WorldWideScience

Sample records for mpe

  1. MPE inference in conditional linear gaussian networks

    DEFF Research Database (Denmark)

    Salmerón, Antonio; Rumí, Rafael; Langseth, Helge

    2015-01-01

    Given evidence on a set of variables in a Bayesian network, the most probable explanation (MPE) is the problem of finding a configuration of the remaining variables with maximum posterior probability. This problem has previously been addressed for discrete Bayesian networks and can be solved using...

  2. Distributed caching mechanism for various MPE software services

    CERN Document Server

    Svec, Andrej

    2017-01-01

    The MPE Software Section provides multiple software services to facilitate the testing and the operation of the CERN Accelerator complex. Continuous growth in the number of users and the amount of processed data result in the requirement of high scalability. Our current priority is to move towards a distributed and properly load balanced set of services based on containers. The aim of this project is to implement the generic caching mechanism applicable to our services and chosen architecture. The project will at first require research about the different aspects of distributed caching (persistence, no gc-caching, cache consistency etc.) and the available technologies followed by the implementation of the chosen solution. In order to validate the correctness and performance of the implementation in the last phase of the project it will be required to implement a monitoring layer and integrate it with the current ELK stack.

  3. Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications.

    Science.gov (United States)

    Balaji, Arunpandian; Jaganathan, Saravana Kumar; Supriyanto, Eko; Muhamad, Ida Idayu; Khudzari, Ahmad Zahran Md

    2015-01-01

    Developing multifaceted, biocompatible, artificial implants for tissue engineering is a growing field of research. In recent times, several works have been reported about the utilization of biomolecules in combination with synthetic materials to achieve this process. Accordingly, in this study, the ability of an extract obtained from Aloe vera, a commonly used medicinal plant in influencing the biocompatibility of artificial material, is scrutinized using metallocene polyethylene (mPE). The process of coating dense fibrous Aloe vera extract on the surface of mPE was carried out using microwaves. Then, several physicochemical and blood compatibility characterization experiments were performed to disclose the effects of corresponding surface modification. The Fourier transform infrared spectrum showed characteristic vibrations of several active constituents available in Aloe vera and exhibited peak shifts at far infrared regions due to aloe-based mineral deposition. Meanwhile, the contact angle analysis demonstrated a drastic increase in wettability of coated samples, which confirmed the presence of active components on glazed mPE surface. Moreover, the bio-mimic structure of Aloe vera fibers and the influence of microwaves in enhancing the coating characteristics were also meticulously displayed through scanning electron microscopy micrographs and Hirox 3D images. The existence of nanoscale roughness was interpreted through high-resolution profiles obtained from atomic force microscopy. And the extent of variations in irregularities was delineated by measuring average roughness. Aloe vera-induced enrichment in the hemocompatible properties of mPE was established by carrying out in vitro tests such as activated partial thromboplastin time, prothrombin time, platelet adhesion, and hemolysis assay. In conclusion, the Aloe vera-glazed mPE substrate was inferred to attain desirable properties required for multifaceted biomedical implants.

  4. Forskel i naturværdi mellem områder med og uden Japansk Pileurt, Kæmpe Pileurt og Rynket Rose i Aarhus Kommune

    DEFF Research Database (Denmark)

    Nielsen, Steffen Larni; Madsen, Bjarke

    2015-01-01

    Invasive arter blandt andre Japansk Pileurt, Kæmpe Pileurt og Rynket Rose, har Aarhus Kommune et særligt fokus på. Vi undersøgte floristiske forskelle mellem lokaliteter med og uden de nævnte invasive plantearter. Vi fandt, at artsrigdom og naturværdi er lavere, samt en anderledes artssammensætning...

  5. Calibration of hard x-ray (15 - 50 keV) optics at the MPE test facility PANTER

    Science.gov (United States)

    Bräuninger, Heinrich; Burkert, Wolfgang; Hartner, Gisela D.; Citterio, Oberto; Ghigo, Mauro; Mazzoleni, Francesco; Pareschi, Giovanni; Spiga, Daniele

    2004-02-01

    The Max-Planck-Institut für extraterrestrische Physik (MPE) in Garching, Germany, operates the large X-ray beam line facility PANTER for testing astronomical systems. At PANTER a number of telescopes like EXOSAT, ROSAT, SAX, JET-X, ABRIXAS, XMM and SWIFT operating in the soft energy range (0.02 - 15 keV) have been successfully calibrated. In the present paper we report on an important upgrade recently implemented that enables the calibration of hard X-ray optics (from 15 up to 50 keV). Currently hard X-ray optics based on single and multilayer coating are being developed for several future X-ray missions. The hard X-ray calibrations at PANTER are carried out by a high energy source based on an electron gun and several anodes, able to cover the energy range from 4.5 up to 50 keV. It provides fluxes up to 104 counts/sec/cm2 at the instrument chamber with a stability better than 1%. As detector a pn-CCD camera operating between 0.2 and 50 keV and a collecting area of 36 cm2 is used. Taking into account the high energy resolution of the CCD (145 eV at 6 keV), a very easy way to operate the facility in hard X-ray is in energy-dispersive mode (i.e. with a broad-band beam). A double crystal monochromator is also available providing energies up to 20 keV. In this paper we present the first results obtained by using PANTER for hard X-ray characterizations, performed on prototype multilayer optics developed by the Osservatorio Astronomico di Brera (OAB), Milano, Italy, and the Harvard-Smithsonian Center for Astrophysics (CfA), Cambridge, MA, USA.

  6. Prevention and health promotion from theory to practice: The interprofessional MeMPE Summer University for students of Medicine, Master of Public Health and Epidemiology

    Directory of Open Access Journals (Sweden)

    Idler, Nadja

    2016-11-01

    Full Text Available Objective: During the 2015 summer semester of Munich’s Ludwig Maximilian University (LMU medical school, the pilot project “MeMPE Summer University – An Interprofessional Seminar on Prevention and Health Promotion” was implemented as a compulsory elective subject. In 90 teaching units of 45 minutes each, 20 students from the degree programs of Medicine, Master of Public Health and Master of Science Epidemiology (MeMPE completed modules in theoretical introduction, scientific project work as well as practical assignments and conference attendance.Methods: The project was evaluated by students using pre- and post-project questionnaires (26 and 57 items, evaluated on a Five-level Likert scale of 1=“fully agree” to 5=“fully disagree”. The evaluation interviews of the instruction participants were recorded, transcribed and analyzed according to Mayring’s qualitative content analysis.Results: Questionnaire response rate was 100 %. In pre/post comparison, the students reported an improvement in factual knowledge (pre median=3.0; post median=2.0; p<0.0001, in scientific work (pre median=3.0; post median=1.0; p<0.0001 and in interprofessional work (pre median=2.0; post median=1.0; p=0.024. In 18 interviews, the instructors largely expressed their motivation to participate in the project again.Conclusion: The MeMPE Summer University can serve as an example of best practice for interprofessional communication of prevention and health-promotion topics in theory and practice. The evaluation results show that the project enjoyed a high level of acceptance among students and instructors, and that it should be conducted in a revised version again in 2016.

  7. O perfil da relação profissional entre as empresas de serviços contábeis (ESC) e a micro e a pequena empresa (MPE)

    OpenAIRE

    Palma, Daniel Azevedo

    2005-01-01

    Neste trabalho, além do referencial teórico, envolvendo conceitos e classificações da MPE, e também da Contabilidade, realizou-se uma pesquisa de campo na cidade de Unaí -MG, em que se procurou identificar as principais características existentes na relação profissional entre as Empresas de Serviços Contábeis (ESC) e a Micro e Pequena Empresa (MPE) e verificar como as informações geradas pelas ESCs podem ser mais bem utilizadas na gestão das MPEs. Obteve-se uma amostra corroborando a caracter...

  8. A consultoria em gestão realizada pelo contabilista como alternativa de redução da mortalidade das MPE

    Directory of Open Access Journals (Sweden)

    Juarez Domingues Carneiro

    2005-03-01

    Full Text Available Este artigo tem por finalidade demonstrar que é possível reduzir a alta taxa de mortalidade das Micro e Pequenas Empresas no Brasil, na ordem de quase 50% nos dois primeiros anos, por meio da consultoria especializada em gestão, realizada por profissionais da contabilidade. O estudo tem como um de seus pilares, o estabelecimento de uma relação entre a Teoria Geral dos Sistemas e o Sistema de Gestão das Micro e Pequenas Empresas (MPE, tendo como seu subsistema principal a Consultoria em Gestão pelo Contabilista. O artigo ao mesmo tempo em que evidencia a presença constante do profissional da contabilidade nas MPE, desde o seu surgimento, também identifica uma série de causas que levam a essa mortalidade, principalmente na área de gestão, trazendo uma proposta de alternativa de redução de tal problemática, por intermédio, especialmente, da formação continuada do profissional da área contábil. This artide aims to show that it is possible to reduce the high mortality rate ofMicro and 5mall Enterprises (M5Es in Brazil, reaching almost 50% in the twofirst years, by means of consultancy, specialized in Gestion, given byaccounting professionals. One of the main fundaments of this study is theestablishment of a relationship between 5ystems General Theory and Gestion5ystem of Micro and 5mall Enterprises having as its most relevant subsystems,the Gestion Consultancy by the Accountant. Besides highlighting the frequentpresence of the Accounting Professional in the M5Es since those were firstcreated, this artide also identities series of causes that lead to theirmortality, mainly in the Gestion Area, bringing an alternative proposal ofreducing such a problem, especially through the continued education of theaccounting area professional.

  9. Posicionamento estratégico de MPE'S com base na inovação através do modelo Hélice Tríplice

    Directory of Open Access Journals (Sweden)

    Dusan Schreiber

    Full Text Available A globalização dos mercados, os avanços da ciência e da tecnologia, estimulou o surgimento de novos nichos de mercado, com consumidores mais exigentes, e, também, o aumento da competitividade entre empresas (ORTIZ, 2003. Nesse panorama, destacam-se as micro e pequenas empresas - MPE's, que se responsabilizam por parcela relevante de geração de oportunidades de emprego e de renda no país. No entanto,estudos apontam para a fragilidade técnica e produtiva das MPE'sque se reflete em índices mais elevados de encerramento de operações e de inadimplência de obrigações sociais e tributárias (SEBRAE, 2009. Esses agentes econômicos, por vezes menos preparados para competir, mas essenciais para o sistema econômico e social dos países, foram contemplados com políticas públicas, voltadas para o estímulo ao empreendedorismo, priorizando a capacitação em gestão e métodos de produção (CASSIOLATO & LASTRES, 2001. Dentre elas destacam-se a constituição de redes colaborativas de MPE's, a capacitação de seus gestores e equipes operacionais, além da disponibilização de acesso ao conhecimento técnico, com vistas a subsidiar a atividade de inovação de produtos e processos (MATTOS et al., 2009. Com o objetivo de otimizar a alocação de recursos públicos para o referido fim, os agentes governamentais optam pela adoção do modelo de Hélice Tríplice, por meio do qual o governo media a interação entre a academia e as empresas e fomenta o compartilhamento da infra-estrutura universitária, dos conhecimentos, métodos e técnicas, desde a gestão até a operação. O objetivo deste trabalho visa evidenciar as características do posicionamento estratégico de empresas de pequeno porte, que participam de duas redes de cooperação, atuantes na região sul do país, com destaque para o processo de concepção de estratégias individuais e coletivas construídas com base em programas de capacitação em inovação, de produtos e

  10. Depositional System Transition from Braided River to Tide Dominated Delta-A Case Study of the MPE3 Block in the Eastern Venezuelan Basin

    Science.gov (United States)

    Huang, Wensong; Chen, Heping; Xu, Fang; Meng, Zheng; Li, Yonghao

    2017-04-01

    The Eastern Venezuelan basin is a world-class petroliferous area, with the sedimentary environment controlled by the interaction between the Caribbean plate and the American plate. Based on interpretation of 3D seismic data, description of electrical well-logging facies and analysis of the sedimentary phenomena on the cores, we distinguished different types of sedimentary associations and clarified the evolution progress of the sedimentary system in the study area, the MPE3 Block. We put forward that depositional system in the study area changed from braided river in the early Miocene to tide dominated delta in the middle Miocene. Paralleled with sedimentary progress, the depositional hydrodynamic mechanism altered from the inertia dominated setting into the buoyancy dominated setting. During the middle Miocene, the tidal effect obviously reworked and formed tidal bars and tidal channels, both severing as the sedimentary framework. From the perspective of the tectonic movement, the study area varied from the foreland stage during the early Miocene to the compression and inverse stage during the middle Miocene. At the same time, the study area located in the southern part of the foreland basin began to extend and marine transgression occurred due to the tectonic extensional movement. We pointed out that critical factors influencing the transition from braided river to tidal dominate delta include palaeogeomorphology, sea level fluctuation, feeder system and the distance to catchment area.

  11. (and Sound) of SiMPE

    DEFF Research Database (Denmark)

    Erkut, Cumhur; Jylhä, Antti; Serafin, Stefania

    application stores. As proposed in the ACM Curriculum report, these application domains are attractive in education, especially in computer science and interaction design. The main question is how to systematically integrate the rapidly evolving knowledge, know-how, tools, and techniques of mobile (audio......) programming and interaction design into university curricula. In this paper, we provide an account of our own development and teaching experience. We highlight the outcomes, which are exploratory applications challenging the state-of-the-art in mobile application development based on non-speech sound...

  12. MPA/ESO/MPE/USM Joint Astronomy Conference

    CERN Document Server

    Böhringer, H; Finoguenov, A; Schuecker, P; Heating versus Cooling in Galaxies and Clusters of Galaxies

    2007-01-01

    The present volume is the record of a recent topical conference on the interplay between heating and cooling processes in galaxies and clusters of galaxies. The volume documents recent progress in our understanding of the dense central regions of these objects. Chapters detail recent results from multiwavelength observations and advances in numerical hydrodynamical simulations. An additional section covers new research on feedback and self-regulatory mechanisms during cosmic structure formation in general, and in galaxy formation in particular. With reviews and technical papers written by leading scientists, this state-of-the art report will be a valuable and comprehensive source of reference for all astronomers and astrophysicists active in this field.

  13. Exportações brasileiras: fatores explicativos da participação das micro e pequenas empresas (MPE)

    OpenAIRE

    Fernando Martinson Ruiz

    2005-01-01

    As micro e pequenas empresas (MPEs), foco desta pesquisa, apresentam características peculiares em comparação às empresas de maior porte. O número de MPEs brasileiras, industriais e exportadoras vem aumentando nos últimos anos, assim como a continuidade de suas atividades exportadoras, configurando um novo panorama para este tipo de empresas. A participação destas empresas no volume de exportação total do país ainda é muito pequena (aproximadamente 2,4%, em 2003), para padrões internacionais ...

  14. Growing Black Holes: Accretion in a Cosmological Context Proceedings of the MPA/ESO/MPE/USM Joint Astronomy Conference Held at Garching, Germany, 21-25 June 2004

    CERN Document Server

    Merloni, Andrea; Sunyaev, Rashid A

    2005-01-01

    Supermassive black holes are now believed to play an important role in the evolution of the Universe. Every respectable galaxy hosts in its center a black hole that appears to regulate the growth of the galaxy itself. In this book, leading experts in the field review the most recent theoretical and observational results on the following topics: * formation and growth of the first black holes in the Universe and their role in the formation and evolution of galaxies * the physics of black-hole accretion and the production of relativistic jets * binary black-hole mergers and gravitational radiation. Theoretical work is supplemented by the most recent exciting results from space and ground based observatories. This volume is useful research and reference tool for the entire astrophysical community.

  15. Benchmarking of multiple preequilibrium routines in GNASH

    International Nuclear Information System (INIS)

    Chadwick, M.B.; Young, P.G.

    1994-08-01

    The authors compare two different models for multiple preequilibrium emission (MPE) in GNASH: the older exciton MPE model; and a new generalized MPE model which is parameter-free. They analyze the proton-induced reactions on zirconium and lead, which were the focus of a recent NEA intermediate-energy code intercomparison, using both the MPE models. They find that the new generalized MPE model better describes the measurements

  16. Market Power Europe

    DEFF Research Database (Denmark)

    Kelstrup, Jesper Dahl

    2015-01-01

    Market Power Europe (MPE) constitutes an important contribution to the literature on the global role and actorness of the EU. In order to develop MPE as a theory, this contribution provides an assessment of how Russia, the USA and China have converged towards three EU trade policies in 2013....... The analysis finds that MPE fails to account for important dynamics related to externalization in the three cases. In order to improve MPE analytically, the article suggests that MPE should include three intervening variables to account for the EU’s ability to externalize its policies and act as MPE...

  17. Motivation toward Physical Exercise and Subjective Wellbeing: The Mediating Role of Trait Self-Control

    Directory of Open Access Journals (Sweden)

    Walid Briki

    2016-10-01

    Full Text Available Motivation toward physical exercise (MPE and trait self-control (TSC were identified as key predictors of subjective wellbeing (SWB. However, there has not been any research designed to examine the mediating role of TSC in the relationship between MPE and SWB. The present study utilizes self-determination theory, control-process theory of self-regulation, and theory of multiple pathways of TSC in order to examine whether TSC mediates the relationships of autonomous MPE (A-MPE, controlled MPE (C-MPE, and impersonal MPE (NO-MPE with SWB using structural equation modeling (XLSTAT PLS. Three hundred seventeen adult American individuals (Mage = 32.97, SDage = 11.30, who reported to be regular exercisers, voluntarily answered questionnaires assessing MPE, TSC, and SWB. Correlational analyses revealed positive relationships between A-MPE, TSC, and SWB, and negative relationships of C-MPE and NO-MPE with TSC and SWB. Mediation analyses revealed that TSC mediated the relationships of A-MPE (partial mediation and C-MPE (full mediation with SWB, but did not mediate the relationship between NO-MPE and SWB. The estimates of the quality of the hypothesized model were acceptable (outer model GoF = .935; absolute GoF = .330; relative GoF = .942; inner model GoF = 1.008; R2 = 36.947%. Finally, this study supports the view that MPE can influence SWB through TSC, and incites to pursue the examination of the relationships between self-determined motivation, self-regulation mechanisms, and health-related outcomes.

  18. The malignant pleural effusion as a model to investigate intratumoral heterogeneity in lung cancer.

    Directory of Open Access Journals (Sweden)

    Saroj K Basak

    Full Text Available Malignant Pleural Effusions (MPE may be useful as a model to study hierarchical progression of cancer and/or intratumoral heterogeneity. To strengthen the rationale for developing the MPE-model for these purposes, we set out to find evidence for the presence of cancer stem cells (CSC in MPE and demonstrate an ability to sustain intratumoral heterogeneity in MPE-primary cultures. Our studies show that candidate lung CSC-expression signatures (PTEN, OCT4, hTERT, Bmi1, EZH2 and SUZ12 are evident in cell pellets isolated from MPE, and MPE-cytopathology also labels candidate-CSC (CD44, cMET, MDR-1, ALDH subpopulations. Moreover, in primary cultures that use MPE as the source of both tumor cells and the tumor microenvironment (TME, candidate CSC are maintained over time. This allows us to live-sort candidate CSC-fractions from the MPE-tumor mix on the basis of surface markers (CD44, c-MET, uPAR, MDR-1 or differences in xenobiotic metabolism (ALDH. Thus, MPE-primary cultures provide an avenue to extract candidate CSC populations from individual (isogenic MPE-tumors. This will allow us to test whether these cells can be discriminated in functional bioassays. Tumor heterogeneity in MPE-primary cultures is evidenced by variable immunolabeling, differences in colony-morphology, and differences in proliferation rates of cell subpopulations. Collectively, these data justify the ongoing development of the MPE-model for the investigation of intratumoral heterogeneity, tumor-TME interactions, and phenotypic validation of candidate lung CSC, in addition to providing direction for the pre-clinical development of rational therapeutics.

  19. Mucuna pruriens Linn. seed extract pretreatment protects against cardiorespiratory and neuromuscular depressant effects of Naja sputatrix (Javan spitting cobra) venom in rats.

    Science.gov (United States)

    Fung, Shin Yee; Tan, Nget Hong; Sim, Si Mui; Marinello, Enrico; Guerranti, Roberto; Aguiyi, John Chinyere

    2011-04-01

    Mucuna pruriens has been used by native Nigerians as a prophylactic for snakebite. The protective effects of M. pruriens seed extract (MPE) were investigated against the pharmacological actions of N. sputatrix (Javan spitting cobra) venom in rats. The results showed that MPE-pretreatment protected against cardiorespiratory and, to a lesser extent, neuromuscular depressant effects of N. sputatrix venom. These may be explained at least in part by the neutralisation of the cobra venom toxins by anti-MPE antibodies elicited by the MPE pretreatment.

  20. Intrapleural cisplatin for management of malignant pleural effusion in a patient with plasma cell leucaemia.

    Science.gov (United States)

    Agarwal, Abhishek; Klair, Jagpal; Patolia, Setu; Meena, Nikhil K

    2015-06-29

    Plasma cell leucaemia (PCL) is a rare aggressive form of multiple myeloma. It occasionally involves the pleura, causing malignant pleural effusion (MPE). MPE presents a management dilemma for physicians, given the different treatment options available with varying efficacy and side effects. We report a case of a 64-year-old man with MPE due to PCL, successfully managed with intrapleural cisplatin and a tunnelled pleural catheter. We believe this to be the first report of management of PCL-associated MPE with intrapleural cisplatin. 2015 BMJ Publishing Group Ltd.

  1. Recursive Lexicographical Search

    DEFF Research Database (Denmark)

    Iskhakov, Fedor; Rust, John; Schjerning, Bertel

    2016-01-01

    of Bertrand price competition with cost reducing investments which we show is a DDG. We provide an exact non- iterative algorithm that finds all MPE of every stage game, and prove there can be only 1, 3 or 5 of them. Using the stage games as building blocks, RLS rapidly finds and enumerates all MPE...

  2. Multiprofessional education to stimulate collaboration: a circular argument and its consequences.

    Science.gov (United States)

    Roodbol, Petrie F

    2010-01-01

    The current developments in healthcare are unprecedented. The organization of health care is complex. Collaboration is essential to meet all the healthcare needs of patients and to achieve coordinated and unambiguous information. Multiprofessional education (MPE) or multidisciplinary training (MDT) seems a logical step to stimulate teamwork. However, collaboration and MPE are wrestling with the same problems: social identity and acceptance.

  3. Multiprofessional education to stimulate collaboration: a circular argument and its consequences [

    Directory of Open Access Journals (Sweden)

    Roodbol, Petrie F.

    2010-04-01

    Full Text Available [english] The current developments in healthcare are unprecedented. The organization of health care is complex. Collaboration is essential to meet all the healthcare needs of patients and to achieve coordinated and unambiguous information. Multiprofessional education (MPE or multidisciplinary training (MDT seems a logical step to stimulate teamwork. However, collaboration and MPE are wrestling with the same problems: social identity and acceptance.

  4. Exorcising the ghost of the past: The abandonment of obsession ...

    African Journals Online (AJOL)

    This article examines how Phaswane Mpe's post-apartheid novel, Welcome to Our Hillbrow (2000), responds to Njabulo Ndebele's idea of “rediscovering the ordinary”. This is probed through analyses of themes, characterization and style. It will be argued that, through Welcome to Our Hillbrow, Mpe makes a call for ...

  5. Transient changes in milk production efficiency and bacterial community composition resulting from near-total exchange of ruminal contents between high- and low-efficiency Holstein cows

    Science.gov (United States)

    The objectives of this study were to determine if milk production efficiency (MPE) is altered by near-total exchange of ruminal contents between high- (HE) and low-MPE (LE) cows and to characterize ruminal bacterial community composition (BCC) prior to exchange and over time post-exchange. Three pai...

  6. CNN - en succes i krise

    DEFF Research Database (Denmark)

    Böss, Michael

    1994-01-01

    Om CNN og den krise, netværket hele tiden må bekæmpe og dække. Udgivelsesdato: 26. september......Om CNN og den krise, netværket hele tiden må bekæmpe og dække. Udgivelsesdato: 26. september...

  7. Nutritional and sensory quality evaluation of sponge cake prepared by incorporation of high dietary fiber containing mango (Mangifera indica var. Chokanan) pulp and peel flours.

    Science.gov (United States)

    Aziah, A A Noor; Min, W Lee; Bhat, Rajeev

    2011-09-01

    Sponge cake prepared by partial substitution of wheat flour with mango pulp and mango peel flours (MPuF and MPeF, respectively) at different concentrations (control, 5%, 10%, 20% or 30%) were investigated for the physico-chemical, nutritional and organoleptic characteristics. Results showed sponge cake incorporated with MPuF and MPeF to have high dietary fiber with low fat, calorie, hydrolysis and predicted glycemic index compared with the control. Increasing the levels of MPuF and MPeF in sponge cake had significant impact on the volume, firmness and color. Sensory evaluation showed sponge cake formulated with 10% MPuF and 10% MPeF to be the most acceptable. MPeF and MPuF have high potential as fiber-rich ingredients and can be utilized in the preparation of cake and other bakery products to improve the nutritional qualities.

  8. Mission to planet earth: A call to repeal the Landsat Act

    International Nuclear Information System (INIS)

    Gabrynowicz, J.I.; Wood, C.A.

    1991-01-01

    Mission to Planet Earth (MPE) is being planned to provide scientists with data and information about global climate change so that policymakers can make informed decisions in directing the nation's response to the change. A crucial component of MPE is the Landsat system and the continuous, multidecade database it has produced. Yet because of an ill-conceived and poorly-executed commercialization policy, MPE researchers are being deprived of these vital national assets, profoundly hampering their ability to carry out the work of MPE. Effects of the US commercialization policy have reached abroad. The French, Japanese, and Canadians, following the US lead, have also commercialized their existing and future land remote sensing systems - further inhibiting the free flow of data among these complementary systems and preventing a truly international, scientific effort in MPE. Meeting the challenges of global climate change requires reconsidering the proper role of the Landsat system and identifying appropriate and inappropriate commercial remote sensing activities

  9. The Exploration of Peptide Biomarkers in Malignant Pleural Effusion of Lung Cancer Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Jing Xu

    2017-01-01

    Full Text Available Background. Diagnoses of malignant pleural effusion (MPE are a crucial problem in clinics. In our study, we compared the peptide profiles of MPE and tuberculosis pleural effusion (TPE to investigate the value of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS in diagnosis of MPE. Material and Methods. The 46 MPE and 32 TPE were randomly assigned to training set and validation set. Peptides were isolated by weak cation exchange magnetic beads and peaks in the m/z range of 800–10000 Da were analyzed. Comparing the peptide profile between 30 MPE and 22 TPE samples in training set by ClinProTools software, we screened the specific biomarkers and established a MALDI-TOF-MS classification of MPE. Finally, the other 16 MPE and 10 TPE were included to verify the model. We additionally determined carcinoembryonic antigen (CEA in MPE and TPE samples using electrochemiluminescent immunoassay method. Results. Five peptide peaks (917.37 Da, 4469.39 Da, 1466.5 Da, 4585.21 Da, and 3216.87 Da were selected to separate MPE and TPE by MALDI-TOF-MS. The sensitivity, specificity, and accuracy of the classification were 93.75%, 100%, and 96.15%, respectively, after blinded test. The sensitivity of CEA was significantly lower than MALDI-TOF-MS classification (P=0.035. Conclusions. The results indicate MALDI-TOF-MS is a potential method for diagnosing MPE.

  10. Beneficial impact of CCL2 and CCL12 neutralization on experimental malignant pleural effusion.

    Directory of Open Access Journals (Sweden)

    Antonia Marazioti

    Full Text Available Using genetic interventions, we previously determined that C-C motif chemokine ligand 2 (CCL2 promotes malignant pleural effusion (MPE formation in mice. Here we conducted preclinical studies aimed at assessing the specific therapeutic potential of antibody-mediated CCL2 blockade against MPE. For this, murine MPEs or skin tumors were generated in C57BL/6 mice by intrapleural or subcutaneous delivery of lung (LLC or colon (MC38 adenocarcinoma cells. Human lung adenocarcinoma cells (A549 were used to induce MPEs in severe combined immunodeficient mice. Intraperitoneal antibodies neutralizing mouse CCL2 and/or CCL12, a murine CCL2 ortholog, were administered at 10 or 50 mg/kg every three days. We found that high doses of CCL2/12 neutralizing antibody treatment (50 mg/kg were required to limit MPE formation by LLC cells. CCL2 and CCL12 blockade were equally potent inhibitors of MPE development by LLC cells. Combined CCL2 and CCL12 neutralization was also effective against MC38-induced MPE and prolonged the survival of mice in both syngeneic models. Mouse-specific CCL2-blockade limited A549-caused xenogeneic MPE, indicating that host-derived CCL2 also contributes to MPE precipitation in mice. The impact of CCL2/12 antagonism was associated with inhibition of immune and vascular MPE-related phenomena, such as inflammation, new blood vessel assembly and plasma extravasation into the pleural space. We conclude that CCL2 and CCL12 blockade are effective against experimental MPE induced by murine and human adenocarcinoma in mice. These results suggest that CCL2-targeted therapies may hold promise for future use against human MPE.

  11. Molecular pathological epidemiology: new developing frontiers of big data science to study etiologies and pathogenesis.

    Science.gov (United States)

    Hamada, Tsuyoshi; Keum, NaNa; Nishihara, Reiko; Ogino, Shuji

    2017-03-01

    Molecular pathological epidemiology (MPE) is an integrative field that utilizes molecular pathology to incorporate interpersonal heterogeneity of a disease process into epidemiology. In each individual, the development and progression of a disease are determined by a unique combination of exogenous and endogenous factors, resulting in different molecular and pathological subtypes of the disease. Based on "the unique disease principle," the primary aim of MPE is to uncover an interactive relationship between a specific environmental exposure and disease subtypes in determining disease incidence and mortality. This MPE approach can provide etiologic and pathogenic insights, potentially contributing to precision medicine for personalized prevention and treatment. Although breast, prostate, lung, and colorectal cancers have been among the most commonly studied diseases, the MPE approach can be used to study any disease. In addition to molecular features, host immune status and microbiome profile likely affect a disease process, and thus serve as informative biomarkers. As such, further integration of several disciplines into MPE has been achieved (e.g., pharmaco-MPE, immuno-MPE, and microbial MPE), to provide novel insights into underlying etiologic mechanisms. With the advent of high-throughput sequencing technologies, available genomic and epigenomic data have expanded dramatically. The MPE approach can also provide a specific risk estimate for each disease subgroup, thereby enhancing the impact of genome-wide association studies on public health. In this article, we present recent progress of MPE, and discuss the importance of accounting for the disease heterogeneity in the era of big-data health science and precision medicine.

  12. Multiple Payload Ejector for Education, Science and Technology Experiments

    Science.gov (United States)

    Lechworth, Gary

    2005-01-01

    The education research community no longer has a means of being manifested on Space Shuttle flights, and small orbital payload carriers must be flown as secondary payloads on ELV flights, as their launch schedule, secondary payload volume and mass permits. This has resulted in a backlog of small payloads, schedule and cost problems, and an inability for the small payloads community to achieve routine, low-cost access to orbit. This paper will discuss Goddard's Wallops Flight Facility funded effort to leverage its core competencies in small payloads, sounding rockets, balloons and range services to develop a low cost, multiple payload ejector (MPE) carrier for orbital experiments. The goal of the MPE is to provide a low-cost carrier intended primarily for educational flight research experiments. MPE can also be used by academia and industry for science, technology development and Exploration experiments. The MPE carrier will take advantage of the DARPAI NASA partnership to perform flight testing of DARPA s Falcon small, demonstration launch vehicle. The Falcon is similar to MPE fiom the standpoint of focusing on a low-cost, responsive system. Therefore, MPE and Falcon complement each other for the desired long-term goal of providing the small payloads community with a low-cost ride to orbit. The readiness dates of Falcon and MPE are complementary, also. MPE is being developed and readied for flight within 18 months by a small design team. Currently, MPE is preparing for Critical Design Review in fall 2005, payloads are being manifested on the first mission, and the carrier will be ready for flight on the first Falcon demonstration flight in summer, 2006. The MPE and attached experiments can weigh up to 900 lb. to be compatible with Falcon demonstration vehicle lift capabilities fiom Wallops, and will be delivered to the Falcon demonstration orbit - 100 nautical mile circular altitude.

  13. Palliative Treatment of Malignant Pleural Effusion

    Directory of Open Access Journals (Sweden)

    Chenyang Liu

    2015-01-01

    Full Text Available Malignant pleural effusion (MPE is a common clinical problem caused by cancers. Pleural effusion can be the first sign of cancer in more than 25% of patients. Lung cancer and breast cancer are the most common cancers that metastasize to the pleura in men and women, respectively. Other cancers, including, but not limited to, lymphomas, ovarian cancer, stomach cancer, and several unknown primary cancers can also lead to MPE. Dyspnea and chest pain are the most common symptoms of MPE along with other symptoms such as a cough, weight loss, anorexia, fatigue, and weakness. Aggravation of these symptoms is closely related to the rate of accumulation of pleural effusion. Treatment options to MPE are determined by the type and extent of the underlying malignancy. The major goals of the treatment are to relieve symptoms, restore functions, improve the quality of life, and minimize the duration of hospital stay and costs. Although some patients can be treated with systemic therapies, most of these treatments are temporary, and MPE would recur soon. Hence, further palliative treatments to effectively control pleural effusions and relieve symptoms are necessary. This review addresses the pathophysiology of MPE and the treatment options for patients with MPE.

  14. Expression Profile of Three Splicing Factors in Pleural Cells Based on the Underlying Etiology and Its Clinical Values in Patients with Pleural Effusion

    Directory of Open Access Journals (Sweden)

    A-Lum Han

    2018-02-01

    Full Text Available Splicing factors (SFs are involved in oncogenesis or immune modulation, the common underlying processes giving rise to pleural effusion (PE. The expression profiles of three SFs (HNRNPA1, SRSF1, and SRSF3 and their clinical values have never been assessed in PE. The three SFs (in pellets of PE and conventional tumor markers were analyzed using PE samples in patients with PE (N = 336. The sum of higher–molecular weight (Mw forms of HNRNPA1 (Sum-HMws-HNRNPA1 and SRSF1 (Sum-HMws-SRSF1 and SRSF3 levels were upregulated in malignant PE (MPE compared to benign PE (BPE; they were highest in cytology-positive MPE, followed by tuberculous PE and parapneumonic PE. Meanwhile, the lowest-Mw HNRNPA1 (LMw-HNRNPA1 and SRSF1 (LMw-SRSF1 levels were not upregulated in MPE. Sum-HMws-HNRNPA1, Sum-HMws-SRSF1, and SRSF3, but neither LMw-HNRNPA1 nor LMw-SRSF1, showed positive correlations with cancer cell percentages in MPE. The detection accuracy for MPE was high in the order of carcinoembryonic antigen (CEA, 85%, Sum-HMws-HNRNPA1 (76%, Sum-HMws-SRSF1 (68%, SRSF3, cytokeratin-19 fragments (CYFRA 21-1, LMw-HNRNPA1, and LMw-SRSF1. Sum-HMws-HNRNPA1 detected more than half of the MPE cases that were undetected by cytology and CEA. Sum-HMws-HNRNPA1, but not other SFs or conventional tumor markers, showed an association with longer overall survival among patients with MPE receiving chemotherapy. Our results demonstrated different levels of the three SFs with their Mw-specific profiles depending on the etiology of PE. We suggest that Sum-HMws-HNRNPA1 is a supplementary diagnostic marker for MPE and a favorable prognostic indicator for patients with MPE receiving chemotherapy.

  15. Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression.

    Science.gov (United States)

    Rana, Digvijay G; Galani, Varsha J

    2014-01-01

    The effects of antidepressant treatments have traditionally been discussed primarily in terms of effects on noradrenergic and serotonergic systems. Multiple lines of investigation have also explored the role of dopaminergic systems in mental depression. Seed of Mucuna pruriens Linn. (DC) (Leguminoseae) is well-known with dopaminergic action and has several therapeutic applications in folk medicine in curing or managing a wide range of diseases including Parkinsonism. To elucidate the anti-depressent profile and possible dopaminergic modulating action of M. pruriens seeds in various experimental models of depression. In the present study, antidepressant effect of the hydroalcoholic extract of the M. pruriens seeds (MPE) (100 and 200 mg/kg, p.o.) was investigated in the Forced Swimming Test (FST), Tail Suspension Test (TST), and Chronic Unpredictable Mild Stress (CUMS) test in mice. Further, dopaminergic interaction of same doses of MPE in the FST and TST were checked by the administration of a haloperidol (0.1 mg/kg, i.p.) and bromocriptine (2 mg/kg, i.p.) on the 7(th) day of MPE treatment. Effect of MPE on locomotor activity was also checked using actophotometer. MPE produced a significant reduction of the immobility time in the FST and TST. Further, antidepressant action of MPE was significantly inhibited by haloperidol and potentiated by bromocriptine in the FST and TST. 21 days of MPE treatment produced protection in CUMS as indicated by a significant increase of sucrose intake of stressed mice. Locomotor activities of mice were not significantly changed after 1 h and 7(th) day of the MPE treatment. The results of this study indicate that hydroalcoholic extract of MPE have antidepressant action, which may be mediated by an interaction with the dopaminergic system.

  16. Malignant pleural effusion cell blocks are substitutes for tissue in EML4-ALK rearrangement detection in patients with advanced non-small-cell lung cancer.

    Science.gov (United States)

    Zhong, J; Li, X; Bai, H; Zhao, J; Wang, Z; Duan, J; An, T; Wu, M; Wang, Y; Wang, S; Wang, J

    2016-12-01

    To evaluate the feasibility of malignant pleural effusions (MPE) as surrogate samples for the detection of echinoderm microtubule-associated protein-like4 (EML4)-anaplastic lymphoma kinase (ALK) and to investigate the prognostic and predictive value of EML4-ALK in MPE of non-small-cell lung cancer (NSCLC). One hundred and nine NSCLC patients were retrospectively analysed. EML4-ALK was identified using paraffin-embedded tumour cells in MPE samples by immunohistochemistry (IHC, Ventana) and confirmed by fluorescence using in situ hybridisation (FISH) and qRT-PCR. The EGFR mutation was determined by MPE, using denaturing high-performance liquid chromatography (DHPLC). A total of 5 out of 109 (4.58%) patients were identified as EML4-ALK rearrangement in MPE by IHC.; In addition to two metachronous samples, the consistency of MPE and tissue for EML4-ALK detection was 100% (21/21), and the sensitivity and specificity were 100% (2/2) and 100% (19/19), respectively. EML4-ALK rearrangement cases were confirmed by FISH and qRT-PCR; the sensitivity were both 100% (2/2) when compared with tissue, and it was 60% (3/5) and 100% (5/5), respectively, when compared with MPE by IHC. The overall response rate (ORR) was 100% (2/2) for patients with EML4-ALK in MPE. Moreover, the PFS of these patients appeared to be prolonged in chemotherapy (9.27 versus 6.53 and versus 4.67 months, P = 0.122), compared with the EGFR mutation and the EGFR/ALK double negative group, respectively. EML4-ALK rearrangement detection in malignant pleural effusions is a complementary method for EML4-ALK detection. VETANA and qRT-PCR are more appropriate for MPE detection. EML4-ALK rearrangement in pleural effusions has a predictive value for treatment. © 2016 John Wiley & Sons Ltd.

  17. A comparative study to evaluate factors that influence survival in multidisciplinary predialysis educated patients and “Crashlanders”

    Directory of Open Access Journals (Sweden)

    Khairulsadek Zukmin

    2017-01-01

    Full Text Available Integrated multidisciplinary predialysis education (MPE is usually provided to support and prepare the pre-end-stage renal disease (ESRD patients before the initiation of renal replacement therapy (RRT. However, the impact of MPE is not known in our population, which is comprised patients of Asian origins and recipients of a totally subsidized health-care system. This research compared the survival probability, sociodemographic, and clinical characteristics of MPE patients and non-MPE patients (or crashlanders. A retrospective cohort study was conducted to investigate ESRD patients who started RRT in Brunei Darussalam from January 2013 to December 2014. Data were extracted from the computerized clinical database and dialysis records. A total of 351 new cases of ESRD patients who started on hemodialysis during the study period were included in the study. The median age was 56.0 years, with a slight male preponderance (56.6%. The MPE group was significantly older (P = 0.001 and more likely to have a history of diabetes mellitus (P = 0.013, ischemic heart disease (P = 0.014, and hypertension (P = 0.016. Despite being older and having more comorbidities (P = 0.028, MPE patients have a better survival probability (P = 0.028 and a 34% decreased risk of dying. Of those who died, older age (P = 0.001, higher serum creatinine (P = 0.01, and lower hemoglobin level (P = 0.017 were significant prognostic indicators. MPE before the initiation of RRT contributed to greater survival probability in near ESRD patients. The survival benefits were evident despite the presence of inherent risks (older age and presence of comorbidities in the MPE population in comparison with the non-MPE cohort.

  18. [Evaluation of the diagnosis value of carcinoembryonic antigen in malignant pleural effusion].

    Science.gov (United States)

    Yu, Y X; Tong, Z H; Zhou, X X; Liang, L R; Wang, Z; Xu, L L; Wang, X J; Wu, Y B; Li, H J; Lu, Z

    2018-02-06

    Objective: To investigate the diagnostic value of serum and pleural fluid carcinoembryonic antigen (CEA) for malignant pleural effusion (MPE). Methods: The concentration of CEA in serum and pleural fluid of 286 patients with the diagnosis confirmed by pleural biopsy through medical thoracoscopy were retrospectively analyzed. MPE was confirmed in 171 cases which were divided into two groups (adenocarcinoma group with 121cases and non-adenocarcinoma group with 50 cases) and benign pleural effusion in 115 cases. The optimal cutoff for MPE and MPE caused by adenocarcinoma were determined by using the ROC curve. Results: The concentration of serum CEA 12.27(3.80, 58.45) μg/L was significantly higher in MPE caused by adenocarcinoma than that of non-adenocarcinoma 1.91(1.08, 4.55) μg/L and benign effusion 1.32(0.86, 2.27) μg/L (both P value of serum and pleural fluid CEA for MPE was 3.10 and 5.83 μg/L, the sensitivity respectively was 67.3% and 74.3%, the specificity respectively was 87.8% and 98.3%, positive predictive value respectively was 89.2% and 98.5%, negative predictive value respectively was 64.3% and 72.0%. The cutoff value of serum and pleural fluid CEA for MPE caused by adenocarcinoma was 3.54 and 7.30 μg/L, the sensitivity respectively was 76.0% and 91.7%, the specificity respectively was 74.0% and 72.0%, positive predictive value respectively was 87.6% and 88.8%, negative predictive value respectively was 56.1% and 78.3%. Conclusions: The concentration of serum and pleural fluid CEA have diagnostic significance to MPE, especially MPE caused by adenocarcinoma. The diagnostic value of pleural fluid CEA is superior to serum CEA.

  19. Combination of long noncoding RNA MALAT1 and carcinoembryonic antigen for the diagnosis of malignant pleural effusion caused by lung cancer.

    Science.gov (United States)

    Wang, Wan-Wei; Zhou, Xi-Lei; Song, Ying-Jian; Yu, Chang-Hua; Zhu, Wei-Guo; Tong, Yu-Suo

    2018-01-01

    Long noncoding RNAs (lncRNAs) are present in body fluids, but their potential as tumor biomarkers has never been investigated in malignant pleural effusion (MPE) caused by lung cancer. The aim of this study was to assess the clinical significance of lncRNAs in pleural effusion, which could potentially serve as diagnostic and predictive markers for lung cancer-associated MPE (LC-MPE). RNAs from pleural effusion were extracted in 217 cases of LC-MPE and 132 cases of benign pleural effusion (BPE). Thirty-one lung cancer-associated lncRNAs were measured using quantitative real-time polymerase chain reaction (qRT-PCR). The level of carcinoembryonic antigen (CEA) was also determined. The receiver operating characteristic (ROC) curves and the area under the ROC curve (AUC) were established to evaluate the sensitivity and specificity of the identified lncRNAs and other biomarkers. The correlations between baseline pleural effusion lncRNAs expression and response to chemotherapy were also analyzed. Three lncRNAs ( MALAT1 , H19 , and CUDR ) were found to have potential as diagnostic markers in LC-MPE. The AUCs for MALAT1 , H19 , CUDR , and CEA were 0.891, 0.783, 0.824, and 0.826, respectively. Using a logistic model, the combination of MALAT1 and CEA (AUC, 0.924) provided higher sensitivity and accuracy in predicting LC-MPE than CEA (AUC, 0.826) alone. Moreover, baseline MALAT1 expression in pleural fluid was inversely correlated with chemotherapy response in patients with LC-MPE. Pleural effusion lncRNAs were effective in differentiating LC-MPE from BPE. The combination of MALAT1 and CEA was more effective for LC-MPE diagnosis.

  20. Identification of the chlE gene encoding oxygen-independent Mg-protoporphyrin IX monomethyl ester cyclase in cyanobacteria.

    Science.gov (United States)

    Yamanashi, Kaori; Minamizaki, Kei; Fujita, Yuichi

    2015-08-07

    The fifth ring (E-ring) of chlorophyll (Chl) a is produced by Mg-protoporphyrin IX monomethyl ester (MPE) cyclase. There are two evolutionarily unrelated MPE cyclases: oxygen-independent (BchE) and oxygen-dependent (ChlA/AcsF) MPE cyclases. Although ChlA is the sole MPE cyclase in Synechocystis PCC 6803, it is yet unclear whether BchE exists in cyanobacteria. A BLAST search suggests that only few cyanobacteria possess bchE. Here, we report that two bchE candidate genes from Cyanothece strains PCC 7425 and PCC 7822 restore the photosynthetic growth and bacteriochlorophyll production in a bchE-lacking mutant of Rhodobacter capsulatus. We termed these cyanobacterial bchE orthologs "chlE." Copyright © 2015 Elsevier Inc. All rights reserved.

  1. Damage Threshold of In Vivo Rabbit Cornea by 2 micron Laser Irradiation

    National Research Council Canada - National Science Library

    Chen, Bo; Oliver, Jeffery; Dutta, Soumak; Rylander, III, Grady H; Thomsen, Sharon L; Welch, Ashley J

    2007-01-01

    To support refinement of the Maximum Permissible Exposure (MPE) safety limits, a series of experiments were conducted in vivo on Dutch Belted rabbit corneas to determine corneal minimum visible lesion thresholds...

  2. Mucuna pruriens (Velvet bean) rescues motor, olfactory, mitochondrial and synaptic impairment in PINK1B9 Drosophila melanogaster genetic model of Parkinson's disease.

    Science.gov (United States)

    Poddighe, Simone; De Rose, Francescaelena; Marotta, Roberto; Ruffilli, Roberta; Fanti, Maura; Secci, Pietro Paolo; Mostallino, Maria Cristina; Setzu, Maria Dolores; Zuncheddu, Maria Antonietta; Collu, Ignazio; Solla, Paolo; Marrosu, Francesco; Kasture, Sanjay; Acquas, Elio; Liscia, Anna

    2014-01-01

    The fruit fly Drosophila melanogaster (Dm) mutant for PTEN-induced putative kinase 1 (PINK1B9) gene is a powerful tool to investigate physiopathology of Parkinson's disease (PD). Using PINK1B9 mutant Dm we sought to explore the effects of Mucuna pruriens methanolic extract (Mpe), a L-Dopa-containing herbal remedy of PD. The effects of Mpe on PINK1B9 mutants, supplied with standard diet to larvae and adults, were assayed on 3-6 (I), 10-15 (II) and 20-25 (III) days old flies. Mpe 0.1% significantly extended lifespan of PINK1B9 and fully rescued olfactory response to 1-hexanol and improved climbing behavior of PINK1B9 of all ages; in contrast, L-Dopa (0.01%, percentage at which it is present in Mpe 0.1%) ameliorated climbing of only PINK1B9 flies of age step II. Transmission electron microscopy analysis of antennal lobes and thoracic ganglia of PINK1B9 revealed that Mpe restored to wild type (WT) levels both T-bars and damaged mitochondria. Western blot analysis of whole brain showed that Mpe, but not L-Dopa on its own, restored bruchpilot (BRP) and tyrosine hydroxylase (TH) expression to age-matched WT control levels. These results highlight multiple sites of action of Mpe, suggesting that its effects cannot only depend upon its L-Dopa content and support the clinical observation of Mpe as an effective medication with intrinsic ability of delaying the onset of chronic L-Dopa-induced long-term motor complications. Overall, this study strengthens the relevance of using PINK1B9 Dm as a translational model to study the properties of Mucuna pruriens for PD treatment.

  3. Mucuna pruriens (Velvet bean) Rescues Motor, Olfactory, Mitochondrial and Synaptic Impairment in PINK1B9 Drosophila melanogaster Genetic Model of Parkinson’s Disease

    Science.gov (United States)

    Ruffilli, Roberta; Fanti, Maura; Secci, Pietro Paolo; Mostallino, Maria Cristina; Setzu, Maria Dolores; Zuncheddu, Maria Antonietta; Collu, Ignazio; Solla, Paolo; Marrosu, Francesco; Kasture, Sanjay; Acquas, Elio; Liscia, Anna

    2014-01-01

    The fruit fly Drosophila melanogaster (Dm) mutant for PTEN-induced putative kinase 1 (PINK1B9) gene is a powerful tool to investigate physiopathology of Parkinson's disease (PD). Using PINK1B9 mutant Dm we sought to explore the effects of Mucuna pruriens methanolic extract (Mpe), a L-Dopa-containing herbal remedy of PD. The effects of Mpe on PINK1B9 mutants, supplied with standard diet to larvae and adults, were assayed on 3–6 (I), 10–15 (II) and 20–25 (III) days old flies. Mpe 0.1% significantly extended lifespan of PINK1B9 and fully rescued olfactory response to 1-hexanol and improved climbing behavior of PINK1B9 of all ages; in contrast, L-Dopa (0.01%, percentage at which it is present in Mpe 0.1%) ameliorated climbing of only PINK1B9 flies of age step II. Transmission electron microscopy analysis of antennal lobes and thoracic ganglia of PINK1B9 revealed that Mpe restored to wild type (WT) levels both T-bars and damaged mitochondria. Western blot analysis of whole brain showed that Mpe, but not L-Dopa on its own, restored bruchpilot (BRP) and tyrosine hydroxylase (TH) expression to age-matched WT control levels. These results highlight multiple sites of action of Mpe, suggesting that its effects cannot only depend upon its L-Dopa content and support the clinical observation of Mpe as an effective medication with intrinsic ability of delaying the onset of chronic L-Dopa-induced long-term motor complications. Overall, this study strengthens the relevance of using PINK1B9 Dm as a translational model to study the properties of Mucuna pruriens for PD treatment. PMID:25340511

  4. Mucuna pruriens (Velvet bean rescues motor, olfactory, mitochondrial and synaptic impairment in PINK1B9 Drosophila melanogaster genetic model of Parkinson's disease.

    Directory of Open Access Journals (Sweden)

    Simone Poddighe

    Full Text Available The fruit fly Drosophila melanogaster (Dm mutant for PTEN-induced putative kinase 1 (PINK1B9 gene is a powerful tool to investigate physiopathology of Parkinson's disease (PD. Using PINK1B9 mutant Dm we sought to explore the effects of Mucuna pruriens methanolic extract (Mpe, a L-Dopa-containing herbal remedy of PD. The effects of Mpe on PINK1B9 mutants, supplied with standard diet to larvae and adults, were assayed on 3-6 (I, 10-15 (II and 20-25 (III days old flies. Mpe 0.1% significantly extended lifespan of PINK1B9 and fully rescued olfactory response to 1-hexanol and improved climbing behavior of PINK1B9 of all ages; in contrast, L-Dopa (0.01%, percentage at which it is present in Mpe 0.1% ameliorated climbing of only PINK1B9 flies of age step II. Transmission electron microscopy analysis of antennal lobes and thoracic ganglia of PINK1B9 revealed that Mpe restored to wild type (WT levels both T-bars and damaged mitochondria. Western blot analysis of whole brain showed that Mpe, but not L-Dopa on its own, restored bruchpilot (BRP and tyrosine hydroxylase (TH expression to age-matched WT control levels. These results highlight multiple sites of action of Mpe, suggesting that its effects cannot only depend upon its L-Dopa content and support the clinical observation of Mpe as an effective medication with intrinsic ability of delaying the onset of chronic L-Dopa-induced long-term motor complications. Overall, this study strengthens the relevance of using PINK1B9 Dm as a translational model to study the properties of Mucuna pruriens for PD treatment.

  5. Single center experience on talc poudrage morbidity: focus on high talc dosage

    Directory of Open Access Journals (Sweden)

    Congedo Maria

    2011-06-01

    Full Text Available Abstract Malignant pleural effusion (MPE is a common clinical problem of concern for most of the pneumologists and thoracic surgeons. A general consensus regarding the use of talc poudrage in treatment of MPE exists, but only few studies analyzed in detail talc insufflation related pulmonary morbidity. In particular, ARDS talc-related is caused by physical and chemical effects of the small talc particles (50% particle size

  6. Mast cells mediate malignant pleural effusion formation.

    Science.gov (United States)

    Giannou, Anastasios D; Marazioti, Antonia; Spella, Magda; Kanellakis, Nikolaos I; Apostolopoulou, Hara; Psallidas, Ioannis; Prijovich, Zeljko M; Vreka, Malamati; Zazara, Dimitra E; Lilis, Ioannis; Papaleonidopoulos, Vassilios; Kairi, Chrysoula A; Patmanidi, Alexandra L; Giopanou, Ioanna; Spiropoulou, Nikolitsa; Harokopos, Vaggelis; Aidinis, Vassilis; Spyratos, Dionisios; Teliousi, Stamatia; Papadaki, Helen; Taraviras, Stavros; Snyder, Linda A; Eickelberg, Oliver; Kardamakis, Dimitrios; Iwakura, Yoichiro; Feyerabend, Thorsten B; Rodewald, Hans-Reimer; Kalomenidis, Ioannis; Blackwell, Timothy S; Agalioti, Theodora; Stathopoulos, Georgios T

    2015-06-01

    Mast cells (MCs) have been identified in various tumors; however, the role of these cells in tumorigenesis remains controversial. Here, we quantified MCs in human and murine malignant pleural effusions (MPEs) and evaluated the fate and function of these cells in MPE development. Evaluation of murine MPE-competent lung and colon adenocarcinomas revealed that these tumors actively attract and subsequently degranulate MCs in the pleural space by elaborating CCL2 and osteopontin. MCs were required for effusion development, as MPEs did not form in mice lacking MCs, and pleural infusion of MCs with MPE-incompetent cells promoted MPE formation. Once homed to the pleural space, MCs released tryptase AB1 and IL-1β, which in turn induced pleural vasculature leakiness and triggered NF-κB activation in pleural tumor cells, thereby fostering pleural fluid accumulation and tumor growth. Evaluation of human effusions revealed that MCs are elevated in MPEs compared with benign effusions. Moreover, MC abundance correlated with MPE formation in a human cancer cell-induced effusion model. Treatment of mice with the c-KIT inhibitor imatinib mesylate limited effusion precipitation by mouse and human adenocarcinoma cells. Together, the results of this study indicate that MCs are required for MPE formation and suggest that MC-dependent effusion formation is therapeutically addressable.

  7. Extração e pré-concentração de compostos orgânicos voláteis por permeação em membrana para análise cromatográfica Extraction and pre-concentration of volatile organic compounds by membrane permeation for chromatography analysis

    Directory of Open Access Journals (Sweden)

    Eduardo Carasek da Rocha

    2000-02-01

    Full Text Available This work discusses sample preparation processes for gas chromatography (GC based on the technique of extraction through membrane permeation (MPE. The MPE technique may be easily coupled to GC via a relatively simple device, which is a module that holds the membrane and is directly connected to the GC column. The possibility of operational errors due to sample handling is substantially reduced in an MPE-GC system because the sample preparation and the chemical analysis are accomplished as a one-step process. The MPE technique is of relatively wide application as it can be used for aqueous samples, solid samples and gaseous samples. Depending on the type of sample the extraction is performed with the membrane in direct contact with the sample or in contact with its headspace. The MPE-GC technique is very useful in trace analysis, due to the time-dependent enrichment of the analyte. A typical application of MPE-GC is the analysis of VOCs present in water that may be accomplished with detection limits at the low ppb (mugL-1 level.

  8. Cytokeratin positivity in myxopapillary ependymoma – a potential diagnostic pitfall

    Directory of Open Access Journals (Sweden)

    Sur Monalisa

    2008-10-01

    Full Text Available Abstract Background Myxopapillary ependymomas (MPE occur in the filum terminale of the spinal cord, but also present in extra-spinal locations such as subcutaneous tissue and brain. They are slow growing grade I gliomas. Areas of solid growth pattern with aggregates of cells with "epithelioid morphology" seen in MPE can mimic metastatic carcinoma. The presence of occasional cells with clear cytoplasm and morphology can resemble Chordoma. Diagnosis can be missed due to these morphological similarities, which could affect patient management and hence, long term survival. Case presentation We describe two cases of MPE with cytokeratin (AE1 AE3, CAM 5.2, Cytokeratin 7 and cytokeratin 20 expression. Conclusion MPE can be positive for Cytokeratins (CAM 5.2, AE1 AE3, CK7 and focally for EMA, which could be misdiagnosed as metastatic carcinoma. In cases demonstrating epithelioid and clear cell morphology, the diagnosis of MPE should be made in conjunction with histology, proper immunohistochemical profile which includes co-expression of GFAP, S-100 protein and epithelial markers, radiologic findings and site. It is important to be aware of the cytokeratin profile in MPE to avoid erroneous diagnosis with other tumour entities.

  9. Effect of Mucuna pruriens Seed Extract Pretreatment on the Responses of Spontaneously Beating Rat Atria and Aortic Ring to Naja sputatrix (Javan Spitting Cobra) Venom

    Science.gov (United States)

    Fung, Shin Yee; Tan, Nget Hong; Sim, Si Mui; Aguiyi, John C.

    2012-01-01

    Mucuna pruriens Linn. (velvet bean) has been used by native Nigerians as a prophylactic for snakebite. Rats pretreated with M. pruriens seed extract (MPE) have been shown to protect against the lethal and cardiovascular depressant effects of Naja sputatrix (Javan spitting cobra) venoms, and the protective effect involved immunological neutralization of the venom toxins. To investigate further the mechanism of the protective effect of MPE pretreatment against cobra venom toxicity, the actions of Naja sputatrix venom on spontaneously beating rat atria and aortic rings isolated from both MPE pretreated and untreated rats were studied. Our results showed that the MPE pretreatment conferred protection against cobra venom-induced depression of atrial contractility and atrial rate in the isolated atrial preparations, but it had no effect on the venom-induced contractile response of aortic ring preparation. These observations suggested that the protective effect of MPE pretreatment against cobra venom toxicity involves a direct protective action of MPE on the heart function, in addition to the known immunological neutralization mechanism, and that the protective effect does not involve action on blood vessel contraction. The results also suggest that M. pruriens seed may contain novel cardioprotective agent with potential therapeutic value. PMID:21785646

  10. The protective effect of Mucuna pruriens seeds against snake venom poisoning.

    Science.gov (United States)

    Tan, Nget Hong; Fung, Shin Yee; Sim, Si Mui; Marinello, Enrico; Guerranti, Roberto; Aguiyi, John C

    2009-06-22

    The seed, leaf and root of Mucuna pruriens have been used in traditional medicine for treatments of various diseases. In Nigeria, the seed is used as oral prophylactics for snakebite. To study the protective effects of Mucuna pruriens seed extract against the lethalities of various snake venoms. Rats were pre-treated with Mucuna pruriens seed extract and challenged with various snake venoms. The effectiveness of anti-Mucuna pruriens (anti-MPE) antibody to neutralize the lethalities of snake venoms was investigated by in vitro neutralization. In rats, MPE pre-treatment conferred effective protection against lethality of Naja sputatrix venom and moderate protection against Calloselasma rhodostoma venom. Indirect ELISA and immunoblotting studies showed that there were extensive cross-reactions between anti-MPE IgG and venoms from many different genera of poisonous snakes, suggesting the involvement of immunological neutralization in the protective effect of MPE pre-treatment against snake venom poisoning. In vitro neutralization experiments showed that the anti-MPE antibodies effectively neutralized the lethalities of Asiatic cobra (Naja) venoms, but were not very effective against other venoms tested. The anti-MPE antibodies could be used in the antiserum therapy of Asiatic cobra (Naja) bites.

  11. Differential effects of phytotherapic preparations in the hSOD1 Drosophila melanogaster model of ALS

    Science.gov (United States)

    De Rose, Francescaelena; Marotta, Roberto; Talani, Giuseppe; Catelani, Tiziano; Solari, Paolo; Poddighe, Simone; Borghero, Giuseppe; Marrosu, Francesco; Sanna, Enrico; Kasture, Sanjay; Acquas, Elio; Liscia, Anna

    2017-01-01

    The present study was aimed at characterizing the effects of Withania somnifera (Wse) and Mucuna pruriens (Mpe) on a Drosophila melanogaster model for Amyotrophic Lateral Sclerosis (ALS). In particular, the effects of Wse and Mpe were assessed following feeding the flies selectively overexpressing the wild human copper, zinc-superoxide dismutase (hSOD1-gain-of-function) in Drosophila motoneurons. Although ALS-hSOD1 mutants showed no impairment in life span, with respect to GAL4 controls, the results revealed impairment of climbing behaviour, muscle electrophysiological parameters (latency and amplitude of ePSPs) as well as thoracic ganglia mitochondrial functions. Interestingly, Wse treatment significantly increased lifespan of hSDO1 while Mpe had not effect. Conversely, both Wse and Mpe significantly rescued climbing impairment, and also latency and amplitude of ePSPs as well as failure responses to high frequency DLM stimulation. Finally, mitochondrial alterations were any more present in Wse- but not in Mpe-treated hSOD1 mutants. Hence, given the role of inflammation in the development of ALS, the high translational impact of the model, the known anti-inflammatory properties of these extracts, and the viability of their clinical use, these results suggest that the application of Wse and Mpe might represent a valuable pharmacological strategy to counteract the progression of ALS and related symptoms. PMID:28102336

  12. Effect of Mucuna pruriens Seed Extract Pretreatment on the Responses of Spontaneously Beating Rat Atria and Aortic Ring to Naja sputatrix (Javan Spitting Cobra Venom

    Directory of Open Access Journals (Sweden)

    Shin Yee Fung

    2012-01-01

    Full Text Available Mucuna pruriens Linn. (velvet bean has been used by native Nigerians as a prophylactic for snakebite. Rats pretreated with M. pruriens seed extract (MPE have been shown to protect against the lethal and cardiovascular depressant effects of Naja sputatrix (Javan spitting cobra venoms, and the protective effect involved immunological neutralization of the venom toxins. To investigate further the mechanism of the protective effect of MPE pretreatment against cobra venom toxicity, the actions of Naja sputatrix venom on spontaneously beating rat atria and aortic rings isolated from both MPE pretreated and untreated rats were studied. Our results showed that the MPE pretreatment conferred protection against cobra venom-induced depression of atrial contractility and atrial rate in the isolated atrial preparations, but it had no effect on the venom-induced contractile response of aortic ring preparation. These observations suggested that the protective effect of MPE pretreatment against cobra venom toxicity involves a direct protective action of MPE on the heart function, in addition to the known immunological neutralization mechanism, and that the protective effect does not involve action on blood vessel contraction. The results also suggest that M. pruriens seed may contain novel cardioprotective agent with potential therapeutic value.

  13. 3-MCPD 1-Palmitate Induced Tubular Cell Apoptosis In Vivo via JNK/p53 Pathways

    Science.gov (United States)

    Liu, Man; Huang, Guoren; Wang, Thomas T.Y.; Sun, Xiangjun; Yu, Liangli (Lucy)

    2016-01-01

    Fatty acid esters of 3-chloro-1, 2-propanediol (3-MCPD esters) are a group of processing induced food contaminants with nephrotoxicity but the molecular mechanism(s) remains unclear. This study investigated whether and how the JNK/p53 pathway may play a role in the nephrotoxic effect of 3-MCPD esters using 3-MCPD 1-palmitate (MPE) as a probe compound in Sprague Dawley rats. Microarray analysis of the kidney from the Sprague Dawley rats treated with MPE, using Gene Ontology categories and KEGG pathways, revealed that MPE altered mRNA expressions of the genes involved in the mitogen-activated protein kinase (JNK and ERK), p53, and apoptotic signal transduction pathways. The changes in the mRNA expressions were confirmed by qRT-PCR and Western blot analyses and were consistent with the induction of tubular cell apoptosis as determined by histopathological, TUNEL, and immunohistochemistry analyses in the kidneys of the Sprague Dawley rats. Additionally, p53 knockout attenuated the apoptosis, and the apoptosis-related protein bax expression and cleaved caspase-3 activation induced by MPE in the p53 knockout C57BL/6 mice, whereas JNK inhibitor SP600125 but not ERK inhibitor U0126 inhibited MPE-induced apoptosis, supporting the conclusion that JNK/p53 might play a critical role in the tubular cell apoptosis induced by MPE and other 3-MCPD fatty acid esters. PMID:27008853

  14. Void fraction correlations analysis and their influence on heat transfer of helical double-pipe vertical evaporator

    International Nuclear Information System (INIS)

    Parrales, Arianna; Colorado, Dario; Huicochea, Armando; Díaz, Juan; Alfredo Hernández, J.

    2014-01-01

    Highlights: • 50 void fraction correlations were evaluated on heat transfer in vertical evaporators. • Two-phase flow model based on control volume formulation was used. • The drift flux parameter is common in all correlations with satisfactory results. - Abstract: An analysis of 50 void fraction correlations available in the literature was performed to describe two-phase flow mechanism inside two helical double-pipe vertical evaporators. The evaporators considered water as working fluid connected in countercurrent so the change of phase was carried out into the internal tube. The discretized equations of continuity, momentum and energy in each flow were coupled using an implicit step by step method. The selection of the void fraction correlations for the mathematical model was based on inclusion of some theoretical limits. The results of this analysis were compared with the experimental data in steady state for two different evaporators, obtaining good agreement in the evaporation process for only 7 void fraction correlations. The Armand and Massena correlation had a mean percentage error (MPE) of 3.08%, followed by Rouhanni and Axelsson I adquired MPE=3.16%, Chisholm and Armand obtained MPE=3.18%, Steiner as well as Rouhanni and Axelsson II with MPE=3.19%, Bestion reached MPE=3.20% and Flanigan presented MPE=3.21%. Furthermore, the experimental and simulated heat flux were acceptable (R 2 =0.939). Finally, the results showed that the drift flux parameter was important to evaluate the void fraction

  15. Prognostic Significance of Blood, Serum, and Ascites Parameters in Patients with Malignant Peritoneal Mesothelioma or Peritoneal Carcinomatosis.

    Science.gov (United States)

    Su, Shan-Shan; Zheng, Guo-Qi; Yin, Wen-Jie; Liang, Yu-Fei; Liu, Ying-Ying; Song, Hui; Sun, Ning-Ning; Yang, Yu-Xin

    2018-01-01

    To determine effects of the biochemical and cytological properties of blood, serum, and ascites on survival of patients with malignant peritoneal effusion (MPeE), including malignant peritoneal mesothelioma (MPeM) and peritoneal carcinomatosis (PC), we conducted a retrospective study of patients with MPeE and healthy controls. Potential prognostic factors were identified as follows: age, sex, blood neutrophil-to-lymphocyte ratio (NLR), serum parameters, ascites parameters, serum-ascites albumin gradient, and the ascites-serum LDH ratio. Compared to those of the control group, serum albumin levels were significantly lower, and the NLR and serum LDH levels were significantly higher in the MPeE group. Overall survival (OS) was longer in patients with MPeM compared to that in patients with PC. Compared with patients in the MPeM, patients with PC had higher NLRs, ascites glucose levels, serum-ascites albumin gradients, and serum LDH levels. In contrast, their ascites albumin levels and ascites-serum LDH ratios were lower. Univariate analyses indicated that the NLR, serum LDH levels, ascites LDH levels, ascites coenocyte levels, and the ascites coenocyte-to-monocyte ratios affected the OS. Multivariate analyses identified only serum and ascites LDH levels as independent prognostic factors.

  16. Diagnosis and management options in malignant pleural effusions

    Science.gov (United States)

    Dixit, Ramakant; Agarwal, KC; Gokhroo, Archana; Patil, Chetan B; Meena, Manoj; Shah, Narender S; Arora, Piyush

    2017-01-01

    Malignant pleural effusion (MPE) denotes an advanced malignant disease process. Most of the MPE are metastatic involvement of the pleura from primary malignancy at lung, breast, and other body sites apart from lymphomas. The diagnosis of MPE has been traditionally made on cytological examination of pleural fluid and/or histological examination of pleural biopsy tissue that still remains the initial approach in these cases. There has been tremendous advancement in the diagnosis of MPE now a day with techniques i.e. characteristic Ultrasound and computed tomography features, image guided biopsies, fluorodeoxyglucose-positron emission tomography imaging, thoracoscopy with direct biopsy under vision, tumor marker studies and immunocytochemical analysis etc., that have made possible an early diagnosis of MPE. The management of MPE still remains a challenge to pulmonologist and oncologist. Despite having various modalities with better tolerance such as pleurodesis and indwelling pleural catheters etc., for long-term control, all the management approaches remain palliative to improve the quality of life and reduce symptoms. While choosing an appropriate management intervention, one should consider the clinical status of the patient, life expectancy, overall cost, availability and comparative institutional outcomes, etc. PMID:28360465

  17. Switching off malignant pleural effusion formation—fantasy or future?

    Science.gov (United States)

    Giannou, Anastasios D.; Stathopoulos, Georgios T.

    2015-01-01

    Malignant pleural effusion (MPE) is common and difficult to treat. In the vast majority of patients the presence of MPE heralds incurable disease, associated with poor quality of life, morbidity and mortality. Current therapeutic approaches are inefficient and merely offer palliation of associated symptoms. Recent scientific progress has shed light in the biologic processes governing the mechanisms behind the pathobiology of MPE. Pleural based tumors interfere with pleural fluid drainage, as well as the host vasculature and immune system, resulting in decreased fluid absorption and increased pleural fluid production via enhanced plasma extravasation into the pleural space. In order to achieve this feat, pleural based tumors must elicit critical vasoactive events in the pleura, thus forming a favorable microenvironment for tumor dissemination and MPE development. Such properties involve specific transcriptional signaling cascades in addition to secretion of important mediators which attract and activate host cell populations which, in turn, impact tumor cell functions. The dissection of the biologic steps leading to MPE formation provides novel therapeutic targets and recent research findings provide encouraging results towards future therapeutic innovations in MPE management. PMID:26150914

  18. Diagnosis and management options in malignant pleural effusions

    Directory of Open Access Journals (Sweden)

    Ramakant Dixit

    2017-01-01

    Full Text Available Malignant pleural effusion (MPE denotes an advanced malignant disease process. Most of the MPE are metastatic involvement of the pleura from primary malignancy at lung, breast, and other body sites apart from lymphomas. The diagnosis of MPE has been traditionally made on cytological examination of pleural fluid and/or histological examination of pleural biopsy tissue that still remains the initial approach in these cases. There has been tremendous advancement in the diagnosis of MPE now a day with techniques i.e. characteristic Ultrasound and computed tomography features, image guided biopsies, fluorodeoxyglucose-positron emission tomography imaging, thoracoscopy with direct biopsy under vision, tumor marker studies and immunocytochemical analysis etc., that have made possible an early diagnosis of MPE. The management of MPE still remains a challenge to pulmonologist and oncologist. Despite having various modalities with better tolerance such as pleurodesis and indwelling pleural catheters etc., for long-term control, all the management approaches remain palliative to improve the quality of life and reduce symptoms. While choosing an appropriate management intervention, one should consider the clinical status of the patient, life expectancy, overall cost, availability and comparative institutional outcomes, etc.

  19. Vascular endothelial growth factor and protein level in pleural effusion for differentiating malignant from benign pleural effusion.

    Science.gov (United States)

    Wu, Da-Wei; Chang, Wei-An; Liu, Kuan-Ting; Yen, Meng-Chi; Kuo, Po-Lin

    2017-09-01

    Pleural effusion is associated with multiple benign and malignant conditions. Currently no biomarkers differentiate malignant pleural effusion (MPE) and benign pleural effusion (BPE) sensitively and specifically. The present study identified a novel combination of biomarkers in pleural effusion for differentiating MPE from BPE by enrolling 75 patients, 34 with BPE and 41 with MPE. The levels of lactate dehydrogenase, glucose, protein, and total cell, neutrophil, monocyte and lymphocyte counts in the pleural effusion were measured. The concentrations of interleukin (IL)-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, tumor necrosis factor-α, interferon γ, transforming growth factor-β1, colony stimulating factor 2, monocyte chemoattractant protein-1 and vascular endothelial growth factor (VEGF) were detected using cytometric bead arrays. Protein and VEGF levels differed significantly between patients with BPE and those with MPE. The optimal cutoff value of VEGF and protein was 214 pg/ml and 3.35 g/dl respectively, according to the receiver operating characteristic curve. A combination of VEGF >214 pg/ml and protein >3.35 g/dl in pleural effusion presented a sensitivity of 92.6% and an accuracy of 78.6% for MPE, but was not associated with a decreased survival rate. These results suggested that this novel combination strategy may provide useful biomarkers for predicting MPE and facilitating early diagnosis.

  20. A water extract of Mucuna pruriens provides long-term amelioration of parkinsonism with reduced risk for dyskinesias.

    Science.gov (United States)

    Lieu, Christopher A; Kunselman, Allen R; Manyam, Bala V; Venkiteswaran, Kala; Subramanian, Thyagarajan

    2010-08-01

    Dopaminergic anti-parkinsonian medications, such as levodopa (LD) cause drug-induced dyskinesias (DID) in majority of patients with Parkinson's disease (PD). Mucuna pruriens, a legume extensively used in Ayurveda to treat PD, is reputed to provide anti-parkinsonian benefits without inducing DID. We compared the behavioral effects of chronic parenteral administration of a water extract of M. pruriens seed powder (MPE) alone without any additives, MPE combined with the peripheral dopa-decarboxylase inhibitor (DDCI) benserazide (MPE+BZ), LD+BZ and LD alone without BZ in the hemiparkinsonian rat model of PD. A battery of behavioral tests assessed by blinded investigators served as outcome measures in these randomized trials. In experiment 1, animals that received LD+BZ or MPE+BZ at high (6mg/kg) and medium (4mg/kg) equivalent doses demonstrated significant alleviation of parkinsonism, but, developed severe dose-dependent DID. LD+BZ at low doses (2mg/kg) did not provide significant alleviation of parkinsonism. In contrast, MPE+BZ at an equivalent low dose significantly ameliorated parkinsonism. In experiment 2, MPE without any additives (12mg/kg and 20mg/kg LD equivalent dose) alleviated parkinsonism with significantly less DID compared to LD+BZ or MPE+BZ. In experiment 3, MPE without additives administered chronically provided long-term anti-parkinsonian benefits without causing DID. In experiment 4, MPE alone provided significantly more behavioral benefit when compared to the equivalent dose of synthetic LD alone without BZ. In experiment 5, MPE alone reduced the severity of DID in animals initially primed with LD+BZ. These findings suggest that M. pruriens contains water-soluble ingredients that either have an intrinsic DDCI-like activity or mitigate the need for an add-on DDCI to ameliorate parkinsonism. These unique long-term anti-parkinsonian effects of a parenterally administered water extract of M. pruriens seed powder may provide a platform for future drug

  1. Pleural fluid cell-free DNA integrity index to identify cytologically negative malignant pleural effusions including mesotheliomas

    International Nuclear Information System (INIS)

    Sriram, Krishna B; Courtney, Deborah; Yang, Ian A; Bowman, Rayleen V; Fong, Kwun M; Relan, Vandana; Clarke, Belinda E; Duhig, Edwina E; Windsor, Morgan N; Matar, Kevin S; Naidoo, Rishendran; Passmore, Linda; McCaul, Elizabeth

    2012-01-01

    The diagnosis of malignant pleural effusions (MPE) is often clinically challenging, especially if the cytology is negative for malignancy. DNA integrity index has been reported to be a marker of malignancy. The aim of this study was to evaluate the utility of pleural fluid DNA integrity index in the diagnosis of MPE. We studied 75 pleural fluid and matched serum samples from consecutive subjects. Pleural fluid and serum ALU DNA repeats [115bp, 247bp and 247bp/115bp ratio (DNA integrity index)] were assessed by real-time quantitative PCR. Pleural fluid and serum mesothelin levels were quantified using ELISA. Based on clinico-pathological evaluation, 52 subjects had MPE (including 16 mesotheliomas) and 23 had benign effusions. Pleural fluid DNA integrity index was higher in MPE compared with benign effusions (1.2 vs. 0.8; p<0.001). Cytology had a sensitivity of 55% in diagnosing MPE. If cytology and pleural fluid DNA integrity index were considered together, they exhibited 81% sensitivity and 87% specificity in distinguishing benign and malignant effusions. In cytology-negative pleural effusions (35 MPE and 28 benign effusions), elevated pleural fluid DNA integrity index had an 81% positive predictive value in detecting MPEs. In the detection of mesothelioma, at a specificity of 90%, pleural fluid DNA integrity index had similar sensitivity to pleural fluid and serum mesothelin (75% each respectively). Pleural fluid DNA integrity index is a promising diagnostic biomarker for identification of MPEs, including mesothelioma. This biomarker may be particularly useful in cases of MPE where pleural aspirate cytology is negative, and could guide the decision to undertake more invasive definitive testing. A prospective validation study is being undertaken to validate our findings and test the clinical utility of this biomarker for altering clinical practice

  2. Improving Radar QPE's in Complex Terrain for Improved Flash Flood Monitoring and Prediction

    Science.gov (United States)

    Cifelli, R.; Streubel, D. P.; Reynolds, D.

    2010-12-01

    Quantitative Precipitation Estimation (QPE) is extremely challenging in regions of complex terrain due to a combination of issues related to sampling. In particular, radar beams are often blocked or scan above the liquid precipitation zone while rain gauge density is often too low to properly characterize the spatial distribution of precipitation. Due to poor radar coverage, rain gauge networks are used by the National Weather Service (NWS) River Forecast Centers as the principal source for QPE across the western U.S. The California Nevada River Forecast Center (CNRFC) uses point rainfall measurements and historical rainfall runoff relationships to derive river stage forecasts. The point measurements are interpolated to a 4 km grid using Parameter-elevation Regressions on Independent Slopes Model (PRISM) data to develop a gridded 6-hour QPE product (hereafter referred to as RFC QPE). Local forecast offices can utilize the Multi-sensor Precipitation Estimator (MPE) software to improve local QPE’s and thus local flash flood monitoring and prediction. MPE uses radar and rain gauge data to develop a combined QPE product at 1-hour intervals. The rain gauge information is used to bias correct the radar precipitation estimates so that, in situations where the rain gauge density and radar coverage are adequate, MPE can take advantage of the spatial coverage of the radar and the “ground truth” of the rain gauges to provide an accurate QPE. The MPE 1-hour QPE analysis should provide better spatial and temporal resolution for short duration hydrologic events as compared to 6-hour analyses. These hourly QPEs are then used to correct radar derived rain rates used by the Flash Flood Monitoring and Prediction (FFMP) software in forecast offices for issuance of flash flood warnings. Although widely used by forecasters across the eastern U.S., MPE is not used extensively by the NWS in the west. Part of the reason for the lack of use of MPE across the west is that there has

  3. Pleural Effusion in Multiple Myeloma.

    Science.gov (United States)

    Wang, Zhuo; Xia, Guoguang; Lan, Ling; Liu, Fayong; Wang, Yanxun; Liu, Baoyue; Ding, Yi; Dai, Li; Zhang, Yunjian

    2016-01-01

    Pleural effusion is rarely observed in patients with multiple myeloma (MM). Myeloma cell infiltration or invasion to the pleura is very rare. This study aimed to investigate the clinical characteristics of pleural effusion in patients with MM. We retrospectively reviewed the medical records of patients diagnosed with pleural effusion, MM, and pleural effusion with MM between 2004 and 2014 at Beijing Jishuitan Hospital. The present study included patients with pleural effusion who underwent cytological, bacteriological, biochemical and other testing. The cytopathology of abnormal pleural effusion cells was not diagnostic, thus flow cytometry was performed. MM was defined using the diagnosis standard of NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) 2014 for MM. This study included 3,480 pleural effusion patients and 319 MM patients. There were 34 patients with both MM and pleural effusion (17 men and 17 women). The average age was 63 years (range, 48-84 years). Pleural effusion with MM was caused by congestive heart disease, chronic renal failure, hypoalbuminemia, pulmonary infarctions, cirrhosis, pulmonary arterial hypertension, parapneumonic effusion, tuberculous pleural effusion, and myelomatous pleural effusion (MPE). The diagnosis of MPE was confirmed by the detection of myeloma cells in the pleural fluid using flow cytometric analyses. There were only 2 MPE cases in our study. The first MPE case was a woman. The first clinical manifestation was pleural effusion, and the diagnosis was non-secretory MM, DSS stage IIIA (Durie-Salmon staging system); ISS stage I (the International Staging System). The second MPE case was a man who was diagnosed with MM IgA-κ, DSS stage IIIA; ISS stage II. The detection rate of MPE was very low. MPE tended to present with yellow exudates and the lack of physical and chemical characteristics. Furthermore, patients with MPE exhibited many yellow nodules on the pleura. These nodules were lobulated and had abundant

  4. Enzyme-catalyzed hydrolysis of dentin adhesives containing a new urethane-based trimethacrylate monomer

    Science.gov (United States)

    Park, Jong-Gu; Ye, Qiang; Topp, Elizabeth M.; Spencer, Paulette

    2009-01-01

    A new trimethacrylate monomer with urethane-linked groups, 1,1,1-tri-[4-(methacryloxyethylamino-carbonyloxy)-phenyl]ethane (MPE), was synthesized, characterized, and used as a co-monomer in dentin adhesives. Dentin adhesives containing 2-hydroxyethyl methacrylate (HEMA, 45% w/w) and 2,2-bis[4(2-hydroxy-3-methacryloyloxy-propyloxy)-phenyl] propane (BisGMA, 30% w/w) in addition to MPE (25% w/w) were formulated with H2O at 0 (MPE0), 8 (MPE8) and 16 wt % water (MPE16) to simulate the wet demineralized dentin matrix and compared with controls [HEMA/BisGMA, 45/55 w/w, at 0 (C0), 8 (C8) and 16 wt% water (C16)]. The new adhesive showed a degree of double bond conversion and mechanical properties comparable with control, with good penetration into the dentin surface and a uniform adhesive/dentin interface. On exposure to porcine liver esterase, the net cumulative methacrylic acid (MAA) release from the new adhesives was dramatically (P < 0.05) decreased relative to the control, suggesting that the new monomer improves esterase resistance. PMID:19582843

  5. Prophylactic effect of Mucuna pruriens Linn (velvet bean) seed extract against experimental Naja sputatrix envenomation: gene expression studies.

    Science.gov (United States)

    Fung, Shin Yee; Sim, Si Mui; Kandiah; Jeyaseelan; Armugam, Arunmozhiarasi; Aguiyi, John Chinyere; Tan, Nget Hong

    2014-09-01

    Mucuna pruriens is widely used in traditional medicine for treatments of various diseases. In certain region of Nigeria, the seed is used as oral prophylactics for snakebite. Rats pretreated with the aqueous extract from M. pruriens seed (MPE) were protected against the lethal effects of Naja sputatrix (Javan spitting cobra) venom [Tan et al., J Ethnopharmacol, 123 (2009) 356]. The pretreatment also protected against venom-induced histopathological changes in rat heart. To contribute to the understanding of the mechanism of cardio-protective action, the present study examined the effects of MPE-pretreatment on gene expression profile of rat heart as well as effect of MPE-pretreatment on N. sputatrix venom-induced gene expression alterations in rat heart. The gene expression profiles were examined by microarray analysis and verified by real time PCR. The results showed that pretreatment with MPE caused 50 genes in the rat heart substantially up-regulated of which 19 were related to immune responses, 7 were related to energy production and metabolism. The up-regulation of genes related to energy metabolism probably plays a role in maintaining the viability of the heart. Four other genes that were up-regulated (alpha synuclein, natriuretic peptide precursor, calsequestrin and triadin) were involved in the maintenance of homeostasis of the heart or maintaining its viability, thereby contributing to the direct protective action. The results demonstrated that protective effect of MPE pretreatment against snake venom poisoning may involve a direct action on the heart.

  6. The efficacy of Jackson drain in the application to be a tunnel pleural catheter (TPC) in the management of malignant pleural effusion.

    Science.gov (United States)

    Tscheikuna, Jamsak; Thomrongpairoj, Preecha; Disayabutr, Suppareurg

    2011-06-01

    Malignant pleural effusion (MPE) is a common clinical problem in patients with advanced cancer and portends a poor prognosis, which means survival of less than six months. In June 1997, the US-FDA approved an indwelling TPC with a one-way drainage valve to be used in the management of MPE. Although popularity of this TPC has increased over the past few years, the experience with this device remains limited in Thai patients. One of the reasons is its high cost. Assess the efficacy and the safety of customary indwelling TPC by using Jackson drain in the management of patients with symptomatic MPE. Ten patients with symptomatic MPE were receiving these catheters (18 Fr Silicone catheters with 25 cm fenestrated length) to drain effusion via plastic vacuum bottles (250 ml) every other day or as needed to relieve dyspnea. The patient's dyspnic respiration, quality of life, and comfort during the catheter's application were quantified with a Borg score, the St. George Respiratory Disease Questionnaire (SGRQ), and the comfort's score, respectively. These parameters were recorded at initial (before insertion) and 2-week follow-up visit. Pain after 24 hours of each insertion was quantified by visual pain analogue scale (VPAS). Patients were followed until either death or catheter removal. The Borg score, SGRQ, and comfort's score showed significant improvement at 2-week visit (p drain was effective in the treatment of MPE as a TPC without early complications.

  7. Application of Fungicides and Microalgal Phenolic Extracts for the Direct Control of Fumonisin Contamination in Maize.

    Science.gov (United States)

    Scaglioni, Priscila Tessmer; Blandino, Massimo; Scarpino, Valentina; Giordano, Debora; Testa, Giulio; Badiale-Furlong, Eliana

    2018-05-16

    Fungicides and, for the first time, microalgal phenolic extracts (MPE) from Spirulina sp. and Nannochloropsis sp. were applied on maize culture media under field conditions to evaluate their ability to minimize Fusarium species development and fumonisin production. An in vitro assay against F. verticillioides was carried out using maize grains as the culture medium. An open-field experiment was carried out in Northwest Italy under natural infection conditions. The compared treatments were factorial combinations of two insecticide treatments (an untreated control and pyrethroid, used against European Corn Borer), four antifungal treatments (an untreated control, MPE from Spirulina sp., MPE from Nannochloropsis sp., and a synthetic fungicide), and two timings of the application of the antifungal compounds (at maize flowering and at the milk stage). The MPE compounds were capable of inhibiting fumonisin production in vitro more efficiently than tebuconazole. Insecticide application reduced the infection by Fusarium species and subsequent fumonisin contamination. However, fumonisins in maize fields were not significantly controlled by either fungicide or MPE application.

  8. Potential effect of Olea europea leaves, Sonchus oleraceus leaves and Mangifera indica peel extracts on aromatase activity in human placental microsomes and CYP19A1 expression in MCF-7 cell line: Comparative study.

    Science.gov (United States)

    Shaban, N Z; Hegazy, W A; Abdel-Rahman, S M; Awed, O M; Khalil, S A

    2016-08-29

    Aromatase inhibitors (AIs) provide novel approaches to the adjuvant therapy for postmenopausal women with estrogen-receptor-positive (ER+) breast cancers. In this study, different plant extracts from Olea europaea leaves (OLE), Sonchus oleraceus L. (SOE) and Mangifera indica peels (MPE) were prepared to identify phytoconstituents and measure antioxidant capacities. The effects of these three extracts on aromatase activity in human placental microsomes were evaluated. Additionally, the effects of these extracts on tissue-specific promoter expression of CYP19A1 gene in cell culture model (MCF-7) were assessed using qRT-PCR. Results showed a concentration-dependent decrease in aromatase activity after treatment with OLE and MPE, whereas, SOE showed a biphasic effect. The differential effects of OLE, SOE and MPE on aromatase expression showed that OLE seems to be the most potent suppressor followed by SOE and then MPE. These findings indicate that OLE has effective inhibitory action on aromatase at both the enzymatic and expression levels, in addition to its cytotoxic effect against MCF-7 cells. Also, MPE may be has the potential to be used as a tissue-specific aromatase inhibitor (selective aromatase inhibitor) and it may be promising to develop a new therapeutic agent against ER+ breast cancer.

  9. Diagnostic value of medical thoracoscopy in malignant pleural effusion induced by non-Hodgkin's lymphoma.

    Science.gov (United States)

    Wang, Zhen; Wu, Yan-Bing; Xu, Li-Li; Jin, Mu-Lan; Diao, Xiao-Li; Wang, Xiao-Juan; Tong, Zhao-Hui; Shi, Huan-Zhong

    2017-12-01

    Malignant pleural effusion (MPE) appears in up to 20% of patients with non-Hodgkin's lymphoma (NHL). The present study aimed to assess the efficacy of medical thoracoscopy (MT) in the diagnosis of patients with MPE induced by NHL. Between July 2005 and June 2014, 833 patients with pleural effusions of unknown etiology underwent MT in Beijing Chaoyang Hospital (Beijing, China), where diagnostic thoracocentesis or/and blind pleural biopsy had failed to yield an answer. Demographic, radiographic, thoracoscopic, histological and immunophenotyping data of 10 NHL patients with MPE were then retrospectively analyzed. Under medical thoracoscopy, pleural nodules (in n=6 patients), hyperemia (n=5), plaque-like lesions (n=4), pleural thickening (n=3), cellulose (n=3), ulcer (n=2), adhesion (n=2), and scattered hemorrhagic spots (n=1) were observed on the surface of parietal pleura. Histopathological and immunohistochemical analysis of pleural biopsy samples led to a correct diagnosis of B-cell NHL in 7 patients and T-lymphoblastic NHL in 2 patients. Data from the present study demonstrated that pleural biopsy through MT achieved a definite diagnosis of NHL in 9 out of 10 (90%) patients with MPE induced by NHL. Therefore, MT is a useful method for diagnosing MPE induced by NHL.

  10. The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra (Naja sputatrix) venom in rats.

    Science.gov (United States)

    Fung, S Y; Tan, N H; Liew, S H; Sim, S M; Aguiyi, J C

    2009-04-01

    Seed of Mucuna pruriens (Velvet beans) has been prescribed by traditional medicine practitioners in Nigeria as a prophylactic oral antisnake remedy. In the present studies, we investigated the protective effects of M. pruriens seed extract (MPE) against histopathological changes induced by intravenous injection of Naja sputatrix (Malayan cobra) venom in rats pretreated with the seed extract. Examination by light microscope revealed that the venom induced histopathological changes in heart and blood vessels in liver, but no effect on brain, lung, kidney and spleen. The induced changes were prevented by pretreatment of the rats with MPE. Our results suggest that MPE pretreatment protects rat heart and liver blood vessels against cobra venom-induced damages.

  11. Protective effects of Mucuna pruriens seed extract pretreatment against cardiovascular and respiratory depressant effects of Calloselasma rhodostoma (Malayan pit viper) venom in rats.

    Science.gov (United States)

    Fung, S Y; Tan, N H; Sim, S M

    2010-12-01

    The protective effects of Mucuna pruriens seed extract (MPE) against the cardio-respiratory depressant and neuromuscular paralytic effects induced by injection of Calloselasma rhodostoma (Malayan pit viper) venom in anaesthetized rats were investigated. While MPE pretreatment did not reverse the inhibitory effect of the venom on the gastrocnemius muscle excitability, it significantly attenuated the venom-induced cardio-respiratory depressant effects (p < 0.05). The protection effects may have an immunological mechanism, as indicated by the presence of several proteins in the venom that are immunoreactive against anti-MPE. However, we cannot rule out the possibility that the pretreatment may exert a direct, non-immunological protective action against the venom.

  12. El arrendamiento financiero y valuación de opciones reales

    Directory of Open Access Journals (Sweden)

    Gastón Silverio Milanesi

    2016-01-01

    Full Text Available El trabajo estudia diferentes opciones reales simples y compuestas contenidas en los contratos de leasing, bajo una metodología que combina el método de préstamo equivalente (MPE y opciones reales. Primero se presenta formalmente el MPE y el modelo binomial para valorar las opciones del contrato. Seguida- mente se analiza el valor al vencimiento de las opciones del leasing clasificadas en: a simple: de compra, de cancelar anticipadamente, de renovación y excluyente de renovación-compra, y b compuesta: a riesgo (venture ; canon atado a intensidad de uso (percentage y de pago diferido. Utilizando diferentes casos son valuadas las opciones combinando el modelo binomial y el MPE, estimando valor expandido y valor el valor de la opción sobre el valor. Finalmente se presentan las principales conclusiones.

  13. Synthesis and characterization of biosheet impregnated with Macrotyloma uniflorum extract for burn/wound dressings.

    Science.gov (United States)

    Muthukumar, Thangavelu; Senthil, Rethinam; Sastry, Thotapalli Parvathaleswara

    2013-02-01

    Developing biomaterials having wound healing properties within the search of a common man is the need of hour, particularly in developing and third world countries. Keeping this objective in view we have developed a wound dressing material, in sheet form, containing fish scale collagen (FSC) and physiologically clotted fibrin (PCF), both are by products of aqua food and meat industries respectively. To impart antimicrobial properties to the composite sheet, it was incorporated with Macrotyloma uniflorum plant extract (MPE). SEM pictures have shown that FSC:PCF:MPE composite has fibrous and porous surface which helps in transportation of oxygen as well as absorbing wound fluids and their evaporation. The biomaterials have shown 100% biocompatibility and the percentage cell viability was found to be above 89%. The FSC:PCF:MPE biocomposite film with required mechanical strength, biocompatibility and antimicrobial properties can be tried as a burn/wound dressing material. Copyright © 2012 Elsevier B.V. All rights reserved.

  14. Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease.

    Science.gov (United States)

    Ogino, Shuji; Lochhead, Paul; Chan, Andrew T; Nishihara, Reiko; Cho, Eunyoung; Wolpin, Brian M; Meyerhardt, Jeffrey A; Meissner, Alexander; Schernhammer, Eva S; Fuchs, Charles S; Giovannucci, Edward

    2013-04-01

    Epigenetics acts as an interface between environmental/exogenous factors, cellular responses, and pathological processes. Aberrant epigenetic signatures are a hallmark of complex multifactorial diseases (including neoplasms and malignancies such as leukemias, lymphomas, sarcomas, and breast, lung, prostate, liver, and colorectal cancers). Epigenetic signatures (DNA methylation, mRNA and microRNA expression, etc) may serve as biomarkers for risk stratification, early detection, and disease classification, as well as targets for therapy and chemoprevention. In particular, DNA methylation assays are widely applied to formalin-fixed, paraffin-embedded archival tissue specimens as clinical pathology tests. To better understand the interplay between etiological factors, cellular molecular characteristics, and disease evolution, the field of 'molecular pathological epidemiology (MPE)' has emerged as an interdisciplinary integration of 'molecular pathology' and 'epidemiology'. In contrast to traditional epidemiological research including genome-wide association studies (GWAS), MPE is founded on the unique disease principle, that is, each disease process results from unique profiles of exposomes, epigenomes, transcriptomes, proteomes, metabolomes, microbiomes, and interactomes in relation to the macroenvironment and tissue microenvironment. MPE may represent a logical evolution of GWAS, termed 'GWAS-MPE approach'. Although epigenome-wide association study attracts increasing attention, currently, it has a fundamental problem in that each cell within one individual has a unique, time-varying epigenome. Having a similar conceptual framework to systems biology, the holistic MPE approach enables us to link potential etiological factors to specific molecular pathology, and gain novel pathogenic insights on causality. The widespread application of epigenome (eg, methylome) analyses will enhance our understanding of disease heterogeneity, epigenotypes (CpG island methylator

  15. Protective effect of Mimosa pudica L. in an L-arginine model of acute necrotising pancreatitis in rats.

    Science.gov (United States)

    Kaur, Jagdeep; Sidhu, Shabir; Chopra, Kanwaljit; Khan, M U

    2016-07-01

    Mimosa pudica is used in traditional medicine for treating various disorders such as inflammatory conditions, diarrhoea, insomnia, alopecia, urogenital infections and wounds. The present study investigated the effect of M. pudica extract (MPE) on L-arginine-induced acute necrotising pancreatitis in rats. The ethanolic extract of M. pudica leaves was studied for the presence of quercetin and gallic acid using high-performance liquid chromatography. Four groups were employed-normal control rats, L-arginine control rats (two intraperitoneal [i.p.] injections of 2 g/kg at an interval of 1 h), MPE-treated rats (400 mg/kg orally) and melatonin-treated rats (positive control 10 mg/kg i.p.), which were further divided into subgroups according to time points (24 h, 3 days and 14 days). Serum amylase, lipase, tumour necrosis factor-α (TNF-α), pancreatic amylase, nucleic acid content, protein, transforming growth factor-β1 (TGF-β1), thiobarbituric reactive substances, glutathione, nitrite/nitrate, collagen content and histopathological examination were carried out. MPE significantly improved acute necrotising pancreatitis by modulating diagnostic markers of pancreatitis such as serum lipase and pancreatic amylase, inflammation (TNF-α), and oxidative and nitrosative stress. Moreover, MPE administration induced regenerative changes in the pancreas evidenced by increased levels of pancreatic proteins, nucleic acid content and histopathology report. In addition, MPE improved TGF-β1 and collagen levels thereby preventing fibrosis. The current investigation indicates the novel role of MPE in reducing the severity of acute necrotising pancreatitis by plausible mechanisms such as anti-inflammatory and anti-fibrotic activity and by promoting repair and regeneration of the pancreas.

  16. Review Article: The Role of Molecular Pathological Epidemiology in the Study of Neoplastic and Non-neoplastic Diseases in the Era of Precision Medicine.

    Science.gov (United States)

    Ogino, Shuji; Nishihara, Reiko; VanderWeele, Tyler J; Wang, Molin; Nishi, Akihiro; Lochhead, Paul; Qian, Zhi Rong; Zhang, Xuehong; Wu, Kana; Nan, Hongmei; Yoshida, Kazuki; Milner, Danny A; Chan, Andrew T; Field, Alison E; Camargo, Carlos A; Williams, Michelle A; Giovannucci, Edward L

    2016-07-01

    Molecular pathology diagnostics to subclassify diseases based on pathogenesis are increasingly common in clinical translational medicine. Molecular pathological epidemiology (MPE) is an integrative transdisciplinary science based on the unique disease principle and the disease continuum theory. While it has been most commonly applied to research on breast, lung, and colorectal cancers, MPE can investigate etiologic heterogeneity in non-neoplastic diseases, such as cardiovascular diseases, obesity, diabetes mellitus, drug toxicity, and immunity-related and infectious diseases. This science can enhance causal inference by linking putative etiologic factors to specific molecular biomarkers as outcomes. Technological advances increasingly enable analyses of various -omics, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, metagenomics, microbiome, immunomics, interactomics, etc. Challenges in MPE include sample size limitations (depending on availability of biospecimens or biomedical/radiological imaging), need for rigorous validation of molecular assays and study findings, and paucities of interdisciplinary experts, education programs, international forums, and standardized guidelines. To address these challenges, there are ongoing efforts such as multidisciplinary consortium pooling projects, the International Molecular Pathological Epidemiology Meeting Series, and the Strengthening the Reporting of Observational Studies in Epidemiology-MPE guideline project. Efforts should be made to build biorepository and biobank networks, and worldwide population-based MPE databases. These activities match with the purposes of the Big Data to Knowledge (BD2K), Genetic Associations and Mechanisms in Oncology (GAME-ON), and Precision Medicine Initiatives of the United States National Institute of Health. Given advances in biotechnology, bioinformatics, and computational/systems biology, there are wide open opportunities in MPE to contribute to public

  17. Østersølaks bedst til at afvise snyltere

    DEFF Research Database (Denmark)

    Buchmann, Kurt

    2006-01-01

    Danske forskere fra KVL har påvist at østersølaks er langt bedre end skotske laks til at bekæmpe de patogene parasitter ved navn Gyrodactylus salaris. Laks fra Skotland og Norge reagerer uhen sigtmæssigt, medens østersølaksen producerer relevante immunfaktorer.......Danske forskere fra KVL har påvist at østersølaks er langt bedre end skotske laks til at bekæmpe de patogene parasitter ved navn Gyrodactylus salaris. Laks fra Skotland og Norge reagerer uhen sigtmæssigt, medens østersølaksen producerer relevante immunfaktorer....

  18. Kinas nye mand vil korruptionen til livs

    DEFF Research Database (Denmark)

    Høyrup Christensen, Nis

    2013-01-01

    Kampen mod korruption er det første konkrete programpunkt, som Kinas nye mand i spidsen, Xi Jinping, har meldt ud. Dermed sender han et klart signal til de 80 millioner medlemmer i partiet og til den kæmpe administration, han er øverste chef for: Der skal handling til.......Kampen mod korruption er det første konkrete programpunkt, som Kinas nye mand i spidsen, Xi Jinping, har meldt ud. Dermed sender han et klart signal til de 80 millioner medlemmer i partiet og til den kæmpe administration, han er øverste chef for: Der skal handling til....

  19. Power Control at Grid Connected Converters and Analytical Solution of Steady States

    Czech Academy of Sciences Publication Activity Database

    Valouch, Viktor; Škramlík, Jiří; Muller, Z.; Švec, J.; Tlustý, J.

    2015-01-01

    Roč. 2015, September (2015), s. 1-12 ISSN 1024-123X Institutional support: RVO:61388998 Keywords : power control * converter * grid Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 0.644, year: 2015 http://downloads.hindawi.com/journals/mpe/2015/601916.pdf

  20. Intelligent bakteriebekæmpelse

    DEFF Research Database (Denmark)

    Givskov, Michael Christian

    2004-01-01

    En lovende metode til at bekæmpe bakterielle infektioner er populært sagt at forhindre forhindre bakterierne i at kommunikere med hinanden. Ved at hæmme bakteriernes kommunikationssystemer, kan man reducere ellers sygdomsfremkaldende bakterier til harmløse....

  1. The Magnetohydrodynamic Generator A Physics Olympiad Problem

    Indian Academy of Sciences (India)

    The Magnetohydrodynamic Generator A Physics Olympiad Problem (2001). Vijay A Singh ... Magnetohydrodynamics; generator; power; efficiency; Faraday's law; Physics Olympiad . Author Affiliations. Vijay A Singh1 Manish Kapoor2. Physics Department Indian Institute of Technology Kanpur 208016, India. MPE College ...

  2. Antioxidant capacity and radical scavenging effect of polyphenol rich Mallotus philippenensis fruit extract on human erythrocytes: an in vitro study.

    Science.gov (United States)

    Gangwar, Mayank; Gautam, Manish Kumar; Sharma, Amit Kumar; Tripathi, Yamini B; Goel, R K; Nath, Gopal

    2014-01-01

    Mallotus philippinensis is an important source of molecules with strong antioxidant activity widely used medicinal plant. Previous studies have highlighted their anticestodal, antibacterial, wound healing activities, and so forth. So, present investigation was designed to evaluate the total antioxidant activity and radical scavenging effect of 50% ethanol fruit glandular hair extract (MPE) and its role on Human Erythrocytes. MPE was tested for phytochemical test followed by its HPLC analysis. Standard antioxidant assays like DPPH, ABTS, hydroxyl, superoxide radical, nitric oxide, and lipid peroxidation assay were determined along with total phenolic and flavonoids content. Results showed that MPE contains the presence of various phytochemicals, with high total phenolic and flavonoid content. HPLC analysis showed the presence of rottlerin, a polyphenolic compound in a very rich quantity. MPE exhibits significant strong scavenging activity on DPPH and ABTS assay. Reducing power showed dose dependent increase in concentration absorption compared to standard, Quercetin. Superoxide, hydroxyl radical, lipid peroxidation, nitric oxide assay showed a comparable scavenging activity compared to its standard. Our finding further provides evidence that Mallotus fruit extract is a potential natural source of antioxidants which have a protective role on human Erythrocytes exhibiting minimum hemolytic activity and this justified its uses in folklore medicines.

  3. Defining the minimal important difference for the visual analogue scale assessing dyspnea in patients with malignant pleural effusions.

    Directory of Open Access Journals (Sweden)

    Eleanor K Mishra

    Full Text Available The minimal important difference (MID is essential for interpreting the results of randomised controlled trials (RCTs. Despite a number of RCTs in patients with malignant pleural effusions (MPEs which use the visual analogue scale for dyspnea (VASD as an outcome measure, the MID has not been established.Patients with suspected MPE undergoing a pleural procedure recorded their baseline VASD and their post-procedure VASD (24 hours after the pleural drainage, and in parallel assessed their breathlessness on a 7 point Likert scale.The mean decrease in VASD in patients with a MPE reporting a 'small but just worthwhile decrease' in their dyspnea (i.e. equivalent to the MID was 19mm (95% CI 14-24mm. The mean drainage volume required to produce a change in VASD of 19mm was 760ml.The mean MID for the VASD in patients with a MPE undergoing a pleural procedure is 19mm (95% CI 14-24mm. Thus choosing an improvement of 19mm in the VASD would be justifiable in the design and analysis of future MPE studies.

  4. Above- and Belowground Biomass Models for Trees in the Miombo Woodlands of Malawi

    Directory of Open Access Journals (Sweden)

    Daud J. Kachamba

    2016-02-01

    Full Text Available In this study we present general (multiple tree species from several sites above- and belowground biomass models for trees in the miombo woodlands of Malawi. Such models are currently lacking in the country. The modelling was based on 74 trees comprising 33 different species with diameters at breast height (dbh and total tree height (ht ranging from 5.3 to 2 cm and from 3.0 to 25.0 m, respectively. Trees were collected from four silvicultural zones covering a wide range of conditions. We tested different models including dbh, ht and wood specific gravity ( ρ as independent variables. We evaluated model performance using pseudo-R2, root mean square error (RMSE, a covariance matrix for the parameter estimates, mean prediction error (MPE and relative mean prediction error (MPE%. Computation of MPE% was based on leave-one-out cross-validation. Values of pseudo-R2 and MPE% ranged 0.82–0.97 and 0.9%–2.8%, respectively. Model performance indicated that the models can be used over a wide range of geographical and ecological conditions in Malawi.

  5. Shock Spectrum Calculation from Acceleration Time Histories

    Science.gov (United States)

    1980-09-01

    accurate and economical . If the velocity is desired, it can be calculated with Equation A-8b. As it stands it is exact. Approx- imation will be...Washington DC; DAEN-MCE.D (R L Wight) Washington DC; DAEN.MPE-D Washington DC; DAEN- MPU . Washington DC; DARCOM; ERADCOM Tech Supp Dir. (DELSD-L) Ft

  6. Chemsearch Journal Volume 4 Number 1, June, 2013

    African Journals Online (AJOL)

    Magashi

    2013-06-01

    Jun 1, 2013 ... Corrosion Inhibitors for Mild Steel in Hydrochloric Acid Solution. 1Ita, B. I., 1Louis ... ABSTRACT. The corrosion inhibition of mild steel in 2M hydrochloric acid solution by Melon (Cucumismelo)(MPE) and ..... halide ions in HCl.

  7. Ulighed i sundhed

    DEFF Research Database (Denmark)

    Uligheden i sundhed er stigende i Danmark trods et mangeårigt politisk fokus på at bekæmpe den. Bogen bidrager med viden om de komplekse processer, hvori ulighed i sundhed opstår og reproduceres. Bogens kapitler handler bl.a. om: Mænd og sundhed Klasse, sundhed og subjekt Overvægt Mental sundhed,...

  8. Cytomorphologic features of myxopapillary ependymoma: a review of 13 cases.

    Science.gov (United States)

    Takei, Hidehiro; Kosarac, Ognjen; Powell, Suzanne Z

    2009-01-01

    To describe the cytologic features of myxopapillary ependymoma (MPE) on intraoperative smears, to analyze cytomorphologic parameters that may help in reaching the diagnosis and to discuss differential diagnosis. Touch imprint smears of 13 MPE cases were reviewed and graded semiquantitatively for 14 cytomorphologic parameters; cellularity, myxoid background, isolated/dispersed tumor cells, "hyaline globules (HGs)," fibrillary cytoplasmic processes, papillary structures, perivascular pseudorosettes, epithelioid tumor cells (ETCs), intracytoplasmic mucin, intranuclear inclusions, nuclear grooves, mitosis, cytologic atypia and hemosiderin-laden macrophages. Cytologic examination revealed variably cellular specimens composed of isolated and loosely aggregated tumor cells with round to oval or occasionally spindle-shaped nuclei; evenly distributed, finely granular chromatin; and fibrillary processes admixed with occasional ETCs. Most of the cases showed prominent fibrillary processes and occasional ETCs with at least a focal myxoid background. HGs and hemosiderin-laden macrophages were often seen. Papillary structure, a histologic hallmark of MPE, was rarely observed. Dual glial and epithelioid properties of tumor cells, well-known features of "regular" ependymomas, and a distinctive myxoid background with HGs strongly support a diagnosis of MPE and are of great help in excluding other mimics (e.g., other variants of ependymoma, metastatic mucinous adenocarcinoma, metastatic adenoid cystic carcinoma and chordoma).

  9. The behavioral performance tests of Mucuna pruriens gold nanoparticles in the 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine treated mouse model of Parkinsonism

    Directory of Open Access Journals (Sweden)

    Subramanian Arulkumar

    2012-05-01

    Full Text Available Objective: The present investigation is aimed to carry out the behavioural changes of the Mucuna pruriens extract (MPE and Mucuna pruriens Goldnanoparticles (MPGNPs against MPTPinduced neurotoxicity. Methods: MPGNPs prepared from the methanolic extract of Mucuna pruriens seeds using Chloroauricchloride (HAuCl4. The seed powder has been found to show the anti-parkinsonian effects. Mice were induced with 10 mg/kg of MPTP, four injections i.p., at 1 h intervals within 24 h. MPE was administered at the dose 200 mg/kg (i.p and MPGNPs was administered at different doses of 500 毺 g/kg, 5, 10 and 20 mg/kg (i.p in different groups once a day for seven days and the dose on the first day was given 30 min prior to first MPTP injection. Results: The behavioural changes were studied using the rotarod test, hang test and narrow beam test. MPE and MPGNPs significantly (P<0.05 improved the behavioural activities. Conclusions: MPGNPs possesses significant behavioural activity than MPE against MPTP induced neurotoxicity.

  10. Pleurodesis Using Mistletoe Extract Delivered via a Spray Catheter during Semirigid Pleuroscopy for Managing Symptomatic Malignant Pleural Effusion.

    Science.gov (United States)

    Eom, Jung Seop; Ahn, Hyo Yeong; Mok, Jeong Ha; Lee, Geewon; Jo, Eun-Jung; Kim, Mi-Hyun; Lee, Kwangha; Kim, Ki Uk; Park, Hye-Kyung; Lee, Min Ki

    Talc poudrage during thoracoscopy is considered the standard procedure for patients with symptomatic malignant pleural effusion (MPE). Until now, no alternative technique other than talc poudrage for pleurodesis during medical thoracoscopy has been proposed. Liquid sclerosants, such as mistletoe extract, have been sprayed evenly into the pleural cavity during semirigid pleuroscopy for chemical pleurodesis. We conducted a retrospective study using the database of semirigid pleuroscopy to identify the usefulness of pleurodesis using a mistletoe extract delivered via a spray catheter during semirigid pleuroscopy for symptomatic MPE. All consecutive patients with symptomatic MPE who underwent semirigid pleuroscopy from October 2015 to September 2016 were registered. The responses were evaluated using chest X- ray or computed tomography 4 weeks after pleurodesis. The study included 43 patients who underwent pleurodesis with mistletoe extract via a spray catheter during semirigid pleuroscopy. Complete and partial responses were seen in 21 (49%) and 19 (44%) patients, respectively. The median duration of chest tube placement after pleurod-esis was 7 days (range 6-8 days) in the 40 patients with complete or partial responses. No cases of severe hemorrhage, empyema formation, respiratory failure, or procedure-related mortality were observed in the subjects at 4 weeks after semirigid pleuroscopy. Pleurodesis with mistletoe extract delivered via a spray catheter during semirigid pleuroscopy is a safe and effective procedure for managing symptomatic MPE. © 2017 S. Karger AG, Basel.

  11. Energy savings in cooling systems through use of new heat exchanger type with flat aluminium pipes and fins; Energibesparelser i koeleanlaeg ved anvendelse af ny varmevekslertype med flade aluminiumsroer og finner

    Energy Technology Data Exchange (ETDEWEB)

    Mulvad, R. (Aluventa A/S, Svendborg (Denmark)); Schneider, P. (Teknologisk Institut, Koele- og Varmepumpeteknik, AArhus (Denmark))

    2008-12-15

    This report describes the theoretical and practical work carried out to characterize and size air-cooled condensers and evaporators manufactured in MPE-tubes. Test heat exchangers were constructed for which capacity and pressure loss was measured. The measurements are compared with equations from the literature, and the most appropriate equations were selected. An analytical comparison of heat exchangers made with round tubes and fins of different types shows that by using heat exchangers with MPE-tubes and louvered fins lower air side pressure loss and higher performance can be achieved. Similarly, the refrigerant filling in MPE heat exchangers lower than in conventional heat exchangers with round tubes. This has great significance in the choice of heat exchangers because of the high price per kilo of HCF refrigerants. Correlations for heat transfer and pressure loss by condensation / evaporation and correlations for heat transfer and pressure drop were implemented in the calculation programs for design of condensers and evaporators. The calculation programs developed in the project are compared with a non-commercially available program designed for heat exchangers with MPE-tubes. The comparison shows good agreement. (ln)

  12. Romahadet er allemandseje i Danmark

    DEFF Research Database (Denmark)

    Molbæk-Steensig, Helga

    2017-01-01

    Artiklen adresserede politiets twitter-omtale af begrebet ’roma’ som synonym for ’omrejsende kriminel’. Artiklen gjorde opmærksom på Danmarks generelle og specifikke ansvar for at bekæmpe diskrimination, med henvisning til den europæiske menneskerettighedskonventions generelle diskriminationsforbud...

  13. 50 CFR 680.23 - Equipment and operational requirements.

    Science.gov (United States)

    2010-10-01

    ... States accessible by road or regularly scheduled air service; and (5) Provide an approved observer... operator must test each scale or scale system used to weigh CR crab one time during each 24-hour period... accurate and timely manner. (i) Belt scales. The MPE for the daily at-sea scale tests is plus or minus 3...

  14. Analytical Modeling and Simulation of Four-Switch Hybrid Power Filter Working with Sixfold Switching Symmetry

    Czech Academy of Sciences Publication Activity Database

    Tlustý, J.; Škramlík, Jiří; Švec, J.; Valouch, Viktor

    2012-01-01

    Roč. 2012, č. 292178 (2012), s. 1-17 ISSN 1024-123X Institutional support: RVO:61388998 Keywords : analytical modeling * four-switch hybrid power filter * sixfold switching symmetry Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 1.383, year: 2012 http://www.hindawi.com/journals/mpe/2012/292178/

  15. Exorcising the ghost of the past: The abandonment of obsession ...

    African Journals Online (AJOL)

    2011-06-21

    Jun 21, 2011 ... He goes on to point out that one of the many weaknesses in this approach .... as a contribution to a new genre of writing (the 'Hillbrow genre,' ... of women and children, crime, substance abuse, lack of respect for the next .... Mpe uses dialogue in Welcome to Our Hillbrowto try and offset such a victimisation.

  16. Implementation Guidance Document: Properties and Types of Significant Photothermal Retinal Lesion Injuries

    Science.gov (United States)

    2017-04-17

    Include area code) (703) 432-0899 Standard Form 298 (Rev. 8/98) Prescribed 1::r;< ANSI S1d. Z39.18 Adobe Professional 7 .O Properties and Types of...are above MPE yet well below an irradiance that could cause significant retinal injuries. Estimating RSI in Practice - Some Illustrative Examples

  17. Multiscale permutation entropy analysis of electrocardiogram

    Science.gov (United States)

    Liu, Tiebing; Yao, Wenpo; Wu, Min; Shi, Zhaorong; Wang, Jun; Ning, Xinbao

    2017-04-01

    To make a comprehensive nonlinear analysis to ECG, multiscale permutation entropy (MPE) was applied to ECG characteristics extraction to make a comprehensive nonlinear analysis of ECG. Three kinds of ECG from PhysioNet database, congestive heart failure (CHF) patients, healthy young and elderly subjects, are applied in this paper. We set embedding dimension to 4 and adjust scale factor from 2 to 100 with a step size of 2, and compare MPE with multiscale entropy (MSE). As increase of scale factor, MPE complexity of the three ECG signals are showing first-decrease and last-increase trends. When scale factor is between 10 and 32, complexities of the three ECG had biggest difference, entropy of the elderly is 0.146 less than the CHF patients and 0.025 larger than the healthy young in average, in line with normal physiological characteristics. Test results showed that MPE can effectively apply in ECG nonlinear analysis, and can effectively distinguish different ECG signals.

  18. Mikrobiologer ser bakterier i kortene

    DEFF Research Database (Denmark)

    Harmsen, Morten; Sternberg, Claus; Haagensen, Janus Anders Juul

    2008-01-01

    at klumpe sig sammen i slimede biofilm, som især er et stort problem på hospitalerne og hos patienter med kroniske infektioner. For at kunne bekæmpe biofi lm må forskerne vide mere om, hvorfor og hvordan filmen dannes. Ny viden inden for mikrobiologien og udviklingen af nanoteknologiske mikroskoper hjælper...

  19. Generalized composite multiscale permutation entropy and Laplacian score based rolling bearing fault diagnosis

    Science.gov (United States)

    Zheng, Jinde; Pan, Haiyang; Yang, Shubao; Cheng, Junsheng

    2018-01-01

    Multiscale permutation entropy (MPE) is a recently proposed nonlinear dynamic method for measuring the randomness and detecting the nonlinear dynamic change of time series and can be used effectively to extract the nonlinear dynamic fault feature from vibration signals of rolling bearing. To solve the drawback of coarse graining process in MPE, an improved MPE method called generalized composite multiscale permutation entropy (GCMPE) was proposed in this paper. Also the influence of parameters on GCMPE and its comparison with the MPE are studied by analyzing simulation data. GCMPE was applied to the fault feature extraction from vibration signal of rolling bearing and then based on the GCMPE, Laplacian score for feature selection and the Particle swarm optimization based support vector machine, a new fault diagnosis method for rolling bearing was put forward in this paper. Finally, the proposed method was applied to analyze the experimental data of rolling bearing. The analysis results show that the proposed method can effectively realize the fault diagnosis of rolling bearing and has a higher fault recognition rate than the existing methods.

  20. DNA Empresarial: Uma Análise da Gênese à Operação das Micro e Pequenas Empresas de Santa Catarina

    Directory of Open Access Journals (Sweden)

    Jackson André da Silva

    2014-01-01

    Full Text Available A presente pesquisa tem por objetivo analisar os fa tores ligados à gênese e à operação de Micro e Pequenas Empresas (MPE brasileiras, segund o a percepção dos dirigentes das MPE de Santa Catarina, Estado situado na Região Sul do Brasil, sendo esses fatores importantes para a competitividade e para a longevidade dessas firmas, desde as suas origens. O quadro teórico abrange o contexto das MPE no cenário brasi leiro e catarinense, bem como o levantamento dos fatores de sucesso/fracasso encont rados na literatura nacional e internacional. As percepções foram verificadas medi ante a aplicação de questionários estruturados. A partir do tratamento dos dados, obt eve-se o perfil das empresas e a identificação dos fatores que podem propiciar a com petitividade e a longevidade das MPE. Os resultados evidenciam que os dirigentes pesquisados são mais capazes de influenciar o sucesso do seu empreendimento, por meio da busca pe lo conhecimento do mercado, da habilidade em lidar com situações novas e pelo uso de instrumentos de controle administrativo, do que depender de fatores externos como o acesso a financiamentos, a redução do mercado e a concorrência.

  1. Relating Images, Concepts, and Words.

    Science.gov (United States)

    1979-01-01

    similarity metric and links fo r relatedness. Evidence from language for different kinds of mappings 4 In this section I present more detailed...ua ae mpe noa airpane nd amoutainfromthe tor " Pedo " i Wat Dineys Trasuy, Glde Press NowYork,1953 Page 16 Figure 4 "Collective invention" (1935) by Rene

  2. Plasticized chitosan/polyolefin films produced by extrusion.

    Science.gov (United States)

    Matet, Marie; Heuzey, Marie-Claude; Ajji, Abdellah; Sarazin, Pierre

    2015-03-06

    Plasticized chitosan and polyethylene blends were produced through a single-pass extrusion process. Using a twin-screw extruder, chitosan plasticization was achieved in the presence of an acetic acid solution and glycerol, and directly mixed with metallocene polyethylene, mPE, to produce a masterbatch. Different dilutions of the masterbatch (2, 5 and 10 wt% of plasticized chitosan), in the presence of ethylene vinyl acetate, EVA, were subsequently achieved in single screw film extrusion. Very small plasticized chitosan domains (number average diameter <5 μm) were visible in the polymeric matrix. The resulting films presented a brown color and increasing haze with chitosan plasticized content. Mechanical properties of the mPE films were affected by the presence of plasticized chitosan, but improvement was observed as a result of some compatibility between mPE and chitosan in the presence of EVA. Finally the incorporation of plasticized chitosan affected mPE water vapor permeability while oxygen permeability remained constant. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Ivan Vladislavić and What-What: Among Writers, Readers and “other ...

    African Journals Online (AJOL)

    This essay is an experimental quodlibet on some recent Johannesburg imaginative writing. It works outwards from a creative 'overview' of Ivan Vladislavić's position in South African literature to a perspective on versions of citiness represented by newer, black authors such as Niq Mhlongo and Phaswane Mpe. Unable to ...

  4. Simple principper for livet

    DEFF Research Database (Denmark)

    Knoop, Hans Henrik

    2010-01-01

    fremmer folks oplevelse af at kunne handle frit, ansvarligt, engageret og meningsfuldt - uanset hvem de er - hvilket betyder, at alle får mere energi, mere glæde, bedre processer og bedre resultater ved hjælp af princippet. Og hvis det forekommer besværligt at skulle bekæmpe meningsløsheden, kan man jo...

  5. Vascular Endothelial Growth Factor in Plasma and Pleural Effusion Is a Biomarker for Outcome After Bevacizumab plus Carboplatin-Paclitaxel Treatment for Non-small Cell Lung Cancer with Malignant Pleural Effusion.

    Science.gov (United States)

    Tamiya, Motohiro; Tamiya, Akihiro; Yasue, Tomomi; Nakao, Keiko; Omachi, Naoki; Shiroyama, Takayuki; Tani, Eriko; Hamaguchi, Masanari; Morishita, Naoko; Suzuki, Hidekazu; Okamoto, Norio; Okishio, Kyoichi; Kawaguchi, Tomoya; Atagi, Shinji; Hirashima, Tomonori

    2016-06-01

    Malignant effusion is associated with high serum and plasma levels of vascular endothelial growth factor (VEGF). There are no biomarkers of outcome for bevacizumab treatment in patients with malignant pleural effusion (MPE). We previously reported that carboplatin-paclitaxel plus bevacizumab was effective for patients with advanced non-squamous non-small cell lung cancer (NSCLC) and MPE, although we did not evaluate the relationship between treatment outcomes and plasma or pleural effusion levels of VEGF. Therefore, this study evaluated whether plasma or pleural effusion VEGF might predict bevacizumab treatment outcome. We enrolled 23 patients with NSCLC and MPE between September 2010 and June 2012. Plasma VEGF levels were measured in 19 patients and pleural VEGF levels were measured in 22 patients. Compared to patients with a low plasma VEGF level, patients with a high level exhibited significantly shorter overall survival (OS: 13.8 vs. 6.5 months, p=0.04), progression-free survival (PFS: 8.7 vs. 4.8 months, peffusion, patients with a high VEGF level exhibited significantly shorter OS (19.6 vs. 6.9 months, peffusion may predict the outcome of bevacizumab treatment in patients with NSCLC and MPE. Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  6. Elevated pleural effusion IL-17 is a diagnostic marker and outcome predictor in lung cancer patients

    Science.gov (United States)

    2014-01-01

    Background Interleukin 17 (IL-17) is a proinflammatory cytokine produced mainly by CD4+ T-lymphocytes and may be important in tumor cell growth and progression. In this study, we aimed to evaluate the diagnostic and prognostic value of pleural effusion levels of IL-17 in lung cancer patients with malignant pleural effusion (MPE). Methods Pleural effusion samples were collected from 78 lung cancer patients with MPE and from 45 patients with nonmalignant pleural effusion. Pleural fluid concentrations of IL-17 were measured by using enzyme-linked immunosorbent assays. Results Malignant effusion exhibited higher IL-17 levels than nonmalignant effusion (20.49 ± 5.27 pg/ml vs. 13.16 ± 2.25 pg/ml; P < 0.01). Lung cancer patients with pleural fluid IL-17 levels below 15 pg/ml had longer overall survival than those patients with higher levels (10.8 months vs. 4.7 months; P < 0.05). On the basis of multivariate analysis, we found that pleural fluid IL-17 level was an independent prognostic factor in lung cancer patients with MPE. Conclusions Measurement of IL-17 levels might be a useful diagnostic and prognostic test for lung cancer patients with MPE. PMID:24887477

  7. Management of malignant pleural effusion

    NARCIS (Netherlands)

    Boshuizen, R.C.

    2017-01-01

    The first part of this thesis focuses on IPCs (indwelling pleural catheters) in malignant pleural effusion (MPE) management. In an invited review, the (dis)advantages and prejudices of IPCs are described (Chapter1.1). Since costs and reimbursement issues are the main reasons in the Netherlands to

  8. Integration of molecular pathology, epidemiology and social science for global precision medicine.

    Science.gov (United States)

    Nishi, Akihiro; Milner, Danny A; Giovannucci, Edward L; Nishihara, Reiko; Tan, Andy S; Kawachi, Ichiro; Ogino, Shuji

    2016-01-01

    The precision medicine concept and the unique disease principle imply that each patient has unique pathogenic processes resulting from heterogeneous cellular genetic and epigenetic alterations and interactions between cells (including immune cells) and exposures, including dietary, environmental, microbial and lifestyle factors. As a core method field in population health science and medicine, epidemiology is a growing scientific discipline that can analyze disease risk factors and develop statistical methodologies to maximize utilization of big data on populations and disease pathology. The evolving transdisciplinary field of molecular pathological epidemiology (MPE) can advance biomedical and health research by linking exposures to molecular pathologic signatures, enhancing causal inference and identifying potential biomarkers for clinical impact. The MPE approach can be applied to any diseases, although it has been most commonly used in neoplastic diseases (including breast, lung and colorectal cancers) because of availability of various molecular diagnostic tests. However, use of state-of-the-art genomic, epigenomic and other omic technologies and expensive drugs in modern healthcare systems increases racial, ethnic and socioeconomic disparities. To address this, we propose to integrate molecular pathology, epidemiology and social science. Social epidemiology integrates the latter two fields. The integrative social MPE model can embrace sociology, economics and precision medicine, address global health disparities and inequalities, and elucidate biological effects of social environments, behaviors and networks. We foresee advancements of molecular medicine, including molecular diagnostics, biomedical imaging and targeted therapeutics, which should benefit individuals in a global population, by means of an interdisciplinary approach of integrative MPE and social health science.

  9. Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.

    Science.gov (United States)

    McCormack, Mark; Gui, Hongsheng; Ingason, Andrés; Speed, Doug; Wright, Galen E B; Zhang, Eunice J; Secolin, Rodrigo; Yasuda, Clarissa; Kwok, Maxwell; Wolking, Stefan; Becker, Felicitas; Rau, Sarah; Avbersek, Andreja; Heggeli, Kristin; Leu, Costin; Depondt, Chantal; Sills, Graeme J; Marson, Anthony G; Auce, Pauls; Brodie, Martin J; Francis, Ben; Johnson, Michael R; Koeleman, Bobby P C; Striano, Pasquale; Coppola, Antonietta; Zara, Federico; Kunz, Wolfram S; Sander, Josemir W; Lerche, Holger; Klein, Karl Martin; Weckhuysen, Sarah; Krenn, Martin; Gudmundsson, Lárus J; Stefánsson, Kári; Krause, Roland; Shear, Neil; Ross, Colin J D; Delanty, Norman; Pirmohamed, Munir; Carleton, Bruce C; Cendes, Fernando; Lopes-Cendes, Iscia; Liao, Wei-Ping; O'Brien, Terence J; Sisodiya, Sanjay M; Cherny, Stacey; Kwan, Patrick; Baum, Larry; Cavalleri, Gianpiero L

    2018-01-23

    To characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cutaneous adverse drug reaction common to antiepileptic drugs. We conducted a case-control genome-wide association study of autosomal genotypes, including Class I and II human leukocyte antigen (HLA) alleles, in 323 cases and 1,321 drug-tolerant controls from epilepsy cohorts of northern European and Han Chinese descent. Results from each cohort were meta-analyzed. We report an association between a rare variant in the complement factor H-related 4 ( CFHR4 ) gene and phenytoin-induced MPE in Europeans ( p = 4.5 × 10 -11 ; odds ratio [95% confidence interval] 7 [3.2-16]). This variant is in complete linkage disequilibrium with a missense variant (N1050Y) in the complement factor H ( CFH ) gene. In addition, our results reinforce the association between HLA-A*31:01 and carbamazepine hypersensitivity. We did not identify significant genetic associations with MPE among Han Chinese patients. The identification of genetic predictors of MPE in CFHR4 and CFH, members of the complement factor H-related protein family, suggest a new link between regulation of the complement system alternative pathway and phenytoin-induced hypersensitivity in European-ancestral patients. Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

  10. [The value of B7-H4 and carcinoembryonic antigen in diagnosing the benign and malignant pleural effusion].

    Science.gov (United States)

    Wei, F; Wei, Y; Li, L F; Li, G L; Wang, G J

    2017-07-23

    Objective: To evaluate the value of combined detection of negative costimulatory molecule B7-H4 and carcinoembryonic antigen (CEA) in diagnosing malignant and benign pleural effusion. Methods: Ninety-seven pleural effusion specimen were collected, 55 of which were diagnosed as malignant pleural effusion and 42 were benign pleural effusion. Enzyme-linked immunosorbent assay(ELISA) was used to examine the concentration of B7-H4 and CEA in pleural effusion. Electro-chemiluminescence immunoassay was used to detect the CEA level in pleural effusion. Receiver operating characteristic (ROC) curve was established to analyze and evaluate the single or combined detection of B7-H4 and CEA in diagnosing malignant and benign pleural effusion. Results: The concentrations of B7-H4 and CEA in malignant pleural effusion (MPE) group were (60.08±35.04) ng/ml and (41.49±37.16) ng/ml, respectively, obviously higher than (27.26±9.55) ng/ml and (2.41±0.94) ng/ml of benign pleural effusion (BPE) group (both P 37.25 ng/ml or CEA>4.18 ng/ml, the sensitivity of diagnosis as MPE was down-regulated to 90.9% and the specificity was elevated to 88.1%. When B7-H4 >37.25 ng/ml and CEA>4.18 ng/ml, the sensitivity of diagnosis as MPE was down-regulated to 78.2% and the specificity was elevated to 97.6%. The sensitivity and specificity of combined detection of B7-H4 and CEA to diagnose MPE were elevated to 90.9% and 97.6%, respectively. The level of B7-H4 in MPE and BPE were both positively correlated with CEA ( r =0.670, P =0.001 in MPE and r =0.002, P =0.001 in BEP). Conclusions: B7-H4 is a potential tumor marker in diagnosing the benign and malignant pleural effusion. Although the diagnostic value of B7-H4 may not precede to CEA, the combined detection of B7-H4 and CEA can improve the diagnostic sensitivity and specificity of MPE.

  11. Efficacy of sonographic and biological pleurodesis indicators of malignant pleural effusion (SIMPLE): protocol of a randomised controlled trial

    Science.gov (United States)

    Piotrowska, Hania E G; Yousuf, Ahmed; Kanellakis, Nikolaos I; Kagithala, Gayathri; Mohammed, Seid; Clifton, Lei; Corcoran, John P; Russell, Nicky; Dobson, Melissa; Miller, Robert F; Rahman, Najib M

    2017-01-01

    Introduction Malignant pleural effusion (MPE) is common and currently in UK there are an estimated 50 000 new cases of MPE per year. Talc pleurodesis remains one of the most popular methods for fluid control. The value of thoracic ultrasound (TUS) imaging, before and after pleurodesis, in improving the quality and efficacy of care for patients with MPE remains unknown. Additionally, biomarkers of successful pleurodesis including measurement of pleural fluid proteins have not been validated in prospective studies. The SIMPLE trial is an appropriately powered, multicentre, randomised controlled trial designed to assess ’by the patient bedside' use of TUS imaging and pleural fluid analysis in improving management of MPE. Methods and analysis 262 participants with a confirmed MPE requiring intervention will be recruited from hospitals in UK and The Netherlands. Participants will be randomised (1:1) to undergo either chest drain insertion followed by instillation of sterile talc, or medical thoracoscopy and simultaneous poudrage. The allocated procedure will be done while the patient is hospitalised, and within 3 days of randomisation. Following hospital discharge, participants will be followed up at 1, 3 and 12 months. The primary outcome measure is the length of hospital stay during initial hospitalisation. Ethics and dissemination The trial has received ethical approval from the South Central-Oxford C Research Ethics Committee (Reference number 15/SC/0600). The Trial Steering Committee includes an independent chair and members, and a patient representative. The trial results will be published in a peer-reviewed journal and presented at international conferences. Trial registration number ISRCTN: 16441661. PMID:29225889

  12. Plasma and pleural fluid pharmacokinetics of erlotinib and its active metabolite OSI-420 in patients with non-small-cell lung cancer with pleural effusion.

    Science.gov (United States)

    Masago, Katsuhiro; Togashi, Yosuke; Fukudo, Masahide; Terada, Tomohiro; Irisa, Kaoru; Sakamori, Yuichi; Kim, Young Hak; Mio, Tadashi; Inui, Ken-Ichi; Mishima, Michiaki

    2011-09-01

    Erlotinib is orally active and selectively inhibits the tyrosine kinase activity of the epidermal growth factor receptor. The pleural space penetration and exposure of erlotinib is poorly understood. Thus, we investigated the pharmacokinetics (PK) of erlotinib and its active metabolite OSI-420 in non-small-cell lung cancer (NSCLC) of malignant pleural effusion (MPE). We analyzed the PK of erlotinib and OSI-420 on days 1 and 8 after beginning erlotinib therapy in 9 patients with MPE. Their concentrations were determined by high-performance liquid chromatography with ultraviolet detection. Blood samples were obtained five times per day: before administration, and 2, 4, 8, and 24 hours after administration. Pleural effusions were obtained once per day, 2 hours after administration on day 1, and before administration on day 8. The exceptions were cases 2 and 4, which had pleural effusions obtained just before drug administration, and 2, 4, 8, and 24 hours after administration. The mean percentage of penetration from plasma to pleural effusion for erlotinib was 18% on day 1 and 112% on day 8, while these values for OSI-420 were 9.5% on day 1 and 131% on day 8. The area under the drug concentration-time curve of pleural fluid for erlotinib was 28,406 ng-hr/mL for case 2 and 45,906 ng-hr/mL for case 4. There seems to be a significant accumulation of both erlotinib and OSI-420 in MPE with repeated dosing. Although larger studies will be necessary to determine the true impact of erlotinib MPE accumulation on plasma PK and safety, erlotinib can be administered safely to patients with MPE with respect to efficacy and side effects. Copyright © 2011. Published by Elsevier Inc.

  13. Management of Pediatric Myxopapillary Ependymoma: The Role of Adjuvant Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Agbahiwe, Harold C.; Wharam, Moody [Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Batra, Sachin [Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Cohen, Kenneth [Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Terezakis, Stephanie A., E-mail: sterezak@jhmi.edu [Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States)

    2013-02-01

    Introduction: Myxopapillary ependymoma (MPE) is a rare tumor in children. The primary treatment is gross total resection (GTR), with no clearly defined role for adjuvant radiation therapy (RT). Published reports, however, suggest that children with MPE present with a more aggressive disease course. The goal of this study was to assess the role of adjuvant RT in pediatric patients with MPE. Methods: Sixteen patients with MPE seen at Johns Hopkins Hospital (JHH) between November 1984 and December 2010 were retrospectively reviewed. Fifteen of the patients were evaluable with a mean age of 16.8 years (range, 12-21 years). Kaplan-Meier curves and descriptive statistics were used for analysis. Results: All patients received surgery as the initial treatment modality. Surgery consisted of either a GTR or a subtotal resection (STR). The median dose of adjuvant RT was 50.4 Gy (range, 45-54 Gy). All patients receiving RT were treated at the involved site. After a median follow-up of 7.2 years (range, 0.75-26.4 years), all patients were alive with stable disease. Local control at 5 and 10 years was 62.5% and 30%, respectively, for surgery alone versus 100% at both time points for surgery and adjuvant RT. Fifty percent of the patients receiving surgery alone had local failure. All patients receiving STR alone had local failure compared to 33% of patients receiving GTR alone. One patient in the surgery and adjuvant RT group developed a distant site of recurrence 1 year from diagnosis. No late toxicity was reported at last follow-up, and neurologic symptoms either improved or remained stable following surgery with or without RT. Conclusions: Adjuvant RT improved local control compared to surgery alone and should be considered after surgical resection in pediatric patients with MPE.

  14. Motor Planning Error: Toward Measuring Cognitive Frailty in Older Adults Using Wearables

    Directory of Open Access Journals (Sweden)

    He Zhou

    2018-03-01

    Full Text Available Practical tools which can be quickly administered are needed for measuring subtle changes in cognitive–motor performance over time. Frailty together with cognitive impairment, or ‘cognitive frailty’, are shown to be strong and independent predictors of cognitive decline over time. We have developed an interactive instrumented trail-making task (iTMT platform, which allows quantification of motor planning error (MPE through a series of ankle reaching tasks. In this study, we examined the accuracy of MPE in identifying cognitive frailty in older adults. Thirty-two older adults (age = 77.3 ± 9.1 years, body-mass-index = 25.3 ± 4.7 kg/m2, female = 38% were recruited. Using either the Mini-Mental State Examination or Montreal Cognitive Assessment (MoCA, 16 subjects were classified as cognitive-intact and 16 were classified as cognitive-impaired. In addition, 12 young-healthy subjects (age = 26.0 ± 5.2 years, body-mass-index = 25.3 ± 3.9 kg/m2, female = 33% were recruited to establish a healthy benchmark. Subjects completed the iTMT, using an ankle-worn sensor, which transforms ankle motion into navigation of a computer cursor. The iTMT task included reaching five indexed target circles (including numbers 1-to-3 and letters A&B placed in random order on the computer-screen by moving the ankle-joint while standing. The ankle-sensor quantifies MPE through analysis of the pattern of ankle velocity. MPE was defined as percentage of time deviation between subject’s maximum ankle velocity and the optimal maximum ankle velocity, which is halfway through the reaching pathway. Data from gait tests, including single task and dual task walking, were also collected to determine cognitive–motor performance. The average MPE in young-healthy, elderly cognitive-intact, and elderly cognitive-impaired groups was 11.1 ± 5.7%, 20.3 ± 9.6%, and 34.1 ± 4.2% (p < 0.001, respectively. Large effect sizes (Cohen’s d = 1.17–4.56 were observed for

  15. A Importância do Planejamento Tributário nas Micro e Pequenas Empresas

    Directory of Open Access Journals (Sweden)

    Lucilaine Escobar Teixeira Sampaio

    2015-06-01

    Full Text Available O objetivo geral deste estudo é demonstrar a importância do planejamento tributário para as micro e pequenas empresas (MPE no Brasil. Já os alvos específicos são: identificar as formas de tributação existentes que podem ser utilizadas pelas MPE e verificar qual é a mais viável. Para atingir os objetivos deste estudo, foi realizada pesquisa bibliográfica a partir de artigos e livros do acervo da Faculdade Anhanguera, da Universidade Católica Dom Bosco (UCDB e de acervos pessoais, bem como de artigos de periódicos e legislação disponíveis na internet e manuais de pesquisa no site do Serviço Brasileiro de Apoio às Micro e Pequenas Empresas (Sebrae. Dos resultados encontrados, verificou-se que as MPE possuem papel relevante para a economia e, por esse motivo, o governo, nas últimas décadas, tem proporcionado vários incentivos visando estimular a abertura de mais empresas desse porte, bem como evitar que muitas entrem em falência, tendo em vista que pesquisas realizadas, principalmente pelo Sebrae, demonstram que é alto o índice de MPE que entram em falência todos os anos. Nas últimas décadas, após os incentivos adotados, entre eles a criação do Simples, nova forma de tributação especial para as MPE, verificou-se uma redução no fechamento de empresas desse porte, porém, o índice continua elevado. Várias são as causas para a falência das MPE, e dentre elas se destaca a alta carga tributária. Dessa forma, torna-se imprescindível que os empresários invistam na realização do planejamento tributário, a fim de escolher a melhor forma de tributação para evitar a falência.

  16. Development and validation of a medical chart review checklist for symptom management performance of oncologists in the routine care of patients with advanced cancer.

    Science.gov (United States)

    Blum, David; Rosa, Daniel; deWolf-Linder, Susanne; Hayoz, Stefanie; Ribi, Karin; Koeberle, Dieter; Strasser, Florian

    2014-12-01

    Oncologists perform a range of pharmacological and nonpharmacological interventions to manage the symptoms of outpatients with advanced cancer. The aim of this study was to develop and test a symptom management performance checklist (SyMPeC) to review medical charts. First, the content of the checklist was determined by consensus of an interprofessional team. The SyMPeC was tested using the data set of the SAKK 96/06 E-MOSAIC (Electronical Monitoring of Symptoms and Syndromes Associated with Cancer) trial, which included six consecutive visits from 247 patients. In a test data set (half of the data) of medical charts, two people extracted and quantified the definitions of the parameters (content validity). To assess the inter-rater reliability, three independent researchers used the SyMPeC on a random sample (10% of the test data set), and Fleiss's kappa was calculated. To test external validity, the interventions retrieved by the SyMPeC chart review were compared with nurse-led assessment of patient-perceived oncologists' palliative interventions. Five categories of symptoms were included: pain, fatigue, anorexia/nausea, dyspnea, and depression/anxiety. Interventions were categorized as symptom specific or symptom unspecific. In the test data set of 123 patients, 402 unspecific and 299 symptom-specific pharmacological interventions were detected. Nonpharmacological interventions (n = 242) were mostly symptom unspecific. Fleiss's kappa for symptom and intervention detections was K = 0.7 and K = 0.86, respectively. In 1003 of 1167 visits (86%), there was a match between SyMPeC and nurse-led assessment. Seventy-nine percent (195 of 247) of patients had no or one mismatch. Chart review by SyMPeC seems reliable to detect symptom management interventions by oncologists in outpatient clinics. Nonpharmacological interventions were less symptom specific. A template for documentation is needed for standardization. Copyright © 2014 American Academy of Hospice and

  17. Comparison of NEXRAD multisensor precipitation estimates to rain gage observations in and near DuPage County, Illinois, 2002–12

    Science.gov (United States)

    Spies, Ryan R.; Over, Thomas M.; Ortel, Terry W.

    2018-05-21

    In this report, precipitation data from 2002 to 2012 from the hourly gridded Next-Generation Radar (NEXRAD)-based Multisensor Precipitation Estimate (MPE) precipitation product are compared to precipitation data from two rain gage networks—an automated tipping bucket network of 25 rain gages operated by the U.S. Geological Survey (USGS) and 51 rain gages from the volunteer-operated Community Collaborative Rain, Hail, and Snow (CoCoRaHS) network—in and near DuPage County, Illinois, at a daily time step to test for long-term differences in space, time, and distribution. The NEXRAD–MPE data that are used are from the fifty 2.5-mile grid cells overlying the rain gages from the other networks. Because of the challenges of measuring of frozen precipitation, the analysis period is separated between days with or without the chance of freezing conditions. The NEXRAD–MPE and tipping-bucket rain gage precipitation data are adjusted to account for undercatch by multiplying by a previously determined factor of 1.14. Under nonfreezing conditions, the three precipitation datasets are broadly similar in cumulative depth and distribution of daily values when the data are combined spatially across the networks. However, the NEXRAD–MPE data indicate a significant trend relative to both rain gage networks as a function of distance from the NEXRAD radar just south of the study area. During freezing conditions, of the USGS network rain gages only the heated gages were considered, and these gages indicate substantial mean undercatch of 50 and 61 percent compared to the NEXRAD–MPE and the CoCoRaHS gages, respectively. The heated USGS rain gages also indicate substantially lower quantile values during freezing conditions, except during the most extreme (highest) events. Because NEXRAD precipitation products are continually evolving, the report concludes with a discussion of recent changes in those products and their potential for improved precipitation estimation. An appendix

  18. Diagnostic value of soluble receptor-binding cancer antigen expressed on SiSo cells and carcinoembryonic antigen in differentiating malignant from benign pleural effusion.

    Science.gov (United States)

    Dong, Jiahui; Sun, Gengyun; Zhu, Hongbin

    2016-03-01

    Diagnosis of malignant pleural effusion (MPE) remains a major clinical challenge. The aim of this study was to evaluate the diagnostic value of combined detection of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) and carcinoembryonic antigen (CEA) in patients with MPE and benign pleural effusion (BPE). The serum and pleural fluid samples were collected from 53 patients diagnosed with MPE and 49 patients with BPE. Enzyme-linked immunosorbent assay was used to detect the concentration of RCAS1 in serum and pleural effusion. The clinical data and laboratory information, including CEA levels, were gathered from these cases. The concentration of RCAS1 in MPE was significantly higher than that of BPE (P < 0.001). There was no significant difference between the two serum groups. The diagnostic sensitivity and specificity of pleural fluid RCAS1 were 67.92 and 81.63 %, respectively, at the optimized cutoff value of 7.326 U/mL; meanwhile, the sensitivity and specificity of pleural fluid CEA were 83.02 and 91.84 % at the cutoff value of 3.93 ng/mL. The specificity could be elevated to 98.50 % in serial detection, while the sensitivity may be improved to 94.55 % in parallel detection. Serum RCAS1 concentration was only detected in 53 serum samples out of the 102 samples, indicating that serum RCAS1 may not be a better option in differential diagnosis of malignancies compared with serum CEA, of which the diagnostic sensitivity and specificity were 64.15 and 83.67 % at the cutoff value of 3.90 ng/mL. No significant differences were found in pleural fluid RCAS1 concentration in MPE patients with different ages, gender, and pathological types of lung cancers. The detection of RCAS1 concentration in pleural fluid is informative for the diagnosis of MPE. Joint detection of RCAS1 and CEA can improve the diagnostic sensitivity and specificity. However, the diagnostic value of RCAS1 is not higher than that of CEA.

  19. Cross-Validation of a Glucose-Insulin-Glucagon Pharmacodynamics Model for Simulation using Data from Patients with Type 1 Diabetes

    DEFF Research Database (Denmark)

    Wendt, Sabrina Lyngbye; Ranjan, Ajenthen; Møller, Jan Kloppenborg

    2017-01-01

    three PD model test fits in each of the seven subjects. Thus, we successfully validated the PD model by leave-one-out cross-validation in seven out of eight T1D patients. Conclusions: The PD model accurately simulates glucose excursions based on plasma insulin and glucagon concentrations. The reported...... for concentrations of glucagon, insulin, and glucose. We fitted pharmacokinetic (PK) models to insulin and glucagon data using maximum likelihood and maximum a posteriori estimation methods. Similarly, we fitted a pharmacodynamic (PD) model to glucose data. The PD model included multiplicative effects of insulin...... and glucagon on EGP. Bias and precision of PD model test fits were assessed by mean predictive error (MPE) and mean absolute predictive error (MAPE). Results: Assuming constant variables in a subject across nonoutlier visits and using thresholds of ±15% MPE and 20% MAPE, we accepted at least one and at most...

  20. Effect of synthetic mica on the thermal properties of poly(lactic acid

    Directory of Open Access Journals (Sweden)

    Diego Holanda Saboya Souza

    2014-01-01

    Full Text Available Poly(lactic acid/Somasif fluoromica nanocomposites were prepared by melt blending and their thermal properties investigated by DSC, TGA and DMA. Three different types of synthetic mica (Somasif ME-100, Somasif MAE and Somasif MPE were used at different contents (2.5, 5.0 and 7.5 wt %. The melt blending of PLA and these micas is characterized by a considerable reduction in the matrix molecular weight, which decreases when the nanofiller content is increased. For all nanocomposites, the thermal stability increases when mica is added to the polymer, with the Somasif MPE, producing the highest increase of the degradation temperature and highest reduction of Tg.

  1. NASA/Max Planck Institute Barium Ion Cloud Project.

    Science.gov (United States)

    Brence, W. A.; Carr, R. E.; Gerlach, J. C.; Neuss, H.

    1973-01-01

    NASA and the Max Planck Institute for Extraterrestrial Physics (MPE), Munich, Germany, conducted a cooperative experiment involving the release and study of a barium cloud at 31,500 km altitude near the equatorial plane. The release was made near local magnetic midnight on Sept. 21, 1971. The MPE-built spacecraft contained a canister of 16 kg of Ba CuO mixture, a two-axis magnetometer, and other payload instrumentation. The objectives of the experiment were to investigate the interaction of the ionized barium cloud with the ambient medium and to deduce the properties of electric fields in the proximity of the release. An overview of the project is given to briefly summarize the organization, responsibilities, objectives, instrumentation, and operational aspects of the project.

  2. Melanin microcavitation threshold in the near infrared

    Science.gov (United States)

    Schmidt, Morgan S.; Kennedy, Paul K.; Vincelette, Rebecca L.; Schuster, Kurt J.; Noojin, Gary D.; Wharmby, Andrew W.; Thomas, Robert J.; Rockwell, Benjamin A.

    2014-02-01

    Thresholds for microcavitation of isolated bovine and porcine melanosomes were determined using single nanosecond (ns) laser pulses in the NIR (1000 - 1319 nm) wavelength regime. Average fluence thresholds for microcavitation increased non-linearly with increasing wavelength. Average fluence thresholds were also measured for 10-ns pulses at 532 nm, and found to be comparable to visible ns pulse values published in previous reports. Fluence thresholds were used to calculate melanosome absorption coefficients, which decreased with increasing wavelength. This trend was found to be comparable to the decrease in retinal pigmented epithelial (RPE) layer absorption coefficients reported over the same wavelength region. Estimated corneal total intraocular energy (TIE) values were determined and compared to the current and proposed maximum permissible exposure (MPE) safe exposure levels. Results from this study support the proposed changes to the MPE levels.

  3. Modellen

    DEFF Research Database (Denmark)

    Om genopførelsen af Palle Nielsens (f. 1942) værk Modellen fra 1968: en kæmpe legeplads til børn i museet, hvor de kan boltre sig frit: klatre i tove, kravle i trækonstruktioner, arbejde med værktøjer, kaste sig ud i skumgummipuder, male med fingermaling og klæde sig ud i kostumer......Om genopførelsen af Palle Nielsens (f. 1942) værk Modellen fra 1968: en kæmpe legeplads til børn i museet, hvor de kan boltre sig frit: klatre i tove, kravle i trækonstruktioner, arbejde med værktøjer, kaste sig ud i skumgummipuder, male med fingermaling og klæde sig ud i kostumer...

  4. Management of malignant pleural effusion: challenges and solutions

    Science.gov (United States)

    Penz, Erika; Watt, Kristina N; Hergott, Christopher A; Rahman, Najib M; Psallidas, Ioannis

    2017-01-01

    Malignant pleural effusion (MPE) is a sign of advanced cancer and is associated with significant symptom burden and mortality. To date, management has been palliative in nature with a focus on draining the pleural space, with therapies aimed at preventing recurrence or providing intermittent drainage through indwelling catheters. Given that patients with MPEs are heterogeneous with respect to their cancer type and response to systemic therapy, functional status, and pleural milieu, response to MPE therapy is also heterogeneous and difficult to predict. Furthermore, the impact of therapies on important patient outcomes has only recently been evaluated consistently in clinical trials and cohort studies. In this review, we examine patient outcomes that have been studied to date, address the question of which are most important for managing patients, and review the literature related to the expected value for money (cost-effectiveness) of indwelling pleural catheters relative to traditionally recommended approaches. PMID:28694705

  5. QPS/LHC Activities requiring important Tunnel Work During a future long Shutdown

    CERN Document Server

    Dahlerup-Petersen, K

    2011-01-01

    The MPE/circuit protection section is presently establishing a road map for its future LHC activities. The tasks comprise essential consolidation work, compulsory upgrades and extensions of existing machine facilities. The results of a first round of engineering exertion were presented and evaluated at a MPE activity review in December 2010. The technical and financial aspects of this program will be detailed in the ‘QPS Medium and Long-Term Improvement Plan’, to be published shortly. The QPS activities in the LHC tunnel during a future, long shutdown are closely related to this improvement chart. A project-package based program for the interventions has been established and will be presented in this report, together with estimates for the associated human and financial resources necessary for its implementation.

  6. Mathematical Modelling of Optimization of Structures of Monolithic Coverings Based on Liquid Rubbers

    Science.gov (United States)

    Turgumbayeva, R. Kh; Abdikarimov, M. N.; Mussabekov, R.; Sartayev, D. T.

    2018-05-01

    The paper considers optimization of monolithic coatings compositions using a computer and MPE methods. The goal of the paper was to construct a mathematical model of the complete factorial experiment taking into account its plan and conditions. Several regression equations were received. Dependence between content components and parameters of rubber, as well as the quantity of a rubber crumb, was considered. An optimal composition for manufacturing the material of monolithic coatings compositions was recommended based on experimental data.

  7. Spinal tuberculoma in a patient with spinal myxopapillary ependymoma

    Directory of Open Access Journals (Sweden)

    Arora Brijesh

    2010-01-01

    Full Text Available Intramedullary spinal tuberculosis is a clinical curiosity. A 19-year-old female was diagnosed and treated for lumbosacral myxopapllary ependy moma (MPE. Three years later, she presented with back pain and hypoesthesia of the left upper limb. Besides revealing local recurrence, the MRI demonstrated a fresh lesion in the cervicomedullary area. The latter was operated and the histopathology revealed a tuberculoma.

  8. Acquisition Of Rainfall Dataset And The Application For The Automatic Harvester In The Chesapeake Bay Region

    Science.gov (United States)

    Choi, Y.; Piasecki, M.

    2008-12-01

    The objective of this study is the preparation and indexing of rainfall data products for ingestion into the Chesapeake Bay Environmental Observatory (CBEO) node of the CUAHSI/WATERs network. Rainfall products (which are obtained and then processed based on the WSR-88D NEXRAD network) are obtained from the NOAA/NWS Advanced Hydrologic Prediction Service that combines the Multi-sensor Precipitation Estimate (MPE) data generated by the Regional River Forecast Centers and Hydro-NEXRAD rainfall data generated as a service by the University of Iowa. The former is collected on 4*4 km grid (HRAP) with a daily average temporal resolution and the latter on a 1minute*1minute degree grid with hourly values. We have generated a cut-out for the Chesapeake Bay Basin that contains about 9,300 nodes (sites) for the MPE data and about 300,000 nodes (sites) for the Hydro-NEXRAD product. Automated harvesting services have been implemented for both data products. The MPE data is harvested from its download site using ArcGIS which in turn is used to extract the data for the Chesapeake Bay watershed before a scripting program is used to scatter the data into the ODM. The Hydro-NEXRAD is downloaded from a web-based system at the University of Iowa which permits downloads for large scale watersheds organized by Hydraulic Unit Codes (HUC). The resulting ASCII is then automatically parsed and the information stored alongside the MPE data. The two data products stored side-by-side then allows a comparison between them addressing the accuracy and agreement between the methods used to arrive at rainfall data as both use the raw reflectivity data from the WSD-88D system.

  9. Bekæmpelse af rynket rose II

    DEFF Research Database (Denmark)

    Buttenschøn, Rita M.; Ransijn, Johannes

    2014-01-01

    Rynket rose er en invasiv art, der har spredt sig voldsomt gennem de seneste år – ikke kun i Danmark men i hele Europa. Den er svær at bekæmpe, og derfor har Naturstyrelsen Thy og Thisted Kommune i perioden 2010-2013 gennemført en række kontrollerede forsøg med slåning, græsning og kemisk...... bekæmpelse af rynket rose....

  10. Achieving Better Buying Power through Acquisition of Open Architecture Software Systems for Web and Mobile Devices

    Science.gov (United States)

    2016-02-22

    user query, a database management system, (like MySQL or Oracle 11) that stores, queries and updates metadata associated with the requested content...5.2 Common technology (e.g., Ozone widget framework, Java ); and 5.3 Shared infrastructure (Joint Information Environment, MPE, ICITE). 5.4 Data...or may not be subject to proprietary IP licenses or “fair use” doctrine (cf. Oracle v. Google, re: Java APIs, now pending before the SCOTUS): 15.1 Use

  11. Phycoerythrin-specific bilin lyase-isomerase controls blue-green chromatic acclimation in marine Synechococcus.

    Science.gov (United States)

    Shukla, Animesh; Biswas, Avijit; Blot, Nicolas; Partensky, Frédéric; Karty, Jonathan A; Hammad, Loubna A; Garczarek, Laurence; Gutu, Andrian; Schluchter, Wendy M; Kehoe, David M

    2012-12-04

    The marine cyanobacterium Synechococcus is the second most abundant phytoplanktonic organism in the world's oceans. The ubiquity of this genus is in large part due to its use of a diverse set of photosynthetic light-harvesting pigments called phycobiliproteins, which allow it to efficiently exploit a wide range of light colors. Here we uncover a pivotal molecular mechanism underpinning a widespread response among marine Synechococcus cells known as "type IV chromatic acclimation" (CA4). During this process, the pigmentation of the two main phycobiliproteins of this organism, phycoerythrins I and II, is reversibly modified to match changes in the ambient light color so as to maximize photon capture for photosynthesis. CA4 involves the replacement of three molecules of the green light-absorbing chromophore phycoerythrobilin with an equivalent number of the blue light-absorbing chromophore phycourobilin when cells are shifted from green to blue light, and the reverse after a shift from blue to green light. We have identified and characterized MpeZ, an enzyme critical for CA4 in marine Synechococcus. MpeZ attaches phycoerythrobilin to cysteine-83 of the α-subunit of phycoerythrin II and isomerizes it to phycourobilin. mpeZ RNA is six times more abundant in blue light, suggesting that its proper regulation is critical for CA4. Furthermore, mpeZ mutants fail to normally acclimate in blue light. These findings provide insights into the molecular mechanisms controlling an ecologically important photosynthetic process and identify a unique class of phycoerythrin lyase/isomerases, which will further expand the already widespread use of phycoerythrin in biotechnology and cell biology applications.

  12. Cooperative Control of Active Power Filters in Power Systems without Mutual Communication

    Czech Academy of Sciences Publication Activity Database

    Tlustý, J.; Škramlík, Jiří; Švec, J.; Valouch, Viktor

    2010-01-01

    Roč. 2010, č. 517184 (2010), s. 1-13 ISSN 1024-123X R&D Projects: GA AV ČR IAA200760703 Institutional research plan: CEZ:AV0Z20570509 Keywords : active power filter * power system * wireless cooperation Subject RIV: JA - Electronics ; Optoelectronics, Electric al Engineering Impact factor: 0.689, year: 2010 http://www.hindawi.com/journals/mpe/2010/517184.html

  13. A Conceptual Development of Quench Prediction App build on LSTM and ELQA framework

    OpenAIRE

    Mertik, Matej; Wielgosz, Maciej; Skoczeń, Andrzej

    2016-01-01

    This article presents a development of web application for quench prediction in \\gls{te-mpe-ee} at CERN. The authors describe an ELectrical Quality Assurance (ELQA) framework, a platform which was designed for rapid development of web integrated data analysis applications for different analysis needed during the hardware commissioning of the Large Hadron Collider (LHC). In second part the article describes a research carried out with the data collected from Quench Detection System by means of...

  14. OPTIMUM: a protocol for a multicentre randomised controlled trial comparing Out Patient Talc slurry via Indwelling pleural catheter for Malignant pleural effusion vs Usual inpatient Management.

    Science.gov (United States)

    Sivakumar, P; Douiri, A; West, A; Rao, D; Warwick, G; Chen, T; Ahmed, L

    2016-10-18

    The development of malignant pleural effusion (MPE) results in disabling breathlessness, pain and reduced physical capability with treatment a palliative strategy. Ambulatory management of MPE has the potential to improve quality of life (QoL). The OPTIMUM trial is designed to determine whether full outpatient management of MPE with an indwelling pleural catheter (IPC) and pleurodesis improves QoL compared with traditional inpatient care with a chest drain and talc pleurodesis. OPTIMUM is currently open for any centres interested in collaborating in this study. OPTIMUM is a multicentre non-blinded randomised controlled trial. Patients with a diagnosis of MPE will be identified and screened for eligibility. Consenting participants will be randomised 1:1 either to an outpatient ambulatory pathway using IPCs and talc pleurodesis or standard inpatient treatment with chest drain and talc pleurodesis as per British Thoracic Society guidelines. The primary outcome measure is global health-related QoL at 30 days measured using the EORTC QLQ-C30 questionnaire. Secondary outcome measures include breathlessness and pain measured using a 100 mm Visual Analogue Scale and health-related QoL at 60 and 90 days. A sample size of 142 patients is needed to demonstrate a clinically significant difference of 8 points in global health status at 30 days, for an 80% power and a 5% significance level. The study has been approved by the NRES Committee South East Coast-Brighton and Sussex (reference 15/LO/1018). The trial results will be published in peer-reviewed journals and presented at scientific conferences. UKCRN19615 and ISRCTN15503522; Pre-results. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  15. Morphologic characteristics of central pulmonary thromboemboli predict haemodynamic response in massive pulmonary embolism.

    Science.gov (United States)

    Podbregar, Matej; Voga, Gorazd; Krivec, Bojan

    2004-08-01

    On hospital admission, the morphology of the central pulmonary artery thromboemboli is an independent predictor of 30-day mortality in patients with massive pulmonary embolism (MPE). This may be due to the differential susceptibility of thromboemboli to thrombolysis. The aim of this study was to assess haemodynamic response to treatment in patients with MPE and morphologically different thromboemboli. Prospective observational study. An 11-bed closed medical ICU at a 860-bed community general hospital. Twelve consecutive patients with shock or hypotension due to MPE and central pulmonary thromboemboli detected by transesophageal echocardiography who were treated with thrombolysis between January 2000 through April 2002. Patients were divided into two groups according to the characteristics of detected central pulmonary thromboemboli: group 1, thrombi with one or more long, mobile parts; and group 2, immobile thrombi. Urokinase infusion was terminated when mixed venous oxygen saturation was stabilized above 60% for 15 min. At 2 h, the total pulmonary vascular resistance index was reduced more in group 1 than group 2 [from 27+/-12 mmHg/(l.min.m(2)) to 14+/-6 mmHg/(l.min.m(2)) (-52%) vs 27+/-8 mmHg/(l.min.m(2)) to 23+/-10 mmHg/(l.min.m(2)) (-15%), respectively, P=0.04]. In group 1 thrombolysis was terminated earlier than group 2 (89+/-40 min vs 210+/-62 min, respectively, P= 0.0024). The cumulative dose of urokinase used in group 1 was lower than group 2 (1.7+/-0.3 M i.u. vs 2.7+/-0.5 M i.u., respectively, P= 0.023). Haemodynamic stabilization is achieved faster in patients with mobile central thromboemboli detected by transesophageal echocardiography during MPE.

  16. 249-IJBCS-Article-Dr Adomou Aristide

    African Journals Online (AJOL)

    Dr Gatsing

    MPE and Traoré D (eds). CAB. International: UK and Cambridge; 19-39. INSAE 2002. Troisième recensement général de la population et de l'habitat. Résultats définitifs: Tableaux statistiques Cotonou,. Bénin, 4p. Lebrun J, Gilbert G. 1954. Une classification écologique des forêts du Congo. Publ. I.N.E.A.C., sér. Sc., 63: 89.

  17. An Ecohydrological Approach to Managing Intermittent and Ephemeral Streams on Department of Defense Lands in the Southwestern United States

    Science.gov (United States)

    2015-01-30

    USDA: United States Department of Agriculture, http://www.usda.gov USLE : Universal Soil Loss Equation, http://topsoil.nserl.purdue.edu/ usle / ix...Modified Soil Adjusted Vegetation Index (Qi et al., 1994) NCDC: National Climatic Data Center NDVI: Normalized Difference Vegetation Index NEXRAD-MPE...www.rapideye.net/ RENDVI: Red Edge Normalized Difference Vegetation Index RS: Remote sensing RSI: Rainfall Seasonality Index SAVI: Soil Adjusted Vegetation

  18. Ventilation i industrien

    DEFF Research Database (Denmark)

    Valbjørn, O.

    I en række afsnit belyses problemer med træk, kulde, varme, og luftforurening på industriens arbejdspladser, og hvordan man ved ventilation og bygningsudformning kan bekæmpe disse gener. Hvert afsnit kan i princippet læses for sig, og anvisningen kan derfor bruges som håndbog, både af de der er...

  19. Operation of the power system 2011; Driften av kraftsystemet 2011

    Energy Technology Data Exchange (ETDEWEB)

    Brekke, Karstein; Ulsberg, Helge

    2012-07-01

    This report has been prepared as a result of the allotment letters for 2012 to the Norwegian Water Resources and Energy Directorate (NVE) of Petroleum and Energy (MPE), which imposes NVE to prepare an annual report on the operation of the power system. The report shall include information and analysis related to the state of the power system, including errors in key transmission links within Norway and abroad. (Author)

  20. Hyperstress

    DEFF Research Database (Denmark)

    Baldursson, Einar Baldvin

    Stress er et stort problem i vores moderne hverdag med det moderne arbejdsliv, der konstant kræver omstillingsparathed. Alligevel forsøger vi at finde 'gamle' og traditionelle løsninger på, hvordan vi skal bekæmpe stress. Denne bog forslår i stedet, at vi finder en ny, fremadrettet forståelse af,...

  1. Activity of antimicrobial peptide mimetics in the oral cavity: II. Activity against periopathogenic biofilms and anti-inflammatory activity

    Science.gov (United States)

    Hua, J; Scott, R.W.; Diamond, G

    2011-01-01

    Whereas periodontal disease is ultimately of bacterial etiology, from multispecies biofilms of gram-negative anaerobic microorganisms, much of the deleterious effects are caused by the resultant epithelial inflammatory response. Hence, development of a treatment that combines anti-biofilm antibiotic activity with anti-inflammatory activity would be of great utility. Antimicrobial peptides (AMPs) such as defensins are naturally occurring peptides that exhibit broad-spectrum activity as well as a variety of immunomodulatory activities. Furthermore, bacteria do not readily develop resistance to these agents. However, clinical studies have suggested that they do not represent optimal candidates for exogenous therapeutic agents. Small-molecule mimetics of these AMPs exhibit similar activities to the parent peptides, in addition to having low toxicity, high stability and low cost. To determine whether AMP mimetics have the potential for treatment of periodontal disease, we examined the activity of one mimetic, mPE, against biofilm cultures of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. Metabolic assays as well as culture and biomass measurement assays demonstrated that mPE exhibits potent activity against biofilm cultures of both species. Furthermore, as little as 2 µg ml−1 mPE was sufficient to inhibit interleukin-1β-induced secretion of interleukin-8 in both gingival epithelial cells and THP-1 cells. This anti-inflammatory activity is associated with a reduction in activation of nuclear factor-κB, suggesting that mPE can act both as an anti-biofilm agent in an anaerobic environment and as an anti-inflammatory agent in infected tissues. PMID:21040516

  2. Does Marriage Make Us Healthier? Inter-Country Comparative Evidence from China, Japan, and Korea.

    Science.gov (United States)

    Fu, Rong; Noguchi, Haruko

    2016-01-01

    This study focuses on East Asian countries and investigates the difference in the marriage premium on the health-marriage protection effect (MPE) between younger and older generations and the intra-couple education concordance effect (ECE) on the health of married individuals. This study used inter-country comparative data from China, Japan, and Korea. This study focused on individuals (n = 7,938) in China, Japan, and Korea who were sampled from the 2010 East Asian Social Survey. To investigate MPE and ECE, four health indicators were utilized: a physical and mental components summary (PCS and MCS), self-rated health status (Dself), and happiness level (Dhappy). Ordinary least squares regression was conducted by country- and gender-specific subsamples. We found that the MPE on PCS, MCS, and Dself was more significant for the older generation than for the younger generation in both China and Japan, whereas the results were inconclusive in Korea. With regard to the ECE on happiness (Dhappy), for both men and women, couples tend to be happier when both the husband and the wife are well educated ("higher balanced marriage") compared to couples with a lower level of educational achievement ("lower balanced marriage"). Significant benefits from a "higher balanced marriage" on MCS and Dself were observed for women only. In contrast, no statistically significant differences in health status were observed between "higher balanced marriage" couples and couples with different levels of educational achievements ("upward marriage" or "downward marriage"). This study found that (1) the MPE was more significant for the older generation, and (2) the health gap, particularly the happiness gap, between higher- and lower-balanced married couples was significant. The inter-country comparative findings are useful to explain how the role of marriage (and therefore of family) on health has been diluted due to the progress of industrialization and modernization.

  3. Integration of Molecular Pathology, Epidemiology, and Social Science for Global Precision Medicine

    Science.gov (United States)

    Nishi, Akihiro; Milner, Danny A; Giovannucci, Edward L.; Nishihara, Reiko; Tan, Andy S.; Kawachi, Ichiro; Ogino, Shuji

    2015-01-01

    Summary The precision medicine concept and the unique disease principle imply that each patient has unique pathogenic processes resulting from heterogeneous cellular genetic and epigenetic alterations, and interactions between cells (including immune cells) and exposures, including dietary, environmental, microbial, and lifestyle factors. As a core method field in population health science and medicine, epidemiology is a growing scientific discipline that can analyze disease risk factors, and develop statistical methodologies to maximize utilization of big data on populations and disease pathology. The evolving transdisciplinary field of molecular pathological epidemiology (MPE) can advance biomedical and health research by linking exposures to molecular pathologic signatures, enhancing causal inference, and identifying potential biomarkers for clinical impact. The MPE approach can be applied to any diseases, although it has been most commonly used in neoplastic diseases (including breast, lung and colorectal cancers) because of availability of various molecular diagnostic tests. However, use of state-of-the-art genomic, epigenomic and other omic technologies and expensive drugs in modern healthcare systems increases racial, ethnic and socioeconomic disparities. To address this, we propose to integrate molecular pathology, epidemiology, and social science. Social epidemiology integrates the latter two fields. The integrative social MPE model can embrace sociology, economics and precision medicine, address global health disparities and inequalities, and elucidate biological effects of social environments, behaviors, and networks. We foresee advancements of molecular medicine, including molecular diagnostics, biomedical imaging, and targeted therapeutics, which should benefit individuals in a global population, by means of an interdisciplinary approach of integrative MPE and social health science. PMID:26636627

  4. Predictive Factors and Treatment Outcomes of Tuberculous Pleural Effusion in Patients With Cancer and Pleural Effusion.

    Science.gov (United States)

    Lee, Jaehee; Lee, Yong Dae; Lim, Jae Kwang; Lee, Deok Heon; Yoo, Seung Soo; Lee, Shin Yup; Cha, Seung Ick; Park, Jae Yong; Kim, Chang Ho

    2017-08-01

    Patients with cancer are at an increased risk of tuberculosis. As pleural effusion has great clinical significance in patients with cancer, the differential diagnosis between tuberculous pleural effusion (TPE) and malignant pleural effusion (MPE) is important. However, the predictive factors and treatment outcomes of TPE in patients with cancer have rarely been studied. Confirmed TPE cases identified at cancer diagnosis and during anticancer management from 2008-2015 were retrospectively investigated. Patients in the study included coexisting TPE and cancer (n = 20), MPE (n = 40) and TPE without cancer (n = 40). Control groups were patients with MPE, and patients with TPE without cancer. Clinical, laboratory and pleural fluid characteristics were compared among groups. Treatment outcomes were compared between patients with TPE with and without cancer. In the final analysis, serum C-reactive protein (S-CRP) ≥3.0mg/dL and pleural fluid adenosine deaminase (ADA) ≥40U/L were independent predictors for identifying TPE in patients with cancer having pleural effusion. The combination of S-CRP with pleural fluid ADA using an "or" rule achieved a sensitivity of 100%, whereas both parameters combined in an "and" rule had a specificity of 98%. Treatment outcomes were not different between the TPE groups with and without cancer. S-CRP and pleural fluid ADA levels may be helpful for predicting TPE in patients with cancer with pleural effusion. The combination of these biomarkers provides better information for distinguishing between TPE and MPE in these patients. Treatment outcomes of TPE in patients with cancer are comparable to those in patients without cancer. Copyright © 2017 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

  5. Massive pulmonary embolism: the predisposing and complicating factors, its current diagnostic approaches and critical importance of early diagnostic physical exam

    Directory of Open Access Journals (Sweden)

    Filip A. Konecny

    2006-12-01

    Full Text Available Massive pulmonary embolism (MPE often leads to circulation collapse, a form of shock. The process is set off by thrombus or multiple thrombi dislodgement followed by a rapid perfusion insufficiency of pulmonary arterial system. Patients experience severe hypotension with diastolic and systolic failure with an acute tricuspid regurgitation. On many occasions, release of an obstruction is unattainable and death is occurring frequently within one hour of presentation. A key reported source of MPE is its occurrence as a complication of deep vein thrombosis (DVT. While long-term immobilization and surgery are both directly associated with MPE, others such as previous DVT, malignancy, infectious lung and heart diseases, family thrombophilia, lower limb paralysis and pregnancy have to be considered as risk factors mainly due to its silent nature. Predisposing and complicating risks should be addressed by an early diagnostic physical exam. The clinician might offer a wide variety of diagnostic approaches, combining techniques into algorithms to better deal with the embolism severity. Multiple patient life-style changes and decisions to adhere to the proposed plan should be built up on patient-physician team effort. KEY WORDS: Massive pulmonary embolism, predisposing factors, current diagnostic approaches.

  6. A moment-convergence method for stochastic analysis of biochemical reaction networks.

    Science.gov (United States)

    Zhang, Jiajun; Nie, Qing; Zhou, Tianshou

    2016-05-21

    Traditional moment-closure methods need to assume that high-order cumulants of a probability distribution approximate to zero. However, this strong assumption is not satisfied for many biochemical reaction networks. Here, we introduce convergent moments (defined in mathematics as the coefficients in the Taylor expansion of the probability-generating function at some point) to overcome this drawback of the moment-closure methods. As such, we develop a new analysis method for stochastic chemical kinetics. This method provides an accurate approximation for the master probability equation (MPE). In particular, the connection between low-order convergent moments and rate constants can be more easily derived in terms of explicit and analytical forms, allowing insights that would be difficult to obtain through direct simulation or manipulation of the MPE. In addition, it provides an accurate and efficient way to compute steady-state or transient probability distribution, avoiding the algorithmic difficulty associated with stiffness of the MPE due to large differences in sizes of rate constants. Applications of the method to several systems reveal nontrivial stochastic mechanisms of gene expression dynamics, e.g., intrinsic fluctuations can induce transient bimodality and amplify transient signals, and slow switching between promoter states can increase fluctuations in spatially heterogeneous signals. The overall approach has broad applications in modeling, analysis, and computation of complex biochemical networks with intrinsic noise.

  7. Effect of dietary ethanol extracts of mango (Mangifera indica L.) on lipid oxidation and the color of chicken meat during frozen storage.

    Science.gov (United States)

    Freitas, Ednardo Rodrigues; da Silva Borges, Ângela; Pereira, Ana Lúcia Fernandes; Abreu, Virgínia Kelly Gonçalves; Trevisan, Maria Teresa Salles; Watanabe, Pedro Henrique

    2015-12-01

    The aim of this study was to evaluate the dietary effect of mango extracts on lipid stability and the coloring of broiler chicken breast meat during frozen storage. The treatments consisted of broiler chicken diet without antioxidants (control) and diets containing antioxidants: 200 ppm of butylated hydroxytoluene (BHT), 200 ppm of mango peel extract (MPE), 400 ppm of MPE, 200 ppm of mango seed extract (MSE), and 400 ppm of MSE. The broiler breasts were stored for 90 days and analysis of lipid oxidation and color was performed every 30 days. The thiobarbituric acid reactive substances values increased during storage and at 90 days, but the 400 ppm MSE treatment yielded lower values, indicating greater antioxidant activity. During storage, the lightness values decreased and the redness increased. Additions of 200 ppm BHT and 400 ppm MPE increased yellowness at 60 days of storage. Thus, mango peel and seed extracts added to broiler chicken diets reduce lipid oxidation and maintain color in breast meat during frozen storage, with mango seed extract at 400 ppm being the most effective. © 2015 Poultry Science Association Inc.

  8. Initialization and Restart in Stochastic Local Search: Computing a Most Probable Explanation in Bayesian Networks

    Science.gov (United States)

    Mengshoel, Ole J.; Wilkins, David C.; Roth, Dan

    2010-01-01

    For hard computational problems, stochastic local search has proven to be a competitive approach to finding optimal or approximately optimal problem solutions. Two key research questions for stochastic local search algorithms are: Which algorithms are effective for initialization? When should the search process be restarted? In the present work we investigate these research questions in the context of approximate computation of most probable explanations (MPEs) in Bayesian networks (BNs). We introduce a novel approach, based on the Viterbi algorithm, to explanation initialization in BNs. While the Viterbi algorithm works on sequences and trees, our approach works on BNs with arbitrary topologies. We also give a novel formalization of stochastic local search, with focus on initialization and restart, using probability theory and mixture models. Experimentally, we apply our methods to the problem of MPE computation, using a stochastic local search algorithm known as Stochastic Greedy Search. By carefully optimizing both initialization and restart, we reduce the MPE search time for application BNs by several orders of magnitude compared to using uniform at random initialization without restart. On several BNs from applications, the performance of Stochastic Greedy Search is competitive with clique tree clustering, a state-of-the-art exact algorithm used for MPE computation in BNs.

  9. Summer student final report

    CERN Document Server

    Guzik, Jakub

    2013-01-01

    During my time spent at CERN I worked under the Technology Department of CERN, in the Machine Protection and Electrical Integrity (MPE) Group. The MPE Group supports LHC operations and maintains state of the art technology for magnet circuit protection and interlock systems for the present and future accelerators, magnet test facilities and CERN hosted experiments[1]. As a member of Magnet Powering Interlocks & Software (TE-MPE-MS) section I was involved in three different projects and used not only CERN developed tools like FESA Framework, but also open source C++ frameworks, Google Test and Google Mock. I had a chance to work with Programmable Logic Controllers and real-time devices known as Front End Computers. I was part of a software developer team, and familiarized myself with the Scrum agile software development methodology. The description and results of my work are presented in three parts of this report. Each part describes a separate project created during my participation in the CERN Summer St...

  10. Development and validation of an LC-MS/MS method for simultaneous quantification of levodopa and MD01 in rat plasma and its application to a pharmacokinetic study of mucuna pruriens extract.

    Science.gov (United States)

    Yang, Guangjie; Zhang, Fangrong; Deng, Linfang; Chen, Chang; Cheng, Zhongzhe; Huang, Jiangeng; Liu, Jiangyun; Jiang, Hongliang

    2016-09-01

    Mucuna pruriens, an ancient Indian herbal medicine containing levodopa, is widely used for Parkinson's disease. In order to simultaneously determine levodopa and 1,1-dimethyl-3-carboxy-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (MD01) in rat plasma, an improved LC-MS/MS method was developed and validated for a pharmacokinetic study in rats orally administered levodopa or Mucuna pruriens extract (MPE). Elimination of matrix effect and improvement of extraction recovery were achieved through systematic optimization of reversed-phase and hydrophilic interaction chromatographic conditions together with sample clean-up procedures. A satisfactory chromatographic performance was obtained with a Thermo Aquasil C18 column (50 × 2.1 mm, 3 µm) using acetonitrile and water containing 0.2% formic acid as mobile phases. Futhermore, sodium metabisulfite and formic acid were used as stabilizers in neat solutions as well as rat plasma. The method was validated in a dynamic range of 20.0-10,000 ng/mL for levodopa and MD01; the intra- and inter-day precision and accuracy were acceptable. The method was successfully utilized to determine the levodopa level in plasma samples of rats administered levodopa or MPE. Pharmacokinetic results showed that an increase in the AUC of levodopa was observed in rats following oral administration of multiple doses of MPE. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  11. Intrapleural chemo- and hyperthermotherapies for malignant pleural effusion: a randomized prospective study.

    Science.gov (United States)

    Chen, Wen-Jun; Yuan, Shao-Fei; Yan, Qing-Yuan; Xiong, Jian-Ping; Wang, Sen-Ming; Zheng, Wei-E; Zhang, Wu; Sun, Hong-Yu; Chen, Hua; Wu, Li-Li

    2012-02-01

    The current prospective randomized study was designed to evaluate the safety and efficacy of combined intrapleural cisplatin and OK-432 (picibanil) plus hyperthermotherapy in patients with malignant pleural effusion (MPE). A total of 358 patients with MPE due to end-stage malignancies were enrolled and randomly divided into two groups, A and B: the intrapleural combination of cisplatin and OK-432 with hyperthermotherapy (n = 179) or without hyperthermotherapy (n = 179), respectively. Mild toxicities such as nausea, vomiting or anorexia, bone marrow depression, and pyrexia were similar in both groups. Patients in Group A (with hyperthermotherapy) showed a significantly higher overall response (93.4%) compared to those in Group B (79.8%, χ(2) = 43.11, p .05). After treatment, the quality of life scores were significantly increased in both groups as compared to prior treatment (p < .05). In conclusion, our study suggests that combined intrapleural cisplatin and OK-432 followed by hyperthermotherapy are more effective in the control of MPE and improve patients' quality of life.

  12. Diagnosis and treatment of shock due to massive pulmonary embolism: approach with transesophageal echocardiography and intrapulmonary thrombolysis.

    Science.gov (United States)

    Krivec, B; Voga, G; Zuran, I; Skale, R; Pareznik, R; Podbregar, M; Noc, M

    1997-11-05

    To evaluate the diagnostic value of transesophageal echocardiography (TEE) as an initial diagnostic tool in shocked patients. The second objective was to study therapeutic impact of intrapulmonary thrombolysis in patients with diagnosed massive pulmonary embolism. Prospective observational study. Medical ICU in 800-bed general hospital. Twenty-four consecutive patients with unexplained shock and distended jugular veins. In 18 patients, right ventricular dilatation with global or segmental hypokinesis was documented. In addition, central pulmonary thromboemboli (12 patients), reduced contrast flow in right pulmonary artery (one patient), and right ventricular free wall akinesis (one patient) were found. No additional echocardiographic findings were apparent in four patients. According to pulmonary scintigraphy or autopsy, sensitivity of TEE for diagnosis of massive pulmonary embolism (MPE) in patients with right ventricular dilatation was 92% and specificity was 100%. In patients without right ventricular dilatation, left ventricular dysfunction (four patients) or cardiac tamponade (two patients) was confirmed. Intrapulmonary thrombolysis was evaluated in 11 of 13 patients with MPE. Two patients died prior to attempted thrombolysis. Three patients received streptokinase and eight received urokinase. Twenty-four hours after beginning of treatment, total pulmonary resistance index significantly decreased for 59% and mean pulmonary artery pressure for 31%. Cardiac index increased for 74%. Nine of 11 patients receiving thrombolysis survived to hospital discharge. Bedside TEE is a valuable tool for diagnosis of MPE. It enables immediate intrapulmonary thrombolysis, which seems to be an effective therapeutic alternative in our group of patients with obstructive shock.

  13. Standard and Nonstandard Craniospinal Radiotherapy Using Helical TomoTherapy

    International Nuclear Information System (INIS)

    Parker, William; Brodeur, Marylene; Roberge, David; Freeman, Carolyn

    2010-01-01

    Purpose: To show the advantages of planning and delivering craniospinal radiotherapy with helical TomoTherapy (TomoTherapy Inc., Madison, WI) by presenting 4 cases treated at our institution. Methods and Materials: We first present a standard case of craniospinal irradiation in a patient with recurrent myxopapillary ependymoma (MPE) and follow this with 2 cases requiring differential dosing to multiple target volumes. One of these, a patient with recurrent medulloblastoma, required a lower dose to be delivered to the posterior fossa because the patient had been previously irradiated to the full dose, and the other required concurrent boosts to leptomeningeal metastases as part of his treatment for newly diagnosed MPE. The final case presented is a patient with pronounced scoliosis who required spinal irradiation for recurrent MPE. Results: The four cases presented were planned and treated successfully with Helical Tomotherapy. Conclusions: Helical TomoTherapy delivers continuous arc-based intensity-modulated radiotherapy that gives high conformality and excellent dose homogeneity for the target volumes. Increased healthy tissue sparing is achieved at higher doses albeit at the expense of larger volumes of tissue receiving lower doses. Helical TomoTherapy allows for differential dosing of multiple targets, resulting in very elegant dose distributions. Daily megavoltage computed tomography imaging allows for precision of patient positioning, permitting a reduction in planning margins and increased healthy tissue sparing in comparison with standard techniques.

  14. Multiscale Permutation Entropy Based Rolling Bearing Fault Diagnosis

    Directory of Open Access Journals (Sweden)

    Jinde Zheng

    2014-01-01

    Full Text Available A new rolling bearing fault diagnosis approach based on multiscale permutation entropy (MPE, Laplacian score (LS, and support vector machines (SVMs is proposed in this paper. Permutation entropy (PE was recently proposed and defined to measure the randomicity and detect dynamical changes of time series. However, for the complexity of mechanical systems, the randomicity and dynamic changes of the vibration signal will exist in different scales. Thus, the definition of MPE is introduced and employed to extract the nonlinear fault characteristics from the bearing vibration signal in different scales. Besides, the SVM is utilized to accomplish the fault feature classification to fulfill diagnostic procedure automatically. Meanwhile, in order to avoid a high dimension of features, the Laplacian score (LS is used to refine the feature vector by ranking the features according to their importance and correlations with the main fault information. Finally, the rolling bearing fault diagnosis method based on MPE, LS, and SVM is proposed and applied to the experimental data. The experimental data analysis results indicate that the proposed method could identify the fault categories effectively.

  15. A moment-convergence method for stochastic analysis of biochemical reaction networks

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Jiajun [School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275 (China); Nie, Qing [Department of Mathematics, University of California at Irvine, Irvine, California 92697 (United States); Zhou, Tianshou, E-mail: mcszhtsh@mail.sysu.edu.cn [School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275 (China); Guangdong Province Key Laboratory of Computational Science and School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275 (China)

    2016-05-21

    Traditional moment-closure methods need to assume that high-order cumulants of a probability distribution approximate to zero. However, this strong assumption is not satisfied for many biochemical reaction networks. Here, we introduce convergent moments (defined in mathematics as the coefficients in the Taylor expansion of the probability-generating function at some point) to overcome this drawback of the moment-closure methods. As such, we develop a new analysis method for stochastic chemical kinetics. This method provides an accurate approximation for the master probability equation (MPE). In particular, the connection between low-order convergent moments and rate constants can be more easily derived in terms of explicit and analytical forms, allowing insights that would be difficult to obtain through direct simulation or manipulation of the MPE. In addition, it provides an accurate and efficient way to compute steady-state or transient probability distribution, avoiding the algorithmic difficulty associated with stiffness of the MPE due to large differences in sizes of rate constants. Applications of the method to several systems reveal nontrivial stochastic mechanisms of gene expression dynamics, e.g., intrinsic fluctuations can induce transient bimodality and amplify transient signals, and slow switching between promoter states can increase fluctuations in spatially heterogeneous signals. The overall approach has broad applications in modeling, analysis, and computation of complex biochemical networks with intrinsic noise.

  16. [Clinical Value of Cell Block in the Diagnosis of Malignant Pleural Effusion].

    Science.gov (United States)

    Wang, Xintong; Cheng, Fangyuan; Zhong, Diansheng; Zhang, Lisha; Meng, Fanlu; Shao, Yi; Yu, Tao

    2017-06-20

    Malignant pleural effusion (MPE) is due tumor which arises from the mesothelium or metastases from tumor origniating other sites. Generally, the prognosis of MPE is poor, in the premise of reducing the pain of patients, as soon as possible make clear the property of pleural effusion and cause of the disesease, rightly and quickly, providing effective information for subsequent treatment. The cell block of 103 patients by using natural sedimentation or plasma coagulation method combined with HE staining and immunohistochemical staining method maked clear diagnosis and compared with other methods. 90 patients were diagnosed by cell block section from 103 patients who had MPE (diagnostic rate 87.4%); 32 cases were diagnosed by cell block section only, 74 cases pointed out that the pathological type , 23 cases even pointed out the primary lesions; 71 cases examined other invasive methods at the same time, the diagnostic rate was 87.3% and 81.7%; the detection rate of cell block section and cytological smear in detecting malignant tumor cells was 86.7%and 44.0% respectively. Cell block can not only increase the diagnosis, in contrast to cytological smear, and own the same diagnostic rate compared with other invasive methods, but also can confirm pathological type and primary lesion; especially, for other invasive methods, cell block method is a preferable complementary method, and that cell block method maybe the only way for some patients.

  17. Prognostic factors in patients with malignant pleural effusion: Is it possible to predict mortality in patients with good performance status?

    Science.gov (United States)

    Abrao, Fernando Conrado; Peixoto, Renata D'Alpino; de Abreu, Igor Renato Louro Bruno; Janini, Maria Cláudia; Viana, Geisa Garcia; de Oliveira, Mariana Campello; Younes, Riad Naim

    2016-04-01

    The aim of this study was to identify predictors of mortality only in patients with malignant pleural effusion (MPE) showing good performance status which required pleural palliative procedures. All patients with MPE submitted to pleural palliative procedure were enrolled in a prospective study between 2013 and 2014. Patients with Eastern cooperative oncology group (ECOG) score zero, one, and two were considered with good performance status. The possible prognostic factors were tested for significance using the log-rank test (Kaplan-Meier method) and those with significance on univariate analysis were entered into a multivariable Cox model. A total of 64 patients were included in the analysis. Median follow-up time for surviving patients was 263 days. Median survival for the entire cohort was not reached yet. In the multivariate analysis, gastrointestinal primary site (P = 0.006), low albumin concentration in the pleural fluid (P = 0.017), and high serum NLR (P = 0.007) were associated with mortality. In our cohort of ECOG 0-2 patients with MPE submitted to pleural palliative procedures, gastrointestinal malignancy compared to other sites, low pleural fluid albumin and high NLR were significantly associated with mortality. The identification of these prognostic factors may assist the choice of the optimal palliative technique. J. Surg. Oncol. 2016;113:570-574. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  18. Association of HLA-A and HLA-B Alleles with Lamotrigine-Induced Cutaneous Adverse Drug Reactions in the Thai Population

    Directory of Open Access Journals (Sweden)

    Napatrupron Koomdee

    2017-11-01

    Full Text Available Background: Lamotrigine (LTG is commonly used for treatment of epilepsy and bipolar disorder. It is one of the common cause of cutaneous adverse drug reactions (CADR. Clinical symptoms of LTG-induced CADR range from maculopapular exanthema (MPE to severe cutaneous adverse reactions (SCAR. This study aimed to determine the association of the LTG-induced CADR with human leukocyte antigen (HLA alleles in Thai patients.Methods: Fifteen patients with LTG-induced CADR [10 MPE; 4 Stevens–Johnson syndrome; and 1 drug reaction with eosinophilia and systemic symptoms] and 50 LTG-tolerant controls were included in the study. HLA-A and HLA-B genotyping was performed using polymerase chain reaction-sequence-specific oligonucleotides probes.Results: The proportion of HLA-A∗02:07 and HLA-B∗15:02 allele carriers were significantly higher in the LTG-induced CADR group than in the tolerant controls [odds ratio (OR: 7.83; 95% confidence interval (CI: 1.60–38.25; P = 0.013, and OR: 4.89; 95% CI: 1.28–18.67; P = 0.014]. In addition, subjects with HLA-A∗33:03, HLA-B∗15:02, and HLA-B∗44:03 were significantly higher in the LTG-induced MPE group than in the tolerant controls (OR: 8.27; 95% CI: 1.83–37.41; P = 0.005, OR: 7.33; 95% CI: 1.63–33.02; P = 0.005; and OR: 10.29; 95% CI: 1.45–72.81; P = 0.029. In contrast to the LTG-induced MPE group, there were no significant differences between HLA alleles and LTG-induced SCAR group.Conclusion:HLA-A∗02:07 and HLA-B∗15:02 were associated with LTG-induced CADR in Thai patients. We also identified an association between HLA-A∗33:03, HLA-B∗15:02, and HLA-B∗44:03 and LTG-induced MPE in this population. These results suggest that these alleles could be useful screening markers for preventing CADR before LTG treatment in Thai patients, but further replication studies with larger sample sizes are needed.

  19. Evaluating the MSG satellite Multi-Sensor Precipitation Estimate for extreme rainfall monitoring over northern Tunisia

    Directory of Open Access Journals (Sweden)

    Saoussen Dhib

    2017-06-01

    Full Text Available Knowledge and evaluation of extreme precipitation is important for water resources and flood risk management, soil and land degradation, and other environmental issues. Due to the high potential threat to local infrastructure, such as buildings, roads and power supplies, heavy precipitation can have an important social and economic impact on society. At present, satellite derived precipitation estimates are becoming more readily available. This paper aims to investigate the potential use of the Meteosat Second Generation (MSG Multi-Sensor Precipitation Estimate (MPE for extreme rainfall assessment in Tunisia. The MSGMPE data combine microwave rain rate estimations with SEVIRI thermal infrared channel data, using an EUMETSAT production chain in near real time mode. The MPE data can therefore be used in a now-casting mode, and are potentially useful for extreme weather early warning and monitoring. Daily precipitation observed across an in situ gauge network in the north of Tunisia were used during the period 2007–2009 for validation of the MPE extreme event data. As a first test of the MSGMPE product's performance, very light to moderate rainfall classes, occurring between January and October 2007, were evaluated. Extreme rainfall events were then selected, using a threshold criterion for large rainfall depth (>50 mm/day occurring at least at one ground station. Spatial interpolation methods were applied to generate rainfall maps for the drier summer season (from May to October and the wet winter season (from November to April. Interpolated gauge rainfall maps were then compared to MSGMPE data available from the EUMETSAT UMARF archive or from the GEONETCast direct dissemination system. The summation of the MPE data at 5 and/or 15 min time intervals over a 24 h period, provided a basis for comparison. The MSGMPE product was not very effective in the detection of very light and light rain events. Better results were obtained for the slightly

  20. A PARTICIPAÃÃO NA LISTA DE EMPRESAS COM MELHORES PRÃTICAS PARA COM OS FUNCIONÃRIOS E SEU IMPACTO NA PERFORMANCE: UM ESTUDO EMPÃRICO SOB A LÃGICA DA RBV (RESOURCE-BASED VIEW

    Directory of Open Access Journals (Sweden)

    Ludwig Miguel Agurto Berdejo

    2009-09-01

    Full Text Available Neste trabalho empírico, procuram-se evidências do impacto na performance das empresas decorrente da participação da organização na lista de empresas com melhores práticas para com os seus empregados (MPE. O trabalho sustenta-se no construto da resource-based view (RBV da empresa, estruturado em Barney (1991, entendendo a presença da empresa nas listagens de MPE como um recurso idiossincrático e difícil de ser imitado, o que leva a considerar este recurso como uma fonte de vantagem competitiva sustentável. O objetivo deste trabalho é verificar se a presença constante na lista de MPE no período de 2004 a 2006 proporciona uma performance financeira, medida pelo ROA e ROE, e de mercado, medida pelo Q de Tobin, superior em relação a um grupo de empresas comparáveis incluídas dentro de um grupo de controle. O período completo da análise compreende de 2001 a 2006, tendo sido testados 26 pares de empresas. Usando o Teste Wilcoxon, observouse que, para o ano de 2006, as amostras apresentam uma diferença significativa ao nível de 5% para o ROA e de 3% para o ROE evidenciando um melhor desempenho das empresas pertencentes à lista de MPE. Adicionalmente, usando a técnica de dados em painel, observou-se que a variável que denota a quantidade de participações que a empresa possui na listagem das MPE para o período de 2001 a 2006 apresenta significância para um nível menor do que 10%, contribuindo para o modelo do valor da empresa medido pelo Q de Tobin. Desta forma, este trabalho traz evidências que contribuem para demonstrar que a performance foi positivamente impactada pela sustentação de capacidades intangíveis e socialmente complexas. Com a sustentação destas capacidades podendo dificultar a sua imitação por concorrentes atuais e futuros.

  1. Experimental analysis of an air–water heat pump with micro-channel heat exchanger

    International Nuclear Information System (INIS)

    Brignoli, Riccardo; Cecchinato, Luca; Zilio, Claudio

    2013-01-01

    A multi-port extruded (MPE) aluminium flat tube air heat exchanger was compared to a round tube finned coil (FC). The MPE heat exchanger has parallel flow vertical tube configuration with headers in horizontal position and conventional folded louvred fins. The two heat exchangers were mounted on a 10 kW cooling capacity R410A packaged air heat pump. They were sized to approximately obtain the same cooling and heating capacities in chiller and heating mode, respectively. Climatic room steady state tests without frosting phenomena occurring during heat pump operation, demonstrated that the round tube and the flat tube heat exchanger performance are comparable. The MPE heat exchanger was tested with different refrigerant inlet distributor/outlet tubes configurations to investigate the effect of liquid refrigerant distribution. Cycling frosting/defrosting operations were tested with two equivalent machines placed in parallel outdoor and working at full load condition, one of the units was equipped with the MPE heat exchanger while the other mounted a standard finned coil. Penalization factors were analytically introduced to evaluate frosting associated heating energy and energy efficiency degradation. Test results indicate that both the heat pumps are penalized by frost formation but both the penalization factors are higher for the MPE-unit than the FC-unit one in the −6 to 4 °C air dry bulb temperature range. For the two units, a roughly linear dependence of the heating energy penalization factor and of the energy efficiency factor from the difference between outdoor air and saturated air at the evaporation temperature humidity ratio can be pointed out. - Highlights: ► A multi-port aluminium flat tube heat exchanger was compared to a round tube finned one in a heat pump application. ► In steady state tests without frosting the round and the flat tube heat exchanger are comparable. ► Different inlet distributor/outlet tubes configurations were tested to

  2. Depth-area-duration characteristics of storm rainfall in Texas using Multi-Sensor Precipitation Estimates

    Science.gov (United States)

    McEnery, J. A.; Jitkajornwanich, K.

    2012-12-01

    This presentation will describe the methodology and overall system development by which a benchmark dataset of precipitation information has been used to characterize the depth-area-duration relations in heavy rain storms occurring over regions of Texas. Over the past two years project investigators along with the National Weather Service (NWS) West Gulf River Forecast Center (WGRFC) have developed and operated a gateway data system to ingest, store, and disseminate NWS multi-sensor precipitation estimates (MPE). As a pilot project of the Integrated Water Resources Science and Services (IWRSS) initiative, this testbed uses a Standard Query Language (SQL) server to maintain a full archive of current and historic MPE values within the WGRFC service area. These time series values are made available for public access as web services in the standard WaterML format. Having this volume of information maintained in a comprehensive database now allows the use of relational analysis capabilities within SQL to leverage these multi-sensor precipitation values and produce a valuable derivative product. The area of focus for this study is North Texas and will utilize values that originated from the West Gulf River Forecast Center (WGRFC); one of three River Forecast Centers currently represented in the holdings of this data system. Over the past two decades, NEXRAD radar has dramatically improved the ability to record rainfall. The resulting hourly MPE values, distributed over an approximate 4 km by 4 km grid, are considered by the NWS to be the "best estimate" of rainfall. The data server provides an accepted standard interface for internet access to the largest time-series dataset of NEXRAD based MPE values ever assembled. An automated script has been written to search and extract storms over the 18 year period of record from the contents of this massive historical precipitation database. Not only can it extract site-specific storms, but also duration-specific storms and

  3. Maintenance proficiency evaluation test bank

    International Nuclear Information System (INIS)

    Maier, Loran

    2003-01-01

    The Maintenance Proficiency Evaluation Test Bank (MPETB) is an Electric Power Research Institute- (EPRJ-) operated, utility-sponsored means of developing, maintaining, and disseminating secure, high-quality written and performance maintenance proficiency tests. EPRTs charter is to ensure that all tests and test items that go into the Test Bank have been validated, screened for reliability, and evaluated to high standards of psychometric excellence. Proficiency tests of maintenance personnel.(mechanics, electricians, and instrumentation and control [I and C] technicians) are most often used to determine if an experienced employee is capable of performing maintenance tasks without further training. Such tests provide objective evidence for decisions to exempt an employee from what, for the employee, is unnecessary training. This leads to considerable savings in training costs and increased productivity because supervisors can assign personnel to tasks at which their competence is proven. The ultimate objective of proficiency evaluation is to ensure that qualified maintenance personnel are available to meet the maintenance requirements of the plant Numerous task-specific MPE tests (both written and performance) have been developed and validated using the EPRI MPE methodology by the utilities participating in the MPETB project A task-specific MPE consists of a multiple-choice written examination and a multi-step performance evaluation that can be used to assess an individual's present knowledge and skill level for a given maintenance task. The MPETB contains MPEs and test items for the mechanical, electrical, and I and C classifications that are readily available to participating utilities. Presently, utilities are placing emphasis on developing MPEs to evaluate outage-related maintenance tasks that demonstrate the competency and qualifications of plant and contractor personnel before the start of outage work. Utilities are also using the MPE methodology and process to

  4. ALOKASI PASOKAN BERDASARKAN PRODUK UNGGULAN UNTUK RANTAI PASOK SAYURAN SEGAR

    Directory of Open Access Journals (Sweden)

    Marimin Marimin

    2007-01-01

    Full Text Available Application of artificial inteligent by using fuzzy logic can be one of way to handle supply chain situation in uncertainty environment. It was widely concern to study a supply chain using fuzzy logic that most needed. Ain of the study was apply fuzzy logic in determination of supply allocation for superior product in vegetables supply chain. Models was developed in three sub models. First was determination vegetables types that superior by using pareto technique and exponential compaarison method (MPE. Second was expert system to determine supply needed and finally was optimizing supply allocation using fuzzy multi-objective linear programming. The model was applied in a vegetables agroindustry that superior product selected was red paprica. Analysis againts model behaviour is conducted for pesimistic and optimistic scenarios. Abstract in Bahasa Indonesia : Penerapan kecerdasan buatan dengan logika fuzzy bisa menjadi salah satu cara untuk mengatasi situasi rantai pasok dalam lingkungan ketidakpastian. Perhatian yang lebih luas untuk pembahasan rantai pasok menggunakan teknik fuzzy masih sangat dibutuhkan. Studi ini bertujuan menerapkan logika fuzzy dalam penentuan alokasi pasokan untuk produk unggulan pada rantai pasok agroindustri sayuran. Model yang terdiri dari tiga sub model. Sub model pertama adalah penentuan jenis sayuran yang diunggulkan menggunakan kombinasi teknik pareto dan metode perbandingan eksponensial (MPE. Sub model kedua adalah sistem pakar untuk menentukan kebutuhan pasokan menggunakan logika fuzzy. Sub model ketiga adalah optimasi alokasi pasokan menggunakan programa linear obyektif majemuk fuzzy. Model yang dibangun kemudian diterapkan pada sebuah perusahaan agroindustri sayuran dengan produk unggulan terpilih adalah paprika merah. Analisis terhadap prilaku model juga dilakukan untuk skenario pesimis dan optimis. Kata kunci: fuzzy, sistem pakar, MPE, obyektif majemuk, sayuran

  5. Mediastinoscope-controlled parasternal fenestration of the pericardium: definitive surgical palliation of malignant pericardial effusion

    Directory of Open Access Journals (Sweden)

    Toth Imre

    2012-06-01

    Full Text Available Abstract Background The tumorous infiltration or carcinosis of the pericardium could cause pericardial effusion in up to one-third of cases of malignancy, thus potentially interfere with the otherwise desirable oncological treatment. The existing surgical methods for the management of pericardial fluid are well-established but are not without limitations in the symptomatic relief of malignant pericardial effusion (MPE. The recurrence rate ranges between 43 and 69% after pericardiocentesis and 9 to 16% after pericardial drainage. The desire to overcome relative limitations of the existing methods led us to explore an alternative approach. Methods The standard armamentarium of the Carlens collar mediastinoscopy procedure was utilized in a Chamberlain parasternal approach of the pericardial sac. The laterality of approach was decided based upon the pleural involvement, as tumor-free pericardiopleural reflection is required. A pericardio-pleural window at least 3 cm in diameter was created. From January 2000 to December 2009, 22 cases were operated on with mediastinoscope-controlled parasternal fenestration (MCPF. Considering the type of the primary tumor, there were 11 lung cancer, 6 breast cancers, 2 haematologic malignancies and in 3 patients the origin of malignancy could not be verified. Results There were no operative deaths. We lost one patient (4.5% in the postoperative hospital period. All of the surviving patients had a minimum of 2 months of symptom-free survival. We detected transient recurrence of MPE in one patient (4.5% 14 days after the MCPF, which disappeared spontaneously after 24 hours. Conclusion The MCPF offers a real alternative in certain cases of pericardial effusion. We recommend this method especially for the definitive surgical palliation of MPE.

  6. Curcumin attenuates morphine antinociceptive tolerance through suppressing up-regulation of spinal Toll-like receptor 4 in rats

    Directory of Open Access Journals (Sweden)

    Fei GAO

    2017-12-01

    Full Text Available Objective To investigate the effects of curcumin (Cur on activation of spinal Toll-like receptor 4 (TLR4 and on the chronic antinociceptive tolerance of morphine. Methods Sixty male Sprague-Dawley rats with successful intrathecal catheterization were randomly divided into four groups (n=15: saline (NS group; morphine (MOR group; curcumin (Cur group and morphine plus curcumin (MOR+Cur group. A morphine tolerance model of rats was induced by intrathecal injection of morphine 15μg, once a day for 7 consecutive days in MOR and MOR+Cur group; 100μg curcumin was administered intrathecally once a day for 7 consecutive days in Cur and MOR+Cur group, 10μl saline was administered intrathecally once a day for 7 consecutive days in NS group. The effect of curcumin intrathecal catheterization on morphine antinociceptive tolerance was explored by the tail flick latency (TFL method and mechanical withdrawal threshold (MWT, and then the maximum possible potential effect (MPE was calculated. The immunofluorescence staining method was applied to detect the effect of curcumin on the activation of lumbar spinal microglia. Real-time PCR and Western blotting were used to evaluate the effect of curcumin on the expression of mRNA and protein of spinal TLR4. Results The %MPE TFL and %MPE MWT increased significantly in MOR+Cur group than in MOR group (P0.05. The lumbar spinal microglia increased markedly and the expressions of polyclonal antibody IBA-1 and TLR4 were significantly up-regulated in MOR group than in NS group (P0.05. Conclusion Curcumin may attenuate chronic morphine antinociceptive tolerance through inhibiting spinal TLR4 up-regulation. DOI: 10.11855/j.issn.0577-7402.2017.12.06

  7. A benchmarking project on the quality of previous guidelines about the management of malignant pleural effusion from the European Society of Thoracic Surgeons (ESTS) Pleural Diseases Working Group.

    Science.gov (United States)

    Bertolaccini, Luca; Bedetti, Benedetta; Brunelli, Alessandro; Marinova, Katerina; Raveglia, Federico; Rocco, Gaetano; Shargall, Yaron; Solli, Piergiorgio; Varela, Gonzalo; Papagiannopoulos, Kostas; Kuzdzal, Jaroslaw; Massard, Gilbert; Ruffini, Enrico; Falcoz, Pierre-Emmanuel; Martinez-Barenys, Carlos; Opitz, Isabelle; Batirel, Hasan F; Toker, Alper; Scarci, Marco

    2017-08-01

    In the European Society of Thoracic Surgeons (ESTS) survey about management of malignant pleural effusions (MPE), 56% of respondents are not informed of any relevant clinical guidelines and 52%, who are aware of the existence of guidelines, declared that they are in need of updating or revision. The ESTS Pleural Diseases Working Group developed a benchmarking project on quality of previous guidelines on the management of MPE. The Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument was used to assess each guideline. Each item was scored on a 7-point scale. Scores for each domain were calculated. Economic data for the nations which have issued the guidelines were collected from the Organisation for Economic Cooperation and Development health statistics database. Six guidelines fitted the inclusion criteria and were assessed. Five out of 6 guidelines were produced by a multinational collaboration. Observers would recommend only 2 guidelines with minimal modification. Two areas that received the best score were clarity of presentation and scope and purpose (objectives and health questions target population). The applicability of guideline domain had the lowest score. Multivariate analysis demonstrated that clarity of presentation, international guidelines and publication through medical journal were related to improved scores. A strong correlation was observed between the measures of economic status. The quality of guidelines assessed by the AGREE II criteria was found to be extremely variable. Guidelines achieving higher AGREE II scores were more likely to come from the European Union with the direct involvement of scientific societies in their development. It was also recognized that some fundamental unanswered questions remain about the management of MPE. © The Author 2017. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  8. The purpose of radiation protection monitoring

    International Nuclear Information System (INIS)

    Morgan, K.Z.

    1979-01-01

    In the early period (1942-1960) of nuclear energy programmes with which I was associated, most radiation protection standards seem to have been formulated on the assumption that there is a threshold dose of ionizing radiation below which no radiation damage is expected to result in the lifetime of the exposed individual. It was in this climate of opinion that health physics began as a profession, and levels of maximum permissible exposure (MPE) to external sources of radiation, maximum permissible concentrations in air, water and food, and maximum permissible body burdens of radionuclides inside the human body were set and enforced. Some of the levels of MPE were quite high in comparison with present standards but, fortunately, the health physicists at the national laboratories in which most radiation workers were employed were very conservative; in most cases the average annual exposures were less than 10% of the MPE levels. However, there was not much concern with the man-rem concept, as exemplified by rather high levels of radioactive waste discharged from the plants or placed in temporary holding facilities - where there was a likely possibility of seepage into the environment. This situation was understandable and justifiable at a time when the purpose of radiation protection monitoring was simply to prevent individuals from exceeding a threshold dose. The period of the recent past up to the present time (1978) has been one in which there has been a gradual change from the concept of a threshold dose hypothesis to the linear hypothesis. In this period the International Commission on Radiological Protection (ICRP) and the national standards setting bodies have pointed out that the levels they have selected are based on the linear hypothesis, but in most respects they leave us with the impression that this is most probably a conservative assumption, subject to revision when better data become available. Also, during this period, the concept of exposure As Low As

  9. Modeling extracellular matrix (ECM) alterations in ovarian cancer by multiphoton excited fabrication of stromal models (Conference Presentation)

    Science.gov (United States)

    Campagnola, Paul J.; Ajeti, Visar; Lara, Jorge; Eliceiri, Kevin W.; Patankar, Mansh

    2016-04-01

    A profound remodeling of the extracellular matrix (ECM) occurs in human ovarian cancer but it unknown how this affects tumor growth, where this understanding could lead to better diagnostics and therapeutic approaches. We investigate the role of these ECM alterations by using multiphoton excited (MPE) polymerization to fabricate biomimetic models to investigate operative cell-matrix interactions in invasion/metastasis. First, we create nano/microstructured gradients mimicking the basal lamina to study adhesion/migration dynamics of ovarian cancer cells of differing metastatic potential. We find a strong haptotactic response that depends on both contact guidance and ECM binding cues. While we found enhanced migration for more invasive cells, the specifics of alignment and directed migration also depend on cell polarity. We further use MPE fabrication to create collagen scaffolds with complex, 3D submicron morphology. The stromal scaffold designs are derived directly from "blueprints" based on SHG images of normal, high risk, and malignant ovarian tissues. The models are seeded with different cancer cell lines and this allows decoupling of the roles of cell characteristics (metastatic potential) and ECM structure and composition (normal vs cancer) on adhesion/migration dynamics. We found the malignant stroma structure promotes enhanced migration and proliferation and also cytoskeletal alignment. Creating synthetic models based on fibers patterns further allows decoupling the topographic roles of the fibers themselves vs their alignment within the tissue. These models cannot be synthesized by other conventional fabrication methods and we suggest the MPE image-based fabrication method will enable a variety of studies in cancer biology.

  10. Substantial Differences between Organ and Muscle Specific Tracer Incorporation Rates in a Lactating Dairy Cow.

    Directory of Open Access Journals (Sweden)

    Nicholas A Burd

    Full Text Available We aimed to produce intrinsically L-[1-(13C]phenylalanine labeled milk and beef for subsequent use in human nutrition research. The collection of the various organ tissues after slaughter allowed for us to gain insight into the dynamics of tissue protein turnover in vivo in a lactating dairy cow. One lactating dairy cow received a constant infusion of L-[1-(13C]phenylalanine (450 µmol/min for 96 h. Plasma and milk were collected prior to, during, and after the stable isotope infusion. Twenty-four hours after cessation of the infusion the cow was slaughtered. The meat and samples of the various organ tissues (liver, heart, lung, udder, kidney, rumen, small intestine, and colon were collected and stored. Approximately 210 kg of intrinsically labeled beef (bone and fat free with an average L-[1-(13C]phenylalanine enrichment of 1.8±0.1 mole percent excess (MPE was obtained. The various organ tissues differed substantially in L-[1-(13C]phenylalanine enrichments in the tissue protein bound pool, the highest enrichment levels were achieved in the kidney (11.7 MPE and the lowest enrichment levels in the skeletal muscle tissue protein of the cow (between 1.5-2.4 MPE. The estimated protein synthesis rates of the various organ tissues should be regarded as underestimates, particularly for the organs with the higher turnover rates and high secretory activity, due to the lengthened (96 h measurement period necessary for the production of the intrinsically labeled beef. Our data demonstrates that there are relatively small differences in L-[1-(13C]phenylalanine enrichments between the various meat cuts, but substantial higher enrichment values are observed in the various organ tissues. We conclude that protein turnover rates of various organs are much higher when compared to skeletal muscle protein turnover rates in large lactating ruminants.

  11. Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering

    Directory of Open Access Journals (Sweden)

    Hairong Wang

    2017-10-01

    Full Text Available Bone tissue engineering widely explores the use of ceramic reinforced polymer-matrix composites. Among the various widely-used ceramic reinforcements, hydroxyapatite is an undisputed choice due to its inherent osteoconductive nature. In this study, a novel nanocomposite comprising metallocene polyethylene (mPE incorporated with nano-hydroxyapaptite nanorods (mPE-nHA was synthesized and dip coated with Aloe vera after subjecting it to microwave treatment. The samples were characterized using contact angle, Fourier transform infrared spectroscopy (FTIR, scanning electron microscope (SEM, atomic force microscopy (AFM and 3D Hirox microscopy scanning. Contact angle results show that the hydrophilicity of mPE-nHA improved notably with the coating of Aloe vera. The surface topology and increase in surface roughness were observed using the SEM, AFM and 3D Hirox microscopy. Blood compatibility assays of pure mPE and the Aloe vera coated nanocomposite were performed. The prothrombin time (PT was delayed by 1.06% for 24 h Aloe-vera-treated mPE-nHA compared to the pristine mPE-nHA. Similarly, the 24 h Aloe-vera-coated mPE-nHA nanocomposite prolonged the activated partial thromboplastin time (APTT by 41 s against the control of pristine mPE-nHA. The hemolysis percentage was also found to be the least for the 24 h Aloe-vera-treated mPE-nHA which was only 0.2449% compared to the pristine mPE-nHA, which was 2.188%. To conclude, this novel hydroxyapatite-reinforced, Aloe-vera-coated mPE with a better mechanical and anti-thrombogenic nature may hold a great potential to be exploited for bone tissue engineering applications.

  12. Cellular and molecular responses of adult zebrafish after exposure to CuO nanoparticles or ionic copper.

    Science.gov (United States)

    Vicario-Parés, Unai; Lacave, Jose M; Reip, Paul; Cajaraville, Miren P; Orbea, Amaia

    2018-01-01

    Due to their antimicrobial, electrical and magnetic properties, copper nanoparticles (NPs) are suitable for a vast array of applications. Copper can be toxic to biota, making it necessary to assess the potential hazard of copper nanomaterials. Zebrafish (Danio rerio) were exposed to 10 µg Cu/L of CuO NPs of ≈100 nm (CuO-poly) or ionic copper to compare the effects provoked after 3 and 21 days of exposure and at 6 months post-exposure (mpe). At 21 days, significant copper accumulation was only detected in fish exposed to ionic copper. Exposure to both copper forms caused histopathological alterations that could reduce gill functionality, more markedly in the case of ionic copper. Nevertheless, at 6 mpe higher prevalences of gill lesions were detected in fish previously exposed to CuO-poly NPs. No relevant histological alterations were detected in liver, but the lysosomal membrane stability test showed significantly impaired general health status after exposure to both metal forms that lasted up to 6 mpe. 69 transcripts appeared regulated after 3 days of exposure to CuO-poly NPs, suggesting that NPs could produce oxidative stress and reduce metabolism and transport processes. Thirty transcripts were regulated after 21 days of exposure to ionic copper, indicating possible DNA damage. Genes of the circadian clock were identified as the key genes involved in time-dependent differences between the two copper forms. In conclusion, each copper form showed a distinct pattern of liver transcriptome regulation, but both caused gill histopathological alterations and long lasting impaired health status in adult zebrafish.

  13. Comparative metabolomics analysis for the compatibility and incompatibility of kansui and licorice with different ratios by UHPLC-QTOF/MS and multivariate data analysis.

    Science.gov (United States)

    Shen, Juan; Pu, Zong-Jin; Kai, Jun; Kang, An; Tang, Yu-Ping; Shang, Li-Li; Zhou, Gui-Sheng; Zhu, Zhen-Hua; Shang, Er-Xin; Li, Shao-Ping; Cao, Yu-Jie; Tao, Wei-Wei; Su, Shu-Lan; Zhang, Li; Zhou, Huiping; Qian, Da-Wei; Duan, Jin-Ao

    2017-07-01

    Kansui, the root of Euphorbia kansui T.N. Liou ex T.P. Wang (Euphorbiaceae), is a well-known poisonous traditional Chinese medicine (TCM). However, many monographs of TCM indicated that it cannot be co-used with licorice, as kansui-licorice is a typical "eighteen incompatible" medicaments. Our previous studies have indicated that kansui was effective in treating malignant pleural effusion (MPE), and the efficacy could be weakened by the co-use of licorice, even causing serious toxicity at the given ratio. Nevertheless, the actual mechanisms of their dosage-toxicity-efficacy relationship need to be well clarified. The present study aimed to investigate the effect of individual and combined use of kansui and licorice on MPE rats, and explain the underlying mechanisms from a metabolomic perspective. Urine samples were analyzed by ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC-QTOF/MS). Partial least-squares discriminate analysis (PLS-DA) models were built to evaluate the interaction between kansui and licorice. Seven potential biomarkers contribute to the separation of model group and control group were tentatively identified. And selenoamino acid metabolism and nicotinate and nicotinamide metabolism with the impact-value 0.31 and 0.24, respectively, were filtered out as the most important metabolic pathways. Kansui and kansui-licorice at a ratio of 4:1 can treat MPE rats by adjusting abnormal metabolic pathways to the normal state, while it may have opposite result with kansui-licorice 1:4. The different influences to the two metabolic pathways may partially explain the dosage-toxicity-efficacy relationship of kansui-licorice with different ratios. The results could offer valuable insights into the compatibility property changes for the two herbs. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Sensitivity of Beauveria bassiana conidia to abiotic factors after successive in vitro subcultures

    Directory of Open Access Journals (Sweden)

    Janaina Zorzetti

    2014-09-01

    Full Text Available The aim of this study was to evaluate the effect of in vitro successive subcultures of Beauveria bassiana isolates in different nutritional conditions on conidia heat and UV radiation tolerance and on sensitivity to azoxystrobin fungicide. The fungus was initially inoculated in Alphitobius diaperinus (Coleoptera: Tenebrionidae adults and after its development, the conidia were cultivated in PDA (potato dextrose agar and MPE (medium to produce Beauveria spp. conidia originating the first subculture 1st (A conidia, which were successively multiplied in their media until the 20th cultivation. Conidia taken from the 20th subculture were again inoculated in the insect and after sporulation they were once more multiplied in the media, producing the 1st (B conidia. For the tests, 1st (A, 10th, 20th and 1st (B conidia from the CG 152 and Unioeste 40 isolates were used. Successive subcultures and the medium nutritional conditions interfered on the fungus physiology, and the isolates showed different behaviors. The subcultures on PDA showed higher thermotolerance to Unioeste 40 in all subcultures and to CG 152 just after inoculation in the host. B. bassiana was susceptible to UV radiation, and this characteristic was influenced by the subcultures in different media. Both isolates were more tolerant to UV radiation when subcultivated on MPE, while just for the 40 Unioeste this tolerance increased after host inoculation. The B. bassiana sensitivity to azoxystrobin fungicide was affected after successive subcultures in both medium. Conidia originated in MPE were more resistant to fungicide and the host inoculation increased this tolerance. These results show that it is possible to enhance the fungi efficiency to control pests, through the selection of a virulent isolate, and handling their nutritional conditions during cultivation and host inoculation.

  15. Diagnostic value of tumor markers for lung adenocarcinoma-associated malignant pleural effusion: a validation study and meta-analysis.

    Science.gov (United States)

    Feng, Mei; Zhu, Jing; Liang, Liqun; Zeng, Ni; Wu, Yanqiu; Wan, Chun; Shen, Yongchun; Wen, Fuqiang

    2017-04-01

    Pleural effusion is one of the most common complications of lung adenocarcinoma and is diagnostically challenging. This study aimed to investigate the diagnostic performance of carcinoembryonic antigen (CEA), cytokeratin fragment (CYFRA) 21-1, and cancer antigen (CA) 19-9 for lung adenocarcinoma-associated malignant pleural effusion (MPE) through a validation study and meta-analysis. Pleural effusion samples were collected from 81 lung adenocarcinoma-associated MPEs and 96 benign pleural effusions. CEA, CYFRA 21-1, and CA19-9 were measured by electrochemiluminescence immunoassay. The capacity of tumor markers was assessed with receiver operating characteristic curve analyses and the area under the curve (AUC) was calculated. Standard methods for meta-analysis of diagnostic studies were used to summarize the diagnostic performance of CEA, CYFRA 21-1, and CA19-9 for lung adenocarcinoma-associated MPE. The pleural levels of CEA, CYFRA 21-1, and CA19-9 were significantly increased in lung adenocarcinoma-associated MPE compared to benign pleural effusion. The cut-off points for CEA, CYFRA 21-1, and CA19-9 were optimally set at 4.55 ng/ml, 43.10 μg/ml, and 12.89 U/ml, and corresponding AUCs were 0.93, 0.85, and 0.81, respectively. The combination of CEA, CYFRA 21-1, and CA19-9 increased the sensitivity to 95.06%, with an AUC of 0.95. Eight studies were included in this meta-analysis. CEA showed the best diagnostic performance with pooled sensitivity, specificity, positive/negative likelihood ratio, and diagnostic odds ratio of 0.75, 0.96, 16.01, 0.23, and 81.49, respectively. The AUC was 0.93. CEA, CYFRA 21-1, and CA19-9 play a role in the diagnosis of lung adenocarcinoma-associated MPE. The combination of these tumor markers increases the diagnostic accuracy.

  16. Very High Performance Organic Photonic Devices

    Science.gov (United States)

    2008-01-15

    thought complexity from left (simplest) to right (most complex). Monomeric compounds ( eft ), possible in the world of inorganic semiconductors. Many...60 ±10 4 7 Sht"it M. M.pe) J et 7 r. B 45 lF,xi S R Eft -Ats. hin I 1,,y,)o I jim-.1). Planar OPD TIo Ilion-f~i, , o... App. PM, Leiw 81. 268-270 (Z...of SnPc deposited on ITO, taken in the 0-20 geometry using Cu Kr S.R radiation. (b) Scanning electron microscope (SEM) and tapping moole SR. Forrest

  17. Taegu AB, Korea. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A, C-F.

    Science.gov (United States)

    1981-10-07

    o -’./ ŗ I 6M 1(TAL 17.; 59.119.1 4. ,7676 - - - - 766 1766 El.,,.., IX) Zl’ Z 1 Ib*Ne Obra . Mie.. Ne. of H4e.e. vlii T.,mpe..thw. U...4 27 38 / 3 2 2 9 42 j ’/ 17 .1 1 1 4 ’? ! lI 15 .1 1 1 43 . 13 .1 1 1 1 34 1 11 .11 13 24 1 7 : 1 5 ./ I2 TT6 VIAL 1.625. g4.*󈧜 6. 6 .1 752 744 6

  18. QPS - analysis of main problems, areas to target, possible improvements

    CERN Document Server

    Denz, R

    2012-01-01

    The fault statistics of the LHC Quench Protection System QPS for the LHC run 2011 will be presented and the various fault types explained. Starting with teething and EMC related problems, the tune feedback compatibility, hardware faults of the quench heater power supplies and spurious openings of electrical circuit breakers will be described in more details. Hereby as well the necessary and potential consolidation measures will be discussed. The role of the MPE standby service for the system availability will be addressed. Finally radiation induced faults and the respective mitigation and consolidation measures will be treated as separate subject.

  19. Monitoramento e controle de projetos de desenvolvimento de software para micro e pequenas empresa alinhado ao PMBOK e CMMI

    OpenAIRE

    Pereira, André Marques

    2012-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Ciência de Computação, Florianópolis, 2012. Muitas empresas falham no desenvolvimento de seus projetos e muito se deve a falta de maturidade de seus processos. Analisando o cenário das Micro e Pequenas Empresas (MPE), muitas vezes inexiste alinhamento à modelos e normas atualmente em evidência, talvez explicado pelo fato de que os modelos podem ser muito abrangentes para o cont...

  20. Implementation of Automatic Clustering Algorithm and Fuzzy Time Series in Motorcycle Sales Forecasting

    Science.gov (United States)

    Rasim; Junaeti, E.; Wirantika, R.

    2018-01-01

    Accurate forecasting for the sale of a product depends on the forecasting method used. The purpose of this research is to build motorcycle sales forecasting application using Fuzzy Time Series method combined with interval determination using automatic clustering algorithm. Forecasting is done using the sales data of motorcycle sales in the last ten years. Then the error rate of forecasting is measured using Means Percentage Error (MPE) and Means Absolute Percentage Error (MAPE). The results of forecasting in the one-year period obtained in this study are included in good accuracy.

  1. Review of Electromagnetic Frequency (EMF) Safety Program for Homestead ARB, FL

    Science.gov (United States)

    2012-11-28

    using technique number MSL-7. Calibrations below I GHz were perfonned in a electrical characterist.ics of the cell and the measured net power...Altimeter ( CARA ) 1 per F-16 4 .2-4.2 GHz 100/10 0 .8 2 .4 482 AMXS/MXAAS AN/APG68 Fire Control Radar (FCR) 1 per F-1 6 Classified Classified Classified...A. MPE fot· Upper T ier Electric Magnetic field Powet· Averaging Fr equency Field - nns strength - n ns Density - nns (S) time R ange (t) (E

  2. Liquid and gas chromatography coupled to isotope ratio mass spectrometry for the determination of 13C-valine isotopic ratios in complex biological samples.

    Science.gov (United States)

    Godin, Jean-Philippe; Breuillé, Denis; Obled, Christiane; Papet, Isabelle; Schierbeek, Henk; Hopfgartner, Gérard; Fay, Laurent-Bernard

    2008-10-01

    On-line gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS) is commonly used to measure isotopic ratios at natural abundance as well as for tracer studies in nutritional and medical research. However, high-precision (13)C isotopic enrichment can also be measured by liquid chromatography-isotope ratio mass spectrometry (LC-IRMS). Indeed, LC-IRMS can be used, as shown by the new method reported here, to obtain a baseline separation and to measure (13)C isotopic enrichment of underivatised amino acids (Asp, Thr-Ser, Glu, Pro, Gly, Ala, Cys and Val). In case of Val, at natural abundance, the SD(delta(13)C) reported with this method was found to be below 1 per thousand . Another key feature of the new LC-IRMS method reported in this paper is the comparison of the LC-IRMS approach with the conventional GC-C-IRMS determination. To perform this comparative study, isotopic enrichments were measured from underivatised Val and its N(O, S)-ethoxycarbonyl ethyl ester derivative. Between 0.0 and 1.0 molar percent excess (MPE) (delta(13)C= -12.3 to 150.8 per thousand), the calculated root-mean-square (rms) of SD was 0.38 and 0.46 per thousand and the calculated rms of accuracy was 0.023 and 0.005 MPE, respectively, for GC-C-IRMS and LC-IRMS. Both systems measured accurately low isotopic enrichments (0.002 atom percent excess (APE)) with an SD (APE) of 0.0004. To correlate the relative (delta(13)C) and absolute (atom%, APE and MPE) isotopic enrichment of Val measured by the GC-C-IRMS and LC-IRMS devices, mathematical equations showing the slope and intercept of the curves were established and validated with experimental data between 0.0 to 2.3 MPE. Finally, both GC-C-IRMS and LC-IRMS instruments were also used to assess isotopic enrichment of protein-bound (13)C-Val in tibial epiphysis in a tracer study performed in rats. Isotopic enrichments measured by LC-IRMS and GC-C-IRMS were not statistically different (p>0.05). The results of this work indicate that

  3. Hard X-ray balloon observations of compact galactic and extragalactic X-ray sources

    International Nuclear Information System (INIS)

    Staubert, R.; Kendziorra, E.; Pietsch, W.; Proctor, R.J.; Reppin, C.; Steinle, H.; Truemper, J.; Voges, W.

    1981-01-01

    A balloon program in hard X-ray astronomy (20-200 keV) is jointly pursued by the Astronomisches Institut der Universitaet Tuebingen (AIT) and the Max Planck-Institut fuer Extraterrestrische Physik in Garching (MPE). Since 1973 nine succussful balloon flights have been performed from Texas and Australia. Here results on Centaurus A and on several galactic binary X-ray sources are summarized. In particular the high energy photon spectrum of Hercules X-1 and the evidence for the cyclotron line feature which was discovered by us in 1976 is reviewed. (orig.)

  4. Uso e Percepção de Licitude de Práticas Ilegais ou Antiéticas de Sobrevivência de Micro e Pequenas Empresas

    Directory of Open Access Journals (Sweden)

    Sérgio Henrique Arruda Cavalcante Forte

    2015-11-01

    Full Text Available Segundo o Sebrae (2013, a taxa de sobrevivência das Micro e Pequenas Empresas (MPE no Brasil vem melhorando, com sobrevivência de 75,6% nos primeiros dois anos de vida. Das sobreviventes, muitas enfrentam dificuldades no mercado, tendo que por vezes optar para o uso de práticas ilícitas ou antiéticas e ainda não se considerando “fora da lei”. Nesse contexto, o objetivo geral é relacionar o uso das práticas ilegais ou antiéticas utilizadas pelas MPE para sobreviverem com a percepção de ilicitude dessas práticas. Esta pesquisa é do tipo descritiva e quantitativa. Após levantamento bibliográfico e pesquisa exploratória com 17 MPE foi realizada uma pesquisa de campo com 102 MPE, com a aplicação de um questionário com 33 variáveis de práticas ilegais ou antiéticas, onde as práticas deveriam ser avaliadas pelo respondente com base no comportamento observado de seus concorrentes, por meio de uma escala Likert, de cinco pontos. Pode-se concluir que todas as práticas investigadas estão sendo utilizadas em algum grau pelos empreendedores, cabendo destacar que para apenas quatro das 33 práticas a percepção de ilicitude se apresentou menor que a de licitude, evidenciando que a maioria (29 de 33 práticas vem sendo utilizada mesmo tendo-se a consciência de que são ilícitas. Pode-se concluir também que das nove práticas destacadas, cinco delas referem-se à evasão fiscal. Percebeu-se que as práticas que ferem diretamente o interesse do consumidor não são vistas como “ilícitas” pelos empreendedores.

  5. The dynamics of climate agreements

    Energy Technology Data Exchange (ETDEWEB)

    Harstadt, Baard [Northwestern Univ., Evanston, IL (United States). Kellogg School of Management

    2010-02-15

    I develop a dynamic model of private provision of public bads allowing investments in technologies. The analysis is tractable and the MPE unique. The framework is used to derive optimal incomplete contracts in a dynamic setting. While the noncooperative equilibrium is very inefficient, short-term contracts can be worse due to hold-up problems. The optimal long-term contract is more ambitious if its length is relatively short and the technological spillover large. The optimal length increases in this externality. With renegotiation, the outcome is first best. The results have several implications for how to design a climate treaty. (orig.)

  6. Staff Association membership is free of charge for the rest of 2017

    CERN Multimedia

    Staff Association

    2017-01-01

    Starting from September 1st, membership of the Staff Association is free for all new members for the period up to the end of 2017. This is to allow you to participate in the Staff Council elections. Indeed, only Employed Members of the Personnel (MPE: staff and fellows) and Associated Members of the Personnel (MPA), who are members of the Staff Association, can: stand for election and become a delegate of the personnel; vote and elect their representatives to the Staff Council. Do not hesitate any longer; join now!

  7. The Tenth International Workshop on MULTIFREQUENCY BEHAVIOUR OF HIGH ENERGY COSMIC SOURCES Palermo, Italy, 2013

    Directory of Open Access Journals (Sweden)

    Editorial, Foreword

    2014-12-01

    Full Text Available Organizing Institutions:Istituto di Astrofisica e Planetologia Spaziali IAPS-INAF, Roma, ItalyDpt de Cargas Utiles y Ciencias del Espacio, DCUCE-INTA Madrid, SpainE.O. Hulburt Center for Space Research, HCA-NRL, Washington D.C., USAMax-Planck Institut fr Extraterrestrische Physik, MPE, Garching, GermanySt. John’s College, SJC, Annapolis MD, USAInstitute für Astronomie und Astrophysik, Karls Eberhard, Universität SAND 1, Tübingen, GermanyASCR - Astronomical Institute, Ondřejov, Czech RepublicCTU - Czech Technical University, Prague, Czech Republic

  8. Efficient and simple production of insulin-producing cells from embryonal carcinoma stem cells using mouse neonate pancreas extract, as a natural inducer.

    Directory of Open Access Journals (Sweden)

    Marzieh Ebrahimie

    Full Text Available An attractive approach to replace the destroyed insulin-producing cells (IPCs is the generation of functional β cells from stem cells. Embryonal carcinoma (EC stem cells are pluripotent cells which can differentiate into all cell types. The present study was carried out to establish a simple nonselective inductive culture system for generation of IPCs from P19 EC cells by 1-2 weeks old mouse pancreas extract (MPE. Since, mouse pancreatic islets undergo further remodeling and maturation for 2-3 weeks after birth, we hypothesized that the mouse neonatal MPE contains essential factors to induce in vitro differentiation of pancreatic lineages. Pluripotency of P19 cells were first confirmed by expression analysis of stem cell markers, Oct3/4, Sox-2 and Nanog. In order to induce differentiation, the cells were cultured in a medium supplemented by different concentrations of MPE (50, 100, 200 and 300 µg/ml. The results showed that P19 cells could differentiate into IPCs and form dithizone-positive cell clusters. The generated P19-derived IPCs were immunoreactive to proinsulin, insulin and insulin receptor beta. The expression of pancreatic β cell genes including, PDX-1, INS1 and INS2 were also confirmed. The peak response at the 100 µg/ml MPE used for investigation of EP300 and CREB1 gene expression. When stimulated with glucose, these cells synthesized and secreted insulin. Network analysis of the key transcription factors (PDX-1, EP300, CREB1 during the generation of IPCs resulted in introduction of novel regulatory candidates such as MIR17, and VEZF1 transcription factors, as well as MORN1, DKFZp761P0212, and WAC proteins. Altogether, we demonstrated the possibility of generating IPCs from undifferentiated EC cells, with the characteristics of pancreatic β cells. The derivation of pancreatic cells from EC cells which are ES cell siblings would provide a valuable experimental tool in study of pancreatic development and function as well as rapid

  9. Clinical value of jointly detection serum lactate dehydrogenase/pleural fluid adenosine deaminase and pleural fluid carcinoembryonic antigen in the identification of malignant pleural effusion.

    Science.gov (United States)

    Zhang, Fan; Hu, Lijuan; Wang, Junjun; Chen, Jian; Chen, Jie; Wang, Yumin

    2017-09-01

    Limited data are available for the diagnostic value, and for the diagnostic sensitivity and specificity of joint detection of serum lactate dehydrogenase (sLDH)/pleural fluid adenosine deaminase (pADA) and pleural fluid carcinoembryonic antigen (pCEA) in malignant pleural effusion (MPE). We collected 987 pleural effusion specimens (of which 318 were malignant pleural effusion, 374 were tubercular pleural effusion, and 295 were parapneumonic effusion specimens) from the First Affiliated Hospital of Wenzhou Medical University from July 2012 to March 2016. The pADA, sLDH, pleural fluid LDH (pLDH), serum C-reactive protein (sCRP), pleural fluid protein, pCEA, white blood cell (WBC), and red blood cell (RBC) were analyzed, and the clinical data of each group were collected for statistical analysis. The level of sLDH/pADA, pCEA, and RBC from the MPE group was markedly higher than the tuberculosis pleural effusion (TB) group (Mann-Whitney U=28422.000, 9278.000, 30518, P=.000, .000, .000) and the parapneumonic pleural fluid group (Mann-Whitney U=5972.500, 7113.000, 36750.500, P=.000, .000, .000). The receiver operating characteristic curve ROC showed that the area under the ROC curve (AUC) (=0.924, 0.841) of pCEA and sLDH/pADA (cutoff=4.9, 10.6) were significantly higher than other markers for the diagnosis of MPE. Thus, joint detection of pCEA and sLDH/pADA suggested that the sensitivity, specificity, and AUC was 0.94, 81.70, and 94.32 at the cutoff 0.16 and diagnostic performance was higher than pCEA or sLDH/pADA. Joint detection of sLDH/pADA and pCEA can be used as a good indicator for the identification of benign and MPE with higher sensitivity and specificity than pCEA or sLDH/pADA. © 2016 Wiley Periodicals, Inc.

  10. A survey of the urban radiofrequency (RF) environment

    International Nuclear Information System (INIS)

    Tell, Richard A.; Kavet, Robert

    2014-01-01

    In 1980, Tell and Mantiply published a study of radiofrequency (RF) fields measured across 15 major metropolitan areas in the USA. They required a van fully equipped with instrumentation and computing capability for their measurements. This study aimed to assess whether and how hand-held instrumentation available today would facilitate and enhance the efficiency of large-scale surveys of ambient RF fields. In addition, the data would provide a suggestion as to how the profile of ambient RF fields has changed with respect to frequency content and magnitude. Not unexpectedly, the relative power densities were orders of magnitude lower than the Federal Communications Commission's (FCC) maximum permissible exposure (MPE) for the general public, with a maximum time-averaged value across the VHF-FM-UHF-cellular bands of 0.12 % of the MPE (AM's contribution was negligible). In both the 1980 and the present study, the power density in the FM band was a major contributor to overall power density, but over time, power densities in the VHF and UHF band decreased and increased, respectively. From the perspective of absolute power density, the wideband values in the 1980 study, this study and any number of assessments conducted in European nations are not generally different from one another. (authors)

  11. EUTEMPE-RX, an EC supported FP7 project for the training and education of medical physics experts in radiology

    International Nuclear Information System (INIS)

    Bosmans, H.; Van Peteghem, N.; Bliznakova, K.; Vassileva, J.; Padovani, R.; Christofides, S.; Tsapaki, V.; Caruana, C.J.

    2015-01-01

    The core activity of the medical physics expert (MPE) is to ensure optimal use of ionising radiation in health care. It is essential that these health care professionals are trained to the highest level, defined as European Qualifications Framework for Lifelong Learning (EQF) level 8 by the European Commission's Radiation Protection Report 174 'Guidelines on the MPE'. The main objective of the EUTEMPE-RX project is to provide a model training scheme that allows the medical physicist in diagnostic and interventional radiology (D and IR) to reach this high level. A European network of partners was brought together in this FP7 EC project to ensure sufficient expertise in all aspects of the subject and to create a harmonised course programme. Targeted participants are medical physicists in D and IR in hospitals, engineers and scientists in medical device industries and officers working in regulatory authorities. Twelve course modules will be developed at EQF level 8, with radiation safety and diagnostic effectiveness being prevalent subjects. The modules will combine online with face-to-face teaching using a blended learning approach. (authors)

  12. Effect of NiO inserted layer on spin-Hall magnetoresistance in Pt/NiO/YIG heterostructures

    International Nuclear Information System (INIS)

    Shang, T.; Zhan, Q. F.; Yang, H. L.; Zuo, Z. H.; Xie, Y. L.; Liu, L. P.; Zhang, S. L.; Zhang, Y.; Li, H. H.; Wang, B. M.; Li, Run-Wei; Wu, Y. H.; Zhang, S.

    2016-01-01

    We investigate spin-current transport with an antiferromagnetic insulator NiO thin layer by means of the spin-Hall magnetoresistance (SMR) over a wide range of temperature in Pt/NiO/Y_3Fe_5O_1_2 (Pt/NiO/YIG) heterostructures. The SMR signal is comparable to that without the NiO layer as long as the temperature is near or above the blocking temperature of the NiO, indicating that the magnetic fluctuation of the insulating NiO is essential for transmitting the spin current from the Pt to YIG layer. On the other hand, the SMR signal becomes negligibly small at low temperature, and both conventional anisotropic magnetoresistance and the anomalous Hall resistance are extremely small at any temperature, implying that the insertion of the NiO has completely suppressed the Pt magnetization induced by the YIG magnetic proximity effect (MPE). The dual roles of the thin NiO layer are, to suppress the magnetic interaction or MPE between Pt and YIG, and to maintain efficient spin current transmission at high temperature.

  13. Rancang Bangun Transportasi Logistik Kakao Agroindustri Coklat Kabupaten Pidie Jaya Provinsi Aceh

    Directory of Open Access Journals (Sweden)

    Yusriana Yusriana

    2013-02-01

    Full Text Available Factual problems of the cocoa bean agroindustry at Pidie Jaya District, Aceh Province were large distances between farmers and processor, thus determining the shortest part route, backhaul location and quality risk becomes critically to the assess. The objective this research are to determine shortest route based on the location of suppliers, back location, and risk quality recommendations. Requirement of shortest part route solved by Algorithm Djisktra, Backhaul location with MPE and Risk management quality by Multi Expert Multi Criteria Decision Making, aggregation criteria with OWA. The result of the study shows that the shortest distance suppliers Aceh Timur District was 282km, Aceh Utara District 116km, Bireuen District 57km, Pidie District 24km and Aceh Tenggara District 391km. Backhaul location sat Aceh Tengah District with a value of MPE(6533. Alternative of quality risk management were direct fermentation, improvement of transport facilities and container with a high rating criteria, thus the agroindustry has to focus on this dimension.

  14. News regarding Mobility at CERN

    CERN Multimedia

    2016-01-01

    CERN Bikes CERN owns a fleet of more than 500 bikes, managed by the Mobility Centre (bdg. 6167). Members of CERN personnel (MPE and MPA) can use these free of charge during work-related activities at CERN (a security deposit is requested). Between 1st of June to 30th September anyone, except Summer Students, who wish to benefit from this service shall pay 1 CHF per day. As from the 1st of August, the CERN bike rental requests are done via the Service Now (SNOW) Portal. For more information, please consult: http://cern.ch/bike-rental.   CERN Cars More than 60 vehicles are available for rent by members of personnel (MPE and MPA) at the Mobility Center (bdg. 6167). As from the 5th of September you can submit reservation requests via the new EDH Car Rental Request document. As a reminder, the Terms of Use are the following: Operational Circular n° 4 (rev.1), governing the use of CERN vehicles;   Any use of the service must be authorised by the concerned Head of Department or Team Leader...

  15. Detection of EpCAM-positive microparticles in pleural fluid: A new approach to mini-invasively identify patients with malignant pleural effusions.

    Science.gov (United States)

    Roca, Elisa; Lacroix, Romaric; Judicone, Coralie; Laroumagne, Sophie; Robert, Stéphane; Cointe, Sylvie; Muller, Alexandre; Kaspi, Elise; Roll, Patrice; Brisson, Alain R; Tantucci, Claudio; Astoul, Philippe; Dignat-George, Françoise

    2016-01-19

    Pleural biomarkers allowing to mini-invasively discriminate benign from malignant pleural effusions are needed. Among potential candidates, microparticles (MPs) are extracellular vesicles that vectorize antigen derived from the parent cell. We hypothesized that tumor-derived MPs could be present in the pleural liquid and help to identify patients with malignant pleural effusions. Using highly sensitive flow cytometry and cryo-electron microscopy, we showed that large amounts of MPs from hematopoïetic and vascular origin could be detectable in pleural fluids. Their level did not differ between benign (n = 14) and malignant (n = 71) pleural effusions. Analysis of selected tumoral associated antigens (podoplanin, mucin 1 and EpCAM, epithelial-cell-adhesion-molecule) evidenced for the first time the presence of tumor-derived MPs expressing EpCAM in malignant pleural fluids only (Specificity = 93%, Sensitivity = 49% and 45% for flow cytometry and ELISA, respectively). The detection of EpCAM-positive-MPs (EpCAM + MPs) by flow cytometry showed a better specificity and sensitivity than ELISA to distinguish between pleural carcinoma and the others malignant pleural effusions (MPE; Sp: 96% vs 89%; Se: 79% vs 66%). Combining EpCAM+ MPs and cytology improved the diagnosis of MPE compared to cytology alone. This study establishes the basis for using EpCAM+ MPs as a promising new biomarker that could be added to the armamentarium to mini-invasively identify patients with malignant pleural effusions.

  16. Environmental assessment of garden waste management in the Municipality of Aarhus, Denmark

    International Nuclear Information System (INIS)

    Boldrin, Alessio; Andersen, Jacob K.; Christensen, Thomas H.

    2011-01-01

    An environmental assessment of six scenarios for handling of garden waste in the Municipality of Aarhus (Denmark) was performed from a life cycle perspective by means of the LCA-model EASEWASTE. In the first (baseline) scenario, the current garden waste management system based on windrow composting was assessed, while in the other five scenarios alternative solutions including incineration and home composting of fractions of the garden waste were evaluated. The environmental profile (normalised to Person Equivalent, PE) of the current garden waste management in Aarhus is in the order of -6 to 8 mPE Mg -1 ww for the non-toxic categories and up to 100 mPE Mg -1 ww for the toxic categories. The potential impacts on non-toxic categories are much smaller than what is found for other fractions of municipal solid waste. Incineration (up to 35% of the garden waste) and home composting (up to 18% of the garden waste) seem from an environmental point of view suitable for diverting waste away from the composting facility in order to increase its capacity. In particular the incineration of woody parts of the garden waste improved the environmental profile of the garden waste management significantly.

  17. Trends in nanosecond melanosome microcavitation up to 1540 nm

    Science.gov (United States)

    Schmidt, Morgan S.; Kennedy, Paul K.; Noojin, Gary D.; Vincelette, Rebecca L.; Thomas, Robert J.; Rockwell, Benjamin A.

    2015-09-01

    Thresholds for microcavitation of bovine and porcine melanosomes were previously reported, using single nanosecond (ns) laser pulses in the visible (532 nm) and the near-infrared (NIR) from 1000 to 1319 nm. Here, we report average radiant exposure thresholds for bovine melanosome microcavitation at additional NIR wavelengths up to 1540 nm, which range from ˜0.159 J/cm2 at 800 nm to 4.5 J/cm2 at 1540 nm. Melanosome absorption coefficients were also estimated, and decreased with increasing wavelength. These values were compared to retinal pigment epithelium coefficients, and to water absorption, over the same wavelength range. Corneal total intraocular energy retinal damage threshold values were estimated and compared to the previous (2007) and recently changed (2014) maximum permissible exposure (MPE) safe levels. Results provide additional data that support the recent changes to the MPE levels, as well as the first microcavitation data at 1540 nm, a wavelength for which melanosome microcavitation may be an ns-pulse skin damage mechanism.

  18. Infrared laser damage thresholds in corneal tissue phantoms using femtosecond laser pulses

    Science.gov (United States)

    Boretsky, Adam R.; Clary, Joseph E.; Noojin, Gary D.; Rockwell, Benjamin A.

    2018-02-01

    Ultrafast lasers have become a fixture in many biomedical, industrial, telecommunications, and defense applications in recent years. These sources are capable of generating extremely high peak power that can cause laser-induced tissue breakdown through the formation of a plasma upon exposure. Despite the increasing prevalence of such lasers, current safety standards (ANSI Z136.1-2014) do not include maximum permissible exposure (MPE) values for the cornea with pulse durations less than one nanosecond. This study was designed to measure damage thresholds in corneal tissue phantoms in the near-infrared and mid-infrared to identify the wavelength dependence of laser damage thresholds from 1200-2500 nm. A high-energy regenerative amplifier and optical parametric amplifier outputting 100 femtosecond pulses with pulse energies up to 2 mJ were used to perform exposures and determine damage thresholds in transparent collagen gel tissue phantoms. Three-dimensional imaging, primarily optical coherence tomography, was used to evaluate tissue phantoms following exposure to determine ablation characteristics at the surface and within the bulk material. The determination of laser damage thresholds in the near-IR and mid-IR for ultrafast lasers will help to guide safety standards and establish the appropriate MPE levels for exposure sensitive ocular tissue such as the cornea. These data will help promote the safe use of ultrafast lasers for a wide range of applications.

  19. MICROS E PEQUENAS EMPRESAS NO BRASIL – UM OLHAR PARA SITUAÇÃO EM OSASCO E UMA CONTRIBUIÇÃO PARA O PROCESSO DE IMPLANTAÇÃO DO CÓDIGO DE ÉTICA

    Directory of Open Access Journals (Sweden)

    Maria Inês Zampolim Coelho

    2011-06-01

    Full Text Available The organic structure of Micro and Small Companies (MPE in Brazil is simpler than the one in medium and large companies, nevertheless they can present similar problems in its day-today, such as ethical misconduct of its administrators or owners, controllers’ or employees’ corruption, fiscal tax evasion, problems of relationships with customers and suppliers, among others conflicts. The main objective of this research is identifying the current situation of some of the smaller companies in the city of Osasco, focusing on the Code of Ethics. The research sample, made through phone calls, showed us that many of these companies do not have any code of ethics. This finding indicated the necessity for a bibliographical research and some statistical data to confirm the importance of the Ethic Code for the MPE. The results gave us the opportunity to contribute with steps for the implementation of an Ethic Code in Micro and Small companies, aiming an expansion of their market image and better competitiveness.

  20. Sensitivity of Distributed Hydrologic Simulations to Ground and Satellite Based Rainfall Products

    Directory of Open Access Journals (Sweden)

    Singaiah Chintalapudi

    2014-05-01

    Full Text Available In this study, seven precipitation products (rain gauges, NEXRAD MPE, PERSIANN 0.25 degree, PERSIANN CCS-3hr, PERSIANN CCS-1hr, TRMM 3B42V7, and CMORPH were used to force a physically-based distributed hydrologic model. The model was driven by these products to simulate the hydrologic response of a 1232 km2 watershed in the Guadalupe River basin, Texas. Storm events in 2007 were used to analyze the precipitation products. Comparison with rain gauge observations reveals that there were significant biases in the satellite rainfall products and large variations in the estimated amounts. The radar basin average precipitation compared very well with the rain gauge product while the gauge-adjusted TRMM 3B42V7 precipitation compared best with observed rainfall among all satellite precipitation products. The NEXRAD MPE simulated streamflows matched the observed ones the best yielding the highest Nash-Sutcliffe Efficiency correlation coefficient values for both the July and August 2007 events. Simulations driven by TRMM 3B42V7 matched the observed streamflow better than other satellite products for both events. The PERSIANN coarse resolution product yielded better runoff results than the higher resolution product. The study reveals that satellite rainfall products are viable alternatives when rain gauge or ground radar observations are sparse or non-existent.

  1. Using Akka Platform in Unidentified Falling Object Detection on the LHC.

    CERN Document Server

    Motesnitsalis, Evangelos

    2013-01-01

    During my participation in the CERN Summer Student Program 2013, I worked under the Technology Department of CERN and, more specifically, in the Machine Protection and Electrical Integrity (MPE) Group. The MPE Group supports LHC operation and maintains state‐of‐the art technology for magnet circuit protection and interlock systems for the present and future accelerators, magnet test facilities and CERN hosted experiments. Within this context, we developed an application that parallelizes the Unidentified Falling Object Detection Algorithm on the LHC Operational Data Analysis Software. For this reason, we used a JVM-based toolkit, named Akka, which parallelizes the execution by creating a number of actors that run simultaneously. The results of the new approach are presented on the last part of this report. They tend to be quite interesting and promising as we managed to reduce the execution time of the analysis by a factor of 10 on a local machine and the first attempts to execute the program on a cluster...

  2. On the Latent Variable Interpretation in Sum-Product Networks.

    Science.gov (United States)

    Peharz, Robert; Gens, Robert; Pernkopf, Franz; Domingos, Pedro

    2017-10-01

    One of the central themes in Sum-Product networks (SPNs) is the interpretation of sum nodes as marginalized latent variables (LVs). This interpretation yields an increased syntactic or semantic structure, allows the application of the EM algorithm and to efficiently perform MPE inference. In literature, the LV interpretation was justified by explicitly introducing the indicator variables corresponding to the LVs' states. However, as pointed out in this paper, this approach is in conflict with the completeness condition in SPNs and does not fully specify the probabilistic model. We propose a remedy for this problem by modifying the original approach for introducing the LVs, which we call SPN augmentation. We discuss conditional independencies in augmented SPNs, formally establish the probabilistic interpretation of the sum-weights and give an interpretation of augmented SPNs as Bayesian networks. Based on these results, we find a sound derivation of the EM algorithm for SPNs. Furthermore, the Viterbi-style algorithm for MPE proposed in literature was never proven to be correct. We show that this is indeed a correct algorithm, when applied to selective SPNs, and in particular when applied to augmented SPNs. Our theoretical results are confirmed in experiments on synthetic data and 103 real-world datasets.

  3. Elections for representatives of the personnel – Join, get involved, vote!

    CERN Multimedia

    Staff Association

    2017-01-01

    Every two years in September, the CERN Staff Association organises the elections of representatives of the personnel. The process of renewing the Staff Council consists of several stages: Information for members of the personnel (MPE and MPA1); call for applications and search for candidates in different electoral colleges; election of delegates via electronic voting; announcement of the results and establishing a new Staff Council. This process will follow a specific timetable: Call for applications from Monday, 11 September to Friday, 13 October at 5 p.m. Voting from Monday, 23 October at noon to Monday 13, November at 5 p.m. Publication of the election results in the Echo newsletter on Tuesdays 21 November and 5 December. Staff Association Assizes (for the outgoing Council and the new Council) on Monday, 27 and Tuesday, 28 November. First meeting of the new Staff Council and election of a new Executive Committee on Tuesday, 5 December. Informing the personnel (MPE and MPA) The Staff Association uses s...

  4. Valuación de opciones simples y complejas contenidas en arrendamientos financieros

    Directory of Open Access Journals (Sweden)

    Gastón Silverio Milanesi

    2016-01-01

    Full Text Available El valor de los contratos de arrendamiento es una función del valor presente de los cánones más las opciones reales operativas. Sin embargo, el método del préstamo equivalente (MPE, con amplia aplicación en la valuación de arrendamientos, falla porque no incorpora las opciones contenidas en el contrato. De esta forma, el presente trabajo propone un modelo de valuación combinando el MPE y el enfoque binomial para valuar opciones reales. Para lograr lo anterior, se realiza el planteamiento matemático y su aplicación para opciones simples (compra, cancelación anticipada, renovación y compuestas (venture leasing, leasing a porcentaje, pago diferido, pago diferido y compra, demostrando la habilidad del modelo para calcular el valor actual expandido del contrato, como la suma del valor actual de pagos y opciones operativas.

  5. HPLC Evaluation of Phenolic Profile, Nutritive Content, and Antioxidant Capacity of Extracts Obtained from Punica granatum Fruit Peel

    Science.gov (United States)

    Middha, Sushil Kumar; Usha, Talambedu; Pande, Veena

    2013-01-01

    This study revealed polyphenolic content, nutritive content, antioxidant activity, and phenolic profile of methanol and aqueous extracts of Punica granatum peel extract. For this, extracts were screened for possible antioxidant activities by free radical scavenging activity (DPPH), hydrogen peroxide scavenging activity and ferric-reducing antioxidant power (FRAP) assays. The total phenolics and flavonoid recovered by methanolic (MPE) and the water extract (AQPE) were ranged from 185 ± 12.45 to 298.00 ± 24.86 mg GAE (gallic acid equivalents)/gm and 23.05 ± 1.54 to 49.8 ± 2.14 quercetin (QE) mg/g, respectively. The EC50 of herbal extracts ranged from 100 µg/ml (0.38 quercetin equivalents), for AQPE, 168 µg/ml (0.80 quercetin equivalents), for MPE. The phenolic profile in the methanolic extracts was investigated by chromatographic (HPLC) method. About 5 different flavonoids, phenolic acids, and their derivatives including quercetin (1), rutin (2), gallic acid (3), ellagic acid (4), and punicalagin as a major ellagitannin (5) have been identified. Among both extracts, methanolic extract was the most effective. This report may be the first to show nutritive content and correlation analysis to suggest that phenols and flavonoids might contribute the high antioxidant activity of this fruit peel and establish it as a valuable natural antioxidant source applicable in the health food industry. PMID:23983682

  6. Objective Function and Learning Algorithm for the General Node Fault Situation.

    Science.gov (United States)

    Xiao, Yi; Feng, Rui-Bin; Leung, Chi-Sing; Sum, John

    2016-04-01

    Fault tolerance is one interesting property of artificial neural networks. However, the existing fault models are able to describe limited node fault situations only, such as stuck-at-zero and stuck-at-one. There is no general model that is able to describe a large class of node fault situations. This paper studies the performance of faulty radial basis function (RBF) networks for the general node fault situation. We first propose a general node fault model that is able to describe a large class of node fault situations, such as stuck-at-zero, stuck-at-one, and the stuck-at level being with arbitrary distribution. Afterward, we derive an expression to describe the performance of faulty RBF networks. An objective function is then identified from the formula. With the objective function, a training algorithm for the general node situation is developed. Finally, a mean prediction error (MPE) formula that is able to estimate the test set error of faulty networks is derived. The application of the MPE formula in the selection of basis width is elucidated. Simulation experiments are then performed to demonstrate the effectiveness of the proposed method.

  7. Chronic alcohol drinking: Liver and pancreatic cancer?

    Science.gov (United States)

    Zakhari, Samir

    2015-09-01

    Cancer is a multifactorial disease that results from complex interactions of numerous risk factors - genetic and environmental - over time, eventually leading to the diseased phenotypes. Thus, while epidemiological studies can point to risk factors, they cannot determine cause and effect relationships, and are unable to give biological and clinical insights into carcinogenesis. The link between any risk factor and carcinogenesis needs to be validated in experimental models. This is particularly true in epidemiological studies on alcohol consumption and its consequences. While there is no doubt that heavy alcohol consumption has devastating health effects, the inconsistencies in alcohol-related epidemiological studies and cancer suffer from possible sources of the variability in outcomes, ranging from inaccuracy of self-report of consumption to the problem of correlating cancer that started decades earlier to current or recent alcohol consumption. To further study the interactions between alcohol and cancer, the use of "Molecular Pathological Epidemiology" (MPE) advocated by Ogino et al. for dissecting the interplay between etiological factors, cellular and molecular characteristics, and disease progression in cancer is appropriate. MPE does not consider cancer as a single entity, rather it integrates analyses of epidemiological studies with the macroenvironment and molecular and microenvironment. This approach allows investigating the relationships between potential etiological agents and cancer based on molecular signatures. More research is needed to fully elucidate the link between heavy alcohol consumption and pancreatic cancer, and to further investigate the roles of acetaldehyde and FAEEs in pancreatic carcinogenesis. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  8. SMEs’ Organizational Performance: Comparative Study between Cooperated and Uncooperated Companies

    Directory of Open Access Journals (Sweden)

    Ana Karla de Lucena Justino Gomes

    2017-12-01

    Full Text Available Faced with the need for survival and competitiveness, here called micro and small enterprises (MPE, they seek to develop competitive differentials, such as the insertion of the company into a cooperation network. Several researches seek to identify the benefits of cooperative strategies, but few studies seek to compare the organizational performance of cooperating companies with that of uncooperated companies. Thus, the present study has as general objective to verify if the MPE, when inserted in cooperation networks, present organizational performance superior to those that are not inserted in that context. The present research is of the survey type and involves 67 companies inserted in cooperation networks and 154 companies that do not participate in cooperation networks. To achieve the objective, the organizational performance was analyzed based on the managers' perception regarding aspects associated to the following performance measures: customer satisfaction, employee satisfaction, company growth, company profitability and overall performance. The results indicate that the companies included in cooperation networks presented superior performance when compared to the companies not included in cooperation networks

  9. A Comparative Study of Three Different Chemical Vapor Deposition Techniques of Carbon Nanotube Growth on Diamond Films

    Directory of Open Access Journals (Sweden)

    Betty T. Quinton

    2013-01-01

    Full Text Available This paper compares between the methods of growing carbon nanotubes (CNTs on diamond substrates and evaluates the quality of the CNTs and the interfacial strength. One potential application for these materials is a heat sink/spreader for high-power electronic devices. The CNTs and diamond substrates have a significantly higher specific thermal conductivity than traditional heat sink/spreader materials making them good replacement candidates. Only limited research has been performed on these CNT/diamond structures and their suitability of different growth methods. This study investigates three potential chemical vapor deposition (CVD techniques for growing CNTs on diamond: thermal CVD (T-CVD, microwave plasma-enhanced CVD (MPE-CVD, and floating catalyst thermal CVD (FCT-CVD. Scanning electron microscopy (SEM and high-resolution transmission electron microscopy (TEM were used to analyze the morphology and topology of the CNTs. Raman spectroscopy was used to assess the quality of the CNTs by determining the ID/IG peak intensity ratios. Additionally, the CNT/diamond samples were sonicated for qualitative comparisons of the durability of the CNT forests. T-CVD provided the largest diameter tubes, with catalysts residing mainly at the CNT/diamond interface. The MPE-CVD process yielded non uniform defective CNTs, and FCT-CVD resulted in the smallest diameter CNTs with catalyst particles imbedded throughout the length of the nanotubes.

  10. High IL-35 pleural expression in patients with tuberculous pleural effusion.

    Science.gov (United States)

    Dong, Xuan; Yang, Jiong

    2015-05-03

    IL-35 is a novel anti-inflammatory and immunosuppressive cytokine primarily produced by Treg cells, and is involved in inflammatory diseases and autoimmune diseases. However, its roles in tuberculous pleural effusion (TPE) remain unknown. We aimed to investigate the potential involvement of IL-35 in TPE. Thirty TPE patients and 20 lung cancer patients with malignant pleural effusion (MPE) were recruited. Samples of pleural effusion (100 mL) were collected after traditional pleurocentesis. Blood was sampled from TPE patients. Mononuclear cells were isolated by Ficoll-Hypaque gradient. Proportions of Th1, Th17, and IL-35-producing cells were analyzed by flow cytometry. IL-35 was assessed by real-time RT-PCR, ELISA, and immunofluorescence. An ELISPOT assay was used to assess the effect of IL-35 on pleural effusion mononuclear cells (PEMCs). Proportions of IL-35-producing cells were higher in TPE compared with MPE (49.4±6.0 vs. 15.8±5.4%, Ppleural tissues from TPE patients. Results suggest that there is an imbalance in IL-35 metabolism in TPE. However, further studies are required to assess the exact relationship with the immune system response to tuberculosis. IL-35 might play a role in TPE and might be targeted as a treatment for TPE.

  11. Malignant pleural effusion from papillary thyroid carcinoma diagnosed by pleural effusion cytology: A case report.

    Science.gov (United States)

    Kosmas, Konstantinos; Tsonou, Anna; Mitropoulou, Georgia; Salemi, Eufrosyni; Kazi, Danai; Theofanopoulou, Ageliki

    2018-02-01

    Papillary thyroid carcinoma (PTC) is by far the most common thyroid malignancy (over 85%) of all the thyroid cancers. It has excellent prognosis and 10-year survival rate in most of the cases (95%). Most of the tumors are indolent and do not recur or metastasize after removal. However, widespread metastases to lung, skeleton, central nervous system and, occasionally, other organs may be observed. In rare instances, this disease may metastasize to the pleura and manifest as a malignant pleural effusion (MPE) and portend poor prognosis. This article reports the cytomorphologic and immunocytochemical findings of a female patient with a symptomatic pleural effusion resulting from PTC metastatic to the pleura. Pleural fluid cytology revealed abundant papillary clusters with relatively nuclear pleomorphism, intranuclear cytoplasmic inclusions and nuclear grooves, small and distinct nucleoli as well as small discrete vacuoles. Psammoma bodies were not seen. Immunocytochemical staining was positive for TGB, EMA, Ber-EP4, CK19, and negative for TTF-1. Metastasis of PTC to pleural fluid is extremely rare and diagnosing the disease by cytology is challenging and requires medical expertise as well as knowledge of clinical context and immunocytochemical staining. Additionally, a cytologic diagnosis of MPE due to PTC provides important treatment information and plays an important role in prognosis. © 2017 Wiley Periodicals, Inc.

  12. Light Dawns on Dark Gamma-ray Bursts

    Science.gov (United States)

    2010-12-01

    journal Astronomy & Astrophysics on 16 December 2010 The team is composed of: J. Greiner (Max-Planck-Institut für extraterrestrische Physik [MPE], Germany), T. Krühler (MPE, Universe Cluster, Technische Universität München), S. Klose (Thüringer Landessternwarte, Germany), P. Afonso (MPE), C. Clemens (MPE), R. Filgas (MPE), D.H. Hartmann (Clemson University, USA), A. Küpcü Yoldaş¸ (University of Cambridge, UK), M. Nardini (MPE), F. Olivares E. (MPE), A. Rau (MPE), A. Rossi (Thüringer Landessternwarte, Germany), P. Schady (MPE), and A. Updike (Clemson University, USA) ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 14 countries: Austria, Belgium, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory and VISTA, the world's largest survey telescope. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a 42-metre European Extremely Large optical/near-infrared Telescope, the E-ELT, which will become "the world's biggest eye on the sky".

  13. Comparative Study of the Gross Interpretation of Phototesting and Objective Measurement with Using a Spectrophotometer for Patients with Psoriasis and Vitiligo Treated with Narrow-band UVB.

    Science.gov (United States)

    Choi, Kyu-Won; Kim, Ki-Ho; Kim, Young-Hun

    2009-05-01

    Determination of the minimal erythema dose (MED) is important for developing a phototherapy protocol and to diagnosis photosensitivity disorders. But obtaining a precise and reproducible MED is quite difficult because a phototest for erythema is based on subjective assessment. The objective of our study was to compare the gross interpretation of a phototest and the objective measurement using a spectrophotometer for determining the parameters of cutaneous narrow-band UVB (NBUVB) therapy. A total of 14 psoriasis and 10 vitiligo patients who receiving NBUVB phototherapy with skin types III and IV were selected for this study. To perform phototesting, ten sites on the skin of the back were vertically exposed to a series of 10 NBUVB doses among 14 doses between 340 and 1,400 mJ/cm(2). We interpreted the gross findings of erythema and measured the L*a*b* values with using a spectrophotometer at each phototest spot and at the control skin. Also, we evaluate the relationship between the gross presentation and the spectrophotometric analysis by delta E for the assessment of the minimal perceptible erythema (MPE) and MED. For all the subjects, the MEDs were measured in the 490~1,000 mJ/cm(2) range. The average of the colorimetric values for the control skin were L*: 64.8, a*: 7.9 and b*: 19.8. Among them, the L* value and MED value were shown to be inversely correlated, and as the L* value was decreased, the MED was increased. For the MPE, the delta E, which was the color difference of the normal skin and the phototest area, was within the range of 1.5~3.0 in 17 of the 21 patients, and 4 patients were within the range of 1.0~1.5. For the MED, among the 21 patients, the delta E of 17 patients was within the range of 3.0~6.0, and 4 patients were within the range of 6.0~12.0. A spectrophotometer enables UV erythema to be assessed objectively and quantitatively, and this can compensate for the disadvantages of subjective gross interpretation when determining the MED. Delta E is

  14. A maximum pseudo-likelihood approach for estimating species trees under the coalescent model

    Directory of Open Access Journals (Sweden)

    Edwards Scott V

    2010-10-01

    Full Text Available Abstract Background Several phylogenetic approaches have been developed to estimate species trees from collections of gene trees. However, maximum likelihood approaches for estimating species trees under the coalescent model are limited. Although the likelihood of a species tree under the multispecies coalescent model has already been derived by Rannala and Yang, it can be shown that the maximum likelihood estimate (MLE of the species tree (topology, branch lengths, and population sizes from gene trees under this formula does not exist. In this paper, we develop a pseudo-likelihood function of the species tree to obtain maximum pseudo-likelihood estimates (MPE of species trees, with branch lengths of the species tree in coalescent units. Results We show that the MPE of the species tree is statistically consistent as the number M of genes goes to infinity. In addition, the probability that the MPE of the species tree matches the true species tree converges to 1 at rate O(M -1. The simulation results confirm that the maximum pseudo-likelihood approach is statistically consistent even when the species tree is in the anomaly zone. We applied our method, Maximum Pseudo-likelihood for Estimating Species Trees (MP-EST to a mammal dataset. The four major clades found in the MP-EST tree are consistent with those in the Bayesian concatenation tree. The bootstrap supports for the species tree estimated by the MP-EST method are more reasonable than the posterior probability supports given by the Bayesian concatenation method in reflecting the level of uncertainty in gene trees and controversies over the relationship of four major groups of placental mammals. Conclusions MP-EST can consistently estimate the topology and branch lengths (in coalescent units of the species tree. Although the pseudo-likelihood is derived from coalescent theory, and assumes no gene flow or horizontal gene transfer (HGT, the MP-EST method is robust to a small amount of HGT in the

  15. Radiation protection in dental X-ray surgeries--still rooms for improvement.

    Science.gov (United States)

    Hart, G; Dugdale, M

    2013-03-01

    To illustrate the authors' experience in the provision of radiation protection adviser (RPA)/medical physics expert (MPE) services and critical examination/radiation quality assurance (QA) testing, to demonstrate any continuing variability of the compliance of X-ray sets with existing guidance and of compliance of dental practices with existing legislation. Data was collected from a series of critical examination and routine three-yearly radiation QA tests on 915 intra-oral X-ray sets and 124 panoramic sets. Data are the result of direct measurements on the sets, made using a traceably calibrated Unfors Xi meter. The testing covered the measurement of peak kilovoltage (kVp); filtration; timer accuracy and consistency; X-ray beam size; and radiation output, measured as the entrance surface dose in milliGray (mGy) for intra-oral sets and dose-area product (DAP), measured in mGy.cm(2) for panoramic sets. Physical checks, including mechanical stability, were also included as part of the testing process. The Health and Safety Executive has expressed concern about the poor standards of compliance with the regulations during inspections at dental practices. Thirty-five percent of intra-oral sets exceeded the UK adult diagnostic reference level on at least one setting, as did 61% of those with child dose settings. There is a clear advantage of digital radiography and rectangular collimation in dose terms, with the mean dose from digital sets 59% that of film-based sets and a rectangular collimator 76% that of circular collimators. The data shows the unrealised potential for dose saving in many digital sets and also marked differences in dose between sets. Provision of radiation protection advice to over 150 general dental practitioners raised a number of issues on the design of surgeries with X-ray equipment and critical examination testing. There is also considerable variation in advice given on the need (or lack of need) for room shielding. Where no radiation protection

  16. Summary of: radiation protection in dental X-ray surgeries--still rooms for improvement.

    Science.gov (United States)

    Walker, Anne

    2013-03-01

    To illustrate the authors' experience in the provision of radiation protection adviser (RPA)/medical physics expert (MPE) services and critical examination/radiation quality assurance (QA) testing, to demonstrate any continuing variability of the compliance of X-ray sets with existing guidance and of compliance of dental practices with existing legislation. Data was collected from a series of critical examination and routine three-yearly radiation QA tests on 915 intra-oral X-ray sets and 124 panoramic sets. Data are the result of direct measurements on the sets, made using a traceably calibrated Unfors Xi meter. The testing covered the measurement of peak kilovoltage (kVp); filtration; timer accuracy and consistency; X-ray beam size; and radiation output, measured as the entrance surface dose in milliGray (mGy) for intra-oral sets and dose-area product (DAP), measured in mGy.cm(2) for panoramic sets. Physical checks, including mechanical stability, were also included as part of the testing process. The Health and Safety Executive has expressed concern about the poor standards of compliance with the regulations during inspections at dental practices. Thirty-five percent of intra-oral sets exceeded the UK adult diagnostic reference level on at least one setting, as did 61% of those with child dose settings. There is a clear advantage of digital radiography and rectangular collimation in dose terms, with the mean dose from digital sets 59% that of film-based sets and a rectangular collimator 76% that of circular collimators. The data shows the unrealised potential for dose saving in many digital sets and also marked differences in dose between sets. Provision of radiation protection advice to over 150 general dental practitioners raised a number of issues on the design of surgeries with X-ray equipment and critical examination testing. There is also considerable variation in advice given on the need (or lack of need) for room shielding. Where no radiation protection

  17. Pathways of Prion Spread during Early Chronic Wasting Disease in Deer.

    Science.gov (United States)

    Hoover, Clare E; Davenport, Kristen A; Henderson, Davin M; Denkers, Nathaniel D; Mathiason, Candace K; Soto, Claudio; Zabel, Mark D; Hoover, Edward A

    2017-05-15

    Among prion infections, two scenarios of prion spread are generally observed: (i) early lymphoid tissue replication or (ii) direct neuroinvasion without substantial antecedent lymphoid amplification. In nature, cervids are infected with chronic wasting disease (CWD) prions by oral and nasal mucosal exposure, and studies of early CWD pathogenesis have implicated pharyngeal lymphoid tissue as the earliest sites of prion accumulation. However, knowledge of chronological events in prion spread during early infection remains incomplete. To investigate this knowledge gap in early CWD pathogenesis, we exposed white-tailed deer to CWD prions by mucosal routes and performed serial necropsies to assess PrP CWD tissue distribution by real-time quaking-induced conversion (RT-QuIC) and tyramide signal amplification immunohistochemistry (TSA-IHC). Although PrP CWD was not detected by either method in the initial days (1 and 3) postexposure, we observed PrP CWD seeding activity and follicular immunoreactivity in oropharyngeal lymphoid tissues at 1 and 2 months postexposure (MPE). At 3 MPE, PrP CWD replication had expanded to all systemic lymphoid tissues. By 4 MPE, the PrP CWD burden in all lymphoid tissues had increased and approached levels observed in terminal disease, yet there was no evidence of nervous system invasion. These results indicate the first site of CWD prion entry is in the oropharynx, and the initial phase of prion amplification occurs in the oropharyngeal lymphoid tissues followed by rapid dissemination to systemic lymphoid tissues. This lymphoid replication phase appears to precede neuroinvasion. IMPORTANCE Chronic wasting disease (CWD) is a universally fatal transmissible spongiform encephalopathy affecting cervids, and natural infection occurs through oral and nasal mucosal exposure to infectious prions. Terminal disease is characterized by PrP CWD accumulation in the brain and lymphoid tissues of affected animals. However, the initial sites of prion

  18. Multiscale Persistent Functions for Biomolecular Structure Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Xia, Kelin [Nanyang Technological University (Singapore). Division of Mathematical Sciences, School of Physical, Mathematical Sciences and School of Biological Sciences; Li, Zhiming [Central China Normal University, Wuhan (China). Key Laboratory of Quark and Lepton Physics (MOE) and Institute of Particle Physics; Mu, Lin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Computer Science and Mathematics Division

    2017-11-02

    Here in this paper, we introduce multiscale persistent functions for biomolecular structure characterization. The essential idea is to combine our multiscale rigidity functions (MRFs) with persistent homology analysis, so as to construct a series of multiscale persistent functions, particularly multiscale persistent entropies, for structure characterization. To clarify the fundamental idea of our method, the multiscale persistent entropy (MPE) model is discussed in great detail. Mathematically, unlike the previous persistent entropy (Chintakunta et al. in Pattern Recognit 48(2):391–401, 2015; Merelli et al. in Entropy 17(10):6872–6892, 2015; Rucco et al. in: Proceedings of ECCS 2014, Springer, pp 117–128, 2016), a special resolution parameter is incorporated into our model. Various scales can be achieved by tuning its value. Physically, our MPE can be used in conformational entropy evaluation. More specifically, it is found that our method incorporates in it a natural classification scheme. This is achieved through a density filtration of an MRF built from angular distributions. To further validate our model, a systematical comparison with the traditional entropy evaluation model is done. Additionally, it is found that our model is able to preserve the intrinsic topological features of biomolecular data much better than traditional approaches, particularly for resolutions in the intermediate range. Moreover, by comparing with traditional entropies from various grid sizes, bond angle-based methods and a persistent homology-based support vector machine method (Cang et al. in Mol Based Math Biol 3:140–162, 2015), we find that our MPE method gives the best results in terms of average true positive rate in a classic protein structure classification test. More interestingly, all-alpha and all-beta protein classes can be clearly separated from each other with zero error only in our model. Finally, a special protein structure index (PSI) is proposed, for the first

  19. Prediction of beef carcass and meat traits from rearing factors in young bulls and cull cows.

    Science.gov (United States)

    Soulat, J; Picard, B; Léger, S; Monteils, V

    2016-04-01

    The aim of this study was to predict the beef carcass and LM (thoracis part) characteristics and the sensory properties of the LM from rearing factors applied during the fattening period. Individual data from 995 animals (688 young bulls and 307 cull cows) in 15 experiments were used to establish prediction models. The data concerned rearing factors (13 variables), carcass characteristics (5 variables), LM characteristics (2 variables), and LM sensory properties (3 variables). In this study, 8 prediction models were established: dressing percentage and the proportions of fat tissue and muscle in the carcass to characterize the beef carcass; cross-sectional area of fibers (mean fiber area) and isocitrate dehydrogenase activity to characterize the LM; and, finally, overall tenderness, juiciness, and flavor intensity scores to characterize the LM sensory properties. A random effect was considered in each model: the breed for the prediction models for the carcass and LM characteristics and the trained taste panel for the prediction of the meat sensory properties. To evaluate the quality of prediction models, 3 criteria were measured: robustness, accuracy, and precision. The model was robust when the root mean square errors of prediction of calibration and validation sub-data sets were near to one another. Except for the mean fiber area model, the obtained predicted models were robust. The prediction models were considered to have a high accuracy when the mean prediction error (MPE) was ≤0.10 and to have a high precision when the was the closest to 1. The prediction of the characteristics of the carcass from the rearing factors had a high precision ( > 0.70) and a high prediction accuracy (MPE 0.10). Only the flavor intensity of the beef score could be satisfactorily predicted from the rearing factors with high precision ( = 0.72) and accuracy (MPE = 0.10). All the prediction models displayed different effects of the rearing factors according to animal categories

  20. Co-administration of morphine and gabapentin leads to dose dependent synergistic effects in a rat model of postoperative pain

    DEFF Research Database (Denmark)

    Papathanasiou, Theodoros; Juul, Rasmus Vestergaard; Heegaard, Anne-Marie

    2016-01-01

    dose combinations and investigate whether co-administration leads to synergistic effects in a preclinical model of postoperative pain. The pharmacodynamic effects of morphine (1, 3 and 7 mg/kg), gabapentin (10, 30 and 100 mg/kg) or their combination (9 combinations in total) were evaluated in the rat...... plantar incision model using an electronic von Frey device. The percentage of maximum possible effect (%MPE) and the area under the response curve (AUC) were used for evaluation of the antihyperalgesic effects of the drugs. Identification of synergistic interactions was based on Loewe additivity response...... surface analyses. The combination of morphine and gabapentin resulted in synergistic antihyperalgesic effects in a preclinical model of postoperative pain. The synergistic interactions were found to be dose dependent and the increase in observed response compared to the theoretical additive response...

  1. Marketing practitioner’s tacit knowledge acquisition using Repertory Grid Technique (RTG)

    Science.gov (United States)

    Azmi, Afdhal; Adriman, Ramzi

    2018-05-01

    The tacit knowledge of Marketing practitioner’s experts is excellent resources and priceless. It takes into account their experiential, skill, ideas, belief systems, insight and speculation into management decision-making. This expertise is an individual intuitive judgment and personal shortcuts to complete the work efficiently. Tacit knowledge of Marketing practitioner’s experts is one of best problem solutions in marketing strategy, environmental analysis, product management and partner’s relationship. This paper proposes the acquisition method of tacit knowledge from Marketing practitioner’s using Repertory Grid Technique (RGT). The RGT is a software application for tacit acquisition knowledge to provide a systematic approach to capture and acquire the constructs from an individual. The result shows the understanding of RGT could make TKE and MPE get a good result in capturing and acquiring tacit knowledge of Marketing practitioner’s experts.

  2. The X-ray Telescope for the SWIFT Gamma-Ray Burst Mission

    International Nuclear Information System (INIS)

    Wells, A.; Abbey, A.F.; Beardmore, A.; Mukerjee, K.; Osborne, J.P.; Watson, D.J.; Willingale, R.; Burrows, D. N.; Hill, J. E.; Nousek, J.A.; Miles, B.J.; Mori, K.; Morris, D.C.; Zugger, M.; Chincarini, G.; Campana, S.; Citterio, O.; Moretti, A.; Tagliaferri, G.; Bosworth, J.

    2004-01-01

    The X-ray Telescope (XRT) for the SWIFT mission, built by the international consortium from Pennsylvania State University (United States), University of Leicester (UK) and Osservatorio Astronomico di Brera (Italy), is already installed on the SWIFT spacecraft. The XRT has two key functions on SWIFT; to determine locations of GRBs to better than 5 arc seconds within 100 seconds of initial detection of a burst and to measure spectra and light curves of the X-ray afterglow over around four orders of magnitude of decay in the afterglow intensity. This paper summarises the XRT performance, operating modes and sensitivity for the detection of prompt and extended X-ray afterglows from gamma-ray bursts. The performance characteristics have been determined from data taken during the ground calibration campaign at MPE's Panter facility in September 2002

  3. Uma reflexão sobre a qualificação na formação em turismo: relevancia da micro e pequena empresa para o destino turístico

    OpenAIRE

    Thiago Duarte Pimentel; Sara Conceição de Paula; Marcela Costa Bifano de Oliveira

    2016-01-01

    Este artigo visa identificar os principais desafíos e tendências de qualificação e formação do turismólogo, bem como sua inserção profissional no contexto de um destino turístico (DT) majoritariamente formado por Micro e Pequenas Empresas (MPE’S). Com base na literatura especializada sobre MPE e sobre qualificação profissional em turismo, realizou-se uma pesquisa quali-quantitativa de cunho exploratório aplicado aos responsáveis pela contratação das organizações ligadas às Atividades Caracter...

  4. Approaches in setting up a system for certification of the Medical Physicists in some European Countries - possibilities for application in Bulgaria

    International Nuclear Information System (INIS)

    Dimov, A.; Slavchev, A.; Tabakov, S.; Stoeva, M.; Lichev, A.

    2004-01-01

    In Europe there are different approaches for harmonization with the Medical Exposure Directive (MED) and the EFOMP recommendations concerning the medical physicists' certification. The two most appropriate types are: 1) Based on folder with evidences and 2) Based on continuous professional development (CPD) evidences assessed by credit points system. An example for certification type 1 is the Radiation Protection Advisers (RPA) certification made by RPA2000 in the UK, which is described in the report. The experience of the Netherlands, Germany, Switzerland, Austria and Belgium are also presented. The situation in Bulgaria is analysed and proposal for further improvement and harmonization with the EC and EFOMP are given. A conclusion is made efforts should be done for establishing of modern accreditation and registration scheme of the MP and MPE in Bulgaria. In Bulgaria there is an urgent need for education, training and official certification of new specialists in this field

  5. "De vil os stadig til livs"

    DEFF Research Database (Denmark)

    Nielsen, Asta Smedegaard

    Med udgangspunkt i et perspektiv på terrortruslen mod Danmark som et diskursivt og oplevet fænomen udforskes de betydningskonstruktioner, der skabes i public service-medierne DR1 og TV2’s tv-nyhedsformidling om truslen, med særligt fokus på konstruktioner af racial, national og etnisk enshed og f...... bestræbelserne til at forstå og bekæmpe terrortruslen. Afhandlingen lægger vægt på betydningen af ’race’ i disse betydningskonstruktioner, idet analyserne peger på, at Breiviks hvidhed havde væsentlig betydning for den individualisering, der skete af ham og hans terror....

  6. Topology optimum design of compliant mechanisms using modified ant colony optimization

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Kwang Seon; Han, Seog Young [Hanyang University, Seoul (Korea, Republic of)

    2015-08-15

    A Modified ant colony optimization (MACO) algorithm was suggested for topology optimal design of compliant mechanisms since standard ACO cannot provide an appropriate optimal topology. In order to improve computational efficiency and suitability of standard ACO algorithm in topology optimization for compliant mechanisms, a continuous variable, called the 'Element contribution significance (ECS),'is employed, which serves to replace the positions of ants in the standard ACO algorithm, and assess the importance of each element in the optimization process. MACO algorithm was applied to topology optimizations of both linear and geometrically nonlinear compliant mechanisms using three kinds of objective functions, and optimized topologies were compared each other. From the comparisons, it was concluded that MACO algorithm can effectively be applied to topology optimizations of linear and geometrically nonlinear compliant mechanisms, and the ratio of Mutual potential energy (MPE) to Strain energy (SE) type of objective function is the best for topology optimal design of compliant mechanisms.

  7. Aerodynamic findings and Voice Handicap Index in Parkinson's disease.

    Science.gov (United States)

    Motta, Sergio; Cesari, Ugo; Paternoster, Mariano; Motta, Giovanni; Orefice, Giuseppe

    2018-04-23

    To verify possible relations between vocal disability and aerodynamic measures in selected Parkinson's disease (PD) patients with low/moderate-grade dysphonia. Fifteen idiopathic dysphonic PD male patients were examined and compared with 15 euphonic subjects. Testing included the following measures: Voice Handicap Index (VHI), maximum phonation time (MPT), mean estimated subglottal pressure (MESGP), mean sound pressure level (MSPL), mean phonatory power (MPP), mean phonatory efficiency (MPE) and mean phonatory resistance (MPR). Statistical analysis showed: a significant reduction in MPR and MSPL in PD subjects compared to the healthy ones; a significant positive correlation between VHI score and MSPL, MPR, MPP, MESGP and a significant negative correlation between VHI and MTP within PD subjects. Test for multiple linear regression showed a significant correlation between VHI score, MPT, MPR and MSPL. A relationship between VHI and aerodynamic measures was shown in the present study. Compensatory mechanisms may aggravate vocal disability in PD subjects.

  8. Mathematical paradigms of climate science

    CERN Document Server

    Cannarsa, Piermarco; Jones, Christopher; Portaluri, Alessandro

    2016-01-01

    This book, featuring a truly interdisciplinary approach, provides an overview of cutting-edge mathematical theories and techniques that promise to play a central role in climate science. It brings together some of the most interesting overview lectures given by the invited speakers at an important workshop held in Rome in 2013 as a part of MPE2013 (“Mathematics of Planet Earth 2013”). The aim of the workshop was to foster the interaction between climate scientists and mathematicians active in various fields linked to climate sciences, such as dynamical systems, partial differential equations, control theory, stochastic systems, and numerical analysis. Mathematics and statistics already play a central role in this area. Likewise, computer science must have a say in the efforts to simulate the Earth’s environment on the unprecedented scale of petabytes. In the context of such complexity, new mathematical tools are needed to organize and simplify the approach. The growing importance of data assimilation te...

  9. Neural networks applied to characterize blends containing refined and extra virgin olive oils.

    Science.gov (United States)

    Aroca-Santos, Regina; Cancilla, John C; Pariente, Enrique S; Torrecilla, José S

    2016-12-01

    The identification and quantification of binary blends of refined olive oil with four different extra virgin olive oil (EVOO) varietals (Picual, Cornicabra, Hojiblanca and Arbequina) was carried out with a simple method based on combining visible spectroscopy and non-linear artificial neural networks (ANNs). The data obtained from the spectroscopic analysis was treated and prepared to be used as independent variables for a multilayer perceptron (MLP) model. The model was able to perfectly classify the EVOO varietal (100% identification rate), whereas the error for the quantification of EVOO in the mixtures containing between 0% and 20% of refined olive oil, in terms of the mean prediction error (MPE), was 2.14%. These results turn visible spectroscopy and MLP models into a trustworthy, user-friendly, low-cost technique which can be implemented on-line to characterize olive oil mixtures containing refined olive oil and EVOOs. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Evaluation of Applicability of Global Solar Radiation Prediction Models for Kocaeli

    Directory of Open Access Journals (Sweden)

    Nurullah ARSLANOĞLU

    2016-04-01

    Full Text Available Design and analyses of solar energy systems needs value of global solar radiation falling on the surface of the earth. In this study,  thirty relative sunshine duration based regression models in the literature for determining the monthly average daily global solar radiation on a horizontal surface for Kocaeli were investigated. To indicate the performance of the models, the following statistical test methods are used: mean absolute bias error (MABE, mean bias error (MBE, mean absolute percent error (MAPE, mean percent error (MPE, root mean square error (RMSE. According to the statistical performance, Lewis model (Model 23, Model-18 (Jin et al. and Model 8 (Bahel et al. showed the best estimation of the global solar radiation on a horizontal surface for Kocaeli.

  11. Remembering and Telling: Narrative Coherence and Phenomenal Aspects of Autobiographical Memories

    Directory of Open Access Journals (Sweden)

    Gustavo Gauer

    2010-01-01

    Full Text Available Investigated the relationship between phenomenal qualities of autobiographical memories and narrative structure of written reports of them. In Experiment 1, 30 undergraduates provided 2 reports, the most momentous event of their lives (MPE and their earliest childhood recollection (ECR. Reports were coded for 2 variables: narrative coherence (NC, and event specificity (SP. No significant relationship was found between NC and SP, nor between SP and type of event. Experiment 2 asked 40 undergraduates to report MPEs and correlated NC and subjective ratings of events from the Autobiographical Memory Questionnaire (AMQ: vividness of imagery, recollection, importance, consequences, and rehearsal. A significant correlation between importance rating and the orientation index points out to the flashbulb aspect of the memories. Significant correlation between volume report and recollection indicates an interaction between higher indices of recollection and individual's predisposition to report the event in written form. Results did not corroborate a hypothesis of identity between autobiographical memory representation and expression.

  12. Experimental approach for the uncertainty assessment of 3D complex geometry dimensional measurements using computed tomography at the mm and sub-mm scales

    DEFF Research Database (Denmark)

    Jiménez, Roberto; Torralba, Marta; Yagüe-Fabra, José A.

    2017-01-01

    The dimensional verification of miniaturized components with 3D complex geometries is particularly challenging. Computed Tomography (CT) can represent a suitable alternative solution to micro metrology tools based on optical and tactile techniques. However, the establishment of CT systems......’ traceability when measuring 3D complex geometries is still an open issue. In this work, an alternative method for the measurement uncertainty assessment of 3D complex geometries by using CT is presented. The method is based on the micro-CT system Maximum Permissible Error (MPE) estimation, determined...... experimentally by using several calibrated reference artefacts. The main advantage of the presented method is that a previous calibration of the component by a more accurate Coordinate Measuring System (CMS) is not needed. In fact, such CMS would still hold all the typical limitations of optical and tactile...

  13. Chinese handwriting recognition an algorithmic perspective

    CERN Document Server

    Su, Tonghua

    2013-01-01

    This book provides an algorithmic perspective on the recent development of Chinese handwriting recognition. Two technically sound strategies, the segmentation-free and integrated segmentation-recognition strategy, are investigated and algorithms that have worked well in practice are primarily focused on. Baseline systems are initially presented for these strategies and are subsequently expanded on and incrementally improved. The sophisticated algorithms covered include: 1) string sample expansion algorithms which synthesize string samples from isolated characters or distort realistic string samples; 2) enhanced feature representation algorithms, e.g. enhanced four-plane features and Delta features; 3) novel learning algorithms, such as Perceptron learning with dynamic margin, MPE training and distributed training; and lastly 4) ensemble algorithms, that is, combining the two strategies using both parallel structure and serial structure. All the while, the book moves from basic to advanced algorithms, helping ...

  14. A Hierarchical Approach Using Machine Learning Methods in Solar Photovoltaic Energy Production Forecasting

    Directory of Open Access Journals (Sweden)

    Zhaoxuan Li

    2016-01-01

    Full Text Available We evaluate and compare two common methods, artificial neural networks (ANN and support vector regression (SVR, for predicting energy productions from a solar photovoltaic (PV system in Florida 15 min, 1 h and 24 h ahead of time. A hierarchical approach is proposed based on the machine learning algorithms tested. The production data used in this work corresponds to 15 min averaged power measurements collected from 2014. The accuracy of the model is determined using computing error statistics such as mean bias error (MBE, mean absolute error (MAE, root mean square error (RMSE, relative MBE (rMBE, mean percentage error (MPE and relative RMSE (rRMSE. This work provides findings on how forecasts from individual inverters will improve the total solar power generation forecast of the PV system.

  15. Intranasal Pharmacokinetic Data for Triptans Such as Sumatriptan and Zolmitriptan Can Render Area Under the Curve (AUC) Predictions for the Oral Route: Strategy Development and Application

    DEFF Research Database (Denmark)

    Srinivas, Nuggehally R.; Syed, Muzeeb

    2016-01-01

    Limited pharmacokinetic sampling strategy may be useful for predicting the area under the curve (AUC) for triptans and may have clinical utility as a prospective tool for prediction. Using appropriate intranasal pharmacokinetic data, a Cmax vs. AUC relationship was established by linear regression...... models for sumatriptan and zolmitriptan. The predictions of the AUC values were performed using published mean/median Cmax data and appropriate regression lines. The quotient of observed and predicted values rendered fold-difference calculation. The mean absolute error (MAE), mean positive error (MPE......), mean negative error (MNE), root mean square error (RMSE), correlation coefficient (r), and the goodness of the AUC fold prediction were used to evaluate the two triptans. Also, data from the mean concentration profiles at time points of 1 hour (sumatriptan) and 3 hours (zolmitriptan) were used...

  16. Avaliação de Micro e Pequenas Empresas Utilizando a Metodologia Multicritério e o Método do Fluxo de Caixa Descontado

    Directory of Open Access Journals (Sweden)

    Marcus Vinicius Andrade de Lima

    2010-01-01

    Full Text Available Neste artigo é apresentada uma contribuição ao método do fluxo de caixa descontado utilizando a metodologia multicritério de apoio à decisão. Essa metodologia incorpora variáveis de natureza qualitativa e subjetiva ao método tradicional do fluxo de caixa descontado utilizado na avaliação de empresas. Para ilustrar o método proposto foi realizado um estudo descritivo de natureza exploratória aplicado a um multicaso. A intervenção foi em Micro e Pequenas Empresas (MPE do ramo químico, farmacêutico e de turismo. Como resultado, o avaliador ajustou o preço do negócio levando em conta a resultante da mixagem entre as duas metodologias.

  17. Artificial neural network and response surface methodology modeling in mass transfer parameters predictions during osmotic dehydration of Carica papaya L.

    Directory of Open Access Journals (Sweden)

    J. Prakash Maran

    2013-09-01

    Full Text Available In this study, a comparative approach was made between artificial neural network (ANN and response surface methodology (RSM to predict the mass transfer parameters of osmotic dehydration of papaya. The effects of process variables such as temperature, osmotic solution concentration and agitation speed on water loss, weight reduction, and solid gain during osmotic dehydration were investigated using a three-level three-factor Box-Behnken experimental design. Same design was utilized to train a feed-forward multilayered perceptron (MLP ANN with back-propagation algorithm. The predictive capabilities of the two methodologies were compared in terms of root mean square error (RMSE, mean absolute error (MAE, standard error of prediction (SEP, model predictive error (MPE, chi square statistic (χ2, and coefficient of determination (R2 based on the validation data set. The results showed that properly trained ANN model is found to be more accurate in prediction as compared to RSM model.

  18. CHIS – Letter from French health insurance authorities "Assurance Maladie" and “frontalier” status

    CERN Multimedia

    2014-01-01

    Certain members of the personnel residing in France have recently received a letter, addressed to themselves and/or their spouse, from the French health insurance authorities (Assurance Maladie) on the subject of changes in the health insurance coverage of “frontalier” workers.   It should be recalled that employed members of personnel (MPE) are not affected by the changes made by the French authorities to frontalier  workers' "right to choose" (droit d'option) in matters of health insurance (see the CHIS website for more details), which took effect as of 1 June 2014, as they are not considered to be frontalier workers. Associated members of the personnel (MPA) are not affected either, unless they live in France and are employed by a Swiss institute. For the small number of MPAs in the latter category who might be affected, as well as for family members who do have frontalier status, CERN is still in discussion with the authorities o...

  19. Diagnosis and treatment of trigeminal schwannomas extending into both the middle and posterior cranial fossa

    Institute of Scientific and Technical Information of China (English)

    徐启武; 车晓明; 胡杰; 杨伯捷

    2004-01-01

    @@ Trigeminal schwannomas (TSs) account for 0.1%-0.4% of all intracranial tumors and 1%-8% of intracranial schwannomas.1,2 Yoshida and Kawase3 classified TSs into 6 types according to their locations: M (TS involving the middle cranial fossa), P (TS involving the posterior cranial fossa), E (TS located at extracranial space), MP (TS involving both the middle and the posterior cranial fossa), ME (TS involving the middle cranial fossa and the extracranial space), and MPE (TS involving the the middle and the posterior cranial fossa and the extracranial space). Of these types, MP is the commonest, but is difficult to be totally removed. Between January 1984 and June 2003, we surgically treated 28 patients with TSs of type MP and obtained satisfactory results. To make a correct diagnosis of TS, to select appropriate surgical approach, and to improve surgical outcome of TS of type MP, we analysed the related clinical data and experiences.

  20. Diagnostic value of soluble B7-H4 and carcinoembryonic antigen in distinguishing malignant from benign pleural effusion.

    Science.gov (United States)

    Jing, Xiaogang; Wei, Fei; Li, Jing; Dai, Lingling; Wang, Xi; Jia, Liuqun; Wang, Huan; An, Lin; Yang, Yuanjian; Zhang, Guojun; Cheng, Zhe

    2018-03-01

    To explore the diagnostic value of joint detection of soluble B7-H4 (sB7-H4) and carcinoembryonic antigen (CEA) in identifying malignant pleural effusion (MPE) from benign pleural effusion (BPE). A total of 97 patients with pleural effusion specimens were enrolled from The First Affiliated Hospital of Zhengzhou University between June 2014 and December 2015. All cases were categorized into malignant pleural effusion group (n = 55) and benign pleural effusion group (n = 42) according to etiologies. Enzyme-linked immunosorbent assay was applied to examine the levels of sB7-H4 in pleural effusion and meanwhile CEA concentrations were detected by electro-chemiluminescence immunoassays. Receiver operating characteristic (ROC) curve was established to assess the diagnostic value of sB7-H4 and CEA in pleural effusion. The correlation between sB7-H4 and CEA levels was analyzed by Pearson's product-moment. The concentrations of sB7-H4 and CEA in MPE exhibited obviously higher than those of BPE ([60.08 ± 35.04] vs. [27.26 ± 9.55] ng/ml, P = .000; [41.49 ± 37.16] vs. [2.41 ± 0.94] ng/ml, P = .000). The AUC area under ROC curve of sB7-H4 and CEA was 0.884 and 0.954, respectively. Two cutoff values by ROC curve analysis of sB7-H4 36.5 ng/ml and CEA 4.18 ng/ml were obtained, with a corresponding sensitivity (81.82%, 87.28%), specificity (90.48%, 95.24%), accuracy (85.57%, 90.72%), positive predictive value (PPV) (91.84%, 96.0%), negative predictive value (NPV) (79.17%, 85.11%), positive likelihood ratio (PLR) (8.614, 18.327), and negative likelihood ratio (NLR) (0.201, 0.134). When sB7-H4 and CEA were combined to detect pleural effusion, it obtained a higher sensitivity 90.91% and specificity 97.62%. Furthermore, correlation analysis result showed that the level of sB7-H4 was correlated with CEA level (r = .770, P = .000). sB7-H4 was a potentially valuable tumor marker in the differentiation between BPE and MPE. The combined detection of sB7-H4 and

  1. An evaluation of chemical photoreactivity and the relationship to phototoxicity.

    Science.gov (United States)

    Kleinman, Mark H; Smith, Mark D; Kurali, Edit; Kleinpeter, Sarah; Jiang, Kaina; Zhang, Yongxia; Kennedy-Gabb, Sonya A; Lynch, Anthony M; Geddes, Chris D

    2010-11-01

    The existing regulatory guidance for photosafety testing of new drug products states that studies are warranted for those chemicals that both absorb light in the range of 290-700 nm, and that are either applied locally/topically, or "reach" (EMEA)/"significantly partition" (FDA) to the skin or eyes. The initial in vitro study recommended for the assessment of phototoxic potential is the 3T3 Neutral Red Uptake (NRU) Assay. The current study was undertaken to establish superior triggers for the initiation of biological photosafety testing. In this study, photophysical and photochemical parameters for 40 drug or drug-like molecules were studied. Principal Component Analysis (PCA), Partial Least Squares-Discriminant Analysis (PLS-DA), and a fivefold cross-validation PLS algorithm were used to evaluate the relationship between subsets of photophysical and photochemical parameters with the 3T3 NRU PIF/MPE (Photo Irritation Factor/Mean Photo Effect) results. The parameters most indicative of a 3T3 NRU positive PIF or MPE score were the extent of degradation in solution, the quantum yield of formation of singlet oxygen and the relative formation of superoxide anion. The results demonstrate that while absorption of light is critical to the induction of a light-induced process, it is the resultant events that may be used to predict the 3T3 NRU assay result. It is therefore proposed that the trigger for photosafety testing be revised to include a molecular basis for photoreactivity. From this limited investigation, estimated thresholds leading to 3T3 NRU positive results due to photodegradation, formation of singlet oxygen quantum yield or a relative superoxide anion formation value are proposed. Copyright © 2010 Elsevier Inc. All rights reserved.

  2. Identification of tertiary butyl alcohol (TBA)-utilizing organisms in BioGAC reactors using 13C-DNA stable isotope probing.

    Science.gov (United States)

    Aslett, Denise; Haas, Joseph; Hyman, Michael

    2011-09-01

    Biodegradation of the gasoline oxygenates methyl tertiary-butyl ether (MTBE) and ethyl tertiary-butyl ether (ETBE) can cause tertiary butyl alcohol (TBA) to accumulate in gasoline-impacted environments. One remediation option for TBA-contaminated groundwater involves oxygenated granulated activated carbon (GAC) reactors that have been self-inoculated by indigenous TBA-degrading microorganisms in ground water extracted from contaminated aquifers. Identification of these organisms is important for understanding the range of TBA-metabolizing organisms in nature and for determining whether self-inoculation of similar reactors is likely to occur at other sites. In this study (13)C-DNA-stable isotope probing (SIP) was used to identify TBA-utilizing organisms in samples of self-inoculated BioGAC reactors operated at sites in New York and California. Based on 16S rRNA nucleotide sequences, all TBA-utilizing organisms identified were members of the Burkholderiales order of the β-proteobacteria. Organisms similar to Cupriavidus and Methylibium were observed in both reactor samples while organisms similar to Polaromonas and Rhodoferax were unique to the reactor sample from New York. Organisms similar to Hydrogenophaga and Paucibacter strains were only detected in the reactor sample from California. We also analyzed our samples for the presence of several genes previously implicated in TBA oxidation by pure cultures of bacteria. Genes Mpe_B0532, B0541, B0555, and B0561 were all detected in (13)C-metagenomic DNA from both reactors and deduced amino acid sequences suggested these genes all encode highly conserved enzymes. One gene (Mpe_B0555) encodes a putative phthalate dioxygenase-like enzyme that may be particularly appropriate for determining the potential for TBA oxidation in contaminated environmental samples.

  3. Development and blood compatibility assessment of electrospun polyvinyl alcohol blended with metallocene polyethylene and plectranthus amboinicus (PVA/mPE/PA) for bone tissue engineering.

    Science.gov (United States)

    Qi, Jie; Zhang, Huang; Wang, Yingzhou; Mani, Mohan Prasath; Jaganathan, Saravana Kumar

    2018-01-01

    Currently, the design of extracellular matrix (ECM) with nanoscale properties in bone tissue engineering is challenging. For bone tissue engineering, the ECM must have certain properties such as being nontoxic, highly porous, and should not cause foreign body reactions. In this study, the hybrid scaffold based on polyvinyl alcohol (PVA) blended with metallocene polyethylene (mPE) and plectranthus amboinicus (PA) was fabricated for bone tissue engineering via electrospinning. The fabricated hybrid nanocomposites were characterized by scanning electron microscopy (SEM), Fourier transform and infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), contact angle measurement, and atomic force microscopy (AFM). Furthermore, activated partial thromboplastin time (APTT), prothrombin time (PT), and hemolytic assays were used to investigate the blood compatibility of the prepared hybrid nanocomposites. The prepared hybrid nanocomposites showed reduced fiber diameter (238±45 nm) and also increased porosity (87%) with decreased pore diameter (340±86 nm) compared with pure PVA. The interactions between PVA, mPE, and PA were identified by the formation of the additional peaks as revealed in FTIR. Furthermore, the prepared hybrid nanocomposites showed a decreased contact angle of 51°±1.32° indicating a hydrophilic nature and exhibited lower thermal stability compared to pristine PVA. Moreover, the mechanical results revealed that the electrospun scaffold showed an improved tensile strength of 3.55±0.29 MPa compared with the pristine PVA (1.8±0.52 MPa). The prepared hybrid nanocomposites showed delayed blood clotting as noted in APTT and PT assays indicating better blood compatibility. Moreover, the hemolysis assay revealed that the hybrid nanocomposites exhibited a low hemolytic index of 0.6% compared with pure PVA, which was 1.6% suggesting the safety of the developed nanocomposite to red blood cells (RBCs). The prepared nanocomposites exhibited better physico

  4. Action spectrum for photochemical retinal pigment epithelium (RPE) disruption in an in vivo monkey model

    Science.gov (United States)

    Zhang, Jie; Sabarinathan, Ranjani; Bubel, Tracy; Williams, David R.; Hunter, Jennifer J.

    2016-03-01

    Observations of RPE disruption and autofluorescence (AF) photobleaching at light levels below the ANSI photochemical maximum permissible exposure (MPE) (Morgan et al., 2008) indicates a demand to modify future light safety standards to protect the retina from harm. To establish safe light exposures, we measured the visible light action spectrum for RPE disruption in an in vivo monkey model with fluorescence adaptive optics retinal imaging. Using this high resolution imaging modality can provide insight into the consequences of light on a cellular level and allow for longitudinal monitoring of retinal changes. The threshold retinal radiant exposures (RRE) for RPE disruption were determined for 4 wavelengths (460, 488, 544, and 594 nm). The anaesthetized macaque retina was exposed to a uniform 0.5° × 0.5° field of view (FOV). Imaging within a 2° × 2° FOV was performed before, immediately after and at 2 week intervals for 10 weeks. At each wavelength, multiple RREs were tested with 4 repetitions each to determine the threshold for RPE disruption. For qualitative analysis, RPE disruption is defined as any detectable change from the pre exposure condition in the cell mosaic in the exposed region relative to the corresponding mosaic in the immediately surrounding area. We have tested several metrics to evaluate the RPE images obtained before and after exposure. The measured action spectrum for photochemical RPE disruption has a shallower slope than the current ANSI photochemical MPE for the same conditions and suggests that longer wavelength light is more hazardous than other measurements would suggest.

  5. [Occupational exposure of welders to ultraviolet and "blue light" radiation emitted during TIG and MMA welding based on field measurements].

    Science.gov (United States)

    Wolska, Agnieszka

    2013-01-01

    The aim of the study was to present the results of welders' occupational exposure to "blue light" and UV radiation carried out at industrial workstations during TIG and MMA welding. Measurements were performed at 13 workstations (TIG welding: 6; MMA welding: 7), at which different welding parameters and materials were used. The radiation level was measured using a wide-range radiometer and a set of detectors, whose spectral responses were adequately fit to particular hazard under study. The measurement points corresponded with the location of eye and hand. The highest values of eye irradiance were found for aluminum TIG welding. Effective irradiance of actinic UV was within the range E(s) = 7.79-37.6 W/m2; UVA total irradiance, E(UVA) = 18-53.1 W/m2 and effective blue-light irradiance E(B) = 35-67 W/m2. The maximum allowance time ranged from 1.7 to 75 s, which means that in some cases even unintentional very short eye exposure can exceed MPE. The influence of welded material and the type of electrode coating on the measured radiation level were evidenced. The exceeded value of MPE for photochemical hazard arising for the eyes and skin was found at all measured workstations. Welders should use appropriately the eye and face protective equipment and avoid direct staring at welding arc when starting an arc-welding operation. Besides, the lack of head and neck skin protection can induce acute and chronic harmful health effects. Therefore, an appropriate wear of personal protective equipment is essential for welders' health.

  6. Carbohydrate co-ingestion with protein does not further augment post-prandial muscle protein accretion in older men

    Directory of Open Access Journals (Sweden)

    Hamer Henrike M

    2013-01-01

    Full Text Available Abstract Background A blunted muscle protein synthetic response to protein ingestion may contribute to the age related loss of muscle tissue. We hypothesized that the greater endogenous insulin release following co-ingestion of carbohydrate facilitates post-prandial muscle protein accretion after ingesting a meal-like bolus of protein in older males. Methods Twenty-four healthy older men (75±1 y were randomly assigned to ingest 20 g intrinsically L-[1-13C] phenylalanine-labeled casein protein with (PRO-CHO or without (PRO 40 g carbohydrate. Ingestion of specifically produced intrinsically L-[1-13C] phenylalanine labeled protein allowed us to assess post-prandial incorporation of dietary protein derived amino acids into muscle protein. Blood samples were collected at regular intervals, with muscle biopsies being obtained prior to and 2 and 6 h after protein ingestion. Results Plasma glucose and insulin concentrations showed a greater increase in PRO-CHO compared with PRO (P13C] phenylalanine enrichments tended to increase to a greater extent in PRO-CHO compared with PRO during the first 2 h after protein ingestion (0.0072±0.0013 vs 0.0046±0.010 MPE, respectively; P=0.13. However, 6 h after protein ingestion, differences in muscle protein-bound L-[1-13C] phenylalanine enrichments were no longer observed between experiments (0.0213±0.0024 vs 0.0185±0.0010 MPE, respectively; P=0.30. Conclusions This study shows that carbohydrate ingestion may accelerate, but does not further augment post-prandial incorporation of dietary protein derived amino acids into muscle protein in healthy elderly men.

  7. An effective placental cotyledons proteins extraction method for 2D gel electrophoresis.

    Science.gov (United States)

    Tan, Niu J; Daim, Leona D J; Jamil, Amilia A M; Mohtarrudin, Norhafizah; Thilakavathy, Karuppiah

    2017-03-01

    Effective protein extraction is essential especially in producing a well-resolved proteome on 2D gels. A well-resolved placental cotyledon proteome, with good reproducibility, have allowed researchers to study the proteins underlying the physiology and pathophysiology of pregnancy. The aim of this study is to determine the best protein extraction protocol for the extraction of protein from placental cotyledons tissues for a two-dimensional gel electrophoresis (2D-GE). Based on widely used protein extraction strategies, 12 different extraction methodologies were carefully selected, which included one chemical extraction, two mechanical extraction coupled protein precipitations, and nine chemical extraction coupled protein precipitations. Extracted proteins were resolved in a one-dimensional gel electrophoresis and 2D-GE; then, it was compared with set criteria: extraction efficacy, protein resolution, reproducibility, and recovery efficiency. Our results revealed that a better profile was obtained by chemical extraction in comparison to mechanical extraction. We further compared chemical extraction coupled protein precipitation methodologies, where the DNase/lithium chloride-dense sucrose homogenization coupled dichloromethane-methanol precipitation (DNase/LiCl-DSH-D/MPE) method showed good protein extraction efficiency. This, however, was carried out with the best protein resolution and proteome reproducibility on 2D-gels. DNase/LiCl-DSH-D/MPE was efficient in the extraction of proteins from placental cotyledons tissues. In addition, this methodology could hypothetically allow the protein extraction of any tissue that contains highly abundant lipid and glycogen. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. [Study on the pathogens correlated to sexually transmitted diseases in 285 pre-pubertal girls with vulvovaginitis in Beijing].

    Science.gov (United States)

    Liu, Xiao-Yan; Sun, Hong-Mei; Feng, Yan-Ling; Hu, Jin; Zhao, Han-Qing; Zhang, Li-Ya

    2007-08-01

    To study the relationship between vulvovaginitis in pre-pubertal girls and pathogens as Chlamydia trachomatis (Ct), N. gonorrhoeae (Ng), Mycoplasma, Ureaplasma urealyticum (Uu), Mycoplasma hominis (Mh), M. genitalium (Mg), M. fermentans (Mf) and M. penetrans (Mpe), as well as to find out the proportion of mycoplasma which is correlated to sexually transmitted diseases (STD) and AIDS. METHODS Vulvae swab specimens from 285 pre-pubertal girls with vulvovaginitis (case group) and 128 healthy girls (control group) were collected and detected by nested polymerase chain reaction (nPCR) to identify the existence of pathogens as Ct, Ng, Uu, Mh, Mg, Mf and Mpe. nPCR with both high specificity and sensitivity, would not be influenced by the amount of pathogens in specimens or inactivated during the process of storage or transportation. The rate of detection on pathogens was 59.65% in the 285 specimens from case group including 'one kind of pathogen in one specimen' as 37.54% and 'two kinds' as 16.84% and 'three kinds' as 5.26%. However, in the 128 specimens from control group, the detectable rate of pathogen was 6.25%. Relationships were found between Ng (P vulvovaginitis in pre-pubertal girls. In control group the pathogens were detected from 7 specimens including 5 Uu and 2 Mh. Some of the pathogens were correlated to STD and were important in causing vulvovaginitis in pre-pubertal girls. Vulvovaginitis might have been caused by more than one kind of pathogen in pre-pubertal girls. The locations of Mg, Mf and Ng in outer genital tracts were correlated to seasonal change. Macrolide seemed to be quite effective clinically in treating urogenital tract infection caused by mycoplasma and Ct.

  9. Home composting as an alternative treatment option for organic household waste in Denmark: An environmental assessment using life cycle assessment-modelling

    International Nuclear Information System (INIS)

    Andersen, J.K.; Boldrin, A.; Christensen, T.H.; Scheutz, C.

    2012-01-01

    An environmental assessment of the management of organic household waste (OHW) was performed from a life cycle perspective by means of the waste-life cycle assessment (LCA) model EASEWASTE. The focus was on home composting of OHW in Denmark and six different home composting units (with different input and different mixing frequencies) were modelled. In addition, incineration and landfilling was modelled as alternatives to home composting. The most important processes contributing to the environmental impact of home composting were identified as greenhouse gas (GHG) emissions (load) and the avoided emissions in relation to the substitution of fertiliser and peat when compost was used in hobby gardening (saving). The replacement of fertiliser and peat was also identified as one of the most sensible parameters, which could potentially have a significant environmental benefit. Many of the impact categories (especially human toxicity via water (HTw) and soil (HTs)) were affected by the heavy metal contents of the incoming OHW. The concentrations of heavy metals in the compost were below the threshold values for compost used on land and were thus not considered to constitute a problem. The GHG emissions were, on the other hand, dependent on the management of the composting units. The frequently mixed composting units had the highest GHG emissions. The environmental profiles of the home composting scenarios were in the order of −2 to 16 milli person equivalents (mPE) Mg −1 wet waste (ww) for the non-toxic categories and −0.9 to 28 mPE Mg −1 ww for the toxic categories. Home composting performed better than or as good as incineration and landfilling in several of the potential impact categories. One exception was the global warming (GW) category, in which incineration performed better due to the substitution of heat and electricity based on fossil fuels.

  10. Occupational exposure of welders to ultraviolet and "blue light" radiation emitted during TIG and MMA welding based on field measuremants

    Directory of Open Access Journals (Sweden)

    Agnieszka Wolska

    2013-02-01

    Full Text Available Background: The aim of the study was to present the results of welders' occupational exposure to "blue light" and UV radiation carried out at industrial workstations during TIG and MMA welding. Materials and methods: Measurements were performed at 13 workstations (TIG welding: 6; MMA welding: 7, at which different welding parameters and materials were used. The radiation level was measured using a wide-range radiometer and a set of detectors, whose spectral responses were adequately fit to particular hazard under study. The measurement points corresponded with the location of eye and hand. Results: The highest values of eye irradiance were found for aluminum TIG welding. Effective irradiance of actinic UV was within the range Es = 7.79-37.6 W/m2; UVA total irradiance, EUVA = 18-53.1 W/m2 and effective blue-light irradiance EB = 35-67 W/m2. The maximum allowance time ranged from 1.7 to 75 s, which means that in some cases even unintentional very short eye exposure can exceed MPE. Conclusions: The influence of welded material and the type of electrode coating on the measured radiation level were evidenced. The exceeded value of MPE for photochemical hazard arising for the eyes and skin was found at all measured workstations. Welders should use appropriately the eye and face protective equipment and avoid direct staring at welding arc when starting an arcwelding operation. Besides, the lack of head and neck skin protection can induce acute and chronic harmful health effects. Therefore, an appropriate wear of personal protective equipment is essential for welders' health. Med Pr 2013;64(1:69–82

  11. Analgesic effect of the aqueous and ethanolic extracts of clove

    Directory of Open Access Journals (Sweden)

    Mina Kamkar Asl

    2013-04-01

    Full Text Available Objective: The beneficial effects of clove on toothache have been well documented. We have also previously shown the analgesic effects of clove essential oil. The present work was done to investigate the analgesic effects of the aqueous extract of clove using hot plate test. The possible role of opioid receptors in the analgesic effects of clove was also investigated using naloxone. Materials and Methods: Ninety male mice were divided into nine groups: (1 Saline, (2-4 Aaqueous (Aq 50, Aq 100, and Aq 200 groups which were treated with 50, 100, and 200 mg/kg of aqueous extract of clove, respectively, (5-7 Ethanolic (Eth 50, Eth 100, and Eth 200 groups which were treated with 50, 100, and 200 mg/kg of ethanolic extract of clove, respectively, and (8-9 Aq 100- Naloxone and Aq 200- Naloxone which were pretreated with 4 mg/kg of naloxone before injection of 100 or 200 mg/kg of the aqueous extract. The hot plate test was performed as a base record 10 min before injection of drugs and consequently repeated every 10 minutes after the injection. Results: The maximal percent effect (MPE in the animal groups treated with 50, 100, and 200 mg/kg of aqueous extract was significantly higher than the control group. Pretreatment with naloxone reduced the analgesic effects of both 100 and 200 mg/kg of the aqueous extract. Administration of all three doses of the ethanloic extract also non-significantly increased the MPE. Conclusion: The results of the present study showed that aqueous extract of clove has analgesic effect in mice demonstrated by hot plate test which is reversible by naloxone. The role of opioid system in the analgesic effect of clove might be suggested. However, more investigations are needed to elucidate the exact mechanism(s.

  12. Incorporating Satellite Precipitation Estimates into a Radar-Gauge Multi-Sensor Precipitation Estimation Algorithm

    Directory of Open Access Journals (Sweden)

    Yuxiang He

    2018-01-01

    Full Text Available This paper presents a new and enhanced fusion module for the Multi-Sensor Precipitation Estimator (MPE that would objectively blend real-time satellite quantitative precipitation estimates (SQPE with radar and gauge estimates. This module consists of a preprocessor that mitigates systematic bias in SQPE, and a two-way blending routine that statistically fuses adjusted SQPE with radar estimates. The preprocessor not only corrects systematic bias in SQPE, but also improves the spatial distribution of precipitation based on SQPE and makes it closely resemble that of radar-based observations. It uses a more sophisticated radar-satellite merging technique to blend preprocessed datasets, and provides a better overall QPE product. The performance of the new satellite-radar-gauge blending module is assessed using independent rain gauge data over a five-year period between 2003–2007, and the assessment evaluates the accuracy of newly developed satellite-radar-gauge (SRG blended products versus that of radar-gauge products (which represents MPE algorithm currently used in the NWS (National Weather Service operations over two regions: (I Inside radar effective coverage and (II immediately outside radar coverage. The outcomes of the evaluation indicate (a ingest of SQPE over areas within effective radar coverage improve the quality of QPE by mitigating the errors in radar estimates in region I; and (b blending of radar, gauge, and satellite estimates over region II leads to reduction of errors relative to bias-corrected SQPE. In addition, the new module alleviates the discontinuities along the boundaries of radar effective coverage otherwise seen when SQPE is used directly to fill the areas outside of effective radar coverage.

  13. The CD44(high tumorigenic subsets in lung cancer biospecimens are enriched for low miR-34a expression.

    Directory of Open Access Journals (Sweden)

    Saroj K Basak

    Full Text Available Cellular heterogeneity is an integral part of cancer development and progression. Progression can be associated with emergence of cells that exhibit high phenotypic plasticity (including "de-differentiation" to primitive developmental states, and aggressive behavioral properties (including high tumorigenic potentials. We observed that many biomarkers that are used to identify Cancer Stem Cells (CSC can label cell subsets in an advanced clinical stage of lung cancer (malignant pleural effusions, or MPE. Thus, CSC-biomarkers may be useful for live sorting functionally distinct cell subsets from individual tumors, which may enable investigators to hone in on the molecular basis for functional heterogeneity. We demonstrate that the CD44(hi (CD44-high cancer cell subsets display higher clonal, colony forming potential than CD44(lo cells (n=3 and are also tumorigenic (n=2/2 when transplanted in mouse xenograft model. The CD44(hi subsets express different levels of embryonal (de-differentiation markers or chromatin regulators. In archived lung cancer tissues, ALDH markers co-localize more with CD44 in squamous cell carcinoma (n=5/7 than Adeno Carcinoma (n=1/12. MPE cancer cells and a lung cancer cell line (NCI-H-2122 exhibit chromosomal abnormalities and 1p36 deletion (n=3/3. Since miR-34a maps to the 1p36 deletion site, low miR-34a expression levels were detected in these cells. The colony forming efficiency of CD44(hi cells, characteristic property of CSC, can be inhibited by mir-34a replacement in these samples. In addition the highly tumorigenic CD44(hi cells are enriched for cells in the G2 phase of cell cycle.

  14. Gestão de capital de giro: contribuição para as micro e pequenas empresas no Brasil

    Directory of Open Access Journals (Sweden)

    Deborah Moraes Zouain

    2011-06-01

    Full Text Available Este artigo trata da importância das questões de capital de giro na gestão das micro e pequenas empresas (MPE no Brasil. Apresenta-se uma revisão dos conceitos de capital de giro e da importância das MPE no Brasil, além de uma discussão sobre a relevância de uma gestão financeira de curto prazo eficiente para o sucesso de um empreendimento de pequeno porte. Com características bem definidas, as micro e pequenas empresas são responsáveis pela geração da maior parte dos empregos formais no Brasil; apesar disso, ainda não contam com uma estrutura formal de apoio de crédito. O trabalho aponta como fator relevante para o sucesso das micro e pequenas empresas ter um bom gerenciamento do capital de giro. O mau gerenciamento desse fator contribui para o alto índice de mortalidade dessas empresas. Para que o administrador de capital de giro tenha êxito, é importante que haja um forte entrelaçamento com a administração estratégica, para uma solução definitiva do problema, isto é, que consista numa recuperação de lucratividade da empresa e as consequentes recomposições de seu fluxo de caixa, fazendo com que as micro e pequenas empresas consigam chegar à fase de maturidade.

  15. Fortune favours the bold: a higher predator reduces the impact of a native but not an invasive intermediate predator.

    Science.gov (United States)

    Barrios-O'Neill, Daniel; Dick, Jaimie T A; Emmerson, Mark C; Ricciardi, Anthony; MacIsaac, Hugh J; Alexander, Mhairi E; Bovy, Helene C

    2014-05-01

    Emergent multiple predator effects (MPEs) might radically alter predictions of predatory impact that are based solely on the impact of individuals. In the context of biological invasions, determining if and how the individual-level impacts of invasive predators relates to their impacts in multiple-individual situations will inform understanding of how such impacts might propagate through recipient communities. Here, we use functional responses (the relationship between prey consumption rate and prey density) to compare the impacts of the invasive freshwater mysid crustacean Hemimysis anomala with a native counterpart Mysis salemaai when feeding on basal cladoceran prey (i) as individuals, (ii) in conspecific groups and (iii) in conspecific groups in the presence of a higher fish predator, Gasterosteus aculeatus. In the absence of the higher predator, the invader consumed significantly more basal prey than the native, and consumption was additive for both mysid species - that is, group consumption was predictable from individual-level consumption. Invaders and natives were themselves equally susceptible to predation when feeding with the higher fish predator, but an MPE occurred only between the natives and higher predator, where consumption of basal prey was significantly reduced. In contrast, consumption by the invaders and higher predator remained additive. The presence of a higher predator serves to exacerbate the existing difference in individual-level consumption between invasive and native mysids. We attribute the mechanism responsible for the MPE associated with the native to a trait-mediated indirect interaction, and further suggest that the relative indifference to predator threat on the part of the invader contributes to its success and impacts within invaded communities. © 2013 The Authors. Journal of Animal Ecology © 2013 British Ecological Society.

  16. Pleural effusion in 11:14 translocation q1 multiple myeloma in the setting of proteasome inhibitor presents therapeutic complexity.

    Science.gov (United States)

    Ghannam, Malik; Bryan, Maria; Kuross, Erik; Berry, Brent

    2018-01-01

    Primary malignant pleural effusion has been reported in about 134 cases of multiple myeloma (MM). Associated pleural effusions in cases of MM portend a poor prognosis and identifying them is highly relevant. Reported is the case of a man diagnosed with MM who developed primary myelomatous pleural effusion in the setting of multiple relapses and subsequent mortality within 2 months of the pleural effusion diagnosis. A 61-year-old African American man was diagnosed with MM in 2011. He received induction therapy of lenalidomide and dexamethasone and an autologous stem cell transplant in 2012. Over the next 5 years, the patient went through alternating periods of remission and relapse that were treated with two rounds of thoracic spine radiation therapy and chemotherapeutic agents. In September 2017, the patient presented with worsening dyspnea and was found to have pleural effusion. Fluid analysis showed plasma cell dyscrasia. Fluid drainage was performed, then the patient was discharged after 1 week which was followed by rapid re-accumulation of fluid and rehospitalization about 10 days after discharge. The patient passed away a few weeks after the second admission. Pleural effusion carries a differential diagnosis which may include malignancy but is commonly thought to be less specific to multiple myeloma but should still remain in the differential diagnosis. To our knowledge, this is the first case of myelomatous pleural effusion (MPE) that was reported after multiple relapses of MM. MPE is a very rare complication of MM, and its presence is a strong indicator of imminent mortality and need for comfort care in case of multiple relapses. End-stage pleural effusion in MM in the setting of proteasome inhibitor adds more therapeutic and diagnostic challenges.

  17. Effect of pregnancy on potency of bupivacaine for spinal anesthesia in rats%妊娠对大鼠布比卡因脊麻效力的影响

    Institute of Scientific and Technical Information of China (English)

    崔睿; 徐世元; 雷洪伊; 蔡清香; 王冬梅

    2010-01-01

    目的 探讨妊娠对大鼠布比卡因脊麻效力的影响.方法 雌性SD大鼠,非孕鼠体重180~220 g,孕鼠(孕17 d)体重350~400 g.取鞘内置管成功的非孕鼠及孕鼠各18只,非孕鼠随机分为3组(n=6):正常对照组(C组)、2%布比卡因组(B2组)及4%布比卡因组(B4组);孕鼠随机分为3组(n=6):对照组(PC组)、2%布比卡因组(PB2组)及4%布比卡因组(PB4组).C组与PC组:鞘内注射生理盐水30μl,其余4组相应鞘内分别注入2%或4%布比卡因30μl.分别于给药前(基础状态)、给药后10 min、20 min、30 min、1h、2 h、4 h、1 d、2 d、3 d和4 d时测定甩尾反应潜伏期,计算最大镇痛效应百分比(MPE);并进行后肢运动功能(MF)评分.结果 与基础值比较,B2组于给药后10 min~2 h时MPE升高,给药后10 min~1 h时MF评分升高;B4组于给药后10 min~4 h时MPE升高,给药后10 min~1 h时MF评分升高;PB2组于给药后10 min~1 d时MPE升高,给药后10 min~2 h时MF评分升高;PB4组于给药后10 min~1 d时MPE升高,给药后10 min~4 h时MF评分升高(P<0.05).结论 妊娠可增加大鼠布比卡因脊麻的效力.%Objective To investigate the effect of pregnancy on the potency of bupivacaine for spinal anesthesia in rats. Methods Female non-pregnant SD rats weighing 180-220 g and 17 day pregnant SD rats weighing 350-400 g were used in this study. The rats ( 18 non-pregnant, 18 pregnant) in which PE-10 catheter were successfully placed without complications were selected. The 18 non-pregnant rats were randomly divided into 3 groups (n =6 each): control group (group C), 2% bupivacaine group (group B2 ) and 4% bupivacaine group (group B4). The 18 pregnant rats were also randomly divided into 3 groups (n = 6 each): control group (group PC),2% bupivacaine group (group PB2 ) and 4% bupivacaine group (group PB4 ). Group C and PC received intrathecal (IT) normal saline 30 μl, and the other 4 groups received 2% or 4% bupivacaine 30 μl intrathecally. Analgesia was

  18. Ocular ultraviolet radiation exposure of welders.

    Science.gov (United States)

    Tenkate, Thomas D

    2017-05-01

    I read with interest a recent paper in your journal by Slagor et al on the risk of cataract in relation to metal arc welding (1). The authors highlight that even though welders are exposed to substantial levels of ultraviolet radiation (UVR), "no studies have reported data on how much UVR welders' eyes are exposed to during a working day. Thus, we do not know whether welders are more or less exposed to UVR than outdoor workers" (1, p451). Undertaking accurate exposure assessment of UVR from welding arcs is difficult, however, two studies have reported ocular/facial UVR levels underneath welding helmets (2, 3). In the first paper, UVR levels were measured using polysulphone film dosimeters applied to the cheeks of a patient who suffered from severe facial dermatitis (2). UVR levels of four times the American Conference of Governmental Industrial Hygienists (ACGIH) maximum permissible exposure (MPE) (4) were measured on the workers left cheek and nine times the MPE on the right cheek. The authors concluded that the workers dermatitis was likely to have been due to the UVR exposure received during welding. In the other paper, a comprehensive exposure assessment of personal UVR exposure of workers in a welding environment was reported (3). The study was conducted at a metal fabrication workshop with participants being welders, boilermakers and non-welders (eg, supervisors, fitters, machinists). Polysulphone film dosimeters were again used to measure UVR exposure of the workers, with badges worn on the clothing of workers (in the chest area), on the exterior of welding helmets, attached to 11 locations on the inside of welding helmets, and on the bridge and side-shields of safety spectacles. Dosimeters were also attached to surfaces throughout the workshop to measure ambient UVR levels. For welding subjects, mean 8-hour UVR doses within the welding helmets ranged from around 9 mJ/cm 2 (3×MPE) on the inside of the helmets to around 15 mJ/cm 2 (5×MPE) on the headband (a

  19. Naturkraft integration at Kaarstoe. Mapping study report 6 march 2009

    Energy Technology Data Exchange (ETDEWEB)

    Odland, Oeystein; Hoeie, Hans; Aanestad, Per; Hauge, Bjoern I.; Solvang, Svein; Boee, Stein Espen; Lervik, Steinar; Kristiansen, Arild

    2007-07-01

    Gassco is engaged in three different studies and projects related to reduce CO{sub 2} emissions at Kaarstoe; 1. Gassnova's CO{sub 2} capture, transport and storage projects at Kaarstoe and Mongstad (the CO{sub 2} Transportation Network), where Gassco role is to mature the transportation facilities of the project. An investment decision is planned for second half of 2009. 2. The Kaarstoe Flue Gas Capture pre-feasibility study initiated by the MPE to Gassco as operator of Gassled in connection with approval of the Kaarstoe Expansion Project 2010, to evaluate the potential of capturing the CO{sub 2} emissions at the Kaarstoe gas processing plant, and reported to the MPE 3 March 2009, and 3. This Naturkraft Integration Mapping Study initiated by MPE to meet the requirements set out by the letter to Gassco dated 3 December 2008 to evaluate possibilities to integrate existing Naturkraft's power plant with the Kaarstoe gas processing plant. In this Naturkraft Integration Study report Gassco has identified potential degrees of integration and resulting impact with respect to performance of both the Naturkraft power plant and the Kaarstoe gas processing plant. A major concern related to operations of the Kaarstoe gas processing plant is the regularity and availability issues related to natural gas and NGL export. The value of the petroleum transported over Kaarstoe on any day exceeds 200 million NOK. In addition also significant oil production will be shut down if the Kaarstoe gas processing plant is not operating. Hence the regularity of energy supply including steam is of utmost importance. The integration between Naturkraft and the gas processing plant is based on supplying energy (i.e. fuel gas, steam, heat and electricity) from Naturkraft's existing power plant, and therefore must be based on predictable and steady operations of the Naturkraft power plant. Naturkraft has only been in operation for a few weeks from the start-up of the power plant 1

  20. A NASA Strategy for Leveraging Emerging Launch Vehicles for Routine, Small Payload Missions

    Science.gov (United States)

    Underwood, Bruce E.

    2005-01-01

    Orbital flight opportunities for small payloads have always been few and far between, and then on February 1, 2002, the situation got worse. In the wake of the loss of the Columbia during STS- 107, changing NASA missions and priorities led to the termination of the Shuttle Small Payloads Projects, including Get-Away Special, Hitcbker, and Space Experiment Module. In spite of the limited opportunities, long queue, and restrictions associated with flying experiments on a man-rated transportation system; the carriers provided a sustained, high quality experiment services for education, science, and technology payloads, and was one of the few games in town. Attempts to establish routine opportunities aboard existing ELVs have been unsuccessful, as the cost-per-pound on small ELVs and conflicts with primary spacecraft on larger vehicles have proven prohibitive. Ths has led to a backlog of existing NASA-sponsored payloads and no prospects or plans for fbture opportunities within the NASA community. The prospects for breaking out of this paradigm appear promising as a result of NASA s partnership with DARPA in pursuit of low-cost, responsive small ELVs under the Falcon Program. Through this partnership several new small ELVs, providing 1000 lbs. to LEO will be demonstrated in less than two years that promise costs that are reasonable enough that NASA, DoD, and other sponsors can once again invest in small payload opportunities. Within NASA, planning has already begun. NASA will be populating one or more of the Falcon demonstration flights with small payloads that are already under development. To accommodate these experiments, Goddard s Wallops Flight Facility has been tasked to develop a multi-payload ejector (MPE) to accommodate the needs of these payloads. The MPE capabilities and design is described in detail in a separately submitted abstract. Beyond use of the demonstration flights however, Goddard has already begun developing strategies to leverage these new ELVs

  1. Establishment of A Malignant Pleural Effusion Mouse Model with Lewis Lung 
Carcinoma Cell Lines Expressing Enhanced Green Fluorescent Protein

    Directory of Open Access Journals (Sweden)

    Xingqun MA

    2012-06-01

    Full Text Available Background and objective Malignant pleural effusion (MPE is a poor prognosis factor in patients with advanced lung cancer. The aim of this study is to establish a mouse model of MPE using Lewis lung carcinoma (LLC cell lines expressing enhanced green fluorescent protein (EGFP. Methods The mouse model was created by injecting LLC-EGFP cells directly into the pleural cavity of mice that were sacrificed periodically. The dynamic growth and metastasis of tumor cells were screened using in vivo fluorescence imaging. The remaining mice were subjected to transverse computed tomography (CT imaging periodically to analyze the formation rate of pleural effusion. The survival rate and tumor metastasis were also observed. Pleural fluid was gently aspirated using a 1 mL syringe and its volume was measured. When two or more mice bore pleural effusion at the same time, we calculated the average volume. The correlation of pleural effusion with the integrated optical density (IOD were analyzed. Results Four days after the inoculation of LLC-EGFP cells, green fluorescence was observed by opening the chest wall. The tumor formation rate was 100%, and the IOD gradually increased after inoculation. The metastasis sites were mediastinal, and the hilar lymph nodes were contralateral pleural as well as pericardial. The metastasis rates were 87%, 73% and 20%, respectively. The CT scan revealed that the formation rates of pleural effusion on days 7, 14 and 21 were 13%, 46% and 53%, respectively. The average volume of pleural effusion increased obviously on day 10 and peaked on day 16 with a value of 0.5 mL. The mean survival time of nude mice was 28.8 days. The volume of pleural effusion and IOD were significantly correlated (r=0.91, P<0.000,1. Conclusion A mouse model of lung cancer malignant pleural effusion was successfully established by injecting LLC lines expressing EGFP into the pleural cavity under a microscope. The model can enable dynamic observations of the

  2. Neuromuscular electrical stimulation prior to presleep protein feeding stimulates the use of protein-derived amino acids for overnight muscle protein synthesis.

    Science.gov (United States)

    Dirks, Marlou L; Groen, Bart B L; Franssen, Rinske; van Kranenburg, Janneau; van Loon, Luc J C

    2017-01-01

    Short periods of muscle disuse result in substantial skeletal muscle atrophy. Recently, we showed that both neuromuscular electrical stimulation (NMES) as well as presleep dietary protein ingestion represent effective strategies to stimulate muscle protein synthesis rates. In this study, we test our hypothesis that NMES can augment the use of presleep protein-derived amino acids for overnight muscle protein synthesis in older men. Twenty healthy, older [69 ± 1 (SE) yr] men were subjected to 24 h of bed rest, starting at 8:00 AM. In the evening, volunteers were subjected to 70-min 1-legged NMES, while the other leg served as nonstimulated control (CON). Immediately following NMES, 40 g of intrinsically l-[1- 13 C]-phenylalanine labeled protein was ingested prior to sleep. Blood samples were taken throughout the night, and muscle biopsies were obtained from both legs in the evening and the following morning (8 h after protein ingestion) to assess dietary protein-derived l-[1- 13 C]-phenylalanine enrichments in myofibrillar protein. Plasma phenylalanine concentrations and plasma l-[1- 13 C]-phenylalanine enrichments increased significantly following protein ingestion and remained elevated for up to 6 h after protein ingestion (P protein-bound l-[1- 13 C]-phenylalanine enrichments (MPE) increased to a greater extent in the stimulated compared with the control leg (0.0344 ± 0.0019 vs. 0.0297 ± 0.0016 MPE, respectively; P protein-derived amino acids in the NMES compared with CON leg. In conclusion, application of NMES prior to presleep protein feeding stimulates the use of dietary protein-derived amino acids for overnight muscle protein synthesis in older men. Neuromuscular electrical stimulation (NMES) as well as presleep dietary protein ingestion represent effective strategies to stimulate muscle protein synthesis rates. Here we demonstrate that in older men after a day of bed rest, the application of NMES prior to presleep protein feeding stimulates the use of

  3. Las organizaciones ¿favorecen o dificultan una práctica enfermera basada en la evidencia?

    Directory of Open Access Journals (Sweden)

    Joan Ernest de Pedro Gómez

    Full Text Available El Artículo pretende desde una mirada crítica reflexionar sobre la posición e influencia de las organizaciones, respecto al desarrollo en la práctica clínica de los cuidados enfermeros. Es mucha la evidencia y son muchas las razones para demandar de las organizaciones, un posicionamiento que favorezca el cambio en los Modelos de Práctica Enfermera (MPE. Dada la influencia que tienen los cuidados en los resultados del proceso clínico (morbi-moratlidad y entendiendo éste como el objetivo de las organizaciones sanitarias, parece lógico intentar que las estructuras organizativas abandonen procesos asistenciales totalmente desfasados, para ofrecer los mejores servicios de salud. Para ello es necesario aplicar los resultados de investigación, tanto en la dotación de enfermeras como en la definición de servicios y cuidados enfermeros. Son las organizaciones las que deben establecer las condiciones para que las Enfermeras actúen en un plano de colaboración con otros profesionales y no de sumisión, posición desde la cual no pueden desarrollar su potencial profesional, el cual resulta necesario para un cambio de la prestación de servicios, adaptando éste a las demandas existentes. Sin la adecuada gestión, encaminada a la utilización del conocimiento enfermero como valor organizacional, será imposible adaptar las necesidades de cuidados a las demandas de servicios. Las organizaciones deben optar por un servicio en el que el MPE permita la inclusión de aquellos resultados de investigación con notables efectos en la calidad de sus procesos, las organizaciones deben asumir la responsabilidad de actuar bajo un modelo, que a todas luces no puede ser otro que el de aplicar en la práctica clínica las evidencias producidas por la investigación.

  4. Experimental Approach for the Uncertainty Assessment of 3D Complex Geometry Dimensional Measurements Using Computed Tomography at the mm and Sub-mm Scales.

    Science.gov (United States)

    Jiménez, Roberto; Torralba, Marta; Yagüe-Fabra, José A; Ontiveros, Sinué; Tosello, Guido

    2017-05-16

    The dimensional verification of miniaturized components with 3D complex geometries is particularly challenging. Computed Tomography (CT) can represent a suitable alternative solution to micro metrology tools based on optical and tactile techniques. However, the establishment of CT systems' traceability when measuring 3D complex geometries is still an open issue. In this work, an alternative method for the measurement uncertainty assessment of 3D complex geometries by using CT is presented. The method is based on the micro-CT system Maximum Permissible Error (MPE) estimation, determined experimentally by using several calibrated reference artefacts. The main advantage of the presented method is that a previous calibration of the component by a more accurate Coordinate Measuring System (CMS) is not needed. In fact, such CMS would still hold all the typical limitations of optical and tactile techniques, particularly when measuring miniaturized components with complex 3D geometries and their inability to measure inner parts. To validate the presented method, the most accepted standard currently available for CT sensors, the Verein Deutscher Ingenieure/Verband Deutscher Elektrotechniker (VDI/VDE) guideline 2630-2.1 is applied. Considering the high number of influence factors in CT and their impact on the measuring result, two different techniques for surface extraction are also considered to obtain a realistic determination of the influence of data processing on uncertainty. The uncertainty assessment of a workpiece used for micro mechanical material testing is firstly used to confirm the method, due to its feasible calibration by an optical CMS. Secondly, the measurement of a miniaturized dental file with 3D complex geometry is carried out. The estimated uncertainties are eventually compared with the component's calibration and the micro manufacturing tolerances to demonstrate the suitability of the presented CT calibration procedure. The 2U/T ratios resulting from the

  5. Decrease of dynamic loads in mobile energy means

    Science.gov (United States)

    Polivaev, O. I.; Gorban, L. K.; Vorohobin, A. V.; Vedrinsky, O. S.

    2018-03-01

    The increase in the productivity of machine and tractor units is possible due to the increase in operating speeds, this leads to the emergence of increased dynamic loads in the system “engine-transmission-propulsion unit-soil”, which worsens the performance of machine-tractor aggregates. To reduce fluctuations in the “engine-transmission” system, special vibration dampers are used, which installed in close proximity to the engine and protect well the transmission from uneven engine operation; however, such dampers practically do not eliminate the oscillations of external loads. Reducing dynamic loads on the transmission and the mobile power engine (MPE) is an important issue directly related to improving the performance, reliability and durability of the tractor, as well as reducing the slippage of the drive wheels. In order to reduce effectively dynamic loads on the transmission and on the MPE, it is necessary to introduce resilient damping elements closer to the sources of oscillations, namely, to the driving wheels. At the same time, the elastic-damping element should provide accumulation of vibration energy caused by external influences and have a large energy capacity. The installation of an elastic-damping element in the final link of the tractor transmission ensures a reduction in the magnitude of external influences, thereby protecting the engine and transmission from large dynamic loads, and allows one to reduce the slippage of the propellers, which has a positive effect on the traction and energy characteristics of the tractor. Traction tests of the LTP-55 tractor on a concrete road showed that the use of an elasto-damping drive makes it possible to increase the maximum tractive power from 33.5 to 35.3 kW and to reduce the slipping of propellers by 12-30%, the specific fuel consumption by 6-10%. When driving on stubble, the use of an elastic-damping drive increases the maximum tractive power from 25 to 26 kW, reduces the skidding of propellers by

  6. Sistema de controle de velocidade sincronizada entre dois veículos agrícolas Synchronized speed control system between two agricultural vehicles

    Directory of Open Access Journals (Sweden)

    Rodrigo Fernando Galzerano Baldo

    2012-02-01

    master tractor speed and registering the slave tractor response. In the first test the slave tractor followed the speed variation simulated with a mean square error (MSE non-significant and a maximum mean percentage error (MPE of 1.3%. In the second test the slave tractor followed the master tractor speed variation with a displacement (MPE ranging in magnitude from 0.2% to 2.9%.

  7. UNA EXPERIENCIA EN LA IMPLEMENTACIÓN DEL SISTEMA DE GESTIÓN DE LA CALIDAD DE UNA EMPRESA DE SERVICIO / AN EXPERIENCE IN THE IMPLEMENTATION OF THE QUALITY MANAGEMENT SYSTEM IN A SERVICE ENTERPRISE

    Directory of Open Access Journals (Sweden)

    Ester Michelena-Fernández

    2011-03-01

    Full Text Available

    El presente artículo muestra un procedimiento para el rediseño e implementación parcial del Sistema de Gestión de la Calidad (SGC de una empresa de servicios. Para llevar a cabo este estudio, se propuso que el objetivo general estuviese encaminado a realizar un rediseño en el SGC con un enfoque a proceso, estableciendo las interrelaciones de las actividades y tareas, así como los procedimientos obligatorios, según establece la Norma ISO 9001-2008. Con el fin de lograr la realización y cumplimiento del objetivo propuesto, se pusieron en práctica métodos y técnicas de diseño y mejoramiento de procesos, como por ejemplo el análisis, síntesis y deducción; además de implementar las metodologías PHVA y MPE de Harrigton (1997 [1]. En la etapa inicial del estudio realizado, se detectó que en el sistema de gestión que utilizaba esta empresa se presentaban un gran número de no conformidades y no cumplía con los requerimientos de la Norma ISO 9001-2008, lo que estaba influyendo negativamente en la calidad de los servicios ofertados y la satisfacción de los requerimientos de los clientes, lo que demostró la necesidad del rediseño del SGC.

    Abstract

    This article presents a procedure for the redesign and partial implementation of the Quality Management System (QMS in a service enterprise. To carry out this study, it was suggested that the main purpose aimed at a redesign of the QMS taking into account a process approach, establishing the interrelation of activities and tasks, as well as mandatory procedures, as established by the ISO 9001-2008 Standard. In order to achieve the completion and implementation of the established purpose, methods and techniques of design and process improvement, such as analysis, synthesis, and deduction, were put into practice, in addition to the implementation of the PDCA methodology and MPE from Harrington (1997 [1]. In the initial stage of study of the management

  8. 24 April 2018: Ordinary General Assembly of the Staff Association!

    CERN Multimedia

    Staff Association

    2018-01-01

    In the first semester of each year, the Staff Association (SA) invites its members to attend and participate in the Ordinary General Assembly (OGA). This year the OGA will be held on Tuesday, 24 April 2018 from 14.00 to 16.00, Main Auditorium, Meyrin (500-1-001). During the Ordinary General Assembly, the activity and financial reports of the SA are presented and submitted for approval to the members. This is the occasion to get a global view on the activities of the SA, its management, and an opportunity to express your opinion, particularly by taking part in votes. Other items are listed on the agenda, as proposed by the Staff Council. Who can vote? Ordinary members (MPE) of the SA can take part in all votes. Associated members (MPA) of the SA and/or affiliated pensioners have a right to vote on those topics that are of direct interest to them. Who can give their opinion, and how? The Ordinary General Assembly is also the opportunity for members of the SA to express themselves through the addition of discus...

  9. 24 April 2018: Ordinary General Assembly of the Staff Association!

    CERN Multimedia

    Staff Association

    2018-01-01

    In the first semester of each year, the Staff Association (SA) invites its members to attend and participate in the Ordinary General Assembly (OGA). This year the OGA will be held on Thursday, 24 April 2018 from 14.00 to 16.00, Main Auditorium, Meyrin (500-1-001). During the Ordinary General Assembly, the activity and financial reports of the SA are presented and submitted for approval to the members. This is the occasion to get a global view on the activities of the SA, its management, and an opportunity to express your opinion, particularly by taking part in votes. Other items are listed on the agenda, as proposed by the Staff Council. Who can vote? Ordinary members (MPE) of the SA can take part in all votes. Associated members (MPA) of the SA and/or affiliated pensioners have a right to vote on those topics that are of direct interest to them. Who can give their opinion, and how? The Ordinary General Assembly is also the opportunity for members of the SA to express themselves through the addition of disc...

  10. 29th June 2017 – Ordinary General Assembly of the Staff Association!

    CERN Document Server

    Staff Association

    2017-01-01

    In the first semester of each year, the Staff Association (SA) invites its members to attend and participate in the Ordinary General Assembly (OGA). This year the OGA will be held on Thursday, 29 June 2017 from 15.30 to 17.30, Main Auditorium, Meyrin (500-1-001). During the Ordinary General Assembly, the activity and financial reports of the SA are presented and submitted for approval to the members. This is the occasion to get a global view on the activities of the SA, its management, and an opportunity to express your opinion, particularly by taking part in votes. Other items are listed on the agenda, as proposed by the Staff Council. Who can vote? Ordinary members (MPE) of the SA can take part in all votes. Associated members (MPA) of the SA and/or affiliated pensioners have a right to vote on those topics that are of direct interest to them. Who can give their opinion, and how? The Ordinary General Assembly is also the opportunity for members of the SA to express themselves through the addition of disc...

  11. Empirical Models For The Correlation With Sunshine Duration of Metrological Data For Tikrit-TuzKhurmato and Kirkuk-IRAQ

    Directory of Open Access Journals (Sweden)

    Fayadh M. Abed Al-Dulaimy

    2012-03-01

    Full Text Available Measurements of metrological data of maximum, minimum ambient temperature, humidity and sunshine duration for a period of 23 years during the period of 1977-2000, at Tikrit (34. 35°N, 43.37°E, TuzKurmato (34.88°N, 44.64°E, and Kirkuk (35.30°N, 44. 21°E, were used to established an Angstrom type corrélation équations for direct global solar radiation. The diffuse radiation was estimated by using klien and Page Models. This calculation appears to be sufficient to discriminate each station from the others due to it’s local characteristic of the sites. The overall results shown for TuzKurmato, the received radiation on the plane surface is higher than Tikrit and Kirkuk while the diffuse radiation reversely behaved as for Tiktit is the highest. The developed model can be used for estimating global solar radiation on horizontal surfaces. The monthly average total solar radiation was estimated. The value of correlation coefficient (r and value of Root Mean Square Error (RMSE, Mean Bias Error (MBE and Mean Percentage Error (MPE were determined for each equation

  12. Point spread function and centroiding accuracy measurements with the JET-X mirror and MOS CCD detector of the Swift gamma ray burst explorer's X-ray telescope

    CERN Document Server

    Ambrosi, R M; Hutchinson, I B; Willingale, R; Wells, A; Short, A D T; Campana, S; Citterio, O; Tagliaferri, G; Burkert, W; Bräuninger, H

    2002-01-01

    The optical components of the Swift X-ray telescope (XRT) are already developed items. They are the flight spare X-ray mirror from the JET-X/Spectrum-X program and an MOS CCD (CCD22) of the type currently operating in orbit as part of the EPIC focal plane camera on XMM-Newton (SPIE 4140 (2000) 64). The JET-X mirrors were first calibrated at the Max Planck Institute for Extraterrestrial Physics' (MPE) Panter facility, Garching, Germany in 1996 (SPIE 2805 (1996) 56; SPIE 3114 (1997) 392). Half-energy widths of 16 arcsec at 1.5 keV were confirmed for the two flight mirrors and the flight spare. The calibration of the flight spare was repeated at Panter in July 2000 in order to establish whether any changes had occurred during the 4 yr that the mirror had been in storage at the OAB, Milan, Italy. The results reported in this paper confirm that the resolution of the JET-X mirrors has remained stable over this storage period. In an extension of this test program, the flight spare EPIC camera was installed at the fo...

  13. Laser Safety and Hazard Analysis for the Trailer (B70) Based AURA Laser System

    International Nuclear Information System (INIS)

    AUGUSTONI, ARNOLD L.

    2003-01-01

    A laser safety and hazard analysis was performed for the AURA laser system based on the 2000 version of the American National Standards Institute's (ANSI) Standard Z136.1, for ''Safe Use of Lasers'' and the 2000 version of the ANSI Standard Z136.6, for ''Safe Use of Lasers Outdoors''. The trailer based AURA laser system is a mobile platform, which is used to perform laser interaction experiments and tests at various national test sites. The trailer (B70) based AURA laser system is generally operated on the United State Air Force Starfire Optical Range (SOR) at Kirtland Air Force Base (KAFB), New Mexico. The laser is used to perform laser interaction testing inside the laser trailer as well as outside the trailer at target sites located at various distances from the exit telescope. In order to protect personnel, who work inside the Nominal Hazard Zone (NHZ), from hazardous laser emission exposures it was necessary to determine the Maximum Permissible Exposure (MPE) for each laser wavelength (wavelength bands) and calculate the appropriate minimum Optical Density (OD min ) of the laser safety eyewear used by authorized personnel and the Nominal Ocular Hazard Distance (NOHD) to protect unauthorized personnel who may have violated the boundaries of the control area and enter into the laser's NHZ

  14. Spatial chaos of Wang tiles with two symbols

    Science.gov (United States)

    Chen, Jin-Yu; Chen, Yu-Jie; Hu, Wen-Guei; Lin, Song-Sun

    2016-02-01

    This investigation completely classifies the spatial chaos problem in plane edge coloring (Wang tiles) with two symbols. For a set of Wang tiles B , spatial chaos occurs when the spatial entropy h ( B ) is positive. B is called a minimal cycle generator if P ( B ) ≠ 0̸ and P ( B ' ) = 0̸ whenever B ' ⫋ B , where P ( B ) is the set of all periodic patterns on ℤ2 generated by B . Given a set of Wang tiles B , write B = C 1 ∪ C 2 ∪ ⋯ ∪ C k ∪ N , where Cj, 1 ≤ j ≤ k, are minimal cycle generators and B contains no minimal cycle generator except those contained in C1∪C2∪⋯∪Ck. Then, the positivity of spatial entropy h ( B ) is completely determined by C1∪C2∪⋯∪Ck. Furthermore, there are 39 equivalence classes of marginal positive-entropy sets of Wang tiles and 18 equivalence classes of saturated zero-entropy sets of Wang tiles. For a set of Wang tiles B , h ( B ) is positive if and only if B contains a MPE set, and h ( B ) is zero if and only if B is a subset of a SZE set.

  15. In Vitro Antioxidant Activities of Phenols and Oleanolic Acid from Mango Peel and Their Cytotoxic Effect on A549 Cell Line

    Directory of Open Access Journals (Sweden)

    Xuelian Bai

    2018-06-01

    Full Text Available Mango peel, the main by-product of juice processing, possesses appreciable quantities of bioactive phenolic compounds and is worthy of further utilization. The present work reports for the first time the HPLC analysis and in vitro antioxidant evaluation of mango peel phenols (MPPs and their cytotoxic effect on the A549 lung cancer cell line. These results indicated that mango peel has the total phenolic content of 723.2 ± 0.93 mg·kg−1 dry mango peel (DMP, which consisted mainly of vanillic aldehyde, caffeic acid, chlorogenic acid, gallic acid, procyanidin B2 and oleanolic acid. Antioxidant assays showed that MPPs had strong antioxidant activities, with 92 ± 4.2% of DPPH radical scavenging rate, 79 ± 2.5% of ABTS radical inhibition rate and 4.7 ± 0.5 μM Trolox equivalents per kg−1 DMP of ferric reducing power. Gallic acid possess a stronger antioxidant capacity than other phenols. In vitro cytotoxic tests suggested that mango peel extract (MPE had an IC50 value of 15 mg·mL−1 and MPPs had a stronger inhibitory effect on the A549 cell line. Oleanolic acid exhibited the strongest cytotoxicity, with an IC50 value of 4.7 μM, which was similar with that of the positive control 5-fluorouracil.

  16. EVE et École

    CERN Multimedia

    Staff Association

    2017-01-01

    Il reste des places disponibles ! La structure Espace de vie enfantine (EVE) et École de l’Association du personnel du CERN vous informe qu’il reste quelques places pour la rentrée scolaire 2017-2018 : à la crèche (2-3 ans) (accueil sur 2, 3 ou 5 jours) ; au jardin d’enfants (2-4 ans) (accueil à la matinée) ; en classe de 1ère primaire (1P) (4-5 ans). N’hésitez pas à rapidement nous contacter si vous êtes intéressés ; nous sommes à votre disposition pour répondre à toutes vos questions : Staff.Kindergarten@cern.ch. L’EVE et École de l’Association du personnel du CERN est ouverte non seulement aux enfants des personnels du CERN (MPE, MPA) mais également aux enfants des personnes ne travaillant pas sur le domaine du CERN. ...

  17. EVE and School: Important announcement

    CERN Multimedia

    Staff Association

    2017-01-01

    Children’s Day-Care Centre (EVE) and School of the CERN Staff Association would like to inform you that there are still a few places available within the structure for the school year 2017–2018, in the: Nursery for 2, 3 or 5 days a week (2- to 3-year-olds); Kindergarten for mornings (2- to 4-year-olds); Primary 1 (1p) class in the School (4- to 5-year-olds). Please get in touch with us quickly if you are interested in any of the available places. We will gladly provide further information and answer any questions you may have: Staff.Kindergarten@cern.ch or (+41) 022 767 36 04 (mornings). EVE and School of the CERN Staff Association welcomes children of CERN Members of Personnel (MPE, MPA), as well as children whose parents do not work on CERN site. We would like to remind you that registrations are also open for the Summer Camp. The camp will run through the four weeks of July from 8.30 am to 5.30 pm with a weekly registration for 450 CHF, lunch included. For more information and regist...

  18. STRATEGI DIVERSIFIKASI PRODUK KAYU OLAHAN Acacia mangium (studi kasus : PT. Musi Hutan Persada

    Directory of Open Access Journals (Sweden)

    Hamzah Hamzah

    2011-08-01

    Full Text Available Normal 0 false false false MicrosoftInternetExplorer4 The objective of this study is to suggest  the best wood  products of Acacia mangium  that have  high value-added as an alternative business and to formulate the fitting  strategy. This study  is descriptive case study applying  purposive sampling method which involved wood product Experts and Senior PT. Musi Hutan Persada Management.  Data have been analyzed through Exponential Compare Method (MPE to select the best product alternative based on eleven set criteria, using AHP method, Hayami value-added Analysis, and Cost Analysis.  The study shows that there are five superior Acacia mangium based products, namely 1 Sawnwood and woodworking (KGKO, 2 Furniture, 3 Medium Density Fibreboard (MDF, 4 Tannin-glue of Acacia mangium  bark and 5 Wood Charcoal.  And  Sawnwood and Woodworking (KGKO, Furniture, and   Tannin-glue  have the best chance.  Best business strategy to be adhered by MHP, “related-diversification”, then is  to continue utilizing  Acacia mangium wood  as renewable resources,  integrated and sustainable business.

  19. Silicon drift detectors coupled to CsI(Tl) scintillators for spaceborne gamma-ray detectors

    International Nuclear Information System (INIS)

    Marisaldi, M.; Fiorini, C.; Labanti, C.; Longoni, A.; Perotti, F.; Rossi, E.; Soltau, H.

    2006-01-01

    Silicon Drift Detectors (SDDs), thanks to their peculiar low noise characteristics, have proven to be excellent photodetectors for CsI(Tl) scintillation light detection. Two basic detector configurations have been developed: either a single SDD or a monolithic array of SDDs coupled to a single CsI(Tl) crystal. A 16 independent detectors prototype is under construction, designed to work in conjunction with the MEGA Compton telescope prototype under development at MPE, Garching, Germany. A single SDD coupled to a CsI(Tl) crystal has also been tested as a monolithic detector with an extended energy range between 1.5 keV and 1 MeV. The SDD is used as a direct X-ray detector for low energy photons interacting in silicon and as a scintillation light photodetector for photons interacting in the crystal. The type of interaction is identified by means of pulse shape discrimination technique. Detectors based on an array of SDDs coupled to a single CsI(Tl) crystal have also been built. The readout of these detectors is based on the Anger camera technique, and submillimeter spatial resolution can be achieved. The two detectors' approaches and their applications will be described

  20. BREXIT

    DEFF Research Database (Denmark)

    Krejsler, John Benedicto

    2016-01-01

    man beholde dette, må man acceptere ’den fri bevægelighed’ inden for EU for arbejdskraft (herunder studerende), varer, tjenesteydelser og kapital. Det bliver sikkert svært at sluge for de brexiteers, der først og fremmest tænkte på mindsket indvandring fra lande som Polen, de baltiske lande og senest...... filosof og sociolog Jürgen Habermas – en af mine helte i denne sammenhæng − har gennem årtier kæmpet for, at EU i stigende grad kunne blive den politiske institutionaliserede kraft, som havde nok tyngde til at matche markedets p.t. alt for ensidige dominans. Dette er kun delvist lykkedes. Mange vil...... formentlig sige, at det er mislykkedes. Der er i alle fald ingen tvivl om, at der stadig er meget at kæmpe for for at skabe mere balance mellem et politisk system med demokratisk og folkelig legitimitet og så det overvejende nyliberalt inspirerede markedsperspektiv, som p.t. dominerer. Men at hævde, at det...

  1. Line spread functions of blazed off-plane gratings operated in the Littrow mounting

    Science.gov (United States)

    DeRoo, Casey T.; McEntaffer, Randall L.; Miles, Drew M.; Peterson, Thomas J.; Marlowe, Hannah; Tutt, James H.; Donovan, Benjamin D.; Menz, Benedikt; Burwitz, Vadim; Hartner, Gisela; Allured, Ryan; Smith, Randall K.; Günther, Ramses; Yanson, Alex; Vacanti, Giuseppe; Ackermann, Marcelo

    2016-04-01

    Future soft x-ray (10 to 50 Å) spectroscopy missions require higher effective areas and resolutions to perform critical science that cannot be done by instruments on current missions. An x-ray grating spectrometer employing off-plane reflection gratings would be capable of meeting these performance criteria. Off-plane gratings with blazed groove facets operating in the Littrow mounting can be used to achieve excellent throughput into orders achieving high resolutions. We have fabricated two off-plane gratings with blazed groove profiles via a technique that uses commonly available microfabrication processes, is easily scaled for mass production, and yields gratings customized for a given mission architecture. Both fabricated gratings were tested in the Littrow mounting at the Max Planck Institute for Extraterrestrial Physics (MPE) PANTER x-ray test facility to assess their performance. The line spread functions of diffracted orders were measured, and a maximum resolution of 800±20 is reported. In addition, we also observe evidence of a blaze effect from measurements of relative efficiencies of the diffracted orders.

  2. Optical and x-ray alignment approaches for off-plane reflection gratings

    Science.gov (United States)

    Allured, Ryan; Donovan, Benjamin D.; DeRoo, Casey T.; Marlowe, Hannah R.; McEntaffer, Randall L.; Tutt, James H.; Cheimets, Peter N.; Hertz, Edward; Smith, Randall K.; Burwitz, Vadim; Hartner, Gisela; Menz, Benedikt

    2015-09-01

    Off-plane reflection gratings offer the potential for high-resolution, high-throughput X-ray spectroscopy on future missions. Typically, the gratings are placed in the path of a converging beam from an X-ray telescope. In the off-plane reflection grating case, these gratings must be co-aligned such that their diffracted spectra overlap at the focal plane. Misalignments degrade spectral resolution and effective area. In-situ X-ray alignment of a pair of off-plane reflection gratings in the path of a silicon pore optics module has been performed at the MPE PANTER beamline in Germany. However, in-situ X-ray alignment may not be feasible when assembling all of the gratings required for a satellite mission. In that event, optical methods must be developed to achieve spectral alignment. We have developed an alignment approach utilizing a Shack-Hartmann wavefront sensor and diffraction of an ultraviolet laser. We are fabricating the necessary hardware, and will be taking a prototype grating module to an X-ray beamline for performance testing following assembly and alignment.

  3. Radiation detectors for use in major public events: classification, requirements, main features, tests and lessons learned

    International Nuclear Information System (INIS)

    Souza, Elder Magalhães de

    2017-01-01

    Since September 11, 2001, we have entered a new terrorism era. The possibility of the use of lost/stolen radioactive materials increases the probability of a radiological threat. The real goal intended with the use of a Radiological Dispersal Device (RRD or dirty bomb) or a Radiation Exposure Device (RDE) could be psychological in nature. Panic in the venues and surrounding area would cause more deaths than the RDD itself, therefore these attempts could cause chaos, injury, fear and terror, the main target of terrorists. The response of the national authorities with the support and aid of the IAEA served as an increase of the capability of detection and identification of nuclear and radiological materials. But this response could not be limited only to the MPE, because if the country has radioactive or nuclear facilities they also should be considered in terms of theft, sabotage, illegal transfer, unauthorized access, and any other malicious acts. In 2007, Rio de Janeiro, received the first Brazilian Major Public Event in this new era. This was the first Brazilian operation which largely utilized detectors (personal radiations detectors -PRD- radiological identification detectors, -RID or RIID- and spectral radiations scanners, -backpacks-, HPGe detectors, car-borne and air-borne systems) to protect the venues, the athletes, the population and the environment. (author)

  4. Factors Associated with the Choice of Peritoneal Dialysis in Patients with End-Stage Renal Disease

    Directory of Open Access Journals (Sweden)

    Pei-Chun Chiang

    2016-01-01

    Full Text Available Background. The purpose of this study was to analyze the factors associated with receiving peritoneal dialysis (PD in patients with incident end-stage renal disease (ESRD in a hospital in Southern Taiwan. Methods. The study included all consecutive patients with incident ESRD who participated in a multidisciplinary predialysis education (MPE program and started their first dialysis therapy between January 1, 2008, and June 30, 2013, in the study hospital. We provided small group teaching sessions to advanced CKD patients and their family to enhance understanding of various dialysis modalities. Multivariate logistic regression models were used to analyze the association of patient characteristics with the chosen dialysis modality. Results. Of the 656 patients, 524 (80% chose hemodialysis and 132 chose PD. Our data showed that young age, high education level, and high scores of activities of daily living (ADLs were positively associated with PD treatment. Patients who received small group teaching sessions had higher percentages of PD treatment (30.5% versus 19.5%; P=0.108 and preparedness for dialysis (61.1% versus 46.6%; P=0.090. Conclusion. Young age, high education level, and high ADL score were positively associated with choosing PD. Early creation of vascular access may be a barrier for PD.

  5. Annex A1: cornerstone of the five-yearly review

    CERN Multimedia

    Staff Association

    2016-01-01

    As a reminder; the purpose of the five-yearly review is to review the financial and social conditions of all CERN personnel whether employed (MPE) or associated (MPA)! In December 2015, the CERN Council approved the package proposed by the Management. Early this year, and as final act of the 2015 five-yearly review, the CERN Council may decide, if necessary and appropriate, to review the procedures defined in Annex A1 and applicable to future five-yearly reviews. At the meeting of TREF (TRipartite Employment Forum)  in early March 2016 discussions will take place between all stakeholders (representatives of Member States, Management and the Staff Association) and Council will take a decision in June 2016, on the basis of the Management's recommendations. What does Annex A1 say and where can I find it? Annex A1 (Article S V 1.02) is a part of the Staff Rules and Regulations. This annex defines: The five-yearly review of the financial and social conditions of the staff, fellows and MPA; The a...

  6. 800 Fellows at CERN: Make your voice heard!

    CERN Multimedia

    Staff Association

    2018-01-01

    The financial and social conditions of the CERN personnel are determined in agreement between the CERN Management and the Staff Association (SA), the statutory body representing the personnel. The Staff Association is mandated to serve and defend the economic, social, professional and moral interests of its members and the entire CERN personnel. Fellows are members of the personnel employed by CERN (MPE), and should be listened to and heard during discussions that concern their financial and social conditions and, more widely, their working and employment conditions. The Staff Association wants to hear from you! At the end of 2017, 50 delegates were elected to the Staff Council, including four fellows. These delegates are your spokespersons within the Staff Association and, as such, they represent you in relations with the Management and the Member States. How can you make a difference? In 2015, during the latest five-yearly review, the aim of which was to review the financial and social conditions of the mem...

  7. Fatores Desarticuladores da Cooperação em Arranjos Produtivos Locais: Um Estudo Quantitativo no APL de Confecções de Tobias Barreto/SE

    Directory of Open Access Journals (Sweden)

    Abimael Magno Do Ouro Filho

    2015-01-01

    Full Text Available Em decorrência do ambiente competitivo e das suas limitações, as micro e pequenas empresas (MPE ́s têm procurado soluções por meio de novas formas de organização como os APLs (Arranjos Produtivos Locais. A maior parte da literatura sobre APL aponta para os fatores motivadores na criação desses arranjos. Entretanto poucos estudos focalizam os fatores que dificultam a cooperação neste tipo de rede. Sob essa perspectiva, o objetivo deste artigo é identificar quais os fatores que influenciam na desarticulaçãoentre os atores do APL de confecções em Tobias Barreto/SE. A pesquisa utilizou o método quantitativo, e foram aplicados 224 questionários a micro e pequenas empresas participantes do APL de Tobias Barreto. Na análise dos dados, foi utilizado o teste de Mann-Whitney para teste de hipóteses, e a regressão logística univariada. Os resultados da pesquisa demonstram que o número de participantes, a falta de confiança entre eles, os conflitos e o aparecimento do comportamento oportunista são fatores que contribuem para a desarticulação entre os atores dos arranjos produtivos locais.

  8. Screening and validation of EXTraS data products

    Science.gov (United States)

    Carpano, Stefania; Haberl, F.; De Luca, A.; Tiengo, A.: Israel, G.; Rodriguez, G.; Belfiore, A.; Rosen, S.; Read, A.; Wilms, J.; Kreikenbohm, A.; Law-Green, D.

    2015-09-01

    The EXTraS project (Exploring the X-ray Transient and variable Sky) is aimed at fullyexploring the serendipitous content of the XMM-Newton EPIC database in the timedomain. The project is funded within the EU/FP7-Cooperation Space framework and is carried out by a collaboration including INAF (Italy), IUSS (Italy), CNR/IMATI (Italy), University of Leicester (UK), MPE (Germany) and ECAP (Germany). The several tasks consist in characterise aperiodicvariability for all 3XMM sources, search for short-term periodic variability on hundreds of thousands sources, detect new transient sources that are missed by standard source detection and hence not belonging to the 3XMM catalogue, search for long term variability by measuring fluxes or upper limits for both pointed and slew observations, and finally perform multiwavelength characterisation andclassification. Screening and validation of the different products is essentially in order to reject flawed results, generated by the automatic pipelines. We present here the screening tool we developed in the form of a Graphical User Interface and our plans for a systematic screening of the different catalogues.

  9. Improving real-time estimation of heavy-to-extreme precipitation using rain gauge data via conditional bias-penalized optimal estimation

    Science.gov (United States)

    Seo, Dong-Jun; Siddique, Ridwan; Zhang, Yu; Kim, Dongsoo

    2014-11-01

    A new technique for gauge-only precipitation analysis for improved estimation of heavy-to-extreme precipitation is described and evaluated. The technique is based on a novel extension of classical optimal linear estimation theory in which, in addition to error variance, Type-II conditional bias (CB) is explicitly minimized. When cast in the form of well-known kriging, the methodology yields a new kriging estimator, referred to as CB-penalized kriging (CBPK). CBPK, however, tends to yield negative estimates in areas of no or light precipitation. To address this, an extension of CBPK, referred to herein as extended conditional bias penalized kriging (ECBPK), has been developed which combines the CBPK estimate with a trivial estimate of zero precipitation. To evaluate ECBPK, we carried out real-world and synthetic experiments in which ECBPK and the gauge-only precipitation analysis procedure used in the NWS's Multisensor Precipitation Estimator (MPE) were compared for estimation of point precipitation and mean areal precipitation (MAP), respectively. The results indicate that ECBPK improves hourly gauge-only estimation of heavy-to-extreme precipitation significantly. The improvement is particularly large for estimation of MAP for a range of combinations of basin size and rain gauge network density. This paper describes the technique, summarizes the results and shares ideas for future research.

  10. A critical review on the estimation of daily global solar radiation from sunshine duration

    International Nuclear Information System (INIS)

    Yorukoglu, Mehmet; Celik, Ali Naci

    2006-01-01

    Models such as the Angstroem-Prescott equation are used to estimate global solar radiation from sunshine duration. In the literature, researchers investigate either the goodness of the model itself or the goodness of the estimation of global solar radiation based on a set of statistical parameters such as R 2 , RMSE, MBE, MABE, MPE and MAPE. If the former is the objective, then the statistical analysis should naturally be based on H/H o - S/S o (the ratio of daily solar radiation to extraterrestrial daily solar radiation vs. the ratio of sunshine duration to day length). If the latter is investigated, then the statistical analysis should be based on H c - H m (calculated daily solar radiation vs. measured daily solar radiation). A literature survey undertaken in the present article showed that these two data sets are apt to be confused, drawing the statistical parameters to be used in assessment of the estimation model from the latter data set or the vice versa set. The statistical parameters are clearly derived from the basics for both of the data sets, and the inconsistencies caused by this confusion and other factors are exposed. A case study of the estimation models and global solar radiation estimation from sunshine duration is presented using five different models (linear, quadratic, cubic, logarithmic and exponential), which are the most common models used in the literature, based on 6 years long measured hourly global solar radiation data

  11. EXTraS: Exploring the X-ray Transient and variable Sky

    Science.gov (United States)

    De Luca, A.; Salvaterra, R.; Tiengo, A.; D'Agostino, D.; Watson, M.; Haberl, F.; Wilms, J.

    2017-10-01

    The EXTraS project extracted all temporal domain information buried in the whole database collected by the EPIC cameras onboard the XMM-Newton mission. This included a search and characterisation of variability, both periodic and aperiodic, in hundreds of thousands of sources spanning more than eight orders of magnitude in time scale and six orders of magnitude in flux, as well as a search for fast transients, missed by standard image analysis. Phenomenological classification of variable sources, based on X-ray and multiwavelength information, has also been performed. All results and products of EXTraS are made available to the scientific community through a web public data archive. A dedicated science gateway will allow scientists to apply EXTraS pipelines on new observations. EXTraS is the most comprehensive analysis of variability, on the largest ever sample of soft X-ray sources. The resulting archive and tools disclose an enormous scientific discovery space to the community, with applications ranging from the search for rare events to population studies, with impact on the study of virtually all astrophysical source classes. EXTraS, funded within the EU/FP7 framework, is carried out by a collaboration including INAF (Italy), IUSS (Italy), CNR/IMATI (Italy), University of Leicester (UK), MPE (Germany) and ECAP (Germany).

  12. Insulin-like growth factor -1 (IGF-1) derived neuropeptides, a novel strategy for the development of pharmaceuticals for managing ischemic brain injury.

    Science.gov (United States)

    Guan, Jian

    2011-08-01

    Insulin-Like Growth Factor-1 (IGF-1) is neuroprotective and improves long-term function after brain injury. However, its clinical application to neurological disorders is limited by its large molecular size, poor central uptake, and mitogenic potential. Glycine-proline-glutamate (GPE) is naturally cleaved from the IGF-1 N-terminal and is also neuroprotective after ischemic injury, thus providing a potential novel strategy of drug discovery for management of neurological disorders. GPE is not enzymatically stable, thus intravenous infusion of GPE becomes necessary for stable and potent neuroprotection. The broad effective dose range and treatment window of 3-7 h after the lesion suggest its potential for treating acute brain injuries. The neuroprotective action of GPE is not age selective, is not dependent on cerebral reperfusion, plasma glucose concentrations, and core body temperature. G-2mPE, a GPE analogue designed to be more resistant to enzymatic activity, has a prolonged plasma half-life and is more potent in neuroprotection. Neuroprotection by GPE and its analogue may be involved in modulation of inflammation, promotion of astrocytosis, inhibition of apoptosis, and in vascular remodeling. Small neuropeptides have advantages over growth factors in the treatment of brain injury, and modified neuropeptides, designed to overcome the limitations of their endogenous counterparts, represent a novel strategy of pharmaceutical discovery for neurological disorders. © 2010 Blackwell Publishing Ltd.

  13. Radiation detectors for use in major public events: classification, requirements, main features, tests and lessons learned

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Elder Magalhães de, E-mail: elder@ird.gov.br [Instituto de Radioproteção e Dosimetria (DIRAD/IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Div. de Radiometria

    2017-07-01

    Since September 11, 2001, we have entered a new terrorism era. The possibility of the use of lost/stolen radioactive materials increases the probability of a radiological threat. The real goal intended with the use of a Radiological Dispersal Device (RRD or dirty bomb) or a Radiation Exposure Device (RDE) could be psychological in nature. Panic in the venues and surrounding area would cause more deaths than the RDD itself, therefore these attempts could cause chaos, injury, fear and terror, the main target of terrorists. The response of the national authorities with the support and aid of the IAEA served as an increase of the capability of detection and identification of nuclear and radiological materials. But this response could not be limited only to the MPE, because if the country has radioactive or nuclear facilities they also should be considered in terms of theft, sabotage, illegal transfer, unauthorized access, and any other malicious acts. In 2007, Rio de Janeiro, received the first Brazilian Major Public Event in this new era. This was the first Brazilian operation which largely utilized detectors (personal radiations detectors -PRD- radiological identification detectors, -RID or RIID- and spectral radiations scanners, -backpacks-, HPGe detectors, car-borne and air-borne systems) to protect the venues, the athletes, the population and the environment. (author)

  14. Analysis of Global Solar Irradiance over Climatic Zones in Nigeria for Solar Energy Applications

    Directory of Open Access Journals (Sweden)

    Adekunle Ayodotun Osinowo

    2015-01-01

    Full Text Available Satellite derived solar irradiance over 25 locations in the 5 climatic zones of Nigeria (tropical rainforest TRF, Guinea savannah GS, Sahel savannah SHS, Sudan savannah SUS, and Mangrove swamp forest MSF was analyzed. To justify its use, the satellite data was tested for goodness of agreement with ground measured solar radiation data using 26-year mean monthly and daily data over 16 locations in the 5 climatic zones. The well-known R2, RMSE, MBE, and MPE statistical tests were used and good agreement was found. The 25 locations were grouped into the 5 climatic zones. Frequency distribution of global solar irradiance was done for each of the climatic zones. This showed that 46.88%, and 40.6% of the number of days (9794 over TRF and MSF, respectively, had irradiation within the range of 15.01–20.01 MJ/m2/day. For the GS, SHS, and SUS, 46.19%, 55.84% and 58.53% of the days had total irradiation within the range of 20.01–25.01 MJ/m2/day, respectively. Generally, in all the climatic zones, coefficients of variation of solar radiation were high and mean values were low in July and August. Contour maps showed that high and low values of global solar irradiance and clearness index were observed in the Northern and Southern locations of Nigeria, respectively.

  15. General Assembly

    CERN Multimedia

    Staff Association

    2016-01-01

    5th April, 2016 – Ordinary General Assembly of the Staff Association! In the first semester of each year, the Staff Association (SA) invites its members to attend and participate in the Ordinary General Assembly (OGA). This year the OGA will be held on Tuesday, April 5th 2016 from 11:00 to 12:00 in BE Auditorium, Meyrin (6-2-024). During the Ordinary General Assembly, the activity and financial reports of the SA are presented and submitted for approval to the members. This is the occasion to get a global view on the activities of the SA, its financial management, and an opportunity to express one’s opinion, including taking part in the votes. Other points are listed on the agenda, as proposed by the Staff Council. Who can vote? Only “ordinary” members (MPE) of the SA can vote. Associated members (MPA) of the SA and/or affiliated pensioners have a right to vote on those topics that are of direct interest to them. Who can give his/her opinion? The Ordinary General Asse...

  16. Moving finite element method for ICF target implosion

    Science.gov (United States)

    Furuta, J.; Kawata, S.; Niu, K.

    1985-03-01

    One dimensional hydrodynamic codes for the analysis of internal confinement fusion (ICF) target implosion which include various effects were developed, but most of them utilize the artificial viscosity (e.g., Von Neumann's viscosity) which cannot reveal accurately the shock waves. A gain of ICF target implosion is much due to the dissipation at the shock fronts, so it is necessary to express correctly the shock waves which are affected by the viscosity. The width of the shock waves is usually a few times as large as the length of mean free path, therefore the meshes for the shock waves must be set to about 10 to the 4th to 10 to the 5th power. It is a serious problem because of the computational memories or CPU time. In the moving finite element (MPE) method, both nodal amplitudes and nodal positions move continuously with time in such a way as to satisfy simultaneous ordinary differential equations (OPDs) which minimize partial differential equation (PDE) residuals.

  17. Proposta de um sistema de suporte executivo para micro e pequenas empresas fundamentado no modelo campos e armas da competição

    Directory of Open Access Journals (Sweden)

    Luciano Silva Gomes

    2010-11-01

    Full Text Available Este artigo objetiva apresentar uma proposta de SSE (Sistema de Suporte Executivo para orientar a formulação de estratégias competitivas para MPE's (Micro e Pequenas Empresas. Para isso, utilizou-se os métodos de pesquisa bibliográfica, por meio do estudo da dissertação de Gomes (2007, que especificou um SI (Sistema de Informação para formulação de estratégias competitivas através do modelo CAC (Campos e Armas da Competição, de Contador (1996, além da engenharia de software para projetar o sistema proposto. Neste trabalho foi constatado que administração estratégica nessas empresas não ocorre de um modo estruturado. Com o objetivo de formalizar este tipo de administração nestas empresas, caracterizando o problema desta pesquisa, este artigo contribui ao projetar um sistema de nível estratégico através da apresentação dos requisitos e funcionalidades necessários para o desenvolvimento de um sistema computacional.

  18. Extracting recurrent scenarios from narrative texts using a Bayesian network: application to serious occupational accidents with movement disturbance.

    Science.gov (United States)

    Abdat, F; Leclercq, S; Cuny, X; Tissot, C

    2014-09-01

    A probabilistic approach has been developed to extract recurrent serious Occupational Accident with Movement Disturbance (OAMD) scenarios from narrative texts within a prevention framework. Relevant data extracted from 143 accounts was initially coded as logical combinations of generic accident factors. A Bayesian Network (BN)-based model was then built for OAMDs using these data and expert knowledge. A data clustering process was subsequently performed to group the OAMDs into similar classes from generic factor occurrence and pattern standpoints. Finally, the Most Probable Explanation (MPE) was evaluated and identified as the associated recurrent scenario for each class. Using this approach, 8 scenarios were extracted to describe 143 OAMDs in the construction and metallurgy sectors. Their recurrent nature is discussed. Probable generic factor combinations provide a fair representation of particularly serious OAMDs, as described in narrative texts. This work represents a real contribution to raising company awareness of the variety of circumstances, in which these accidents occur, to progressing in the prevention of such accidents and to developing an analysis framework dedicated to this kind of accident. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. A simple formula for estimating global solar radiation in central arid deserts of Iran

    International Nuclear Information System (INIS)

    Sabziparvar, Ali A.

    2008-01-01

    Over the last two decades, using simple radiation models has been an interesting task to estimate daily solar radiation in arid and semi-arid deserts such as those in Iran, where the number of solar observation sites is poor. In Iran, most of the models used so far, have been validated for a few specific locations based on short-term solar observations. In this work, three different radiation models (Sabbagh, Paltridge, Daneshyar) have been revised to predict the climatology of monthly average daily solar radiation on horizontal surfaces in various cities in central arid deserts of Iran. The modifications are made by the inclusion of altitude, monthly total number of dusty days and seasonal variation of Sun-Earth distance. A new height-dependent formula is proposed based on MBE, MABE, MPE and RMSE statistical analysis. It is shown that the revised Sabbagh method can be a good estimator for the prediction of global solar radiation in arid and semi-arid deserts with an average error of less than 2%, that performs a more accurate prediction than those in the previous studies. The required data for the suggested method are usually available in most meteorological sites. For the locations, where some of the input data are not reported, an alternative approach is presented. (author)

  20. Hydrology and hydraulics of Cypress Creek watershed, Texas during Hurricane Harvey and Impact of Potential Mitigation Measures.

    Science.gov (United States)

    El Hassan, A.; Fares, A.; Risch, E.

    2017-12-01

    Rain resulting from Hurricane Harvey stated to spread into Harris County late in August 25 and continued until August 31 2017. This high intensity rainfall caused catastrophic flooding across the Greater Houston Area and south Texas. The objectives of this study are to use the USACE Gridded Surface Subsurface Hydrologic Analysis model (GSSHA) to: i) simulate the hydrology and hydraulics of Cypress Creek watershed and quantify the impact of hurricane Harvey on it; and ii) test potential mitigation measures, e.g., construction of a third surface reservoir on the flooding and hydrology of this watershed. Cypress Creek watershed area is 733 km2. Simulations were conducted using precipitation from two sources a) the Multisensory Precipitation Estimator radar products (MPE) and Multi-Radar Multi-Sensor (MRMS) system. Streamflow was downloaded from the USGS gauge at the outlet of the watershed. The models performance using both precipitation data was very reasonable. The construction of an 8 m high embankment at the south central part of the watershed resulted in over 22% reduction of the peak flow of the stream and also reduction of the depth of inundation across the east part of the watershed. These and other mitigation scenarios will be further discussed in details during the presentation.

  1. Possible overexposure of pregnant women to emissions from a walk through metal detector

    International Nuclear Information System (INIS)

    Wu Dagang; Qiang Rui; Chen Ji; Seidman, Seth; Witters, Donald; Kainz, Wolfgang

    2007-01-01

    This paper presents a systematic procedure to evaluate the induced current densities and electric fields due to walk-through metal detector (WTMD) exposure. This procedure is then used to assess the exposure of nine pregnant women models exposed to one WTMD model. First, we measured the magnetic field generated by the WTMD, then we extracted the equivalent current source to represent the WTMD emissions and finally we calculated the induced current densities and electric fields using the impedance method. The WTMD emissions and the induced fields in the pregnant women and fetus models are then compared to the ICNIRP Guidelines and the IEEE C95.6 exposure safety standard. The results prove the consistency between maximum permissible exposure (MPE) levels and basic restrictions for the ICNIRP Guidelines and IEEE C95.6. We also found that this particular WTMD complies with the ICNIRP basic restrictions for month 1-5 models, but leads to both fetus and pregnant women overexposure for month 6-9 models. The IEEE C95.6 restrictions (MPEs and basic restrictions) are not exceeded. The fetus overexposure of this particular WTMD calls for carefully conducted safety evaluations of security systems before they are deployed

  2. Inteligência Competitiva como Suporte à Estratégia Empresarial em Micro e Pequenas Empresas: Um Estudo na Aerotrópole de Belo Horizonte

    Directory of Open Access Journals (Sweden)

    Frederico Cesar Mafra Pereira

    2018-04-01

    Full Text Available O contexto competitivo em que se insere uma empresa pode tornar-se ainda mais impactante quando há fatores ambientais que trazem grandes mudanças ao cenário. A implementação de uma Aerotrópole, que é uma estrutura urbana que tem como centro o aeroporto e, ao redor, atividades relacionadas a ele, demanda um posicionamento empreendedor e inovador das empresas, independentemente do seu porte. Com base em tal afirmativa, o foco deste artigo foi analisar como se configura a Inteligência Competitiva nas MPE da Aerotrópole de Belo Horizonte com vistas à elaboração de suas Estratégias Empresariais. Para alcançar o objetivo do estudo, foi realizada pesquisa do tipo descritiva, com abordagem qualitativa, via triangulação de fontes de coleta e análise de dados. Informalidade na implementação da Inteligência Competitiva e inabilidade na visualização de possibilidades de crescimento foram as características mais marcantes nos resultados obtidos. Há uma relevante oportunidade de melhoria nos processos de gestão das empresas pesquisadas, mostrando a importância da pesquisa realizada para o desenvolvimento econômico da região.

  3. Elections for staff representatives – Join, commit and vote!

    CERN Multimedia

    Staff Association

    2015-01-01

    The Staff Council is a statutory body representing collectively in the area of employment conditions all CERN staff members (MPE and MPA), as well as the pensioners, former Cernois. The Staff Council is the supreme representative body of the CERN staff and pensioners, which defines the main lines of the policy of the Staff Association. The Staff Council is composed of staff representatives (45 seats to represent staff members, and 5 for representing fellows and associate members), as well as delegates for pensioners (seven positions), designated by GAC-EPA. Every two years, the Council is renewed through elections. Concerning the 45 delegates representing staff members, all departments have a least two seats allocated, one in career paths AA to D and one in career paths E to H. This guarantees a fair distribution of seats among the various organizational units and career paths. The table below, shows the exact number of delegates per department and career paths. Staff members or fellows who want to participa...

  4. Intranasal Pharmacokinetic Data for Triptans Such as Sumatriptan and Zolmitriptan Can Render Area Under the Curve (AUC) Predictions for the Oral Route: Strategy Development and Application.

    Science.gov (United States)

    Srinivas, Nuggehally R; Syed, Muzeeb

    2016-01-01

    Limited pharmacokinetic sampling strategy may be useful for predicting the area under the curve (AUC) for triptans and may have clinical utility as a prospective tool for prediction. Using appropriate intranasal pharmacokinetic data, a Cmax vs. AUC relationship was established by linear regression models for sumatriptan and zolmitriptan. The predictions of the AUC values were performed using published mean/median Cmax data and appropriate regression lines. The quotient of observed and predicted values rendered fold-difference calculation. The mean absolute error (MAE), mean positive error (MPE), mean negative error (MNE), root mean square error (RMSE), correlation coefficient (r), and the goodness of the AUC fold prediction were used to evaluate the two triptans. Also, data from the mean concentration profiles at time points of 1 hour (sumatriptan) and 3 hours (zolmitriptan) were used for the AUC prediction. The Cmax vs. AUC models displayed excellent correlation for both sumatriptan (r = .9997; P AUCs (83%-85%) were within 0.76-1.25-fold difference using the regression model. The prediction of AUC values for sumatriptan or zolmitriptan using the concentration data that reflected the Tmax occurrence were in the proximity of the reported values. In summary, the Cmax vs. AUC models exhibited strong correlations for sumatriptan and zolmitriptan. The usefulness of the prediction of the AUC values was established by a rigorous statistical approach.

  5. Kan nye VHS udbrud i regnbueørred forebygges ved vaccination eller avl?

    DEFF Research Database (Denmark)

    Lorenzen, Niels

    laboratoriet ved forskellige temperaturer med godt resultat. En mindre afprøvning under dambrugsforhold har også givet gode resultater. Før det kan komme på tale bruge vaccinen ude, skal den dog godkendes af sundhedsmyndighederne. Egtvedsyge findes i flere lande i Europa og er kendt som en meget tabsvoldende......Tørlægning og desinfektion har traditionelt været brugt til at bekæmpe virussygdommen Egtvedsyge (VHS) i danske ørred-dambrug og lige nu regnes VHS for udryddet. Det har dog vist sig, at der hos vilde fiskebestande i havet findes VHS virus, som under visse omstændigheder må forventes at kunne...... koder for virusets overfladeprotein. Når plasmidet sprøjtes ind i en fisks rygmuskel, vil det blive optaget af en del af muskelcellerne på injektionsstedet, dog uden at plasmidets gener kommer ind i cellernes egne kromosomer. Fidusen er, at disse muskelceller herefter kan lave virusproteinet på samme...

  6. Study on the application of electrothermal atomization atomic absorption spectrometry for the determination of metallic Cu, Pb, Zn, Cd traces in sea water samples

    International Nuclear Information System (INIS)

    Nguyen Thi Kim Dung; Doan Thanh Son; Tran Thi Ngoc Diep

    2004-01-01

    The trace amount of some heavy metallic elements (Cu, Zn, Pb, Cd) in sea water samples were determined directly (without separation) and quantitatively by using Electro-Thermal Atomization Atomic Absorption Spectrometry (ETA-AAS). The effect of mainly major constituents such as Na, Mg, Ca, K, and the mutual effect of the trace elements, which were present in the matrix on the absorption intensity of each analyzed element was studied. The adding of a certain chemical modification for each trace element was also investigated in order to eliminate the overall effect of the background during the pyrolysis and atomization. The sea water sample after fitrating through a membrane with 0.45 μm-hole size was injected in to the graphite tube via an autosampler (MPE50). The absorption intensity of each element was then measured on the VARIO-6 under the optimum parameters for spectrometer such as: maximum wavelength, current of hollow cathode lamp, and that for graphite furnace such as dry temperature, pyrolysis temperature, atomization temperature, ect. The analytical procedures were set-up and applied for the determination of these above mentioned elements in the synthesized sea water sample and in the real sea water samples with high precision and accuracy. (author)

  7. The Joint NASA/Goddard-University of Maryland Research Program in Charged Particle and High Energy Photon Detector Technology

    Science.gov (United States)

    Ipavich, F. M.

    1990-01-01

    The Univ. of Maryland portion investigated the following areas. The Space Physics Group performed studies of data from the AMPTE/CCE spacecraft CHEM experiment and found that the ratio of solar wind to photospheric abundances decreased rather smoothly with the first ionization potential (FIP) of the ion with the low FIP ion being about a factor of two overabundant. Carbon and hydrogen fit this trend particularly well. Several occurrences were analyzed of field aligned beams observed when CCE was upstream of the Earth's bow shock. Also using CHEM data, ring current intensity and composition changes during the main and recovery phases of the great geomagnetic storm that occurred in February 1986 was examined in detail. Still using CHEM data, ring current characteristics were examined in a survey of 20 magnetic storms ranging in size from -50 nT to -312 nT. A study was done of energetic ion anisotropy characteristics in the Earth's magnetosheath region using data from the UMD/MPE experiment on ISEE-1. The properties were analyzed of approx. 30 to 130 keV/e protons and alpha particles upstream of six quasi-parallel interplanetary shocks that passed by the ISEE-3 spacecraft during 1978 to 1979. Work from NASA-Goddard include studies from the High Energy Cosmic Ray Group, Low Energy Cosmic Ray Group, Low Energy Gamma Ray Group, High Energy Astrophysics Theory Group, and the X ray Astronomy Group.

  8. Comparison of chlorzoxazone one-sample methods to estimate CYP2E1 activity in humans

    DEFF Research Database (Denmark)

    Kramer, Iza; Dalhoff, Kim; Clemmesen, Jens O

    2003-01-01

    OBJECTIVE: Comparison of a one-sample with a multi-sample method (the metabolic fractional clearance) to estimate CYP2E1 activity in humans. METHODS: Healthy, male Caucasians ( n=19) were included. The multi-sample fractional clearance (Cl(fe)) of chlorzoxazone was compared with one...... estimates, Cl(est) at 3 h or 6 h, and MR at 3 h, can serve as reliable markers of CYP2E1 activity. The one-sample clearance method is an accurate, renal function-independent measure of the intrinsic activity; it is simple to use and easily applicable to humans.......-time-point clearance estimation (Cl(est)) at 3, 4, 5 and 6 h. Furthermore, the metabolite/drug ratios (MRs) estimated from one-time-point samples at 1, 2, 3, 4, 5 and 6 h were compared with Cl(fe). RESULTS: The concordance between Cl(est) and Cl(fe) was highest at 6 h. The minimal mean prediction error (MPE) of Cl...

  9. Impact of MSD and mask manufacture errors on 45nm-node lithography

    Science.gov (United States)

    Han, Chunying; Li, Yanqiu; Liu, Lihui; Guo, Xuejia; Wang, Xuxia; Yang, Jianhong

    2012-10-01

    Critical Dimension Uniformity (CDU) is quite sensitive in 45nm node lithography and beyond, thus, more attentions should be paid on the controlling of CDU. Moving Standard Deviation (MSD) and Mask Manufacture Errors (MMEs) including the Mask Critical Dimension Error (MCDE), Mask Transmittance Error (MTE) and Mask Phase Error (MPE) are the two important factors influencing CDU. The study on the impact of MSD and MMEs is a helpful way to improve the lithographic quality. Previous researches often emphasize on the single impact of MSD or MMEs, however the impact of both of them usually exists simultaneously. The studies on the co-impact of MSD and MMEs are more significant. In this paper, the impact and the cross-talk between MSD and MMEs on Critical Dimension (CD) and Exposure Latitude verse Depth of Focus (EL-DOF) for different pattern under various illumination conditions have been evaluated by simulation, which is carried on PROLITHTM X3 and in-house software IntLitho. And then, the MSD's tolerance with the existence of MMEs is discussed. The simulation results show that CD error caused by the co-existence of MSD and MMEs is not the simple algebraic sum of the individual CD error caused by MSD or MMEs. The CD error becomes more pronounced when the MSD and MMEs interact with each other. The studies on the tolerance reveal that the tolerance of MSD decreases due to MMEs' existence and mainly depends on the mask pattern's pitch.

  10. Drug release kinetic analysis and prediction of release data via polymer molecular weight in sustained release diltiazem matrices.

    Science.gov (United States)

    Adibkia, K; Ghanbarzadeh, S; Mohammadi, G; Khiavi, H Z; Sabzevari, A; Barzegar-Jalali, M

    2014-03-01

    This study was conducted to investigate the effects of HPMC (K4M and K100M) as well as tragacanth on the drug release rate of diltiazem (DLTZ) from matrix tablets prepared by direct compression method.Mechanism of drug transport through the matrices was studied by fitting the release data to the 10 kinetic models. 3 model independent parameters; i. e., mean dissolution time (MDT), mean release rate (MRR) and release rate efficacy (RE) as well as 5 time point approaches were established to compare the dissolution profiles. To find correlation between fraction of drug released and polymer's molecular weight, dissolution data were fitted into two proposed equations.All polymers could sustain drug release up to 10 h. The release data were fitted best to Peppas and Higuchi square root kinetic models considering squared correlation coefficient and mean percent error (MPE). RE and MRR were decreased when polymer to drug ratio was increased. Conversely, t60% was increased with raising polymer /drug ratio. The fractions of drug released from the formulations prepared with tragacanth were more than those formulated using the same amount of HPMC K4M and HPMC K100M.Preparation of DLTZ matrices applying HPMCK4M, HPMC K100M and tragacanth could effectively extend the drug release. © Georg Thieme Verlag KG Stuttgart · New York.

  11. A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy

    Science.gov (United States)

    Liu, Yang; Ashton, Jeffrey R.; Moding, Everett J.; Yuan, Hsiangkuo; Register, Janna K.; Fales, Andrew M.; Choi, Jaeyeon; Whitley, Melodi J.; Zhao, Xiaoguang; Qi, Yi; Ma, Yan; Vaidyanathan, Ganesan; Zalutsky, Michael R.; Kirsch, David G.; Badea, Cristian T.; Vo-Dinh, Tuan

    2015-01-01

    Nanomedicine has attracted increasing attention in recent years, because it offers great promise to provide personalized diagnostics and therapy with improved treatment efficacy and specificity. In this study, we developed a gold nanostar (GNS) probe for multi-modality theranostics including surface-enhanced Raman scattering (SERS) detection, x-ray computed tomography (CT), two-photon luminescence (TPL) imaging, and photothermal therapy (PTT). We performed radiolabeling, as well as CT and optical imaging, to investigate the GNS probe's biodistribution and intratumoral uptake at both macroscopic and microscopic scales. We also characterized the performance of the GNS nanoprobe for in vitro photothermal heating and in vivo photothermal ablation of primary sarcomas in mice. The results showed that 30-nm GNS have higher tumor uptake, as well as deeper penetration into tumor interstitial space compared to 60-nm GNS. In addition, we found that a higher injection dose of GNS can increase the percentage of tumor uptake. We also demonstrated the GNS probe's superior photothermal conversion efficiency with a highly concentrated heating effect due to a tip-enhanced plasmonic effect. In vivo photothermal therapy with a near-infrared (NIR) laser under the maximum permissible exposure (MPE) led to ablation of aggressive tumors containing GNS, but had no effect in the absence of GNS. This multifunctional GNS probe has the potential to be used for in vivo biosensing, preoperative CT imaging, intraoperative detection with optical methods (SERS and TPL), as well as image-guided photothermal therapy. PMID:26155311

  12. Regular square planer bis-(4,4,4-trifluoro-1-(thiophen-2-yl)butane-1,3-dione)/copper(II) complex: Trans/cis-DFT isomerization, crystal structure, thermal, solvatochromism, hirshfeld surface and DNA-binding analysis

    Science.gov (United States)

    Hema, M. K.; Karthik, C. S.; Warad, Ismail; Lokanath, N. K.; Zarrouk, Abdelkader; Kumara, Karthik; Pampa, K. J.; Mallu, P.

    2018-04-01

    Trans-[Cu(O∩O)2] complex, O∩O = 4,4,4-trifluoro-1-(thiophen-2-yl)butane-1,3-dione was reported with high potential toward CT-DNA binder. The solved XRD-structure of complex indicated a perfect regular square-planer geometry around the Cu(II) center. The trans/cis-DFT-isomerization calculation supported the XRD seen in reflecting the trans-isomer as the kinetic-favor isomer. The desired complex structure was also characterized by conductivity measurement, CHN-elemental analyses, MS, EDX, SEM, UV-Vis., FT-IR, HAS and TG/DTG. The Solvatochromism behavior of the complex was evaluated using four different polar solvents. MPE and Hirshfeld surface analysis (HSA) come to an agreement that fluoride and thiophene protons atoms are with suitable electro-potential environment to form non-classical H-bonds of type CThsbnd H⋯F. The DNA-binding properties were investigated by viscosity tests and spectrometric titrations, the results revealed the complex as strong calf-thymus DNA binder. High intrinsic-binding constants value ∼1.8 × 105 was collected.

  13. A balloon-borne experiment to investigate the Martian magnetic field

    Science.gov (United States)

    Schwingenschuh, K.; Feldhofer, H.; Koren, W.; Jernej, I.; Stachel, M.; Riedler, W.; Slamanig, H.; Auster, H.-U.; Rustenbach, J.; Fornacon, H. K.; Schenk, H. J.; Hillenmaier, O.; Haerendel, G.; Yeroshenko, Ye.; Styashkin, V.; Zaroutzky, A.; Best, A.; Scholz, G.; Russell, C. T.; Means, J.; Pierce, D.; Luhmann, J. G.

    1996-03-01

    The Space Research Institute of the Austrian Academy, of Sciences (Graz, Austria) in cooperation with MPE (Berlin, Germany), GFZ Potsdam (Obs. Niemegk, Germany) IZMIRAN/IOFAN (Moscow, Russian) and IGPP/UCLA (Los Angeles, USA) is designing the magnetic field experiment MAGIBAL (MAGnetic field experiment aboard a martian BALloon) to investigate the magnetic field on the surface of Mars. The dual sensor fluxgate magnetometer is part of the MARS-98/MARS-TOGETHER balloon payload. During a ten days period the balloon will float over a distance of about 2000 km at altitudes between 0 and 4 km. Due to the limited power and telemetry allocation the magnetometer can transmit only one vector per ten seconds and spectral information in the frequency range from 2 - 25 Hz. The dynamic range is +/- 2000 nT. The main scientific objectives of the experiment are: • Determination of the magnetism of the Martian rocks • Investigation of the leakage of the solar wind induced magnetosphere using the correlation between orbiter and balloon observations • Measurement of the magnetic field profile between the orbiter and the surface of Mars during the descent phase of the balloon. Terrestrial test flights with a hot air balloon were performed in order to test the original MAGIBAL equipment under balloon flight conditions.

  14. Genetic and epigenetic markers in colorectal cancer screening: recent advances.

    Science.gov (United States)

    Singh, Manish Pratap; Rai, Sandhya; Suyal, Shradha; Singh, Sunil Kumar; Singh, Nand Kumar; Agarwal, Akash; Srivastava, Sameer

    2017-07-01

    Colorectal cancer (CRC) is a heterogenous disease which develops from benign intraepithelial lesions known as adenomas to malignant carcinomas. Acquired alterations in Wnt signaling, TGFβ, MAPK pathway genes and clonal propagation of altered cells are responsible for this transformation. Detection of adenomas or early stage cancer in asymptomatic patients and better prognostic and predictive markers is important for improving the clinical management of CRC. Area covered: In this review, the authors have evaluated the potential of genetic and epigenetic alterations as markers for early detection, prognosis and therapeutic predictive potential in the context of CRC. We have discussed molecular heterogeneity present in CRC and its correlation to prognosis and response to therapy. Expert commentary: Molecular marker based CRC screening methods still fail to gain trust of clinicians. Invasive screening methods, molecular heterogeneity, chemoresistance and low quality test samples are some key challenges which need to be addressed in the present context. New sequencing technologies and integrated omics data analysis of individual or population cohort results in GWAS. MPE studies following a GWAS could be future line of research to establish accurate correlations between CRC and its risk factors. This strategy would identify most reliable biomarkers for CRC screening and management.

  15. Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging.

    Science.gov (United States)

    Vinegoni, Claudio; Fumene Feruglio, Paolo; Brand, Christian; Lee, Sungon; Nibbs, Antoinette E; Stapleton, Shawn; Shah, Sunil; Gryczynski, Ignacy; Reiner, Thomas; Mazitschek, Ralph; Weissleder, Ralph

    2017-07-01

    The ability to directly image and quantify drug-target engagement and drug distribution with subcellular resolution in live cells and whole organisms is a prerequisite to establishing accurate models of the kinetics and dynamics of drug action. Such methods would thus have far-reaching applications in drug development and molecular pharmacology. We recently presented one such technique based on fluorescence anisotropy, a spectroscopic method based on polarization light analysis and capable of measuring the binding interaction between molecules. Our technique allows the direct characterization of target engagement of fluorescently labeled drugs, using fluorophores with a fluorescence lifetime larger than the rotational correlation of the bound complex. Here we describe an optimized protocol for simultaneous dual-channel two-photon fluorescence anisotropy microscopy acquisition to perform drug-target measurements. We also provide the necessary software to implement stream processing to visualize images and to calculate quantitative parameters. The assembly and characterization part of the protocol can be implemented in 1 d. Sample preparation, characterization and imaging of drug binding can be completed in 2 d. Although currently adapted to an Olympus FV1000MPE microscope, the protocol can be extended to other commercial or custom-built microscopes.

  16. Morphological, rheological and mechanical characterization of polypropylene nanocomposite blends.

    Science.gov (United States)

    Rosales, C; Contreras, V; Matos, M; Perera, R; Villarreal, N; García-López, D; Pastor, J M

    2008-04-01

    In the present work, the effectiveness of styrene/ethylene-butylene/styrene rubbers grafted with maleic anhydride (MA) and a metallocene polyethylene (mPE) as toughening materials in binary and ternary blends with polypropylene and its nanocomposite as continuous phases was evaluated in terms of transmission electron microscopy (TEM), scanning electron microscopy (SEM), oscillatory shear flow and dynamic mechanical thermal analysis (DMA). The flexural modulus and heat distortion temperature values were determined as well. A metallocene polyethylene and a polyamide-6 were used as dispersed phases in these binary and ternary blends produced via melt blending in a corotating twin-screw extruder. Results showed that the compatibilized blends prepared without clay are tougher than those prepared with the nanocomposite of PP as the matrix phase and no significant changes in shear viscosity, melt elasticity, flexural or storage moduli and heat distortion temperature values were observed between them. However, the binary blend with a nanocomposite of PP as matrix and metallocene polyethylene phase exhibited better toughness, lower shear viscosity, flexural modulus, and heat distortion temperature values than that prepared with polyamide-6 as dispersed phase. These results are related to the degree of clay dispersion in the PP and to the type of morphology developed in the different blends.

  17. AWOB: A Collaborative Workbench for Astronomers

    Science.gov (United States)

    Kim, J. W.; Lemson, G.; Bulatovic, N.; Makarenko, V.; Vogler, A.; Voges, W.; Yao, Y.; Kiefl, R.; Koychev, S.

    2015-09-01

    We present the Astronomers Workbench (AWOB1), a web-based collaboration and publication platform for a scientific project of any size, developed in collaboration between the Max-Planck institutes of Astrophysics (MPA) and Extra-terrestrial Physics (MPE) and the Max-Planck Digital Library (MPDL). AWOB facilitates the collaboration between geographically distributed astronomers working on a common project throughout its whole scientific life cycle. AWOB does so by making it very easy for scientists to set up and manage a collaborative workspace for individual projects, where data can be uploaded and shared. It supports inviting project collaborators, provides wikis, automated mailing lists, calendars and event notification and has a built in chat facility. It allows the definition and tracking of tasks within projects and supports easy creation of e-publications for the dissemination of data and images and other resources that cannot be added to submitted papers. AWOB extends the project concept to larger scale consortia, within which it is possible to manage working groups and sub-projects. The existing AWOB instance has so far been limited to Max-Planck members and their collaborators, but will be opened to the whole astronomical community. AWOB is an open-source project and its source code is available upon request. We intend to extend AWOB's functionality also to other disciplines, and would greatly appreciate contributions from the community.

  18. EGFR mutations predict a favorable outcome for malignant pleural effusion of lung adenocarcinoma with Tarceva therapy.

    Science.gov (United States)

    Guo, Haisheng; Wan, Yunyan; Tian, Guangyan; Liu, Qinghua; Kang, Yanmeng; Li, Yuye; Yao, Zhouhong; Lin, Dianjie

    2012-03-01

    The aim of the present study was to evaluate the therapeutic effects and adverse reactions of Tarceva treatment for malignant pleural effusion (MPE) caused by metastatic lung adenocarcinomas. One hundred and twenty-eight patients who failed first-line chemotherapy drug treatment were divided into a mutation and a non-mutation group according to the presence or absence of epidermal growth factor receptor (EGFR) mutations. Each patient received closed drainage combined with simple negative pressure suction after thoracoscopic talc poudrage pleurodesis and oral Tarceva treatment. Short-term and long-term clinical therapeutic effects of Tarceva were evaluated. The EGFR mutation rate in pleural metastatic tissues of lung adenocarcinoma acquired through video-assisted thoracoscopic surgery was higher compared to that in surgical resection specimens, plasma specimens and pleural effusion specimens compared to previously reported results. There were significant statistical differences in the average extubation time (ppleural effusion (ppleural effusion 4 weeks after surgery (ppleural hypertrophy in the mutation group was significantly higher compared to the non-mutation group (ppleural hypertrophy was significantly reduced (ppleural effusion of lung adenocarcinoma with Tarceva therapy. Detection of EGFR mutations may determine the responsiveness of malignant pleural effusion to Tarceva treatment.

  19. Development and blood compatibility assessment of electrospun polyvinyl alcohol blended with metallocene polyethylene and plectranthus amboinicus (PVA/mPE/PA for bone tissue engineering

    Directory of Open Access Journals (Sweden)

    Qi J

    2018-05-01

    Full Text Available Jie Qi,1,* Huang Zhang,2,* Yingzhou Wang,3 Mohan Prasath Mani,4 Saravana Kumar Jaganathan5–7 1Department of Orthopedics, Shaanxi Provincial People’s Hospital, 2Department of Orthopedics, Han Zhong People’s Hospital, Han Zhong, Shaanxi Province, 3Beijing Meinuoyikang Health Food Co., Ltd, Beijing, People’s Republic of China; 4Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Skudai, Johor, Malaysia; 5Department for Management of Science and Technology Development, 6Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam; 7IJN-UTM Cardiovascular Engineering Centre, Department of Clinical Sciences, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Skudai, Johor, Malaysia *These authors contributed equally to this work Introduction: Currently, the design of extracellular matrix (ECM with nanoscale properties in bone tissue engineering is challenging. For bone tissue engineering, the ECM must have certain properties such as being nontoxic, highly porous, and should not cause foreign body reactions. Materials and methods: In this study, the hybrid scaffold based on polyvinyl alcohol (PVA blended with metallocene polyethylene (mPE and plectranthus amboinicus (PA was fabricated for bone tissue engineering via electrospinning. The fabricated hybrid nanocomposites were characterized by scanning electron microscopy (SEM, Fourier transform and infrared spectroscopy (FTIR, thermogravimetric analysis (TGA, contact angle measurement, and atomic force microscopy (AFM. Furthermore, activated partial thromboplastin time (APTT, prothrombin time (PT, and hemolytic assays were used to investigate the blood compatibility of the prepared hybrid nanocomposites. Results: The prepared hybrid nanocomposites showed reduced fiber diameter (238±45 nm and also increased porosity (87% with decreased pore diameter (340±86 nm compared with pure PVA. The interactions between PVA, mPE

  20. Las organizaciones ¿favorecen o dificultan una práctica enfermera basada en la evidencia? Health care organizations: favouring or hindering the practise of evidence based nursing?

    Directory of Open Access Journals (Sweden)

    Joan Ernest de Pedro Gómez

    2004-06-01

    Full Text Available El Artículo pretende desde una mirada crítica reflexionar sobre la posición e influencia de las organizaciones, respecto al desarrollo en la práctica clínica de los cuidados enfermeros. Es mucha la evidencia y son muchas las razones para demandar de las organizaciones, un posicionamiento que favorezca el cambio en los Modelos de Práctica Enfermera (MPE. Dada la influencia que tienen los cuidados en los resultados del proceso clínico (morbi-moratlidad y entendiendo éste como el objetivo de las organizaciones sanitarias, parece lógico intentar que las estructuras organizativas abandonen procesos asistenciales totalmente desfasados, para ofrecer los mejores servicios de salud. Para ello es necesario aplicar los resultados de investigación, tanto en la dotación de enfermeras como en la definición de servicios y cuidados enfermeros. Son las organizaciones las que deben establecer las condiciones para que las Enfermeras actúen en un plano de colaboración con otros profesionales y no de sumisión, posición desde la cual no pueden desarrollar su potencial profesional, el cual resulta necesario para un cambio de la prestación de servicios, adaptando éste a las demandas existentes. Sin la adecuada gestión, encaminada a la utilización del conocimiento enfermero como valor organizacional, será imposible adaptar las necesidades de cuidados a las demandas de servicios. Las organizaciones deben optar por un servicio en el que el MPE permita la inclusión de aquellos resultados de investigación con notables efectos en la calidad de sus procesos, las organizaciones deben asumir la responsabilidad de actuar bajo un modelo, que a todas luces no puede ser otro que el de aplicar en la práctica clínica las evidencias producidas por la investigación.This paper is intended to provide a critical reflection about how organizations influence the nursing clinical practice development. There is an increasing evidence in nursing science and a

  1. STUDI PENINGKATAN KINERJA MANAJEMEN RANTAI PASOK SAYURAN DATARAN TINGGI DI JAWA BARAT Study of Performance Improvement for Highland Vegetables Supply Chain Management in West Java

    Directory of Open Access Journals (Sweden)

    Alim Setiawan S

    2012-05-01

    Model pengukuran kinerja sangat diperlukan sebagai alat untuk peningkatan kinerja rantai pasok sayuran dataran tinggi di Jawa Barat. Pengukuran kinerja dapat mendukung perencanaan tujuan, evaluasi kinerja, perumusan kebijakan strategik, taktis dan operasional rantai pasok. Studi ini dilaksanakan dengan pendekatan sistem yang didukung dengan Teknik/Metode Perbandingan Eksponensial (MPE untuk menyeleksi komoditi prioritas, kombinasi teknik SCOR dan Fuzzy AHP digunakan untuk merancang metrik pengukuran kinerja, Data Envelopment Analysis (DEA untuk pen- gukuran kinerja individu anggota rantai pasok dan analisis SWOT untuk merumuskan strategi peningkatan kinerja ran- tai pasok. Hasil MPE menunjukkan bahwa 3 (tiga komoditas yang diunggulkan adalah Paprika, Lettuce dan Brokoli. Kombinasi SCOR - Fuzzy AHP menghasilkan bobot metrik kinerja rantai pasok: kinerja pengiriman (0,111, Kesesua- ian dengan standar kualitas (0,299, kinerja pemenuhan pesanan (0,182, waktu tunggu pesanan (0.068, pemenuhan siklus pesanan (0,080, fleksibilitas rantai pasok (0,052, biaya manajemen rantai pasok (0,086, siklus pembayaran tunai (0,080, dan stok harian (0.048. Pengukuran kinerja rantai pasok komoditi lettuce dengan teknik DEA menun- jukkan bahwa kinerja efisiensi petani belum mencapai 100 %. Kinerja efisiensi perusahaan pada kasus komoditi lettuce dan sayuran segar potong telah mencapai 100%. Analisa SWOT merekomendasikan strategi untuk peningkatan kinerja rantai pasok lettuce sebagai berikut: 1 penggunaan teknologi hidroponik dan pengurangan penggunaan pestisida, 2 optimasi penjadwalan penanaman dan pemanenan dengan memperhatikan iklim, 3  peningkatan fleksibilitas dalam pemenuhan pesanan, dan 4 penerapan standar manajemen penjaminan kualitas untuk menjamin konsistensi kualitas produk dan penerimaan produk oleh konsumen.

  2. Curvelet-based compressive sensing for InSAR raw data

    Science.gov (United States)

    Costa, Marcello G.; da Silva Pinho, Marcelo; Fernandes, David

    2015-10-01

    The aim of this work is to evaluate the compression performance of SAR raw data for interferometry applications collected by airborne from BRADAR (Brazilian SAR System operating in X and P bands) using the new approach based on compressive sensing (CS) to achieve an effective recovery with a good phase preserving. For this framework is desirable a real-time capability, where the collected data can be compressed to reduce onboard storage and bandwidth required for transmission. In the CS theory, a sparse unknown signals can be recovered from a small number of random or pseudo-random measurements by sparsity-promoting nonlinear recovery algorithms. Therefore, the original signal can be significantly reduced. To achieve the sparse representation of SAR signal, was done a curvelet transform. The curvelets constitute a directional frame, which allows an optimal sparse representation of objects with discontinuities along smooth curves as observed in raw data and provides an advanced denoising optimization. For the tests were made available a scene of 8192 x 2048 samples in range and azimuth in X-band with 2 m of resolution. The sparse representation was compressed using low dimension measurements matrices in each curvelet subband. Thus, an iterative CS reconstruction method based on IST (iterative soft/shrinkage threshold) was adjusted to recover the curvelets coefficients and then the original signal. To evaluate the compression performance were computed the compression ratio (CR), signal to noise ratio (SNR), and because the interferometry applications require more reconstruction accuracy the phase parameters like the standard deviation of the phase (PSD) and the mean phase error (MPE) were also computed. Moreover, in the image domain, a single-look complex image was generated to evaluate the compression effects. All results were computed in terms of sparsity analysis to provides an efficient compression and quality recovering appropriated for inSAR applications

  3. Predicting axillary lymph node metastasis from kinetic statistics of DCE-MRI breast images

    Science.gov (United States)

    Ashraf, Ahmed B.; Lin, Lilie; Gavenonis, Sara C.; Mies, Carolyn; Xanthopoulos, Eric; Kontos, Despina

    2012-03-01

    The presence of axillary lymph node metastases is the most important prognostic factor in breast cancer and can influence the selection of adjuvant therapy, both chemotherapy and radiotherapy. In this work we present a set of kinetic statistics derived from DCE-MRI for predicting axillary node status. Breast DCE-MRI images from 69 women with known nodal status were analyzed retrospectively under HIPAA and IRB approval. Axillary lymph nodes were positive in 12 patients while 57 patients had no axillary lymph node involvement. Kinetic curves for each pixel were computed and a pixel-wise map of time-to-peak (TTP) was obtained. Pixels were first partitioned according to the similarity of their kinetic behavior, based on TTP values. For every kinetic curve, the following pixel-wise features were computed: peak enhancement (PE), wash-in-slope (WIS), wash-out-slope (WOS). Partition-wise statistics for every feature map were calculated, resulting in a total of 21 kinetic statistic features. ANOVA analysis was done to select features that differ significantly between node positive and node negative women. Using the computed kinetic statistic features a leave-one-out SVM classifier was learned that performs with AUC=0.77 under the ROC curve, outperforming the conventional kinetic measures, including maximum peak enhancement (MPE) and signal enhancement ratio (SER), (AUCs of 0.61 and 0.57 respectively). These findings suggest that our DCE-MRI kinetic statistic features can be used to improve the prediction of axillary node status in breast cancer patients. Such features could ultimately be used as imaging biomarkers to guide personalized treatment choices for women diagnosed with breast cancer.

  4. Developing a new solar radiation estimation model based on Buckingham theorem

    Science.gov (United States)

    Ekici, Can; Teke, Ismail

    2018-06-01

    While the value of solar radiation can be expressed physically in the days without clouds, this expression becomes difficult in cloudy and complicated weather conditions. In addition, solar radiation measurements are often not taken in developing countries. In such cases, solar radiation estimation models are used. Solar radiation prediction models estimate solar radiation using other measured meteorological parameters those are available in the stations. In this study, a solar radiation estimation model was obtained using Buckingham theorem. This theory has been shown to be useful in predicting solar radiation. In this study, Buckingham theorem is used to express the solar radiation by derivation of dimensionless pi parameters. This derived model is compared with temperature based models in the literature. MPE, RMSE, MBE and NSE error analysis methods are used in this comparison. Allen, Hargreaves, Chen and Bristow-Campbell models in the literature are used for comparison. North Dakota's meteorological data were used to compare the models. Error analysis were applied through the comparisons between the models in the literature and the model that is derived in the study. These comparisons were made using data obtained from North Dakota's agricultural climate network. In these applications, the model obtained within the scope of the study gives better results. Especially, in terms of short-term performance, it has been found that the obtained model gives satisfactory results. It has been seen that this model gives better accuracy in comparison with other models. It is possible in RMSE analysis results. Buckingham theorem was found useful in estimating solar radiation. In terms of long term performances and percentage errors, the model has given good results.

  5. Numerical modeling of human mastication, a simplistic view to design foods adapted to mastication abilities.

    Science.gov (United States)

    Le Révérend, Benjamin; Hartmann, Christoph

    2014-01-30

    The human diet contains a large variety of aromas, tastes and textures. The latter is particularly important since it determines whether foods are difficult to process orally and thus can be one source of food avoidance. It has also been reported in recent literature that food texture was a main driver for satiation processes and thus it is of interest for the food manufacturing industry to be able to control textural properties of food within the limits of acceptability for the consumer. For solid foods, fracture force is an important aspect of texture and we were interested in understanding the physiological drivers of this variable.We present a third order lever model of human bite force and the space between teeth based on data from the literature on human oral anatomy. The results from the model are compared with experimental data available in the literature. The model compares well with the experimental data (r2 = 0.95, p = 0.0010, MPE = 0.18), and can thus be used to derive a diagram of how food properties such as piece size or fracture force can be used to define whether foods are close to the limits of what the human jaw is capable of breaking. Such modeling tools can be used to define texture rules for tailor-made nutrition for specific populations based on their mastication abilities. The limitations of this modeling approach are also discussed, particularly the fact that tooth shape should also be considered, as this will ultimately define fracture stress, which is the deterministic factor of food fracture.

  6. [Homage to Doctor Theodore Vetter (1916-2004). President of the French Society of the History of Medicine from 1976 to 1978].

    Science.gov (United States)

    Le Minor, Jean-Marie

    2007-01-01

    Théodore Vetter (Strasbourg, 1916, June 19th - 2004, July 8th) was qualified as a medical doctor in medicine in 1948 in Strasbourg, and then followed complementary courses in medical biology in Paris. He realized most of his career as an adviser for medical research in pharmaceutical industry. He presented an early talent for drawing and graphic arts, encouraged by Georges Ritleng (1875-1972), headmaster of the School of decorative arts in Strasbourg. One expression of the artistic gift of Th. Vetter consisted in design and making of ex-libris, field in which he acquired an international reputation. In total, he realized about two hundred ex-libris, mostly for physicians. Also attracted by the history of medicine, he became a member of the Société Française d'Histoire de la Médecine; he was general secretary from 1965 to 1970, then he became vice-president and president from 1976 to 1978. He was the author of about a hundred works concerning the history of medicine; all were characterized by a great rigour and by the direct use of original sources. Among his main works, his studies on the oculist Jacques Daviel (1693-1762), popularizer of the surgery of cataract, on the surgeon Claude Nicolas Le Cat (1700-1768), on the birth of pathology, a commented edition of the complete works of Hippocrates, translated by M.P.E. Littré (1801-1881), and numerous papers on the history of medicine in Strasbourg and Alsace.

  7. Environment 2002. The Norwegian petroleum sector

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    The Ministry of Petroleum and Energy produces an annual environmental review in cooperation with the Norwegian Petroleum Directorate. The purpose of this publication is threefold: (1) to increase knowledge about the environmental aspects of Norwegian oil and gas activities, (2) to take a more detailed look at a specific topic which particularly concerns both the industry and the authorities, and identify the challenges and options faced, (3) to emphasise the governments goal of ensuring that Norway reconciles its role as a large energy producer with a pioneering position on environmental issues. This year's edition focuses on the topic of ''oil and fish - common sea''. Both the petroleum and fishing industries depend on the waters off Norway. Ever since petroleum activities began on the Norwegian continental shelf more than 30 years ago, the authorities have been keen to ensure that these two sectors can work in the same sea areas. What challenges and opportunities face the petroleum industry over discharges to the sea and living marine resources? How can the authorities ensure that this sector is able to coexist with the fisheries? These and similar questions about the relationship between the petroleum and fishing industries in their shared seas are covered in section two of this publication. Environment 2002 also incorporates a factual section, which covers the status of emissions/discharges, environmental impacts and measures to reduce discharges to the sea and emissions to the air from petroleum activities. The MPE hopes that a publication of this kind can enhance basic knowledge about petroleum activities and environmental issues.

  8. Understanding the microbiome: Emerging biomarkers for exploiting the microbiota for personalized medicine against cancer.

    Science.gov (United States)

    Rajpoot, Meenakshi; Sharma, Anil K; Sharma, Anil; Gupta, Girish Kumar

    2018-02-06

    The human body is a home to more than 1 trillion microbes with a diverse variety of commensal microbes that play a crucial role towards the health of the individual. These microbes occupy different habitats such as gut, skin, vagina, oral etc. Not only the types and abundance of microbes are different in different organs, but also these may differ in different individuals. The genome of these microbiota and their ecosystem constitute to form a microbiome. Factors such as diet, environment, host genetics etc. may be the reason behind the wide microbial diversity. A number of studies performed on human microbiome have revealed that microbiota present in healthy and diseased individuals are distinct. Altered microbiome is many a times the reason behind the overexpression of genes which may cause complex diseases including cancer. Manipulation of the human microbiome can be done by microbial supplements such as probiotics or synbiotics, diet or prebiotics and microbial suppression strategies using antibiotics. Recent advances in genome sequencing technologies and metagenomic analysis provide us the broader understanding of these commensal microbes and highlighting the distinctive features of microbiome during healthy and disease states. Molecular pathological epidemiology (MPE) studies have been very helpful in providing insights into the pathological process behind disease evolution and progression by determining the specific etiological factors. New emerging field of research targets the microbiome for therapeutic purposes by which personalized medicines can be made for treating various types of tumors. Screening programmes might be helpful in identifying patients who are at the verge of developing cancer and in delivering appropriate approaches according to individual risk modes so that disease could be prevented. Copyright © 2018 Elsevier Ltd. All rights reserved.

  9. Solar radiation estimation using sunshine hour and air pollution index in China

    International Nuclear Information System (INIS)

    Zhao, Na; Zeng, Xiaofan; Han, Shumin

    2013-01-01

    Highlights: • Aerosol can affect coefficients of A–P equation to estimate solar radiation. • Logarithmic model performed best, according to MBE, MABE, MPE, MAPE, RMSE and NSE. • Parameters of A–P model can be adjusted by API, geographical position and altitude. • A general equation to estimate solar radiation was established in China. - Abstract: Angström–Prescott (A–P) equation is the most widely used empirical relationship to estimate global solar radiation from sunshine hours. A new approach based on Air Pollution Index (API) data is introduced to adjust the coefficients of A–P equation in this study. Based on daily solar radiation, sunshine hours and API data at nine meteorological stations from 2001 to 2011 in China, linear, exponential and logarithmic models are developed and validated. When evaluated by performance indicators of mean bias error, mean absolute bias error, mean percentage error, mean absolute percentage error, root mean square error, and Nash–Sutcliffe Equation, it is demonstrated that logarithmic model performed better than the other models. Then empirical coefficients for three models are given for each station and the variations of these coefficients are affected by API, geographical position, and altitude. This indicates that aerosol can play an important role in estimation solar radiation from sunshine hours, especially in those highly polluted regions. Finally, a countrywide general equation is established based on the sunshine hour data, API and geographical parameters, which can be used to estimate the daily solar radiation in areas where the radiation data is not available

  10. Porcine skin damage thresholds for pulsed nanosecond-scale laser exposure at 1064-nm

    Science.gov (United States)

    DeLisi, Michael P.; Peterson, Amanda M.; Noojin, Gary D.; Shingledecker, Aurora D.; Tijerina, Amanda J.; Boretsky, Adam R.; Schmidt, Morgan S.; Kumru, Semih S.; Thomas, Robert J.

    2018-02-01

    Pulsed high-energy lasers operating in the near-infrared (NIR) band are increasingly being used in medical, industrial, and military applications, but there are little available experimental data to characterize their hazardous effects on skin tissue. The current American National Standard for the Safe Use of Lasers (ANSI Z136.1-2014) defines the maximum permissible exposure (MPE) on the skin as either a single-pulse or total exposure time limit. This study determined the minimum visible lesion (MVL) damage thresholds in Yucatan miniature pig skin for the single-pulse case and several multiple-pulse cases over a wide range of pulse repetition frequencies (PRFs) (10, 125, 2,000, and 10,000 Hz) utilizing nanosecond-scale pulses (10 or 60 ns). The thresholds are expressed in terms of the median effective dose (ED50) based on varying individual pulse energy with other laser parameters held constant. The results confirm a decrease in MVL threshold as PRF increases for exposures with a constant number of pulses, while also noting a PRF-dependent change in the threshold as a function of the number of pulses. Furthermore, this study highlights a change in damage mechanism to the skin from melanin-mediated photomechanical events at high irradiance levels and few numbers of pulses to bulk tissue photothermal additivity at lower irradiance levels and greater numbers of pulses. The observed trends exceeded the existing exposure limits by an average factor of 9.1 in the photothermally-damaged cases and 3.6 in the photomechanicallydamaged cases.

  11. Supra-threshold epidermis injury from near-infrared laser radiation prior to ablation onset

    Science.gov (United States)

    DeLisi, Michael P.; Peterson, Amanda M.; Lile, Lily A.; Noojin, Gary D.; Shingledecker, Aurora D.; Stolarski, David J.; Zohner, Justin J.; Kumru, Semih S.; Thomas, Robert J.

    2017-02-01

    With continued advancement of solid-state laser technology, high-energy lasers operating in the near-infrared (NIR) band are being applied in an increasing number of manufacturing techniques and medical treatments. Safety-related investigations of potentially harmful laser interaction with skin are commonplace, consisting of establishing the maximum permissible exposure (MPE) thresholds under various conditions, often utilizing the minimally-visible lesion (MVL) metric as an indication of damage. Likewise, characterization of ablation onset and velocity is of interest for therapeutic and surgical use, and concerns exceptionally high irradiance levels. However, skin injury response between these two exposure ranges is not well understood. This study utilized a 1070-nm Yb-doped, diode-pumped fiber laser to explore the response of excised porcine skin tissue to high-energy exposures within the supra-threshold injury region without inducing ablation. Concurrent high-speed videography was employed to assess the effect on the epidermis, with a dichotomous response determination given for three progressive damage event categories: observable permanent distortion on the surface, formation of an epidermal bubble due to bounded intra-cutaneous water vaporization, and rupture of said bubble during laser exposure. ED50 values were calculated for these categories under various pulse configurations and beam diameters, and logistic regression models predicted injury events with approximately 90% accuracy. The distinction of skin response into categories of increasing degrees of damage expands the current understanding of high-energy laser safety while also underlining the unique biophysical effects during induced water phase change in tissue. These observations could prove useful in augmenting biothermomechanical models of laser exposure in the supra-threshold region.

  12. Athena Community Office

    Science.gov (United States)

    Martínez-Núnez, S.; Barcons, X.; Barret, D.; Bozzo, E.; Carrera, F. J.; Ceballos, M. T.; Gómez, S.; Monterde, M. P.; Rau, A.

    2017-03-01

    The Athena Community Office (ACO) has been established by ESA's Athena Science Study Team (ASST) in order to obtain support in performing its tasks assigned by ESA, and most specially in the ASST role as "focal point for the interests of the broad scientific community". The ACO is led by the Instituto de Física de Cantabria (CSIC-UC), and its activities are funded by CSIC and UC. Further ACO contributors are the University of Geneva, MPE and IRAP. In this poster, we present ACO to the Spanish Astronomical Community, informing about its main responsibilities, which are: assist the ASST in organising and collecting support from the Athena Working Groups and Topical Panels; organise and maintain the documentation generated by the Athena Working Groups and Topical Panels; manage the Working Group and Topical Panel membership lists; assist the ASST in promoting Athena science capabilities in the research world, through conferences and workshops; keep a record of all papers and presentations related to Athena; support the production of ASST documents; produce and distribute regularly an Athena Newsletter, informing the community about all mission and science developments; create and maintain the Athena Community web portal; maintain an active communication activity; promote, organise and support Athena science-related public outreach, in coordination with ESA and other agencies involved when appropriate; and, design, produce materials and provide pointers to available materials produced by other parties. In summary, ACO is meant to become a focal point to facilitate the scientific exchange between the Athena activities and the scientific community at large, and to disseminate the Athena science objectives to the general public.

  13. Culturable bacterial endophytes isolated from Mangrove tree (Rhizophora apiculata Blume) enhance seedling growth in Rice.

    Science.gov (United States)

    Deivanai, Subramanian; Bindusara, Amitraghata Santhanam; Prabhakaran, Guruswamy; Bhore, Subhash Janardhan

    2014-07-01

    Endophytic bacteria do have several potential applications in medicine and in other various sectors of biotechnology including agriculture. Bacterial endophytes need to be explored for their potential applications in agricultural biotechnology. One of the potential applications of bacterial endophytes in agricultural is to enhance the growth of the agricultural crops. Hence, this study was undertaken to explore the plant growth promoting potential application of bacterial endophytes. The objective of this study was to examine the effect of endophytic bacteria from mangrove tree (Rhizophora apiculata Blume) for their efficacy in promoting seedling growth in rice. Eight endophytic bacterial isolates (EBIs) isolated from twig and petiole tissues of the mangrove were identified based on their 16S ribosomal ribonucleic acid (rRNA) gene sequence homology. Separately, surface sterilized paddy seeds were treated with cell-free broth and cell suspension of the EBIs. Rice seedlings were analyzed by various bioassays and data was recorded. The gene sequences of the isolates were closely related to two genera namely, Bacillus and Pantoea. Inoculation of EBIs from R. apiculata with rice seeds resulted in accelerated root and shoot growth with significant increase in chlorophyll content. Among the isolates, Pantoea ananatis (1MSE1) and Bacillus amyloliquefaciens (3MPE1) had shown predominance of activity. Endophytic invasion was recognized by the non-host by rapid accumulation of reactive oxygen species (ROS) and was counteracted by the production of hydrogen peroxide (H2O2) and lipid peroxide. The results demonstrated that EBIs from mangrove tree can increase the fitness of the rice seedlings under controlled conditions. These research findings could be useful to enhance the seedling growth and could serve as foundation in further research on enhancing the growth of the rice crop using endophytic bacteria.

  14. Anti-Sarcocystis neurona immunostaining associated with equine protozoal myeloencephalitis in Brazil Imunomarcação de Sarcocystis neurona associada com um caso de mieloencefalite protozoária eqüina no Brasil

    Directory of Open Access Journals (Sweden)

    Tatiane Alves da Paixão

    2007-12-01

    Full Text Available A retrospective study (1942 to 2005 of histopathological lesions included samples of central nervous system (SNC from 203 animals in the Equidae family. A total of 42.4% of these samples had significant pathological changes, which were classified as inflammatory (62.8%, degenerative (25.6%, circulatory (10.5%, and neoplasic (1.1% lesions. Immunohistochemistry anti-Sarcocystis neurona antigens was performed in all the cases with inflammatory changes (54, of which one of the case of encephalitis resulted positive to immunostaining. Although evidence of EPM (Equine Protozoal Myeloencephalitis has been previously reported in Brazil, to the best of our knowledge, this is the first report in which characteristic EPM lesion was associated with anti-S. neurona immunostaining in Brazil.Em um estudo retrospectivo (de 1942 a 2005, amostras do sistema nervoso central de 203 eqüídeos foram avaliadas para a presença de alterações histológicas. Dessas amostras, 42,4% apresentaram alguma lesão histopatológica significativa, das quais foram classificadas como alterações inflamatórias (62,8%, degenerativas (25,6%, circulatórias (10,5% e neoplásicas (1,1%. Fragmentos de SNC dos 54 animais com alterações inflamatórias foram avaliados para detecção de antígenos de Sarocystis neurona pela técnica de imunoistoquímica, que foi positiva em um caso de encefalite em eqüino. Embora haja registros de MPE no Brasil, este é o primeiro caso confirmado imunoistoquimicamente.

  15. Comparison of different mass spectrometry techniques in the measurement of L-[ring-13C6]phenylalanine incorporation into mixed muscle proteins

    Science.gov (United States)

    Zabielski, Piotr; Ford, G. Charles; Persson, X. Mai; Jaleel, Abdul; Dewey, Jerry D.; Nair, K Sreekumaran

    2013-01-01

    Precise measurement of low enrichment of stable isotope labeled amino-acid tracers in tissue samples is a prerequisite in measuring tissue protein synthesis rates. The challenge of this analysis is augmented when small sample size is a critical factor. Muscle samples from human participants following an 8 hour intravenous infusion of L-[ring-13C6]phenylalanine and a bolus dose of L-[ring-13C6]phenylalanine in a mouse were utilized. Liquid Chromatography tandem mass spectrometry (LC/MS/MS), Gas Chromatography tandem mass spectrometry (GC/MS/MS) and Gas Chromatography/Mass spectrometry (GC/MS) were compared to the Gas Chromatography-Combustion-Isotope Ratio mass spectrometry (GC/C/IRMS), to measure mixed muscle protein enrichment of [ring13C6]phenylalanine enrichment. The sample isotope enrichment ranged from 0.0091 to 0.1312 Molar Percent excess (MPE). As compared with GC/C/IRMS, LC/MS/MS, GC/MS/MS and GC/MS showed coefficients of determination of R2 = 0.9962 and R2 = 0.9942, and 0.9217 respectively. However, the precision of measurements (coefficients of variation) for intra-assay are 13.0%, 1.7%, 6.3% and 13.5% and for inter-assay are 9.2%, 3.2%, 10.2% and 25% for GC/C/IRMS, LC/MS/MS, GC/MS/MS and GC/MS respectively. The muscle sample sizes required to obtain these results were 8μg, 0.8μg, 3μg and 3μg for GC/C/IRMS, LC/MS/MS, GC/MS/MS, and GC/MS respectively. We conclude that LC/MS/MS is optimally suited for precise measurements of L-[ring-13C6]phenylalanine tracer enrichment in low abundance and in small quantity samples. PMID:23378099

  16. Local sustainable development: proposal of new arrangement for the development of social entrepreneurs Desenvolvimento Local Sustentável: Projeto de novos modos sócio-produtivos e de sistemas alternativos de produção e emprego

    Directory of Open Access Journals (Sweden)

    Takeshy Tachizawa

    2011-03-01

    Full Text Available A diagnosis was developed in the context social and environmental of the city Campo Limpo Paulista and region, for the creation of an incubator destined for the development of social entrepreneurs and technical support to the businessmen of the small sized company. Was based on empirical research carried out in accordance with grounded theory. The present survey there was consulted residents of the region, tourists and made an inventory of the infrastructure of native resources, cultural, historical, economic and social of the city. The results of the inquiry provided subsidies to the projection of the local sustainable development, centered in the creation of a social incubator, of installment of technical services to the entrepreneurs of the region.Desenvolveu-se um diagnóstico no contexto socioambiental de Campo Limpo Paulista e região, para a criação de uma incubadora destinada ao desenvolvimento de empreendedores sociais e suporte técnico aos empresários de micro e pequenas empresas - MPE voltados ao turismo ecológico. Foi baseado em pesquisa empírica realizada de acordo com a grounded theory. Nesta pesquisa foram consultados moradores da região, turistas e efetuado um inventário da infra-estrutura dos recursos naturais, culturais, históricos, econômicos e sociais do município. Os resultados da pesquisa proporcionaram subsídios ao planejamento do desenvolvimento local sustentável, centrado na criação de uma incubadora social, de prestação de serviços técnicos aos empreendedores da região.

  17. Environment 2002. The Norwegian petroleum sector

    International Nuclear Information System (INIS)

    2002-01-01

    The Ministry of Petroleum and Energy produces an annual environmental review in cooperation with the Norwegian Petroleum Directorate. The purpose of this publication is threefold: (1) to increase knowledge about the environmental aspects of Norwegian oil and gas activities, (2) to take a more detailed look at a specific topic which particularly concerns both the industry and the authorities, and identify the challenges and options faced, (3) to emphasise the governments goal of ensuring that Norway reconciles its role as a large energy producer with a pioneering position on environmental issues. This year's edition focuses on the topic of ''oil and fish - common sea''. Both the petroleum and fishing industries depend on the waters off Norway. Ever since petroleum activities began on the Norwegian continental shelf more than 30 years ago, the authorities have been keen to ensure that these two sectors can work in the same sea areas. What challenges and opportunities face the petroleum industry over discharges to the sea and living marine resources? How can the authorities ensure that this sector is able to coexist with the fisheries? These and similar questions about the relationship between the petroleum and fishing industries in their shared seas are covered in section two of this publication. Environment 2002 also incorporates a factual section, which covers the status of emissions/discharges, environmental impacts and measures to reduce discharges to the sea and emissions to the air from petroleum activities. The MPE hopes that a publication of this kind can enhance basic knowledge about petroleum activities and environmental issues

  18. Evaluation of time, attendance of medical staff, and resources during stereotactic radiotherapy/radiosurgery. QUIRO-DEGRO trial

    Energy Technology Data Exchange (ETDEWEB)

    Zabel-du Bois, A.; Milker-Zabel, S.; Debus, J. [Heidelberg Univ. (Germany). Dept. of Radiotherapy and Radiooncology; Henzel, M.; Engenhart-Cabillic, R. [Marburg Univ. (Germany). Dept. of Radiotherapy and Radiation Oncology; Popp, W. [Prime Networks AG, Basel (Switzerland); Sack, H. [Essen Univ. (Germany). Dept. of Radiation Oncology

    2012-09-15

    Background: The German Society of Radiation Oncology ('Deutsche Gesellschaft fuer Radioonkologie', DEGRO) initiated a multicenter trial to develop and evaluate adequate modules to assert core processes and subprocesses in radiotherapy. The aim of this prospective evaluation was to methodical assess the required resources (technical equipment and medical staff) for stereotactic radiotherapy/radiosurgery. Material and methods: At two radiotherapy centers of excellence (University Hospitals of Heidelberg and Marburg/Giessen), the manpower and time required for the implementation of intra- and extracranial stereotactic radiotherapy was prospectively collected consistently over a 3-month period. The data were collected using specifically developed process acquisition tools and standard forms and were evaluated using specific process analysis tools. Results: For intracranial (extracranial) fractionated stereotactic radiotherapy (FSRT) and radiosurgery (RS), a total of 1,925 (270) and 199 (36) records, respectively, could be evaluated. The approximate time needed to customize the immobilization device was median 37 min (89 min) for FRST and 31 min (26 min) for RS, for the contrast enhanced planning studies 22 and 27 min (25 and 28 min), for physical treatment planning 122 and 59 min (187 and 27 min), for the first and routine radiotherapy sessions for FSRT 40 and 13 min (58 and 31 min), respectively. The median time needed for the RS session was 58 min (45 min). The corresponding minimal manpower needed was 2 technicians for customization of the immobilization device, 2.5 technicians and 1 consultant for the contrast-enhanced planning studies, 1 consultant, 0.5 resident and 0.67 medical physics expert (MPE) for physical treatment planning, as well as 1 consultant, 0.5 resident, and 2.5 technicians for the first radiotherapy treatment and 2.33 technicians for routine radiotherapy sessions. Conclusion: For the first time, the resource requirements for a

  19. Blood coagulation parameters and platelet indices: changes in normal and preeclamptic pregnancies and predictive values for preeclampsia.

    Directory of Open Access Journals (Sweden)

    Lei Han

    Full Text Available Preeclampsia (PE is an obstetric disorder with high morbidity and mortality rates but without clear pathogeny. The dysfunction of the blood coagulation-fibrinolysis system is a salient characteristic of PE that varies in severity, and necessitates different treatments. Therefore, it is necessary to find suitable predictors for the onset and severity of PE.We aimed to evaluate blood coagulation parameters and platelet indices as potential predictors for the onset and severity of PE.Blood samples from 3 groups of subjects, normal pregnant women (n = 79, mild preeclampsia (mPE (n = 53 and severe preeclampsia (sPE (n = 42, were collected during early and late pregnancy. The levels of coagulative parameters and platelet indices were measured and compared among the groups. The receiver-operating characteristic (ROC curves of these indices were generated, and the area under the curve (AUC was calculated. The predictive values of the selected potential parameters were examined in binary regression analysis.During late pregnancy in the normal pregnancy group, the activated partial thromboplastin time (APTT, prothrombin time (PT, thrombin time (TT and platelet count decreased, while the fibrinogen level and mean platelet volume (MPV increased compared to early pregnancy (p<0.05. However, the PE patients presented with increased APTT, TT, MPV and D-dimer (DD during the third trimester. In the analysis of subjects with and without PE, TT showed the largest AUC (0.743 and high predictive value. In PE patients with different severities, MPV showed the largest AUC (0.671 and ideal predictive efficiency.Normal pregnancy causes a maternal physiological hypercoagulable state in late pregnancy. PE may trigger complex disorders in the endogenous coagulative pathways and consume platelets and FIB, subsequently activating thrombopoiesis and fibrinolysis. Thrombin time and MPV may serve as early monitoring markers for the onset and severity of PE

  20. Growth models for morphological traits of sunn hemp

    Directory of Open Access Journals (Sweden)

    Cláudia Marques de Bem

    2017-10-01

    Full Text Available The objective of the present study was to fit Gompertz and Logistic nonlinear to descriptions of morphological traits of sunn hemp. Two uniformity trials were conducted and the crops received identical treatment in all experimental area. Sunn hemp seeds were sown in rows 0.5 m apart with a plant density of 20 plants per row meter in a usable area of 52 m × 50 m. The following morphological traits were evaluated: plant height (PH, number of leaves (NL, stem diameter (SD, and root length (RL. These traits were assessed daily during two sowing periods—seeds were sown on October 22, 2014 (first period and December 3, 2014 (second period. Four plants were randomly collected daily, beginning 7 days after first period and 13 days after for second period, totaling 94 and 76 evaluation days, respectively. For Gompertz models the equation was used y=a*e^((?-e?^((b-c*xiand Logistic models the equation was used yi= a/(1+e^((-b-c*xi. The inflection points of the Gompertz and Logistic models were calculated and the goodness of fit was quantified using the adjusted coefficient of determination, Akaike information criterion, standard deviation of residuals, mean absolute deviation, mean absolute percentage error, and mean prediction error. Differences were observed between the Gompertz and Logistic models and between the experimental periods in the parameter estimate for all morphological traits measured. Satisfactory growth curve fittings were achieved for plant height, number of leaves, and stem diameter in both models using the evaluation criteria: coefficient of determination (R², Akaike information criterion (AIC, standard deviation of residuals (SDR, mean absolute deviation (MAD, mean absolute percentage error (MAPE, and mean prediction error (MPE.

  1. Antinociceptive activity of Astragalus gummifer gum (gum tragacanth) through the adrenergic system: A in vivo study in mice.

    Science.gov (United States)

    Bagheri, Seyyed Majid; Keyhani, Leila; Heydari, Mehrangiz; Dashti-R, Mohammad Hossein

    2015-01-01

    In Iranian traditional medicine, gum obtained from Astragalus gummifer and some other species of Astragalus was used as analgesic agent. In this study, we investigated the antinociceptive effect of several concentrations (125, 250, and 500 μg/kg body weight) of Astragalus gummifer gum (AGG) on thermal and acetic acid induced pain in mice. AGG was dissolved in distillated water and injected i.p to male mice 15 minute before the onset of experiment. Writhing and hot-plate tests were applied to study the analgesic effect of AGG and compared with that of diclofenac sodium (30 mg/kg, i.p.) or morphine (8 mg/kg, i.p). To investigate the mechanisms involved in antinociception, yohimbine, naloxone, glibenclamide, and theophylline were used in writhing test. These drugs were injected intraperitoneally 15 min before the administration of AGG. The number of writhes were counted in 30 minutes and analyzed. AGG exhibited a significant antinociceptive effect and the most effective dose of AGG was 500 μg/kg. The most maximum possible effect (%MPE) was observed (117.4%) 15 min after drug administration. The %inhibition of acetic acid-induced writhing in AGG 125, 250 and 500 was 47%, 50% and 54% vs %15 of control and 66.3% of diclofenac sodium group. The antinociceptive effect induced by this gum in the writhing test was reversed by the systemic administration of yohimbine (α2-adrenergic antagonist), but naloxone, glibenclamide, and theophylline did not reverse this effect. The findings of this study indicated that AGG induced its antinociceptive through the adrenergic system.

  2. Antinociceptive activity of Astragalus gummifer gum (gum tragacanth through the adrenergic system: A in vivo study in mice

    Directory of Open Access Journals (Sweden)

    Seyyed Majid Bagheri

    2015-01-01

    Full Text Available Background: In Iranian traditional medicine, gum obtained from Astragalus gummifer and some other species of Astragalus was used as analgesic agent. Objective: In this study, we investigated the antinociceptive effect of several concentrations (125, 250, and 500 μg/kg body weight of Astragalus gummifer gum (AGG on thermal and acetic acid induced pain in mice. Materials and Methods: AGG was dissolved in distillated water and injected i.p to male mice 15 minute before the onset of experiment. Writhing and hot-plate tests were applied to study the analgesic effect of AGG and compared with that of diclofenac sodium (30 mg/kg, i.p. or morphine (8 mg/kg, i.p. To investigate the mechanisms involved in antinociception, yohimbine, naloxone, glibenclamide, and theophylline were used in writhing test. These drugs were injected intraperitoneally 15 min before the administration of AGG. The number of writhes were counted in 30 minutes and analyzed. Results: AGG exhibited a significant antinociceptive effect and the most effective dose of AGG was 500 μg/kg. The most maximum possible effect (%MPE was observed (117.4% 15 min after drug administration. The %inhibition of acetic acid-induced writhing in AGG 125, 250 and 500 was 47%, 50% and 54% vs %15 of control and 66.3% of diclofenac sodium group. The antinociceptive effect induced by this gum in the writhing test was reversed by the systemic administration of yohimbine (α2 -adrenergic antagonist, but naloxone, glibenclamide, and theophylline did not reverse this effect. Conclusions: The findings of this study indicated that AGG induced its antinociceptive through the adrenergic system.

  3. Malignant pleural effusions and the role of talc poudrage and talc slurry: a systematic review and meta-analysis [v2; ref status: indexed, http://f1000r.es/52v

    Directory of Open Access Journals (Sweden)

    Srinivas Mummadi

    2015-02-01

    Full Text Available Background: Malignant Pleural Effusion (MPE is common with advanced malignancy. Palliative care with minimal adverse events is the cornerstone of management. Although talc pleurodesis plays an important role in treatment, the best modality of talc application remains controversial.   Objective: To compare rates of successful pleurodesis, rates of respiratory and non-respiratory complications between thoracoscopic talc insufflation/poudrage (TTI and talc slurry (TS.  Data sources and study selection: MEDLINE (PubMed, OVID,  EBM Reviews (Cochrane database of Systematic Reviews, ACP Journal Club, DARE, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register, Health Technology Assessment and NHS Economic Evaluation Database, EMBASE and Scopus. Randomized controlled trials published between 01/01/1980 - 10/1/2014 and comparing the two strategies were selected.  Results: Twenty-eight potential studies were identified of which 24 studies were further excluded, leaving four studies. No statistically significant difference in the probability of successful pleurodesis was observed between TS and TTI groups (RR 1.06; 95 % CI 0.99-1.14; Q statistic, 4.84. There was a higher risk of post procedural respiratory complications in the TTI group compared to the TS group (RR 1.91, 95% CI= 1.24-2.93, Q statistic 3.15. No statistically significant difference in the incidence of non-respiratory complications between the TTI group and the TS group was observed (RR 0.88, 95% CI= 0.72-1.07, Q statistic 4.61. Conclusions: There is no difference in success rates of pleurodesis based on patient centered outcomes between talc poudrage and talc slurry treatments.  Respiratory complications are more common with talc poudrage via thoracoscopy.

  4. Micro-scale mass-transfer variations during electrodeposition

    Energy Technology Data Exchange (ETDEWEB)

    Sutija, D.P.

    1991-08-01

    Results of two studies on micro-scale mass-transfer enhancement are reported: (1) Profiled cross-sections of striated zinc surfaces deposited in laminar channel flow were analyzed with fast-fourier transforms (FFT) to determine preferred striation wavelengths. Striation frequency increases with current density until a minimum separation between striae of 150 {mu}m is reached. Beyond this point, independent of substrate used, striae meld together and form a relatively smooth, nodular deposit. Substrates equipped with artificial micron-sized protrusions result in significantly different macro-morphology in zinc deposits. Micro-patterned electrodes (MPE) with hemispherical protrusions 5 {mu}m in diameter yield thin zinc striae at current densities that ordinarily produce random nodular deposits. MPEs with artificial hemi-cylinders, 2.5 {mu}m in height and spaced 250 {mu}m apart, form striae with a period which matches the spacing of micron-sized ridges. (2) A novel, corrosion-resistant micromosaic electrode was fabricated on a silicon wafer. Measurements of mass-transport enhancement to a vertical micromosaic electrode caused by parallel bubble streams rising inside of the diffusion boundary-layer demonstrated the presence of two co-temporal enhancement mechanisms: surface-renewal increases the limiting current within five bubble diameters of the rising column, while bubble-induced laminar flows cause weaker enhancement over a much broader swath. The enhancement caused by bubble curtains is predicted accurately by linear superposition of single-column enhancements. Two columns of smaller H{sub 2} bubbles generated at the same volumetric rate as a single column of larger bubbles cause higher peak and far-field enhancements. 168 refs., 96 figs., 6 tabs.

  5. Reducing acquisition risk through integrated systems of systems engineering

    Science.gov (United States)

    Gross, Andrew; Hobson, Brian; Bouwens, Christina

    2016-05-01

    In the fall of 2015, the Joint Staff J7 (JS J7) sponsored the Bold Quest (BQ) 15.2 event and conducted planning and coordination to combine this event into a joint event with the Army Warfighting Assessment (AWA) 16.1 sponsored by the U.S. Army. This multipurpose event combined a Joint/Coalition exercise (JS J7) with components of testing, training, and experimentation required by the Army. In support of Assistant Secretary of the Army for Acquisition, Logistics, and Technology (ASA(ALT)) System of Systems Engineering and Integration (SoSE&I), Always On-On Demand (AO-OD) used a system of systems (SoS) engineering approach to develop a live, virtual, constructive distributed environment (LVC-DE) to support risk mitigation utilizing this complex and challenging exercise environment for a system preparing to enter limited user test (LUT). AO-OD executed a requirements-based SoS engineering process starting with user needs and objectives from Army Integrated Air and Missile Defense (AIAMD), Patriot units, Coalition Intelligence, Surveillance and Reconnaissance (CISR), Focused End State 4 (FES4) Mission Command (MC) Interoperability with Unified Action Partners (UAP), and Mission Partner Environment (MPE) Integration and Training, Tactics and Procedures (TTP) assessment. The SoS engineering process decomposed the common operational, analytical, and technical requirements, while utilizing the Institute of Electrical and Electronics Engineers (IEEE) Distributed Simulation Engineering and Execution Process (DSEEP) to provide structured accountability for the integration and execution of the AO-OD LVC-DE. As a result of this process implementation, AO-OD successfully planned for, prepared, and executed a distributed simulation support environment that responsively satisfied user needs and objectives, demonstrating the viability of an LVC-DE environment to support multiple user objectives and support risk mitigation activities for systems in the acquisition process.

  6. Baryon-Baryon Interactions ---Nijmegen Extended-Soft-Core Models---

    Science.gov (United States)

    Rijken, T. A.; Nagels, M. M.; Yamamoto, Y.

    pseudo-scalar-, vector-, scalar-, and axial-mesons, (ii) diffractive (i.e. multiple-gluon) exchanges, (iii) two pseudo-scalar exchange (PS-PS), and (iv) meson-pair-exchange (MPE). The OBE- and pair-vertices are regulated by gaussian form factors producing potentials with a soft behavior near the origin. The assignment of the cutoff masses for the BBM-vertices is dependent on the SU(3)-classification of the exchanged mesons for OBE, and a similar scheme for MPE. The ESC-models ESC04 and ESC08 describe the nucleon-nucleon (NN), hyperon-nucleon (YN), and hyperon-hyperon (YY) interactions in a unified way using broken SU(3)-symmetry. Novel ingredients in the OBE-sector in the ESC-models are the inclusion of (i) the axial-vector meson potentials, (ii) a zero in the scalar- and axial-vector meson form factors. These innovations made it possible for the first time to keep the meson coupling parameters of the model qualitatively in accordance with the predictions of the (3P_0) quark-antiquark creation (QPC) model. This is also the case for the F/(F+D)-ratios. Furthermore, the introduction of the zero helped to avoid the occurrence of unwanted bound states in Lambda N. Broken SU(3)-symmetry serves to connect the NN and the YN channels, which leaves after fitting NN only a few free parameters for the determination of the YN-interactions. In particular, the meson-baryon coupling constants are calculated via SU(3) using the coupling constants of the NN oplus YN-analysis as input. In ESC04 medium strong flavor-symmetry-breaking (FSB) of the coupling constants was investigated, using the (3}P_{0) -model with a Gell-Mann-Okubo hypercharge breaking for the BBM-coupling. In ESC08 the couplings are kept SU(3)-symmetric. The charge-symmetry-breaking (CSB) in the Lambda p and Lambda n channels, which is an SU(2) isospin breaking, is included in the OBE-, TME-, and MPE-potentials. In ESC04 and ESC08 simultaneous fits to the NN- and the YN- scattering data have been achieved, using different

  7. THE HALO MERGER RATE IN THE MILLENNIUM SIMULATION AND IMPLICATIONS FOR OBSERVED GALAXY MERGER FRACTIONS

    International Nuclear Information System (INIS)

    Genel, Shy; Genzel, Reinhard; Bouche, Nicolas; Naab, Thorsten; Sternberg, Amiel

    2009-01-01

    fair agreement, within the large uncertainties of the observations. Our new halo merger trees are available at http://www.mpe.mpg.de/ir/MillenniumMergerTrees/.

  8. The HST/ACS Coma Cluster Survey. II. Data Description and Source Catalogs

    Science.gov (United States)

    Hammer, Derek; Kleijn, Gijs Verdoes; Hoyos, Carlos; Den Brok, Mark; Balcells, Marc; Ferguson, Henry C.; Goudfrooij, Paul; Carter, David; Guzman, Rafael; Peletier, Reynier F.; hide

    2010-01-01

    The Coma cluster, Abell 1656, was the target of a HST-ACS Treasury program designed for deep imaging in the F475W and F814W passbands. Although our survey was interrupted by the ACS instrument failure in early 2007, the partially-completed survey still covers approximately 50% of the core high density region in Coma. Observations were performed for twenty-five fields with a total coverage area of 274 aremin(sup 2), and extend over a wide range of cluster-centric radii (approximately 1.75 Mpe or 1 deg). The majority of the fields are located near the core region of Coma (19/25 pointings) with six additional fields in the south-west region of the cluster. In this paper we present SEXTRACTOR source catalogs generated from the processed images, including a detailed description of the methodology used for object detection and photometry, the subtraction of bright galaxies to measure faint underlying objects, and the use of simulations to assess the photometric accuracy and completeness of our catalogs. We also use simulations to perform aperture corrections for the SEXTRACTOR Kron magnitudes based only on the measured source flux and its half-light radius. We have performed photometry for 76,000 objects that consist of roughly equal numbers of extended galaxies and unresolved objects. Approximately two-thirds of all detections are brighter than F814W=26.5 mag (AB), which corresponds to the 10sigma, point-source detection limit. We estimate that Coma members are 5-10% of the source detections, including a large population of compact objects (primarily GCs, but also cEs and UCDs), and a wide variety of extended galaxies from cD galaxies to dwarf low surface brightness galaxies. The initial data release for the HST-ACS Coma Treasury program was made available to the public in August 2008. The images and catalogs described in this study relate to our second data release.

  9. Impact of morphologic characteristics of central pulmonary thromboemboli in massive pulmonary embolism.

    Science.gov (United States)

    Podbregar, Matej; Krivec, Bojan; Voga, Gorazd

    2002-09-01

    To assess the impact of morphologically different central pulmonary artery thromboemboli in patients with massive pulmonary emboli (MPEs) on short-term outcome. A prospective registry of consecutive patients. An 11-bed closed medical ICU at a 860-bed community general hospital Forty-seven patients with shock or hypotension due to MPE and central pulmonary thromboemboli detected by transesophageal echocardiography who were treated with thrombolysis between January 1994 and April 2000. Patients were divided into two groups according to the following characteristics of the detected thromboemboli: group 1, thrombi with one or more long, mobile parts; and group 2, immobile thrombi. Right heart catheterization was performed. The incidence of both types of thromboemboli was comparable. Groups 1 and 2 showed no differences in demographic data, risk factors for pulmonary embolism, length of preceding clinical symptoms, percentage of patients in shock, hemodynamic variables, serum lactate levels on hospital admission, and treatment. Seven fatal cases due to obstructive shock and right heart failure were present in group 2, but none were present in group 1 (7 of 23 patients vs 0 of 24 patients, respectively; p < 0.05). At 12 h, the cardiac index was lower in group 2 than in group 1 (2.6 +/- 1.0 vs 3.1 +/- 0.9 L/min/m(2), respectively; p < 0.05), and the central venous pressure (15.0 +/- 6.2 vs 12.5 +/- 3.7 mm Hg, respectively; p < 0.05) and total pulmonary resistance (12.9 +/- 5.9 vs 8.6 +/- 2.7 mm Hg/L/min/m(2), respectively; p < 0.001) were higher in group 2 compared to group 1. On hospital admission, inclusion in group 2 (p < 0.03; hazard ratio, 9.53; 95% confidence interval [CI], 1.19 to 76.47) and preexisting chronic medical or neurologic disease (p < 0.01; hazard ratio, 16.4; 95% CI, 1.97 to 136.3) were independent predictors of 30-day mortality. On hospital admission, morphology of the thromboemboli and the presence of pre-existing chronic medical or neurologic disease

  10. Collagen reorganization at the tumor-stromal interface facilitates local invasion

    Directory of Open Access Journals (Sweden)

    Inman David R

    2006-12-01

    Full Text Available Abstract Background Stromal-epithelial interactions are of particular significance in breast tissue as misregulation of these interactions can promote tumorigenesis and invasion. Moreover, collagen-dense breast tissue increases the risk of breast carcinoma, although the relationship between collagen density and tumorigenesis is not well understood. As little is known about epithelial-stromal interactions in vivo, it is necessary to visualize the stroma surrounding normal epithelium and mammary tumors in intact tissues to better understand how matrix organization, density, and composition affect tumor formation and progression. Methods Epithelial-stromal interactions in normal mammary glands, mammary tumors, and tumor explants in three-dimensional culture were studied with histology, electron microscopy, and nonlinear optical imaging methodologies. Imaging of the tumor-stromal interface in live tumor tissue ex vivo was performed with multiphoton laser-scanning microscopy (MPLSM to generate multiphoton excitation (MPE of endogenous fluorophores and second harmonic generation (SHG to image stromal collagen. Results We used both laser-scanning multiphoton and second harmonic generation microscopy to determine the organization of specific collagen structures around ducts and tumors in intact, unfixed and unsectioned mammary glands. Local alterations in collagen density were clearly seen, allowing us to obtain three-dimensional information regarding the organization of the mammary stroma, such as radiating collagen fibers that could not have been obtained using classical histological techniques. Moreover, we observed and defined three tumor-associated collagen signatures (TACS that provide novel markers to locate and characterize tumors. In particular, local cell invasion was found predominantly to be oriented along certain aligned collagen fibers, suggesting that radial alignment of collagen fibers relative to tumors facilitates invasion. Consistent

  11. 7th International Fermi Symposium

    Science.gov (United States)

    2017-10-01

    especially encourage guest investigators worldwide to participate in this symposium to share results and to learn about upcoming opportunities. This meeting will focus on the new scientific investigations and results enabled by Fermi, the mission and instrument characteristics, future opportunities, coordinated observations and analysis techniques. In particular, we also encourage discussion of future prospects/science with Fermi in preparation for the upcoming NASA senior review. Details on the 7th International Fermi Symposium can be found here: https://events.mpe.mpg.de/Fermi2017

  12. Evaluation of limited sampling models for prediction of oral midazolam AUC for CYP3A phenotyping and drug interaction studies.

    Science.gov (United States)

    Mueller, Silke C; Drewelow, Bernd

    2013-05-01

    The area under the concentration-time curve (AUC) after oral midazolam administration is commonly used for cytochrome P450 (CYP) 3A phenotyping studies. The aim of this investigation was to evaluate a limited sampling strategy for the prediction of AUC with oral midazolam. A total of 288 concentration-time profiles from 123 healthy volunteers who participated in four previously performed drug interaction studies with intense sampling after a single oral dose of 7.5 mg midazolam were available for evaluation. Of these, 45 profiles served for model building, which was performed by stepwise multiple linear regression, and the remaining 243 datasets served for validation. Mean prediction error (MPE), mean absolute error (MAE) and root mean squared error (RMSE) were calculated to determine bias and precision The one- to four-sampling point models with the best coefficient of correlation were the one-sampling point model (8 h; r (2) = 0.84), the two-sampling point model (0.5 and 8 h; r (2) = 0.93), the three-sampling point model (0.5, 2, and 8 h; r (2) = 0.96), and the four-sampling point model (0.5,1, 2, and 8 h; r (2) = 0.97). However, the one- and two-sampling point models were unable to predict the midazolam AUC due to unacceptable bias and precision. Only the four-sampling point model predicted the very low and very high midazolam AUC of the validation dataset with acceptable precision and bias. The four-sampling point model was also able to predict the geometric mean ratio of the treatment phase over the baseline (with 90 % confidence interval) results of three drug interaction studies in the categories of strong, moderate, and mild induction, as well as no interaction. A four-sampling point limited sampling strategy to predict the oral midazolam AUC for CYP3A phenotyping is proposed. The one-, two- and three-sampling point models were not able to predict midazolam AUC accurately.

  13. Applying Improved Multiscale Fuzzy Entropy for Feature Extraction of MI-EEG

    Directory of Open Access Journals (Sweden)

    Ming-ai Li

    2017-01-01

    Full Text Available Electroencephalography (EEG is considered the output of a brain and it is a bioelectrical signal with multiscale and nonlinear properties. Motor Imagery EEG (MI-EEG not only has a close correlation with the human imagination and movement intention but also contains a large amount of physiological or disease information. As a result, it has been fully studied in the field of rehabilitation. To correctly interpret and accurately extract the features of MI-EEG signals, many nonlinear dynamic methods based on entropy, such as Approximate Entropy (ApEn, Sample Entropy (SampEn, Fuzzy Entropy (FE, and Permutation Entropy (PE, have been proposed and exploited continuously in recent years. However, these entropy-based methods can only measure the complexity of MI-EEG based on a single scale and therefore fail to account for the multiscale property inherent in MI-EEG. To solve this problem, Multiscale Sample Entropy (MSE, Multiscale Permutation Entropy (MPE, and Multiscale Fuzzy Entropy (MFE are developed by introducing scale factor. However, MFE has not been widely used in analysis of MI-EEG, and the same parameter values are employed when the MFE method is used to calculate the fuzzy entropy values on multiple scales. Actually, each coarse-grained MI-EEG carries the characteristic information of the original signal on different scale factors. It is necessary to optimize MFE parameters to discover more feature information. In this paper, the parameters of MFE are optimized independently for each scale factor, and the improved MFE (IMFE is applied to the feature extraction of MI-EEG. Based on the event-related desynchronization (ERD/event-related synchronization (ERS phenomenon, IMFE features from multi channels are fused organically to construct the feature vector. Experiments are conducted on a public dataset by using Support Vector Machine (SVM as a classifier. The experiment results of 10-fold cross-validation show that the proposed method yields

  14. ”Er jeg akademiker nok?” – masseuniversitetets studenterkampe om legitim uddannelseskultur

    Directory of Open Access Journals (Sweden)

    Karin Højbjerg

    2015-03-01

    Full Text Available Siden anden verdenskrig er antallet af studerende på videregående uddannelser øget dramatisk. Som noget nyt har også professionsbachelorer adgang til visse af univer¬si-teternes kandidatuddannelser. Dette gælder således for kandidatuddannelsen i Læring og Forandringsprocesser på Aalborg Universitet, hvor denne artikels empiri er genereret fra. Artiklen fremlægger resultaterne af en undersøgelse af, hvordan studerende med forskellige uddannelsesbaggrunde må kæmpe om at definere sig selv og medstuderende som akademikere. Artiklens hovedbegreber er taget fra Pierre Bourdieus praktikteori (Bourdieu, 1996; 1997. Det empiriske materiale består af interviews med otte studerende fra samme årgang på kandidatuddannelsen i Læring og Forandringsprocesser. Materialet er bearbejdet ud fra et Bourdieuinspireret, relationelt blik og er kondenseret ned til fremtrædende træk ved forskelligartede strategier. Artiklen viser eksempler på fire studiestrategier, der relaterer sig til, hvordan man som studerende forholder sig til det at arbejde ”akademisk”: En oprørsstrategi der går mod forestillingen om den dominerende universitetskultur ; en strategi der i udgangspunktet ønsker at inkludere og anerkende andre strategier, men med en oplevelse af at motivationen gradvist forsvinder ; en strategi hvor den studerende aktivt afviser og undgår samarbejde med studerende med bestemte uddannel¬ses¬baggrunde, og endelig en kulturelt opadgående strategi der gradvis er lykkedes med at aflæse den ”akademiske kode". The number of students entering higher education since the Second World War has grown dramatically. As a consequence, students from University Colleges are now given admittance to certain master programmes at the established universities. This article presents the results of a study of how students with different educational backgrounds struggle to define themselves and their fellow students as academics.  In this study we focus on

  15. Giant Black Hole Rips Apart Star

    Science.gov (United States)

    2004-02-01

    Thanks to two orbiting X-ray observatories, astronomers have the first strong evidence of a supermassive black hole ripping apart a star and consuming a portion of it. The event, captured by NASA's Chandra and ESA's XMM-Newton X-ray Observatories, had long been predicted by theory, but never confirmed. Astronomers believe a doomed star came too close to a giant black hole after being thrown off course by a close encounter with another star. As it neared the enormous gravity of the black hole, the star was stretched by tidal forces until it was torn apart. This discovery provides crucial information about how these black holes grow and affect surrounding stars and gas. "Stars can survive being stretched a small amount, as they are in binary star systems, but this star was stretched beyond its breaking point," said Stefanie Komossa of the Max Planck Institute for Extraterrestrial Physics (MPE) in Germany, leader of the international team of researchers. "This unlucky star just wandered into the wrong neighborhood." While other observations have hinted stars are destroyed by black holes (events known as "stellar tidal disruptions"), these new results are the first strong evidence. Evidence already exists for supermassive black holes in many galaxies, but looking for tidal disruptions represents a completely independent way to search for black holes. Observations like these are urgently needed to determine how quickly black holes can grow by swallowing neighboring stars. Animation of Star Ripped Apart by Giant Black Hole Star Ripped Apart by Giant Black Hole Observations with Chandra and XMM-Newton, combined with earlier images from the German Roentgen satellite, detected a powerful X-ray outburst from the center of the galaxy RX J1242-11. This outburst, one of the most extreme ever detected in a galaxy, was caused by gas from the destroyed star that was heated to millions of degrees Celsius before being swallowed by the black hole. The energy liberated in the process

  16. The Most Distant Mature Galaxy Cluster - Young, but surprisingly grown-up

    Science.gov (United States)

    2011-03-01

    information This research was presented in a paper, "A mature cluster with X-ray emission at z = 2.07", by R. Gobat et al., published in the journal Astronomy & Astrophysics. The team is composed of R. Gobat (Laboratoire AIM-Paris-Saclay, France), E. Daddi (AIM-Paris), M. Onodera (ETH Zürich, Switzerland), A. Finoguenov (Max-Planck-Institut für extraterrestrische Physik [MPE], Garching, Germany), A. Renzini (INAF-Osservatorio Astronomico di Padova), N. Arimoto (National Astronomical Observatory of Japan), R. Bouwens (Lick Observatory, Santa Cruz, USA), M. Brusa (MPE), R.-R. Chary (California Institute of Technology, USA), A. Cimatti (Università di Bologna, Italy), M. Dickinson (NOAO, Tucson, USA), X. Kong (University of Science and Technology of China), and M.Mignoli (INAF - Osservatorio Astronomico di Bologna, Italy). ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 15 countries: Austria, Belgium, Brazil, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory and VISTA, the world's largest survey telescope. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a 42-metre European Extremely Large optical/near-infrared Telescope, the E-ELT, which will become "the

  17. "Heart" of Herschel to be presented to media

    Science.gov (United States)

    2007-09-01

    instruments were designed and built by consortia of scientists and institutes, with their own national funding. The Photodetector Array Camera and Spectrometer (PACS) was developed under the coordination of the MPE, Germany; the Spectral and Photometric Imaging Receiver (SPIRE) was developed under the coordination of the Cardiff University (United Kingdom); the Heterodyne Instrument for the Far Infrared (HIFI) was developed under the coordination of the SRON institute (The Netherlands). For more information ESA Media Relations Office Tel: +33(0)1.53.69.7299 Fax: +33(0)1.53.69.7690 Herschel Press Day at Astrium, Friedrichshafen, Germany 19 September 2007 Claude-Dornier-Strasse 88090 Immenstaad 09:00 h Arrival at Astrium /Check-in / Transfer to Building 8 / Room Meersburg (5 th floor) 09:30 h Welcome, by Uwe Minne, Director of Earth Observation and Science, Astrium 09:35 h ESA and Astronomy: looking forward, by Jacques Louet, Head of Scientific Projects Department, ESA 09:45 h Herschel/Planck mission overview, by Thomas Passvogel, ESA Herschel/Planck Project Manager 09:55 h The Herschel scientific mission, by Göran Pilbratt, ESA Herschel Project Scientist 10:05 h Q & A followed by coffee break 10:30 h Herschel spacecraft overview, by Jean-Jacques Julliet, Director of European Science and Optical Observation Programmes, Thales Alenia Space 10:40 h The ‘cool’ heart of Herschel, by Wolfgang Fricke, Herschel Project Manager, Astrium 10:50 h The PACS instrument, by Albrecht Poglitsch, Principal Investigator, Max-Planck-Institut für extraterrestrische Physik (MPE) 11:00 h The SPIRE instrument, by Matthew Griffin, Principal Investigator, Cardiff University 11:10 h The HIFI instrument, by Thijs de Graauw, Principal Investigator, Netherlands Institute for Space Research (SRON) 11:20 h Q & A, Individual Interviews 12:15 h Transfer to Integration Centre 12:30 h Warm / Cold Buffet on Visitoŕs Galaxy Build up of three different visitor groups Check-in into cleanroom Photo

  18. Giant black hole rips star apart

    Science.gov (United States)

    2004-02-01

    Astronomers believe that a doomed star came too close to a giant black hole after a close encounter with another star threw it off course. As it neared the enormous gravity of the black hole, the star was stretched by tidal forces until it was torn apart. This discovery provides crucial information on how these black holes grow and affect the surrounding stars and gas. "Stars can survive being stretched a small amount, as they are in binary star systems, but this star was stretched beyond its breaking point," said Dr Stefanie Komossa of the Max Planck Institute for Extraterrestrial Physics (MPE) in Germany, who led the international team of researchers. "This unlucky star just wandered into the wrong neighbourhood." While other observations have hinted that stars are destroyed by black holes (events known as ‘stellar tidal disruptions’), these new results are the first strong evidence. Observations with XMM-Newton and Chandra, combined with earlier images from the German Roentgensatellite (ROSAT), detected a powerful X-ray outburst from the centre of the galaxy RXJ1242-11. This outburst, one of the most extreme ever detected in a galaxy, was caused by gas from the destroyed star that was heated to millions of degrees before being swallowed by the black hole. The energy liberated in this process is equivalent to that of a supernova. "Now, with all of the data in hand, we have the smoking gun proof that this spectacular event has occurred," said co-author Prof. Guenther Hasinger, also of MPE. The black hole in the centre of RX J1242-11 is estimated to have a mass about 100 million times that of the Sun. By contrast, the destroyed star probably had a mass about equal to that of the Sun, making it a lopsided battle of gravity. "This is the ultimate ‘David versus Goliath’ battle, but here David loses," said Hasinger. The astronomers estimated that about one hundredth of the mass of the star was ultimately consumed, or accreted, by the black hole. This small

  19. Developpement d'un estimateur d'etat energetique d'un chauffe-eau pour un controle par champ moyen

    Science.gov (United States)

    Solis, Jerome

    element. To realize the reconstruction of the continuous state of temperature, two different approaches are considered: the multivariate observer and the Kalman filter. With at most 3 temperature measurements, either in the highest layer of the tank, near the top heating element and the latter at the bottom of the tank of the water heater, a global average error of -440 Wh on all estimated components of the water heater state is obtained by using the multivariate observer, which translates into a global mean percentage error (MPE) of -2.9 % on the energy stocking capacity. Taking advantage of an independent use of the discrete state of the system, the Kalman filter was able to reconstruct the continuous state with a global MPE of -2.0 %, or -270 Wh. For these reasons, the Kalman filter is preferred to the multivariate observer to complete the process of estimating the complete state of the water heater. Moreover, the estimation made by the Kalman filter or the multivariate observer may deviate around +/-10-15 % compared to the total energy stored in the water heater. This thesis presents innovative tools allowing the use of a mean field control strategy in a context of smart grids. This brand new approach presents many challenges and significant improvements can be envisioned, especially for estimating the state of the water heater. Mainly, a more accurate description of the process of extracting hot water, integrating several types of different drawing intensity, allow a more accurate and robust estimation of the hot water drawing sequence.

  20. Reparametrização do modelo baseado na lei de superfície para predição da fração digestível da fibra em detergente neutro em condições brasileiras Reparameterization of the model based on surface law to predict the digestible fraction of neutral detergent fiber in Brazilian cattle

    Directory of Open Access Journals (Sweden)

    Edenio Detmann

    2007-02-01

    cattle using the Surface Law approach. The prediction model used in this study was similar to that proposed by the NRC (2001. The following model parameters were used: lignin protection factor on cell wall carbohydrates (LPF and digestibility coefficient of potentially digestible NDF (DCPNDF. Two estimate sets of these parameters were evaluated. The first set was called Weiss Model (WM and the estimates were 0.75 and 0.667 for DCPNDF and LPF, respectively. The second set was called Corrected Model (CM and the estimate of LPF was 0.85. For the CM the estimates of DCPNDF were obtained by meta-analysis of two trials with lactating cows and four trials with growing and finishing cattle (0.67 and 0.835, respectively. Models were compared by using two experiments of each animal category. Both models predicted similar digestible NDF for lactating cows. The mean prediction errors (MPE were +1.07 and +1.05 percentile points of digestible NDF for WM and CM, respectively. The MPE was lower in CM (+0.42 percentile points than in WM (-6.64 percentile points for growing and finishing cattle. The random fluctuation pattern of the prediction errors was the main limitation of the CM, which might be explained by environmental effects on the interaction between carbohydrates and lignin in the plant cell wall. Although the CM resulted in better estimates than the WM, inclusion of biological methods to estimate potentially digestible NDF may improve the prediction accuracy.

  1. Potencial para implantação da produção mais limpa em sistemas locais de produção: o polo joalheiro de São José do Rio Preto Potential for implantation of cleaner production in local production systems: the jewelry cluster of São José do Rio Preto

    Directory of Open Access Journals (Sweden)

    Rosely Mana Domingues

    2009-12-01

    Full Text Available Os sistemas locais de produção (SLP têm sido foco de políticas e ações nas esferas internacional e nacional voltadas ao desenvolvimento da competitividade da indústria local com base na dinamização de vantagens de aglomeração. Tais ações e políticas apontam os SLP como vetor de dinamismo econômico que favorece o desenvolvimento local, ressaltando o papel de micro e pequenas empresas (MPE organizadas em aglomerações industriais. Porém, verifica-se que, nas análises e nas ações de estruturação e promoção dessas aglomerações, a dimensão ambiental recebe tratamento tangencial. Coloca-se, então, a questão sobre como contemplar a referida dimensão no entendimento e no desenvolvimento dos SLP, incorporando o objetivo de prevenir e reduzir os impactos ambientais negativos oriundos das atividades dessas aglomerações. O artigo tem como objetivo analisar as oportunidades para a integração da dimensão ambiental em um grupo de empresas do Polo Joalheiro de São José do Rio Preto-SP, o segundo maior do Estado de São Paulo em confecção de joias em ouro, participantes de um projeto de competitividade executado pelo Serviço Brasileiro de Apoio às Micro e Pequenas Empresas (SEBRAE. A análise proposta adota a produção mais limpa (P + L como abordagem e ferramenta de gestão ambiental particularmente adequada para empresas de menor porte e podendo convergir com esforços de inovação tecnológica para, desse modo, constituir uma alternativa para a efetivação de melhoria no desempenho ambiental. Por meio de uma pesquisa qualitativa de caráter exploratório, verificou-se que os esforços de atualização tecnológica realizados no polo joalheiro, analisados com base na P + L, permitem a obtenção de benefícios ambientais, econômicos e de saúde e segurança ocupacional a partir da redução no consumo de matérias-primas, água e energia, bem como na geração de resíduos e nas emissões. São identificadas

  2. Charting the Giants

    Science.gov (United States)

    2004-06-01

    the very massive galaxy cluster RXCJ1131.9-1955 at redshift z = 0.306 [3] in a very rich galaxy field with two major concentrations. It was originally found by George Abell and designated "Abell 1300". The image was obtained with the ESO/MPG 2.2-m telescope and the WFI camera at La Silla. ESO PR Photo 18c/04 ESO PR Photo 18c/04 Galaxy Cluster RXCJ0937.9-2020 [Preview - JPEG: 400 x 746 pix - 60k] [Normal - JPEG: 800 x 1491 pix - 1.3M] [HiRes - JPEG: 2380 x 4437 pix - 14.2M] Caption: PR Photo 18c/04 shows the much smaller, more nearby galaxy group RXCJ0937.9-2020 at a redshift of z = 0.034 [3]. It is dominated by the massive elliptical galaxy seen at the top of the image. The photo covers only the southern part of this group. Such galaxy groups with typical masses of a few 1013 solar masses constitute the smallest objects included in the REFLEX catalogue. This image was obtained with the FORS1 multi-mode instrument on the ESO 8.2-m VLT Antu telescope. ESO PR Video Clip 05/04 ESO PR Video Clip 05/04 Galaxy Clusters in the REFLEX Catalogue (3D-visualization) [MPG - 11.7Mb] Caption: ESO PR Video Clip 05/04 illustrates the three-dimensional distribution of the galaxy clusters identfied in the ROSAT All-Sky survey in the northern and southern sky. In addition to the galaxy clusters in the REFLEX catalogue this movie also contains those identified during the ongoing, deeper search for X-ray clusters: the extension of the southern REFLEX Survey and the northern complementary survey that is conducted by the MPE team at the Calar Alto observatory and at US observatories in collaboration with John Huchra and coworkers at the Harvard-Smithonian Center for Astrophysics. In total, more than 1400 X-ray bright galaxy cluster have been found to date. (Prepared by Ferdinand Jamitzky.) Following this idea, a European team of astronomers [2], under the leadership of Hans Böhringer (MPE, Garching, Germany), Luigi Guzzo (INAF, Milano, Italy), Chris A. Collins (JMU, Liverpool), and Peter

  3. XIPE the X-Ray Imaging Polarimetry Explorer

    Science.gov (United States)

    Soffitta, Paolo; Barcons, Xavier; Bellazzini, Ronaldo; Braga, Joao; Costa, Enrico; Fraser, George W.; Gburek, Szymon; Huovelin, Juhani; Matt, Giorgio; Pearce, Mark; hide

    2013-01-01

    .7 arcmin 14.7 arcmin. The spectral resolution is 20 at 6 keV and the time resolution is 8 s. The imaging capabilities of the JET-X optics and of the GPD have been demonstrated by a recent calibration campaign at PANTER X-ray test facility of the Max-Planck-Institut fr extraterrestrische Physik (MPE, Germany). XIPE takes advantage of a low-earth equatorial orbit with Malindi as down-link station and of a Mission Operation Center (MOC) at INPE (Brazil). The data policy is organized with a Core Program that comprises three months of Science Verification Phase and 25 of net observing time in the following 2 years. A competitive Guest Observer program covers the remaining 75 of the net observing time.

  4. Diffuse solar radiation estimation models for Turkey's big cities

    International Nuclear Information System (INIS)

    Ulgen, Koray; Hepbasli, Arif

    2009-01-01

    literature in terms of the widely used statistical indicators, namely; the relative percentage error (E), coefficient of determination (R 2 ), the mean percentage error (MPE), the mean absolute percentage error (MAPE), the sum of the squares of relative errors (SSRE), the relative standard error (RSE), the mean bias error (MBE), the root mean square error (RMSE), and the t-statistic (t-stat) method combining the last two errors. It may be concluded that the new models predict the values of cloudness index (K d ) and diffuse coefficient (K dd ) as a function of clearness index (K T ) and sunshine fraction (S/S o ) for three big cities in Turkey better than other available models, while all the models tested appear to be location independent models for diffuse radiation predictions, at least for three big cities in Turkey. It is also expected that the models reviewed and developed will be beneficial to everyone involved or interested in the design and study of solar energy

  5. Diagnostic utility of serum and pleural fluid carcinoembryonic antigen, and cytokeratin 19 fragments in patients with effusion from nonsmall cell lung cancer

    Directory of Open Access Journals (Sweden)

    Sushil Kumar Sharma

    2015-01-01

    Full Text Available Aims: To assess the diagnostic value of CEA and CYFRA 21-1 (cytokeratin 19 fragments in serum and pleural fluid in non small cell lung cancer with malignant pleural effusion (MPE. Settings and Design: Two subsets of patients were recruited with lymphocytic exudative effusion, one subset constituted diagnosed patients of NSCLC with malignant pleural effusion and the other subset of constituted with Tubercular pleural effusion. Methods and Material : CYFRA 21-1 and CEA levels were measured using Electrochemilumiscence Immunoassay (ECLIA. The test principle used the Sandwich method. For both the tests, results are determined via a calibration curve which is instrument specifically generated by 2 - point calibration and a master curve provided via reagent barcode. Statistical Analysis Used: All data are expressed as means ± SD and percentage. All the parametric variables were analysed by student-t test where as non parametric variables were compared by Mann-Whitney U-test Statistical significance was accepted for P values < 0.05. Software used were SPSS 11.5, and MS excel 2007. In order to compare the performance of the tumor markers, receiver operating characteristic (ROC curves were constructed and compared with area under the curve (AUC. The threshold for each marker was selected based on the best diagnostic efficacy having achieved equilibrium between sensitivity and specificity. Results: In cases serum CYFRA21-1 levels had mean value of 34.1 ± 29.9 with a range of 1.6-128.3 where as in controls serum CYFRA21-1 levels had mean value of 1.9 ± 1.0 with a range of 0.5-4.7. In cases serum CEA levels had mean value of 24.9 ± 47.3 with a range of 1.0, 267.9 where as in controls serum CEA levels had mean value of 1.9 ± 1.4 with a range of 0.2-6.8. The difference in the means of serum CYFRA 21-l (P = 0.000 and CEA (P = 0.046 were statistically significant. In cases pleural fluid CYFRA21-1 levels had mean value of 160.1 ± 177.1 with a range of 5

  6. Chandra Captures Venus In A Whole New Light

    Science.gov (United States)

    2001-11-01

    Scientists have captured the first X-ray view of Venus using NASA's Chandra X-ray Observatory. The observations provide new information about the atmosphere of Venus and open a new window for examining Earth's sister planet. Venus in X-rays looks similar to Venus in visible light, but there are important differences. The optically visible Venus is due to the reflection of sunlight and, for the relative positions of Venus, Earth and Sun during these observations, shows a uniform half-crescent that is brightest toward the middle. The X-ray Venus is slightly less than a half-crescent and brighter on the limbs. The differences are due to the processes by which Venus shines in visible and X-ray light. The X-rays from Venus are produced by fluorescence, rather than reflection. Solar X-rays bombard the atmosphere of Venus, knock electrons out of the inner parts of the atoms, and excite the atoms to a higher energy level. The atoms almost immediately return to their lower energy state with the emission of a fluorescent X-ray. A similar process involving ultraviolet light produces the visible light from fluorescent lamps. For Venus, most of the fluorescent X-rays come from oxygen and carbon atoms between 120 and 140 kilometers (74 to 87 miles) above the planet's surface. In contrast, the optical light is reflected from clouds at a height of 50 to 70 kilometers (31 to 43 miles). As a result, Venus' Sun-lit hemisphere appears surrounded by an almost-transparent luminous shell in X-rays. Venus looks brightest at the limb since more luminous material is there. Venus X-ray/Optical Composite of Venus Credit: Xray: NASA/CXC/MPE/K.Dennerl et al., Optical: Konrad Dennerl "This opens up the exciting possibility of using X-ray observations to study regions of the atmosphere of Venus that are difficult to investigate by other means," said Konrad Dennerl of the Max Planck Institute for Extraterrestrial Physics in Garching, Germany, leader of an international team of scientists that

  7. SUBJECT AND AUTHOR INDEXS

    Directory of Open Access Journals (Sweden)

    IJBE Volume 2

    2016-09-01

    Full Text Available SUBJECT INDEX IJBE VOLUME 2access credit, 93acquisition, 177AHP, 61, 82, 165arena simulation,43BMC, 69Bojonegoro, 69brand choice, 208brand image, 208brand positioning, 208bullwhip effect, 43burger buns, 1business synergy and financial reports, 177capital structure, 130cluster, 151coal reserves, 130coffee plantation, 93competitiveness, 82consumer behaviour, 33consumer complaint behavior, 101cooking spices, 1crackers, 1cross sectional analytical, 139crosstab, 101CSI, 12direct selling, 122discriminant analysis, 33economic value added, 130, 187employee motivation, 112employee performance, 112employees, 139EOQ, 23farmer decisions, 93farmer group, 52financial performance evaluation, 187financial performance, 52, 177financial ratio, 187financial report, 187fiva food, 23food crops, 151horticulture, 151imports, 151improved capital structure, 177IPA, 12leading sector, 151life insurance, 165LotteMart, 43main product, 61marketing mix, 33, 165matrix SWOT, 69MPE, 61multiple linear regression, 122muslim clothing, 197Ogun, 139Pangasius fillet, 82Pati, 93pearson correlation, 101perceived value, 208performance suppy chain, 23PLS, 208POQ, 23portfolio analyzing, 1product, 101PT SKP, 122pulp and papers, 187purchase decision, 165purchase intention, 33remuneration, 112re-purchasing decisions, 197sales performance, 122sawmill, 52SCOR, 23sekolah peternakan rakyat, 69SEM, 112SERVQUAL, 12Sido Makmur farmer groups, 93SI-PUHH Online, 12small and medium industries (IKM, 61socio-demographic, 139sport drink, 208stress, 139supply chain, 43SWOT, 82the mix marketing, 197Tobin’s Q, 130trade partnership, 52uleg chili sauce, 1 AUTHOR INDEX IJBE VOLUME 2Achsani, Noer Azam, 177Andati, Trias, 52, 177Andihka, Galih, 208Arkeman, Yandra, 43Baga, Lukman M, 69Cahyanugroho, Aldi, 112Daryanto, Arief, 12David, Ajibade, 139Djoni, 122Fahmi, Idqan, 1Fattah, Muhammad Unggul Abdul, 61Hakim, Dedi Budiman, 187Harianto, 93Hartoyo, 101Homisah, 1Hubeis, Musa, 112Hutagaol, M. Parulian, 93Jaya, Stevana

  8. Nutrient composition of five varieties of commonly consumed Nigerian groundnut (Arachis hypogaea L.

    Directory of Open Access Journals (Sweden)

    Tayo, G. O.

    2012-03-01

    .00-16.03mg/100g y tocoferoles (18.62-21.07mg/100g, siendo la variedad “Boro rojo” la que contiene las cantidades significativamente más altas (P P> Mg> Ca> Mn> Cu> Na> Zn> Fe> Al> Se. La variedad “Boro rojo” también tuvo el mayor contenido elemental en la mayoría de los minerales analizados. Por lo tanto, estos cacahuetes de la variedad “Boro rojo” es la más recomendable y pueden ser considerados unos productos alimenticios útiles para minimizar la malnutrición proteico-energética (MPE y las deficiencias de micronutrientes en Nigeria. El resultado de esta investigación puede suponer una significativa contribución a la tabla de composición de alimentos.

  9. New methods in order to determine the extent of temporary blinding from laser and LED light and proposal how to allocate into blinding groups

    Science.gov (United States)

    Reidenbach, Hans-Dieter; Ott, Günter; Brose, Martin; Dollinger, Klaus

    2010-02-01

    Indirect effects arising from bright artificial optical sources like temporary blinding might result in serious incidents or even accidents due to accompanying alteration of visual functions like visual acuity, contrast sensitivity and color discrimination. In order to determine the degree and duration of impairment resulting from glare, dazzle, flash-blindness and afterimages, caused by a beam from a laser or lamp product, particularly under low ambient light conditions, an investigation has been performed with the goal to improve the current knowledge as far as especially recovery duration of visual acuity is concerned. For this two different test set-ups were designed and engineered in order to be able to determine the time duration after which visual acuity returns to its previous value after temporary blinding with a laser or an LED and in addition to search for functional relations as far as wavelength, optical power and exposure duration are concerned. Instead of normal visual acuity measurement, which is the standard test done by eye care professionals, and which has been applied in order to determine the recovery time after irradiation with a high brightness LED (HB-LED) with the aid of a modified commercially available binoptometer with Landolt-C rings as optotypes, a special reading test on a computer monitor was developed for the case of laser irradiation. Two different laser were applied, one with a wavelength of 632.8 nm and the other with 532 nm. Red, green, royal blue and white HB-LEDs were used as stimulating light sources. The maximum applied optical power in a 7-mm aperture, which is equivalent to the pupil diameter of a dark adapted eye, was 0.783 mW (laser) and 3 mW (LED). The exposure durations were chosen as 0.25 s, 0.5 s, 1 s, 5 s, and 20 s in the case of laser irradiation and 0.25 s, 1 s, 5 s, and 10 s for LEDs, respecting maximum permissible exposure (MPE) and/or limit exposure levels (ELVs) in all exposure situations. The visual acuity

  10. Advances for laser ignition of internal combustion and rocket engines

    International Nuclear Information System (INIS)

    Schwarz, E.

    2011-01-01

    field laser physics. Unfortunately, there is no standard definition for the plasma threshold in the literature. Consequently, a clear definition of the focal volume is missing. For this reason it was tried to find a theoretical formula for the volume. This formula is based on the assumption that the focal volume encloses the space where the threshold intensity is higher than Ith =I0/2 or, alternatively, Ith = I0/e2. Laser energy transmission is one of the most important loss factors during plasma development by laser-induced optical breakdown and provides important information about the energy contained in the plasma. Hence, a number of plasma experiments were carried out. In our experiments is was found that for decreasing focal volume the plasma threshold energy (MPE) and the energy transmission can be reduced respectively. In order to investigate the possibility if laser-induced ignition can be made more efficient with respect to the laser pulse energy, several ignition experiments were performed. For these experiments a combustion chamber was employed at a filling pressure of 11 bar and a temperature of 110 o C involving different focal sizes. The thermal ignition experiments were carried out to demonstrate in principle the feasibility of thermal ignition via resonant absorption of IR radiation. By evaluating these results with respect to laser ignition of engines, it is conceivable to employ laser thermal ignition as an innovative ignition mechanism. As in HCCI (homogeneous charge compression ignition) engines and rocket engines, ignition occurs at specific elevated pressures and temperatures, it can be assumed that the ignition energies are in the range between 20 to 100 mJ. Furthermore, different laser ignition system concepts were developed and evaluated regarding to their qualification for rocket engine ignition. As a consequence of its highest rating in our study, resonant ignition should be considered an interesting alternative to laser spark ignition

  11. Coal fires in Indonesia

    Energy Technology Data Exchange (ETDEWEB)

    Whitehouse, Alfred E.; Mulyana, Asep A.S. [Office of Surface Mining/Ministry of Energy and Mineral Resources Coal Fire Project, Ministry of Energy and Mineral Resources, Agency for Training and Education, Jl. Gatot Subroto, Kav. 49, Jakarta 12950 (Indonesia)

    2004-07-12

    demonstrations to the Indonesian Government. Successful demonstrations obtained visible benefits for a large number of local interests and received overwhelmingly favorable public response. This built the public and political support needed to continue this work.These successes encouraged the Ministry to officially assume the responsibility for coal fire management by Decree 1539/20/MPE/1999. The Ministry reallocated internal funds to support portions of the immediate suppression projects and committed a portion of the Coal Royalty Fund to provide long-term support for coal fire suppression activities. Coal fires continue to present a serious risk to Indonesia's ecosystems, population and forest resources. The Ministry and local governments in East Kalimantan are still working on the coal fire inventory. It presently contains 164 coal fires, but it is far from complete. Unless these coal fires are managed or extinguished, they will add to the already catastrophic cycle of anthropogenic forest fires that further reduce Indonesia's forest resources and endangered species while contributing unnecessarily to global carbon emissions.

  12. ESA presents INTEGRAL, its space observatory for Gamma-ray astronomy

    Science.gov (United States)

    1998-09-01

    Baikonur is actually scheduled for 2001. ESA pioneered gamma-ray astronomy in space with its COS-B satellite (1975). Russia's Granat (1989) and NASA's Compton GRO (1991) followed. But INTEGRAL will be better still. With this mission ESA will further strengthen its lead in gamma-astronomy. Principal Investigators : Imager : Pietro Ubertini (IAS, Frascati, Italy) Spectrometer : Gilbert Vedrenne (CESR, Toulouse/France) Volker Schoenfelder (MPE, Garching/.Germany) X-Ray monitor : Niels Lund (DSRI, Copenhagen/Denmark) Optical Monitoring Camera : Alvaro Gimenez (INTA, Madrid/Spain) Integral Science Data Center : Thierry Courvoisier (Genova Observatory, Switzerland) For further information, please contact : ESA Public Relations Division Tel: +33(0)1.53.69.71.55 Fax: +33(0)1.53.69.76.90 INTEGRAL MEDIA DAY Tuesday 22 September 1998 Newton Conference Centre ESTEC, Noordwijk, Keplerlaan 1 (The Netherlands) Programme 10:30 . Arrival and Registration in the Newton Conference Centre 10:45. Welcome and introduction by David Dale, Director of ESTEC 10:50 The Scientific Challenge : the mission of INTEGRAL, by Chistoph Winkler, INTEGRAL Project Scientist 11:10 The Technical Challenge : the INTEGRAL spacecraft, by Kai Clausen, INTEGRAL Project Manager 11:30 The Industrial Challenge by A. Simeone, Programme Director at Aleniaspazio 11:45 Question/Answer session 12:00 Visit to INTEGRAL spacecraft ; photo and film opportunities, incl. Interview opportunities with speakers 13:00 Informal buffet lunch in Foyer of Conference Centre Newton 14:30 End of event

  13. X-rays Provide a New Way to Investigate Exploding Stars

    Science.gov (United States)

    2007-05-01

    exhausted. The duration of this X-ray emission traces the amount of material left on the white dwarf after the nova explosion. Optical Image of Andromeda Galaxy (M31) Optical Image of Andromeda Galaxy (M31) A well determined start time of the optical nova outburst and the X-ray turn-on and turn-off times are therefore important benchmarks for replication in computer models of novae. Whilst monitoring the M31 novae, frequently over several months, for the appearance and subsequent disappearance of the X-rays, Pietsch made an important discovery. Some novae start to emit X-rays and then turn them off again within just a few months. "These novae are a new class. They would have been overlooked before," says Pietsch. That's because previous surveys looked only every six months or so. Within that time, the fast X-ray novae could have blinked both on and off. In addition to discovering the short-lived ones, the new survey also confirms that other novae generate X-rays over a much longer time. XMM-Newton detected seven novae that were still shining X-rays into space, up to a decade after the original eruption. The differing lengths of times are thought to reflect the masses of the white dwarfs at the heart of the nova explosion. The fastest evolving novae are thought to be those coming from the most massive white dwarfs. To investigate further, the team have been awarded more XMM-Newton and Chandra observing time. They now plan to monitor M31's novae every ten days for several months, starting in November 2007 to glean more information about these puzzling stellar explosions. Notes for editors: X-ray monitoring of optical novae in M31 from July 2004 to February 2005 by W. Pietsch et al. is published in Astronomy and Astrophysics, 465, 375-392 (2007). For more information: Wolfgang Pietsch wnp@mpe.mpg.de Norbert Schartel Norbert.Schartel@sciops.esa.int

  14. Summary of Session 1 'Lessons from 2011'

    International Nuclear Information System (INIS)

    Lamont, M; Bracco, C

    2012-01-01

    288 bunches could be injected, during MD time, for both beams with a good margin between the losses and the BLM dump thresholds. Improvements are still needed to optimize the 25 ns beam in the injector chain and accumulate it in the LHC with a good lifetime; the results are encouraging in view of operation with the designed intensity. Machine Protection, M. Zerlauth (TE-MPE): M. Zerlauth introduced the architecture of the LHC Machine Protection System (MPS). He explained that this is a complex system that checks more than 10000 interlock conditions and has to evolve to follow operational changes, special runs and MD requirements. Vacuum Performance and Lessons for 2012, V. Baglin (TE-VSC): V. Baglin presented a talk on the main vacuum observations made in 2011: dynamic effects induced by the circulating beam (synchrotron radiation and e-clouds) and unexpected local pressure spikes. He explained that the desorption yield in the cold-warm transitions was much worse (factor 50) than in the warm-warm transition due to gas load from the cold part. Emittance Preservation, V. Kain (BE-OP): V. Kain spoke about emittance preservation all along the injectors chain up to collisions in the LHC. She explained that injectors behaved extremely well in 2011 and, for the 50 ns beams and a bunch population higher than nominal, an emittance blowup of 0.4 μm was measured from the PS to the SPS (from design report: 0.5 μm were estimated for 25 ns beams). On the other hand a 20-30% emittance growth is observed between the SPS flattop and LHC collisions. Several methods are used for emittance measurements (wire scanner, BSRT and luminosity) and all methods present some limitations. Moreover measurements in the SPS and in the LHC are not synchronized and refer to different beams.

  15. Black Holes Have Simple Feeding Habits

    Science.gov (United States)

    2008-06-01

    properties of these black holes should be very helpful. In addition to Chandra, three radio arrays (the Giant Meterwave Radio Telescope, the Very Large Array and the Very Long Baseline Array), two millimeter telescopes (the Plateau de Bure Interferometer and the Submillimeter Array), and Lick Observatory in the optical were used to monitor M81. These observations were made simultaneously to ensure that brightness variations because of changes in feeding rates did not confuse the results. Chandra is the only X-ray satellite able to isolate the faint X-rays of the black hole from the emission of the rest of the galaxy. This result confirms less detailed earlier work by Andrea Merloni from the Max Planck Institute for Extraterrestrial Physics (MPE) in Garching, Germany and colleagues that suggested that the basic properties of larger black holes are similar to the smaller ones. Their study, however, was not based on simultaneous, multi-wavelength observations nor the application of a detailed physical model. These results will appear in an upcoming issue of The Astrophysical Journal. NASA's Marshall Space Flight Center, Huntsville, Ala., manages the Chandra program for the agency's Science Mission Directorate. The Smithsonian Astrophysical Observatory controls science and flight operations from the Chandra X-ray Center in Cambridge, Mass.

  16. Summary of Session 1 'Lessons from 2011'

    Energy Technology Data Exchange (ETDEWEB)

    Lamont, M; Bracco, C [European Organization for Nuclear Research, Geneva (Switzerland)

    2012-07-01

    288 bunches could be injected, during MD time, for both beams with a good margin between the losses and the BLM dump thresholds. Improvements are still needed to optimize the 25 ns beam in the injector chain and accumulate it in the LHC with a good lifetime; the results are encouraging in view of operation with the designed intensity. Machine Protection, M. Zerlauth (TE-MPE): M. Zerlauth introduced the architecture of the LHC Machine Protection System (MPS). He explained that this is a complex system that checks more than 10000 interlock conditions and has to evolve to follow operational changes, special runs and MD requirements. Vacuum Performance and Lessons for 2012, V. Baglin (TE-VSC): V. Baglin presented a talk on the main vacuum observations made in 2011: dynamic effects induced by the circulating beam (synchrotron radiation and e-clouds) and unexpected local pressure spikes. He explained that the desorption yield in the cold-warm transitions was much worse (factor 50) than in the warm-warm transition due to gas load from the cold part. Emittance Preservation, V. Kain (BE-OP): V. Kain spoke about emittance preservation all along the injectors chain up to collisions in the LHC. She explained that injectors behaved extremely well in 2011 and, for the 50 ns beams and a bunch population higher than nominal, an emittance blowup of 0.4 μm was measured from the PS to the SPS (from design report: 0.5 μm were estimated for 25 ns beams). On the other hand a 20-30% emittance growth is observed between the SPS flattop and LHC collisions. Several methods are used for emittance measurements (wire scanner, BSRT and luminosity) and all methods present some limitations. Moreover measurements in the SPS and in the LHC are not synchronized and refer to different beams.

  17. SINFONI Opens with Upbeat Chords

    Science.gov (United States)

    2004-08-01

    Dutch Institutes and ESO who have worked on the development of SINFONI for nearly 7 years. The work on SINFONI at Paranal included successful commissioning in June 2004 of the Adaptive Optics Module built by ESO, during which exceptional test images were obtained of the main-belt asteroid (22) Kalliope and its moon. Moreover, the ability was demonstrated to correct the atmospheric turbulence by means of even very faint "guide" objects (magnitude 17.5), crucial for the observation of astronomical objects in many parts of the sky. SPIFFI - SPectrometer for Infrared Faint Field Imaging - was developed at the Max Planck Institute for Extraterrestrische Physik (MPE) in Garching (Germany), in a collaboration with the Nederlandse Onderzoekschool Voor Astronomie (NOVA) in Leiden and the Netherlands Foundation for Research in Astronomy (ASTRON), and ESO. PR Photo 24a/04: SINFONI Adaptive Optics Module at VLT Yepun (June 2004) PR Photo 24b/04: SINFONI at VLT Yepun, now fully assembled (July 2004) PR Photo 24c/04: "First Light" image from the SINFONI Adaptive Optics Module PR Photo 24d/04: AO-corrected Image of a 17.5-magnitude Star PR Photo 24e/04: SINFONI undergoing Balancing and Flexure Tests at VLT Yepun PR Photo 24f/04: SINFONI "First Light" Spectrum of HD 130163 PR Photo 24g/04: Members of the SINFONI Adaptive Optics Module Commissioning Team PR Photo 24h/04: Members of the SPIFFI Commissioning Team PR Photo 24i/04: The Principle of Integral Field Spectroscopy (IFS) PR Photo 24j/04: The Orbital Motion of Linus around (22) Kalliope PR Photo 24k/04: SINFONI Observations of the Galactic Centre Region PR Photo 24l/04: SINFONI Observations of the Circinus Galaxy PR Photo 24m/04: SINFONI Observations of the AGN Galaxy NGC 7469 PR Photo 24n/04: SINFONI Observations of NGC 6240 PR Photo 24o/04: SINFONI Observations of the Young Starforming Galaxies BX 404/405 PR Video Clip 07/04: The Orbital Motion of Linus around (22) Kalliope SINFONI: A powerful and complex instrument ESO PR Photo

  18. The GalileoMobile starts its South American voyage - Astronomy education goes on tour through the Andes Mountains

    Science.gov (United States)

    2009-10-01

    forward to helping the team members make the GalileoMobile a great success." To chronicle this remarkable astronomy expedition, members of the GalileoMobile team will write entries for the GalileoMobile blog and Cosmic Diary, an online blog-cum-journal that is also a Cornerstone IYA2009 project, and run a Twitter feed and a Facebook page. The team will reach out to national newspapers, websites and television stations during the tour, and will be accompanied by a film crew who will produce a multilingual documentary of the expedition. Project Coordinator Philippe Kobel concludes: "We hope that, by showing the excitement of astronomical discovery, and the diversity and richness of the South American traditions, the GalileoMobile Project will encourage a feeling of 'unity under the same sky' between people of different cultures and backgrounds." The GalileoMobile is supported by the European Southern Observatory (ESO), whose host country is Chile and which is the seat of the International Year of Astronomy 2009 (IYA2009) Secretariat, the Max Planck Society (MPG/MPE/MPA/MPS), NORDITA, Regione Molise and the Optical Society of America. Notes [1] To facilitate access to remote sites and foster the communication and translation in native non-Spanish languages, such as Quechua and Aymara, local university students or education officials will join the GalileoMobile team from time to time. More information ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 14 countries: Austria, Belgium, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role

  19. Sharpest Ever VLT Images at NAOS-CONICA "First Light"

    Science.gov (United States)

    2001-12-01

    demonstration of the value of international collaboration. ESO and its partner institutes and companies in France and Germany have worked a long time towards this goal - with the first, extremely promising results, we shall soon be able to offer a new and fully tuned instrument to our wide research community." The NAOS adaptive optics corrector was built, under an ESO contract, by Office National d'Etudes et de Recherches Aérospatiales (ONERA) , Laboratoire d'Astrophysique de Grenoble (LAOG) and the DESPA and DASGAL laboratories of the Observatoire de Paris in France, in collaboration with ESO. The CONICA infra-red camera was built, under an ESO contract, by the Max-Planck-Institut für Astronomie (MPIA) (Heidelberg) and the Max-Planck Institut für Extraterrestrische Physik (MPE) (Garching) in Germany, in collaboration with ESO. The present event happens less than four weeks after "First Fringes" were achieved for the VLT Interferometer (VLTI) with two of the 8.2-m Unit Telescopes. No wonder that a spirit of great enthusiasm reigns at Paranal! Information for the media: ESO is producing a Video News Release ( ESO Video News Reel No. 13 ) with sequences from the NAOS-CONICA "First Light" event at Paranal, a computer animation illustrating the principle of adaptive optics in NAOS-CONICA, as well as the first astronomical images obtained. In addition to the usual distribution, this VNR will also be transmitted via satellite Friday 7 December 2001 from 09:00 to 09:15 CET (10:00 to 10:15 UT) on "Europe by Satellite" . These video images may be used free of charge by broadcasters. Satellite details, the script and the shotlist will be on-line from 6 December on the ESA TV Service Website http://television.esa.int. Also a pre-view Real Video Stream of the video news release will be available as of that date from this URL. Video Clip 07/01 : Various video scenes related to the NAOS-CONICA "First Light" Event ( ESO Video News Reel No. 13 ). PR Photo 33a/01 : NAOS-CONICA "First light

  20. A systematic search for new X-ray pulsators in ROSAT fields

    Science.gov (United States)

    Israel, G. L.

    1996-10-01

    powered neutron stars, some of which were observed in the X-ray band, can show highly coherent signals as well. Photospheric oscillations due to opacity instability in a layer close to the surface of an isolated hot white dwarf or pre-white dwarf star can be also observed in the very soft X-ray band. Light curves with increased statistical quality, time resolution and duration have become available in recent years for a variety of astronomical objects and over different bands of the electromagnetic spectrum. Power spectrum analysis is probably the single most important technique that is applied to time series, in order to detect periodicities and quasi-periodicities by the presence of significant power spectrum peaks. Applications to time series of high energy astronomical data have been especially numerous and successful over the last decade, as a consequence of the pronounced variability (often both periodic and non-periodic in character) detected in many sources. ROSAT, an acronym for the German word Rontgensatellit, is an X-ray satellite launched in June 1990. Its X-ray telescope covers the soft X-ray band from 0.05 keV to 2.4 keV. The main aim of the mission was to perform the first all-sky survey (RASS) with imaging telescopes, possessing an X-ray sensitivity of about a factor 1000 higher than that of UHURU. The survey took the first 6 months of the operations of ROSAT. After that the satellite has been used to carry out pointed observations of selected targets. These observations cover a much smaller portion of the sky than the RASS, but afford a factor 10-1000 higher sensitivity. A systematic exploitation of the public domain ROSAT pointed observations with the Position Sensitive Proportional Counter (PSPC; about 10% of the sky and about 5300 fields until May 1996) was carried out by several groups. NASA-HEASARC and MPE have produced catalogues containing about 60000 serendipitous sources (WGA by White, Giommi & Angelini 1994; ROSATSRC by Zimmermann 1994). This

  1. Youngest Brown Dwarf Yet in a Multiple Stellar System

    Science.gov (United States)

    2000-07-01

    that direct detection and subsequent, effective spectroscopic verification of extra-solar planets is now quite feasible with a ground-based facility like the VLT. It is thus not a very daring prediction that the ongoing searches may soon lead to the first direct images of an extra-solar planet. These are indeed exciting times! More information The work described in this Press Release is discussed by the team in a research article that has been accepted for publication in the European journal Astronomy & Astrophysics. Another paper ( "Direct imaging search for planetary companions next to young nearby stars" ) is also available with more details about the current searches, including the spectrum of the background star at TWA-7. The Principal Investigator for this project may be contacted at: Ralph Neuhaeuser Max-Planck-Institut für Extraterrestrische Physik D-85748 Garching Germany Phone +49-89-32993398 email: rne@mpe.mpg.de Notes [1]: The team consists of Ralph Neuhaeuser (Principal Investigator) and Nuria Huelamo (both Max-Planck-Institut für Extraterrestrische Physik, Garching, Germany), Eike Guenther (Landessternwarte Tautenburg, Germany), Monika Petr (Max-Planck-Institut für Radioastronomie, Bonn, Germany), Wolfgang Brandner (Institute for Astronomy, Honolulu, Hawaii, USA) and João Alves (ESO, Garching, Germany). [2]: The hitherto sharpest image (0.25 arcsec) was obtained in March 1999, cf. ESO PR 06/99. It was obtained during a period of exceptionally good "seeing" (low level of atmospheric turbulence). The installation of adaptive optics at the VLT, foreseen in 2001, will provide a means to overcome the image smearing effect of air turbulence and hence, consistently obtain stellar images of a few hundredths of an arcsecond diameter, near the theoretical limit for an 8.2-m telescope (the telescope diffraction limit ). [3]: 1 solar mass = 2 x 10 30 kg. 1 Jupiter mass = 2 x 10 27 kg ~ 0.001 solar mass. Thus, the "BD-limit" of 0.08 solar masses corresponds to