  1. APLIKASI ANALYTIC NETWORK PROCESS (ANP PADA PERANCANGAN SISTEM PENGUKURAN KINERJA (Studi Kasus pada PT. X

    Directory of Open Access Journals (Sweden)

    Iwan Vanany

    2003-01-01

    Full Text Available The paper discusses the application of Analytic Network Process (ANP to support the weighted of design performance measurement system with Balanced Scorecard method. During the time, the weighted uses method that disregarding interdependence between objectives strategy and Key Performance Indicator (KPI's. The method which often used in this weighted is Analytical Hierarchy Process (AHP. In fact this condition does not express the concept of strategy map of Balanced Scorecard. Therefore is needed apply the other weighted method which attention to the interdependence between Key Performance Indicator (KPI. Application of the weighted with ANP method is conducted at one of the power company. This company represents result of restructuring of PT. PLN (Persero. The result of design performance measurement system of PT. X are objective strategy, Key Performance Indicator (KPI and strategy map, will be weighted by method of ANP. Further more Modeling of ANP based on strategy map. The result of application indicates that related of model of strategy map in Balanced Scorecard at PT. X is Feedback Network (hiernet with phenomenon of inner and dependence of outer dependence. The perspective on Balanced Scorecard is identically with cluster on ANP, while objective strategy and KPI are identically with sub-element and element. Result of weighted with ANP method shows the existence of culmination of weighted on financial perspective of Strategy Map at PT. X. Abstract in Bahasa Indonesia : Makalah ini membahas aplikasi Analytic Network Process (ANP untuk mendukung pembobotan pada perancangan sistem pengukuran kinerja dengan metode Balanced Scorecard. Selama ini, pembobotan yang ada menggunakan metode yang mengabaikan saling keterkaitan antar strategi objektif dengan Key Performance Indicator (KPI-KPI -nya. Metode yang sering digunakan didalam pembobotan ini adalah Analytical Hierarchy Process (AHP. Kondisi ini sebenarnya tidak mencerminkan konsep Strategy Map

  2. Combination of high-performance liquid chromatography and radioimmunoassay for the measurement of urodilatin and α-hANP in the urine of healthy males

    International Nuclear Information System (INIS)

    Solc, J.; Bauer, K.; Timnik, A.; Doehlemann, C.; Strom, T.M.; Weil, J.; Solcova, A.

    1991-01-01

    Urodilatin (ANP-(95-126)), a natriuretic peptide in urine, and α-hANP (ANP-(99-126)) are crossreactive in the radioimmunoassay of α-hANP (ANP-RIA). The authors therefore developed a method to separate physiological amounts of urodilatin and α-hANP in urine by high-performance liquid chromatography followed by ANP-RIA of the separated fractions. They studied urine samples of 10 healthy adult males with a plasma α-hANP level of 41 ± 21 pg/ml (mean ± SD) and a total urinary ANP-RIA reactivity of 40 ± 21 pg/ml. In all urine samples they found three peaks of ANP-RIA reactivity, the first one coeluting with synthetic urodilatin, the second one with the retention time of α-hANP and a late eluting ANP-RIA-reactive peak, possibly containing degradation products. The ratio of urodilatin/α-hANP was 0.77 ± 0.17

  3. Circulating atrial natriuretic peptide (ANP) and central blood volume (CBV) in cirrhosis

    DEFF Research Database (Denmark)

    Schütten, H J; Henriksen, Jens Henrik Sahl; Bendtsen, F

    1986-01-01

    Endogenous alpha-atrial natriuretic peptide (ANP) in plasma is elevated in various hypervolaemic conditions. Possible relationships between circulating immunoreactive ANP and cardiovascular and splanchnic haemodynamics were therefore studied in patients with cirrhosis (n = 16) and controls (n = 12...... or diuretic treatment. Central blood volume (CBV, i.e. the blood volume in the heart cavities, lungs, and aorta), determined from the mean transit time of 125I-labelled of 125I-labelled albumin and cardiac output, was significantly reduced in cirrhotics compared to controls (1.45 +/- 0.12 vs. 1.83 +/- 0.10 l...

  4. Measurement of the total proANP product in mammals by processing independent analysis

    DEFF Research Database (Denmark)

    Hunter, Ingrid; Rehfeld, Jens Frederik; Gøtze, Jens Peter

    2011-01-01

    (proANP) and its products irrespective of variable post-translational processing. The processing-independent assay (PIA) was developed raising mono-specific antibodies against the C-terminus of sequence 1-16 in proANP. The assay procedure included plasma extraction followed by tryptic cleavage, which...... releases the assay epitope from the N-terminal region. The PIA was tested in elderly patients with symptoms of heart failure (n=450), in pigs with acute myocardial infarction (n=21), and in normal dogs and dogs with heart failure (n=77). The epitope specificity permitted reliable measurement in man, dog...

  5. ANP, BNP and D-dimer predict right ventricular dysfunction in patients with acute pulmonary embolism

    DEFF Research Database (Denmark)

    Borgwardt, Henrik Gutte; Mortensen, Jann; Jensen, Claus V

    2010-01-01

    The aim of this study was to predict right ventricular dysfunction (RVD) using plasma concentration of D-dimer, pro-atrial natriuretic peptide (pro-ANP), brain natriuretic peptide (BNP), endothelin-1 (ET-1) and cardiac troponin I (TNI) in patients with pulmonary embolism (PE).......The aim of this study was to predict right ventricular dysfunction (RVD) using plasma concentration of D-dimer, pro-atrial natriuretic peptide (pro-ANP), brain natriuretic peptide (BNP), endothelin-1 (ET-1) and cardiac troponin I (TNI) in patients with pulmonary embolism (PE)....

  6. Comments on Resolution ANP 43/2007 and technical regulation of the system operational safety management - SGSO; Comentarios a Resolucao ANP 43/2007 e ao regulamento tecnico do sistema de gerenciamento da seguranca operacional - SGSO

    Energy Technology Data Exchange (ETDEWEB)

    Lima, Flavio Augusto Pimentel de [Petroleo Brasileiro S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil)

    2012-07-01

    Some of the provisions of ANP Board Resolution n. 43, in December, 6th, 2007 (R-ANP 43/2007) have to receive special attention by economic agents, in consideration of the excessive extent and fuzziness and also the absence of objective criteria to assess their fulfillment by the Concessionaire. This paper will comment the responsibility of the Concessionaire (as show in article 1st , 2nd paragraph, of R-ANP 43/2007); the ANP authority (as show in article 1st , 3rd paragraph, of R-ANP 43/2007); the delivery of Operational Security Documentation and the imposition of penalties for violations of the SGSO. In conclusion, this paper will indicated some aspects which, from a legal point of view, need to be improved to provide greater legal certainty for economic agents. (author)

  7. Atrial Natriuretic Peptide (ANP) in early pregnancy is associated with development of preeclampsia in type 1 diabetes

    DEFF Research Database (Denmark)

    Nielsen, Lene Ringholm; Pedersen-Bjergaard, Ulrik; Thorsteinsson, Birger

    2011-01-01

    The vasoactive markers of cardiac overload Atrial Natriuretic Peptide (ANP) and Brain Natriuretic Peptide (BNP) are elevated in preeclampsia. This study documents higher ANP concentrations as early as at 9 weeks in type 1 diabetic women subsequently developing preeclampsia suggesting...... that preeclampsia is associated with cardiovascular changes in early pregnancy....

  8. Globalization of the nuclear industry: Developing technology - Framatome ANP's experience

    International Nuclear Information System (INIS)

    Kaluzny, Y.; Dams, W.; Reynolds, R.

    2006-01-01

    Full text: In the last 15 years, Framatome ANP has moved from being a purely national player to being a global market leader. This is due to a series of successful mergers and acquisitions, including the acquisition of the nonmilitary nuclear activity of Babcock and Wilcox in the late 1980s and, more recently, the merger with Siemens-KWU's nuclear activities. Integration presented a number of challenges. There were undeniable cultural differences, reorganization was required to bring the business under control and a number of activities, such as finance, sales, R and D, marketing, engineering and manufacturing, and information systems had to be rationalized and integrated. The key factors that contributed to the success of this integration included a management team that was clearly committed to the success of the merger and the quick and clear definition of the strategy, vision and values of the new company, which had to be effectively communicated. A global organization which was not simply a group of three companies, each working in its own corner, was quickly established and multiregional task forces were appointed to identify possible synergies and propose how they could be put into practice. One of the key issues is R and D, which will be discussed as an example of what has been achieved. This activity is essential when preparing the future of the company as a whole, and one of the major challenges that had to be met was to find the best way of making use of all the skills available in it. A special multiregional, multi-activity organization has identified the existing skills and potential synergies in each of the technical areas and core businesses. A global R and D management process has been put in place under the strong leadership of the corporate R and D function. This process involves all the business units worldwide and has made it possible to set R and D objectives and identify the action to be taken in line with the group's strategic objectives

  9. MR-proANP improves prediction of mortality and cardiovascular events in patients with STEMI

    DEFF Research Database (Denmark)

    Lindberg, Søren; Jensen, Jan Skov; Pedersen, Sune H

    2015-01-01

    drawn immediately before PCI. Plasma MR-proANP was measured using an automated processing assay. Endpoints were all-cause mortality (n = 137) and the combined endpoint (n = 170) of major adverse cardiovascular events (MACE) defined as cardiovascular mortality and admission due to recurrent MI, ischaemic...

  10. Automatic generation of predictive dynamic models reveals nuclear phosphorylation as the key Msn2 control mechanism.

    Science.gov (United States)

    Sunnåker, Mikael; Zamora-Sillero, Elias; Dechant, Reinhard; Ludwig, Christina; Busetto, Alberto Giovanni; Wagner, Andreas; Stelling, Joerg

    2013-05-28

    Predictive dynamical models are critical for the analysis of complex biological systems. However, methods to systematically develop and discriminate among systems biology models are still lacking. We describe a computational method that incorporates all hypothetical mechanisms about the architecture of a biological system into a single model and automatically generates a set of simpler models compatible with observational data. As a proof of principle, we analyzed the dynamic control of the transcription factor Msn2 in Saccharomyces cerevisiae, specifically the short-term mechanisms mediating the cells' recovery after release from starvation stress. Our method determined that 12 of 192 possible models were compatible with available Msn2 localization data. Iterations between model predictions and rationally designed phosphoproteomics and imaging experiments identified a single-circuit topology with a relative probability of 99% among the 192 models. Model analysis revealed that the coupling of dynamic phenomena in Msn2 phosphorylation and transport could lead to efficient stress response signaling by establishing a rate-of-change sensor. Similar principles could apply to mammalian stress response pathways. Systematic construction of dynamic models may yield detailed insight into nonobvious molecular mechanisms.

  11. Application and licensing requirements of the Framatome ANP RLBLOCA methodology

    International Nuclear Information System (INIS)

    Martin, R.P.; Dunn, B.M.

    2004-01-01

    The Framatome ANP Realistic Large-Break LOCA methodology (FANP RLBLOCA) is an analysis approach approved by the US NRC for supporting the licensing basis of 3- and 4-loop Westinghouse PWRs and CE 2x4 PWRs. It was developed consistent with the NRC's Code Scaling, Applicability, and Uncertainty (CSAU) methodology for performing best-estimate large-break LOCAs. The CSAU methodology consists of three key elements with the second and third element addressing uncertainty identification and application. Unique to the CSAU methodology is the use of engineering judgment and the Process Identification and Ranking Table (PIRT) defined in the first element to lay the groundwork for achieving the ultimate goal of quantifying the total uncertainty in predicted measures of interest associated with the large-break LOCA. It is the PIRT that not only directs the methodology development, but also directs the methodology review. While the FANP RLBLOCA methodology was generically approved, a plant-specific application is customized in two ways addressing how the unique plant characterization 1) is translated to code input and 2) relates to the unique methodology licensing requirements. Related to the former, plants are required by 10 CFR 50.36 to define a technical specification limiting condition for operation based on the following criteria: 1. Installed instrumentation that is used in the control room to detect, and indicate, a significant abnormal degradation of the reactor coolant pressure boundary. 2. A process variable, design feature, or operating restriction that is an initial condition of a design basis accident or transient analysis that either assumes the failure of or presents a challenge to the integrity of a fission product barrier. 3. A structure, system, or component that is part of the primary success path and which functions or actuates to mitigate a design basis accident or transient that either assumes the failure of or presents a challenge to the integrity of a

  12. Gemcitabine-loaded albumin nanospheres (GEM-ANPs) inhibit PANC-1 cells in vitro and in vivo

    Science.gov (United States)

    Li, Ji; Di, Yang; Jin, Chen; Fu, Deliang; Yang, Feng; Jiang, Yongjian; Yao, Lie; Hao, Sijie; Wang, Xiaoyi; Subedi, Sabin; Ni, Quanxing

    2013-04-01

    With the development of nanotechnology, special attention has been given to the nanomaterial application in tumor treatment. Here, a modified desolvation-cross-linking method was successfully applied to fabricate gemcitabine-loaded albumin nanospheres (GEM-ANPs), with 110 and 406 nm of mean diameter, respectively. The aim of this study was to assess the drug distribution, side effects, and antitumor activity of GEM-ANPs in vivo. The metabolic viability and flow cytometry analysis revealed that both GEM-ANPs, especially 406-nm GEM-ANPs, could effectively inhibit the metabolism and proliferation and promote the apoptosis of human pancreatic carcinoma (PANC-1) in vitro. Intravenous injection of 406-nm GEM-ANPs exhibited a significant increase of gemcitabine in the pancreas, liver, and spleen of Sprague-Dawley rats ( p PANC-1-induced tumor mice, intravenous injection of 406-nm GEM-ANPs also could effectively reduce the tumor volume by comparison with free gemcitabine. With these findings, albumin nanosphere-loading approach might be efficacious to improve the antitumor activity of gemcitabine, and the efficacy is associated with the size of GEM-ANPs.

  13. Práticas de produção textual no MSN Messenger: ressignificando a escrita colaborativa Text production practices on MSN: redifining collaborative writing

    Directory of Open Access Journals (Sweden)

    Petrilson Alan Pinheiro

    2010-01-01

    Full Text Available Este artigo tem por objetivo articular as práticas de escrita escolarese as tecnologias da comunicação e da informação disponibilizadas na Internet, buscando, com isso, possibilitar um repensar e uma redefinição dos modelos de produção textual com os quais a escola ainda opera. Na tentativa de explorar tal relação, propomos a realização de um trabalho que aponte como o uso de alguns gêneros digitais do ciberespaço, como o MSN Messenger, contribuem para a construção de práticas colaborativas de escrita de alunos do ensino médio. Para tanto, tomaremos como base teórica os construtos bakhtinianos de gêneros do discurso e na teoria situada de gênero (ERICKSON, 1997; Yates; Orlikowski; Rennecker, 1997; SHEPHERD; WATTERS, 1999; Devitt, 2000 para dar conta do comportamento dos gêneros digitais. Trata-se de uma pesquisa empírica realizada com dezesseis aprendizes e um professor do ensino médio de uma escola estadual localizada no município de Campinas _ SP. Os alunos criaram um site para a divulgação de um jornal digital e, para produzir os textos que são expostos nesse jornal, eles fazem uso do e-mail e do MSN Messenger. Como proposta de análise multimodal da produção textual desses aprendizes na Internet, tomaremos como base as metafunções semióticas nos níveis apresentacional, orientacional e organizacional, propostas por Lemke (1995, 1998a, 1998b, como dispositivos teórico-analíticos dos dados gerados a partir dos registros dos diversos modos com que os alunos constroem sentidos ao aprenderem e desenvolverem seus textos de forma colaborativa a partir do uso dos gêneros digitais.The objective of this paper is to articulate school writing practices and the new communication and information technology from the Internet, by searching a way of rethinking and redefining the text production patterns with which schools still deal. In order to explore such relationship, we propose a paper which points out how the use of

  14. Contributions of ANPEd to the consolidation process of Brazilian Postgraduate studies: historical paths and current scenarios

    Directory of Open Access Journals (Sweden)

    Maria Margarida Machado

    2015-07-01

    Full Text Available This article results the bibliographic and documentary search whose the purpose is reconstitute the historicity to search association, in the context of 50 years to the politic institutionalization on Postgraduate in Brazil, with specific emphasis in the ANPEd - National Association of Postgraduate Studies and Research in Education. The analysis was performed based in the recent politics diary association, especially in the monitoring and positioning in the approval of Law 13.005/2014, which deals with the National Education Plan 2014-2024, with reference to Gramsci’s conception of Expanded State. Studies indicate tensions and challenges faced by ANPEd, from the participation of its members in political society, where the formulators change to executors of national policies, while showing the potential and limits of the association to remain as an entity autonomous civil society in defense of a public, free, secular and quality education for all.

  15. Sizewell B cycle 5 core design with Framatome ANP's CASCADE-3D and British Energy's PANTHER

    International Nuclear Information System (INIS)

    Attale, F.; Koegl, J.; Knight, M.; Bryce, P.

    2001-01-01

    Sizewell B Cycle 5 is the first cycle, after 4 cycles with BNFL fuel, with a reload consisting of Framatome ANP HTP (high thermal performance) fuel assemblies. The impact of this fuel vendor change on the Nuclear Design area is that, according to British energy's (BE) practice, the Framatome ANP's nuclear design code system CASCADE-3D is used for the majority of the cycle specific safety case calculations. However, other parts of the safety submission (e.g. 3D transient analyses) are made by using the BE code PANTHER. Before using in parallel two different code systems for reload core licensing extensive comparisons of applied methodologies and obtained results were required to ensure an acceptable level of agreement. (orig.)

  16. Auditing of prices and production cost of petroleum by ANP; Auditoria de precos e custos de producao do petroleo pela ANP

    Energy Technology Data Exchange (ETDEWEB)

    Pizysieznig Filho, Joao; Gutman, Jose; Almeida, Mauricio Cunha [Agencia Nacional de Petroleo, Gas Natural e Biocombustiveis (ANP), Rio de Janeiro, RJ (Brazil)

    2012-07-01

    The institutional developments in the management of the state monopoly of petroleum has as a consequence the need to expand the audit tools of the key available information to assess the collection of governmental participations. The new regulatory framework for oil exploration in the sub salt layer, embodied in the production sharing contracts, shall rely on the audit expertise of prices and production costs which have already been developed in the National Petroleum Agency - ANP. The paper presents the main audit procedures of prices and production costs of oil and natural gas in the ANP. We discuss also some conceptual sensitive issues observed on audit processes of prices and costs such as the distinction between investment costs and operating costs, rental of equipment belonging to related companies, the form of deduction of investments in each phase - exploration and production, depreciation of wells and abandonment expenses. Beyond of recovering governmental participations values, audits have led to improvements in the upstream accounting processes of the regulated agents, allowing, also, the identification of opportunities for normative improvements (author)

  17. The Establishment of a Green Supplier Selection and Guidance Mechanism with the ANP and IPA

    Directory of Open Access Journals (Sweden)

    Chih-Chao Chung

    2016-03-01

    Full Text Available This study aims to establish a green supplier selection and guidance mechanism by integrating the features of an ANP (Analytic Network Process and an IPA (Importance–Performance Analysis to achieve sustainable management for green supply chains. Using an expert survey, this study developed green supplier selection criteria. It adopted an ANP, which allows for interdependencies and feedback between the various criteria, to select competitive green suppliers. Then, it used an IPA, which can analyze the criteria’s significance and performance levels, to provide green suppliers with direction for guidance and improvements. The green supplier selection and guidance mechanism featuring an ANP and IPA is thus established and validated through case studies. The research results showed the following: (1 the green supplier selection criteria comprise a total of 11 performance evaluation criteria from the three dimensions of operation, competence, and environmental consciousness; (2 as shown by the APN evaluation results, environmental benefits, environmental regulations, finance, technological competence, and delivery time are the top five among the overall green criteria of the company; the performance of the various suppliers is thus arranged in order, and the most competitive supplier is selected; (3 an IPA is used to analyze the criteria’s significance and supplier performance levels and to provide the suppliers with suggestions on priority improvements, including implementing the requirements in the environmental regulations, establishing comprehensive financial management procedures, improving corporate technological competence, and consolidating customer service; (4 it is suggested that an ANP and IPA should be integrated in the applications, which could simplify the green supplier selection and guidance mechanisms and increase the efficiency of supplier management, thus creating a three-win situation for the clients, the company, and the

  18. Individual differences in Affective Neuroscience Personality Scale (ANPS) primary emotional traits and depressive tendencies.

    Science.gov (United States)

    Montag, Christian; Widenhorn-Müller, Katharina; Panksepp, Jaak; Kiefer, Markus

    2017-02-01

    The present study investigated individual differences in the Affective Neuroscience Personality Scales (ANPS), representing measures of primary emotional systems, and depressive tendencies in two independent samples. In order to be able to find support for a continuum model with respect to the relation of strength in the cross-species "affective neuroscience" taxonomy of primary emotional systems, we investigated ANPS measured personality traits in a psychologically mostly healthy population (n=614 participants) as well as a sample of clinically depressed people (n=55 depressed patients). In both normal and depressed samples robust associations appeared between higher FEAR and SADNESS scores and depressive tendencies. A similar - albeit weaker - association was observed with lower SEEKING system scores and higher depressive tendencies, an effect again seen in both samples. The study is of cross-sectional nature and therefore only associations between primary emotional systems and depressive tendencies were evaluated. These results show that similar associations between ANPS monitored primary emotional systems and tendencies toward depression can be observed in both healthy and depressed participants. This lends support for a continuum of affective changes accompanying depression, potentially reflecting differences in specific brain emotional system activities in both affectively normal as well as clinically depressed individuals. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Penerapan Cutomer Relationship Management (CRM Dengan Menggunakan Metode Analytic Network Process (ANP Pada Perusahaan Ritel

    Directory of Open Access Journals (Sweden)

    Nofiyati Nofiyati

    2016-01-01

    Full Text Available Retail industry or retail business is a fast-growing business in the midst of global competition conditions. One strategy to attract more consumers are Customer Relationship Management (CRM. The successful implementation of CRM in the enterprise is influenced by several environmental perspectives, strategies, customers and products / services, processes, participants, infrastructure, and information technology are integrated in the framework of Work System (WS. This research was carried out by applying the method of Multiple Criteria Decision Making (MCDM that is able to accommodate the outer and inner linkage from multiple nodes / indicators are considered, namely the Analytical Network Process (ANP to rank the quality of implementation CRM in retail companies and strong influential node / indicator of the best retail among three alternative the consisting of Alfamart, Indomaret and Smesco mart. From the results of application ANP method, obtained the rank quality of implementation CRM in retail companies with first rank is Indomaret the value of 1.0000; and the second is Alfamart with a value 0.9575; and the third is Smesco mart with a value of 0.8034. While node / indicator strong influence on the the best retail is level of chaos, long and short term planning, customer service, system integration, appropriate skills, technical infrastructure, easily of use and accessibility of information.   Keywords: Ritel, Customer Relationship Management (CRM, Analytic Network Process (ANP, Kerangka Work System (WS.

  20. ANP and BNP plasma levels in patients with rheumatic mitral stenosis after percutaneous balloon mitral valvuloplasty

    Directory of Open Access Journals (Sweden)

    Łukasz Mazurkiewicz

    2017-03-01

    Full Text Available Introduction: Atrial (ANP and B-type (BNP natriuretic peptides are hormones secreted by the heart as a response to volume expansion and pressure overload. Aim: To assess the changes of ANP and BNP after percutaneous balloon mitral valvuloplasty (PBMV and to investigate factors associated with endpoints. Material and methods: The study included 96 patients (90.7% females, age 51.6 ±12.2 years with rheumatic mitral valve stenosis (mitral valve area (MVA 1.18 (1.01–1.33 cm2, mean mitral gradient (MMG 8.2 (7.1–9.2 mm Hg, NYHA 2.09 (1.9–2.5. Patients were followed up for 29.1 months for the search of endpoints. Results : The PBMV was successful in all cases. After the procedure MVA increased (1.18–1.78 cm2, p < 0.01 and pulmonary capillary wedge pressure (PCWP decreased (29.8–21.8 mm Hg, p < 0.01. Concentration of ANP significantly rose 30 min after the PBMV (79.2 vs. 134.2 pg/ml, p = 0.012 and dropped significantly after 24 h (134.2 vs. 70.4 pg/ml, p = 0.01. Furthermore, after 36 months concentration of ANP did not differ from the baseline value (p = NS. BNP concentration at day 1 was lower than at baseline (94.5 vs. 80.2 pg/ml, p = 0.032. Moreover, during the follow-up period BNP continued to fall at all time points. In univariate analysis parameters associated with endpoint occurrence were baseline PAP (p = 0.023, baseline PCWP (p = 0.022, baseline NYHA (p = 0.041 and increase in 6-minute walk test (6MWT (p = 0.043. In multivariate analysis the only factor associated with endpoint occurrence was baseline NYHA (HR = 1.52, 95% CI: –1.3–1.91, p = 0.022. Conclusions : Patients with MS had increased levels of both BNP and ANP. Baseline NYHA class was found to be associated with outcomes after the procedure.

  1. Nucleus Accumbens Microcircuit Underlying D2-MSN-Driven Increase in Motivation.

    Science.gov (United States)

    Soares-Cunha, Carina; Coimbra, Bárbara; Domingues, Ana Verónica; Vasconcelos, Nivaldo; Sousa, Nuno; Rodrigues, Ana João

    2018-01-01

    The nucleus accumbens (NAc) plays a central role in reinforcement and motivation. Around 95% of the NAc neurons are medium spiny neurons (MSNs), divided into those expressing dopamine receptor D1 (D1R) or dopamine receptor D2 (D2R). Optogenetic activation of D2-MSNs increased motivation, whereas inhibition of these neurons produced the opposite effect. Yet, it is still unclear how activation of D2-MSNs affects other local neurons/interneurons or input terminals and how this contributes for motivation enhancement. To answer this question, in this work we combined optogenetic modulation of D2-MSNs with in loco pharmacological delivery of specific neurotransmitter antagonists in rats. First, we showed that optogenetic activation of D2-MSNs increases motivation in a progressive ratio (PR) task. We demonstrated that this behavioral effect relies on cholinergic-dependent modulation of dopaminergic signalling of ventral tegmental area (VTA) terminals, which requires D1R and D2R signalling in the NAc. D2-MSN optogenetic activation decreased ventral pallidum (VP) activity, reducing the inhibitory tone to VTA, leading to increased dopaminergic activity. Importantly, optogenetic activation of D2-MSN terminals in the VP was sufficient to recapitulate the motivation enhancement. In summary, our data suggests that optogenetic stimulation of NAc D2-MSNs indirectly modulates VTA dopaminergic activity, contributing for increased motivation. Moreover, both types of dopamine receptors signalling in the NAc are required in order to produce the positive behavioral effects.

  2. Correlations between ANP concentrations in atria, plasma and cerebral structures and sodium chloride preference in Wistar rats

    Directory of Open Access Journals (Sweden)

    Glass H.

    1997-01-01

    Full Text Available We determined whether ANP (atrial natriuretic peptide concentrations, measured by radioimmunoassay, in the ANPergic cerebral regions involved in regulation of sodium intake and excretion and pituitary gland correlated with differences in sodium preference among 40 Wistar male rats (180-220 g. Sodium preference was measured as mean spontaneous ingestion of 1.5% NaCl solution during a test period of 12 days. The relevant tissues included the olfactory bulb (OB, the posterior and anterior lobes of the pituitary gland (PP and AP, respectively, the median eminence (ME, the medial basal hypothalamus (MBH, and the region anteroventral to the third ventricle (AV3V. We also measured ANP content in the right (RA and left atrium (LA and plasma. The concentrations of ANP in the OB and the AP were correlated with sodium ingestion during the preceding 24 h, since an increase of ANP in these structures was associated with a reduced ingestion and vice-versa (OB: r = -0.3649, P<0.05; AP: r = -0.3291, P<0.05. Moreover, the AP exhibited a correlation between ANP concentration and mean NaCl intake (r = -0.4165, P<0.05, but this was not the case for the OB (r = 0.2422. This suggests that differences in sodium preference among individual male rats can be related to variations of AP ANP level. Earlier studies indicated that the OB is involved in the control of NaCl ingestion. Our data suggest that the OB ANP level may play a role mainly in day-to-day variations of sodium ingestion in the individual rat

  3. A Consistent Fuzzy Preference Relations Based ANP Model for R&D Project Selection

    Directory of Open Access Journals (Sweden)

    Chia-Hua Cheng

    2017-08-01

    Full Text Available In today’s rapidly changing economy, technology companies have to make decisions on research and development (R&D projects investment on a routine bases with such decisions having a direct impact on that company’s profitability, sustainability and future growth. Companies seeking profitable opportunities for investment and project selection must consider many factors such as resource limitations and differences in assessment, with consideration of both qualitative and quantitative criteria. Often, differences in perception by the various stakeholders hinder the attainment of a consensus of opinion and coordination efforts. Thus, in this study, a hybrid model is developed for the consideration of the complex criteria taking into account the different opinions of the various stakeholders who often come from different departments within the company and have different opinions about which direction to take. The decision-making trial and evaluation laboratory (DEMATEL approach is used to convert the cause and effect relations representing the criteria into a visual network structure. A consistent fuzzy preference relations based analytic network process (CFPR-ANP method is developed to calculate the preference-weights of the criteria based on the derived network structure. The CFPR-ANP is an improvement over the original analytic network process (ANP method in that it reduces the problem of inconsistency as well as the number of pairwise comparisons. The combined complex proportional assessment (COPRAS-G method is applied with fuzzy grey relations to resolve conflicts arising from differences in information and opinions provided by the different stakeholders about the selection of the most suitable R&D projects. This novel combination approach is then used to assist an international brand-name company to prioritize projects and make project decisions that will maximize returns and ensure sustainability for the company.

  4. Effects of Cognitive Styles on an MSN Virtual Learning Companion System as an Adjunct to Classroom Instructions

    Science.gov (United States)

    Hsieh, Sheng-Wen

    2011-01-01

    This study designed a chatbot system, Confucius, as a MSN virtual learning companion to examine how specific application design variables within educational software affect the learning process of subjects as defined by the cognitive continuum of field-dependent and field-independent learners. 104 college students participated in a 12 week…

  5. Changes of plasma ADM and ANP of pulmonary artery hypertension in patients with obstructive sleep apnea syndrome

    International Nuclear Information System (INIS)

    Gao Zhi; Zhong Jian; Sheng Chunyong; Xu Shouhong

    2005-01-01

    Objective: To explore the incidence of pulmonary artery hypertension (PAH) and changes of plasma adrenomedullin (ADM) and atrial natriuretic polypeptide (ANP) in patients with obstructive sleep apnea syndrome (OSAS). Methods: 32 healthy middle- and elder-aged cases were randomly selected as control group, 61 cases were confirmed clinically with OSAS. The pressure of pulmonary artery was measured with real time gray scale two-dimensional ultrasonic tomography, the blood plasma levels of ADM and ANP were determined with radioimmunoassay method. Results: Among 61 OSAS patients, 26 of them presented with PAH, its incidence in OSAS was 42.6%. The plasma level of ADM in OSAS with non-PAH group had statistical difference compared with control group ( P < 0.05 ) , also there were significant differences between PAH, non-PAH and control group (P<0.001). Concurrently, the plasma level of ANP in OSAS with PAH, non-PAH also had significant differences compared with control group (P<0.001). Conclusions: There was high incidence of PAH in OSAS patients. The plasma levels of ADM and ANP positively correlated with PAH. ANP played a role in the pathophysiologic genesis of PAH. (authors)

  6. Changes of BNP, ANP, ET and CRP levels in the plasma of patients with acute myocardial infarction

    International Nuclear Information System (INIS)

    Du Tongxing; Wang Zizheng; Wang Shukui; Luo Jun

    2004-01-01

    To explore the pathogenesis and provide evidence for the diagnosis, therapy and prognosis of acute myocardial infarction (AMI) by observing the levels of brain natriuretic peptide (BNP), endothelins (ET), C-reactive protein (CRP) and atrial natriuretic peptide (ANP) in plasma of the patients, BNP, ET, CRP and ANP levels in plasma of 46 AMI patients before and after therapy and 30 normal controls were detected by ELISA and immunoradiometric assay, respectively. Results showed that there were significant differences in BNP, ET, CRP and ANP levels in patients with AMI before and after therapy (P 0.05) after thrombolysis and other supporting therapy, the decreased BNP, ET and CRP were still significantly higher than those of control ( P<0.05). The changes of BNP, ANP, ET and CRP indicate that they involved in the occurrence and development of AMI, especially in the formation and disruption of atheromatous plaque and thrombosis. So the detection of BNP, ANP, ET and CRP levels was significant to the diagnosis, therapy and prognosis judgement

  7. Analytic network process (ANP approach for product mix planning in railway industry

    Directory of Open Access Journals (Sweden)

    Hadi Pazoki Toroudi

    2016-08-01

    Full Text Available Given the competitive environment in the global market in recent years, organizations need to plan for increased profitability and optimize their performance. Planning for an appropriate product mix plays essential role for the success of most production units. This paper applies analytical network process (ANP approach for product mix planning for a part supplier in Iran. The proposed method uses four criteria including cost of production, sales figures, supply of raw materials and quality of products. In addition, the study proposes different set of products as alternatives for production planning. The preliminary results have indicated that that the proposed study of this paper could increase productivity, significantly.

  8. Research on the Rural Express Alliance based on ANP improved profit Allocation

    Science.gov (United States)

    Zhuang, Yufeng; Zhang, Bin

    2018-01-01

    Online shopping platform in rural distribution difficulties, leading to rural online shopping market and logistics market development is slow. At present, China Post and other private courier companies are not possible to do. So we need to build distribution alliances. Reasonable profit allocation mechanism is the key to the stable development of this distribution alliance. So we proposed the Shapley Value Method and the ANP Improved Model to allocate profits. Finally, the rationality of the method is proved by numerical analysis before and after using the corrected Shapley Value.

  9. Framatome ANP GmbH concept of Plant Life Management (PLIM)

    International Nuclear Information System (INIS)

    Daeuwel, W.; Biemann, W.; Danisch, R.; Kastner, B.; Meyer, W.; Nopper, H.; Waas, U.; Warnken, L.

    2002-01-01

    The deregulation of the power generation industry has resulted in increased competitive pressure and is forcing operators to improve plant operating economy while maintaining high levels of plant safety. A key factor to meeting this challenge is to apply a comprehensive plant life management (PLIM) approach which addresses all relevant ageing and degradation mechanisms regarding the safety concept, plant component structures and documentation, plant personnel, consumables, operations management system and administrative controls. For this reason, Framatome ANP GmbH has developed an integrated PLIM concept applicable for both new and operating plants and focusing on the safety concept, plant component structures and documentation. (orig.)

  10. STRENGTHENING THE ROLE OF ISLAMIC PAWNSHOP IN ISLAMIC FINANCING FOR MSMES: ANP APPROACH

    Directory of Open Access Journals (Sweden)

    Lydia Edgina

    2017-06-01

    Full Text Available Objectives: aims to strengthen the role of Islamic pawnshop in financing for Micro Small & Medium EnterprisesMethods: analytic network process (ANP approachResults: the main problem of Islamic pawnshop in expansion was its internal. The most priority was on socialization through promotion and advertisement. The appropriate strategy to be executed was marketing strategy to expand Ar-Rum product (financing for MSMEs through sales marketing.Conclusion: the considered action was massive socialization to the societies using effective and efficient marketing strategy.

  11. Mobility Model for Self-Organizing and Cooperative MSN and MANET Systems

    Directory of Open Access Journals (Sweden)

    Andrzej Sikora

    2012-03-01

    Full Text Available Self-organization mechanisms are used for building scalable systems consisting of a huge number of subsystems. In computer networks, self-organizing is especially important in ad hoc networking. A self-organizing ad hoc network is a collection of wireless devices that collaborate with each other to form a network system that adapts to achieve a goal or goals. Such network is often built from mobile devices that may spontaneously create a network and dynamically adapted to changes in an unknown environment. Mobility pattern is a critical element that influences the performance characteristics of mobile sensor networks (MSN and mobile ad hoc networks (MANET. In this paper, we survey main directions to mobility modeling. We describe a novel algorithm for calculating mobility patterns for mobile devices that is based on a cluster formation and an artificial potential function. Finally, we present the simulation results of its application to a rescue mission planning.

  12. Moessbauer spectroscopy of isotope separator implanted sup(119m)Sn in FCC metals

    International Nuclear Information System (INIS)

    Larsen, A.N.; Weyer, G.

    1979-01-01

    Radioactive sup(119m)Sn has been implanted in FCC metals by means of an isotope separator. Moessbauer spectra have been measured for the 24 keV transition of 119 Sn. Large substitutional fractions are found in all cases. A correlation for substitutional lattice sites between the measured isomer shifts of the impurity atoms and the force constants of the host lattices is discussed. Debye-Waller factors determined for substitutional Sn in the host lattices are found to be smaller than values calculated by a simple mass-defect model. For some host metals indications of an influence of radiation damage on the spectra are observed. Defect sites are assigned to Sn in aluminium and lead. Qualitative conclusions on the structures of these defects are drawn from the determined Moessbauer parameters. (author)

  13. High-resolution flood modeling of urban areas using MSN_Flood

    Directory of Open Access Journals (Sweden)

    Michael Hartnett

    2017-07-01

    Full Text Available Although existing hydraulic models have been used to simulate and predict urban flooding, most of these models are inadequate due to the high spatial resolution required to simulate flows in urban floodplains. Nesting high-resolution subdomains within coarser-resolution models is an efficient solution for enabling simultaneous calculation of flooding due to tides, surges, and high river flows. MSN_Flood has been developed to incorporate moving boundaries around nested domains, permitting alternate flooding and drying along the boundary and in the interior of the domain. Ghost cells adjacent to open boundary cells convert open boundaries, in effect, into internal boundaries. The moving boundary may be multi-segmented and non-continuous, with recirculating flow across the boundary. When combined with a bespoke adaptive interpolation scheme, this approach facilitates a dynamic internal boundary. Based on an alternating-direction semi-implicit finite difference scheme, MSN_Flood was used to hindcast a major flood event in Cork City resulting from the combined pressures of fluvial, tidal, and storm surge processes. The results show that the model is computationally efficient, as the 2-m high-resolution nest is used only in the urban flooded region. Elsewhere, lower-resolution nests are used. The results also show that the model is highly accurate when compared with measured data. The model is capable of incorporating nested sub-domains when the nested boundary is multi-segmented and highly complex with lateral gradients of elevation and velocities. This is a major benefit when modelling urban floodplains at very high resolution.

  14. Determining the Real Causes of Financial Crisis in Islamic Economic Perspective: ANP Approach

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    . Ascarya

    2016-04-01

    Full Text Available Objective – The purpose of this study is to determine the real causes of financial crisis from Islamic economic perspective.Methods - This study applies Analytic Network Process (ANP to determine the real causes of financial crisis from Islamic economic perspective to be able to formulate the real solutions to end financial crisis.Results - The ANP results show that the real causes of financial crisis from Islamic economic perspective are Social Instability (EXTERNAL FACTOR, Speculation (MISBEHAVIOR, Ineffective Fiscal System (UNSUSTAINABLE FISCAL SYSTEM, Hedonism (MISBEHAVIOR, Fractional Reserve Banking System (UNSTABLE MONETARY SYSTEM, Political Instability (EXTERNAL FACTOR, Corruption (POOR GOVERNANCE, Interest Rate (UNSTABLE MONETARY SYSTEM, Fiat Money (UNSTABLE MONETARY SYSTEM, and the Wrong Man in the Wrong Place (POOR GOVERNANCE. These main real causes should be removed gradually in order to systematically and gradually improve the stability of financial system so that financial crisis will not reappear again and again in the future.Conclusions - Financial crisis would not happen under Islamic economic system if all Allah’s laws in financial dealings were followed. Financial crisis in conventional economic system could be prevented or lessened by gradually adopting Islamic economic and finance laws and regulations, partly or fully, especially the main pillars of Islamic financial system, namely the prohibition of ribā (usury or interest, prohibition of maysir (gambling and game of chance or speculation and prohibition of gharar (excessive uncertainty, in their many forms.

  15. Classifying Secondary Task Driving Safety Using Method of F-ANP

    Directory of Open Access Journals (Sweden)

    Lisheng Jin

    2015-02-01

    Full Text Available This study was designed to build an evaluation system for secondary task driving safety by using method of Fuzzy Analytic Network Process (F-ANP. Forty drivers completed driving on driving simulator while interacting with or without a secondary task. Measures of fixations, saccades, and vehicle running status were analyzed. According to five experts' opinions, a hierarchical model for secondary task driving safety evaluation was built. The hierarchical model was divided into three levels: goal, assessment dimension, and criteria. Seven indexes make up the level of criteria, and the assessment dimension includes two clusters: vehicle control risk and driver eye movement risk. By method of F-ANP, the priorities of the criteria and the subcriteria were determined. Furthermore, to rank the driving safety, an approach based on the principle of maximum membership degree was adopted. At last, a case study of secondary task driving safety evaluation by forty drivers using the proposed method was done. The results indicated that the application of the proposed method is practically feasible and adoptable for secondary task driving safety evaluation.

  16. PERMASALAHAN PENGEMBANGAN SUKUK KORPORASI DI INDONESIA MENGGUNAKAN METODE ANALYTICAL NETWORK PROCESS (ANP

    Directory of Open Access Journals (Sweden)

    Endri Endri

    2017-03-01

    Full Text Available This paper analyzed the problem of developing corporate sukuk in Indonesia using AnalyticNetwork Process (ANP methodology, proceeded by literature survey and in-depth interviewwith scholars, practitioners, and regulator of Islamic capital market to fully understand the problemand to develop an appropriate ANP network. The cause of this problem could be grouped into fouraspects, namely 1 market player; 2 product characteristic; 3 regulation; and 4 government. Thisresearch found that the problems of developing corporate sukuk in Indonesia could be summed upinto two main causes from market player and regulation aspects, namely the lack of market playerunderstanding and quality of human resource which involved in Islamic capital market, and alsothe uncertainty of tax regulations. The suggested solution was to increase understanding of marketplayer by promoting Islamic capital market intensively, and then providing quality of human resourceby training and education comprehensively, revising tax regulation to avoid double taxation becomethe next solution. Other suggested solution from government aspect was to give support throughissuance sovereign sukuk. Moreover, the most effective policy strategy to overcome the problems ofIslamic capital market, specially in developing corporate sukuk market was by implementing marketdriven strategy, where policies were intended to make market mechanism running well.

  17. QFD-ANP Approach for the Conceptual Design of Research Vessels: A Case Study

    Science.gov (United States)

    Venkata Subbaiah, Kambagowni; Yeshwanth Sai, Koneru; Suresh, Challa

    2016-10-01

    Conceptual design is a subset of concept art wherein a new idea of product is created instead of a visual representation which would directly be used in a final product. The purpose is to understand the needs of conceptual design which are being used in engineering designs and to clarify the current conceptual design practice. Quality function deployment (QFD) is a customer oriented design approach for developing new or improved products and services to enhance customer satisfaction. House of quality (HOQ) has been traditionally used as planning tool of QFD which translates customer requirements (CRs) into design requirements (DRs). Factor analysis is carried out in order to reduce the CR portions of HOQ. The analytical hierarchical process is employed to obtain the priority ratings of CR's which are used in constructing HOQ. This paper mainly discusses about the conceptual design of an oceanographic research vessel using analytical network process (ANP) technique. Finally the QFD-ANP integrated methodology helps to establish the importance ratings of DRs.

  18. Afetividade, ensino e aprendizagem: um estudo no GT20 da ANPEd

    Directory of Open Access Journals (Sweden)

    Elvira Cristina Martins Tassoni

    Full Text Available Este artigo traz um levantamento bibliográfico dos trabalhos apresentados no GT20 - Psicologia da Educação da ANPEd (Associação Nacional de Pós-Graduação e Pesquisa em Educação no período de 2000 a 2010. O objetivo foi rastrear as produções científicas mais recentes que discutem a afetividade e sua relação com os processos de ensino e aprendizagem. Apresenta as perspectivas teóricas em que os estudos sobre a afetividade foram abordados e em que medida tais estudos discutem as influências entre os aspectos afetivos e os processos de ensino e aprendizagem. Os trabalhos foram selecionados segundo os procedimentos metodológicos da análise de conteúdo fundamentada em Bardin (1977. Os resultados permitiram a construção de um panorama a respeito dos estudos sobre afetividade, apontando tendências, períodos em que as discussões sobre o tema foram mais intensas e, sobretudo, demonstrando que tal temática vem marcando presença constante nas discussões das Reuniões Anuais da ANPEd.

  19. Tourism entrepreneurship policy: a hybrid MCDM model combining DEMATEL and ANP (DANP

    Directory of Open Access Journals (Sweden)

    Saeed Jafari-Moghadam

    2017-06-01

    Full Text Available Small and Medium Enterprises (SME’s, and Entrepreneurial businesses (EB play an important role in tourism since tourism has increasingly become the largest economic sector. Entrepreneurships known as a mean of economic development and policymakers are looking for creating a competitive and dynamic entrepreneurial economy. The aim of this study is to present a model for entrepreneurship tourism policy by using entrepreneurship development framework, which interacts with economic development. To this purpose, entrepreneurship policy dimensions are weighted and prioritized by tourism entrepreneurs, tourism policymakers and experts using decision-making trial and evaluation laboratory (DEMATEL technique and Analytical Network Process (ANP technique. First, DEMATEL technique is used to identify complex relationships, and to form a network relationship map. Then, ANP technique is used to calculate the influential weights of policy criteria. Results show that policymakers for entrepreneurship development in tourism need to consider basic requirements factors. In addition, they should improve efficiency enhancer criteria as well as innovation driver criteria. Also, the relationship among dimensions and their influences on each other are illustrated. Using the capabilities of this method, we can determine the casual relationships between dimensions and criteria and identify priorities for policy.

  20. The nuclear power challenge: the role of the new Framatome ANP

    International Nuclear Information System (INIS)

    Gueldner, R.

    2001-01-01

    Nuclear power will contribute a decisive share to the future electricity supply. It meets sustainability requirements in terms of continuity of supply, resource conservation and climate protection, and recent developments in the United States are revealing clearcut economic benefits. In response to trends on the market, the merger of the nuclear activities of Framatome and Siemens to Framatome ANP early this year has created a global company. It is active in all nuclear markets, such as construction projects, upgrading, nuclear fuels and service. Three regional companies in France, Germany, and USA offer services worldwide of the four corporate divisions, i.e. Projects and Engineering, Nuclear Service, Nuclear Fuel, and Mechanical Components. The German regional company, Framatome ANP GmbH, has its head office in Erlangen and, through its subsidiaries Advanced Nuclear Fuels GmbH (ANF), has expertise in fuel fabrication and, through intelligeNDT Systems and Services GmbH and Co. KG, in non-destructive testing in nuclear technology and HiTec industries. (orig.) [de

  1. Isolated insular strokes and plasma MR-proANP levels are associated with newly diagnosed atrial fibrillation: a pilot study.

    Directory of Open Access Journals (Sweden)

    Karl Frontzek

    Full Text Available In this study, we assessed the relationship of insular strokes and plasma MR-proANP levels with newly diagnosed atrial fibrillation (NDAF.This study is based on a prospective acute stroke cohort (http://www.clinicaltrials.gov, NCT00390962. Patient eligibility was dependent on the diagnosis of acute ischemic stroke, absence of previous stroke based on past medical history and MRI, no history of AF and congestive heart failure (cohort A and, additionally, no stroke lesion size ≥ 20 mL (sub-cohort A*. AF, the primary endpoint, was detected on 24-hour electrocardiography and/or echocardiography. Involvement of the insula was assessed by two experienced readers on MRI blinded to clinical data. MR-proANP levels were obtained through a novel sandwich immunoassay. Logistic-regression-models were fitted to estimate odds ratios for the association of insular strokes and MR-proANP with NDAF. The discriminatory accuracy of insular strokes and MR-proANP was assessed by a model-wise comparison of the area under the receiver-operating-characteristics-curve (AUC with known predictors of AF.104 (cohort A and 83 (cohort A* patients fulfilled above-mentioned criteria. Patients with isolated insular strokes had a 10.7-fold higher odds of NDAF than patients with a small ischemic stroke at any other location. The AUC of multivariate logistic regression models for the prediction of NDAF improved significantly when adding stroke location and MR-proANP levels. Moreover, MR-proANP levels remained significantly elevated throughout the acute hospitalization period in patients with NDAF compared to those without.Isolated insular strokes and plasma MR-proANP levels on admission are independent predictors of NDAF and significantly improve the prediction accuracy of identifying patients with NDAF compared to known predictors including age, the NIHSS and lesion size. To accelerate accurate diagnosis and enhance secondary prevention in acute stroke, higher levels of MR-proANP

  2. Developing a fuzzy ANP model for performance appraisal based on firm strategy

    Directory of Open Access Journals (Sweden)

    Seid Mohammad Reza Mirahmadi

    2018-10-01

    Full Text Available The purpose of this study is to develop a fuzzy Analytic Network Process (ANP model that has the ability to evaluate employee performance in different strategies. A team of experts in the field of strategic human resource management and senior management of an organization engaged in steel production were involved in the study. The data collection tool was a questionnaire that was designed based on the criteria of organization's performance appraisal system. The results showed that in cost leadership strategy, compliance of work hierarchy, quantity of work and the ability to make important decisions constituted the highest coefficients, while in the focus strategy, participate in group work, power of supervision and administration and decision making ability had the highest importance. In differentiation strategy, innovation and creativity, quality and offering constructive suggestions received higher ratings than other criteria. Finally, the developed model was used to evaluate the performance of a sample employee

  3. USING DEMATEL-ANP INTEGRATED APPROACH FOR DECIDING PRODUCTION STRATEGY FOR A PRODUCTION LINE

    Directory of Open Access Journals (Sweden)

    Sinan APAK

    2017-09-01

    Full Text Available Production planning includes push, pull and hybrid production systems that production firms determine their production strategies according to many variables before starting production. The administration of this process requires experience and time. The intensity of rivalry makes this kind of decision processes important, because no firm has the luxury to waste time and to make a wrong decision. In order to solve this problem, research proposes to use integrated decision-making trial and evaluation laboratory (DEMATEL and analytic network process (ANP together which are methods of multi-criteria decision-making models. The process being used to establish which options are found to be most acceptable for operations managers has been demonstrated how applicable it is by using the generated model in automotive industry.

  4. A study on new market development using a hybrid of QFD and ANP

    Directory of Open Access Journals (Sweden)

    Seyedeh Rashedeh Makhzan Mousavi

    2014-07-01

    Full Text Available This paper presents an empirical investigation on new product development (NPD using a hybrid of quality function deployment (QFD and analytical network process (ANP. The study is accomplished in one of the biggest auto producers in Iran named Saipa. The study examines whether or not NDP influences positively on critical success factors (CSF and knowledge management (KM. The study also examines whether KM influences on success of NPD. Using some statistical tests, the study confirms that NDP influences on CSF and KM and there is a positive and meaningful relationship between KM and success of NPD. In addition, the study has prioritized various factors for development of new product development and determined that “technology application consistent with customer’s needs” as well as “Having various meetings with different departments” are the most important factors for the success of new product development.

  5. Selecting e-Purse Smart Card Technology via Fuzzy AHP and ANP

    Directory of Open Access Journals (Sweden)

    Nurgül Demirtaş

    2014-01-01

    Full Text Available Developments in the information technologies provide important advantages to consumers and companies. Nowadays, smart card technology starts to use e-purse applications. The aim of this paper is to identify the most important decision criteria to select the best card technology. In this study, at first smart card and multiple selection techniques were explained. Then the best card technology was selected for an e-purse application. The three types of card technologies were examined and the most important criteria were taken into account by the software developer while they develop card software. Fuzzy analytic hierarchy process (FAHP and analytical network process (ANP techniques were used to compare smart card technologies.

  6. Framatome-ANP extended burnup experience and views on LWR fuels

    International Nuclear Information System (INIS)

    Esteve, B.; Gueldner, R.; Hoffman, R.; Watteau, M.

    2002-01-01

    In every sense of the term, nuclear fuel forms the core of nuclear power plants (NPPs). Although there are many equipment items important for their safety function or for their participation in NPP availability, the fuel, in essence renewable, is one of the key elements which have to be acted upon if utilities are to be helped to fulfil their mission of generating power in total safety and supplying the kWh to their customers at the best price. Nuclear fuel is also the core business of the Framatome-ANP Fuel Business Group: pooling and rationalising the available skills - technical, cultural and human - supplied by each of the partners forms a challenge which it is up to each and every one to meet in a cooperative spirit. This paper gives an outline of the company's extended burnup experience, current R and D, and its plans for the future. (author)

  7. Constructing a Travel Risks’ Evaluation Model for Tour Freelancers Based on the ANP Approach

    Directory of Open Access Journals (Sweden)

    Chin-Tsai Lin

    2016-01-01

    Full Text Available This study constructs a new travel risks’ evaluation model for freelancers to evaluate and select tour groups by considering the interdependencies of the evaluation criteria used. First of all, the proposed model adopts the Nominal Group Technique (NGT to identify suitable evaluation criteria for evaluating travel risks. Six evaluation criteria and 18 subcriteria are obtained. The six evaluation criteria are financial risk, transportation risk, social risk, hygiene risk, sightseeing spot risk, and general risk for freelancer tour groups. Secondly, the model uses the analytic network process (ANP to determine the relative weight of the criteria. Finally, examples of group package tours (GPTs are used to demonstrate the travel risk evaluation process for this model. The results show that the Tokyo GPT is the best group tour. The proposed model helps freelancers to effectively evaluate travel risks and decision-making, making it highly applicable to academia and tour groups.

  8. Profiling and Distribution of Metabolites of Procyanidin B2 in Mice by UPLC-DAD-ESI-IT-TOF-MSn Technique

    OpenAIRE

    Xiao, Ying; Hu, Zhongzhi; Yin, Zhiting; Zhou, Yiming; Liu, Taiyi; Zhou, Xiaoli; Chang, Dawei

    2017-01-01

    The metabolite profiles and distributions of procyanidin B2 were qualitatively described using UPLC-DAD-ESI-IT-TOF-MSn without help of reference standards, and a possible metabolic pathway was proposed in the present study. Summarily, 53 metabolites (24 new metabolites) were detected as metabolites of procyanidin B2, and 45 of them were tentatively identified. Twenty seven metabolites were assigned as similar metabolites of (−)-epicatechin by scission of the flavanol interflavanic bond C4–C8,...

  9. O pensamento de Vygotsky nas reuniões da ANPEd (1998-2003 Vygotsky's thought in the ANPEd meetings (1998 - 2003

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    Maria Teresa de Assunção Freitas

    2004-04-01

    Full Text Available Este artigo analisa os trabalhos fundamentados no pensamento de Vygotsky encontrados da 21ª até a 26ª Reunião Anual da ANPEd, no período de 1998 a 2003, com o objetivo de compreender como esse referencial teórico está sendo apropriado pelos autores participantes desse evento da área da Educação. O texto está organizado em três partes. Em primeiro lugar descreve-se o processo da pesquisa. Em seguida, são apresentados e discutidos os dados quantitativos do material analisado, presentes nas tabelas que figuram em anexo. A terceira parte se constitui em uma análise qualitativa, na qual se explicitam que referências bibliográficas são as mais utilizadas nos trabalhos examinados, que temas e conceitos da abordagem vygotskiana predominam nessa produção e a apropriação da teoria revelada nos textos. Nessa parte são destacados alguns trabalhos em especial, que parecem oferecer uma contribuição mais valiosa para a construção do conhecimento nesse campo, avançando teoricamente e expandindo os conceitos originais do autor em questão. Conclui-se o artigo tecendo algumas reflexões sobre a atual apropriação do pensamento de Vygotsky, revelada nos trabalhos analisados, dialogando com a tese de doutorado da autora, realizada doze anos atrás, que, abordando a mesma temática, focalizou a chegada dos autores da abordagem histórico-cultural no Brasil, o começo da difusão de suas idéias e os esforços iniciais de incorporação de seus conceitos. Finalmente, levantam-se algumas implicações que o estudo feito pode trazer para os educadores brasileiros e estudiosos de Vygotsky.This article analyzes the works based on Vygotsky's thought presented at the annual ANPEd (National Association for Graduate Studies and Research in Education meetings from 1998 to 2003, aiming at an understanding of how that theoretical framework is being incorporated by the authors that participate in those events. The text is organized into three parts

  10. A hybrid multi-criteria decision modeling approach for the best biodiesel blend selection based on ANP-TOPSIS analysis

    Directory of Open Access Journals (Sweden)

    G. Sakthivel

    2015-03-01

    Full Text Available The ever increasing demand and depletion of fossil fuels had an adverse impact on environmental pollution. The selection of appropriate source of biodiesel and proper blending of biodiesel plays a major role in alternate energy production. This paper describes an application of hybrid Multi Criteria Decision Making (MCDM technique for the selection of optimum fuel blend in fish oil biodiesel for the IC engine. The proposed model, Analytical Network Process (ANP is integrated with Technique for Order Performance by Similarity to Ideal Solution (TOPSIS and VlseKriterijumska Optimizacija I Kompromisno Resenje (in Serbian (VIKOR to evaluate the optimum blend. Evaluation of suitable blend is based on the exploratory analysis of the performance, emission and combustion parameters of the single cylinder, constant speed direct injection diesel engine at different load conditions. Here the ANP is used to determine the relative weights of the criteria, whereas TOPSIS and VIKOR are used for obtaining the final ranking of alternative blends. An efficient pair-wise comparison process and ranking of alternatives can be achieved for optimum blend selection through the integration of ANP with TOPSIS and VIKOR. The obtained preference order of the blends for ANP-VIKOR and ANP-TOPSIS are B20 > Diesel > B40 > B60 > B80 > B100 and B20 > B40 > Diesel > B60 > B80 > B100 respectively. Hence by comparing both these methods, B20 is selected as the best blend to operate the internal combustion engines. This paper highlights a new insight into MCDM techniques to evaluate the best fuel blend for the decision makers such as engine manufactures and R& D engineers to meet the fuel economy and emission norms to empower the green revolution.

  11. ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats.

    Science.gov (United States)

    Zheng, Qin; Li, Yulin; Zhang, Dandan; Cui, Xinyuan; Dai, Kuixing; Yang, Yu; Liu, Shuai; Tan, Jichun; Yan, Qiu

    2017-10-26

    Polycystic ovary syndrome (PCOS) is a complicated reproductive endocrine disease characterized by polycystic ovaries, hyperandrogenism and anovulation. It is one of the main causes of infertility. RU486 is an antagonist of progesterone receptor, and most commonly used as a contraceptive. However, whether RU486 is correlated with PCOS remains unclear. Atrial natriuretic peptide (ANP) is a small peptide with natriuretic and diuretic functions, and its availability to be used in PCOS treatment is unknown. Here, we showed that the serum ANP level was lower in PCOS patients than that in healthy women, and it was also decreased in the serum and ovarian tissues of RU486-induced PCOS rats compared with the control rats. We also found that RU486 inhibited the proliferation and promoted the apoptosis of human KGN ovarian granulosa cells by downregulating progesterone receptor membrane component 1 (PGRMC1). Meantime, ANP promoted the proliferation and inhibited the apoptosis of KGN cells through upregulating ANP receptor A (NPRA). The promotive effects of ANP on ovarian functions were mediated through the formation of an NPRA/PGRMC1/EGFR complex, which further activated MAPK/ERK signaling and transcription factor AP1. Moreover, ANP treatment reversed the PCOS symptoms, and improved the fertility of RU486-induced PCOS rats. Collectively, these findings highlight that RU486 is associated with the pathogenesis of PCOS, and ANP treatment may be a promising therapeutic option for PCOS.

  12. Evaluation of patients with portal hypertension using Tc-99m-Sn Colloid scintigraphy

    International Nuclear Information System (INIS)

    Khan, H.A.

    1990-01-01

    Thirty seven cases of portal hypertension with endoscopically proven esophageal varieces underwent liver biopsy to determine the aetiology of portal hypertension. From which 19 had cirrhosis and 18 Idiopathic Portal Hypertension. Tc-99m-Sn colloid static and dynamic scintigraphy of the liver and spleen was performed in these patients. Apart from the calculation of ratio of area (A L/S), ratio of integral (I L/S) were also computed to see if these could be used to differentiate cirrhosis from IPH. Significant difference was noted in the ratio of the area in patients and controls, but the ratios of the integral (IL/S) and the slope of the integral (SIL/S) were not only significantly different in the patients and controls but also in the two groups of patients. The sensitivity of this test when compared with histology was 58% for cirrhosis and IPH but when compared with clinical diagnosis it was 76% for cirrhosis and 62% for IPH group. Therefore, by using the above mentioned technique in the routine study of liver scintigraphy in patients with portal hypertension, the added information obtained can be used to further differentiate the cirrhotic and non cirrhotic group of portal hypertensives. (author)

  13. Replacement of heavy components of the Main Primary System (MPS). Recent innovations made by Framatome ANP

    International Nuclear Information System (INIS)

    Chanussot, J.M.; Thevenet, R.

    2006-01-01

    The replacement of heavy components is the result of widespread stress corrosion of Inconel 600 (and alloys 82/182) in the primary system. Following the corrosion of steam generator tubes, which led to the first steam generator replacement (SGR) operations, work has begun on reactor vessel head replacements (RVHR) and pressurizer replacements, pending treatment of the dissimilar butt welds (DBW). The replacement of sections of the Main Primary System is one way of optimizing plant lifetime besides preventing stress corrosion in primary components and combating phenomena as thermal fatigue or certain metallurgical weaknesses. The increase in the number of major operations carried out in the reactor building on PWR and BWR reactor geometries has called for major technical innovations. AREVA, has over the past twenty years carried out more than forty SGRs throughout the world, including the supply of 115 steam generators of all types. This equates to over 60% of all SGR operations performed in Europe and the USA. Today, most SGR operations are performed in the USA, though some still continue in Europe and Asia. Operations have been planned until 2015. The first RVHR operations were carried out in France in 1993, and have been widespread in Europe since 1996 (Spain and Belgium), and in the USA since 2002 (Davis Besse). Since 1993 AREVA, through its subsidiaries Framatome ANP, Jeumont SA and SGT, has performed 72 RVHRs, i.e. most of those carried out in Europe and the USA. Today, RVHR operations take place throughout the world and have been planned until 2014. The first pressurizer replacement took place in the fall of 2005 in Saint Lucie, USA. Others are to follow (Fort Calhoun, Millestone). A significant number of partial or complete pressurizer replacements are now being scheduled. Special focus must be given to this new operation, as a decision is required between the following types of replacements, taking into account the number of pressurizer heaters and the

  14. Evaluation model of project complexity for large-scale construction projects in Iran - A Fuzzy ANP approach

    Directory of Open Access Journals (Sweden)

    Aliyeh Kazemi

    2016-09-01

    Full Text Available Construction projects have always been complex. By growing trend of this complexity, implementations of large-scale constructions become harder. Hence, evaluating and understanding these complexities are critical. Correct evaluation of a project complication can provide executives and managers with good source to use. Fuzzy analytic network process (ANP is a logical and systematic approach toward defining, evaluation, and grading. This method allows for analyzing complex systems, and determining complexity of them. In this study, by taking advantage of fuzzy ANP, effective indexes for development of complications in large-scale construction projects in Iran have been determined and prioritized. The results show socio-political, project system interdependencies, and technological complexity indexes ranked top to three. Furthermore, in comparison of three main huge projects: commercial-administrative, hospital, and skyscrapers, the hospital project had been evaluated as the most complicated. This model is beneficial for professionals in managing large-scale projects.

  15. Optimization of the scheme for natural ecology planning of urban rivers based on ANP (analytic network process) model.

    Science.gov (United States)

    Zhang, Yichuan; Wang, Jiangping

    2015-07-01

    Rivers serve as a highly valued component in ecosystem and urban infrastructures. River planning should follow basic principles of maintaining or reconstructing the natural landscape and ecological functions of rivers. Optimization of planning scheme is a prerequisite for successful construction of urban rivers. Therefore, relevant studies on optimization of scheme for natural ecology planning of rivers is crucial. In the present study, four planning schemes for Zhaodingpal River in Xinxiang City, Henan Province were included as the objects for optimization. Fourteen factors that influenced the natural ecology planning of urban rivers were selected from five aspects so as to establish the ANP model. The data processing was done using Super Decisions software. The results showed that important degree of scheme 3 was highest. A scientific, reasonable and accurate evaluation of schemes could be made by ANP method on natural ecology planning of urban rivers. This method could be used to provide references for sustainable development and construction of urban rivers. ANP method is also suitable for optimization of schemes for urban green space planning and design.

  16. Comparison of Fuzzy AHP Buckley and ANP Models in Forestry Capability Evaluation (Case Study: Behbahan City Fringe

    Directory of Open Access Journals (Sweden)

    V. Rahimi

    2015-12-01

    Full Text Available The area of Zagros forests is continuously in danger of destruction. Therefore, the remaining forests should be carefully managed based on ecological capability evaluation. In fact, land evaluation includes prediction or assessment of land quality for a special land use with regard to production, vulnerability and management requirements. In this research, we studied the ecological capability of Behbahan city fringe for forestry land use. After the basic studies were completed and the thematic maps such as soil criteria, climate, physiography, vegetation and bedrock were prepared, the fuzzy multi-criteria decision-making methods of Fuzzy AHP Buckley and ANP were used to standardize and determine the weights of criteria. Finally, the ecological model of the region’s capability was generated to prioritize forestry land use and prepare the final map of evaluation using WLC model in seven classes. The results showed that in ANP method, 55.58% of the area is suitable for forestry land use which is more consistent with the reality, while in the Fuzzy AHP method, 95.23% of the area was found suitable. Finally, it was concluded that the ANP method shows more flexibility and ability to determine suitable areas for forestry land use in the study area.

  17. Ranking of Performance Assessment Measures at Tehran Hotel by Combining DEMATEL, ANP, and SERVQUAL Models under Fuzzy Condition

    Directory of Open Access Journals (Sweden)

    Mehrdad Kargari

    2018-01-01

    Full Text Available An effective hybrid model has been proposed by combining ANP, SERVQUAL, and DEMATEL techniques. This model aims to meet different purposes of the hotels and diverse needs of customers at different stages, that is, reservation, reception, accommodation, catering, and check-out. High quality services are ensured when customer expectations have been provided at the expectation level of the customers or beyond that. SERVQUAL model is used to assess the performance of the organizations in terms of five dimensions: responsiveness, empathy, reliability, assurance, and tangibles. Super matrix calculations and pair comparisons required in ANP model have been carried out using DEMATEL model in order to measure the influence of performance assessment measures on each other. In this paper, SERVQUAL model parameters have been considered as the expectations of the hotel clients. Then these customer expectations have been analyzed using DEMATEL model and finally have been ranked using ANP model. Parameters of SERVQUAL model are comprised of verbal and vague criteria in terms of the responses provided by the organizations and customers. This has led to fuzzy conditions in this research. The hybrid model provided better results compared with each individual model, in terms of meeting customer satisfaction and the organization’s objectives.

  18. The Decision Making Trial and Evaluation Laboratory (Dematel) and Analytic Network Process (ANP) for Safety Management System Evaluation Performance

    Science.gov (United States)

    Rolita, Lisa; Surarso, Bayu; Gernowo, Rahmat

    2018-02-01

    In order to improve airport safety management system (SMS) performance, an evaluation system is required to improve on current shortcomings and maximize safety. This study suggests the integration of the DEMATEL and ANP methods in decision making processes by analyzing causal relations between the relevant criteria and taking effective analysis-based decision. The DEMATEL method builds on the ANP method in identifying the interdependencies between criteria. The input data consists of questionnaire data obtained online and then stored in an online database. Furthermore, the questionnaire data is processed using DEMATEL and ANP methods to obtain the results of determining the relationship between criteria and criteria that need to be evaluated. The study cases on this evaluation system were Adi Sutjipto International Airport, Yogyakarta (JOG); Ahmad Yani International Airport, Semarang (SRG); and Adi Sumarmo International Airport, Surakarta (SOC). The integration grades SMS performance criterion weights in a descending order as follow: safety and destination policy, safety risk management, healthcare, and safety awareness. Sturges' formula classified the results into nine grades. JOG and SMG airports were in grade 8, while SOG airport was in grade 7.

  19. Evaluation of power plants in Turkey using Analytic Network Process (ANP)

    International Nuclear Information System (INIS)

    Atmaca, Ediz; Basar, Hasan Burak

    2012-01-01

    Energy is one of the most important parameters of the development of societies. Low cost, clean and secure energy supply is a common issue for all countries. Every country spends commercial and political effort to avoid not having sufficient energy and to ensure an uninterrupted energy supply. This study attempts to determine the suitability of existing power plants in Turkey and the plants that are being considered for establishment in the near future. The alternatives which are being considered are natural gas, wind, geothermal, hydroelectric, and coal/lignite energy plants as well as nuclear energy plants. By using the multi-criteria decision making technique of Analytic Network Process (ANP), a multi-criteria evaluations of six different energy plants were performed with respect to the major criteria such as technology and sustainability, economical suitability, life quality and socio-economic impacts. -- Highlights: ► The study attempted to lay out the criteria based on which power plant investments are evaluated. ► In the energy industry in Turkey and in the world, it is considerably difficult to access data on energy. ► This study will provide significant support for people working in the energy area and related decision makers in Turkey. ► The study is also thought to provide benefit decision makers in the world energy industry. ► It can provide great benefit in ensuring the security of the energy to be produced from power plant investments.

  20. ANALISIS PROBLEMATIKA ZAKAT PADA BAZNAS KOTA TASIKMALAYA:PENDEKATAN METODE ANALYTIC NETWORK PROCESS (ANP

    Directory of Open Access Journals (Sweden)

    Irman Firmansyah

    2014-04-01

    Full Text Available Zakat is an obligation that must be carried out by muzakki that not only aims to carry out obligations to Almighty but sharp-edged nature of social justice among mankind. Therefore charity must be managed properly by the board amilin especially by channeling zakat use specifically targeted at Tasikmalaya City Baznas charity board. The study was to examine the affairs of Baznas perzakatan at Tasikmalaya City. Analysis tool used namely Analysis Network Process (ANP is a qualitative-quantitative method using super decision software . The analysis showed that there is an internal problem which consists of lacking leadership and lacking performance OPZ performance. The problems consist of the absence of external PERDA about channeling zakat institutions and communities less know Baznas. As for an internal solution consisting of leadership and performance maximization of transparency and distribution, while the external solution consisted of socialization and support Baznas scholars. Kendall coefficient ( W ranged from 0.970 to 0.9975 means that all respondents have the same relative answer.

  1. A Fuzzy ANP-SWOT Approach for Analyzing the IT Problems Based on Capabilities in Iran

    Directory of Open Access Journals (Sweden)

    Mehrdad Nouri Koupaei

    2015-02-01

    Full Text Available Determining strategy, as a very effective tool for policy (and especially science and technology policy, helps governments to be able in the challenges such as globalization and increased competition, and have an appropriate respond in the world today. Although some scattered researches about strategy determining have been conducted in Iran, the purpose of them is to recognize the future of IT and determine a framework for strategy determining. This paper examines the situation of Iran in IT. First, according to the techniques of the strategy formulation, the most important internal and external factors have been identified, then using matrix strengths, weaknesses, opportunities and threats, the organizational strategies have been developed. Fuzzy ANP Methods were used for quantitative analysis. The results were calculated using the Expert Choice Software. Statistical community of this study will be including the experts in the field collected among 400 experts. According to the results, the best strategy for implementation ST Strategy. Therefore, some strategies should be considered such as: Explicit decisions to expand or change of research program, selecting an independent organization as trustee of futures studies projects, explicit decisions to expand or change of research program, definition and implementation of future studies for appropriate infrastructure.

  2. A Hybrid Neutrosophic Group ANP-TOPSIS Framework for Supplier Selection Problems

    Directory of Open Access Journals (Sweden)

    Mohamed Abdel-Basset

    2018-06-01

    Full Text Available One of the most significant competitive strategies for organizations is sustainable supply chain management (SSCM. The vital part in the administration of a sustainable supply chain is the sustainable supplier selection, which is a multi-criteria decision-making issue, including many conflicting criteria. The valuation and selection of sustainable suppliers are difficult problems due to vague, inconsistent and imprecise knowledge of decision makers. In the literature on supply chain management for measuring green performance, the requirement for methodological analysis of how sustainable variables affect each other, and how to consider vague, imprecise and inconsistent knowledge, is still unresolved. This research provides an incorporated multi-criteria decision-making procedure for sustainable supplier selection problems (SSSPs. An integrated framework is presented via interval-valued neutrosophic sets to deal with vague, imprecise and inconsistent information that exists usually in real world. The analytic network process (ANP is employed to calculate weights of selected criteria by considering their interdependencies. For ranking alternatives and avoiding additional comparisons of analytic network processes, the technique for order preference by similarity to ideal solution (TOPSIS is used. The proposed framework is turned to account for analyzing and selecting the optimal supplier. An actual case study of a dairy company in Egypt is examined within the proposed framework. Comparison with other existing methods is implemented to confirm the effectiveness and efficiency of the proposed approach.

  3. [Tick-borne diseases].

    Science.gov (United States)

    Tissot Dupont, H; Raoult, D

    1993-05-01

    Due to their worldwide distribution, from hottest to coldest climates, and due to their behaviour, ticks are capable of transmitting numerous human and animal bacterial viral or parasitous diseases. Depending on the disease, they play the role of biological vector or intermediate host. In France, six tick borne diseases are of epidemiologic importance. Q fever (not often tick-borne), Mediterranean Spotted Fever, Lyme disease, Turalemia (human and animal), Babesiosis and Tick-borne Viral Encephalitis.

  4. Numerical simulation of residual stress in piping components at Framatome-ANP

    International Nuclear Information System (INIS)

    Gilies, P.; Franco, C.; Cipiere, M.-F.; Ould, P.

    2005-01-01

    Numerous manufacturing processes induce residual stresses and distortions in piping components and associated welds: quenching of cast pipings, machining and welding. In Pressurized Water Reactors, most of the components have a large thickness for sustaining pressure and distortions are a minor source of concern. This is not the case for residual stresses which may have a strong influence on several type of damage such as fatigue, corrosion, brittle fracture. In low toughness components, residual stress fields may contribute to ductile tearing initiation. These potential damages are mitigated after welding by stress relief heat treatment, which is applied in a systematic manner to ferritic components of the primary system in nuclear reactors. This treatment is not applied on austenitic piping for which the heat treatment temperature is limited due to the risk of sensitization and residual stresses are difficult to eliminate completely. Since on site measurements are costly and difficult to perform, numerical simulation appears to be an attractive tool for estimating residual stress distributions. Framatome-ANP is working on modelling manufacturing processes with that purpose in mind. This paper presents three kinds of applications illustrating efforts on welding, quenching and machining simulation. First a comparison is shown between computations and measurements of residual stress induced by welding of a dissimilar weld metal junction. Then numerical simulations of quenching of a cast stainless steel nozzle are presented. Finally quenching followed by machining and grinding of this cast component are considered in a full simulation of the manufacturing process. Computed distortions and residual stresses are compared with experimental measurements at different stages of the manufacturing process. (authors)

  5. Within AREVA, FRAMATOME ANP and its worldwide experience with PWR and BWR fuels

    International Nuclear Information System (INIS)

    Watteau, Michel; Esteve, Bernard; Giese, Ulrich; Matheson, John

    2002-01-01

    Faced with obvious energy procurement security needs and the increasing concern about global warming, many countries are making a lucid analysis of their energy situation and reconsidering the multiple assets of nuclear energy. After the European Commission's Green Paper evaluation which was endorsed by the European Parliament, the United States gave a strong signal to the whole world by deciding to extent the operating life time of its existing NPPs and by envisioning the construction of new ones. In Asia, here in Korea, and in Japan, the People's Republic of China, Taiwan, large-scale nuclear power plant programs are being pursued. It was in this context, with the aim of ever-greater competitiveness, that the AREVA group was conceived. The aim is for all our skills to have a higher profile on the international markets, so that we are in a stronger position to develop a leadership in our two main high tech sectors of interconnect - electronics and nuclear. In the nuclear sector, the pooling of the Cogema and Framatome ANP forces is enabling AREVA to offer a comprehensive service package ranging from uranium mining to decommissioning, encompassing the design and construction of plants and their fuel; AREVA's experience is grounded in unequalled know-how. Further, with the CEA, a multidisciplinary research organization in charge of anticipating the emerging technologies, as a close partner, AREVA has a unique strategic vision. With this set-up, AREVA has the financial resources it needs to forge the alliances necessary for its development, so that it can best confront international competition and meet the requirements of its customers world-wide

  6. Urban Plan and Water Infrastructures Planning: A Methodology Based on Spatial ANP

    Directory of Open Access Journals (Sweden)

    Michele Grimaldi

    2017-05-01

    Full Text Available Cities are exploding, occupying rural territory in dispersed and fragmented ways. A consequence of this phenomenon is that the demand for utilities includes more and more extensive territories. Among them, fulfilling the demand for services related to integrated water service presents many difficulties. The economic costs needed to meet service demand and the environmental costs associated with its non-fulfilment are inversely proportional to the population needing service in rural areas, since that population is distributed across a low-density gradient. Infrastructure planning, within the area of competence, generally follows a policy of economic sustainability, fixing a service coverage threshold in terms of a “sufficient” concentration of population and economic activity (91/271/CEE. This threshold, homogenous within the territorial limits of a water infrastructure plan, creates uncertainty in the planning of investments, which are not sized on the actual, appropriately spatialized, demand for service. Careful prediction of the location of infrastructure investments would guarantee not only economic savings but also reduce the environmental costs generated by the lack of utilities. Therefore, is necessary to create a link between water infrastructure planning and urban planning, which is responsible for the future spatial distribution of service demand. In this study, the relationships between the instruments of regulation and planning are compared by a multi-criteria spatial analysis network (analytic network process (ANP. This method, tested on a sample of a city in southern Italy, allows us to optimize the design and location of the investment needed to meet the service criteria, looking at the actual efficiency of the networks. The result of this application is a suitability map that allows us to validate the criteria for defining urban transformations.

  7. HSF and Msn2/4p can exclusively or cooperatively activate the yeast HSP104 gene.

    Science.gov (United States)

    Grably, Melanie R; Stanhill, Ariel; Tell, Osnat; Engelberg, David

    2002-04-01

    In an effort to understand how an accurate level of stress-specific expression is obtained, we studied the promoter of the yeast HSP104 gene. Through 5' deletions, we defined a 334 bp fragment upstream of the first coding AUG as sufficient and essential for maximal basal activity and a 260 bp fragment as sufficient and essential for heat shock responsiveness. These sequences contain heat shock elements (HSEs) and stress response elements (STREs) that cooperate to achieve maximal inducible expression. However, in the absence of one set of factors (e.g. in msn2Deltamsn4Delta cells) proper induction is obtained exclusively through HSEs. We also show that HSP104 is constitutively derepressed in ras2Delta cells. This derepression is achieved exclusively through activation of STREs, with no role for HSEs. Strikingly, in ras2Deltamsn2Deltamsn4Delta cells the HSP104 promoter is also derepressed, but in this strain derepression is mediated through HSEs, showing the flexibility and adaptation of the promoter. Thus, appropriate transcription of HSP104 is usually obtained through cooperation between the Msn2/4/STRE and the HSF/ HSE systems, but each factor could activate the promoter alone, backing up the other. Transcription control of HSP104 is adaptive and robust, ensuring proper expression under extreme conditions and in various mutants.

  8. Penerapan Metode Analytic Network Process (ANP Untuk Pendukung Keputusan Pemilihan Tema Tugas Akhir (Studi Kasus: Program Studi S1 Informatika ST3 Telkom

    Directory of Open Access Journals (Sweden)

    Dila Nurlaila

    2017-07-01

    Full Text Available Berdasarkan hasil dari survey yang dilakukan terhadap 30 mahasiswa Informatika yang akan mengambil mata kuliah tugas akhir, lebih dari 80% menjawab belum memiliki konsep Tugas Akhir, hal ini menjadi perhatian bahwa masih banyak dari mahasiswa yang belum mengetahui tema Tugas Akhir apa yang akan dambilnya nanti yang sesuai dengan minat dan kompetensinya. Dari hal tersebut akan dilakukan penelitian penerapan metode Analytic Network Process (ANP pada  Pendukung keputusan pemilihan tugas tema Tugas Akhir. ANP merupakan suatu metode dalam decision making yang mempertimbangkan hubungan antar kriteria. Penelitian ini bertujuan untuk menguji tingkat keberhasilan metode ANP dalam mengatasi masalah mahasiswa yang belum mengetahui konsep dari tugas akhir. Langkah pertama, ditentukan kriteria yang menjadi penentu dari pemilihan tema Tugas Akhir di prodi S1 Informatika. Kriteria ini akan dibuat model jaringan ANP menggunakan software super decision dan setiap kriteria akan dilakukan pairwised comparison (perbandingan berpasangan guna untuk mendapatkan pembobotan dari masing – masing kriteria dan sub kriteria. Yang menjadi expert judgement pada pengambil keputusan ini adalah ketua keahlian program studi ICM dan DESTI. Setelah melakukan pengujian dengan membandingkan pilihan secara manual dengan pilihan berdasarkan perhitungan ANP hasilnya sebesar 46,6% tema tugas akhir mahasiswa sesuai dan akurat, hilangnya 53,4% akurasi dikarenakan ketidak sesuaian jawaban mahasiswa saat menentukan nilai peminatan.

  9. Land suitability assessment for wind power plant site selection using ANP-DEMATEL in a GIS environment: case study of Ardabil province, Iran.

    Science.gov (United States)

    Azizi, Ali; Malekmohammadi, Bahram; Jafari, Hamid Reza; Nasiri, Hossein; Amini Parsa, Vahid

    2014-10-01

    Wind energy is a renewable energy resource that has increased in usage in most countries. Site selection for the establishment of large wind turbines, called wind farms, like any other engineering project, requires basic information and careful planning. This study assessed the possibility of establishing wind farms in Ardabil province in northwestern Iran by using a combination of analytic network process (ANP) and decision making trial and evaluation laboratory (DEMATEL) methods in a geographical information system (GIS) environment. DEMATEL was used to determine the criteria relationships. The weights of the criteria were determined using ANP and the overlaying process was done on GIS. Using 13 information layers in three main criteria including environmental, technical and economical, the land suitability map was produced and reclassified into 5 equally scored divisions from least suitable to most suitable areas. The results showed that about 6.68% of the area of Ardabil province is most suitable for establishment of wind turbines. Sensitivity analysis shows that significant portions of these most suitable zones coincide with suitable divisions of the input layers. The efficiency and accuracy of the hybrid model (ANP-DEMATEL) was evaluated and the results were compared to the ANP model. The sensitivity analysis, map classification, and factor weights for the two methods showed satisfactory results for the ANP-DEMATEL model in wind power plant site selection.

  10. Increased NT-proANP predicts risk of congestive heart failure in Cavalier King Charles spaniels with mitral regurgitation caused by myxomatous valve disease.

    Science.gov (United States)

    Eriksson, Anders S; Häggström, Jens; Pedersen, Henrik Duelund; Hansson, Kerstin; Järvinen, Anna-Kaisa; Haukka, Jari; Kvart, Clarence

    2014-09-01

    To evaluate the predictive value of plasma N-terminal pro-atrial natriuretic peptide (NT-proANP) and nitric oxide end-products (NOx) as markers for progression of mitral regurgitation caused by myxomatous mitral valve disease. Seventy-eight privately owned Cavalier King Charles spaniels with naturally occurring myxomatous mitral valve disease. Prospective longitudinal study comprising 312 measurements over a 4.5 year period. Clinical values were recorded, NT-proANP concentrations were measured by radioimmunoassay, and NOx were analyzed colorimetrically. To predict congestive heart failure (CHF), Cox proportional hazards models with time-varying covariates were constructed. The hazard ratio for NT-proANP (per 1000 pmol/l increase) to predict future CHF was 6.7 (95% confidence interval, 3.6-12.5; p 1000 pmol/l was 11 months (95% confidence interval, 5.6-12.6 months), compared to 54 months (46 - infinity) for dogs with concentrations ≤ 1000 pmol/l (p 130 beats per minute) and grade of murmur (≥ 3/6). The risk of CHF due to mitral regurgitation is increased in dogs with blood NT-proANP concentrations above 1000 pmol/l. Measurement of NT-proANP can be a valuable tool to identify dogs that may develop CHF within months. Copyright © 2014 Elsevier B.V. All rights reserved.

  11. Innovative Born Globals

    DEFF Research Database (Denmark)

    Kraus, Sascha; Brem, Alexander; Muench, Miriam

    2017-01-01

    Internationalization is a hot topic in innovation management, whereby the phenomenon of “Born Globals” is still limited to research in the domains of Entrepreneurship and International Management. As business model design plays a key role for Born Globals, we link these two concepts. For this, we...... propose hypotheses about the influence of efficiency-centered and novelty-entered business model design on international firm performance. To test these hypotheses, we performed a quantitative survey with 252 founders of international companies in Germany, Switzerland and Liechtenstein. Additionally, we...... gained further insights through a case study analysis of 11 Born Globals. The results show that business model design matters to international firm performance and the business model design of Born Globals tends to be more efficiency-centered. Based on a multiple case study, we analyzed business models...

  12. A born dreamer

    Indian Academy of Sciences (India)

    Lawrence

    encouraged me to believe that education was the only way to fulfil one's dreams ... liant student, financial constraints prevented him from pursuing. A born ... higher education. .... to fulfil one's dream despite difficulties, which women face. How-.

  13. Quantitative assessment of hepatic and splenic blood flow detected by Tc-99m-Sn colloid liver scintigraphy

    International Nuclear Information System (INIS)

    Narabayashi, Isamu; Nishiyama, Shoji; Sugimura, Kazuro

    1983-01-01

    Quantitative assessment of hepatic and splenic blood flow detected by injecting Tc-99m-Sn colloid as a bolus was performed on 75 patients who were suspected of having liver disease. Using a computer, the hepatic and splenic time-activity curves were analyzed. Hepatic index was calculated as the ratio of arterial to portal blood flow. The peak time of the right kidney was corresponded to the junction of the arterial and portal phases of the hepatic curve. Splenic index was calculated as the ratio of splenic arterial to liver arterial blood flow. Hepatic and splenic indices had elevated in cases of liver cirrhosis and hepatoma than those of normal controls. There was no significant difference in the hepatic and splenic indices among chronic hepatitis, liver metastasis and normal subject. These noninvasive tests for the hepatic and splenic blood flow may be useful in writing a report of liver scintigram because of the added information of the liver. (author)

  14. Food Sustainable Model Development: An ANP Approach to Prioritize Sustainable Factors in the Romanian Natural Soft Drinks Industry Context

    Directory of Open Access Journals (Sweden)

    Răzvan Cătalin Dobrea

    2015-07-01

    Full Text Available The latest developments in natural soft drinks in the Romanian market signal significant changes in consumers’ perceptions of the sustainability concept. While the necessity of preserving natural resources and ensuring a decent level of healthiness seem to be steadily embraced by the Romanian society, the lack of long enough time series to acknowledge this shift render impossible a traditional econometric validation of these recent trends in economic thinking. The large number of European-funded projects for upgrading technology in the Romanian sector of natural soft drinks raises the question whether the learning by doing effect dispersed into the Romanian managers’ investment decision making from the perspective of both economic and food sustainability. This paper presents the construction and the evaluation of an Analytical Network Process (ANP market share model, which emerged from extended in-depth interviews with 10 managers of the main Romanian natural soft drinks producers. This model differs from traditional market share ANP ones since concepts like either food of economic sustainability were considered as significant driving factors. The coincidence between the estimated market share and the actual one, expressed by Saaty’s compatibility index, validate this model and offer comparative numerical weights’ of importance for food or economic sustainability.

  15. Application of ANP and DEMATEL to evaluate the decision-making of municipal solid waste management in Metro Manila.

    Science.gov (United States)

    Tseng, Ming-Lang

    2009-09-01

    A municipal solid waste management (MSW) expert group was consulted in order to mirror how government officials might reach an effective solution regarding municipal solid waste management in Metro Manila. A critical issue regarding this is how the expert group can better evaluate and select a favorable MSW management solution using a series of criteria. MSW management solution selection is a multiple criteria decision-making (MCDM) problem, which requires the consideration of a large number of complex criteria. A robust MCDM method should consider the interactions among these criteria. The analytic network process (ANP) is a relatively new MCDM method which can deal with all kinds of interactions systematically. The Decision Making Trial and Evaluation Laboratory (DEMATEL) not only can convert the relations between cause and effect of criteria into a structural model, but also can be used as a way to handle the inner dependences within a set of criteria. Hence, this paper applies an effective solution based on a combined ANP and DEMATEL method to assist the expert group evaluating different MSW management solutions. According to the results, the best solution is for each city to have its own type of thermal process technology and resource recovery facility before landfill rather than entering a joint venture with enterprises or going into build-operate-transfer projects in order to be able to construct thermal process technologies and resource recovery facilities.

  16. Disaster risk management in prospect mining area Blitar district, East Java, using microtremor analysis and ANP (analytical network processing) approach

    Energy Technology Data Exchange (ETDEWEB)

    Parwatiningtyas, Diyan, E-mail: diane.tyas@gmail.com, E-mail: erlinunindra@gmail.com; Ambarsari, Erlin Windia, E-mail: diane.tyas@gmail.com, E-mail: erlinunindra@gmail.com; Marlina, Dwi, E-mail: diane.tyas@gmail.com, E-mail: erlinunindra@gmail.com; Wiratomo, Yogi, E-mail: diane.tyas@gmail.com, E-mail: erlinunindra@gmail.com [Department of Physics, Faculty of Engineering, Mathematics and Natural Sciences, Indraprasta PGRI University, Nangka Street No. 58C Tanjung Barat, South Jakarta (Indonesia)

    2014-03-24

    Indonesia has a wealth of natural assets is so large to be managed and utilized, either from its own local government and local communities, especially in the mining sector. However, mining activities can change the state of the surface layer of the earth that have a high impact disaster risk. This could threaten the safety and disrupt human life, environmental damage, loss of property, and the psychological impact, sulking to the rule of law no 24 of 2007. That's why we strive to manage and minimize the risk of mine disasters in the region, how to use the method of calculation of Amplification Factor (AF) from the analysis based microtremor sulking Kanai and Nakamura, and decision systems were tested by analysis of ANP. Based on the amplification factor and Analytical Network Processing (ANP) obtained, some points showed instability in the surface layer of a mining area include the site of the TP-7, TP-8, TP-9, TP-10, (Birowo2). If in terms of structure, location indicated unstable due to have a sloping surface layer, resulting in the occurrence of landslides and earthquake risk is high. In the meantime, other areas of the mine site can be said to be a stable area.

  17. Disaster risk management in prospect mining area Blitar district, East Java, using microtremor analysis and ANP (analytical network processing) approach

    International Nuclear Information System (INIS)

    Parwatiningtyas, Diyan; Ambarsari, Erlin Windia; Marlina, Dwi; Wiratomo, Yogi

    2014-01-01

    Indonesia has a wealth of natural assets is so large to be managed and utilized, either from its own local government and local communities, especially in the mining sector. However, mining activities can change the state of the surface layer of the earth that have a high impact disaster risk. This could threaten the safety and disrupt human life, environmental damage, loss of property, and the psychological impact, sulking to the rule of law no 24 of 2007. That's why we strive to manage and minimize the risk of mine disasters in the region, how to use the method of calculation of Amplification Factor (AF) from the analysis based microtremor sulking Kanai and Nakamura, and decision systems were tested by analysis of ANP. Based on the amplification factor and Analytical Network Processing (ANP) obtained, some points showed instability in the surface layer of a mining area include the site of the TP-7, TP-8, TP-9, TP-10, (Birowo2). If in terms of structure, location indicated unstable due to have a sloping surface layer, resulting in the occurrence of landslides and earthquake risk is high. In the meantime, other areas of the mine site can be said to be a stable area

  18. The Application of a Decision-making Approach based on Fuzzy ANP and TOPSIS for Selecting a Strategic Supplier

    Directory of Open Access Journals (Sweden)

    Rajesri Govindaraju

    2015-09-01

    Full Text Available Supplier selection becomes very important when used in the context of strategic partnerships because of the long-term orientation of the relationship. This paper describes the application of a decision-making approach for selecting a strategic partner (supplier. The approach starts with defining a set of criteria that fits the company’s condition. In the next steps, a combination of fuzzy-ANP and TOPSIS methods is used to determine the weight for each criterion and rank all the alternatives. The application of the approach in an Indonesian manufacturing company showed that the three factors that got the highest weight were “geographical location”, “current operating performance”, and “reliability”. Geographical location got the highest weight because it affects many other factors such as reaction to changes in demand, after-sales service, and delivery lead-time. Application of the approach helps decision-makers to gain effectiveness and efficiency in the decision-making process because it facilitates them to express their group’s collective preferences while also providing opportunities for members to express their individual preferences. Future research can be directed at combining qualitative and quantitative criteria to develop the best criteria and methods for the selection of the best suppliers based on fuzzy ANP and TOPSIS.

  19. Estimation of Tree Lists from Airborne Laser Scanning Using Tree Model Clustering and k-MSN Imputation

    Directory of Open Access Journals (Sweden)

    Jörgen Wallerman

    2013-04-01

    Full Text Available Individual tree crowns may be delineated from airborne laser scanning (ALS data by segmentation of surface models or by 3D analysis. Segmentation of surface models benefits from using a priori knowledge about the proportions of tree crowns, which has not yet been utilized for 3D analysis to any great extent. In this study, an existing surface segmentation method was used as a basis for a new tree model 3D clustering method applied to ALS returns in 104 circular field plots with 12 m radius in pine-dominated boreal forest (64°14'N, 19°50'E. For each cluster below the tallest canopy layer, a parabolic surface was fitted to model a tree crown. The tree model clustering identified more trees than segmentation of the surface model, especially smaller trees below the tallest canopy layer. Stem attributes were estimated with k-Most Similar Neighbours (k-MSN imputation of the clusters based on field-measured trees. The accuracy at plot level from the k-MSN imputation (stem density root mean square error or RMSE 32.7%; stem volume RMSE 28.3% was similar to the corresponding results from the surface model (stem density RMSE 33.6%; stem volume RMSE 26.1% with leave-one-out cross-validation for one field plot at a time. Three-dimensional analysis of ALS data should also be evaluated in multi-layered forests since it identified a larger number of small trees below the tallest canopy layer.

  20. The proceedings of farm-in/farm-out adopted by ANP; O processo de solicitacao de 'cessao de direitos' em contratos de concessao sob a otica da ANP

    Energy Technology Data Exchange (ETDEWEB)

    Quintella, Josie; Braga, Luciana [Agencia Nacional do Petroleo, Gas Natural e Biocombustiveis (ANP), Rio de Janeiro, RJ (Brazil)

    2008-07-01

    The opening of the oil and gas market (Constitutional Amendment n. 9, from 1995 and Law n. 9.478/97 - Petroleum Law), inserted in our order some elements and practices already existing in world oil industry, among which we point out the farm in/farm out contracts. It made possible that the company which has the concession of exploratory and production of oil, to give total or partial rights to other participants, through approval of regulatory institution. In Brazil, this practice is identified as 'Cessao de Direitos'. This work will present the proceedings adopted by the National Agency of Petroleum, Natural Gas and Biofuels (ANP) for executing this current practice (89 requests within the last twelve months) in the Brazilian Petroleum Industry. (author)

  1. [Tick borne diseases].

    Science.gov (United States)

    Holzer, B R

    2005-11-01

    It is known for many years that tick-borne diseases have worldwide a high economical impact on farming industry and veterinary medicine. But only in the last twenty years the importance of such diseases were notified in human medicine by the medical community and the public with emerging of the tick borne encephalitis virus and the description of Borrelia burgdorferi. It is often forgotten that many other infectious agents as bacteria, virus, Rickettsia or protozoa can be transmitted by ticks. Such diseases are rarely diagnosed in Europe either they are overlooked and misdiagnosed or they are connected with special professional activities. The development of new regions for tourism with different out door activities (adventure trips, trekking, hunting) leads to an exposure to different tick borne diseases, which are often misdiagnosed.

  2. The Application of the SCT and the ANP Model to Refine the Most Critical ICT Determinants in Minimizing the Digital Divide

    Directory of Open Access Journals (Sweden)

    Ming-Yuan Hsieh

    2014-01-01

    Full Text Available This research cross-employed the social cognition theory (SCT and the analytical network process (ANP model in qualitative analyses and the multiple criteria decision making (MCDM methodology in quantitative measurements to comprehensively re-identify the most critical information communication technology (ICT determinants in minimizing the digital divide (DD. After measuring the complete importance of related priority weight w (eigenvector from the survey results given to various experts, the complete synthetically comparative index numbers (SCIN from the evaluation model used conveyed two distinct consequences. First, the highest SCIN scores for the ANP, F-ANP, and G-ANP models are 0.5516, 0.3771, and 0.4791, respectively, and are located in the “ICT can positively minimize the level of DD” (ICTCPMDD column in the summarized results table. Secondly, the highest evaluated weighted score of assessed criteria of 0.5801 is located in the Diversified Mobile Applications (DMAPP column. From these results, there are two contributive findings that can be deduced. First, ICT indeed proved the determinative influences and interplays in the level of DD which means that the undeveloped, developing, and emerging regions are apparently able to minimize the level of DD by means of the ICT development. Second, the Diversified Mobile Applications (DMAPP is the most critical determinant of ICT in minimizing the level of digital divide.

  3. Plan of development: analysis under the Brazilian petroleum act, the concession agreements and the ANP ordinance 90/2000; Plano de desenvolvimento: analise a luz da Lei do petroleo, dos contratos de concessao e da Portaria n. 90/2000 da ANP

    Energy Technology Data Exchange (ETDEWEB)

    Caroli, Carla [Petroleo Brasileiro S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil)

    2008-07-01

    By the Plan of Development the concessionaire informs the petroleum regulatory agency (Agencia Nacional de Petroleo Gas e Biocombustiveis - ANP) how it intends to produce hydrocarbons from a field which was declared commercially feasible by such a concessionaire. Therefore, the Plan of Development consists of a very important document for ANP to conduct its supervision duties with regard to operations which usually take place during the development of the production. Because of its relevance within the E and P activities regulatory and supervision system in Brazil, the Plan of Development, its content and the requirements for its record before ANP are regulated by the Brazilian Petroleum Act (Lei n. 9.478/97) and also by the Concession Contracts and a government decree issue by the ANP itself (Portaria 90/2000), which approved a technical regulation on the Plan of Development. This essay will take all these rules into consideration in order to provide a summarized, systematic view of the discipline of the Plan of Development under Brazilian laws and regulations. In this sense, this essay intends to analyze not only the requirements for the preparation, presentation and possible changes in the Plan of Development, but also the legal principles applicable to the plan itself and to the conduct of the ANP before the projects presented by the concessionaires in accordance with such rules. (author)

  4. A Hybrid Approach for Evaluating Faulty Behavior Risk of High-Risk Operations Using ANP and Evidence Theory

    Directory of Open Access Journals (Sweden)

    Xia-Zhong Zheng

    2017-01-01

    Full Text Available Hydropower project construction is a high-risk operation, where accidents occur frequently. Moreover, the factors leading to accidents are often human factors, so safety evaluation of these factors for the hydropower projects’ work system is very significant. The Human Factors Analysis and Classification System (HFACS framework is applied to build evaluation system. In the evaluation process, correlation analysis is used to form the intercriteria analysis matrix that helps the decision makers to build impact relation matrix. Factor weights are calculated by the Analytic Network Process (ANP. In the index value determination step, the evidence theory is used to eliminate the conflicts of three decision makers and the index values are then calculated. The faulty behavior risk (FBR assessment value is finally obtained. The proposed method is practical and its applicability is proved by an example.

  5. Evaluating the green practice of food service supply chain management based on fuzzy DEMATEL-ANP model

    Science.gov (United States)

    Li, Xiaoying; Zhu, Qinghua

    2017-01-01

    The question on how to evaluate a company's green practice has recently become a key strategic consideration for the food service supply chain management. This paper proposed a novel hybrid model that combines a fuzzy Decision Making Trial And Evaluation Laboratory(DEMATEL) and Analysis Network Process(ANP) methods, which developed the green restaurant criteria and demonstrated the complicated relations among various criteria to help the food service operation to better analyze the real-world situation and determine the different weight value of the criteria .The analysis of the evaluation of green practices will help the food service operation to be clear about the key measures of green practice to improve supply chain management.

  6. Framatome-ANP France UO2 fuel fabrication. Criticality safety analysis in the light of the JCO accident

    International Nuclear Information System (INIS)

    Doucet, M.; Zheng, S.; Mouton, J.; Porte, R.

    2003-01-01

    In France the 1999' Tokai Mura criticality accident in Japan had a big impact on the nuclear fuel manufacturing facility community. Moreover this accident led to a large public discussion about all the nuclear facilities. The French Safety Authorities made strong requirements to the industrials to revisit completely their safety analysis files mainly those concerning nuclear fuels treatments. The FRAMATOME-ANP production of its French low enriched (5 w/o) UO2 fuel fabrication plant (FBFC/Romans) exceeds 1000 metric tons a year. Special attention was given to the emergency evacuation plan that should be followed in case of a criticality accident. If a criticality accident happens, site internal and external radioprotection requirements need to have an emergency evacuation plan showing the different routes where the absorbed doses will be as low as possible for people. The French Safety Authorities require also an update of the old based neutron source term accounting for state of the art methodology. UO2 blenders units contain a large amount of dry powder strictly controlled by moderation; a hypothetical water leakage inside one of these apparatus is simulated by increasing the water content of the powder. The resulted reactivity insertion is performed by several static calculations. The French IRSN/CEA CRISTAL codes are used to perform these static calculations. The kinetic criticality code POWDER simulates the power excursion versus time and determines the consequent total energy source term. MNCP4B performs the source term propagation (including neutrons and gamma) used to determine the isodose curves needed to define the emergency evacuation plant. This paper deals with the approach FRAMATOME-ANP has taken to assess Safety Authorities demands using the more up to date calculation tools and methodology. (author)

  7. Vector-borne Infections

    Centers for Disease Control (CDC) Podcasts

    2011-04-18

    This podcast discusses emerging vector-borne pathogens, their role as prominent contributors to emerging infectious diseases, how they're spread, and the ineffectiveness of mosquito control methods.  Created: 4/18/2011 by National Center for Emerging Zoonotic and Infectious Diseases (NCEZID).   Date Released: 4/27/2011.

  8. Tick-borne disease.

    Science.gov (United States)

    Bratton, Robert L; Corey, Ralph

    2005-06-15

    Tick-borne diseases in the United States include Rocky Mountain spotted fever, Lyme disease, ehrlichiosis, tularemia, babesiosis, Colorado tick fever, and relapsing fever. It is important for family physicians to consider these illnesses when patients present with influenza-like symptoms. A petechial rash initially affecting the palms and soles of the feet is associated with Rocky Mountain spotted fever, whereas erythema migrans (annular macule with central clearing) is associated with Lyme disease. Various other rashes or skin lesions accompanied by fever and influenza-like illness also may signal the presence of a tick-borne disease. Early, accurate diagnosis allows treatment that may help prevent significant morbidity and possible mortality. Because 24 to 48 hours of attachment to the host are required for infection to occur, early removal can help prevent disease. Treatment with doxycycline or tetracycline is indicated for Rocky Mountain spotted fever, Lyme disease, ehrlichiosis, and relapsing fever. In patients with clinical findings suggestive of tick-borne disease, treatment should not be delayed for laboratory confirmation. If no symptoms follow exposure to tick bites, empiric treatment is not indicated. The same tick may harbor different infectious pathogens and transmit several with one bite. Advising patients about prevention of tick bites, especially in the summer months, may help prevent exposure to dangerous vector-borne diseases.

  9. The selective estrogen receptor modulators (SERMs) raloxifene and tamoxifen improve ANP levels and decrease nuclear translocation of NF-kB in estrogen-deficient rats.

    Science.gov (United States)

    Lamas, Aline Z; Nascimento, Andrews M; Medeiros, Ana Raquel S; Caliman, Izabela F; Dalpiaz, Polyana L M; Firmes, Luciana B; Sousa, Glauciene J; Oliveira, Phablo Wendell C; Andrade, Tadeu U; Reis, Adelina M; Gouvea, Sônia A; Bissoli, Nazaré S

    2017-08-01

    The selective estrogen receptor modulators (SERMs) raloxifene and tamoxifen are used for the treatment of osteoporosis and cancer, respectively, in women. The impairment of both the Atrial Natriuretic Peptide (ANP) cell signaling system and the translocation of nuclear factor-kappa B (NF-kB) to the cell nucleus are associated with detrimental cardiovascular effects and inflammation. The effects of SERMs on these parameters in the cardiac tissue of estrogen-deficient rats has not been reported. We investigated the effects of raloxifene and tamoxifen on ANP signaling, p65 NF-kB nuclear translocation, cardiac histology and contractility. Female rats were divided into five groups: control (SHAM), ovariectomized (OVX), OVX-treated 17-β-estradiol (E), OVX-treated raloxifene (RLX) and OVX-treated tamoxifen (TAM). The treatments started 21days after ovariectomy and continued for 14days. Ovariectomy reduced ANP mRNA in the left atrium (LA), decreased the content of ANP protein in the LA and in plasma, and increased the level of p65 NF-kB nuclear translocation in the left ventricle. Both 17-β-estradiol and SERMs were able to reverse these alterations, which were induced by the estrogen deficient state. The hemodynamic and cardiac structural parameters analyzed in the present work were not modified by the interventions. Our study demonstrates, for the first time, the additional benefits of raloxifene and tamoxifen in an estrogen-deficient state. These include the normalization of plasmatic and cardiac ANP levels and cardiac p65 NF-kB translocation. Therefore, these treatments promote cardiovascular protection and may contribute to the prevention of cardiac dysfunction observed long-term in postmenopausal women. Copyright © 2017. Published by Elsevier Urban & Partner Sp. z o.o.

  10. Search of the chemical change of the sup(119m)Sn (Tsub(1/2) = 293 days) radioactive decay rate

    International Nuclear Information System (INIS)

    Makariunas, K.; Makariuniene, E.; Dragunas, A.

    1983-01-01

    The differences in decay rates of the nuclear isomer sup(119m)Sn (Tsub(1/2) = 293 days; the strongly converted M4 transition) have been measured for different chemical compounds. The experimental results show that the sup(119m)Sn nuclei in the telluride SnTe decay faster than in the metal β-Sn and in the dioxide SnO 2 [the relative change Δlambda/lambda the decay probability lambda is +(3.6+-1.4)x10 -4 ]. No measurable difference between the decay rates of sup(119m)Sn in β-Sn and SnO 2 has been observed [Δlambda/lambda = -(0.1+-1.2)x10 -4 ], irrespective of the great difference in electronic structure of the tin atoms. The results cannot be explained by considering the internal conversion of the valence electrons only. It is necessary to assume that the chemical changes of the decay rate are strongly influenced by the chemical changes of the probabilities of the internal conversion of electrons of the inner shells of the atom. This conclusion is confirmed by theoretical calculations. (Auth.)

  11. Simultaneous separation and identification of oligomeric procyanidins and anthocyanin-derived pigments in raw red wine by HPLC-UV-ESI-MSn.

    Science.gov (United States)

    Pati, S; Losito, I; Gambacorta, G; La Notte, E; Palmisano, F; Zambonin, P G

    2006-07-01

    Samples of raw red wine (Primitivo di Manduria, Apulia, Southern Italy) were analysed without any pre-treatment (except 1:2 dilution with water) using HPLC with detection based on UV absorbance and Electrospray Ionisation Sequential Mass Spectrometry (ESI-MSn, with n = 1-3) in a series configuration. In particular, absorbance at 520 nm was monitored for UV detection in order to identify pigments responsible for wine colour. On the other hand, two subsequent stages of MS detection based on positive ions were adopted. The first consisted of an explorative MS acquisition, aimed at the individuation of the m/z ratios for positively charged compounds; the second was based on fragmentation of the detected ions within an ion trap analyser, followed by MS/MS and, if required, MS3 acquisitions. The synergy between UV detection and MSn analysis led to the identification of 41 pigments, which can be classified into five groups: grape anthocyanins, pyranoanthocyanins, vinyl-linked anthocyanin-flavanol pigments, ethyl-bridged anthocyanin-flavanol pigments and flavanol-anthocyanin compounds. Many isomeric and oligomeric structures were found within each group. A further class of compounds, not absorbing in the visible spectrum, could be also characterised by ESI-MSn and corresponded to B-type procyanidins, i.e. proanthocyanidins arising from C4-->C8/C4-->C6 couplings between catechin or epicatechin units. In particular, oligomeric structures (from dimers to pentamers), often present with several isomers, were identified and their fragmentation patterns clarified.

  12. Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MSn

    Directory of Open Access Journals (Sweden)

    Ping Yang

    2016-09-01

    Full Text Available Taxifolin is a ubiquitous bioactive constituent of foods and herbs. To thoroughly explore its metabolism in vivo, an HPLC-ESI-IT-TOF-MSn method combined with specific metabolite detection strategy was used to detect and identify the metabolites of taxifolin in rats. Of the 191 metabolites tentatively identified, 154 were new metabolites, 69 were new compounds and 32 were dimers. This is the first report of the in vivo biotransformation of a single compound into more than 100 metabolites. Furthermore, acetylamination and pyroglutamic acid conjugation were identified as new metabolic reactions. Seventeen metabolites were found to have various taxifolin-related bioactivities. The potential targets of taxifolin and 63 metabolites were predicted using PharmMapper, with results showing that more than 60 metabolites have the same five targets. Metabolites with the same fragment pattern may have the same pharmacophore. Thus these metabolites may exert the same pharmacological effects as taxifolin through an additive effect on the same drug targets. This observation indicates that taxifolin is bioactive not only in the parent form, but also through its metabolites. These findings enhance understanding of the metabolism and effective forms of taxifolin and may provide further insight of the beneficial effects of taxifolin and its derivatives.

  13. Rapid and Comprehensive Evaluation of (Polyphenolic Compounds in Pomegranate (Punica granatum L. Juice by UHPLC-MSn

    Directory of Open Access Journals (Sweden)

    Daniele Del Rio

    2012-12-01

    Full Text Available The comprehensive identification of phenolic compounds in food and beverages is a crucial starting point for assessing their biological, nutritional, and technological properties. Pomegranate (Punica granatum L. has been described as a rich source of (polyphenolic components, with a broad array of different structures (phenolic acids, flavonoids, and hydrolyzable tannins and a quick, high throughput, and accurate screening of its complete profile is still lacking. In the present work, a method for UHPLC separation and linear ion trap mass spectrometric (MSn characterization of pomegranate juice phenolic fraction was optimized by comparing several different analytical conditions. The best solutions for phenolic acids, anthocyanins, flavonoids, and ellagitannins have been delineated and more than 70 compounds have been identified and fully characterized in less than one hour total analysis time. Twenty-one compounds were tentatively detected for the first time in pomegranate juice. The proposed fingerprinting approach could be easily translated to other plant derived food extracts and beverages containing a wide array of phytochemical compounds.

  14. Nutritional Composition and Antioxidant Capacity in Edible Flowers: Characterisation of Phenolic Compounds by HPLC-DAD-ESI/MSn

    Directory of Open Access Journals (Sweden)

    Inmaculada Navarro-González

    2014-12-01

    Full Text Available Edible flowers are commonly used in human nutrition and their consumption has increased in recent years. The aim of this study was to ascertain the nutritional composition and the content and profile of phenolic compounds of three edible flowers, monks cress (Tropaeolum majus, marigold (Tagetes erecta and paracress (Spilanthes oleracea, and to determine the relationship between the presence of phenolic compounds and the antioxidant capacity. Proximate composition, total dietary fibre (TDF and minerals were analysed according to official methods: total phenolic compounds (TPC were determined with Folin-Ciocalteu’s reagent, whereas antioxidant capacity was evaluated using Trolox Equivalent Antioxidant Capacity (TEAC and Oxygen Radical Absorbance Capacity (ORAC assays. In addition, phenolic compounds were characterised by HPLC-DAD-MSn. In relation to the nutritional value, the edible flowers had a composition similar to that of other plant foods, with a high water and TDF content, low protein content and very low proportion of total fat—showing significant differences among samples. The levels of TPC compounds and the antioxidant capacity were significantly higher in T. erecta, followed by S. oleracea and T. majus. Thirty-nine different phenolic compounds were tentatively identified, with flavonols being the major compounds detected in all samples, followed by anthocyanins and hydroxycynnamic acid derivatives. In T. erecta small proportions of gallotannin and ellagic acid were also identified.

  15. Profiling and Distribution of Metabolites of Procyanidin B2 in Mice by UPLC-DAD-ESI-IT-TOF-MSn Technique

    Directory of Open Access Journals (Sweden)

    Ying Xiao

    2017-05-01

    Full Text Available The metabolite profiles and distributions of procyanidin B2 were qualitatively described using UPLC-DAD-ESI-IT-TOF-MSn without help of reference standards, and a possible metabolic pathway was proposed in the present study. Summarily, 53 metabolites (24 new metabolites were detected as metabolites of procyanidin B2, and 45 of them were tentatively identified. Twenty seven metabolites were assigned as similar metabolites of (−-epicatechin by scission of the flavanol interflavanic bond C4–C8, including 16 aromatic metabolites, 5 conjugated metabolites, 3 ring-cleavage metabolites, and 2 phenylvalerolactone metabolites. Additionally, 14 metabolites were conjugates of free procyanidin B2, comprising 9 methylation metabolites, 8 sulfation metabolites, 5 hydration metabolites, 2 hydroxylation metabolites, 1 hydrogenation metabolites, and 1 glucuronidation metabolites. The results of metabolite distributions in organs indicated that the conjugated reaction of free procyanidin B2 mainly occurred in liver and diversified metabolites forms were observed in small intestine. The metabolic components of procyanidin B2 identified in mice provided useful information for further study of the bioactivity and mechanism of its action.

  16. Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties

    Science.gov (United States)

    Ferreres, Federico; Lopes, Graciliana; Gil-Izquierdo, Angel; Andrade, Paula B.; Sousa, Carla; Mouga, Teresa; Valentão, Patrícia

    2012-01-01

    Purified phlorotannin extracts from four brown seaweeds (Cystoseira nodicaulis (Withering) M. Roberts, Cystoseira tamariscifolia (Hudson) Papenfuss, Cystoseira usneoides (Linnaeus) M. Roberts and Fucus spiralis Linnaeus), were characterized by HPLC-DAD-ESI-MSn. Fucophloroethol, fucodiphloroethol, fucotriphloroethol, 7-phloroeckol, phlorofucofuroeckol and bieckol/dieckol were identified. The antioxidant activity and the hyaluronidase (HAase) inhibitory capacity exhibited by the extracts were also assessed. A correlation between the extracts activity and their chemical composition was established. F. spiralis, the species presenting higher molecular weight phlorotannins, generally displayed the strongest lipid peroxidation inhibitory activity (IC50 = 2.32 mg/mL dry weight) and the strongest HAase inhibitory capacity (IC50 = 0.73 mg/mL dry weight). As for superoxide radical scavenging, C. nodicaulis was the most efficient species (IC50 = 0.93 mg/mL dry weight), followed by F. spiralis (IC50 = 1.30 mg/mL dry weight). These results show that purified phlorotannin extracts have potent capabilities for preventing and slowing down the skin aging process, which is mainly associated with free radical damage and with the reduction of hyaluronic acid concentration, characteristic of the process. PMID:23222802

  17. Tick-Borne Encephalitis (TBE)

    Science.gov (United States)

    ... virus, Siberian tick-borne encephalitis virus, and Far eastern Tick-borne encephalitis virus (formerly known as Russian ... viruses are closely related to TBEV and Far-eastern TBE, and include Omsk hemorrhagic fever virus in ...

  18. Vector borne diseases

    OpenAIRE

    Melillo Fenech, Tanya

    2010-01-01

    A vector-borne disease is one in which the pathogenic microorganism is transmitted from an infected individual to another individual by an arthropod or other agent. The transmission depends upon the attributes and requirements of at least three different Iiving organisms : the pathologic agent which is either a virus, protozoa, bacteria or helminth (worm); the vector, which is commonly an arthropod such as ticks or mosquitoes; and the human host.

  19. Where was Joseph Babinski born?

    Directory of Open Access Journals (Sweden)

    H A G Teive

    2011-01-01

    Full Text Available There is controversy in the neurological literature about where Joseph Babinski was born, including a myth propounded by various important authors that he was born in Lima, Peru. However, according to the most consistent biographical data, he was in fact born in Paris, France, and became a medical celebrity there and in Poland as well as around the world.

  20. ANALISA PEMILIHAN SUPPLIER RAMAH LINGKUNGAN DENGAN METODE ANALYTICAL NETWORK PROCESS (ANP PADA PT KIMIA FARMA PLANT SEMARANG

    Directory of Open Access Journals (Sweden)

    Nia Budi Puspitasari

    2016-02-01

    Full Text Available Indonesia bersama Thailand dan Filipina menguasai pasar industri farmasi Asia Tenggara sebesar 80% serta diperkirakan pasar industri farmasi hingga 2016 akan mencapai nilai 96,1 miliar USD. Dalam menghadapi hal tersebut diperlukan beberapa hal dimana pada saat ini isu mengenai lingkungan sangat menjadi tren masyarakat. Regulasi pemerintah kepada industri mengenai lingkungan dan peningkatan jumlah masyarakat yang beralih kepada green product membuat industri untuk mulai memasukkan aspek lingkungan ke dalam proses industrinya. Pemilihan pemasok merupakan masalah pengambilan keputusan penting agar mendapatkan pemasok yang dapat meningkatkan daya saing perusahaan. Kriteria pemilihan pemasok umumnya hanya didasarkan pada aspek cost, delivery, dan kualitas. Hal tersebut belum sesuai dengan isu lingkungan dan regulasi pemerintah saat ini. Pemilihan green supplier dilakukan pada PT Kimia Farma plant Semarang. Hal tersebut dilakukan karena PT Kimia Farma plant Semarang berkeinginan mengarahkan produk yang dihasilkan ke arah green product. Saat ini PT Kimia Farma plant Semarang mengalami penurunan produksi dalam 2 tahun terakhir dimana pada jangka 5 tahun, PT Kimia Farma melakukan pergantian supplier sebanyak 5 kali. Analisa pemilihan green supplier tersebut dilakukan menggunakan metode Analytichal Network Process (ANP karena ANP merupakan salah satu metode yang mampu merepresentasikan tingkat kepentingan berbagai pihak dengan mempertimbangkan saling keterkaitan antar kriteria dan sub kriteria yang ada. . Pada pemilihan green supplier kriteria kualitas memiliki bobot 0,369, kriteria lingkungan memiliki bobot sebesar 0,246, kriteria harga memiliki bobot 0,159, kriteria pengiriman 0,11 kriteria pelayanan 0,072, dan kriteria hubungan pemasok 0,044. Rekomendasi supplier yang diberikan adalah PT Sejong karena memiliki bobot terbesar yaitu 0,271.     Abstract Indonesia with Thailand and Philippines now lead pharmaceutical industry market of sotheast asia by

  1. Sizewell B cycle 5 core design with Framatome ANP's CASCADE-3D and British Energy's PANTHER

    Energy Technology Data Exchange (ETDEWEB)

    Attale, F.; Koegl, J. [Framatome ANP GmbH, Nuclear Fuel Cycle, Erlangen (Germany); Knight, M.; Bryce, P. [British Energy, Nuclear Technology Branch, Gloucester (United Kingdom)

    2001-07-01

    Sizewell B Cycle 5 is the first cycle, after 4 cycles with BNFL fuel, with a reload consisting of Framatome ANP HTP (high thermal performance) fuel assemblies. The impact of this fuel vendor change on the Nuclear Design area is that, according to British energy's (BE) practice, the Framatome ANP's nuclear design code system CASCADE-3D is used for the majority of the cycle specific safety case calculations. However, other parts of the safety submission (e.g. 3D transient analyses) are made by using the BE code PANTHER. Before using in parallel two different code systems for reload core licensing extensive comparisons of applied methodologies and obtained results were required to ensure an acceptable level of agreement. (orig.)

  2. Vector-borne diseases

    DEFF Research Database (Denmark)

    More, Simon J.; Bicout, Dominique; Bøtner, Anette

    2017-01-01

    After a request from the Europea n Commission, EFSA’s Panel on Animal Health and Welfaresummarised the main characteristics of 36 vector-borne disease s (VBDs) in 36 web-based storymaps.The risk of introduction in the EU through movement of livestock or pets was assessed for eac h of the36 VBDs......-agents for which the rate of introduction wasestimated to be very low, no further asse ssments were made. Due to the uncertainty related to someparameters used for the risk assessment or the instable or unpredictability disease situation in some ofthe source regions, it is recommended to update the assessment when...

  3. Cutaneous leishmaniasis susceptibility mapping using multi-criteria decision-making techniques, analytic hierarchy process (AHP and analytic network process (ANP

    Directory of Open Access Journals (Sweden)

    SEYED VAHID RAZAVI TERMEH

    2018-02-01

    Full Text Available Background & objective:Cutaneous leech is one of the six major diseases and an example of epidemic diseases in tropical regions. Prevalence and spread of this disease is affected by environmental factors and climatic conditions as well as economic, social and cultural issues. In this research, Analytic Hierarchy Process and network analyzes are used to prepare susceptible cutaneous leeches map. Considering high incidence of cutaneous leech in Khuzestan province, Izeh city was selected as a case study.   Materials & Methods: For this purpose, the number of patients affected by this disease in Izeh was obtained from the Provincial Health Center from 2009 to 2014. Information layers of elevation, rainfall, temperature, humidity, distance from river, distance from rural areas and land use were identified as effective parameter and their maps were prepared in GIS environment. Parameters were compared in pairs by using AHP and ANP and weight of each factors determining their impacts was calculated in Expert Choice and Super Decision software. Then these parameters were combined based on their obtained weights in ArcGIS software and the final cutaneous leech map was prepared. Evaluation of these methods was performed using relative operation curve (ROC and 16 points related to leech disease. Result: The results of weighting effective parameters using AHP and ANP showed that the highest weight is related to elevation, temperature and rainfall parameters, respectively. The results of ROC assessment showed that in preparing the map, ANP had an accuracy of 87.8% and AHP had an accuracy of 68.9%. Conclusion:The results of ANP showed that this model had suitable accuracy in preparing susceptible cutaneous leech map and AHP had moderate accuracy in preparing susceptible cutaneous leech map.

  4. Using the Analytic Network Process (ANP) to assess the distribution of pharmaceuticals in hospitals – a comparative case study of a Danish and American hospital

    DEFF Research Database (Denmark)

    Feibert, Diana Cordes; Sørup, Christian Michel; Jacobsen, Peter

    2016-01-01

    Pharmaceuticals are a vital part of patient treatment and the timely delivery of pharmaceuticals to patients is therefore important. Hospitals are complex systems that provide a challenging environment for decision making. Implementing process changes and technologies to improve the pharmaceutical...... distribution process can therefore be a complex and challenging undertaking. A comparative case study was conducted benchmarking the pharmaceutical distribution process at a Danish and US hospital to identify best practices. Using the ANP method, taking tangible and intangible aspects into consideration...

  5. Qualitative Identification of Fentanyl Analogs and Other Opioids in Postmortem Cases by UHPLC-Ion Trap-MSn.

    Science.gov (United States)

    Shoff, Elisa N; Zaney, M Elizabeth; Kahl, Joseph H; Hime, George W; Boland, Diane M

    2017-07-01

    Since 2013, the Miami-Dade County Medical Examiner Department has experienced an increase in the number of opioid-related deaths. The majority of cases coincided with the introduction of fentanyl into the local heroin supply. From 2014 to 2015, Miami-Dade County experienced a near 600% increase in fentanyl-related deaths, followed by an additional 200% increase in 2016. In 2015, two novel fentanyl analogs were identified in medical examiner cases: beta-hydroxythiofentanyl and acetyl fentanyl. In 2016, four additional fentanyl analogs emerged: para-fluoroisobutyryl fentanyl, butyryl fentanyl, furanyl fentanyl and carfentanil, as well as the synthetic opioid U-47700. In order to address this epidemic, a method was developed and validated to identify 44 opioid-related and analgesic compounds in postmortem samples using ultra high performance liquid chromatography ion trap mass spectrometry with MSn capabilities. The limit of detection for all compounds ranged from 0.1 to 5 ng/mL, with a majority having MS3 spectral fragmentation. Blood, urine, liver or brain specimens from ~500 postmortem cases were submitted for analysis based on case history and/or initial screening results. Of those cases, 375 were positive for illicit fentanyl and/or one or more fentanyl analogs. Due to the potency of these compounds, they were almost always included in the cause of death. Worth emphasizing and extremely alarming is the detection of carfentanil in 134 cases, 104 of which were initially missed by gas chromatography mass spectrometry. By incorporating this sensitive, highly specific, and evolving screening procedure into the workflow, the toxicology laboratory continues to effectively assist the medical examiners in determining the cause and manner of death of decedents in Miami-Dade County. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  6. A hybrid MCDM framework combined with DEMATEL-based ANP to evaluate enterprise technological innovation capabilities assessment

    Directory of Open Access Journals (Sweden)

    Meng-Jong Kuan

    2014-08-01

    Full Text Available The efficient evaluation of technological innovation capabilities of enterprises is an important factor to enhance competitiveness. This paper aims to assess and to rank technological innovation evaluation criteria in order to provide a practical insight of systematic analysis by gathering the qualified experts’ opinions combined with three methods of multi-criteria decision making approach. A framework is proposed and uses a novel hybrid multiple criteria decision-making (MCDM model to address the dependence relationships of criteria with the aid of the Decision-Making Trial and Evaluation Laboratory (DEMATEL, analytical network process (ANP and VIKOR (VlseKriterijumska Optimizacija I Kompromisno Resenje. The study reports that the interaction between criteria is essential and influences technological innovation capabilities; furthermore, this ranking development of technological innovation capabilities assessment is also one of key management tools for managements of other related high- tech enterprises. Managers can then judge the need to improve and determine which criteria provide the most effective direction towards improvement.

  7. PT. Tira Austenite, Tbk dan Analisis Kinerja Perusahaan Ekspedisi dalam Perspektif Supply Chain dan Metode Analytic Network Process (ANP

    Directory of Open Access Journals (Sweden)

    Khristian Edi Nugroho Soebandrija

    2015-06-01

    Full Text Available PT. TIRA AUSTENITE, Tbk (PTATbk and other companies in the field of supply chain require coordination pertaining cross functional and cross collaboration. The mentioned collaboration is required especially for Expedition Company. The performance analysis of Expedition Company, including PTATbk is needed to face the global competition. Company contribution generally, and in particular for Empirical Study toward PTATBK can lead to the problem solving and performance improvement, which covers selecting optimal expedition company and efficient time to dispatch product from existing route to be integrated into the core essence of this research pertaining PTATbk. The mentioned research refers to Empirical Study dan Managerial Implications through books and journals as reference in the Research Methodology. The focus of this researchmethodology is the Analytic Network Process (ANP; criteria of Price and Service; and other important criteria that support the performance analysis within PTATbk. Software ARENA Simulation plays vital role in this research that has the conclusion and recommendation toward problem solving and performance improvement that are translated into benefits versus risks and its form of % and the currency of IDR and/or USD.

  8. Human resource development formulation and evaluation in an Iranian Petrochemical Company using ANP and grey relational analysis

    Directory of Open Access Journals (Sweden)

    Ahmad Reza Ghasemi

    2016-07-01

    Full Text Available Today, human capital is considered a key factor of achieving the competitive advantage in different industries. The present study, as an applied and descriptive research, aims at providing formulation and evaluation of human resource development of an Iranian Petrochemical Company (APC. The human resource experts and managers of APC together with university professors of human capital and familiar with local conditions of Khuzestan province, Iran, made up the statistical population of this research. In this connection, first the internal factors (including advantages and disadvantages were identified using human resource excellence indicators. Then, the opportunities and threats of human resource system were found via PESTEL approach. In the next step, the primary strategies were formulated using the strength, weakness, opportunities and threats (SWOT Matrix. The next phases of the study were included evaluation and ranking of human resource development strategies based on analytical network process (ANP multi-criteria decision making method and grey systems theory. According to results of the research, defensive strategies (WT are suggested as the best and most appropriate strategies in human resource area. In other words, the internal and external factors of APC are problematic. Accordingly, APC is expected to adopt WT strategy, minimize the weaknesses, and avoid threats. Subsequent to the above policy, the strategies of WO, ST, and SO are advised to employ.

  9. Chemical profile analysis and comparison of two versions of the classic TCM formula Danggui Buxue Tang by HPLC-DAD-ESI-IT-TOF-MSn.

    Science.gov (United States)

    Zhang, Ya-Zhou; Xu, Feng; Yi, Tao; Zhang, Jian-Ye; Xu, Jun; Tang, Yi-Na; He, Xi-Chen; Liu, Jing; Chen, Hu-Biao

    2014-04-30

    Danggui Buxue Tang (DBT) is a Traditional Chinese Medicine (TCM) formula primarily used to treat symptoms associated with menopause in women. Usually, DBT is composed of one portion of Radix Angelicae Sinensis (RAS) and five portions of Radix Astragali (RA). Clinically, Radix Hedysari (RH) is sometimes used by TCM physicians to replace RA in DBT. In order to verity whether the chemical constituents of the DBT1 (RA:RAS = 5:1, w/w) and DBT2 (RH:RAS = 5:1, w/w) share similarities the chemical profiles of the two DBTs crude extracts and urine samples were analyzed and compared with the aid of HPLC-DAD-ESI-IT-TOF-MSn, which determines the total ion chromatogram (TIC) and multi-stage mass spectra (MSn). Then, the DBT1 and DBT2 were identified and compared on the basis of the TIC and the MSn. In the first experiment (with crude extracts), 69 compounds (C1-C69) were identified from the DBT1; 46 compounds (c1-c46) were identified from the DBT2. In the second experiment(with urine samples), 44 compounds (M1-M44) were identified from the urine samples of rats that had been administered DBT1, and 34 compounds (m1-m34) were identified from the urine samples of rats that had been administered DBT2. Identification and comparison of the chemical compositions were carried out between the DBT1 and DBT2 of the crude extracts and urine samples respectively. Our results showed that the two crude extracts of the DBTs have quite different chemical profiles. The reasons for their differences were that the special astragalosides in DBT1 and the isoflavonoid glycosides formed the malonic acid esters undergo single esterification and acetyl esters undergo acetylation in DBT1. In contrast, the urine from DBT1-treated rats strongly resembled that of DBT2-treated rats. These metabolites originate mainly from formononetin, calycosin and their related glycosides, and they were formed mainly by the metabolic process of reduction, deglycosylation, demethylation, hydrogenation and sulfation. The

  10. Hsf1p and Msn2/4p cooperate in the expression of Saccharomyces cerevisiae genes HSP26 and HSP104 in a gene- and stress type-dependent manner.

    Science.gov (United States)

    Amorós, M; Estruch, F

    2001-03-01

    Saccharomyces cerevisiae possesses several transcription factors involved in the transcriptional activation of stress-induced genes. Among them, the heat shock factor (Hsf1p) and the zinc finger proteins of the general stress response (Msn2p and Msn4p) have been shown to play a major role in stress protection. Some heat shock protein (HSP) genes contain both heat shock elements (HSEs) and stress response elements (STREs), suggesting the involvement of both transcription factors in their regulation. Analysis of the stress-induced expression of two of these genes, HSP26 and HSP104, reveals that the contribution of Hsf1p and Msn2/4p is different depending on the gene and the stress condition.

  11. Tick-borne encephalitis.

    Science.gov (United States)

    Dumpis, U; Crook, D; Oksi, J

    1999-04-01

    Tick-borne encephalitis (TBE) is a zoonotic arbovirus infection endemic to Russia and Eastern and Central Europe. Despite being a common and serious life-threatening disease for which a mass vaccination program was implemented in Austria, there is only limited reference to this disease in the English-language literature. TBE is transmitted to humans usually by the bite of a tick (either Ixodes persulcatus or Ixodes ricinus); occasionally, cases occur following consumption of infected unpasteurized milk. Transmission is seasonal and occurs in spring and summer, particularly in rural areas favored by the vector. TBE is a serious cause of acute central nervous system disease, which may result in death or long-term neurological sequelae. Effective vaccines are available in a few countries. The risk for travelers of acquiring TBE is increasing with the recent rise in tourism to areas of endemicity during spring and summer.

  12. Estágio supervisionado e prática docente: Sentidos das produções discursivas da ANPEd, BDTD e EPENN. Supervised internship and teachers practice: Meanings of the discursive productions of ANPEd, BDTD and EPENN

    Directory of Open Access Journals (Sweden)

    Melo, Maria Julia C. de

    2014-11-01

    Full Text Available This article aims to analyze the meanings assigned to supervised internship and teachers practice on the discursive productions of ANPEd, UFPE’s BDTD and EPENN, Brazil. These meanings are understood as having a dynamic character, always being historically resignified and occupying epistemic and political disputes’ place. Therefore, this article starts with the discussion on the historically established relationship between theory and practice in teachers’ education; it also addresses the dialogue on the challenges of internship; moves forward to the debate about teachers practice, in addition to the publications themselves that were at the same time theoretical and analysis references. Methodologically, this article embraced qualitative approach, analyzing scientific publications from the French perspective of Discourse Analysis. Thus, the published papers bring the internship as an opportunity to establish praxis and dialogue between the several curriculum components. In addition, the internship linked to the reflection’s enunciation presents itself as a place of resignification of teachers practice. The papers also establish links between theory of reflective practice and Marxist slant theory of praxis. Nevertheless, the analyzed productions on internship and teaching practice make use of both conceptions on the attempt to establish the relationship between theory and practice. Este artigo objetiva analisar os sentidos atribuídos ao estágio supervisionado e à prática docente nas produções discursivas da ANPEd, BDTD da UFPE, e EPENN, Brasil. Esses sentidos são compreendidos como tendo um caráter dinâmico, sempre ressignificados historicamente e ocupando o lugar de disputas epistêmicas e políticas. Assim, o artigo inicia com a discussão sobre a relação teoria e prática historicamente construída na formação de professores; investe ainda no diálogo sobre os desafios do estágio; discorrendo com o debate a respeito da pr

  13. Screening and Analysis of the Potential Bioactive Components of Poria cocos (Schw. Wolf by HPLC and HPLC-MSn with the Aid of Chemometrics

    Directory of Open Access Journals (Sweden)

    Ling-Fang Wu

    2016-02-01

    Full Text Available The aim of the present study was to establish a new method based on Similarity Analysis (SA, Cluster Analysis (CA and Principal Component Analysis (PCA to determine the quality of different samples of Poria cocos (Schw. Wolf obtained from Yunnan, Hubei, Guizhou, Fujian, Henan, Guangxi, Anhui and Sichuan in China. For this purpose 15 samples from the different habitats were analyzed by HPLC-PAD and HPLC-MSn. Twenty-three compounds were detected by HPLC-MSn, of which twenty compounds were tentatively identified by comparing their retention times and mass spectrometry data with that of reference compounds and reviewing the literature. The characteristic fragmentations were summarized. 3-epi-Dehydrotumulosic acid (F13, 3-oxo-16α,25-dihydroxylanosta-7,9(11,24(31-trien-21-oic acid (F4, 3-oxo-6,16α-dihydroxylanosta-7,9(11,24(31-trien-21-oic acid (F7 and dehydropachymic acid (F15 were deemed to be suitable marker compounds to distinguish between samples of different quality according to CA and PCA. This study provides helpful chemical information for further anti-tumor activity and active mechanism research on P. cocos. The results proved that fingerprint combined with a chemometric approach is a simple, rapid and effective method for the quality discrimination of P. cocos.

  14. Comparative Analysis of End Point Enzymatic Digests of Arabino-Xylan Isolated from Switchgrass (Panicum virgatum L of Varying Maturities using LC-MSn

    Directory of Open Access Journals (Sweden)

    Michael J. Bowman

    2012-11-01

    Full Text Available Switchgrass (Panicum virgatum L., SG is a perennial grass presently used for forage and being developed as a bioenergy crop for conversion of cell wall carbohydrates to biofuels. Up to 50% of the cell wall associated carbohydrates are xylan. SG was analyzed for xylan structural features at variable harvest maturities. Xylan from each of three maturities was isolated using classical alkaline extraction to yield fractions (Xyl A and B with varying compositional ratios. The Xyl B fraction was observed to decrease with plant age. Xylan samples were subsequently prepared for structure analysis by digesting with pure endo-xylanase, which preserved side-groups, or a commercial carbohydrase preparation favored for biomass conversion work. Enzymatic digestion products were successfully permethylated and analyzed by reverse-phase liquid chromatography with mass spectrometric detection (RP-HPLC-MSn. This method is advantageous compared to prior work on plant biomass because it avoids isolation of individual arabinoxylan oligomers. The use of RP-HPLC- MSn differentiated 14 structural oligosaccharides (d.p. 3–9 from the monocomponent enzyme digestion and nine oligosaccharide structures (d.p. 3–9 from hydrolysis with a cellulase enzyme cocktail. The distribution of arabinoxylan oligomers varied depending upon the enzyme(s applied but did not vary with harvest maturity.

  15. Early Recollections of First-Borns.

    Science.gov (United States)

    Fakouri, M. Ebrahim; Hafner, James L.

    1984-01-01

    Compared the early recollections of 50 first-borns and 98 later-borns. The first-borns mentioned significantly more nonfamily members, illness/injury, hospital/doctor's office. Later-borns mentioned significantly more siblings than did first-borns. Findings were discussed in the context of Adler's personality theory. (JAC)

  16. Linguagens da arte e crianças pequenas: uma leitura da produção da Anped (2007-2011

    Directory of Open Access Journals (Sweden)

    Alessandra Mara Rotta de Oliveira

    2017-07-01

    Full Text Available Resumo: O presente artigo é resultado de uma investigação de cunho documental sobre a produção acadêmica presente nas reuniões anuais da Associação Nacional de Pós-graduação e Pesquisa em Educação (Anped no GT 24, Educação e arte, e no GT 07, Educação de crianças de 0 a 6 anos, no período entre 2007 e 2011. O objetivo principal foi realizar o mapeamento e a análise qualitativa e interpretativa da produção voltada à educação das crianças de 0 a 3 anos de idade e as linguagens da arte. Os resultados apontam para a ausência de trabalhos específicos ao recorte do mapeamento. Assim, entre outros aspectos, indica-se a necessidade do fortalecimento do diálogo entre o GT 24 e o 07 na Anped e a averiguação em outros espaços de notório reconhecimento científico sobre a presença ou não de uma produção acadêmica voltada à temática em questão. Palavras-chave: Linguagens da arte. Crianças pequenas. Educação Infantil.   Abstract: This article is the result of an investigation of scholarly articles presented at the annual meetings of the National Association of Graduate Studies in Education (Anped from the years 2007 to 2011 to Working Group 24, Education and Art and Working Group 7, Early Education for Children from 0 to 6 years old. The main objective was to conduct a mapping and qualitative and interpretive analysis of articles focusing on the education of children from 0 to 3 years old and artistic languages. The study found an absence of specific studies about this issue. This indicates the need to strengthen the dialog between these two working groups at Anped and to look for articles about this issue in other recognized spaces of academic publications. Keywords: Artistic languages. Small children. Early childhood education.   Resumen: El presente artículo es el resultado de una investigación documental sobre la producción académica presente en las reuniones anuales de Anped en el GT 24, Educación y

  17. OCTSL3MSN

    Data.gov (United States)

    National Aeronautics and Space Administration — On August 17, 1996, the Japanese Space Agency (NASDA - National Space Development Agency) launched the Advanced Earth Observing Satellite (ADEOS). ADEOS was in a...

  18. CZCSL3MSN

    Data.gov (United States)

    National Aeronautics and Space Administration — The Coastal Zone Color Scanner Experiment (CZCS) was the first instrument devoted to the measurement of ocean color and flown on a spacecraft. Although other...

  19. A Multi-Criteria Analysis for the Evaluation of Social Housing Proposals: from the Analytic Hierarchy Process (AHP to the Analytic Network Process (ANP

    Directory of Open Access Journals (Sweden)

    Barbara Ferri

    2017-02-01

    Full Text Available Social housing requires appropriate evaluation models of projects, considering them from multiple perspectives: architectural, technical, environmental, economic, financial, paying particular attention to social aspects. The study proposes the use of a multi criteria evaluation model, based on the hierarchical (AHP and network (ANP analysis, as support in decision-making to guide practitioners and policy on the choice among alternative interventions. These methods allow to consider the overall effect of projects on urban system and the different points of view of those concerned, in an integrated and participatory approach. Interesting research perspectives concern the application of these evaluation approaches to case studies related to neighborhoods in which urban planning provides for social housing. The analysis will address the recent proposals for social housing in the city of Pescara (Italy, and in particular the urban transformation that is expected to achieve by means of the Integrated Urban Development Programme on the south-west of the city, whose regeneration was started by the Community Programme Urban 2.   Un’Analisi Multi Criteri per la Valutazione delle Proposte di Housing Sociale: dall’Analytic Hierarchy Process (AHP all’Analytic Network Process (ANP I modelli insediativi di social housing richiedono idonei strumenti valutativi degli interventi immobiliari, considerandoli da molteplici punti di vista: architettonici, urbanistici, ambientali, economici, finanziari, con particolare attenzione agli aspetti sociali. Lo studio propone l’impiego di un modello valutativo multicriteri basato sull’analisi gerarchica (AHP e a rete (ANP, come supporto ai processi decisionali riguardanti la scelta tra interventi alternativi di edilizia residenziale sociale, considerando il loro effetto complessivo sul sistema urbano secondo un approccio integrato e partecipativo. Parole Chiave: analisi multicriteri, edilizia residenziale sociale

  20. Born : vastutustundlikud tulevikus edukad / Kerstin Born ; interv. Kristo Kiviorg

    Index Scriptorium Estoniae

    Born, Kerstin

    2007-01-01

    Vastutustundliku ettevõtluse Euroopa organisatsiooni CSR Europe'i juht Kerstin Born vastab küsimustele ettevõtete vastutustundlikkuse kohta ühiskonnas. Vt. samas: Käivitus vastutustundliku ettevõtluse indeks

  1. PEMILIHAN STRATEGI PEMASARAN PADA PT. NYONYA MENEER DENGAN MENGGUNAKAN PENDEKATAN METODE ANALYTICAL NETWORK PROCESS (ANP DAN TECHNIQUE FOR ORDER PREFERENCE BY SIMILARITY TO AN IDEAL SOLUTION (TOPSIS

    Directory of Open Access Journals (Sweden)

    Ary Arvianto

    2014-01-01

    Full Text Available Dalam mencapai suatu keunggulan kompetitif, suatu perusahaan membutuhkan suatu strategi pemasaran untuk membedakan dan memiliki nilai yang berbeda dari kompetitornya. Karena krusialnya peran strategi pemasaran dalam kelangsungan perusahaan, pihak manajemen akan mengalami kesulitan dalam memilih strategi pemasaran terbaik dari pilihan strategi yang ada. PT. Nyonya Meneer memproduksi banyak jenis produk, salah satu jenis produk unggulannya adalah produk jamu untuk wanita. Penjualan produk jamu wanita tidak menunjukkan peningkatan yang sesuai dengan target, bahkan cenderung stagnan. Kondisi ini menunjukkan bahwa strategi pemasaran yang selama ini diterapkan belum memberikan hasil yang maksimal karena tidak tercapainya target penjualan yang ada. Oleh karena itu, perlu adanya suatu pemilihan strategi pemasaran PT. Nyonya Meneer dengan melihat kriteria-kriteria yang mempengaruhi dalam proses pemilihan strategi pemasaran dengan menggunakan metode Analytical Network Process (ANP dan TOPSIS. Alternatif strategi pemasaran pada penelitian ini berdasarkan strategi generik Porter. Hasil dari penelitian ini adalah bahwa strategi terpilih bagi PT. Nyonya Meneer adalah strategi segmentasi. Segmen yang direkomendasikan adalah wanita remaja hingga dewasa dengan pendapatan menengah dan menengah ke atas. Kata Kunci : analytical network process (ANP, pemilihan strategi pemasaran, strategi generik porter, TOPSIS Abstract In achieving competitive advantage, a company need a marketing strategy in order to differentiate from its competitor. A marketing strategy decision making is essential for marketing strategist to determine the most appropriate marketing strategy in effecient manner. PT. Nyonya Meneer is one of the biggest company that produce jamu in Indonesia. Jamu for women is the most popular product of PT. Nyonya Meneer. Sales of jamu for women does not show desirable increase, even tend to stagnan. It indicates  that current marketing strategy does not give

  2. Born-Infeld Nonlinear Electrodynamics

    International Nuclear Information System (INIS)

    Bialynicki-Birula, I.

    1999-01-01

    This is only a summary of a lecture delivered at the Infeld Centennial Meeting. In the lecture the history of the Born-Infeld nonlinear electrodynamics was presented and some general features of the theory were discussed. (author)

  3. Simultaneous Analysis of Anthocyanin and Non-Anthocyanin Flavonoid in Various Tissues of Different Lotus (Nelumbo) Cultivars by HPLC-DAD-ESI-MSn

    Science.gov (United States)

    Chen, Sha; Xiang, Yue; Deng, Jiao; Liu, Yanling; Li, Shaohua

    2013-01-01

    A validated HPLC-DAD-ESI-MSn method for the analysis of non-anthocyanin flavonoids was applied to nine different tissues of twelve lotus genotypes of Nelumbo nucifera and N. lutea, together with an optimized anthocyanin extraction and separation protocol for lotus petals. A total of five anthocyanins and twenty non-anthocyanin flavonoids was identified and quantified. Flavonoid contents and compositions varied with cultivar and tissue and were used as a basis to divide tissues into three groups characterized by kaempferol and quercetin derivatives. Influences on flower petal coloration were investigated by principal components analyses. High contents of kaempferol glycosides were detected in the petals of N. nucifera while high quercetin glycoside concentrations occurred in N. lutea. Based on these results, biosynthetic pathways leading to specific compounds in lotus tissues are deduced through metabolomic analysis of different genotypes and tissues and correlations among flavonoid compounds. PMID:23646125

  4. INTEGRASI METODE ANP DAN TOPSIS DALAM EVALUASI KINERJA SUPPLIER DAN PENENTUAN PRIORITAS SUPPLIER BAHAN BAKU UTAMA CETAK KORAN PADA PT MASSCOM GRAPHY SEMARANG

    Directory of Open Access Journals (Sweden)

    Darminto Pujotomo

    2017-01-01

      One of the factors that influence the company performance is the presence of suppliers which supplies raw materials. PT Masscom Graphy Semarang is a printing company which has cooperated with several suppliers to ensure continuity of production. Therefore,  supplier performance evaluation conducted by the company is very important to obtain a reliable supplier in the supply of raw materials. The purpose of this research was to identify the supplier performance evaluation criteria and priorities of suppliers in accordance with the company's needs, and determined the priority order of the main raw material supplier for newspaper print. There was 17 sub-criteria used in evaluating the performance of suppliers and prioritization of suppliers. Analytical Network Process (ANP can be used as an alternative to solve a problem that had many interrelated sub-criteria or influence in decision making. Furthermore, the method Technique For Orders Preference by Similarity to Ideal Solution (TOPSIS was used for ranking suppliers. Based on the weighted sub-criteria by using ANP, the most influence subcriteria in determining the priority of suppliers offering price of 0.17227. Furthermore, to the supplier prioritization was done by using the TOPSIS method and obtained the order suppliers for raw materials paper roll was a supplier A, B, C, and D, while the raw material for the ink web was a supplier of L, N, O and M.

  5. INTEGRASI METODE ANALYTICAL NETWORK PROCESS (ANP DAN TECHNIQUE FOR OTHERS PREFERENCE BY SIMILARITY TO IDEAL SOLUTION (TOPSIS DALAM MENENTUKAN PRIORITAS SUPPLIER BAHAN BAKU (Studi Kasus PT Nyonya Meneer Semarang

    Directory of Open Access Journals (Sweden)

    Dyah Ika Rinawati

    2015-01-01

    Full Text Available Salah satu faktor yang mempengaruhi performansi perusahaan adalah keberadaan supplier yang berperan sebagai penyedia bahan baku. Pemilihan supplier merupakan sebuah pengambilan keputusan multi kriteria, karena banyak faktor yang bersifat kualitatif maupun kuantitatif dapat mempengaruhi performansi supplier.  Sehingga tujuan dalam penelitian ini adalah untuk menentukan supplier yang diprioritaskan PT Nyonya Meneer Semarang dalam memenuhi kebutuhan bahan baku jahe, temulawak, kencur, sambiloto dan pegagan. Kemudian dilakukan pengelompokkan 5 item bahan baku dengan menggunakan model Kraljic Portfolio Matrix. Berdasarkan perhitungan diperoleh hasil yakni bahan baku jahe, kencur dan temulawak termasuk kedalam kategori kuadran critical. Metode Analytical Network Process (ANP dapat dijadikan alternatif untuk suatu permasalahan yang memiliki banyak subkriteria yang saling berkaitan atau berpengaruh dalam pengambilan keputusan dan untuk perankingan  supplier dengan metode Technique For Orders Preference by Similarity to Ideal Solution (TOPSIS. Terdapat 13 subkriteria yang digunakan dalam penentuan prioritas supplier. Berdasarkan pembobotan subkriteria dengan menggunakan ANP, subkriteria yang paling besar pengaruhnya dalam penentuan prioritas supplier adalah harga penawaran sebesar 0,2736. Selanjutnya untuk penentuan prioritas supplier dilakukan dengan menggunakan metode TOPSIS dimana bobot subkriteria diperoleh dari pengolahan metode ANP. Kata Kunci : penentuan prioritas supplier, kraljic portfolio matrix, ANP, TOPSIS   Abstract One of the factors that influence the company performance is the presence of suppliers which supplies raw materials. Selection of suppliers is a Multi-Criteria Decison Problem, because many factors are qualitative and quantitative data can affect the performance of suppliers. So the purpose of this research is to determine the priority supplier companies to meet the raw material needs of jahe, temulawak, kencur, sambiloto and

  6. Business Strategy Formulation By Shareholders and Company Management using The Analytical Network Process (ANPBusiness Strategy Formulation by Shareholders and Company Management Using Analytical Network Process (ANP

    Directory of Open Access Journals (Sweden)

    Faizal Faizal

    2016-11-01

    Full Text Available This research aimed to identify the business strategy formulation by the shareholders and the management of the company. Ten companies were selected to be the objects of this research. Those companies were the information technology, telecommunication, printing, mining, construction and chemical companies in Indonesia. The research was conducted by using the Analytical Network Process (ANP and considering the chosen respondents as the decision makers (experts of those companies. The respondents were chosen by using the non-probabilitty sampling method. The result shows that the roles of the company managements are considered m ore influental (0,57143 than the roles of the shareholders (0,28571. From the output of stakeholder’s condition, the best-stratified priority strategies are differentiation (0,600515, cost of leadership (0,230754 and focus (0,168731.

  7. PEMILIHAN STRATEGI PEMASARAN DI KAMPOENG KOPI BANARAN MENGGUNAKAN PENDEKATAN METODE ANALYTICAL NETWORK PROCESS (ANP DAN TECHNIQUE FOR ORDER PREFERENCE BY SIMILARITY TO AN IDEAL SOLUTION (TOPSIS

    Directory of Open Access Journals (Sweden)

    Aries Susanty

    2014-09-01

    Full Text Available Kampoeng Kopi Banaran belum dapat mencapai laba sesuai dengan target yang telah ditetapkan. Diduga hal ini terjadi karena semakin banyaknya pesaing dengan usaha sejenis, seperti Cimory, Kampoeng Rawa, Tlogo Plantation, Salib Putih, dan Umbul Sidomukti serta belum dimilikinya strategi pemasaran yang tepat oleh Kampoeng Kopi Banaran. Selama ini, Kampoeng Kopi Banaran baru memasarkan  produk-produk yang dimilikinya dengan menggunakan website, brosur,  dan promosi mulut ke mulut.  Berdasarkan hal tersebut, penelitian ini bertujuan untuk  mengidentifikasi kriteria dan subkriteria yang tepat bagi penyusunan strategi pemasaran dari Kampoeng Kopi Banaran, menentukan bobot dari setiap kriteria dan subkriteria tersebut, serta mengusulkan strategi pemasaran tertentu berdasarkan kriteria dan subkriteria tersebut. Dalam penelitian ini, terdapat delapan buah kriteria yang digunakan sebagai dasar untuk menyusun strategi pemasaran bagi Kampoeng Kopi Banaran, yaitu Managerial Capabilities (MC, Market Innovation Capabilities (MIC, Customer Linking Capabilities (CLC, Human Resource Assetes (HRA, Reputational Asset (RA, Competition (C, Economy (E, dan Social and cultural (SC. Selanjutnya kedelapan kriteria tersebut akan dijabarkan lagi menjadi sejumlah subkriteria. Metoda yang digunakan untuk menghitung bobot dari kriteria dan subkriteria adalah Analitycal Network Process (ANP; sedangkan metoda yang digunakan untuk penyusunan strategi pemasaran adalah  Technique for Others Reference by Similarity to Ideal Solution (TOPSIS . Data untuk penelitian ini diperoleh dengan melakukan penyebaran kuesioner kepada manager dan bagian marketing Kampoeng Kopi Banaran. Hasil pengolahan data menunjukkan kriteria yang memiliki bobot tertinggi untuk penyusunan strategi pemasaran di Kampoeng Kopi Banaran adalah Managerial Capabilities (MC (0,1897 dan sub kriteria yagn memiliki bobot tertinggi adalah subkriteria brand atau reputasi (0,1277. Selanjutnya, strategi yang terbaik

  8. Analysis of land suitability for urban development in Ahwaz County in southwestern Iran using fuzzy logic and analytic network process (ANP).

    Science.gov (United States)

    Malmir, Maryam; Zarkesh, Mir Masoud Kheirkhah; Monavari, Seyed Masoud; Jozi, Seyed Ali; Sharifi, Esmail

    2016-08-01

    The ever-increasing development of cities due to population growth and migration has led to unplanned constructions and great changes in urban spatial structure, especially the physical development of cities in unsuitable places, which requires conscious guidance and fundamental organization. It is therefore necessary to identify suitable sites for future development of cities and prevent urban sprawl as one of the main concerns of urban managers and planners. In this study, to determine the suitable sites for urban development in the county of Ahwaz, the effective biophysical and socioeconomic criteria (including 27 sub-criteria) were initially determined based on literature review and interviews with certified experts. In the next step, a database of criteria and sub-criteria was prepared. Standardization of values and unification of scales in map layers were done using fuzzy logic. The criteria and sub-criteria were weighted by analytic network process (ANP) in the Super Decision software. Next, the map layers were overlaid using weighted linear combination (WLC) in the GIS software. According to the research findings, the final land suitability map was prepared with five suitability classes of very high (5.86 %), high (31.93 %), medium (38.61 %), low (17.65 %), and very low (5.95 %). Also, in terms of spatial distribution, suitable lands for urban development are mainly located in the central and southern parts of the Ahwaz County. It is expected that integration of fuzzy logic and ANP model will provide a better decision support tool compared with other models. The developed model can also be used in the land suitability analysis of other cities.

  9. Framework for developing a spatial walkability index (SWI) for the light-rail transit (LRT) stations in Kuala Lumpur city centre using analytical network process (ANP) and GIS

    Science.gov (United States)

    Naharudin, Nabilah; Ahamad, Mohd Sanusi S.; Sadullah, Ahmad Farhan Mohd

    2017-10-01

    In support to the nation's goal of developing a liveable city, Malaysian government aims to improve the mobility in Kuala Lumpur by providing good quality transit services across the city. However, the public starts to demand for more than just a connectivity between two points. They want their transit journey to be comfortable and pleasant from the very first mile. The key here is the first and last mile (FLM) of the transit service which defines their journey to access the station itself. The question is, does the existing transit services' FLM satisfy public's needs? Therefore, many studies had emerged in attempt to assess the pedestrian-friendliness. While most of them did base on the pedestrian's perceptions, there were also studies that spatially measured the connectivity and accessibility to various landuses and point of interests. While both can be a good method, their integration could actually produce a better assessment. However, till date, only a few studies had attempted to do so. This paper proposes a framework to develop a Spatial Walkability Index (SWI) by integrating a multicriteria evaluation technique, Analytical Network Process (ANP) and network analysis on geographical information system (GIS) platform. First, ANP will aggregate the degree of importance for each walkability criteria based on the pedestrian's perceptions. Then, the network analysis will use the weighted criteria as attributes to find the walkable routes within half mile radius from each station. The index will be calculated by rationing the total length of walkable routes in respect to the available footpath. The final outcome is a percentage of walkable FLM transit routes for each station which will be named as the SWI. It is expected that the developed framework can be applied in other cities across the globe. It can also be improvised to suit the demand and purpose there.

  10. Bacterial food-borne zoonoses.

    Science.gov (United States)

    Thorns, C J

    2000-04-01

    In many countries of the world, bacterial food-borne zoonotic infections are the most common cause of human intestinal disease. Salmonella and Campylobacter account for over 90% of all reported cases of bacteria-related food poisoning world-wide. Poultry and poultry products have been incriminated in the majority of traceable food-borne illnesses caused by these bacteria, although all domestic livestock are reservoirs of infection. In contrast to the enzootic nature of most Salmonella and Campylobacter infections, Salmonella Enteritidis caused a pandemic in both poultry and humans during the latter half of the 20th Century. Salmonella Typhimurium and Campylobacter appear to be more ubiquitous in the environment, colonising a greater variety of hosts and environmental niches. Verocytotoxin-producing Escherichia coli O157 (VTEC O157) also emerged as a major food-borne zoonotic pathogen in the 1980s and 1990s. Although infection is relatively rare in humans, clinical disease is often severe, with a significant mortality rate among the young and elderly. The epidemiology of VTEC O157 is poorly understood, although ruminants, especially cattle and sheep, appear to be the major source of infection. The dissemination of S. Enteritidis along the food chain is fairly well understood, and control programmes have been developed to target key areas of poultry meat and egg production. Recent evidence indicates that these control programmes have been associated with an overall reduction of S. Enteritidis along the food chain. Unfortunately, existing controls do not appear to reduce the levels of Campylobacter and VTEC O157 infections. Future control strategies need to consider variations in the epidemiologies of food-borne zoonotic infections, and apply a quantitative risk analysis approach to ensure that the most cost-effective programmes are developed.

  11. Emerging Vector-Borne Diseases.

    Science.gov (United States)

    Huntington, Mark K; Allison, Jay; Nair, Dilip

    2016-10-01

    Several mosquito-borne viral infections have recently emerged in North America; West Nile virus is the most common in the United States. Although West Nile virus generally causes a self-limited, flulike febrile illness, a serious neuroinvasive form may occur. Dengue is the most common vector-borne viral disease worldwide, and it has been a significant public health threat in the United States since 2009. Known as breakbone fever for its severe myalgias and arthralgias, dengue may cause a hemorrhagic syndrome. Chikungunya also causes flulike febrile illness and disabling arthralgias. Although meningoencephalitis may occur with chikungunya, bleeding is uncommon. Symptoms of Zika virus infection are similar to those of dengue, but milder. Zika virus increases the risk of fetal brain abnormalities, including microcephaly, if a pregnant woman is infected. Zika virus is spread through Aedes albopictus mosquito bites, is transmitted sexually, and may rarely spread nonsexually from person to person. Diagnosis of these vectorborne infections is clinical and serologic, and treatment is supportive. Other, well-established vector-borne diseases are also important. Ehrlichiosis is a tick-borne bacterial disease that presents as a nonspecific syndrome of fever, headache, malaise, and myalgias. It is diagnosed via blood smear testing, with confirmatory serology. Ehrlichiosis is treated with doxycycline. Rickettsial infections are transmitted by fleas, mites, and ticks, and severity ranges from mild to life threatening. Rocky Mountain spotted fever, the most significant rickettsial infection, is primarily a clinical diagnosis that presents as fever, headache, myalgias, petechial rash, and tick exposure. Doxycycline is effective for rickettsial infections if administered promptly. Vector avoidance strategies are critical to the prevention of all of these infections.

  12. ANP's strategic regarding the government take considering the volumes of recoverable oil and the Brazilian attractiveness for upstream international investments; Estrategia da ANP quanto ao 'government take', considerando o volume recuperavel e a atratividade do Brasil para investimentos internacionais em 'upstream'

    Energy Technology Data Exchange (ETDEWEB)

    Motta, Regis [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Escola Politecnica. Dept. de Engenharia Industrial; Margueron, Claudio [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Escola Politecnica. Dept. de Geologia; Aquino, Thereza C.N. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Escola Politecnica. Inst. de Geociencias

    2004-07-01

    This article discusses the Brazilian Petroleum Agency (ANP) strategy to boost the competitiveness of Brazil in attracting investments to the energy sector, analyzing it both technically and economically. The Campos basin, with its opportunities in heavy oil and deep water exploration, is used as a case study. Previous literature evaluated the economic potential of oil fields under different hypotheses for cost and price structures, reaching the conclusion that the fiscal regime of Brazil in 2000 was internationally competitive and the oil fields under investigation were attractive. This situation no longer applies. Some of the previous hypotheses are reviewed, using the creaming effect, which models both the diminishing success probabilities of drilling and volume levels as a given sedimentary basin approaches its mature stage of exploration. The main conclusion is that a reduction in the government take, lowering the fraction under ANP's control, would foster exploration and production in mature basins. Therefore, a large number of reserves with relatively small VOR's will become feasible, which are currently unattractive, given the hurdle rates observed by the international oil industry. (author)

  13. Electrochemical performance of LiMSnO4 (M=Fe, In) phases with ramsdellite structure as anodes for lithium batteries

    International Nuclear Information System (INIS)

    Satya Kishore, M.V.; Varadaraju, U.V.; Raveau, B.

    2004-01-01

    LiMSnO 4 (M=Fe, In) compounds were synthesized by high temperature solid-state reaction method and the electrochemical studies were carried out vs. lithium metal. Lithium is reversibly intercalated and deintercalated in LiFeSnO 4 with a constant capacity of ∼90mAh/g. In situ X-ray diffraction data show that ramsdellite structure is stable for lithium intercalation and deintercalation in LiFeSnO 4 . Galvanostatic discharge/charge of LiFeSnO 4 in the voltage window 0.05-2.0V shows a reversible capacity of ∼100mAh/g. The observed capacity in LiFeSnO 4 is due to the two processes involving alloying/dealloying of Li 4.4 Sn and formation/decomposition of Li 2 O. In contrast, the new isotypic oxide LiInSnO 4 does not exhibit any lithium intercalation due to the absence of mixed valence for indium. Its reversible capacity is strongly dependent on the voltage window. LiInSnO 4 exhibits severe capacity fading on cycling in the voltage window 0.05-2.0V, but shows a stable capacity of ∼90mAh/g in the voltage range 0.75-2.0V

  14. Quality Evaluation and Chemical Markers Screening of Salvia miltiorrhiza Bge. (Danshen Based on HPLC Fingerprints and HPLC-MSn Coupled with Chemometrics

    Directory of Open Access Journals (Sweden)

    Wenyi Liang

    2017-03-01

    Full Text Available Danshen, the dried root of Salvia miltiorrhiza Bge., is a widely used commercially available herbal drug, and unstable quality of different samples is a current issue. This study focused on a comprehensive and systematic method combining fingerprints and chemical identification with chemometrics for discrimination and quality assessment of Danshen samples. Twenty-five samples were analyzed by HPLC-PAD and HPLC-MSn. Forty-nine components were identified and characteristic fragmentation regularities were summarized for further interpretation of bioactive components. Chemometric analysis was employed to differentiate samples and clarify the quality differences of Danshen including hierarchical cluster analysis, principal component analysis, and partial least squares discriminant analysis. Consistent results were that the samples were divided into three categories which reflected the difference in quality of Danshen samples. By analyzing the reasons for sample classification, it was revealed that the processing method had a more obvious impact on sample classification than the geographical origin, it induced the different content of bioactive compounds and finally lead to different qualities. Cryptotanshinone, trijuganone B, and 15,16-dihydrotanshinone I were screened out as markers to distinguish samples by different processing methods. The developed strategy could provide a reference for evaluation and discrimination of other traditional herbal medicines.

  15. Characterization of Flavonoids and Phenolic Acids in Myrcia bella Cambess. Using FIA-ESI-IT-MSn and HPLC-PAD-ESI-IT-MS Combined with NMR

    Directory of Open Access Journals (Sweden)

    Anne L. Dokkedal

    2013-07-01

    Full Text Available The leaves of Myrcia DC. ex Guill species are used in traditional medicine and are also exploited commercially as herbal drugs for the treatment of diabetes mellitus. The present work aimed to assess the qualitative and quantitative profiles of M. bella hydroalcoholic extract, due to these uses, since the existing legislation in Brazil determines that a standard method must be developed in order to be used for quality control of raw plant materials. The current study identified eleven known flavonoid-O-glycosides and six acylated flavonoid derivatives of myricetin and quercetin, together with two kaempferol glycosides and phenolic acids such as caffeic acid, ethil galate, gallic acid and quinic acid. In total, 24 constituents were characterized, by means of extensive preparative chromatographic analyses, along with MS and NMR techniques. An HPLC-PAD-ESI-IT-MS and FIA-ESI-IT-MSn method were developed for rapid identification of acylated flavonoids, flavonoid-O-glycosides derivatives of myricetin and quercetin and phenolic acids in the hydroalcoholic M. bella leaves extract. The FIA-ESI-IT-MS techinique is a powerful tool for direct and rapid identification of the constituents after isolation and NMR characterization. Thus, it could be used as an initial method for identification of authentic samples concerning quality control of Myrcia spp extracts.

  16. We have "born digital" - now what about "born semantic"?

    Science.gov (United States)

    Leadbetter, Adam; Fredericks, Janet

    2014-05-01

    The phrase "born-digital" refers to those materials which originate in a digital form. In Earth and Space Sciences, this is now very much the norm for data: analogue to digital converters sit on instrument boards and produce a digital record of the observed environment. While much effort has been put in to creating and curating these digital data, there has been little work on using semantic mark up of data from the point of collection - what we term 'born semantic'. In this presentation we report on two efforts to expand this area: Qartod-to-OGC (Q2O) and SenseOCEAN. These projects have taken a common approach to 'born semantic': create or reuse appropriate controlled vocabularies, published to World Wide Web Commission (W3C) standards use standards from the Open Geospatial Consortium's Sensor Web Enablement (SWE) initiative to describe instrument setup, deployment and/or outputs using terms from those controlled vocabularies embed URLs from the controlled vocabularies within the SWE documents in a "Linked Data" conformant approach Q2O developed best practices examples of SensorML descriptions of Original Equipment Manufacturers' metadata (model characteristics, capabilities, manufacturer contact, etc ...) set-up and deployment SensorML files; and data centre process-lineage using registered vocabularies to describe terms (including input, output, processes, parameters, quality control flags) One Q2O use case, the Martha's Vineyard Coastal Observatory ADCP Waves instance, uses SensorML and registered vocabularies to fully describe the process of computing wave parameters from sensed properties, including quality control tests and associated results. The European Commission Framework Programme 7 project SenseOCEAN draws together world leading marine sensor developers to create a highly integrated multifunction and cost-effective in situ marine biogeochemical sensor system. This project will provide a quantum leap in the ability to measure crucial biogeochemical

  17. Surgical experts: born or made?

    Science.gov (United States)

    Sadideen, Hazim; Alvand, Abtin; Saadeddin, Munir; Kneebone, Roger

    2013-01-01

    The concept of surgical expertise and the processes involved in its development are topical, and there is a constant drive to identify reliable measures of expert performance in surgery. This review explores the notion of whether surgical experts are "born" or "made", with reference to educational theory and pertinent literature. Peer-reviewed publications, books, and online resources on surgical education, expertise and training were reviewed. Important themes and aspects of expertise acquisition were identified in order to better understand the concept of a surgical expert. The definition of surgical expertise and several important aspects of its development are highlighted. Innate talent plays an important role, but is insufficient on its own to produce a surgical expert. Multiple theories that explore motor skill acquisition and memory are relevant, and Ericsson's theory of the development of competence followed by deliberate self-practice has been especially influential. Psychomotor and non-technical skills are necessary for progression in the current climate in light of our training curricula; surgical experts are adaptive experts who excel in these. The literature suggests that surgical expertise is reached through practice; surgical experts are made, not born. A deeper understanding of the nature of expert performance and its development will ensure that surgical education training programmes are of the highest possible quality. Surgical educators should aim to develop an expertise-based approach, with expert performance as the benchmark. Copyright © 2013 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

  18. Towards a full reference library of MS(n) spectra. II: A perspective from the library of pesticide spectra extracted from the literature/Internet.

    Science.gov (United States)

    Milman, Boris L; Zhurkovich, Inna K

    2011-12-30

    To gain perspective on building full transferable libraries of MS(n) spectra from their diverse/numerous collections, a new library was built from 1723 MS(>1) spectra (mainly MS² spectra) of 490 pesticides and related compounds. Spectra acquired on different types of tandem instruments in various experimental conditions were extracted from 168 literature articles and Internet sites. Testing of the library was based on searches where 'unknown' and reference spectra originated from different sources (mainly from different laboratories) were cross-compared. The NIST 05 MS² library was added to the reference spectra. The library searches were performed with all the test spectra or were divided into different subsamples containing (a) various numbers of replicate spectra of test compounds or (b) spectra acquired from different instrument types. Thus, the dependence of true/false search (identification) result rates on different factors was explored. The percentage of 1st rank correct identifications (true positives) for the only 'unknown' mass spectrum and two and more reference spectra and matching precursor ion m/z values was 89%. For qualified matches, above the cut-off match factor, that rate decreased to 80%. The corresponding rates based on the best match for two and more 'unknown' and reference spectral replicates were 89-94%. For quadrupole instruments, the rates were even higher: 91-95% (one 'unknown' spectrum) and 90-100% (two and more such spectra). This study shows that MS² spectral libraries generated from the numerous literature/Internet sources are not less efficient for the goal of identification of unknown compounds including pesticides than very common EI-MS¹ libraries and are almost as efficient as the most productive from current MS² spectral databases. Such libraries may be used as individual reference databases or supplements to large experimental spectral collections covering many groups of abundant compounds and different types of tandem

  19. Optimization of biological and instrumental detection of explosives and ignitable liquid residues including canines, SPME/ITMS and GC/MSn

    Science.gov (United States)

    Furton, Kenneth G.; Harper, Ross J.; Perr, Jeannette M.; Almirall, Jose R.

    2003-09-01

    A comprehensive study and comparison is underway using biological detectors and instrumental methods for the rapid detection of ignitable liquid residues (ILR) and high explosives. Headspace solid phase microextraction (SPME) has been demonstrated to be an effective sampling method helping to identify active odor signature chemicals used by detector dogs to locate forensic specimens as well as a rapid pre-concentration technique prior to instrumental detection. Common ignitable liquids and common military and industrial explosives have been studied including trinitrotoluene, tetryl, RDX, HMX, EGDN, PETN and nitroglycerine. This study focuses on identifying volatile odor signature chemicals present, which can be used to enhance the level and reliability of detection of ILR and explosives by canines and instrumental methods. While most instrumental methods currently in use focus on particles and on parent organic compounds, which are often involatile, characteristic volatile organics are generally also present and can be exploited to enhance detection particularly for well-concealed devices. Specific examples include the volatile odor chemicals 2-ethyl-1-hexanol and cyclohexanone, which are readily available in the headspace of the high explosive composition C-4; whereas, the active chemical cyclo-1,3,5-trimethylene-2,4,6-trinitramine (RDX) is not. The analysis and identification of these headspace 'fingerprint' organics is followed by double-blind dog trials of the individual components using certified teams in an attempt to isolate and understand the target compounds to which dogs are sensitive. Studies to compare commonly used training aids with the actual target explosive have also been undertaken to determine their suitability and effectiveness. The optimization of solid phase microextraction (SPME) combined with ion trap mobility spectrometry (ITMS) and gas chromatography/mass spectrometry/mass spectrometry (GC/MSn) is detailed including interface development

  20. Sugar Composition Analysis of Fuzi Polysaccharides by HPLC-MSn and Their Protective Effects on Schwann Cells Exposed to High Glucose

    Directory of Open Access Journals (Sweden)

    Bei-Bei Wang

    2016-11-01

    Full Text Available Fuzi has been used to treat diabetic complications for many years in china. In a previous study, we have shown that Fuzi aqueous extract can attenuate Diabetic peripheral neuropathy (DPN in rats and protect Schwann cells from injury. Thus, the protective effect of Fuzi polysaccharides (FPS on high glucose-induced SCs and the preliminary mechanism were investigated. Firstly, the FPS were obtained and their monose composition was analyzed by the combination of pre-column derivatization and high performance liquid chromatography coupled with electrospray ionization multi-tandem mass spectrometry (HPLC/ESI-MSn. The results witnessed the efficiency of this method and seven monosaccharides were tentatively identified, among which fucose was first reported. Simultaneously, m/z 215 can be considered as diagnostic ions to confirm the number of monosaccharides. Next, high glucose-induced SC model was applied and divided into model group, treated group of FPS, normal and osmotic control group. After treatment for 48 h, the data showed FPS could significantly decrease the intracellular ROS and apoptosis, which were determined by the corresponding fluorescent probes. Then, the expression of oxidative stress-related proteins in SCs were measured by Western blot. Furthermore, the protein tests found that FPS markedly up-regulated superoxide dismutase (SOD, catalase (CAT and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α protein level, but down-regulated NADPH oxidase-1 (Nox1 protein level. Moreover, FPS could also increase AMP-activated protein kinase (AMPK activation significantly. Hence, we preliminary deduced that AMPK-PGC-1α pathway may play an important role in the protective effect of FPS against high glucose-induced cell damage.

  1. A política de educação especial no Brasil (1991-2011: uma análise da produção do GT15 - educação especial da ANPED Special education policy in Brazil (1991-2011: an analysis of the production of anped special education work group

    Directory of Open Access Journals (Sweden)

    Rosalba Maria Cardoso Garcia

    2011-08-01

    Full Text Available o presente artigo aborda a política nacional de Educação Especial, discutindo os principais referentes orientadores e normativos no período 1991-2011. Ao longo desses 20 anos a educação passou por um período de reformas. Na Educação Especial tais reformas alteraram sua definição, redefiniu-se o público a qual se destina esta modalidade e a sua organização no que se refere aos serviços. Procurou-se neste artigo apresentar e analisar as políticas e os programas que constituíram a área no período definido, com especial atenção para o Programa de implementação de salas de recursos, Programa Educação inclusiva: direito à diversidade e Programa Incluir. Foram abordadas a concepção de Educação Especial e os "serviços" correlatos. Na segunda parte do texto desenvolvemos análise da produção do Grupo de Trabalho - GT 15 - Educação Especial da Associação Nacional de Pós-Graduação e Pesquisa em Educação - ANPEd acerca da temática política educacional nos seus vinte anos de existência. Detemo-nos na análise de vinte e nove trabalhos que tiveram como foco central a política educacional. Para efeito da análise, organizamos a produção em oito categorias: implementação, acesso e permanência, formação de professores, currículo, perspectiva inclusiva, estado e educação profissional. O balanço de produção revelou a importância das pesquisas desenvolvidas no país e socializadas no âmbito da GT 15 da ANPEd para a compreensão das políticas de Educação Especial no Brasil no que se refere aos princípios e conceitos fundamentais, proposições e dinâmicas de implementação em redes estaduais e municipais de ensino.This article addresses the national policy for Special Education, discussing the related guidance and regulations in the 1991-2011period. Over this time education has gone through a period of reforms. Such reforms in Special Education changed its definition, redefined the public to which it

  2. A PRODUÇÃO DO CONHECIMENTO SOBRE A POLÍTICA EDUCACIONAL NO BRASIL: UM OLHAR A PARTIR DA ANPED

    Directory of Open Access Journals (Sweden)

    Azevedo Janete Maria Lins de

    2001-01-01

    Full Text Available Este texto contém resultados de uma pesquisa que analisou as características e as tendências da produção do conhecimento sobre a política educacional no Brasil, tomando como base empírica a produção apresentada no Grupo de Trabalho da Anped "Estado e Política Educacional", no período de 1993 a 2000. Tendo como pressupostos que a legitimação dessa produção, assim como as suas tendências predominantes resultam de um embate de tendências/olhares e que os trabalhos traduzem relações efetivas entre os pesquisadores, organizações sociais envolvidas e a realidade analisada, as autoras fazem um resgate histórico da origem e da trajetória deste GT para, em seguida, apresentar -- quantitativa e qualitativamente -- um quadro dos eixos temáticos e subtemáticos que têm prevalecido no período estudado. À luz das análises empreendidas, concluem destacando alcances e limites da institucionalização deste GT e, portanto, do campo do conhecimento focalizado.

  3. Conceptualizing Innovation in Born Global Firms

    DEFF Research Database (Denmark)

    Zijdemans, Erik; Tanev, Stoyan

    2014-01-01

    This research provides insights from recent literature on innovativeness in the environment of born globals. This article will be relevant to researchers interested in born globals and their business environments and, more specifically, the role that innovation plays in their foundation and devel...... of knowledge acquisition, networking capabilities and the lean startup approach in born global innovation. Finally, the article addresses the issue of quantifying and measuring innovativeness....

  4. Non-abelian Born-Infeld revisited

    NARCIS (Netherlands)

    Roo, M. de

    2002-01-01

    We discuss the non-abelian Born-Infeld action, including fermions, as a series in α'. We review recent work establishing the complete result to α'2, and its impact on our earlier attempts to derive the Born-Infeld action using κ-symmetry.

  5. [Climate- and vector-borne diseases

    DEFF Research Database (Denmark)

    Bygbjerg, I.C.; Schioler, K.L.; Konradsen, F.

    2009-01-01

    The predicted changes in climate have raised concerns that vector-borne diseases may emerge or expand in tempered regions. Malaria, leishmaniasis and tick-borne illnesses are discussed in terms of climate change and their endemic potential, especially in Denmark. While climate may play an important...

  6. pp32 (ANP32A expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs.

    Directory of Open Access Journals (Sweden)

    Timothy K Williams

    Full Text Available The expression of protein phosphatase 32 (PP32, ANP32A is low in poorly differentiated pancreatic cancers and is linked to the levels of HuR (ELAV1, a predictive marker for gemcitabine response. In pancreatic cancer cells, exogenous overexpression of pp32 inhibited cell growth, supporting its long-recognized role as a tumor suppressor in pancreatic cancer. In chemotherapeutic sensitivity screening assays, cells overexpressing pp32 were selectively resistant to the nucleoside analogs gemcitabine and cytarabine (ARA-C, but were sensitized to 5-fluorouracil; conversely, silencing pp32 in pancreatic cancer cells enhanced gemcitabine sensitivity. The cytoplasmic levels of pp32 increased after cancer cells are treated with certain stressors, including gemcitabine. pp32 overexpression reduced the association of HuR with the mRNA encoding the gemcitabine-metabolizing enzyme deoxycytidine kinase (dCK, causing a significant reduction in dCK protein levels. Similarly, ectopic pp32 expression caused a reduction in HuR binding of mRNAs encoding tumor-promoting proteins (e.g., VEGF and HuR, while silencing pp32 dramatically enhanced the binding of these mRNA targets. Low pp32 nuclear expression correlated with high-grade tumors and the presence of lymph node metastasis, as compared to patients' tumors with high nuclear pp32 expression. Although pp32 expression levels did not enhance the predictive power of cytoplasmic HuR status, nuclear pp32 levels and cytoplasmic HuR levels associated significantly in patient samples. Thus, we provide novel evidence that the tumor suppressor function of pp32 can be attributed to its ability to disrupt HuR binding to target mRNAs encoding key proteins for cancer cell survival and drug efficacy.

  7. Validation of Born Traveltime Kernels

    Science.gov (United States)

    Baig, A. M.; Dahlen, F. A.; Hung, S.

    2001-12-01

    Most inversions for Earth structure using seismic traveltimes rely on linear ray theory to translate observed traveltime anomalies into seismic velocity anomalies distributed throughout the mantle. However, ray theory is not an appropriate tool to use when velocity anomalies have scale lengths less than the width of the Fresnel zone. In the presence of these structures, we need to turn to a scattering theory in order to adequately describe all of the features observed in the waveform. By coupling the Born approximation to ray theory, the first order dependence of heterogeneity on the cross-correlated traveltimes (described by the Fréchet derivative or, more colourfully, the banana-doughnut kernel) may be determined. To determine for what range of parameters these banana-doughnut kernels outperform linear ray theory, we generate several random media specified by their statistical properties, namely the RMS slowness perturbation and the scale length of the heterogeneity. Acoustic waves are numerically generated from a point source using a 3-D pseudo-spectral wave propagation code. These waves are then recorded at a variety of propagation distances from the source introducing a third parameter to the problem: the number of wavelengths traversed by the wave. When all of the heterogeneity has scale lengths larger than the width of the Fresnel zone, ray theory does as good a job at predicting the cross-correlated traveltime as the banana-doughnut kernels do. Below this limit, wavefront healing becomes a significant effect and ray theory ceases to be effective even though the kernels remain relatively accurate provided the heterogeneity is weak. The study of wave propagation in random media is of a more general interest and we will also show our measurements of the velocity shift and the variance of traveltime compare to various theoretical predictions in a given regime.

  8. Physical Fitness in Young Adults Born Preterm.

    Science.gov (United States)

    Tikanmäki, Marjaana; Tammelin, Tuija; Sipola-Leppänen, Marika; Kaseva, Nina; Matinolli, Hanna-Maria; Miettola, Satu; Eriksson, Johan G; Järvelin, Marjo-Riitta; Vääräsmäki, Marja; Kajantie, Eero

    2016-01-01

    Young adults born preterm have higher levels of cardiometabolic risk factors than their term-born peers. Muscular and cardiorespiratory fitness have important cardiometabolic and other health benefits. We assessed muscular, cardiorespiratory, and self-rated fitness in preterm-born young adults. We studied unimpaired participants of the ESTER (Ennenaikainen syntymä ja aikuisiän terveys [Preterm Birth and Early-Life Programming of Adult Health and Disease]) birth cohort study at age 23.3 (SD: 1.2) years: 139 born early preterm (EPT; Young adults born EPT (-0.8; 95% confidence interval: -1.5 to -0.1; adjusted for gender, age, and source cohort) and LPT (-0.8; -1.4 to -0.3) performed fewer modified push-ups than controls. Handgrip strength was 23.8 (0.9-46.8) N lower in EPT participants. Cardiorespiratory fitness, measured by submaximal step test, was similar. On a self-rated fitness scale (1-5), the EPT adults reported 0.2 (0.0-0.4) lower scores than controls. After adjustment for early-life confounders, the results remained. They attenuated after further adjustment for mediating factors. Young adults born EPT and LPT had lower muscular fitness than controls, which may predispose them to cardiometabolic and other chronic diseases. Adults born EPT also perceived themselves as less fit than controls. Copyright © 2016 by the American Academy of Pediatrics.

  9. [Climate- and vector-borne diseases

    DEFF Research Database (Denmark)

    Bygbjerg, I.C.; Schioler, K.L.; Konradsen, F.

    2009-01-01

    The predicted changes in climate have raised concerns that vector-borne diseases may emerge or expand in tempered regions. Malaria, leishmaniasis and tick-borne illnesses are discussed in terms of climate change and their endemic potential, especially in Denmark. While climate may play an important...... role in disease patterns, it is evident that transmission potential is governed by a complex of factors, including socio-economy, health-care capacity and ecology. In Denmark, malaria and leishmaniasis are unlikely to become public health problems, whereas the potential for tick-borne illnesses may...

  10. Structure-borne noise at hotels

    Science.gov (United States)

    Wilson, George Paul; Jue, Deborah A.

    2002-11-01

    Hotels present a challenging environment for building designers to provide suitable noise and vibration isolation between very incompatible uses. While many are familiar with ways to reduce traditional sources of airborne noise and vibration, structure-borne noise and vibration are often overlooked, often with costly repercussions. Structure-borne noise can be very difficult to pinpoint, and troubleshooting the sources of the vibration can be a tedious process. Therefore, the best approach is to avoid the problem altogether during design, with attention to the building construction, potential vibration sources, building uses and equipment locations. In this paper, the relationship between structure-borne vibration and noise are reviewed, typical vibration sources discussed (e.g., aerobic rooms, laundry rooms, mechanical equipment/building services, and subway rail transit), and key details and design guidance to minimize structure-borne noise provided.

  11. On Born approximation in black hole scattering

    Science.gov (United States)

    Batic, D.; Kelkar, N. G.; Nowakowski, M.

    2011-12-01

    A massless field propagating on spherically symmetric black hole metrics such as the Schwarzschild, Reissner-Nordström and Reissner-Nordström-de Sitter backgrounds is considered. In particular, explicit formulae in terms of transcendental functions for the scattering of massless scalar particles off black holes are derived within a Born approximation. It is shown that the conditions on the existence of the Born integral forbid a straightforward extraction of the quasi normal modes using the Born approximation for the scattering amplitude. Such a method has been used in literature. We suggest a novel, well defined method, to extract the large imaginary part of quasinormal modes via the Coulomb-like phase shift. Furthermore, we compare the numerically evaluated exact scattering amplitude with the Born one to find that the approximation is not very useful for the scattering of massless scalar, electromagnetic as well as gravitational waves from black holes.

  12. Pap Tests and Foreign-Born Women

    Centers for Disease Control (CDC) Podcasts

    Foreign-born women living in the U.S. are less likely to have Pap tests to detect cervical cancer than women born in this country. The problem is worse for women from certain countries or regions. Find out why this is a disturbing trend, who these women are and why they are less likely to get a Pap test, and what CDC is doing about it.

  13. Percursos e tendências da produção científica sobre crianças de 0 a 3 anos na Anped

    Directory of Open Access Journals (Sweden)

    Márcia Buss-Simão

    Full Text Available Resulta de um levantamento dos trabalhos apresentados no GT07: Educação de crianças de 0 a 6 anos, nas reuniões anuais da Associação Nacional de Pós-Graduação e Pesquisa em Educação (Anped, entre os anos de 2003 e 2013, com o objetivo de mapear a produção científica sobre as crianças de zero a três anos de idade. Para a busca dos trabalhos, foram definidas algumas palavras-chave: educação infantil; creche; berçário; crianças pequenas; bebês; zero (0 a três (3. A primeira busca foi realizada nos resumos e nas palavras-chave propostas no próprio artigo, e, quando necessário, recorreu-se ao trabalho completo. A partir dessa busca, foram localizados 23 trabalhos que abordavam a temática, e estes foram lidos na íntegra para categorização e análise. Com base na leitura dos trabalhos, utilizando a estratégia metodológica de análise de conteúdo, foi possível, por meio de método indutivo, agrupá-los em temáticas: "dimensão pedagógica", "perspectivas sociológicas", "políticas para educação infantil" e "história". Destaca-se que no período entre os anos de 2003 a 2013 um total de 175 trabalhos foi apresentado no GT07, dos quais somente 23 trabalhos tiveram como preocupação as crianças de zero a três anos. Embora esse número seja muito inferior ao total, revela-se uma crescente preocupação e prioridade da área em relação à situação da creche e das crianças pequenas.

  14. Foreign-born Peers and Academic Performance.

    Science.gov (United States)

    Conger, Dylan

    2015-04-01

    The academic performance of foreign-born youth in the United States is well studied, yet little is known about whether and how foreign-born students influence their classmates. In this article, I develop a set of expectations regarding the potential consequences of immigrant integration across schools, with a distinction between the effects of sharing schools with immigrants who are designated as English language learners (ELL) and those who are not. I then use administrative data on multiple cohorts of Florida public high school students to estimate the effect of immigrant shares on immigrant and native-born students' academic performance. The identification strategy pays careful attention to the selection problem by estimating the effect of foreign-born peers from deviations in the share foreign-born across cohorts of students attending the same school in different years. The assumption underlying this approach is that students choose schools based on the composition of the entire school, not on the composition of each entering cohort. The results of the analysis, which hold under several robustness checks, indicate that foreign-born peers (both those who are ELL and those who are non-ELL) have no effect on their high school classmates' academic performance.

  15. Políticas para educação de jovens e adultos no Brasil: A Produção da área nos anos de 2011 e 2012 veiculadas na Anped

    Directory of Open Access Journals (Sweden)

    Regina M. B. de Araújo

    2013-01-01

    Full Text Available This article presents an take stock of scientific production on public policies for the education of youth and adults ( EJA presented in the working group “education of the youth and adults”, in the National Association of Graduate Studies and Research in Education ( Anped , in the years 2011 and 2012 . For this study, were consulted all the summaries of the texts submitted to the working group referred, in mentioned period, totaling 32 productions and reading was taken in full of works considered the potential for this research . Some research has been undertaken in order to map the public policies for education of youth and adults in Brazil . The work called state of the art and state of knowledge have been recurrent in various fields of knowledge. Among them include Ventura ( 2008 , Santos and Viana ( 2011 and Araujo and Jardilino ( 2011 . The article presented here is included in this type of research , given its importance and relevance . From the work presented, realize yourself some continuities in what was found in previous research , as well as some changes . Note the reduced number of re - search presented in Anped ,working group 18 , which dealt with the financing of youth and adult education. Also noticed a continuity in increasing the amount of production on federal programs for adult education , especially “PROEJA”.The survey finds a grow - ing interest by the academy understand, analyze and even intervene in this environment, seeking improvements to policies offer adult and youth education in our country.

  16. A hybrid approach based on ANP, ELECTRE and SIMANP metaheuristic method for outsourcing manufacturing procedures according to supply chain risks - Case study: A medical equipment manufacturer company in Iran

    Directory of Open Access Journals (Sweden)

    Hiwa Farughi

    2017-01-01

    Full Text Available Nowadays enterprises should consider seeking to reduce the supply chain risks as a crucial part of their activities in order to improve their competitiveness in the international context. Choosing the suitable strategy in connection with assigning some parts of the production process to outside the organization is a complex multi-criteria decision making problem and it gets more complicated when supply chain risk factors as the factors to select the strategy as well as dependence and the close ties between these criteria also be considered. In this paper, after the identification of risks in the supply chain of a medical equipment manufacturer company, dependence and ties between criteria in line with choosing the best strategy among existing alternatives has been examined in the form of a combined ANP-ELECTRE method. This combined model is of high performance to give a solution to the problem considered in this paper. But given the complex and time consuming nature of the AHP and ELECTRE, in this study a meta-heuristic algorithm is developed called SIMANP that despite the simplicity of computing and high-speed, is good in the terms of precision and efficiency. The results of comparing SIMANP algorithm and the proposed ANP - ELECTRE method are presented at the end.

  17. Wavefield separation by energy norm Born scattering

    KAUST Repository

    Sun, Bingbing

    2017-08-17

    In Reflection Based Waveform Inversion, the gradient is computed by cross-correlating the direct and Born scattered wavefield with their adjoints applied to the data residuals. In this case, the transmitted part of the Born scattered wavefield produces high wavenumber artifacts, which would harm the convergence of the inversion process. We propose an efficient Energy Norm Born Scattering (ENBS) to attenuate the transmission components of the Born modeling, and allow it to produce only reflections. ENBS is derived from the adjoint of the Energy Norm (inverse scattering) imaging condition and in order to get deeper insights of how this method works, we show analytically that given an image, in which reflectivity is represented by a Dirac delta function, ENBS attenuates transmission energy perfectly. We use numerical examples to demonstrate that ENBS works in both the time and the frequency domain. We also show that in reflection waveform inversion (RWI) the wave path constructed by ENBS would be cleaner and free of high wavenumber artifacts associated with conventional Born scattering.

  18. Wavefield separation by energy norm Born scattering

    KAUST Repository

    Sun, Bingbing; Alkhalifah, Tariq Ali

    2017-01-01

    In Reflection Based Waveform Inversion, the gradient is computed by cross-correlating the direct and Born scattered wavefield with their adjoints applied to the data residuals. In this case, the transmitted part of the Born scattered wavefield produces high wavenumber artifacts, which would harm the convergence of the inversion process. We propose an efficient Energy Norm Born Scattering (ENBS) to attenuate the transmission components of the Born modeling, and allow it to produce only reflections. ENBS is derived from the adjoint of the Energy Norm (inverse scattering) imaging condition and in order to get deeper insights of how this method works, we show analytically that given an image, in which reflectivity is represented by a Dirac delta function, ENBS attenuates transmission energy perfectly. We use numerical examples to demonstrate that ENBS works in both the time and the frequency domain. We also show that in reflection waveform inversion (RWI) the wave path constructed by ENBS would be cleaner and free of high wavenumber artifacts associated with conventional Born scattering.

  19. Tornado-borne missile speeds. Final report

    International Nuclear Information System (INIS)

    Simiu, E.; Cordes, M.

    1976-04-01

    An investigation of the question of tornado-borne missile speeds was carried out, with a view to identify pertinent areas of uncertainty and to estimate credible tornado-borne missile speeds - within the limitations inherent in the present state of the art. The investigation consists of two parts: (1) a study in which a rational model for the missile motion is proposed, and numerical experiments are carried out corresponding to various assumptions on the initial conditions of the missile motion, the structure of the tornado flow, and the aerodynamic properties of the missile; (2) a theoretical and experimental study of tornado-borne missile aerodynamics, conducted by Colorado State Univ. (CSU) to be covered in a separate report by CSU. In the present report, the factors affecting missile motion and their influence upon such motion are examined

  20. Dual symmetry in Born-Infeld theory

    International Nuclear Information System (INIS)

    Khademi, S; Ayoubi, A

    2008-01-01

    Born-Infeld theory is a non-linear formalism which has many applications in string and electromagnetic theories. Although, the existence of magnetic monopoles and dyons are suggested by Born-Infeld theory, but this theory is not invariant under the dual transformations. In this theory electric fields for point charged particles are not singular at origin (r = 0), but magnetic fields and vector potentials are still singular. In this paper we show that the vanishing of dual symmetry is responsible for these singularities. Furthermore, we present the dual symmetric Born-Infeld theory, by a symmetric definition of electromagnetic fields in terms of new scalar and vector potentials, as well as the ordinary ones. All singularities of vector potential and magnetic field are removed as an immediate consequence of this symmetry.

  1. On transparent potentials: a Born approximation study

    International Nuclear Information System (INIS)

    Coudray, C.

    1980-01-01

    In the frame of the scattering inverse problem at fixed energy, a class of potentials transparent in Born approximation is obtained. All these potentials are spherically symmetric and are oscillating functions of the reduced radial variable. Amongst them, the Born approximation of the transparent potential of the Newton-Sabatier method is found. In the same class, quasi-transparent potentials are exhibited. Very general features of potentials transparent in Born approximation are then stated. And bounds are given for the exact scattering amplitudes corresponding to most of the potentials previously exhibited. These bounds, obtained at fixed energy, and for large values of the angular momentum, are found to be independent on the energy

  2. [Conflicts and vector-borne diseases

    DEFF Research Database (Denmark)

    Bygbjerg, Ib Christian

    2010-01-01

    Based on literature and personal experiences, vector-borne diseases and conflicts are reviewed. Simple rapid diagnostic tests for three important parasitoses are available. Resort is often made to case definitions and to presumptive treatment. Resistance is an emerging problem. Vaccines are still...... not available for most diseases. Promising preventive methods, including long-lasting impregnated bed-nets and tents, are available. War has been an impetus for disclosing life-cycles of vector-borne diseases and for control methods; peace, reconciliation and poverty reduction are required to achieve lasting...

  3. Pap Tests and Foreign-Born Women

    Centers for Disease Control (CDC) Podcasts

    2007-11-26

    Foreign-born women living in the U.S. are less likely to have Pap tests to detect cervical cancer than women born in this country. The problem is worse for women from certain countries or regions. Find out why this is a disturbing trend, who these women are and why they are less likely to get a Pap test, and what CDC is doing about it.  Created: 11/26/2007 by National Breast and Cervical Cancer Early Detection Program.   Date Released: 12/7/2007.

  4. Probabilities from entanglement, Born's rule from envariance

    International Nuclear Information System (INIS)

    Zurek, W.

    2005-01-01

    Full text: I shall discuss consequences of envariance (environment - assisted invariance) symmetry exhibited by entangled quantum states. I shall focus on the implications of envariance for the understanding of the origins and nature of ignorance, and, hence, for the origin of probabilities in physics. While the derivation of the Born's rule for probabilities (pk IykI2) is the principal accomplishment of this research, I shall explore the possibility that several other symptoms of the quantum - classical transition that are a consequence of decoherence can be justified directly by envariance -- i.e., without invoking Born's rule. (author)

  5. Born's reciprocity principle in stochastic phase space

    International Nuclear Information System (INIS)

    Prugovecki, E.

    1981-01-01

    It is shown that the application of Born's reciprocity principle to relativistic quantum mechanics in stochastic phase space (by the requirement that the proper wave functions of extended particles satisfy the Born-Lande as well as the Klein-Gordon equation) leads to the unique determination of these functions for any given value of their rms radius. The resulting particle propagators display not only Lorentz but also reciprocal invariance. This feature remains true even in the case of mass-zero particles, such as photons, when their localization is achieved by means of extended test particles whose proper wave functions obey the reciprocity principle. (author)

  6. [Conflicts and vector-borne diseases

    DEFF Research Database (Denmark)

    Bygbjerg, Ib Christian

    2010-01-01

    Based on literature and personal experiences, vector-borne diseases and conflicts are reviewed. Simple rapid diagnostic tests for three important parasitoses are available. Resort is often made to case definitions and to presumptive treatment. Resistance is an emerging problem. Vaccines are still...

  7. Scientific Discoveries the Year I Was Born

    Science.gov (United States)

    Cherif, Abour

    2012-01-01

    The author has successfully used a learning activity titled "The Year I Was Born" to motivate students to conduct historical research and present key scientific discoveries from their birth year. The activity promotes writing, helps students enhance their scientific literacy, and also improves their attitude toward the learning of science. As one…

  8. Testing Born-Infeld Electrodynamics in Waveguides

    International Nuclear Information System (INIS)

    Ferraro, Rafael

    2007-01-01

    Waveguides can be employed to test nonlinear effects in electrodynamics. We solve Born-Infeld equations for TE waves in a rectangular waveguide. We show that the energy velocity acquires a dependence on the amplitude, and harmonic components appear as a consequence of the nonlinear behavior

  9. Born with Protection against Whooping Cough

    Centers for Disease Control (CDC) Podcasts

    This podcast provides information about whooping cough, a disease that can be deadly for babies, and CDC’s recommendation that all women receive the Tdap vaccine during the third trimester of every pregnancy so their babies can be born with protection from this serious disease.

  10. Joint Laxity in Preschool Children Born Preterm.

    Science.gov (United States)

    Romeo, Domenico M; Velli, Chiara; Lucibello, Simona; Ferrantini, Gloria; Leo, Giuseppina; Brogna, Claudia; Cota, Francesco; Ricci, Daniela; Gallini, Francesca; Romagnoli, Costantino; Vento, Giovanni; Mercuri, Eugenio

    2018-06-01

    To evaluate the prevalence of joint laxity in children born preterm assessed in the first 2 years, the relationship between joint laxity and motor performance at preschool age, and possible changes over time in a subgroup of children followed longitudinally. The revised scale of Beighton Score was used to evaluate joint laxity in a population of 132 preschool children born preterm between 24 and 32 weeks of gestational age. All were assessed for joint laxity between 12 and 24 months of age. Children also performed the Movement Assessment Battery for Children-Second Edition between the age of 3 years and 6 months and 4 years; the age at onset of independent walking also was recorded. The total Beighton Score ranged between 0 and 8. Twenty percent of the cohort showed joint laxity. No differences related to sex or gestational age were observed. Children born preterm with joint laxity achieved later independent walking and achieved lower scores on Movement Assessment Battery for Children-Second Edition than those without joint laxity. In 76 children born preterm, an assessment for joint laxity was repeated once between 25 and 36 months and again after >36 months. No statistically significant difference was observed between the 3 assessments. The Beighton Score can be used to assess generalized joint laxity in children born preterm. As the presence of joint laxity influenced motor competences, the possibility to early identify these infants in the first 2 years is of interest to benefit from early intervention and potentially improve gross motor skills and coordination. Copyright © 2018 Elsevier Inc. All rights reserved.

  11. Efectividad de la logística del transporte aéreo de mercancías: Una aproximación multicriterio basada en el Proceso Analítico Sistémico (ANP)

    OpenAIRE

    Ponce Pérez, David; Larrodé Pellicer, Emilio; Moreno Jiménez, José María

    2012-01-01

    El objetivo principal de la presente Tesis Doctoral es crear y desarrollar un modelo de análisis que permita medir la alineación de los objetivos estratégicos del transporte aéreo de mercancías en la Situación Actual del sistema con dichos objetivos estratégicos en la Situación Ideal. Para ello, dicho modelo de análisis se basa en el apoyo metodológico que se obtiene de la técnica de análisis multicriterio Proceso de Análisis Sistémico (Anlytic Network Porcess, ANP) de T. Saaty (1996). Esta t...

  12. Differences in the self-reported racism experiences of US-born and foreign-born Black pregnant women

    OpenAIRE

    Dominguez, Tyan Parker; Strong, Emily Ficklin; Krieger, Nancy; Gillman, Matthew W.; Rich-Edwards, Janet W.

    2009-01-01

    Differential exposure to minority status stressors may help explain differences in United States (US)-born and foreign-born Black women’s birth outcomes. We explored self-reports of racism recorded in a survey of 185 US-born and 114 foreign-born Black pregnant women enrolled in Project Viva, a prospective cohort study of pregnant women in Boston, Massachusetts, USA. Self-reported prevalence of personal racism and group racism was significantly higher among US-born than foreign-born Black preg...

  13. Approximated solutions to Born-Infeld dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Ferraro, Rafael [Instituto de Astronomía y Física del Espacio (IAFE, CONICET-UBA),Casilla de Correo 67, Sucursal 28, 1428 Buenos Aires (Argentina); Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires,Ciudad Universitaria, Pabellón I, 1428 Buenos Aires (Argentina); Nigro, Mauro [Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires,Ciudad Universitaria, Pabellón I, 1428 Buenos Aires (Argentina)

    2016-02-01

    The Born-Infeld equation in the plane is usefully captured in complex language. The general exact solution can be written as a combination of holomorphic and anti-holomorphic functions. However, this solution only expresses the potential in an implicit way. We rework the formulation to obtain the complex potential in an explicit way, by means of a perturbative procedure. We take care of the secular behavior common to this kind of approach, by resorting to a symmetry the equation has at the considered order of approximation. We apply the method to build approximated solutions to Born-Infeld electrodynamics. We solve for BI electromagnetic waves traveling in opposite directions. We study the propagation at interfaces, with the aim of searching for effects susceptible to experimental detection. In particular, we show that a reflected wave is produced when a wave is incident on a semi-space containing a magnetostatic field.

  14. Scalar geons in Born-Infeld gravity

    Energy Technology Data Exchange (ETDEWEB)

    Afonso, V.I. [Unidade Acadêmica de Física, Universidade Federal de Campina Grande, 58109-970 Campina Grande, PB (Brazil); Olmo, Gonzalo J. [Departamento de Física Teórica and IFIC, Centro Mixto Universidad de Valencia—CSIC, Universidad de Valencia, Burjassot-46100, Valencia (Spain); Rubiera-Garcia, D., E-mail: viafonso@df.ufcg.edu.br, E-mail: gonzalo.olmo@uv.es, E-mail: drgarcia@fc.ul.pt [Instituto de Astrofísica e Ciências do Espaço, Faculdade de Ciências da Universidade de Lisboa, Edifício C8, Campo Grande, P-1749-016 Lisbon (Portugal)

    2017-08-01

    The existence of static, spherically symmetric, self-gravitating scalar field solutions in the context of Born-Infeld gravity is explored. Upon a combination of analytical approximations and numerical methods, the equations for a free scalar field (without a potential term) are solved, verifying that the solutions recover the predictions of General Relativity far from the center but finding important new effects in the central regions. We find two classes of objects depending on the ratio between the Schwarzschild radius and a length scale associated to the Born-Infeld theory: massive solutions have a wormhole structure, with their throat at r ≈ 2 M , while for the lighter configurations the topology is Euclidean. The total energy density of these solutions exhibits a solitonic profile with a maximum peaked away from the center, and located at the throat whenever a wormhole exists. The geodesic structure and curvature invariants are analyzed for the various configurations considered.

  15. Approximated solutions to Born-Infeld dynamics

    International Nuclear Information System (INIS)

    Ferraro, Rafael; Nigro, Mauro

    2016-01-01

    The Born-Infeld equation in the plane is usefully captured in complex language. The general exact solution can be written as a combination of holomorphic and anti-holomorphic functions. However, this solution only expresses the potential in an implicit way. We rework the formulation to obtain the complex potential in an explicit way, by means of a perturbative procedure. We take care of the secular behavior common to this kind of approach, by resorting to a symmetry the equation has at the considered order of approximation. We apply the method to build approximated solutions to Born-Infeld electrodynamics. We solve for BI electromagnetic waves traveling in opposite directions. We study the propagation at interfaces, with the aim of searching for effects susceptible to experimental detection. In particular, we show that a reflected wave is produced when a wave is incident on a semi-space containing a magnetostatic field.

  16. VECTOR BORNE TRANSMISSIBLE ZOONOSES IN MONTENEGRO

    Directory of Open Access Journals (Sweden)

    Gordana Mijovic

    2012-02-01

    Full Text Available Vector borne transmissible zoonoses are becoming more and more important in the group of emerging and re-emerging infections. We present the characteristics and actuality of this group of infectious diseases in Montenegro for the period 1998 - 2011. In examinations, standard epidemiological, clinical, serological, pathohistological diagnostic methods are employed. Natural conditions in Montenegro make it an important endemic area for more vector borne transmissible zoonoses. The changes of ecological characteristics, the vectors and infective agents, present the accidence for expansion and increasing importance of these infections in national pathology. According to the fact that it is an international port of nautical, continental and air traffic, Montenegro has responsibility for control and management of diseases belonging to the group of the travel and tropical diseases.

  17. On generalized Born-Infeld electrodynamics

    International Nuclear Information System (INIS)

    Kruglov, S I

    2010-01-01

    The generalized Born-Infeld electrodynamics with two parameters is investigated. In this model the propagation of a linearly polarized laser beam in the external transverse magnetic field is considered. It was shown that there is the effect of vacuum birefringence, and we evaluate induced ellipticity. The upper bounds on the combination of parameters introduced from the experimental data of BRST and PVLAS Collaborations were obtained. When two parameters are equal to each other, we arrive at Born-Infeld electrodynamics and the effect of vacuum birefringence vanishes. We find the canonical and symmetrical Belinfante energy-momentum tensors. The trace of the energy-momentum tensor is not zero and the dilatation symmetry is broken. The four-divergence of the dilatation current is equal to the trace of the Belinfante energy-momentum tensor and is proportional to the parameter (with the dimension of the field strength) of the model. The dual symmetry is also broken in the model considered.

  18. Generalized Born Models of Macromolecular Solvation Effects

    Science.gov (United States)

    Bashford, Donald; Case, David A.

    2000-10-01

    It would often be useful in computer simulations to use a simple description of solvation effects, instead of explicitly representing the individual solvent molecules. Continuum dielectric models often work well in describing the thermodynamic aspects of aqueous solvation, and approximations to such models that avoid the need to solve the Poisson equation are attractive because of their computational efficiency. Here we give an overview of one such approximation, the generalized Born model, which is simple and fast enough to be used for molecular dynamics simulations of proteins and nucleic acids. We discuss its strengths and weaknesses, both for its fidelity to the underlying continuum model and for its ability to replace explicit consideration of solvent molecules in macromolecular simulations. We focus particularly on versions of the generalized Born model that have a pair-wise analytical form, and therefore fit most naturally into conventional molecular mechanics calculations.

  19. Geometrical dynamics of Born-Infeld objects

    Energy Technology Data Exchange (ETDEWEB)

    Cordero, Ruben [Departamento de Fisica, Escuela Superior de Fisica y Matematicas del I.P.N., Unidad Adolfo Lopez Mateos, Edificio 9, 07738 Mexico, D.F. (Mexico); Molgado, Alberto [Facultad de Ciencias, Universidad de Colima, Bernal DIaz del Castillo 340, Col. Villas San Sebastian, Colima (Mexico); Rojas, Efrain [Facultad de Fisica e Inteligencia Artificial, Universidad Veracruzana, 91000 Xalapa, Veracruz (Mexico)

    2007-03-21

    We present a geometrically inspired study of the dynamics of Dp-branes. We focus on the usual non-polynomial Dirac-Born-Infeld action for the worldvolume swept out by the brane in its evolution in general background spacetimes. We emphasize the form of the resulting equations of motion which are quite simple and resemble Newton's second law, complemented with a conservation law for a worldvolume bicurrent. We take a closer look at the classical Hamiltonian analysis which is supported by the ADM framework of general relativity. The constraints and their algebra are identified as well as the geometrical role they play in phase space. In order to illustrate our results, we review the dynamics of a D1-brane immersed in a AdS{sub 3} x S{sup 3} background spacetime. We exhibit the mechanical properties of Born-Infeld objects paving the way to a consistent quantum formulation.

  20. Geometrical dynamics of Born-Infeld objects

    International Nuclear Information System (INIS)

    Cordero, Ruben; Molgado, Alberto; Rojas, Efrain

    2007-01-01

    We present a geometrically inspired study of the dynamics of Dp-branes. We focus on the usual non-polynomial Dirac-Born-Infeld action for the worldvolume swept out by the brane in its evolution in general background spacetimes. We emphasize the form of the resulting equations of motion which are quite simple and resemble Newton's second law, complemented with a conservation law for a worldvolume bicurrent. We take a closer look at the classical Hamiltonian analysis which is supported by the ADM framework of general relativity. The constraints and their algebra are identified as well as the geometrical role they play in phase space. In order to illustrate our results, we review the dynamics of a D1-brane immersed in a AdS 3 x S 3 background spacetime. We exhibit the mechanical properties of Born-Infeld objects paving the way to a consistent quantum formulation

  1. serological detection of seed borne viruses in cowpea regenerated

    African Journals Online (AJOL)

    Administrator

    out to detect the presence of seed borne viruses in fourteen cowpea accessions ... were serologically indexed to detect any seed-borne viruses after acclimatisation to screen house conditions. The .... showed external virus-like symptoms were.

  2. Born-Infeld gravity in Weitzenboeck spacetime

    International Nuclear Information System (INIS)

    Ferraro, Rafael; Fiorini, Franco

    2008-01-01

    Using the teleparallel equivalent of general relativity formulated in Weitzenboeck spacetime, we thoroughly explore a kind of Born-Infeld regular gravity leading to second order field equations for the vielbein components. We explicitly solve the equations of motion for two examples: the extended Banados-Teitelboim-Zanelli black hole, which exists even if the cosmological constant is positive, and a cosmological model with matter, where the scale factor is well behaved, thus giving a singularity-free solution.

  3. Mosquito-borne viruses in Europe

    Czech Academy of Sciences Publication Activity Database

    Hubálek, Zdeněk

    2008-01-01

    Roč. 103, Suppl. 1 (2008), S29-S43 ISSN 0932-0113. [Vector-borne diseases: impact of climate change on vectors and rodent reservoirs. Berlin, 27.09.2007-28.09.2007] R&D Projects: GA AV ČR IAA600930611 Institutional research plan: CEZ:AV0Z60930519 Keywords : moboviruses * epidemiology Subject RIV: EE - Microbiology, Virology Impact factor: 1.473, year: 2008

  4. Leak detection using structure-borne noise

    Science.gov (United States)

    Holland, Stephen D. (Inventor); Chimenti, Dale E. (Inventor); Roberts, Ronald A. (Inventor)

    2010-01-01

    A method for detection and location of air leaks in a pressure vessel, such as a spacecraft, includes sensing structure-borne ultrasound waveforms associated with turbulence caused by a leak from a plurality of sensors and cross correlating the waveforms to determine existence and location of the leak. Different configurations of sensors and corresponding methods can be used. An apparatus for performing the methods is also provided.

  5. Dynamics of Born-Infeld membranes

    Energy Technology Data Exchange (ETDEWEB)

    Cordero, R [Departamento de Fisica, Escuela Superior de Fisica y Matematicas del I.P.N., Unidad Adolfo Lopez Mateos, Edificio 9, 07738 Mexico, D.F. (Mexico); Molgado, A [Facultad de Ciencias, Universidad de Colima, Bernal DIaz del Castillo 340, Col. Villas San Sebastian, Colima (Mexico); Rojas, E [Facultad de Fisica e Inteligencia Artificial, Universidad Veracruzana, 91000 Xalapa, Veracruz (Mexico)

    2007-11-15

    We present a geometrical inspired study of the dynamics of Dp-branes. We focus on the usual nonpolynomial Dirac-Born-Infeld action for the worldvolume swept out by the brane in its evolution in general background spacetimes. We emphasize the form of the resulting equations of motion which are quite simple and resemble Newton's second law, complemented with a conservation law for a worldvolume bicurrent.

  6. Dynamics of Born-Infeld membranes

    International Nuclear Information System (INIS)

    Cordero, R; Molgado, A; Rojas, E

    2007-01-01

    We present a geometrical inspired study of the dynamics of Dp-branes. We focus on the usual nonpolynomial Dirac-Born-Infeld action for the worldvolume swept out by the brane in its evolution in general background spacetimes. We emphasize the form of the resulting equations of motion which are quite simple and resemble Newton's second law, complemented with a conservation law for a worldvolume bicurrent

  7. Spectrophotometric determination of substrate-borne polyacrylamide.

    Science.gov (United States)

    Lu, Jianhang; Wu, Laosheng

    2002-08-28

    Polyacrylamides (PAMs) have wide application in many industries and in agriculture. Scientific research and industrial applications manifested a need for a method that can quantify substrate-borne PAM. The N-bromination method (a PAM analytical technique based on N-bromination of amide groups and spectrophotometric determination of the formed starch-triiodide complex), which was originally developed for determining PAM in aqueous solutions, was modified to quantify substrate-borne PAM. In the modified method, the quantity of substrate-borne PAM was converted to a concentration of starch-triiodide complex in aqueous solution that was then measured by spectrophotometry. The method sensitivity varied with substrates due to sorption of reagents and reaction intermediates on the substrates. Therefore, separate calibration for each substrate was required. Results from PAM samples in sand, cellulose, organic matter burnt soils, and clay minerals showed that this method had good accuracy and reproducibility. The PAM recoveries ranged from 95.8% to 103.7%, and the relative standard deviations (n = 4) were application and facilitating PAM-related research.

  8. Zoonotic aspects of vector-borne infections.

    Science.gov (United States)

    Failloux, A-B; Moutailler, S

    2015-04-01

    Vector-borne diseases are principally zoonotic diseases transmitted to humans by animals. Pathogens such as bacteria, parasites and viruses are primarily maintained within an enzootic cycle between populations of non-human primates or other mammals and largely non-anthropophilic vectors. This 'wild' cycle sometimes spills over in the form of occasional infections of humans and domestic animals. Lifestyle changes, incursions by humans into natural habitats and changes in agropastoral practices create opportunities that make the borders between wildlife and humans more permeable. Some vector-borne diseases have dispensed with the need for amplification in wild or domestic animals and they can now be directly transmitted to humans. This applies to some viruses (dengue and chikungunya) that have caused major epidemics. Bacteria of the genus Bartonella have reduced their transmission cycle to the minimum, with humans acting as reservoir, amplifier and disseminator. The design of control strategies for vector-borne diseases should be guided by research into emergence mechanisms in order to understand how a wild cycle can produce a pathogen that goes on to cause devastating urban epidemics.

  9. Anion photoelectron spectroscopy of germanium and tin clusters containing a transition- or lanthanide-metal atom; MGe(n)- (n = 8-20) and MSn(n)- (n = 15-17) (M = Sc-V, Y-Nb, and Lu-Ta).

    Science.gov (United States)

    Atobe, Junko; Koyasu, Kiichirou; Furuse, Shunsuke; Nakajima, Atsushi

    2012-07-14

    The electronic properties of germanium and tin clusters containing a transition- or lanthanide-metal atom from group 3, 4, or 5, MGe(n) (M = Sc, Ti, V, Y, Zr, Nb, Lu, Hf, and Ta) and MSn(n) (M = Sc, Ti, Y. Zr, and Hf), were investigated by anion photoelectron spectroscopy at 213 nm. In the case of the group 3 elements Sc, Y, and Lu, the threshold energy of electron detachment of MGe(n)(-) exhibits local maxima at n = 10 and 16, while in the case of the group 4 elements Ti, Zr, and Hf, it exhibits a local minimum only at n = 16, associated with the presence of a small bump in the spectrum. A similar behavior is observed for MSn(n)(-) around n = 16, and these electronic characteristics of MGe(n) and MSn(n) are closely related to those of MSi(n). Compared to MSi(n), however, the larger cavity size of a Ge(n) cage allows metal atom encapsulation at a smaller size n. A cooperative effect between the electronic and geometric structures of clusters with a large cavity of Ge(16) or Sn(16) is discussed together with the results of experiments that probe their geometric stability via their reactivity to H(2)O adsorption.

  10. The wild life of tick-borne pathogens

    OpenAIRE

    Hofmeester, Tim R.

    2016-01-01

    Diseases that are transmitted by arthropod vectors from animal hosts to humans – so called zoonotic vector-borne diseases – have increased in incidence in the last decades. In North America and Europe, tick-borne pathogens cause the majority of vector-borne diseases, including Lyme borreliosis and tick-borne encephalitis. The pathogens causing these diseases are transmitted by tick species within the Ixodes ricinus complex. These are generalist ticks that have a multi-year lifecycle with thre...

  11. The wild life of tick-borne pathogens

    NARCIS (Netherlands)

    Hofmeester, Tim R.

    2016-01-01

    Diseases that are transmitted by arthropod vectors from animal hosts to humans – so called zoonotic vector-borne diseases – have increased in incidence in the last decades. In North America and Europe, tick-borne pathogens cause the majority of vector-borne diseases, including Lyme borreliosis

  12. MijnBorne2030: evaluatie van een democratisch experiment

    NARCIS (Netherlands)

    Denters, Sebastianus A.H.; Klok, Pieter J.

    2015-01-01

    This article is about one of the experiments in local democratic renewal: MyBorne2030 (in Dutch ‘MijnBorne2030’). The aim of the project was to develop a communal vision for Borne (a relatively small suburban municipality of 20.000 inhabitants in the East of the Netherlands) for the year 2030. A

  13. Prostate Cancer Prognostic Factors Among Asian Patients Born in the US Compared to Those Born Abroad.

    Science.gov (United States)

    Xu, Junjun; Goodman, Michael; Jemal, Ahemdin; Fedewa, Stacey A

    2015-06-01

    US surveillance data indicate that incidence of prostate cancer differs by place of birth among Asian men. However, it is less clear if the prognostic factors for prostate cancer also differ by place of birth. The study included 7,824 Asian prostate cancer patients diagnosed between 2004 and 2009 and reported to the Surveillance Epidemiology and End Results (SEER) program. Logistic regression models were used to evaluate the relation of place of birth (foreign born vs. US born) to three outcomes: prostate specific antigen (PSA) level, Gleason score, and T classification, adjusting for age, marital status, Rural-Urban Continuum Code, and SEER registry. All outcome variables were binary using different cutoffs: ≥ 4, ≥ 10 and ≥ 20 ng/ml for PSA; ≥ 7 and ≥ 8 for Gleason score; and ≥ T2 and ≥ T3 for T classification. Elevated PSA was more common among foreign born Asian men regardless of the cut point used. In the analysis comparing foreign born versus US born patients by ethnic group, the association with PSA was most pronounced at cut point of ≥ 20 ng/ml for Chinese men (OR 1.68, 95% CI 1.02-2.75), and at cut point of ≥ 4 ng/ml for Japanese men (OR 2.73, 95% CI 1.20-6.21). A statistically significant association with Gleason score was only found for Japanese men and only for the cutoff ≥ 7 (OR 1.71, 95% CI 1.12-2.61). There was no difference in clinical T classification between foreign-born and US-born Asian men. Inclusion of cases with missing place of birth or restriction of data to those who underwent radical prostatectomy did not substantially change the results. The data suggest that foreign-born Asian prostate cancer patients may have moderately elevated PSA levels at diagnosis compared with their US born counterparts. For the other prognostic markers, the associations were less consistent and did not form a discernible pattern.

  14. One-stage tooth-borne distraction versus two stage bone-borne distraction in surgically assisted maxillary expansion (SARME).

    Science.gov (United States)

    Seeberger, Robin; Abe-Nickler, Dorothee; Hoffmann, Jürgen; Kunzmann, Kevin; Zingler, Sebastian

    2015-12-01

    To evaluate and compare the effects of tooth-borne and bone-borne distraction devices in surgically assisted maxillary expansion (SARME) on dental and skeletal structures. A sample of 33 skeletally mature patients with transverse maxillary deficiencies was examined with cone beam computed tomography (CBCT) before and 3 months after surgery. Fourteen patients were treated with tooth-borne devices and 19 patients with bone-borne devices. Dental crown expansion in the first premolars did not differ significantly between the two groups, and median expansion was 5.55 mm (interquartile range [IQR] 5.23) in the tooth-borne device group and 4.6 mm (IQR 3.4) in the bone-borne device group. In the first molars, crown expansion and lateral tipping were significantly greater in the tooth-borne device group (P ≤ .02). The median skeletal nasal isthmus increase was significantly more in the bone-borne device group at 3.0 mm than in the tooth-borne device group at 0.98 mm (P ≤ .02). Both tooth-borne and bone-borne devices are effective treatment modalities to correct maxillary transverse deficiencies. Bone-borne devices produced greater widening of the skeletal nasal floor and fewer dental side effects in the first molars. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. OUTCOMES OF TICK-BORNE ENCEPHALITIS IN THE TOMSK REGION

    Directory of Open Access Journals (Sweden)

    T. S. Pinegina

    2013-01-01

    Full Text Available The results of the study outcomes of tick-borne encephalitis in adults in the Tomsk Region. Patients conducted a comprehensive clinical and laboratory examination. Revealed the prevalence of autonomic disorders in individuals who have had at different periods of tick-borne encephalitis, which is regarded as the effects of tick-borne infection. Residual effects of tick-borne encephalitis occurs mainly in the form of light paresis after suffering a focal forms. Among the chronic (progredient forms of tick-borne encephalitis often formed hyperkinetic options. Most of the study revealed the presence of precipitating factors that could have an influence on the outcome. Fundamental diffe rences in all-clinical and immunological analyses at patients with various outcomes of tick-borne encephalitis it wasn't noted. KEY WORDS: tick-borne encephalitis, Tomsk Region, the outcomes.

  16. Born too soon: preterm birth matters.

    Science.gov (United States)

    Howson, Christopher P; Kinney, Mary V; McDougall, Lori; Lawn, Joy E

    2013-01-01

    Urgent action is needed to address preterm birth given that the fi rst country-level estimates show that globally 15 million babies are born too soon and rates are increasing in most countries with reliable time trend data. As the fi rst in a supplement entitled “Born Too Soon”, this paper focuses on the global policy context. Preterm birth is critical for progress on Millennium Development Goal 4 (MDG) for child survival by 2015 and beyond, and gives added value to maternal health (MDG 5) investments also linking to non-communicable diseases. For preterm babies who survive, the additional burden of prematurity-related disability may aff ect families and health systems. Prematurity is an explicit priority in many high-income settings; however, more attention is needed especially in low- and middle-income countries where the invisibility of preterm birth as well as its myths and misconceptions have slowed action on prevention and care. Recent global attention to preterm birth hit a tipping point in 2012, with the May 2 publication of Born Too Soon: The Global Action Report on Preterm Birth and with the 2nd annual World Prematurity Day on November 17 which mobilised the actions of partners in many countries to address preterm birth and newborn health. Interventions to strengthen preterm birth prevention and care span the continuum of care for reproductive, maternal, newborn and child health. Both prevention of preterm birth and implementation of care of premature babies require more research, as well as more policy attention and programmatic investment.

  17. Convergence of the Distorted Wave Born series

    International Nuclear Information System (INIS)

    MacMillan, D.S.

    1981-01-01

    The aim of this thesis is to begin to understand the idea of reaction mechanisms in nonrelativistic scattering systems. If we have a complete reaction theory of a particular scattering system, then we claim that the theory itself must contain information about important reaction mechanisms in the system. This information can be used to decide what reaction mechanisms should be included in an approximate calculation. To investigate this claim, we studied several solvable models. The primary concept employed in studying our models is the convergence of the multistep series generated by iterating the corresponding scattering integral equation. We known that the eigenvalues of the kernel of the Lippmann-Schwinger equation for potential scattering determine the rate of convergence of the Born series. The Born series will converge only if these eigenvalues all life within the unit circle. We extend these results to a study of the distorted wave Born series for inelastic scattering. The convergence criterion tells us when approximations are valid. We learn how the convergence of the distorted wave series depends upon energy, coupling constants, angular momentum, and angular momentum transfer. In one of our models, we look at several possible distorting potentials to see which one gives the best convergence. We have also applied our results to several actual DWBA or coupled channel calculations in the literature. In addition to the study of models of two-body scattering systems, we have considered the case of rearrangement scattering. We have discussed the formulation of (N greater than or equal to 3)-body distorted wave equations in which the interior dynamics have been redistributed by introducing compact N-body distortion potentials

  18. Notes on Born-Infeld-type electrodynamics

    Science.gov (United States)

    Kruglov, S. I.

    2017-11-01

    We propose a new model of nonlinear electrodynamics (NLED) with three parameters. Born-Infeld (BI) electrodynamics and exponential electrodynamics are particular cases of this model. The phenomenon of vacuum birefringence in the external magnetic field is studied. We show that there is no singularity of the electric field at the origin of point-like charged particles. The corrections to Coulomb’s law at r →∞ are obtained. We calculate the total electrostatic energy of charges, for different parameters of the model, which is finite.

  19. Wormholes in Einstein-Born-Infeld Gravity

    Directory of Open Access Journals (Sweden)

    Kim Jin Young

    2018-01-01

    Full Text Available We introduce a new approach to construct wormholes without introducing exotic matters in Einstein-Born-Infeld gravity with a cosmological constant. Contary to the conventional approach, the throat is located at the place where the solutions can be joined smoothly. The metric and its derivatives are continuous so that the exotic matters are not needed there. The exoticity of the energy-momentum tensor is not essential to sustain the wormhole. We also present a method to check the stability of wormholes in the new approach.

  20. Born with Protection against Whooping Cough

    Centers for Disease Control (CDC) Podcasts

    2015-01-22

    This podcast provides information about whooping cough, a disease that can be deadly for babies, and CDC’s recommendation that all women receive the Tdap vaccine during the third trimester of every pregnancy so their babies can be born with protection from this serious disease.  Created: 1/22/2015 by National Center for Immunization and Respiratory Diseases (NCIRD), Division of Bacterial Diseases (DBD), Meningitis and Vaccine Preventable Diseases Branch (MVPDB).   Date Released: 1/22/2015.

  1. [Tick borne encephalitis and enviromental changes].

    Science.gov (United States)

    Zajkowska, Joanna; Malzahn, Elzbieta; Kondrusik, Maciej; Grygorczuk, Sambor; Pancewicz, Sławomir S; Kuśmierczyk, Justyna; Czupryna, Piotr; Hermanowska-Szpakowicz, Teresa

    2006-01-01

    Currently observed markedly increased incidence of various tick borne diseases in many parts of Europe is due to documented climatic changes as well anthropogenic influence on habitat structure. One of the analyzed factors is tendency to increase of the spring temperatures, especially in the third decade of the April. Such conditions (spring temperatures above 7-10 degrees C) let the nymphs and larvae of Ixodes ricinus to feed simultaneously on rodents. This increases the risk of infection of Ixodes ricinus with TBE virus, so dangerous for humans.

  2. MRI in tick-borne encephalitis

    International Nuclear Information System (INIS)

    Alkadhi, H.; Kollias, S.S.

    2000-01-01

    The tick-borne encephalitis (TBE) virus gives rise to epidemic encephalitis. Mild forms usually manifest as influenza-like episodes or are clinically silent. MRI is usually normal in TBE. We describe severe TBE in a patient who presented with fever and altered mental status after a tick bite and a specific antibody response to TBE. MRI revealed pronounced signal abnormalities in the basal ganglia and thalamus, without contrast enhancement. These findings coincide well with neuropathological studies of severe nerve cell degeneration with inflammatory cell infiltrates, neuronophagia and reactive astrocytosis in the deep grey matter. We review the literature and discuss the relevant differential diagnosis. (orig.)

  3. U.S.-born compared to non-U.S.-born abused women: analysis of baseline data.

    Science.gov (United States)

    Montalvo-Liendo, Nora; Koci, Anne; McFarlane, Judith; Gilroy, Heidi; Maddoux, John

    2013-01-01

    It is evident from recent studies that a woman's citizenship status does not exempt her from exposure to partner violence. The purpose of this article was to examine if social support, self-efficacy, and marginalization of abused women differ based on U.S. born compared to non-U.S. born with and without documentation. The findings suggest that women who were born in the United States had significantly higher self-efficacy scores compared to non-U.S.-born women without documents. There were no significant differences in social support among abused women who are U.S. born compared to non-U.S. born with and without documentation. In addition, women who were not born in the United States and did not have documents had higher marginalization.

  4. Social Trust and Children Born of War

    Directory of Open Access Journals (Sweden)

    Voicu Bogdan

    2014-12-01

    Full Text Available This paper considers two assumptions commonly used in analyzing the formation of social trust. They stress the importance of early socialization, on one hand, and of life events, on the other. We consider birth as a major life event for anyone and focus on the situation of Children Born of War. This group, even if lesser visible in some societies, has the peculiar characteristic to be born and socialized in very specific conditions. Typically, these people are the offspring of foreign soldiers, and local women. They may bear stigma, might be marginalized in family, school and society, and might develop a low level of generalized trust even if they may have lived all life in a culture rich in social trust. We explore at theoretical level their case, bring in a few statistics, and suggest a research direction that may be fruitful in learning about both such hidden populations and about social trust. In the end, we argue upon the importance of the topic for post-conflict societies.

  5. Open bite in prematurely born children.

    Science.gov (United States)

    Harila, V; Heikkinen, T; Grön, M; Alvesalo, L

    2007-01-01

    The aims of this study were to: examine the expression of open bite in prematurely born children and discuss the etiological factors that may lead to bite it. The subjects were 328 prematurely born (cross-sectional study of the Collaborative Perinatal Project in the 1960s and 1970s. Dental documents, including casts and photographs, were taken once at the age of 6-12 years in the mixed dentition. The occlusion was recorded by examining and measuring the hard stone casts. Vertical open bite was recorded only for full erupted teeth. The statistical method used was chi-square analysis. Significant differences in the incidence of anterior open bite (from left to right canine) was found between the preterm and control groups and between gender and ethnic groups. The prevalence of anterior open bite was nearly 9% in the preterm group and almost 7% in the control group. African Americans (9%) had a significantly greater incidence of open bite than Caucasians (3%; Pbite than boys (8% vs 6%; Pbite was increased--especially in preterm African American boys compared to controls (11% vs 8%). The results show differences in the development of anterior open bite between ethnic and gender groups. Premature birth may also influence dental occlusal development. Of importance are the patient's: general health condition; respiratory infections; inadequate nasal- and mouth-breathing; oral habits; and other medical problems. Preterm children may be relatively more predisposed to etiological factors for the development of anterior open bite.

  6. Canine vector-borne diseases in Brazil

    Science.gov (United States)

    Dantas-Torres, Filipe

    2008-01-01

    Canine vector-borne diseases (CVBDs) are highly prevalent in Brazil and represent a challenge to veterinarians and public health workers, since some diseases are of great zoonotic potential. Dogs are affected by many protozoa (e.g., Babesia vogeli, Leishmania infantum, and Trypanosoma cruzi), bacteria (e.g., Anaplasma platys and Ehrlichia canis), and helminths (e.g., Dirofilaria immitis and Dipylidium caninum) that are transmitted by a diverse range of arthropod vectors, including ticks, fleas, lice, triatomines, mosquitoes, tabanids, and phlebotomine sand flies. This article focuses on several aspects (etiology, transmission, distribution, prevalence, risk factors, diagnosis, control, prevention, and public health significance) of CVBDs in Brazil and discusses research gaps to be addressed in future studies. PMID:18691408

  7. Canine vector-borne diseases in Brazil

    Directory of Open Access Journals (Sweden)

    Dantas-Torres Filipe

    2008-08-01

    Full Text Available Abstract Canine vector-borne diseases (CVBDs are highly prevalent in Brazil and represent a challenge to veterinarians and public health workers, since some diseases are of great zoonotic potential. Dogs are affected by many protozoa (e.g., Babesia vogeli, Leishmania infantum, and Trypanosoma cruzi, bacteria (e.g., Anaplasma platys and Ehrlichia canis, and helminths (e.g., Dirofilaria immitis and Dipylidium caninum that are transmitted by a diverse range of arthropod vectors, including ticks, fleas, lice, triatomines, mosquitoes, tabanids, and phlebotomine sand flies. This article focuses on several aspects (etiology, transmission, distribution, prevalence, risk factors, diagnosis, control, prevention, and public health significance of CVBDs in Brazil and discusses research gaps to be addressed in future studies.

  8. Other impacts of soil-borne radionuclides

    International Nuclear Information System (INIS)

    Sheppard, S.C.; Macdonald, C.R.

    1996-01-01

    Soils surround us daily, and humans and animals are exposed to soil in more ways than simply through ingestion of plants. Despite strict personal and food-industry hygiene, some soil will always be present in our diet. This often involves the very fine soil particles known to be especially effective in sorbing radionuclides. The soil we ingest may come through skin contact or through soil adhering to crop plants and other foods. Inhalation of soil particles by humans and other animals must also be considered. Throughout the consideration of the impacts of soil-borne radionuclides, there must be recognition of potential impacts on non-human biota, and of non-radiological impacts. The chemical toxicity of long-lived radionuclides may be just as important as their radiological impact for non-human biota. These issues and associated assessment modelling approaches are discussed, with examples and data drawn from our research programs. (J.P.N.)

  9. Human sparganosis, a neglected food borne zoonosis.

    Science.gov (United States)

    Liu, Quan; Li, Ming-Wei; Wang, Ze-Dong; Zhao, Guang-Hui; Zhu, Xing-Quan

    2015-10-01

    Human sparganosis is a food borne zoonosis caused by the plerocercoid larvae (spargana) of various diphyllobothroid tapeworms of the genus Spirometra. Human infections are acquired by ingesting the raw or undercooked meat of snakes or frogs, drinking untreated water, or using raw flesh in traditional poultices. More than 1600 cases of sparganosis have been documented worldwide, mostly in east and southeast Asia. Sporadic cases have been reported in South America, Europe, and Africa, and several cases have been described in travellers returning from endemic regions. Epidemiological data suggest that the increased effect of sparganosis on human health is because of greater consumption of raw meat of freshwater frogs and snakes. This Review provides information about the Spirometra parasites and their lifecycles, summarises clinical features, diagnosis, and treatment of human sparganosis, and describes geographical distribution and infection characteristics of Spirometra parasites in host animals. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Risk based surveillance for vector borne diseases

    DEFF Research Database (Denmark)

    Bødker, Rene

    of samples and hence early detection of outbreaks. Models for vector borne diseases in Denmark have demonstrated dramatic variation in outbreak risk during the season and between years. The Danish VetMap project aims to make these risk based surveillance estimates available on the veterinarians smart phones...... in Northern Europe. This model approach may be used as a basis for risk based surveillance. In risk based surveillance limited resources for surveillance are targeted at geographical areas most at risk and only when the risk is high. This makes risk based surveillance a cost effective alternative...... sample to a diagnostic laboratory. Risk based surveillance models may reduce this delay. An important feature of risk based surveillance models is their ability to continuously communicate the level of risk to veterinarians and hence increase awareness when risk is high. This is essential for submission...

  11. Refractive index in generalized superconductors with Born-Infeld electrodynamics

    Science.gov (United States)

    Cheng, Jun; Pan, Qiyuan; Yu, Hongwei; Jing, Jiliang

    2018-03-01

    We investigate, in the probe limit, the negative refraction in the generalized superconductors with the Born-Infeld electrodynamics. We observe that the system has a negative Depine-Lakhtakia index in the superconducting phase at small frequencies and the greater the Born-Infeld corrections the larger the range of frequencies or the range of temperatures for which the negative refraction occurs. Furthermore, we find that the tunable Born-Infeld parameter can be used to improve the propagation of light in the holographic setup. Our analysis indicates that the Born-Infeld electrodynamics plays an important role in determining the optical properties of the boundary theory.

  12. Racial/ethnic disparities in obesity among US-born and foreign-born adults by sex and education.

    Science.gov (United States)

    Barrington, Debbie S; Baquero, Maria C; Borrell, Luisa N; Crawford, Natalie D

    2010-02-01

    This study examines sex and education variations in obesity among US- and foreign-born whites, blacks, and Hispanics utilizing 1997-2005 data from the National Health Interview Survey on 267,585 adults aged > or =18 years. After adjusting for various demographic, health, and socioeconomic factors via logistic regression, foreign-born black men had the lowest odds for obesity relative to US-born white men. The largest racial/ethnic disparity in obesity was between US-born black and white women. High educational attainment diminished the US-born black-white and Hispanic-white disparities among women, increased these disparities among men, and had minimal effect on foreign-born Hispanic-white disparities among women and men. Comprehension of these relationships is vital for conducting effective obesity research and interventions within an increasingly diverse United States.

  13. Differences in sleep habits, study time, and academic performance between US-born and foreign-born college students.

    Science.gov (United States)

    Eliasson, Arne H; Eliasson, Arn H; Lettieri, Christopher J

    2017-05-01

    To inform the design of a sleep improvement program for college students, we assessed academic performance, sleep habits, study hours, and extracurricular time, hypothesizing that there would be differences between US-born and foreign-born students. Questionnaires queried participants on bedtimes, wake times, nap frequency, differences in weekday and weekend sleep habits, study hours, grade point average, time spent at paid employment, and other extracurricular activities. Comparisons were made using chi square tests for categorical data and t tests for continuous data between US-born and foreign-born students. Of 120 participants (55 % women) with racial diversity (49 whites, 18 blacks, 26 Hispanics, 14 Asians, and 13 other), 49 (41 %) were foreign-born. Comparisons between US-born and foreign-born students showed no differences in average age or gender though US-born had more whites. There were no differences between US-born and foreign-born students for grade point averages, weekday bedtimes, wake times, or total sleep times. However, US-born students averaged 50 min less study time per day (p = 0.01), had almost 9 h less paid employment per week (14.5 vs 23.4 h per week, p = 0.001), and stayed up to socialize more frequently (63 vs 43 %, p = 0.03). Foreign-born students awakened an hour earlier and averaged 40 min less sleep per night on weekends. Cultural differences among college students have a profound effect on sleep habits, study hours, and extracurricular time. The design of a sleep improvement program targeting a population with diverse cultural backgrounds must factor in such behavioral variations in order to have relevance and impact.

  14. Prevalence of Hepatitis B Surface Antigen in US-Born and Foreign-Born Asian/Pacific Islander College Students

    Science.gov (United States)

    Quang, Yen N.; Vu, Joanne; Yuk, Jihey; Li, Chin-Shang; Chen, Moon; Bowlus, Christopher L.

    2010-01-01

    The prevalence of chronic hepatitis B (HBV) among college-age US-born Asian and Pacific Islanders (A/PI) is not well known. Objectives: To compare the prevalence of hepatitis B surface antigen (HBsAg) seropositivity in US-born to A/PI-born students at a public university. Participants: Undergraduate who self-identified themselves as A/PI. Results:…

  15. Young adult outcomes of children born to teen mothers: effects of being born during their teen or later years.

    Science.gov (United States)

    Lipman, Ellen L; Georgiades, Katholiki; Boyle, Michael H

    2011-03-01

    Children of teen mothers exhibit adverse outcomes through adolescence. It is unclear whether these adverse outcomes extend to adulthood and apply to all of her children, or only those born when she was a teen. We examine the associations between young adult functioning and being born to a teen mother aged ≤20 years at the time of birth (current teen), and being born to a teen mother later in her life (>21 years, prior teen). The 1983 Ontario Child Health Study (OCHS) and 2001 follow-up are used, including 2,355 participants 4 to 16 years old in 1983 with 2001 data. Using multilevel modeling we assessed the association between being born to a current versus prior teen mother, relative to a nonteen mother, and 2001 outcomes, controlling for individual and family level characteristics assessed in childhood. Being born to a teen mother (versus a nonteen mother) is associated with poorer educational achievement, life satisfaction, and personal income. Accounting for time of sample children's birth in teen mothers' lives, individuals born to current and prior teen mothers showed a ~0.8-year educational deficit, relative to individuals born to nonteen mothers in fully adjusted models. Individuals born to current teen mothers reported lower life satisfaction and personal income (-$7,262). There were no significant group differences at follow-up in mental or physical health between individuals born to nonteen mothers and those born to current or prior teen mothers. Although being born to a teen mother exerts a pervasive adverse effect on educational attainment, the adverse effects on life satisfaction and personal income appear to be selective for individuals born to a current teen mother. Further research is required to understand these differential effects. Copyright © 2011 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.

  16. Drone-borne GPR design: Propagation issues

    Science.gov (United States)

    Chandra, Madhu; Tanzi, Tullio Joseph

    2018-01-01

    In this paper, we shall address the electromagnetic wave propagation issues that are critical to determining the feasibility of a drone-borne ground-penetrating radar sensor for humanitarian applications, particularly in the context of disaster management. Frequency- and polarization-dependent scattering, attenuation and dispersion of radar signals penetrating into the sub-surface region will determine the applicability of a drone-mounted radar sensor capable of registering radar echoes for observing and monitoring sub-surface features. The functionality of the radar will thus be assessed depending on key radar parameters that include the central radar frequency, the modulation depth, and the mode of radar operation (pulsed FM, FM-CW), the antenna type, the available power-budget. In the analysis to be presented, the radar equation, together with the aforementioned propagation effects, will be used to simulate the signal strength of radar echoes under different conditions arising from the chosen key-radar parameters and the assumed physical properties of the sub-surface earth medium. The analysis to be presented will indicate whether or not the drone-borne ground-penetrating radar is a feasible system and if it could be constructed with the technologies available today. Taking into account the strict constraints involved to design drone applications for Public Protection and Disaster Relief (PPDR), the ideas developed hereafter are both prospective and exploratory. The objective is to see if a solution can be found in the near future. xml:lang="fr" Dans l'analyse présentée, l'équation radar, ainsi que les effets de propagation susmentionnés, serviront à simuler la puissance du signal des échos radar sous différentes conditions découlant des paramètres clés choisis et les propriétés physiques du milieu sous la surface. L'étude a pour objectif de démontrer si le système est réalisable et s'il peut être construit avec les technologies disponibles

  17. Functional outcome at school age of children born with gastroschisis

    NARCIS (Netherlands)

    Lap, Chiara C M M; Bolhuis, Sandra W; Van Braeckel, Koenraad J. A.; Reijneveld, Sijmen A.; Manten, Gwendolyn T. R.; Bos, Arend F.; Hulscher, Jan

    Objective: We aimed to determine motor, cognitive and behavioural outcomes of school aged children born with gastroschisis compared to matched controls. Study design: We compared outcomes of 16 children born with gastroschisis treated at the University Medical Center Groningen, the Netherlands,

  18. Tick-borne encephalitis: Pathogenesis and clinical implications

    Czech Academy of Sciences Publication Activity Database

    Růžek, Daniel; Dobler, G.; Mantke, O. D.

    2010-01-01

    Roč. 8, č. 4 (2010), s. 223-232 ISSN 1477-8939 R&D Projects: GA ČR GPP302/10/P438; GA MŠk(CZ) LC06009 Institutional research plan: CEZ:AV0Z60220518 Keywords : Tick-borne encephalitis * Tick-borne encephalitis virus * Pathogenesis * Clinical data Subject RIV: EE - Microbiology, Virology

  19. An investigation into the prevalence of water borne diseases in ...

    African Journals Online (AJOL)

    Water-borne diseases are the most prevalent infectious diseases in the developing countries especially in new settlements along the river. The present investigation was carried out to assess the prevalence rate of water-borne diseases among people residing near the left bank of River Ravi. This study has a descriptive ...

  20. Equine tick-borne infections in the Netherlands

    NARCIS (Netherlands)

    Butler, C.M.

    2012-01-01

    This thesis focuses on the emergence and establishment of equine tick-borne infections in the Netherlands, with particular attention to their diagnosis, clinical relevance and treatment. Four tick-borne agents (Borrelia burgdorferi, Theileria equi, Babesia caballi and Anaplasma phagocytophilum)

  1. Perinatal outcomes in 375 children born after oocyte donation

    DEFF Research Database (Denmark)

    Malchau, Sara S; Loft, Anne; Larsen, Elisabeth C

    2013-01-01

    To describe perinatal outcomes in children born after oocyte donation (OD) compared with in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and spontaneous conception (SC).......To describe perinatal outcomes in children born after oocyte donation (OD) compared with in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and spontaneous conception (SC)....

  2. Type specimens of Pectinidae (Bivalvia) described by Ignaz von Born

    NARCIS (Netherlands)

    Dijkstra, H.H.

    2009-01-01

    Born described in two publications (1778, 1780) the molluscs in the collection of Empress Maria Theresa (1717-1780), now in the Natural History Museum at Vienna. In this paper the Pectinidae type material is described. Ten new species were introduced of which Argopecten nucleus (Born, 1778) and

  3. Human to human transmission of arthropod-borne pathogens

    NARCIS (Netherlands)

    Martina, Byron E.; Barzon, Luisa; Pijlman, Gorben P.; Fuente, de la José; Rizzoli, Annapaola; Wammes, Linda J.; Takken, Willem; Rij, van Ronald P.; Papa, Anna

    2017-01-01

    Human-to-human (H2H) transmitted arthropod-borne pathogens are a growing burden worldwide, with malaria and dengue being the most common mosquito-borne H2H transmitted diseases. The ability of vectors to get infected by humans during a blood meal to further propel an epidemic depends on complex

  4. Human to human transmission of arthropod-borne pathogens

    NARCIS (Netherlands)

    Martina, B.E.; Barzon, L.; Pijlman, G.P.; Fuente, J. de la; Rizzoli, A.; Wammes, L.J.; Takken, W.; Rij, R.P. van; Papa, A.

    2017-01-01

    Human-to-human (H2H) transmitted arthropod-borne pathogens are a growing burden worldwide, with malaria and dengue being the most common mosquito-borne H2H transmitted diseases. The ability of vectors to get infected by humans during a blood meal to further propel an epidemic depends on complex

  5. Survey of spatial distribution of vector-borne disease in ...

    African Journals Online (AJOL)

    Neighborhood dogs may act as reservoirs and disseminators of vector-borne diseases in urban areas. Accordingly, the aim of this study was to ascertain the health status and the vector-borne pathogens infecting dogs living in public areas with high levels of human movement in the city of Curitiba, southern Brazil.

  6. Atopic diseases in twins born after assisted reproduction

    DEFF Research Database (Denmark)

    Jäderberg, Ida; Thomsen, Simon F; Kyvik, Kirsten Ohm

    2012-01-01

    Jäderberg I, Thomsen SF, Kyvik KO, Skytthe A, Backer V. Atopic diseases in twins born after assisted reproduction. Paediatric and Perinatal Epidemiology 2012; 26: 140-145. We examined the risk of atopic diseases in twins born after assisted reproduction. Data on atopic diseases and assisted...... reproduction in 9694 twin pairs, 3-20 years of age, from the Danish Twin Registry were collected via multidisciplinary questionnaires. The risk of atopic diseases in twins born after assisted reproduction was compared with the risk in twins born after spontaneous conception using logistic regression...... and variance components analysis. Children born after assisted reproduction did not have a different risk of atopic outcomes (adjusted odds ratios [95% confidence intervals] for asthma: 0.95 [0.85, 1.07], P = 0.403; hay fever: 1.01 [0.86, 1.18], P = 0.918; and atopic dermatitis: 1.02 [0.81, 1.11], P = 0...

  7. Newer Vaccines against Mosquito-borne Diseases.

    Science.gov (United States)

    Aggarwal, Anju; Garg, Neha

    2018-02-01

    Mosquitos are responsible for a number of protozoal and viral diseases. Malaria, dengue, Japanese encephalitis (JE) and chikungunya epidemics occur commonly all over the world, leading to marked mortality and morbidity in children. Zika, Yellow fever and West Nile fever are others requiring prevention. Environmental control and mosquito bite prevention are useful in decreasing the burden of disease but vaccination has been found to be most cost-effective and is the need of the hour. RTS,S/AS01 vaccine is the first malaria vaccine being licensed for use against P. falciparum malaria. Dengvaxia (CYD-TDV) against dengue was licensed first in Mexico in 2015. A Vero-cell derived, inactivated and alum-adjuvanted JE vaccine based on the SA14-14-2 strain was approved in 2009 in North America, Australia and various European countries. It can be used from 2 mo of age. In India, immunization is carried out in endemic regions at 1 y of age. Another inactivated Vero-cell culture derived Kolar strain, 821564XY, JE vaccine is being used in India. Candidate vaccines against dengue, chikungunya and West Nile fever are been discussed. A continued research and development of new vaccines are required for controlling these mosquito-borne diseases.

  8. The neonate was born with holoprosencephaly

    Directory of Open Access Journals (Sweden)

    reza saeidi

    2014-12-01

    Full Text Available holoprosencephaly is a rare congenital brain malformation resulting from failure of diverticulation and cleavage of primitive prosencephalon which occurs at 4 - 8th week of gestation and is usually associated with multiple midline facial anomalies. it is the most common forebrain developmental anomaly in humans with prevalence of 1/16,000 in live borns, an incidence as high as 1:250 in conceptuses, and a worldwide distribution6. The etiology of HPE is very heterogeneous. First, this pathology can be caused by environmental or metabolic factors. The only formally recognized environmental factors are insulin-dependent diabetes mellitus (1% risk of HPE and maternal alcoholism with a risk that cumulates with smoking . Clinical expression is variable, extending in unbroken sequence from a small brain with a single cerebral ventricle and cyclopia to clinically unaffected carriers in familial holoprosencephaly. Here. we report a boy 39 weeks neonatal case of holoprosencephaly with Antenatal ultrasonographic diagnosis, with microcephaly, hypotelorism, flat nose, a single nostril, a midline cleft lip and palate microcephaly.

  9. BAT-BORNE RABIES IN LATIN AMERICA

    Directory of Open Access Journals (Sweden)

    Luis E. Escobar

    2015-02-01

    Full Text Available The situation of rabies in America is complex: rabies in dogs has decreased dramatically, but bats are increasingly recognized as natural reservoirs of other rabies variants. Here, bat species known to be rabies-positive with different antigenic variants, are summarized in relation to bat conservation status across Latin America. Rabies virus is widespread in Latin American bat species, 22.5%75 of bat species have been confirmed as rabies-positive. Most bat species found rabies positive are classified by the International Union for Conservation of Nature as “Least Concern”. According to diet type, insectivorous bats had the most species known as rabies reservoirs, while in proportion hematophagous bats were the most important. Research at coarse spatial scales must strive to understand rabies ecology; basic information on distribution and population dynamics of many Latin American and Caribbean bat species is needed; and detailed information on effects of landscape change in driving bat-borne rabies outbreaks remains unassessed. Finally, integrated approaches including public health, ecology, and conservation biology are needed to understand and prevent emergent diseases in bats.

  10. Born Pupils? Natural Pedagogy and Cultural Pedagogy.

    Science.gov (United States)

    Heyes, Cecilia

    2016-03-01

    The theory of natural pedagogy is an important focus of research on the evolution and development of cultural learning. It proposes that we are born pupils; that human children genetically inherit a package of psychological adaptations that make them receptive to teaching. In this article, I first examine the components of the package-eye contact, contingencies, infant-directed speech, gaze cuing, and rational imitation-asking in each case whether current evidence indicates that the component is a reliable feature of infant behavior and a genetic adaptation for teaching. I then discuss three fundamental insights embodied in the theory: Imitation is not enough for cumulative cultural inheritance, the extra comes from blind trust, and tweaking is a powerful source of cognitive change. Combining the results of the empirical review with these insights, I argue that human receptivity to teaching is founded on nonspecific genetic adaptations for social bonding and social learning and acquires its species- and functionally specific features through the operation of domain-general processes of learning in sociocultural contexts. We engage, not in natural pedagogy, but in cultural pedagogy. © The Author(s) 2016.

  11. Born-Kothari Condensation for Fermions

    Directory of Open Access Journals (Sweden)

    Arnab Ghosh

    2017-09-01

    Full Text Available In the spirit of Bose–Einstein condensation, we present a detailed account of the statistical description of the condensation phenomena for a Fermi–Dirac gas following the works of Born and Kothari. For bosons, while the condensed phase below a certain critical temperature, permits macroscopic occupation at the lowest energy single particle state, for fermions, due to Pauli exclusion principle, the condensed phase occurs only in the form of a single occupancy dense modes at the highest energy state. In spite of these rudimentary differences, our recent findings [Ghosh and Ray, 2017] identify the foregoing phenomenon as condensation-like coherence among fermions in an analogous way to Bose–Einstein condensate which is collectively described by a coherent matter wave. To reach the above conclusion, we employ the close relationship between the statistical methods of bosonic and fermionic fields pioneered by Cahill and Glauber. In addition to our previous results, we described in this mini-review that the highest momentum (energy for individual fermions, prerequisite for the condensation process, can be specified in terms of the natural length and energy scales of the problem. The existence of such condensed phases, which are of obvious significance in the context of elementary particles, have also been scrutinized.

  12. Ventilatory Efficiency in Children and Adolescents Born Extremely Preterm

    Directory of Open Access Journals (Sweden)

    Julie Hestnes

    2017-07-01

    Full Text Available Purpose: Children and adolescents born extremely preterm (EP have lower dynamic lung volumes and gas transfer capacity than subjects born at term. Most studies also report lower aerobic capacity. We hypothesized that ventilatory efficiency was poorer and that breathing patterns differed in EP−born compared to term−born individuals.Methods: Two area−based cohorts of participants born with gestational age ≤28 weeks or birth weight ≤1000 g in 1982−85 (n = 46 and 1991–92 (n = 35 were compared with individually matched controls born at term. Mean ages were 18 and 10 years, respectively. The participants performed an incremental treadmill exercise test to peak oxygen uptake with data averaged over 20 s intervals. For each participant, the relationship between exhaled minute ventilation (V˙E and carbon dioxide output (V˙CO2 was described by a linear model, and the relationship between tidal volume (VT and V˙E by a quadratic model. Multivariate regression analyses were done with curve parameters as dependent variables, and the categories EP vs. term−born, sex, age, height, weight and forced expiratory volume in 1 s (FEV1 as independent variables.Results: In adjusted analyses, the slope of the V˙E−V˙CO2 relationship was significantly steeper in the EP than the term-born group, whereas no group difference was observed for the breathing pattern, which was related to FEV1 only.Conclusion: EP-born participants breathed with higher V˙E for any given CO2 output, indicating lower ventilatory efficiency, possibly contributing to lower aerobic capacity. The breathing patterns did not differ between the EP and term−born groups when adjusted for FEV1.

  13. Three-dimensional prospective evaluation of tooth-borne and bone-borne surgically assisted rapid maxillary expansion

    NARCIS (Netherlands)

    Nada, R.M.; Fudalej, P.S.; Maal, T.J.J.; Berge, S.J.; Mostafa, Y.A.; Kuijpers-Jagtman, A.M.

    2012-01-01

    AIM: To three-dimensionally (3D) assess the long-term effects of tooth-borne and bone-borne surgically assisted rapid maxillary expansion (SARME). SUBJECTS AND METHODS: This prospective cohort study comprised 45 consecutive skeletally mature non-syndromic patients with transverse maxillary

  14. Young Adult Outcomes of Children Born to Teen Mothers: Effects of Being Born during Their Teen or Later Years

    Science.gov (United States)

    Lipman, Ellen L.; Georgiades, Katholiki; Boyle, Michael H.

    2011-01-01

    Objective: Children of teen mothers exhibit adverse outcomes through adolescence. It is unclear whether these adverse outcomes extend to adulthood and apply to all of her children, or only those born when she was a teen. We examine the associations between young adult functioning and being born to a teen mother aged less than or equal to 20 years…

  15. Comparison outcomes of sick babies born to teenage mothers with those born to adult mothers.

    Science.gov (United States)

    Chotigeat, Uraiwan; Sawasdiworn, Siraporn

    2011-08-01

    Adolescent period is the transitional stage of physical and mental development from childhood to adulthood. Pregnancy in teenage girls is generally classified to have a higher risk than those in adults. In many previous studies reported only the outcome of teenage mothers but no comparative outcome between sick babies born to teen mothers and adult mothers, so the authors conducted the present study. To compare the outcomes of sick infants born to teenage mothers with those born to adult mothers (age > or = 20 years). This prospective study was carried out from October 1st, 2006 to September 30th, 2009. The study group consisted of sick babies born to teenage mothers and admitted at Queen Sirikit National Institute of Child Health (QSNICH). These babies were compared to sick babies (control group) born to adult mothers during the same period. The demographic data of mothers and sick babies in both groups were recorded in the designed case record forms. Developmental assessment was done until two years of age. A total of 6,342 deliveries took place in Rajavithi Hospital during the study period of which 697 babies were born to teenage mothers. The incidence of teenage pregnancy was 10.99%. The number of sick babies from teenage mothers and adult mothers were 78 and 147 cases, respectively. There was a significantly higher mortality in the study group (7 cases, 9%) than the control group (4 cases, 2.7%). There was statistically significant difference in most of the demographic characteristics between the teenage and adult mothers except anemia, PROM and MSAF (meconium stain amniotic fluid). Although there was a trend of more cases of anemia and MSAF in teenage mothers than in adult mothers, there was no statistically significant difference. There was a shorter interval time from marriage to pregnancy in teen mothers than in adult mothers and a lower number of antenatal care visits with late antenatal care among the teenage mothers too. On comparing the data in infants

  16. Children born to SLE and APS mothers.

    Science.gov (United States)

    Nalli, C; Iodice, A; Andreoli, L; Lojacono, A; Motta, M; Fazzi, E; Tincani, A

    2014-10-01

    Systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome (APS) are autoimmune diseases that affect women of childbearing age. Pregnancies in these patients carry several complications such as prematurity. Maternal IgG antiphospholipid antibodies (aPL) can cross the placenta but they don't generally cause any neonatal thrombotic event. Because of the incompleteness of the fetal blood-brain barrier, aPL could theoretically reach the fetal brain. Whether this can have an effect on brain development is still under investigation. Some studies performed in children of patients with SLE and/or APS showed an increased number of learning disabilities without impairment in intelligence level. The objectives of this article are to evaluate the neurodevelopment outcome in 30 children (median age 9 years) born to mothers with SLE and/or APS with IgG anti-beta2-glycoprotein I during the third trimester of pregnancy and found positive for the same antibodies at birth. A neurological physical exam was performed in all children. We submitted some questionnaires to the mothers: the Child Behavior CheckList (CBCL) and a homemade set of questions obtained by a team composed of rheumatologists and pediatric neurologists. Intellectual functioning was determined by the Wechsler scale for corrected age. In all children neurological physical exam and intelligence levels were found to be normal but mild behavior disorders and history of neurological manifestations were shown in three children. Offspring of patients with SLE and/or APS are generally healthy. We and others observed the occurrence of minor neurological disorders that might be related to maternal disease or to prematurity. The limited number of the available data on this sensitive issue supports the need for further studies. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  17. COLLISIONALLY BORN FAMILY ABOUT 87 SYLVIA

    International Nuclear Information System (INIS)

    Vokrouhlicky, David; Nesvorny, David; Bottke, William F.; Morbidelli, Alessandro

    2010-01-01

    There are currently more than 1000 multi-opposition objects known in the Cybele population, adjacent and exterior to the asteroid main belt, allowing a more detailed analysis than was previously possible. Searching for collisionally born clusters in this population, we find only one statistically robust case: a family of objects about (87) Sylvia. We use a numerical model to simulate the Sylvia family long-term evolution due to gravitational attraction from planets and thermal (Yarkovsky) effects and to explain its perturbed structure in the orbital element space. This allows us to conclude that the Sylvia family must be at least several hundreds of million years old, in agreement with evolutionary timescales of Sylvia's satellite system. We find it interesting that other large Cybele-zone asteroids with known satellites-(107) Camilla and (121) Hermione-do not have detectable families of collisional fragments about them (this is because we assume that binaries with large primary and small secondary components are necessarily impact generated). Our numerical simulations of synthetic clusters about these asteroids show they would suffer a substantial dynamical depletion by a combined effect of diffusion in numerous weak mean-motion resonances and Yarkovsky forces provided their age is close to ∼4 billion years. However, we also believe that a complete effacement of these two families requires an additional component, very likely due to resonance sweeping or other perturbing effects associated with the late Jupiter's inward migration. We thus propose that both Camilla and Hermione originally had their collisional families, as in the Sylvia case, but they lost them in an evolution that lasted a billion years. Their satellites are the only witnesses of these effaced families.

  18. Los sentimientos morales de la «tristeza» china. Una ilustración del acercamiento del Metalenguaje Semántico Natural (MSN al análisis de algunas emociones chinas «básicas»

    Directory of Open Access Journals (Sweden)

    Ye, Zhengdao

    2001-12-01

    Full Text Available This study undertakes, under the framework of Natural Semantic Metlanguage (NSM developed by Anna Wierzbicka and colleagues, a detailed contrastive and comparative semantic analysis of a pair of emotions concepts: bei and ai (often glossed interchangeably as sadness, sorrow, and grief, which are considered to be basic emotions in traditional Chinese philosophical texts. It illustrates that (a they are by no means interchangeable, nor are they equivalent of the Western idea of sadness, (b they are artifacts of the Chinese culture, shaped by Chinese people’s social and moral experiences, and their view of life and the universe. Essentially, bei encompasses a fatalistic view, and ai is a moral emotion. This leads the author to challenge the claims of universality based on the view entrenched in the English language, and urges researchers to pay attention to the analytical framework employed in the search for universal aspects of human emotions.

    Este estudio emprende, desde el marco del Metalenguaje Semántico Natural (MSN desarrollado por Wierzbicka y algunos colegas, un detallado análisis semántico contrastivo y comparativo de dos conceptos de emoción: bei y ai (a menudo glosados de manera intercambiable como tristeza, pena y dolor, que son considerados como emociones básicas en los textos filosóficos chinos tradicionales. En él se demuestra que: a de ninguna manera son intercambiables, ni equivalentes a la idea occidental de tristeza, b son artefactos de la cultura china, conformados por las experiencias morales y sociales del pueblo chino y su visión de la vida y del universo. En esencia, bei comporta una visión fatalista y ai es una emoción moral. Esto lleva a la autora a poner en duda el postulado de universalidad basado en la visión arraigada en la lengua inglesa, y llama a los investigadores a prestar atención al marco

  19. First-born siblings show better second language skills than later born siblings

    Science.gov (United States)

    Keller, Karin; Troesch, Larissa M.; Grob, Alexander

    2015-01-01

    We examined the extent to which three sibling structure variables number of siblings, birth order, and presence of an older sibling at school age are linked to the second language skills of bilingual children. The research questions were tested using an ethnically heterogeneous sample of 1209 bilingual children with German as a second language. Controlling for children’s age, sex, nationality, number of children’s books at home, family language and parental German language skills, hierarchical regression analyses showed an inverse relationship between the number of siblings and second language skills: the more siblings a child had, the lower was his/her second language proficiency. This relationship was mediated by attendance in early education institutions. Moreover, first-born siblings showed better second language skills than later born siblings. The current study revealed that the resource dilution model, i.e., the decrease in resources for every additional sibling, holds for second language acquisition. Moreover, the results indicate that bilingual children from families with several children benefit from access to early education institutions. PMID:26089806

  20. First-born siblings show better second language skills than later born siblings

    Directory of Open Access Journals (Sweden)

    Karin eKeller

    2015-06-01

    Full Text Available We examined the extent to which three sibling structure variables number of siblings, birth order and presence of an older sibling at school age are linked to the second language skills of bilingual children. The research questions were tested using an ethnically heterogeneous sample of 1209 bilingual children with German as a second language. Controlling for children’s age, sex, nationality, number of children’s books at home, family language and parental German language skills, hierarchical regression analyses showed an inverse relationship between the number of siblings and second language skills: The more siblings a child had, the lower was his/her second language proficiency. This relationship was mediated by attendance in early education institutions. Moreover, first-born siblings showed better second language skills than later born siblings.The current study revealed that the resource dilution model, i.e., the decrease in resources for every additional sibling, holds for second language acquisition. Moreover, the results indicate that bilingual children from families with several children benefit from access to early education institutions.

  1. Spectroscopic studies on colloid-borne uranium

    International Nuclear Information System (INIS)

    Ulrich, K.U.; Weiss, S.; Foerstendorf, H.; Brendler, V.; Zaenker, H.; Rossberg, A.; Scheinost, A.C.

    2005-01-01

    Full text of publication follows: Information on molecular speciation provides a basis for the reliable assessment of actinide migration in the environment. We use several methods for the separation of colloids from liquids (e.g. ultracentrifugation, ultrafiltration) in combination with spectroscopic techniques (EXAFS, ATR-FTIR, Moessbauer) and modeling of surface complexation reactions. This enables us to investigate the speciation of colloid-borne uranium in waters occurring in or escaping from abandoned uranium mines during the remediation process. Mine flooding was simulated on a 100 L scale by mixing acid mine water of elevated U concentration with oxic, near-neutral groundwater until pH ∼ 5.5 was reached. The freshly formed colloids adsorbed 95% of the total uranium and consisted mainly of 2-line ferri-hydrite (Fh) besides traces of aluminum, sulfur, silica, and carbon compounds. EXAFS analysis at the U-LIII absorption edge suggested a bidentate surface complex of UO 2 2+ on FeO 6 octahedra, but two minor backscattering contributions in close vicinity to the absorber remained unexplained. Since only Al could be excluded as backscattering atom, we studied U sorption on Fh at pH 5.5 in presence and in absence of sulfate, silicate, and atmospheric CO 2 to clarify the bond structure. EXAFS showed the unknown backscattering contributions in all the sorption samples regardless of the presence or absence of the tested components. Contrary to structural models proposed in the literature, bi-dentately complexed carbonate ligands do not explain our experimental EXAFS data. But ATR-IR spectra showed that U-carbonato complexes must be involved in the sorption of uranyl on Fh. These results are not contradictory if the carbonate ligands were bound mono-dentately. Nevertheless, carbon cannot act as backscattering atom in carbonate-free samples prepared in N 2 atmosphere. We propose a new structural model including exclusively Fe, H, and O atoms in which the bi

  2. Multidrug-resistant pattern of food borne illness associated bacteria ...

    African Journals Online (AJOL)

    This study aimed at determining anti-microbial resistance pattern of food borne illness ... bial drugs in the pharmaceutical pipeline.2 The effective- ness of ... Materials and methods ... selected based on local availability, clinical efficiency, liter-.

  3. Episodic recruitment of the rock oyster Saccostrea cucullata (Born ...

    African Journals Online (AJOL)

    Episodic recruitment of the rock oyster Saccostrea cucullata (Born, 1778) on the Transkei coast. ... This single recruitment, which is 6 to 31 times the annual mean recorded over the last 6 to 7 years, represents 5 ... AJOL African Journals Online.

  4. Association of water-borne diseases morbidity pattern and water ...

    African Journals Online (AJOL)

    1Department of Env ronmental Management and Tox cology, Un vers ty of Agr culture, PMB 2240,. Abeokuta, Ogun .... and a modern sector) that has implications for ... plastered with cement. ..... residents are at–risk of water-borne diseases.

  5. Field scale manure born animal waste management : GIS application

    Science.gov (United States)

    Intensive beef backgrounding often accumulate manure born soil nutrients, microbes, and pharmaceuticals at different site locations. Unless properly managed, such waste materials can pollute surrounding soil and water sources. Soil sampling from these sites helps determining waste material levels bu...

  6. Thermostating extended Lagrangian Born-Oppenheimer molecular dynamics.

    Science.gov (United States)

    Martínez, Enrique; Cawkwell, Marc J; Voter, Arthur F; Niklasson, Anders M N

    2015-04-21

    Extended Lagrangian Born-Oppenheimer molecular dynamics is developed and analyzed for applications in canonical (NVT) simulations. Three different approaches are considered: the Nosé and Andersen thermostats and Langevin dynamics. We have tested the temperature distribution under different conditions of self-consistent field (SCF) convergence and time step and compared the results to analytical predictions. We find that the simulations based on the extended Lagrangian Born-Oppenheimer framework provide accurate canonical distributions even under approximate SCF convergence, often requiring only a single diagonalization per time step, whereas regular Born-Oppenheimer formulations exhibit unphysical fluctuations unless a sufficiently high degree of convergence is reached at each time step. The thermostated extended Lagrangian framework thus offers an accurate approach to sample processes in the canonical ensemble at a fraction of the computational cost of regular Born-Oppenheimer molecular dynamics simulations.

  7. Rickettsial and other tick-borne infections.

    Science.gov (United States)

    Flicek, Barbara Fouts

    2007-03-01

    prophylaxsis is beneficial to the tick-bitten patient to prevent disease. It must be kept in mind that the risk of transmission of disease increases with the duration of attachment and generally requires greater than 24 to 48 hours. The degree of tick engorgement or the time since tick exposure and discovery of the tick may be used to establish the likely duration of attachment and the risk of disease transmission. Reducing and controlling tick populations is difficult. Habitat modifications, including vegetation management by cutting, burning, and herbicide treatment, and drainage of wet areas are one strategy for tick control, but their effects are often short-lived, and they can cause severe ecologic damage. Chemicals used to control ticks may cause environmental contamination, and therefore, toxicity for humans and animals. Biologic control methods for ticks include the promotion of natural predators. Natural predators of ticks are beetles, spiders, and ants, and parasites such as insects, mites and nematodes. Tick control is best based on the concept of integrated pest management, in which different control methods are adapted to one area or against one tick species with due consideration to their environmental effects. Tick-borne diseases are increasing in prevalence. Perhaps it is because people are undertaking more outdoor activities, which result in contact with ticks and their pathogens. Clinicians should be aware of the clinical sign of tick-transmitted diseases, because morbidity and mortality as a result of these diseases increases substantially if there are delays in diagnosis and treatment. Tick-borne illness occur in distinctive geographic areas. The reporting of these illnesses and diseases to the health department enables the gathering of information and statistics. The public should be informed about the risks of disease in tick-infested areas and the means of preventing infections. The most common diseases are caused by Rickettsia, Borrelia, and Ehrichia

  8. Stability of a Tick-Borne Flavivirus in Milk

    OpenAIRE

    Offerdahl, Danielle K.; Clancy, Niall G.; Bloom, Marshall E.

    2016-01-01

    The tick-borne flaviviruses (TBFV) occur worldwide and the tick-borne encephalitis virus (TBEV) members of the group often cause severe, debilitating neurological disease in humans. Although the primary route of infection is through the bite of an infected tick, alimentary infection through the consumption of TBEV-contaminated dairy products is also well-documented and is responsible for some disease in endemic areas. Experimental infection of goats, cattle, and sheep with TBEV shows that the...

  9. Rapid Identification of Vector-Borne Flaviviruses by Mass Spectrometry

    Science.gov (United States)

    2010-02-01

    Eastern, and Siberian subtypes [9]. Several tick-borne flaviviruses can also cause hemorrhagic disease. Important examples of these viruses include...assay. Identical base compositions within a column are the same color. Unique base compositions are shown with white backgrounds. (For interpretation...States, 1999e2005. Vector Borne Zoonotic Dis 2008;8:733e40. [18] Hofstadler SA, Sampath R, Blyn LB, Eshoo MW, Hall TA, Jiang Y, et al. TIGER : the

  10. Mandibular function, temporomandibular disorders, and headache in prematurely born children.

    Science.gov (United States)

    Paulsson, Liselotte; Ekberg, Ewacarin; Nilner, Maria; Bondemark, Lars

    2009-01-01

    To evaluate mandibular function, signs, and symptoms of temporomandibular disorders (TMDs) and headache in prematurely born 8- to 10-year-old children, and to compare the findings with matched full-term born controls. Seventy-three preterm children were selected from the Medical Birth Register--one group comprising 36 extremely preterm children born before the 29th gestational week, the other group 37 very preterm children born during gestational weeks 29 to 32. The preterm children were compared with a control group of 41 full-term children matched for gender, age, nationality, and living area. The subjective symptoms of TMD and headache were registered using a questionnaire. Mandibular function, signs, and symptoms of TMD and headache were registered. TMD diagnoses were set per Research Diagnostic Criteria for temporomandibular disorders (RDC/TMD). No significant differences between groups or gender were found for TMD diagnoses according to RDC/TMD or for headache. The preterm children had smaller mandibular movement capacity than the full-term control group, but when adjusting for weight, height, and head circumference mostly all group differences disappeared. Prematurely born children of 8 to 10 years of age did not differ from full-term born children when considering diagnoses according to RDC/TMD, signs, and symptoms of TMD or headache.

  11. Preschool abilities of children born preterm and low weight

    Directory of Open Access Journals (Sweden)

    Sasha A. Martínez-Espiet

    2018-10-01

    Full Text Available The purpose of this study was to evaluate the development among a group of pre-school children born premature and with low weight. We evaluated a group of four years old children; 20 children born prematurely and 20 children born after a full gestation and desired weight, using the Beery-Buktenica visual-motor integration test. We also administered the Ages and Stages Questionnaire (ASQ-3 development test to all 40 mothers. Statistical analysis was performed using student t test for independent groups. The group of children born prematurely scored significantly lower on tests measuring visual perception skills (µ1 83.65 ; µ2 93.7 (p = 0.0001, visual-motor integration (µ1 93.6 ; µ2 104.8 (p = 0.001 and fine motor (µ1 36.00 ; µ2 44.25 (p=0.033 (p = 0.033, when compared to the group of children born after a full term. This study suggests that premature low weight born children have lower performance in the sensory-motor development during the preschool years. These disadvantages go unnoticed and may represent future delays on school tasks that require these skills. It is important to promote an early assessment and environmental stimulation among this population even in the absence of risk indicators.

  12. Balance in children born prematurely currently aged 6–7

    Directory of Open Access Journals (Sweden)

    Dziuba Ewa

    2017-12-01

    Full Text Available Study aim: Premature birth is one of the major problems of obstetrics, leading to numerous complications that are associated with prematurity, for instance balance disorders. The aim of the study was to assess the impact of premature birth on the ability to maintain balance in children commencing their school education. Material and methods: The study included children aged 6-7 years. The study group consisted of 59 children (31 girls and 28 boys, mean age 6.38 ± SD 0.73 born prematurely between 24 and 35 weeks of gestation. The control group consisted of 61 children (28 girls and 33 boys, mean age 6.42 ± 0.58 born at term. The research utilized standardized test tools - one-leg open-eyed and closed-eyed standing test, one-leg jumping test - and an original questionnaire survey. Results: The children born at term achieved better results in the majority of tests. The comparison of girls and boys born pre­maturely and at term showed no statistically significant difference between them in terms of dynamic balance, static balance or total balance control. The comparison of the tests performed on the right and left lower limb in prematurely born children showed no statistically significant differences. Conclusion: Premature birth affects the ability to maintain body balance. The results of the study indicate the need to develop coordination skills that shape body balance in prematurely born children.

  13. Magic moment? Maternal marriage for children born out of wedlock.

    Science.gov (United States)

    Gibson-Davis, Christina

    2014-08-01

    To test the existence of the "magic moment" for parental marriage immediately post-birth and to inform policies that preferentially encourage biological over step parent marriage, this study estimates the incidence and stability of maternal marriage for children born out of wedlock. Data came from the National Survey of Family Growth on 5,255 children born non maritally. By age 15, 29 % of children born non maritally experienced a biological-father marriage, and 36 % experienced a stepfather marriage. Stepfather marriages occurred much later in a child's life-one-half occurred after the child turned age 7-and had one-third higher odds of dissolution. Children born to black mothers had qualitatively different maternal marriage experiences than children born to white or Hispanic mothers, with less biological-parent marriage and higher incidences of divorce. Findings support the existence of the magic moment and demonstrate that biological marriages were more enduring than stepfather marriages. Yet relatively few children born out of wedlock experienced stable, biological-parent marriages as envisioned by marriage promotion programs.

  14. Neurocognitive outcome in young adults born late-preterm.

    Science.gov (United States)

    Heinonen, Kati; Lahti, Jari; Sammallahti, Sara; Wolke, Dieter; Lano, Aulikki; Andersson, Sture; Pesonen, Anu-Katriina; Eriksson, Johan G; Kajantie, Eero; Raikkonen, Katri

    2018-03-01

    This study examined whether late-preterm birth (34+0 to 36+6wks+d gestational age) was associated with neurocognitive deficit in young adulthood, and whether small for gestational age (SGA) birth amplified any adversity. Participants derived from the prospective regional cohort study, the Arvo Ylppö Longitudinal Study (n=786; 398 females, 388 males) (mean age 25y 4mo, SD 8mo), born 1985 to 1986 late-preterm (n=119; 21 SGA, intelligence, executive functioning, attention, and memory, and reported their education. Those born late-preterm scored -3.71 (95% confidence interval [CI] -6.71 to -0.72) and -3.11 (95% CI -6.01 to -0.22) points lower on Full-scale and Verbal IQ than peers born at term. Compared with those born at term and appropriate for gestational age (≥-2 to increase the risk of poorer neurocognitive functioning in adulthood. But the double burden of being born late-preterm and SGA seems to increase this risk. Late-preterm birth did not increase the risk of poorer neurocognitive functioning in adulthood. But the double burden of being born late-preterm and being small for gestational age did increase this risk. © 2017 Mac Keith Press.

  15. Air travel and vector-borne disease movement.

    Science.gov (United States)

    Tatem, A J; Huang, Z; Das, A; Qi, Q; Roth, J; Qiu, Y

    2012-12-01

    Recent decades have seen substantial expansions in the global air travel network and rapid increases in traffic volumes. The effects of this are well studied in terms of the spread of directly transmitted infections, but the role of air travel in the movement of vector-borne diseases is less well understood. Increasingly however, wider reaching surveillance for vector-borne diseases and our improving abilities to map the distributions of vectors and the diseases they carry, are providing opportunities to better our understanding of the impact of increasing air travel. Here we examine global trends in the continued expansion of air transport and its impact upon epidemiology. Novel malaria and chikungunya examples are presented, detailing how geospatial data in combination with information on air traffic can be used to predict the risks of vector-borne disease importation and establishment. Finally, we describe the development of an online tool, the Vector-Borne Disease Airline Importation Risk (VBD-Air) tool, which brings together spatial data on air traffic and vector-borne disease distributions to quantify the seasonally changing risks for importation to non-endemic regions. Such a framework provides the first steps towards an ultimate goal of adaptive management based on near real time flight data and vector-borne disease surveillance.

  16. Optimization of Road Project Financing Mode in Yunnan Province Based on ANP%基于ANP的云南省公路项目融资模式优选研究

    Institute of Scientific and Technical Information of China (English)

    孟笋; 张铖

    2015-01-01

    To select the optimal financing mode of the road projects in Yunnan Province,this study described the foreign and domestic research about the financing modes of the road projects,and the problems occurred in the process of the project financing. Based on ANP,this study took a road project constructed by Kunming Industrial Development and Investment Company for example to analyze the factors that influence the project financing and the optimal financing mode, then analyzed the reasons of the optimal financing mode selection and proposed suggestions to improve the financing environment on the basis of the actual situation in Yunnan Province. This study has theoretical and practical significance,and has referential value for the road project financing in the other provinces.%为解决云南省公路项目最优融资模式选择问题,阐述了国内外关于公路项目融资模式的研究成果和公路项目融资过程中出现的问题及研究的必要性,运用ANP模型,以昆明产业投资开发有限责任公司承建的某公路项目为例,分析对云南省公路项目融资影响最大的因素及其最优的融资模式。结合云南省实际情况,分析最优融资模式的选择原因,并对云南省如何改善项目融资环境提出建议和对策,具有理论和实践双重意义,对我国其他省份的公路项目融资问题研究也有参考价值。

  17. Offending Behavior, Drug Use, and Mental Health Among Foreign-Born versus U.S. Born Latino Criminal Justice Clients.

    Science.gov (United States)

    Ibañez, Gladys E; Agudo, Michelle; Martin, Steve S; O'Connell, Daniel J; Auf, Rehab; Sheehan, Diana M

    2017-06-01

    Little is known about the offending behavior and recidivism factors of Latinos by nativity (U.S. born, foreign-born). The present study focused on Latinos in community corrections (n = 201) in Miami, Florida, and examined differences in criminal activity, drug use, and mental health by nativity. Data were collected utilizing convenience sampling between June 2014 and December 2015. The research question was: what are the offending, drug use, and mental health histories of Latinos involved in community corrections? Participants were mostly male (n = 120; 59.7%), White (n = 105; 52.2%), and Cuban (n = 97; 48.3%). U.S. born community corrections clients (n = 141) were more likely to report more lifetime and recent criminal activity; and more likely to report lifetime and recent drug use behavior than foreign-born Latinos (n = 60). No differences were found in recent mental health. Correctional healthcare should tailor services such as substance abuse treatment differently toward U.S. born and foreign-born Latinos.

  18. Neurological development of children born to mothers after kidney transplantation.

    Science.gov (United States)

    Schreiber-Zamora, Joanna; Szpotanska-Sikorska, Monika; Drozdowska-Szymczak, Agnieszka; Czaplinska, Natalia; Pietrzak, Bronisława; Wielgos, Miroslaw; Kociszewska-Najman, Bozena

    2017-12-03

    Pregnancies after kidney transplantation are at high risk of complications such as preterm birth and foetal growth restriction. Until now, the impact of these factors on neurological development of children born to transplant mothers has not been established. A comparison of neurological examinations performed in 36 children of kidney transplant women (study group) and 36 children born to healthy mothers (control group). The children from both groups were born at a similar gestational age and in the similar time period from 12/1996 to 09/2012. Neurological examinations were performed from 07/2010 to 11/2013. Each examination was adjusted to the patient's age and performed after the neonatal period. Three years later children were re-consulted, if they presented neurological deviations or were less than 12 months old at the time of the first examination. Normal neurological development was found in 86% of children in both groups (p = .999). Mild neurological deviations were observed in four (11%) children born to kidney transplant mothers and in five (14%) children born to healthy mothers (p = .999). Moderate deviations were diagnosed in one premature child born to transplant mother, whose pregnancy was complicated with a severe preeclampsia and foetal growth restriction. In the study population, no severe neurological disorders were found. Almost all (8/10) children with neurological deviations were born prematurely in good general conditions. The neurological deviations observed in the first year of life were mild and transient. In children over 1 year of age, deviations were more pronounced and continued to maintain. The neurological development of children of kidney transplant women is similar to that of the general population and possible deviations seem to be the result of intrauterine hypotrophy and prematurity. Therefore, in clinical practice, it is necessary to plan post-transplant pregnancies especially in women at high risk of these complications.

  19. Framatome ANP outage optimization support solutions

    International Nuclear Information System (INIS)

    Bombail, Jean Paul

    2003-01-01

    Over the last several years, leading plant operators have demonstrated that availability factors can be improved while safety and reliability can be enhanced on a long-term basis and operating costs reduced. Outage optimization is the new term being used to describe these long-term initiatives through which a variety of measures aimed at shortening scheduled plant outages have been developed and successfully implemented by these leaders working with their service providers who were introducing new technologies and process improvements. Following the leaders, all operators now have ambitious outage optimization plans and the median and average outage duration are decreasing world-wide. Future objectives are even more stringent and must include plant upgrades and component replacements being performed for life extension of plant operation. Outage optimization covers a broad range of activities from modifications of plant systems to faster cool down rates to human behavior improvements. It has been proven to reduce costs, avoid unplanned outages and thus support plant availability and help to ensure the utility's competitive position in the marketplace

  20. Atopic diseases in twins born after assisted reproduction.

    Science.gov (United States)

    Jäderberg, Ida; Thomsen, Simon F; Kyvik, Kirsten O; Skytthe, Axel; Backer, Vibeke

    2012-03-01

    We examined the risk of atopic diseases in twins born after assisted reproduction. Data on atopic diseases and assisted reproduction in 9694 twin pairs, 3-20 years of age, from the Danish Twin Registry were collected via multidisciplinary questionnaires. The risk of atopic diseases in twins born after assisted reproduction was compared with the risk in twins born after spontaneous conception using logistic regression and variance components analysis. Children born after assisted reproduction did not have a different risk of atopic outcomes (adjusted odds ratios [95% confidence intervals] for asthma: 0.95 [0.85, 1.07], P = 0.403; hay fever: 1.01 [0.86, 1.18], P = 0.918; and atopic dermatitis: 1.02 [0.81, 1.11], P = 0.773 respectively) compared with children born after spontaneous conception. Assisted reproduction did not modify the heritability of atopic diseases. This study does not support an association between assisted reproduction and development of atopic diseases. This result must be confirmed in subsequent studies, preferably of singleton populations. © 2011 Blackwell Publishing Ltd.

  1. Management of soil-borne diseases of organic vegetables

    Directory of Open Access Journals (Sweden)

    Shafique Hafiza Asma

    2016-07-01

    Full Text Available With the rising awareness of the adverse effects of chemical pesticides, people are looking for organically grown vegetables. Consumers are increasingly choosing organic foods due to the perception that they are healthier than those conventionally grown. Vegetable crops are vulnerable to a range of pathogenic organisms that reduce yield by killing the plant or damaging the product, thus making it unmarketable. Soil-borne diseases are among the major factors contributing to low yields of organic produce. Apart from chemical pesticides there are several methods that can be used to protect crops from soil-borne pathogens. These include the introduction of biocontrol agents against soil-borne plant pathogens, plants with therapeutic effects and organic soil amendments that stimulate antagonistic activities of microorganisms to soil-borne diseases. The decomposition of organic matter in soil also results in the accumulation of specific compounds that may be antifungal or nematicidal. With the growing interest in organic vegetables, it is necessary to find non chemical means of plant disease control. This review describes the impact of soil-borne diseases on organic vegetables and methods used for their control.

  2. Emerging arthropod-borne diseases of companion animals in Europe.

    Science.gov (United States)

    Beugnet, Frederic; Marié, Jean-Lou

    2009-08-26

    Vector-borne diseases are caused by parasites, bacteria or viruses transmitted by the bite of hematophagous arthropods (mainly ticks and mosquitoes). The past few years have seen the emergence of new diseases, or re-emergence of existing ones, usually with changes in their epidemiology (i.e. geographical distribution, prevalence, and pathogenicity). The frequency of some vector-borne diseases of pets is increasing in Europe, i.e. canine babesiosis, granulocytic anaplasmosis, canine monocytic ehrlichiosis, thrombocytic anaplasmosis, and leishmaniosis. Except for the last, these diseases are transmitted by ticks. Both the distribution and abundance of the three main tick species, Rhipicephalus sanguineus, Dermacentor reticulatus and Ixodes ricinus are changing. The conditions for such changes involve primarily human factors, such as travel with pets, changes in human habitats, social and leisure activities, but climate changes also have a direct impact on arthropod vectors (abundance, geographical distribution, and vectorial capacity). Besides the most known diseases, attention should be kept on tick-borne encephalitis, which seems to be increasing in western Europe, as well as flea-borne diseases like the flea-transmitted rickettsiosis. Here, after consideration of the main reasons for changes in tick vector ecology, an overview of each "emerging" vector-borne diseases of pets is presented.

  3. Growth and development in children born very low birthweight.

    Science.gov (United States)

    Scharf, Rebecca J; Stroustrup, Annemarie; Conaway, Mark R; DeBoer, Mark D

    2016-09-01

    To examine the relationships between growth (birth to age 2 years) and developmental outcomes in children born with very low birthweight (VLBW). Motor and mental development in children born with VLBW were regressed on anthropometric measurements at birth, 9 months and 2 years using multivariable regression. The Early Childhood Longitudinal Study-Birth Cohort, a longitudinal cohort, community sample, designed to be representative of children born across the USA. 950 children born with VLBW (children exhibited poor growth, with length-for-age z-scores children at 9 months (adjusted for prematurity) and 34.2% of children at 2 years. Compared with children having z-scores >-2, children with growth shortfalls in head circumference, length and weight had a higher adjusted OR (aOR) of low Bayley motor scores at 9 months and 2 years (aOR ranging from 1.8 to 3.3, all pchildren born with VLBW. While careful length measures may be a particularly useful marker, deficits in all anthropometric measures were risk factors for developmental delays. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  4. A surprise in the first Born approximation for electron scattering

    International Nuclear Information System (INIS)

    Treacy, M.M.J.; Van Dyck, D.

    2012-01-01

    A standard textbook derivation for the scattering of electrons by a weak potential under the first Born approximation suggests that the far-field scattered wave should be in phase with the incident wave. However, it is well known that waves scattered from a weak phase object should be phase-shifted by π/2 relative to the incident wave. A disturbing consequence of this missing phase is that, according to the Optical Theorem, the total scattering cross section would be zero in the first Born approximation. We resolve this mystery pedagogically by showing that the first Born approximation fails to conserve electrons even to first order. Modifying the derivation to conserve electrons introduces the correct phase without changing the scattering amplitude. We also show that the far-field expansion for the scattered waves used in many texts is inappropriate for computing an exit wave from a sample, and that the near-field expansion also give the appropriately phase-shifted result. -- Highlights: ► The first Born approximation is usually invoked as the theoretical physical basis for kinematical electron scattering theory. ► Although it predicts the correct scattering amplitude, it predicts the wrong phase; the scattered wave is missing a prefactor of i. ► We show that this arises because the standard textbook version of the first Born approximation does not conserve electrons. ► We show how this can be fixed.

  5. Social development of children born very preterm: a systematic review.

    Science.gov (United States)

    Ritchie, Kirsten; Bora, Samudragupta; Woodward, Lianne J

    2015-10-01

    To review systematically studies examining the development of social competence in children born very preterm (VPT) (gestation skills. Twenty-three studies were included. Seven focused on social competence and another 16 examined social competence within a range of outcomes. Study quality was low. Limitations included reliance on single informant data, cross-sectional measurement, use of brief screening tools, absence of child or peer report, and no conceptual model. In terms of social adjustment, 16 out of 21 studies found children born VPT had more peer problems and social withdrawal. Findings of social performance were mixed, with some studies suggesting differences in prosocial behavior (4/14) and others not. Social skills were assessed in four studies and showed children born VPT had poorer skills than children born at term. Predictors of social competence included gestational age, neonatal brain abnormalities, and family socio-economic status. Children born VPT have poorer social competence. These difficulties emerge early and persist throughout childhood. © 2015 Mac Keith Press.

  6. Topologically nontrivial black holes in Lovelock-Born-Infeld gravity

    Science.gov (United States)

    Farhangkhah, N.

    2018-04-01

    We present the black hole solutions possessing horizon with nonconstant-curvature and additional scalar restrictions on the base manifold in Lovelock gravity coupled to Born-Infeld (BI) nonlinear electrodynamics. The asymptotic and near origin behavior of the metric is presented and we analyze different behaviors of the singularity. We find that, in contrast to the case of black hole solutions of BI-Lovelock gravity with constant curvature horizon and Maxwell-Lovelock gravity with non constant horizon which have only timelike singularities, spacelike, and timelike singularities may exist for BI-Lovelock black holes with nonconstant curvature horizon. By calculating the thermodynamic quantities, we study the effects of nonlinear electrodynamics via the Born-Infeld action. Stability analysis shows that black holes with positive sectional curvature, κ , possess an intermediate unstable phase and large and small black holes are stable. We see that while Ricci flat Lovelock-Born-Infeld black holes having exotic horizons are stable in the presence of Maxwell field or either Born Infeld field with large born Infeld parameter β , unstable phase appears for smaller values of β , and therefore nonlinearity brings in the instability.

  7. Born Too Soon: Accelerating actions for prevention and care of 15 million newborns born too soon

    Science.gov (United States)

    2013-01-01

    Preterm birth complication is the leading cause of neonatal death resulting in over one million deaths each year of the 15 million babies born preterm. To accelerate change, we provide an overview of the comprehensive strategy required, the tools available for context-specific health system implementation now, and the priorities for research and innovation. There is an urgent need for action on a dual track: (1) through strategic research to advance the prevention of preterm birth and (2) improved implementation and innovation for care of the premature neonate. We highlight evidence-based interventions along the continuum of care, noting gaps in coverage, quality, equity and implications for integration and scale up. Improved metrics are critical for both burden and tracking programmatic change. Linked to the United Nation's Every Women Every Child strategy, a target was set for 50% reduction in preterm deaths by 2025. Three analyses informed this target: historical change in high income countries, recent progress in best performing countries, and modelling of mortality reduction with high coverage of existing interventions. If universal coverage of selected interventions were to be achieved, then 84% or more than 921,000 preterm neonatal deaths could be prevented annually, with antenatal corticosteroids and Kangaroo Mother Care having the highest impact. Everyone has a role to play in reaching this target including government leaders, professionals, private sector, and of course families who are affected the most and whose voices have been critical for change in many of the countries with the most progress. Declaration This article is part of a supplement jointly funded by Save the Children's Saving Newborn Lives programme through a grant from The Bill & Melinda Gates Foundation and March of Dimes Foundation and published in collaboration with the Partnership for Maternal, Newborn and Child Health and the World Health Organization (WHO). The original article was

  8. 8 CFR 289.3 - Recording the entry of certain American Indians born in Canada.

    Science.gov (United States)

    2010-01-01

    ... Indians born in Canada. 289.3 Section 289.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS AMERICAN INDIANS BORN IN CANADA § 289.3 Recording the entry of certain American Indians born in Canada. The lawful admission for permanent residence of an American Indian born in Canada...

  9. Black hole solutions in mimetic Born-Infeld gravity

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Che-Yu [National Taiwan University, Department of Physics and Center for Theoretical Sciences, Taipei (China); LeCosPA, National Taiwan University, Taipei (China); Bouhmadi-Lopez, Mariam [University of the Basque Country UPV/EHU, Department of Theoretical Physics, Bilbao (Spain); IKERBASQUE, Basque Foundation for Science, Bilbao (Spain); Chen, Pisin [National Taiwan University, Department of Physics and Center for Theoretical Sciences, Taipei (China); LeCosPA, National Taiwan University, Taipei (China); Stanford University, Kavli Institute for Particle Astrophysics and Cosmology, SLAC National Accelerator Laboratory, Stanford, CA (United States)

    2018-01-15

    The vacuum, static, and spherically symmetric solutions in the mimetic Born-Infeld gravity are studied. The mimetic Born-Infeld gravity is a reformulation of the Eddington-inspired-Born-Infeld (EiBI) model under the mimetic approach. Due to the mimetic field, the theory contains non-trivial vacuum solutions different from those in Einstein gravity. We find that with the existence of the mimetic field, the spacelike singularity inside a Schwarzschild black hole could be altered to a lightlike singularity, even though the curvature invariants still diverge at the singularity. Furthermore, in this case, the maximal proper time for a timelike radially-infalling observer to reach the singularity is found to be infinite. (orig.)

  10. Heat engines for dilatonic Born-Infeld black holes

    Energy Technology Data Exchange (ETDEWEB)

    Bhamidipati, Chandrasekhar; Yerra, Pavan Kumar [Indian Institute of Technology Bhubaneswar, School of Basic Sciences, Bhubaneswar (India)

    2017-08-15

    In the context of dilaton coupled Einstein gravity with a negative cosmological constant and a Born-Infeld field, we study heat engines where a charged black hole is the working substance. Using the existence of a notion of thermodynamic mass and volume (which depend on the dilaton coupling), the mechanical work takes place via the pdV terms present in the first law of extended gravitational thermodynamics. The efficiency is analyzed as a function of dilaton and Born-Infeld couplings, and the results are compared with analogous computations in the related conformal solutions in the Brans-Dicke-Born-Infeld theory and black holes in anti-de Sitter space-time. (orig.)

  11. Black hole solutions in mimetic Born-Infeld gravity.

    Science.gov (United States)

    Chen, Che-Yu; Bouhmadi-López, Mariam; Chen, Pisin

    2018-01-01

    The vacuum, static, and spherically symmetric solutions in the mimetic Born-Infeld gravity are studied. The mimetic Born-Infeld gravity is a reformulation of the Eddington-inspired-Born-Infeld (EiBI) model under the mimetic approach. Due to the mimetic field, the theory contains non-trivial vacuum solutions different from those in Einstein gravity. We find that with the existence of the mimetic field, the spacelike singularity inside a Schwarzschild black hole could be altered to a lightlike singularity, even though the curvature invariants still diverge at the singularity. Furthermore, in this case, the maximal proper time for a timelike radially-infalling observer to reach the singularity is found to be infinite.

  12. Developmental delay at 12 months in children born extremely preterm

    DEFF Research Database (Denmark)

    Lando, Ane; Klamer, Anja; Jonsbo, Finn

    2005-01-01

    AIM: To evaluate the feasibility and validity of a structured telephone interview to assess the development of children born extremely preterm. METHODS: The parents of 88 children born with a gestational age below 28 wk admitted to the neonatal intensive care unit (NICU) at Rigshospitalet......, Copenhagen, were interviewed by telephone when their child was 1 y of age, corrected for preterm birth. A fully structured questionnaire on psychomotor function was used (Revised Prescreening Developmental Questionnaire (R-PDQ)). The parents of 30 children born at term without complications were interviewed...... to use by staff and well accepted by parents. The mean score in the preterm group was 14.9+/-3.9 vs 17.7+/-2.7 in the term group (pchildren had developmental scores below-2 SD. The R-PDQ score was associated with the ASQ score 2 y later. CONCLUSION: A structured questionnaire administrated...

  13. The Born-Mayer-Huggins potential in high temperature superconductors

    Science.gov (United States)

    Singh, Hempal; Singh, Anu; Indu, B. D.

    2016-07-01

    The Born-Mayer-Huggins potential which has been found the best suitable potential to study the YBa2Cu3O7-δ type high temperature superconductors is revisited in a new framework. A deeper insight in it reveals that the Born-Mayer parameters for different interactions in high temperature superconductor are not simple quantities but several thermodynamic and spatial functions enter the problem. Based on the new theory, the expressions for pressure, bulk modulus and Born-Mayer parameters have been derived and it is established that these quantities depend upon Gruneisen parameter which is the measure of the strength of anharmonic effects in high temperature superconductors. This theory has been applied to a specific model YBa2Cu3O7-δ crystal for the purpose of numerical estimates to justify the new results.

  14. Born Globals - Is there Fire Behind the Smoke?

    DEFF Research Database (Denmark)

    Choquette, Eliane; Rask, Morten; Sala, Davide

    2017-01-01

    the first detailed account of Born Globals compared to proper control groups of other start-ups. Chiefly we investigate firm performance, which in turn permits interference on socioeconomic impact. We find that the occurrence of BGs is not specific to certain sectors, nor does their frequency change......Are Born Globals really different from firms with other start-up histories? We address this question based on a unique longitudinal data set that tracks all Danish manufacturing start-ups founded between 1994 and 2008 (23,201 firms). This novel application of register data allows us to provide...... in light of rapid ICT progress. However, we find that Born Globals have significantly higher turnover and employment levels as well as job growth rates. Moreover, they show a considerably wider market reach, but little to no productivity advantage compared to firms with less or later internationalization...

  15. Born reciprocity in string theory and the nature of spacetime

    Energy Technology Data Exchange (ETDEWEB)

    Freidel, Laurent, E-mail: lfreidel@perimeterinstitute.ca [Perimeter Institute for Theoretical Physics, 31 Caroline St., N, Ontario N2L 2Y5, Waterloo (Canada); Leigh, Robert G., E-mail: rgleigh@uiuc.edu [Department of Physics, University of Illinois, 1110 West Green St., Urbana, IL 61801 (United States); Minic, Djordje, E-mail: dminic@vt.edu [Department of Physics, Virginia Tech, Blacksburg, VA 24061 (United States)

    2014-03-07

    After many years, the deep nature of spacetime in string theory remains an enigma. In this Letter we incorporate the concept of Born reciprocity in order to provide a new point of view on string theory in which spacetime is a derived dynamical concept. This viewpoint may be thought of as a dynamical chiral phase space formulation of string theory, in which Born reciprocity is implemented as a choice of a Lagrangian submanifold of the phase space, and amounts to a generalization of T-duality. In this approach the fundamental symmetry of string theory contains phase space diffeomorphism invariance and the underlying string geometry should be understood in terms of dynamical bi-Lagrangian manifolds and an apparently new geometric structure, somewhat reminiscent of para-quaternionic geometry, which we call Born geometry.

  16. Born reciprocity in string theory and the nature of spacetime

    International Nuclear Information System (INIS)

    Freidel, Laurent; Leigh, Robert G.; Minic, Djordje

    2014-01-01

    After many years, the deep nature of spacetime in string theory remains an enigma. In this Letter we incorporate the concept of Born reciprocity in order to provide a new point of view on string theory in which spacetime is a derived dynamical concept. This viewpoint may be thought of as a dynamical chiral phase space formulation of string theory, in which Born reciprocity is implemented as a choice of a Lagrangian submanifold of the phase space, and amounts to a generalization of T-duality. In this approach the fundamental symmetry of string theory contains phase space diffeomorphism invariance and the underlying string geometry should be understood in terms of dynamical bi-Lagrangian manifolds and an apparently new geometric structure, somewhat reminiscent of para-quaternionic geometry, which we call Born geometry.

  17. Oral health of children born small for gestational age.

    LENUS (Irish Health Repository)

    O'Connell, A C

    2010-10-01

    We sought to evaluate the oral health status of children born small for gestational age (SGA). Children now aged 4-8 years who were born SGA (birth weight < -2 SDS) were examined using standardised criteria. The parents completed a structured oral health questionnaire. Twenty females and 25 males, mean age 72.1 months, and mean birth weight 2.1 kg, participated in the study. Poor appetite was a concern; 32 (71%) children snacked between meals and 14 (30%) used carbonated beverages more than 3 times daily. Erosion was present in 9 (20%) children. Dental decay occurred in 22 (47%) children with 92% being untreated. Eight children had more than 5 decayed teeth. It is essential that clinicians working with children born SGA include oral health within the general health surveillance and refer these children for a dental assessment within the first 2 years to support parents in establishing safe feeding patterns for their children.

  18. Work Disability Among Native-born and Foreign-born Americans: On Origins, Health, and Social Safety Nets.

    Science.gov (United States)

    Engelman, Michal; Kestenbaum, Bert M; Zuelsdorff, Megan L; Mehta, Neil K; Lauderdale, Diane S

    2017-12-01

    Public debates about both immigration policy and social safety net programs are increasingly contentious. However, little research has explored differences in health within America's diverse population of foreign-born workers, and the effect of these workers on public benefit programs is not well understood. We investigate differences in work disability by nativity and origins and describe the mix of health problems associated with receiving Social Security Disability Insurance benefits. Our analysis draws on two large national data sources-the American Community Survey and comprehensive administrative records from the Social Security Administration-to determine the prevalence and incidence of work disability between 2001 and 2010. In sharp contrast to prior research, we find that foreign-born adults are substantially less likely than native-born Americans to report work disability, to be insured for work disability benefits, and to apply for those benefits. Overall and across origins, the foreign-born also have a lower incidence of disability benefit award. Persons from Africa, Northern Europe, Canada, and parts of Asia have the lowest work disability benefit prevalence rates among the foreign-born; persons from Southern Europe, Western Europe, the former Soviet Union, and the Caribbean have the highest rates.

  19. A local network integrated into a balloon-borne apparatus

    Science.gov (United States)

    Imori, Masatosi; Ueda, Ikuo; Shimamura, Kotaro; Maeno, Tadashi; Murata, Takahiro; Sasaki, Makoto; Matsunaga, Hiroyuki; Matsumoto, Hiroshi; Shikaze, Yoshiaki; Anraku, Kazuaki; Matsui, Nagataka; Yamagami, Takamasa

    A local network is incorporated into an apparatus for a balloon-borne experiment. A balloon-borne system implemented in the apparatus is composed of subsystems interconnected through a local network, which introduces modular architecture into the system. The network decomposes the balloon-borne system into subsystems, which are similarly structured from the point of view that the systems is kept under the control of a ground station. The subsystem is functionally self-contained and electrically independent. A computer is integrated into a subsystem, keeping the subsystem under the control. An independent group of batteries, being dedicated to a subsystem, supplies the whole electricity of the subsystem. The subsystem could be turned on and off independently of the other subsystems. So communication among the subsystems needs to be based on such a protocol that could guarantee the independence of the individual subsystems. An Omninet protocol is employed to network the subsystems. A ground station sends commands to the balloon-borne system. The command is received and executed at the system, then results of the execution are returned to the ground station. Various commands are available so that the system borne on a balloon could be controlled and monitored remotely from the ground station. A subsystem responds to a specific group of commands. A command is received by a transceiver subsystem and then transferred through the network to the subsystem to which the command is addressed. Then the subsystem executes the command and returns results to the transceiver subsystem, where the results are telemetered to the ground station. The network enhances independence of the individual subsystems, which enables programs of the individual subsystems to be coded independently. Independence facilitates development and debugging of programs, improving the quality of the system borne on a balloon.

  20. Emerging vector borne diseases – incidence through vectors

    Directory of Open Access Journals (Sweden)

    Sara eSavic

    2014-12-01

    Full Text Available Vector borne diseases use to be a major public health concern only in tropical and subtropical areas, but today they are an emerging threat for the continental and developed countries also. Nowdays, in intercontinetal countries, there is a struggle with emerging diseases which have found their way to appear through vectors. Vector borne zoonotic diseases occur when vectors, animal hosts, climate conditions, pathogens and susceptible human population exist at the same time, at the same place. Global climate change is predicted to lead to an increase in vector borne infectious diseases and disease outbreaks. It could affect the range and popultion of pathogens, host and vectors, transmission season, etc. Reliable surveilance for diseases that are most likely to emerge is required. Canine vector borne diseases represent a complex group of diseases including anaplasmosis, babesiosis, bartonellosis, borreliosis, dirofilariosis, erlichiosis, leishmaniosis. Some of these diseases cause serious clinical symptoms in dogs and some of them have a zoonotic potential with an effect to public health. It is expected from veterinarians in coordination with medical doctors to play a fudamental role at primeraly prevention and then treatment of vector borne diseases in dogs. The One Health concept has to be integrated into the struggle against emerging diseases.During a four year period, from 2009-2013, a total number of 551 dog samples were analysed for vector borne diseases (borreliosis, babesiosis, erlichiosis, anaplasmosis, dirofilariosis and leishmaniasis in routine laboratory work. The analysis were done by serological tests – ELISA for borreliosis, dirofilariosis and leishmaniasis, modified Knott test for dirofilariosis and blood smear for babesiosis, erlichiosis and anaplasmosis. This number of samples represented 75% of total number of samples that were sent for analysis for different diseases in dogs. Annually, on avarege more then half of the samples

  1. Mathematics ability and related skills in preschoolers born very preterm.

    Science.gov (United States)

    Hasler, Holly M; Akshoomoff, Natacha

    2017-12-12

    Children born very preterm (VPT) are at risk for academic, behavioral, and/or emotional problems. Mathematics is a particular weakness and better understanding of the relationship between preterm birth and early mathematics ability is needed, particularly as early as possible to aid in early intervention. Preschoolers born VPT (n = 58) and those born full term (FT; n = 29) were administered a large battery of measures within 6 months of beginning kindergarten. A multiple-mediation model was utilized to characterize the difference in skills underlying mathematics ability between groups. Children born VPT performed significantly worse than FT-born children on a measure of mathematics ability as well as full-scale IQ, verbal skills, visual-motor integration, phonological awareness, phonological working memory, motor skills, and executive functioning. Mathematics was significantly correlated with verbal skills, visual-motor integration, phonological processing, and motor skills across both groups. When entered into the mediation model, verbal skills, visual-motor integration, and phonological awareness were significant mediators of the group differences. This analysis provides insights into the pre-academic skills that are weak in preschoolers born VPT and their relationship to mathematics. It is important to identify children who will have difficulties as early as possible, particularly for VPT children who are at higher risk for academic difficulties. Therefore, this model may be used in evaluating VPT children for emerging difficulties as well as an indicator that if other weaknesses are found, an assessment of mathematics should be conducted.

  2. Impact of climate trends on tick-borne pathogen transmission

    Directory of Open Access Journals (Sweden)

    Agustin eEstrada-Pena

    2012-03-01

    Full Text Available Recent advances in climate research together with a better understanding of tick-pathogen interactions, the distribution of ticks and the diagnosis of tick-borne pathogens raise questions about the impact of environmental factors on tick abundance and spread and the prevalence and transmission of tick-borne pathogens. While undoubtedly climate plays a role in the changes in distribution and seasonal abundance of ticks, it is always difficult to disentangle factors impacting on the abundance of tick hosts from those exerted by human habits. All together, climate, host abundance and social factors may explain the upsurge of epidemics transmitted by ticks to humans. Herein we focused on tick-borne pathogens that affect humans with pandemic potential. Borrelia burgdorferi s.l. (Lyme disease, Anaplasma phagocytophilum (human granulocytic anaplasmosis and tick-borne encephalitis virus (tick-borne encephalitis are transmitted by Ixodes spp. Crimean-Congo hemorrhagic fever virus (Crimean-Congo hemorrhagic fever is transmitted by Hyalomma spp. In this review, we discussed how vector tick species occupy the habitat as a function of different climatic factors, and how these factors impact on tick survival and seasonality. How molecular events at the tick-pathogen interface impact on pathogen transmission is also discussed. Results from statistically and biologically derived models are compared to show that while statistical models are able to outline basic information about tick distributions, biologically derived models are necessary to evaluate pathogen transmission rates and understand the effect of climatic variables and host abundance patterns on pathogen transmission. The results of these studies could be used to build early alert systems able to identify the main factors driving the subtle changes in tick distribution and seasonality and the prevalence of tick-borne pathogens.

  3. Exploring workplace TB interventions with foreign-born Latino workers.

    Science.gov (United States)

    Eggerth, Donald E; Keller, Brenna M; Flynn, Michael A

    2018-05-15

    Persons born outside the United States are more likely to be diagnosed with tuberculosis disease (TB) than native-born individuals. Foreign-born Latinos at risk of TB may be difficult to reach with public health interventions due to cultural and institutional barriers. Workplaces employing large concentrations of foreign-born Latinos may be useful locations for TB interventions targeting this high-risk population. This study used a two-phase approach to investigate the feasibility of workplace TB interventions. The first phase investigated employer knowledge of TB and receptiveness to allowing TB interventions in their businesses through 5 structured interviews. The second phase investigated foreign-born workers' knowledge of TB and their receptiveness to receiving TB interventions in their places of employment through 12 focus groups stratified by gender and education. Phase 1: Only 1 of the 5 employers interviewed had a high level of knowledge about TB, and three had no knowledge other than that TB was a disease that involved coughing. They were receptive to workplace TB interventions, but were concerned about lost productivity and customers finding out if an employee had TB. Phase 2: There was no observed differences in responses between gender and between the bottom two education groups, so the final analysis took place between a gender-combined lower education group and higher education group. The higher education group tended to have knowledge that was more accurate and to view TB as a disease associated with poverty. The lower education group tended to have more misconceptions about TB and more often expressed concern that their employers would not support worksite interventions. The results from both phases indicate that more TB education is needed among both foreign-born Latino workers and their employers. Obstacles to implementing workplace TB interventions include knowledge, potential productivity loss, employer liability, and perceived customer response

  4. Generalized Born-Infeld actions and projective cubic curves

    Energy Technology Data Exchange (ETDEWEB)

    Ferrara, S. [Department of Physics, CERN Theory Division, CH - 1211 Geneva 23 (Switzerland); INFN - Laboratori Nazionali di Frascati, Via Enrico Fermi 40, I-00044, Frascati (Italy); Porrati, M. [CCPP, Department of Physics, NYU, 4 Washington Pl., New York, NY, 10003 (United States); Sagnotti, A. [Department of Physics, CERN Theory Division, CH - 1211 Geneva 23 (Switzerland); Stora, R. [Department of Physics, CERN Theory Division, CH - 1211 Geneva 23 (Switzerland); Laboratoire d' Annecy-le-Vieux de Physique Theorique (LAPTH), F-74941, Annecy-le-Vieux, Cedex (France); Yeranyan, A. [INFN - Laboratori Nazionali di Frascati, Via Enrico Fermi 40, I-00044, Frascati (Italy); Centro Studi e Ricerche Enrico Fermi, Via Panisperna 89A, 00184, Roma (Italy)

    2015-04-01

    We investigate U(1){sup n} supersymmetric Born-Infeld Lagrangians with a second non-linearly realized supersymmetry. The resulting non-linear structure is more complex than the square root present in the standard Born-Infeld action, and nonetheless the quadratic constraints determining these models can be solved exactly in all cases containing three vector multiplets. The corresponding models are classified by cubic holomorphic prepotentials. Their symmetry structures are associated to projective cubic varieties. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  5. Tick Talk: Tick-borne Diseases of South Dakota.

    Science.gov (United States)

    Huntington, Mark K; Allison, Jay

    2017-09-01

    In addition to being a nuisance, ticks can carry disease. This article presents a brief review of ticks and associated tick-borne disease relevant to South Dakota and surrounding regions. Tick-borne diseases of special relevance in South Dakota include tularemia, Rocky Mountain spotted fever, and Lyme disease. A number of others may also be encountered in the state as well. Prompt treatment of suspected cases is important to ensure a successful recovery, and tick-avoidance measures can reduce the risks of acquiring them. Most of these conditions are nationally reportable infectious diseases. Copyright© South Dakota State Medical Association.

  6. Born amplitudes and seagull term in meson-soliton scattering

    International Nuclear Information System (INIS)

    Liang, Y.G.; Li, B.A.; Liu, K.F.; Su, R.K.

    1990-01-01

    The meson-soliton scattering for the φ 4 theory in 1+1 dimensions is calculated. We show that when the seagull term from the equal time commutator is included in addition to the Born amplitudes, the t-matrix from the reduction formula approach is identical to that of the potential scattering with small quantum fluctuations to leading order in weak coupling. The seagull term is equal to the Born term in the potential scattering. This confirms the speculation that the leading order Yukawa coupling is derivable from the classical soliton. (orig.)

  7. Exact solutions of Lovelock-Born-Infeld black holes

    International Nuclear Information System (INIS)

    Aiello, Matias; Ferraro, Rafael; Giribet, Gaston

    2004-01-01

    The exact five-dimensional charged black hole solution in Lovelock gravity coupled to Born-Infeld electrodynamics is presented. This solution interpolates between the Hoffmann black hole for the Einstein-Born-Infeld theory and other solutions in the Lovelock theory previously studied in the literature. It is shown how the conical singularity of the metric around the origin can be removed by a proper choice of the black hole parameters. The differences existing with the Reissner-Nordstroem black holes are discussed. In particular, we show the existence of charged black holes with a unique horizon

  8. Energy conserving, linear scaling Born-Oppenheimer molecular dynamics.

    Science.gov (United States)

    Cawkwell, M J; Niklasson, Anders M N

    2012-10-07

    Born-Oppenheimer molecular dynamics simulations with long-term conservation of the total energy and a computational cost that scales linearly with system size have been obtained simultaneously. Linear scaling with a low pre-factor is achieved using density matrix purification with sparse matrix algebra and a numerical threshold on matrix elements. The extended Lagrangian Born-Oppenheimer molecular dynamics formalism [A. M. N. Niklasson, Phys. Rev. Lett. 100, 123004 (2008)] yields microcanonical trajectories with the approximate forces obtained from the linear scaling method that exhibit no systematic drift over hundreds of picoseconds and which are indistinguishable from trajectories computed using exact forces.

  9. Emerging Vector-Borne Diseases - Incidence through Vectors.

    Science.gov (United States)

    Savić, Sara; Vidić, Branka; Grgić, Zivoslav; Potkonjak, Aleksandar; Spasojevic, Ljubica

    2014-01-01

    Vector-borne diseases use to be a major public health concern only in tropical and subtropical areas, but today they are an emerging threat for the continental and developed countries also. Nowadays, in intercontinental countries, there is a struggle with emerging diseases, which have found their way to appear through vectors. Vector-borne zoonotic diseases occur when vectors, animal hosts, climate conditions, pathogens, and susceptible human population exist at the same time, at the same place. Global climate change is predicted to lead to an increase in vector-borne infectious diseases and disease outbreaks. It could affect the range and population of pathogens, host and vectors, transmission season, etc. Reliable surveillance for diseases that are most likely to emerge is required. Canine vector-borne diseases represent a complex group of diseases including anaplasmosis, babesiosis, bartonellosis, borreliosis, dirofilariosis, ehrlichiosis, and leishmaniosis. Some of these diseases cause serious clinical symptoms in dogs and some of them have a zoonotic potential with an effect to public health. It is expected from veterinarians in coordination with medical doctors to play a fundamental role at primarily prevention and then treatment of vector-borne diseases in dogs. The One Health concept has to be integrated into the struggle against emerging diseases. During a 4-year period, from 2009 to 2013, a total number of 551 dog samples were analyzed for vector-borne diseases (borreliosis, babesiosis, ehrlichiosis, anaplasmosis, dirofilariosis, and leishmaniasis) in routine laboratory work. The analysis was done by serological tests - ELISA for borreliosis, dirofilariosis, and leishmaniasis, modified Knott test for dirofilariosis, and blood smear for babesiosis, ehrlichiosis, and anaplasmosis. This number of samples represented 75% of total number of samples that were sent for analysis for different diseases in dogs. Annually, on average more then half of the samples

  10. The Alliance Capability of Technology-Based Born Globals

    DEFF Research Database (Denmark)

    Oxtorp, Liliya Altshuler; Elg, Ulf

    2015-01-01

    A detailed investigation of the aspects comprising the alliance capability of technology-based born globals. Alliance capability is regarded as a set of organizational skills necessary from the decision to search for a partner for a technology collaboration, which may also involve a marketing...... and risks of collaborating with MNEs.Methodology: A longitudinal process study of a Danish technology born global with three embedded cases of its R&D and marketing alliances with Asian MNEs.Findings: The organisational skills comprising the alliance capability are defined to be internal and external...

  11. Quality of Cancer Care Among Foreign-Born and US-Born Patients With Lung or Colorectal Cancer

    DEFF Research Database (Denmark)

    Nielsen, Signe Smith; He, Yulei; Ayanian, John Z.

    2010-01-01

      BACKGROUND: Disparities in care have been documented for foreign-born cancer patients in the United States. However, few data are available regarding patients with lung and colorectal cancer. In the current study, the authors assessed whether patient-reported quality and receipt of recommended...... from 2003 through 2005. Logistic regression was used to assess the association between nativity and patient-reported quality of care and receipt of recommended treatments (adjuvant chemotherapy for stage III colon cancer, adjuvant chemotherapy and radiotherapy for stage II/III rectal cancer......, and curative surgery for stage I/II non-small cell lung cancer). The authors also assessed whether language explained any differences in care by nativity. RESULTS: Overall, 46% of patients reported excellent care, but foreign-born patients were less likely than US-born patients to report excellent quality...

  12. HIV and sexual health knowledge and sexual experience among Australian-born and overseas-born students in Sydney.

    Science.gov (United States)

    Song, Angela; Richters, Juliet; Crawford, June; Kippax, Sue

    2005-09-01

    To examine differences between Australian-born and Asian-born first-year university students in Sydney in their sexual behavior and knowledge about the prevention and transmission of human immunodeficiency virus (HIV) and other sexually transmissible infections (STIs). Students were recruited from a stall during the student Orientation Week in both 2002 and 2003 at the University of New South Wales. A short questionnaire was completed and returned anonymously. Data on age, gender, country of birth, sexual behavior, and sexual health knowledge were collected. A score was calculated based on the sum of the correct answers given to 12 HIV/STI transmission and prevention questions. The students were then divided into three groups according to their country of birth (Australia, Asia, and elsewhere) and their knowledge scores were compared. Students born in certain Asian countries were also asked their perception of the HIV epidemic in their home country compared with Australia. A total of 1185 first-year students completed the questionnaire. Although older on average, Asian-born students were less likely to have had sexual intercourse and had had fewer sexual partners. They also had consistently poorer HIV/STI knowledge scores than Australian-born students. Students born in China, Hong Kong, Indonesia, Malaysia, and Singapore but not Thailand underestimated the prevalence of HIV in their country of birth in comparison with Australia. The combination of poorer knowledge, apparent misconception of the extent of HIV epidemic in their home country (or Australia), and potential later frequent travel indicates a potential risk for later transmission of HIV/STIs. The university is an underused setting for prevention health education.

  13. Quality Determination of Pipe-Borne Water in Sokoto Metropolis ...

    African Journals Online (AJOL)

    The quality of the pipe-borne water supplied to Sokoto metropolis was determined in this study. The total bacterial count was carried out using surface plating method of inoculation. The coliforms were enumerated using multiple tube fermentation technique (Most Probable Number Method). Some physicochemical ...

  14. Optimal vaccination scenarios against vector-borne diseases

    DEFF Research Database (Denmark)

    Græsbøll, Kaare; Enøe, Claes; Bødker, Rene

    that would increase distance between infectious and susceptible hosts. This can be done very efficiently on a regional scale if the incursion route is well specified. However as the long-range spread of midge borne disease is still poorly quantified, more robust national vaccination schemes seems preferable...

  15. Detection of Seed-Borne Fungal pathogens on Soya beans

    International Nuclear Information System (INIS)

    Wanyera, R

    2002-01-01

    Soya beans (Glycine max max L.) are propagated by seed and are vulnerable to devastating seed-borne diseases where the importance of each disease varies greatly. Seed-borne diseases cause significant losses in seed, food production and quality of seed and grain. Studies on seed borne diseases in Kenya have not been given emphasis on very important seed crops among the soya beans. The identification and rejection of the seed crop is mainly based on visual appraisal in the field with little or no laboratory work undertaken. Three methods were used to analyse the health status of fifty two soyabean seed samples collected from the National Plant Breeding Research Centre-Njoro and farmers' fields in Bahati division of Nakuru district. The analysis was carried out in the laboratory. The objective of the analysis was to identify and inventory seed-borne fungal pathogens of soya beans grown in Kenya. The normal blotter, herbicide and germination test methods were used. The tests revealed the presence of several important fungal pathogens on soyabean seed samples. Among the pathogens recorded Phoma sp, phomopsis sp, fusarium sp, Hainesia lyhri and Cercospora kikuchii were frequently recorded on the seed samples. Results of the germination test between paper method showed low germination (0-6.7%) on the normal sedlings in all the test samples. Hainesia lyhri was a new record on the soyabean seeds

  16. Lung function and exercise capacity in young adults born prematurely

    NARCIS (Netherlands)

    Vrijlandt, EJLE; Gerritsen, J; Boezen, HM; Grevink, RG; Duiverman, EJ

    2006-01-01

    Rationale: Limited information is available about the long-term outcome of lung function and exercise capacity in young adults born prematurely. Objective: To determine long-term effects of prematurity on lung function (volumes, diffusing capacity) and exercise capacity in expreterms compared with

  17. Arthropod Borne Diseases in Imposed War during 1980-88

    Directory of Open Access Journals (Sweden)

    M Khoobdel

    2008-06-01

    Full Text Available Background: Personnel of military forces have close contact with natural habitat and usually encounter with bite of arthropods and prone to be infected with arthropod borne diseases. The imposed war against Iran was one of the most important and the longest war in the Middle East and even in the world and military people faced various diseases. The aim of this study was to review prevalence of arthropod borne diseases and to collect relevant information and valuable experiences during the imposed war.Methods: The present survey is a historical research and cross-sectional study, focused on arthropod fauna, situation of different arthropod borne diseases and also the ways which military personnel used to protect themselves against them. The information was adopted from valid military health files and also interviewing people who participated in the war.Results: Scabies, cutaneous leishmaniasis, sandfly fever and pediculosis were more prevalent among other arthropod -borne diseases in Iran-Iraq war. Measures to control arthropods and diseases at wartime mainly included: scheduled spraying of pesticides, leishmanization and treatment of patients.Conclusion: Although measures used during the war to control arthropods were proper, however, due to needs and importance of military forces to new equipment and technologies, it is recommended to use deltamethrin-impreg­nated bed net, permethrin treated military uniforms and various insect repellents in future.

  18. Arthropod Borne Diseases in Imposed War during 1980-88

    Directory of Open Access Journals (Sweden)

    M Khoobdel

    2008-08-01

    Full Text Available Background: Personnel of military forces have close contact with natural habitat and usually encounter with bite of arthropods and prone to be infected with arthropod borne diseases. The imposed war against Iran was one of the most important and the longest war in the Middle East and even in the world and military people faced various diseases. The aim of this study was to review prevalence of arthropod borne diseases and to collect relevant information and valuable experiences during the imposed war. Methods: The present survey is a historical research and cross-sectional study, focused on arthropod fauna, situation of different arthropod borne diseases and also the ways which military personnel used to protect themselves against them. The information was adopted from valid military health files and also interviewing people who participated in the war. Results: Scabies, cutaneous leishmaniasis, sandfly fever and pediculosis were more prevalent among other arthropod -borne diseases in Iran-Iraq war. Measures to control arthropods and diseases at wartime mainly included: scheduled spraying of pesticides, leishmanization and treatment of patients. Conclusion: Although measures used during the war to control arthropods were proper, however, due to needs and importance of military forces to new equipment and technologies, it is recommended to use deltamethrin-impreg­nated bed net, permethrin treated military uniforms and various insect repellents in future.

  19. The accidental internationalists : A theory of born globals

    NARCIS (Netherlands)

    Hennart, J.M.A.

    The distinguishing characteristic of international new ventures/born globals (INVs/BGs) is that they have foreign sales from the outset, or very quickly afterward. I argue that this is due to their business model. INVs/BGs sell to spatially dispersed customers distinctive niche products that incur

  20. R7 VU Born-Assessed Demo Plan

    Energy Technology Data Exchange (ETDEWEB)

    Robert Nourgaliev

    2010-02-01

    This is an initial draft of a born-assessed VU plan for the RELAP7 (R7) code development effort. The plan will continue to evolve based on the growth of code capability. This growth will be reflected as additional testing is identified and done. Later versions of this document will reflect that growth.

  1. International Pricing Strategies for Born-Global Firms

    Directory of Open Access Journals (Sweden)

    Michael Neubert

    2017-10-01

    Full Text Available This paper aims to understand how born global firms develop their international pricing strategies, practices, and models. It aims to expand the study of international entrepreneurship and born global firms by including a broader and deeper range of pricing aspects than is normally found in the international entrepreneurship and pricing literature. The paper opted for a multiple case-study research design using different sources of evidence, including four in-depth interviews with CEOs of born global firms. The case-study firms were selected using a purposive selection method. The theoretical framework of Ingenbleek, Frambach & Verhallen is used. The results suggest that successful leaders act as ‘integrating forces’ on two levels: by applying a structured and disciplined price-setting process with regular reviews and by mediating between corporate financial goals and the local market reality. The results support the claim that policy makers should offer insights, training and financial support to give promising born global firms the possibility to select the most efficient international pricing models and strategies. The results are relevant for entrepreneurs to understand the importance of efficient price-modelling processes and the influence of the different price strategies and price models on financial results and sales revenues.

  2. The regular cosmic string in Born-Infeld gravity

    Energy Technology Data Exchange (ETDEWEB)

    Ferraro, Rafael; Fiorini, Franco, E-mail: ferraro@iafe.uba.ar, E-mail: franco@iafe.uba.ar [Instituto de AstronomIa y Fisica del Espacio, Casilla de Correo 67, Sucursal 28, 1428 Buenos Aires (Argentina)

    2011-09-22

    It is shown that Born-Infeld gravity -a high energy deformation of Einstein gravity-removes the singularities of a cosmic string. The respective vacuum solution results to be free of conical singularity and closed timelike curves. The space ends at a minimal circle where the curvature invariants vanish; but this circle cannot be reached in a finite proper time.

  3. Genetic Characterization of the Tick-Borne Orbiviruses

    Directory of Open Access Journals (Sweden)

    Manjunatha N. Belaganahalli

    2015-04-01

    Full Text Available The International Committee for Taxonomy of Viruses (ICTV recognizes four species of tick-borne orbiviruses (TBOs: Chenuda virus, Chobar Gorge virus, Wad Medani virus and Great Island virus (genus Orbivirus, family Reoviridae. Nucleotide (nt and amino acid (aa sequence comparisons provide a basis for orbivirus detection and classification, however full genome sequence data were only available for the Great Island virus species. We report representative genome-sequences for the three other TBO species (virus isolates: Chenuda virus (CNUV; Chobar Gorge virus (CGV and Wad Medani virus (WMV. Phylogenetic comparisons show that TBOs cluster separately from insect-borne orbiviruses (IBOs. CNUV, CGV, WMV and GIV share low level aa/nt identities with other orbiviruses, in ‘conserved’ Pol, T2 and T13 proteins/genes, identifying them as four distinct virus-species. The TBO genome segment encoding cell attachment, outer capsid protein 1 (OC1, is approximately half the size of the equivalent segment from insect-borne orbiviruses, helping to explain why tick-borne orbiviruses have a ~1 kb smaller genome.

  4. Protecting Adults and Children from Blood-Borne Pathogens.

    Science.gov (United States)

    Freeman, Nancy K.; Corning, Lisa L.

    2000-01-01

    Recommends universal precautions policies and procedures to minimize for children and adults in early childhood settings the risk of infection from exposure to blood-borne pathogens such as hepatitis B or HIV. Outlines symptoms of hepatitis B and HIV/AIDS. Discusses legal and ethical implications related to inclusion. Lists resources for teachers…

  5. O Little Town of … Nazareth?: Where was Jesus Born?

    NARCIS (Netherlands)

    Mason, Steven; White, Ellen

    2016-01-01

    The Bethlehem-birth stories in Matthew and Luke are historically problematic for several well known reasons. A historically layered re-examination of all references to Jesus' origin in the NT show that he was known to be from Nazareth. Although we do not know where he was born, Nazareth has a

  6. Tick-borne encephalitis virus in horses, Austria, 2011

    Czech Academy of Sciences Publication Activity Database

    Rushton, J. O.; Lecollinet, S.; Hubálek, Zdeněk; Svobodová, Petra; Lussy, H.; Nowotny, N.

    2013-01-01

    Roč. 19, č. 4 (2013), s. 635-637 ISSN 1080-6040 Institutional support: RVO:68081766 Keywords : tick-borne encephalitis virus (TBEV) * strains Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine Impact factor: 7.327, year: 2013

  7. Seed-borne mycoflora of local and improved wheat ( Triticum ...

    African Journals Online (AJOL)

    Three varieties each of local and improved wheat (Triticum sativum) cultivars were investigated for seed-borne pathogenic mycoflora using the plate technique and laid on completely randomized design. A total 99 fungal isolate grouped into five fungal species namely; Rhizopus nigricans, Mucor spp, Penillium jenseni, ...

  8. Anisotropic Born-Mayer potential in lattice dynamics of Vanadium

    International Nuclear Information System (INIS)

    Onwuagba, B.N.

    1988-01-01

    A microscopic theory of the lattice dynamics of the transition metal vanadium is developed based on the Animalu's transition metal model potential (TMMP). The Born-Mayer potential associated with the distribution of the transition metal d-electrons is treated as anisotropic. Good agreement with experimental phonon dispersion curves longitudinal branches in the [111] direction

  9. On Born's deformed reciprocal complex gravitational theory and noncommutative gravity

    International Nuclear Information System (INIS)

    Castro, Carlos

    2008-01-01

    Born's reciprocal relativity in flat spacetimes is based on the principle of a maximal speed limit (speed of light) and a maximal proper force (which is also compatible with a maximal and minimal length duality) and where coordinates and momenta are unified on a single footing. We extend Born's theory to the case of curved spacetimes and construct a deformed Born reciprocal general relativity theory in curved spacetimes (without the need to introduce star products) as a local gauge theory of the deformed Quaplectic group that is given by the semi-direct product of U(1,3) with the deformed (noncommutative) Weyl-Heisenberg group corresponding to noncommutative generators [Z a ,Z b ]≠0. The Hermitian metric is complex-valued with symmetric and nonsymmetric components and there are two different complex-valued Hermitian Ricci tensors R μν ,S μν . The deformed Born's reciprocal gravitational action linear in the Ricci scalars R,S with Torsion-squared terms and BF terms is presented. The plausible interpretation of Z μ =E μ a Z a as noncommuting p-brane background complex spacetime coordinates is discussed in the conclusion, where E μ a is the complex vielbein associated with the Hermitian metric G μν =g (μν) +ig [μν] =E μ a E-bar ν b η ab . This could be one of the underlying reasons why string-theory involves gravity

  10. A framework to classify error in animal-borne technologies

    NARCIS (Netherlands)

    Burns, Z.T.; van Loon, E.E.

    2015-01-01

    The deployment of novel, innovative, and increasingly miniaturized devices on fauna to collect data has increased. Yet, every animal-borne technology has its shortcomings, such as limitations in its precision or accuracy. These shortcomings, here labeled as “error,” are not yet studied

  11. Microbial Flora and Food Borne Pathogens on Minced Meat and ...

    African Journals Online (AJOL)

    BACKGROUND: Food-borne pathogens are the leading cause of illness and death in developing countries. Changes in eating habits, mass catering, unsafe food storage conditions and poor hygiene practices are major contributing factors to food associated illnesses. In Ethiopia, the widespread habit of raw beef ...

  12. Applicability of refined Born approximation to non-linear equations

    International Nuclear Information System (INIS)

    Rayski, J.

    1990-01-01

    A computational method called ''Refined Born Approximation'', formerly applied exclusively to linear problems, is shown to be successfully applicable also to non-linear problems enabling me to compute bifurcations and other irregular solutions which cannot be obtained by the standard perturbation procedures. (author)

  13. Incidence and distribution of seed-borne fungi associated with ...

    African Journals Online (AJOL)

    Isolation and identification of seed-borne fungi were conducted according to standard tests described by the International Seed Testing Association (ISTA). ... tritici, Ustilago tritici, Fusarium graminearum, Fusarium culmorum, Microdochium nivale, Bipolaris sorokiniana, Alternaria alternata, Curvularia sp., Aspergillus niger, ...

  14. Acrylic polymer nanocomposite resins for water borne coating applications

    NARCIS (Netherlands)

    Nobel, M.L.

    2007-01-01

    Due to environmental and safety regulations the use of volatile organic components (VOC's) containing lacquers for exterior automotive purposes is under growing pressure. As a consequence there is a demand for more environmentally friendly alternatives like water borne coatings, high solid coatings,

  15. Growth through internationalization : an online perspective on Born Globals

    NARCIS (Netherlands)

    Dennis Nevels

    2013-01-01

    Summary: The traditional landscape in international business has changed, for decades the Uppsala model of internationalization has been key-instrument for foreign success. Since McKinsey (1993) made notice of the term Born Global times have changed. More rapidly and in increasing numbers throughout

  16. Managing Sacrococcygeal Teratoma in a New Born of a ...

    African Journals Online (AJOL)

    Managing Sacrococcygeal Teratoma in a New Born of a Psychopathic Widow: Case Report. CEO Onuoha, CC Amah, HA Ezike. Abstract. Background: Sacrococcygeal tumors are composite embryonal tumours reflecting any one or more of embryonal/foetal remnants such as germinoma, embryonal carcinoma, teratoma, ...

  17. Imitation by Second-Borns in Adult-Sibling Dyads.

    Science.gov (United States)

    Hodapp, Albert F.; LaVoie, Joseph C.

    Five- to seven-year-old second-born children from white, middle-class, intact families were the subjects for this study. Older siblings served as role model for each child, and the parent surrogate models were selected from a pool and trained to act as the child's real parent. The imitation task emphasized verbal, postural, and motor responses of…

  18. Recent characterization of cowpea aphid-borne mosaic virus ...

    African Journals Online (AJOL)

    Woodiness disease is the most important disorder of passion fruit worldwide. The causal agent in Brazil is the Cowpea aphid-borne mosaic virus (CABMV), and despite the economic relevance of passion fruit for agriculture there have been recently very few studies about this virus in Brazil and worldwide. This work reveals ...

  19. Lovelock gravities from Born-Infeld gravity theory

    Science.gov (United States)

    Concha, P. K.; Merino, N.; Rodríguez, E. K.

    2017-02-01

    We present a Born-Infeld gravity theory based on generalizations of Maxwell symmetries denoted as Cm. We analyze different configuration limits allowing to recover diverse Lovelock gravity actions in six dimensions. Further, the generalization to higher even dimensions is also considered.

  20. Bacterial food-borne pathogens in Indian food

    International Nuclear Information System (INIS)

    Bandekar, J.R.

    2015-01-01

    Food technology and food processing techniques have made tremendous advances in preservation of food and ensuring safety of food by killing food-borne pathogens. In addition to old techniques such as pasteurization, canning, dehydration, fermentation and salting, a number of new techniques such as radiation processing, high pressure technology and pulsed electric field technology are being applied for preservation of food and to ensure food safety. Total Quality Management (TQM) concepts have been developed to take care of food safety from farm to table. Hazard Analysis at Critical Control Points (HACCP) is being applied for mass scale production of food to make food free from pathogens. Despite these advances, food-borne diseases have become one of the most widespread public health problems in the world. About two thirds of all the outbreaks are traced to microbial contaminated food. According to World Health Organization (WHO) estimates, food-borne and waterborne diarrhoeal diseases kill an estimated 2 million people annually, including many children. Food safety is a major concern not only for developing countries but also for the developed countries. A number of factors such as emergence of new food-borne pathogens, development of drug resistance in pathogens, changing life style, globalization of the food supply etc. are responsible for the continuous persistence of food-borne diseases. The food-borne disease outbreaks due to E. coli O157:H7, Listeria monocytogenes, Salmonella and Campylobacter, are responsible for recall of many foods resulting in heavy losses to food industry. Due to consumer demand, a number of Ready-To-Eat (RTE) minimally processed foods are increasingly marketed; however, there is increased risk of foodborne diseases with these products. Food Technology Division of Bhabha Atomic Research Centre, Mumbai, has been working on food-borne bacterial pathogens particularly Salmonella, Campylobacter, Listeria monocytogenes, Vibrio and Aeromonasf

  1. Practical solutions to implementing "Born Semantic" data systems

    Science.gov (United States)

    Leadbetter, A.; Buck, J. J. H.; Stacey, P.

    2015-12-01

    The concept of data being "Born Semantic" has been proposed in recent years as a Semantic Web analogue to the idea of data being "born digital"[1], [2]. Within the "Born Semantic" concept, data are captured digitally and at a point close to the time of creation are annotated with markup terms from semantic web resources (controlled vocabularies, thesauri or ontologies). This allows heterogeneous data to be more easily ingested and amalgamated in near real-time due to the standards compliant annotation of the data. In taking the "Born Semantic" proposal from concept to operation, a number of difficulties have been encountered. For example, although there are recognised methods such as Header, Dictionary, Triples [3] for the compression, publication and dissemination of large volumes of triples these systems are not practical to deploy in the field on low-powered (both electrically and computationally) devices. Similarly, it is not practical for instruments to output fully formed semantically annotated data files if they are designed to be plugged into a modular system and the data to be centrally logged in the field as is the case on Argo floats and oceanographic gliders where internal bandwidth becomes an issue [2]. In light of these issues, this presentation will concentrate on pragmatic solutions being developed to the problem of generating Linked Data in near real-time systems. Specific examples from the European Commission SenseOCEAN project where Linked Data systems are being developed for autonomous underwater platforms, and from work being undertaken in the streaming of data from the Irish Galway Bay Cable Observatory initiative will be highlighted. Further, developments of a set of tools for the LogStash-ElasticSearch software ecosystem to allow the storing and retrieval of Linked Data will be introduced. References[1] A. Leadbetter & J. Fredericks, We have "born digital" - now what about "born semantic"?, European Geophysical Union General Assembly, 2014

  2. Las Born Global: Empresas de Acelerada Internacionalización

    Directory of Open Access Journals (Sweden)

    Grettel Brenes Leiva

    2013-02-01

    Full Text Available Las born global son un grupo de pequeñas y medianasempresas emprendedoras que presentan unproceso de internacionalización acelerado, es decir,inician sus actividades comerciales en el mercadomundial justo apenas nacen o en un periodo muycercano a su nacimiento. Estas empresas ingresana los nuevos mercados obviando o se brincándosealgunas de las etapas del proceso tradicional de internacionalización,gradual o por etapas, conocidocomo “modelo Uppsala”. Son entes dinamizadoresde las economías que contribuyen en el desarrolloeconómico de los países, siempre y cuando se creael clima, las condiciones y la infraestructura indispensablepara que puedan alcanzar un desarrollosostenido de sus exportaciones. Este artículo intentacaracterizar a las born global partiendo de las definiciones,características, sostenibilidad y la selección ymodo de ingreso a los mercados globales.   ABSTRACT The born global is a group of small andmedium sized entrepreneurial companies that showan accelerated internationalization process, thatis, they start their commercial activity in worldmarkets just as they are born or in a period veryclose to their conception. These companies enternew markets paying no attention to, or disregardingsome of the steps of the traditional gradual orstepwise internationalization process known as the“Uppsala model”. They are dynamizing entities oftheir economies that contribute to the economicdevelopment of their countries, as long as the essentialoperating climate, conditions and infrastructure arecreated to allow them attain a sustained developmentin their exports. This article attempts to characterizethe born global companies starting from thedefinitions, characteristics, sustainability and theirchoice of ingress mode to global markets.

  3. Neurological development of children born to liver transplant recipients.

    Science.gov (United States)

    Schreiber-Zamora, J; Kociszewska-Najman, B; Borek-Dzięcioł, B; Drozdowska-Szymczak, A; Czaplińska, N; Pawlik, O; Cyganek, A; Pietrzak, B; Wielgoś, M

    2014-10-01

    Immunosuppressive treatment used in pregnant liver recipients may have a negative impact on fetal development and successively a child. The aim of the study was to make a neurological assessment of infants and children born to liver transplant recipients (LTRs) born between December 4, 2001, and February 11, 2013, in the 1(st) Department of Obstetrics and Gynecology, Medical University of Warsaw. The study involved 88 children, of whom 44 children were born to LTR mothers, and 44 children born to women who were not organ recipients and delivered at a similar gestational age. The gestational age of neonates ranged from 33 to 41 weeks, and the birth weight ranged from 1420 g to 4100 g. The neurological examination was performed in children from 7 weeks to 10 years of age. The neurological development was assessed by a specialist in pediatric neurology. The results of the examination were divided according to the following criteria: 1) normal development, 2) slight disorders, 3) moderate disorders, and 4) severe disorders. The Fisher's exact test was used for statistical analysis. Normal development was found in 35 of 44 (79.54%) children in the LTR group and 39 of 44 (88.63%) children in the control group (P = .3827). Slight disorders were observed in 6 of 44 (13.63%) children in LTR group and 5 of 44 (11.36%) children in the control group. Moderate disorders were found only in 3 of 44 (6.81%) children in the LTR group. No severe disorders were observed in both groups. Neurological development of children born to the liver recipients who were exposed to chronic immunosuppressive treatment in their fetal lives is the same as that of children whose mothers have not undergone organ transplantation.

  4. Executive and Memory Function in Adolescents Born Very Preterm

    Science.gov (United States)

    Ment, Laura; Allan, Walter; Schneider, Karen; Vohr, Betty R.

    2011-01-01

    BACKGROUND: Many preterm children display school difficulties, which may be mediated by impairment in executive function and memory. OBJECTIVE: To evaluate executive and memory function among adolescents born preterm compared with term controls at 16 years. METHODS: A total of 337 of 437 (77%) adolescents born in 1989 to 1992 with a birth weight executive function and memory tasks. Multiple regression analyses were used to compare groups and to identify associations between selected factors and outcomes among preterm subjects. RESULTS: Adolescents born preterm, compared with term controls, showed deficits in executive function in the order of 0.4 to 0.6 SD on tasks of verbal fluency, inhibition, cognitive flexibility, planning/organization, and working memory as well as verbal and visuospatial memory. After exclusion of adolescents with neurosensory disabilities and full-scale IQ executive dysfunction, as measured with the Behavior Rating Inventory of Executive Function, on the Metacognition Index (odds ratio [OR]: 2.5 [95% confidence interval (CI): 1.2–5.1]) and the Global Executive Composite (OR: 4.2 [95% CI: 1.6–10.9]), but not on the Behavioral Regulation index (OR: 1.5 [95% CI: 0.7–3.5]). Among adolescents born preterm, severe brain injury on neonatal ultrasound and lower maternal education were the most consistent factors associated with poor outcomes. CONCLUSIONS: Even after exclusion of preterm subjects with significant disabilities, adolescents born preterm in the early 1990s were at increased risk of deficits in executive function and memory. PMID:21300680

  5. DNA microarray technique for detecting food-borne pathogens

    Directory of Open Access Journals (Sweden)

    Xing GAO

    2012-08-01

    Full Text Available Objective To study the application of DNA microarray technique for screening and identifying multiple food-borne pathogens. Methods The oligonucleotide probes were designed by Clustal X and Oligo 6.0 at the conserved regions of specific genes of multiple food-borne pathogens, and then were validated by bioinformatic analyses. The 5' end of each probe was modified by amino-group and 10 Poly-T, and the optimized probes were synthesized and spotted on aldehyde-coated slides. The bacteria DNA template incubated with Klenow enzyme was amplified by arbitrarily primed PCR, and PCR products incorporated into Aminoallyl-dUTP were coupled with fluorescent dye. After hybridization of the purified PCR products with DNA microarray, the hybridization image and fluorescence intensity analysis was acquired by ScanArray and GenePix Pro 5.1 software. A series of detection conditions such as arbitrarily primed PCR and microarray hybridization were optimized. The specificity of this approach was evaluated by 16 different bacteria DNA, and the sensitivity and reproducibility were verified by 4 food-borne pathogens DNA. The samples of multiple bacteria DNA and simulated water samples of Shigella dysenteriae were detected. Results Nine different food-borne bacteria were successfully discriminated under the same condition. The sensitivity of genomic DNA was 102 -103pg/ μl, and the coefficient of variation (CV of the reproducibility of assay was less than 15%. The corresponding specific hybridization maps of the multiple bacteria DNA samples were obtained, and the detection limit of simulated water sample of Shigella dysenteriae was 3.54×105cfu/ml. Conclusions The DNA microarray detection system based on arbitrarily primed PCR can be employed for effective detection of multiple food-borne pathogens, and this assay may offer a new method for high-throughput platform for detecting bacteria.

  6. Internalized racism and mental health among African-Americans, US-born Caribbean Blacks, and foreign-born Caribbean Blacks.

    Science.gov (United States)

    Mouzon, Dawne M; McLean, Jamila S

    2017-02-01

    The tripartite model of racism includes personally mediated racism, institutionalized racism, and the less-oft studied internalized racism. Internalized racism - or negative beliefs about one's racial group - results from cultural racism that is endemic in American society. In this project, we studied whether these negative stereotypes are associated with mental health among African-Americans and Caribbean Blacks. Using secondary data from the National Survey of American Life, we investigated the association between internalized racism and mental health (measured by depressive symptoms and serious psychological distress (SPD)) among these two groups. We also explored whether ethnicity/nativity and mastery moderate the association between internalized racism and mental health among African-Americans and Caribbean Blacks. Internalized racism was positively associated with depressive symptoms and SPD among all Black subgroups. However, internalized racism was a weaker predictor of SPD among foreign-born Caribbean Blacks than US-born Caribbean Blacks and US-born African-Americans. Additionally, higher mastery was protective against distress associated with internalized racism. Internalized racism is an important yet understudied determinant of mental health among Blacks. Future studies should take into account additional heterogeneity within the Black population (e.g. African-born individuals) and other potential protective mechanisms in addition to mastery (e.g. self-esteem and racial identity).

  7. Increased risk of peanut allergy in infants of Asian-born parents compared to those of Australian-born parents.

    Science.gov (United States)

    Koplin, J J; Peters, R L; Ponsonby, A-L; Gurrin, L C; Hill, D; Tang, M L K; Dharmage, S C; Allen, K J

    2014-12-01

    Asian infants appear to be over-represented among patients with clinical food allergy in Australia, but this has not been formally examined at the population level. Any difference in prevalence according to parental country of birth may be secondary to modifiable lifestyle factors. We aimed to quantify (i) differences in the prevalence of peanut allergy by parental country of birth and (ii) contribution of measured environmental exposures to these differences. The population-based HealthNuts study in Melbourne, Australia, screened 5276 infants (74% participation) with skin prick tests and sensitized infants underwent food challenge. Of these, 535 had a parent born in East Asia and 574 in UK/Europe. Associations between parents' country of birth and offspring peanut allergy were examined using multiple logistic regression. Compared to infants with two Australian-born parents, peanut allergy was more common among infants with parent/s born in East Asia (OR 3.4, 95% CI 2.2-5.1) but not those with parent/s born in the UK/Europe (OR 0.8, 95% CI 0.4-1.5). Paradoxically rates of allergic disease were lower among Asian parents. A higher prevalence of eczema among infants of Asian parents explained around 30% of the increase in peanut allergy, while differences in dog ownership explained around 18%. The high peanut allergy prevalence among infants of Asian-born parents appears to have occurred in a single generation and was not present among infants with parents migrating from other countries, suggesting gene-environment interactions are important. The role of eczema and microbial exposure in food allergy prevention warrants exploration. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  8. The Chinese-born immigrant infant feeding and growth hypothesis

    Directory of Open Access Journals (Sweden)

    Kristy A. Bolton

    2016-10-01

    Full Text Available Abstract Background Rapid growth in the first six months of life is a well-established risk factor for childhood obesity, and child feeding practices (supplementation or substitution of breast milk with formula and early introduction of solids have been reported to predict this. The third largest immigrant group in Australia originate from China. Case-studies reported from Victorian Maternal and Child Health nurses suggest that rapid growth trajectories in the infants of Chinese parents is common place. Furthermore, these nurses report that high value is placed by this client group on rapid growth and a fatter child; that rates of breastfeeding are low and overfeeding of infant formula is high. There are currently no studies which describe infant growth or its correlates among this immigrant group. Presentation of hypothesis We postulate that in Australia, Chinese-born immigrant mothers will have different infant feeding practices compared to non-immigrant mothers and this will result in different growth trajectories and risk of overweight. We present the Chinese-born immigrant infant feeding and growth hypothesis - that less breastfeeding, high formula feeding and early introduction of solids in infants of Chinese-born immigrant mothers living in Australia will result in a high protein intake and subsequent rapid growth trajectory and increased risk of overweight and obesity. Testing the hypothesis Three related studies will be conducted to investigate the hypothesis. These will include two quantitative studies (one cross-sectional, one longitudinal and a qualitative study. The quantitative studies will investigate differences in feeding practices in Chinese-born immigrant compared to non-immigrant mothers and infants; and the growth trajectories over the first 3.5 years of life. The qualitative study will provide more in-depth understanding of the influencing factors on feeding practices in Chinese-born immigrant mothers. Implications of the

  9. International Network for Capacity Building for the Control of Emerging Viral Vector-Borne Zoonotic Diseases: Arbo-Zoonet

    NARCIS (Netherlands)

    Ahmed, J.; Bouloy, M.; Ergonul, O.; Fooks, A.R.; Paweska, J.; Chevalier, V.; Drosten, C.; Moormann, R.J.M.; Tordo, N.; Vatansever, Z.; Calistri, P.; Estrada-Pena, A.; Mirazimi, A.; Unger, H.; Yin, H.; Seitzer, U.

    2009-01-01

    Arboviruses are arthropod-borne viruses, which include West Nile fever virus (WNFV), a mosquito-borne virus, Rift Valley fever virus (RVFV), a mosquito-borne virus, and Crimean-Congo haemorrhagic fever virus (CCHFV), a tick-borne virus. These arthropod-borne viruses can cause disease in different

  10. Regulation of the exploration and production costs of the Brazilian petroleum industry - the importance of the model adopted by Agencia Nacional de Petroleo (ANP - petroleum national agency); Regulacao dos gastos de exploracao e producao na industria petrolifera brasileira. A importancia do modelo adotado pela Agencia Nacional do Petroleo

    Energy Technology Data Exchange (ETDEWEB)

    Gutman, Jose; Leite, Getulio da Silveira [Agencia Nacional de Petroleo (ANP), Brasilia, DF (Brazil). Superintendencia de Controle das Participacoes Governamentais

    2002-07-01

    This paper describes the foundations and importance of the government directive ANP number 36, of March 7, 2001, approving the Technical Regulation of the Quarterly Expenses with Exploration, Development and Production in the Brazilian petroleum industry. For this objective, the interfaces with the Expense Reports and the special participation, with minimum local content, with the Brazilian goods and services suppliers, with the annual work program, the budget and a data bank structured with information on the capital and operational costs for the Brazilian petroleum sector. The authors concludes that the implantation of the Expenses Reports resulted in a important step for the for the success of the flexibilization process of the monopoly and the management control on the investments performed by the concessionaires.

  11. SPACE-BORNE LASER ALTIMETER GEOLOCATION ERROR ANALYSIS

    Directory of Open Access Journals (Sweden)

    Y. Wang

    2018-05-01

    Full Text Available This paper reviews the development of space-borne laser altimetry technology over the past 40 years. Taking the ICESAT satellite as an example, a rigorous space-borne laser altimeter geolocation model is studied, and an error propagation equation is derived. The influence of the main error sources, such as the platform positioning error, attitude measurement error, pointing angle measurement error and range measurement error, on the geolocation accuracy of the laser spot are analysed by simulated experiments. The reasons for the different influences on geolocation accuracy in different directions are discussed, and to satisfy the accuracy of the laser control point, a design index for each error source is put forward.

  12. A shock absorber model for structure-borne noise analyses

    Science.gov (United States)

    Benaziz, Marouane; Nacivet, Samuel; Thouverez, Fabrice

    2015-08-01

    Shock absorbers are often responsible for undesirable structure-borne noise in cars. The early numerical prediction of this noise in the automobile development process can save time and money and yet remains a challenge for industry. In this paper, a new approach to predicting shock absorber structure-borne noise is proposed; it consists in modelling the shock absorber and including the main nonlinear phenomena responsible for discontinuities in the response. The model set forth herein features: compressible fluid behaviour, nonlinear flow rate-pressure relations, valve mechanical equations and rubber mounts. The piston, base valve and complete shock absorber model are compared with experimental results. Sensitivity of the shock absorber response is evaluated and the most important parameters are classified. The response envelope is also computed. This shock absorber model is able to accurately reproduce local nonlinear phenomena and improves our state of knowledge on potential noise sources within the shock absorber.

  13. Increased organ donations from people born outside Spain.

    Science.gov (United States)

    Frutos, M A; Mansilla, J J; Ruiz, P; Guerrero, F; Lebrón, M; Ortuño, R; Daga, D; Carballo, M

    2008-11-01

    Organs donated from persons born outside Spain are becoming increasingly numerous. These persons now account for 26.1% of all donors in the "Malaga sector," an area of tourism with a high percentage of immigrants. Acceptance to donation among persons from Europe and South America is similar to that of Spanish persons but lower among those born in Africa. We must recognize the great help that cultural mediators provided not only by assistance with the language barrier but also by generating confidence among families and understanding their emotions, feelings, and traditions, mainly during interviews with families from different social and cultural miliere. To be efficient, the interpreters or cultural mediators need to have received specific training in the organ donation process and to be involved and convinced that organ donation and transplantation is the best solution for severe health problems.

  14. A differential equation for the Generalized Born radii.

    Science.gov (United States)

    Fogolari, Federico; Corazza, Alessandra; Esposito, Gennaro

    2013-06-28

    The Generalized Born (GB) model offers a convenient way of representing electrostatics in complex macromolecules like proteins or nucleic acids. The computation of atomic GB radii is currently performed by different non-local approaches involving volume or surface integrals. Here we obtain a non-linear second-order partial differential equation for the Generalized Born radius, which may be solved using local iterative algorithms. The equation is derived under the assumption that the usual GB approximation to the reaction field obeys Laplace's equation. The equation admits as particular solutions the correct GB radii for the sphere and the plane. The tests performed on a set of 55 different proteins show an overall agreement with other reference GB models and "perfect" Poisson-Boltzmann based values.

  15. Topological vortices in generalized Born-Infeld-Higgs electrodynamics

    International Nuclear Information System (INIS)

    Casana, R.; Hora, E. da; Rubiera-Garcia, D.; Santos, C. dos

    2015-01-01

    A consistent BPS formalism to study the existence of topological axially symmetric vortices in generalized versions of the Born-Infeld-Higgs electrodynamics is implemented. Such a generalization modifies the field dynamics via the introduction of three nonnegative functions depending only in the Higgs field, namely,G(vertical stroke φ vertical stroke), w(vertical stroke φ vertical stroke), and V (vertical stroke φ vertical stroke). A set of first-order differential equations is attained when these functions satisfy a constraint related to the Ampere law. Such a constraint allows one to minimize the system's energy in such way that it becomes proportional to the magnetic flux. Our results provides an enhancement of the role of topological vortex solutions in Born-Infeld-Higgs electrodynamics. Finally, we analyze a set of models entailing the recovery of a generalized version of Maxwell-Higgs electrodynamics in a certain limit of the theory. (orig.)

  16. Viral Interference and Persistence in Mosquito-Borne Flaviviruses

    Directory of Open Access Journals (Sweden)

    Juan Santiago Salas-Benito

    2015-01-01

    Full Text Available Mosquito-borne flaviviruses are important pathogens for humans, and the detection of two or more flaviviruses cocirculating in the same geographic area has often been reported. However, the epidemiological impact remains to be determined. Mosquito-borne flaviviruses are primarily transmitted through Aedes and Culex mosquitoes; these viruses establish a life-long or persistent infection without apparent pathological effects. This establishment requires a balance between virus replication and the antiviral host response. Viral interference is a phenomenon whereby one virus inhibits the replication of other viruses, and this condition is frequently associated with persistent infections. Viral interference and persistent infection are determined by several factors, such as defective interfering particles, competition for cellular factors required for translation/replication, and the host antiviral response. The interaction between two flaviviruses typically results in viral interference, indicating that these viruses share common features during the replicative cycle in the vector. The potential mechanisms involved in these processes are reviewed here.

  17. Studies on ultraviolet inactivation of air-borne microorganisms, 1

    International Nuclear Information System (INIS)

    Adachi, Shin-ichi; Doi, Hitoshi; Yamayoshi, Takao; Nunoura, Masako; Tatsumi, Noriyuki.

    1989-01-01

    UV(254nm) inactivation of air-borne bacteria in an air-controlling apparatus was studied. The appratus was composed of a chamber for vaporizing a bacterial suspension and an irradiation duct equipped with an UV lamp(GL-30). The bacterial which passed through the irradiation duct impinged on a petri dish by an air slit sampler. Selected bacteria for the experiment were Serratia marcescens, Escherichia coli, Sarcina lutea and Bacillus subtilis(spores). The apparatus was useful for the study of the susceptibility of air-borne bacteria to UV radiation. UV dose necessary to inhibit colony formation in 90% of individual bacteria in the controlled air was as low as 27 to 35% of the dose required for the agar plate method. (author)

  18. Forward modeling of space-borne gravitational wave detectors

    International Nuclear Information System (INIS)

    Rubbo, Louis J.; Cornish, Neil J.; Poujade, Olivier

    2004-01-01

    Planning is underway for several space-borne gravitational wave observatories to be built in the next 10 to 20 years. Realistic and efficient forward modeling will play a key role in the design and operation of these observatories. Space-borne interferometric gravitational wave detectors operate very differently from their ground-based counterparts. Complex orbital motion, virtual interferometry, and finite size effects complicate the description of space-based systems, while nonlinear control systems complicate the description of ground-based systems. Here we explore the forward modeling of space-based gravitational wave detectors and introduce an adiabatic approximation to the detector response that significantly extends the range of the standard low frequency approximation. The adiabatic approximation will aid in the development of data analysis techniques, and improve the modeling of astrophysical parameter extraction

  19. Water born pollutants sampling using porous suction samples

    International Nuclear Information System (INIS)

    Baig, M.A.

    1997-01-01

    The common standard method of sampling water born pollutants in the vadoze zone is core sampling and it is followed by extraction of pore fluid. This method does not allow sampling at the same location next time and again later on. There is an alternative approach for sampling fluids (water born pollutants) from both saturated and unsaturated regions of vadose zone using porous suction samplers. There are three types of porous suction samplers, vacuum-operated, pressure-vacuum lysimeters, high pressure vacuum samples. The suction samples are operated in the range of 0-70 centi bars and usually consist of ceramic and polytetrafluorethylene (PTFE). The operation range of PTFE is higher than ceramic cups. These samplers are well suited for in situ and repeated sampling form the same location. This paper discusses the physical properties and operating condition of such samplers to the utilized under our environmental sampling. (author)

  20. The Dynamic Internationalization Model of Slovenian Born Global SMEs

    Directory of Open Access Journals (Sweden)

    Ina Lejko

    2013-01-01

    Full Text Available Small and medium sized enterprises (SMEs are important businessactors in the Slovenian, as well as European economy. Inaddition to the current global market conditions, reflecting a severeeconomic downturn, the SMEs in Slovenia and other transitioneconomies operate under additional extensive external pressures,arising from the opening of their domestic markets. Undersuch conditions, companies, including SMEs, perceive internationalizationas an inevitable, or even urgent step in the processof their business operations. However, companies pursue differentpaths in their internationalization efforts, one of them beinga rapid internationalization strategy, denoted as the Born Globalconcept. In the paper, we explore the internationalization processof Slovenian Born Global SMEs. We employ an exploratory qualitativecase study analysis of selected Slovenian SMEs in order tograsp the key characteristics of their internationalization process.On the basis of the latter we construct a dynamic internationalizationmodel that might be used as a conceptual framework forempirical research of dynamic SMEs market behavior in Sloveniaand other transition countries.

  1. Analysis of Time Reversible Born-Oppenheimer Molecular Dynamics

    Directory of Open Access Journals (Sweden)

    Lin Lin

    2013-12-01

    Full Text Available We analyze the time reversible Born-Oppenheimer molecular dynamics (TRBOMD scheme, which preserves the time reversibility of the Born-Oppenheimer molecular dynamics even with non-convergent self-consistent field iteration. In the linear response regime, we derive the stability condition, as well as the accuracy of TRBOMD for computing physical properties, such as the phonon frequency obtained from the molecular dynamics simulation. We connect and compare TRBOMD with Car-Parrinello molecular dynamics in terms of accuracy and stability. We further discuss the accuracy of TRBOMD beyond the linear response regime for non-equilibrium dynamics of nuclei. Our results are demonstrated through numerical experiments using a simplified one-dimensional model for Kohn-Sham density functional theory.

  2. Massive Born--Infeld and Other Dual Pairs

    CERN Document Server

    Ferrara, S

    2015-01-01

    We consider massive dual pairs of p-forms and (D-p-1)-forms described by non-linear Lagrangians, where non-linear curvature terms in one theory translate into non-linear mass-like terms in the dual theory. In particular, for D=2p and p even the two non-linear structures coincide when the non-linear massless theory is self-dual. This state of affairs finds a natural realization in the four-dimensional massive N=1 supersymmetric Born-Infeld action, which describes either a massive vector multiplet or a massive linear (tensor) multiplet with a Born-Infeld mass-like term. These systems should play a role for the massive gravitino multiplet obtained from a partial super-Higgs in N=2 Supergravity.

  3. Maternal and Paternal Perception of Child Vulnerability and Behaviour Problems in Very Preterm Born Children

    NARCIS (Netherlands)

    Potharst, E.S.; Houtzager, B.A.; van Wassenaer-Leemhuis, A.G.; Kok, J.H.; Koot, H.M.; Last, B.F.

    2015-01-01

    Preterm born children have more behaviour problems than term born children. Perinatal risks, current child functioning, sociodemographic characteristics, parental psychological distress and parental perceptions of child vulnerability (PCV) have been shown to be risk factors for behaviour problems.

  4. Born Global Sourcers – buying internationally right from the inception

    DEFF Research Database (Denmark)

    Rask, Morten; Servais, Per

    time researchers has identified various types of INV’s and based on the empirical work by Rasmussen et al (2010) a particular type of international new venture is isolated. The Born Global sourcers which is firms who conducts international purchasing from or near their establishment but who only...... be a viable starting point for research into this type, but that this research could be supplemented by including the relations to domestic clients/partners....

  5. Optimal vaccination strategies against vector-borne diseases

    DEFF Research Database (Denmark)

    Græsbøll, Kaare; Enøe, Claes; Bødker, Rene

    2014-01-01

    Using a process oriented semi-agent based model, we simulated the spread of Bluetongue virus by Culicoides, biting midges, between cattle in Denmark. We evaluated the minimum vaccination cover and minimum cost for eight different preventive vaccination strategies in Denmark. The simulation model ...... results when index cases were in the vaccinated areas. However, given that the long-range spread of midge borne disease is still poorly quantified, more robust national vaccination schemes seem preferable....

  6. Born with low birth weight in rural Southern India

    DEFF Research Database (Denmark)

    Thomas, Nihal; Grunnet, Louise G; Poulsen, Pernille

    2012-01-01

    Low birth weight (LBW) is common in the Indian population and may represent an important predisposing factor for type 2 diabetes (T2D) and the metabolic syndrome. Intensive metabolic examinations in ethnic LBW Asian Indians have been almost exclusively performed in immigrants living outside India....... Therefore, we aimed to study the metabolic impact of being born with LBW in a rural non-migrant Indian population....

  7. Bias Gender Dalam Novel La Grande Borne Karya NH. Dini

    OpenAIRE

    Dilla, Raili Irfa; Thahar, Harris Effendi; Zulfikarni, Zulfikarni

    2013-01-01

    The purpose of this article was to describe the gender diffraction in novel La Grande Borne by Nh. Dini, evaluated from five aspects, (a) marginalization, (b) subordination, (c) stereotype, (d) violence, and (e) double work load. The data of this study was the sentences that refer to the gender diffraction.. The analyze technics were (1) describe the data, (2) analyze the data that refer to gender, (3) lnterpretated the unfair in gender, and (4) conclusion. The results of this study could be ...

  8. Aaron Temkin Beck (born July 18, 1921-) Biography

    OpenAIRE

    K. Fatih Yavuz; M. Hakan Türkçapar

    2012-01-01

    Aaron Beck was born in Providence, Rhode Island, USA, the youngest child of four siblings. Beck attended Brown University, graduating magna cum laude in 1942. Then he attended Yale Medical School, graduating with an M.D. in 1946. After his graduation, he served a rotating internship, followed by a residency in pathology at the Rhode Island Hospital. Although initially not interested in psychiatry, a residency in neurology at the Cushing Veterans Administration Hospital in Framingham, MA, requ...

  9. Bovine Tick-borne Protozoan Diseases: Emerging Threats

    OpenAIRE

    El-Ashker MR

    2013-01-01

    Tick-borne protozoan diseases, Theileriosis and Babesiosis, are major health and management problems of cattle, small ruminants and buffaloes in Africa, Asia and Latin America. Recently, tickborne diseases were ranked high in terms of their impact on poor farming communities in developing countries. Whereas the global economic importance of ticks is particularly high for livestock, there is also a relevant impact on public health in the northern hemisphere.

  10. Thyroid function testing in neonates born to women with hypothyroidism.

    Science.gov (United States)

    McGovern, Matthew; Reyani, Zahra; O'Connor, Pamela; White, Martin; Miletin, Jan

    2016-12-01

    Our aim was to assess the utility of serum thyroxine and thyroid stimulating hormone performed at 10-14 days of life in diagnosing congenital hypothyroidism (CH) in babies born to mothers with hypothyroidism. This was a retrospective study of all babies born in a tertiary referral centre for neonatology over a 12-month period. Infants who had thyroid function testing (TFT) checked at 10-14 days of life because of maternal hypothyroidism during the period of study were included. The results of the newborn bloodspot and day 10-14 TFT were recorded along with whether or not patients were subsequently treated. Of the 319 patients included in the study, only two patients were found to have CH and in both cases the newborn blood spot had been abnormal. No extra cases of CH were detected from the thyroid test at 10-14 days and this practice should be discontinued due to the robust nature of existing newborn screening programmes. What is Known: • Congenital hypothyroidism(CH) is the commonest preventable cause of childhood intellectual impairment. • Family history of hypothyroidism has been implicated as a risk factor for CH. • CH has formed part of newborn screening since the 1970s. What is New: • There is no research recommending thyroid function testing at 10-14 days of life to detect CH in neonates born to mothers with hypothyroidism. • Thyroid function testing at 10-14 days of life does not improve diagnostic yield for CH in babies born to mothers with hypothyroidism. • Newborn blood spot remains the mainstay for accurate and timely diagnosis of CH.

  11. Tick-borne encephalitis virus infection of cultured mouse macrophages

    Czech Academy of Sciences Publication Activity Database

    Ahantarig, A.; Růžek, Daniel; Vancová, Marie; Janowitz, A.; Šťastná, Hana; Tesařová, Martina; Grubhoffer, Libor

    2009-01-01

    Roč. 52, č. 5 (2009), s. 283-290 ISSN 0300-5526 R&D Projects: GA ČR GA524/06/1479; GA MŠk(CZ) LC06009 Institutional research plan: CEZ:AV0Z60220518 Keywords : tick-borne encephalitis * macrophage s * electron microscopy Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine Impact factor: 1.106, year: 2009

  12. Nucleoside Inhibitors of Tick-Borne Encephalitis Virus

    Czech Academy of Sciences Publication Activity Database

    Eyer, L.; Valdés, James J.; Gil, V.A.; Nencka, Radim; Hřebabecký, Hubert; Šála, Michal; Salát, J.; Černý, Jiří; Palus, Martin; De Clercq, E.; Růžek, Daniel

    2015-01-01

    Roč. 59, č. 9 (2015), s. 5483-5493 ISSN 0066-4804 R&D Projects: GA ČR GAP502/11/2116; GA MŠk(CZ) EE2.3.30.0032 Institutional support: RVO:60077344 ; RVO:61388963 Keywords : tick-borne encephalitis virus * infection * molecular analyses Subject RIV: EE - Microbiology, Virology; CC - Organic Chemistry (UOCHB-X) Impact factor: 4.415, year: 2015

  13. The Infant Born to a Woman with Gestational Diabetes.

    Science.gov (United States)

    Povinelli, Theresa; Lim, Caitlin; Raines, Deborah A

    2017-07-01

    Gestational diabetes mellitus (GDM) is defined as glucose intolerance with onset during pregnancy. During pregnancy, women with GDM develop insulin resistance, which results in altered glucose tolerance. As a result, there are frequent episodes of hyperglycemia and high levels of circulating amino acids, increasing the transfer of nutrients to the fetus. This article discusses the role of the mother-baby nursing in the care of neonates born to women with gestational diabetes.

  14. Memory Processes in Learning Disability Subtypes of Children Born Preterm

    OpenAIRE

    McCoy, Thomasin E.; Conrad, Amy L.; Richman, Lynn C.; Nopoulos, Peg C.; Bell, Edward F.

    2012-01-01

    The purpose of this study was to evaluate immediate auditory and visual memory processes in learning disability subtypes of 40 children born preterm. Three subgroups of children were examined: (a) primary language disability group (n = 13), (b) perceptual-motor disability group (n = 14), and (c) no learning disability diagnosis group without identified language or perceptual-motor learning disability (n = 13). Between-group comparisons indicate no significant differences in immediate auditory...

  15. Food-borne pathogens, health and role of dietary phytochemicals.

    Science.gov (United States)

    Shetty, K; Labbe, R G

    1998-12-01

    Infectious diseases transmitted by food have become a major public health concern in recent years. In the USA alone, there are an estimated 6-33 million cases each year. The list of responsible agents continues to grow. In the past 20 years some dozen new pathogens that are primarily food-borne have been identified. Fruits and vegetables, often from the global food market, have been added to the traditional vehicles of food-borne illness; that is, undercooked meat, poultry, seafood, or unpasteurized milk. Such products are minimally processed and have fewer barriers to microbial growth such as salt, sugar or preservatives. The evolution of the epidemiology of food-borne illness requires a rethinking of traditional, though still valid, solutions for their prevention. Among various strategies to prevent food-borne pathogens, use of dietary phytochemicals is promising. The major obstacle in the use of dietary phytochemical is the consistency of phytochemicals in different foods due to their natural genetic variation. We have developed a novel tissue-culture-based selection strategy to isolate elite phenolic phytochemical-producing clonal lines of species belonging to the family Lamiaceae. Among several species we have targeted elite clonal lines of thyme (Thymus vulgaris) and oregano (Origanum vulgare) against Escherichia coli and Clostridium perfrigens in fresh and processed meats. We are also evaluating high phenolic profile-containing clonal lines of basil (Ocimum basilicum) to inhibit gastric ulcer-causing Helicobacter pylori. Other elite lines of the members of the family Lamiaceae, rosemary (Rosmarinus officinalis) and salvia (Salvia officinalis) also hold promise against a wide range of food pathogens such as Salmonella species in poultry products and Vibrio species in seafood.

  16. Goddard Technology Efforts to Improve Space Borne Laser Reliability

    Science.gov (United States)

    Heaps, William S.

    2006-01-01

    In an effort to reduce the risk, perceived and actual, of employing instruments containing space borne lasers NASA initiated the Laser Risk Reduction Program (LRRP) in 2001. This program managed jointly by NASA Langley and NASA Goddard and employing lasers researchers from government, university and industrial labs is nearing the conclusion of its planned 5 year duration. This paper will describe some of the efforts and results obtained by the Goddard half of the program.

  17. Neural correlates of executive attention in adults born very preterm

    Directory of Open Access Journals (Sweden)

    Marcel Daamen

    2015-01-01

    Full Text Available Very preterm birth is associated with an increased prevalence of attention problems and may especially impair executive attention, i.e., top-down control of attentional selection in situations where distracting information interferes with the processing of task-relevant stimuli. While there are initial findings linking structural brain alterations in preterm-born individuals with attention problems, the functional basis of these problems are not well understood. The present study used an fMRI adaptation of the Attentional Network Test to examine the neural correlates of executive attention in a large sample of N = 86 adults born very preterm and/or with very low birth weight (VP/VLBW, and N = 100 term-born controls. Executive attention was measured by comparing task behavior and brain activations associated with the processing of incongruent vs. congruent arrow flanker stimuli. Consistent with subtle impairments of executive attention, the VP/VLBW group showed lower accuracy and a tendency for increased response times during the processing of incongruent stimuli. Both groups showed similar activation patters, especially within expected fronto-cingulo-parietal areas, but no significant between-group differences. Our results argue for a maintained attention-relevant network organization in high-functioning preterm born adults in spite of subtle deficits in executive attention. Gestational age and neonatal treatment variables showed associations with task behavior, and brain activation in the dorsal ACC and lateral occipital areas, suggesting that the degree of prematurity (and related neonatal complications has subtle modulatory influences on executive attention processing.

  18. Mortality differences between the foreign-born and locally-born population in France (2004-2007).

    Science.gov (United States)

    Boulogne, Roxane; Jougla, Eric; Breem, Yves; Kunst, Anton E; Rey, Grégoire

    2012-04-01

    In contrast to the situation in many European countries, the mortality of immigrants in France has been little studied. The main reasons for the lack of studies are based on ethical and ideological considerations. The objective of this study is to explore mortality by country of birth in Metropolitan (i.e. 'mainland') France. Complete mortality data were used to study the relative risks of mortality of the foreign- and locally-born populations by gender, age and cause of death for the period 2004-2007 in Metropolitan France. Analyses were conducted by countries of birth grouped into geographic areas and by the Human Development Index (HDI). The differentials in mortality between foreign-born and locally-born populations were not homogeneous. The figures varied by age (higher foreign-born mortality for the young; lower mortality for migrants aged 15-64 years), gender (female migrants more frequently had higher relative mortality than men migrants), country of birth (Eastern European-born migrants had higher mortality, while those born in Morocco, Central Asia, 'other Asian countries' and America had lower mortality) and cause of death (migrant mortality was higher overall for deaths caused by infectious diseases and diabetes, and lower for violent death and neoplasm). Moreover, mortality relative risks for male, violent deaths and cancer were positively associated with country-of-birth HDI, while female mortality and infectious disease mortality were negatively associated with country-of-birth HDI. Some important caveats have to be considered because the study did not control for individuals socioeconomic position in France, or length of residence in the host country. A strong healthy migrant effect was suggested and its intensity varies with age and gender (which may reflect different reasons for migration). For some specific causes of death, a lifestyle effect seems to explain mortality differentials. The associations between HDI and mortality show that mortality

  19. Food-borne bacteremic illnesses in febrile neutropenic children

    Directory of Open Access Journals (Sweden)

    Anselm Chi-wai Lee

    2011-08-01

    Full Text Available Bacteremia following febrile neutropenia is a serious complication in children with malignancies. Preventive measures are currently targeted at antimicrobial prophylaxis, amelioration of drug-induced neutropenia, and nosocomial spread of pathogens, with little attention to community-acquired infections. A retrospective study was conducted at a pediatric oncology center during a 3-year period to identify probable cases of food-borne infections with bacteremia. Twenty-one bacteremic illnesses affecting 15 children receiving chemotherapy or hematopoietic stem cell transplantation were reviewed. Three (14% episodes were highly suspected of a food-borne origin: a 17-year-old boy with osteosarcoma contracted Sphingomonas paucimobilis septicemia after consuming nasi lemak bought from a street hawker; a 2-year-old boy with acute lymphoblastic leukemia developed Chryseobacterium meningosepticum septicemia after a sushi dinner; a 2-year-old girl was diagnosed with acute lymphoblastic leukemia and Lactobacillus bacteremia suspected to be of probiotic origin. All of them were neutropenic at the time of the infections and the bacteremias were cleared with antibiotic treatment. Food-borne sepsis may be an important, but readily preventable, cause of bloodstream infections in pediatric oncology patients, especially in tropical countries with an abundance of culinary outlets.

  20. Adult psychological functioning of individuals born with craniofacial anomalies.

    Science.gov (United States)

    Sarwer, D B; Bartlett, S P; Whitaker, L A; Paige, K T; Pertschuk, M J; Wadden, T A

    1999-02-01

    This study represents an initial investigation into the adult psychological functioning of individuals born with craniofacial disfigurement. A total of 24 men and women born with a craniofacial anomaly completed paper and pencil measures of body image dissatisfaction, self-esteem, quality of life, and experiences of discrimination. An age- and gender-matched control group of 24 non-facially disfigured adults also completed the measures. As expected, craniofacially disfigured adults reported greater dissatisfaction with their facial appearance than did the control group. Craniofacially disfigured adults also reported significantly lower levels of self-esteem and quality of life. Dissatisfaction with facial appearance, self-esteem, and quality of life were related to self-ratings of physical attractiveness. More than one-third of craniofacially disfigured adults (38 percent) reported experiences of discrimination in employment or social settings. Among disfigured adults, psychological functioning was not related to number of surgeries, although the degree of residual facial deformity was related to increased dissatisfaction with facial appearance and greater experiences of discrimination. Results suggest that adults who were born with craniofacial disfigurement, as compared with non-facially disfigured adults, experience greater dissatisfaction with facial appearance and lower self-esteem and quality of life; however, these experiences do not seem to be universal.

  1. Observational constraints on electromagnetic Born-Infeld cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Bretón, Nora; Montiel, Ariadna [Dpto. de Física, Centro de Investigación y de Estudios Avanzados del I.P.N., Apdo. 14–740, D.F. (Mexico); Lazkoz, Ruth, E-mail: nora@fis.cinvestav.mx, E-mail: amontiel@fis.cinvestav.mx [Dpto. de Física Teórica, Universidad del País Vasco, Apdo. 644, E-48080, Bilbao (Spain)

    2012-10-01

    The cosmological model consisting of an electromagnetic Born-Infeld (BI) field coupled to a Robertson-Walker geometry is tested with the standard probes of SNIa, GRBs and direct Hubble parameter. The analysis shows that the inclusion of the nonlinear electromagnetic component does not contribute in a significative way to the observed expansion. The BI electromagnetic matter is considered with an abundance of Ω{sub BI}, that our best fit leads to Ω{sub BI} = 0.037 when tested with SNIa and the Hubble parameter data (0.1 < z < 1.75); while when tested with GRBs the result is of Ω{sub BI} = 0.304, which may indicate that this electrodynamics was important at epochs close to the appearance of large structure (z ≈ 7), although this late result has not as much reliability as that corresponding to the first two probes, since we know that the dispersion in GRBs data is still considerable. In view of these results we can rule out the electromagnetic Born-Infeld matter as the origin of the present accelerated expansion, this conclusion concerns exclusively the Born-Infeld theory.

  2. Observational constraints on electromagnetic Born-Infeld cosmology

    International Nuclear Information System (INIS)

    Bretón, Nora; Montiel, Ariadna; Lazkoz, Ruth

    2012-01-01

    The cosmological model consisting of an electromagnetic Born-Infeld (BI) field coupled to a Robertson-Walker geometry is tested with the standard probes of SNIa, GRBs and direct Hubble parameter. The analysis shows that the inclusion of the nonlinear electromagnetic component does not contribute in a significative way to the observed expansion. The BI electromagnetic matter is considered with an abundance of Ω BI , that our best fit leads to Ω BI = 0.037 when tested with SNIa and the Hubble parameter data (0.1 BI = 0.304, which may indicate that this electrodynamics was important at epochs close to the appearance of large structure (z ≈ 7), although this late result has not as much reliability as that corresponding to the first two probes, since we know that the dispersion in GRBs data is still considerable. In view of these results we can rule out the electromagnetic Born-Infeld matter as the origin of the present accelerated expansion, this conclusion concerns exclusively the Born-Infeld theory

  3. Cognitive ability in adolescents born small for gestational age

    DEFF Research Database (Denmark)

    Jensen, Rikke Beck; Juul, Anders; Larsen, Torben

    2015-01-01

    cognitive ability in late adolescence. Full-scale IQ was positively related to head circumference (HC) in adolescence (B: 1.30, 95% CI: 0.32-2.28, p=0.01). HC at birth and three months was positively associated with full-scale IQ. Catch-up growth in the group of SGA children was associated......BACKGROUND: Small size at birth may be associated with impaired cognitive ability later in life. The aim of this study was to examine the effect of being born small for gestational age (SGA), with or without intrauterine growth restriction (IUGR) on cognitive ability in late adolescence. STUDY...... with a significantly increased height, larger HC, increased levels of insulin-like growth factor-I (IGF-I) and increased full-scale IQ compared to those born SGA without catch-up growth. CONCLUSION: SGA and IUGR may not be harmful for adult cognitive ability, at least not in individuals born at near-term. However...

  4. Predicting healthcare outcomes in prematurely born infants using cluster analysis.

    Science.gov (United States)

    MacBean, Victoria; Lunt, Alan; Drysdale, Simon B; Yarzi, Muska N; Rafferty, Gerrard F; Greenough, Anne

    2018-05-23

    Prematurely born infants are at high risk of respiratory morbidity following neonatal unit discharge, though prediction of outcomes is challenging. We have tested the hypothesis that cluster analysis would identify discrete groups of prematurely born infants with differing respiratory outcomes during infancy. A total of 168 infants (median (IQR) gestational age 33 (31-34) weeks) were recruited in the neonatal period from consecutive births in a tertiary neonatal unit. The baseline characteristics of the infants were used to classify them into hierarchical agglomerative clusters. Rates of viral lower respiratory tract infections (LRTIs) were recorded for 151 infants in the first year after birth. Infants could be classified according to birth weight and duration of neonatal invasive mechanical ventilation (MV) into three clusters. Cluster one (MV ≤5 days) had few LRTIs. Clusters two and three (both MV ≥6 days, but BW ≥or <882 g respectively), had significantly higher LRTI rates. Cluster two had a higher proportion of infants experiencing respiratory syncytial virus LRTIs (P = 0.01) and cluster three a higher proportion of rhinovirus LRTIs (P < 0.001) CONCLUSIONS: Readily available clinical data allowed classification of prematurely born infants into one of three distinct groups with differing subsequent respiratory morbidity in infancy. © 2018 Wiley Periodicals, Inc.

  5. Neuronal apoptosis in the neonates born to preeclamptic mothers.

    Science.gov (United States)

    Cosar, Hese; Ozer, Erdener; Topel, Hande; Kahramaner, Zelal; Turkoglu, Ebru; Erdemir, Aydin; Sutcuoglu, Sumer; Bagriyanik, Alper; Ozer, Esra Arun

    2013-07-01

    Preeclampsia may result in uteroplacental insufficiency and chronic intrauterine fetal distress. The aim of this study is to address this issue investigating neuronal apoptosis in an experimental model of preeclampsia and to evaluate the neurological outcome of the perinatal asphyxia in the neonates born to preeclamptic mother. Two out of four pregnant Sprague-Dawley rats (preeclamptic group) were given water containing 1.8% NaCl on gestation day 15 and 22 in order to establish the model of preeclampsia whereas other two (non-preeclamptic group) received normal diet. A model of perinatal asphyxia was established on the postnatal 7th day to one preeclamptic and one non-preeclamptic dam. Overall 23 pups born to overall four dams were decapitated to assess neuronal apoptosis by the TUNEL assay. The number of apoptotic neuronal cells was significantly higher in the preeclampsia groups in comparison with the control group (p = 0.006 and p = 0.006, respectively). It was also significantly higher in the asphyctic/non-preeclamptic group than the count in the control group (p = 0.01). There was also significant difference between both asphyctic groups (p = 0.003). We conclude that preeclampsia causes small babies for the gestational age and cerebral hypoplasia. Both preeclampsia and perinatal asphyxia can cause increased neuronal apoptosis in the neonatal brains. However, the prognosis for neurological outcome is much worse when the perinatal asphyxia occurs in newborns born to preeclamptic mothers.

  6. Interpretation of second Born amplitudes in electron capture

    International Nuclear Information System (INIS)

    McGuire, J.H.; Simony, P.R.; Weaver, O.L.; Macek, J.

    1982-01-01

    Exact sound Born amplitudes for 1s-1s electron capture are presented and interpreted in terms of contributions from intermediate states off the energy shell and on the energy shell. The classical model of Thomas corresponds to two-step scattering via one particular on-shell intermediate state. In the high-velocity limit for 1s-1s capture, this on-shell intermediate state of the Thomas model accounts for one-half of the total cross section, i.e., the second Born cross section. The other half comes from off-energy-shell intermediate states near the on-shell Thomas state. Above 5 MeV both the off-shell and on-shell amplitudes have a simple structure near the Thomas peak. Below 1 MeV, contributions from a broader range of intermediate states are evident in the amplitudes. Although the contribution from the Thomas state is not large below 1 MeV, other second Born effects are significant

  7. Towards violation of Born's rule: description of a simple experiment

    International Nuclear Information System (INIS)

    Khrennikov, Andrei

    2011-01-01

    Recently a new model with hidden variables of the wave type was elaborated, so called prequantum classical statistical field theory (PCSFT). Roughly speaking PCSFT is a classical signal theory applied to a special class of signals - 'quantum systems'. PCSFT reproduces successfully all probabilistic predictions of QM, including correlations for entangled systems. This model peacefully coexists with all known no-go theorems, including Bell's theorem. In our approach QM is an approximate model. All probabilistic predictions of QM are only (quite good) approximations of 'real physical averages'. The latter are averages with respect to fluctuations of prequantum fields. In particular, Born's rule is only an approximate rule. More precise experiments should demonstrate its violation. We present a simple experiment which has to produce statistical data violating Born's rule. Since the PCSFT-presentation of this experiment may be difficult for experimenters, we reformulate consequences of PCSFT in terms of the conventional wave function. In general, deviation from Born's rule is rather small. We found an experiment amplifying this deviation. We start with a toy example. Then we present a more realistic example based on Gaussian states with very small dispersion.

  8. Born to Lead? The Effect of Birth Order on Non-Cognitive Abilities

    OpenAIRE

    Black, Sandra E.; Grönqvist, Erik; Öckert, Björn

    2017-01-01

    We study the effect of birth order on personality traits among men using population data on enlistment records and occupations for Sweden. We find that earlier born men are more emotionally stable, persistent, socially outgoing, willing to assume responsibility, and able to take initiative than later-borns. In addition, we find that birth order affects occupational sorting; first-born children are more likely to be managers, while later-born children are more likely to be self-employed. We al...

  9. HIV Transmission Dynamics Among Foreign-Born Persons in the United States.

    Science.gov (United States)

    Valverde, Eduardo E; Oster, Alexandra M; Xu, Songli; Wertheim, Joel O; Hernandez, Angela L

    2017-12-15

    In the United States (US), foreign-born persons are disproportionately affected by HIV and differ epidemiologically from US-born persons with diagnosed HIV infection. Understanding HIV transmission dynamics among foreign-born persons is important to guide HIV prevention efforts for these populations. We conducted molecular transmission network analysis to describe HIV transmission dynamics among foreign-born persons with diagnosed HIV. Using HIV-1 polymerase nucleotide sequences reported to the US National HIV Surveillance System for persons with diagnosed HIV infection during 2001-2013, we constructed a genetic distance-based transmission network using HIV-TRACE and examined the birth region of potential transmission partners in this network. Of 77,686 people, 12,064 (16%) were foreign born. Overall, 28% of foreign-born persons linked to at least one other person in the transmission network. Of potential transmission partners, 62% were born in the United States, 31% were born in the same region as the foreign-born person, and 7% were born in another region of the world. Most transmission partners of male foreign-born persons (63%) were born in the United States, whereas most transmission partners of female foreign-borns (57%) were born in their same world region. These finding suggests that a majority of HIV infections among foreign-born persons in our network occurred after immigrating to the United States. Efforts to prevent HIV infection among foreign-born persons in the United States should include information of the transmission networks in which these individuals acquire or transmit HIV to develop more targeted HIV prevention interventions.

  10. Large baby syndrome in singletons born after frozen embryo transfer (FET)

    DEFF Research Database (Denmark)

    Pinborg, Anja; Henningsen, AA; Loft, A

    2013-01-01

    Are singletons born after frozen embryo transfer (FET) at increased risk of being born large for gestational age (LGA) and if so, is this caused by intrinsic maternal factors or related to the freezing/thawing procedures?......Are singletons born after frozen embryo transfer (FET) at increased risk of being born large for gestational age (LGA) and if so, is this caused by intrinsic maternal factors or related to the freezing/thawing procedures?...

  11. Foreign-Born Instructors in the U.S.: Intercultural Competence, Teaching Strategies, and Job Satisfaction

    Science.gov (United States)

    Wasilik, Oksana

    2011-01-01

    This study examines intercultural competence, teaching strategies, and job satisfaction of foreign-born instructors in a small U.S. higher education institution. The research questions addressed by this study are: (1) How do foreign-born instructors score on intercultural competence? (2) How do foreign-born instructors' teaching strategies differ…

  12. Predictors That Influence Job Satisfaction of Foreign-Born Faculty at a Midwest Higher Educational Institution

    Science.gov (United States)

    Reeder, Mei

    2016-01-01

    Despite the increase of foreign-born faculty in U.S. higher educational institutions, studies of the factors that challenge foreign-born faculty at higher educational institutions in the U.S. remain scarce. The purpose of this quantitative study is to examine factors that impact the level of job satisfaction of foreign-born faculty at a Midwestern…

  13. Development of preschool and academic skills in children born very preterm

    NARCIS (Netherlands)

    Aarnoudse-Moens, C.S.H.; Oosterlaan, J.; Duivenvoorden, H.J.; van Goudoever, J.B.; Weisglas-Kuperus, N.

    2011-01-01

    Objective: To examine performance in preschool and academic skills in very preterm (gestational age ≤30 weeks) and term-born comparison children aged 4 to 12 years. Study design: Very preterm children (n = 200; mean age, 8.2 ± 2.5 years) born between 1996 and 2004 were compared with 230 term-born

  14. Cancer risk in children born after donor ART.

    Science.gov (United States)

    Williams, C L; Bunch, K J; Murphy, M F G; Stiller, C A; Botting, B J; Wallace, W H; Davies, M C; Sutcliffe, A G

    2018-01-01

    Do children born after donor ART have an increased risk of developing childhood cancer in comparison to the general population? This study showed no overall increased risk of childhood cancer in individuals born after donor ART. Most large population-based studies have shown no increase in overall childhood cancer incidence after non-donor ART; however, other studies have suggested small increased risks in specific cancer types, including haematological cancers. Cancer risk specifically in children born after donor ART has not been investigated to date. This retrospective cohort study utilized record linkage to determine the outcome status of all children born in Great Britain (1992-2008) after donor ART. The cohort included 12 137 members who contributed 95 389 person-years of follow-up (average follow-up 7.86 years). Records of all children born in Great Britain (England, Wales, Scotland) after all forms of donor ART (1992-2008) were linked to the UK National Registry of Childhood Tumours (NRCT) to determine the number who subsequently developed cancer by 15 years of age, by the end of 2008. Rates of overall and type specific cancer (selected a priori) were compared with age, sex and calendar year standardized population-based rates, stratifying for potential mediating/moderating factors including sex, age at diagnosis, birth weight, multiple births, maternal previous live births, assisted conception type and fresh/ cryopreserved cycles. In our cohort of 12 137 children born after donor ART (52% male, 55% singleton births), no overall increased risk of cancer was identified. There were 12 cancers detected compared to 14.4 expected (standardized incidence ratio (SIR) 0.83; 95% CI 0.43-1.45; P = 0.50). A small, significant increased risk of hepatoblastoma was found, but the numbers and absolute risks were small (ART, the rarity of specific diagnostic subgroups of childhood cancer results in few cases and therefore wide CIs for such outcomes. As this is an

  15. The shape of things to come? Obesity prevalence among foreign-born vs. US-born Mexican youth in California.

    Science.gov (United States)

    Buttenheim, Alison M; Pebley, Anne R; Hsih, Katie; Chung, Chang Y; Goldman, Noreen

    2013-02-01

    Obesity among the Mexican-origin adult population in the US has been associated with longer stays in the US and with being US- vs. Mexican-born, two proxies for acculturation. This pattern is less clear for Mexican-origin children and young adults: recent evidence suggests that it may be reversed, with foreign-born Mexican youth in the US at higher risk of obesity than their US-born Mexican-American counterparts. The objective of this study is to evaluate the hypothesis that the immigrant advantage in obesity prevalence for Mexican-origin populations in the US does not hold for children and young adults. We use data from the Los Angeles Family and Neighborhood Survey (N = 1143) and the California Health Interview Survey (N = 25,487) for respondents ages 4-24 to calculate the odds of overweight/obesity by ethnicity and nativity. We find support for the hypothesis that overweight/obesity prevalence is not significantly lower for first-generation compared to second- and third-generation Mexican-origin youth. Significantly higher obesity prevalence among the first generation was observed for young adult males (ages 18-24) and adolescent females (ages 12-17). The previously-observed protective effect against obesity risk among recent adult immigrants does not hold for Mexican-origin youth. Copyright © 2012 Elsevier Ltd. All rights reserved.

  16. The sexual and reproductive health of foreign-born women in the United States.

    Science.gov (United States)

    Tapales, Athena; Douglas-Hall, Ayana; Whitehead, Hannah

    2018-02-14

    To explore the sexual and reproductive health (SRH) behaviors, health insurance coverage and use of SRH services of women in the United States (U.S.) by nativity, disaggregated by race and ethnicity. We analyzed publicly available and restricted data from the National Survey of Family Growth to assess differences and similarities between foreign-born and U.S.-born women, both overall and within Hispanic, non-Hispanic (NH) white, NH black and NH Asian groups. A larger proportion of foreign-born women than U.S.-born women lacked health insurance coverage. Foreign-born women utilized SRH services at lower rates than U.S.-born women; this effect diminished at the multivariate level, although race and ethnicity differences remained. Overall, foreign-born women were less likely to pay for SRH services with private insurance than U.S.-born women. Foreign-born women were less likely to use the most effective contraceptive methods than U.S.-born women, with some variation across race and ethnicity: NH white and NH black foreign-born women were less likely to use highly effective contraceptive methods than their U.S.-born counterparts, but among Hispanic women, the reverse was true. Our findings demonstrate that the SRH behaviors, needs and outcomes of foreign-born women differ from those of U.S-born women within the same race/ethnic group. This paper contributes to the emergent literature on immigrants in the U.S. by laying the foundation for further research on the SRH of the foreign-born population in the country, which is critical for developing public health policies and programs to understand better and serve this growing and diverse population. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  17. Suboptimal care and maternal mortality among foreign-born women in Sweden

    DEFF Research Database (Denmark)

    Esscher, Annika; Binder-Finnema, Pauline; Bødker, Birgit

    2014-01-01

    that occurred in Sweden from 1988-2010. METHODS: A subset of maternal death records (n = 75) among foreign-born women from low- and middle-income countries and Swedish-born women were audited using structured implicit review. One case of foreign-born maternal death was matched with two native born Swedish cases...... language and suboptimal interpreter system or usage. Inadequate care occurred more often among the foreign-born (p = 0.04), whereas delays in consultation/referral and miscommunication between health care providers where equally common between the two groups. CONCLUSIONS: Suboptimal care factors, major...

  18. Behavioural skills in 7 year old children born post-term

    DEFF Research Database (Denmark)

    Olesen, Annette Wind; Olsen, Jørn; Zhu, Jin Liang

    2014-01-01

    Abstract Objective: To study behavioural skills at the age of seven in a Danish population of children born post-term. Design: Cohort study. Setting: The Danish National Birth Cohort; children born from 1997 to 2003. Population: Data was obtained from a cohort of about 100,000 women...... and their children. All singletons born in gestational week 39-45 were identified, and then restricted to children whose mothers filled out a Strength and Difficulties Questionnaire (STQ) when they were seven years of age. The study population constituted 33842 singletons (21249 born at term and 12593 born post...

  19. Firms' degree of born-globalness, international entrepreneurial orientation and export performance

    DEFF Research Database (Denmark)

    Servais, Per; Kuivalainen, Olli; Sundqvist, Sanna

    2007-01-01

    Despite the recent increase in 'born-global' studies, there has been little research on how the scale and scope of being a born-global firm affects performance: most of the earlier research takes no account either the number of or the distances between the countries on firm or export performance...... born-global pathways. The results of our empirical study on 185 Finnish exporting firms show that those that qualified as true born-globals had better export performance. Furthermore, depending on the degree of born-globalness, different dimensions of EO were of importance....

  20. Developmental outcomes of Japanese children born through Assisted Reproductive Technology (ART) in toddlerhood.

    Science.gov (United States)

    Aoki, Sayaka; Hashimoto, Keiji; Ogawa, Kohei; Horikawa, Reiko; Sago, Haruhiko

    2018-05-01

    This study aimed to investigate developmental outcomes of Japanese babies born through Assisted Reproductive Technology (ART) at ages 2 and 3. The data were gathered from 1085 children in a hospital-based cohort study conducted in Japan. The children's level of development was assessed through a parent-rated questionnaire, the Kinder Infant Development Scale, which consists of nine developmental domains. We compared the development of children born through ART and those born naturally by conducting analyses of covariance. For the analyses, the effect of maternal age, family income, parental education and multiple birth were controlled for. At 24 months, no significant difference was found between children born through ART and those born naturally in development in any domain. At 36 months, a significant difference was found in development of Receptive language (F (1, 845) = 6.148, P = 0.013), Expressive language (F (1, 845) = 4.060, P = 0.044) and Language concept (F (1, 845) = 6.968, P = 0.008). For these domains, children born through ART had a significantly higher developmental age compared to children born naturally. At age 2, no significant difference was found between the children born through ART and those born naturally in nine developmental domains, although at age 3, the children born through ART showed significantly better language development than the children born naturally. © 2018 Japan Society of Obstetrics and Gynecology.

  1. Travel patterns and characteristics of foreign-born sub-population in New York state

    Energy Technology Data Exchange (ETDEWEB)

    Chin, Shih-Miao [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hwang, Ho-Ling [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Reuscher, Tim [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wilson, Daniel W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-10-01

    According to the 2010 Census, over 22% of total New York State (NYS) residents were foreign-born and over one in three persons living in New York City (NYC) were foreign-born. Foreign-born and their dependents impact local economies in many different ways, including purchasing power, transportation service needs, business sales and receipts generated, and workforce. To allow better policy decision making and program planning of transportation developments and investments in NYS, a clear understanding of the foreign-born population’s travel characteristics and behaviors, as well as their unique transportation service needs, are necessary. This report documents the characteristics of the foreign-born population and identified differences in travel behaviors and mobility issues between foreign-born residents of NYS and their U.S.-born counterparts.

  2. Memory functions of children born with asymmetric intrauterine growth restriction.

    Science.gov (United States)

    Geva, Ronny; Eshel, Rina; Leitner, Yael; Fattal-Valevski, Aviva; Harel, Shaul

    2006-10-30

    Learning difficulties are frequently diagnosed in children born with intrauterine growth restriction (IUGR). Models of various animal species with IUGR were studied and demonstrated specific susceptibility and alterations of the hippocampal formation and its related neural structures. The main purpose was to study memory functions of children born with asymmetric IUGR in a large-scale cohort using a long-term prospective paradigm. One hundred and ten infants diagnosed with IUGR were followed-up from birth to 9 years of age. Their performance was compared with a group of 63 children with comparable gestational age and multiple socioeconomic factors. Memory functions (short-term, super- and long-term spans) for different stimuli types (verbal and visual) were evaluated using Visual Auditory Digit Span tasks (VADS), Rey Auditory Verbal Learning Test (Rey-AVLT), and Rey Osterrieth Complex Figure Test (ROCF). Children with IUGR had short-term memory difficulties that hindered both serial verbal processing system and simultaneous processing of high-load visuo-spatial stimuli. The difficulties were not related to prematurity, neonatal complications or growth catch-up, but were augmented by lower maternal education. Recognition skills and benefits from reiteration, typically affected by hippocampal dysfunction, were preserved in both groups. Memory profile of children born with IUGR is characterized primarily by a short-term memory deficit that does not necessarily comply with a typical hippocampal deficit, but rather may reflect an executive short-term memory deficit characteristic of anterior hippocampal-prefrontal network. Implications for cognitive intervention are discussed.

  3. Climate change and Ixodes tick-borne diseases of humans.

    Science.gov (United States)

    Ostfeld, Richard S; Brunner, Jesse L

    2015-04-05

    The evidence that climate warming is changing the distribution of Ixodes ticks and the pathogens they transmit is reviewed and evaluated. The primary approaches are either phenomenological, which typically assume that climate alone limits current and future distributions, or mechanistic, asking which tick-demographic parameters are affected by specific abiotic conditions. Both approaches have promise but are severely limited when applied separately. For instance, phenomenological approaches (e.g. climate envelope models) often select abiotic variables arbitrarily and produce results that can be hard to interpret biologically. On the other hand, although laboratory studies demonstrate strict temperature and humidity thresholds for tick survival, these limits rarely apply to field situations. Similarly, no studies address the influence of abiotic conditions on more than a few life stages, transitions or demographic processes, preventing comprehensive assessments. Nevertheless, despite their divergent approaches, both mechanistic and phenomenological models suggest dramatic range expansions of Ixodes ticks and tick-borne disease as the climate warms. The predicted distributions, however, vary strongly with the models' assumptions, which are rarely tested against reasonable alternatives. These inconsistencies, limited data about key tick-demographic and climatic processes and only limited incorporation of non-climatic processes have weakened the application of this rich area of research to public health policy or actions. We urge further investigation of the influence of climate on vertebrate hosts and tick-borne pathogen dynamics. In addition, testing model assumptions and mechanisms in a range of natural contexts and comparing their relative importance as competing models in a rigorous statistical framework will significantly advance our understanding of how climate change will alter the distribution, dynamics and risk of tick-borne disease.

  4. Surface singularities in Eddington-inspired Born-Infeld gravity.

    Science.gov (United States)

    Pani, Paolo; Sotiriou, Thomas P

    2012-12-21

    Eddington-inspired Born-Infeld gravity was recently proposed as an alternative to general relativity that offers a resolution of spacetime singularities. The theory differs from Einstein's gravity only inside matter due to nondynamical degrees of freedom, and it is compatible with all current observations. We show that the theory is reminiscent of Palatini f(R) gravity and that it shares the same pathologies, such as curvature singularities at the surface of polytropic stars and unacceptable Newtonian limit. This casts serious doubt on its viability.

  5. Air-borne contact dermatitis caused exclusively by xanthium strumarium

    Directory of Open Access Journals (Sweden)

    Pasricha J

    1995-01-01

    Full Text Available Most cases having air-borne contact dermatitis (ABCD in India are considered to be caused by Parthenium hysterophorus. In some cases however, other plants have also been noticed to give positive patch test reactions. We are reporting two cases presenting as ABCD who showed positive patch tests with Xanthium strumarium while the patch tests with Parthenium hysterophorus were negative. It is therefore necessary to realise that every case of ABCD is not caused by Parthenium, and patch testing with Parthenium alone can lead to serious mistakes.

  6. Air-borne contact dermatitis caused exclusively by xanthium strumarium.

    Science.gov (United States)

    Pasricha, J S; Verma, K K; D'Souza, P

    1995-01-01

    Most cases having air-borne contact dermatitis (ABCD) in India are considered to be caused by Parthenium hysterophorus. In some cases however, other plants have also been noticed to give positive patch test reactions. We are reporting two cases presenting as ABCD who showed positive patch tests with Xanthium strumarium while the patch tests with Parthenium hysterophorus were negative. It is therefore necessary to realise that every case of ABCD is not caused by Parthenium, and patch testing with Parthenium alone can lead to serious mistakes.

  7. Numerical simulation of tornado-borne missile impact

    International Nuclear Information System (INIS)

    Tu, D.K.; Murray, R.C.

    1977-01-01

    The feasibility of using a finite element procedure to examine the impact phenomenon of a tornado-borne missile impinging on a reinforced concrete barrier was assessed. The major emphasis of this study was to simulate the impact of a nondeformable missile. Several series of simulations were run, using an 8-in.-dia steel slug as the impacting missile. The numerical results were then compared with experimental field tests and empirical formulas. The work is in support of tornado design practices for fuel reprocessing and fuel fabrication plants

  8. Computed tomography of the head of new born premature infants

    International Nuclear Information System (INIS)

    Ohno, Tsutomu; Mizobe, Naoki; Takehiro, Hideo

    1983-01-01

    Evaluation of the extracerebral space on CT resulted as follows: The existence of the etracerebral space in the parieto-occipital region (PO-ECS) was physiological findings characteristic to premature infants. Its incidence was higher and the width of the space was greater, in those of premature infants. Generally PO-ECS disappeared around 40 weeks of gestation, while it tended to remaine beyond 40 weeks in premature infants born after less than 30 weeks of pregnancy. The appearance and disappearance of the PO-ECS may present some approach to learning the development of the brain in premature infants. (Ueda, J.)

  9. Born Too Soon: Care for the preterm baby

    Science.gov (United States)

    2013-01-01

    As part of a supplement entitled "Born Too Soon", this paper focuses on care of the preterm newborn. An estimated 15 million babies are born preterm, and the survival gap between those born in high and low income countries is widening, with one million deaths a year due to direct complications of preterm birth, and around one million more where preterm birth is a risk factor, especially amongst those who are also growth restricted. Most premature babies (>80%) are between 32 and 37 weeks of gestation, and many die needlessly for lack of simple care. We outline a series of packages of care that build on essential care for every newborn comprising support for immediate and exclusive breastfeeding, thermal care, and hygienic cord and skin care. For babies who do not breathe at birth, rapid neonatal resuscitation is crucial. Extra care for small babies, including Kangaroo Mother Care, and feeding support, can halve mortality in babies weighing Neonatal intensive care units in high income settings are de-intensifying care, for example increasing use of continuous positive airway pressure (CPAP) and this makes comprehensive preterm care more transferable. For health systems in low and middle income settings with increasing facility births, district hospitals are the key frontier for improving obstetric and neonatal care, and some large scale programmes now include specific newborn care strategies. However there are still around 50 million births outside facilities, hence home visits for mothers and newborns, as well as women's groups are crucial for reaching these families, often the poorest. A fundamental challenge is improving programmatic tracking data for coverage and quality, and measuring disability-free survival. The power of parent's voices has been important in high-income countries in bringing attention to preterm newborns, but is still missing from the most affected countries. Declaration This article is part of a supplement jointly funded by Save the Children

  10. Sources of Value Creation in Born Global Companies

    Directory of Open Access Journals (Sweden)

    Augustyniak Dobrochna

    2017-06-01

    Full Text Available Research about the phenomenon of rapid internationalization of small and medium size companies has evolved over the last two decades. Nevertheless, questions about business models or value creation in born global enterprises are rarely addressed in the literature. The objective of this article is to develop a theoretical framework for analyzing the sources of value creation in the business models of international new ventures (INV global companies, starting with adapting the model by Amit and Zott [2001, 2010] to early internationalizing venture. Current literature on international entrepreneurship, business models and value creation is also used as a basis for suggesting future empirical research recommendations.

  11. Born in Auschwitz and Survived: A Triumph Over Murderers.

    Science.gov (United States)

    Weisz, George M; Kwiet, Konrad

    2018-04-01

    The discovery of Jewish babies who were born in Nazi concentration camps and survived seems miraculous, but this phenomenon did occur toward the end of World War II. The lives of a small group of mothers and surviving children are of both historical and medical interests. Their survival shows additional support for the hypothesis that maternal nutrition can induce metabolic syndrome and bone demineralization in their offspring. Information obtained through direct contact with some of the surviving children is the basis for this article.

  12. Obesity Among U.S.- and Foreign-Born Blacks by Region of Birth.

    Science.gov (United States)

    Mehta, Neil K; Elo, Irma T; Ford, Nicole D; Siegel, Karen R

    2015-08-01

    Large, recent migration streams from the non-Hispanic Caribbean islands and Africa have increased the share of U.S. blacks born outside of the U.S. Little is known about health patterns in these foreign-born populations. The purpose of this study is to compare obesity levels among self-identified U.S. blacks across birth regions and examine potential explanations for subgroup differences. Data were from the 2000-2013 National Health Interview Surveys. Three birthplace subgroups were examined: individuals born in the U.S., Caribbean/South America, and Africa, aged 25-59 years. Data were analyzed in 2013-2014. Compared to U.S.-born participants, foreign-born participants had significantly lower obesity (BMI ≥30) odds. The AORs were 0.51 (Caribbean/South American-born, 95% CI=0.44, 0.58) and 0.41 (African-born, 95% CI=0.34, 0.50) with reference to U.S.-born individuals. Education, income, and cigarette smoking did not explain the favorable weight pattern of the foreign born. Among the foreign born, those residing in the U.S. for ≥15 years had 51% (95% CI=10%, 108%) higher obesity odds compared with those residing for <5 years. No statistically significant differences in obesity odds between those born in the Caribbean/South America and Africa were detected. Foreign-born blacks generally had lower obesity levels compared to their U.S.-born counterparts, which was not explained by SES or smoking behaviors. Despite this advantage, obesity prevalence among foreign-born black women was around 30%, suggesting that obesity poses a significant health risk this population. Copyright © 2015 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

  13. Dietary Sodium Intakes and Food Sources of Sodium in Canadian-Born and Asian-Born Individuals of Chinese Ethnicity at a Canadian University Campus

    Science.gov (United States)

    Yu, Yan Han; Farmer, Anna; Mager, Diana; Willows, Noreen

    2014-01-01

    Objective: To document the sodium intake and food sources of sodium of Canadian-born Chinese (CBC) and Asian-born Chinese (ABC) individuals at a Canadian university campus. Participants: Healthy adults aged 18-58 years originating from Canada, China, Hong Kong, or Taiwan were recruited from the University of Alberta (n = 40 CBC, n = 41 ABC)…

  14. Stigma, discrimination, or symptomatology differences in self-reported mental health between US-born and Somalia-born Black Americans.

    Science.gov (United States)

    Henning-Smith, Carrie; Shippee, Tetyana P; McAlpine, Donna; Hardeman, Rachel; Farah, Farhiya

    2013-05-01

    We examined differences in self-reported mental health (SRMH) between US-born and Somalia-born Black Americans compared with White Americans. We tested how SRMH was affected by stigma toward seeing a mental health provider, discrimination in the health care setting, or symptoms of depression. Data were from a 2008 survey of adults in Minnesota and were limited to US-born and Somalia-born Black and White Americans (n = 938). Somalia-born adults were more likely to report better SRMH than either US-born Black or White Americans. They also reported lower levels of discrimination (18.6%) than US-born Black Americans (33.4%), higher levels of stigma (23.6% vs 4.7%), and lower levels of depressive symptoms (9.1% vs 31.6%). Controlling for stigma, discrimination, and symptomatology, Somalia-born Black Americans reported better SRMH than White and Black Americans (odds ratio = 4.76). Mental health programming and health care providers who focus on Black Americans' mental health might be missing important sources of heterogeneity. It is essential to consider the role of race and ethnicity, but also of nativity, in mental health policy and programming.

  15. Volumetric changes of the nose and nasal airway 2 years after tooth-borne and bone-borne surgically assisted rapid maxillary expansion

    NARCIS (Netherlands)

    Nada, R.M.; Loon, B. van; Schols, J.G.J.H.; Maal, T.J.J.; Koning, M.J.J. de; Mostafa, Y.A.; Kuijpers-Jagtman, A.M.

    2013-01-01

    This study aimed to assess the effects of bone-borne and tooth-borne surgically assisted rapid maxillary expansion on the volumes of the nose and nasal airway 2 yr after maxillary expansion. This prospective cohort study included 32 patients with transverse maxillary hypoplasia. Expansion was

  16. Three-dimensional evaluation of soft tissue changes in the orofacial region after tooth-borne and bone-borne surgically assisted rapid maxillary expansion

    NARCIS (Netherlands)

    Nada, R.M.; Loon, B. van; Maal, T.J.J.; Berge, S.J.; Mostafa, Y.A.; Kuijpers-Jagtman, A.M.; Schols, J.G.J.H.

    2013-01-01

    OBJECTIVES: This study seeks to three-dimensionally assess soft tissue changes in the orofacial region following tooth-borne and bone-borne surgically assisted rapid maxillary expansion (SARME). MATERIALS AND METHODS: This prospective cohort study included 40 skeletally mature patients with

  17. Comparing disability amongst immigrants and native-born in Canada.

    Science.gov (United States)

    Newbold, K Bruce; Simone, Dylan

    2015-11-01

    Given high levels of immigration into Canada and the associated requirement to understand the health needs of new arrivals, an extensive literature has developed over the past decade that has explored immigrant health issues, including the 'healthy immigrant effect'. Surprisingly, however, issues of disability within the immigrant population have received much less attention. Using data from Statistics Canada, 2006a, 2006b Participation and Activity Limitation Survey (PALS), this paper examines disability and its covariates amongst immigrants relative to non-immigrants in Canada. Compared with their native-born counterparts, recent immigrant arrivals (within the past 10 years) were less likely to report disability and less likely to report a severe disability than the native-born. However, differences in the rates and covariates of disabilities between males and female immigrants were observed, which are partially explained by socioeconomic and sociodemographic effects. The conclusion explores potential reasons why differentials in disability rates are observed, and points to future research directions. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Multispectral image enhancement processing for microsat-borne imager

    Science.gov (United States)

    Sun, Jianying; Tan, Zheng; Lv, Qunbo; Pei, Linlin

    2017-10-01

    With the rapid development of remote sensing imaging technology, the micro satellite, one kind of tiny spacecraft, appears during the past few years. A good many studies contribute to dwarfing satellites for imaging purpose. Generally speaking, micro satellites weigh less than 100 kilograms, even less than 50 kilograms, which are slightly larger or smaller than the common miniature refrigerators. However, the optical system design is hard to be perfect due to the satellite room and weight limitation. In most cases, the unprocessed data captured by the imager on the microsatellite cannot meet the application need. Spatial resolution is the key problem. As for remote sensing applications, the higher spatial resolution of images we gain, the wider fields we can apply them. Consequently, how to utilize super resolution (SR) and image fusion to enhance the quality of imagery deserves studying. Our team, the Key Laboratory of Computational Optical Imaging Technology, Academy Opto-Electronics, is devoted to designing high-performance microsat-borne imagers and high-efficiency image processing algorithms. This paper addresses a multispectral image enhancement framework for space-borne imagery, jointing the pan-sharpening and super resolution techniques to deal with the spatial resolution shortcoming of microsatellites. We test the remote sensing images acquired by CX6-02 satellite and give the SR performance. The experiments illustrate the proposed approach provides high-quality images.

  19. Stability of a tick-borne flavivirus in milk

    Directory of Open Access Journals (Sweden)

    Danielle K Offerdahl

    2016-05-01

    Full Text Available The tick-borne flaviviruses (TBFV occur worldwide and the tick-borne encephalitis virus members of the group (TBEV often cause severe, debilitating neurological disease in humans. Although the primary route of infection is through the bite of an infected tick, alimentary infection through the consumption of TBEV-contaminated dairy products is also well-documented and is responsible for some disease in endemic areas. Experimental infection of goats, cattle, and sheep with TBEV shows that virus can be excreted in the milk of infected animals. Additionally, the virus remains infectious after exposure to low pH levels, similar to those found in the stomach. To evaluate survival of virus in milk, we studied the stability of the BSL-2 TBFV, Langat virus, in unpasteurized goat milk over time and after different thermal treatments. Virus was stable in milk maintained under refrigeration conditions; however, there was a marked reduction in virus titer after incubation at room temperature. High temperature, short time pasteurization protocols completely inactivated the virus. Interestingly, simulation of a typical thermal regime utilized for cheese did not completely inactivate the virus in milk. These findings stress the importance of proper milk handling and pasteurization processes in areas endemic for TBEV.

  20. Dualities in M-theory and Born-Infeld Theory

    International Nuclear Information System (INIS)

    Brace, Daniel M.

    2001-01-01

    We discuss two examples of duality. The first arises in the context of toroidal compactification of the discrete light cone quantization of M-theory. In the presence of nontrivial moduli coming from the M-theory three form, it has been conjectured that the system is described by supersymmetric Yang-Mills gauge theory on a noncommutative torus. We are able to provide evidence for this conjecture, by showing that the dualities of this M-theory compactification, which correspond to T-duality in Type IIA string theory, are also dualities of the noncommutative supersymmetric Yang-Mills description. One can also consider this as evidence for the accuracy of the Matrix Theory description of M-theory in this background. The second type of duality is the self-duality of theories with U(1) gauge fields. After discussing the general theory of duality invariance for theories with complex gauge fields, we are able to find a generalization of the well known U(1) Born-Infeld theory that contains any number of gauge fields and which is invariant under the maximal duality group. We then find a supersymmetric extension of our results, and also show that our results can be extended to find Born-Infeld type actions in any even dimensional spacetime

  1. Humic colloid-borne migration of uranium in sand columns

    International Nuclear Information System (INIS)

    Artinger, R.; Rabung, T.; Kim, J.I.; Sachs, S.; Schmeide, K.; Heise, K.H.; Bernhard, G.; Nitsche, H.

    2002-09-01

    Column experiments were carried out to investigate the influence of humic colloids on subsurface uranium migration. The columns were packed with well-characterized aeolian quartz sand and equilibrated with groundwater rich in humic colloids (dissolved organic carbon (DOC): 30 mg dm -3 ). U migration was studied under an Ar/1% CO 2 gas atmosphere as a function of the migration time, which was controlled by the flow velocity or the column length. In addition, the contact time of U with groundwater prior to introduction into a column was varied. U(VI) was found to be the dominant oxidation state in the spiked groundwater. The breakthrough curves indicate that U was transported as a humic colloid-borne species with a velocity up to 5% faster than the mean groundwater flow. The fraction of humic colloid-borne species increases with increasing prior contact time and also with decreasing migration time. The migration behavior was attributed to a kinetically controlled association/dissociation of U onto and from humic colloids and also a subsequent sorption of U onto the sediment surface. The column experiments provide an insight into humic colloid-mediated U migration in subsurface aquifers

  2. THE ROLE OF INTERNET IN THE BORN GLOBAL COMPANIES

    Directory of Open Access Journals (Sweden)

    Marcus Vinicius de Oliveira Brasil

    2013-06-01

    Full Text Available The process of internationalization of global companies occurs connected to the high integration through the nets of computers, especially the Internet. The technological advances have revolutionized the forms of transacting products and services. Innovation becomes the key word for this new phase established in the economy by the computer science in which the Internet is able to establish a larger integration among the enterprises, consumers and suppliers. How can the Internet contribute to the process of Internationalization of Born Globals? This theoretical paper aims to discuss the role of innovations with internet in Born Globals firms to the process of internationalization. The literature review on the subject shows that the advances of technology will require new studies about the internationalization’s process. In spite of that, the influence of the electronic business has progressed in commercial transactions. The global world requires workers who are more and more prepared to face such reality. The enterprises will have to adapt, otherwise they may fail to reduce costs and to improve their logistics. The consumers can have personalized products, while their needs are met in a more comfortable, immediate way and with less intermediates. The electronic markets revolutionize the economy by meeting old needs in a more modern and practical way.

  3. On the mathematical treatment of the Born-Oppenheimer approximation

    International Nuclear Information System (INIS)

    Jecko, Thierry

    2014-01-01

    Motivated by the paper by Sutcliffe and Woolley [“On the quantum theory of molecules,” J. Chem. Phys. 137, 22A544 (2012)], we present the main ideas used by mathematicians to show the accuracy of the Born-Oppenheimer approximation for molecules. Based on mathematical works on this approximation for molecular bound states, in scattering theory, in resonance theory, and for short time evolution, we give an overview of some rigorous results obtained up to now. We also point out the main difficulties mathematicians are trying to overcome and speculate on further developments. The mathematical approach does not fit exactly to the common use of the approximation in Physics and Chemistry. We criticize the latter and comment on the differences, contributing in this way to the discussion on the Born-Oppenheimer approximation initiated by Sutcliffe and Woolley. The paper neither contains mathematical statements nor proofs. Instead, we try to make accessible mathematically rigourous results on the subject to researchers in Quantum Chemistry or Physics

  4. On the mathematical treatment of the Born-Oppenheimer approximation

    Energy Technology Data Exchange (ETDEWEB)

    Jecko, Thierry, E-mail: thierry.jecko@u-cergy.fr [AGM, UMR 8088 du CNRS, Université de Cergy-Pontoise, Département de mathématiques, site de Saint Martin, 2 avenue Adolphe Chauvin, F-95000 Pontoise (France)

    2014-05-15

    Motivated by the paper by Sutcliffe and Woolley [“On the quantum theory of molecules,” J. Chem. Phys. 137, 22A544 (2012)], we present the main ideas used by mathematicians to show the accuracy of the Born-Oppenheimer approximation for molecules. Based on mathematical works on this approximation for molecular bound states, in scattering theory, in resonance theory, and for short time evolution, we give an overview of some rigorous results obtained up to now. We also point out the main difficulties mathematicians are trying to overcome and speculate on further developments. The mathematical approach does not fit exactly to the common use of the approximation in Physics and Chemistry. We criticize the latter and comment on the differences, contributing in this way to the discussion on the Born-Oppenheimer approximation initiated by Sutcliffe and Woolley. The paper neither contains mathematical statements nor proofs. Instead, we try to make accessible mathematically rigourous results on the subject to researchers in Quantum Chemistry or Physics.

  5. Urbanization, land tenure security and vector-borne Chagas disease

    Science.gov (United States)

    Levy, Michael Z.; Barbu, Corentin M.; Castillo-Neyra, Ricardo; Quispe-Machaca, Victor R.; Ancca-Juarez, Jenny; Escalante-Mejia, Patricia; Borrini-Mayori, Katty; Niemierko, Malwina; Mabud, Tarub S.; Behrman, Jere R.; Naquira-Velarde, Cesar

    2014-01-01

    Modern cities represent one of the fastest growing ecosystems on the planet. Urbanization occurs in stages; each stage characterized by a distinct habitat that may be more or less susceptible to the establishment of disease vector populations and the transmission of vector-borne pathogens. We performed longitudinal entomological and epidemiological surveys in households along a 1900 × 125 m transect of Arequipa, Peru, a major city of nearly one million inhabitants, in which the transmission of Trypanosoma cruzi, the aetiological agent of Chagas disease, by the insect vector Triatoma infestans, is an ongoing problem. The transect spans a cline of urban development from established communities to land invasions. We find that the vector is tracking the development of the city, and the parasite, in turn, is tracking the dispersal of the vector. New urbanizations are free of vector infestation for decades. T. cruzi transmission is very recent and concentrated in more established communities. The increase in land tenure security during the course of urbanization, if not accompanied by reasonable and enforceable zoning codes, initiates an influx of construction materials, people and animals that creates fertile conditions for epidemics of some vector-borne diseases. PMID:24990681

  6. Proportion of litters of purebred dogs born by caesarean section.

    Science.gov (United States)

    Evans, Katy M; Adams, Vicki J

    2010-02-01

    To describe the frequency of caesarean sections in a large sample of pedigree dogs in the UK. Data on the numbers of litters born in the previous 10 years were available from a cross-sectional study of dogs belonging to breed club members (2004 Kennel Club/BSAVA Scientific Committee Purebred Dog Health Survey). In this survey 151 breeds were represented with data for households that had reported on at least 10 litters (range 10-14,15): this represented 13,141 bitches which had whelped 22,005 litters. The frequency of caesarean sections was estimated as the percentage of litters that were reported to be born by caesarean section (caesarean rates) and are reported by breed. The dogs were categorised into brachycephalic, mesocephalic and dolicocephalic breeds. The 10 breeds with the highest caesarean rates were the Boston terrier, bulldog, French bulldog, mastiff, Scottish terrier, miniature bull terrier, German wirehaired pointer, Clumber spaniel, Pekingese and Dandie Dinmont terrier. In the Boston terrier, bulldog and French bulldog, the rate was > 80%. These data provide evidence for the need to monitor caesarean rates in certain breeds of dog.

  7. Tick-borne encephalitis: a disease neglected by travel medicine.

    Science.gov (United States)

    Haditsch, Martin; Kunze, Ursula

    2013-01-01

    Tick-borne encephalitis (TBE) is a vector-borne disease that is primarily transmitted to humans by infected ticks and causes infection of the central nervous system. Clinical presentations range from meningitis to encephalitis with or without myelitis, and infection may result in death or long-term neurological sequelae. TBE is endemic in regions of at least 27 European as well as in some Asian countries. Infection and disease, however, can be averted successfully by tick-bite prevention and active vaccination. The risk of infection has shifted from daily life and occupational exposure to leisure-time activities, including travelling. Outdoor activities during the tick season with contact with nature increase the risk of tick bites. Although the number of travel-associated cases is unknown, it is certainly under-estimated because there is hardly any awareness of TBE in non-endemic countries. Therefore, the majority of cases remain undiagnosed, also because of the lack of diagnostic serology, as there is no routine screening for TBE in non-endemic regions. Because of the increasing number of travellers from TBE non-endemic to endemic regions, and in view of the fact that TBE was included in the list of notifiable diseases in the European Union in September 2012, this disease needs to become an important issue in travel medicine. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Tick-borne infections in human and animal population worldwide

    Directory of Open Access Journals (Sweden)

    José Brites-Neto

    2015-03-01

    Full Text Available The abundance and activity of ectoparasites and its hosts are affected by various abiotic factors, such as climate and other organisms (predators, pathogens and competitors presenting thus multiples forms of association (obligate to facultative, permanent to intermittent and superficial to subcutaneous developed during long co-evolving processes. Ticks are ectoparasites widespread globally and its eco epidemiology are closely related to the environmental conditions. They are obligatory hematophagous ectoparasites and responsible as vectors or reservoirs at the transmission of pathogenic fungi, protozoa, viruses, rickettsia and others bacteria during their feeding process on the hosts. Ticks constitute the second vector group that transmit the major number of pathogens to humans and play a role primary for animals in the process of diseases transmission. Many studies on bioecology of ticks, considering the information related to their population dynamics, to the host and the environment, comes possible the application and efficiency of tick control measures in the prevention programs of vector-borne diseases. In this review were considered some taxonomic, morphological, epidemiological and clinical fundamental aspects related to the tick-borne infections that affect human and animal populations.

  9. Stability of a Tick-Borne Flavivirus in Milk.

    Science.gov (United States)

    Offerdahl, Danielle K; Clancy, Niall G; Bloom, Marshall E

    2016-01-01

    The tick-borne flaviviruses (TBFV) occur worldwide and the tick-borne encephalitis virus (TBEV) members of the group often cause severe, debilitating neurological disease in humans. Although the primary route of infection is through the bite of an infected tick, alimentary infection through the consumption of TBEV-contaminated dairy products is also well-documented and is responsible for some disease in endemic areas. Experimental infection of goats, cattle, and sheep with TBEV shows that the virus can be excreted in the milk of infected animals. Additionally, the virus remains infectious after exposure to low pH levels, similar to those found in the stomach. To evaluate the survival of virus in milk, we studied the stability of the BSL-2 TBFV, Langat virus, in unpasteurized goat milk over time and after different thermal treatments. Virus was stable in milk maintained under refrigeration conditions; however, there was a marked reduction in virus titer after incubation at room temperature. High temperature, short time pasteurization protocols completely inactivated the virus. Interestingly, simulation of a typical thermal regime utilized for cheese did not completely inactivate the virus in milk. These findings stress the importance of proper milk handling and pasteurization processes in areas endemic for TBEV.

  10. Born in Bradford, a cohort study of babies born in Bradford, and their parents: Protocol for the recruitment phase

    Directory of Open Access Journals (Sweden)

    Raynor Pauline

    2008-09-01

    Full Text Available Abstract Background Bradford, one of the most deprived cities in the United Kingdom, has a wide range of public health problems associated with socioeconomic deprivation, including an infant mortality rate almost double that for England and Wales. Infant mortality is highest for babies of Pakistani origin, who comprise almost half the babies born in Bradford. The Born in Bradford cohort study aims to examine environmental, psychological and genetic factors that impact on health and development perinatally, during childhood and subsequent adult life, and those that influence their parents' health and wellbeing. This protocol outlines methods for the recruitment phase of the study. Methods Most Bradford women attend for antenatal care and give birth at the Bradford Royal Infirmary, which has approximately 5,800 births per year. Women are eligible for recruitment if they plan to give birth here. Babies born from March 2007 are eligible to participate, recruitment is planned to continue until 2010. Fathers of babies recruited are invited to participate. Women are usually recruited when they attend for a routine oral glucose tolerance test at 26–28 weeks gestation. Recruitment of babies is at birth. Fathers are recruited whenever possible during the antenatal period, or soon after the birth. The aim is to recruit 10,000 women, their babies, and the babies' fathers. At recruitment women have blood samples taken, are interviewed to complete a semi-structured questionnaire, weighed, and have height, arm circumference and triceps skinfold measured. Umbilical cord blood is collected at birth. Within two weeks of birth babies have their head, arm and abdominal circumference measured, along with subscapular and triceps skinfold thickness. Fathers self-complete a questionnaire at recruitment, have height and weight measured, and provide a saliva sample. Participants are allocated a unique study number. NHS numbers will be used to facilitate record linkage

  11. Behavioural responses of two-spotted spider mites induced by predator-borne and prey-borne cues.

    Science.gov (United States)

    Gyuris, Enikő; Szép, Erna; Kontschán, Jenő; Hettyey, Attila; Tóth, Zoltán

    2017-11-01

    Applying predatory mites as biological control agents is a well established method against spider mites which are major pests worldwide. Although antipredator responses can influence the outcome of predator-prey interactions, we have limited information about what cues spider mites use to adjust their behavioural antipredator responses. We experimentally exposed two-spotted spider mites (Tetranychus urticae) to different predator-borne cues (using a specialist predator, Phytoseiulus persimilis, or a generalist predator, Amblyseius swirskii), conspecific prey-borne cues, or both, and measured locomotion and egg-laying activity. The reactions to predator species compared to each other manifested in reversed tendencies: spider mites increased their locomotion activity in the presence of P. persimilis, whereas they decreased it when exposed to A. swirskii. The strongest response was triggered by the presence of a killed conspecific: focal spider mites decreased their locomotion activity compared to the control group. Oviposition activity was not affected by either treatment. Our results point out that spider mites may change their behaviour in response to predators, and also to the presence of killed conspecifics, but these effects were not enhanced when both types of cues were present. The effect of social contacts among prey conspecifics on predator-induced behavioural defences is discussed. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. WAS THE SUN BORN IN A MASSIVE CLUSTER?

    International Nuclear Information System (INIS)

    Dukes, Donald; Krumholz, Mark R.

    2012-01-01

    A number of authors have argued that the Sun must have been born in a cluster of no more than several thousand stars, on the basis that, in a larger cluster, close encounters between the Sun and other stars would have truncated the outer solar system or excited the outer planets into eccentric orbits. However, this dynamical limit is in tension with meteoritic evidence that the solar system was exposed to a nearby supernova during or shortly after its formation; a several-thousand-star cluster is much too small to produce a massive star whose lifetime is short enough to have provided the enrichment. In this paper, we revisit the dynamical limit in the light of improved observations of the properties of young clusters. We use a series of scattering simulations to measure the velocity-dependent cross-section for disruption of the outer solar system by stellar encounters, and use this cross-section to compute the probability of a disruptive encounter as a function of birth cluster properties. We find that, contrary to prior work, the probability of disruption is small regardless of the cluster mass, and that it actually decreases rather than increases with cluster mass. Our results differ from prior work for three main reasons: (1) unlike in most previous work, we compute a velocity-dependent cross-section and properly integrate over the cluster mass-dependent velocity distribution of incoming stars; (2) we recognize that ∼90% of clusters have lifetimes of a few crossing times, rather than the 10-100 Myr adopted in many earlier models; and (3) following recent observations, we adopt a mass-independent surface density for embedded clusters, rather than a mass-independent radius as assumed many earlier papers. Our results remove the tension between the dynamical limit and the meteoritic evidence, and suggest that the Sun was born in a massive cluster. A corollary to this result is that close encounters in the Sun's birth cluster are highly unlikely to truncate the

  13. A survey of canine tick-borne diseases in India

    Directory of Open Access Journals (Sweden)

    Coleman Glen T

    2011-07-01

    Full Text Available Abstract Background There are few published reports on canine Babesia, Ehrlichia, Anaplasma, Hepatozoon and haemotropic Mycoplasma infections in India and most describe clinical disease in individual dogs, diagnosed by morphological observation of the microorganisms in stained blood smears. This study investigated the occurrence and distribution of canine tick-borne disease (TBD pathogens using a combination of conventional and molecular diagnostic techniques in four cities in India. Results On microscopy examination, only Hepatozoon gamonts were observed in twelve out of 525 (2.3%; 95% CI: 1.2, 4 blood smears. Using polymerase chain reaction (PCR, a total of 261 from 525 dogs (49.7%; 95% CI: 45.4, 54.1 in this study were infected with one or more canine tick-borne pathogen. Hepatozoon canis (30%; 95% CI: 26.0, 34.0 was the most common TBD pathogen found infecting dogs in India followed by Ehrlichia canis (20.6%; 95% CI: 17.2, 24.3, Mycoplasma haemocanis (12.2%; 95% CI: 9.5, 15.3, Anaplasma platys (6.5%; 95% CI: 4.5, 8.9, Babesia vogeli (5.5%, 95% CI: 3.7, 7.8 and Babesia gibsoni (0.2%, 95% CI: 0.01, 1.06. Concurrent infection with more than one TBD pathogen occurred in 39% of cases. Potential tick vectors, Rhipicephalus (most commonly and/or Haemaphysalis ticks were found on 278 (53% of dogs examined. Conclusions At least 6 species of canine tick-borne pathogens are present in India. Hepatozoon canis was the most common pathogen and ticks belonging to the genus Rhipicephalus were encountered most frequently. Polymerase chain reaction was more sensitive in detecting circulating pathogens compared with peripheral blood smear examination. As co-infections with canine TBD pathogens were common, Indian veterinary practitioners should be cognisant that the discovery of one such pathogen raises the potential for multiple infections which may warrant different clinical management strategies.

  14. Altered Amygdala Development and Fear Processing in Prematurely Born Infants

    Science.gov (United States)

    Cismaru, Anca Liliana; Gui, Laura; Vasung, Lana; Lejeune, Fleur; Barisnikov, Koviljka; Truttmann, Anita; Borradori Tolsa, Cristina; Hüppi, Petra S.

    2016-01-01

    Context: Prematurely born children have a high risk of developmental and behavioral disabilities. Cerebral abnormalities at term age have been clearly linked with later behavior alterations, but existing studies did not focus on the amygdala. Moreover, studies of early amygdala development after premature birth in humans are scarce. Objective: To compare amygdala volumes in very preterm infants at term equivalent age (TEA) and term born infants, and to relate premature infants’ amygdala volumes with their performance on the Laboratory Temperament Assessment Battery (Lab-TAB) fear episode at 12 months. Participants: Eighty one infants born between 2008 and 2014 at the University Hospitals of Geneva and Lausanne, taking part in longitudinal and functional imaging studies, who had undergone a magnetic resonance imaging (MRI) scan at TEA enabling manual amygdala delineation. Outcomes: Amygdala volumes assessed by manual segmentation of MRI scans; volumes of cortical and subcortical gray matter, white matter and cerebrospinal fluid (CSF) automatically segmented in 66 infants; scores for the Lab-TAB fear episode for 42 premature infants at 12 months. Results: Amygdala volumes were smaller in preterm infants at TEA than term infants (mean difference 138.03 mm3, p amygdala volumes were larger than left amygdala volumes (mean difference 36.88 mm3, p Amygdala volumes showed significant correlation with the intensity of the escape response to a fearsome toy (rs = 0.38, p = 0.013), and were larger in infants showing an escape response compared to the infants showing no escape response (mean difference 120.97 mm3, p = 0.005). Amygdala volumes were not significantly correlated with the intensity of facial fear, distress vocalizations, bodily fear and positive motor activity in the fear episode. Conclusion: Our results indicate that premature birth is associated with a reduction in amygdala volumes and white matter volumes at TEA, suggesting that altered amygdala development

  15. Tick-Borne Transmission of Murine Gammaherpesvirus 68

    Directory of Open Access Journals (Sweden)

    Valeria Hajnická

    2017-10-01

    Full Text Available Herpesviruses are a large group of DNA viruses infecting mainly vertebrates. Murine gammaherpesvirus 68 (MHV68 is often used as a model in studies of the pathogenesis of clinically important human gammaherpesviruses such as Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus. This rodent virus appears to be geographically widespread; however, its natural transmission cycle is unknown. Following detection of MHV68 in field-collected ticks, including isolation of the virus from tick salivary glands and ovaries, we investigated whether MHV68 is a tick-borne virus. Uninfected Ixodes ricinus ticks were shown to acquire the virus by feeding on experimentally infected laboratory mice. The virus survived tick molting, and the molted ticks transmitted the virus to uninfected laboratory mice on which they subsequently fed. MHV68 was isolated from the tick salivary glands, consistent with transmission via tick saliva. The virus survived in ticks without loss of infectivity for at least 120 days, and subsequently was transmitted vertically from one tick generation to the next, surviving more than 500 days. Furthermore, the F1 generation (derived from F0 infected females transmitted MHV68 to uninfected mice on which they fed, with MHV68 M3 gene transcripts detected in blood, lung, and spleen tissue of mice on which F1 nymphs and F1 adults engorged. These experimental data fulfill the transmission criteria that define an arthropod-borne virus (arbovirus, the largest biological group of viruses. Currently, African swine fever virus (ASFV is the only DNA virus recognized as an arbovirus. Like ASFV, MHV68 showed evidence of pathogenesis in ticks. Previous studies have reported MHV68 in free-living ticks and in mammals commonly infested with I. ricinus, and neutralizing antibodies to MHV68 have been detected in large mammals (e.g., deer including humans. Further studies are needed to determine if these reports are the result of tick-borne transmission

  16. Using geographical information systems to explore disparities in preterm birth rates among foreign-born and U.S.-born Black mothers.

    Science.gov (United States)

    Bloch, Joan Rosen

    2011-01-01

    To examine spatial patterns of neighborhood contextual factors of stress with preterm birth (PTB) and nativity (foreign-born and U.S.-born) among Black mothers. Descriptive geographic-spatial research. Births to Philadelphia residents during 2003-2005 in the context of Philadelphia residential neighborhoods (N = 350) were studied. All data were aggregated to neighborhood levels (census tracts). Maps were created to assess geographic-spatial patterns. A geographic information system (GIS) database was created that imported geo-coded data on births, crime (assaults with guns and domestic abuse), poverty, race, and nativity (foreign-born vs. U.S.-born). Clear visual patterns of "bad" neighborhoods emerged and were significantly associated with higher prevalence of PTB for foreign-born Black and U.S.-born Black mothers (p < .0001). This study demonstrated how GIS visually clarified important spatial patterns of adverse living conditions and PTB prevalence. Nurses can use GIS to better understand living environments of mothers and their families and to target interventions in geographical areas with the greatest service needs. Further research on individual and contextual factors is warranted to address the observed health disparities among the heterogeneous groups of foreign-born Black mothers. Despite limitations of aggregate data, it is clear that where mothers live matters. This has important implications for nursing practice and policy. © 2011 AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses.

  17. Using Geographical Information Systems to Explore Disparities in Preterm Birth Rates Among Foreign-born and U.S.-born Black Mothers

    Science.gov (United States)

    Bloch, Joan Rosen

    2012-01-01

    Objective To examine spatial patterns of neighborhood contextual factors of stress with preterm birth (PTB) and nativity (foreign-born and U.S.-born) among Black mothers. Design Descriptive geographic-spatial research. Setting & Participants Births to Philadelphia residents during 2003–2005 in the context of Philadelphia residential neighborhoods (N = 350) were studied. Methods All data were aggregated to neighborhood levels (census tracts). Maps were created to assess geographic-spatial patterns. A geographic information system (GIS) database was created that imported geo-coded data on births, crime (assaults with guns and domestic abuse), poverty, race, and nativity (foreign-born vs. U.S.-born). Results Clear visual patterns of “bad” neighborhoods emerged and were significantly associated with higher prevalence of PTB for foreign-born Black and U.S.-born Black mothers (p GIS visually clarified important spatial patterns of adverse living conditions and PTB prevalence. Nurses can use GIS to better understand living environments of mothers and their families and to target interventions in geographical areas with the greatest service needs. Further research on individual and contextual factors is warranted to address the observed health disparities among the heterogeneous groups of foreign-born Black mothers. Despite limitations of aggregate data, it is clear that where mothers live matters. This has important implications for nursing practice and policy. PMID:22273411

  18. Work Hours of Immigrant Versus U.S.-Born Female Workers.

    Science.gov (United States)

    Bae, Sung-Heui

    2017-10-01

    This study was a secondary analysis of cross-sectional data extracted from the 2011-2012 California Health Interview Survey. Data from 8,931 full-time (i.e., 21 hours or more per week) women workers aged 18 to 85 years were analyzed to examine the nature and prevalence of immigrant female workers' work hours, overtime, and related factors in the United States compared to U.S.-born female workers. Results showed that foreign-born female workers did not work longer hours than U.S.-born female workers. Foreign-born female workers who reported poor health worked longer hours than did their U.S.-born counterparts. Foreign-born female workers who were self-employed or worked in family businesses tended to work longer hours than did those women who worked for private companies or nonprofit organizations.

  19. Cancer in children and young adults born after assisted reproductive technology

    DEFF Research Database (Denmark)

    Sundh, Karin Jerhamre; Henningsen, Anna-Karina A; Källen, Karin

    2014-01-01

    STUDY QUESTION: Do children and young adults born after assisted reproductive technology (ART) have an increased risk of cancer? SUMMARY ANSWER: Children born after ART showed no overall increase in the rate of cancer when compared with children born as a result of spontaneous conception. WHAT...... IS KNOWN ALREADY: Children born after ART have more adverse perinatal outcomes, i.e. preterm births, low birthweights and birth defects. Previous studies have shown divergent results regarding the risk of cancer among children born after ART. STUDY DESIGN, SIZE, DURATION: A retrospective Nordic population...... group of children born after spontaneous conception. This control group was almost 4-fold the size of the ART group (n = 358 419) and matched for parity, year of birth and country. Data on perinatal outcomes and cancer were obtained from the National Medical Birth Registries, the Cancer Registries...

  20. Obstetric and psychosocial risk factors for Australian-born and non-Australian born women and associated pregnancy and birth outcomes: a population based cohort study.

    Science.gov (United States)

    Dahlen, Hannah Grace; Barnett, Bryanne; Kohlhoff, Jane; Drum, Maya Elizabeth; Munoz, Ana Maria; Thornton, Charlene

    2015-11-09

    One in four Australians is born overseas and 47% are either born overseas or have a parent who was. Obstetric and psychosocial risk factors for these women may differ. Data from one Sydney hospital (2012-2013) of all births recorded in the ObstetriX database were analysed (n = 3,092). Demographics, obstetric and psychosocial risk profile, obstetric interventions and complications and selected maternal and neonatal outcomes were examined for women born in Australia and overseas. Women born in Australia were younger, more likely to be primiparous (28.6 v 27.5%), be obese (32.0% v 21.4%), smoke (19.7 % v 3.0%), have an epidural (26.2% v 20.2%) and were less likely to have gestational diabetes mellitus (GDM) (6.8% v 13.7% when compared to non-Australian born women. The highest rates of GDM, Gestational Hypertension (GH) and maternal anaemia were seen in women born in China, the Philippines and Pakistan respectively. Differences were also seen in psychosocial screening between Australian and non-Australian women with Australian-born women more likely to smoke and report a mental health disorder. There was an association between having an Edinburgh Postnatal Depression Scale (EPDS) ≥ 13 and other psychosocial issues, such as thoughts of self-harm, domestic violence, childhood abuse etc. These women were also less likely to breastfeed. Women with an EPDS ≥ 13 at booking compared to women with EPDS ≤12 had a higher chance of being diagnosed with GDM (AOR 1.85 95% CI 1.14-3.0). There are significant differences in obstetric and psychosocial risk profiles and maternal and neonatal outcomes between Australian-born and non-Australian born women. In particular there appears to be an association between an EPDS of ≥13 and developing GDM, which warrants further investigation.

  1. Rede de significados para uma educação transformadora: tecendo as concepções da formação docente, filosofia e da psicologia da educação no banco de dados da ANPED nos anos 2009 a 2013 e os referenciais teóricos do cuidar = Network of meanings for a transformative education: weaving the conceptions training teachers, philosophy and the psychology of education in the database of ANPED in the years 2009 and 2013, and the referential theoretical of care

    Directory of Open Access Journals (Sweden)

    Borges, Rosália Figueiró

    2015-01-01

    Full Text Available O cuidado ocorre por uma força que move a capacidade humana de cuidar, evocando esta habilidade em nós e nos outros, ao satisfazer uma resposta a algo ou alguém que importa, atualizando nosso potencial para cuidar. O cuidado, em sua essência, deve ser aprofundado por docentes no que se refere à ontologia, epistemologia, teorias e modelos de cuidar. O estudo possibilita conhecer a relação entre a educação e o cuidar na perspectiva dos docentes do ensino superior nos processos de educar e ensinar. Dessa forma, infere-se que educador em sua formação docente revela atitudes e comportamentos que possui uma associação direta aos pressupostos teóricos do cuidar. O educador possui um papel de cuidador? Se a educação necessita de uma ambiência e de uma dinâmica social para que haja apreensão do conhecimento por parte do aluno, isso denota a existência de ações de cuidar? De que forma cuidamos dos discentes na educação superior? Trata-se de um estudo exploratório, descritivo, desenvolvido a partir de uma abordagem de pesquisa qualitativa de revisão bibliográfica em bases de dados da ANPED nos anos de 2009 e 2013. O estudo possibilita um exercício reflexivo das ações do educador como sujeito que possui uma bagagem de subjetividade e de uma formação docente permeada de valores de transformação de sua realidade para o ensino. A prática educativa possui uma estreita relação na perspectiva do cuidado e das novas tendências do ensino aprendizado no ensino superior

  2. Rocket-borne EUV-visible emission measurements

    International Nuclear Information System (INIS)

    Schmidtke, G.; Baker, K.D.; Stasek, G.

    1982-01-01

    Two rocket-borne experiments for measuring EUV atmospheric emissions have been conducted. The first measured emissions at 391.4 nm and 557.7 nm, and the second measured emissions in the range from 50 to 650 nm. Height profiles of selected auroral emissions from atomic oxygen at 130.4 nm (exhibiting resonant radiation diffusion) and from atomic oxygen at 557.7 nm, and from neutral and ionized molecular nitrogen are shown. Some details of the recorded spectra are given. In the shorter wavelength regions, emissions from atomic oxygen and nitrogen dominate. Over 140 nm, Lyman-Birge-Hopfield bands, second positive bands and Vegard-Kaplan bands of molecular nitrogen contribute most strongly except for some atomic lines. The Lyman-Birge-Hopfield bands of molecular nitrogen are relatively weak during the auroral arc as compared to the diffuse aurora

  3. Mycobacterium bovis meningitis in young Nigerian-born male

    DEFF Research Database (Denmark)

    Faurholt-Jepsen, Daniel; Lillebæk, Troels; Nielsen, Ming-Yuan

    2014-01-01

    In Denmark, tuberculous meningitis is rare. Central nervous system (CNS) involvement with Mycobacterium bovis is even rarer and has only been seen three times since 1992. We present a case of M. bovis meningitis in a previously healthy young Nigerian-born male, who had been exposed to unpasteurized...... dairy products in Nigeria but had no known contact with larger mammals. Before the development of meningitis, the patient had several contacts with the health system due to fever and non-specific symptoms. Finally, upon hospital admission, the patient was diagnosed with M. tuberculosis complex...... meningitis and treated empirically. After 13 days he was discharged without neurological sequelae. Later, the culture revealed M. bovis and treatment was adjusted accordingly....

  4. Animal Models of Tick-Borne Hemorrhagic Fever Viruses

    Directory of Open Access Journals (Sweden)

    Heinz Feldmann

    2013-05-01

    Full Text Available Tick-borne hemorrhagic fever viruses (TBHFV are detected throughout the African and Eurasian continents and are an emerging or re-emerging threat to many nations. Due to the largely sporadic incidences of these severe diseases, information on human cases and research activities in general have been limited. In the past decade, however, novel TBHFVs have emerged and areas of endemicity have expanded. Therefore, the development of countermeasures is of utmost importance in combating TBHFV as elimination of vectors and interrupting enzootic cycles is all but impossible and ecologically questionable. As in vivo models are the only way to test efficacy and safety of countermeasures, understanding of the available animal models and the development and refinement of animal models is critical in negating the detrimental impact of TBHFVs on public and animal health.

  5. Behavioral and social development of children born extremely premature

    DEFF Research Database (Denmark)

    Esbjørn, Barbara Hoff; Hansen, Bo Mølholm; Munck, Hanne

    2004-01-01

    A cohort of extremely prematurely born children and matched term controls was assessed at 5 years of age. The parents completed a questionnaire on their behavioral and social development. The purpose was to illuminate whether the children's general intellectual ability and parental sensitivity were...... associated with behavioral and social development. The index children exhibited more hyperactive behavior and had poorer social skills than the controls. Lower Full Scale IQ (FSIQ) was associated with outward reacting and hyperactive behavior and poorer social skills. Sensitive parenting was associated...... with less outward reacting and less hyperactive behavior. When controlling for differences in FSIQ and parental sensitivity, the index children persisted to have an increased risk of exhibiting hyperactive behavior but not poorer social skills. The index children with normal intellectual development...

  6. Domain wall universe in the Einstein-Born-Infeld theory

    International Nuclear Information System (INIS)

    Lee, Bum-Hoon; Lee, Wonwoo; Minamitsuji, Masato

    2009-01-01

    In this Letter, we discuss the dynamics of a domain wall universe embedded into the charged black hole spacetime of the Einstein-Born-Infeld (EBI) theory. There are four kinds of possible spacetime structures, i.e., those with no horizon, the extremal one, those with two horizons (as the Reissner-Nordstroem black hole), and those with a single horizon (as the Schwarzshild black hole). We derive the effective cosmological equations on the wall. In contrast to the previous works, we take the contribution of the electrostatic energy on the wall into account. By examining the properties of the effective potential, we find that a bounce can always happen outside the (outer) horizon. For larger masses of the black hole, the height of the barrier between the horizon and bouncing point in the effective potential becomes smaller, leading to longer time scales of bouncing process. These results are compared with those in the previous works.

  7. Born Global Firms: A Foreign Trade Related Study on Turkey

    Directory of Open Access Journals (Sweden)

    Aytaç GÖKMEN

    2013-11-01

    Full Text Available With the comprehensive advent in information and communication technologies and worldwide ease of transportation, the volume of international trade and business increased profoundly. Within this process, a Born Global Firm (BGF, right from its initiation, aims at creating competitive advantage by marketing a large volume of its products in various international markets by utilizing technological advances. Therefore, the rational behind the idea of BGF is to become an international firm in a short period of time and making international business affairs core of its business activities. Thus, the aim of this study is to review the concept of BGF theoretically and relate the issue to foreign trade affairs resting on significant sources related to the Turkish case mainly focusing on trade statistics as to review the potential development of BGFs in Turkey.

  8. A finite range coupled channel Born approximation code

    International Nuclear Information System (INIS)

    Nagel, P.; Koshel, R.D.

    1978-01-01

    The computer code OUKID calculates differential cross sections for direct transfer nuclear reactions in which multistep processes, arising from strongly coupled inelastic states in both the target and residual nuclei, are possible. The code is designed for heavy ion reactions where full finite range and recoil effects are important. Distorted wave functions for the elastic and inelastic scattering are calculated by solving sets of coupled differential equations using a Matrix Numerov integration procedure. These wave functions are then expanded into bases of spherical Bessel functions by the plane-wave expansion method. This approach allows the six-dimensional integrals for the transition amplitude to be reduced to products of two one-dimensional integrals. Thus, the inelastic scattering is treated in a coupled channel formalism while the transfer process is treated in a finite range born approximation formalism. (Auth.)

  9. Born iterative reconstruction using perturbed-phase field estimates.

    Science.gov (United States)

    Astheimer, Jeffrey P; Waag, Robert C

    2008-10-01

    A method of image reconstruction from scattering measurements for use in ultrasonic imaging is presented. The method employs distorted-wave Born iteration but does not require using a forward-problem solver or solving large systems of equations. These calculations are avoided by limiting intermediate estimates of medium variations to smooth functions in which the propagated fields can be approximated by phase perturbations derived from variations in a geometric path along rays. The reconstruction itself is formed by a modification of the filtered-backpropagation formula that includes correction terms to account for propagation through an estimated background. Numerical studies that validate the method for parameter ranges of interest in medical applications are presented. The efficiency of this method offers the possibility of real-time imaging from scattering measurements.

  10. Major congenital anomalies in babies born with Down syndrome

    DEFF Research Database (Denmark)

    Morris, Joan K; Garne, Ester; Wellesley, Diana

    2014-01-01

    Previous studies have shown that over 40% of babies with Down syndrome have a major cardiac anomaly and are more likely to have other major congenital anomalies. Since 2000, many countries in Europe have introduced national antenatal screening programs for Down syndrome. This study aimed...... to determine if the introduction of these screening programs and the subsequent termination of prenatally detected pregnancies were associated with any decline in the prevalence of additional anomalies in babies born with Down syndrome. The study sample consisted of 7,044 live births and fetal deaths with Down...... syndrome registered in 28 European population-based congenital anomaly registries covering seven million births during 2000-2010. Overall, 43.6% (95% CI: 42.4-44.7%) of births with Down syndrome had a cardiac anomaly and 15.0% (14.2-15.8%) had a non-cardiac anomaly. Female babies with Down syndrome were...

  11. Robot-borne fault tolerant calculators for nuclear use

    International Nuclear Information System (INIS)

    Giraud, A.; Robiolle, M.

    1995-01-01

    The use of robots has become a necessity in civil nuclear industry. Electronic systems of such robots must tolerate cumulative ionizing radiation dose effects. Today's objective is to reach a 3 kGy dose resistance. Difficulties and costs involved during on-site maintenance imply to warrant at least one functioning mode in the case of system failure. To improve the behaviour of robot-borne systems, the CEA Department for Nuclear Engineering Studies (DEIN) has developed a method for the selection of industrial electronic components and has built computer architectures which allows to break free from some cumulative dose sensitive parameters. This paper presents the MICADO and CADMOS architectures developed at the DEIN. (J.S.). 15 refs., 5 figs

  12. Efficient and compact hyperspectral imager for space-borne applications

    Science.gov (United States)

    Pisani, Marco; Zucco, Massimo

    2017-11-01

    In the last decades Hyperspectral Imager (HI) have become irreplaceable space-borne instruments for an increasing number of applications. A number of HIs are now operative onboard (e.g. CHRIS on PROBA), others are going to be launched (e.g. PRISMA, EnMAP, HyspIRI), many others are at the breadboard level. The researchers goal is to realize HI with high spatial and spectral resolution, having low weight and contained dimensions. The most common HI technique is based on the use of a dispersive mean (a grating or a prism) or on the use of band pass filters (tunable or linear variable). These approaches have the advantages of allowing compact devices. Another approach is based on the use of interferometer based spectrometers (Michelson or Sagnac type). The advantage of the latter is a very high efficiency in light collection because of the well-known Felgett and Jaquinot principles.

  13. An Overview of Animal Models for Arthropod-Borne Viruses.

    Science.gov (United States)

    Reynolds, Erin S; Hart, Charles E; Hermance, Meghan E; Brining, Douglas L; Thangamani, Saravanan

    2017-06-01

    Arthropod-borne viruses (arboviruses) have continued to emerge in recent years, posing a significant health threat to millions of people worldwide. The majority of arboviruses that are pathogenic to humans are transmitted by mosquitoes and ticks, but other types of arthropod vectors can also be involved in the transmission of these viruses. To alleviate the health burdens associated with arbovirus infections, it is necessary to focus today's research on disease control and therapeutic strategies. Animal models for arboviruses are valuable experimental tools that can shed light on the pathophysiology of infection and will enable the evaluation of future treatments and vaccine candidates. Ideally an animal model will closely mimic the disease manifestations observed in humans. In this review, we outline the currently available animal models for several viruses vectored by mosquitoes, ticks, and midges, for which there are no standardly available vaccines or therapeutics.

  14. Ecommerce drivers and marketing partnerships in successful export marketing of Finnish born globals

    OpenAIRE

    Penttinen, Jukka

    2015-01-01

    This study examines the utilization of ecommerce and marketing partnerships as part of born global internationalization strategies. The study will combine the existing literature of born global internationalization, export marketing strategies and ecommerce as part of internationalization to form an understanding on how two Finnish health and welfare sector born globals internationalize, and how ecommerce drivers affect their internationalization. Because of the explorative nature of the stud...

  15. Born global companies: A case study about the internationalization behaviours of Portuguese companies

    OpenAIRE

    Carlos, Diogo Miguel Pais Grou Simões

    2015-01-01

    Portuguese Born Global Companies have been performing an important role in the Portuguese market, mainly due to their innovative ideas and the positive contribution to exportations. This study focuses on the international strategies of four of these companies, comparing them with four international Non-Born Global Companies, in qualitative analysis. It will be possible to see a preference by the Non-Born Global Companies over proximate cultural countries. By following opportunities instead...

  16. Changing Survival Rate of Infants Born Before 26 Gestational Weeks

    Science.gov (United States)

    Rahman, Asad; Abdellatif, Mohamed; Sharef, Sharef W.; Fazalullah, Muhammad; Al-Senaidi, Khalfan; Khan, Ashfaq A.; Ahmad, Masood; Kripail, Mathew; Abuanza, Mazen; Bataclan, Flordeliza

    2015-01-01

    Objectives: This study aimed to evaluate the changing survival rate and morbidities among infants born before 26 gestational weeks at the Sultan Qaboos University Hospital (SQUH) in Muscat, Oman. Methods: This retrospective study assessed the mortality and morbidities of all premature infants born alive at 23–26 gestational weeks at SQUH between June 2006 and May 2013. Infants referred to SQUH within 72 hours of birth during this period were also included. Electronic records were reviewed for gestational age, gender, birth weight, maternal age, mode and place of delivery, antenatal steroid administration, morbidity and outcome. The survival rate was calculated and findings were then compared with those of a previous study conducted in the same hospital from 1991 to 1998. Rates of major morbidities were also calculated. Results: A total of 81 infants between 23–26 gestational weeks were admitted to the neonatal unit during the study period. Of these, 58.0% were male and 42.0% were female. Median gestational age was 25 weeks and mean birth weight was 770 ± 150 g. Of the 81 infants, 49 survived. The overall survival rate was 60.5% compared to 41% reported in the previous study. Respiratory distress syndrome (100.0%), retinopathy of prematurity (51.9%), bronchopulmonary dysplasia (34.6%), intraventricular haemorrhage (30.9%) and patent ductus arteriosus (28.4%) were the most common morbidities. Conclusion: The overall survival rate of infants between 23–26 gestational weeks during the study period had significantly improved in comparison to that found at the same hospital from 1991 to 1998. There is a need for the long-term neurodevelopmental follow-up of premature infants. PMID:26357555

  17. Economic downturn results in tick-borne disease upsurge

    Directory of Open Access Journals (Sweden)

    Randolph Sarah E

    2011-03-01

    Full Text Available Abstract Background The emergence of zoonoses is due both to changes in human activities and to changes in their natural wildlife cycles. One of the most significant vector-borne zoonoses in Europe, tick-borne encephalitis (TBE, doubled in incidence in 1993, largely as a consequence of the socio-economic transition from communism to capitalism and associated environmental changes. Methods To test the effect of the current economic recession, unemployment in 2009 and various socio-economic indices were compared to weather indices (derived from principal component analyses as predictors for the change in TBE case numbers in 2009 relative to 2004-08, for 14 European countries. Results Greatest increases in TBE incidence occurred in Latvia, Lithuania and Poland (91, 79 and 45%, respectively. The weather was rejected as an explanatory variable. Indicators of high background levels of poverty, e.g. percent of household expenditure on food, were significant predictors. The increase in unemployment in 2009 relative to 2008 together with 'in-work risk of poverty' is the only case in which a multivariate model has a second significant term. Conclusion Background socio-economic conditions determine susceptibility to risk of TBE, while increased unemployment triggered a sudden increase in risk. Mechanisms behind this result may include reduced resistance to infection through stress; reduced uptake of costly vaccination; and more exposure of people to infected ticks in their forest habitat as they make greater use of wild forest foods, especially in those countries, Lithuania and Poland, with major marketing opportunities in such products. Recognition of these risk factors could allow more effective protection through education and a vaccination programme targeted at the economically most vulnerable.

  18. Economic downturn results in tick-borne disease upsurge.

    Science.gov (United States)

    Godfrey, Elinor R; Randolph, Sarah E

    2011-03-15

    The emergence of zoonoses is due both to changes in human activities and to changes in their natural wildlife cycles. One of the most significant vector-borne zoonoses in Europe, tick-borne encephalitis (TBE), doubled in incidence in 1993, largely as a consequence of the socio-economic transition from communism to capitalism and associated environmental changes. To test the effect of the current economic recession, unemployment in 2009 and various socio-economic indices were compared to weather indices (derived from principal component analyses) as predictors for the change in TBE case numbers in 2009 relative to 2004-08, for 14 European countries. Greatest increases in TBE incidence occurred in Latvia, Lithuania and Poland (91, 79 and 45%, respectively). The weather was rejected as an explanatory variable. Indicators of high background levels of poverty, e.g. percent of household expenditure on food, were significant predictors. The increase in unemployment in 2009 relative to 2008 together with 'in-work risk of poverty' is the only case in which a multivariate model has a second significant term. Background socio-economic conditions determine susceptibility to risk of TBE, while increased unemployment triggered a sudden increase in risk. Mechanisms behind this result may include reduced resistance to infection through stress; reduced uptake of costly vaccination; and more exposure of people to infected ticks in their forest habitat as they make greater use of wild forest foods, especially in those countries, Lithuania and Poland, with major marketing opportunities in such products. Recognition of these risk factors could allow more effective protection through education and a vaccination programme targeted at the economically most vulnerable.

  19. No surprise in the first Born approximation for electron scattering

    International Nuclear Information System (INIS)

    Lentzen, M.

    2014-01-01

    In a recent article it is argued that the far-field expansion of electron scattering, a pillar of electron diffraction theory, is wrong (Treacy and Van Dyck, 2012 [1]). It is further argued that in the first Born approximation of electron scattering the intensity of the electron wave is not conserved to first order in the scattering potential. Thus a “mystery of the missing phase” is investigated, and the supposed flaw in scattering theory is seeked to be resolved by postulating a standing spherical electron wave (Treacy and Van Dyck, 2012 [1]). In this work we show, however, that these theses are wrong. A review of the essential parts of scattering theory with careful checks of the underlying assumptions and limitations for high-energy electron scattering yields: (1) the traditional form of the far-field expansion, comprising a propagating spherical wave, is correct; (2) there is no room for a missing phase; (3) in the first Born approximation the intensity of the scattered wave is conserved to first order in the scattering potential. The various features of high-energy electron scattering are illustrated by wave-mechanical calculations for an explicit target model, a Gaussian phase object, and for a Si atom, considering the geometric conditions in high-resolution transmission electron microscopy. - Highlights: Treacy and Van Dyck (2012) argue that the far-field expansion of electron scattering is wrong. The chief theses of that former work are wrong. There is no room for the missing phase proposed by Treacy and Van Dyck. There is no violation of the intensity conservation to first order in the scattering potential. Calculations for a phase object and an atomic target confirm traditional scattering theory

  20. Balloon-Borne Infrasound Detection of Energetic Bolide Events

    Science.gov (United States)

    Young, Eliot F.; Ballard, Courtney; Klein, Viliam; Bowman, Daniel; Boslough, Mark

    2016-10-01

    Infrasound is usually defined as sound waves below 20 Hz, the nominal limit of human hearing. Infrasound waves propagate over vast distances through the Earth's atmosphere: the CTBTO (Comprehensive Nuclear-Test-Ban Treaty Organization) has 48 installed infrasound-sensing stations around the world to detect nuclear detonations and other disturbances. In February 2013, several CTBTO infrasound stations detected infrasound signals from a large bolide that exploded over Chelyabinsk, Russia. Some stations recorded signals that had circumnavigated the Earth, over a day after the original event. The goal of this project is to improve upon the sensitivity of the CTBTO network by putting microphones on small, long-duration super-pressure balloons, with the overarching goal of studying the small end of the NEO population by using the Earth's atmosphere as a witness plate.A balloon-borne infrasound sensor is expected to have two advantages over ground-based stations: a lack of wind noise and a concentration of infrasound energy in the "stratospheric duct" between roughly 5 - 50 km altitude. To test these advantages, we have built a small balloon payload with five calibrated microphones. We plan to fly this payload on a NASA high-altitude balloon from Ft Sumner, NM in August 2016. We have arranged for three large explosions to take place in Socorro, NM while the balloon is aloft to assess the sensitivity of balloon-borne vs. ground-based infrasound sensors. We will report on the results from this test flight and the prospects for detecting/characterizing small bolides in the stratosphere.

  1. Financial cost of lymphedema borne by women with breast cancer

    Science.gov (United States)

    Xu, Ying; Kalfa, Senia; Koelmeyer, Louise; Parkinson, Bonny; Mackie, Helen; Viveros, Hector; Gollan, Paul; Taksa, Lucy

    2016-01-01

    Abstract Objective Our study examines the financial cost of lymphedema following a diagnosis of breast cancer and addresses a significant knowledge gap regarding the additional impact of lymphedema on breast cancer survivors. Methods An online national survey was conducted with 361 women who had either breast cancer without lymphedema (BC) (group 1, n = 209) or breast cancer with lymphedema (BC+LE) (group 2, n = 152). Participant recruitment was supported by the Breast Cancer Network Australia and the Australasian Lymphology Association. Results Both breast cancer and lymphedema result in significant out‐of‐pocket financial costs borne by women. Of patients with BC+LE, 80% indicated that their breast cancer diagnosis had affected them financially compared with 67% in the BC group (P < .020). For patients with lymphedema, over half (56%) indicated that this specific additional diagnosis to their breast cancer affected them financially and that costs increased with lymphedema severity. The cost of compression garments formed a large proportion of these costs (40.1%). The average number of attendances to a therapist each year was 5.8 (range, 0‐45). Twenty‐five patients (16.4%) had an episode of cellulitis in the past year. The incidence of cellulitis was 7.7% in 91 patients with subclinical or mild lymphedema compared with 29.5% of 61 patients with more extensive lymphedema (P < .001). The average out‐of‐pocket financial cost of lymphedema care borne by women was A$977 per annum, ranging from A$207 for subclinical lymphedema to over A$1400 for moderate or severe lymphedema. Conclusions This study identifies an additional detrimental effect of lymphedema on women in terms of financial costs. PMID:27479170

  2. Born Knowing: Tentacled Snakes Innately Predict Future Prey Behavior

    Science.gov (United States)

    Catania, Kenneth C.

    2010-01-01

    Background Aquatic tentacled snakes (Erpeton tentaculatus) can take advantage of their prey's escape response by startling fish with their body before striking. The feint usually startles fish toward the snake's approaching jaws. But when fish are oriented at a right angle to the jaws, the C-start escape response translates fish parallel to the snake's head. To exploit this latter response, snakes must predict the future location of the fish. Adult snakes can make this prediction. Is it learned, or are tentacled snakes born able to predict future fish behavior? Methods and Findings Laboratory-born, naïve snakes were investigated as they struck at fish. Trials were recorded at 250 or 500 frames per second. To prevent learning, snakes were placed in a water container with a clear transparency sheet or glass bottom. The chamber was placed over a channel in a separate aquarium with fish below. Thus snakes could see and strike at fish, without contact. The snake's body feint elicited C-starts in the fish below the transparency sheet, allowing strike accuracy to be quantified in relationship to the C-starts. When fish were oriented at a right angle to the jaws, naïve snakes biased their strikes to the future location of the escaping fish's head, such that the snake's jaws and the fish's translating head usually converged. Several different types of predictive strikes were observed. Conclusions The results show that some predators have adapted their nervous systems to directly compensate for the future behavior of prey in a sensory realm that usually requires learning. Instead of behavior selected during their lifetime, newborn tentacled snakes exhibit behavior that has been selected on a different scale—over many generations. Counter adaptations in fish are not expected, as tentacled snakes are rare predators exploiting fish responses that are usually adaptive. PMID:20585384

  3. Seed-borne pathogens and electrical conductivity of soybean seeds

    Directory of Open Access Journals (Sweden)

    Adriana Luiza Wain-Tassi

    2012-02-01

    Full Text Available Adequate procedures to evaluate seed vigor are important. Regarding the electrical conductivity test (EC, the interference in the test results caused by seed-borne pathogens has not been clarified. This research was carried out to study the influence of Phomopsis sojae (Leh. and Colletotrichum dematium (Pers. ex Fr. Grove var. truncata (Schw. Arx. fungi on EC results. Soybean seeds (Glycine max L. were inoculated with those fungi using potato, agar and dextrose (PDA medium with manitol (-1.0 MPa and incubated for 20 h at 25 °C. The colony diameter, index of mycelial growth, seed water content, occurrence of seed-borne pathogens, physiological potential of the seeds, measured by germination and vigor tests (seed germination index, cold test, accelerated aging and electrical conductivity, and seedling field emergence were determined. The contents of K+, Ca2+, and Mg2+ in the seed and in the soaking solution were also determined. A complete 2 × 4 factorial design with two seed sizes (5.5 and 6.5 mm and four treatments (control, seeds incubated without fungi, seeds incubated with Phomopsis and seeds incubated with Colletotrichum were used with eight (5.5 mm large seeds and six (6.5 mm large seeds replications. All seeds submitted to PDA medium had their germination reduced in comparison to the control seeds. This reduction was also observed when seed vigor and leached ions were considered. The presence of Phomopsis sojae fungus in soybean seed samples submitted to the EC test may be the cause of misleading results.

  4. Epidemiology and control of malaria and other arthropod born diseases

    Directory of Open Access Journals (Sweden)

    F. J. López-Antuñano

    1992-01-01

    Full Text Available Malaria and other arthropod born diseases remain a serious public health problem affecting the lives and health of certain social groups when the two basic strategies to control fail due to : (1 the lack of effective chemoprophylaxis/chemotherapy or the rapid development of drug resistance of the infectious agents and (2 the ineffectiveness of pesticides or the arthropod vectors develop resistance to them. These situations enhances the need for the design and implementation of other alternatives for sustainable health programmes. The application of the epidemiological methods is essential not only for analyzing the relevant data for the understanding of the biological characteristics of the infectious agents, their reservoirs and vectors and the methods for their control, but also for the assessment of the human behaviour, the environmental, social and economic factors involved in disease transmission and the capacity of the health systems to implement interventions for both changes in human behaviour and environmental management to purpose guaranteed prevention and control of malaria and other arthropod born diseases with efficiency, efficacy and equity. This paper discuss the evolution of the malaria arthropod diseases programmes in the American Region and the perspectives for their integration into health promotion programs and emphasis is made in the need to establish solid basis in the decision-making process for the selection of intervention strategies to remove the risk factors determining the probability to get sick or die from ABDs. The implications of the general planning and the polices to be adopted in an area should be analyzed in the light of programme feasibility at the local level, in the multisectoral context specific social groups and taking in consideration the principles of stratification and equity

  5. Arthropod-Borne Diseases: The Camper's Uninvited Guests.

    Science.gov (United States)

    Juckett, Gregory

    2015-08-01

    Arthropod-borne diseases are a major problem whenever outdoor activities bring arthropods and people into contact. The arthropods discussed here include arachnids (ticks) and insects. Most arthropod bites and stings are minor, with the notable exception being bee-sting anaphylaxis. Ticks cause the most disease transmission. Key hard tick vectors include black-legged (Ixodes), dog (Dermacentor), and lone star (Amblyomma) ticks, which transmit Lyme and various rickettsial diseases. Insect repellents, permethrin sprays, and proper tick inspection reduce this risk significantly. Lyme disease and the milder southern-tick-associated rash illness (STARI) are characterized by the erythema migrans rash followed, in the case of Lyme disease, by early, disseminated, and late systemic symptoms. Treatment is with doxycycline or ceftriaxone. Indefinite treatment of "chronic Lyme disease" based on subjective symptoms is not beneficial. Rickettsial diseases include ehrlichiosis, anaplasmosis, and Rocky Mountain spotted fever, which are characterized by fever, headache, and possible rash and should be empirically treated with doxycycline while awaiting laboratory confirmation. Tularemia is a bacterial disease (Francisella) spread by ticks and rabbits and characterized by fever and adenopathy. Treatment is with gentamicin or streptomycin. Babesiosis is a protozoal disease, mimicking malaria, that causes a self-limited flu-like disease in healthy hosts but can be life threatening with immune compromise. Treatment is with atovaquone and azithromycin. Other tick-related conditions include viral diseases (Powassan, Colorado tick fever, heartland virus), tick-borne relapsing fever (Borrelia), and tick paralysis (toxin). Mosquitoes, lice, fleas, and mites are notable for their annoying bites but are increasingly significant disease vectors even in the United States.

  6. Profile of tuberculosis among the foreign-born population in Japan, 2007-2014.

    Science.gov (United States)

    Kawatsu, Lisa; Uchimura, Kazuhiro; Izumi, Kiyohiko; Ohkado, Akihiro; Ishikawa, Nobukatsu

    2016-01-01

    The proportion of foreign-born people among the newly notified tuberculosis (TB) patients has been increasing in recent years and potentially poses a new challenge to TB control in Japan. In this report, we analysed the data from the Japan TB surveillance system between 2007 and 2014 to gain an overview of the trends and characteristics of foreign-born TB patients in Japan. We found that the proportion of foreign-born TB patients was especially high among the younger age groups - 44.1% among the 20-29 years age group in 2014. The largest groups of foreign-born patients were from China and the Philippines; however, the number of those from Nepal and Viet Nam was on the rise. Students comprised the second largest professional category group for TB after regular workers, and its proportion increased over the study period. Compared to Japan-born TB patients, foreign-born patients were more likely to be diagnosed through routine medical check-ups. Treatment successes and patients still on treatment were significantly lower among foreign-born patients than their Japan-born counterparts; and transferred-out and unknown outcomes were higher. Our results indicated that distinctive subgroups within the foreign-born population in Japan, especially students and regular workers, might have a higher risk of developing TB. Measures to ensure early diagnosis and treatment adherence should be adapted to such populations.

  7. Profile of tuberculosis among the foreign-born population in Japan, 2007–2014

    Science.gov (United States)

    Uchimura, Kazuhiro; Izumi, Kiyohiko; Ohkado, Akihiro; Ishikawa, Nobukatsu

    2016-01-01

    The proportion of foreign-born people among the newly notified tuberculosis (TB) patients has been increasing in recent years and potentially poses a new challenge to TB control in Japan. In this report, we analysed the data from the Japan TB surveillance system between 2007 and 2014 to gain an overview of the trends and characteristics of foreign-born TB patients in Japan. We found that the proportion of foreign-born TB patients was especially high among the younger age groups – 44.1% among the 20–29 years age group in 2014. The largest groups of foreign-born patients were from China and the Philippines; however, the number of those from Nepal and Viet Nam was on the rise. Students comprised the second largest professional category group for TB after regular workers, and its proportion increased over the study period. Compared to Japan-born TB patients, foreign-born patients were more likely to be diagnosed through routine medical check-ups. Treatment successes and patients still on treatment were significantly lower among foreign-born patients than their Japan-born counterparts; and transferred-out and unknown outcomes were higher. Our results indicated that distinctive subgroups within the foreign-born population in Japan, especially students and regular workers, might have a higher risk of developing TB. Measures to ensure early diagnosis and treatment adherence should be adapted to such populations. PMID:27508086

  8. New-born born with patent vitellointestinal duct with prolapsed (intussusceptions of proximal and distal ileal loop: A case presentation

    Directory of Open Access Journals (Sweden)

    Fariha Akil Fazal

    2017-05-01

    Full Text Available Failure of obliteration of vitellointestinal duct (VID can present with a wide variety of congenital intestinal malformations. Patient can present with the anomaly itself or due to complications secondary to the anomaly like intestinal obstruction due to volvulus, intussusception or adhesions. Prolapsed ilial loops through a patent VID is a rare presentation of the above. To date only fourteen cases of this presentation have been reported in the English medical literature. We are reporting a case of the same in a new-born presenting with it from the time of birth, which to the best of our knowledge has not been reported before and therefore this the youngest reported case of its nature in the current English medical literature.

  9. Post-term surveillance and birth outcomes in South Asian-born compared with Australian-born women.

    Science.gov (United States)

    Yim, C; Wong, L; Cabalag, C; Wallace, E M; Davies-Tuck, M

    2017-02-01

    To determine if apparently healthy post-term South Asian-born (SA) women were more likely to have abnormal post-term fetal surveillance than Australian- and New Zealand-born (AUS/NZ) women, whether those abnormalities were associated with increased rates of obstetric intervention and adverse perinatal outcomes, and whether SA women and their babies were at higher risk of adverse outcomes in the post-term period irrespective of their post-term surveillance outcomes. Post-term surveillance and perinatal outcomes of 145 SA and 272 AUS/NZ nulliparous women with a singleton post-term pregnancy were compared in a retrospective multicentre cohort analysis. Post-term SA women were not significantly more likely to have a low amniotic fluid index (AFI) than AUS/NZ women. However, they were nearly four times more likely (odds ratio 3.75; 95% CI 1.49-9.44) to have an abnormal CTG (P=0.005). Irrespective of maternal region of birth having an abnormal cardiotocography (CTG) or AFI was not associated with adverse intrapartum or perinatal outcomes. However, post-term SA women were significantly more likely than AUS/NZ women to have intrapartum fetal compromise (P=0.03) and an intrapartum cesarean section (P=0.002). Babies of SA women were more also significantly likely to be admitted to the Special Care Nursery or Neonatal Intensive Care Unit (P=0.02). Post-term SA women experience higher rates of fetal compromise (antenatal and intrapartum) and obstetric intervention than AUS/NZ women. Irrespective of maternal region of birth an abnormal CTG or AFI was not predictive of adverse outcomes.

  10. Characteristics of US-Born Versus Foreign-Born Americans of African Descent With Chronic Hepatitis B.

    Science.gov (United States)

    Hassan, Mohamed A; Kim, W Ray; Li, Ruosha; Smith, Coleman I; Fried, Michael W; Sterling, Richard K; Ghany, Marc G; Wahed, Abdus S; Ganova-Raeva, Lilia M; Roberts, Lewis R; Lok, Anna S F

    2017-08-01

    Hepatitis B virus (HBV) infection is more common in African Americans than in white Americans. We compared the epidemiologic, clinical, and virological characteristics of US-born African Americans (USAAs) to those of foreign-born African Americans (FBAAs) with chronic hepatitis B. The adult cohort study of the Hepatitis B Research Network enrolls patients with HBV infection from 21 clinical sites in the United States and Canada. A total of 237 (15%) of the adult participants with chronic HBV infection that were enrolled from January 20, 2011, to October 2, 2013, were of African descent, including 57 USAAs and 180 FBAAs (76%). Compared with FBAAs, USAAs were older and more likely to have acquired HBV through sexual exposure, to be HBeAg-positive, to have higher HBV DNA levels, and to be infected with HBV genotype A2. FBAAs from West Africa were more likely to have elevated serum alanine aminotransferase (72% vs. 50%; P < 0.01) and higher HBV DNA levels (median, 3.2 log10 IU/mL vs. 2.8 log10 IU/mL; P = 0.03) compared with East African FBAAs. The predominant HBV genotype among West African FBAAs was E (67%), whereas genotypes A (78%) and D (16%) were common in East African FBAAs. Significant differences were found between USAAs and FBAAs, highlighting the need for tailored strategies for prevention and management of chronic HBV infection for African Americans. © The Author(s) 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  11. Impact of Neighborhood Environments on Health Consciousness, Information Seeking, and Attitudes among US-Born and Non-US-Born Free Clinic Patients.

    Science.gov (United States)

    Kamimura, Akiko; Ashby, Jeanie; Jess, Allison; Trinh, Ha Ngoc; Nourian, Maziar M; Finlayson, Sarah Yukie; Prudencio, Liana; Reel, Justine J

    2015-12-01

    This study examined the impact of neighborhood environments on health consciousness, information seeking, and attitudes among uninsured free clinic patients to better understand the specific needs of the population for health promotion and prevention efforts. US-born English-speaking, non-US-born English-speaking, and Spanish-speaking free clinic patients completed a self-administered survey using reliable measures in autumn 2014 (N = 769). The results of this study suggest that social cohesion is positively associated with health consciousness, information seeking, and attitudes. Lower levels of available healthy food in the community were associated with higher levels of health consciousness. Although Spanish speakers reported lower levels of the availability of healthy food, social cohesion, and access to the Internet or text messaging compared with US-born or non-US-born English speakers, they were more likely to be health conscious and have higher levels of health information seeking. Spanish speakers as well as non-US-born English speakers, were more likely to attend health education classes compared with US-born English speakers. Health education programs for free clinic patients should include strategies to increase social cohesion. Health education programs should consider the diverse needs of these individual populations to maximize the effectiveness of the programs for free clinic patients.

  12. Radar sensing via a Micro-UAV-borne system

    Science.gov (United States)

    Catapano, Ilaria; Ludeno, Giovanni; Gennarelli, Gianluca; Soldovieri, Francesco; Rodi Vetrella, Amedeo; Fasano, Giancarmine

    2017-04-01

    In recent years, the miniaturization of flight control systems and payloads has contributed to a fast and widespread diffusion of micro-UAV (Unmanned Aircraft Vehicle). While micro-UAV can be a powerful tool in several civil applications such as environmental monitoring and surveillance, unleashing their full potential for societal benefits requires augmenting their sensing capability beyond the realm of active/passive optical sensors [1]. In this frame, radar systems are drawing attention since they allow performing missions in all-weather and day/night conditions and, thanks to the microwave ability to penetrate opaque media, they enable the detection and localization not only of surface objects but also of sub-surface/hidden targets. However, micro-UAV-borne radar imaging represents still a new frontier, since it is much more than a matter of technology miniaturization or payload installation, which can take advantage of the newly developed ultralight systems. Indeed, micro-UAV-borne radar imaging entails scientific challenges in terms of electromagnetic modeling and knowledge of flight dynamics and control. As a consequence, despite Synthetic Aperture Radar (SAR) imaging is a traditional remote sensing tool, its adaptation to micro-UAV is an open issue and so far only few case studies concerning the integration of SAR and UAV technologies have been reported worldwide [2]. In addition, only early results concerning subsurface imaging by means of an UAV-mounted radar are available [3]. As a contribution to radar imaging via autonomous micro-UAV, this communication presents a proof-of-concept experiment. This experiment represents the first step towards the development of a general methodological approach that exploits expertise about (sub-)surface imaging and aerospace systems with the aim to provide high-resolution images of the surveyed scene. In details, at the conference, we will present the results of a flight campaign carried out by using a single radar

  13. UAV-Borne Profiling Radar for Forest Research

    Directory of Open Access Journals (Sweden)

    Yuwei Chen

    2017-01-01

    Full Text Available Microwave Radar is an attractive solution for forest mapping and inventories because microwave signals penetrates into the forest canopy and the backscattering signal can provide information regarding the whole forest structure. Satellite-borne and airborne imaging radars have been used in forest resources mapping for many decades. However, their accuracy with respect to the main forest inventory attributes substantially varies depending on the wavelength and techniques used in the estimation. Systems providing canopy backscatter as a function of canopy height are, practically speaking, missing. Therefore, there is a need for a radar system that would enable the scientific community to better understand the radar backscatter response from the forest canopy. Consequently, we undertook a research study to develop an unmanned aerial vehicle (UAV-borne profiling (i.e., waveform radar that could be used to improve the understanding of the radar backscatter response for forestry mapping and inventories. A frequency modulation continuous waveform (FMCW profiling radar, termed FGI-Tomoradar, was introduced, designed and tested. One goal is the total weight of the whole system is less than 7 kg, including the radar system and georeferencing system, with centimetre-level positioning accuracy. Achieving this weight goal would enable the FGI-Tomoradar system to be installed on the Mini-UAV platform. The prototype system had all four linear polarization measuring capabilities, with bistatic configuration in Ku-band. In system performance tests in this study, FGI-Tomoradar was mounted on a manned helicopter together with a Riegl VQ-480-U laser scanner and tested in several flight campaigns performed at the Evo site, Finland. Airborne laser scanning data was simultaneously collected to investigate the differences and similarities of the outputs for the same target area for better understanding the penetration of the microwave signal into the forest canopy

  14. The impact of food manufacturing practices on food borne diseases

    Directory of Open Access Journals (Sweden)

    Cristina Paiva de Sousa

    2008-08-01

    Full Text Available Food-borne illness is a major international problem and an important cause of reduced economic growth. The contamination of the food supply with the pathogens and its persistence, growth, multiplication and/or toxin production has emerged as an important public health concern. Most of these problems could be controlled with the efforts on the part of the food handlers, whether in a processing plant, a restaurant, and others. In contrast with most chemical hazardous compounds, the concentration of food pathogens changes during the processing, storage, and meal preparation, making it difficult to estimate the number of the microorganisms or the concentration of their toxins at the time of ingestion by the consumer. This review shows main microorganisms related to the manipulation practices such as Staphylococcus spp., Escherichia coli and Salmonella spp. and describes the factors regarding the food-borne illness highlighting the impact of good manipulation practices on the food safety and food quality.Doenças veiculadas por alimentos são um dos maiores problemas de Saúde Pública no mundo, sendo responsáveis por reduções no crescimento econômico global. A contaminação de alimentos com patógenos e sua persistência, crescimento, multiplicação e/ou produção de toxinas é de interesse da Saúde Pública. Estes problemas podem ser controlados com esforços e treinamento constante de manipuladores de alimentos. Em contraste com perigos químicos e físicos, a concentração de patógenos em alimentos é modificada durante etapas de processamento, acondicionamento e preparação, tornando difícil estimar e quantificar o número de microrganismos ou a concentração de suas toxinas no momento da ingestão do alimento. Esta revisão comenta sobre os principais microrganismos bacterianos relacionados à práticas de manipulação como Staphylococcus spp., Escherichia coli e Salmonella spp. ressaltando o consumo de alimentos em ruas, o

  15. Strangers in Paradise: The Life and Literature of Foreign-Born Women in California.

    Science.gov (United States)

    Friedman, Adele C.

    This paper presents student research from a class project on the Life and Literature of Foreign-Born Women in California. It examines the role of these women in agriculture, the arts, and political and economic life. Specific accounts of women from Russia, Poland, France, and Mexico are given. Others mentioned include those women born in America…

  16. Do ewes born with a male co-twin have greater longevity with lambing over time?

    Science.gov (United States)

    Based on a recent analysis of historical records, ewes born co-twin to a ram had greater lifetime reproductive performance than ewes born co-twin to a ewe. We are interested in determining what component(s) of lifetime reproductive performance may be associated with a ewe’s co-twin sex. As an initi...

  17. Can a Web-Based Course Improve Communicative Competence of Foreign-Born Nurses?

    Science.gov (United States)

    Van Schaik, Eileen; Lynch, Emily M.; Stoner, Susan A.; Sikorski, Lorna D.

    2014-01-01

    In the years since World War II, the United States has grown increasingly dependent on foreign-born healthcare personnel at all levels of the healthcare system. Foreign-born nurses report that while they may feel clinically competent, they often feel unprepared for the use of English in the healthcare setting (Davis & Nichols, 2002; Guttman,…

  18. Testing Born's rule in quantum mechanics for three mutually exclusive events

    DEFF Research Database (Denmark)

    Sollner, Immo Nathanael; Gschösser, Benjamin; Mai, Patrick

    2012-01-01

    We present a new experimental approach using a three-path interferometer and find a tighter empirical upper bound on possible violations of Born's Rule. A deviation from Born's rule would result in multi-order interference. Among the potential systematic errors that could lead to an apparent viol...

  19. Feasibility of pulse oximetry for assessment of infants born in community based midwifery care

    NARCIS (Netherlands)

    Smit, M.; Ganzeboom, A.; Dawson, J.A.; Walther, F.J.; Bustraan, J.; van Roosmalen, Jos; te Pas, A.B.

    2014-01-01

    To evaluate the feasibility of using pulse oximetry (PO) for evaluating infants born in community-based midwifery care. Design: a prospective, observational study of infants born after midwifery supervised (home) births. Setting: 27 midwives from seven practices providing primary care in (home)

  20. The Acculturation Experiences of Foreign-Born Students of Color in Physics

    Science.gov (United States)

    Fries-Britt, Sharon; George Mwangi, Chrystal A.; Peralta, Alicia M.

    2014-01-01

    This study focuses on 15 foreign-born students majoring in physics who are also racial/ethnic minorities. We address the research question: What are the acculturation experiences of foreign-born Students of Color majoring in physics? Berry's (2003) theory of acculturation and Bandura's (1994) theory of self-efficacy were substantive…