WorldWideScience

Sample records for monograph series effective

  1. When Teachers Lead. UCEA Monograph Series.

    Science.gov (United States)

    Astuto, Terry A., Ed.

    This document contains six chapters that examine the role of teacher leadership in the school-restructuring process. Chapter 1, "When--Teachers Lead" (Bruce S. Cooper), provides a general introduction to the content and purpose of the monograph. Chapter 2, "When--Teachers Share School-Level Decision-Making" (Sharon Conley and Justo Robles),…

  2. State Defense Force Monograph Series. Winter 2006, Medical Support Teams

    Science.gov (United States)

    2006-01-01

    assets for mobile support teams, labs, immunizations, latent TB screening, and post-deployment assessments.” (COL Eric Allely, Maryland State Surgeon...infarctions ! Diabetes ! Mental health problems ! Hypertension ! Diarrhea ! Heat injuries 30 State Defense Force Monograph Series, Summer 2006...for dysentery and vomiting ! Viral meningitis ! Injuries due to off-site fighting ! Tuberculosis ! HIV ! Special medical needs. See Figures 3

  3. Regulation and Education: Strategies for Solving the Bottle Feeding Problem. Monograph Series No. 4.

    Science.gov (United States)

    Greiner, Ted

    This book is the fourth monograph in the Cornell International Monograph Series, the second in the series to deal with the question of breast versus bottle feeding. The introduction to the monograph discusses the shift from breast to bottle feeding in both industrialized and developing nations. Some of the reasons for, and consequences of, the…

  4. The Chemistry of Food Dyes. Palette of Color Monograph Series.

    Science.gov (United States)

    Epp, Dianne N.

    Dyes aren't just for fabrics--colorants have been added to food for centuries to enhance its appearance. This monograph and teaching guide investigates both the compounds that give foods their natural color and synthetic colorants currently approved for use in foods. Problem-solving inquiry based activities involve high school level students in…

  5. The Chemistry of Food Dyes. Palette of Color Monograph Series.

    Science.gov (United States)

    Epp, Dianne N.

    Dyes aren't just for fabrics--colorants have been added to food for centuries to enhance its appearance. This monograph and teaching guide investigates both the compounds that give foods their natural color and synthetic colorants currently approved for use in foods. Problem-solving inquiry based activities involve high school level students in…

  6. Safety in Team Sports. Sports Safety Series, Monograph No. 3.

    Science.gov (United States)

    Borozne, Joseph, Ed.; And Others

    This monograph examines methods of promoting safe practices in the conduct of selected team sports with the aim of reducing and eliminating the occurrance of injuries. The team sports discussed are baseball and softball, basketball, field hockey, tackle football, touch and flag football, ice hockey, lacrosse, and soccer. (MJB)

  7. Assessing Creativity: A Guide for Educators. Research Monograph Series.

    Science.gov (United States)

    Treffinger, Donald J.; Young, Grover C.; Selby, Edwin C.; Shepardson, Cindy

    This monograph deals specifically with the challenge of recognizing or assessing creativity. Following an introductory chapter, chapter 2 focuses on definitions and characteristics of creativity to help clarify the nature and meaning of creativity and creative thinking, and to consider the implications of those definitions for assessment. The…

  8. 76 FR 51034 - Availability of Draft NTP Monograph on Potential Developmental Effects of Cancer Chemotherapy...

    Science.gov (United States)

    2011-08-17

    ... HUMAN SERVICES Availability of Draft NTP Monograph on Potential Developmental Effects of Cancer... Monograph AGENCY: Division of the National Toxicology Program (DNTP), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health. ACTION: Availability of Draft Monograph; Request...

  9. Logo and Geometry. Journal for Research in Mathematics Education Monograph Series.

    Science.gov (United States)

    Clements, Douglas H.; Battista, Michael T.

    This book, the 10th volume in the Journal for Research in Mathematics Education (JRME) Monograph Series, discusses the geometry curriculum and investigates how elementary school students learn geometric concepts and how Logo programming and its turtle graphics might affect this learning. This volume also provides details on the development,…

  10. The Evaluation and Selection of Instructional Software for Use with the Learning Disabled. CREATE Monograph Series.

    Science.gov (United States)

    Weisgerber, Robert A.; Blake, Patricia L.

    Fourth in a series of six monographs on the use of new technologies in the instruction of learning disabled (LD) students, this paper explores issues related to the evaluation and selection of instructional software for LD students. Topics discussed include the following: (1) criteria for instructionally useful software (e.g., flexibility and…

  11. The Learning Disabled and Computer Based Education: Program Design Strategies. CREATE Monograph Series.

    Science.gov (United States)

    Rubin, David; And Others

    Third in a series of six monographs on the use of new technologies in the instruction of learning disabled students, the paper explores program design strategies for computer-based instructional materials. Section 1 summarizes ideas related to models of perception and cognition, theories of instruction, and key characteristics of intelligent…

  12. Existing and Emerging Technologies in Education: A Descriptive Overview. CREATE Monograph Series.

    Science.gov (United States)

    Bakke, Thomas W.

    Second in a series of six monographs on the use of new technologies in the instruction of learning disabled students, the paper offers a descriptive overview of new technologies. Topics addressed include the following: (1) techniques for sharing computer resources (including aspects of networking, sharing information through databases, and the use…

  13. Optimal Approaches to Microcomputer Implementation in the Schools. [CREATS Monograph Series.

    Science.gov (United States)

    Bakke, Thomas W.

    Fifth in a series of six monographs on the use of new technologies in the instruction of learning disabled students, the paper describes how schools can plan for the acquisition of computer hardware and software, and how they can provide district-level staff training in its use. Discussion focuses on the development of a technology implementation…

  14. Acacia mangium: Growing and utilization. MPTS monograph series No. 3

    Energy Technology Data Exchange (ETDEWEB)

    Awang, K.; Taylor, D.

    1993-01-01

    With deforestation in the Asia-Pacific region progressing at the rate of 4.4 million ha per year, many countries have adopted plantation forestry using fast-growing species as a way to sustain the commercial supply of tree products and reduce pressure on natural forests. Acacia mangium (A. mangium) is playing a large role in this development, especially in Indonesia and Malaysia, due to its versatility and its ability to recapture grasslands dominated by the noxious weed, Imperata cylindrica. This monograph consolidates information on A. mangium from published literature, unpublished reports and studies, and observations from those familiar with the species. Priorities for future research are included in each chapter and in the final summary.

  15. The UNO Aviation Monograph Series: The Airline Quality Rating 1998

    Science.gov (United States)

    Bowen, Brent D.; Headley, Dean E.

    1998-01-01

    The Airline Quality Rating (AQR) was developed and first announced in early 1991 as an objective method of comparing airline performance on combined multiple factors important to consumers. Development history and calculation details for the AQR rating system are detailed in The Airline Quality Rating 1991 issued in April, 1991, by the National Institute for Aviation Research at Wichita State University. This current report, Airline Quality Rating 1998, contains monthly Airline Quality Rating scores for 1997. Additional copies are available by contacting Wichita State University or University of Nebraska at Omaha. The Airline Quality Rating 1998 is a summary of month-by-month quality ratings for the ten major U.S. airlines operating during 1997. Using the Airline Quality Rating system and monthly performance data for each airline for the calendar year of 1997, individual and comparative ratings are reported. This research monograph contains a brief summary of the AQR methodology, detailed data and charts that track comparative quality for major airlines domestic operations for the 12 month period of 1997, and industry average results. Also, comparative Airline Quality Rating data for 1991 through 1996 are included to provide a longer term view of quality in the industry.

  16. The UNO Aviation Monograph Series: The Airline Quality Rating 1997

    Science.gov (United States)

    Bowen, Brent D.; Headley, Dean E.

    1997-01-01

    The Airline Quality Rating (AQR) was developed and first announced in early 1991 as an objective method of comparing airline performance on combined multiple factors important to consumers. Development history and calculation details for the AQR rating system are detailed in The Airline Quality Rating 1991 issued in April, 1991, by the National Institute for Aviation Research at Wichita State University. This current report, Airline Rating 1997, contains monthly Airline Quality Rating scores for 1996. Additional copies are available by contacting Wichita State University or the University of Nebraska at Omaha. The Airline Quality Rating (AQR) 1997 is a summary of a month-by-month quality ratings for the nine major domestic U.S. airlines operating during 1996. Using the Airline Quality Rating system and monthly performance data for each airline for the calendar year of 1996, individual and comparative ratings are reported. This research monograph contains a brief summary of the AQR methodology, detailed data and charts that track comparative quality for major domestic airlines across the 12 month period of 1996, and industry average results. Also comparative Airline Quality Rating data for 1991 through 1995 are included to provide a longer term view of quality in the industry.

  17. 77 FR 48995 - Draft National Toxicology Program (NTP) Monograph on Developmental Effects and Pregnancy Outcomes...

    Science.gov (United States)

    2012-08-15

    ... HUMAN SERVICES National Institutes of Health Draft National Toxicology Program (NTP) Monograph on... of the draft monograph. Topic: Peer review of the draft NTP Monograph on Developmental Effects and... scheduled for oral public comment. The NTP also invites written comments on the draft monograph, submission...

  18. Truth, Perception, and Consequences (Proteus Monograph Series, Volume 1, Issue 1, November 2007)

    Science.gov (United States)

    2007-11-01

    TruTh , PercePTion, and consequences The Proteus Monograph Series Volume 1, Issue 1 November 2007 Report Documentation Page Form ApprovedOMB No. 0704...2007 to 00-00-2007 4. TITLE AND SUBTITLE Truth , Perception, and Consequences 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...Intelligence, or the U.S. Government. This report is cleared for public release; distribution is unlimited. TruTh , PercePTion, and consequences by

  19. NTP monograph on health effects of low-level lead.

    Science.gov (United States)

    2012-06-01

    Although reductions in lead (Pb) exposure for the U.S. population have resulted in lower blood Pb levels over time, epidemiological studies continue to provide evidence of health effects at lower and lower blood Pb levels. Low-level Pb was selected for evaluation by the National Toxicology Program (NTP) because of (1) the availability of a large number of epidemiological studies of Pb, (2) a nomination by the National Institute for Occupational Safety and Health for an assessment of Pb at lower levels of exposure, and (3) public concern for effects of Pb in children and adults. This evaluation summarizes the evidence in humans and presents conclusions on health effects in children and adults associated with low-level Pb exposure as indicated by less than 10 micrograms of Pb per deciliter of blood (Monograph on Health Effects of Low-Level Lead. The document and appendices are available at http://ntp.niehs.nih.gov/go/evals. This document provides background on Pb exposure and includes a review of the primary epidemiological literature for evidence that low-level Pb is associated with neurological, immunological, cardiovascular, renal, and/or reproductive and developmental effects. The NTP Monograph presents specific conclusions for each health effect area. Overall, the NTP concludes that there is sufficient evidence that blood Pb levels Monograph on November 17-18, 2011 (http://ntp.niehs.nih.gov/go/37090.

  20. Screening assays for carcinogenic agents and mixtures: an appraisal based on data in the IARC Monograph series.

    Science.gov (United States)

    Bartsch, H; Malaveille, C

    1990-01-01

    To determine whether genotoxic and non-genotoxic carcinogens contribute similarly to the cancer burden in humans and which types of short-term test are more relevant for predicting human hazards, an analysis was performed on agents that were evaluated in IARC Monographs Supplements 6 and 7 for their carcinogenic effects in humans and animals and for activity in short-term genotoxicity tests. The prevalence of genotoxicity among four groups of agents, consisting of established human carcinogens (group 1, n = 30), probable human carcinogens (group 2A, n = 37), possible human carcinogens (group 2B, n = 113) and agents with limited evidence of carcinogenicity in animals (a subset of group 3, n = 66) was determined. Each of the groups 1, 2A and 2B contained a high proportion (80-90%) of genotoxic carcinogens, which were also multi-species or multi-tissue carcinogens. The distribution of carcinogenic potency in rodents did not reveal any specific characteristic of the human carcinogens in group 1 that would differentiate them from agents in groups 2A, 2B and many in group 3. Although limited by the data-base available through the Monographs series, this analysis implies that genotoxic carcinogens add more to the human cancer burden than non-genotoxic carcinogens. Thus, the continued use of in vitro/in vivo short-term tests, involving as endpoints DNA chromosomal or mutational damage, to identify genotoxic carcinogens or in the isolation of carcinogenic components in complex mixtures is fully justified. It is concluded that (a) an agent or complex mixture with unknown carcinogenic potential showing sufficient evidence of activity in genotoxicity assays in vitro or in vivo is likely to represent a hazard to humans and (b) an agent or complex mixture showing lack of activity in this spectrum of genotoxicity assays should undergo evaluation for carcinogenicity for rodent bioassay, in view of the present lack of validated short-term tests for non-genotoxic carcinogens.

  1. Administration of Literacy Programmes. Planning, Administration and Monitoring in Literacy; Portfolio of Literacy Materials, Series 2, Monograph 2.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and the Pacific.

    The second of three related monographs resulting from a Unesco regional literacy workshop in Asia, this booklet provides information useful to those administering national programs in literacy training in underdeveloped and developing nations. The introduction discusses the reasons why an effective administration machinery for literacy and adult…

  2. 76 FR 61704 - Availability of Draft NTP Monograph on the Health Effects of Low-Level Lead; Request for Comments...

    Science.gov (United States)

    2011-10-05

    ... HUMAN SERVICES Availability of Draft NTP Monograph on the Health Effects of Low- Level Lead; Request for Comments; Announcement of a Panel Meeting to Peer Review Draft Monograph AGENCY: Division of the National... of Health. ACTION: Availability of Draft NTP Monograph; Request for Comments; Announcement of a Peer...

  3. 76 FR 55391 - Notice of Postponement of Release of Draft NTP Monograph on Potential Developmental Effects of...

    Science.gov (United States)

    2011-09-07

    ... HUMAN SERVICES Notice of Postponement of Release of Draft NTP Monograph on Potential Developmental Effects of Cancer Chemotherapy During Pregnancy and Panel Meeting To Peer Review Draft Monograph AGENCY... (NIEHS), National Institutes of Health. ACTION: Notice of postponement of draft NTP monograph and peer...

  4. Nutritional Problems and Policy in Tanzania. Cornell International Nutrition Monograph Series, Number 7 (1980).

    Science.gov (United States)

    Mgaza, Olyvia

    This monograph discusses policies designed to deal with food and nutrition problems in Tanzania. Available information on food supplies and nutritional conditions in Tanzania clearly shows that the country faces nutritional problems; protein energy malnutrition is the most serious and requires priority action. Iron deficiency anemia, goiter, and…

  5. Administration and Supervision for Safety in Sports. Sports Safety Series: Monograph No. 1.

    Science.gov (United States)

    Borozne, Joseph, Ed.; And Others

    Examined in this monograph are issues concerned with accident problems in sports. Materials are organized under eight headings, each developed by an expert in the area: (1) the injury problem in sports; (2) philosophy of sports accident prevention and injury control; (3) an introduction to administration and supervision; (4) administration and…

  6. Honors Programs at Smaller Colleges. 3rd Edition. National Collegiate Honors Council Monograph Series

    Science.gov (United States)

    Schuman, Samuel

    2011-01-01

    This monograph focuses upon areas of special concern to those working with honors at smaller colleges and universities: mission, recruitment, facilities, administration, budget, and curriculum. In each area, the author makes some general suggestions about overall operating principles, note specific issues that can lead to difficulties, and suggest…

  7. Employer Relations and Recruitment Services: An Essential Part of Postsecondary Career Services. Monograph Series

    Science.gov (United States)

    Hoover, Myrna P.; Lenz, Janet G.; Garis, Jeff

    2013-01-01

    This monograph is intended for any career services provider seeking a guide for developing employer relations and recruitment services at a postsecondary institution. It serves to inform readers about the changing meaning of "placement" over the years and the role it currently plays in career services. The publication describes…

  8. Place as Text: Approaches to Active Learning. 2nd Edition. National Collegiate Honors Council Monograph Series

    Science.gov (United States)

    Braid, Bernice, Ed.; Long, Ada, Ed.

    2010-01-01

    The decade since publication of "Place as Text: Approaches to Active Learning" has seen an explosion of interest and productivity in the field of experiential education. This monograph presents a story of an experiment and a blueprint of sorts for anyone interested in enriching an existing program or willing to experiment with pedagogy…

  9. Recent Advances in Nutrition Education. The Health Education Monograph Series. Volume 15 Number 3.

    Science.gov (United States)

    Shier, Nathan W., Ed.; Torabi, Mohammad R., Ed.

    This monograph presents a collection of articles on nutrition education: "Using the DINE Score To Improve Food Choice Behavior" (Darwin Dennison and Kathryn F. Dennison); "Self-Reported Food Intake Patterns of Older Adults in Australia, China, and the United States" (Alyce D. Fly, Nathan W Shier, Barbara A. Hawkins, Susan J.…

  10. Employer Relations and Recruitment Services: An Essential Part of Postsecondary Career Services. Monograph Series

    Science.gov (United States)

    Hoover, Myrna P.; Lenz, Janet G.; Garis, Jeff

    2013-01-01

    This monograph is intended for any career services provider seeking a guide for developing employer relations and recruitment services at a postsecondary institution. It serves to inform readers about the changing meaning of "placement" over the years and the role it currently plays in career services. The publication describes…

  11. The Aeronautics Education, Research, and Industry Alliance (AERIAL) 2002 Report. UNO Aviation Monograph Series. UNOAI Report.

    Science.gov (United States)

    Bowen, Brent D.; Box, Richard C.; Fink, Mary M.; Gogos, George; Lehrer, Henry R.; Narayanan, Ram M.; Nickerson, Jocelyn S.; O'Neil, Patrick D.; Tarry, Scott E.; Vlasek, Karisa D.

    This document contains four papers on aeronautics education, research, and partnerships that partly supported through the Aeronautics Education, Research, and Industry Alliance (AERIAL). The paper "2002 AERIAL Monograph" (Brent D. Bowen, Jocelyn S. Nickerson, Mary M. Fink, et al.) presents an overview of research and development in the…

  12. Prevalence of genotoxic chemicals among animal and human carcinogens evaluated in the IARC Monograph Series.

    Science.gov (United States)

    Bartsch, H; Malaveille, C

    1989-06-01

    To determine whether genotoxic and non-genotoxic carcinogens contribute similarly to the cancer burden in humans, an analysis was performed on agents that were evaluated in Supplements 6 and 7 to the IARC Monographs for their carcinogenic effects in humans and animals and for the activity in short-term genotoxicity tests. The prevalence of genotoxic carcinogens on four groups of agents, consisting of established human carcinogens (group 1, n = 30), probable human carcinogens (group 2A, n = 37), possible human carcinogens (group 2B, n = 113) and on agents with limited evidence of carcinogenicity in animals (a subset of group 3, n = 149) was determined. A high prevalence in the order of 80 to 90% of genotoxic carcinogens was found in each of the groups 1, 2A and 2B, which were also shown to be multi-species/multi-tissues carcinogens. The distribution of carcinogenic potency in rodents did not reveal any specific characteristic of the human carcinogens in group 1 that would differentiate them from agents in groups 2A, 2B and 3. The results of this analysis indicate that (a) an agent with unknown carcinogenic potential showing sufficient evidence of activity in in vitro/in vivo genotoxicity assays (involving as endpoints DNA damage and chromosomal/mutational damage) may represent a hazard to humans; and b) an agent showing lack of activity in this spectrum of genotoxicity assays should undergo evaluation for carcinogenicity by rodent bioassay, in view of the present lack of validated short-term tests for non-genotoxic carcinogens. Overall, this analysis implies that genotoxic carcinogens add more to the cancer burden in man than non-genotoxic carcinogens. Thus, identification of such genotoxic carcinogens and subsequent lowering of exposure will remain the main goal for primary cancer prevention in man.

  13. The UNO Aviation Monograph Series: Aviation Security: An Annotated Bibliography of Responses to the Gore Commission

    Science.gov (United States)

    Carrico, John S.; Schaaf, Michaela M.

    1998-01-01

    This monograph is a companion to UNOAI Monograph 96-2, "The Image of Airport Security: An Annotated Bibliography," compiled in June 1996. The White House Commission on Aviation Safety and Security, headed by Vice President Al Gore, was formed as a result of the TWA Flight 800 crash in August 1996. The Commission's final report included 31 recommendations addressed toward aviation security. The recommendations were cause for security issues to be revisited in the media and by the aviation industry. These developments necessitated the need for an updated bibliography to review the resulting literature. Many of the articles were written in response to the recommendations made by the Gore Commission. "Aviation Security: An Annotated Bibliography of Responses to the Gore Commission" is the result of this need.

  14. Corrections and Juvenile Justice: Current Education Practice for Youth with Learning and Other Disabilities. Monograph Series on Education, Disability and Juvenile Justice.

    Science.gov (United States)

    Howell, Kenneth W.; Wolford, Bruce I.

    This monograph, one of a series on youth with disabilities and the juvenile justice system, focuses on the educational services provided to youth with behavioral and cognitive disabilities placed in the juvenile justice system. It reports on a review of correctional system monitoring reports, materials from enforcement actions taken against…

  15. Organizing for Student Success: The University College Model. The First Year Experience Monograph Series No. 53

    Science.gov (United States)

    Evenbeck, Scott E.; Jackson, Barbara; Smith, Maggy; Ward, Dorothy

    2010-01-01

    Organizing for Student Success draws on data from more than 50 institutions to provide insight into how university colleges are organized, the initiatives they house, and the practices in place to ensure their effectiveness. Twenty case studies from 15 different campuses offer an in-depth understanding of institutional practice. Ultimately,…

  16. Planning of Literacy Programmes. Planning, Administration and Monitoring in Literacy; Portfolio of Literacy Materials, Series 2, Monograph 1.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and the Pacific.

    The first of three related monographs resulting from a Unesco regional literacy workshop in Asia, this booklet provides information useful to those designing national programs in literacy training for underdeveloped and developing nations. Following an introduction, the booklet discusses the formulation of both policy guidelines and policy…

  17. Monitoring of Literacy Programmes. Planning, Administration and Monitoring in Literacy; Portfolio of Literacy Materials, Series 2, Monograph 3.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and the Pacific.

    The third of three related monographs resulting from a Unesco regional literacy workshop in Asia, this booklet provides information useful to those designing national programs in literacy training for underdeveloped and developing nations. The booklet is divided into four parts. The first part discusses the monitoring of literacy programs,…

  18. Monographs and Open Access

    Directory of Open Access Journals (Sweden)

    Geoffrey Crossick

    2016-03-01

    Full Text Available This article presents the project that I led for HEFCE on the implications of OA (open access for monographs and other long-form research publications. The likely requirement that books should be OA if submitted to the REF (Research Excellence Framework after next means that OA development must be based on an understanding of the importance of the monograph in the AHSS (arts, humanities and social sciences as well as the challenges involved in making the transition to online OA. The project focused on three issues and each is summarized in turn in the article: What is the place of the monograph and other long-form publications in AHSS disciplines that makes it so important? What is happening to the monograph and is there a crisis as some suggest? What are the issues involved in moving monographs into a digital and OA environment – not just the challenge of effective business models but also many other aspects of sustaining and enhancing the qualities of the monograph? These include third-party rights, technical challenges, licences and the need for international collaboration.

  19. NTP Monograph: Developmental Effects and Pregnancy Outcomes Associated With Cancer Chemotherapy Use During Pregnancy.

    Science.gov (United States)

    2013-05-01

    The National Toxicology Program (NTP) Office of Health Assessment and Translation (OHAT) conducted an evaluation of the developmental effects and pregnancy outcomes associated with cancer chemotherapy use during pregnancy in humans. The final NTP monograph was completed in May 2013 (available at http:// ntp.niehs.nih.gov/go/36495). The incidence of cancer during pregnancy has been reported to occur from 17 to 100 per 100,000 pregnant women. Chemotherapy is a common treatment for cancer; however, most chemotherapy agents are classified as known or suspected human teratogens. Cancer chemotherapy use during pregnancy was selected for evaluation by the NTP because of the: (1) paucity of comprehensive reviews on the pregnancy outcomes following cancer chemotherapy use during pregnancy in humans, including the integration of the developmental animal toxicology literature with the observational studies in humans, and (2) growing public interest in the developmental effects of chemotherapy on offspring exposed to cancer chemotherapy during gestation due to the expected incidence of cancer diagnosed during pregnancy as women delay pregnancy to later ages. Of the approximately 110 cancer chemotherapeutic agents currently in use, the NTP monograph includes data on 56 agents used during 1,261 pregnancies for which pregnancy outcomes were documented. Overall, the NTP evaluation found that treatment with chemotherapy for cancer appeared to be associated with: (1) a higher rate of major malformations following exposure during the first trimester compared to exposure in the second and/or third trimester; (2) an increase the rate of stillbirth following exposure in the second and/ or third trimester; abnormally low levels of amniotic fluid (primarily attributable to Trastuzumab); and (3), also data are insufficient, impaired fetal growth and myelosuppression. Treatment with chemotherapy for cancer during pregnancy did not appear to increase spontaneous preterm birth, or impair

  20. The Law of Procedure in Student Suspensions and Expulsions. NOLPE Monograph Series. ERIC/CEM State-of-the-Knowledge Series, Number Thirty-four.

    Science.gov (United States)

    Phay, Robert E.

    This state-of-the-knowledge paper, a companion to the author's 1975 monograph on a similar topic, examines the legal ramifications of student suspension, expulsion, and search and seizure of students' property. The author reviews relevant court litigation and state laws pertaining to specific rules on student conduct, the procedures to follow in…

  1. School Administrators and the Courts: A Review of Recent Decisions. ERS Monograph. Series, No. 3. ERIC/CEM State-of-the-Knowledge Series, No. 30.

    Science.gov (United States)

    Hudgins, H. C., Jr.

    This monograph is a review of selected judicial decisions reported by state and federal courts during the past two years and related directly to the administration of elementary or secondary schools. The decisions were identified through a standard search of legal resources at the Temple University Law Library; each decision was read in its…

  2. IARC Monographs

    DEFF Research Database (Denmark)

    Pearce, Neil E; Blair, Aaron; Vineis, Paolo

    2015-01-01

    BACKGROUND: Recently the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also the approach used to perform these evaluations. Some critics have claimed that IARC Working Groups...... carcinogens. We have examined here criticisms of the IARC classification process to determine the validity of these concerns. We review the history of IARC evaluations and describe how the IARC evaluations are performed. DISCUSSION: We conclude that these recent criticisms are unconvincing. The procedures....... This does not mean, however, that the current procedures are flawed. CONCLUSIONS: The IARC Monographs have made, and continue to make, major contributions to the scientific underpinning for societal actions to improve the public's health....

  3. NTP-CERHR monograph on the potential human reproductive and developmental effects of bisphenol A.

    Science.gov (United States)

    Shelby, Michael D

    2008-09-01

    The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an evaluation of the potential for bisphenol A to cause adverse effects on reproduction and development in humans. The CERHR Expert Panel on Bisphenol A completed its evaluation in August 2007. CERHR selected bisphenol A for evaluation because of the: widespread human exposure; public concern for possible health effects from human exposures; high production volume; evidence of reproductive and developmental toxicity in laboratory animal studies Bisphenol A (CAS RN: 80-05-7) is a high production volume chemical used primarily in the production of polycarbonate plastics and epoxy resins. Polycarbonate plastics are used in some food and drink containers; the resins are used as lacquers to coat metal products such as food cans, bottle tops, and water supply pipes. To a lesser extent bisphenol A is used in the production of polyester resins, polysulfone resins, polyacrylate resins, and flame retardants. In addition, bisphenol A is used in the processing of polyvinyl chloride plastic and in the recycling of thermal paper. Some polymers used in dental sealants and tooth coatings contain bisphenol A. The primary source of exposure to bisphenol A for most people is assumed to occur through the diet. While air, dust, and water (including skin contact during bathing and swimming) are other possible sources of exposure, bisphenol A in food and beverages accounts for the majority of daily human exposure. The highest estimated daily intakes of bisphenol A in the general population occur in infants and children. The results of this bisphenol A evaluation are published in an NTP-CERHR Monograph that includes the (1) NTP Brief and (2) Expert Panel Report on the Reproductive and Developmental Toxicity of Bisphenol A. Additional information related to the evaluation process, including the peer review report for the NTP Brief and public comments received on the draft NTP

  4. Cocaine: Pharmacology, Effects, and Treatment of Abuse. National Institute on Drug Abuse Research Monograph 50.

    Science.gov (United States)

    Grabowski, John, Ed.

    This monograph consists of eight papers which refer in one way or another to the pharmacology of cocaine. The papers are: (1) Cocaine 1984: Introduction and Overview" (John Grabowski); (2) "Cocaine: A Growing Public Health Problem" (Edgar H. Adams and Jack Durell); (3) "Neural Mechanisms of the Reinforcing Action of…

  5. NTP-CERHR monograph on the potential human reproductive and developmental effects of hydroxyurea.

    Science.gov (United States)

    2008-10-01

    The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an evaluation of the potential for hydroxyurea to cause adverse effects on reproduction and development in humans. Hydroxyurea is a drug used to treat cancer, sickle cell disease, and thalassemia. It is the only treatment for sickle cell disease in children, aside from blood transfusion and, in severe cases, hematopoietic stem cell transplantation. Hydroxyurea is FDA-approved for use in adults with sickle cell anemia to reduce the frequency of painful crises and the need for blood transfusions. Hydroxyurea may be given to children and adults with sickle cell disease for an extended period of time or for repeated cycles of therapy. Treatment with hydroxyurea is associated with known side effects such as cytotoxicity and myelosuppression, and hydroxyurea is genotoxic (can damage DNA). CERHR selected hydroxyurea for evaluation because of: its increasing use for treatment of sickle cell disease in children and adults, knowledge that it inhibits DNA synthesis and is cytotoxic, and published evidence of reproductive and developmental toxicity in rodents. The results of this evaluation are published in the NTP-CERHR Monograph on Hydroxyurea, which includes the NTP Brief and Expert Panel Report on the Reproductive and Developmental Toxicity of Hydroxyurea. Additional information related to the evaluation process, including public comments received on the draft NTP Brief and the final expert panel report, are available on the CERHR website (http:// cerhr.niehs.nih.gov/). See hydroxyurea under "CERHR Chemicals" on the homepage or go directly to http://cerhr.niehs.nih.gov/chemicals/hydroxyurea/hydroxyurea-eval.html). The NTP reached the following conclusions on the possible effects of exposure to hydroxyurea on human reproduction or development. The possible levels of concern, from lowest to highest, are negligible concern, minimal concern, some concern, concern

  6. Unconventional Methods and Materials for Preparing Educational Administrators. ERIC/CEM-UCEA Series on Administrator Preparation. ERIC/CEM State-of-the-Knowledge Series, Number Fifteen. UCEA Monograph Series, Number Two.

    Science.gov (United States)

    Wynn, Richard

    In this monograph, the author describes the variety of new and innovative instructional methods and materials being used to prepare educational administrators. Because the subject is new and the nomenclature surrounding it imprecise, the author defines his terms. An outline of the history of unconventional instructional methods and the rationale…

  7. Preparing Educational Leaders: A Review of Recent Literature. ERIC/CEM-UCEA Series on Administrator Preparation. ERIC/CEM/ State-of-the-Knowledge Series, Number Fourteen. UCEA Monograph Series, Number One.

    Science.gov (United States)

    Farquhar, Robin H.; Piele, Philip K.

    In this monograph, the authors provide a general overview of recent literature on administrator preparation programs. Ten chapters parallel the major interrelated components of an administrator preparation program: Program content, program structure, recruitment and selection, instructional approaches, field-related experiences, student research,…

  8. Training-in-Common for Educational, Public, and Business Administrators. ERIC/CEM-UCEA Series on Administrator Preparation. ERIC/CEM State-of-the-Knowledge Series, Number Seventeen. UCEA Monograph Series, Number Four.

    Science.gov (United States)

    Miklos, Erwin

    In this monograph, the author assesses the progress that has been made toward the development of in-common programs for preparing administrators to serve in a variety of institutional settings. After outlining the assumptions, rationales, and strategies behind attempts to institute interdisciplinary administrator training programs, the author…

  9. Emergent Practices in the Continuing Education of School Administrators. ERIC/CEM-UCEA Series on Administrator Preparation. ERIC/CEM State-of-the-Knowledge Series, Number Sixteen. UCEA Monograph Series, Number Three.

    Science.gov (United States)

    Lutz, Frank W.; Ferrante, Reynolds

    In this monograph, the authors describe the shortcomings of traditional approaches to continuing education of administrators and examine the extent to which innovations are being attempted in present practices. The authors note that, in print and in practice, continuing education of administrators has failed to develop to the extent that it can be…

  10. New Approaches to Recruitment and Selection of Educational Administrators. ERIC/CEM-UCEA Series on Administrator Preparation. ERIC/CEM State-of-the-Knowledge Series, Number Eighteen. UCEA Monograph Series, Number Five.

    Science.gov (United States)

    Stout, Robert T.

    In this monograph, the author claims there is a need for administrators who are responsive to legitimate demands for educational change. He reviews the shortcomings of contemporary American educational systems and traditional procedures for selecting and preparing administrators -- a group noted for its size and homogeneity. The author contends…

  11. Subjective Well-Being In Later Life: 20 years after the Butterworths monograph series on individual and population aging.

    Science.gov (United States)

    Stones, Michael; Kozma, Albert; McNeil, Kevin; Worobetz, Sarah

    2011-09-01

    This article discusses developments in theory and research on happiness two decades after publication of Psychological Well-Being in Later Life (Butterworths, 1991) by Albert Kozma, Michael Stones, and Kevin McNeil. Major empirical advances include new knowledge about contributions to happiness resulting from genetically related effects and personality. Personality traits have stronger relationships with happiness than was apparent 20 years ago and contribute to covariance between happiness and some of its predictors. Evolving emphases in research include the ways in which genetically related effects influence how people shape, and react to, their environment.

  12. Students in Transition: Research and Practice in Career Development. The First-Year Experience Monograph Series No. 55

    Science.gov (United States)

    Gore, Paul A., Jr., Ed.; Carter, Louisa P., Ed.

    2011-01-01

    Offering a primer on action research methodologies and examples of practice, "Students in Transition: Research and Practice in Career Development" responds to a dual challenge facing career development educators--designing cutting-edge career development interventions and demonstrating their effectiveness. Overviews of quantitative and qualitative…

  13. The Honors Thesis: A Handbook for Honors Directors, Deans, and Faculty Advisors. National Collegiate Honors Council Monograph Series

    Science.gov (United States)

    Anderson, Mark; Lyons, Karen; Weiner, Norman

    2014-01-01

    This handbook is intended to help all those who design, administer, and implement honors thesis programs--honors directors, deans, staff, faculty, and advisors--evaluate their thesis programs, solve pressing problems, select more effective requirements or procedures, or introduce an entirely new thesis program. The authors' goal is to provide…

  14. 21 CFR 330.11 - NDA deviations from applicable monograph.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false NDA deviations from applicable monograph. 330.11... EFFECTIVE AND NOT MISBRANDED Administrative Procedures § 330.11 NDA deviations from applicable monograph. A new drug application requesting approval of an OTC drug deviating in any respect from a monograph that...

  15. Psychotherapy and Counseling in the Treatment of Drug Abuse [Technical Review] (Rockville, Maryland, May 18-19, 1989). National Institute on Drug Abuse Research Monograph Series 104.

    Science.gov (United States)

    Onken, Lisa Simon; Blaine, Jack D.

    This monograph is based on the papers from a technical review. These papers are included: (1) Psychotherapy and Counseling Research in Drug Abuse Treatment: Questions, Problems, and Solutions (Lisa Onken, Jack Blaine); (2) Psychotherapy and Counseling for Methadone-Maintained Opiate Addicts: Results of Research Studies (George Woody, A. T.…

  16. The Impact of Socioeconomic Development and Ecological Change on Health and Nutrition in Latin America. Cornell International Nutrition Monograph Series, Number 9 (1981).

    Science.gov (United States)

    Solimano, Giorgio R.; Chapin, Georganne

    This monograph presents an examination of patterns which emerge from the interrelationship between development, environment, and health and nutrition in Latin America. First, the authors consider the components of this interrelationship, discussing the inseparability of health problems such as malnutrition, fecally-borne and parasitic diseases,…

  17. Transfer Students in Higher Education: Building Foundations for Policies, Programs, and Services that Foster Student Success. The First-Year Experience Monograph Series No. 54

    Science.gov (United States)

    Poisel, Mark Allen, Ed.; Joseph, Sonya, Ed.

    2011-01-01

    "Transfer Students in Higher Education" presents what individuals know about transfer students, addresses assumptions and myths about the transfer experience, and explores the changing demographics of this student group. Adopting a student-centered approach, the monograph offers strategies to begin (and continue) the work of serving students and…

  18. Writing on Your Feet: Reflective Practices in City as Text™. A Tribute to the Career of Bernice Braid. National Collegiate Honors Council Monograph Series

    Science.gov (United States)

    Long, Ada, Ed.

    2014-01-01

    City as Text™ (CAT) is one of the earliest structural forms of experiential learning created and practiced in the United States. This monograph explores the centrality of writing in the process of active learning, focusing primarily on the Faculty Institutes and Honors Semesters that foster CAT experiences. All manifestations of this pedagogical…

  19. The Economic Value of Breastfeeding (With Results from Research Conducted in Ghana and the Ivory Coast). Cornell International Nutrition Monograph Series Number 6.

    Science.gov (United States)

    Greiner, Ted; And Others

    This monograph focuses attention on economic considerations related to infant feeding practices in developing countries. By enlarging on previous methodologies, this paper proposes to improve the accuracy of past estimates of the economic value of human milk, or more specifically, the practice of breastfeeding. The theoretical model employed…

  20. The Decline in Breastfeeding: An Analysis of the Role of the Nestle Corporation from Two Perspectives. Cornell International Nutrition Monograph Series, Number 11 (1982).

    Science.gov (United States)

    Campbell, Carolyn E.

    An attempt is made to analyze the ascendancy of formula feeding of infants in terms of the conflicting ideologies of Marxism and capitalism. The decline of breastfeeding is traced, and is linked with the interrelated phenomena of free market economics and the domination of women by men in Western society. The monograph has two sections:…

  1. The Economic Value of Breastfeeding (With Results from Research Conducted in Ghana and the Ivory Coast). Cornell International Nutrition Monograph Series Number 6.

    Science.gov (United States)

    Greiner, Ted; And Others

    This monograph focuses attention on economic considerations related to infant feeding practices in developing countries. By enlarging on previous methodologies, this paper proposes to improve the accuracy of past estimates of the economic value of human milk, or more specifically, the practice of breastfeeding. The theoretical model employed…

  2. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of 1-Bromopropane (1-BP).

    Science.gov (United States)

    2003-10-01

    The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an evaluation of the potential for 1-bromopropane to cause adverse effects on reproduction and development in humans. 1-Bromopropane was selected for evaluation due to recent consideration of 1-bromopropane as a replacement chemical for hydrochlorofluorocarbons and chlorinated solvents. 1-Bromopropane is used in spray adhesives and in cleaning metal and electronic components; as a solvent for fats, waxes, or resins; and as an intermediate in the synthesis of pharmaceuticals, insecticides, quaternary ammonium compounds, flavors, or fragrances. The results of this evaluation on 1-brompropane are published in a NTP-CERHR monograph which includes: 1) the NTP Brief, 2) the Expert Panel Report on the Reproductive and Developmental Toxicity of 1-Bromopropane, and 3) public comments received on the Expert Panel Report. As stated in the NTP Brief, the NTP reached the following conclusions regarding the possible effects of exposure to 1-bromopropane on human development and reproduction. No data were available on 1-bromopropane exposures in the general US population. Therefore, conclusions were based on the available occupational exposure data and on studies in humans and laboratory animals. First, there is serious concern for reproductive and developmental effects at the upper end of the human occupational exposure range (18-381 ppm). Adverse developmental and/or reproductive effects have been reported in animal studies at exposure levels of >/=200 ppm. Second, there is minimal concern for reproductive and developmental effects when humans are exposed at the lower end of the human occupational exposure range (0.04-0.63 ppm). This level is at least 300- fold lower than the no effect level identified from reproductive studies in laboratory animals. These conclusions are based upon limited occupational inhalation exposure data. It is likely that worker exposures

  3. Practical Public Relations: Effective PR Techniques for School Library/Media Specialists. Monograph Series No. 5.

    Science.gov (United States)

    Behm, Mary W., Ed.

    This handbook of publicity ideas suggests activities and themes to highlight services and resources of school media centers, including approaches to students, faculty, administration, and the community at large. A 14-item annotated bibliography and six mailing list addresses are provided as additional sources for ideas. Clip art illustrations…

  4. AMTA Monograph Series - Effective Clinical Practice in Music Therapy Early Childhood and School Age Educational Settings

    Science.gov (United States)

    Humpal, Marcia Earl, Ed.; Colwell, Cynthia, Ed.

    2006-01-01

    Educators, families, and media in increasing numbers are recognizing the unique role music plays in young children's development. More and more daycare, preschool, and early intervention centers offer employment opportunities that reflect the needs and attitudes of our ever-changing society. Furthermore, Federal and state regulations, a changing…

  5. Effective Feature Preprocessing for Time Series Forecasting

    DEFF Research Database (Denmark)

    Zhao, Junhua; Dong, Zhaoyang; Xu, Zhao

    2006-01-01

    Time series forecasting is an important area in data mining research. Feature preprocessing techniques have significant influence on forecasting accuracy, therefore are essential in a forecasting model. Although several feature preprocessing techniques have been applied in time series forecasting...... performance in time series forecasting. It is demonstrated in our experiment that, effective feature preprocessing can significantly enhance forecasting accuracy. This research can be a useful guidance for researchers on effectively selecting feature preprocessing techniques and integrating them with time...... series forecasting models....

  6. Volterra Series Based Distortion Effect

    DEFF Research Database (Denmark)

    Agerkvist, Finn T.

    2010-01-01

    A large part of the characteristic sound of the electric guitar comes from nonlinearities in the signal path. Such nonlinearities may come from the input- or output-stage of the amplier, which is often equipped with vacuum tubes or a dedicated distortion pedal. In this paper the Volterra series e...

  7. Developing School and Community Partnerships To Meet the Needs of Students with Challenging Behaviors. CASE/CCBD Mini-Library Series on Safe, Drug-Free, and Effective Schools.

    Science.gov (United States)

    Sommerville, Don; McDonald, Shirley

    Part of a series on safe, drug-free, and effective schools, this monograph discusses developing school and community partnerships to assist students with behavior problems. It begins by offering a general description of the student with challenging behaviors and the determination of the students placement in the least restrictive environment.…

  8. Analyzing Workforce Education. Monograph.

    Science.gov (United States)

    Texas Community & Technical Coll. Workforce Education Consortium.

    This monograph examines the issue of task analysis as used in workplace literacy programs, debating the need for it and how to perform it in a rapidly changing environment. Based on experiences of community colleges in Texas, the report analyzes ways that task analysis can be done and how to implement work force education programs more quickly.…

  9. Multiple Primary Cancer Monograph

    Science.gov (United States)

    To identify groups of cancer survivors that are at increased risk for multiple primary cancers, investigators led an effort to provide the first comprehensive population-based analysis of the risk of subsequent cancer in the U.S., resulting in a monograph.

  10. Real exchange-rate adjustment and the welfare effects of oil-price decontrol. [Monograph

    Energy Technology Data Exchange (ETDEWEB)

    Krugman, P.

    1981-01-01

    Conventional analysis of the welfare effects of US oil price regulation in the 1970s focuses on the deadweight losses in the oil market. This paper argues that such analysis substantially underrates the benefits from decontrolling prices because decontrol will lead to an improvement in the US terms of trade with respect to other oil-importing countries. A simple model of the relationship between oil decontrol and the terms of trade is developed, and the impact is calculated for plausible parameter values. The results suggest that the terms of trade benefits are several times larger than the benefits as conventionally measured. 4 references, 1 figure, 5 tables.

  11. Clinical roundtable monograph: effective management of quality of life in metastatic breast cancer.

    Science.gov (United States)

    Christopher, Twelves; Gradishar, William J; O'Shaughnessy, Joyce A; Bramsen, Betsy; Lurie, Robert H

    2014-02-01

    Quality of life is accepted as an important consideration in the management of patients with metastatic breast cancer, which remains incurable. Recent clinical trials of newer agents, such as eribulin and trastuzumab emtansine, have incorporated quality of life analyses. Quality of life is impacted by multiple patient-related, disease-related, and treatment-related factors. Therapies most beneficial for maintaining or improving quality of life include those that can effectively reduce tumor burden and tumor-related symptoms, but have toxicity profiles that are well tolerated and easily managed. Overall outcomes of patients with metastatic breast cancer improve when therapy is focused not only on the disease itself, but also on the goals of minimizing diseaserelated and treatment-related symptoms. A paradigm shift now reflected in major guidelines is the incorporation of palliative care strategies earlier in the course of metastatic disease management. The selection and sequence of treatments should be made in cooperation with the patient and after consideration of her particular priorities.

  12. NTP-CERHR monograph on the potential human reproductive and developmental effects of acrylamide.

    Science.gov (United States)

    2005-02-01

    Tanii, 1985). It can react with DNA in vitro to produce a guanine derivative N7-(2-carbamoyl-2-hydroxyethyl)guanine(Gamboa da Costa et al., 2003; Segerback et al., 1995). In vivo, administration of acrylamide to rats and mice produces low levels of N7-(2-carbamoyl-2-hydroxyethyl)guanine (Gamboa da Costa et al., 2003; Segerback et al., 1995).Acrylamide induces a characteristic peripheral neurotoxicity in animals and man(Spencer and Schaumburg, 1974a, b, 1975). This toxicity manifests itself as a distal to proximal loss of nerve function and dying back of cells. Acrylamide also effects rodent reproduction, namely smaller litter size. At elevated acrylamide doses other reproductive effects are seen, likely as a consequence of the neurotoxicity. Acrylamide is carcinogenic in drinking water studies in laboratory rats (Friedman et al.,1995; Johnson et al., 1986). In male rats, it induces tumors of the tunica vaginalis testes and the thyroid, while in females, it induces mammary fibroadenomas and thyroid tumors(Friedman et al., 1995). The mechanism for this tumorigenicity is unclear, although interaction with the dopamine receptor has been postulated as well as genotoxicity (Tyland Friedman, 2003). If the mechanism were genotoxicity, then conversion of acrylamide to glycidamide is directly proportional to carcinogenic activity.Understanding the mechanism of tumorigenicity is important, since conventional risk assessment techniques place the order of magnitude of the risk at approximately 10-3 with exposures of 70 μg/ day.The relative contributions of acrylamide and glycidamide in the mode of action of acrylamide are the subject of debate and current research. Understanding the conversion of acrylamide to glycidamide and differences that may occur between species, exposure route, and dose are important considerations in assessing the risk of the possible effects of acrylamide exposures in the diet, in consumer products, and in the workplace.The primary objectives of this study

  13. Higher Education in the Republic of Moldova. Monographs on Higher Education.

    Science.gov (United States)

    Tiron, Stefan; Arion, Valentin; Paiu, Mihai; Scalini, Vitalie; Stan, Victor

    This monograph parallels others in the "Monographs" series, allowing easy comparisons among the higher education systems of Europe. The volume describes the development of the higher education system in the Republic of Moldava and analyzes its legislative framework and administrative structures. It outlines steps on the academic career ladder and…

  14. Fourier series

    CERN Document Server

    Tolstov, Georgi P

    1962-01-01

    Richard A. Silverman's series of translations of outstanding Russian textbooks and monographs is well-known to people in the fields of mathematics, physics, and engineering. The present book is another excellent text from this series, a valuable addition to the English-language literature on Fourier series.This edition is organized into nine well-defined chapters: Trigonometric Fourier Series, Orthogonal Systems, Convergence of Trigonometric Fourier Series, Trigonometric Series with Decreasing Coefficients, Operations on Fourier Series, Summation of Trigonometric Fourier Series, Double Fourie

  15. Effective Feature Preprocessing for Time Series Forecasting

    DEFF Research Database (Denmark)

    Zhao, Junhua; Dong, Zhaoyang; Xu, Zhao

    2006-01-01

    Time series forecasting is an important area in data mining research. Feature preprocessing techniques have significant influence on forecasting accuracy, therefore are essential in a forecasting model. Although several feature preprocessing techniques have been applied in time series forecasting......, there is so far no systematic research to study and compare their performance. How to select effective techniques of feature preprocessing in a forecasting model remains a problem. In this paper, the authors conduct a comprehensive study of existing feature preprocessing techniques to evaluate their empirical...... performance in time series forecasting. It is demonstrated in our experiment that, effective feature preprocessing can significantly enhance forecasting accuracy. This research can be a useful guidance for researchers on effectively selecting feature preprocessing techniques and integrating them with time...

  16. Tracking and Treating Mobile Populations. The TB Net System. Migrant Clinicians Network Monograph Series. = El Sistema de Red para la TB.

    Science.gov (United States)

    Migrant Clinicians Network, Inc., Austin, TX.

    A comprehensive tracking and referral network that helps provide continuity of care for mobile populations with active tuberculosis (TB) or TB infection is considered essential for effective treatment of TB. However, the interstate referral system that exists between state health departments has been highly inefficient for serving migrant…

  17. Distributed series resistance effects in solar cells

    DEFF Research Database (Denmark)

    Nielsen, Lars Drud

    1982-01-01

    A mathematical treatment is presented of the effects of one-dimensional distributed series resistance in solar cells. A general perturbation theory is developed, including consistently the induced spatial variation of diode current density and leading to a first-order equivalent lumped resistance...

  18. Monograph of Coccinia (Cucurbitaceae).

    Science.gov (United States)

    Holstein, Norbert

    2015-01-01

    This monograph deals with all 95 names described in the Cucurbitaceae genus Coccinia and recognizes 25 species. Taxonomic novelties are Cocciniaadoensisvar.aurantiaca (C.Jeffrey) Holstein, stat. nov., Cocciniasessilifoliavar.variifolia (A.Meeuse) Holstein, stat. nov., and Cocciniaadoensisvar.jeffreyana Holstein, var. nov. For the 25 species 3157 collections were examined, of which 2024 were georeferenced to produce distribution maps. All species are distributed in sub-Saharan Africa with one species, Cocciniagrandis, extending from Senegal in West Africa east to Indonesia and being naturalized on Pacific Islands, in Australia, the Caribbean, and South America. Coccinia species are dioecious creepers or climbers with simple or bifid tendrils that occupy a range of habitats from arid scrubland, woodlands to lowland rainforest and mist forest. The corolla of Coccinia species is sympetalous, usually pale yellow to orange, and 1 to 4.5 cm long. Pollination is by bees foraging for pollen or nectar. After pollination, the developing ovary often exhibits longitudinal mottling, which usually disappears during maturation. All species produce berries with a pericarp in reddish colors (orange-red through to scarlet red), hence the generic name. The globose to cylindrical fruits contain numerous grayish-beige flat to lenticular seeds. Chromosome numbers are 2n = 20, 24, and 22 + XX/XY. Many Coccinia species are used for food, either as roasted tubers, greens as spinach, or the fruits as vegetables. Medicinal value is established in Cocciniagrandis, of which leaves and sap are used against diabetes.

  19. AMTA Monograph Series. Effective Clinical Practice in Music Therapy Medical Music Therapy for Pediatrics in Hospital Settings

    Science.gov (United States)

    American Music Therapy Association, 2008

    2008-01-01

    The impact of hospitalization on children and their families is becoming more clearly understood in today's changing healthcare environment. Pediatric inpatient services are focused on children with more critical illnesses, shorter hospital stays, and a culture of family-centered care. This publication clearly exemplifies the role of music…

  20. AMTA Monograph Series. Effective Clinical Practice in Music Therapy: Music Therapy for Children, Adolescents, and Adults with Mental Disorders

    Science.gov (United States)

    Crowe, Barbara, Ed.

    2007-01-01

    Whether new to the profession or an experienced clinician, this text provides a wealth of state-of-the-art information for undergraduates, graduates and professionals. This volume covers the wide range of mental disorder diagnoses and addresses specific populations such as forensic and drug and alcohol rehabilitation. How music therapy is used…

  1. AMTA Monograph Series. Effective Clinical Practice in Music Therapy Medical Music Therapy for Pediatrics in Hospital Settings

    Science.gov (United States)

    American Music Therapy Association, 2008

    2008-01-01

    The impact of hospitalization on children and their families is becoming more clearly understood in today's changing healthcare environment. Pediatric inpatient services are focused on children with more critical illnesses, shorter hospital stays, and a culture of family-centered care. This publication clearly exemplifies the role of music…

  2. Could EU herbal monographs contribute to Malta's treatment armamentarium?

    Science.gov (United States)

    Micallef, B; Attard, E; Serracino-Inglott, A; Borg, J J

    2015-03-15

    Ten years have passed since Directive 2004/24/EC regulating herbal medicinal products across the EU were published. The directive created the Committee on Herbal Medicinal Products within the European Medicines Agency whose remit includes the creation and publishing of official EU monographs on herbal medicinal products. These monographs include the official uses of the products and their evidence for efficacy and safety. To this effect, we are interested in analysing the potential impact herbal product EU monographs could have on the therapeutic treatment options available for prescribers in Malta. Therefore our aim was two-fold. First, to rationalise the spread of indications of the herbal substances listed in the community herbal monograph inventory and subsequently determine if these herbal substances could potentially contribute to the treatment options available in our local scenario (Malta). 128 EU monographs were analysed resulting in a total of 230 indications which subsequently codified into 42 unique ATC codes. The Malta Medicines List contains 1456 unique ATC codes. Comparative analysis of the Malta Medicines List revealed that the 21 therapeutic areas had 4 or less pharmaceutically used substances (5th level ATC codes) registered and therefore in our opinion are areas with limited therapeutic choice. The following 4 therapeutic areas, A05 bile and liver therapy, A13 tonics, A15 appetite stimulants and D03 preparations for treatment of wounds and ulcers, could potentially benefit from the registration of herbal medicinal products according to the EU herbal monographs. If such registration is effected the aforementioned areas would no longer be considered limited because more than 4 therapeutic choices would be available to prescribers. This study is the first study across the EU to analyse the potential impact of published EU herbal monographs on therapeutic coverage in an EU member state and confirms the notion that herbal products could potentially

  3. Report on carcinogens monograph on 1-bromopropane.

    Science.gov (United States)

    2013-09-01

    The National Toxicology Program conducted a cancer evaluation on 1 bromopropane for possible listing in the Report on Carcinogens (RoC). The cancer evaluation is captured in the RoC monograph, which was peer reviewed in a public forum. The monograph consists of two components: (Part 1) the cancer evaluation, which reviews the relevant scientific information, assesses its quality, applies the RoC listing criteria to the scientific information, and provides the NTP recommendation for listing status for 1 bromopropane in the RoC, and (Part 2) the substance profile proposed for the RoC, containing the NTP's listing status recommendation, a summary of the scientific evidence considered key to reaching that decision, and data on properties, use, production, exposure, and Federal regulations and guidelines to reduce exposure to 1-bromopropane. This monograph provides an assessment of the available scientific information on 1 bromopropane, including human exposure and properties, disposition and toxicokinetics, cancer studies in experimental animals, and studies of mechanisms and other related effects, including relevant toxicological effects, genetic toxicology, and mechanisms of carcinogenicity. From this assessment, the NTP recommended that 1 bromopropane be listed as reasonably anticipated to be a human carcinogen in the RoC based on sufficient evidence from studies in experimental animals, which found inhalation exposure to 1-bromopropane caused skin tumors in male rats, large intestine tumors in female and male rats, and lung tumors in female mice. Also noted was that 1 bromopropane, either directly or via reactive metabolites, caused molecular alterations that typically are associated with carcinogenesis, including genotoxicity, oxidative stress, and glutathione depletion. These alterations, observed in mainly in vitro and toxicity studies in rodents, are relevant to possible mechanisms of human carcinogenicity and support the relevance of the cancer studies in

  4. Report on carcinogens monograph on cumene.

    Science.gov (United States)

    2013-09-01

    The National Toxicology Program conducted a cancer evaluation on cumene for possible listing in the Report on Carcinogens (RoC). The cancer evaluation is captured in the RoC monograph, which was peer reviewed in a public forum. The monograph consists of two components: (Part 1) the cancer evaluation, which reviews the relevant scientific information, assesses its quality, applies the RoC listing criteria to the scientific information, and provides the NTP recommendation for listing status for cumene in the RoC, and (Part 2) the substance profile proposed for the RoC, containing the NTP's listing status recommendation, a summary of the scientific evidence considered key to reaching that decision, and data on properties, use, production, exposure, and Federal regulations and guidelines to reduce exposure to cumene. This monograph provides an assessment of the available scientific information on cumene, including human exposure and properties, disposition and toxicokinetics, cancer studies in experimental animals, and studies of mechanisms and other related effects, including relevant toxicological effects, genetic toxicology, and mechanisms of carcinogenicity. From this assessment, the NTP recommended that cumene be listed as reasonably anticipated to be a human carcinogen in the RoC based on sufficient evidence from studies in experimental animals, which found that cumene exposure caused lung tumors in male and female mice and liver tumors in female mice. Several proposed mechanisms of carcinogenesis support the relevance to humans of the lung and liver tumors observed in experimental animals. Specifically, there is evidence that humans and experimental animals metabolize cumene through similar metabolic pathways. In addition, mutations of the K-ras oncogene and p53 tumor-suppressor gene observed in cumene-induced lung tumors in mice, along with altered expression of many other genes, resemble molecular alterations found in human lung and other cancers.

  5. 运用专题导向学习进行小论文写作课程之成效探讨%The Study to Explore the Effect of the Curriculum of Essay Writing in Monograph-oriented Learning

    Institute of Scientific and Technical Information of China (English)

    张碧如; 姚湘玲; 吕秋萍

    2011-01-01

    台湾技职教育新课程的规划中,将"专题制作"纳入校定必修课程,本研究旨在探讨运用专题导向学习,利用数字学习平台以专题制作课程结合小论文写作之学习成效。研究发现专题导向学习的教学活动受到大部分学生的喜爱与欢迎,并认为可以增进认知、情意、技能及小论文写作等的能力,故专题导向学习值得在教学中推广。在专题制作课程实施过程中也发现,学习过程中提供学生合作解决问题的机会,培养使用资料搜集的技能,对于提升学生的专题相关知识及网络的使用能力等都具有正向的效果。%In the new curriculum of technical and vocational education in Taiwan,monograph has been subsumed both required and important subject to train the students to have autonomy and the ability of integration.Further,with the progress and development of computer technology,the students had rich and diverse learning situations,so this study was to investigate the learning effect of applying monograph-oriented learning which combined project making course and essay writing on e-learning platform.The results of this study showed that monograph-oriented teaching was very popular with most of the students,and they thought that it could improve cognition,affection,ability and writing ability on essay.Therefore,monograph-oriented teaching is worth promoting in teaching.We also found that the teaching not only offered the students chances of solving problem cooperatively and developing the ability of collecting information but upgraded the knowledge about the monograph,and the ability of Internet using positively.

  6. The Research Use of Astronomical Monographs

    Science.gov (United States)

    Abt, Helmut A.

    2014-04-01

    I explored the use of astronomical monographs used for research. After scanning 135 monographs (excluding conference proceedings and textbooks) listed in 2000-2003 issues of Physics Today and counting citations of them in 2000-2013 in ADS (Astrophysics Data System), I found that 67% of the monographs received fewer than 2 citations per year. The average citation rate for the 135 monographs is statistically the same as for ApJ papers. In contrast, only 41% of the ApJ papers produce fewer than 2 citations per year. ADS also counts the number of times each book or paper is read on-line. The average in 14 years is 181 ± 27 times for the monographs and 633 ± 47 times for ApJ papers. The total numbers of citations in 14 years for the monographs ranged from 0 to 711. I explored reasons for this range and only learned that it did not depend on (1) the numbers of book reviews published or (2) the scientific stature of the authors. I am unable to predict whether a monograph will be successful or not. The decreasing of references to monographs seems to be due to (1) monographs becoming so expensive that individuals and libraries cannot afford many of them, (2) readers seeming to prefer concise reviews, such as online searches and the Annual Reviews, and (3) most of the monographs having not been available free online.

  7. A convergent series for the QED effective action.

    Science.gov (United States)

    Cho, Y M; Pak, D G

    2001-03-05

    The one-loop effective action of QED obtained by Heisenberg and Euler and by Schwinger has been expressed by an asymptotic perturbative series which is divergent. In this Letter we present a nonperturbative but convergent series of the effective action. With the convergent series we establish the existence of the manifest electric-magnetic duality in the one-loop effective action of QED.

  8. A Unified Method of Finding Laplace Transforms, Fourier Transforms, and Fourier Series. [and] An Inversion Method for Laplace Transforms, Fourier Transforms, and Fourier Series. Integral Transforms and Series Expansions. Modules and Monographs in Undergraduate Mathematics and Its Applications Project. UMAP Units 324 and 325.

    Science.gov (United States)

    Grimm, C. A.

    This document contains two units that examine integral transforms and series expansions. In the first module, the user is expected to learn how to use the unified method presented to obtain Laplace transforms, Fourier transforms, complex Fourier series, real Fourier series, and half-range sine series for given piecewise continuous functions. In…

  9. The Audit Committee. AGB Effective Committee Series

    Science.gov (United States)

    Staisloff, Richard L.

    2011-01-01

    This publication is part of an Association of Governing Boards of Universities and Colleges (AGB) series devoted to strengthening the role of key standing committees of governing boards. While there is no optimum committee system for institutions of higher education, certain principles, practices, and procedures prevail. The best practices…

  10. The Facilities Committee. AGB Effective Committee Series

    Science.gov (United States)

    Kaiser, Harvey H.

    2012-01-01

    This publication is part of an Association of Governing Boards of Universities and Colleges (AGB) series devoted to strengthening the role of key standing committees of governing boards. While there is no optimum committee system for institutions of higher education, certain principles, practices, and procedures prevail. The best practices…

  11. The Compensation Committee. AGB Effective Committee Series

    Science.gov (United States)

    Hyatt, Thomas K.

    2013-01-01

    This publication is part of an Association of Governing Boards of Universities and Colleges (AGB) series devoted to strengthening the role of key standing committees of governing boards. While there is no optimum committee system for institutions of higher education, certain principles, practices, and procedures prevail. The best practices…

  12. The Facilities Committee. AGB Effective Committee Series

    Science.gov (United States)

    Kaiser, Harvey H.

    2012-01-01

    This publication is part of an Association of Governing Boards of Universities and Colleges (AGB) series devoted to strengthening the role of key standing committees of governing boards. While there is no optimum committee system for institutions of higher education, certain principles, practices, and procedures prevail. The best practices…

  13. The Investment Committee. AGB Effective Committee Series

    Science.gov (United States)

    Yoder, Jay A.

    2011-01-01

    This publication is part of an AGB series devoted to strengthening the role of key standing committees of governing boards. While there is no optimum committee system for institutions of higher education, certain principles, practices, and procedures prevail. The best practices included in this text support the objectives of board committees:…

  14. A dose-response study in animals to evaluate the anticoagulant effect of the stage 2 unfractionated heparin USP monograph change.

    Science.gov (United States)

    Honchel, R; Carraway, J; Gopee, N; Callicott, R; Chen, J; Patton, R; Xu, Q; Zalkkar, J; Laniyonu, A; Krefting, I; Cato, M; Robie-Suh, K; Rieves, R

    2011-08-01

    The United States Pharmacopeia (USP) monograph for unfractionated heparin (UFH) was revised in October 2009. This revision was anticipated, based upon in vitro tests, to reduce UFH potency by approximately 10%. To study the potential in vivo consequences of the monograph change, we evaluated activated partial thromboplastin time (aPTT) and activated clotting time (ACT) responses in animals. Female mini-pigs and monkeys (n=8/species) were administered intravenously 60, 54, 48, or 42 U/kg and 50, 45, 40, or 35 U/kg "old" (pre-USP revision) UFH, respectively, in a Williams 4×4 crossover design. Blood samples for aPTT and ACT were collected at 15 min after dosing. The same study design was then repeated using "new" (post-USP revision) UFH. Mean "new" UFH aPTT and ACT values were generally lower than those for "old" UFH although individual animal responses varied considerably. The aPTT and ACT response was generally dose-proportional for both "old" and "new" UFH. These studies indicate that the USP monograph alteration for UFH may result in a modest reduction in the anticoagulant response across a population, but the variability in animal responses underscores the importance of individualization of clinical UFH dosing and the importance of anticoagulant test monitoring. Published by Elsevier Inc.

  15. Systematic organization of medicinal plant information: a monograph template proposal

    Directory of Open Access Journals (Sweden)

    Ana C.B. Carvalho

    2014-01-01

    Full Text Available The use of medicinal plants in Brazil is widespread and is supported by public policies; it has the objective of providing the population with safe and effective herbal medicines of adequate quality. An action in these policies is to develop medicinal plant monographs to gather published information and decide which medicinal plants should be financed by the Brazilian government and distributed by the public health system. Currently, the monographs published worldwide do not present unified information regarding medicinal plants, and generally, they do not cover enough requirements for herbal medicine registration. The aim of this study is to develop a monograph model with standardized information not only about botany, agronomy, quality control, safety, and efficacy but also about relating regulatory aspects that support herbal medicine regulation. The development of standardized monographs favors the fast authorization and distribution of herbal medicines in the public system. The model also points out the lacking studies that should be carried out to supplement the necessary regulatory information of medicinal plants.

  16. Citation Analysis Shows Promise as an Effective Tool for Monograph Collection Citation Analysis Shows Promise as an Effective Tool for Monograph Collection Development. A Review of: Enger, K. B. (2009. Using citation analysis to develop core book collections in academic libraries. Library & Information Science Research, 31(2, 107‐112.

    Directory of Open Access Journals (Sweden)

    Scott Marsalis

    2010-06-01

    Full Text Available Objective – To test whether acquiring books written by authors of highly cited journal articles is an effective method for building a collection in the social sciences.Design – Comparison Study.Setting – Academic library at a public university in the US.Subjects – A total of 1,359 book titles, selected by traditional means (n=1,267 or based on citation analysis (n=92.Methods – The researchers identified highly‐ranked authors, defined as the most frequently cited authors publishing in journals with an impact factor greater than one, with no more than six journals in any category, using 1999 ISI data. They included authors in the categories Business, Anthropology, Criminology & Penology, Education & Education Research, Political Science, Psychology, Sociology/Anthropology, and General Social Sciences. The Books in Print bibliographic tool was searched to identify monographs published by these authors, and any titles not already owned were purchased. All books in the study were available to patrons by Fall 2005. The researchers collected circulation data in Spring 2007, and used it to compare titles acquired by this method with titles selected by traditional means.Main Results – Overall, books selected by traditional methods circulated more than those selected by citation analysis, with differences significant at the .001 level. However, at the subject category level, there was no significant difference at the .05 level. Most books selected by the test method circulated one to two times.Conclusion – Citation analysis can be an effective method for building a relevant book collection, and may be especially effective for identifying works relevant to a discipline beyond local context.

  17. Monograph: Concluding Remarks

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2007-01-01

    standardization, conceptual issues, up gradation, conflict of interest, patient interest and systematization. Even items for individual preferences, choice or values are not neglected. Special mention must be made of items that specify disclosure of conflict of interest both in the Developer (including the organization that develops and the individuals involved in the guideline's formulation, as well as in the sponsor or funding source (and its role in developing and/or reporting the guideline.Recommendations of CPGs and CDR panels are conflicting. One considers effectiveness, the other cost-effectiveness. However, CPGs do not adhere to established methodological standards; critical information that would attest to validity is regularly absent; explicit criteria to grade scientific evidence that supports their recommendations is absent from 82% of guidelines; 87% are not in a position to report whether a systematic literature search was performed; 67% do not describe the type of professionals used in guidelines development; and there is marked variation in the quality of guidelines. Moreover, CPG guideline layers often are conflicted in their interests. The problem can be resolved to a large extent by taking a simple step: making CPG panelists go into cost effectiveness along with recommending Guidelines. What then happens is they have to consider not only effectiveness but also costs. Effectiveness can be fudged, cost cannot. Why? Because, what is the cost is well known. Therapies in Guidelines should be recommended and graded according to whether they are Most, Moderately or Least Cost Effective. For that CPGs will have to perform an economic analysis as well. This will meet with resistance for obvious reasons. Since guideline groups cannot be kept on the straight and narrow path and till we find fool proof ways of keeping them thus, we have no option but to stress that under no circumstances they can mislead, or get misled themselves, in the name of patient advocacy, to

  18. Effects of Hofmeister salt series on gluten network formation: Part I. Cation series.

    Science.gov (United States)

    Tuhumury, H C D; Small, D M; Day, L

    2016-12-01

    Different cationic salts were used to investigate the effects of the Hofmeister salt series on gluten network formation. The effects of cationic salts on wheat flour dough mixing properties, the rheological and the chemical properties of the gluten extracted from the dough with different respective salts, were investigated. The specific influence of different cationic salts on the gluten structure formation during dough mixing, compared to the sodium ion, were determined. The effects of different cations on dough and gluten of different flours mostly followed the Hofmeister series (NH4(+), K(+), Na(+), Mg(2+) and Ca(2+)). The impacts of cations on gluten structure and dough rheology at levels tested were relatively small. Therefore, the replacement of sodium from a technological standpoint is possible, particularly by monovalent cations such as NH4(+), or K(+). However the levels of replacement need to take into account sensory attributes of the cationic salts.

  19. South Asian Nomads--A Literature Review. CREATE Pathways to Access. Research Monograph No. 58

    Science.gov (United States)

    Sharma, Anita

    2011-01-01

    This review of literature on South Asian nomads is part of a series of monographs on educational access published by the Consortium for Research on Educational Access Transitions and Equity (CREATE). In the context of India, most recent work has focused on access to the education system for the poor. CREATE research in India has focused on …

  20. Force Limited Vibration Testing Monograph

    Science.gov (United States)

    Scharton, Terry D.

    1997-01-01

    The practice of limiting the shaker force in vibration tests was investigated at the NASA Jet Propulsion Laboratory (JPL) in 1990 after the mechanical failure of an aerospace component during a vibration test. Now force limiting is used in almost every major vibration test at JPL and in many vibration tests at NASA Goddard Space Flight Center (GSFC) and at many aerospace contractors. The basic ideas behind force limiting have been in the literature for several decades, but the piezo-electric force transducers necessary to conveniently implement force limiting have been available only in the last decade. In 1993, funding was obtained from the NASA headquarters Office of Chief Engineer to develop and document the technology needed to establish force limited vibration testing as a standard approach available to all NASA centers and aerospace contractors. This monograph is the final report on that effort and discusses the history, theory, and applications of the method in some detail.

  1. The Pharmacokinetics of Second-Generation Long-Acting Injectable Antipsychotics: Limitations of Monograph Values.

    Science.gov (United States)

    Lee, Lik Hang N; Choi, Charles; Collier, Abby C; Barr, Alasdair M; Honer, William G; Procyshyn, Ric M

    2015-12-01

    Product monographs (also known by terms such as Summary of Product Characteristics and Highlights of Prescribing Information, depending on the jurisdiction) provide essential information to ensure the safe and effective use of a drug. Medical practitioners often rely on these monographs for guidance on matters related to pharmacokinetics as well as indications, contraindications, clinical pharmacology, and adverse reactions. The clinical and scientific information found within these documents, forming the basis for decision making, are presumed to be derived from well-designed studies. The objective of this review is to examine the source and validity of the pharmacokinetic data used in establishing the half-lives and times to steady-state reported in the product monographs of second-generation long-acting injectable antipsychotics. Thus, we have critically evaluated the clinical trials from which the pharmacokinetic parameters listed in the product monographs were determined. In many cases, the pharmacokinetic information presented in product monographs is of limited use to clinicians wishing to optimize the effectiveness and tolerability of second-generation long-acting injectable antipsychotics. Under such circumstances, off-label prescribing practices may actually produce better clinical outcomes than if decisions were made based on the product monographs alone.

  2. Monograph on prospective developments in oceanology

    Science.gov (United States)

    Monin, A. S.

    1986-01-01

    Excerpts from a chapter of a monograph, Oceanology in the Year 2000, which has been prepared for publication at the USSR Academy of Sciences' Institute of Oceanology, is presented. The author of this chapter is A. S. Morin, corresponding member of the USSR Academy of Sciences and director of the oceanology institute. The monograph is said to be the collective work of a group of specialists. Monin views prospective developments of oceanology and oceanology related research and development, technology and expedition research.

  3. A Comprehensive List of Items to be Included on a Pediatric Drug Monograph.

    Science.gov (United States)

    Kelly, Lauren E; Ito, Shinya; Woods, David; Nunn, Anthony J; Taketomo, Carol; de Hoog, Matthijs; Offringa, Martin

    2017-01-01

    Children require special considerations for drug prescribing. Drug information summarized in a formulary containing drug monographs is essential for safe and effective prescribing. Currently, little is known about the information needs of those who prescribe and administer medicines to children. Our primary objective was to identify a list of important and relevant items to be included in a pediatric drug monograph. Following the establishment of an expert steering committee and an environmental scan of adult and pediatric formulary monograph items, 46 participants from 25 countries were invited to complete a 2-round Delphi survey. Questions regarding source of prescribing information and importance of items were recorded. An international consensus meeting to vote on and finalize the items list with the steering committee followed. Pediatric formularies are most commonly the first resource consulted for information on medication used in children by 31 Delphi participants. After the Delphi rounds, 116 items were identified to be included in a comprehensive pediatric drug monograph, including general information, adverse drug reactions, dosages, precautions, drug-drug interactions, formulation, and drug properties. Health care providers identified 116 monograph items as important for prescribing medicines for children by an international consensus-based process. This information will assist in setting standards for the creation of new pediatric drug monographs for international application and for those involved in pediatric formulary development.

  4. Preface to the third monograph

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2004-05-01

    Full Text Available Fashions come and go. Filmstars have their hey days and sink into oblivion. Technological gadgets become outdated sometimes even before they enter the market. Everyone wants the latest in TVs, computers, mobiles, cars, household appliances, industrial machinery, the works.We want to hear the latest news. Nobody prefers to read yesterday's newspaper today out of choice. We also want to read the latest edition of a book, and look up recent references and research work.We want the latest in treatments as well. The most recent is always considered an advancement over what was available earlier. Newer therapies, newer investigations, newer procedures.But, at the some time, we want to go to the senior consultant. And, given a choice, the older the better. Even elsewhere, we do not go to the junior most person to solve our problems if we can approach the senior man, and he is amenable. The recent graduate or postgraduate has the latest information, but it is the senior man who sits on the panel of examiners.We want the most recent in some cases, and the older and more experienced in others. Why should this happen? How should we handle our great need to update our knowledge on the latest, and yet not neglect the old and time-tested?This dilemma occurs in the research field as well, and psychiatry is no exception.What can be a healthy way of resolving this issue is the subject matter of this monograph.

  5. Deriving dynamic marketing effectiveness from econometric time series models

    NARCIS (Netherlands)

    C. Horváth (Csilla); Ph.H.B.F. Franses (Philip Hans)

    2003-01-01

    textabstractTo understand the relevance of marketing efforts, it has become standard practice to estimate the long-run and short-run effects of the marketing-mix, using, say, weekly scanner data. A common vehicle for this purpose is an econometric time series model. Issues that are addressed in the

  6. Analysis of Complex Intervention Effects in Time-Series Experiments.

    Science.gov (United States)

    Bower, Cathleen

    An iterative least squares procedure for analyzing the effect of various kinds of intervention in time-series data is described. There are numerous applications of this design in economics, education, and psychology, although until recently, no appropriate analysis techniques had been developed to deal with the model adequately. This paper…

  7. The Effect of the Gouin Series in Elementary English Teaching

    Institute of Scientific and Technical Information of China (English)

    李晶敏

    2015-01-01

    Although the Gouin Series originated in 19th century,it focuses on the sequenced structure of language teaching and the effect of the eyes,brain,ears,mouth in language learning. It also centered on the vitality of teaching.It advocates developing students’ communicative competence,so it plays a very important role in elementary English teaching.

  8. The Effect of the Gouin Series in Elementary English Teaching

    Institute of Scientific and Technical Information of China (English)

    李晶敏

    2015-01-01

    Although the Gouin Series originated in 19 th century,it focuses on the sequenced structure of language teaching and the effect of the eyes,brain,ears,mouth in language learning.It also centered on the vitality of teaching.It advocates developing students’ communicative competence,so it plays a very important role in elementary English teaching.

  9. Effects of Hofmeister salt series on gluten network formation: Part II. Anion series.

    Science.gov (United States)

    Tuhumury, H C D; Small, D M; Day, L

    2016-12-01

    Different anion salts from the Hofmeister series were used to investigate their effects on gluten network formation. The effects of these anion salts on the mixing properties of the dough and the rheological and chemical properties of gluten samples extracted from the dough with these respective salts were compared. The aim of this work was to determine how different anion salts influence the formation of the gluten structure during dough mixing. It was found that the Hofmeister anion salts affected the gluten network formation by interacting directly with specific amino acid residues that resulted in changes in gluten protein composition, specifically the percentage of the unextractable polymeric protein fractions (%UPP). These changes consequently led to remarkable differences in the mixing profiles and microstructural features of the dough, small deformation rheological properties of the gluten and a strain hardening behaviour of both dough and gluten samples.

  10. Preface to the seventh monograph

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2005-01-01

    Full Text Available Like all good neighbours, competing schools of psychiatry claw at each other. Like all good samaritans, some people try to play arbiters and douse the fires. The tradition of fights and retaliation is not new to psy­chiatry, neither is it unique to the branch. Competing schools of thought exist almost everywhere. And it is tempting to say that the more intellec­tually robust a field, the greater the controversies and fights in it.In fact if intellectuals were to come together and not voice differences, either they are not intellectuals, or they have no opinions. (Or they may be simply scared, or silenced for other reasons.Ofcourse we must note that while in other fields of thought there can be controversies, there is one essential difference. They may not be dealing with patients and their lives. And to that the corollary is that psychiatric controversies should not be carried out at the expense of patient welfare.Having said that, let us also note that when there are fights, arbiters become very active. As do advocates, of one or the other approach.In this monograph we have tried to act the arbiters. Maybe because it is appropriate. Maybe also because that's the only thing we can do (and may be do well: atleast that's what we would love to believe.Why not advocates ? Well, for one, there are so many already. For another, we run the risk of doing a poor job of it.Not that we have necessarily done a good job of being arbiters.

  11. Bibliometrics of NIHR HTA monographs and their related journal articles.

    Science.gov (United States)

    Royle, Pamela; Waugh, Norman

    2015-02-18

    A bibliometric analysis of the UK National Institute for Health Research (NIHR) Health Technology Assessment (HTA) monographs and their related journal articles by: (1) exploring the differences in citations to the HTA monographs in Google Scholar (GS), Scopus and Web of Science (WoS), and (2) comparing Scopus citations to the monographs with their related journal articles. A study of 111 HTA monographs published in 2010 and 2011, and their external journal articles. Citations to the monographs in GS, Scopus and WoS, and to their external journal articles in Scopus. The number of citations varied among the three databases, with GS having the highest and WoS the lowest; however, the citation-based rankings among the databases were highly correlated. Overall, 56% of monographs had a related publication, with the highest proportion for primary research (76%) and lowest for evidence syntheses (43%). There was a large variation in how the monographs were cited, compared to journal articles, resulting in more frequent problems, with unlinked citations in Scopus and WoS. When comparing differences in the number of citations between monograph publications with their related journal articles from the same project, we found that monographs received more citations than their journal articles for evidence syntheses and methodology projects; by contrast, journal articles related to primary research monographs were more highly cited than their monograph. The numbers of citations to the HTA monographs differed considerably between the databases, but were highly correlated. When a HTA monograph had a journal article from the same study, there were more citations to the journal article for primary research, but more to the monographs for evidence syntheses. Citations to the related journal articles were more reliably recorded than citations to the HTA monographs. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please

  12. An Overview of Dental Radiology. NCHCT Monograph Series.

    Science.gov (United States)

    Manny, Edward F.; And Others

    This overview of dental radiology contains sections on demographics, equipment, dental radiology quality assurance, efficacy, dental radiology education curricula, professional organizations' guidelines for training and use, and state activities. In section 1 dental personnel, population of dental personnel, employment and earning prospects,…

  13. Biotechnology, Genetic Engineering and Society. Monograph Series: III.

    Science.gov (United States)

    Kieffer, George H.

    New techniques have expanded the field of biotechnology and awarded scientists an unprecedented degree of control over the genetic constitutions of living things. The knowledge of DNA science is the basis for this burgeoning industry which may be a major force in human existence. Just as it is possible to move genetic material from one organism to…

  14. The Chemistry of Vat Dyes. Palette of Color Monograph Series.

    Science.gov (United States)

    Epp, Dianne N.

    From prehistoric times people have been fascinated with color; from cave paintings to the latest computers, color has been a constant companion. Textiles are made more beautiful by the alteration or application of colorants. This teaching resource investigates vat dyes, a colorant class which includes the oldest dyes known as well as important…

  15. The Chemistry of Natural Dyes. Palette of Color Monograph Series.

    Science.gov (United States)

    Epp, Dianne N.

    From prehistoric times people have been fascinated with color; from cave paintings to the latest computers, color has been a constant companion. Textiles and craft items are made more beautiful by the alteration or application of colorants. This teaching resource investigates dyes obtained from natural sources, such as plants and animals. These…

  16. The Chemistry of Natural Dyes. Palette of Color Monograph Series.

    Science.gov (United States)

    Epp, Dianne N.

    From prehistoric times people have been fascinated with color; from cave paintings to the latest computers, color has been a constant companion. Textiles and craft items are made more beautiful by the alteration or application of colorants. This teaching resource investigates dyes obtained from natural sources, such as plants and animals. These…

  17. Bureau of Mines War Gas Investigations (WGI) Monographs (Old Series)

    Science.gov (United States)

    2015-01-01

    sulfide from Ethylene chloro- iodide: Helferich & Reid 5 394. Report on G-34: Conant 9 395. Report on the chlorination of Methyl sulfide...2 Preparation 2 3 Possible use of Ethylene dihalides 5 4 Nature of Diethylene disulfide 10 5 Possible use of Ethyl sulfide 13 6 German...method of manufacture 13 7 Manufacture A. Chlorhydrin method 15 1. Ethylene 16 2. Ethylene Chlorhydrin 25 3. Thiodiglycol 45

  18. Values, Inquiry, and Education. CSE Monograph Series in Evaluation, 9.

    Science.gov (United States)

    Gideonse, Hendrik, Ed.; And Others

    This edited volume contains 16 social science-related educational research articles based on papers presented at the 1979 annual meeting of the American Educational Research Association (AERA). The articles and associated commentary are organized according to six symposia held at the meeting--anthropology, evaluation, history, political science,…

  19. State Defense Force Monograph Series. Fall 2007, Special Units

    Science.gov (United States)

    2007-01-01

    authors and the visual panorama of artists and film makers. Those World War Two soldiers for whom “taps” has not yet been sounded may still remember the...is a reenactor and living historian, with an emphasis on mounted cavalry, formed and commanded many reenactment units, trained numerous soldiers in

  20. Demography and Educational Planning. Monograph Series No. 7.

    Science.gov (United States)

    Macleod, Betty, Ed.

    The OISE Educational Planning Department launched a research program to determine the current patterns of fertility and migration of the Ontario population, with a view to subsequent investigations into the interrelationships between population growth and shift and education. Demographers and educators engaged in demographic research related to…

  1. Methadone Diversion: Experiences and Issues. Services Research Monograph Series.

    Science.gov (United States)

    Inciardi, James A.

    This report is a description of the phenomenon of methadone diversion as it exists now and places it in the context of prior research in this area. The intent here is to clarify issues around methadone diversion and to provide guidance to treatment administrators and program planners regarding efforts they can initiate to monitor this significant…

  2. Modeling Periodic Impulsive Effects on Online TV Series Diffusion.

    Science.gov (United States)

    Fu, Peihua; Zhu, Anding; Fang, Qiwen; Wang, Xi

    Online broadcasting substantially affects the production, distribution, and profit of TV series. In addition, online word-of-mouth significantly affects the diffusion of TV series. Because on-demand streaming rates are the most important factor that influences the earnings of online video suppliers, streaming statistics and forecasting trends are valuable. In this paper, we investigate the effects of periodic impulsive stimulation and pre-launch promotion on on-demand streaming dynamics. We consider imbalanced audience feverish distribution using an impulsive susceptible-infected-removed(SIR)-like model. In addition, we perform a correlation analysis of online buzz volume based on Baidu Index data. We propose a PI-SIR model to evolve audience dynamics and translate them into on-demand streaming fluctuations, which can be observed and comprehended by online video suppliers. Six South Korean TV series datasets are used to test the model. We develop a coarse-to-fine two-step fitting scheme to estimate the model parameters, first by fitting inter-period accumulation and then by fitting inner-period feverish distribution. We find that audience members display similar viewing habits. That is, they seek new episodes every update day but fade away. This outcome means that impulsive intensity plays a crucial role in on-demand streaming diffusion. In addition, the initial audience size and online buzz are significant factors. On-demand streaming fluctuation is highly correlated with online buzz fluctuation. To stimulate audience attention and interpersonal diffusion, it is worthwhile to invest in promotion near update days. Strong pre-launch promotion is also a good marketing tool to improve overall performance. It is not advisable for online video providers to promote several popular TV series on the same update day. Inter-period accumulation is a feasible forecasting tool to predict the future trend of the on-demand streaming amount. The buzz in public social communities

  3. Removing atmosphere loading effect from GPS time series

    Science.gov (United States)

    Tiampo, K. F.; Samadi Alinia, H.; Samsonov, S. V.; Gonzalez, P. J.

    2015-12-01

    The GPS time series of site position are contaminated by various sources of noise; in particular, the ionospheric and tropospheric path delays are significant [Gray et al., 2000; Meyer et al., 2006]. The GPS path delay in the ionosphere is largely dependent on the wave frequency whereas the delay in troposphere is dependent on the length of the travel path and therefore site elevation. Various approaches available for compensating ionosphere path delay cannot be used for removal of the tropospheric component. Quantifying the tropospheric delay plays an important role for determination of the vertical GPS component precision, as tropospheric parameters over a large distance have very little correlation with each other. Several methods have been proposed for tropospheric signal elimination from GPS vertical time series. Here we utilize surface temperature fluctuations and seasonal variations in water vapour and air pressure data for various spatial and temporal profiles in order to more accurately remove the atmospheric path delay [Samsonov et al., 2014]. In this paper, we model the atmospheric path delay of vertical position time series by analyzing the signal in the frequency domain and study its dependency on topography in eastern Ontario for the time period from January 2008 to December 2012. Systematic dependency of amplitude of atmospheric path delay as a function of height and its temporal variations based on the development of a new, physics-based model relating tropospheric/atmospheric effects with topography and can help in determining the most accurate GPS position.The GPS time series of site position are contaminated by various sources of noise; in particular, the ionospheric and tropospheric path delays are significant [Gray et al., 2000; Meyer et al., 2006]. The GPS path delay in the ionosphere is largely dependent on the wave frequency whereas the delay in troposphere is dependent on the length of the travel path and therefore site elevation. Various

  4. Man-made mineral (vitreous) fibres: evaluations of cancer hazards by the IARC Monographs Programme.

    Science.gov (United States)

    Baan, Robert A; Grosse, Yann

    2004-09-03

    Man-made vitreous (glass-like) fibres are non-crystalline, fibrous inorganic substances (silicates) made primarily from rock, slag, glass or other processed minerals. These materials, also called man-made mineral fibres, include glass fibres (used in glass wool and continuous glass filament), rock or stone wool, slag wool and refractory ceramic fibres. They are widely used for thermal and acoustical insulation and to a lesser extent for other purposes. These products are potentially hazardous to human health because they release airborne respirable fibres during their production, use and removal. Man-made mineral fibres and man-made vitreous fibres have been the subject of reviews by IARC Monographs Working Groups in 1987 and 2001, respectively, which resulted in evaluations of the carcinogenic hazard to humans from exposure to these materials. These reviews and evaluations have been published as Volumes 43 and 81 of the IARC Monographs series [IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 43, Man-made Mineral Fibres and Radon (1988); IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 81, Man-made Vitreous Fibres (2002)]. The re-evaluation in 2001 was undertaken because there have been substantial improvements in the quality of the epidemiological information available on the carcinogenicity to humans of glass fibres, continuous glass filament and rock/slag wool. The new evaluations have addressed the limitations of earlier cohort studies, particularly concerning the lack of adjustment with respect to concomitant risk factors such as smoking and other sources of occupational exposure. In addition, the evaluation of the evidence for carcinogenicity of glass fibres to experimental animals has been refined, by making a distinction between insulation glass wool and special-purpose glass fibres. The results of the evaluations in 1987 and 2001 are thus different in several aspects. In this paper, the reviews and evaluations

  5. Clinical effectiveness of electroacupuncture in meralgia paraesthetica: a case series.

    Science.gov (United States)

    Alexander, Rosemary E

    2013-12-01

    Meralgia paraesthetica is a fairly common condition resulting from entrapment of the lateral femoral cutaneous nerve. I have found that acupuncture produces a rapid improvement, sometimes effecting a cure, after only one or two treatments. I therefore invited referrals in order to collect a case series. A series of 10 patients, which included two who had refused surgery, but excluded those with significant lumbar spine problems, were treated. Visual Analogue Scale pain scores and analgesic intake were recorded weekly, starting before treatment. Four patients were receiving high doses of analgesics and the average period of symptoms was 3-4 years. Acupuncture points used were BL25, GB30, GB34, GB31, GB32, Huatuojiaji and ah shi points of the buttock and thigh, up to a depth of 7.5 cm. Electroacupuncture was normally given from the second treatment. Without exception, patients were specifically tender over GB31 before they started treatment. Most were also tender over the upper lumbar spine. An average of four to five sessions of acupuncture was given. The pain scores for all 10 patients improved by at least 50%, including that of a patient with a 20-year history. At follow-up (varying from 3 to 36 months), improvement was nearly 100%. Most patients were able to stop their analgesics. Meralgia paraesthetica appears to respond rapidly to electroacupuncture. A significant trigger point at GB31 was universally present, which may aid diagnosis, although the reason for this is unclear. Further controlled studies are justified.

  6. Financial time series analysis based on effective phase transfer entropy

    Science.gov (United States)

    Yang, Pengbo; Shang, Pengjian; Lin, Aijing

    2017-02-01

    Transfer entropy is a powerful technique which is able to quantify the impact of one dynamic system on another system. In this paper, we propose the effective phase transfer entropy method based on the transfer entropy method. We use simulated data to test the performance of this method, and the experimental results confirm that the proposed approach is capable of detecting the information transfer between the systems. We also explore the relationship between effective phase transfer entropy and some variables, such as data size, coupling strength and noise. The effective phase transfer entropy is positively correlated with the data size and the coupling strength. Even in the presence of a large amount of noise, it can detect the information transfer between systems, and it is very robust to noise. Moreover, this measure is indeed able to accurately estimate the information flow between systems compared with phase transfer entropy. In order to reflect the application of this method in practice, we apply this method to financial time series and gain new insight into the interactions between systems. It is demonstrated that the effective phase transfer entropy can be used to detect some economic fluctuations in the financial market. To summarize, the effective phase transfer entropy method is a very efficient tool to estimate the information flow between systems.

  7. Time series trends of the safety effects of pavement resurfacing.

    Science.gov (United States)

    Park, Juneyoung; Abdel-Aty, Mohamed; Wang, Jung-Han

    2017-04-01

    This study evaluated the safety performance of pavement resurfacing projects on urban arterials in Florida using the observational before and after approaches. The safety effects of pavement resurfacing were quantified in the crash modification factors (CMFs) and estimated based on different ranges of heavy vehicle traffic volume and time changes for different severity levels. In order to evaluate the variation of CMFs over time, crash modification functions (CMFunctions) were developed using nonlinear regression and time series models. The results showed that pavement resurfacing projects decrease crash frequency and are found to be more safety effective to reduce severe crashes in general. Moreover, the results of the general relationship between the safety effects and time changes indicated that the CMFs increase over time after the resurfacing treatment. It was also found that pavement resurfacing projects for the urban roadways with higher heavy vehicle volume rate are more safety effective than the roadways with lower heavy vehicle volume rate. Based on the exploration and comparison of the developed CMFucntions, the seasonal autoregressive integrated moving average (SARIMA) and exponential functional form of the nonlinear regression models can be utilized to identify the trend of CMFs over time. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Creative Drama as a Resource, K-12. Language Arts Monograph.

    Science.gov (United States)

    Sharpham, John R.

    Defining creative drama as a teaching process that uses the inherent ability of each person to explore ideas, behavior patterns, and human relationships, this monograph is designed to help teachers create a working environment within which this process can be most productive. Various sections of the monograph provide information about how creative…

  9. [Leon Daraszkiewicz and his monograph on hebephrenia].

    Science.gov (United States)

    Marcinowski, Filip

    2012-01-01

    Leon Daraszkiewicz (1866-1931) was a Polish psychiatrist, a pupil and co-worker of E. Kraepelin and V. Tsiz on the University of Dorpat (now Tartu, Estonia), the author of highly regarded monograph on hebephrenia (1891). In his work on the basis of over 20 case histories, he described a natural history of hebephrenia and his own views on its aetiology and prognosis. Hebephrenia as described by Daraszkiewicz, served as a clinical model for the Kraepelinian concept of dementia praecox. In the article, the life and career of Daraszkiewicz is covered, with particular emphasis on the role of his doctoral dissertation on hebephrenia in the history of the concept of schizophrenia.

  10. Monograph for using paleoflood data in Water Resources Applications

    Science.gov (United States)

    Swain, R.E.; Jarrett, R.D.

    2004-01-01

    The Environmental and Water Resources Institute (EWRI) Technical Committee on Surface Water Hydrology is sponsoring a Task Committee on Paleoflood Hydrology to prepare a monograph entitled, "Use of Paleoflood and Historical Data in Water Resources Applications." This paper introduces the subject of paleoflood hydrology and discusses the topics, which are expected to be included in the monograph. The procedure for preparing and reviewing the monograph will also be discussed. The paleoflood hydrology monograph will include a discussion of types of hydrologic and paleoflood data, paleostage indicators, flood chronology, modeling methods, interpretation issues, water resources applications and case studies, and research needs. Paleoflood data collection and analysis techniques will be presented, and various applications in water-resources investigations will be provided. An overview of several flood frequency analysis approaches, which consider historical and paleoflood data along with systematic streamflow records, will be presented. The monograph is scheduled for completion and publication in 2001. Copyright ASCE 2004.

  11. Time series momentum and contrarian effects in the Chinese stock market

    Science.gov (United States)

    Shi, Huai-Long; Zhou, Wei-Xing

    2017-10-01

    This paper concentrates on the time series momentum or contrarian effects in the Chinese stock market. We evaluate the performance of the time series momentum strategy applied to major stock indices in mainland China and explore the relation between the performance of time series momentum strategies and some firm-specific characteristics. Our findings indicate that there is a time series momentum effect in the short run and a contrarian effect in the long run in the Chinese stock market. The performances of the time series momentum and contrarian strategies are highly dependent on the look-back and holding periods and firm-specific characteristics.

  12. Time-series intervention analysis of pedestrian countdown timer effects.

    Science.gov (United States)

    Huitema, Bradley E; Van Houten, Ron; Manal, Hana

    2014-11-01

    Pedestrians account for 40-50% of traffic fatalities in large cities. Several previous studies based on relatively small samples have concluded that Pedestrian Countdown Timers (PCT) may reduce pedestrian crashes at signalized intersections, but other studies report no reduction. The purposes of the present article are to (1) describe a new methodology to evaluate the effectiveness of introducing PCT signals and (2) to present results of applying this methodology to pedestrian crash data collected in a large study carried out in Detroit, Michigan. The study design incorporated within-unit as well as between-unit components. The main focus was on dynamic effects that occurred within the PCT unit of 362 treated sites during the 120 months of the study. An interrupted time-series analysis was developed to evaluate whether change in crash frequency depended upon of the degree to which the countdown timers penetrated the treatment unit. The between-unit component involved comparisons between the treatment unit and a control unit. The overall conclusion is that the introduction of PCT signals in Detroit reduced pedestrian crashes to approximately one-third of the preintervention level. The evidence for this reductionis strong and the change over time was shown to be a function of the extent to which the timers were introduced during the intervention period. There was no general drop-off in crash frequency throughout the baseline interval of over five years; only when the PCT signals were introduced in large numbers was consistent and convincing crash reduction observed. Correspondingly, there was little evidence of change in the control unit. Copyright © 2014. Published by Elsevier Ltd.

  13. Questions That This Monograph Raises

    Directory of Open Access Journals (Sweden)

    Editors

    2007-01-01

    Full Text Available What is the ideal combination of increased investment in biomedical research by sponsors with least conflict of interest in researchers?What should interested parties do to refurbish pharma's image?Is a voluntary moratorium on pharma spending practically possible?How to resolve the basic schism between profit driven industry and welfare driven profession of medicine?How can CPGs be salvaged from ulterior influence?Can guidelines on guidelines help?Is cost-effectiveness of CPGs a practical solution?Is it possible to grade therapies as Most, Moderate and Least Cost Effective?How can Disease specific Foundations be salvaged from sponsor's influence?How can Journals ensure scientific integrity of conflicted authors and nullify untoward influence of sponsors?Are reports like the Task Force on individual and institutional conflicts of interest of the AAMC followed more in their breach?Are the revised ICMJE guidelines adequate to stub conflicted research?Editorials make pious announcements. Do they really influence what researchers do?How do we protect the interests of human research subjects?Do Best Practice Guidelines and Good Publication Practices really help?Marketability is the name of the game, not usefulness. How do we ensure the latter, even as the former is forwarded?How can we ensure effective traditional therapies remain in use even as new ones are forwarded?How do we ensure non-pharmacological therapies are also forwarded?How can the legitimate thrust of biological psychiatry be encouraged while also forwarding non-pharmacological approaches in psychiatry?What can be done so pharma just cannot consider questionable means as an attractive alternative?How do we expedite scientific self-correction while causing least harm to patients and research subjects?

  14. Ramanujan summation of divergent series

    CERN Document Server

    Candelpergher, Bernard

    2017-01-01

    The aim of this monograph is to give a detailed exposition of the summation method that Ramanujan uses in Chapter VI of his second Notebook. This method, presented by Ramanujan as an application of the Euler-MacLaurin formula, is here extended using a difference equation in a space of analytic functions. This provides simple proofs of theorems on the summation of some divergent series. Several examples and applications are given. For numerical evaluation, a formula in terms of convergent series is provided by the use of Newton interpolation. The relation with other summation processes such as those of Borel and Euler is also studied. Finally, in the last chapter, a purely algebraic theory is developed that unifies all these summation processes. This monograph is aimed at graduate students and researchers who have a basic knowledge of analytic function theory.

  15. MSM 2010 Theme Monograph Psychopharmacology Today

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2010-01-01

    Full Text Available This theme monograph is called Psychopharmacology Today. It has some notable contributions on issues in psychopharmacology.MSM 2010 is dedicated to the fond memory of Dr V.N. Bagadia, who headed our Hon International Editorial Advisory Board. See Dedication, " Dr Bagadia, Sir, is no more"(p3.Thomas L. Schwartz, M.D. Associate Professor of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA writes an editorial on, "Psychopharmacology today: where are we and where do we go from here?"(p6.Ajai R. Singh, MD. Editor, Mens Sana Monographs, writes the second editorial on, "Modern medicine: towards prevention, cure, well-being and longevity"(p17.Sannidhya Varma, Himanshu Sareen and J.K. Trivedi from CSM Medical University, Lucknow, India, write on, "The Geriatric Population and Psychiatric Medication"(p30.Amresh Shrivastava from The University of Western Ontario, Department of Psychiatry and Megan E. Johnston from University of Toronto, Department of Psychology, write on, "Weight Gain in Psychiatric Treatment: Risks, Implications, and Strategies for Prevention and Management"(p53.Avinash De Sousa, M.D. Consultant Psychiatrist& Psychotherapist, Mumbai, writes on, "The Pharmacotherapy of Alcohol Dependence: A State of the Art Review"(p69. Late B. M. Tripathi, M.D. Professor, Department of Psychiatry and National Drug Dependence and Treatment Center, All India Institute of Medical Sciences, and Pradipta Majumder, MBBS, Resident, Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, write on, "Lactating Mother and Psychotropic Drugs"(p83.K.S. Latha PhD. Associate Professor, Department of Psychiatry, KMC Hospital, Manipal University, writes on, "The Noncompliant Patient in Psychiatry: The Case For and Against Covert/Surreptitious Medication"(p96. Neha Khetrapal, [M.A. Cognitive Science], Centre of Excellence "Cognitive Interaction Technology" (CITEC And Faculty of Psychology& Sport Sciences, University of Bielefeld, Germany

  16. NTP-CERHR monograph on Soy Infant Formula.

    Science.gov (United States)

    2010-09-01

    Soy infant formula contains soy protein isolates and is fed to infants as a supplement to or replacement for human milk or cow milk. Soy protein isolates contains estrogenic isoflavones ("phytoestrogens") that occur naturally in some legumes, especially soybeans. Phytoestrogens are non-steroidal, estrogenic compounds. In plants, nearly all phytoestrogens are bound to sugar molecules and these phytoestrogen-sugar complexes are not generally considered hormonally active. Phytoestrogens are found in many food products in addition to soy infant formula, especially soy-based foods such as tofu, soy milk, and in some over-the-counter dietary supplements. Soy infant formula was selected for evaluation by the National Toxicology Program (NTP) because of the: (1)availability of large number of developmental toxicity studies in laboratory animals exposed to the isoflavones found in soy infant formula (namely, genistein) or other soy products, as well as a number of studies on human infants fed soy infant formula, (2)the availability of information on exposures in infants fed soy infant formula, and (3)public concern for effects on infant or child development. The NTP evaluation was conducted through its Center for the Evaluation of Risks to Human Reproduction (CERHR) and completed in September 2010. The results of this soy infant formula evaluation are published in an NTP Monograph. This document contains the NTP Brief on Soy Infant Formula, which presents NTP's opinion on the potential for exposure to soy infant formula to cause adverse developmental effects in humans. The NTP Monograph also contains an expert panel report prepared to assist the NTP in reaching conclusions on soy infant formula. The NTP concluded there is minimal concern for adverse effects on development in infants who consume soy infant formula. This level of concern represents a "2" on the five-level scale of concern used by the NTP that ranges from negligible concern ("1") to serious concern ("5"). This

  17. Temperature effects on dog hindpaw series and parallel vascular circuits

    National Research Council Canada - National Science Library

    Baker, C H; Davis, D L; Lindsey, B G; Sutton, E T

    1983-01-01

    The effect of environmental temperature (skin surface) on distribution of blood flow between the parallel vascular circuits has been assessed in vascularly and neurally isolated hindpaws perfused at constant pressure...

  18. Just entertainment: effects of TV series about intrigue on young adults.

    Science.gov (United States)

    Wang, Fei; Lin, Shengdong; Ke, Xue

    2015-01-01

    The potential harmful effects of media violence have been studied systematically and extensively. However, very little attention has been devoted to the intrigue and struggles between people depicted in the mass media. A longitudinal randomized experimental group-control group, pretest-posttest design study was conducted to examine the potential effects of this type of TV series on young adults. A typical and popular TV series was select as a stimulus. By scrutinizing the outline of this TV series and inspired by studies of the effects of media violence, one behavioral observation and five scales were adopted as dependent measures. The study did not find any effect of the intrigue TV series on any of the six dependent variables. Finally, possible interference variables or moderators were discussed.

  19. Just Entertainment: Effects of TV series about Intrigue on Young Adults

    Directory of Open Access Journals (Sweden)

    Fei eWANG

    2015-04-01

    Full Text Available The potential harmful effects of media violence have been studied systematically and extensively. However, very little attention has been devoted to the intrigue and struggles between people depicted in the mass media. A longitudinal randomized experimental group-control group, pretest–posttest design study was conducted to examine the potential effects of this type of TV series on young adults. A typical and popular TV series was select as a stimulus. By scrutinizing the outline of this TV series and inspired by studies of the effects of media violence, one behavioral observation and five scales were adopted as dependent measures. The study did not find any effect of the intrigue TV series on any of the six dependent variables. Finally, possible interference variables or moderators were discussed.

  20. Cost-Effective School Alarm Systems. Security Topics Series.

    Science.gov (United States)

    Kaufer, Steve

    This document outlines considerations in the selection of a cost-effective school-alarm system. Steps in the planning process include: conducting a district needs assessment; gathering input from all staff levels; consulting technical expertise; and selecting a security system that can be integrated with other site needs. It further describes the…

  1. Effective Pedagogy in Social Sciences. Educational Practices Series-23

    Science.gov (United States)

    Sinnema, Claire; Aitken, Graeme

    2012-01-01

    This booklet is a synthesis of research on social sciences teaching that has been shown to have a positive effect on a range of desirable student outcomes: cognitive, skills, participatory and affective outcomes. Education in the social sciences plays an important role in developing students' sense of identity and influencing the ways in which…

  2. Effective Pedagogy in Social Sciences. Educational Practices Series-23

    Science.gov (United States)

    Sinnema, Claire; Aitken, Graeme

    2012-01-01

    This booklet is a synthesis of research on social sciences teaching that has been shown to have a positive effect on a range of desirable student outcomes: cognitive, skills, participatory and affective outcomes. Education in the social sciences plays an important role in developing students' sense of identity and influencing the ways in which…

  3. Facing the Risks of the "Mozart Effect." Grand Masters Series.

    Science.gov (United States)

    Reimer, Bennett

    1999-01-01

    Explores the argument introduced by the "Mozart Effect" research: that music's positive influence on spatial-temporal reasoning should be the purpose for music education. Considers the implications by reshaping the National Standards for Music Education to fulfill the spatial-temporal rationale. Suggests how to reconcile musical and…

  4. Facing the Risks of the "Mozart Effect." Grand Masters Series.

    Science.gov (United States)

    Reimer, Bennett

    1999-01-01

    Explores the argument introduced by the "Mozart Effect" research: that music's positive influence on spatial-temporal reasoning should be the purpose for music education. Considers the implications by reshaping the National Standards for Music Education to fulfill the spatial-temporal rationale. Suggests how to reconcile musical and…

  5. Prediction analysis of long-term memory effect for calamity gray series

    Institute of Scientific and Technical Information of China (English)

    CHEN; Zhaonan(CHEN; Chaonan); LI; Zongyang(LEE; Tzongye

    2004-01-01

    It is adequate to use the gray theory for modeling and forecasting short-term calamity series. The forecast of calamity gray series is equivalent to predicting an extraordinary event in nature. In order to look for the regularity, the calamity date series, created from the threshold for a fixed time-interval series, are studied. In this paper, the Hurst exponent is applied to defining the long-term memory effect of the simulated calamity series, and is tested for the feasibility of using it as pre-requisite information before the gray modeling and forecasting. Based on the fractional Brownian motion (fBm) model, the time series with a definite length or quantity of data are derived assuming that various kinds of memory effect exist. Different threshold values are defined to yield or to analogize the calamity date series that are required in the prediction of the gray calamity events. After case study, both of the simulated and real seismic data show that the Hurst exponents are greater than 0.5 and, therefore, indicate that the long-term memory effect exists. The correlation between the Hurst exponent and the gray modeling parameter, a, provides criteria for the classification of the forecast.

  6. A monograph of Otidea (Pyronemataceae, Pezizomycetes).

    Science.gov (United States)

    Olariaga, I; Van Vooren, N; Carbone, M; Hansen, K

    2015-12-01

    The easily recognised genus Otidea is subjected to numerous problems in species identification. A number of old names have undergone various interpretations, materials from different continents have not been compared and misidentifications occur commonly. In this context, Otidea is monographed, based on our multiple gene phylogenies assessing species boundaries and comparative morphological characters (see Hansen & Olariaga 2015). All names combined in or synonymised with Otidea are dealt with. Thirty-three species are treated, with full descriptions and colour illustrations provided for 25 of these. Five new species are described, viz. O. borealis, O. brunneoparva, O. oregonensis, O. pseudoleporina and O. subformicarum. Otidea cantharella var. minor and O. onotica var. brevispora are elevated to species rank. Otideopsis kaushalii is combined in the genus Otidea. A key to the species of Otidea is given. An LSU dataset containing 167 sequences (with 44 newly generated in this study) is analysed to place collections and determine whether the named Otidea sequences in GenBank were identified correctly. Fourty-nine new ITS sequences were generated in this study. The ITS region is too variable to align across Otidea, but had low intraspecific variation and it aided in species identifications. Thirty type collections were studied, and ITS and LSU sequences are provided for 12 of these. A neotype is designated for O. cantharella and epitypes for O. concinna, O. leporina and O. onotica, along with several lectotypifications. The apothecial colour and shape, and spore characters are important for species identification. We conclude that to distinguish closely related or morphologically similar species, a combination of additional features are needed, i.e. the shape of the paraphyses, ectal excipulum structure, types of ectal excipulum resinous exudates and their reactions in Melzer's reagent and KOH, tomentum and basal mycelium colours and exudates. The KOH reaction of

  7. Formation Mechanism of the Accumulative Magnification Effect in a Financial Time Series

    Institute of Scientific and Technical Information of China (English)

    DUAN Wen-Qi

    2012-01-01

    Structural information contained in financial time series can be magnified effectively by constructing the accumulative return.In order to make the magnification effects of different financial time series comparative,we first propose a standard method to characterize the strength of the accumulative magnification effect.Then,we employ decomposed-randomized technology to uncover the formation mechanism of the accumulative magnification effect.Our results show that (1) the standard deviation pattern is determined by volatility dependence,(2) the Hurst exponent pattern is induced by sign dependence,(3) an approximate entropy pattern is caused by the combined effect of sign dependence and volatility dependence.

  8. 75 FR 30838 - Drometrizole Trisiloxane Eligibility for Potential Inclusion in Sunscreen Monograph; Over-the...

    Science.gov (United States)

    2010-06-02

    ... Eligibility for Potential Inclusion in Sunscreen Monograph; Over-the-Counter Sunscreen Drug Products for Human... monograph. We reviewed a time and extent application (TEA) for drometrizole trisiloxane and determined that it is eligible to be considered for inclusion in our OTC drug monograph system. We will evaluate the...

  9. 78 FR 4419 - Draft Report on Carcinogens Monographs for 1-Bromopropane and Cumene; Availability of Documents...

    Science.gov (United States)

    2013-01-22

    ... HUMAN SERVICES National Institutes of Health Draft Report on Carcinogens Monographs for 1-Bromopropane... meeting of the Draft Report on Carcinogens (RoC) Monographs for 1-Bromopropane and Cumene. These documents....m. until adjournment, approximately 2:00 p.m. EDT. Document Availability: Draft monographs will...

  10. Adjusting for calendar effects of real retail trade turnover time series

    Directory of Open Access Journals (Sweden)

    Josip Arnerić

    2015-10-01

    Full Text Available Fluctuations in economic activity are often influenced by calendar-based various factors. Such factors are non-working (non-trading days, leap years, public holidays and the like. Most economic series are observed on a monthly or quarterly basis, but months (aggregated into quarters are not comparable due to the different number of working and non-working days (different number of Mondays, Tuesdays, etc.. If the calendar effects are not properly adjusted, the identification of the ARIMA model for a given time series might not be correct, and the quality of seasonal adjustment is poor. An inappropriate calendar adjustment can generate false signals and negatively affect interpretation of adjusted data, which is particularly important for time series of retail sales and industrial productions. However, there is no general or unique procedure for correcting calendar effects in a pre-adjustment process of a time series. Therefore, this paper compares various regression models using alternative explanatory variables that take into account calendar effects and applied them to the time series of real retail trade turnover (RRT in Croatia (monthly data observed from January 2001 to December 2013. The paper seeks to define a new explanatory variable (a regressor with time varying ratio between the average number of working days and the average number of non-working days providing the most accurate correction of a RRT time series influenced by calendar effects. In addition, the assumption is that Saturdays and Sundays are working days of the week.

  11. The monographic sociology from the perspective of American critical ethnography

    Directory of Open Access Journals (Sweden)

    Șerban Văetiși

    2013-11-01

    Full Text Available The paper attempts to reconsider some theoretical and methodological principles practiced by the Bucharest School of Sociology by invoking some concepts put forward by the so called Critical Ethnography. It considers three major ideas of the Monographic Sociology, that can be also found as theoretical assumptions of the postmodern critical ethnographic theory, in an interesting parallel that can be, thus, reconstructed and further suggested as useful paradigm within current approaches in social sciences and policies: interdisciplinarity, activism and criticism. The paper concludes on the contribution that the Monographic School may have to the current social theory, research and policy developed today in Romania.

  12. Stochastic model stationarization by eliminating the periodic term and its effect on time series prediction

    Science.gov (United States)

    Moeeni, Hamid; Bonakdari, Hossein; Fatemi, Seyed Ehsan

    2017-04-01

    Because time series stationarization has a key role in stochastic modeling results, three methods are analyzed in this study. The methods are seasonal differencing, seasonal standardization and spectral analysis to eliminate the periodic effect on time series stationarity. First, six time series including 4 streamflow series and 2 water temperature series are stationarized. The stochastic term for these series obtained with ARIMA is subsequently modeled. For the analysis, 9228 models are introduced. It is observed that seasonal standardization and spectral analysis eliminate the periodic term completely, while seasonal differencing maintains seasonal correlation structures. The obtained results indicate that all three methods present acceptable performance overall. However, model accuracy in monthly streamflow prediction is higher with seasonal differencing than with the other two methods. Another advantage of seasonal differencing over the other methods is that the monthly streamflow is never estimated as negative. Standardization is the best method for predicting monthly water temperature although it is quite similar to seasonal differencing, while spectral analysis performed the weakest in all cases. It is concluded that for each monthly seasonal series, seasonal differencing is the best stationarization method in terms of periodic effect elimination. Moreover, the monthly water temperature is predicted with more accuracy than monthly streamflow. The criteria of the average stochastic term divided by the amplitude of the periodic term obtained for monthly streamflow and monthly water temperature were 0.19 and 0.30, 0.21 and 0.13, and 0.07 and 0.04 respectively. As a result, the periodic term is more dominant than the stochastic term for water temperature in the monthly water temperature series compared to streamflow series.

  13. A foundation monograph of Convolvulus L. (Convolvulaceae).

    Science.gov (United States)

    Wood, John R I; Williams, Bethany R M; Mitchell, Thomas C; Carine, Mark A; Harris, David J; Scotland, Robert W

    2015-01-01

    .R.I.Wood & R.W.Scotland, comb. et stat. nov., Convolvuluscalvertiisubsp.ruprechtii (Boiss.) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvuluscephalopodussubsp.bushiricus (Bornm.) J.R.I.Wood & R.W.Scotland, stat. nov. The status of various infraspecific taxa is clarified and numerous taxa are lectotypified. This account represents a new initiative in terms of taxonomic monography, being an attempt to bring together the global approach of the traditional monograph with the more pragmatic and identification-focussed approach of most current floras while at the same time being informed by insights from molecular systematics.

  14. Determination of ionization potential of atomic gadolinium and its isotope effect. Analysis of unperturbed Rydberg series

    Energy Technology Data Exchange (ETDEWEB)

    Miyabe, Masabumi; Ohba, Masaki; Wakaida, Ikuo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1997-10-01

    Autoionizing Rydberg series converging to six states (0, 261.841, 633.273, 3082.011, 3427.274, 3444.235 cm{sup -1}) of Gd ion have been observed by using three-color three-step photoionization via ten different 2nd-step levels of J=0 or 1. While the perturbations with interlopers become significant in the region of n=30-35 for most of the observed series, long and well-defined series structures appeared in higher energy region. From an analysis of such unperturbed structures, the first ionization potential of Gd atom was estimated to be 49601.45 (30) cm{sup -1}. This is in good agreement with the previous value, but the accuracy is improved by about one order of magnitude. In addition, isotope effect on the ionization potential was also determined by isotope shifts of some Rydberg series. (author)

  15. A monograph of the Vochysiaceae ̶ I. Salvertia and Vochysia

    NARCIS (Netherlands)

    Stafleu, F.A.

    1948-01-01

    This publication is intended to be the first part of a taxonomic monograph of the family Vochysiaceae and deals with the genera Salvertia and Vochysia. Since Warming’s excellent treatise of the Brazilian species of this family in the Flora Brasiliensis (Vol. XIII, II,1875) a large number of new spec

  16. Use of High Throughput Screening Data in IARC Monograph ...

    Science.gov (United States)

    Purpose: Evaluation of carcinogenic mechanisms serves a critical role in IARC monograph evaluations, and can lead to “upgrade” or “downgrade” of the carcinogenicity conclusions based on human and animal evidence alone. Three recent IARC monograph Working Groups (110, 112, and 113) pioneered analysis of high throughput in vitro screening data from the U.S. Environmental Protection Agency’s ToxCast program in evaluations of carcinogenic mechanisms. Methods: For monograph 110, ToxCast assay data across multiple nuclear receptors were used to test the hypothesis that PFOA acts exclusively through the PPAR family of receptors, with activity profiles compared to several prototypical nuclear receptor-activating compounds. For monographs 112 and 113, ToxCast assays were systematically evaluated and used as an additional data stream in the overall evaluation of the mechanistic evidence. Specifically, ToxCast assays were mapped to 10 “key characteristics of carcinogens” recently identified by an IARC expert group, and chemicals’ bioactivity profiles were evaluated both in absolute terms (number of relevant assays positive for bioactivity) and relative terms (ranking with respect to other compounds evaluated by IARC, using the ToxPi methodology). Results: PFOA activates multiple nuclear receptors in addition to the PPAR family in the ToxCast assays. ToxCast assays offered substantial coverage for 5 of the 10 “key characteristics,” with the greates

  17. A monograph of the Vochysiaceae ̶ I. Salvertia and Vochysia

    NARCIS (Netherlands)

    Stafleu, F.A.

    1948-01-01

    This publication is intended to be the first part of a taxonomic monograph of the family Vochysiaceae and deals with the genera Salvertia and Vochysia. Since Warming’s excellent treatise of the Brazilian species of this family in the Flora Brasiliensis (Vol. XIII, II,1875) a large number of new

  18. Baby Boom Equals Career Bust. Monographs on Career Education.

    Science.gov (United States)

    Moore, Charles Guy

    Presenting the Baby Boom (1946-1965) as both a potential social problem and opportunity for American leadership, this monograph discusses the following aspects of this population concern: (1) its immediate and long-term impact on career opportunities for those college graduates who make up the baby boom generation; (2) its impact on those whose…

  19. Sex Bias in ASAT? ACER Research Monograph No. 24.

    Science.gov (United States)

    Adams, Raymond J.

    The Australian Scholastic Test (ASAT) was first used as a moderating device in the Australian Capitol Territory in 1977. Differences have been observed in the average performance of males and females on the test. The study reported in this monograph investigated the nature and origin of the score differences recorded for ASAT The research focused…

  20. The significance of field work in monographic studies

    Science.gov (United States)

    The focus of this paper is to document the clear and obvious advantages of field work for monographic studies. These advantages include: 1) ability to understand published distributions better and greatly expand these data, 2) access to taxonomic data obscured on herbarium sheets (as colors, odors, ...

  1. Nonstationary Langevin equation: statistical properties and application to explain effects observed in cardiological time series.

    Science.gov (United States)

    Kirchner, Jens; Meyer, Wolfgang; Elsholz, Markus; Hensel, Bernhard

    2007-08-01

    Using the Langevin equation we develop the model of a stochastic process subject to a given time-dependent regulatory mechanism. The effects of this nonstationarity on the statistical properties of the time series, i.e., on global and conditional probability densities and on the moments of the distribution, are derived. Application of these results on simple model trends allows one to approximate cardiological data and thus to explain effects recently observed in the reconstruction of the deterministic part of the Langevin equation for time series of heart rate.

  2. Analysis of effects of meteorological factors on dengue incidence in Sri Lanka using time series data.

    Science.gov (United States)

    Goto, Kensuke; Kumarendran, Balachandran; Mettananda, Sachith; Gunasekara, Deepa; Fujii, Yoshito; Kaneko, Satoshi

    2013-01-01

    In tropical and subtropical regions of eastern and South-eastern Asia, dengue fever (DF) and dengue hemorrhagic fever (DHF) outbreaks occur frequently. Previous studies indicate an association between meteorological variables and dengue incidence using time series analyses. The impacts of meteorological changes can affect dengue outbreak. However, difficulties in collecting detailed time series data in developing countries have led to common use of monthly data in most previous studies. In addition, time series analyses are often limited to one area because of the difficulty in collecting meteorological and dengue incidence data in multiple areas. To gain better understanding, we examined the effects of meteorological factors on dengue incidence in three geographically distinct areas (Ratnapura, Colombo, and Anuradhapura) of Sri Lanka by time series analysis of weekly data. The weekly average maximum temperature and total rainfall and the total number of dengue cases from 2005 to 2011 (7 years) were used as time series data in this study. Subsequently, time series analyses were performed on the basis of ordinary least squares regression analysis followed by the vector autoregressive model (VAR). In conclusion, weekly average maximum temperatures and the weekly total rainfall did not significantly affect dengue incidence in three geographically different areas of Sri Lanka. However, the weekly total rainfall slightly influenced dengue incidence in the cities of Colombo and Anuradhapura.

  3. A foundation monograph of Convolvulus L. (Convolvulaceae)

    Science.gov (United States)

    Wood, John R.I.; Williams, Bethany R.M.; Mitchell, Thomas C.; Carine, Mark A.; Harris, David J.; Scotland, Robert W.

    2015-01-01

    ., Convolvulus rottlerianus subsp. stocksii (Boiss.) J.R.I.Wood & R.W.Scotland, comb. et stat. nov., Convolvulus calvertii subsp. ruprechtii (Boiss.) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulus cephalopodus subsp. bushiricus (Bornm.) J.R.I.Wood & R.W.Scotland, stat. nov. The status of various infraspecific taxa is clarified and numerous taxa are lectotypified. This account represents a new initiative in terms of taxonomic monography, being an attempt to bring together the global approach of the traditional monograph with the more pragmatic and identification-focussed approach of most current floras while at the same time being informed by insights from molecular systematics. PMID:26140023

  4. The Effects of Physical Attractiveness and Anxiety on Heterosexual Attraction Over a Series of Five Encounters

    Science.gov (United States)

    Mathes, Eugene W.

    1975-01-01

    The "information availability model" of heterosexual attraction was tested by having subjects go on a series of five encounters. It was found that both physical attractiveness and the personality variable, anxiety, had early and continuous effects on liking. It was concluded the model is an inadequate explanation of heterosexual…

  5. Effects of Series Elasticity on the Human Knee Extension Torque-Angle Relationship in Vivo

    Science.gov (United States)

    Kubo, Keitaro; Ohgo, Kazuya; Takeishi, Ryuichi; Yoshinaga, Kazunari; Tsunoda, Naoya; Kanehisa, Hiroaki; Fukunaga, Tetsuo

    2006-01-01

    The purpose of this study was to investigate the effects of series elasticity on the torque-angle relationship of the knee extensors in vivo. Forty-two men volunteered to take part in the present study. The participants performed maximal voluntary isometric contractions at eight knee-joint angles (40, 50, 60, 70, 80, 90, 100, 110[degree]). The…

  6. Bullying and School Attendance: A Case Study of Senior High School Students in Ghana. CREATE Pathways to Access. Research Monograph No. 41

    Science.gov (United States)

    Dunne, Mairead; Bosumtwi-Sam, Cynthia; Sabates, Ricardo; Owusu, Andrew

    2010-01-01

    This monograph analyses the effects of bullying on school attendance among senior high school students in Ghana. A strong correlation is found between being bullied and having poor attendance. The effects of emotional problems and of peer friendships on this correlation are then examined. For both boys and girls, having emotional problems is…

  7. Intercultural Education Series. The Americas and Self-Identification.

    Science.gov (United States)

    Jones, Earl, Ed.; Dean, Frances, Ed.

    This is the final monograph in the Programa de Educacion Interamericana resource series on Latin America: SO 001 424 through SO 001 428. Two main sections are contained here: 1) philosophical and methodological approaches to the problems of teaching the social studies, and 2) ammunition in knowing the Americas so they can be taught better. The…

  8. Monograph use at an academic health sciences library: the first three years of shelf life

    Science.gov (United States)

    Blecic, Deborah D.

    2000-01-01

    Objective: To study the circulation of monographs during the first three years of shelf life at an academic health sciences library. Method: A record was kept of monographs added to the circulating collection from mid-1994 to mid-1995. After three years, each monograph was located and the number of times it circulated during the first, second, and third year of shelf life determined by counting checkout stamps on the circulation slip. Results: Of the 1,958 monographs studied, 1,674 had complete data for the first three years of shelf life. Of those 1,674 titles, 81.48% circulated at least once. A total of 7,659 circulations were recorded; 38.69% occurred in the first year of shelf life, 32.37% in the second year, and 28.95% in the third year. The data did not fit the well-known 80/20 rule. Instead, approximately 38% of monographs accounted for 80% of circulation. A small percentage, 2.21%, of monographs accounted for a substantial percentage of circulation, 21.84%. Conclusions: A large percentage of the monographs circulated and use did not decline sharply with age within the first three years of shelf life, indicating a high demand for monographs at this academic health sciences library. These results, combined with the findings of earlier studies, suggested two possibilities. First, academic health sciences libraries might exhibit use of a higher percentage of monograph acquisitions than other types of libraries; or, second, a low monograph-to-user ratio might result in a higher percentage of monographs being used. Perhaps both factors contributed to the results found in this study. Further investigation would be needed to determine the extent to which library type and monograph-to-user ratio influenced monograph use. PMID:10783969

  9. ‘The Returned’: on the future of monographic books

    Directory of Open Access Journals (Sweden)

    Mercedes Bunz

    2014-04-01

    Full Text Available This article evaluates the current state of academic book publishing based on the findings of the Hybrid Publishing Lab's business model research. With students relying more and more on Google and Wikipedia, the role of books within today's university studies is a difficult one. From the perspective of publishers, open access (OA embracing the digital is seen as one potential way to bridge this gap between online search engines and traditional monographs. To illustrate this further, the article delivers an overview of its findings, which highlight changes in academic publishing: publishers have switched their emphasis from delivering a product to creating a service, whereby the author rather than the reader becomes their most focused-on customer. Research frameworks, funding and conventions about academic careers, however, often still need to adjust to this new development. If these frameworks acknowledge and foster OA publishing, and new experiments with collaborative book productions flourish, the monograph will have a future.

  10. Monograph on propagation of sound waves in curved ducts

    Science.gov (United States)

    Rostafinski, Wojciech

    1991-01-01

    After reviewing and evaluating the existing material on sound propagation in curved ducts without flow, it seems strange that, except for Lord Rayleigh in 1878, no book on acoustics has treated the case of wave motion in bends. This monograph reviews the available analytical and experimental material, nearly 30 papers published on this subject so far, and concisely summarizes what has been learned about the motion of sound in hard-wall and acoustically lined cylindrical bends.

  11. Circulation of core collection monographs in an academic medical library.

    Science.gov (United States)

    Schmidt, C M; Eckerman, N L

    2001-04-01

    Academic medical librarians responsible for monograph acquisition face a challenging task. From the plethora of medical monographs published each year, academic medical librarians must select those most useful to their patrons. Unfortunately, none of the selection tools available to medical librarians are specifically intended to assist academic librarians with medical monograph selection. The few short core collection lists that are available are intended for use in the small hospital or internal medicine department library. As these are the only selection tools available, however, many academic medical librarians spend considerable time reviewing these collection lists and place heavy emphasis on the acquisition of listed books. The study reported here was initiated to determine whether the circulation of listed books in an academic library justified the emphasis placed on the acquisition of these books. Circulation statistics for "listed" and "nonlisted" books in the hematology (WH) section of Indiana University School of Medicine's Ruth Lilly Medical Library were studied. The average circulation figures for listed books were nearly two times as high as the corresponding figures for the WH books in general. These data support the policies of those academic medical libraries that place a high priority on collection of listed books.

  12. Experience of a monographic tuberculosis unit: the first 500 cases.

    Science.gov (United States)

    González-Moreno, Juan; García-Gasalla, Mercedes; Cifuentes Luna, Carmen; Mir Villadrich, Isabel; Pareja Bezares, Antonio; Navarro Fernández, Verónica; Serrano Bujalance, Araceli; Pérez Seco, M Cruz; Payeras Cifre, Antonio

    2013-10-01

    Tuberculosis (TB) remains a highly prevalent and potentially severe disease. However, since 2002 the annual incidence has been decreasing both worldwide and in Spain, where the incidence varies widely between regions. The main objective of this study is to describe the experience of a monographic TB unit in a second level hospital. A descriptive study was carried out which included all cases of TB diagnosed in a monographic unit of a secondary hospital between 2003 and 2011. Demographic, clinical, epidemiological and microbiological data were recorded. We analyzed 500 TB cases and found an increasing annual incidence in all subgroups, including native and immigrant populations. Most cases (63.8%) were male, with a median age of 36 years (range 8 months-90 years). In total, 39.8% of patients were foreign born. Coinfection with human immunodeficiency virus was found in 11% of cases. The pulmonary form was most frequently diagnosed (63.8%). Overall mortality was 5.8% with no significant differences between groups (including foreign born and human immunodeficiency virus positive patients). Although TB incidence is globally decreasing, in our study we found an increasing number of cases in recent years in all subgroups, which can be explained by this being a monographic unit with an intensive contact tracing program. Copyright © 2012 SEPAR. Published by Elsevier Espana. All rights reserved.

  13. Monograph of Keçiören Municipality

    Directory of Open Access Journals (Sweden)

    Savaş Zafer Şahin

    2015-12-01

    Full Text Available In Turkey, urban administration can be defined from a judicial perspective as the bundle of powers vested in municipalities. It is known that throughout republican history, municipalities, using these powers, have differentiated themselves via their own internal dynamics in parallel to the evolution of public policy and changes in legislation. Yet, it is obvious that there are important gaps in understanding this differentiation taking into consideration the structural conditions of individual municipalities. In particular, in order to thoroughly understand municipalities, it is important to consider periodical pictures of how each municipality has been affected by waves of decentralization and centralization experienced over the last thirty years. In this respect, this monograph, using the same monographic approach developed for the Çankaya Municipality, provides a picture of the existing situation of Ankara’s Keçiören Municipality and presents related problems and potential. This monograph, based on qualitative and quantitative research, presents a holistic evaluation of Keçiören Municipality in terms of its external environment, provision of services, decision-making processes, use of technology and communications.

  14. Reconstruction of effective cloud field geometry from series of sunshine number

    Science.gov (United States)

    Badescu, Viorel; Paulescu, Marius; Brabec, Marek

    2016-07-01

    A new method is proposed for extracting the parameters of effective cloud field models from time series of sunshine number (SSN). Data of SSN number and point cloudiness during 2009 and 2010 at Timisoara (Romania, South Eastern Europe; temperate continental climate) are used to illustrate the method. Two procedures of fitting the estimated point cloudiness to the observed point cloudiness data are proposed and tested. Seven simple effective cloud field models are analyzed. All models underestimate the point cloudiness. The MBE ranges between - 0.06 and - 0.23 while RMSE between 0.15 and 0.38, depending on the month and the duration of the SSN data averaging interval. The best model is based on a field of clouds of semicircle form. This agrees with previous results obtained in the semi-arid climate of Great South Plains in US. The dynamics of the effective cloud field is reconstructed during all months of 2010 at Timisoara. The time series of effective cloud fields are dominated by semicircle clouds but short episodes of semielliptic clouds, ellipsoid clouds, truncated cone clouds and cuboidal clouds are included in the series.

  15. Effect of Asymmetrical Edge Disconnection on Equivalent Series Resistance of Metalized Polypropylene Capacitors

    OpenAIRE

    J Sivakumar; S. Usa; M.A. Panneerselvam

    2014-01-01

    In order to investigate the effect of asymmetrical partial edge disconnection on the Equivalent Series Resistance (ESR) of Metalized polypropylene capacitors an experimental study has been made. Theoretical analysis made using PSPICE simulation package reveals that electrode resistance of individual turn rises from 10 to 30% depending on the location of the turn. This rise is not measureable at all the frequencies as ESR is frequency dependent and it includes resistance due to electrodes and ...

  16. The effects of watching American TV series on tertiary level EFL learners' use of formulaic language

    OpenAIRE

    Erdemir, Fatma Birgül

    2014-01-01

    Ankara : The Department of Teaching English as a Foreign Language, Bilkent University, 2014. Thesis (Master's) -- Bilkent University, 2014. Includes bibliographical references leaves 77-84. This study investigates the effects of watching an American TV Series, How I Met Your Mother (HIMYM), on tertiary level English as a Foreign Language (EFL) learners’ use of formulaic language. The participants were 66 Upper Intermediate level students studying at Akdeniz University, Schoo...

  17. Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups.

    Science.gov (United States)

    Chiu, Weihsueh A; Guyton, Kathryn Z; Martin, Matthew T; Reif, David M; Rusyn, Ivan

    2017-07-24

    Evidence regarding carcinogenic mechanisms serves a critical role in International Agency for Research on Cancer (IARC) Monograph evaluations. Three recent IARC Working Groups pioneered inclusion of the US Environmental Protection Agency (EPA) ToxCast program high-throughput screening (HTS) data to supplement other mechanistic evidence. In Monograph V110, HTS profiles were compared between perfluorooctanoic acid (PFOA) and prototypical activators across multiple nuclear receptors. For Monograph V112 -113, HTS assays were mapped to 10 key characteristics of carcinogens identified by an IARC expert group, and systematically considered as an additional mechanistic data stream. Both individual assay results and ToxPi-based rankings informed mechanistic evaluations. Activation of multiple nuclear receptors in HTS assays showed that PFOA targets peroxisome proliferator activated and other receptors. ToxCast assays substantially covered 5 of 10 key characteristics, corroborating literature evidence of "induces oxidative stress" and "alters cell proliferation, cell death or nutrient supply" and filling gaps for "modulates receptor-mediated effects." Thus, ToxCast HTS data were useful both in evaluating specific mechanistic hypotheses and in the overall evaluation of mechanistic evidence. However, additional HTS assays are needed to provide more comprehensive coverage of the 10 key characteristics of carcinogens that form the basis of current IARC mechanistic evaluations.

  18. There's alcohol in my soap: portrayal and effects of alcohol use in a popular television series.

    Science.gov (United States)

    van Hoof, Joris J; de Jong, Menno D T; Fennis, Bob M; Gosselt, Jordy F

    2009-06-01

    Two studies are reported addressing the media influences on adolescents' alcohol-related attitudes and behaviours. A content analysis was conducted to investigate the prevalence of alcohol portrayal in a Dutch soap series. The coding scheme covered the alcohol consumption per soap character, drinking situations and drinking times. Inter-coder reliability was satisfactory. The results showed that alcohol portrayal was prominent and that many instances of alcohol use reflected undesirable behaviours. To assess the influence of such alcohol cues on adolescents, a 2x2 experiment was conducted focusing on the separate and combined effects of alcohol portrayal in the soap series and surrounding alcohol commercials. Whereas the alcohol commercials had the expected effects on adolescents' attitudes, the alcohol-related soap content only appeared to have unexpected effects. Adolescents who were exposed to the alcohol portrayal in the soap series had a less positive attitude towards alcohol and lower drinking intentions. Implications of these findings for health policy and future research are discussed.

  19. Effects of linear trends on estimation of noise in GNSS position time-series

    Science.gov (United States)

    Dmitrieva, K.; Segall, P.; Bradley, A. M.

    2017-01-01

    A thorough understanding of time-dependent noise in Global Navigation Satellite System (GNSS) position time-series is necessary for computing uncertainties in any signals found in the data. However, estimation of time-correlated noise is a challenging task and is complicated by the difficulty in separating noise from signal, the features of greatest interest in the time-series. In this paper, we investigate how linear trends affect the estimation of noise in daily GNSS position time-series. We use synthetic time-series to study the relationship between linear trends and estimates of time-correlated noise for the six most commonly cited noise models. We find that the effects of added linear trends, or conversely de-trending, vary depending on the noise model. The commonly adopted model of random walk (RW), flicker noise (FN) and white noise (WN) is the most severely affected by de-trending, with estimates of low-amplitude RW most severely biased. FN plus WN is least affected by adding or removing trends. Non-integer power-law noise estimates are also less affected by de-trending, but are very sensitive to the addition of trend when the spectral index is less than one. We derive an analytical relationship between linear trends and the estimated RW variance for the special case of pure RW noise. Overall, we find that to ascertain the correct noise model for GNSS position time-series and to estimate the correct noise parameters, it is important to have independent constraints on the actual trends in the data.

  20. Effect of water hardness on cardiovascular mortality: an ecological time series approach.

    Science.gov (United States)

    Lake, I R; Swift, L; Catling, L A; Abubakar, I; Sabel, C E; Hunter, P R

    2010-12-01

    Numerous studies have suggested an inverse relationship between drinking water hardness and cardiovascular disease. However, the weight of evidence is insufficient for the WHO to implement a health-based guideline for water hardness. This study followed WHO recommendations to assess the feasibility of using ecological time series data from areas exposed to step changes in water hardness to investigate this issue. Monthly time series of cardiovascular mortality data, subdivided by age and sex, were systematically collected from areas reported to have undergone step changes in water hardness, calcium and magnesium in England and Wales between 1981 and 2005. Time series methods were used to investigate the effect of water hardness changes on mortality. No evidence was found of an association between step changes in drinking water hardness or drinking water calcium and cardiovascular mortality. The lack of areas with large populations and a reasonable change in magnesium levels precludes a definitive conclusion about the impact of this cation. We use our results on the variability of the series to consider the data requirements (size of population, time of water hardness change) for such a study to have sufficient power. Only data from areas with large populations (>500,000) are likely to be able to detect a change of the size suggested by previous studies (rate ratio of 1.06). Ecological time series studies of populations exposed to changes in drinking water hardness may not be able to provide conclusive evidence on the links between water hardness and cardiovascular mortality unless very large populations are studied. Investigations of individuals may be more informative.

  1. A Simulation of the Effects of Receive Field Contrast on Motion-Corrected EPI Time Series

    CERN Document Server

    Sheltraw, D

    2012-01-01

    The receive field of MRI imparts an image contrast which is spatially fixed relative to the receive coil. If motion correction is used to correct subject motion occurring during an EPI time series then the receiver contrast will effectively move relative to the subject and produce temporal modulations in the image amplitude. This effect, which we will call the RFC-MoCo effect, may have consequences in the analysis and interpretation of fMRI results. There are many potential causes of motion-related noise and systematic error in EPI time series and isolating the RFC-MoCo effect would be difficult. Therefore, we have undertaken a simulation of this effect to better understand its severity. The simulations examine this effect for a receive-only single-channel 16-leg birdcage coil and a receive-only 12-channel phased array. In particular we study: (1) The effect size; (2) Its consequences to the temporal correlations between signals arising at different spatial locations (spatial-temporal correlations) as is ofte...

  2. Volterra series based predistortion for broadband RF power amplifiers with memory effects

    Institute of Scientific and Technical Information of China (English)

    Jin Zhe; Song Zhihuan; He Jiaming

    2008-01-01

    RF power amplifiers(PAs)are usually considered as memoryless devices in most existing predistortion techniques.However,in broadband communication systems,such as WCDMA,the PA memory effects are significant,and memoryless predistortion cannot linearize the PAs effectively.After analyzing the PA memory effects,a novel predistortion method based on the simplified Volterra series is proposed to linearize broadband RF PAs with memory effects.The indirect learning architecture is adopted to design the predistortion scheme and the recursive least squares algorithm with forgetting factor is applied to identify the parameters of the predistorter.Simulation results show that the proposed predistortion method can compensate the nonlinear distortion and memory effects of broadband RF PAs effectively.

  3. Richly parameterized linear models additive, time series, and spatial models using random effects

    CERN Document Server

    Hodges, James S

    2013-01-01

    A First Step toward a Unified Theory of Richly Parameterized Linear ModelsUsing mixed linear models to analyze data often leads to results that are mysterious, inconvenient, or wrong. Further compounding the problem, statisticians lack a cohesive resource to acquire a systematic, theory-based understanding of models with random effects.Richly Parameterized Linear Models: Additive, Time Series, and Spatial Models Using Random Effects takes a first step in developing a full theory of richly parameterized models, which would allow statisticians to better understand their analysis results. The aut

  4. Eta Products and Theta Series Identities

    CERN Document Server

    Kohler, Gunter

    2011-01-01

    This monograph deals with products of Dedekind's eta function, with Hecke theta series on quadratic number fields, and with "Eisenstein series." The author brings to the public the large number of identities that have been discovered over the past 20 years, the majority of which have not been published elsewhere. This book will be of interest to graduate students and scholars in the field of number theory and, in particular, modular forms. It is not an introductory text in this field. Nevertheless, some theoretical background material is presented that is important for understanding

  5. Uniting Mandelbrot’s Noah and Joseph Effects in Toy Models of Natural Hazard Time Series

    Science.gov (United States)

    Credgington, D.; Watkins, N. W.; Chapman, S. C.; Rosenberg, S. J.; Sanchez, R.

    2009-12-01

    The forecasting of extreme events is a highly topical, cross-disciplinary problem. One aspect which is potentially tractable even when the events themselves are stochastic is the probability of a “burst” of a given size and duration, defined as the area between a time series and a constant threshold. Many natural time series depart from the simplest, Brownian, case and in the 1960s Mandelbrot developed the use of fractals to describe these departures. In particular he proposed two kinds of fractal model to capture the way in which natural data is often persistent in time (his “Joseph effect”, common in hydrology and exemplified by fractional Brownian motion) and/or prone to heavy tailed jumps (the “Noah effect”, typical of economic index time series, for which he gave Levy flights as an examplar). Much of the earlier modelling, however, has emphasised one of the Noah and Joseph parameters (the tail exponent mu and one derived from the temporal behaviour such as power spectral beta) at the other one's expense. I will describe work [1] in which we applied a simple self-affine stable model-linear fractional stable motion (LFSM)-which unifies both effects to better describe natural data, in this case from space physics. I will show how we have resolved some contradictions seen in earlier work, where purely Joseph or Noah descriptions had been sought. I will also show recent work [2] using numerical simulations of LFSM and simple analytic scaling arguments to study the problem of the area between a fractional Levy model time series and a threshold. [1] Watkins et al, Space Science Reviews [2005] [2] Watkins et al, Physical Review E [2009

  6. Leadership Effectiveness. ACSA School Management Digest, Series 1, No. 16. ERIC/CEM Research Analysis Series Number 44.

    Science.gov (United States)

    Mazzarella, Jo Ann

    Many educational administrators are too overwhelmed by paperwork and too short of time, resources, and training, to be effective leaders. Yet some educators and schools are finding ways to make good leadership easier through improving time management skills, providing assistants, instituting administrative training programs, and cutting paperwork.…

  7. J. W. Gitt: The Cold War's "Voice in the Wilderness." Journalism Monographs Number Ninety-One.

    Science.gov (United States)

    Hamilton, Mary Allienne

    This journalism monograph deals with Josiah W. Gitt and his newspaper, "The Gazette and Daily," which existed from 1915 to 1970 and was referred to as "the voice in the wilderness" because of its stand on controversial issues. The monograph discusses the "Gazette and Daily," its views, Gitt's employees, the…

  8. The Caribbean News Agency: Third World Model. Journalism Monographs Number 71.

    Science.gov (United States)

    Cuthbert, Marlene

    This monograph is a history of the Caribbean News Agency (CANA), which is jointly owned by private and public mass media of its region and independent of both governments and foreign news agencies. It is proposed that CANA may provide a unique model of an independent, regional third-world news agency. Sections of the monograph examine (1) CANA's…

  9. Use of High Throughput Screening Data in IARC Monograph Evaluations (SOT)

    Science.gov (United States)

    Purpose: Evaluation of carcinogenic mechanisms serves a critical role in IARC monograph evaluations, and can lead to “upgrade” or “downgrade” of the carcinogenicity conclusions based on human and animal evidence alone. Three recent IARC monograph Working Groups (110, 112, and 11...

  10. Nontidal ocean loading: amplitudes and potential effects in GPS height time series

    Science.gov (United States)

    van Dam, T.; Collilieux, X.; Wuite, J.; Altamimi, Z.; Ray, J.

    2012-11-01

    Ocean bottom pressure (OBP) changes are caused by a redistribution of the ocean's internal mass that are driven by atmospheric circulation, a change in the mass entering or leaving the ocean, and/or a change in the integrated atmospheric mass over the ocean areas. The only previous global analysis investigating the magnitude of OBP surface displacements used older OBP data sets (van Dam et al. in J Geophys Res 129:507-517, 1997). Since then significant improvements in meteorological forcing models used to predict OBP have been made, augmented by observations from satellite altimetry and expendable bathythermograph profiles. Using more recent OBP estimates from the Estimating the Circulation and Climate of the Ocean (ECCO) project, we reassess the amplitude of the predicted effect of OBP on the height coordinate time series from a global distribution of GPS stations. OBP-predicted loading effects display an RMS scatter in the height of between 0.2 and 3.7 mm, larger than previously reported but still much smaller (by a factor of 2) than the scatter observed due to atmospheric pressure loading. Given the improvement in GPS hardware and data analysis techniques, the OBP signal is similar to the precision of weekly GPS height coordinates. We estimate the effect of OBP on GPS height coordinate time series using the MIT reprocessed solution, mi1. When we compare the predicted OBP height time series with mi1, we find that the scatter is reduced over all stations by 0.1 mm on average with reductions as high as 0.7 mm at some stations. More importantly we are able to reduce the scatter on 65 % of the stations investigated. The annual component of the OBP signal is responsible for 80 % of the reduction in scatter on average. We find that stations located close to semi-enclosed bays or seas are affected by OBP loading to a greater extent than other stations.

  11. 78 FR 67371 - Draft Report on Carcinogens Monographs for ortho-Toluidine and Pentachlorophenol and By-products...

    Science.gov (United States)

    2013-11-12

    ... HUMAN SERVICES National Institutes of Health Draft Report on Carcinogens Monographs for ortho-Toluidine... Report on Carcinogens (RoC) Monographs for ortho-Toluidine and Pentachlorophenol and By-products of its... a.m. until adjournment, approximately 11:30 a.m. Document Availability: Draft monographs...

  12. 78 FR 51733 - Draft Report on Carcinogens Monographs for ortho-Toluidine and Pentachlorophenol and By-Products...

    Science.gov (United States)

    2013-08-21

    ... HUMAN SERVICES National Institutes of Health Draft Report on Carcinogens Monographs for ortho-Toluidine... Carcinogens (RoC) Monographs for ortho-Toluidine and Pentachlorophenol and By-products of its Synthesis.... Document Availability: Draft monographs will be available by August 28, 2013, at...

  13. Effect of spatial averaging on multifractal properties of meteorological time series

    Science.gov (United States)

    Hoffmann, Holger; Baranowski, Piotr; Krzyszczak, Jaromir; Zubik, Monika

    2016-04-01

    Introduction The process-based models for large-scale simulations require input of agro-meteorological quantities that are often in the form of time series of coarse spatial resolution. Therefore, the knowledge about their scaling properties is fundamental for transferring locally measured fluctuations to larger scales and vice-versa. However, the scaling analysis of these quantities is complicated due to the presence of localized trends and non-stationarities. Here we assess how spatially aggregating meteorological data to coarser resolutions affects the data's temporal scaling properties. While it is known that spatial aggregation may affect spatial data properties (Hoffmann et al., 2015), it is unknown how it affects temporal data properties. Therefore, the objective of this study was to characterize the aggregation effect (AE) with regard to both temporal and spatial input data properties considering scaling properties (i.e. statistical self-similarity) of the chosen agro-meteorological time series through multifractal detrended fluctuation analysis (MFDFA). Materials and Methods Time series coming from years 1982-2011 were spatially averaged from 1 to 10, 25, 50 and 100 km resolution to assess the impact of spatial aggregation. Daily minimum, mean and maximum air temperature (2 m), precipitation, global radiation, wind speed and relative humidity (Zhao et al., 2015) were used. To reveal the multifractal structure of the time series, we used the procedure described in Baranowski et al. (2015). The diversity of the studied multifractals was evaluated by the parameters of time series spectra. In order to analyse differences in multifractal properties to 1 km resolution grids, data of coarser resolutions was disaggregated to 1 km. Results and Conclusions Analysing the spatial averaging on multifractal properties we observed that spatial patterns of the multifractal spectrum (MS) of all meteorological variables differed from 1 km grids and MS-parameters were biased

  14. Employer Expectations, Peer Effects and Productivity: Evidence from a Series of Field Experiments

    CERN Document Server

    Horton, John J

    2010-01-01

    This paper reports the results of a series of field experiments designed to investigate how peer effects operate in a real work setting. Workers were hired from an online labor market to perform an image-labeling task and, in some cases, to evaluate the work product of other workers. These evaluations had financial consequences for both the evaluating worker and the evaluated worker. The experiments showed that on average, evaluating high-output work raised an evaluator's subsequent productivity, with larger effects for evaluators that are themselves highly productive. The content of the subject evaluations themselves suggest one mechanism for peer effects: workers readily punished other workers whose work product exhibited low output/effort. However, non-compliance with employer expectations did not, by itself, trigger punishment: workers would not punish non-complying workers so long as the evaluated worker still exhibited high effort. A worker's willingness to punish was strongly correlated with their own ...

  15. An Effective Hamiltonian for Symmetric Diarylmethanes from a Series of Analogous Quantum Chemical Models

    CERN Document Server

    Olsen, Seth

    2012-01-01

    We propose a single effective Hamiltonian to describe the low-energy electronic structure of a series of symmetric cationic diarylmethanes, which are all bridge-substituted derivatives of Michler's Hydrol Blue. Three-state diabatic Hamiltonians for the dyes are calculated using four-electron three-orbital state-averaged complete active space self-consistent field and multi-state multi-reference perturbation theory models. The approach takes advantage of an isolobal analogy that can be established between the orbitals spanning the active spaces of the different substituted dyes. The solutions of the chemical problem are expressed in a diabatic Hilbert space that is analogous to classical resonance models. The effective Hamiltonians for all dyes can be fit to a single functional form that depends on the mixing angle between a bridge-charged diabatic state and a superposition representing the canonical resonance. We find that the structure of the bridge-charged state changes in a regular fashion across the serie...

  16. Hilbert series and operator bases with derivatives in effective field theories

    Science.gov (United States)

    Henning, Brian; Lu, Xiaochuan; Melia, Tom; Murayama, Hitoshi

    2016-10-01

    We introduce a systematic framework for counting and finding independent operators in effective field theories, taking into account the redundancies associated with use of the classical equations of motion and integration by parts. By working in momentum space, we show that the enumeration problem can be mapped onto that of understanding a polynomial ring in the field momenta. All-order information about the number of independent operators in an effective field theory is encoded in a geometrical object of the ring known as the Hilbert series. We obtain the Hilbert series for the theory of N real scalar fields in (0+1) dimensions—an example, free of space-time and internal symmetries, where aspects of our framework are most transparent. Although this is as simple a theory involving derivatives as one could imagine, it provides fruitful lessons to be carried into studies of more complicated theories: we find surprising and rich structure from an interplay between integration by parts and equations of motion and a connection with SL(2,C) representation theory, which controls the structure of the operator basis.

  17. Stochastic modeling for time series InSAR: with emphasis on atmospheric effects

    Science.gov (United States)

    Cao, Yunmeng; Li, Zhiwei; Wei, Jianchao; Hu, Jun; Duan, Meng; Feng, Guangcai

    2017-08-01

    Despite the many applications of time series interferometric synthetic aperture radar (TS-InSAR) techniques in geophysical problems, error analysis and assessment have been largely overlooked. Tropospheric propagation error is still the dominant error source of InSAR observations. However, the spatiotemporal variation of atmospheric effects is seldom considered in the present standard TS-InSAR techniques, such as persistent scatterer interferometry and small baseline subset interferometry. The failure to consider the stochastic properties of atmospheric effects not only affects the accuracy of the estimators, but also makes it difficult to assess the uncertainty of the final geophysical results. To address this issue, this paper proposes a network-based variance-covariance estimation method to model the spatiotemporal variation of tropospheric signals, and to estimate the temporal variance-covariance matrix of TS-InSAR observations. The constructed stochastic model is then incorporated into the TS-InSAR estimators both for parameters (e.g., deformation velocity, topography residual) estimation and uncertainty assessment. It is an incremental and positive improvement to the traditional weighted least squares methods to solve the multitemporal InSAR time series. The performance of the proposed method is validated by using both simulated and real datasets.

  18. [The HMPC monograph on Hypericum: Background, development, contents].

    Science.gov (United States)

    Länger, Reinhard

    2010-12-01

    The adoption of the EU community monograph on Hypericum constitutes a milestone in the process of harmonisation of herbal medicinal products within the European Community. The assessment of the published clinical data revealed that for two types of extracts the evidence of the efficacy in mild to moderate depressive episodes compared to placebo or standard medication was found to be acceptable. Additionally, a sufficient efficacy in relapse prophylaxis could be demonstrated for these two herbal preparations. For some other dry extracts, the efficacy in the short-term treatment of symptoms in mild depressive disorders was found to be substantiated. Short-term treatment with preparations containing low amounts of hyperforin did not increase cytochrome P450 enzyme activity. Therefore the oral administration of traditional herbal preparations is restricted to two weeks. In the case that an applicant demonstrates that the daily intake of hyperforin is below 1 mg the warnings on interactions may be omitted in traditional herbal medicinal products. Additionally the cutaneous administration of traditional liquid herbal preparations for the traditional use in symptomatic treatment of minor inflammations of the skin and as an aid in healing minor wounds was included in the monograph.

  19. The effects of neck and trunk stabilization exercises on cerebral palsy children's static and dynamic trunk balance : case series

    National Research Council Canada - National Science Library

    JI-WON SHIN; GUI-BIN SONG; JOOYEON KO

    2017-01-01

    [Abstract.] [Purpose] The purpose of this case series was to examination the effects of trunk and neck stabilization exercise on the static, dynamic trunk balance abilities of children with cerebral palsy...

  20. Assessments of higher-order ionospheric effects on GPS coordinate time series: A case study of CMONOC with longer time series

    Science.gov (United States)

    Jiang, Weiping; Deng, Liansheng; Zhou, Xiaohui; Ma, Yifang

    2014-05-01

    Higher-order ionospheric (HIO) corrections are proposed to become a standard part for precise GPS data analysis. For this study, we deeply investigate the impacts of the HIO corrections on the coordinate time series by implementing re-processing of the GPS data from Crustal Movement Observation Network of China (CMONOC). Nearly 13 year data are used in our three processing runs: (a) run NO, without HOI corrections, (b) run IG, both second- and third-order corrections are modeled using the International Geomagnetic Reference Field 11 (IGRF11) to model the magnetic field, (c) run ID, the same with IG but dipole magnetic model are applied. Both spectral analysis and noise analysis are adopted to investigate these effects. Results show that for CMONOC stations, HIO corrections are found to have brought an overall improvement. After the corrections are applied, the noise amplitudes decrease, with the white noise amplitudes showing a more remarkable variation. Low-latitude sites are more affected. For different coordinate components, the impacts vary. The results of an analysis of stacked periodograms show that there is a good match between the seasonal amplitudes and the HOI corrections, and the observed variations in the coordinate time series are related to HOI effects. HOI delays partially explain the seasonal amplitudes in the coordinate time series, especially for the U component. The annual amplitudes for all components are decreased for over one-half of the selected CMONOC sites. Additionally, the semi-annual amplitudes for the sites are much more strongly affected by the corrections. However, when diplole model is used, the results are not as optimistic as IGRF model. Analysis of dipole model indicate that HIO delay lead to the increase of noise amplitudes, and that HIO delays with dipole model can generate false periodic signals. When dipole model are used in modeling HIO terms, larger residual and noise are brought in rather than the effective improvements.

  1. Effect of extreme value loss on long-term correlated time series

    Science.gov (United States)

    Yuan, Naiming; Fu, Zuntao; Li, Huiqun; Mao, Jiangyu

    2012-07-01

    Effects of extreme value loss on long-term correlated time series are analyzed by means of detrended fluctuation analysis (DFA) and power spectral density analysis. Weaker memory can be detected after removing of extreme values for the artificial long-term correlated data, indicating the emergence of extreme events may be closely related to long-term memory. For observational temperature records, similar results are obtained, but not in all stations. For example, in some stations, only extending of scaling range to smaller time scales occurs, which may be due to the asymmetric distribution of values in the record. By comparing our findings with previous works, clustered positions of the extreme events are recognized as an important property in long-term correlated records. Through a simple numerical test, close relations between extreme events and long-term memory are discovered, which is helpful for our understanding of the effects of extreme value loss on long-term correlated records.

  2. Series-coupled silicon racetrack resonators and the Vernier effect: theory and measurement.

    Science.gov (United States)

    Boeck, Robi; Jaeger, Nicolas A; Rouger, Nicolas; Chrostowski, Lukas

    2010-11-22

    Silicon-on-insulator racetrack resonators can be used as multiplexers in wavelength division multiplexing applications. The free spectral range should be comparable to the span of the C-band so that a maximum number of channels can be multiplexed. However, the free spectral range is inversely proportional to the length of the resonator and, therefore, bending losses can become non-negligible. A viable alternative to increase the free spectral range is to use the Vernier effect. In this work, we present the theory of series-coupled racetrack resonators exhibiting the Vernier effect. We demonstrate the experimental performance of the device using silicon-on-insulator strip waveguides. The extended free spectral range is 36 nm and the interstitial peak suppression is from 9 dB to 17 dB.

  3. Modelling the neurovascular habituation effect on fMRI time series

    Energy Technology Data Exchange (ETDEWEB)

    Ciuciu, Ph.; Sockeel, S.; Vincent, T. [NeuroSpin/CEA, F-91191 Gif-sur-Yvette (France); Idier, J. [IRCCyN/CNRS, 1 rue de la Noe 44300 Nantes (France)

    2009-07-01

    In this paper, a novel non-stationary model of functional Magnetic Resonance Imaging (fMRI) time series is proposed. It allows us to account for some putative habituation effect arising in event-related fMRI paradigms that involves the so-called repetition-suppression phenomenon and induces decreasing magnitude responses over successive trials. Akin, this model is defined over functionally homogeneous regions-of-interest (ROIs) and embedded in a joint detection-estimation approach of brain activity. Importantly, its non-stationarity character is embodied in the trial-varying nature of the BOLD response magnitude. Habituation and activation maps are then estimated within the Bayesian framework in a fully unsupervised MCMC procedure. On artificial fMRI datasets, we show that habituation effects can be accurately recovered in activating voxels. (authors)

  4. Effects of different tempers on precipitation hardening of 6000 series aluminium alloys

    Institute of Scientific and Technical Information of China (English)

    LIU Hong; ZHAO Gang; LIU Chun-ming; ZUO Liang

    2007-01-01

    By means of Vickers hardness, mechanical property and formability tests, the effects of different tempers on precipitation hardening of 6000 series aluminium alloys for automotive body sheets were investigated. The results indicate that the short-time pre-aging at 170 ℃ makes for subsequent artificial aging precipitation hardening. With the increase of pre-aging time, the artificial aging hardenability increases. The aging hardening rate reaches the maximum when pre-aging time is up to 10 min, and then it decreases. The short-time pre-aging at 170 ℃ benefits sheets to obtain lower strength under delivery condition and consequently to improve stamping formability of automotive body sheets. The effects of different tempers on precipitation hardening are much more obvious than those of the alloying elements. It is a good treatment schedule to perform pre-aging for 5 min at 170 ℃ right after solution treatment.

  5. Cooling load calculation by the radiant time series method - effect of solar radiation models

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Alexandre M.S. [Universidade Estadual de Maringa (UEM), PR (Brazil)], E-mail: amscosta@uem.br

    2010-07-01

    In this work was analyzed numerically the effect of three different models for solar radiation on the cooling load calculated by the radiant time series' method. The solar radiation models implemented were clear sky, isotropic sky and anisotropic sky. The radiant time series' method (RTS) was proposed by ASHRAE (2001) for replacing the classical methods of cooling load calculation, such as TETD/TA. The method is based on computing the effect of space thermal energy storage on the instantaneous cooling load. The computing is carried out by splitting the heat gain components in convective and radiant parts. Following the radiant part is transformed using time series, which coefficients are a function of the construction type and heat gain (solar or non-solar). The transformed result is added to the convective part, giving the instantaneous cooling load. The method was applied for investigate the influence for an example room. The location used was - 23 degree S and 51 degree W and the day was 21 of January, a typical summer day in the southern hemisphere. The room was composed of two vertical walls with windows exposed to outdoors with azimuth angles equals to west and east directions. The output of the different models of solar radiation for the two walls in terms of direct and diffuse components as well heat gains were investigated. It was verified that the clear sky exhibited the less conservative (higher values) for the direct component of solar radiation, with the opposite trend for the diffuse component. For the heat gain, the clear sky gives the higher values, three times higher for the peek hours than the other models. Both isotropic and anisotropic models predicted similar magnitude for the heat gain. The same behavior was also verified for the cooling load. The effect of room thermal inertia was decreasing the cooling load during the peak hours. On the other hand the higher thermal inertia values are the greater for the non peak hours. The effect

  6. Augmentation of Psychotherapy through Alternative Preconscious Priming: A Case Series Exploring Effects on Residual Symptoms

    Science.gov (United States)

    Zidani, Melha; Audet, Jean-Sébastien; Borgeat, François; Aardema, Frederick; O’Connor, Kieron Philip; Khazaal, Yasser

    2017-01-01

    The current paper describes a case series using a new strategy for facilitating change based on Augmentation of Psychotherapy through Alternative Preconscious Priming (APAP) (1) in the treatment of eight treatment-resistant patients suffering from social phobia or generalized anxiety disorder. The patients had previously only shown a partial response to cognitive behavioral therapy (CBT) despite good treatment adherence. The patients completed APAP using a computerized program, which consisted of three steps during which alternative, more functional thoughts and beliefs relevant to the idiosyncratic difficulties experienced by the patients were formulated. Subsequently, these formulations were recorded and mixed with masking relaxing music, which the patient listened to in a passive state twice daily for 20 min for a period of 8 weeks. This case series aimed to assess the effect and acceptability of APAP using quantitative and qualitative measures administered before, after, and 16 weeks’ posttreatment. Results showed a reduction in dysfunctional idiosyncratic thoughts reported by most patients, as well as mild improvements in anxiety and important improvements in quality of life. APAP could be a valuable addition to CBT by facilitating or enhancing cognitive and symptom change. Further studies are needed to confirm these promising results. PMID:28197107

  7. Modeling Financial Time Series Based on a Market Microstructure Model with Leverage Effect

    Directory of Open Access Journals (Sweden)

    Yanhui Xi

    2016-01-01

    Full Text Available The basic market microstructure model specifies that the price/return innovation and the volatility innovation are independent Gaussian white noise processes. However, the financial leverage effect has been found to be statistically significant in many financial time series. In this paper, a novel market microstructure model with leverage effects is proposed. The model specification assumed a negative correlation in the errors between the price/return innovation and the volatility innovation. With the new representations, a theoretical explanation of leverage effect is provided. Simulated data and daily stock market indices (Shanghai composite index, Shenzhen component index, and Standard and Poor’s 500 Composite index via Bayesian Markov Chain Monte Carlo (MCMC method are used to estimate the leverage market microstructure model. The results verify the effectiveness of the model and its estimation approach proposed in the paper and also indicate that the stock markets have strong leverage effects. Compared with the classical leverage stochastic volatility (SV model in terms of DIC (Deviance Information Criterion, the leverage market microstructure model fits the data better.

  8. Effect of Asymmetrical Edge Disconnection on Equivalent Series Resistance of Metalized Polypropylene Capacitors

    Directory of Open Access Journals (Sweden)

    J. Sivakumar

    2014-01-01

    Full Text Available In order to investigate the effect of asymmetrical partial edge disconnection on the Equivalent Series Resistance (ESR of Metalized polypropylene capacitors an experimental study has been made. Theoretical analysis made using PSPICE simulation package reveals that electrode resistance of individual turn rises from 10 to 30% depending on the location of the turn. This rise is not measureable at all the frequencies as ESR is frequency dependent and it includes resistance due to electrodes and dielectric losses. Metalized polypropylene capacitors were made with partial edge disconnection at one end (asymmetrical with different magnitudes of edge disconnection by masking during the process of zinc spraying. Measurements of ESR have been made in a wide range of frequencies from 20 Hz to 50 MHz and the theoretical results are validated through the experimental data. A short time step stress test was conducted on the capacitors, which can be further developed as a type test to identify the capacitors with partial edge disconnection.

  9. Low-derivative operators of the Standard Model effective field theory via Hilbert series methods

    CERN Document Server

    Lehman, Landon

    2015-01-01

    In this work, we explore an extension of Hilbert series techniques to count operators that include derivatives. For sufficiently low-derivative operators, we find an algorithm that gives the number of invariant operators, properly accounting for redundancies due to the equations of motion and integration by parts. Specifically, the technique can be applied whenever there is only one Lorentz invariant for a given partitioning of derivatives among the fields. At higher numbers of derivatives, equation of motion redundancies can be removed, but the increased number of Lorentz contractions spoils the subtraction of integration by parts redundancies. While restricted, this technique is sufficient to automatically generate the complete set of invariant operators of the Standard Model effective field theory for dimensions 6 and 7 (for arbitrary numbers of flavors). At dimension 8, the algorithm does not automatically generate the complete operator set; however, it suffices for all but five classes of operators. For ...

  10. Priorities in Dealing with Nutrition Problems in Indonesia. Cornell International Nutrition Monograph Series, Number 1 (1974).

    Science.gov (United States)

    Soekirman

    A study of the literature dealing with past and present food and nutrition problems in Indonesia reveals that the problems remain serious. The major nutrition problems are: (1) Protein-Calorie Malnutrition; (2) Vitamin A Deficiency; (3) Nutritional Anemia; and (4) Goitre. These nutrition problems afflict people of all ages, males and females.…

  11. State Defense Force Monograph Series: Mission Growth of the SDF from the Cold War

    Science.gov (United States)

    2009-01-01

    as pre-placed and “walk-in” explosive devices; our critical infrastructure is vulnerable to all forms of interruption and destruction by external...knowledge that the nation was not prepared for Pearl Harbor; it was not prepared for the first attack on the World Trade Center ( WTC ), nor was it prepared...for the subsequent attacks of 9-11 on the WTC and the Pentagon. What will it take to move us from business as usual to a point of realization that

  12. Safety in Individual and Dual Sports. Sports Safety Series. Monograph No. 4.

    Science.gov (United States)

    Borozne, Joseph, Ed.; And Others

    The prevention of injuries and control of hazards in individual and dual sports is outlined. A separate chapter is devoted to each of twelve sports: archery, bowling, equitation, golf, gymnastics, marksmanship, track and field, weight training and weight lifting, fencing, racquet sports, judo, and wrestling. (MM)

  13. The equilibrium theory of inhomogeneous polymers (international series of monographs on physics)

    CERN Document Server

    Fredrickson, Glenn

    2013-01-01

    The Equilibrium Theory of Inhomogeneous Polymers provides an introduction to the field-theoretic methods and computer simulation techniques that are used in the design of structured polymeric fluids. By such methods, the principles that dictate equilibrium self-assembly in systems ranging from block and graft copolymers, to polyelectrolytes, liquid crystalline polymers, and polymer nanocomposites can be established. Building on an introductory discussion of single-polymer statistical mechanics, the book provides a detailed treatment of analytical and numerical techniques for addressing the conformational properties of polymers subjected to spatially-varying potential fields. This problem is shown to be central to the field-theoretic description of interacting polymeric fluids, and models for a number of important polymer systems are elaborated. Chapter 5 serves to unify and expound the topic of self-consistent field theory, which is a collection of analytical and numerical techniques for obtaining solutions o...

  14. Collegiate Aviation Research and Education Solutions to Critical Safety Issues. UNO Aviation Monograph Series. UNOAI Report.

    Science.gov (United States)

    Bowen, Brent, Ed.

    This document contains four papers concerning collegiate aviation research and education solutions to critical safety issues. "Panel Proposal Titled Collegiate Aviation Research and Education Solutions to Critical Safety Issues for the Tim Forte Collegiate Aviation Safety Symposium" (Brent Bowen) presents proposals for panels on the…

  15. Dynamics of the earth's radiation belts and inner magnetosphere (geophysical monograph series)

    CERN Document Server

    2013-01-01

    Dynamics of the Earth's Radiation Belts and Inner Magnetosphere draws together current knowledge of the radiation belts prior to the launch of Radiation Belt Storm Probes (RPSP) and other imminent space missions, making this volume timely and unique. The volume will serve as a useful benchmark at this exciting and pivotal period in radiation belt research in advance of the new discoveries that the RPSP mission will surely bring. Highlights include the following: a review of the current state of the art of radiation belt science; a complete and up-to-date account of the wave-particle interactions that control the dynamical acceleration and loss processes of particles in the Earth's radiation belts and inner magnetosphere; a discussion emphasizing the importance of the cross-energy coupling of the particle populations of the radiation belts, ring current, and plasmasphere in controlling the dynamics of the inner magnetosphe...

  16. Toward a Methodology of Naturalistic Inquiry in Educational Evaluation. CSE Monograph Series in Evaluation, 8.

    Science.gov (United States)

    Guba, Egon G.

    Evaluation is viewed as essential to decision making and social policy development. Since conventional methods have been disappointing or inadequate, naturalistic inquiry (N/I) differs from conventional science in minimizing constraints on antecedent conditions (controls) and on output (dependent variables). N/I is phenomenological rather than…

  17. Developmental Language Disability: Adult Accomplishments of Dyslexic Boys. Hood College Monograph Series, Number 2.

    Science.gov (United States)

    Rawson, Margaret B.

    A longitudinal study was made of 56 boys, a highly homogeneous group from 44 families. All had attended a regular private elementary school for at least 3 years between 1930 and 1937. All were placed in three groups according to their performance on a language learning facility scale. The lowest 20 were rated as dyslexis, with specific…

  18. Psychosocial Rehabilitation and Mental Illness: Views from Africa, India, Asia and Australia. Monograph Series, Number 49.

    Science.gov (United States)

    Anthony, William A., Ed.; Wolkon, George H., Ed.

    1990-01-01

    This special journal "Theme" issue presents a collection of papers reflecting the psychiatric practices and community treatment for persons with severe psychiatric disabilities in Asia, Africa, Australia, and India. Some of the papers were presented at the 1988 meeting of the World Association of Psychosocial Rehabilitation (WAPR) in…

  19. Workforce Skills Development and Engagement in Training through Skill Sets. NCVER Monograph Series 11/2012

    Science.gov (United States)

    Mills, John; Crean, David; Ranshaw, Danielle; Bowman, Kaye

    2012-01-01

    There has been some debate over whether skill sets have the capacity to be part of a more flexible skilling solution, one in which vocational education and training (VET) in Australia is enhanced. This proposition is explored using a case study of agrifood students who were enrolled in TAFE NSW Statement of Attainment in Rural Production Studies…

  20. Professors as Teacher Trainers. Career and Technology Education Monograph Series No. 1.

    Science.gov (United States)

    Stutsman, Galen

    This report is concerned with the responsibilities of professors for teacher training. The quality of high school and post high school business teaching depends upon attitudes toward and understandings of business and the economic system which have been developed in the business courses on the college level. The paper briefly examines the…

  1. Psychosocial Characteristics of Drug-Abusing Women. Services Research Monograph Series.

    Science.gov (United States)

    Burt, Marvin R.; And Others

    In recent years considerable attention has been paid to the status of women as drug abusers and as clients in drug treatment programs. A study of drug abusers' characteristics found a significantly higher history of non-medical psychotherapeutic drug use for females than for males; however, males had a higher prevalence of illicit drug use.…

  2. ASIS Thesaurus of Information Science and Librarianship. ASIS Monograph Series. Second Edition.

    Science.gov (United States)

    Milstead, Jessica L., Ed.

    This thesaurus covers the fields of information science and librarianship to a depth that will adequately support indexing, with coverage of related and peripheral fields as warranted by the strength of their relationship to information science and librarianship. Among the related fields are computer science, linguistics, and behavioral and…

  3. Adolescent Marijuana Abusers and Their Families. Research Monograph Series, No. 40.

    Science.gov (United States)

    Hendin, Herbert; And Others

    Substantial evidence is accumulating which emphasizes the significant role of the family for drug abusing adolescents. To investigate the influence of the family on adolescents (N=17) involved in heavy marihuana use, interviews with family members, case studies of each adolescent, and psychological evaluations were conducted to determine the…

  4. A Year as an Educator in Northwest China. World Education Monograph Series, Number Two.

    Science.gov (United States)

    Elias, Richard F.

    Chinese children must attend school until age 16, and education consists of elementary schools for ages 6-13 and lower middle schools for ages 13-16. While the economic planning of the national government in Beijing (China) dictates what will be emphasized, the school curriculum includes instruction in ideology, Chinese language, calligraphy, fine…

  5. Anaerobic Digestion. Selected Instructional Activities and References. Instructional Resources Monograph Series.

    Science.gov (United States)

    Townsend, Robert D., Comp.

    Focusing specifically on the wastewater treatment process of anaerobic digestion, this document identifies instructional and reference materials for use by professionals in the field in the development and implementation of new programs or in the updating of existing programs. It is designed to help trainers, plant operators, educators, engineers,…

  6. Transforming Teaching and Learning in Urban Schools through Alternative Assessment. Urban Monograph Series.

    Science.gov (United States)

    Winking, Deborah L.; Bond, Linda Ann

    This paper looks at alternative assessment and explores its place in educational reform. It gives a snapshot of alternative assessment in practice, guidelines for establishing it as part of the urban school culture, and resources for additional information. Alternative assessments differ from traditional tests in that they require students to…

  7. Revisiting an open access monograph experiment: measuring citations and tweets 5 years later.

    Science.gov (United States)

    Snijder, Ronald

    2016-01-01

    An experiment run in 2009 could not assess whether making monographs available in open access enhanced scholarly impact. This paper revisits the experiment, drawing on additional citation data and tweets. It attempts to answer the following research question: does open access have a positive influence on the number of citations and tweets a monograph receives, taking into account the influence of scholarly field and language? The correlation between monograph citations and tweets is also investigated. The number of citations and tweets measured in 2014 reveal a slight open access advantage, but the influence of language or subject should also be taken into account. However, Twitter usage and citation behaviour hardly overlap.

  8. Automatic identification and normalization of dosage forms in drug monographs

    Directory of Open Access Journals (Sweden)

    Li Jiao

    2012-02-01

    Full Text Available Abstract Background Each day, millions of health consumers seek drug-related information on the Web. Despite some efforts in linking related resources, drug information is largely scattered in a wide variety of websites of different quality and credibility. Methods As a step toward providing users with integrated access to multiple trustworthy drug resources, we aim to develop a method capable of identifying drug's dosage form information in addition to drug name recognition. We developed rules and patterns for identifying dosage forms from different sections of full-text drug monographs, and subsequently normalized them to standardized RxNorm dosage forms. Results Our method represents a significant improvement compared with a baseline lookup approach, achieving overall macro-averaged Precision of 80%, Recall of 98%, and F-Measure of 85%. Conclusions We successfully developed an automatic approach for drug dosage form identification, which is critical for building links between different drug-related resources.

  9. I. Sleep and development: introduction to the monograph.

    Science.gov (United States)

    El-Sheikh, Mona; Sadeh, Avi

    2015-03-01

    Literature on sleep and child development is growing rapidly in exciting new directions across several disciplines and with this comes a need for guiding conceptual principles and methodological tools. In this introductory chapter, the importance of sleep for child development across multiple domains is highlighted. The aims of this monograph are presented and pertain to the need to consider and integrate theory and research across multiple disciplines and use state-of-the-art methodologies. A developmental ecological systems perspective adapted to sleep illustrates the multiple levels of influence and their importance in the study of child sleep and development. A focal aim is to provide examples of longitudinal studies linking sleep with child development, which are presented in seven chapters of this volume. © 2015 The Society for Research in Child Development, Inc.

  10. A COMPARATIVE STUDY OF SIMULATION AND TIME SERIES MODEL IN QUANTIFYING BULLWHIP EFFECT IN SUPPLY CHAIN

    Directory of Open Access Journals (Sweden)

    T. V. O. Fabson

    2011-11-01

    Full Text Available Bullwhip (or whiplash effect is an observed phenomenon in forecast driven distribution channeland careful management of these effects is of great importance to managers of supply chain.Bullwhip effect refers to situations where orders to the suppliers tend to have larger variance thansales to the buyer (demand distortion and the distortion increases as we move up the supply chain.Due to the fact that demand of customer for product is unstable, business managers must forecast inorder to properly position inventory and other resources. Forecasts are statistically based and in mostcases, are not very accurate. The existence of forecast errors made it necessary for organizations tooften carry an inventory buffer called “safety stock”. Moving up the supply chain from the end userscustomers to raw materials supplier there is a lot of variation in demand that can be observed, whichcall for greater need for safety stock.This study compares the efficacy of simulation and Time Series model in quantifying the bullwhipeffects in supply chain management.

  11. Effect of operating current dependent series resistance on the fill factor of a solar cell

    Energy Technology Data Exchange (ETDEWEB)

    Dadu, Meena; Kapoor, A.; Tripathi, K.N. [Department of Electronic Science, University of Delhi, South Campus, Benito Juarez road, -110 021 New Delhi (India)

    2002-02-01

    The fill factor of a solar cell depends upon the series resistance, reverse saturation current, diode quality factor, operating current and voltage. Since the series resistance itself depends upon the operating current (or voltage), it makes the evaluation of fill factor very complicated. In this paper, we have evaluated the fill factor of a solar cell, taking into account operating current dependence of the series resistance.

  12. Explicit-water theory for the salt-specific effects and Hofmeister series in protein solutions

    Science.gov (United States)

    Kalyuzhnyi, Yuriy V.; Vlachy, Vojko

    2016-06-01

    Effects of addition of salts on stability of aqueous protein solutions are studied theoretically and the results are compared with experimental data. In our approach, all the interacting species, proteins, ions, and water molecules, are accounted for explicitly. Water molecules are modeled as hard spheres with four off-center attractive square-well sites. These sites serve to bind either another water or to solvate the ions or protein charges. The ions are represented as charged hard spheres, and decorated by attractive sites to allow solvation. Spherical proteins simultaneously possess positive and negative groups, represented by charged hard spheres, attached to the surface of the protein. The attractive square-well sites, mimicking the protein-protein van der Waals interaction, are located on the surface of the protein. To obtain numerical results, we utilized the energy route of Wertheim's associative mean spherical approximation. From measurable properties, we choose to calculate the second virial coefficient B2, which is closely related to the tendency of proteins to aggregate and eventually crystalize. Calculations are in agreement with experimental trends: (i) For low concentration of added salt, the alkali halide salts follow the inverse Hofmeister series. (ii) At higher concentration of added salt, the trend is reversed. (iii) When cations are varied, the salts follow the direct Hofmeister series. (iv) In contrast to the colloidal theories, our approach correctly predicts the non-monotonic behavior of B2 upon addition of salts. (v) With respect to anions, the theory predicts for the B2 values to follow different sequences below and above the iso-ionic point, as also confirmed experimentally. (vi) A semi-quantitative agreement between measured and calculated values for the second virial coefficient, as functions of pH of solution and added salt type and concentration, is obtained.

  13. Effects of Paddy Price Support Withdrawal on Malaysian Rice Sector: Time Series Econometric Approach

    Directory of Open Access Journals (Sweden)

    Umar Haruna Suleiman

    2014-07-01

    Full Text Available The study simulated effects of paddy price support withdrawal, as an alternative policy, on key variables namely domestic rice supply, domestic rice demand, net import of rice, area planted to paddy and paddy producer price. Time series data (1980-2012 were collected and analyzed using Autoregressive Distributed lag (ARDL. The long run coefficients or elasticities generated were used in scenarios simulation through appropriate simulation technique. The results show that, on the average, paddy price support withdrawal would affect the rice sector by 2020 in the following ways: 13% decline in domestic rice production; 23% increase in net rice import; area planted to paddy decrease in size by 13%; and, paddy producer price reduce by 20%. However, there was no effect on aggregate rice consumption. Since the country is concern about raising farm income and ensuring rice food security, sustaining the paddy support price is worthwhile policy in order to avoid a decline in paddy producer price (income and surge in import bills.

  14. Time series analyses of the effect of FDA communications on use of prescription weight loss medications.

    Science.gov (United States)

    Block, Jason P; Choudhry, Niteesh K; Carpenter, Daniel P; Fischer, Michael A; Brennan, Troyen A; Tong, Angela Y; Matlin, Olga S; Shrank, William H

    2014-03-01

    To determine the impact of FDA safety communications regarding the weight loss medications sibutramine and orlistat. The 2008 to 2011 pharmacy claims data from CVS Caremark were used to determine the effect of the relevant FDA warnings on (1) use of sibutramine and orlistat, (2) their rates of discontinuation, and (3) substitution to an alternate weight loss medication in the 3-month period following discontinuation. The use of sibutramine, orlistat, or phentermine declined from 45 users per 100,000 Caremark enrollees in May 2008 to 24 users per 100,000 enrollees in December 2010. In the time series analyses of overall use of medications, a very small decline in the trend of use of sibutramine after the FDA communication (0.000002% per month decline after the communication; P 0.1 for both level and trend changes post-warning). Patients discontinuing sibutramine post-communication increased use of phentermine at a rate of 0.004% per month after discontinuation (P = 0.01). From 2008 to 2010, use of prescription weight loss medications was low and declined over time. FDA communications regarding the safety of these medications had limited effect on use. Copyright © 2013 The Obesity Society.

  15. Irradiation Effects Test Series: Test IE-2. Test results report. [PWR

    Energy Technology Data Exchange (ETDEWEB)

    Allison, C. M.; Croucher, D. W.; Ploger, S. A.; Mehner, A. S.

    1977-08-01

    The report describes the results of a test using four 0.97-m long PWR-type fuel rods with differences in diametral gap and cladding irradiation. The objective of this test was to provide information about the effects of these differences on fuel rod behavior during quasi-equilibrium and film boiling operation. The fuel rods were subjected to a series of preconditioning power cycles of less than 30 kW/m. Rod powers were then increased to 68 kW/m at a coolant mass flux of 4900 kg/s-m/sup 2/. After one hour at 68 kW/m, a power-cooling-mismatch sequence was initiated by a flow reduction at constant power. At a flow of 2550 kg/s-m/sup 2/, the onset of film boiling occurred on one rod, Rod IE-011. An additional flow reduction to 2245 kg/s-m/sup 2/ caused the onset of film boiling on the remaining three rods. Data are presented on the behavior of fuel rods during quasiequilibrium and during film boiling operation. The effects of initial gap size, cladding irradiation, rod power cycling, a rapid power increase, and sustained film boiling are discussed. These discussions are based on measured test data, preliminary postirradiation examination results, and comparisons of results with FRAP-T3 computer model calculations.

  16. Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs.

    Science.gov (United States)

    Rook, Jerri M; Abe, Masahito; Cho, Hyekyung P; Nance, Kellie D; Luscombe, Vincent B; Adams, Jeffrey J; Dickerson, Jonathan W; Remke, Daniel H; Garcia-Barrantes, Pedro M; Engers, Darren W; Engers, Julie L; Chang, Sichen; Foster, Jarrett J; Blobaum, Anna L; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W

    2017-01-10

    Both historical clinical and recent preclinical data suggest that the M1 muscarinic acetylcholine receptor is an exciting target for the treatment of Alzheimer's disease and the cognitive and negative symptom clusters in schizophrenia; however, early drug discovery efforts targeting the orthosteric binding site have failed to afford selective M1 activation. Efforts then shifted to focus on selective activation of M1 via either allosteric agonists or positive allosteric modulators (PAMs). While M1 PAMs have robust efficacy in rodent models, some chemotypes can induce cholinergic adverse effects (AEs) that could limit their clinical utility. Here, we report studies aimed at understanding the subtle structural and pharmacological nuances that differentiate efficacy from adverse effect liability within an indole-based series of M1 ago-PAMs. Our data demonstrate that closely related M1 PAMs can display striking differences in their in vivo activities, especially their propensities to induce adverse effects. We report the discovery of a novel PAM in this series that is devoid of observable adverse effect liability. Interestingly, the molecular pharmacology profile of this novel PAM is similar to that of a representative M1 PAM that induces severe AEs. For instance, both compounds are potent ago-PAMs that demonstrate significant interaction with the orthosteric site (either bitopic or negative cooperativity). However, there are subtle differences in efficacies of the compounds at potentiating M1 responses, agonist potencies, and abilities to induce receptor internalization. While these differences may contribute to the differential in vivo profiles of these compounds, the in vitro differences are relatively subtle and highlight the complexities of allosteric modulators and the need to focus on in vivo phenotypic screening to identify safe and effective M1 PAMs.

  17. Calculation of indoor effective dose factors in ORNL phantoms series due to natural radioactivity in building materials.

    Science.gov (United States)

    Krstic, D; Nikezic, D

    2009-10-01

    In this paper the effective dose in the age-dependent ORNL phantoms series, due to naturally occurring radionuclides in building materials, was calculated. The absorbed doses for various organs or human tissues have been calculated. The MCNP-4B computer code was used for this purpose. The effective dose was calculated according to ICRP Publication 74. The obtained values of dose conversion factors for a standard room are: 1.033, 0.752 and 0.0538 nSv h-1 per Bq kg-1 for elements of the U and Th decay series and for the K isotope, respectively. The values of effective dose agreed generally with those found in the literature, although the values estimated here for elements of the U series were higher in some cases.

  18. Three Evidence Based Methods to Compensate for a Lack of Subject Background when Ordering Chemistry Monographs

    Directory of Open Access Journals (Sweden)

    Robert A. Wright

    2008-09-01

    Full Text Available Objective – The aim of this article is to present evidence based methods for the selection of chemistry monographs, particularly for librarians lacking a background in chemistry. These methods will be described in detail, their practical application illustrated, and their efficacy tested by analyzing circulation data.Methods – Two hundred and ninety-five chemistry monographs were selected between 2005 and 2007 using rigorously-applied evidence based methods involving the Library's integrated library system (ILS, Google, and SciFinder Scholar. The average circulation rate of this group of monographs was compared to the average circulation rate of 254 chemistry monographs selected between 2002 and 2004 when the methods were not used or were in an incomplete state of development.Results – Circulations/month were on average 9% greater in the cohort of monographs selected with the rigorously-applied evidence based methods. Further statistical analysis, however, finds that this result can not be attributed to the different application of these methods. Conclusion – The methods discussed in this article appear to provide an evidence base for the selection of chemistry monographs, but their application does not change circulation rates in a statistically significant way. Further research is needed to determine if this lack of statistical significance is real or a product of the organic development and application of these methods over time, making definitive comparisons difficult.

  19. Effects of series elastic compliance on muscle force summation and the rate of force rise.

    Science.gov (United States)

    Mayfield, Dean L; Cresswell, Andrew G; Lichtwark, Glen A

    2016-10-15

    Compliant tendons permit mechanically unfavourable fascicle dynamics during fixed-end contractions. The purpose of this study was to reduce the effective compliance of tendon and investigate how small reductions in active shortening affect twitch kinetics and contractile performance in response to a second stimulus. The series elastic element (SEE) of the human triceps surae (N=15) was effectively stiffened by applying a 55 ms rotation to the ankle, through a range of 5 deg, at the onset of twitch and doublet [interstimulus interval (ISI) of 80 ms] stimulation. Ultrasonography was employed to quantify lateral gastrocnemius and soleus fascicle lengths. Rotation increased twitch torque (40-75%), rate of torque development (RTD; 124-154%) and torque-time integral (TTI; 70-110%) relative to constant-length contractions at the initial and final joint positions, yet caused only modest reductions in shortening amplitude and velocity. The torque contribution of the second pulse increased when stimulation was preceded by rotation, a finding unable to be explained on the basis of fascicle length or SEE stiffness during contraction post-rotation. A further increase in torque contribution was not demonstrated, nor was an increase in doublet TTI, when the second pulse was delivered during rotation and shortly after the initial pulse (ISI of 10 ms). The depressant effect of active shortening on subsequent torque generation suggests that compliant tendons, by affording large length changes, may limit torque summation. Our findings indicate that changes in tendon compliance shown to occur in response to resistance training or unloading are likely sufficient to considerably alter contractile performance, particularly maximal RTD.

  20. Analyzing Group Level Effects with Clustered Data Using Taylor Series Linearization

    Directory of Open Access Journals (Sweden)

    Francis L. Huang

    2014-11-01

    Full Text Available Clustered data (e.g., students within schools are often analyzed in educational research where data are naturally nested. As a consequence, multilevel modeling (MLM has commonly been used to study the contextual or group-level (e.g., school effects on individual outcomes. The current study investigates the use of an alternative procedure to MLM: regression using Taylor series linearization (TSL variance estimation. Despite the name, regressions using TSL are straightforward to conduct, can yield consistent and unbiased estimates and standard errors (given the appropriate conditions, and can be performed using a variety of commercially- and freely-available statistical software. I analyze a subsample of the High School and Beyond (HSB dataset using MLM, regression using TSL, and ordinary least squares regression and compare results. In addition, 12,000 random samples are drawn from the HSB dataset of varying level-one and level-two sample sizes in order to compute biases in standard errors based on the different conditions. Sample R and SAS syntax showing how to run regressions using TSL are provided

  1. Low-derivative operators of the Standard Model effective field theory via Hilbert series methods

    Energy Technology Data Exchange (ETDEWEB)

    Lehman, Landon; Martin, Adam [Department of Physics, University of Notre Dame,Nieuwland Science Hall, Notre Dame, IN 46556 (United States)

    2016-02-12

    In this work, we explore an extension of Hilbert series techniques to count operators that include derivatives. For sufficiently low-derivative operators, we conjecture an algorithm that gives the number of invariant operators, properly accounting for redundancies due to the equations of motion and integration by parts. Specifically, the conjectured technique can be applied whenever there is only one Lorentz invariant for a given partitioning of derivatives among the fields. At higher numbers of derivatives, equation of motion redundancies can be removed, but the increased number of Lorentz contractions spoils the subtraction of integration by parts redundancies. While restricted, this technique is sufficient to automatically recreate the complete set of invariant operators of the Standard Model effective field theory for dimensions 6 and 7 (for arbitrary numbers of flavors). At dimension 8, the algorithm does not automatically generate the complete operator set; however, it suffices for all but five classes of operators. For these remaining classes, there is a well defined procedure to manually determine the number of invariants. Assuming our method is correct, we derive a set of 535 dimension-8 N{sub f}=1 operators.

  2. Effect of Mg, Si and Cu content on the microstructure of dilute 6000 series aluminium alloys

    Energy Technology Data Exchange (ETDEWEB)

    Jaafar, Aiza, E-mail: cnaizza@gmail.com [School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, 14300 Nibong Tebal, Penang (Malaysia); Rahmat, Azmi [School of Materials Engineering, Universiti Malaysia Perlis, Taman Muhibah, 02600 Jejawi, Arau Perlis (Malaysia); Hussain, Zuhailawati [School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, 14300 Nibong Tebal, Penang (Malaysia); Zainol, Ismail [Chemistry Department, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjung Malim, Perak (Malaysia)

    2011-09-01

    Highlights: > The main precipitates formed in the artificially aged dilute alloys are needle-shaped. > The ageing temperature of 100 deg. C is found to be too low to form precipitates. > The number density of precipitates increases with increasing solute contents. > There is a correlation between Mg{sub 2}Si, Si and Cu content and alloys microstructure. > The precipitates kinetics is faster in the less dilute alloys. - Abstract: The effect of Mg, Si and Cu content on the microstructural development during ageing treatment of dilute 6000 series alloys have been investigated using transmission electron microscopy (TEM). Four dilute alloys were used in this study. These alloys were subjected to quenching and artificial ageing at 100 deg. C, 185 deg. C and 300 deg. C. The microstructural developments of the precipitates formed were monitored by TEM. The ageing temperature of 100 deg. C was found to be too low to form precipitates. It was found that needle or rod-shaped precipitates were formed in the alloys after ageing at 185 and 300 deg. C. Prolong ageing up to 1000 h at 300 deg. C resulted in the formation of Mg{sub 2}Si precipitate that coexists with the type of AlFeSi and Si precipitates. The results show a correlation between the Mg{sub 2}Si, Si and Cu content on the microstructure of the four dilute alloys after ageing treatment.

  3. Potential clamp of isolated dialyzed neuron: minimalization of the effect of series resistance.

    Science.gov (United States)

    Stolc, S; Nemcek, V; Boska, D

    1988-06-01

    A modification of the technique of intracellular dialysis of isolated single excitable cells, such as rat spinal ganglion neuron, suitable for potential clamping of its somatic membrane is described. The advantage of the new modification is the substantial reduction of the effect of inherent resistance in series (RS) to the membrane resistance (RM) on precision of potential clamping. This is attained by reversal of cell position in the perfusion pipette resulting in an approximately tenfold reduction in the area of active membrane. The resistance of this area proportionally increased while RS remained unchanged. Hence the error in potential fixation, which is inversely proportional to the ratio RM/RS, is by approximately one order smaller with the new technique than with the original one. An essential step in the new technique is the osmotic expansion of the cell to improve the contact of the cell with the perfusion pipette in the pore and to facilitate disruption of the appropriate part of the membrane. All features and advantages of the technique of intracellular dialysis, such as simplicity, the possibility to easily change ionic composition of media, and/or to apply drugs to any side of the membrane in the same cell, etc., have been maintained.

  4. Rydberg blockade with multivalent atoms: effect of Rydberg series perturbation on van der Waals interactions

    CERN Document Server

    Topcu, Turker

    2015-01-01

    We investigate the effect of series perturbation on the second order dipole-dipole interactions between strontium atoms in $5sns({^1}S_0)$ and $5snp({^1}P_1)$ Rydberg states as a means of engineering long-range interactions between atoms in a way that gives an exceptional level of control over the strength and the sign of the interaction by changing $n$. We utilize experimentally available data to estimate the importance of perturber states at low $n$, and find that van der Waals interaction between two strontium atoms in the $5snp({^1}P_1)$ states shows strong peaks outside the usual hydrogenic $n^{11}$ scaling. We identify this to be the result of the perturbation of $5snd({^1}D_2)$ intermediate states by the $4d^2({^1}D_2)$ and $4dn's({^1}D_2)$ states in the $n<20$ range. This demonstrates that divalent atoms in general present a unique advantage for creating substantially stronger or weaker interaction strengths than those can be achieved using alkali metal atoms due to their highly perturbed spectra t...

  5. A Dynamic Directional Model for Effective Brain Connectivity using Electrocorticographic (ECoG) Time Series.

    Science.gov (United States)

    Zhang, Tingting; Wu, Jingwei; Li, Fan; Caffo, Brian; Boatman-Reich, Dana

    2015-03-01

    We introduce a dynamic directional model (DDM) for studying brain effective connectivity based on intracranial electrocorticographic (ECoG) time series. The DDM consists of two parts: a set of differential equations describing neuronal activity of brain components (state equations), and observation equations linking the underlying neuronal states to observed data. When applied to functional MRI or EEG data, DDMs usually have complex formulations and thus can accommodate only a few regions, due to limitations in spatial resolution and/or temporal resolution of these imaging modalities. In contrast, we formulate our model in the context of ECoG data. The combined high temporal and spatial resolution of ECoG data result in a much simpler DDM, allowing investigation of complex connections between many regions. To identify functionally segregated sub-networks, a form of biologically economical brain networks, we propose the Potts model for the DDM parameters. The neuronal states of brain components are represented by cubic spline bases and the parameters are estimated by minimizing a log-likelihood criterion that combines the state and observation equations. The Potts model is converted to the Potts penalty in the penalized regression approach to achieve sparsity in parameter estimation, for which a fast iterative algorithm is developed. The methods are applied to an auditory ECoG dataset.

  6. Low-derivative operators of the Standard Model effective field theory via Hilbert series methods

    Science.gov (United States)

    Lehman, Landon; Martin, Adam

    2016-02-01

    In this work, we explore an extension of Hilbert series techniques to count operators that include derivatives. For sufficiently low-derivative operators, we conjecture an algorithm that gives the number of invariant operators, properly accounting for redundancies due to the equations of motion and integration by parts. Specifically, the conjectured technique can be applied whenever there is only one Lorentz invariant for a given partitioning of derivatives among the fields. At higher numbers of derivatives, equation of motion redundancies can be removed, but the increased number of Lorentz contractions spoils the subtraction of integration by parts redundancies. While restricted, this technique is sufficient to automatically recreate the complete set of invariant operators of the Standard Model effective field theory for dimensions 6 and 7 (for arbitrary numbers of flavors). At dimension 8, the algorithm does not automatically generate the complete operator set; however, it suffices for all but five classes of operators. For these remaining classes, there is a well defined procedure to manually determine the number of invariants. Assuming our method is correct, we derive a set of 535 dimension-8 N f = 1 operators.

  7. Trend change detection in NDVI time series: Effects of inter-annual variability and methodology

    NARCIS (Netherlands)

    Forkel, M.; Carvalhais, N.; Verbesselt, J.; Mahecha, M.D.; Neigh, C.; Reichstein, M.

    2013-01-01

    Changing trends in ecosystem productivity can be quantified using satellite observations of Normalized Difference Vegetation Index (NDVI). However, the estimation of trends from NDVI time series differs substantially depending on analyzed satellite datase

  8. Trend Change Detection in NDVI Time Series: Effects of Inter-Annual Variability and Methodology

    Science.gov (United States)

    Forkel, Matthias; Carvalhais, Nuno; Verbesselt, Jan; Mahecha, Miguel D.; Neigh, Christopher S.R.; Reichstein, Markus

    2013-01-01

    Changing trends in ecosystem productivity can be quantified using satellite observations of Normalized Difference Vegetation Index (NDVI). However, the estimation of trends from NDVI time series differs substantially depending on analyzed satellite dataset, the corresponding spatiotemporal resolution, and the applied statistical method. Here we compare the performance of a wide range of trend estimation methods and demonstrate that performance decreases with increasing inter-annual variability in the NDVI time series. Trend slope estimates based on annual aggregated time series or based on a seasonal-trend model show better performances than methods that remove the seasonal cycle of the time series. A breakpoint detection analysis reveals that an overestimation of breakpoints in NDVI trends can result in wrong or even opposite trend estimates. Based on our results, we give practical recommendations for the application of trend methods on long-term NDVI time series. Particularly, we apply and compare different methods on NDVI time series in Alaska, where both greening and browning trends have been previously observed. Here, the multi-method uncertainty of NDVI trends is quantified through the application of the different trend estimation methods. Our results indicate that greening NDVI trends in Alaska are more spatially and temporally prevalent than browning trends. We also show that detected breakpoints in NDVI trends tend to coincide with large fires. Overall, our analyses demonstrate that seasonal trend methods need to be improved against inter-annual variability to quantify changing trends in ecosystem productivity with higher accuracy.

  9. THE EFFECT OF DECOMPOSITION METHOD AS DATA PREPROCESSING ON NEURAL NETWORKS MODEL FOR FORECASTING TREND AND SEASONAL TIME SERIES

    Directory of Open Access Journals (Sweden)

    Subanar Subanar

    2006-01-01

    Full Text Available Recently, one of the central topics for the neural networks (NN community is the issue of data preprocessing on the use of NN. In this paper, we will investigate this topic particularly on the effect of Decomposition method as data processing and the use of NN for modeling effectively time series with both trend and seasonal patterns. Limited empirical studies on seasonal time series forecasting with neural networks show that some find neural networks are able to model seasonality directly and prior deseasonalization is not necessary, and others conclude just the opposite. In this research, we study particularly on the effectiveness of data preprocessing, including detrending and deseasonalization by applying Decomposition method on NN modeling and forecasting performance. We use two kinds of data, simulation and real data. Simulation data are examined on multiplicative of trend and seasonality patterns. The results are compared to those obtained from the classical time series model. Our result shows that a combination of detrending and deseasonalization by applying Decomposition method is the effective data preprocessing on the use of NN for forecasting trend and seasonal time series.

  10. Effect of parameter calculation in direct estimation of the Lyapunov exponent in short time series

    Directory of Open Access Journals (Sweden)

    A. M. López Jiménez

    2002-01-01

    Full Text Available The literature about non-linear dynamics offers a few recommendations, which sometimes are divergent, about the criteria to be used in order to select the optimal calculus parameters in the estimation of Lyapunov exponents by direct methods. These few recommendations are circumscribed to the analysis of chaotic systems. We have found no recommendation for the estimation of λ starting from the time series of classic systems. The reason for this is the interest in distinguishing variability due to a chaotic behavior of determinist dynamic systems of variability caused by white noise or linear stochastic processes, and less in the identification of non-linear terms from the analysis of time series. In this study we have centered in the dependence of the Lyapunov exponent, obtained by means of direct estimation, of the initial distance and the time evolution. We have used generated series of chaotic systems and generated series of classic systems with varying complexity. To generate the series we have used the logistic map.

  11. Taylor Series Trajectory Calculations Including Oblateness Effects and Variable Atmospheric Density

    Science.gov (United States)

    Scott, James R.

    2011-01-01

    Taylor series integration is implemented in NASA Glenn's Spacecraft N-body Analysis Program, and compared head-to-head with the code's existing 8th- order Runge-Kutta Fehlberg time integration scheme. This paper focuses on trajectory problems that include oblateness and/or variable atmospheric density. Taylor series is shown to be significantly faster and more accurate for oblateness problems up through a 4x4 field, with speedups ranging from a factor of 2 to 13. For problems with variable atmospheric density, speedups average 24 for atmospheric density alone, and average 1.6 to 8.2 when density and oblateness are combined.

  12. The Effects of the Reverse Current Caused by the Series Compensation on the Current Differential Protection

    Directory of Open Access Journals (Sweden)

    Cui Tang

    2014-01-01

    Full Text Available The series capacitor compensation is one of the key technologies in the EHV and UHV long distance power transmission lines. This paper analyzes the operation characteristics of the main protection combined with the engineering practice when the transmission line overcompensation due to the series compensation system is modified and analyzes the influence of the transition resistance and the system operation mode on the current differential protection. According to the simulation results, it presents countermeasure on improving the sensitivity of differential current protection.

  13. A Unified Framework for Estimating Minimum Detectable Effects for Comparative Short Interrupted Time Series Designs

    Science.gov (United States)

    Price, Cristofer; Unlu, Fatih

    2014-01-01

    The Comparative Short Interrupted Time Series (C-SITS) design is a frequently employed quasi-experimental method, in which the pre- and post-intervention changes observed in the outcome levels of a treatment group is compared with those of a comparison group where the difference between the former and the latter is attributed to the treatment. The…

  14. 324 Effect of Painting Series Package on the Performances of Junior ...

    African Journals Online (AJOL)

    Tracie1

    Test (PASEPET) were used as treatment and Test instruments. ... Painting Series Package should be developed for teaching Cultural and Creative ... Dance, Drama, Fine and Applied arts, Music, Media arts, ... pictorial psychology and concepts, addresses strangeness, ... painting concept on academic and organizations are.

  15. There's alcohol in my soap: Portrayal and effects of alcohol use in a popular television series.

    NARCIS (Netherlands)

    van Hoof, Joris Jasper; de Jong, Menno D.T.; Fennis, B.M.; Gosselt, Jordi Franciscus

    2009-01-01

    Two studies are reported addressing the media influences on adolescents’ alcohol-related attitudes and behaviours. A content analysis was conducted to investigate the prevalence of alcohol portrayal in a Dutch soap series. The coding scheme covered the alcohol consumption per soap character,

  16. The Effect of Divorce on Suicide in Japan: A Time Series Analysis, 1950-1980.

    Science.gov (United States)

    Stack, Steve

    1992-01-01

    Explored relationship between divorce and suicide in Japan. Time series analysis was unable to substantiate divorce-suicide pattern for Japan. Although research did not offer support for relationship between divorce and suicide which Durkheim predicted, it did corroborate Durkheim's general theory of family integration. (Author/NB)

  17. Academic Relationships and Teaching Resources. Fogarty International Center Series on the Teaching of Preventive Medicine, Volume 6.

    Science.gov (United States)

    Clark, Duncan W., Ed.

    The monograph is one of the Fogarty International Center Series on the Teaching of Preventive Medicine, undertaken to: (1) review and evaluate the state of the art of prevention and control of human diseases; (2) identify deficiences in knowledge requiring further research (including analysis of financial resources, preventive techniques, and…

  18. Rigid cohomology over Laurent series fields

    CERN Document Server

    Lazda, Christopher

    2016-01-01

    In this monograph, the authors develop a new theory of p-adic cohomology for varieties over Laurent series fields in positive characteristic, based on Berthelot's theory of rigid cohomology. Many major fundamental properties of these cohomology groups are proven, such as finite dimensionality and cohomological descent, as well as interpretations in terms of Monsky-Washnitzer cohomology and Le Stum's overconvergent site. Applications of this new theory to arithmetic questions, such as l-independence and the weight monodromy conjecture, are also discussed. The construction of these cohomology groups, analogous to the Galois representations associated to varieties over local fields in mixed characteristic, fills a major gap in the study of arithmetic cohomology theories over function fields. By extending the scope of existing methods, the results presented here also serve as a first step towards a more general theory of p-adic cohomology over non-perfect ground fields. Rigid Cohomology over Laurent Series Fields...

  19. Preface to the first monograph: The Fourth Psychiatric Revolution

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2004-05-01

    the one hand, and cautious forays in the neurosciences, adoption and genetic studies on the other ( from where, hopefully, significant leads in understanding the aetiology of major psychiatric disorders must arise. Diagnostic refinement is a necessary step in this direction, as is use of sophisticated technology to aid the process.And yet, we know that psychiatry, its practitioners, and its patients, do not function in a vacuum. They interact with, and are influenced by, a wide range of complex, interlinked, social and interpersonal forces.These forces are often generated by people not directly connected with the medical speciality of psychiatry. They are the policy-planners, governments, political leaders, activists, social thinkers, NGOs, mass media, enlightened public opinion etc. They have marked influence on social thought and action, policy, funding and research. They influence people and societies often in more significant ways than the medical speciality of psychiatry considers healthy for society.We may continue to function in a vacuum and wait for wisdom to dawn. Or, we may establish a dialogue with them and work for wisdom for happen.The second option seems the more productive one.No doubt, there are some psychiatrists comfortable with the biological label. There are others comfortable with the social one. Both these are needed, for they help to further robust enquiry in their respective fields. But what we also probably need is an integration, a synthesis of the mass of evidence that these two fields have produced. The inevitable conclusions drawn at our present state of knowledge based on such integration will give rise to pointers for further research as well as guidelines for policy-planners. Moreover, it will result in an awakened public opinion empowered with knowledge and evidence, its actions enlightened, and unlikely to be swayed or manipulated by unscrupulous forces.The Mens Sana Monographs are meant to further attempts at such a Fourth

  20. Biowaiver monographs for immediate-release solid oral dosage forms: quinine sulfate.

    Science.gov (United States)

    Strauch, Stefanie; Dressman, Jennifer B; Shah, Vinod P; Kopp, Sabine; Polli, James E; Barends, Dirk M

    2012-02-01

    The biowaiver approach permits evaluation of bioequivalence (BE) using a set of laboratory tests, obviating the need for expensive and time-consuming pharmacokinetic BE studies provided that both the active pharmaceutical ingredient and the formulations can meet the specified criteria. In the present monograph, the biowaiver-relevant data including solubility and permeability data, therapeutic use and therapeutic index, pharmacokinetic properties, reported excipient interactions, and BE/bioavailability studies of quinine sulfate are itemized and discussed. Quinine sulfate has borderline solubility characteristics and, on the whole, is highly permeable. Thus, depending on the jurisdiction, it is assigned to Biopharmaceutics Classification System class I or II. Although these characteristics would suggest a low risk of bioinequivalence among oral quinine products, a recent pharmacokinetic study showed bioinequivalence of two products. Even though quinine does not, strictly speaking, fit the definition of a narrow therapeutic index drug, it shows dose-related and, in some cases, irreversible side effects and toxicities at concentrations not far above the therapeutic concentration range. Taking all relevant aspects into consideration, a biowaiver cannot be recommended for new quinine immediate-release multisource products or major post-approval changes of already marketed quinine products, and in such cases, BE should be evaluated using an in vivo BE study.

  1. Clinical roundtable monograph: Unmet needs in the management of chronic myelogenous leukemia.

    Science.gov (United States)

    Jabbour, Elias J; Bixby, Dale; Akard, Luke P

    2012-12-01

    Approximately 5,000 cases of chronic myelogenous leukemia (CML) are diagnosed each year in the United States. The introduction of tyrosine kinase inhibitors (TKIs) has dramatically improved survival time for many CML patients. Current first-line treatment options include imatinib and the second-generation agents nilotinib and dasatinib. Second- and third-line agents include nilotinib, dasatinib, bosutinib, and the new agent ponatinib. Despite the effectiveness of TKIs, some patients develop resistance or intolerance to these agents. A number of mutations of the BCR-ABL gene have been identified and are associated with TKI resistance. Patients may benefit from switching to a second-line TKI, undergoing hematopoietic stem cell transplant, or receiving newly emerging agents. Although early response is associated with improved patient outcome, clinicians lack tests that can determine which patients will benefit from which therapies. To ensure adequate response, patients should be monitored by both polymerase chain reaction and cytogenetic analysis of the bone marrow. This roundtable monograph reviews key unmet needs in patients with CML related to disease management and treatment options.

  2. Towards iconic language for patient records, drug monographs, guidelines and medical search engines.

    Science.gov (United States)

    Lamy, Jean-Baptiste; Duclos, Catherine; Hamek, Saliha; Beuscart-Zéphir, Marie-Catherine; Kerdelhué, Gaetan; Darmoni, Stefan; Favre, Madeleine; Falcoff, Hector; Simon, Christian; Pereira, Suzanne; Serrot, Elisabeth; Mitouard, Thierry; Hardouin, Etienne; Kergosien, Yannick; Venot, Alain

    2010-01-01

    Practicing physicians have limited time for consulting medical knowledge and records. We have previously shown that using icons instead of text to present drug monographs may allow contraindications and adverse effects to be identified more rapidly and more accurately. These findings were based on the use of an iconic language designed for drug knowledge, providing icons for many medical concepts, including diseases, antecedents, drug classes and tests. In this paper, we describe a new project aimed at extending this iconic language, and exploring the possible applications of these icons in medicine. Based on evaluators' comments, focus groups of physicians and opinions of academic, industrial and associative partners, we propose iconic applications related to patient records, for example summarizing patient conditions, searching for specific clinical documents and helping to code structured data. Other applications involve the presentation of clinical practice guidelines and improving the interface of medical search engines. These new applications could use the same iconic language that was designed for drug knowledge, with a few additional items that respect the logic of the language.

  3. Writing about Class and Race Differences and Similarities in Early Childhood Mathematics: The Case of One Monograph

    Science.gov (United States)

    Parks, Amy Noelle

    2015-01-01

    This article reports on a literature review of 49 articles that cited a single monograph East Lansing written in 1981 about early learning in mathematics to make claims of similarity or difference across lines of race and class in early mathematics. The review found that while about two-thirds of the articles cited the monograph to make claims of…

  4. Writing about Class and Race Differences and Similarities in Early Childhood Mathematics: The Case of One Monograph

    Science.gov (United States)

    Parks, Amy Noelle

    2015-01-01

    This article reports on a literature review of 49 articles that cited a single monograph East Lansing written in 1981 about early learning in mathematics to make claims of similarity or difference across lines of race and class in early mathematics. The review found that while about two-thirds of the articles cited the monograph to make claims of…

  5. Access to Basic Education in Ghana: Politics, Policies and Progress. CREATE Pathways to Access. Research Monograph No. 42

    Science.gov (United States)

    Little, Angela W.

    2010-01-01

    This monograph examines the history and politics of educational reform in Ghana. Using data from interviews conducted with senior policy-makers, implementers and researchers, as well as documentary sources, to explore the drivers and inhibitors of change at the political, bureaucratic and grass-roots levels. The monograph explores the nature of…

  6. A monograph assignment as an integrative application of evidence-based medicine and pharmacoeconomic principles.

    Science.gov (United States)

    Law, Anandi V; Jackevicius, Cynthia A; Bounthavong, Mark

    2011-02-10

    To describe the development and assessment of monographs as an assignment to incorporate evidence-based medicine (EBM) and pharmacoeconomic principles into a third-year pharmacoeconomic course. Eight newly FDA-approved drugs were assigned to 16 teams of students, where each drug was assigned to 2 teams. Teams had to research their drug, write a professional monograph, deliver an oral presentation, and answer questions posed by faculty judges. One team was asked to present evidence for inclusion of the drug into a formulary, while another team presented evidence against inclusion. The teams' average score on the written report was 99.1%; on the oral presentation, 92.5%, and on the online quiz given at the end of the presentations, 77%. Monographs are a successful method of incorporating and integrating learning across different concepts, as well as increasing relevance of pharmacoeconomics in the PharmD curriculum.

  7. Effects of dating errors on nonparametric trend analyses of speleothem time series

    Directory of Open Access Journals (Sweden)

    M. Mudelsee

    2012-10-01

    Full Text Available A fundamental problem in paleoclimatology is to take fully into account the various error sources when examining proxy records with quantitative methods of statistical time series analysis. Records from dated climate archives such as speleothems add extra uncertainty from the age determination to the other sources that consist in measurement and proxy errors. This paper examines three stalagmite time series of oxygen isotopic composition (δ18O from two caves in western Germany, the series AH-1 from the Atta Cave and the series Bu1 and Bu4 from the Bunker Cave. These records carry regional information about past changes in winter precipitation and temperature. U/Th and radiocarbon dating reveals that they cover the later part of the Holocene, the past 8.6 thousand years (ka. We analyse centennial- to millennial-scale climate trends by means of nonparametric Gasser–Müller kernel regression. Error bands around fitted trend curves are determined by combining (1 block bootstrap resampling to preserve noise properties (shape, autocorrelation of the δ18O residuals and (2 timescale simulations (models StalAge and iscam. The timescale error influences on centennial- to millennial-scale trend estimation are not excessively large. We find a "mid-Holocene climate double-swing", from warm to cold to warm winter conditions (6.5 ka to 6.0 ka to 5.1 ka, with warm–cold amplitudes of around 0.5‰ δ18O; this finding is documented by all three records with high confidence. We also quantify the Medieval Warm Period (MWP, the Little Ice Age (LIA and the current warmth. Our analyses cannot unequivocally support the conclusion that current regional winter climate is warmer than that during the MWP.

  8. Time Series

    OpenAIRE

    Gil-Alana, L.A.; Moreno, A; Pérez-de-Gracia, F. (Fernando)

    2011-01-01

    The last 20 years have witnessed a considerable increase in the use of time series techniques in econometrics. The articles in this important set have been chosen to illustrate the main themes in time series work as it relates to econometrics. The editor has written a new concise introduction to accompany the articles. Sections covered include: Ad Hoc Forecasting Procedures, ARIMA Modelling, Structural Time Series Models, Unit Roots, Detrending and Non-stationarity, Seasonality, Seasonal Adju...

  9. Effects of Series resistance, Effective Mobility and Output Conductance on Si- NWFET Based on Y-function Technique

    Directory of Open Access Journals (Sweden)

    Habib Muhammad Nazir Ahmad,

    2011-01-01

    Full Text Available This paper deals with a technique that extracts the MOSFET parameter using the Y-function technique, in conjunction with the drain current, the transconductance data and the series resistance (

  10. Pointwise convergence of Fourier series

    CERN Document Server

    Arias de Reyna, Juan

    2002-01-01

    This book contains a detailed exposition of Carleson-Hunt theorem following the proof of Carleson: to this day this is the only one giving better bounds. It points out the motivation of every step in the proof. Thus the Carleson-Hunt theorem becomes accessible to any analyst.The book also contains the first detailed exposition of the fine results of Hunt, Sjölin, Soria, etc on the convergence of Fourier Series. Its final chapters present original material. With both Fefferman's proof and the recent one of Lacey and Thiele in print, it becomes more important than ever to understand and compare these two related proofs with that of Carleson and Hunt. These alternative proofs do not yield all the results of the Carleson-Hunt proof. The intention of this monograph is to make Carleson's proof accessible to a wider audience, and to explain its consequences for the pointwise convergence of Fourier series for functions in spaces near $äcal Lü^1$, filling a well-known gap in the literature.

  11. Effect of pineapple cropping on soil chemical and physical changes in Tha-yang soil series, Petchaburi province

    OpenAIRE

    Isuwan, A.

    2007-01-01

    The experiment was conducted to investigate the effect of pineapple cropping on chemical and physical property changes of Tha-yang soil series, located on Tumbon Nong-ya-plong, Amphor Nong-yaplong,Petchaburi province. The experimental treatments were the different pineapple cropping soil ages arranged in a completely randomized design, consisting of undisturbed soil (year 0) and pineapple croppingsoil ages of 1, 4 and 8 years with 4 replications each. Soil samples were separated according to ...

  12. Effect of alignment changes on socket reaction moments during gait in transfemoral and knee-disarticulation prostheses: Case series

    OpenAIRE

    Kobayashi, Toshiki; Orendurff, Michael S.; Boone, David A.

    2013-01-01

    The alignment of a lower-limb prosthesis is critical to the successful prosthetic fitting and utilization by the wearer. Loads generated by the socket applied to the residual limb while walking are thought to be different in transfemoral and knee-disarticulation prostheses. The aim of this case series was to compare the socket reaction moments between transfemoral and knee-disarticulation prostheses and to investigate the effect of alignment changes on them. Two amputees, one with a transfemo...

  13. ŞTEFANIA CRISTESCU AND THE „MONOGRAPHIC RESEARCH CRISIS”, 1932–1934

    Directory of Open Access Journals (Sweden)

    Professor ZOLTÁN ROSTÁS

    2013-05-01

    Full Text Available This article analyzes the crisis of the monographic research undertaken by the Sociological School from Bucharest (led by Professor Dimitrie Gusti, between 1932–1933. The focus is on the particular perspective offered by one salient member of the group, Ştefania Cristescu-Golopenţia. The internal reason of the “monograph crisis” was the change in status and orientation of the young members of the School, a transformation that – at least in the case of Şt. C.-G. – disturbed her research work, but did not prevent her from carrying out outstanding studies

  14. Harmonization of monographic standards is needed to ensure the quality of Chinese medicinal materials

    Directory of Open Access Journals (Sweden)

    Zhao Sandy

    2009-09-01

    Full Text Available Abstract This article provides an overview on the regulations of Chinese medicinal materials (CMMs in various countries and regions. Harmonization of CMM monographs would provide standards for the quality control of CMM products and play an important role in the modernization and globalization of Chinese medicine. A harmonized regulatory system would improve the quality of CMMs thereby ensuring the safety of the products and assisting Chinese medicine practitioners in their practice. The fast growing demand worldwide for traditional medicines calls for harmonized monographic standards to safeguard the safety and quality of CMM products.

  15. Effective multifractal features of high-frequency price fluctuations time series and l-variability diagrams

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Jeferson de [Laboratorio de Analise de Bacias e Petrofisica, Departamento de Geologia, Universidade Federal do Parana, Centro Politecnico - Jardim das Americas, Caixa Postal 19001, 81531-990 Curitiba-PR (Brazil); Centro Brasileiro de Pesquisas Fisicas, Rua Dr. Xavier Sigaud 150, 22290-180 Rio de Janeiro-RJ (Brazil)], E-mail: jdesouza@ufpr.br; Duarte Queiros, Silvio M. [Centro Brasileiro de Pesquisas Fisicas, Rua Dr. Xavier Sigaud 150, 22290-180 Rio de Janeiro-RJ (Brazil)], E-mail: sdqueiro@googlemail.com

    2009-11-30

    In this manuscript we present a comprehensive study on the multifractal properties of high-frequency price fluctuations and instantaneous volatility of the equities that compose the Dow Jones Industrial Average. The analysis consists about the quantification of the influence of dependence and non-Gaussianity on the multifractal character of financial quantities. Our results point out an equivalent importance of dependence and non-Gaussianity on the multifractality of time series. Moreover, we analyse l-diagrams of price fluctuations. In the latter case, we show that the fractal dimension of these maps is basically independent of the lag between price fluctuations that we assume.

  16. Effect of adalimumab on an enterocutaneous fistula in patients with Crohn's disease: a case series.

    Science.gov (United States)

    Fujiwara, Kaori; Inoue, Takuya; Yorifuji, Naoki; Iguchi, Munetaka; Sakanaka, Taisuke; Narabayashi, Ken; Kakimoto, Kazuki; Nouda, Sadaharu; Okada, Toshihiko; Abe, Yosuke; Takeuchi, Toshihisa; Higuchi, Kazuhide

    2015-01-01

    Crohn's disease (CD) is characterized by transmural inflammation of the gastrointestinal tract, which predisposes patients to the formation of a fistula. The efficacy of adalimumab (ADA) for an enterocutaneous fistula remains unclear. In this report, we present a case series of 3 patients with enterocutaneous fistulizing CD treated with ADA. ADA treatment achieved sustained complete fistula closure in one patient. The other two cases, which failed to achieve fistula closure, had intestinal stenosis and were not receiving concomitant azathioprine. Combination therapy with ADA and azathioprine may be a useful option and an alternative to surgery for enterocutaneous fistulizing CD.

  17. A method to filter out the effect of river stage fluctuation on groundwater level using time series models

    Science.gov (United States)

    Yoon, Heesung; Park, Eungyu; Yoon, Pilsun; Lee, Eunhee; Kim, Gyoo-Bum

    2016-04-01

    A method to filter out the effect of river stage fluctuations on groundwater level was designed using an artificial neural network-based time series model of groundwater level prediction. The designed method was applied to daily groundwater level data near the Gangjeong-Koryeong Barrage in the Nakdong river, South Korea. First, one-step ahead direct prediction time series models were successfully developed for both cases of before and after the barrage construction using past measurement data of rainfall, river stage, and groundwater level as inputs. The correlation coefficient values between observed and predicted data were over 0.97. Based on the direct prediction models, recursive prediction models for the simulation of groundwater level fluctuations were designed. The effect of river stage fluctuation on groundwater level data was filtered out by setting a constant value for river stage inputs of the recursive time series models. The hybrid water table fluctuation method was employed to estimate the groundwater recharge using the filtered data. The calculated ratios of groundwater recharge to precipitation before and after the barrage construction were 11.0% and 4.3%, respectively. It is expected that the proposed method can be a useful tool for groundwater level prediction and recharge estimation in the riverside area.

  18. Child Maltreatment; Types and effects: Series of six cases from a university hospital in Oman

    Directory of Open Access Journals (Sweden)

    Muna Al-Saadoon

    2012-02-01

    Full Text Available Child maltreatment (CM is common worldwide, and can take many forms. It may even endanger the child’s life, especially when younger children are the victims. CM affects the child’s quality of life and consequently leads to long term issues to be dealt with by the child, family and community. This case series discusses six children who have been subjected to CM, and diagnosed by the child protection team of the departments of Child Health and Behavioural Medicine at Sultan Qaboos University Hospital (SQUH, Oman. The aim of this case series is to increase the level of awareness of CM among Oman’s medical professionals and to highlight the difficulties encountered in diagnosing and providing optimal care for these children. Although treatment is provided in Oman’s health care system, it is clear that there are gaps in the existing system which affect the quality of child protection services provided to the children and their families.

  19. EFFECT OF FDI INFLOW ON ECONOMIC GROWTH OF INDIA: A TIME SERIES ANALYSIS

    Directory of Open Access Journals (Sweden)

    Nikhil Kumar Singh

    2012-05-01

    Full Text Available Foreign direct investment (FDI has boomed in post-reform India. Moreover, the composition and type of FDI has changed considerably since India has opened up to world markets depending on various determinants which exist in the environment. This has fuelled high expectations that FDI may serve as a catalyst to higher economic growth. The literature on foreign direct investment (FDI and economic growth generally points to a positive FDI-growth relationship. However, very few studies offer direct tests of causality between the two variables. In theory, economic growth may induce FDI inflow, and FDI may also stimulate economic growth. This paper adds to the literature by analyzing the existence and nature of these causal relationships. This study deals with the trend analysis of Gross Domestic Product (GDP and FDI from 1990-91 to 2010-11 and forecast the growth trend of both variable. It also analyzes the correlation between GDP and FDI. This study also tries to find out the impact of first and second generation FDI reform on GDP of India through regression method. By using time series data and coefficient of correlation analysis, we found that Foreign Direct Investment (FDI is positively affecting the economic growth. The empirical analysis using the time series data from 1990-91 to 2010-11 shows that FDI plays unambiguous role in contributing to economic growth. While the regression analysis reveals that there is no impact of first and second generation reform on GDP of India.

  20. The effect of doping on magnetic properties of (Fe1-xMnx)2P1-ySiy series

    Science.gov (United States)

    Goraus, Jerzy; Hawełek, Lukasz; Włodarczyk, Patryk

    2015-12-01

    In this paper we present results of ab initio calculations for the (Fe1-xMnx)2P1-ySiy series, where we investigate the effect of doping on magnetic properties of these materials. Such compounds, which belong to the Fe2 P class of magnetocaloric materials are now extensively studied, due to their potential applications in magnetic cooling. In the hexagonal Fe2 P-type structure, transition metals occupy two inequivalent Wyckoff positions: 3 f and 3 g. We have shown that the preference of occupation of one site by the particular transition metal leads to different dependence of magnetic properties with respect to the total doping effect.

  1. Working toward a Continuum of Professional Learning Experiences for Teachers of Science and Mathematics. Research Monograph.

    Science.gov (United States)

    Mundry, Susan; Spector, Barbara; Stiles, Katherine; Loucks-Horsley, Susan

    This monograph is the result of a one-year qualitative study conducted by the National Institute for Science Education (NISE) of reform-oriented interventions, structures, and relationships in preservice and inservice education of teachers of science and mathematics. The study investigated 61 initiatives of reform activity involving teachers of…

  2. A monograph of the African Squirrels, with an enumeration of the specimens in the Leyden Museum

    NARCIS (Netherlands)

    Jentink, F.A.

    1882-01-01

    The African Squirrels have never been monographically studied, although a large number of more or less important descriptions of different species have been given, which are to be found in different periodicals. The late Temminck in his »Esquisses zoologiques sur la côte de Guiné. 1853” was the firs

  3. Herbert L. Matthews and the Cuban Story. Journalism Monographs No. 54.

    Science.gov (United States)

    Knudson, Jerry W.

    Herbert L. Matthews, a veteran journalist for the "New York Times," traveled to Cuba in 1957 to interview Fidel Castro, then a revolutionary seeking the overthrow of the Batista regime. This monograph considers the impact of Matthews' newspaper articles about those interviews and of his subsequent articles about the Cuban situation and…

  4. Procedures for Inventorying and Replacing Missing Monographs in a Large Research Library.

    Science.gov (United States)

    Shaughnessy, Thomas W.

    Divided into inventory project procedures for the identification of missing books for future replacement and inventory guidelines for use by subject librarians to determine whether an item should be replaced, this report sets forth very specific procedures for conducting a comprehensive inventory of monographic holdings. They are based on…

  5. Interactive Robotic Aids--One Option for Independent Living: An International Perspective. Monograph Number 37.

    Science.gov (United States)

    Foulds, Richard, Ed.

    The monograph is a collection of papers on the role of robotics in rehabilitation. The first four papers represent contributions from other countries: "Spartacus and Manus: Telethesis Developments in France and the Netherlands" (H. Kwee); "A Potential Application in Early Education and a Possible Role for a Vision System in a Workstation Based…

  6. The Taming of the Press in Sri Lanka. Journalism Monographs Number 39.

    Science.gov (United States)

    Gunaratne, Shelton A.

    This issue of "Journalism Monographs" deals specifically with the state of newspaper journalism in Sri Lanka, formerly the Dominion of Ceylon. The country's literacy rate is about 81 percent. The first section of this article is a general discussion of newspaper journalism in Sri Lanka, examining historical background and such press…

  7. The evaluation of scientific monograph and publisher's role: the spanish project Scholarly Publishers Indicators (SPI

    Directory of Open Access Journals (Sweden)

    Andrea Capaccioni

    2016-05-01

    Full Text Available This paper aims to examine the issue about the quality assessment of scientific monograph and the role of publishers in the field of Humanities and Social Sciences, focusing on the Spanish project Scholarly Publishers Indicators (SPI. This project was born to identify and explore specific quality indicators for scientific books, starting from the opinion of SSH Spanish experts.

  8. Data Matching, Integration, and Interoperability for a Metric Assessment of Monographs

    DEFF Research Database (Denmark)

    Zuccala, Alesia Ann; Cornacchia, Roberto

    2016-01-01

    This paper details a unique data experiment carried out at the University of Amsterdam, Center for Digital Humanities. Data pertaining to monographs were collected from three autonomous resources, the Scopus Journal Index, WorldCat.org and Goodreads, and linked according to unique identifiers...

  9. HPLC method validation for modernization of the tetracycline hydrochloride capsule USP monograph

    Directory of Open Access Journals (Sweden)

    Emad M. Hussien

    2014-12-01

    Full Text Available This paper is a continuation to our previous work aiming at development and validation of a reversed-phase HPLC for modernization of tetracycline-related USP monographs and the USP general chapter . Previous results showed that the method is accurate and precise for the assay of tetracycline hydrochloride and the limit of 4-epianhydrotetracycline impurity in the drug substance and oral suspension monographs. The aim of the current paper is to examine the feasibility of the method for modernization of USP tetracycline hydrochloride capsule monograph. Specificity, linearity, accuracy and precision were examined for tetracycline hydrochloride assay and 4-epianhydrotetracycline limit. The method was linear in the concentration range from 80% to 160% (r>0.9998 of the assay concentration (0.1 mg/mL for tetracycline hydrochloride and from 50% to 150% (r>0.997 of the acceptance criteria specified in tetracycline hydrochloride capsule monograph for 4-epianhydrotetracycline (NMT 3.0%. The recovery at three concentration levels for tetracycline hydrochloride assay was between 99% and 101% and the RSD from six preparations at the concentration 0.1 mg/mL is less than 0.6%. The recovery for 4-epianhydrotetracycline limit procedure over the concentration range from 50% to 150% is between 96% and 102% with RSD less than 5%. The results met the specified acceptance criteria.

  10. Does It Make a Sound: Are Open Access Monographs Discoverable in Library Catalogs?

    Science.gov (United States)

    McCollough, Aaron

    2017-01-01

    This article describes an exploratory study examining the common perception among library-based publishers that open access academic publications (especially monographs) are not readily discoverable in library catalogs. Using titles from the Michigan Publishing imprint, digital culture books, the study provides an empirical basis for evaluating…

  11. Does It Make a Sound: Are Open Access Monographs Discoverable in Library Catalogs?

    Science.gov (United States)

    McCollough, Aaron

    2017-01-01

    This article describes an exploratory study examining the common perception among library-based publishers that open access academic publications (especially monographs) are not readily discoverable in library catalogs. Using titles from the Michigan Publishing imprint, digital culture books, the study provides an empirical basis for evaluating…

  12. Interwoven Lives: Adolescent Mothers and Their Children. Research Monographs in Adolescence.

    Science.gov (United States)

    Whitman, Thomas L.; Borkowski, John G.; Keogh, Deborah A.; Weed, Keri

    This monograph details the Notre Dame Parenting Project, a comprehensive longitudinal study of the lives of adolescent mothers and their children from pregnancy through the first 8 years of life, describing how their respective developmental trajectories are interwoven and linked to the social contexts in which they live. A total of 281…

  13. Education of the Handicapped and Its Implications for Elementary Industrial Arts. ACESIA Monograph 7.

    Science.gov (United States)

    Calder, Clarence R., Jr.; Horvath, Lester J.

    The purpose of this monograph is to illustrate the implications of Public Law 94-142 on public education at the state and local levels. The first section illustrates the importance for all educators to be aware of the administrative design used in this piece of permanent legislation. The second section describes the major provisions of Public Law…

  14. On the rise of Bayesian econometrics after Cowles Foundation monographs 10, 14

    NARCIS (Netherlands)

    Baştürk, N.; Çakmaklı, C.; Ceyhan, S.P.; van Dijk, H.K.

    2014-01-01

    This paper starts with a brief description of the introduction of the likelihood approach in econometrics as presented in Cowles Foundation Monographs 10 and 14. A sketch is given of the criticisms on this approach mainly from the first group of Bayesian econometricians. Publication and citation pat

  15. On the rise of Bayesian econometrics after Cowles Foundation Monographs 10, 14

    NARCIS (Netherlands)

    Baştürk, N.; Çakmak, C.; Pinar Ceyhan, S.; van Dijk, H.K.

    2014-01-01

    This paper starts with a brief description of the introduction of the likelihood approach in econometrics as presented in Cowles Foundation Monographs 10 and 14. A sketch is given of the criticisms on this approach mainly from the first group of Bayesian econometricians. Publication and citation pat

  16. The Self Perception of Male and Female Homosexuals. Criminal Justice Monograph: Vol. 6, No. 3.

    Science.gov (United States)

    Sisson, William Henry, III

    This monograph presents a historical and theoretical review of homosexuality followed by a study of the self-perception of homosexuals. History bears out that homosexuality has always been one aspect of human sexuality and was more prominent in other periods of human history, depending on societal attitudes and mores. At present, many authors…

  17. Making Industrial Education Facilities Accessible to the Physically Disabled. A Professional Monograph.

    Science.gov (United States)

    Shackelford, Ray; Henak, Richard

    This monograph focuses on the design of accessible industrial education facilities for individuals with physical disabilities. In chapter 1 accessibility is defined, and three significant pieces of federal legislation regarding the equality of educational opportunities for special needs populations are discussed. The role of industrial education…

  18. Cuento Therapy. Folktales as a Culturally Sensitive Psychotherapy for Puerto Rican Children. Monograph No. 12.

    Science.gov (United States)

    Constantino, Giuseppe; And Others

    A seven-year project developing and testing cuento therapy, a form of child psychotherapy in which Puerto Rican mothers recount to their children folktales taken from Puerto Rican culture, is described and evaluated in this monograph. Chapter 1 explains how the research presented in later chapters fits into substantially broader patterns of…

  19. News Piracy: Unfair Competition and the Misappropriation Doctrine. Journalism Monographs No. 56.

    Science.gov (United States)

    Sullivan, Paul W.

    Unfair competition is a complex problem affecting all areas of American business, including the communications media. Piracy of material, an alarmingly widespread example of unfair competition, involves legal as well as ethical questions. This monograph uses the historical approach to trace the development of common-law precedent and trends and…

  20. Using intervention time series analyses to assess the effects of imperfectly identifiable natural events: a general method and example

    Directory of Open Access Journals (Sweden)

    Day Carolyn

    2006-04-01

    Full Text Available Abstract Background Intervention time series analysis (ITSA is an important method for analysing the effect of sudden events on time series data. ITSA methods are quasi-experimental in nature and the validity of modelling with these methods depends upon assumptions about the timing of the intervention and the response of the process to it. Method This paper describes how to apply ITSA to analyse the impact of unplanned events on time series when the timing of the event is not accurately known, and so the problems of ITSA methods are magnified by uncertainty in the point of onset of the unplanned intervention. Results The methods are illustrated using the example of the Australian Heroin Shortage of 2001, which provided an opportunity to study the health and social consequences of an abrupt change in heroin availability in an environment of widespread harm reduction measures. Conclusion Application of these methods enables valuable insights about the consequences of unplanned and poorly identified interventions while minimising the risk of spurious results.

  1. Chart Series

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Centers for Medicare and Medicaid Services (CMS) offers several different Chart Series with data on beneficiary health status, spending, operations, and quality...

  2. Case series

    African Journals Online (AJOL)

    abp

    2013-06-20

    Jun 20, 2013 ... Upper cervical spine injuries: a management of a series of 70 cases. El Fatemi ... women, with traffic accidents being the major traumatic cause. .... osteosynthesis is preferred to respect the biomechanics of the cervical spine ...

  3. In-office bleaching effects on the pulp flow and tooth sensitivity – case series

    Directory of Open Access Journals (Sweden)

    Andrés Felipe CARTAGENA

    2015-01-01

    Full Text Available Laser Doppler flowmetry (LDF is a noninvasive method capable of evaluating variations in pulp blood flow (PBF and pulp vitality. This method has thus far not been used to assess changes in blood flow after in-office bleaching. The aim of this case series report was to measure changes in PBF by LDF in the upper central incisor of three patients submitted to in-office bleaching. The buccal surfaces of the upper arch were bleached with a single session of 35% hydrogen peroxide gel with three 15-min applications. The color was recorded using a value-oriented Vita shade guide before in-office bleaching and one week after the procedure. The tooth sensitivity (TS in a verbal scale was reported, and PBF was assessed by LDF before, immediately, and one week after the bleaching session. The lower arch was submitted to dental bleaching but not used for data assessment. A whitening degree of 3 to 4 shade guide units was detected. All participants experienced moderate to considerable TS after the procedure. The PBF readings reduced 20% to 40% immediately after bleaching. One week post-bleaching, TS and PBF were shown to be equal to baseline values. A reversible decrease of PBF was detected immediately after bleaching, which recovered to the baseline values or showed a slight increase sooner than one week post-bleaching. The LDF method allows detection of pulp blood changes in teeth submitted to in-office bleaching, but further studies are still required.

  4. Effect of intraband variability on stable isotope and density time series obtained from banded corals

    Indian Academy of Sciences (India)

    S Chakraborty; R Ramesh; J M Lough

    2000-03-01

    Density, 18O and 13C were measured along two tracks, one close to the central growth axis and the other, ∼20° off the axis, in a coral (Porites lutea) collected from the Stanley Reef, Central Great Barrier Reef, Australia. The 18O variations in the coral are well correlated with sea surface temperature changes. The common variances between the two tracks were about 60% in the 18O, 13C and the skeletal density variations. Part of the noise (40%) could be due to the difficulty of sampling exactly time contemporaneous parts of each band along the two tracks and part of it could be due to genuine intraband variability. In spite of the intraband variability, the time series obtained from the two tracks are similar, indicating that the dominant causative factor for the isotopic variations is external, i.e., the environmental conditions that prevail during the growth of the coral; density band formation does not appear to be directly controlled by the sea surface temperature.

  5. A Case Series on the Effects of Kripalu Yoga for Generalized Anxiety Disorder.

    Science.gov (United States)

    Morgan, Jessica R; Sullivan, Marlysa; Masuda, Akihiko; Tully, Erin; Cohen, Lindsey L; Anderson, Page L

    2016-07-14

    Generalized anxiety disorder (GAD) is a prevalent psychiatric disorder associated with substantial impairment and poor treatment response. Yoga influences processes that are linked to the maintenance of GAD including mindfulness, anxiety, and heart rate variability, but has yet to be evaluated among people with the disorder. The present study is a first step toward documenting the efficacy of yoga for reducing worry among people with GAD using a single-subject AB design case series and daily ratings of worry. Standardized self-report measures of worry, trait anxiety, experiential avoidance, mindfulness, and heart rate variability were assessed pre- and post-intervention. Three participants with primary GAD received eight twice-weekly Kripalu yoga sessions following a baseline data collection period. All participants showed systematic improvement in daily worry ratings on at least one index and all scores on self-reported measures of worry, anxiety, experiential avoidance, and mindfulness changed in the expected direction following yoga (with one or two exceptions). Participants also showed improved heart rate variability during a worry period from pre- to post-intervention. Yoga has the potential to improve the processes linked to GAD and should stimulate further research in this area.

  6. Effectiveness of streamlined admissions to methadone treatment: a simplified time-series analysis.

    Science.gov (United States)

    Dennis, M L; Ingram, P W; Burks, M E; Rachal, J V

    1994-01-01

    Increasing the availability of, and streamlining the admissions process to, methadone treatment have consistently been the focus of national plans to address the acquired immune deficiency syndrome (AIDS) epidemic. This article uses simplified time-series analysis to evaluate one of the first methadone treatment Waiting List Reduction Demonstration Grants. The demonstration grant significantly increased both the number of people requesting intake appointments from 35 to 100 per month and the percentage of kept appointments from 33% to 54%. An additional 100 slots (an entire year's waiting list) were filled in fewer than three months and actually resulted in a net increase in the length of the waiting list. Relative to the preceding two years, new clients during the grant period were significantly more likely to be 41 or older, African-American, unemployed, daily opioid users, daily cocaine users, and dependent on public assistance to finance treatment. Controlling for the source of treatment financing (a case-mix adjustment), there were no significant changes in retention rates. The program's static client capacity rose from 310 prior to the grant to a peak of 449 during the grant, with a leveling to 410 after the grant. Given that it is clearly more humane and less expensive to treat people who want treatment rather than wait for them to commit a crime and be arrested or even executed, this study strongly suggests the need to make more treatment available on demand.

  7. In-office bleaching effects on the pulp flow and tooth sensitivity - case series.

    Science.gov (United States)

    Cartagena, Andrés Felipe; Parreiras, Sibelli Olivieri; Loguercio, Alessandro Dourado; Reis, Alessandra; Campanha, Nara Hellen

    2015-01-01

    Laser Doppler flowmetry (LDF) is a noninvasive method capable of evaluating variations in pulp blood flow (PBF) and pulp vitality. This method has thus far not been used to assess changes in blood flow after in-office bleaching. The aim of this case series report was to measure changes in PBF by LDF in the upper central incisor of three patients submitted to in-office bleaching. The buccal surfaces of the upper arch were bleached with a single session of 35% hydrogen peroxide gel with three 15-min applications. The color was recorded using a value-oriented Vita shade guide before in-office bleaching and one week after the procedure. The tooth sensitivity (TS) in a verbal scale was reported, and PBF was assessed by LDF before, immediately, and one week after the bleaching session. The lower arch was submitted to dental bleaching but not used for data assessment. A whitening degree of 3 to 4 shade guide units was detected. All participants experienced moderate to considerable TS after the procedure. The PBF readings reduced 20% to 40% immediately after bleaching. One week post-bleaching, TS and PBF were shown to be equal to baseline values. A reversible decrease of PBF was detected immediately after bleaching, which recovered to the baseline values or showed a slight increase sooner than one week post-bleaching. The LDF method allows detection of pulp blood changes in teeth submitted to in-office bleaching, but further studies are still required.

  8. THE DEFORMATION EFFECT OF VM SLIDER MULTI COMPLEX MACHINE SERIES ON PRECISION MACHINING

    Directory of Open Access Journals (Sweden)

    Berezhnoy S. B.

    2015-09-01

    Full Text Available The article is devoted to the problems of increasing the economic growth of the Russian Federation, the development of high-tech knowledge-intensive manufacturing industries on the basis of a fundamentally new technological order, new unmanned technologies. The measures to improve the accuracy of manufacturing of complex and large-sized parts. Currently, the technical level of many sectors of the economy is largely determined by the level of production of means of production. The basis of these means is the machine tool industry. On the basis of machine tool development we handle a comprehensive mechanization and automation of production processes in industry, construction, agriculture, transport and other industries. We completed a comprehensive analysis of the errors affecting the manufacturing precision parts. The activities for improving the accuracy of manufacture based on VM 32 multi-machine complex series were proposed. We made the analysis of the cutting forces influence and the cross-sectional shape of the slide on its deformation for various types of processing. We determined the optimal shape of the cross section of the slider to increase stiffness and reduce deformation of the slide in metal cutting

  9. Acute and subacute effects of urban air pollution on cardiopulmonary emergencies and mortality: time series studies in Austrian cities.

    Science.gov (United States)

    Neuberger, Manfred; Moshammer, Hanns; Rabczenko, Daniel

    2013-10-02

    Daily pollution data (collected in Graz over 16 years and in the Linz over 18 years) were used for time series studies (GAM and case-crossover) on the relationship with daily mortality (overall and specific causes of death). Diagnoses of patients who had been transported to hospitals in Linz were also available on a daily basis from eight years for time series analyses of cardiopulmonary emergencies. Increases in air pollutant levels over several days were followed by increases in mortality and the observed effects increased with the length of the exposure window considered, up to a maximum of 15 days. These mortality changes in Graz and Linz showed similar patterns like the ones found before in Vienna. A significant association of mortality could be demonstrated with NO2, PM2.5 and PM10 even in summer, when concentrations are lower and mainly related to motor traffic. Cardiorespiratory ambulance transports increased with NO2/PM2.5/PM10 by 2.0/6.1/1.7% per 10 µg/m³ on the same day. Monitoring of NO2 (related to motor traffic) and fine particulates at urban background stations predicts acute effects on cardiopulmonary emergencies and extended effects on cardiopulmonary mortality. Both components of urban air pollution are indicators of acute cardiopulmonary health risks, which need to be monitored and reduced, even below current standards.

  10. Time series analysis of the effects of refuse collection on recycling: Taiwan's "Keep Trash Off the Ground" measure.

    Science.gov (United States)

    Chao, Yu-Long

    2008-01-01

    The state of recycling in Taiwan has seen significant achievements due to various recycling policies implemented by environmental agencies in recent years. These policies include the "Keep Trash Off the Ground" (KTOG) measure, the "Four-in-One Recycling Plan", the per-bag trash collection fee and mandatory garbage sorting. An important question worthy of study is which of these policies has had a more pervasive and critical impact on the outcome of recycling. For example, there is evidence that the KTOG measure made it more convenient for people to begin recycling. This study therefore first analyzed the monthly data over the past decade on the amounts of recyclables in Taiwan's three major cities. By examining time series plots and employing an analysis of the time series intervention model, we can better understand the extent of the effects of the KTOG measure on these cities' amounts of recyclables. The same effects were also analyzed for the mandatory garbage sorting policy and the per-bag trash collection fee. Results show that the KTOG measure, essentially a change in refuse collection practice, presented consistent and significant effects on these cities' amounts of recyclables. It is suggested that the key to improving participation in a recycling program in waste management is for techniques to be tailored to actual settings in a way that facilitates citizen cooperation.

  11. Acute and Subacute Effects of Urban Air Pollution on Cardiopulmonary Emergencies and Mortality: Time Series Studies in Austrian Cities

    Directory of Open Access Journals (Sweden)

    Daniel Rabczenko

    2013-10-01

    Full Text Available Daily pollution data (collected in Graz over 16 years and in the Linz over 18 years were used for time series studies (GAM and case-crossover on the relationship with daily mortality (overall and specific causes of death. Diagnoses of patients who had been transported to hospitals in Linz were also available on a daily basis from eight years for time series analyses of cardiopulmonary emergencies. Increases in air pollutant levels over several days were followed by increases in mortality and the observed effects increased with the length of the exposure window considered, up to a maximum of 15 days. These mortality changes in Graz and Linz showed similar patterns like the ones found before in Vienna. A significant association of mortality could be demonstrated with NO2, PM2.5 and PM10 even in summer, when concentrations are lower and mainly related to motor traffic. Cardiorespiratory ambulance transports increased with NO2/PM2.5/PM10 by 2.0/6.1/1.7% per 10 µg/m³ on the same day. Monitoring of NO2 (related to motor traffic and fine particulates at urban background stations predicts acute effects on cardiopulmonary emergencies and extended effects on cardiopulmonary mortality. Both components of urban air pollution are indicators of acute cardiopulmonary health risks, which need to be monitored and reduced, even below current standards.

  12. A monograph of the freshwater Bryozoa-Phylactolaemata

    NARCIS (Netherlands)

    Lacourt, A.W.

    1968-01-01

    1. This paper presents the taxonomy of the Bryozoa Phylactolaemata. The group is found to contain a number of series. The present classification reveals that a number of specific names are synonyms. 2. The evolution of the group is described on the basis of the development of the zoarium and the

  13. Reduction of Over Line Current in Power System from Short Circuit Effect Using Static Synchronous Series Compensator

    Directory of Open Access Journals (Sweden)

    Prechanon Kumkratug

    2011-01-01

    Full Text Available Problem statement: One of the major problems in power system is the over line current from short circuit effect. It may cause in the electrical apparatus outages. Approach: Static Synchronous Series Compensator (SSSC is a power electronic based device that has the capability of controlling the line current. This study applies the SSSC to decrease the over line current in power system during dynamic state. To verify the effect of the SSSC on over line current reduction, the mathematical model of power system equipped with a SSSC is presented. The variation curve of line current of the faulted system with without and with a SSSC is tested and compared in various cases. Results: The line current of the system without a SSSC is continuously oscillation and the maximum value is much more than the system with a SSSC. Conclusion: SSSC can decrease over line current in power system from short circuit effect.

  14. MEL-N16: A Series of Novel Endomorphin Analogs with Good Analgesic Activity and a Favorable Side Effect Profile.

    Science.gov (United States)

    Liu, Xin; Zhao, Long; Wang, Yuan; Zhou, Jingjing; Wang, Dan; Zhang, Yixin; Zhang, Xianghui; Wang, Zhaojuan; Yang, Dongxu; Mou, Lingyun; Wang, Rui

    2017-08-10

    Opioid peptides are neuromodulators that bind to opioid receptors and reduce pain sensitivity. Endomorphins are among the most active endogenous opioid peptides, and they have good affinity and selectivity toward the μ opioid receptor. However, their clinical usage is hindered by their inability to cross the blood-brain barrier and their poor in vivo activity after peripheral injection. In order to overcome these defects, we have designed and synthesized a series of novel endomorphin analogs with multiple site modifications. Radioligand binding, cAMP accumulation, and β-arrestin-2 recruitment assays were employed to determine the activity of synthesized endomorphin analogs toward opioid receptors. The blood-brain barrier permeability and antinociceptive effect of these analogs were determined in several rodent models of acute and persistent pain. In addition, the side effects of the analogs were examined. The radioligand binding assay and functional activity examination indicated that the MEL-N16 series of compounds were more active agonists against μ opioid receptor than were the parent peptides. Notably, the analogs displayed biased downstream signaling toward G-protein pathways over β-arrestin-2 recruitment. The analogs showed highly potent antinociceptive effects in the tested nociceptive models. In comparison with endomorphins, the synthesized analogs were better able to penetrate the blood-brain barrier and exerted their pain regulatory activity in the central nervous system after peripheral injection. These analogs also have lower tendency to cause side effects than morphine does at similar or equal antinociceptive doses. The MEL-N16 compounds have highly potent and efficacious analgesic effects in various pain models with a favorable side effect profile.

  15. Estimation of Effect Size from a Series of Experiments Involving Paired Comparisons.

    Science.gov (United States)

    Gibbons, Robert D.; And Others

    1993-01-01

    A distribution theory is derived for a G. V. Glass-type (1976) estimator of effect size from studies involving paired comparisons. The possibility of combining effect sizes from studies involving a mixture of related and unrelated samples is also explored. Resulting estimates are illustrated using data from previous psychiatric research. (SLD)

  16. Lagged PM2.5 effects in mortality time series: Critical impact of covariate model

    Science.gov (United States)

    The two most common approaches to modeling the effects of air pollution on mortality are the Harvard and the Johns Hopkins (NMMAPS) approaches. These two approaches, which use different sets of covariates, result in dissimilar estimates of the effect of lagged fine particulate ma...

  17. A THEORY OF LEADERSHIP EFFECTIVENESS. MCGRAW-HILL SERIES IN MANAGEMENT.

    Science.gov (United States)

    FIEDLER, FRED E.

    CENTRAL TO THE THEORY OF LEADERSHIP EFFECTIVENESS OUTLINED HERE IS A CONTINGENCY MODEL, ACCORDING TO WHICH GROUP EFFECTIVENESS DEPENDS ON INTERACTION BETWEEN LEADERSHIP STYLES AND THE DEGREE TO WHICH SITUATIONS ENABLE LEADERS TO EXERT INFLUENCE. THE THEORY PREDICTS THAT A TASK-ORIENTED STYLE WILL BE THE BEST STYLE IN FAVORABLE LEADERSHIP…

  18. Manual on Cost-Effectiveness of Training Modalities in Population Education. Population Education Programme Service Series.

    Science.gov (United States)

    United Nations Educational, Scientific and Cultural Organization, Bangkok (Thailand). Principal Regional Office for Asia and the Pacific.

    This manual is the result of a regional training workshop on the cost-effectiveness of different training strategies in population education by Unesco in Kathmandu, Nepal, June 1-8, 1987. The purpose of the manual is to enable project staff to initiate studies to determine cost-effective training strategies in population growth control education.…

  19. Beyond the Tower: Concepts and Models for Service-Learning in Philosophy. AAHE's Series on Service-Learning in the Disciplines.

    Science.gov (United States)

    Lisman, C. David, Ed.; Harvey, Irene E., Ed.

    This volume is part of a series of 18 monographs service learning and the academic disciplines. This collection focuses on the use of service learning as an approach to teaching and learning in philosophy. After a Foreword by David A. Hoekema and an Introduction by C. David Lisman, chapters in Part 1, "Service-Learning as a Mode of…

  20. Construyendo Puentes (Building Bridges): Concepts and Models for Service-Learning in Spanish. AAHE's Series on Service-Learning in the Disciplines.

    Science.gov (United States)

    Hellebrandt, Josef, Ed.; Varona, Lucia T., Ed.

    This volume is part of a series of 18 monographs on service learning and the academic disciplines. It is designed to help teachers, administrators, and students realize the potential of service learning in Spanish. Following a Foreword by Carmen Chaves Tesser and an Introduction by Josef Hellebrandt and Lucia T. Varona, the four essays in Part 1,…

  1. Beneficial effect of acupuncture in the management of anxiety related to dental treatment: a set of case series

    DEFF Research Database (Denmark)

    Rosted, P; Bundgaard, M; Gordon, S

    2010-01-01

    BACKGROUND: Anxiety related to dental treatment is a common phenomenon that has a significant impact on the provision of appropriate dental care. The aim of this case series was to examine the effect of acupuncture given prior to dental treatment on the level of anxiety. METHODS: Eight dentists...... a median BAI score of 26.5 at baseline. The BAI score was assessed before and after the acupuncture treatment. All patients received acupuncture treatment for 5 min prior to the planned dental treatment using the points GV20 and EX6. RESULTS: There was a significant reduction in median value of BAI scores...... after treatment with acupuncture (26.5 reduced to 11.5; pacupuncture treatment. Previously this had only been possible in six cases. CONCLUSION: Acupuncture prior to dental treatment has a beneficial effect...

  2. Beneficial effect of acupuncture in the management of anxiety related to dental treatment: a set of case series

    DEFF Research Database (Denmark)

    Rosted, P; Bundgaard, M; Gordon, S

    2010-01-01

    BACKGROUND: Anxiety related to dental treatment is a common phenomenon that has a significant impact on the provision of appropriate dental care. The aim of this case series was to examine the effect of acupuncture given prior to dental treatment on the level of anxiety. METHODS: Eight dentists...... a median BAI score of 26.5 at baseline. The BAI score was assessed before and after the acupuncture treatment. All patients received acupuncture treatment for 5 min prior to the planned dental treatment using the points GV20 and EX6. RESULTS: There was a significant reduction in median value of BAI scores...... after treatment with acupuncture (26.5 reduced to 11.5; pacupuncture treatment. Previously this had only been possible in six cases. CONCLUSION: Acupuncture prior to dental treatment has a beneficial effect...

  3. [The assessment of no adverse effect doses for plant populations chronically exposed to radionuclides of uranium and thorium decay series].

    Science.gov (United States)

    Evseeva, T I; Maĭstrenko, T A; Belykh, E S; Geras'kin, S A

    2010-01-01

    Dose rates cause no adverse effects on natural populations of Pinus sylvestris L. and Vicia cracca L. inhabiting territories contaminated by uranium mill tailings and radium production wastes (Vodny settlement, Komi Republic) were determined. A significant increase in embryonic lethal mutation frequency in V. cracca legumes and decrease in seedlings survival rate as compared with control values were registered at dose rate equal to 1.67 mGy/day, that is 280 times higher than the one calculated for the reference site. The adverse effects in P. sylvestris expressed in increased frequency of chromosome aberrations in meristematic root tips and decreased reproductive capacity of seeds were determined at absorbed dose rate equal to 0.083 mGy/day. Data obtained show that the decrease in plant reproductive capacity in case of chronic exposure of radionuclides of uranium and thorium decay series can observe at lower weighted absorbed dose rates than in case of environmental contamination by artificial radionuclides.

  4. SERI Wind Energy Program

    Energy Technology Data Exchange (ETDEWEB)

    Noun, R. J.

    1983-06-01

    The SERI Wind Energy Program manages the areas or innovative research, wind systems analysis, and environmental compatibility for the U.S. Department of Energy. Since 1978, SERI wind program staff have conducted in-house aerodynamic and engineering analyses of novel concepts for wind energy conversion and have managed over 20 subcontracts to determine technical feasibility; the most promising of these concepts is the passive blade cyclic pitch control project. In the area of systems analysis, the SERI program has analyzed the impact of intermittent generation on the reliability of electric utility systems using standard utility planning models. SERI has also conducted methodology assessments. Environmental issues related to television interference and acoustic noise from large wind turbines have been addressed. SERI has identified the causes, effects, and potential control of acoustic noise emissions from large wind turbines.

  5. The Combined Release and Radiation Effects Satellite (CRRES) program: A unique series of scientific experiments

    Science.gov (United States)

    Reasoner, David L.; McCook, Morgan W.; Vaughan, William W.

    The Defense Department and NASA have joined in a program to study the space environment which surrounds the earth and the effects of space radiation on modern satellite electronic systems. The Combined Release and Radiation Effects Satellite (CRRES) will carry an array of active experiments including chemical releases and a complement of sophisticated scientific instruments to accomplish these objectives. Other chemical release active experiments will be performed with sub-orbital rocket probes. The chemical releases will 'paint' the magnetic and electric fields of earthspace with clouds of glowing ions. Earthspace will be a laboratory, and the releases will be studied with an extensive network of ground-, aircraft-, and satellite-based diagnostic instruments. Some of the topics discussed include the following: the effects of earthspace; the need for active experiments; types of chemical releases; the CRRES program schedule; international support and coordinated studies; photographing chemical releases; information on locating chemical releases for observation by the amateur; and CRRES as a program.

  6. Student Outcomes Assessment Plan. Pima County Community College District Institutional Effectiveness Series: 5.

    Science.gov (United States)

    Pima County Community Coll. District, AZ.

    The Student Outcomes Assessment Program (SOAP) at Pima Community College (PCC) in Arizona has six major components: (1) the use of success indicators to assess the college's success in achieving its mission; (2) a classroom assessment mini-grant program designed to support faculty research with a direct effect on learning; (3) the use of general…

  7. [Stimulating effect of triphenylmethane series dyes on growth of Escherichia coli bacteria].

    Science.gov (United States)

    Bagramian, K A; Panosian, G A; Trchunian, A A

    1998-01-01

    The stimulating effect of a dye of the triphenylmethane group (fast green) applied at low concentrations (10(-4)%) in the presence of toluene on the specific growth rate of bacteria was found. The cell size did not change during batch cultivation. However, the cell dry weight and zeta-potential increased sharply.

  8. Time-series analysis on effect of air pollution on stroke mortality in Tianjin

    Institute of Scientific and Technical Information of China (English)

    王德征

    2013-01-01

    Objective To investigate the effect of air pollution on stroke mortality in Tianjin,China,and to provide a basis for stroke control and prevention. Methods Total data of mortality surveillance were collected by Tianjin Centers for Disease Control and Prevention.

  9. Assessment of the dynamics of atrial signals and local atrial period series during atrial fibrillation: effects of isoproterenol administration

    Directory of Open Access Journals (Sweden)

    Mantica Massimo

    2004-10-01

    Full Text Available Abstract Background The autonomic nervous system (ANS plays an important role in the genesis and maintenance of atrial fibrillation (AF, but quantification of its electrophysiologic effects is extremely complex and difficult. Aim of the study was to evaluate the capability of linear and non-linear indexes to capture the fine changing dynamics of atrial signals and local atrial period (LAP series during adrenergic activation induced by isoproterenol (a sympathomimetic drug infusion. Methods Nine patients with paroxysmal or persistent AF (aged 60 ± 6 underwent electrophysiological study in which isoproterenol was administered to patients. Atrial electrograms were acquired during i sinus rhythm (SR; ii sinus rhythm during isoproterenol (SRISO administration; iii atrial fibrillation (AF and iv atrial fibrillation during isoproterenol (AFISO administration. The level of organization between two electrograms was assessed by the synchronization index (S, whereas the degree of recurrence of a pattern in a signal was defined by the regularity index (R. In addition, the level of predictability (LP and regularity of LAP series were computed. Results LAP series analysis shows a reduction of both LP and R index during isoproterenol infusion in SR and AF (RSR = 0.75 ± 0.07 RSRISO = 0.69 ± 0.10, p AF = 0.31 ± 0.08 RAFISO = 0.26 ± 0.09, p SR = 99.99 ± 0.001 LPSRISO = 99.97 ± 0.03, p AF = 69.46 ± 21.55 LPAFISO = 55 ± 24.75; p SR = 0.49 ± 0.08 RSRISO = 0.46 ± 0.09 p AF = 0.29 ± 0.09 RAFISO = 0.28 ± 0.08 n.s.. Conclusions The proposed parameters succeeded in discriminating the subtle changes due to isoproterenol infusion during both the rhythms especially when considering LAP series analysis. The reduced value of analyzed parameters after isoproterenol administration could reflect an important pro-arrhythmic influence of adrenergic activation on favoring maintenance of AF.

  10. Effects of sodium bicarbonate ingestion on performance and perceptual responses in a laboratory-simulated BMX cycling qualification series.

    Science.gov (United States)

    Zabala, Mikel; Requena, Bernardo; Sánchez-Muñoz, Cristóbal; González-Badillo, Juan José; García, Inmaculada; Oöpik, Vahur; Pääsuke, Mati

    2008-09-01

    The objective of this study was to examine the effect of sodium bicarbonate (NaHCO3-) ingestion on performance and perceptual responses in a laboratory-simulated bicycle motocross (BMX) qualification series. Nine elite BMX riders volunteered to participate in this study. After familiarization, subjects undertook two trials involving repeated sprints (3 x Wingate tests [WTs] separated by 30 minutes of recovery; WT1, WT2, WT3). Ninety minutes before each trial, subjects ingested either NaHCO3- or placebo in a counterbalanced, randomly assigned, double-blind manner. Each trial was separated by 4 days. Performance variables of peak power, mean power, time to peak power, and fatigue index were calculated for each sprint. Ratings of perceived exertion were obtained after each sprint, and ratings of perceived readiness were obtained before each sprint. No significant differences were observed in performance variables between successive sprints or between trials. For the NaHCO3- trial, peak blood lactate during recovery was greater after WT2 (p BMX qualification series, possibly because of the short duration of each effort and the long recovery time used between the three WTs. On the contrary, NaHCO3- ingestion improved perceived readiness before each WT.

  11. Effects of mandating seatbelt use: a series of surveys on compliance in Michigan.

    Science.gov (United States)

    Wagenaar, A C; Wiviott, M B

    1986-01-01

    Although proper use of automobile seatbelts reduces risk of serious injury or death in traffic crashes by 30 to 50 percent, seatbelt use remains low. Recently, several States have passed laws requiring the use of seatbelts. Michigan implemented such a law July 1, 1985. Direct-observation surveys of a probability sample of motorists throughout the State were conducted before the law was passed, after passage but before implementation, immediately after the law took effect, and 5 months after implementation. The results showed a significant increase in the use of restraints from 19.8 percent before the law was passed to 58.4 percent immediately after it took effect. A restraint use survey conducted in December 1985, 5 months after implementation, measured the use of restraints at 43.0 percent. Despite that decline, belt use was 117 percent higher than the 19.8 percent measured before passage of the law mandating the use of seatbelts. PMID:3094082

  12. The Development of Monograph with 3-Dimentional Illustrations Titled “Augmented Chemistry: Hydrocarbon” as Learning Enrichment Materials

    Science.gov (United States)

    Ernawati, D.; Ikhsan, J.

    2017-02-01

    The development of 3D technology provides more advantages in education sectors. In chemistry, the 3D technology makes chemistry objects look more tangible. This research developed a monograph titled “Augmented Chemistry: Hydrocarbon” as learning enrichment materials. The development model consisted of 5 steps, which were the adaptation of the ADDIE model. The 3D objects of chemistry were built using the computer applications of Chem Sketch, and Google Sketch Up with AR Plugin. The 3D objects were displayed by relevant markers on the texts of the monograph from which the visualizations of the 3D objects appeared when they were captured by digital camera of laptop or smartphone, and were possibly viewed with free-rotation. Not only were 3D chemistry objects included in the monograph, but also graphics, videos, audios, and animations, which facilitated more fun learning for readers of the monograph. After the reviews by the experts of subject matter, of media, of instruction, and by peers, the monograph was revised, and then rated by chemistry teachers. The analysis of the data showed that the monograph titled “Augmented Chemistry: Hydrocarbon” was in the criteria of very good for the enrichment materials of Chemistry learning.

  13. Statin-Associated Muscle-Related Adverse Effects: A Case Series of 354 Patients

    Science.gov (United States)

    Cham, Stephanie; Evans, Marcella A.; Denenberg, Julie O.; Golomb, Beatrice A.

    2016-01-01

    Study Objective To characterize the properties and natural history of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin)-associated muscle-related adverse effects (MAEs). Design Patient-targeted postmarketing adverse-effect surveillance approach coupling survey design with an open-ended narrative. Setting University-affiliated health care system. Subjects Three hundred fifty-four patients (age range 34–86 yrs) who self-reported muscle-related problems associated with statin therapy. Measurements and Main Results Patients with perceived statin-associated MAEs completed a survey assessing statin drugs and dosages; characteristics of the MAEs; time course of onset, resolution, or recurrence; and impact on quality of life (QOL). Cases were assessed for putative drug adverse-effect causality by using the Naranjo adverse drug reaction probability scale criteria and were evaluated for inclusion in groups for which mortality benefit with statins has been shown. Patients reported muscle pain (93%), fatigue (88%), and weakness (85%). Three hundred patients (85%) met literature criteria for probable or definite drug adverse-effect causality. Ninety-four percent of atorvastatin usages (240/255) generated MAEs versus 61% of lovastatin usages (38/62, pstatins reproduced MAEs in 100% of 39 rechallenges versus 73% (29/40) with lower potency rechallenges (pstatin initiation varied (median 14 wks); some MAEs occurred after long-term symptom-free use. Recurrence with rechallenge had a significantly shorter latency to onset (median 2 wks). The MAEs adversely affected all assessed functional and QOL domains. Most patients with probable or definite MAEs were in categories for which available randomized controlled trial evidence shows no trend to all-cause mortality benefit with statin therapy. Conclusion This study complements available information on the properties and natural history of statin-associated MAEs, affirming dose dependence and strong QOL impact. The data

  14. EFFECT OF POLITICAL RISK SHOCKS ON TOURISM REVENUE IN SOUTH AFRICA: TIME SERIES ANALYSIS

    OpenAIRE

    Muzindutsi, Paul-Francois; Manaliyo, Jean Claude

    2016-01-01

    Although political risk has an impact on all types of businesses, political risk affects tourism business performance in terms of tourist arrivals and tourism revenue because tourists are very sensitive to political risk in host countries. This study analysed the effect of political risk on revenue from the tourism industry in South Africa. The sample period of 108 months from January 2007 to December 2015 was used based on the availability of data. The political risk were measured by the cou...

  15. Arrangement and processing of monographic publications in youth sections of public libraries

    Directory of Open Access Journals (Sweden)

    Mateja Ločniškar-Fidler

    2006-01-01

    Full Text Available A systematic and transparent layout of library material on book shelves of public libraries is one of the essential conditions for successful viewing and searching of materials. The research tried to determine the contemporary classification system of library material for the youth. The data needed for the research was gathered and analyzed by a questionnaire completed by five randomly selected central public libraries. Special collections, arrangement and classification of certain fiction and specialized monographic publications for infants, teenagers and adolescents were analyzed. It was of our interest to observe whether the libraries assign the elements of a call number - which are evident on the library material and in online catalogs – according to standards and current instructions. The article also focuses on the unity and differences of the technical processing, and on color and/or image of labels which additionally explain the classification and the contents of the monographic publications for the youth.

  16. Non-European traditional herbal medicines in Europe: a community herbal monograph perspective.

    Science.gov (United States)

    Qu, Liping; Zou, Wenjun; Zhou, Zhenxiang; Zhang, Tingmo; Greef, JanVander; Wang, Mei

    2014-10-28

    The European Directive 2004/24/EC introducing a simplified registration procedure for traditional herbal medicinal products, plays an important role in harmonising the current legislation framework for all herbal medicinal products in the European Union (EU). Although substantial achievements have been made under the new scheme, only a limited number of herbal medicinal products from non-European traditions commonly used in Europe have been registered. Therefore, identification of the obstacles, and determination of appropriate means to overcome the major challenges in the registration of non-European traditional herbal medicinal products are of critical importance for the EU herbal medicinal product market. The primary aims of this study were to understand the key issues and obstacles to registration of non-European traditional herbal medicinal products within the EU. The findings may identify the need for more attention on the Community herbal monographs elaborated by the Herbal Medicinal Products Committee (HMPC), as well as further evidence based scientific research on non-European herbal substances/preparations by the scientific community. A systematic evaluation of the herbal substances and preparations included in Community herbal monographs and public statements has been carried out. The focus was herbal substances and preparations derived from non-European traditions. Of the 109 adopted Community herbal monographs, 10 are herbal substances used in Chinese traditional medicine. Where the HMPC issued a public statement because it was unable to elaborate a monograph more than half-involved herbal substances/preparations from non-European traditions. The main reasons herbal substances/preparations from non-European traditions were not accepted for inclusion in the Community herbal monographs have been identified as due to unfulfilled requirements of Directive 2004/24/EC. The most common reasons were the lack of evidence to demonstrate a 15-year minimum

  17. Exposures series

    OpenAIRE

    Stimson, Blake

    2011-01-01

    Reaktion Books’ Exposures series, edited by Peter Hamilton and Mark Haworth-Booth, is comprised of 13 volumes and counting, each less than 200 pages with 80 high-quality illustrations in color and black and white. Currently available titles include Photography and Australia, Photography and Spirit, Photography and Cinema, Photography and Literature, Photography and Flight, Photography and Egypt, Photography and Science, Photography and Africa, Photography and Italy, Photography and the USA, P...

  18. Effectiveness of Cognitive Behaviour Therapy for Mothers of Children with Food Allergy: A Case Series

    Directory of Open Access Journals (Sweden)

    Rebecca C. Knibb

    2015-11-01

    Full Text Available Background: Food allergy affects quality of life in patients and parents and mothers report high levels of anxiety and stress. Cognitive Behaviour Therapy (CBT may be helpful in reducing the psychological impact of food allergy. The aim of this study was to examine the appropriateness and effectiveness of CBT to improve psychological outcomes in parents of children with food allergy. Methods: Five parents (all mothers from a local allergy clinic requested to have CBT; six mothers acted as controls and completed questionnaires only. CBT was individual and face-to face and lasted 12 weeks. All participants completed measures of anxiety and depression, worry, stress, general mental health, generic and food allergy specific quality of life at baseline and at 12 weeks. Results: Anxiety, depression and worry in the CBT group significantly reduced and overall mental health and QoL significantly improved from baseline to 12 weeks (all p < 0.05 in mothers in the CBT group; control group scores remained stable. Conclusions: CBT appears to be appropriate and effective in mothers of children with food allergy and a larger randomised control trial now needs to be conducted. Ways in which aspects of CBT can be incorporated into allergy clinic visits need investigation.

  19. Synergistic effect of iontophoresis and a series of fatty acids on LHRH permeability through porcine skin.

    Science.gov (United States)

    Bhatia, K S; Singh, J

    1998-04-01

    The effect of chemical penetration enhancers (e.g., fatty acids) in combination with iontophoresis was examined on the in vitro permeability of luteinizing hormone releasing hormone (LHRH) through porcine skin. Porcine epidermis was pretreated with either ethanol (EtOH) or 10% fatty acid/EtOH. The permeability coefficient of LHRH was significantly (p Iontophoresis further enhanced the permeability of LHRH (p permeability. Among saturated fatty acids tested, 10% palmitic acid/iontophoresis showed the highest permeability coefficient [(59.52 +/- 2.40) x 10(-4) cm/h], which was approximately 16-fold higher than that of the control [(3.57 +/- 0.41) x 10(-4) cm/h]. Unsaturated cis-octadecenoic acids were more effective penetration enhancers when compared with octadecanoic acid. Among cis-octadecenoic acids in combination with EtOH, the greater iontophoretic permeability coefficient [(59.18 +/- 12.43) x 10(-4) cm/h] was obtained through linolenic acid treated epidermis, which was significantly greater (p iontophoresis treated epidermis was significantly (p < 0.05) reduced than the prerecovery value but could not completely recover to the baseline flux (i.e., flux of LHRH through untreated epidermis).

  20. Analysis of Spin-dependent Peltier Effect: Spin Valves Connected in Series

    Science.gov (United States)

    Jayathilaka, Priyanga; Belyea, Dustin; Eggers, Tatiana; Kirby, Hillary; Miller, Casey

    2013-03-01

    We are reporting a systematic study of planar Nernst effect (PNE) and Spin dependent Seebeck effect (SDSE) measurements and their relation to the Anisotropic Magneto Resistance (AMR) on Py thin films grown on SiOx substrates by magnetron sputtering. A 30nm thick Py film was followed by a 15nm of Ag cross electrodes. An in-situ mask exchanging system was allowed the Py and Ag to grow without breaking the vacuum. The sample was placed on top of two thermal baths which were independently controlled by a PID controller. A constant temperature gradient of 15K/cm was applied along the sample and the resultant voltages across the Ag electrodes were measured by nanovoltmeters as the field was swept. In measuring AMR no thermal gradient was applied, and a constant current was applied using a function generator. Both PNE and SDSE showed an AMR like field dependence and angular dependence. SDSE showed a Cos2 (θ) angular dependence and PNE showed a Sin (2 θ) angular dependence. AMR showed the same angular dependence along the Py film and across the Py film respectively. This suggests both PNE and SDSE behave similar to the AMR in thin films. Supported by NSF.

  1. Environmental occurrences, behavior, fate, and ecological effects of nanomaterials: an introduction to the special series.

    Science.gov (United States)

    Lowry, Gregory V; Hotze, Ernest M; Bernhardt, Emily S; Dionysiou, Dionysios D; Pedersen, Joel A; Wiesner, Mark R; Xing, Baoshan

    2010-01-01

    The release of engineered nanomaterials (ENMs) into the biosphere will increase as industries find new and useful ways to utilize these materials. Scientists and engineers are beginning to assess the material properties that determine the fate, transport, and effects of ENMs; however, the potential impacts of released ENMs on organisms, ecosystems, and human health remain largely unknown. This special collection of four review papers and four technical papers identifies many key and emerging knowledge gaps regarding the interactions between nanomaterials and ecosystems. These critical knowledge gaps include the form, route, and mass of nanomaterials entering the environment; the transformations and ultimate fate of nanomaterials in the environment; the transport, distribution, and bioavailability of nanomaterials in environmental media; and the organismal responses to nanomaterial exposure and effects of nanomaterial inputs, on ecological communities and biogeochemical processes at relevant environmental concentrations and forms. This introductory section summarizes the state of knowledge and emerging areas of research needs identified within the special collection. Despite recent progress in understanding the transport, transformations, and fate of ENMs in model environments and organisms, there remains a large need for fundamental information regarding releases, distribution, transformations and persistence, and bioavailability of nanomaterials. Moreover, fate, transport, bioaccumulation, and ecological impacts research is needed using environmentally relevant concentrations and forms of ENMs in real field materials and with a broader range of organisms.

  2. Extraction of Channel Length Independent Series Resistance for Deeply Scaled Metal-Oxide-Semiconductor Field-Effect Transistors

    Science.gov (United States)

    Ma, Li-Juan; Ji, Xiao-Li; Chen, Yuan-Cong; Xia, Hao-Guang; Zhu, Chen-Xin; Guo, Qiang; Yan, Feng

    2014-09-01

    The recently developed four Rsd extraction methods from a single device, involving the constant-mobility method, the direct Id—Vgs method, the conductance method and the Y-function method, are evaluated on 32 nm n-channel metal-oxide-semiconductor field-effect transistors (nMOSFETs). It is found that Rsd achieved from the constant-mobility method exhibits the channel length independent characteristics. The L-dependent Rsd extracted from the other three methods is proven to be associated with the gate-voltage-induced mobility degradation in the extraction procedures. Based on L-dependent behaviors of Rsd, a new method is proposed for accurate series resistance extraction on deeply scaled MOSFETs.

  3. A new series of diarylamides possessing quinoline nucleus: Synthesis, in vitro anticancer activities, and kinase inhibitory effect.

    Science.gov (United States)

    El-Gamal, Mohammed I; Khan, Mohammad Ashrafuddin; Abdel-Maksoud, Mohammed S; Gamal El-Din, Mahmoud M; Oh, Chang-Hyun

    2014-11-24

    Synthesis of a new series of diarylamides possessing 6,7-dimethoxy(dihydroxy)quinoline scaffold is described. Their in vitro antiproliferative activities against NCI-58 human cancer cell lines of nine different cancer types were tested. Compounds 1a and 1d-g showed the highest mean %inhibition values over the 58 cell line panel at 10 μM, and they were further tested in 5-dose testing mode to determine their IC50 values. The five compounds were more potent than Imatinib against all the cell lines of nine different cancer types. Compound 1g showed the highest potencies. It showed inhibitory effect against C-RAF kinase (76.65% at 10 μM concentration).

  4. Scattering Analysis of a Compact Dipole Array with Series and Parallel Feed Network including Mutual Coupling Effect

    Directory of Open Access Journals (Sweden)

    H. L. Sneha

    2013-01-01

    Full Text Available The current focus in defense arena is towards the stealth technology with an emphasis to control the radar cross-section (RCS. The scattering from the antennas mounted over the platform is of prime importance especially for a low-observable aerospace vehicle. This paper presents the analysis of the scattering cross section of a uniformly spaced linear dipole array. Two types of feed networks, that is, series and parallel feed networks, are considered. The total RCS of phased array with either kind of feed network is obtained by following the signal as it enters through the aperture and travels through the feed network. The RCS estimation of array is done including the mutual coupling effect between the dipole elements in three configurations, that is, side-by-side, collinear, and parallel-in-echelon. The results presented can be useful while designing a phased array with optimum performance towards low observability.

  5. Effects of rare earth oxides on dielectric properties of Y_2Ti_2O_7 series ceramics

    Institute of Scientific and Technical Information of China (English)

    丁佳钰; 肖瑗; 韩朋德; 张其土

    2010-01-01

    A series of Y2Ti2O7 microwave dielectric ceramics were synthesized by conventional solid-state method. The effects of rare earth oxide (La2O3, CeO2, Nd2O3, Sm2O3, Eu2O3, Gd2O3 and Dy2O3) and Nd2O3 doping content on the microstructure and dielectric properties of Y2Ti2O7 ceramics were investigated. The experimental results showed that the rare earth ions were considered to dissolve in Y-sites of the pyrochlore structure, different rare earth oxides and concentration had different influences on Y2Ti2O7 cerami...

  6. Elements for a of Rural Research Methodology. Sociological Monographs and the Rural Sociological Atlas

    Directory of Open Access Journals (Sweden)

    VERONICA DUMITRAŞCU

    2009-04-01

    Full Text Available This article attempts to provide an "X-ray image" of rural life through the inventory of certain research methods and techniques used in the study of Romanian rural communities. Sociological monographs, including the sociological rural atlas,were the epitome of Gustian sociology. The investigation of rural life focusing on certain key aspects - economic, political, and religious - simultaneously, can provide a more comprehensive perspective on the Romanian village than would be possible by considering each of these elements on its own. Hence, the monograph brings unity to past and present realities. The dynamic character of sociology, on which the Sociological School of Bucharest focused, can be applied nowadays as well. The sociologist is called forth now more than ever in order to interfere with social life. In this case, the methodological tool, that is the monograph, is very useful. Through the Social Atlas, the problems of rural communities can be anticipated and diagnosed and, as such, certain serious problems which take place in a social dimension can be averted. Hence, the Social Atlas project is very useful for research on rural life, as the maps capture the progress of social change.

  7. Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction.

    Science.gov (United States)

    Basalo, Carlos; Mohn, Tobias; Hamburger, Matthias

    2006-10-01

    The extraction methods in selected monographs of the European and the Swiss Pharmacopoeia were compared to pressurized liquid extraction (PLE) with respect to the yield of constituents to be dosed in the quantitative assay for the respective herbal drugs. The study included five drugs, Belladonnae folium, Colae semen, Boldo folium, Tanaceti herba and Agni casti fructus. They were selected to cover different classes of compounds to be analyzed and different extraction methods to be used according to the monographs. Extraction protocols for PLE were optimized by varying the solvents and number of extraction cycles. In PLE, yields > 97 % of extractable analytes were typically achieved with two extraction cycles. For alkaloid-containing drugs, the addition of ammonia prior to extraction significantly increased the yield and reduced the number of extraction cycles required for exhaustive extraction. PLE was in all cases superior to the extraction protocol of the pharmacopoeia monographs (taken as 100 %), with differences ranging from 108 % in case of parthenolide in Tanaceti herba to 343 % in case of alkaloids in Boldo folium.

  8. The CLEAN Workshop Series: Promoting Effective Pedagogy for Teaching Undergraduate Climate Science

    Science.gov (United States)

    Kirk, K. B.; Bruckner, M. Z.; Manduca, C. A.; Buhr, S. M.

    2012-12-01

    To prepare students to understand a changing climate, it is imperative that we equip educators with the best possible tools and methods for reaching their audience. As part of the Climate Literacy and Energy Awareness Network (CLEAN) professional development efforts, two workshops for undergraduate faculty were held in 2012. These workshops used a variety of activities to help faculty learn about recent climate research, take part in demonstrations of successful activities for teaching climate topics, and collaborate to create new teaching materials. The workshops also facilitated professional networking among participants. Both workshops were held online, eliminating the need for travel, encouraging participants without travel funds to attend, and allowing international collaborations and presentations. To create an authentic experience, the workshop used several technologies such as the Blackboard Collaborate web conferencing platform, SERC's web-based collaboration tools and online discussion threads, and conference calls. The workshop Communicating Climate Science in the Classroom, held in April 2012, explored practices for communicating climate science and policy in the classroom and provided strategies to improve student understanding of this complex and sensitive topic. Workshop presentations featured public opinion research on Americans' perceptions of climate change, tactics for identifying and resolving student misconceptions, and methods to address various "backfire effects" that can result from attempts to correct misinformation. Demonstrations of teaching approaches included a role-playing simulation of emissions negotiations, Princeton's climate stabilization wedges game, and an activity that allows students to use scientific principles to tackle misinformation. The workshop Teaching Climate Complexity was held in May 2012. Teaching the complexities of climate science requires an understanding of many facets of the Earth system and a robust pedagogic

  9. Effects of measurement resolution on the analysis of temperature time series for stream-aquifer flux estimation

    Science.gov (United States)

    Soto-López, Carlos D.; Meixner, Thomas; Ferré, Ty P. A.

    2011-12-01

    From its inception in the mid-1960s, the use of temperature time series (thermographs) to estimate vertical fluxes has found increasing use in the hydrologic community. Beginning in 2000, researchers have examined the impacts of measurement and parameter uncertainty on the estimates of vertical fluxes. To date, the effects of temperature measurement discretization (resolution), a characteristic of all digital temperature loggers, on the determination of vertical fluxes has not been considered. In this technical note we expand the analysis of recently published work to include the effects of temperature measurement resolution on estimates of vertical fluxes using temperature amplitude and phase shift information. We show that errors in thermal front velocity estimation introduced by discretizing thermographs differ when amplitude or phase shift data are used to estimate vertical fluxes. We also show that under similar circumstances sensor resolution limits the range over which vertical velocities are accurately reproduced more than uncertainty in temperature measurements, uncertainty in sensor separation distance, and uncertainty in the thermal diffusivity combined. These effects represent the baseline error present and thus the best-case scenario when discrete temperature measurements are used to infer vertical fluxes. The errors associated with measurement resolution can be minimized by using the highest-resolution sensors available. But thoughtful experimental design could allow users to select the most cost-effective temperature sensors to fit their measurement needs.

  10. Series resistance effect on time zero dielectrics breakdown characteristics of MOSCAP with ultra-thin EOT high-k/metal gate stacks

    Science.gov (United States)

    Hao, Xu; Hong, Yang; Yanrong, Wang; Wenwu, Wang; Guangxing, Wan; Shangqing, Ren; Weichun, Luo; Luwei, Qi; Chao, Zhao; Dapeng, Chen; Xinyu, Liu; Tianchun, Ye

    2016-05-01

    The time zero dielectric breakdown characteristics of MOSCAP with ultra-thin EOT high-k metal gate stacks are studied. The TZDB results show an abnormal area dependence due to the series resistance effect. The series resistance components extracted from the Fowler-Nordheim tunneling relation are attributed to the spreading resistance due to the asymmetry electrodes. Based on a series model to eliminate the series resistance effect, an area acceleration dependence is obtained by correcting the TZDB results. The area dependence follows Poisson area scaling rules, which indicates that the mechanism of TZDB is the same as TDDB and could be considered as a trap generation process. Project supported by the National High Technology Research and Development Program (863 Program) of China (No. SS2015AA010601), the National Natural Science Foundation of China (Nos. 61176091, 61306129), and the Opening Project of the Key Laboratory of Microelectronics Devices & Integrated Technology, Institute of Microelectronics, Chinese Academy of Sciences.

  11. Low energy ion-solid interactions and chemistry effects in a series of pyrochlores

    Energy Technology Data Exchange (ETDEWEB)

    Dong, Liyuan [School of Nuclear Science and Technology, Lanzhou University, Lanzhou Gansu China; Li, Yuhong [School of Nuclear Science and Technology, Lanzhou University, Lanzhou Gansu China; Devanathan, Ram [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland Washington; Setyawan, Wahyu [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland Washington; Gao, Fei [Department of Nuclear Engineering & Radiological Sciences, University of Michigan, Ann Arbor Michigan

    2017-04-03

    The effect of chemistry on low energy recoil events was investigated at 10 K for each type of atom in pyrochlores using molecular dynamics simulation. Contour plots of the threshold displacement energy (Ed) in Gd2Zr2O7 have been produced along more than 80 directions for each individual species. The Ed surface for each type of atom in Gd2Zr2O7 is highly anisotropic; Ed of Zr exhibits the largest degree of anisotropy, while that of O8b exhibits the smallest. The recommended values of Ed in Gd2Zr2O7 based on the observed minima are 56, 94 and 25 eV, respectively for Gd, Zr and O. The influence of cation radius on Ed in pyrochlores A2B2O7 (with A-site ranging from Lu3+ to La3+ and B-site ranging from Ti4+ to Ce4+) was also investigated along three directions [100], [110] and [111]. The Ed in pyrochlores strongly depended on the atom type, atom mass, knock-on direction, and lattice position. The defects produced after low energy displacement events included cation antisite defects, cation Frenkel pairs, anion Frenkel pairs, various vacancies and interstitials. Ce doping in pyrochlores may affect the radiation response, because it resulted in drastic changes in cation and anion displacement energies and formation of an unusual type of anti-site defect. This work demonstrates links between Ed and amorphization resistance.

  12. Interrupted time-series analysis yielded an effect estimate concordant with the cluster-randomized controlled trial result.

    Science.gov (United States)

    Fretheim, Atle; Soumerai, Stephen B; Zhang, Fang; Oxman, Andrew D; Ross-Degnan, Dennis

    2013-08-01

    We reanalyzed the data from a cluster-randomized controlled trial (C-RCT) of a quality improvement intervention for prescribing antihypertensive medication. Our objective was to estimate the effectiveness of the intervention using both interrupted time-series (ITS) and RCT methods, and to compare the findings. We first conducted an ITS analysis using data only from the intervention arm of the trial because our main objective was to compare the findings from an ITS analysis with the findings from the C-RCT. We used segmented regression methods to estimate changes in level or slope coincident with the intervention, controlling for baseline trend. We analyzed the C-RCT data using generalized estimating equations. Last, we estimated the intervention effect by including data from both study groups and by conducting a controlled ITS analysis of the difference between the slope and level changes in the intervention and control groups. The estimates of absolute change resulting from the intervention were ITS analysis, 11.5% (95% confidence interval [CI]: 9.5, 13.5); C-RCT, 9.0% (95% CI: 4.9, 13.1); and the controlled ITS analysis, 14.0% (95% CI: 8.6, 19.4). ITS analysis can provide an effect estimate that is concordant with the results of a cluster-randomized trial. A broader range of comparisons from other RCTs would help to determine whether these are generalizable results. Copyright © 2013 Elsevier Inc. All rights reserved.

  13. A case series of the effects of a novel composition of a traditional natural preparation for the treatment of psoriasis.

    Science.gov (United States)

    Michalsen, A; Eddin, O; Salama, A

    2016-10-01

    The objective of this study was to assess the effectiveness of a specific composition of a traditional herbal preparation (DurrDerma) in adult patients with moderate to severe skin psoriasis. The preparation is a newly developed topical combination containing plant-based extracts traditionally used in skin disease as black cumin, olive oil, tea tree oil, cocoa butter completed by vitamin A and vitamin B12. We documented the effectiveness of the preparation in a first case series. A total of 12 patients (8 males and 4 females, 21-86 y) with manifest and treatment-resistant psoriasis were included and treated for 12 weeks. All patients were assigned to twice-daily treatment with the DurrDerma preparation. Treatment success as determined by the Psoriasis Area and Severity Index (PASI) score, the body surface area, and the dermatology life index was achieved (PASI reduction of >75%) in 10 of the 12 treated patients (83%). The remaining two patients showed a PASI reduction of ≤50%. In 5 of the patients PASI reduction was achieved <12 weeks (between week 3-11). The beneficial effect in responder patients might be explained by a synergistic anti-oxidative and anti inflammatory activity of all components present in DurrDerma. We conclude that the new preparation using a traditional approach seems to be a promising complementary treatment for psoriasis.

  14. A case series of the effects of a novel composition of a traditional natural preparation for the treatment of psoriasis

    Directory of Open Access Journals (Sweden)

    A. Michalsen

    2016-10-01

    Full Text Available The objective of this study was to assess the effectiveness of a specific composition of a traditional herbal preparation (DurrDerma in adult patients with moderate to severe skin psoriasis. The preparation is a newly developed topical combination containing plant-based extracts traditionally used in skin disease as black cumin, olive oil, tea tree oil, cocoa butter completed by vitamin A and vitamin B12. We documented the effectiveness of the preparation in a first case series. A total of 12 patients (8 males and 4 females, 21–86 y with manifest and treatment-resistant psoriasis were included and treated for 12 weeks. All patients were assigned to twice-daily treatment with the DurrDerma preparation. Treatment success as determined by the Psoriasis Area and Severity Index (PASI score, the body surface area, and the dermatology life index was achieved (PASI reduction of >75% in 10 of the 12 treated patients (83%. The remaining two patients showed a PASI reduction of ≤50%. In 5 of the patients PASI reduction was achieved <12 weeks (between week 3–11. The beneficial effect in responder patients might be explained by a synergistic anti-oxidative and anti inflammatory activity of all components present in DurrDerma. We conclude that the new preparation using a traditional approach seems to be a promising complementary treatment for psoriasis.

  15. Comparative Analysis of Compatibility Effects on Invigorating Blood Circulation for Cyperi Rhizoma Series of Herb Pairs Using Untargeted Metabolomics

    Directory of Open Access Journals (Sweden)

    Pei Liu

    2017-09-01

    Full Text Available The mutual-assistance compatibility of Cyperi Rhizoma (Xiangfu, XF and Angelicae Sinensis Radix (Danggui, DG, Chuanxiong Rhizoma (Chuanxiong, CX, Paeoniae Radix Alba (Baishao, BS, or Corydalis Rhizoma (Yanhusuo, YH, found in a traditional Chinese medicine (TCM named Xiang-Fu-Si-Wu Decoction (XFSWD, can produce synergistic and promoting blood effects. Nowadays, XFSWD has been proved to be effective in activating blood circulation and dissipating blood stasis. However, the role of the herb pairs synergistic effects in the formula were poorly understood. In order to quantitatively assess the compatibility effects of herb pairs, mass spectrometry-based untargeted metabolomics studies were performed. The plasma and urine metabolic profiles of acute blood stasis rats induced by adrenaline hydrochloride and ice water and administered with Cyperi Rhizoma—Angelicae Sinensis Radix (XD, Cyperi Rhizoma—Chuanxiong Rhizoma (XC, Cyperi Rhizoma—Paeoniae Radix Alba (XB, Cyperi Rhizoma—Corydalis Rhizoma (XY were compared. Relative peak area of identified metabolites was calculated and principal component analysis (PCA score plot from the potential markers was used to visualize the overall differences. Then, the metabolites results were used with biochemistry indicators and genes expression values as parameters to quantitatively evaluate the compatibility effects of XF series of herb pairs by PCA and correlation analysis. The collective results indicated that the four XF herb pairs regulated glycerophospholipid metabolism, steroid hormone biosynthesis and arachidonic acid metabolism pathway. XD was more prominent in regulating the blood stasis during the four XF herb pairs. This study demonstrated that metabolomics was a useful tool to efficacy evaluation and compatibility effects of TCM elucidation.

  16. Effect of Intensive Atropine Doses (Rapid Incremental Loading and Titration for Management of Organophosphorus Pesticide Poisoning: a Case Series

    Directory of Open Access Journals (Sweden)

    Abu Saleh Ahmed

    2014-03-01

    Full Text Available Background:Acute poisoning with organophosphorus (OP pesticides is a common method of suicide and entails considerable mortality in Bangladesh. The objective of this study was to evaluate the effects and outcomes of a protocol for treatment of OP poisoning that included titrated incremental atropine as loading dose and slow infusion for maintenance.  Methods:In this prospective descriptive case series, definitive OP poisoned patients were enrolled in an adult medicine unit of Dhaka Medical College Hospital from April 2006 to April 2007. Clinical examinations were done as soon as the patient entered the ward. Patient’s demographics, comorbid conditions and the occurrence of specific clinical outcomes including death, need for assisted ventilation and clinical complications were recorded. The patients were treated according to the protocol. Results: A total of 56 patients were enrolled over the study period. The median age of the study population was 22.5 years. Most patients were men (67.8%. The most common clinical presentation was miosis (58.9%. In total, 11 patients died (19.6%. Intermediate syndrome developed in 12 patients (21.4% and 6 of them died. Assisted ventilation was required in 16 cases (28.5. Patients with diastolic blood pressure ≤ 70 mmHg and/or GCS ≤ 10 were significantly less likely to survive (P = 0.02, 0.006, respectively. Moreover, early respiratory failure (P < 0.001 and the need for assisted ventilation (P < 0.001 were significantly higher among deceased cases. The mortality rate in this study was similar to previous studies. The frequency of atropine toxicity in the present study (1.8% was considerably lower than conventional regimen used in previous studies. Conclusion:Using the new protocol, lower rate of atropine toxicity developed in victims. Hence, the new protocol appears to be safer and its effectiveness should be further evaluated in case control studies in Bangladesh.    How to cite this article: Ahmed AS

  17. Transportation Energy Futures Series: Effects of Travel Reduction and Efficient Driving on Transportation: Energy Use and Greenhouse Gas Emissions

    Energy Technology Data Exchange (ETDEWEB)

    Porter, C. D.; Brown, A.; DeFlorio, J.; McKenzie, E.; Tao, W.; Vimmerstedt, L.

    2013-03-01

    Since the 1970s, numerous transportation strategies have been formulated to change the behavior of drivers or travelers by reducing trips, shifting travel to more efficient modes, or improving the efficiency of existing modes. This report summarizes findings documented in existing literature to identify strategies with the greatest potential impact. The estimated effects of implementing the most significant and aggressive individual driver behavior modification strategies range from less than 1% to a few percent reduction in transportation energy use and GHG emissions. Combined strategies result in reductions of 7% to 15% by 2030. Pricing, ridesharing, eco-driving, and speed limit reduction/enforcement strategies are widely judged to have the greatest estimated potential effect, but lack the widespread public acceptance needed to accomplish maximum results. This is one of a series of reports produced as a result of the Transportation Energy Futures (TEF) project, a Department of Energy-sponsored multi-agency project initiated to pinpoint underexplored strategies for abating GHGs and reducing petroleum dependence related to transportation.

  18. Transportation Energy Futures Series. Effects of Travel Reduction and Efficient Driving on Transportation. Energy Use and Greenhouse Gas Emissions

    Energy Technology Data Exchange (ETDEWEB)

    Porter, C. D. [National Renewable Energy Lab. (NREL) and Cambridge Systematics, Golden, CO (United States); Brown, A. [National Renewable Energy Lab. (NREL) and Cambridge Systematics, Golden, CO (United States); DeFlorio, J. [National Renewable Energy Lab. (NREL) and Cambridge Systematics, Golden, CO (United States); McKenzie, E. [National Renewable Energy Lab. (NREL) and Cambridge Systematics, Golden, CO (United States); Tao, W. [National Renewable Energy Lab. (NREL) and Cambridge Systematics, Golden, CO (United States); Vimmerstedt, L. [National Renewable Energy Lab. (NREL) and Cambridge Systematics, Golden, CO (United States)

    2013-03-01

    Since the 1970s, numerous transportation strategies have been formulated to change the behavior of drivers or travelers by reducing trips, shifting travel to more efficient modes, or improving the efficiency of existing modes. This report summarizes findings documented in existing literature to identify strategies with the greatest potential impact. The estimated effects of implementing the most significant and aggressive individual driver behavior modification strategies range from less than 1% to a few percent reduction in transportation energy use and GHG emissions. Combined strategies result in reductions of 7% to 15% by 2030. Pricing, ridesharing, eco-driving, and speed limit reduction/enforcement strategies are widely judged to have the greatest estimated potential effect, but lack the widespread public acceptance needed to accomplish maximum results. This is one of a series of reports produced as a result of the Transportation Energy Futures (TEF) project, a Department of Energy-sponsored multi-agency project initiated to pinpoint underexplored strategies for abating GHGs and reducing petroleum dependence related to transportation.

  19. Holistic Integrative Analysis of International Change: A Commentary on Teaching Emergent Futures (Proteus Monograph Series. Volume 1, Issue 3)

    Science.gov (United States)

    2008-01-01

    Mayan insurgency, often related to recurrent globalization- style regional development agendas, throughout their history; but in the former, a modern...system as having occurred when “all the civil structures simply turn their backs on the aggressors” (Havel 1991, 109), a subtle syndromes shift that

  20. Intelligence Scotomas in Central and South America (The Proteus Monograph Series, Volume 1, Issue 4, March 2008)

    Science.gov (United States)

    2008-03-01

    was a member of the National Research Council Committee for Assessment of Non-Lethal Weapons Science and Technology . Dr. Alexander entered the U.S...cultures, ranging from technologically advanced, cosmopolitan groups, to “uncontacted people” still living in ever-shrinking forested areas of...Ford, CitiBank , Blockbuster Video, and that ever-popular symbol, McDonalds. A few government buildings have also been bombed, but there are rarely

  1. Economics in Asia: Status Reports on Teaching and Research in Nine Countries. RUSHSAP Series on Occasional Monographs and Papers, 14.

    Science.gov (United States)

    United Nations Educational, Scientific and Cultural Organization, Bangkok (Thailand). Principal Regional Office for Asia and the Pacific.

    This book contains reports on the teaching of and research in economics in nine countries: India, Indonesia, Malaysia, Nepal, the Philippines, Republic of Korea, Sri Lanka, Thailand, and Viet Nam. Each report covers the historical development and growth of the discipline in the country; the development of infra-structures for teaching and…

  2. Translating Theory into Practice: Implications of Japanese Management Theory for Student Personnel Administrators. NASPA Monograph Series Volume 3. First Edition.

    Science.gov (United States)

    Deegan, William L.; And Others

    Japanese management theory was studied to identify specific models for consideration by student personnel administrators. The report is organized into three sections: major components of Japanese management theory, potential implications for student personnel administration, and three models, based on components of Japanese management theory, for…

  3. The New Professional: A Resource Guide for New Student Affairs Professionals and Their Supervisors. Monograph Series Volume 10.

    Science.gov (United States)

    Coleman, David D., Ed.; And Others

    This resource guide for new student affairs professionals reflects on the socialization process experienced by new staff members and offers senior student affairs staff members and graduate preparation program faculty insights to assist them in designing programs for preservice students and new full-time staff appointees. "The New Professional"…

  4. In Times of Challenge: Chicanos and Chicanas in American Society. Mexican American Studies Monograph Series No. 6.

    Science.gov (United States)

    Garcia, Juan R., Ed; And Others

    This anthology compiles articles and essays on Chicano and Chicana political concerns in the 1980's, on cultural aspects of the Chicano experience, and on historical issues and events. The papers are: (1) "Chicano Politics after 1984" by Christine Marie Sierra; (2) "Hacia una Teoria para la Liberacion de la Mujer" (analysis of the relationship of…

  5. Approaches to Research on Teacher Education and Technology. Society for Technology and Teacher Education Monograph Series. No. 1.

    Science.gov (United States)

    Waxman, Hersholt C., Ed.; Bright, George W., Ed.

    This document addresses the use of technology to enrich education. Twelve papers discuss research programs and perspectives and methods of research in technology and teacher education. Titles are: "Research Methods and Paradigms in Technology and Teacher Education" (Hersholt C. Waxman and George W. Bright); "Past and Future Stages in Educational…

  6. The Vietnam Drug User Returns. Final Report. Special Action Office Monograph, Series A, Number 2, May 1974.

    Science.gov (United States)

    Robins, Lee N.

    This report, based upon case records and follow-up interviews with 965 U.S. Servicemen returning from Vietnam investigates: (1) the availability and utilization of narcotics, marihuana and alcohol in Vietnam; (2) the psychosocial and demographic predictors of pre- and post-Vietnam narcotic use; and (3) the post-Vietnam adjustment difficulties of…

  7. Proceedings of the Annual Nebraska Aviation Education Association Conference (1st, Omaha, Nebraska, January 1994). The UNO Aviation Monograph Series.

    Science.gov (United States)

    Crehan, James E., Ed.

    This collection of six papers constitutes the proceedings of the First Annual Conference of the Nebraska Aviation Education Association. These papers present many issues that the discipline of aviation is confronting, including those related to the aviation industry. The papers included are as follows: (1) "Using the DAT for Selection of…

  8. Partners in the Parks: Field Guide to an Experiential Program in the National Parks. National Collegiate Honors Council Monograph Series

    Science.gov (United States)

    Digby, Joan

    2010-01-01

    The aim of Partners in the Parks (PITP) from its inception has been to introduce, or reintroduce, collegiate honors students to this country: not the transformed environment that we have constructed on its surface but the bedrock world upon which it rests. Like de Toqueville, Jefferson, Thoreau, Emerson, and so many others, these authors…

  9. Shaken Not Stirred? The Development of One Tertiary Education Sector in Australia. NCVER Monograph Series 08/2012

    Science.gov (United States)

    Wheelahan, Leesa; Arkoudis, Sophie; Moodie, Gavin; Fredman, Nick; Bexley, Emmaline

    2012-01-01

    The sectoral divide between vocational education and training (VET) and higher education in Australia is blurring as a consequence of broader social and economic pressures for a more highly skilled population, but also as a consequence of government policies designed to develop tertiary education markets and to diversify institutional types. The…

  10. In Times of Challenge: Chicanos and Chicanas in American Society. Mexican American Studies Monograph Series No. 6.

    Science.gov (United States)

    Garcia, Juan R., Ed; And Others

    This anthology compiles articles and essays on Chicano and Chicana political concerns in the 1980's, on cultural aspects of the Chicano experience, and on historical issues and events. The papers are: (1) "Chicano Politics after 1984" by Christine Marie Sierra; (2) "Hacia una Teoria para la Liberacion de la Mujer" (analysis of…

  11. Distinctions between Self-Esteem and Narcissism: Implications for Practice. Perspectives from ERIC/EECE: A Monograph Series, No. 5.

    Science.gov (United States)

    Katz, Lilian G.

    The purpose of this essay is to explore contemporary early childhood educational practices related to self-esteem and to distinguish self-esteem from narcissism. After discussing practices and materials that are intended to foster self-esteem but may contribute to self-preoccupation, the essay examines some of the distinctions between self-esteem…

  12. The Effect of Extension Service's Youth Nutrition Lesson Series on Behavioral Change in EFNEP Youth Utilizing Different Educational Environments and Teachers.

    Science.gov (United States)

    Boone, Edgar J.; White, Estelle E.

    The pilot evaluative study of the use and effectiveness of the Expanded Food and Nutrition Education Program (EFNEP) Youth Nutrition Lesson Series focused upon its effectiveness in producing nutrition behavior change (nutrition knowledge, nutrition attitudes, and food intake) based upon the concepts, values, and principles presented in lessons 1-6…

  13. Beneficial effect of botulinum toxin A on Raynaud's phenomenon in Japanese patients with systemic sclerosis: A prospective, case series study.

    Science.gov (United States)

    Motegi, Sei-ichiro; Yamada, Kazuya; Toki, Sayaka; Uchiyama, Akihiko; Kubota, Yuka; Nakamura, Tetsuya; Ishikawa, Osamu

    2016-01-01

    Currently, there is no satisfactory treatment for Raynaud's phenomenon (RP) in systemic sclerosis (SSc). Recently, it has been reported that botulinum toxin A (BTX-A) injection was effective for the treatment of RP in SSc patients. The objective was to assess the efficacy and safety of BTX-A on RP in Japanese SSc patients. In the prospective, case series study, 10 Japanese SSc patients with RP received 10 U of BTX-A injections into the hand. The change in severity of RP, including the frequency of attacks/pain, color changes, duration time of RP and the severity of pain, was assessed by Raynaud's score and pain visual analog scale (VAS) at each visit during 16 weeks. The recovery of skin temperature 20 min after cold water stimulation was examined by thermography at baseline and 4 weeks after injection. The number of digital ulcers (DU) and adverse effects were assessed at each visit. BTX-A injection decreased Raynaud's score and pain VAS from 2 weeks after injection, and the suppressive effect was continued until 16 weeks after injection. Skin temperature recovery after cold water stimulation at 4 weeks after injection was significantly enhanced compared with that before injection. All DU in five patients were healed within 12 weeks after injection. Neither systemic nor local adverse effects were observed in all cases. We conclude that BTX-A injection significantly improved the activity of RP in SSc patients without any adverse events, suggesting that BTX-A may have possible long-term preventive and therapeutic potentials for RP in Japanese SSc patients.

  14. Effectiveness and Safety of Sitagliptin in Patients with Beta-thalassaemia Major and Diabetes Mellitus: A Case Series

    Directory of Open Access Journals (Sweden)

    Shahrzad Zonoozi

    2017-01-01

    Full Text Available Sitagliptin, a modern antidiabetic agent which is weight neutral and associated with low rate of hypoglycaemias, is being increasingly used in type 2 diabetes mellitus (DM. However there is paucity of data about its efficacy and safety in beta-thalassaemia major (β-TM. This retrospective case series of five patients (mean age of 45 years is the first study evaluating the use of sitagliptin in patients with β-TM and DM. Four patients responded well to sitagliptin, as evidenced by decrease in fructosamine by 77 and 96µmol/L (equivalent reduction in HbA1c of 1.5% and 1.9% observed in two patients and reduction in the frequency of hypoglycaemia without worsening glycaemic control in two others. One patient did not respond to sitagliptin. No patients reported significant side effects. This study provides evidence that sitagliptin may be considered, with caution, for use in patients with β-TM and DM, under the close monitoring of a Diabetologist.

  15. Transportation Energy Futures Series. Effects of the Built Environment on Transportation. Energy Use, Greenhouse Gas Emissions, and Other Factors

    Energy Technology Data Exchange (ETDEWEB)

    Porter, C. D. [National Renewable Energy Lab. (NREL) and Cambridge Systematics, Inc., Golden, CO (United States); Brown, A. [National Renewable Energy Lab. (NREL) and Cambridge Systematics, Inc., Golden, CO (United States); Dunphy, R. T. [National Renewable Energy Lab. (NREL) and Cambridge Systematics, Inc., Golden, CO (United States); Vimmerstedt, L. [National Renewable Energy Lab. (NREL) and Cambridge Systematics, Inc., Golden, CO (United States)

    2013-03-15

    Planning initiatives in many regions and communities aim to reduce transportation energy use, decrease emissions, and achieve related environmental benefits by changing land use. This report reviews and summarizes findings from existing literature on the relationship between the built environment and transportation energy use and greenhouse gas emissions, identifying results trends as well as potential future actions. The indirect influence of federal transportation and housing policies, as well as the direct impact of municipal regulation on land use are examined for their effect on transportation patterns and energy use. Special attention is given to the 'four D' factors of density, diversity, design and accessibility. The report concludes that policy-driven changes to the built environment could reduce transportation energy and GHG emissions from less than 1% to as much as 10% by 2050, the equivalent of 16%-18% of present-day urban light-duty-vehicle travel. This is one of a series of reports produced as a result of the Transportation Energy Futures (TEF) project, a Department of Energy-sponsored multi-agency project initiated to pinpoint underexplored strategies for abating GHGs and reducing petroleum dependence related to transportation.

  16. Transportation Energy Futures Series: Effects of the Built Environment on Transportation: Energy Use, Greenhouse Gas Emissions, and Other Factors

    Energy Technology Data Exchange (ETDEWEB)

    Porter, C. D.; Brown, A.; Dunphy, R. T.; Vimmerstedt, L.

    2013-03-01

    Planning initiatives in many regions and communities aim to reduce transportation energy use, decrease emissions, and achieve related environmental benefits by changing land use. This report reviews and summarizes findings from existing literature on the relationship between the built environment and transportation energy use and greenhouse gas emissions, identifying results trends as well as potential future actions. The indirect influence of federal transportation and housing policies, as well as the direct impact of municipal regulation on land use are examined for their effect on transportation patterns and energy use. Special attention is given to the 'four D' factors of density, diversity, design and accessibility. The report concludes that policy-driven changes to the built environment could reduce transportation energy and GHG emissions from less than 1% to as much as 10% by 2050, the equivalent of 16%-18% of present-day urban light-duty-vehicle travel. This is one of a series of reports produced as a result of the Transportation Energy Futures (TEF) project, a Department of Energy-sponsored multi-agency project initiated to pinpoint underexplored strategies for abating GHGs and reducing petroleum dependence related to transportation.

  17. Effect of pineapple cropping on soil chemical and physical changes in Tha-yang soil series, Petchaburi province

    Directory of Open Access Journals (Sweden)

    Isuwan, A.

    2007-03-01

    Full Text Available The experiment was conducted to investigate the effect of pineapple cropping on chemical and physical property changes of Tha-yang soil series, located on Tumbon Nong-ya-plong, Amphor Nong-yaplong,Petchaburi province. The experimental treatments were the different pineapple cropping soil ages arranged in a completely randomized design, consisting of undisturbed soil (year 0 and pineapple croppingsoil ages of 1, 4 and 8 years with 4 replications each. Soil samples were separated according to the soil level, namely Top-soil (0-15 cm. and Sub-soil (15-30 cm. for chemical and physical evaluation. The results showedthat soil chemical properties such as pH, OM, CEC, exchangeable Ca and Mg were decreased significantly (in both Top- and Sub-soil level, whereas available P and S were increased significantly in the 4-year soilsamples when compared with undisturbed soil. However, soil physical properties were not significantly different among cropping age treatments, except for clay particle in Top-soil which increased in the 4-year soil samples when compared with the 1-year soil samples and undisturbed soil. The results revealed thatpineapple cropping notably reduced soil fertility. As a result, soil resource management and plant nutrient management strategies must be carefully planned and implemented for sustainable pineapple production.

  18. Quantification of water-level variability effect on plant species populations using paleoecological and hydrological time series data

    Science.gov (United States)

    Roehl, Edwin A.; Conrads, Paul A.; Bernhardt, Christopher

    2012-01-01

    Soil cores provide valuable data on historical changes in vegetation and hydrologic conditions. Empirical models were developed to quantify the effect of meteorological and hydrologic forcing on plant species distributions over a 110-year period in Water Conservation Area 1 (WCA1) in the Florida Everglades, also known as the Arthur R. Marshall Loxahatchee National Wildlife Refuge. Empirical models that predict plant species distributions at sites within WCA1 were developed by linking temporally sparse seed bank data from soil cores with continuous multi-decadal daily meteorological and hydrologic time series data. The meteorological data included rainfall and maximum daily temperatures that spanned the entire study period of 110 years. The hydrologic data included stage data from two gages in WCA1 established in 1954. These stage data were hindcasted to be concurrent with the meteorological data by using correlation models that fit measured stages as a function of the meteorological parameters. The historical plant species data came from seven peat cores from WCA1. Different depths from each core were carbon-dated and assayed for relative percentages of 83 plant species using pollen counts. The oldest dates were more than 1,000 years old; however, only core data that overlapped the study period were used, for a total of 67 assays among the seven cores. Twenty-three of the species had ratios of at least 5 percent for one or more of the 67 assays, hereafter referred to as the "top23". Using the assays as input vectors, the top23 were grouped using the k-means clustering into four plant classes that represented the extent to which the various species have historically appeared together. This reduced the modeling problem to one of predicting the relative ratios of the four plant classes from the hindcasted stage time-series data. A separate empirical model was developed for each class using a multi-layer perceptron artificial neural network, which provides multivariate

  19. Phase stability in fMRI time series: effect of noise regression, off-resonance correction and spatial filtering techniques.

    Science.gov (United States)

    Hagberg, Gisela E; Bianciardi, Marta; Brainovich, Valentina; Cassara, Antonino Mario; Maraviglia, Bruno

    2012-02-15

    Although the majority of fMRI studies exploit magnitude changes only, there is an increasing interest regarding the potential additive information conveyed by the phase signal. This integrated part of the complex number furnished by the MR scanners can also be used for exploring direct detection of neuronal activity and for thermography. Few studies have explicitly addressed the issue of the available signal stability in the context of phase time-series, and therefore we explored the spatial pattern of frequency specific phase fluctuations, and evaluated the effect of physiological noise components (heart beat and respiration) on the phase signal. Three categories of retrospective noise reduction techniques were explored and the temporal signal stability was evaluated in terms of a physiologic noise model, for seven fMRI measurement protocols in eight healthy subjects at 3T, for segmented CSF, gray and white matter voxels. We confirmed that for most processing methods, an efficient use of the phase information is hampered by the fact that noise from physiological and instrumental sources contributes significantly more to the phase than to the magnitude instability. Noise regression based on the phase evolution of the central k-space point, RETROICOR, or an orthonormalized combination of these were able to reduce their impact, but without bringing phase stability down to levels expected from the magnitude signal. Similar results were obtained after targeted removal of scan-to-scan variations in the bulk magnetic field by the dynamic off-resonance in k-space (DORK) method and by the temporal off-resonance alignment of single-echo time series technique (TOAST). We found that spatial high-pass filtering was necessary, and in vivo a Gaussian filter width of 20mm was sufficient to suppress physiological noise and bring the phase fluctuations to magnitude levels. Stronger filters brought the fluctuations down to levels dictated by thermal noise contributions, and for 62

  20. DCP Series

    Directory of Open Access Journals (Sweden)

    Philip Stearns

    2011-06-01

    Full Text Available Photo essay. A collection of Images produced by intentionally corrupting the circuitry of a Kodak DC280 2 MP digitalcamera. By rewiring the electronics of a digital camera, glitched images are produced in a manner that parallels chemically processing unexposed film or photographic paper to produce photographic images without exposure to light. The DCP Series of Digital Images are direct visualizations of data generated by a digital camera as it takes a picture. Electronic processes associated with the normal operations of the camera, which are usually taken for granted, are revealed through an act of intervention. The camera is turned inside­out through complexes of short­circuits, selected by the artist, transforming the camera from a picture taking device to a data capturing device that renders raw data (electronic signals as images. In essence, these images are snap­shots of electronic signals dancing through the camera's circuits, manually rerouted, written directly to the on­board memory device. Rather than seeing images of the world through a lens, we catch a glimpse of what the camera sees when it is forced to peer inside its own mind.

  1. Effect of alignment changes on socket reaction moments during gait in transfemoral and knee-disarticulation prostheses: case series.

    Science.gov (United States)

    Kobayashi, Toshiki; Orendurff, Michael S; Boone, David A

    2013-09-27

    The alignment of a lower-limb prosthesis is critical to the successful prosthetic fitting and utilization by the wearer. Loads generated by the socket applied to the residual limb while walking are thought to be different in transfemoral and knee-disarticulation prostheses. The aim of this case series was to compare the socket reaction moments between transfemoral and knee-disarticulation prostheses and to investigate the effect of alignment changes on them. Two amputees, one with a transfemoral prosthesis and another with a knee-disarticulation prosthesis, participated in this study. A Smart Pyramid™ was used to measure socket reaction moments while walking under 9 selected alignment conditions; including nominally aligned, angle malalignments of 6° (flexion, extension, abduction and adduction) and translation malalignments of 15 mm (anterior, posterior, medial and lateral) of the socket relative to the foot. This study found that the pattern of the socket reaction moments was similar between transfemoral and knee-disarticulation prostheses. An extension moment in the sagittal plane and a varus moment in the coronal plane were dominant during stance under the nominally aligned condition. This study also demonstrated that alignment changes might have consistent effects on the socket reaction moments in transfemoral and knee-disarticulation prostheses. Extension and posterior translation of the socket resulted in increases in an extension moment, while abduction and lateral translation of the socket resulted in increases in a varus moment. The socket reaction moments may potentially serve as useful biomechanical parameters to evaluate alignment in transfemoral and knee-disarticulation prostheses.

  2. Effectiveness of a multidimensional home nurse led heart failure disease management program--a French nationwide time-series comparison.

    Science.gov (United States)

    Agrinier, Nelly; Altieri, Christelle; Alla, François; Jay, Nicolas; Dobre, Daniela; Thilly, Nathalie; Zannad, Faiez

    2013-10-09

    The purpose of this study was to assess the effectiveness of a disease management program (DMP) in heart failure (HF) on the incidence of HF hospitalizations and related costs in a real-world population-based setting. Insuffisance CArdiaque en LORraine (ICALOR), a DMP for HF was established in 2006 in the French region of Lorraine. Patients were enrolled after an index HF hospitalization. They received educational and home-visit monitoring programs by HF-trained nurses. General physicians received automatic alerts about patients' significant clinical or biological changes. We used the ICALOR and the national diagnostic related group databases to conduct a comparison of time-series trends in HF hospitalizations in France. The economic impact was obtained using the national scale of costs in France. The median age of the 1222 patients recruited before 2010 was 76 years, and 65% were male. Upon enrollment, patients essentially presented with NYHA class II (n=537, 48%) or class III (n=359, 32%) symptoms. One-year mortality rate was 20.3%. The implementation of the ICALOR program was associated with a reduction in HF hospitalizations in Lorraine estimated by an absolute difference between the number of hospitalizations observed in the Lorraine region and that expected had it been similar to that observed in the whole country of -7.19% in 2010. The estimated annual hospital cost saved by ICALOR was €1,927,648 in 2010. Coordinated DMP of HF might improve outcome cost-effectively when implemented in a real-world population setting, and was associated in Lorraine with a substantial modification of the trend of HF hospitalizations. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  3. Prioritizing Chemicals for Risk Assessment Using Chemoinformatics: Examples from the IARC Monographs on Pesticides.

    Science.gov (United States)

    Guha, Neela; Guyton, Kathryn Z; Loomis, Dana; Barupal, Dinesh Kumar

    2016-12-01

    Identifying cancer hazards is the first step towards cancer prevention. The International Agency for Research on Cancer (IARC) Monographs Programme, which has evaluated nearly 1,000 agents for their carcinogenic potential since 1971, typically selects agents for hazard identification on the basis of public nominations, expert advice, published data on carcinogenicity, and public health importance. Here, we present a novel and complementary strategy for identifying agents for hazard evaluation using chemoinformatics, database integration, and automated text mining. To inform selection among a broad range of pesticides nominated for evaluation, we identified and screened nearly 6,000 relevant chemical structures, after which we systematically compiled information on 980 pesticides, creating network maps that allowed cluster visualization by chemical similarity, pesticide class, and publicly available information concerning cancer epidemiology, cancer bioassays, and carcinogenic mechanisms. For the IARC Monograph meetings that took place in March and June 2015, this approach supported high-priority evaluation of glyphosate, malathion, parathion, tetrachlorvinphos, diazinon, p,p'-dichlorodiphenyltrichloroethane (DDT), lindane, and 2,4-dichlorophenoxyacetic acid (2,4-D). This systematic approach, accounting for chemical similarity and overlaying multiple data sources, can be used by risk assessors as well as by researchers to systematize, inform, and increase efficiency in selecting and prioritizing agents for hazard identification, risk assessment, regulation, or further investigation. This approach could be extended to an array of outcomes and agents, including occupational carcinogens, drugs, and foods. Citation: Guha N, Guyton KZ, Loomis D, Barupal DK. 2016. Prioritizing chemicals for risk assessment using chemoinformatics: examples from the IARC Monographs on Pesticides. Environ Health Perspect 124:1823-1829; http://dx.doi.org/10.1289/EHP186.

  4. Prioritizing Chemicals for Risk Assessment Using Chemoinformatics: Examples from the IARC Monographs on Pesticides

    Science.gov (United States)

    Guha, Neela; Guyton, Kathryn Z.; Loomis, Dana; Barupal, Dinesh Kumar

    2016-01-01

    Background: Identifying cancer hazards is the first step towards cancer prevention. The International Agency for Research on Cancer (IARC) Monographs Programme, which has evaluated nearly 1,000 agents for their carcinogenic potential since 1971, typically selects agents for hazard identification on the basis of public nominations, expert advice, published data on carcinogenicity, and public health importance. Objectives: Here, we present a novel and complementary strategy for identifying agents for hazard evaluation using chemoinformatics, database integration, and automated text mining. Discussion: To inform selection among a broad range of pesticides nominated for evaluation, we identified and screened nearly 6,000 relevant chemical structures, after which we systematically compiled information on 980 pesticides, creating network maps that allowed cluster visualization by chemical similarity, pesticide class, and publicly available information concerning cancer epidemiology, cancer bioassays, and carcinogenic mechanisms. For the IARC Monograph meetings that took place in March and June 2015, this approach supported high-priority evaluation of glyphosate, malathion, parathion, tetrachlorvinphos, diazinon, p,p′-dichlorodiphenyltrichloroethane (DDT), lindane, and 2,4-dichlorophenoxyacetic acid (2,4-D). Conclusions: This systematic approach, accounting for chemical similarity and overlaying multiple data sources, can be used by risk assessors as well as by researchers to systematize, inform, and increase efficiency in selecting and prioritizing agents for hazard identification, risk assessment, regulation, or further investigation. This approach could be extended to an array of outcomes and agents, including occupational carcinogens, drugs, and foods. Citation: Guha N, Guyton KZ, Loomis D, Barupal DK. 2016. Prioritizing chemicals for risk assessment using chemoinformatics: examples from the IARC Monographs on Pesticides. Environ Health Perspect 124:1823–1829;

  5. Le monde du theatre: monographie relative au montage d'une piece de theatre (The World of Theater: Monograph on Mounting a Theatrical Production).

    Science.gov (United States)

    Bokor, Pierre

    This monograph (in French) provides Alberta teachers with information relating to teaching about the world of the theater, and discusses the principal elements to be considered in mounting a theatrical production. It is intended for French language dramatic arts teachers (both in immersion courses and French-speaking schools). The monograph's four…

  6. A Review of the Multi-Authored Monograph “The Medical (Clinical Psychology Diagnosis: Current State and Prospects”

    Directory of Open Access Journals (Sweden)

    Vachkov I.V.

    2017-06-01

    Full Text Available The monograph presents a number of articles written by leading domestic clinical psychologists on various issues connected with psychological diagnosis. The multi-authored monograph was written for the international research-to-practice conference “The medical (clinical psychology diagnosis: tradition and prospects”. The conference took place in Moscow on November 29-30, 2016. The book consists of the following sections: "Research methodology in clinical psychology", “The development of endogenous mental pathology diagnosis current trends”, “The development of clinical psychology diagnostics current trends: age aspects”, “The main problems of clinical-psychological prevention and rehabilitation”. The materials of the monograph may be interesting and useful for scientists, psychology lecturers, students and post-graduate students, as well as for specialists working in the field of public health, education and social support for the population.

  7. Monograph support provided by the National Library of Medicine and its regional medical libraries in the medical behavioral sciences.

    Science.gov (United States)

    Saye, J D; Griffith, B C

    1988-01-01

    The National Library of Medicine's (NLM) monographic resources in the medical behavioral sciences (MBS) were examined to assess NLM's ability to support the needs of researchers writing in this area. A sample of 239 representative monographs derived from citations in MBS-related articles published in 61 journals in 1981 were evaluated. These monographs were limited to works published between 1978 and 1981, inclusive. The subject distribution of the sample included fourteen of the twenty-one main classes in the LC classification, although BF (psychology), H (social sciences), and R (medicine) constituted 80.3% of the sample. The study revealed that NLM held 48.5% of the sample. The holdings of ten research medical libraries, including six of the seven regional medical libraries, were also evaluated in order to gauge NLM's ability to support that element of the medical library network. The holding rates of these libraries ranged widely (9.6% to 36%), although NLM was found to have far more extensive holdings overall, and when assessed against classes BF, H, and R. Overall, NLM could have supplied from 28.8% to 44.5% of the monographs not held by the medical libraries. In only a few cases were the ten medical libraries able to provide access to monographs not held by NLM. The findings of the study indicate that, regardless of NLM's indication of support to the MBS area, the holdings of more general research and academic libraries are essential to support the monograph needs of MBS researchers. PMID:3224221

  8. TOWARDS A RATIONAL DESIGN FOR RESOLVING AGENTS .5. SUBSTITUENT EFFECTS IN THE RESOLUTION OF EPHEDRINE USING A SERIES OF CYCLIC PHOSPHORIC-ACIDS

    NARCIS (Netherlands)

    VANDERHAEST, AD; WYNBERG, H; LEUSEN, FJJ; BRUGGINK, A

    1993-01-01

    The effects of various aromatic substituents in both ephedrine and a cyclic phosphoric acid on the quality of resolution via diastereomeric salt formation are investigated. The diastereoselective synthesis of a novel series of chloro-substituted ephedrines is described. These chloroephedrines can be

  9. Effective dose scaling factors for use with uranium series cascade impactor data: a reassessment using the IMBA code.

    Science.gov (United States)

    Kim, Kwang Pyo; Wu, Chang-Yu; Birky, Brian K; Bolch, Wesley E

    2006-10-01

    Air sampling with a multi-stage cascade impactor enables one to assess airborne radioactivity as a function of particle size, significantly enhancing the accuracy of the dose assessment. The application of cascade sampling data to inhalation dose assessments can require more computational effort if something other than a mono-sized distribution per impactor stage is to be considered. To overcome this limitation, Kim et al. (Health Phys 89:359-374; 2005) introduced the concept of an effective dose scaling factor SF(E) enabling one to consider more realistic impactor stage radioactivity distributions (uniform, linearly decreasing, or linearly increasing variations with particle size). The SF(E) is the ratio of the effective dose given under a uniform or linearly changing radioactivity distribution across the particle size interval to that given for a mono-sized radioactivity distribution for the same impactor stage. The latter approach can initially be used (which requires less computational effort) followed by a rescaling of the effective dose either upward or downward by the SF(E) value. In this earlier study, the LUDEP code was employed which utilizes the ICRP 66 human respiratory tract model along the radionuclide biokinetic models given in ICRP Publication 30. In the present study, inhalation dose coefficients and effective dose scaling factors were reexamined for several radionuclides of the (238)U series using the IMBA program, which employs more recent and physiologically realistic biokinetic models published by the ICRP. An update of the effective dose scaling factors is thus the primary focus of this study rather than an extensive inter-comparison of the IMBA and LUDEP codes. Inhalation dose coefficients calculated by the two programs differ by up to a factor of 5 for Type F (238)U and (234)U, but are within only 2% of each other for Type S radionuclides. The ICRP 69 biokinetic model of uranium predicts retention in bone and kidneys that is slightly higher

  10. The effect of the late 2000s financial crisis on suicides in Spain: an interrupted time-series analysis.

    Science.gov (United States)

    Lopez Bernal, James A; Gasparrini, Antonio; Artundo, Carlos M; McKee, Martin

    2013-10-01

    The current financial crisis is having a major impact on European economies, especially that of Spain. Past evidence suggests that adverse macro-economic conditions exacerbate mental illness, but evidence from the current crisis is limited. This study analyses the association between the financial crisis and suicide rates in Spain. An interrupted time-series analysis of national suicides data between 2005 and 2010 was used to establish whether there has been any deviation in the underlying trend in suicide rates associated with the financial crisis. Segmented regression with a seasonally adjusted quasi-Poisson model was used for the analysis. Stratified analyses were performed to establish whether the effect of the crisis on suicides varied by region, sex and age group. The mean monthly suicide rate in Spain during the study period was 0.61 per 100 000 with an underlying trend of a 0.3% decrease per month. We found an 8.0% increase in the suicide rate above this underlying trend since the financial crisis (95% CI: 1.009-1.156; P = 0.03); this was robust to sensitivity analysis. A control analysis showed no change in deaths from accidental falls associated with the crisis. Stratified analyses suggested that the association between the crisis and suicide rates is greatest in the Mediterranean and Northern areas, in males and amongst those of working age. The financial crisis in Spain has been associated with a relative increase in suicides. Males and those of working age may be at particular risk of suicide associated with the crisis and may benefit from targeted interventions.

  11. Is sustained natural apophyseal glides combined with conventional physiotherapy effective for patients with facet joint syndrome? – A case series

    Directory of Open Access Journals (Sweden)

    Deepak B. Anap, Subhash Khatri, Zambre BR

    2014-11-01

    Full Text Available Background: Chronic back pain has been the nemesis of the human race since the time they evolved and began walking on their two legs; leaving aside the 4 limb locomotion of their predecessors. Varied are the causes of low back ache and facet joint syndrome is one amongst them. Hence this study was undertaken to find out the effectiveness of SNAGS and conventional physiotherapy in patients with lumbar facet joint syndrome. Purpose: To describe the management and outcomes of 4 patients with lumbar facet joint syndrome treated with Sustained Natural apophyseal glides (SNAGs, Therapeutic Ultrasound and lumbar stabilization exercises. Study Design : A case series of consecutive patients with Lumbar facet syndrome Case Description: Four consecutive patients (mean age 52 years who presented with lumbar facet syndrome were treated with two weeks protocol which included Sustained Natural apophyseal glides, Therapeutic Ultrasound (Cont. 1-MHz , 2.0-W/cm2, 10min and lumbar stabilization exercises. Follow up was taken 1 week after the end of active intervention. All patients completed Visual analogue Scale (VAS, Modified Oswestery Disability Questionnaire (MODQ, Sorensen Test hold Timing and spinal Range of motion on initial assessment, immediately at the end of active intervention (2 weeks and at the end of follow up. Outcome: All four patients showed the mean percentage change in score of VAS 49.87 %, MODQ 61.14 %, Sorensen test scores 19.63 %, Flexion range 9.21 % and extend range 17.07 % at the end of follow up. Conclusion: All four patients with Lumbar facet joint syndrome treated with sustained natural apophyseal glides (SNAGS, Therapeutic Ultrasound and lumbar stabilisation exercises exhibited reduced pain, reduced disability, improved endurance of back muscles and range of motion at the time follow-up.

  12. DEVELOPMENT OF METHOD OF QUALITATIVE ANALYSIS OF BIRD CHERRY FRUIT FOR INCLUSION IN THE MONOGRAPH OF STATE PHARMACOPOEIA OF UKRAINE

    Directory of Open Access Journals (Sweden)

    Lenchyk L.V.

    2016-06-01

    Full Text Available Introduction. Bird cherry Padus avium Mill, Rosaceae, is widespread in Ukraine, especially in forests and forest-steppe areas. Bird cherry fruits have long been used in medicine and is a valuable medicinal raw materials. They stated to posess astringent, anti-inflammatory, phytoncidal properties. Bird cherry fruits are included in the USSR Pharmacopoeia IX ed., The State Pharmacopoeia of the Russian Federation, The State Pharmacopoeia of Republic of Belarus. In Ukraine there are no contemporary normative documents for this medicinal plant material, therefore it is the actual to develop projects in the national monographs "dry bird cherry fruit" and "fresh bird cherry fruit" to be included in the State Pharmacopoeia of Ukraine. According to European Pharmacopoeia recommendation method of thin-layer chromatography (TLC is prescribed only for the identification of the herbal drug. The principles of thin-layer chromatography and application of the technique in pharmaceutical analysis are described in State Pharmacopoeia of Ukraine. As it is effective and easy to perform, and the equipment required is inexpensive, the technique is frequently used for evaluating medicinal plant materials and their preparations. The TLC is aimed at elucidating the chromatogram of the drug with respect to selected reference compounds that are described for inclusion as reagents. Aim of this study was to develop methods of qualitative analysis of bird cherry fruits for a monograph in the State Pharmacopoeia of Ukraine (SPU. Materials and Methods. The object of our study was dried bird cherry fruits (7 samples and fresh bird cherry fruits (7 samples harvested in 2013-2015 in Kharkiv, Poltava, Luhansk, Sumy, Lviv, Mykolaiv regions and the city Mariupol. Samples were registered in the department of SPU State Enterprise "Pharmacopeia center". In accordance with the Ph. Eur. and SPU requirements in "identification C" determination was performed by TLC. TLC was performed on

  13. Biowaiver monographs for immediate release solid oral dosage forms: ibuprofen.

    Science.gov (United States)

    Potthast, H; Dressman, J B; Junginger, H E; Midha, K K; Oeser, H; Shah, V P; Vogelpoel, H; Barends, D M

    2005-10-01

    Literature data are reviewed on the properties of ibuprofen related to the biopharmaceutics classification system (BCS). Ibuprofen was assessed to be a BCS class II drug. Differences in composition and/or manufacturing procedures were reported to have an effect on the rate, but not the extent of absorption; such differences are likely to be detectable by comparative in vitro dissolution tests. Also in view of its therapeutic use, its wide therapeutic index and uncomplicated pharmacokinetic properties, a biowaiver for immediate release (IR) ibuprofen solid oral drug products is scientifically justified, provided that the test product contains only those excipients reported in this paper in their usual amounts, the dosage form is rapidly dissolving (85% in 30 min or less) in buffer pH 6.8 and the test product also exhibits similar dissolution profiles to the reference product in buffer pH 1.2, 4.5, and 6.8.

  14. Bibliometric analysis of martial arts monographs published in Spain (1906-2006

    Directory of Open Access Journals (Sweden)

    Mikel Pérez Gutiérrez

    2012-07-01

    Full Text Available This paper examines the martial arts monographs published in Spain between 1906 and 2006 from a bibliometric point of view. Starting from Pérez and Gutiérrez’s previous bibliography (2008, the total number of published monographs following the criteria of subject, decade and the combination of both was analyzed. The results showed a total of 2.036 books (1.285 original editions with a prevalence of Japanese and Chinese martial arts. A group of eight subjects exceeded a hundred volumes (karate, judo/jujutsu, taijiquan, wu-shu/kung fu, classics, qigong, philosophy, history and education, and aikido, with two patterns of bibliographic evolution appearing. The first, represented by Japanese martial arts considered as a group and martial arts focused on the utilitarian and/or sporting performance aspects (judo/jujutsu, karate and wu-shu/kung fu, developed increasingly until the 80’s when it followed a steady-state and/or drop. The second model, which characterises the Chinese martial arts group and martial arts mainly focused on healthy and/or spiritual aspects of training (taijiquan, qigong, aikido, has increased significantly from the 90’s until the present moment. The interpretation of these patterns and the evolution of the martial arts bibliographic production in Spain highlights some aspects such as the development of the Spanish society and sports practice, bibliographic production, reading habits, or the cultural influences of eastern countries on Spain.

  15. 浅议海洋科技专著中地图的规范化%Map Standardization in Marine Technology Monograph

    Institute of Scientific and Technical Information of China (English)

    白燕; 彭珺

    2014-01-01

    The existing problems of maps are discussed and analyzed. It is believed that maps should meet the requirements of self -evident, abstract and simplistic. As for the map name, line graphs, and image maps, the suggestions of map standardization are proposed to improve maps' information transfer functions and visual effects in marine technology monographs.%讨论分析了目前海洋科技专著中地图所存在的问题,提出了地图应符合自明性、抽象性和简明性的要求,并针对图名、线划图和影像图提出地图制作的规范化建议,以便增强地图在海洋科技专著中的信息传递功能和视觉效果。

  16. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin.

    Science.gov (United States)

    Goodarzi, Navid; Barazesh Morgani, Ahmadreza; Abrahamsson, Bertil; Cristofoletti, Rodrigo; Groot, D W; Langguth, Peter; Mehta, Mehul U; Polli, James E; Shah, Vinod P; Dressman, Jennifer B

    2016-04-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release solid oral dosage forms containing ribavirin are reviewed. Ribavirin is highly soluble, but its permeability characteristics are not well defined. Therefore according to the Biopharmaceutical Classification System, and taking a "worst case" approach, ribavirin should be assigned to class III. As ribavirin is transported across the brush border membrane of the human jejunum by hCNT2, it shows saturable uptake in the intestine. However, no common excipients have been shown to compete for ribavirin absorption, nor have problems with BE of immediate release ribavirin formulations containing different excipients and produced by different manufacturing methods been reported in the open literature. So the risk of bioinequivalence caused by these factors appears to be low. Ribavirin is considered a narrow therapeutic index drug, as judged by comparing the minimum effective concentration and minimum toxic concentrations in blood. Although ribavirin would not be eligible for approval via a Biopharmaceutical Classification System-based biowaiver procedure according to today's guidances due to its narrow therapeutic index, the risks of biowaiving should be weighed against the considerable risks associated with studying BE of ribavirin products in healthy subjects.

  17. Evaluation of the Effects of Hofmeister Series on Salting Out in the Determination of Organophosphorous Pesticides and Pyrethroids by LDS/DLLME

    OpenAIRE

    Noronha,Luiz M. S.; Neves,Antonio A.; Queiroz,Maria E. L. R. de; Oliveira,André F. de

    2015-01-01

    Various greener microextraction procedures have been proposed with low limits of detection to control of pesticides present in the environment, including the low-density solvent dispersive liquid‑liquid microextraction (LDS/DLLME) technique. The addition of electrolytes is important in order to induce the salting-out effect. Thus, it is possible to use the Hofmeister series and the Voet lyotropic number to study the effect of different ions on pesticide extraction in LDS/DLLME technique...

  18. There’s alcohol in my soap: portrayal and effects of alcohol use in a popular television series

    NARCIS (Netherlands)

    Hoof, van Joris J.; Jong, de Menno D.T.; Fennis, Bob M.; Gosselt, Jordy F.

    2009-01-01

    Two studies are reported addressing the media influences on adolescents’ alcohol-related attitudes and behaviours. A content analysis was conducted to investigate the prevalence of alcohol portrayal in a Dutch soap series. The coding scheme covered the alcohol consumption per soap character, drinkin

  19. THE LEVERAGE EFFECT AND THE ASYMMETRY OF THE ERROR DISTRIBUTION IN GARCH-BASED MODELS: THE CASE OF BRAZILIAN MARKET RELATED SERIES

    Directory of Open Access Journals (Sweden)

    Daniel de Almeida

    2014-05-01

    Full Text Available Traditional GARCH models fail to explain at least two of the stylized facts found in financial series: the asymmetry of the distribution of errors and the leverage effect. The leverage effect stems from the fact that losses have a greater influence on future volatilities than do gains. Asymmetry means that the distribution of losses has a heavier tail than the distribution of gains. We test whether these features are present in some series related to the Brazilian market. To test for the presence of these features, the series were fitted by GARCH(1,1, TGARCH(1,1, EGARCH(1,1, and GJR-GARCH(1,1 models with standardized Student t distribution errors with and without asymmetry. Information criteria and statistical tests of the significance of the symmetry and leverage parameters are used to compare the models. The estimates of the VaR (value-at-risk are also used in the comparison. The conclusion is that both stylized facts are present in some series, mostly simultaneously.

  20. The short-term effects of air pollutants on respiratory disease mortality in Wuhan, China: comparison of time-series and case-crossover analyses

    Science.gov (United States)

    Ren, Meng; Li, Na; Wang, Zhan; Liu, Yisi; Chen, Xi; Chu, Yuanyuan; Li, Xiangyu; Zhu, Zhongmin; Tian, Liqiao; Xiang, Hao

    2017-01-01

    Few studies have compared different methods when exploring the short-term effects of air pollutants on respiratory disease mortality in Wuhan, China. This study assesses the association between air pollutants and respiratory disease mortality with both time-series and time-stratified–case-crossover designs. The generalized additive model (GAM) and the conditional logistic regression model were used to assess the short-term effects of air pollutants on respiratory disease mortality. Stratified analyses were performed by age, sex, and diseases. A 10 μg/m3 increment in SO2 level was associated with an increase in relative risk for all respiratory disease mortality of 2.4% and 1.9% in the case-crossover and time-series analyses in single pollutant models, respectively. Strong evidence of an association between NO2 and daily respiratory disease mortality among men or people older than 65 years was found in the case-crossover study. There was a positive association between air pollutants and respiratory disease mortality in Wuhan, China. Both time-series and case-crossover analyses consistently reveal the association between three air pollutants and respiratory disease mortality. The estimates of association between air pollution and respiratory disease mortality from the case–crossover analysis displayed greater variation than that from the time-series analysis.

  1. Effects of myofascial trigger point dry needling in patients with sleep bruxism and temporomandibular disorders: a prospective case series.

    Science.gov (United States)

    Blasco-Bonora, Paloma María; Martín-Pintado-Zugasti, Aitor

    2017-03-01

    To investigate the effects of deep dry needling (DN) of myofascial trigger points (MTrPs) of the masseter and temporalis on pain, pressure pain threshold (PPT), pain-free maximal jaw opening and temporomandibular disorder (TMD)-related disability in patients with sleep bruxism (SB) and myofascial TMD. Seventeen subjects (11 women, 6 men) aged 39±13 years (range 23-66) diagnosed with SB and myofascial TMD were invited to participate in this prospective case series study. Each subject received a deep DN intervention in the masseter and temporalis MTrPs. Pain intensity, PPT, pain-free maximal jaw opening and TMD-related disability were assessed before treatment, immediately after treatment and at 1-week follow-up. Jaw disability was assessed using the jaw disability checklist (JDC) at baseline and 1 week post-treatment only. One-way analyses of variance showed significant improvements in pain intensity, PPT and jaw opening (ppoints in pain (immediate: Cohen's d=1.72, p<0.001; 1 week: d=3.24, p<0.001), jaw opening (immediate: d=0.77, p<0.001; 1 week: d=1.02, p<0.001) and PPT in the masseter (immediate: d=1.02, p<0.001; 1 week: d=1.64, p<0.001) and temporalis (immediate: d=0.91, p=0.006; 1 week: d=1.8, p<0.001). A dependent t-test showed a significant improvement in jaw functioning, reflected by a large reduction in 1-week JDC scores relative to baseline (d=3.15, p<0.001). Deep DN of active MTrPs in the masseter and temporalis in patients with myofascial TMD and SB was associated with immediate and 1-week improvements in pain, sensitivity, jaw opening and TMD-related disability. NCT02587182; Results. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  2. Fundamentos Basicos de Career Education. Monografia en Career Education. [Basic Fundamentals of Career Education. Monograph in Career Education].

    Science.gov (United States)

    Office of Education (DHEW), Washington, DC.

    This document is the Spanish translation of ED 145 222, A Primer for Career Education. In this monograph, a view of the basic nature of the career education effort is discussed under the following topics: the basis of need for career education; the meaning and goals of career education; the difference between career education and vocational…

  3. Suitability of a liquid chromatography assay of neomycin sulfate to replace the microbiological assay for neomycin in USP Monographs.

    Science.gov (United States)

    Hanko, Valoran P; Rohrer, Jeffrey S

    2010-01-01

    The current USP National Formulary contains 65 Monographs for drug formulations containing neomycin. All 65 Monographs prescribe a bioassay for neomycin assay. This bioassay, based on cell culture, is labor intensive, has poor precision, and cannot be adapted for purity or identification. High-performance anion-exchange chromatography with integrated pulsed amperometric detection (HPAE-IPAD), a liquid chromatography technique, has been shown to be suitable for neomycin purity analysis and neomycin assay of an over-the-counter first aid cream (Hanko and Rohrer [17]). Here we propose that an HPAE-IPAD assay can replace the bioassay in the 65 neomycin-containing Monographs. We applied the HPAE-IPAD assay to four neomycin-containing drug products representing the four classes of formulations found in the 65 Monographs, liquid, solid, suspension, and cream. Each drug was analyzed with two chromatography systems, and on 3 separate days. For all products, HPAE-IPAD measurements were precise and accurate with respect to the label concentrations. There was also high accuracy for spike recovery of neomycin from the four drug products throughout 70-150% of the labeled concentration. These results suggest that an HPAE-IPAD assay would be an accurate assay for neomycin, and would be faster and more precise than the current bioassay.

  4. Access to Elementary Education in India: Politics, Policies and Progress. CREATE Pathways to Access. Research Monograph No. 44

    Science.gov (United States)

    Little, Angela W.

    2010-01-01

    This monograph examines progress in, and policies for, access to elementary education over the past 60 years, the role played by political factors in the process of policy formulation and implementation and the drivers and inhibitors of the implementation of reforms in elementary education in recent years in India. Drawing on interviews and…

  5. Value Orientations of Vietnamese Culture. Cultural Monograph No. 3. Bilingual Multicultural Education Training Project for School Psychologists and Guidance Counselors.

    Science.gov (United States)

    Hallman, Clemens L.; And Others

    This teacher training monograph deals with value orientations of cultures in general with specific reference to Vietnamese culture. The first two sections discuss the conceptual issues of value orientation and give axiological definitions of the six clusters used to describe cultural orientation. The third section introduces the section on…

  6. Social Development: Self Help Skills. A Performance-Based Early Childhood-Special Education Teacher Preparation Program. Monograph 13.

    Science.gov (United States)

    Mann, Lynne

    This monograph presents the self-help skills module of the social development curriculum portion of the Early Childhood-Special Education Teacher Preparation Program. Included are: (1) an ontogeny of self-help skills (feeding, dressing, toileting, and grooming) in young children; (2) a brief discussion of the relevance of self-help skills to the…

  7. [Knowledge of German neurologists on migraine around 1890. Paul Julius Möbius and his 1894 monograph Die Migräne].

    Science.gov (United States)

    Schobeß, C; Steinberg, H

    2013-08-01

    Paul Julius Möbius (1853-1907), a Leipzig-based author and editor on a vast majority of subjects, has often been acknowledged as a leading 19th-century German neurologist. His impact on the development of knowledge on migraine has likewise been pointed to. This study compares the monograph published by Möbius on the illness in 1894 with contemporary publications and with present day best practice to establish if the author really made an essential contribution to the problem of migraine. As a representative of the central theory Möbius assumed that migraine was caused by aberrations in the brain. At the same time he made it clear that due to very limited diagnostic options this was only a hypothesis. Apart from a genetic factor and these cerebral changes, for Möbius the general state of health was a decisive factor and prevention and change in lifestyle therefore played a crucial role in his therapeutic recommendations. Basically there were only few differences between the views of Möbius and his colleagues, the major dissimilarity being that Möbius postulated a merely suggestive impact but no physical effect of electrotherapy. Although Möbius's monograph on migraine lacks originality, it provides a concise, easy to understand and stylistically impressive overview on the state of knowledge at that time. Therefore, the book can be considered as a benchmark publication of German speaking neurology around 1890 on migraine and it is highly recommended to present day headache and migraine researchers as well as historians of psychiatry and neurology.

  8. 清代中前期饮食专著的编撰研究%On the Diet Monographs of the Early and Middle Qing Dynasty

    Institute of Scientific and Technical Information of China (English)

    孙铁楠

    2012-01-01

    饮食是人类赖以生存发展的重要因素。如何解决好饮食问题,涉及到社会的政治、经济、文化等多方面的内容。我国很早就有关于饮食方面的书籍,清代中前期饮食文献是我国古代饮食文献发展的最高阶段,它不仅对前代饮食进行了总结,使饮食文献内容更加丰富,而且对近现代饮食文献的发展和完善也产生积极的作用。在数目众多的清代饮食文献中,饮食专著文献不仅是清代饮食文献的主体,而且最能体现这一时期所取得的成就。目前学术界对于清代中前期饮食专著文献的研究是比较薄弱的。专门对清代中前期饮食文献方面的研究,虽然有对于某一本著作进行研究的论文,但是缺少从总体上进行分析探讨。因此,从历史文献学角度研究清代中前期饮食专著文献是十分必要的。%Diet is an important factor in the survival and development of human beings. How to have a healthy diet involves many aspects including politics, economy, and culture. China had books on diet quite long time ago. The early and middle period of Qing Dynasty reached the highest stage of development of China's ancient diet literature, which not only summarized the previous generations' diet literature, but also enriched their contents and had a positive effect on the development of modern diet literature. Diet monographs account for a crucial part among the numerous culinary literatures in Qing Dynasty, and they can best embody the achievements of this period. However, the study of diet monographs of the early and middle period of Qing Dynasty is relatively weak. Although there are papers researching on some of those monographs, overall analysis and discussion are insufficient. Therefore, it is very necessary to study the diet monographs of the early and middle period of Qing Dynasty from the point of historical literature view.

  9. Effects of fractional crystallization and cumulus processes on mineral composition trends of some lunar and terrestrial rock series

    Science.gov (United States)

    Longhi, J.

    1982-01-01

    A plot of Mg of mafic minerals versus An of plagioclase in cumulate rocks from various lunar and terrestrial rock series shows each series to have a distinct curvilinear trend. The slopes of these trends vary from nearly vertical in the case of lunar anorthosites and Mg-norites to nearly horizontal in the case of gabbros from the mid-Atlantic ridge. Calculations based upon known major element partitioning between mafic minerals, plagioclase and subalkaline basaltic liquids indicate that fractional crystallization coupled with cotectic accumulation of mafic minerals and plagioclase will produce mineral composition trends on the Mg versus An diagram with slopes greater than 1 for cases where An is approximately greater than Mg. Furthermore, fractional crystallization of basaltic magmas with alkali concentrations approaching zero will produce near vertical Mg versus An trends. Therefore, the steep slopes of the lunar rock series are consistent with relatively simple fractionation processes. The relatively flat slope of mineral compositions from gabbros collected from the mid-Atlantic ridge at 26 deg N is inconsistent with simple fractionation processes, and calculations show that periodic refilling of a fractionating magma chamber with picritic magma cannot simply explain this flat slope either.

  10. LETTER TO THE EDITOR: A comparison of the effect of pressure and Co substitution on the Néel temperature of the ? series

    Science.gov (United States)

    Bud'ko, S. L.; Demishev, G. B.; Fontes, M. B.; Baggio-Saitovitch, E.

    1996-03-01

    The effect of hydrostatic pressure and alloying on the magnetic ordering temperature in the 0953-8984/8/11/001/img8 series was studied. The observed behaviour was related to changes in the density of states at the Fermi level caused by pressure or Ni substitution. In addition, the elastic constants of 0953-8984/8/11/001/img9, which is a representative member of the 0953-8984/8/11/001/img10 family, were measured.

  11. Data Matching, Integration, and Interoperability for a Metric Assessment of Monographs

    DEFF Research Database (Denmark)

    Zuccala, Alesia Ann; Cornacchia, Roberto

    2016-01-01

    in a new Microsoft SQL database. The purpose of the experiment was to investigate co-varied metrics for a list of book titles based on their citation impact (from Scopus), presence in international libraries (WorldCat.org) and visibility as publically reviewed items (Goodreads). The results of our data......This paper details a unique data experiment carried out at the University of Amsterdam, Center for Digital Humanities. Data pertaining to monographs were collected from three autonomous resources, the Scopus Journal Index, WorldCat.org and Goodreads, and linked according to unique identifiers...... experiment highlighted current problems related citation indices and the way that books are recorded by different citing authors. Our research further demonstrates the primary problem of matching book titles as ‘cited objects’ with book titles held in a union library catalog, given that books are always...

  12. Causality between time series

    CERN Document Server

    Liang, X San

    2014-01-01

    Given two time series, can one tell, in a rigorous and quantitative way, the cause and effect between them? Based on a recently rigorized physical notion namely information flow, we arrive at a concise formula and give this challenging question, which is of wide concern in different disciplines, a positive answer. Here causality is measured by the time rate of change of information flowing from one series, say, X2, to another, X1. The measure is asymmetric between the two parties and, particularly, if the process underlying X1 does not depend on X2, then the resulting causality from X2 to X1 vanishes. The formula is tight in form, involving only the commonly used statistics, sample covariances. It has been validated with touchstone series purportedly generated with one-way causality. It has also been applied to the investigation of real world problems; an example presented here is the cause-effect relation between two climate modes, El Ni\\~no and Indian Ocean Dipole, which have been linked to the hazards in f...

  13. Ordered mesoporous carbon film as an effective solid-phase microextraction coating for determination of benzene series from aqueous media.

    Science.gov (United States)

    Jiang, Hui; Li, Jiansheng; Jiang, Mingyue; Lu, Rui; Shen, Jinyou; Sun, Xiuyun; Han, Weiqing; Wang, Lianjun

    2015-08-12

    The present work reports preparation of ordered mesoporous carbon (OMC) film supported on a graphite fiber as a new type of solid-phase microextraction (SPME) fiber for determination of benzene series from aqueous media. The strategy for the supported OMC film preparation was combined dip-coating technology with solvent evaporation-induced self-assembly (EISA) approach. A graphite fiber was immersed in an ethanol solution containing phenolic resin and Pluronic triblock copolymer. Upon solvent evaporation and subsequent pyrolysis under 700 °C, the phenolic resin and the surfactant self-assembled on the surface of the graphite fiber to form smooth OMC film. X-ray diffraction (XRD), transmission electron microscopy (TEM) and nitrogen isothermal adsorption results indicate that the resultant OMC film possesses well-ordered two dimensional hexagonal mesostructure with pore diameters of 4.5 nm and BET surfaces of 630 m(2)/g. Scanning electron microscopy (SEM) studies show the supported OMC film with thickness at 8.5 μm is continuous and defect-free. The SPME efficiency of the OMC fiber was evaluated by analysis of five benzene series (benzene, toluene, ethylbenzene, p-xylene and m-xylene) from water samples by gas chromatography-flame ionization detection (GC-FID). The analysis results indicate that the prepared OMC fiber has wide linear ranges (0.5-500 μg/L), low detection limits (0.01-0.05 μg/L) and good repeatabilities (4.0-5.8% for one fiber, 2.9-8.7% for fiber-to-fiber). Compared with commercial counterparts, the OMC fiber exhibits improved extraction efficiency for benzene series and PAHs. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. Magnetocaloric effect of a series of remarkably isostructural intermetallic [Ni(II)3Ln(III)] cubane aggregates.

    Science.gov (United States)

    Wang, Pei; Shannigrahi, Santiranjan; Yakovlev, Nikolai L; Hor, T S Andy

    2014-01-07

    A new series of remarkably isostructural 3d-4f compounds, [Ni3Ln(hmp)4(OAc)5]·H2O·CH2Cl2 (Ln = Gd (1), Tb (2), Dy (3), Ho (4), Y (5)) were synthesized based on a simple one-pot self-assembly method. Magnetic measurements demonstrated the ferromagnetic property of the [Ni3Ln] cores and the heterometallic influence on the magnetocaloric properties. This study suggested that robust and discrete intermetallic cubanes can be an alternative to other magnetically active materials such as high-nuclearity aggregates or clusters whose structures are not generally controlled by common synthetic methodological designs.

  15. Ordered mesoporous carbon film as an effective solid-phase microextraction coating for determination of benzene series from aqueous media

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Hui [Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094 (China); School of Geography Science, Nantong University, Nantong 226001 (China); Li, Jiansheng, E-mail: lijsh@mail.njust.edu.cn [Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094 (China); Jiang, Mingyue; Lu, Rui; Shen, Jinyou; Sun, Xiuyun; Han, Weiqing [Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094 (China); Wang, Lianjun, E-mail: wanglj@mail.njust.edu.cn [Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094 (China)

    2015-08-12

    The present work reports preparation of ordered mesoporous carbon (OMC) film supported on a graphite fiber as a new type of solid-phase microextraction (SPME) fiber for determination of benzene series from aqueous media. The strategy for the supported OMC film preparation was combined dip-coating technology with solvent evaporation-induced self-assembly (EISA) approach. A graphite fiber was immersed in an ethanol solution containing phenolic resin and Pluronic triblock copolymer. Upon solvent evaporation and subsequent pyrolysis under 700 °C, the phenolic resin and the surfactant self-assembled on the surface of the graphite fiber to form smooth OMC film. X-ray diffraction (XRD), transmission electron microscopy (TEM) and nitrogen isothermal adsorption results indicate that the resultant OMC film possesses well-ordered two dimensional hexagonal mesostructure with pore diameters of 4.5 nm and BET surfaces of 630 m{sup 2}/g. Scanning electron microscopy (SEM) studies show the supported OMC film with thickness at 8.5 μm is continuous and defect-free. The SPME efficiency of the OMC fiber was evaluated by analysis of five benzene series (benzene, toluene, ethylbenzene, p-xylene and m-xylene) from water samples by gas chromatography-flame ionization detection (GC-FID). The analysis results indicate that the prepared OMC fiber has wide linear ranges (0.5–500 μg/L), low detection limits (0.01–0.05 μg/L) and good repeatabilities (4.0–5.8% for one fiber, 2.9–8.7% for fiber-to-fiber). Compared with commercial counterparts, the OMC fiber exhibits improved extraction efficiency for benzene series and PAHs. - Highlights: • Ordered mesoporous carbon film supported on graphite fiber was first reported as solid-phase microextraction coating. • The strategy for the film preparation was combined dip-coating technology with evaporation-induced self-assembly approach. • The obtained fiber showed enhanced thermal stability and organic solvents resistance. • The

  16. More About Trigonometric Series and Integration

    OpenAIRE

    Bullen, P. S.

    2003-01-01

    In this paper the discussion of the effect of trigonometric series on the theory of integration is continued from an earlier paper by Gluchoff, Trigonometric series and theories of integration, Math.Mag., 67 (1994), 3--20.

  17. Investigation of the effect of the hyperparameter optimization and the time lag selection in time series forecasting using machine learning algorithms

    Science.gov (United States)

    Papacharalampous, Georgia; Tyralis, Hristos; Koutsoyiannis, Demetris

    2017-04-01

    The hyperparameter optimization and the time lag selection are considered to be of great importance in time series forecasting using machine learning (ML) algorithms. To investigate their effect on the ML forecasting performance we conduct several large-scale simulation experiments. Within each of the latter we compare 12 methods on 2 000 simulated time series from the family of Autoregressive Fractionally Integrated Moving Average (ARFIMA) models. The methods are defined by the set {ML algorithm, hyperparameter selection procedure, time lags}. We compare three ML algorithms, i.e. Neural Networks (NN), Random Forests (RF) and Support Vector Machines (SVM), two procedures for hyperparameter selection i.e. predefined hyperparameters or defined after optimization and two regression matrices (using time lag 1 or 1, …, 21). After splitting each simulated time series into a fitting and a testing set, we fit the models to the former set and compare their performance on the latter one. We quantify the methods' performance using several metrics proposed in the literature and benchmark methods. Furthermore, we conduct a sensitivity analysis on the length of the fitting set to examine how it affects the robustness of our results. The findings indicate that the hyperparameter optimization mostly has a small effect on the forecasting performance. This is particularly important, because the hyperparameter optimization is computationally intensive. On the other hand, the time lag selection seems to mostly significantly affect the methods performance when using the NN algorithm, while we observe a similar behaviour for the RF algorithm albeit to a smaller extent.

  18. Forecasting of monthly inflow and outflow currency using time series regression and ARIMAX: The Idul Fitri effect

    Science.gov (United States)

    Ahmad, Imam Safawi; Setiawan, Suhartono, Masun, Nunun Hilyatul

    2015-12-01

    Currency plays an important role in economic transactions of Indonesian society. In order to guarantee the availability of currency, Bank Indonesia needs to develop demand and supply planning of currency. The purpose of this study is to get model and predict inflow and outflow of currency in KPW BI Region IV (East Java) with ARIMA method, time series regression and ARIMAX. The data of monthly inflow and outflow is used of currency in KPW BI Surabaya, Malang, Kediri and Jember.The observation period starting from January 2003 to December 2014. Based on the smallest values of out-sample RMSE and SMAPE, ARIMA is the best model to predict the outflow of currency in KPW BI Surabaya and ARIMAX for KPW BI Malang, Kediri and Jember. The best forecasting model for inflow of currency in KPW BI Surabaya, Malang, Kediri and Jember chronologically as follows are calendar variation model, transfer function, ARIMA, and time series regression. These results indicates that the more complex models may not necessarily produce a more accurate forecast as the result of M3-Competition.

  19. Effects of a powered ankle-foot prosthesis on kinetic loading of the contralateral limb: a case series.

    Science.gov (United States)

    Hill, David; Herr, Hugh

    2013-06-01

    Lower-extremity amputees encounter a series of stress-related challenges. Among them is an increased risk of chronic joint disorders. For unilateral, transtibial amputees, we hypothesize that increasing the power output of the trailing, ankle-foot prosthesis during powered plantar flexion could mitigate kinetic loading applied to the leading, contralateral leg during walking. Here, we present a case series that analyzes kinetic factors of unilateral, transtibial amputee gait and forms a comparison between two types of ankle prostheses with varying power outputs. The factors examined here are impact resultant force, peak foot pressure at heel-strike, step-to-step transition work, and knee external adduction moment. The two prostheses are the amputee participant's daily-use passive ankle-foot prosthesis and the BiOM powered ankle-foot prosthesis capable of biologically accurate powered plantar flexion during late stance. In a preliminary study on two transtibial amputees walking over level terrain at a controlled speed (1.25 m/s), we observed average reductions of 8% in peak impact resultant force, 18% in impact resultant force loading rate, 8% in peak heel-strike foot pressure, and 15% in the 1(st) peak knee external adduction moment when the powered ankle-foot prosthesis was compared to the conventional passive prosthesis. Overall, our preliminary results suggest that more biomimetic prosthetic ankle-foot push-off during late stance may limit leading-leg musculoskeletal stress in walking.

  20. EFFECTIVE SPECIFIC ACTIVITY OF NATURAL RADIONUCLIDES FOR THE NORM BELONGED TO 238U AND 232TH SERIES BEING IN THE STATE OF DISTURBED RADIOACTIVE EQUILIBRIUM

    Directory of Open Access Journals (Sweden)

    I. P. Stamat

    2008-01-01

    Full Text Available In the Sanitary Rules SR 2.6.1.1292-03 and SR 2.6.6.1169-02 classification of the industrial waste containing naturally occurring radioactive materials is adopted in accordance to the values of their effective specific activity Aeff. In a case of the disturbed equilibrium in 238U and 232Th series it is necessary to take into consideration actual contribution of the separate natural radionuclides of the mentioned series into the value of gamma dose rate of the waste. This will permit to avoid unjustified overestimating or understating of the waste category which prevents as unjustified expenditures on their treating so undertaking of the necessary measures providing radiation safety.

  1. Assessment of second- and third-order ionospheric effects on regional networks: case study in China with longer CMONOC GPS coordinate time series

    Science.gov (United States)

    Deng, Liansheng; Jiang, Weiping; Li, Zhao; Chen, Hua; Wang, Kaihua; Ma, Yifang

    2017-02-01

    Higher-order ionospheric (HOI) delays are one of the principal technique-specific error sources in precise global positioning system analysis and have been proposed to become a standard part of precise GPS data processing. In this research, we apply HOI delay corrections to the Crustal Movement Observation Network of China's (CMONOC) data processing (from January 2000 to December 2013) and furnish quantitative results for the effects of HOI on CMONOC coordinate time series. The results for both a regional reference frame and global reference frame are analyzed and compared to clarify the HOI effects on the CMONOC network. We find that HOI corrections can effectively reduce the semi-annual signals in the northern and vertical components. For sites with lower semi-annual amplitudes, the average decrease in magnitude can reach 30 and 10 % for the northern and vertical components, respectively. The noise amplitudes with HOI corrections and those without HOI corrections are not significantly different. Generally, the HOI effects on CMONOC networks in a global reference frame are less obvious than the results in the regional reference frame, probably because the HOI-induced errors are smaller in comparison to the higher noise levels seen when using a global reference frame. Furthermore, we investigate the combined contributions of environmental loading and HOI effects on the CMONOC stations. The largest loading effects on the vertical displacement are found in the mid- to high-latitude areas. The weighted root mean square differences between the corrected and original weekly GPS height time series of the loading model indicate that the mass loading adequately reduced the scatter on the CMONOC height time series, whereas the results in the global reference frame showed better agreements between the GPS coordinate time series and the environmental loading. When combining the effects of environmental loading and HOI corrections, the results with the HOI corrections reduced

  2. Assessment of second- and third-order ionospheric effects on regional networks: case study in China with longer CMONOC GPS coordinate time series

    Science.gov (United States)

    Deng, Liansheng; Jiang, Weiping; Li, Zhao; Chen, Hua; Wang, Kaihua; Ma, Yifang

    2016-09-01

    Higher-order ionospheric (HOI) delays are one of the principal technique-specific error sources in precise global positioning system analysis and have been proposed to become a standard part of precise GPS data processing. In this research, we apply HOI delay corrections to the Crustal Movement Observation Network of China's (CMONOC) data processing (from January 2000 to December 2013) and furnish quantitative results for the effects of HOI on CMONOC coordinate time series. The results for both a regional reference frame and global reference frame are analyzed and compared to clarify the HOI effects on the CMONOC network. We find that HOI corrections can effectively reduce the semi-annual signals in the northern and vertical components. For sites with lower semi-annual amplitudes, the average decrease in magnitude can reach 30 and 10 % for the northern and vertical components, respectively. The noise amplitudes with HOI corrections and those without HOI corrections are not significantly different. Generally, the HOI effects on CMONOC networks in a global reference frame are less obvious than the results in the regional reference frame, probably because the HOI-induced errors are smaller in comparison to the higher noise levels seen when using a global reference frame. Furthermore, we investigate the combined contributions of environmental loading and HOI effects on the CMONOC stations. The largest loading effects on the vertical displacement are found in the mid- to high-latitude areas. The weighted root mean square differences between the corrected and original weekly GPS height time series of the loading model indicate that the mass loading adequately reduced the scatter on the CMONOC height time series, whereas the results in the global reference frame showed better agreements between the GPS coordinate time series and the environmental loading. When combining the effects of environmental loading and HOI corrections, the results with the HOI corrections reduced

  3. A short biography of Hubert Ludwig and a note on the publication dates of his monograph Die Seewalzen (1889-1892).

    Science.gov (United States)

    Reich, Mike

    2015-12-03

    The dates of publication of Hubert Ludwig's (1852-1913) comprehensive monograph Die Seewalzen [= Sea cucumbers] are reviewed. The precise publication dates of his volume, originally published in 16 fascicles and 8 parts/issues, delivered between 1889 and 1892, has been re-examined. Additionally, a short biographical note on Hubert Ludwig's life and a discussion of all new taxa introduced by him in his monograph is given.

  4. Effect of electroless nickel on the series resistance of high-efficiency inkjet printed passivated emitter rear contacted solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Lenio, Martha A.T. [REC Technology US, Inc., 1159 Triton Dr., Foster City, CA 94301 (United States); Lennon, A.J.; Ho-Baillie, A.; Wenham, S.R. [ARC Photovoltaics Centre of Excellence, University of NSW, Sydney, NSW 2052 (Australia)

    2010-12-15

    Many existing and emerging solar cell technologies rely on plated metal to form the front surface contacts, and aluminium to form the rear contact. Interactions between the metal plating solutions and the aluminium rear can have a significant impact on cell performance. This paper describes non-uniform nickel deposition on the sintered aluminium rear surface of passivated emitter and rear contacted (PERC) cells patterned using an inkjet printing technique. Rather than being plated homogeneously over the entire rear surface as is observed on an alloyed aluminium rear, the nickel is plated only in the vicinity of the point openings in the rear surface silicon dioxide dielectric layer. Furthermore, this non-uniform nickel deposition was shown to increase the contact resistance of the rear point contacts by an order of magnitude, resulting in higher series resistance values for these fabricated PERC cells. (author)

  5. Summation of series

    CERN Document Server

    Jolley, LB W

    2004-01-01

    Over 1,100 common series, all grouped for easy reference. Arranged by category, these series include arithmetical and geometrical progressions, powers and products of natural numbers, figurate and polygonal numbers, inverse natural numbers, exponential and logarithmic series, binomials, simple inverse products, factorials, trigonometrical and hyperbolic expansions, and additional series. 1961 edition.

  6. Series editorial: Network and Service Management Series

    NARCIS (Netherlands)

    Pavlou, George; Pras, Aiko

    2010-01-01

    This is the ninth issue of the series on Network and Service Management, which is typically published twice a year. It was originally published in April and October, but since last year it is published in July and December. The series provides articles on the latest developments in this well establi

  7. Series editorial: Network and Service Management Series

    NARCIS (Netherlands)

    Pavlou, George; Pras, Aiko

    2011-01-01

    This is the 11th issue of the series on Network and Service Management, which is typically published twice a year. It was originally published in April and October but since last year it is published in July and December. The series provides articles on the latest developments in this well-establish

  8. The BEYOND center of excellence for the effective exploitation of satellite time series towards natural disasters monitoring and assessment

    Science.gov (United States)

    Kontoes, Charalampos; Papoutsis, Ioannis; Amiridis, Vassilis; Balasis, George; Keramitsoglou, Iphigenia; Herekakis, Themistocles; Christia, Eleni

    2014-05-01

    BEYOND project (2013-2016, 2.3Meuro) funded under the FP7-REGPOT scheme is an initiative which aims to build a Centre of Excellence for Earth Observation (EO) based monitoring of natural disasters in south-eastern Europe (http://beyond-eocenter.eu/), established at the National Observatory of Athens (NOA). The project focuses on capacity building on top of the existing infrastructure, aiming at unlocking the institute's potential through the systematic interaction with high-profile partners across Europe, and at consolidating state-of-the-art equipment and technological know-how that will allow sustainable cutting-edge interdisciplinary research to take place with an impact on the regional and European socioeconomic welfare. The vision is to set up innovative integrated observational solutions to allow a multitude of space borne and ground-based monitoring networks to operate in a complementary and cooperative manner, create archives and databases of long series of observations and higher level products, and make these available for exploitation with the involvement of stakeholders. In BEYOND critical infrastructural components are being procured for fostering access, use, retrieval and analysis of long EO data series and products. In this framework NOA has initiated activities for the development, installation and operation of important acquisition facilities and hardware modules, including space based observational infrastructures as the X-/L-band acquisition station for receiving EOS Aqua/Terra, NPP, JPSS, NOAA, Metop, Feng Yun data in real time, the setting up of an ESA's Mirror Site of Sentinel missions to be operable from 2014 onwards, an advanced Raman Lidar portable station, a spectrometer facility, several ground magnetometer stations. All these are expected to work in synergy with the existing capacity resources and observational networks including the MSG/SEVIRI acquisition station, nationwide seismographic, GPS, meteo and atmospheric networks. The

  9. [Effectiveness and safety of lenalidomide in myelofibrosis patients: a case series from the Spanish compassionate use program].

    Science.gov (United States)

    Castillo, I; Ojea, Ma A; Boqué, C; Asensio, A; Hermosilla, Ma M; Blanes, M

    2013-01-01

    Objetivo: La mielofibrosis (MF) es una neoplasia mieloproliferativa crónica (NMPc) caracterizada por la proliferación clonal de la célula germinal hematopoyética multipotente, fibrosis y angiogénesis de la médula ósea, y con hematopoyesis extramedular. Lenalidomida es un agente inmunomodulador y antiangiogénico, que ha mostrado beneficio clínico en pacientes con MF en diversos ensayos clínicos de fase II. En el presente trabajo presentamos los resultados de la evaluación retrospectiva de una serie de 32 pacientes diagnosticados de MF que recibieron tratamiento con lenalidomida dentro de un programa de uso compasivo en hospitales españoles. Método: Estudio multicéntrico, retrospectivo de una serie de casos de MF en tratamiento compasivo con lenalidomida. Resultados: Se recogió información de 32 pacientes con MF que habían sido tratados con lenalidomida en 17 hospitales españoles. La mediana de edad fue de 68 años (extremos, 50-83), el 72% eran varones. Veintiséis (81%) pacientes presentaban un riesgo intermedio-alto según la puntuación pronóstica de Dupriez. La dosis de lenalidomida programada fue en 16 pacientes de 10 mg/día durante 21 días en ciclos de 28 días; el resto de los pacientes recibió dosis inferiores u otros esquemas. Se dispuso de la evaluación de respuesta en 29 de los 32 pacientes. Dos pacientes presentaron respuesta clínico-hematológica completa y 14 presentaron respuesta parcial. Los acontecimientos adversos más frecuentemente observados fueron neutropenia (56%), trombocitopenia (50%), y anemia (40%). Conclusiones: El tratamiento continuado con lenalidomida es activo en pacientes con MF fuertemente pretratados. La mielosupresión que provoca la lenalidomida y otras toxicidades asociadas son manejables con ajustes de dosis.

  10. A time series study on the effects of heat on mortality and evaluation of heterogeneity into European and Eastern-Southern Mediterranean cities: results of EU CIRCE project

    OpenAIRE

    Dörbudak, Zeynep; Leone, Michela; D'Ippoliti, Daniela; De Sario, Manuela; Analitis, Antonis; Menne, Bettina; Katsouyanni, Klea; de'Donato, Francesca K.; Basagana, Xavier; Ben Salah, Afif; Casimiro, Elsa; Iniguez, Carmen; Peretz, Chava; Wolf, Tanja; Michelozzi, Paola

    2013-01-01

    RESEARCH Open Access A time series study on the effects of heat on mortality and evaluation of heterogeneity into European and Eastern-Southern Mediterranean cities: results of EU CIRCE project Michela Leone1*, Daniela D’Ippoliti1, Manuela De Sario1, Antonis Analitis2, Bettina Menne3, Klea Katsouyanni2, Francesca K de’ Donato1, Xavier Basagana4,5,6, Afif Ben Salah7, Elsa Casimiro8, Zeynep Dörtbudak9, Carmen Iñiguez4,10,11, Chava Peretz12, Tanja Wolf3 and Paola Michelozzi1...

  11. An investigation into the effects of cognitive behavioral therapy on patients with chronic depression: a small case series

    Directory of Open Access Journals (Sweden)

    Horn GL

    2012-10-01

    Full Text Available Gemma Louise HornUniversity of Dundee, Scotland, UKBackground: National Institute for Clinical Excellence (NICE guidelines recommend a combination of cognitive behavioral therapy (CBT and antidepressants to treat chronic depression. The Cognitive Behavioral Analysis System of Psychotherapy (CBASP is the only therapy model specifically designed for the treatment of chronic depression.Objectives: To determine the clinical response to the CBASP of patients in a specialist clinical service for affective disorder and to ascertain their views on the value of the CBASP for their condition.Methods: Qualitative data from interviews including a questionnaire and objective data from Becks Depression Inventory II symptom rating scales were used to monitor the progress of a small case series of five patients with chronic, treatment refractory depression as they received the CBASP over a 10-month period.Results: Common themes from patient interviews show very positive engagement and attitudes to the CBASP from the questionnaire. Rating scales from Becks Depression Inventory II pre- and posttreatment showed very little change for three patients with improvements between 2 and 7 points but deterioration in symptoms of 2 points for the fourth patient.Conclusion: The CBASP is a well-liked and positive therapy that helps patients manage their lives and deal with personal relationships, although objective data indicate little change in symptom severity.Keywords: cognitive behavioral therapy, chronic depression, CBASP

  12. Effects of fluoroquinolone restriction (from 2007 to 2012) on Clostridium difficile infections: interrupted time-series analysis.

    Science.gov (United States)

    Sarma, J B; Marshall, B; Cleeve, V; Tate, D; Oswald, T; Woolfrey, S

    2015-09-01

    Antimicrobial stewardship is a key component in the reduction of healthcare-associated infections, particularly Clostridium difficile infection (CDI). We successfully restricted the use of cephalosporins and, subsequently, fluoroquinolones. From an endemically high level of >280 cases per year in 2007-08, the number of CDIs reduced to 72 cases in 2011-12. To describe the implementation and impact of fluoroquinolone restriction on CDI. This was an interrupted time-series analysis pre and post fluoroquinolone restriction for 60 months based on a Poisson distribution model. In June 2008, fluoroquinolone consumption halved to about 5 defined daily doses (DDD) per 100 occupied bed-days (OBD). This was followed by a significant fall in CDI number [rate ratio (RR): 0.332; 95% confidence interval (CI): 0.240-0.460] which remained low over the subsequent months. Subsequently, fluoroquinolone consumption was further reduced to about 2 DDD/100 OBD in June 2010 accompanied by further reduction in CDI rate (RR: 0.394; 95% CI: 0.199-0.781). In a univariate Poisson model the CDI rate was associated with fluoroquinolone usage (RR: 1.086; 95% CI: 1.077-1.094). We conclude that in an environment where cephalosporin usage is already low, the reduction in fluoroquinolone usage was associated with an immediate, large, and significant reduction in CDI cases. Copyright © 2015 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

  13. Effect of nocturnal sound reduction on the incidence of delirium in intensive care unit patients: An interrupted time series analysis.

    Science.gov (United States)

    van de Pol, Ineke; van Iterson, Mat; Maaskant, Jolanda

    2017-08-01

    Delirium in critically-ill patients is a common multifactorial disorder that is associated with various negative outcomes. It is assumed that sleep disturbances can result in an increased risk of delirium. This study hypothesized that implementing a protocol that reduces overall nocturnal sound levels improves quality of sleep and reduces the incidence of delirium in Intensive Care Unit (ICU) patients. This interrupted time series study was performed in an adult mixed medical and surgical 24-bed ICU. A pre-intervention group of 211 patients was compared with a post-intervention group of 210 patients after implementation of a nocturnal sound-reduction protocol. Primary outcome measures were incidence of delirium, measured by the Intensive Care Delirium Screening Checklist (ICDSC) and quality of sleep, measured by the Richards-Campbell Sleep Questionnaire (RCSQ). Secondary outcome measures were use of sleep-inducing medication, delirium treatment medication, and patient-perceived nocturnal noise. A significant difference in slope in the percentage of delirium was observed between the pre- and post-intervention periods (-3.7% per time period, p=0.02). Quality of sleep was unaffected (0.3 per time period, p=0.85). The post-intervention group used significantly less sleep-inducing medication (pdelirium in ICU patients was significantly reduced after implementation of a nocturnal sound-reduction protocol. However, reported sleep quality did not improve. Copyright © 2017. Published by Elsevier Ltd.

  14. The effects of pay for performance on disparities in stroke, hypertension, and coronary heart disease management: interrupted time series study.

    Science.gov (United States)

    Lee, John Tayu; Netuveli, Gopalakrishnan; Majeed, Azeem; Millett, Christopher

    2011-01-01

    The Quality and Outcomes Framework (QOF), a major pay-for-performance programme, was introduced into United Kingdom primary care in April 2004. The impact of this programme on disparities in health care remains unclear. This study examines the following questions: has this pay for performance programme improved the quality of care for coronary heart disease, stroke and hypertension in white, black and south Asian patients? Has this programme reduced disparities in the quality of care between these ethnic groups? Did general practices with different baseline performance respond differently to this programme? Retrospective cohort study of patients registered with family practices in Wandsworth, London during 2007. Segmented regression analysis of interrupted time series was used to take into account the previous time trend. Primary outcome measures were mean systolic and diastolic blood pressure, and cholesterol levels. Our findings suggest that the implementation of QOF resulted in significant short term improvements in blood pressure control. The magnitude of benefit varied between ethnic groups with a statistically significant short term reduction in systolic BP in white and black but not in south Asian patients with hypertension. Disparities in risk factor control were attenuated only on few measures and largely remained intact at the end of the study period. Pay for performance programmes such as the QOF in the UK should set challenging but achievable targets. Specific targets aimed at reducing ethnic disparities in health care may also be needed.

  15. Toward an Educated Health Consumer: Mass Communication and Quality in Medical Care. Fogarty International Series on the Teaching of Preventive Medicine. Volume 7.

    Science.gov (United States)

    Marshall, Carter L.

    Focus in this preventive medicine monograph for health professionals is on consumer health education and the current and potential effects of mass communication on the quality of medical care. Following an introduction, the content is presented in four chapters. Chapter 1 covers the state of the art in consumer health education and discusses three…

  16. Effects of series and parallel resistances on the C-V characteristics of silicon-based metal oxide semiconductor (MOS) devices

    Science.gov (United States)

    Omar, Rejaiba; Mohamed, Ben Amar; Adel, Matoussi

    2015-04-01

    This paper investigates the electrical behavior of the Al/SiO2/Si MOS structure. We have used the complex admittance method to develop an analytical model of total capacitance applied to our proposed equivalent circuit. The charge density, surface potential, semiconductor capacitance, flatband and threshold voltages have been determined by resolving the Poisson transport equations. This modeling is used to predict in particular the effects of frequency, parallel and series resistance on the capacitance-voltage characteristic. Results show that the variation of both frequency and parallel resistance causes strong dispersion of the C-V curves in the inversion regime. It also reveals that the series resistance influences the shape of C-V curves essentially in accumulation and inversion modes. A significant decrease of the accumulation capacitance is observed when R s increases in the range 200-50000 Ω. The degradation of the C-V magnitude is found to be more pronounced when the series resistance depends on the substrate doping density. When R s varies in the range 100 Ω-50 kΩ, it shows a decrease in the flatband voltage from -1.40 to -1.26 V and an increase in the threshold voltage negatively from -0.28 to -0.74 V, respectively. Good agreement has been observed between simulated and measured C-V curves obtained at high frequency. This study is necessary to control the adverse effects that disrupt the operation of the MOS structure in different regimes and optimizes the efficiency of such electronic device before manufacturing.

  17. Effects of fluoroquinolone restriction (from 2007 to 2012) on resistance in Enterobacteriaceae: interrupted time-series analysis.

    Science.gov (United States)

    Sarma, J B; Marshall, B; Cleeve, V; Tate, D; Oswald, T; Woolfrey, S

    2015-09-01

    Antibiotic stewardship is a key component in the effort to reduce healthcare-associated infections. To describe the implementation and analyse the impact of fluoroquinolone restriction on resistance in Enterobacteriaceae, focusing on urinary isolates of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli, which were historically almost universally resistant to fluoroquinolones. ESBL-producing E. coli hospital and community isolates, obtained between April 2009 and March 2012 from consecutive non-duplicate urine samples, were included in an interrupted time-series analysis based on a Poisson distribution model. Periods before and after fluoroquinolone restriction were compared. The trend in fluoroquinolone resistance in all urinary isolates of Enterobacteriaceae (N ≈ 20,000 per year) and blood culture isolates of E. coli (N ≈ 350) between 2009 and 2013 were also analysed. A large decline in the percentage of ciprofloxacin-resistant ESBL-producing urinary E. coli isolates was observed in both hospital (risk ratio: 0.473; 95% confidence interval: 0.315-0.712) and community settings (0.098; 0.062-0.157). The decline was also marked in all urinary isolates of Enterobacteriaceae and E. coli isolates from blood cultures. We conclude that reducing fluoroquinolone usage to a level of ≤2 defined daily doses per 100 occupied bed-days in hospital sufficiently removed selection pressure to allow resistant Enterobacteriaceae – specifically, the UK endemic strains of ESBL-producing E. coli – to revert back to fluoroquinolone susceptibility within a short span of four months. This was accompanied with a concomitant reduction in overall ESBL burden. Copyright © 2015 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

  18. Effect of Training Class Label Noise on Classification Performances for Land Cover Mapping with Satellite Image Time Series

    Directory of Open Access Journals (Sweden)

    Charlotte Pelletier

    2017-02-01

    Full Text Available Supervised classification systems used for land cover mapping require accurate reference databases. These reference data come generally from different sources such as field measurements, thematic maps, or aerial photographs. Due to misregistration, update delay, or land cover complexity, they may contain class label noise, i.e., a wrong label assignment. This study aims at evaluating the impact of mislabeled training data on classification performances for land cover mapping. Particularly, it addresses the random and systematic label noise problem for the classification of high resolution satellite image time series. Experiments are carried out on synthetic and real datasets with two traditional classifiers: Support Vector Machines (SVM and Random Forests (RF. A synthetic dataset has been designed for this study, simulating vegetation profiles over one year. The real dataset is composed of Landsat-8 and SPOT-4 images acquired during one year in the south of France. The results show that both classifiers are little influenced for low random noise levels up to 25%–30%, but their performances drop down for higher noise levels. Different classification configurations are tested by increasing the number of classes, using different input feature vectors, and changing the number of training instances. Algorithm complexities are also analyzed. The RF classifier achieves high robustness to random and systematic label noise for all the tested configurations; whereas the SVM classifier is more sensitive to the kernel choice and to the input feature vectors. Finally, this work reveals that the cross-validation procedure is impacted by the presence of class label noise.

  19. Light and Plants. A Series of Experiments Demonstrating Light Effects on Seed Germination, Plant Growth, and Plant Development.

    Science.gov (United States)

    Downs, R. J.; And Others

    A brief summary of the effects of light on plant germination, growth and development, including photoperiodism and pigment formation, introduces 18 experiments and demonstrations which illustrate aspects of these effects. Detailed procedures for each exercise are given, the expected results outlined, and possible sources of difficulty discussed.…

  20. Biowaiver monographs for immediate-release solid oral dosage forms: Zidovudine (azidothymidine).

    Science.gov (United States)

    Soares, Kelen C C; Rediguieri, Camila F; Souza, Jacqueline; Serra, Cristina Helena R; Abrahamsson, Bertil; Groot, D W; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Dressman, Jennifer

    2013-08-01

    Literature data on the properties of zidovudine relevant to waiver of in vivo bioequivalence (BE) testing requirements for the approval of immediate-release (IR) solid oral dosage forms containing zidovudine alone or in combination with other active pharmaceutical ingredients (APIs) are reviewed. Solubility, dissolution, and permeability data for zidovudine, along with its dosing schedule, therapeutic index and pharmacokinetic properties, and reports related to BE/bioavailability were all taken into consideration. Data for solubility and permeability suggest that zidovudine belongs to Class I according to the Biopharmaceutics Classification System. Also, zidovudine is not a narrow therapeutic index drug. Although five out of 13 formulations tested in vivo (mostly of unreported composition) failed to show BE, it appears that in vitro studies performed according to biowaiver methods could predict in vivo behavior. Nevertheless, it is highly recommended that if a biowaiver is to be applied, excipient choices be limited to those found in IR drug products approved in International Conference on Harmonisation (ICH) or associated countries in the same dosage form (Table 2 of this monograph), in their usual amounts. These conclusions apply to products containing zidovudine as the only API and also to fixed combination products containing zidovudine with respect to the zidovudine component of the formulation.

  1. Biowaiver monographs for immediate-release solid oral dosage forms: codeine phosphate.

    Science.gov (United States)

    Dahan, Arik; Wolk, Omri; Zur, Moran; Amidon, Gordon L; Abrahamsson, Bertil; Cristofoletti, Rodrigo; Groot, D W; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Dressman, Jennifer B

    2014-06-01

    The present monograph reviews data relevant to applying the biowaiver procedure for the approval of immediate-release multisource solid dosage forms containing codeine phosphate. Both biopharmaceutical and clinical data of codeine were assessed. Solubility studies revealed that codeine meets the "highly soluble" criteria according to World Health Organization (WHO), the European Medicines Agency (EMA), and the United States Food and Drug Administration (US FDA). Codeine's fraction of dose absorbed in humans was reported to be high (>90%) based on cumulative urinary excretion of drug and drug-related material following oral administration. The permeability of codeine was also assessed to be high in both Caco-2 monolayers and rat intestinal perfusion studies. The main risks associated with codeine, that is, toxicity (attributed to CYP2D6 polymorphism) and its abuse potential, are present irrespective of the dosage form, and do not need to be taken into account for bioequivalence (BE) considerations. Taken together, codeine is a class 1 drug with manageable risk and is a good candidate for waiver of in vivo BE studies.

  2. Metrics and Science Monograph Collections at the Marston Science Library, University of Florida

    Directory of Open Access Journals (Sweden)

    Stephanie C. Haas

    2010-01-01

    Full Text Available As academic libraries are increasingly supported by a matrix of database functions, the use of data mining and visualization techniques offer significant potential for future collection development and service initiatives based on quantifiable data. While data collection techniques are still not standardized and results may be skewed because of granularity problems, faulty algorithms, and a host of other factors, useful baseline data is extractable and broad trends can be identified.The purpose of the current study is to provide an initial assessment of data associated with science monograph collection at the Marston Science Library (MSL, University of Florida. These sciences fall within the major Library of Congress Classification schedules of Q, S, and T, excluding TR, TT, and TX. The Rs are also excluded as these subjects are the responsibility of the Health Science Center Library which is connected with the medical school and the teaching hospital. The overall strategy of this project is to look at the potential science audiences within the university community and analyze data related to purchasing and circulation patterns, e-book usage, and interlibrary loan (ILL statistics. This paper presents the results from the academic year July 1, 2008 to June 30, 2009, because all data reservoirs needed were available for the circulation and ILL data. The Springer e-book study is based on 2009 data. The research team consisted of both librarians and technical support staff from MSL, the Acquisitions Department, the Cataloging Department, and the IT Department.

  3. Tools to Ensure Safe Medicines: New Monograph Tests in USP-NF

    Directory of Open Access Journals (Sweden)

    Catherine Sheehan

    2010-09-01

    Full Text Available This paper describes USP-NF compendial updates to six ‘high-priority” excipient monographs: Glycerin, Propylene Glycol, Sorbitol Solution, Sorbitol Sorbitan Solution, Noncrystallizing Sorbitol Solution and Maltitol Solution. The USP-NF revisions arose from the Food and DrugAdministration’s (FDA’s requests to include, as part of each monograph’s Identification test, a limit test to detect the presence of Diethylene Glycol (DEG, a toxic adulterant. These revisions alignwith the 2007 FDA Guidance for Industry: Testing of Glycerin for Diethylene Glycol (1, that drug product manufacturers perform a specific identity test for DEG on all containers of all lots ofglycerin before glycerin is used in the manufacture and preparation of drug products. This paper describes several risk factors due to a complex global excipient supply chain, nonspecific specifications, inadequate supply chain qualification, and poor understanding of regulations. Strengthening and conformance to compendial specifications is one of the tools necessary to mitigate risk and help prevent the next DEG adulteration that is part of USP’s efforts to ensure safe medicines.

  4. Clinical roundtable monograph. New alternatives in CLL therapy: managing adverse events.

    Science.gov (United States)

    Chanan-Khan, Asher; Kipps, Thomas; Stilgenbauer, Stephan

    2010-08-01

    Chronic lymphocytic leukemia (CLL) is a B-cell leukemia mainly affecting older adults. Historically, CLL has been regarded as an incurable disease, and treatment has been confined to cytotoxic chemotherapy regimens. However, prognosis for patients treated with these agents remained poor, prompting the development of new, targeted agents. The introduction of rituximab, a CD20-targeted monoclonal antibody, revolutionized the treatment for this disease. Rituximab in combination with fludarabine improved response rates and length of progression-free survival. The success of rituximab in this setting has prompted the development of many more investigational agents for CLL, including other antibody agents. However, as with any medication, the potential benefit achieved with CLL therapies is mitigated by the safety risk for the patient. These agents have been associated with adverse events such as immunosuppression, reactivation of cytomegalovirus, and infusion-related reactions that can occur with antibody administration. Adverse events can greatly affect the patient’s quality of life and ability to tolerate therapy. Management of adverse events is a critical component of the overall treatment strategy for CLL, particularly in elderly patients. In this clinical roundtable monograph, 3 expert physicians discuss the latest clinical studies evaluating the treatment of CLL, focusing on the adverse events associated with each agent and the potential interventions that can be used to manage their occurrence.

  5. Clinical roundtable monograph: new and emerging treatments for advanced prostate cancer.

    Science.gov (United States)

    George, Daniel J; Kantoff, Philip W; Lin, Daniel W

    2011-06-01

    Historically, the treatment of metastatic castration-resistant prostate cancer (CRPC) has been limited to chemotherapeutic regimens that did not improve patient survival. In 2004, clinical studies began to demonstrate significant improvements in patient outcomes, including overall survival, with docetaxel versus mitoxantrone chemotherapy. Since these pivotal trials, the combination of docetaxel plus prednisone has become a standard of care for patients with metastatic CRPC. However, the limited survival benefit achieved with this regimen prompted several investigations into the development of alternative therapeutic options. Recent advances have now led to an unprecedented number of new drug approvals within the past year, providing many new treatment options for patients with metastatic CRPC. Sipuleucel-T, considered a new paradigm in cancer treatment, is the first such immunotherapeutic agent approved by the US Food and Drug Administration. Other successes include abiraterone acetate, the first androgen biosynthesis inhibitor, and cabazitaxel, a novel microtubule inhibitor, both of which have demonstrated improved survival following docetaxel failure. The bone-targeting agent denosumab, also recently approved in this setting, offers these patients significant improvement in the prevention of skeletal-related events. The data supporting the approval of each of these agents are described in this monograph, as are current approaches in the treatment of metastatic CRPC and ongoing clinical trials of novel treatments and strategies. The experts also discuss several of the issues regarding the introduction of these novel agents into clinical practice for metastatic CRPC patients.

  6. Biowaiver monograph for immediate-release solid oral dosage forms: acetylsalicylic acid.

    Science.gov (United States)

    Dressman, Jennifer B; Nair, Anita; Abrahamsson, Bertil; Barends, Dirk M; Groot, D W; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Zimmer, Markus

    2012-08-01

    A biowaiver monograph for acetylsalicylic acid (ASA) is presented. Literature and experimental data indicate that ASA is a highly soluble and highly permeable drug, leading to assignment of this active pharmaceutical ingredient (API) to Class I of the Biopharmaceutics Classification System (BCS). Limited bioequivalence (BE) studies reported in the literature indicate that products that have been tested are bioequivalent. Most of the excipients used in products with a marketing authorization in Europe are not considered to have an impact on gastrointestinal motility or permeability. Furthermore, ASA has a wide therapeutic index. Thus, the risks to the patient that might occur if a nonbioequivalent product were to be incorrectly deemed bioequivalent according to the biowaiver procedure appear to be minimal. As a result, the BCS-based biowaiver procedure can be recommended for approval of new formulations of solid oral dosage forms containing ASA as the only API, including both multisource and reformulated products, under the following conditions: (1) excipients are chosen from those used in ASA products already registered in International Conference on Harmonization and associated countries and (2) the dissolution profiles of the test and the comparator products comply with the BE guidance. Copyright © 2012 Wiley Periodicals, Inc.

  7. Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Amoxicillin Trihydrate.

    Science.gov (United States)

    Thambavita, Dhanusha; Galappatthy, Priyadarshani; Mannapperuma, Uthpali; Jayakody, Lal; Cristofoletti, Rodrigo; Abrahamsson, Bertil; Groot, Dirk W; Langguth, Peter; Mehta, Mehul; Parr, Alan; Polli, James E; Shah, Vinod P; Dressman, Jennifer

    2017-10-01

    Literature and experimental data relevant to waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release solid oral dosage forms containing amoxicillin trihydrate are reviewed. Solubility and permeability characteristics according to the Biopharmaceutics Classification System (BCS), therapeutic uses, therapeutic index, excipient interactions, as well as dissolution and BE and bioavailability studies were taken into consideration. Solubility and permeability studies indicate that amoxicillin doses up to 875 mg belong to BCS class I, whereas 1000 mg belongs to BCS class II and doses of more than 1000 mg belong to BCS class IV. Considering all aspects, the biowaiver procedure can be recommended for solid oral products of amoxicillin trihydrate immediate-release preparations containing amoxicillin as the single active pharmaceutical ingredient at dose strengths of 875 mg or less, provided (a) only the excipients listed in this monograph are used, and only in their usual amounts, (b) the biowaiver study is performed according to the World Health Organization-, U.S. Food and Drug Administration-, or European Medicines Agency-recommended method using the innovator as the comparator, and (c) results comply with criteria for "very rapidly dissolving" or "similarly rapidly dissolving." Products containing other excipients and those containing more than 875 mg amoxicillin per unit should be subjected to an in vivo BE study. Copyright © 2017 American Pharmacists Association®. All rights reserved.

  8. Tools to Ensure Safe Medicines: New Monograph Tests in USP-NF

    Directory of Open Access Journals (Sweden)

    Catherine Sheehan

    2010-06-01

    Full Text Available This paper describes USP-NF compendial updates to six ‘high-priority” excipient monographs: Glycerin, Propylene Glycol, Sorbitol Solution, Sorbitol Sorbitan Solution, Noncrystallizing Sorbitol Solution and Maltitol Solution. The USP-NF revisions arose from the Food and Drug Administration’s (FDA’s requests to include, as part of each monograph’s Identification test, a limit test to detect the presence of Diethylene Glycol (DEG, a toxic adulterant. These revisions align with the 2007 FDA Guidance for Industry: Testing of Glycerin for Diethylene Glycol (1, that drug product manufacturers perform a specific identity test for DEG on all containers of all lots of glycerin before glycerin is used in the manufacture and preparation of drug products. This paper describes several risk factors due to a complex global excipient supply chain, nonspecific specifications, inadequate supply chain qualification, and poor understanding of regulations. Strengthening and conformance to compendial specifications is one of the tools necessary to mitigate risk and help prevent the next DEG adulteration that is part of USP’s efforts to ensure safe medicines.

  9. Time series analysis.

    NARCIS (Netherlands)

    2013-01-01

    Time series analysis can be used to quantitatively monitor, describe, explain, and predict road safety developments. Time series analysis techniques offer the possibility of quantitatively modelling road safety developments in such a way that the dependencies between the observations of time series

  10. A synopsis on different homologous series of fomocaine derivatives. In vitro interactions with the cytochrome P450 system, toxicity, and local anaesthetic effects in rats--Part 1.

    Science.gov (United States)

    Lupp, Amelie; Karge, Elke; Dahse, Thomas; Glassl, Peter; Jung, Beate; Listing, Monika; Seeling, Andreas; Wange, Johannes; Wennek-Klose, Janett; Oelschläger, Herbert; Fleck, Christian

    2007-01-01

    Fomocaine (CAS 56583-43-6) is a basic ether-type local anaesthetic used in dermatological practice for surface anaesthesia. For many years, modifications of the fomocaine molecule have been pursued, e.g. to improve its physicochemical properties and also in view of possible new (systemic) applications, e.g. in the treatment of migraine or as antiarrhythmic. The present paper provides a survey of the investigations undertaken with all the different series of fomocaine derivatives synthesized so far with respect to their in vitro interaction capacity at the cytochrome P450 system, in vivo toxicity (LD50; paresis of the N. ischiadicus) and local anaesthetic effects (conduction anaesthesia at the N. ischiadicus; surface anaesthesia of the cornea) in rats. The main objective of this systematic comparison of the effects of all these substances was to assess possible basic structure-activity relationships.

  11. Functioning and effectiveness of electronic control devices such as the TASER® M- and X-series: a review of the current literature.

    Science.gov (United States)

    Kunz, Sebastian N; Zinka, Bettina; Fieseler, Sybille; Graw, Matthias; Peschel, Oliver

    2012-11-01

    Conducted electrical weapons (CEWs) such as the TASER(®) M- and X-series deliver short high-voltage, low-current energy pulses to temporarily paralyze a person by causing electrical interruption of the body's normal energy pulses. Despite many scientific publications, which classify the health risks of an appropriate use of the TASER device as minor, there still is a continuous uncertainty about possible side effects with human application. Based on a literature search of the National Library of Medicine's MEDLINE database's PubMed system of current publications, the following article describes the mechanisms by which the device operates and discusses possible pathophysiological consequences. The majority of current human literature has not found evidence of clinical relevant pathophysiological effects during and after an exposure of professionally applied CEWs. However, to be able to exclude possible health risks, a medical checkup of people who have been exposed to CEWs is essential.

  12. Effects of meteorological factors on daily hospital admissions for asthma in adults: a time-series analysis.

    Directory of Open Access Journals (Sweden)

    Yue Zhang

    Full Text Available There is limited evidence for the impacts of meteorological changes on asthma hospital admissions in adults in Shanghai, China.To quantitatively evaluate the short-term effects of daily mean temperature on asthma hospital admissions.Daily hospital admissions for asthma and daily mean temperatures between January 2005 and December 2012 were analyzed. After controlling for secular and seasonal trends, weather, air pollution and other confounding factors, a Poisson generalized additive model (GAM combined with a distributed lag non-linear model were used to explore the associations between temperature and hospital admissions for asthma.During the study periods, there were 15,678 hospital admissions for asthma by residents of Shanghai, an average 5.6 per day. Pearson correlation analysis found a significant negative correlation (r = -0.174, P<0.001 between asthma hospitalizations and daily mean temperature (DMT. The DMT effect on asthma increased below the median DMT, with lower temperatures associated with a higher risk of hospital admission for asthma. Generally, the cold effect appeared to be relatively acute, with duration lasting several weeks, while the hot effect was short-term. The relative risk of asthma hospital admissions associated with cold temperature (the 25th percentile of temperature relative to the median temperature was 1.20 (95% confidence interval [CI], 1.01∼1.41 at lag0-14. However, warmer temperatures were not associated with asthma hospital admissions.Cold temperatures may trigger asthmatic attacks. Effective strategies are needed to protect populations at risk from the effects of cold.

  13. Global Warming and the Greenhouse Effect: January 1986-January 1992. Quick Bibliography Series: QB 92-36.

    Science.gov (United States)

    MacLean, Jayne T.

    This bibliography contains 442 journal article, book, and audiovisual citations on global warming and the greenhouse effect entered into the National Agricultural Library's AGRICOLA database between January 1979 and March 1992. The bibliography contains an author and subject index as well as information on obtaining documents. (LZ)

  14. Creating and Sustaining Professional Learning Communities: Q&A with Stephanie Hirsh, Ph.D. 2016 Educator Effectiveness Webinar Series

    Science.gov (United States)

    Regional Educational Laboratory Mid-Atlantic, 2016

    2016-01-01

    In this webinar, Dr. Stephanie Hirsh, Executive Director of Learning Forward, presented the research on effective PLCs and shared her experiences in creating, assessing, and leading PLCs. This Q&A addressed questions participants had for Dr. Hirsh following the webinar. The webinar recording and PowerPoint presentation are also available.

  15. Induction and Mentoring of New Teachers: Q&A with Ellen Moir. REL Mid-Atlantic Teacher Effectiveness Webinar Series

    Science.gov (United States)

    Regional Educational Laboratory Mid-Atlantic, 2013

    2013-01-01

    In this webinar, Ellen Moir, CEO and founder of the New Teacher Center, shared research that shows evidence of the effectiveness of the NTC induction model in raising student achievement and its potential for reducing teacher attrition (Moir, 2009). This Q&A addressed the questions participants had for Ellen Moir following the webinar. The…

  16. Effect of Climate Factors on the Childhood Pneumonia in Papua New Guinea: A Time-Series Analysis.

    Science.gov (United States)

    Kim, Jinseob; Kim, Jong-Hun; Cheong, Hae-Kwan; Kim, Ho; Honda, Yasushi; Ha, Mina; Hashizume, Masahiro; Kolam, Joel; Inape, Kasis

    2016-02-15

    This study aimed to assess the association between climate factors and the incidence of childhood pneumonia in Papua New Guinea quantitatively and to evaluate the variability of the effect size according to their geographic properties. The pneumonia incidence in children under five-year and meteorological factors were obtained from six areas, including monthly rainfall and the monthly average daily maximum temperatures during the period from 1997 to 2006 from national health surveillance data. A generalized linear model was applied to measure the effect size of local and regional climate factor. The pooled risk of pneumonia in children per every 10 mm increase of rainfall was 0.24% (95% confidence interval: -0.01%-0.50%), and risk per every 1 °C increase of the monthly mean of the maximum daily temperatures was 4.88% (95% CI: 1.57-8.30). Southern oscillation index and dipole mode index showed an overall negative effect on childhood pneumonia incidence, -0.57% and -4.30%, respectively, and the risk of pneumonia was higher in the dry season than in the rainy season (pooled effect: 12.08%). There was a variability in the relationship between climate factors and pneumonia which is assumed to reflect distribution of the determinants of and vulnerability to pneumonia in the community.

  17. The Effects of a Changing Financial Context on the University of California. Research & Occasional Paper Series: CSHE.16.05

    Science.gov (United States)

    Kissler, Gerald R.; Switkes, Ellen

    2005-01-01

    California's loss of capital gains and stock options revenue during the recent economic downturn was one of the worst in the nation, and the resulting fiscal crisis led to reductions in State appropriations to the University of 15% over the past four years, while enrollments grew by 19%. This article examines the effects of this reduction in State…

  18. Effect of Climate Factors on the Childhood Pneumonia in Papua New Guinea: A Time-Series Analysis

    Directory of Open Access Journals (Sweden)

    Jinseob Kim

    2016-02-01

    Full Text Available This study aimed to assess the association between climate factors and the incidence of childhood pneumonia in Papua New Guinea quantitatively and to evaluate the variability of the effect size according to their geographic properties. The pneumonia incidence in children under five-year and meteorological factors were obtained from six areas, including monthly rainfall and the monthly average daily maximum temperatures during the period from 1997 to 2006 from national health surveillance data. A generalized linear model was applied to measure the effect size of local and regional climate factor. The pooled risk of pneumonia in children per every 10 mm increase of rainfall was 0.24% (95% confidence interval: −0.01%–0.50%, and risk per every 1 °C increase of the monthly mean of the maximum daily temperatures was 4.88% (95% CI: 1.57–8.30. Southern oscillation index and dipole mode index showed an overall negative effect on childhood pneumonia incidence, −0.57% and −4.30%, respectively, and the risk of pneumonia was higher in the dry season than in the rainy season (pooled effect: 12.08%. There was a variability in the relationship between climate factors and pneumonia which is assumed to reflect distribution of the determinants of and vulnerability to pneumonia in the community.

  19. Effects of Near Soil Surface Characteristics on the Soil Detachment Process in a Chronological Series of Vegetation Restoration

    Science.gov (United States)

    Wang, Bing

    2017-04-01

    The effects of near soil surface characteristics on the soil detachment process might be different at different stages of vegetation restoration. This study was performed to investigate the effects of the near soil surface factors of plant litter, biological soil crusts (BSCs), dead roots and live roots on the soil detachment process by overland flow at different stages of restoration. Soil samples (1 m long, 0.1 m wide, and 0.05 m high) under four treatment conditions were collected from 1-yr-old and 24-yr-old natural grasslands and subjected to flow scouring under five different shear stresses ranging from 5.3 to 14.6 Pa. The results indicated that the effects of near soil surface characteristics on soil detachment were substantial during the process of vegetation restoration. The total reduction in the soil detachment capacity of the 1-yr-old grassland was 98.1%, and of this total, 7.9%, 30.0% and 60.2% was attributed to the litter, BSCs and plant roots, respectively. In the 24-yr-old grassland, the soil detachment capacity decreased by 99.0%, of which 13.2%, 23.5% and 62.3% was caused by the litter, BSCs and plant roots, respectively. Combined with the previously published data of a 7-yr-old grassland, the influence of plant litter on soil detachment was demonstrated to increase with restoration time, but soil detachment was also affected by the litter type and composition. The role of BSCs was greater than that of plant litter in reducing soil detachment during the early stages of vegetation recovery. However, its contribution weakened with time since restoration. The influence of plant roots accounted for at least half or up to two-thirds of the total near soil surface factors, of which more than 72.6% was attributed to the physical binding effects of the roots. The chemical bonding effect of the roots increased with time since restoration and was greater than the effect of the litter on soil detachment in the late stages of vegetation restoration. The

  20. Estimating Urban Heat Island Effects on the Temperature Series of Uccle (Brussels, Belgium Using Remote Sensing Data and a Land Surface Scheme

    Directory of Open Access Journals (Sweden)

    Rafiq Hamdi

    2010-12-01

    Full Text Available In this letter, the urban heat island effects on the temperature time series of Uccle (Brussels, Belgium during the summers months 1960–1999 was estimated using both ground-based weather stations and remote sensing imagery, combined with a numerical land surface scheme including state-of-the-art urban parameterization, the Town Energy Balance Scheme. Analysis of urban warming based on remote sensing method reveals that the urban bias on minimum temperature is rising at a higher rate, 2.5 times (2.85 ground-based observed more, than on maximum temperature, with a linear trend of 0.15 °C (0.19 °C ground-based observed and 0.06 °C (0.06 °C ground-based observed per decade respectively. The results based on remote sensing imagery are compatible with estimates of urban warming based on weather stations. Therefore, the technique presented in this work is a useful tool in estimating the urban heat island contamination in long time series, countering the drawbacks of a ground-observational approach.

  1. Ten-year performance of Influenzanet: ILI time series, risks, vaccine effects, and care-seeking behaviour

    Directory of Open Access Journals (Sweden)

    Sander P. van Noort

    2015-12-01

    Full Text Available Recent public health threats have propelled major innovations on infectious disease monitoring, culminating in the development of innovative syndromic surveillance methods. Influenzanet is an internet-based system that monitors influenza-like illness (ILI in cohorts of self-reporting volunteers in European countries since 2003. We investigate and confirm coherence through the first ten years in comparison with ILI data from the European Influenza Surveillance Network and demonstrate country-specific behaviour of participants with ILI regarding medical care seeking. Using regression analysis, we determine that chronic diseases, being a child, living with children, being female, smoking and pets at home, are all independent predictors of ILI risk, whereas practicing sports and walking or bicycling for locomotion are associated with a small risk reduction. No effect for using public transportation or living alone was found. Furthermore, we determine the vaccine effectiveness for ILI for each season.

  2. Effect of Climate Factors on the Childhood Pneumonia in Papua New Guinea: A Time-Series Analysis

    OpenAIRE

    Jinseob Kim; Jong-Hun Kim; Hae-Kwan Cheong; Ho Kim; Yasushi Honda; Mina Ha; Masahiro Hashizume; Joel Kolam; Kasis Inape

    2016-01-01

    This study aimed to assess the association between climate factors and the incidence of childhood pneumonia in Papua New Guinea quantitatively and to evaluate the variability of the effect size according to their geographic properties. The pneumonia incidence in children under five-year and meteorological factors were obtained from six areas, including monthly rainfall and the monthly average daily maximum temperatures during the period from 1997 to 2006 from national health surveillance data...

  3. Detecting Climate Effects on Vegetation in Northern Mixed Prairie Using NOAA AVHRR 1-km Time-Series NDVI Data

    Directory of Open Access Journals (Sweden)

    Zhaoqin Li

    2012-01-01

    Full Text Available Grasslands hold varied grazing capacity, provide multiple habitats for diverse wildlife, and are a key component of carbon stock. Research has indicated that grasslands are experiencing effects related to recent climate trends. Understanding how grasslands respond to climate variation thus is essential. However, it is difficult to separate the effects of climate variation from grazing. This study aims to document vegetation condition under climate variation in Grasslands National Park (GNP of Canada, a grassland ecosystem without grazing for over 20 years, using Normalized Difference Vegetation Index (NDVI data to establish vegetation baselines. The main findings are (1 precipitation has more effects than temperature on vegetation; (2 the growing season of vegetation had an expanding trend indicated by earlier green-up and later senescence; (3 phenologically-tuned annual NDVI had an increasing trend from 1985 to 2007; and (4 the baselines of annual NDVI range from 0.13 to 0.32, and only the NDVI in 1999 is beyond the upper bound of the baseline. Our results indicate that vegetation phenology and condition have slightly changed in GNP since 1985, although vegetation condition in most years was still within the baselines.

  4. Magnetocaloric effect of Gd4(BixSb1-x)3 alloy series

    Energy Technology Data Exchange (ETDEWEB)

    Niu, Xuejun [Iowa State Univ., Ames, IA (United States)

    1999-01-01

    Alloys from the Gd4(BixSb1-x)3 series were prepared by melting a stoichiometric amounts of pure metals in an induction furnace. The crystal structure is of the anti-Th3P4 type (space group I$\\bar{4}$3d) for all the compounds tested. The linear increase of the lattice parameters with Bi concentration is attributed to the larger atomic radius of Bi than that of Sb. Magnetic measurements show that the alloys order ferromagnetically from 266K to 330K, with the ordering temperature increasing with decreasing Bi concentration. The alloys are soft ferromagnets below their Curie temperatures, and follow the Curie-Weiss law above their ordering temperatures. The paramagnetic effective magnetic moments are low compared to the theoretical value for a free Gd3+, while the ordered magnetic moments are close to the theoretical value for Gd. The alloys exhibit a moderate magnetocaloric effect (MCE) whose maxima are located between 270K and 338K and have relatively wide peaks. The peak MCE temperature decreases with decreasing Bi concentration while the peak height increases with decreasing Bi concentration. The Curie temperatures determined from inflection points of heat capacity are in good agreement with those obtained from the magnetocaloric effect. The MCE results obtained from the two different methods (magnetization and heat capacity) agree quite well with each other for all of the alloys in the series.

  5. Effectiveness of Non-Pharmacological Interventions to Prevent Falls in Older People: A Systematic Overview. The SENATOR Project ONTOP Series

    Science.gov (United States)

    Rimland, Joseph M.; Abraha, Iosief; Dell’Aquila, Giuseppina; Cruz-Jentoft, Alfonso; Soiza, Roy; Gudmusson, Adalsteinn; Petrovic, Mirko; O’Mahony, Denis; Todd, Chris; Cherubini, Antonio

    2016-01-01

    Background Falls are common events in older people, which cause considerable morbidity and mortality. Non-pharmacological interventions are an important approach to prevent falls. There are a large number of systematic reviews of non-pharmacological interventions, whose evidence needs to be synthesized in order to facilitate evidence-based clinical decision making. Objectives To systematically examine reviews and meta-analyses that evaluated non-pharmacological interventions to prevent falls in older adults in the community, care facilities and hospitals. Methods We searched the electronic databases Pubmed, the Cochrane Database of Systematic Reviews, EMBASE, CINAHL, PsycINFO, PEDRO and TRIP from January 2009 to March 2015, for systematic reviews that included at least one comparative study, evaluating any non-pharmacological intervention, to prevent falls amongst older adults. The quality of the reviews was assessed using AMSTAR and ProFaNE taxonomy was used to organize the interventions. Results Fifty-nine systematic reviews were identified which consisted of single, multiple and multifactorial non-pharmacological interventions to prevent falls in older people. The most frequent ProFaNE defined interventions were exercises either alone or combined with other interventions, followed by environment/assistive technology interventions comprising environmental modifications, assistive and protective aids, staff education and vision assessment/correction. Knowledge was the third principle class of interventions as patient education. Exercise and multifactorial interventions were the most effective treatments to reduce falls in older adults, although not all types of exercise were equally effective in all subjects and in all settings. Effective exercise programs combined balance and strength training. Reviews with a higher AMSTAR score were more likely to contain more primary studies, to be updated and to perform meta-analysis. Conclusions The aim of this overview of

  6. Go-and-Back method: Effective estimation of the hidden motion of proteins from single-molecule time series

    CERN Document Server

    Miyazaki, Makito

    2010-01-01

    We present an effective method for estimating the motion of proteins from the motion of attached probe particles in single-molecule experiments. The framework naturally incorporates Langevin dynamics to compute the most probable trajectory of the protein. By using a perturbation expansion technique, we achieve computational costs more than four orders of magnitude smaller than the conventional gradient descent method without loss of simplicity in the computation algorithm. We present illustrative applications of the method using simple models of single-molecule experiments and confirm that the proposed method yields reasonable estimates of the hidden motion in a highly efficient manner.

  7. Effect of Acupuncture on Pain and Quality of Life in Patients with Lumbar Spinal Stenosis: A Case Series Study.

    Science.gov (United States)

    Hadianfard, Mohammad J; Aminlari, Ali; Daneshian, Arghavan; Safarpour, Ali R

    2016-08-01

    Lumbar spinal stenosis (LSS) is a major cause of debilitation in adults, and acupuncture is a recommended treatment. We assessed the effect of acupuncture on pain and quality of life in patients with LSS. Twenty-four patients with LSS who had symptoms of neurogenic claudication were randomly selected and underwent 10 sessions of acupuncture. Pain and quality of life were evaluated before and immediately after the intervention and 6 weeks later using a visual analogue scale and Short Form-36 Health Survey. Paired t tests and repeated measure tests were used to analyze the data. The mean age of the patients was 48.2 ± 10.8 years. The mean visual analogue scale scores before and immediately after intervention (7.9 ± 1.3 and 4.3 ± 2.1) were statistically different (p acupuncture (p pain, and physical well-being. Therefore, acupuncture had a significant short-term effect on pain and quality of life in patients with LSS.

  8. The Effect of Neurofeedback Therapy on Reducing Symptoms Associated with Attention Deficit Hyperactivity Disorder: A Case Series Study

    Science.gov (United States)

    Deilami, Mostafa; Jahandideh, Asghar; Kazemnejad, Yousef; Fakour, Yousef; Alipoor, Shiva; Rabiee, Fatemeh; Pournesaie, Ghazal Saadat; Heidari, Rosemarie Noot; Mosavi, Seyed Aliasghar

    2016-01-01

    Introduction: This study aimed to evaluate the effectiveness of neurofeedback on attention deficit hyperactivity disorder. Methods: This is a quasi-experimental study without a control group. The study population included all children aged 5 to 12 years old affected with attention deficit hyperactivity disorders in Tehran, Iran who were referred to psychiatric clinics and given the diagnosis. The sample included 12 children with attention deficit hyperactivity disorder who were selected based on their availability (non-random sampling). They received 30 sessions of neurofeedback treatment, 2 times per week. Before and after neurofeedback training, the children were evaluated and compared with the use of cognitive assessment system test. Data were analyzed using dependent T-test. Results: The total mean score for pretest was 88.81 while the total mean score for the post test was 82.23. The mean in pretest for attention hyperactivity disorder was higher than the mean in the post test. Moreover, The difference of pretest and post test scores of children affected with learning disorder associated with ADHD was calculated that showed significant (P=0.003). Conclusion: Neurofeedback is effective in the improvement of attention deficit hyperactivity disorder. PMID:27303612

  9. Part 1. Short-term effects of air pollution on mortality: results from a time-series analysis in Chennai, India.

    Science.gov (United States)

    Balakrishnan, Kalpana; Ganguli, Bhaswati; Ghosh, Santu; Sankar, S; Thanasekaraan, Vijaylakshmi; Rayudu, V N; Caussy, Harry

    2011-03-01

    This report describes the results of a time-series analysis of the effect of short-term exposure to particulate matter with an aerodynamic diameter Chennai, India (formerly Madras). This was one of three sites in India chosen by HEI as part of its Public Health and Air Pollution in Asia (PAPA) initiative. The study involved integration and analysis of retrospective data for the years 2002 through 2004. The data were obtained from relevant government agencies in charge of routine data collection. Data on meteorologic confounders (including temperature, relative humidity, and dew point) were available on all days of the study period. Data on mortality were also available on all days, but information on cause-of-death (including accidental deaths) could not be reliably ascertained. Hence, only all-cause daily mortality was used as the major outcome for the time-series analyses. Data on PM10, nitrogen dioxide (NO2), and sulfur dioxide (SO2) were limited to a much smaller number of days, but spanned the full study period. Data limitations resulting from low sensitivity of gaseous pollutant measurements led to using only PM10 in the main analysis. Of the eight operational ambient air quality monitor (AQM) stations in the city, seven met the selection criteria set forth in the common protocol developed for the three PAPA studies in India. In addition, all raw data used in the analysis were subjected to additional quality assurance (QA) and quality control (QC) criteria to ensure the validity of the measurements. Two salient features of the PM10 data set in Chennai were a high percentage of missing readings and a low correlation among daily data recorded by the AQMs. The latter resulted partly because each AQM had a small footprint (approximate area over which the air pollutant measurements recorded in the AQM are considered valid), and partly because of differences in source profiles among the 10 zones within the city. The zones were defined by the Chennai Corporation

  10. Tolerability and Effectiveness of Contact Lenses in Mild Traumatic Brain Injury with Visual Discomfort: A Case Series

    Directory of Open Access Journals (Sweden)

    Len V. Hua, PhD

    2014-01-01

    Full Text Available Background: Over one million people in the United States annually have traumatic incidents that lead to traumatic brain injury (TBI. Asthenopia or eyestrain is frequently a clinical complaint with TBI patients. However, little is studied or known in the literature about the potential of contact lens correction in the management of mild TBI (mTBI with accommodative dysfunction. This pilot study examines the tolerability, effectiveness, and clinical utility of multifocal contact lenses in a subset of mTBI patients with visual discomfort. Methods: This was a controlled, crossover study using Proclear EP Multifocal contact lenses, compared to Proclear Single Vision contact lenses, for five subjects between the ages of 24 and 31 years of age with history of mTBI. Visual symptoms were evaluated using the Convergence Insufficiency Symptom Survey. Visual function was examined by standard visual tests, including visual acuity, extraocular motility (EOM, pupil size, near point of convergence (NPC, vergence, phoria, NRA/PRA, accommodative and vergence facility, and stereoacuity. Subjects were randomized to wear either Proclear Sphere (single vision or Proclear EP Multifocal contact lenses, each for a duration of two weeks. Results: Five mTBI subjects were enrolled in the study. Comprehensive vision examinations of all subjects prior to the study revealed normal ocular health with the exception of visual symptoms such as eyestrain and headache. Two subjects appreciated the beneficial effects of multifocal contact lenses. The other three subjects did not experience substantial benefits of multifocal contact lenses. Nevertheless, all subjects successfully tolerated daylong contact lens wear. Conclusions: Most eye care professionals face the daunting task of how best to manage complex mTBI cases. One of the lingering effects of TBI is often visual symptoms due to oculomotor dysfunction. Multiple treatment modalities may be necessary to alleviate chronic visual

  11. Gravitational effects from a series of IVS R&D VLBI-sessions with observations close to the Sun

    Science.gov (United States)

    Heinkelmann, R.; Soja, B.; Schuh, H.

    2015-08-01

    In 2011 and 2012 the IVS observed twelve VLBI research and development (R&D) sessions that include successful observations as angularly close as 3.9° from the heliocenter. Among others, one purpose of these IVS-R&D sessions was to achieve an improvement in the determination of the PPN parameter γ . Besides, by analyzing this specific set of IVS sessions, it was for the first time possible to measure the dispersive effect of the Solar corona with VLBI (Soja et al., 2014). In this work we assess the formal error of the γ-parameter and the contributions of the various terms to the partial derivative of the γ-parameter. Furthermore, we investigate the size of the gravitational delays caused by: (i) Solar monopole field at rest and with approximately linear translation, (ii) rotation of the Solar monopole field, (iii) Solar gravitational field quadrupole expansion, and (iv) Solar higher order term.

  12. Counterion identity effects on the self-assembly processes in a series of perfluorinated surfactant-water mixtures

    CERN Document Server

    Zhou, R

    2003-01-01

    The effects of counterion on the lyotropic liquid crystalline phase behaviour of some quaternary ammonium salts of perfluorodecanoic acid in water have been studied using a combination of optical polarising microscopy (OPM), deuterium nuclear magnetic resonance ( sup 2 H NMR) and cryo-transmission electron microscopy (cryo-TEM). The results from the phase diagram studies fall into two groups. Firstly the ammonium (A) and tetramethylammonium (TMA) counterions show a phase behaviour with nematic (N) and random mesh (Mh sub 1 (0)) phase which possess non-uniform interfacial curvature. The second group of surfactants with counterions, butyltrimethylammonium (BTMA), dibutyidimetylammonium (DBDMA), and tetrabutylammonium (TEA), form only a classical lamellar phase (L subalpha). For both DBDMA and TBA lower consolute behaviour has been observed. At fixed concentration in all five systems cryo-TEM visualises isotropic liquid phase structures that vary from sphere / rod micelles for A and TMA to vesicles / bilayer pie...

  13. Metabolic acidosis: expected and fatal adverse effects of metformin and empagliflozin: a case series and literature review

    Directory of Open Access Journals (Sweden)

    Miriam Čupić

    2016-09-01

    Full Text Available Metformin, a well-known first-line diabetes therapy, and the recently developed sodium- glucose co-transporter 2 (SGLT2 inhibitor empagliflozin are widely used oral antihyperglycemic drugs in the long-term treatment of type 2 diabetes mellitus (T2DM. Metabolic acidosis is a potentially fatal adverse effect (AE of these drugs with a high mortality rate. However, the reported incidence of metabolic acidosis in clinical practice has been proven to be very low. Nevertheless, it should be considered that the event rates are based on confounded data and spontaneous case reports. Metformin increases plasma lactate levels by inhibiting mitochondrial respiration, which, accompanied by elevated plasma metformin concentrations (in renal impairment and a secondary event that further disrupts lactate production (e.g., hypoperfusion, sepsis, typically leads to metformin-associated lactic acidosis (MALA. At the same time, SGLT2 inhibitors are thought to promote ketogenesis and precipitate ketoacidosis by their extra-pancreatic glucuretic mode of action. The present article describes 3 patients suffering from severe metabolic acidosis caused by metformin or empagliflozin, presents similar cases reported in the literature, and assesses the possible etiopathogenesis of the metabolic derangement. Diabetic patients should be educated about the importance of regular fluid and food intake as well as regular blood and urine glucose and ketone self-checkups, whereas physicians should be more aware that the key to an effective use of all glucose-lowering medication is appropriate patient selection, counseling, and follow-up. It is a good clinical sense which will ensure that physicians are able to translate pharmaceutical advances into clinical benefits for patients with T2DM.

  14. Zn Doping Effect on Magnetic Properties of Znx Cd1-xCr2S4 Systems by High-Temperature Series Expansions

    Institute of Scientific and Technical Information of China (English)

    M. Hamedoun; R. Masrour; K. Bouslykhane; A. Hourmatallah; N. Benzakour; A. Filali

    2007-01-01

    The effect of Zn doping on the magnetic properties of CdCr2S4 systems is studied by mean field theory and high-temperature series expansion (HTSE). The nearest neighbouring and the next-neighbouring super-exchange interactions J1(x) and J2(x) are evaluated for the spinel system ZnxCd1-xCr2S4 in the range 0 ≤ x ≤ 1. The intra-planar and the inter-planar interactions are deduced. The HTSE combined with the Pad?approximant method (PA) is applied to the spinel system ZnxCd1-xCr2S4. Themagnetic phase diagram, i.e. TC versus dilution x, is obtained. The critical exponents associated with the magnetic susceptibility γ and the correlation length v are deduced. The obtained theoretical results are in agreement with the experimental data obtained by magnetic measurements.

  15. Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies.

    Science.gov (United States)

    Casimiro-Garcia, Agustin; Bigge, Christopher F; Davis, Jo Ann; Padalino, Teresa; Pulaski, James; Ohren, Jeffrey F; McConnell, Patrick; Kane, Christopher D; Royer, Lori J; Stevens, Kimberly A; Auerbach, Bruce J; Collard, Wendy T; McGregor, Christine; Fakhoury, Stephen A; Schaum, Robert P; Zhou, Hairong

    2008-05-01

    A new series of alpha-aryl or alpha-heteroarylphenyl propanoic acid derivatives was synthesized that incorporate acetylene-, ethylene-, propyl-, or nitrogen-derived linkers as a replacement of the commonly used ether moiety that joins the central phenyl ring with the lipophilic tail. The effect of these modifications in the binding and activation of PPARalpha and PPARgamma was first evaluated in vitro. Compounds possessing suitable profiles were then evaluated in the ob/ob mouse model of type 2 diabetes. The propylene derivative 40 and the propyl derivative 53 demonstrated robust plasma glucose lowering activity in this model. Compound 53 was also evaluated in male Zucker diabetic fatty rats and was found to achieve normalization of glucose, triglycerides, and insulin levels. An X-ray crystal structure of the complex of 53 with the PPARgamma-ligand-binding domain was obtained and discussed in this report.

  16. A calorimetric investigation of a series of mixed-chain polyunsaturated phosphatidylcholines: effect of sn-2 chain length and degree of unsaturation.

    OpenAIRE

    Niebylski, C D; Salem, N.

    1994-01-01

    Although mammalian tissues contain high levels of polyunsaturated fatty acids, our knowledge of the effects of the degree of unsaturation and double-bond location upon bilayer organization is limited. Therefore, a series of mixed-chain unsaturated phosphatidylcholines (PC) comprised of 18:0 at the sn-1 position and various unsaturates at the sn-2 position (18:1n9, 18:2n6, 18:3n6, 18:3n3, 20:2n6, 20:3n6, 20:4n6, 20:5n3, 22:4n6, 22:5n6, or 22:6n3) was studied with differential scanning calorime...

  17. Biowaiver monographs for immediate release solid oral dosage forms: amodiaquine hydrochloride.

    Science.gov (United States)

    Nair, Anita; Abrahamsson, Bertil; Barends, Dirk M; Groot, D W; Kopp, Sabine; Polli, James E; Shah, Vinod P; Dressman, Jennifer B

    2012-12-01

    The present monograph reviews data relevant to applying the biowaiver procedure for the approval of immediate release (IR) multisource solid dosage forms containing amodiaquine hydrochloride (ADQ) as the single active pharmaceutical ingredient (API). Both biopharmaceutical and clinical data of ADQ were assessed. Solubility studies revealed that ADQ meets the "highly soluble" criteria according to World Health Organization (WHO) and European Medicines Agency (EMA) but fails to comply with the United States Food and Drug Administration (US FDA) specifications. Although metabolism hints at high permeability, available permeability data are too scanty to classify ADQ inequivocably as a Class I drug substance. According to WHO and EMA guidances, ADQ would be conservatively categorized as a Class III drug, whereas according to the US FDA specifications, it would fall into Class IV. ADQ has a wide therapeutic index. Furthermore, no cases of bioinequivalent products have been reported in the open literature. As risks associated with biowaiving appear minimal and requirements for "highly soluble" API are met in the WHO and EMA jurisdictions, the biowaiver procedure can be recommended for bioequivalence (BE) testing of multisource IR products containing ADQ as the only API, provided the test product contains excipients used in ADQ products approved in International Conference of Harmonisation and associated countries, and in similar amounts. Furthermore, both comparator and test should conform to "very rapidly dissolving" product criteria (≥85% dissolution of the API in 15 min at pH 1.2, 4.5, and 6.8) and the labeling should specify that the product not be coadministered with high-fat meals. If the comparator and/or test product fails to meet these criteria, BE needs to be established by pharmacokinetic studies in humans.

  18. Processing and Composition Effects on the Fracture Behavior of Spray-Formed 7XXX Series Al Alloys

    Science.gov (United States)

    Sharma, M. M.; Ziemian, C. W.; Eden, T. J.

    2010-12-01

    The fracture properties of high-strength spray-formed Al alloys were investigated, with consideration of the effects of elemental additions such as zinc, manganese, and chromium and the influence of the addition of SiC particulate. Fracture resistance values between 13.6 and 25.6 MPa (m)1/2 were obtained for the monolithic alloys in the T6 and T7 conditions, respectively. The alloys with SiC particulate compared well and achieved fracture resistance values between 18.7 and 25.6 MPa (m)1/2. The spray-formed materials exhibited a loss in fracture resistance ( K I) compared to ingot metallurgy 7075 alloys but had an improved performance compared to high-solute powder metallurgy alloys of similar composition. Characterization of the fracture surfaces indicated a predominantly intergranular decohesion, possibly facilitated by the presence of incoherent particles at the grain boundary regions and by the large strength differential between the matrix and precipitate zone. It is believed that at the slip band-grain boundary intersection, particularly in the presence of large dispersoids and/or inclusions, microvoid nucleation would be significantly enhanced. Differences in fracture surfaces between the alloys in the T6 and T7 condition were observed and are attributed to inhomogeneous slip distribution, which results in strain localization at grain boundaries. The best overall combination of fracture resistance properties were obtained for alloys with minimum amounts of chromium and manganese additions.

  19. Novel insights on effect of atrioventricular programming of biventricular pacemaker in heart failure – a case series

    Directory of Open Access Journals (Sweden)

    Rafique Asim M

    2006-10-01

    Full Text Available Abstract Background Echocardiography plays an integral role in the diagnosis of congestive heart failure including measurement of left heart pressure as well as mechanical dyssynchrony. Methods In this report we describe novel therapeutic uses of echo pulsed wave Doppler in atrioventricular pacemaker optimization in patients who had either not derived significant symptomatic benefit post biventricular pacemaker implantation or deteriorated after deriving initial benefit. In these patients atrioventricular optimization showed novel findings and improved cardiac output and symptoms. Results In 3 patients with Cheyne Stokes pattern of respiration echo Doppler showed worsening of mitral regurgitation during hyperpneac phase in one patient, marked E and A fusion in another patient and exaggerated ventricular interdependence in a third patient thus highlighting mechanisms of adverse effects of Cheyne Stokes respiration in patients with heart failure. All 3 patients required a very short atrioventricular delay programming for best cardiac output. In one patient with recurrent congestive heart failure post cardiac resynchronization, mitral inflow pulse wave Doppler showed no A wave until a sensed atrioventricular delay of 190 ms was reached and showed progressive improvement in mitral inflow pattern until an atrioventricular delay of 290 ms. In 2 patients atrioventricular delay as short as 50 ms was required to allow E and A separation and prevent diastolic mitral regurgitation. All patients developed marked improvement in congestive heart failure symptoms post echo-guided biv pacemaker optimization. Conclusion These findings highlight the value of echo-guided pacemaker optimization in symptomatic patients post cardiac resynchronization treatment.

  20. A facile pollutant-free approach toward a series of nutritionally effective calcium phosphate nanomaterials for food and drink additives

    Science.gov (United States)

    Wang, Jieru; Chen, Xiaoyi; Yang, Xianyan; Xu, Sanzhong; Zhang, Xinli; Gou, Zhongru

    2011-03-01

    Micronutrient malnutrition is widespread and constitutes one of the main nutritional problems worldwide. Vitamins, amino acids, carbohydrates and Ca-phosphate (CaP) minerals are important to human health and disease prevention. Herein we developed a simple wet-chemical method to prepare multinary nutrients-containing CaP nanomaterials in diluted apple, orange, and grape juices. The scanning electron microscopy observation shows that these nanomaterials are short plate-like CaP nanocrystals of 500 nm in length. The X-ray photoelectron spectroscopy, nitrogen adsorption, thermogravimetric analyses confirm the different specific surface area and organic nutrient contents. The Fourier transform infrared and X-ray diffraction analyses indicate there exist similar organic groups (i.e., COO-, HN-CO) but different CaP species in the precipitates. The dissolution test in vitro simulated stomach juice pH condition indicates that these inorganic-organic nanohybrid materials are multidoped by micronutrients (such as Zn, Sr, Mg, K, vitamin c) and can be readily dissolved in the weak acidic aqueous solutions. This highly efficient utilization of fruit juice to produce CaP-based micronutrient composites may minimize the adverse side effect, so that the nanomaterials are promising as functional food/drink additives. Thus, this novel approach is environmentally and biologically friendly to produce edible nutrients while production cost is attained.

  1. Gene expression time-series analysis of Camptothecin effects in U87-MG and DBTRG-05 glioblastoma cell lines

    Directory of Open Access Journals (Sweden)

    Serra Roberto

    2008-08-01

    Full Text Available Abstract Background The clinical efficacy of camptothecin (CPT, a drug specifically targeting topoisomerase I (TopoI, is under evaluation for the treatment of malignant gliomas. Due to the high unresponsiveness of these tumours to chemotherapy, it would be very important to study the signalling network that drives camptothecin outcome in this type of cancer cells. To address this issue, we had previously compared the expression profile of human U87-MG glioblastoma cells with that of a CPT-resistant counterpart, giving evidence that the development of a robust inflammatory response was the main transcriptional effect associated with CPT resistance. Here we report time-related changes and cell line specific patterns of gene expression after CPT treatment by using two p53 wild-type glioblastoma cell lines, U87-MG and DBTRG-05, with different sensitivities to TopoI inhibition. Results First, we demonstrated that CPT treatment brings the two cell lines to completely different outcomes: accelerated senescence in U87-MG and apoptosis in DBTRG-05 cells. Then, to understand the different susceptibility to CPT, we used oligo-microarray to identify the genes whose expression was regulated during a time-course treatment, ranging from 2 h to 72 h. The statistical analysis of microarray data by MAANOVA (MicroArray ANalysis Of VAriance showed much less modulated genes in apoptotic DBTRG-05 cells (155 with respect to the senescent U87-MG cells (3168, where the number of down-regulated genes largely exceeded that of the up-regulated ones (80% vs. 20%. Despite this great difference, the two data-sets showed a large overlapping (60% circa mainly due to the expression of early stress responsive genes. The use of High-Throughput GoMINER and EASE tools, for functional analysis of significantly enriched GO terms, highlighted common cellular processes and showed that U87-MG and DBTRG-05 cells shared many GO terms, which are related to the down-regulation of cell cycle

  2. Monitoring Effects of Climatic stresses on a Papyrus Wetland System in Eastern Uganda Using Times Series of Remotely Sensed Data

    Science.gov (United States)

    Kayendeke, Ellen; French, Helen K.; Kansiime, Frank; Bamutaze, Yazidhi

    2017-04-01

    Papyrus wetlands predominant in southern, central and eastern Africa; are important in supporting community livelihoods since they provide land for agriculture, materials for building and craft making, as well as services of water purification and water storage. Papyrus wetlands are dominated by a sedge Cyperus papyrus, which is rooted at wetland edges but floats in open water with the help of a root mat composed of intermingled roots and rhizomes. The hypothesis is that the papyrus mat structure reduces flow velocity and increases storage volume during storm events, which not only helps to mitigate flood events but aids in storage of excess water that can be utilised during the dry seasons. However, due to sparse gauging there is inadequate meteorological and hydrological data for continuous monitoring of the hydrological functioning of papyrus systems. The objective of this study was to assess the potential of utilising freely available remote sensing data (MODIS, Landsat, and Sentinel-1) for cost effective monitoring of papyrus wetland systems, and their response to climatic stresses. This was done through segmentation of MODIS NDVI and Landsat derived NDWI datasets; as well as classification of Sentinel-1 images taken in wet and dry seasons of 2015 and 2016. The classified maps were used as proxies for changes in hydrological conditions with time. The preliminary results show that it is possible to monitor changes in biomass, wetland inundation extent, flooded areas, as well as changes in moisture content in surrounding agricultural areas in the different seasons. Therefore, we propose that remote sensing data, when complemented with available meteorological data, is a useful resource for monitoring changes in the papyrus wetland systems as a result of climatic and human induced stresses.

  3. 欧盟传统草药专论述评%Review on community herbal monographs for traditional herbal medicinal products

    Institute of Scientific and Technical Information of China (English)

    邹文俊; 瞿礼萍; 叶祖光; 姬建新; 李伯刚

    2011-01-01

    该文通过对欧盟传统草药专论的建立与评价进行深入分析研究,关注传统草药专论的最新进展,阐明欧盟传统草药专论与简化注册的关系,为我国中药产品欧盟注册提供参考.%This article discusses the characteristics of cmmunity herbal monographs for traditional herbal medicinal products and its establishment procedure. It also reviews the new development of cmmunity traditional herbal monographs. The purpose is to clarify the relationship between cmmunity herbal monographs and simplified registration for traditional herbal medicinal product in European Union and provide reference to the registration of taditional Chinese mdicinal products in Europe.

  4. Series Transmission Line Transformer

    Science.gov (United States)

    Buckles, Robert A.; Booth, Rex; Yen, Boris T.

    2004-06-29

    A series transmission line transformer is set forth which includes two or more of impedance matched sets of at least two transmissions lines such as shielded cables, connected in parallel at one end ans series at the other in a cascading fashion. The cables are wound about a magnetic core. The series transmission line transformer (STLT) which can provide for higher impedance ratios and bandwidths, which is scalable, and which is of simpler design and construction.

  5. Fourier Series Operating Package

    Science.gov (United States)

    Charnow, Milton L.

    1961-01-01

    This report presents a computer program for multiplying, adding, differentiating, integrating, "barring" and scalarly multiplying "literal" Fourier series as such, and for extracting the coefficients of specified terms.

  6. A self-controlled case series to assess the effectiveness of beta blockers for heart failure in reducing hospitalisations in the elderly

    Directory of Open Access Journals (Sweden)

    Pratt Nicole L

    2011-07-01

    Full Text Available Abstract Background To determine the suitability of using the self-controlled case series design to assess improvements in health outcomes using the effectiveness of beta blockers for heart failure in reducing hospitalisations as the example. Methods The Australian Government Department of Veterans' Affairs administrative claims database was used to undertake a self-controlled case-series in elderly patients aged 65 years or over to compare the risk of a heart failure hospitalisation during periods of being exposed and unexposed to a beta blocker. Two studies, the first using a one year period and the second using a four year period were undertaken to determine if the estimates varied due to changes in severity of heart failure over time. Results In the one year period, 3,450 patients and in the four year period, 12, 682 patients had at least one hospitalisation for heart failure. The one year period showed a non-significant decrease in hospitalisations for heart failure 4-8 months after starting beta-blockers, (RR, 0.76; 95% CI (0.57-1.02 and a significant decrease in the 8-12 months post-initiation of a beta blocker for heart failure (RR, 0.62; 95% CI (0.39, 0.99. For the four year study there was an increased risk of hospitalisation less than eight months post-initiation and significant but smaller decrease in the 8-12 month window (RR, 0.90; 95% CI (0.82, 0.98. Conclusions The results of the one year observation period are similar to those observed in randomised clinical trials indicating that the self-controlled case-series method can be successfully applied to assess health outcomes. However, the result appears sensitive to the study periods used and further research to understand the appropriate applications of this method in pharmacoepidemiology is still required. The results also illustrate the benefits of extending beta blocker utilisation to the older age group of heart failure patients in which their use is common but the evidence is

  7. A series of meta-analytic tests of the depletion effect: Self-control does not seem to rely on a limited resource.

    Science.gov (United States)

    Carter, Evan C; Kofler, Lilly M; Forster, Daniel E; McCullough, Michael E

    2015-08-01

    Failures of self-control are thought to underlie various important behaviors (e.g., addiction, violence, obesity, poor academic achievement). The modern conceptualization of self-control failure has been heavily influenced by the idea that self-control functions as if it relied upon a limited physiological or cognitive resource. This view of self-control has inspired hundreds of experiments designed to test the prediction that acts of self-control are more likely to fail when they follow previous acts of self-control (the depletion effect). Here, we evaluated the empirical evidence for this effect with a series of focused, meta-analytic tests that address the limitations in prior appraisals of the evidence. We find very little evidence that the depletion effect is a real phenomenon, at least when assessed with the methods most frequently used in the laboratory. Our results strongly challenge the idea that self-control functions as if it relies on a limited psychological or physical resource. (c) 2015 APA, all rights reserved).

  8. In vitro binding affinities of a series of flavonoids for μ-opioid receptors. Antinociceptive effect of the synthetic flavonoid 3,3-dibromoflavanone in mice.

    Science.gov (United States)

    Higgs, Josefina; Wasowski, Cristina; Loscalzo, Leonardo M; Marder, Mariel

    2013-09-01

    The pharmacotherapy for the treatment of pain is an active area of investigation. There are effective drugs to treat this problem, but there is also a need to find alternative treatments free of undesirable side effects. In the present work the capacity of a series of flavonoids to bind to the μ opioid receptor was evaluated. The most active compound, 3,3-dibromoflavanone (31), a synthetic flavonoid, presented a significant inhibition of the binding of the selective μ opioid ligand [(3)H]DAMGO, with a Ki of 0.846 ± 0.263 μM. Flavanone 31 was further synthesized using a simple and cheap procedure with good yield. Its in vivo effects in mice, after acute treatments, were studied using antinociceptive and behavioral assays. It showed no sedative, anxiolytic, motor incoordination effects or inhibition of the gastrointestinal transit in mice at the doses tested. It evidenced antinociceptive activity on the acetic acid-induced nociception, hot plate and formalin tests (at 10 mg/kg and 30 mg/kg). The results showed that the 5-HT2 receptor and the adrenoceptors seem unlikely to be involved in its antinociceptive effects. Naltrexone, a nonselective opioid receptors antagonist, totally blocked compound 31 antinociceptive effects on the hot plate test, but naltrindole (δ opioid antagonist) and nor-binaltorphimine (κ opioid antagonist) did not. These findings demonstrated that 3,3-dibromoflavanone (31), at doses that did not interfere with the motor performance, exerted clear dose dependent antinociception when assessed in the chemical and thermal models of nociception in mice and it seems that its action is related to the activation of the μ opioid receptor.

  9. Seri Kinship Terminology.

    Science.gov (United States)

    Moser, Mary B.; Marlett, Stephen A.

    The Seri language contains over 50 kinship terms and represents one of the most highly elaborated kinship systems described to date. This paper discusses Seri kinship terminology and centers around, but is not limited to, the set of obligatory possessed noun stems that are inflected with the following possessive prefixes": "hi-,""ma-," and "a-."…

  10. Time Series Momentum

    DEFF Research Database (Denmark)

    Moskowitz, Tobias J.; Ooi, Yao Hua; Heje Pedersen, Lasse

    2012-01-01

    under-reaction and delayed over-reaction. A diversified portfolio of time series momentum strategies across all asset classes delivers substantial abnormal returns with little exposure to standard asset pricing factors and performs best during extreme markets. Examining the trading activities...... of speculators and hedgers, we find that speculators profit from time series momentum at the expense of hedgers....

  11. Periodic Time Series Models

    NARCIS (Netherlands)

    Ph.H.B.F. Franses (Philip Hans); R. Paap (Richard)

    2004-01-01

    textabstractThis book considers periodic time series models for seasonal data, characterized by parameters that differ across the seasons, and focuses on their usefulness for out-of-sample forecasting. Providing an up-to-date survey of the recent developments in periodic time series, the book

  12. Fourier Series Optimization Opportunity

    Science.gov (United States)

    Winkel, Brian

    2008-01-01

    This note discusses the introduction of Fourier series as an immediate application of optimization of a function of more than one variable. Specifically, it is shown how the study of Fourier series can be motivated to enrich a multivariable calculus class. This is done through discovery learning and use of technology wherein students build the…

  13. Therapeutic Effects of Saireito (Chai-Ling-Tang, a Traditional Japanese Herbal Medicine, on Lymphedema Caused by Radiotherapy: A Case Series Study

    Directory of Open Access Journals (Sweden)

    Aiko Nagai

    2013-01-01

    Full Text Available Despite the development of radiotherapy machines and technologies, a proportion of patients suffer from radiation-induced lymphedema. Saireito (SRT is a traditional Japanese herbal medicine that has been used for treating edema and inflammation in conditions such as nephritic disease. This study investigated the effect of SRT on lymphedema caused by radiotherapy. Four patients were treated with SRT at a dose of 9 g/day. The severity of lymphedema was evaluated using the Common Terminology Criteria for Adverse Events version 4 and Numerical Rating Scale before and after SRT treatment. After the treatment with SRT, 2 of 4 patients (50% showed apparent improvement in lymphedema. One of the cases had difficulty in wearing the custom-made thermoplastic cast, but after SRT administration, he could wear the mask easily. One case decided to stop taking SRT 3 days after initiation because cough and fever appeared. In conclusion, it is important to control the side effects of radiotherapy, which leads to improved tumor control rates. Prospective randomized studies are necessary to confirm the findings of this case series study.

  14. Cut-off effect in antimicrobial activity and in membrane perturbation efficiency of the homologous series of N,N-dimethylalkylamine oxides.

    Science.gov (United States)

    Devínsky, F; Kopecka-Leitmanová, A; Sersen, F; Balgavý, P

    1990-11-01

    The antimicrobial activity of the homologous series of N,N-dimethylalkylamine oxides (DMAO) was found to be quasi parabolically dependent on alkyl chain length with a maximum at n approximately 15 and n approximately 12 for Staphylococcus aureus and Escherichia coli, respectively. The physiochemical properties of DMAOs as characterized by critical micelle concentrations, retention times of 1-alkenes generated from DMAOs by gas-liquid chromatography, Rm values in reversed phase chromatography, and bacterial lipid/aqueous phase partition coefficients were found to correlate with the alkyl chain length. The effect of DMAOs on the structure of the model membrane prepared from isolated lipids from Escherichia coli as detected by a spin probe method was maximal for the alkyl chain length n approximately 10-12 coinciding with the maximum in the antimicrobial activity observed with Escherichia coli. It is suggested that the cut-off in the DMAO antimicrobial activity is caused by the cut-off in the DMAO perturbing effect on the membrane structure.

  15. Effect of particulate matter less than 10μm (PM10 on mortality in Bogota, Colombia: a time-series analysis, 1998-2006

    Directory of Open Access Journals (Sweden)

    Luis Camilo Blanco-Becerra

    2014-07-01

    Full Text Available Objective. To analyze the association between daily mortality from different causes and acute exposure to particulate matter less than 10 microns in aerodynamic diameter (PM10, in Bogota, Colombia. Materials and methods. A time-series ecological study was conducted from 1998 to 2006. The association between mortality (due to different causes and exposure was analyzed using single and distributed lag models and adjusting for potential confounders. Results. For all ages, the cumulative effect of acute mortality from all causes and respiratory causes increased 0.71% (95%CI 0.46-0.96 and 1.43% (95%CI 0.85-2.00, respectively, per 10μg/m3 increment in daily average PM10 with a lag of three days before death. Cumulative effect of mortality from cardiovascular causes was -0.03% (95%CI -0.49-0.44% with the same lag. Conclusions. The results suggest an association between an increase in PM10 concentrations and acute mortality from all causes and respiratory causes.

  16. Inter-laboratory verification of European pharmacopoeia monograph on derivative spectrophotometry method and its application for chitosan hydrochloride.

    Science.gov (United States)

    Marković, Bojan; Ignjatović, Janko; Vujadinović, Mirjana; Savić, Vedrana; Vladimirov, Sote; Karljiković-Rajić, Katarina

    2015-01-01

    Inter-laboratory verification of European pharmacopoeia (EP) monograph on derivative spectrophotometry (DS) method and its application for chitosan hydrochloride was carried out on two generation of instruments (earlier GBC Cintra 20 and current technology TS Evolution 300). Instruments operate with different versions of Savitzky-Golay algorithm and modes of generating digital derivative spectra. For resolution power parameter, defined as the amplitude ratio A/B in DS method EP monograph, comparable results were obtained only with algorithm's parameters smoothing points (SP) 7 and the 2nd degree polynomial and those provided corresponding data with other two modes on TS Evolution 300 Medium digital indirect and Medium digital direct. Using quoted algorithm's parameters, the differences in percentages between the amplitude ratio A/B averages, were within accepted criteria (±3%) for assay of drug product for method transfer. The deviation of 1.76% for the degree of deacetylation assessment of chitosan hydrochloride, determined on two instruments, (amplitude (1)D202; the 2nd degree polynomial and SP 9 in Savitzky-Golay algorithm), was acceptable, since it was within allowed criteria (±2%) for assay deviation of drug substance, for method transfer in pharmaceutical analyses. Copyright © 2015 Elsevier B.V. All rights reserved.

  17. The effect of core stability training on balance and mobility in ambulant individuals with multiple sclerosis: a multi-centre series of single case studies.

    Science.gov (United States)

    Freeman, J A; Gear, M; Pauli, A; Cowan, P; Finnigan, C; Hunter, H; Mobberley, C; Nock, A; Sims, R; Thain, J

    2010-11-01

    Core stability training is popular in the management of people with multiple sclerosis (MS); however, scientific evidence to support its effectiveness is scarce. To explore the effectiveness of core stability training on balance and mobility. A multi-centre series of eight single case studies was undertaken. Eight ambulant individuals with stable MS participated in 16 face-to-face core stability training sessions, delivered by a neurophysiotherapist, plus a daily home exercise programme. A range of outcomes were measured: 10-m timed walk, 12-item MS walking scale, timed get up and go, functional reach tests, timed single leg stance, visual analogue scales of two activities, and the Activities-specific Balance Confidence Scale. Visual analysis of trend, level and slope demonstrated improvement in five subjects (62%) in seven measures. This was confirmed by the two standard deviation band method of analysis for six measures. Analysis of group data (repeated measures within subjects analysis of variance) indicated significant improvement between baseline and intervention phases for timed walk (p = 0.019), MSWS-12 Scale (p = 0.041), forward (p = 0.015) and lateral reach (p = 0.012). In general, no further improvements were made following withdrawal of the intervention. This study provides preliminary evidence of the effectiveness of an 8-week core stability training programme in improving balance and mobility in ambulant people with MS. Variations in response to intervention are evident. Assessor-blinded randomized controlled studies are required to confirm these findings and determine patient characteristics which identify those who benefit most from this intervention.

  18. One-year delayed effect of fog on malaria transmission: a time-series analysis in the rain forest area of Mengla County, south-west China

    Directory of Open Access Journals (Sweden)

    Goggins William B

    2008-06-01

    Full Text Available Abstract Background Malaria is a major public health burden in the tropics with the potential to significantly increase in response to climate change. Analyses of data from the recent past can elucidate how short-term variations in weather factors affect malaria transmission. This study explored the impact of climate variability on the transmission of malaria in the tropical rain forest area of Mengla County, south-west China. Methods Ecological time-series analysis was performed on data collected between 1971 and 1999. Auto-regressive integrated moving average (ARIMA models were used to evaluate the relationship between weather factors and malaria incidence. Results At the time scale of months, the predictors for malaria incidence included: minimum temperature, maximum temperature, and fog day frequency. The effect of minimum temperature on malaria incidence was greater in the cool months than in the hot months. The fog day frequency in October had a positive effect on malaria incidence in May of the following year. At the time scale of years, the annual fog day frequency was the only weather predictor of the annual incidence of malaria. Conclusion Fog day frequency was for the first time found to be a predictor of malaria incidence in a rain forest area. The one-year delayed effect of fog on malaria transmission may involve providing water input and maintaining aquatic breeding sites for mosquitoes in vulnerable times when there is little rainfall in the 6-month dry seasons. These findings should be considered in the prediction of future patterns of malaria for similar tropical rain forest areas worldwide.

  19. Outliers Mining in Time Series Data Sets

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    In this paper, we present a cluster-based algorithm for time series outlier mining.We use discrete Fourier transformation (DFT) to transform time series from time domain to frequency domain. Time series thus can be mapped as the points in k-dimensional space.For these points, a cluster-based algorithm is developed to mine the outliers from these points.The algorithm first partitions the input points into disjoint clusters and then prunes the clusters,through judgment that can not contain outliers.Our algorithm has been run in the electrical load time series of one steel enterprise and proved to be effective.

  20. Application of Power Series on Vibration Analyses

    Institute of Scientific and Technical Information of China (English)

    沈永刚

    2003-01-01

    Power series is extensively used for engineering studies. To raise the synthesis efficiency and computation accuracy of vibration mode synthesis (MS), the choosing of power series as the component mode-function is studied in this paper, and emphasis is laid on its effect upon the system computation accuracy when using the mode synthesis method for a high speed compound rotating elastic system.