Government and technological innovation - Weather modification as a case in point.

Science.gov (United States)

Lambright, W. H.

1972-01-01

The principal technology on which all forms of intentional, local weather modification ultimately rest is that of cloud seeding. There are three primary milestones in the evolution of such a new technology including invention, development, and introduction to society on an operational basis. It is shown that government has been deeply involved in each of the first two phases of weather modification's evolution. The agencies involved include the military agencies, the Weather Bureau, the National Science Foundation, and the Bureau of Reclamation. It is pointed out that weather modification will require some unusually flexible and open administrative devices if it is to advance in the public interest.

JOYO modification program for demonstration tests of FBR innovative technology development

International Nuclear Information System (INIS)

Yoshimi, H.; Hachiya, Y.

1990-01-01

A plan is under way at PNC to modify the experimental fast reactor JOYO. The project is called MARK-III (MK-III) program. The purpose of MK-III is to expand the function of JOYO, and to make it possible to receive demonstration tests of new or high level technologies for FBR development. The MK-III program consists of two main modifications: conversion to a highly efficient irradiation facility; and a modification for demonstration testing of new technologies and concepts that have a high potential to reduce FBR plant construction cost, to evaluate plant reliability and to improve plant safety. These modifications are scheduled to start in 1991

Classical elements in the endowments of Serbian XIII century donors

Directory of Open Access Journals (Sweden)

Gligorijević-Maksimović Mirjana

2009-01-01

Full Text Available In Byzantine painting, starting from the XIII and particularly during the XIV century, there was a visible return to models from the period of Antiquity. The influences of ancient, ostensibly, Hellenistic heritage were reflected in the shapes, in the content of the compositions, as well as in the drawing, modellation and colours. In the art that came into being in the course of the XIII century, in the endowments of the Serbian donors numerous elements emerged that had existed in ancient art. In the frescoes in the Church of the Mother of God in Studenica, the endowment of Stefan Nemanja and his sons, we see personifications, symbols, the introduction of details, and space acquiring depth, features that were later to come to full expression, especially from the middle of the XIII century. The few preserved frescoes dating from the XIII century in the Church of the Resurrection in the Žiča monastery, the endowment of Stefan the First Crowned, his son Radoslav and his brother Sava, are an iconographic continuation of the trends in the art one encounters in Studenica. The frescoes in the Church of Christ's Ascension in Mileševa, the endowment of King Vladislav, with their subtly fashioned figures and carefully modelled faces, as well as refined colouring, signal a return to the Hellenistic models. The painting in the Church of Dormition of the Virgin in the Morača monastery, the endowment of Prince Stefan, nephew of king Stefan, with its well-proportioned, firmly modelled figures, landscapes and architecture deepening the space, reminds one of the Sopoćani frescoes. In the fresco painting of the Holy Apostles in Peć, the endowment of Archbishop Sava which owed its outcome to the efforts of Archbishop Arsenije I, the images are very vivid, and the painted architecture is depicted in an abbreviated form, using different kinds of perspective. The painting in the Church of the Holy Trinity in Sopoćani, the endowment of king Uroš I, represents

Plasma assisted surface coating/modification processes: An emerging technology

Science.gov (United States)

Spalvins, T.

1986-01-01

A broad understanding of the numerous ion or plasma assisted surface coating/modification processes is sought. An awareness of the principles of these processes is needed before discussing in detail the ion nitriding technology. On the basis of surface modifications arising from ion or plasma energizing and interactions, it can be broadly classified as deposition of distinct overlay coatings (sputtering-dc, radio frequency, magnetron, reactive; ion plating-diode, triode) and surface property modification without forming a discrete coating (ion implantation, ion beam mixing, laser beam irradiation, ion nitriding, ion carburizing, plasma oxidation). These techniques offer a great flexibility and are capable in tailoring desirable chemical and structural surface properties independent of the bulk properties.

Plasma assisted surface coating/modification processes - An emerging technology

Science.gov (United States)

Spalvins, T.

1987-01-01

A broad understanding of the numerous ion or plasma assisted surface coating/modification processes is sought. An awareness of the principles of these processes is needed before discussing in detail the ion nitriding technology. On the basis of surface modifications arising from ion or plasma energizing and interactions, it can be broadly classified as deposition of distinct overlay coatings (sputtering-dc, radio frequency, magnetron, reactive; ion plating-diode, triode) and surface property modification without forming a discrete coating (ion implantation, ion beam mixing, laser beam irradiation, ion nitriding, ion carburizing, plasma oxidation. These techniques offer a great flexibility and are capable in tailoring desirable chemical and structural surface properties independent of the bulk properties.

The Spanish King Alfonso XIII on pages of Russian Press in 1902–1917

Directory of Open Access Journals (Sweden)

Ariadna A. Petrova

2016-06-01

Full Text Available The article examines the approaches of the Russian press (“Moskovskie Vedomosti”, “Russkie Vedomosti”, “Novoe Vremia” to the evaluation of the Spanish King Alfonso XIII (1886–1941 at the first stage of his government. During this time he, acting within the powers granted to him by the Spanish constitution of the Restoration era, tried to stabilize the political situation in Spain and raise the prestige of the royal power, is also actively involved in social and political life of the country. Alfonso XIII also sought to raise the country's prestige in the international arena, seriously shaken after the “disaster in 1898”. The special attention is paid to the problem of formation of public opinion by the Russian press, on the example of newspaper coverage of humanitarian and intermediate activity of the Spanish king during the First World War. The activity of Alfonso XIII, aimed at protecting the interests of the citizens of the Russian Empire and the Slavic population of Austria-Hungary, in particular, his personal involvement in the rescue of the Austrian authorities was sentenced to death by a correspondent of the newspaper "New time" in Vienna D.G. Yanchevetskiy, forced the Russian public during the war to change the attitude towards Spain, its king and Spanish neutrality.

What history tells us XIII. Fifty years of the Central Dogma

Indian Academy of Sciences (India)

2008-05-14

May 14, 2008 ... Home; Journals; Journal of Biosciences; Volume 33; Issue 2. What history tells us XIII. Fifty years of the Central Dogma. Michel Morange. Series Volume 33 Issue 2 June 2008 pp 171-175. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/033/02/0171-0175 ...

Potential benefits of genetic modification (GM) technology for food ...

African Journals Online (AJOL)

We assessed the perception of farmers towards potential adoption of genetic modification (GM) technology for improving health, food security and agricultural productivity using a semi-structured interview. A total sample of 54 small-scale farmers participated in 6 focus group meetings (FGMs) and 23 in-depth interviews at ...

Ressenya a Ovidio Cuella Esteban i Juan B. Simó Castillo, Bulario de Benedicto XIII (1394-1423. VI. Diócesis de Tortosa. Maestrazgo de Santa María de Montesa. Testamento de Benedicto XIII, Peníscola, Associació ‘Amics del Papa Luna’, 2013, pp. 680, ISBN 978-84-616-7651-4

Directory of Open Access Journals (Sweden)

Blai Josep Server Server

2014-12-01

Full Text Available Review to Ovidio Cuella Esteban i Juan B. Simó Castillo, Bulario de Benedicto XIII (1394-1423. VI. Diócesis de Tortosa. Maestrazgo de Santa María de Montesa. Testamento de Benedicto XIII, Peníscola, Associació ‘Amics del Papa Luna’, 2013, pp. 680, ISBN 978-84-616-7651-4

Enzyme Technology of Peroxidases: Immobilization, Chemical and Genetic Modification

Science.gov (United States)

Longoria, Adriana; Tinoco, Raunel; Torres, Eduardo

An overview of enzyme technology applied to peroxidases is made. Immobilization on organic, inorganic, and hybrid supports; chemical modification of amino acids and heme group; and genetic modification by site-directed and random mutagenesis are included. Different strategies that were carried out to improve peroxidase performance in terms of stability, selectivity, and catalytic activity are analyzed. Immobilization of peroxidases on inorganic and organic materials enhances the tolerance of peroxidases toward the conditions normally found in many industrial processes, such as the presence of an organic solvent and high temperature. In addition, it is shown that immobilization helps to increase the Total Turnover Number at levels high enough to justify the use of a peroxidase-based biocatalyst in a synthesis process. Chemical modification of peroxidases produces modified enzymes with higher thermostability and wider substrate variability. Finally, through mutagenesis approaches, it is possible to produce modified peroxidases capable of oxidizing nonnatural substrates with high catalytic activity and affinity.

[Religion and healing in the XIII century: some considerations about therapy and holy medical observations in Iacopo da Varagine's Cronica Civitatis Ianuensis].

Science.gov (United States)

Moggia, Carlo

2004-01-01

The article is dedicated to recovery and holy therapy in Medieval society. In the XIII century Roman Church define the religious observations of physical and spiritual healing: the intervention of Saints and their holy miracles is very important for a perfect recovery. The article analyse the holy therapy through the study of the Cronica Civitatis Ianuensis read by the Dominican friar Iacopo da Varagine, at the end of the XIII century. This work represents one of the most important literary and hagiographic instrument to comprehend medical medieval imaginary.

Red portuaria y control marítimo en el reino de Valencia (siglos XIII-XV)

OpenAIRE

Igual Luis, David

2013-01-01

El trabajo aborda la progresiva creación de una red portuaria en el litoral valenciano de los siglos XIII-XV y, a partir de ella, el desarrollo de diversos instrumentos de control marítimo que atendían a principios políticos, legales, infraestructurales y hasta territoriales.

Gyvulininkystė pietryčių Lietuvoje XIII-XIV a

OpenAIRE

Vitkūnas, Manvydas

2006-01-01

Gyvulininkystė XIII-XIV a. buvo viena svarbiausių ūkio šakų. Pietryčių Lietuvos archeologiniuose paminkluose surinktos osteologinės medžiagos tyrimų duomenimis, naminiai gyvuliai daugeliui gyventojų buvo pagrindiniu mėsos šaliniu. Pietryčių Lietuvos archeologiniuose paminkluose (Nemenčinės, Bradeliškių, Maišiagalos, Aukštadvario piliakalniuose, viduramžių Kernavės miesto vietoje, Vilniaus žemutinėje pilyje) naminių gyvulių kaulai sudarė dažniausiai 80-95%, o Maišiagalos piliakalnyje – net 99%...

Modification of Wastewater Treatment Technology at Cottonseed Oil Plant

Directory of Open Access Journals (Sweden)

Alshabab Mary Shick

2016-01-01

Full Text Available Wastewaters from cottonseed oil producing plant in Syria were studied in laboratory experiments. Aim of the study was to suggest modification of wastewater treatment technology in order to increase its efficiency. Concentration of pollutants in wastewaters was controlled by measurement of COD. According to the results of experiments it was suggested to decrease significantly (8-20 times dosages of reagents (acidifier, coagulant, flocculant in several actual stages of treatment (acidification, separation, coagulation and sedimentation and add stage of dispersed air flotation before coagulation treatment. The modified wastewater treatment technology would reduce COD to the values allowed for irrigation waters by Syrian National Standard.

Factor XIII Val34Leu is a genetic factor involved in the etiology of venous thrombosis

NARCIS (Netherlands)

Franco, R. F.; Reitsma, P. H.; Lourenço, D.; Maffei, F. H.; Morelli, V.; Tavella, M. H.; Araújo, A. G.; Piccinato, C. E.; Zago, M. A.

1999-01-01

A mutation in the factor XIII gene (FXIII Val34Leu) gene was recently reported to confer protection against myocardial infarction, but its relationship with venous thrombosis is unknown. In addition, a mutation in the 5'-untranslated region of the FXII gene (46 C->T) was identified which is

Tactic "Tulgama" the Art of War the Mongols XIII century

Directory of Open Access Journals (Sweden)

Leonid A. Bobrov

2015-12-01

Full Text Available In this publication, based on a comprehensive analysis of the sources, considered one of the most important tactics of the Mongols of the XIII century, known under the Turkic name "Tulgama". The name of the maneuver is derived from the Turkic verb "talamak", meaning "to surround, to wrapped up, to turn, to whirl, to twist". It is established that the maneuver "Tulgama" was a special tactic, providing coverage flank (flanks of the enemy in the rear and the application of massed archery shot in his builds. Selected three varieties under consideration tactic: right flank or left flank and steam room (double "Tulgama". The most typical was right flanks "Tulgama" when doing the nomads, covered the left wing of the enemy with its right flank. This allowed the attacking archers to fire from the most convenient position (left-forward, left, and left-back. A characteristic feature of the Mongol tactical art was a steam room (double "Tulgama" when the troops of nomads covered both enemy's flank, concluding the enemy's army in the ring, then attacked her from all four sides. A similar technique could not only shoot down from the position, but almost completely destroy the enemy troops. For the most efficient use of maneuver "Tulgama" the Mongols made increasing use of expanded mesalamines system, with a powerful thrust forward flank groups. The concentration of the shock troops on the flanks (reinforced, including by weakening the Central shelf is dramatically different from the tactics of the Mongols from the traditional tactics of the Turks, whose best part was typically the center of the combat formations. However, direct confrontation of these two approaches during the military campaigns of the XIII century demonstrated the advantages of the Mongol tactical schemes. High efficiency of reception "Tulgama" led to its continued existence in the military art of the nomads.

Las tesis de los filósofos del siglo XIII que afirmaron la existencia del intelecto agente

Directory of Open Access Journals (Sweden)

Sellés, Juan Fernando

2008-06-01

Full Text Available In this article we review the statements of relevant philosophers of the XIII^eme century supporting the existence of the human agent intellect. Three groups can be distinguished: I The universal hylemorphism (Alexander of Hales, John de la Rochelle, Mathew of Acquasparta; II The synthesis between the augustinianism and the aristhotelism (Peter Hispanus, Saint Bonaventura, John Peckham; III The purified and advanced aristotelism (Albert the Great, Thomas Aquinas, Ramon Llull.

En este trabajo se revisan las tesis de relevantes filósofos del s. XIII que defendieron la existencia del intelecto agente en el hombre. En el trabajo se dividen en tres grupos a los pensadores: I Los que se suelen encuadrar dentro del llamado hilemorfismo universal (Alejandro de Hales, Juan de la Rochela y Mateo de Acquasparta. II La síntesis entre el agustinismo y el aristotelismo (Pedro Hispano, San Buenaventura, Juan Peckham. III El aristotelismo depurado y proseguido (San Alberto Magno, Sto. Tomás de Aquino, Ramón Llull.

Biomaterials modification by ion beam

International Nuclear Information System (INIS)

Zhang Tonghe; Yi Zhongzhen; Zhang Xu; Wu Yuguang

2001-01-01

Ion beam technology is one of best ways for the modification of biomaterials. The results of ion beam modification of biomaterials are given. The method and results of improved biocompatibility are indicated by ion beam technology. The future development of ion beam modification of biomaterials is discussed

4p-5s transitions in In XIII, In XIV and In XV

International Nuclear Information System (INIS)

Carroll, P.K.; Costello, J.T.; O'Sullivan, G.

1986-01-01

The spectrum of an indium plasma produced by a 1.5 J, 25 ns ruby laser was recorded in the XUV. At wavelengths below 100 A, the spectrum is dominated by 4p-5s transitions in a number of ion stages. Many lines arising from 4p 6 4d-4p 5 4d5s, 4p 6 -4p 5 5s and 4p 5 -4p 4 5s transitions in In XIII, In XIV and In XV have been identified by isoelectronic extrapolation and Dirac-Fock calculations. (orig.)

I governi di “popolo” e le istituzioni comunali nella seconda metà del secolo XIII

Directory of Open Access Journals (Sweden)

Enrico Artifoni

2003-12-01

Full Text Available Nella seconda metà del secolo XIII la cultura politica dei governi popolari si esprime in modo articolato e consapevole attraverso molteplici scelte: l’istituzione di organismi collegiali ristretti, la valorizzazione delle forme associative di quartiere o di rione, la “domanda” rivolta al ceto notarile di elaborare forme documentarie adeguate a un assetto istituzionale complesso qual era quello del comune duecentesco.

Traditional and New Enhancing Human Cybernetic and Nanotechnological Body Modification Technologies: A Comparative Study of Roman Catholic and Transhumanist Ethical Approaches

Science.gov (United States)

Caligiuri, Michael J.

Advances in cybernetic and nanotechnological body modifications currently allow for enhancements to human physical and mental function which exceed human species-based norms. This thesis examines body modification and human enhancement from two perspectives---Roman Catholicism and Transhumanism--- in order to contribute to bioethical deliberations regarding enhancement technologies. Roman Catholicism has a longstanding tradition of bioethical discourse, informing the healthcare directives of Roman Catholic institutions. Transhumanism is more recent movement that endorses body modifications and human enhancements as a means of individual betterment and social evolution. The thesis first considers definitions of human enhancement and levels of normalcy in connection to cybernetic and nanotechnological bionic implants, and outlines a series of criteria to assess a technology's potential bioethical acceptability: implantability, permanency, power, and public interaction. The thesis then describes Roman Catholicism's response to non-enhancing decorative body modifications (cosmetic surgeries, common decorative modifications such as tattoos and piercings, and uncommon modifications such as scarifications and brandings) in order to establish a basis for possible Roman Catholic responses to enhancing cybernetic and nanotechnological modifications. This is followed by an analysis from a Roman Catholic perspective of the major social issues brought forward by enhancement technologies: commodification, eugenics, vulnerability, and distributive justice. Turning to Transhumanism, the thesis describes the origins and philosophy of the movement, and then discusses the bioethical principles it advances with regard to human enhancement. The thesis concludes by locating points of convergence between Transhumanism and Roman Catholicism that could be the basis of more widely accepted ethical guidelines regarding modification technologies.

Patho-epidemiological study on Genotype-XIII Newcastle disease virus infection in commercial vaccinated layer farms

Directory of Open Access Journals (Sweden)

J. H. Khorajiya

2015-03-01

Full Text Available Aim: The present research work was carried out to study the patho-epidemiological aspects of Genotype-XIII Newcastle disease virus (NDV infection in commercial layer in and around Anand, Gujarat. As the outbreaks have reported in vaccinated flocks, it was felt necessary to study the disease with respect to its changing pathogenicity and relevant aspects. Materials and Methods: The study comprised of patho-epidemiology of Newcastle disease (ND by information collected from different layer farms suffering from the disease in relation to incidence pattern and mortality, duration of mortality, susceptible age, and loss due to production performance. Clinical signs were recorded based on observations. During postmortem, gross lesions were also recorded. For histopathological examination visceral organs according to lesions were collected in 10% formalin and processed slide stained by hematoxylin and eosin for microscopic examination. Cultivation of virus was done in embryonated specific pathogen-free (SPF eggs of 9-11 days and isolation of virus was done for haemagglutination (HA and haemagglutination inhibition (HI test and to identify pathotype of virus by intracerebral pathogenicity index (ICPI test to determine the virulence of virus. The Genotype-XIII NDV was confirmed by F gene sequence and whole genome sequence. Results: During the study mortality due to ND was recorded in 13 layer flocks in spite of routine vaccination, which usually contain Genotype-II strain of virus. The mortality was observed as high as above 50% with an average of 21.21%. The susceptible age for disease was found to be 6-14 weeks. The duration of mortality observed was 23 days. The disease resulted in a significant reduction in body weight, feed intake and drop in egg production. Majority of the outbreaks appeared during extremely hot months of April to June. Greenish diarrhoea was frequently seen in birds that survived early in infection. Mortality continued for 2

Venezuela-MEM/USA-DOE Fossil Energy Report XIII-1, Supporting Technology for Enhanced Oil Recovery, Microbial EOR

Energy Technology Data Exchange (ETDEWEB)

Ziritt, Jose Luis

1999-11-03

The results from Annex XIII of the Cooperative Agreement between the United States Department of Energy (DOE) and the Ministry of Energy and Mines of the Republic of Venezuela (MEMV) have been documented and published with many researchers involved. Integrate comprehensive research programs in the area of Microbial Enhanced Oil Recovery (MEOR) ranged from feasibility laboratory studies to full-scale multi-well field pilots. The objective, to cooperate in a technical exchange of ideas and information was fully met throughout the life of the Annex. Information has been exchanged between the two countries through published reports and technical meetings between experts in both country's research communities. The meetings occurred every two years in locations coincident with the International MEOR conferences & workshops sponsored by DOE (June 1990, University of Oklahoma, September 1992, Brookhaven, September 1995, National Institute of Petroleum and Energy Research). Reports and publications produced during these years are listed in Appendix B. Several Annex managers have guided the exchange through the years. They included Luis Vierma, Jose Luis Zirritt, representing MEMV and E. B. Nuckols, Edith Allison, and Rhonda Lindsey, representing the U.S. DOE. Funding for this area of research remained steady for a few years but decreased in recent years. Because both countries have reduced research programs in this area, future exchanges on this topic will occur through ANNEX XV. Informal networks established between researchers through the years should continue to function between individuals in the two countries.

L'escriptura i el llibre a la Catalunya Central als segles XIII i XIV

OpenAIRE

Torras i Cortina, Miquel

2004-01-01

Consultable des del TDX Títol obtingut de la portada digitalitzada Aquesta investigació reconstrueix la vida cultural de la ciutat de Manresa, a la Catalunya Central, al llarg dels segles XIII i XIV, amb el còdex baixmedieval com a fil conductor. L'estudi es basa en l'anàlisi de 305 documents amb mencions libràries (editats conjuntament), pràcticament tots ells inèdits, que procedeixen d'un buidatge exhaustiu dels fons notarials que custodien l'Arxiu Històric Comarcal de Manresa i l'Arx...

Ion bombardment modification of surfaces

International Nuclear Information System (INIS)

Auciello, O.

1984-01-01

Ion bombardment-induced modification of surfaces may be considered one of the significant scientific and technological developments of the last two decades. The understanding acquired concerning the underlying mechanisms of several phenomena occurring during ion-surface interactions has led to applications within different modern technologies. These include microelectronics, surface acoustical and optical technologies, solar energy conversion, thin film technology, ion implantation metallurgy, nuclear track technology, thermonuclear fusion, vacuum technology, cold welding technology, biomedicine (implantology). It has become clear that information on many relevant advances, regarding ion bombardment modification of surfaces is dispersed among journals involving fields sometimes not clearly related. This may result, in some cases, in a loss of the type of interdisciplinary exchange of ideas, which has proved to be so fruitful for the advancement of science and technology. This book has been planned in an attempt to collect at least some of today's relevant information about the experimental and theoretical knowledge related to surface modification and its application to technology. (Auth.)

Proceedings of the XIII International Symposium on Biological Control of Weeds; September 11-16, 2011; Waikoloa, Hawaii, USA

Science.gov (United States)

Yun Wu; Tracy Johnson; Sharlene Sing; S. Raghu; Greg Wheeler; Paul Pratt; Keith Warner; Ted Center; John Goolsby; Richard Reardon

2013-01-01

A total of 208 participants from 78 organizations in 19 countries gathered at the Waikoloa Beach Marriott on the Big Island of Hawaii on September 11-16, 2011 for the XIII International Symposium on Biological Control of Weeds. Following a reception on the first evening, Symposium co-chairs Tracy Johnson and Pat Conant formally welcomed the attendees on the morning of...

Technologies for Hemostasis and Stabilization of the Acute Traumatic Wound

Science.gov (United States)

2012-10-01

purified fibrinogen from USARMY donated plasma. 6. Generation of purified recombinant activated Factor XIII (rFXIIIA2-a) made from yeast fermentation ...Figure 5. SDS-PAGE of purified recombinant activated Factor XIII, from fermentation of Pichia pastoris. Lane 1: molecular weight marker...fibrinogen (FI) and activated Factor XIII (FXIIIa) were generated in the milk of transgenic cows and in yeast , respectively; human r- thrombin (FIIa

Spontaneous rupture of the spleen in Factor XIII deficiency: A report of two cases

International Nuclear Information System (INIS)

Bhan, Pankaj; Al-Hilli, Shatha

2010-01-01

Spontaneous rupture of spleen due to factor XIII defieciency is a rare cause of abdominal pain with disastrous consequences and can be easily confused with other abdominal pathologies until a strong possibility is entertained.The patients usually present in emergengy with acute abdomen and diagnosis is difficult.The diagnosis is usually made on high degree of clinical suspicion and falling hematorit and failure of conservative management or by imaging. The radiologist need to be aware of this potentially fatal complication since early intervention is life saving. CT imaging can also help in conservative management in non critical patients

Kinerja Uptd dalam Pengelolaan Objek Wisata Candi Muara Takus Kecamatan XIII Koto Kampar Kabupaten Kampar

OpenAIRE

Rusli. SD, Zaili; Dewi, Marta

2016-01-01

Based on interviews and observations at the resort, there is found a phenomenon that occurs : (a) The main duties of UPTD in resort areaa of Muara Takus Tempel at XIII Koto Kampar has not been done entirely properly, (b) Many programs that have been created by UPTD inresort areas of Muara Takus Tempel was not implemented, (c) The employees in the UPTD is stiil lacking so it is affecting the main duties to be carried out properly. The aim of this study was to determine how the performance of U...

Venezuela-MEM/USA-DOE Fossil Energy Report XIII-1, Supporting Technology for Enhanced Oil Recovery, Microbial EOR; FINAL

International Nuclear Information System (INIS)

Ziritt, Jose Luis

1999-01-01

The results from Annex XIII of the Cooperative Agreement between the United States Department of Energy (DOE) and the Ministry of Energy and Mines of the Republic of Venezuela (MEMV) have been documented and published with many researchers involved. Integrate comprehensive research programs in the area of Microbial Enhanced Oil Recovery (MEOR) ranged from feasibility laboratory studies to full-scale multi-well field pilots. The objective, to cooperate in a technical exchange of ideas and information was fully met throughout the life of the Annex. Information has been exchanged between the two countries through published reports and technical meetings between experts in both country's research communities. The meetings occurred every two years in locations coincident with the International MEOR conferences and workshops sponsored by DOE (June 1990, University of Oklahoma, September 1992, Brookhaven, September 1995, National Institute of Petroleum and Energy Research). Reports and publications produced during these years are listed in Appendix B. Several Annex managers have guided the exchange through the years. They included Luis Vierma, Jose Luis Zirritt, representing MEMV and E. B. Nuckols, Edith Allison, and Rhonda Lindsey, representing the U.S. DOE. Funding for this area of research remained steady for a few years but decreased in recent years. Because both countries have reduced research programs in this area, future exchanges on this topic will occur through ANNEX XV. Informal networks established between researchers through the years should continue to function between individuals in the two countries

Il fenomeno abachistico a supporto dei cambiamenti socio-economici: Arezzo tra il XIII ed il XVI secolo = The role of the abacus tradition for the economic and social development of the society: evidence from Tuscany (Italy between XIII and XVI century

Directory of Open Access Journals (Sweden)

Maria Pia Maraghini

2011-12-01

Full Text Available Este artículo indaga sobre los orígenes de la contabilidad con el objetivo de analizar el comportamiento económico. En particular, se examinan los primeros lugares específica-mente dispuestos y organizados para la enseñanza del conocimiento contable así como los medios de estudio para su transmisión: las escuelas y los libros de ábaco. Ampliamente extendidos en Italia entre los siglos XIII y XVI tenían la finalidad de transmitir, por un lado, el conocimiento generalmente difundido como matemática práctica y, por otro, las técnicas para realizar operaciones aritméticas y las reglas prácticas para la resolución de problemas comerciales y financieros.El objetivo de esta investigación es profundizar en el estudio de las escuelas y de los libros de ábaco evidenciando el papel desempeñado en el origen de la contabilidad y en el desarrollo económico y social en la época medieval y los primeros siglos del Renacimiento.Con este fin, el estudio se basa en algunas evidencias sobre la evolución de los estudios y las escuelas de ábaco en Arezzo (Toscana, Italia entre los siglos XIII y XVI. Combinando evidencias similares con el análisis teórico el estudio revela la contribución de la tradición del ábaco en el mejor desarrollo de la vida pública en época medieval y renacentista. La constatación de esta contribución ha sido la base del creciente interés mostrado hacia la cultura del ábaco por las autoridades locales de la época.This paper focuses on the “origins” of the book-keeping art which aims to record economic behaviour. In particular, this research investigates the early specific “places” arranged and organized to teach the accounting knowledge and the primitive “means” of study with which it could be handed over: the abacus schools and books. They prevalently spread in Italy between XIII and XVI century with the aim of transferring the knowledge generally defined as “practical maths”, such as the

Gestión odontológica en los niveles de la educación básica regular en la UGEL 01 Papa León XIII - Chilca, 2015

OpenAIRE

Cornejo Serna, Manuel Elias

2016-01-01

El objetivo del presente trabajo de investigación es determinar nivel de percepción de la gestión odontológica en los niveles de la educación básica regular, en la UGEL 01, Papa León XIII - Chilca, 2015. El tipo de investigación es descriptiva y comparativa su diseño de la investigación fue de tipo no experimental de corte transversal. La población estuvo conformada por los padres de familia de la institución educativa de Papa León XIII de los niveles de educación básica reg...

Enabling Smart Grid Cosimulation Studies: Rapid Design and Development of the Technologies and Controls

Energy Technology Data Exchange (ETDEWEB)

Hansen, Timothy M.; Kadavil, Rahul; Palmintier, Bryan; Suryanarayanan, Siddharth; Maciejewski, Anthony A.; Siegel, Howard Jay; Chong, Edwin K. P.; Hale, Elaine

2016-03-01

The 21st century electric power grid is transforming with an unprecedented increase in demand and increase in new technologies. In the United States Energy Independence and Security Act of 2007, Title XIII sets the tenets for modernizing the electricity grid through what is known as the 'Smart Grid Initiative.' This initiative calls for increased design, deployment, and integration of distributed energy resources, smart technologies and appliances, and advanced storage devices. The deployment of these new technologies requires rethinking and re-engineering the traditional boundaries between different electric power system domains.

A low-cost, high-efficiency and high-flexibility surface modification technology for a black bisphenol A polycarbonate board

Energy Technology Data Exchange (ETDEWEB)

Wang, Suhuan; Liu, Jianguo, E-mail: Liujg@mail.hust.edu.cn; Lv, Ming; Zeng, Xiaoyan

2014-09-30

Highlights: • A low-cost, high-efficiency, high-flexibility surface modification technology was achieved. • Different laser modification parameters resulted in different surface microstructures. • These special microstructures played a deciding role in the surface properties. • After the modification, the surface energy was found to have a significant increase. • The technology would be advantageous to fabricate high-quality micro devices and systems. - Abstract: In this paper, a low-cost, high-efficiency and high-flexibility surface modification technology for polymer materials was achieved at high laser scanning speeds (600–1000 mm s{sup −1}) and using an all-solid state, Q-switched, high-average power, and nanosecond pulse ultraviolet (355 nm wavelength) laser. During the surface modification of a very important engineering plastic, i.e., black bisphenol A polycarbonate (BAPC) board, it was found that different laser parameters (e.g., laser fluence and pulse frequency) were able to result in different surface microstructures (e.g., many tiny protuberances or a porous microstructure with periodical V-type grooves). After the modification, although the total relative content of the oxygen-containing groups (e.g., C-O and COO{sup −}) on the BAPC surface increased, however, the special microstructures played a deciding role in the surface properties (e.g., contact angle and surface energy) of the BAPC. The change trend of the water contact angle on the BAPC surface was with an obvious increase, that of the diiodomethane contact angle was with a most decrease, and that of the ethylene glycol contact angle was between the above two. It showed that the wetting properties of the three liquids on the modified BAPC surface were different. Basing on the measurements of the contact angles of the three liquids, and according to the Young equation and the Lifshitz van der Waals and Lewis acid–base theory, the BAPC surface energy after the modification was

A low-cost, high-efficiency and high-flexibility surface modification technology for a black bisphenol A polycarbonate board

International Nuclear Information System (INIS)

Wang, Suhuan; Liu, Jianguo; Lv, Ming; Zeng, Xiaoyan

2014-01-01

Highlights: • A low-cost, high-efficiency, high-flexibility surface modification technology was achieved. • Different laser modification parameters resulted in different surface microstructures. • These special microstructures played a deciding role in the surface properties. • After the modification, the surface energy was found to have a significant increase. • The technology would be advantageous to fabricate high-quality micro devices and systems. - Abstract: In this paper, a low-cost, high-efficiency and high-flexibility surface modification technology for polymer materials was achieved at high laser scanning speeds (600–1000 mm s −1 ) and using an all-solid state, Q-switched, high-average power, and nanosecond pulse ultraviolet (355 nm wavelength) laser. During the surface modification of a very important engineering plastic, i.e., black bisphenol A polycarbonate (BAPC) board, it was found that different laser parameters (e.g., laser fluence and pulse frequency) were able to result in different surface microstructures (e.g., many tiny protuberances or a porous microstructure with periodical V-type grooves). After the modification, although the total relative content of the oxygen-containing groups (e.g., C-O and COO − ) on the BAPC surface increased, however, the special microstructures played a deciding role in the surface properties (e.g., contact angle and surface energy) of the BAPC. The change trend of the water contact angle on the BAPC surface was with an obvious increase, that of the diiodomethane contact angle was with a most decrease, and that of the ethylene glycol contact angle was between the above two. It showed that the wetting properties of the three liquids on the modified BAPC surface were different. Basing on the measurements of the contact angles of the three liquids, and according to the Young equation and the Lifshitz van der Waals and Lewis acid–base theory, the BAPC surface energy after the modification was calculated

Repletion of factor XIII following cardiopulmonary bypass using a recombinant A-subunit homodimer. A preliminary report

DEFF Research Database (Denmark)

Levy, Jerrold H; Gill, Ravi; Nussmeier, Nancy A

2009-01-01

Bleeding following cardiac surgery involving cardiopulmonary bypass (CPB) remains a major concern. Coagulation factor XIII (FXIII) functions as a clot-stabilising factor by cross-linking fibrin. Low post-operative levels of FXIII correlate with increased post-operative blood loss. To evaluate...... preliminary safety and pharmacokinetics of recombinant FXIII (rFXIII-A(2)) in cardiac surgery, patients scheduled for coronary artery bypass grafting were randomised to receive a single dose of either rFXIII-A(2) (11.9, 25, 35 or 50 IU/kg) or placebo in a 4:1 ratio. Study drug was given post-CPB within 10...

El consulado genovés de Sevilla (siglos XIII-XV. Aspectos jurisdiccionales, comerciales y fiscales

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José Damián GONZÁLEZ ARCE

2011-02-01

Full Text Available El presente artículo analiza el funcionamiento del consulado genovés de Sevilla, entre los siglos XIII y XV, a partir de los privilegios concedidos por los reyes castellanos y otros documentos donde se contienen noticias sobre la actividad de estos italianos. En primer lugar, se estudian las competencias jurisdiccionales de dicho consulado y las facultades judiciales de sus cónsules. Luego son descritas las actividades mercantiles de la colonia ligur en el marco del consulado, así como otros aspectos ligados al comercio, como seguros y transportes. Y, finalmente, las exacciones fiscales a las que fueron sometidas esta colonia y las mercancías con las que traficó.

EVALUASI PENGENDALIAN INTERNAL TERHADAP PENERIMAAN DAN PENGELUARAN KAS PADA PT PLN (PerseroUNIT INDUK PEMBANGUNAN XIII MAKASSAR

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ESTER DEWI

2017-05-01

There is also the purpose of writing is: 1 .To analyze the structure of the organization, 2. Analyze the system mechanisms and procedures for cash receipts and expenditure, 3 Analyze healthy practice associated with research at PT PLN (Persero Parent Unit XIII development Makassar. The purpose of writing, 4. Analyzing the quality and reliability of employees in his work responsibility. The methodology used is the research field research and questionnaires while the analysis used was a descriptive comparative analysis aims to describe the activities of the company, especially in the Internal Control System Cash Receipts and Expenditure.

Of decentralization of public power Ukrainian land that belonged to Lithuanian (XIII – the early XVII century

Directory of Open Access Journals (Sweden)

C. V. Manuilova

2016-06-01

Full Text Available A comprehensive crisis in Ukraine and continued military confrontation in the Donbass demonstrated the urgent need to establish effective governance, which would imply decentralization of public power. Note that in implementing the decentralization of power in Ukraine insists the International Monetary Fund; United Nations Development Program; the transfer of authority to the field and decentralization of power in Ukraine is one of the points of the Minsk agreements and obligations of Ukraine to the EU. The article deals with the Ukrainian lands topical issue features the decentralization of public power in the XIII - the beginning of XVII century. The importance of the topic due to the need to study the historical experience of the implementation of decentralization. It was, emphasized that the success of the reforms depends largely because of the historical experience and features of the decentralization of public power in the past. Characterized by the development of local government in the Ukrainian lands was part of the Lithuanian state. The purpose of the article is to clarify the characteristics of decentralization of public authority on Ukrainian lands were part of the Lithuanian state during the XVII century XIII. To address this goal, outline decentralization of public power in the state; analyze, competence of local government in the Ukrainian lands that belonged to the Lith uanian State; determine how close to the power of the people. The level of decentralization of public power in the Grand Duchy of Lithuania in the XIII - the beginning of XVII century was high. It was, found that Lithuania had not established a centralized state. It is, noted that the Board of the nobility limited the princely power. The effect of delegated deputies from different parts of the Lithuanian statehood solutions nobility Council.Clarified the facts that confirm the existence of decentralization of public power in Lithuania: the functioning of local

PIXE and IL analysis of an archeologically problematic XIII century ceramic production

Energy Technology Data Exchange (ETDEWEB)

Zucchiatti, Alessandro, E-mail: alessandro.zucchiatti@uam.es [Centro de Micro-Análisis de Materiales, Universidad Autónoma de Madrid, C/Faraday 3, Madrid (Spain); Jiménez-Rey, David [Centro de Micro-Análisis de Materiales, Universidad Autónoma de Madrid, C/Faraday 3, Madrid (Spain); Laboratorio Nacional de Fusión CIEMAT, E06.P2.09, Madrid (Spain); Climent-Font, Aurelio [Centro de Micro-Análisis de Materiales, Universidad Autónoma de Madrid, C/Faraday 3, Madrid (Spain); Departamento di Física Aplicada, Universidad Autónoma de Madrid, Madrid (Spain); Martina, Silvia [Centro de Micro-Análisis de Materiales, Universidad Autónoma de Madrid, C/Faraday 3, Madrid (Spain); Universitá degli Studi di Torino, Turin (Italy); Faieta, Rosangela [Centro de Micro-Análisis de Materiales, Universidad Autónoma de Madrid, C/Faraday 3, Madrid (Spain); Universitá della Tuscia, Viterbo (Italy); Maggi, Marco [Musei Vaticani, Ufficio del Conservatore, Rome (Italy); Giuntini, Lorenzo; Calusi, Silvia [INFN – Laboratorio di tecniche Nucleari per i Beni Culturali, Florence (Italy)

2015-11-15

At the beginning of the XIII century the archaeologists have found evidence of a singular, transitional, pottery technique limited to a small area around western Liguria (Northwest of Italy). Known as Ligurian Protomajolica (PML), it shows in the same ceramic body and on the same surface white slip and enamel together, addressing questions about the technical reasons of this unusual combination, its origin and evolution. To integrate previous morphological and mineralogical studies, we have analysed by particle induced X-ray emission (also with mapping) and ionoluminescence (IL) the ceramic body, slip and glaze composition of 56 samples, of which 25 PML’s. We have identified some PML’s compositional features which are distinct from those of other coeval or later productions from the same area. A few PML imitations are described. A plausible explanation of the origin of the PML’s, based both on the archaeometric results and the archaeological and historical knowledge, is presented.

MODIFICATION OF PAPERMAKING GRADE FILLERS: A BRIEF REVIEW

Directory of Open Access Journals (Sweden)

Jing Shen

2009-08-01

Full Text Available The use of fillers in paper products can provide cost and energy savings, improved paper properties, increased productivities, and specifically desired paper functionalities. There are many problems associated with the use of fillers, such as unsuitability of calcium carbonate fillers in acid papermaking, negative effects of filler loading on paper strength, sizing, and retention, and tendencies of fillers to cause abrasion and dusting. In order to solve these problems and to make better use of fillers, many methods have been proposed, among which filler modification has been a hot topic. The available technologies of filler modification mainly include modification with inorganic substances, modification with natural polymers or their derivatives, modification with water-soluble synthetic polymers, modification with surfactants, modification with polymer latexes, hydrophobic modification, cationic modification, surface nano-structuring, physical modification by compressing, calcination or grinding, and modification for use in functional papers. The methods of filler modification can provide improved acid tolerant and optical properties of fillers, enhanced fiber-filler bonding, improved filler retention and filler sizabilities, alleviated filler abrasiveness, improved filler dispersability, and functionalization of filled papers. Filler modification has been an indispensable way to accelerate the development of high filler technology in papermaking, which is likely to create additional benefits to papermaking industry in the future.

Acquired Factor Xiii Deficiency: An Uncommon But Easily Missed Cause Of Severe Bleeding

LENUS (Irish Health Repository)

Fogarty, H

2018-05-01

Factor XIII (FXIII) is a plasma clotting protein involved in clot stabilization. Severe FXIII deficiency may present with severe, even fatal bleeding. Critically however, routine coagulation assays may be normal and only specific FXIII assays will detect the abnormality. Herein we discuss a case report of a patient with acquired FXIII deficiency in order to highlight the clinical challenges associated with establishing the diagnosis and discuss the treatment approach. A 70-year-old man presented with a gluteal haematoma despite no preceding personal history of bleeding. Extensive initial haemostatic investigations were normal until a specific FXIII assay showed a marked reduction in FXIII levels. With directed treatment, bleeding episodes ceased and remission was achieved. Clinical awareness of FXIII deficiency is important, so appropriate testing can be implemented in patients with unexplained bleeding diatheses, particularly those in whom bleeding responds poorly to standard replacement therapy.

Accommodating for plant modifications

International Nuclear Information System (INIS)

Weirich, P.H.

1977-01-01

Modification to a nuclear power plant may have different causes: 1) new instructions by the authorities; 2) changes of the marginal conditions on the construction site; 3) progress in the technological development. - Examples from different plants are supposed to demonstrate how such changes influence the planning or the construction and how they are integrated in the process of preparation. A distinction can be made between modifications before the completion of the submission of the order, during the phase of preparatory planning and during the construction phase. Of great importance are especially modifications made after the beginning of the construction works, since, in general, there is little scope for technical modifications and since consequences for the time schedule are to be expected. (orig.) [de

La expansión del posesivo pospuesto a la luz de documentación navarra (y aragonesa) del siglo XIII

OpenAIRE

Romero Cambrón, Angeles

2016-01-01

En los primitivos documentos romances el posesivo sólo aparece antepuesto al sustantivo (“(el) nuestro padre”). La posposición (“padre nuestro”) se empieza a registrar en el siglo XIII en aragonés y en dialecto navarro. Considerando principalmente la documentación de esta segunda variedad, el presente trabajo tiene como objetivo determinar el modo en que el posesivo adquirió la capacidad de aparecer pospuesto. Este cambio se vio impulsado por factores de naturaleza estructural. Uno de ellos e...

Clot retraction is mediated by factor XIII-dependent fibrin-αIIbβ3-myosin axis in platelet sphingomyelin-rich membrane rafts.

Science.gov (United States)

Kasahara, Kohji; Kaneda, Mizuho; Miki, Toshiaki; Iida, Kazuko; Sekino-Suzuki, Naoko; Kawashima, Ikuo; Suzuki, Hidenori; Shimonaka, Motoyuki; Arai, Morio; Ohno-Iwashita, Yoshiko; Kojima, Soichi; Abe, Mitsuhiro; Kobayashi, Toshihide; Okazaki, Toshiro; Souri, Masayoshi; Ichinose, Akitada; Yamamoto, Naomasa

2013-11-07

Membrane rafts are spatially and functionally heterogenous in the cell membrane. We observed that lysenin-positive sphingomyelin (SM)-rich rafts are identified histochemically in the central region of adhered platelets where fibrin and myosin are colocalized on activation by thrombin. The clot retraction of SM-depleted platelets from SM synthase knockout mouse was delayed significantly, suggesting that platelet SM-rich rafts are involved in clot retraction. We found that fibrin converted by thrombin translocated immediately in platelet detergent-resistant membrane (DRM) rafts but that from Glanzmann's thrombasthenic platelets failed. The fibrinogen γ-chain C-terminal (residues 144-411) fusion protein translocated to platelet DRM rafts on thrombin activation, but its mutant that was replaced by A398A399 at factor XIII crosslinking sites (Q398Q399) was inhibited. Furthermore, fibrin translocation to DRM rafts was impaired in factor XIII A subunit-deficient mouse platelets, which show impaired clot retraction. In the cytoplasm, myosin translocated concomitantly with fibrin translocation into the DRM raft of thrombin-stimulated platelets. Furthermore, the disruption of SM-rich rafts by methyl-β-cyclodextrin impaired myosin activation and clot retraction. Thus, we propose that clot retraction takes place in SM-rich rafts where a fibrin-αIIbβ3-myosin complex is formed as a primary axis to promote platelet contraction.

Application of plasma technology for the modification of polymer and textile materials

Directory of Open Access Journals (Sweden)

Radetić Maja M.

2004-01-01

Full Text Available Plasma treatment is based on the physico-chemical changes of the material surface and as an ecologically and economically acceptable process it can be an attractive alternative to conventional modifications. The possibilities of plasma technology application to the modification of polymer and textile materials are discussed. Different specific properties of the material can be achieved by plasma cleaning, etching, functionalization or polymerization. The final effects are strongly influenced by the treatment parameters (treatment time, pressure, power, gas flow, the applied gas and nature of the material. The plasma treatment of polymers is predominantly focused on cleaning and activation of the surfaces to increase adhesion, binding, wettability, dye ability and printability. Current studies deal more with plasma polymerization where an ultra thin film of plasma polymer is deposited on the material surface and, depending on the applied monomer, different specific properties can be obtained (i.e. chemical and thermal resistance, abrasion resistance, antireflexion, water repellence, etc.. Plasma application to textiles is mostly oriented toward wool and synthetic fibres, though some studies also consider cotton, hemp, flax and silk. The main goal of plasma treatment is to impart a more hydrophilic fibre surface and accordingly increase wettability, dye ability, printability and particularly, shrink resistance in the case of wool. Recent studies have favored technical textiles, where plasma polymerization can offer a wide range of opportunities.

Del "scriptor" al "publicus notarius" : los escribanos de Madrid en el siglo XIII

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María Teresa Carrasco Lazareno

2003-01-01

Full Text Available Estudio diplomático y jurídicoinstitucional de las escribanías de Madrid en el siglo XIII. Se analiza su evolución desde los primeros "Scriptores» prenotariales conocidos, clérigos y laicos de libre profesión, documentados hasta 1260, hasta la consolidación definitiva de la institución notarial y del instrumento público en el último cuarto del siglo XIII. Se estudian con detenimiento la compleja etapa de transición, en las décadas centrales de la centuria, la figura del «escrivano de congejo de Madrit», profesional estable y antecedente inmediato del escribano público, y la instauración del notariado, de acuerdo con la legislación alfonsina, así como de la escribanía municipal, por otorgamiento de Alfonso X, en 1264. A través de la documentación conservada, se analiza, asimismo, la transformación de la simple carta o «scriptura» testifical en «publicum instrumentum», mediante la valoración de la pervivencia de elementos tradicionales y la aparición de fórmulas diplomáticas que revelan la paulatina introducción.This is a diplomatic and a legal — institutional study about the actuarles offices in Madrid during the Xlllth century Its evolution is analyzed from the first known prenotarial "scriptores», priests and liberal professionals seculars, documented until 1260, until the final consolidation of the notary institution and the public instrument during the last quarter of the Xlllth century There is a detailed study about the complexity of the transitional period, during the central decades of that century, the figure of the «Notary of the Madrid Town Council», as a stable professional and immediate predecessor of the public actuary the establishment of the body of actuarles, according to the Alphonsine legislation, an the municipal actuary office, established by King Alphonse Xth., in 1264. Through the preserved documentation, it is analized, at the same time, the transformation of the simple letter, or

Recent Advances in Attention Bias Modification for Substance Addictions

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Melvyn Weibin Zhang

2018-04-01

Full Text Available Research on attentional bias modification has increased since 2014. A recent meta-analysis demonstrates evidence for bias modification for substance disorders, including alcohol and tobacco use disorders. Several pharmacological trials have shown that pharmacological agents can attenuate and modify such attentional bias. The pharmacological trials that have appeared to date have produced mixed results, which has clinical implications. Developments in Internet and mobile technologies have transformed how attention bias modification is currently being achieved. There remains great potential for further research that examines the efficacy of technology-aided attention bias interventions.

La formazione di un’aristocrazia: monache e monasteri femminili a Venezia tra IX e XIII secolo

Directory of Open Access Journals (Sweden)

Rapetti, Anna

2014-06-01

Full Text Available This paper examines the processes that shaped the identity of the Venetian aristocracy from the 9th to the 13th centuries and the role played by the relationship between patrician families and some female monasteries. The important female monastery of San Zaccaria and some other nunneries created in the lagoon between the 12th and the 13th centuries are taken into account in the analysis of the formation of Venetian aristocracy from this innovative perspective. By analysing the behaviour of the aristocratic families towards these nunneries, the paper points out how Venetian ruling groups made use of the long-term relationship with nuns as a particularly useful instrument of political competition. The article also shows how some female monasteries were relevant social actors in the process of defi nition of Venetian identity, largely coinciding with their own ruling groups, and in particular with the aristocracy, and with the exercise of power.[it] L’articolo si propone di esaminare il processo di definizione dell’identità del ceto dirigente di Venezia nel periodo IX-XIII secolo e il ruolo occupato dalle relazioni tra le famiglie dell’aristocrazia che costituivano quel ceto e alcuni monasteri femminili. In questa prospettiva, innovativa nell’analisi della formazione dell’aristocrazia di Venezia, si prenderà in esame l’importante monastero femminile di San Zaccaria e si farà inoltre riferimento ad alcuni altri, sorti sulle isole della laguna tra XII e XIII secolo, espressione di un clima religioso e sociale nuovo e particolare. Attraverso l’analisi dei comportamenti adottati dalle famiglie aristocratiche nei confronti di questi monasteri, si dimostra che il ceto dirigente veneziano si servì delle relazioni costanti con le monache come di uno strumento della lotta politica particolarmente utilizzato dalle famiglie dell’aristocrazia della città. Si osserva anche che alcuni monasteri femminili furono a loro volta soggetti attivi

Energy Levels and Radiative Rates for Transitions in F-like Sc XIII and Ne-like Sc XII and Y XXX

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Kanti M. Aggarwal

2018-05-01

Full Text Available Energy levels, radiative rates and lifetimes are reported for F-like Sc XIII and Ne-like Sc XII and Y XXX for which the general-purpose relativistic atomic structure package (GRASP has been adopted. For all three ions, limited data exist in the literature but comparisons have been made wherever possible to assess the accuracy of the calculations. In the present work, the lowest 102, 125 and 139 levels have been considered for the respective ions. Additionally, calculations have also been performed with the flexible atomic code (FAC to (particularly confirm the accuracy of energy levels.

Energy Levels and Radiative Rates for Transitions in F-like Sc XIII and Ne-like Sc XII and Y XXX

Science.gov (United States)

Aggarwal, Kanti

2018-05-01

Energy levels, radiative rates and lifetimes are reported for F-like Sc~XIII and Ne-like Sc~XII and Y~XXX for which the general-purpose relativistic atomic structure package ({\\sc grasp}) has been adopted. For all three ions limited data exist in the literature but comparisons have been made wherever possible to assess the accuracy of the calculations. In the present work the lowest 102, 125 and 139 levels have been considered for the respective ions. Additionally, calculations have also been performed with the flexible atomic code ({\\sc fac}) to (particularly) confirm the accuracy of energy levels.

Radiation protection in the 2000s - Theory and practice. Nordic Society for Radiation Protection. Proceedings of the XIII ordinary meeting

International Nuclear Information System (INIS)

Paile, W.

2003-06-01

The XIII ordinary meeting of the Nordic Society for Radiation Protection (NSFS) was held on August 25-29, 2002 in Turku (Aabo), Finland. The main topics included: protection of the environment, information and ethics, natural radiation, reactor safety and waste management, emergency preparedness, medical use of radiation, radiation in industrial use, education and certification, radiation biology and epidemiology, and radioecology and monitoring. The proceedings of the meeting includes all the papers of the oral presentations as well as the poster presentations. Papers presenting scientific results have been subject to a referee process with evaluation of independent experts

The ethics of molecular memory modification.

Science.gov (United States)

Hui, Katrina; Fisher, Carl E

2015-07-01

Novel molecular interventions have recently shown the potential to erase, enhance and alter specific long-term memories. Unique features of this form of memory modification call for a close examination of its possible applications. While there have been discussions of the ethics of memory modification in the literature, molecular memory modification (MMM) can provide special insights. Previously raised ethical concerns regarding memory enhancement, such as safety issues, the 'duty to remember', selfhood and personal identity, require re-evaluation in light of MMM. As a technology that exploits the brain's updating processes, MMM helps correct the common misconception that memory is a static entity by demonstrating how memory is plastic and subject to revision even in the absence of external manipulation. Furthermore, while putatively safer than other speculative technologies because of its high specificity, MMM raises notable safety issues, including potential insidious effects on the agent's emotions and personal identity. Nonetheless, MMM possesses characteristics of a more permissible form of modification, not only because it is theoretically safer, but because its unique mechanism of action requires a heightened level of cooperation from the agent. Discussions of memory modification must consider the specific mechanisms of action, which can alter the weight and relevance of various ethical concerns. MMM also highlights the need for conceptual accuracy regarding the term 'enhancement'; this umbrella term will have to be differentiated as new technologies are applied to a widening array of purposes. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Investigation of surface halide modification of nitrile butadiene rubber

Science.gov (United States)

Sukhareva, K. V.; Mikhailov, I. A.; Andriasyan, Yu O.; Mastalygina, E. E.; Popov, A. A.

2017-12-01

The investigation is devoted to the novel technology of surface halide modification of rubber samples based on nitrile butadiene rubber (NBR). 1,1,2-trifluoro-1,2,2-trichlorethane was used as halide modifier. The developed technology is characterized by production stages reduction to one by means of treating the rubber compound with a halide modifier. The surface halide modification of compounds based on nitrile butadiene rubber (NBR) was determined to result in increase of resistance to thermal oxidation and aggressive media. The conducted research revealed the influence of modification time on chemical resistance and physical-mechanical properties of rubbers under investigation.

Averroes en la revolución intelectual del siglo XIII: bases para una reinterpretación de la Modernidad

OpenAIRE

Herráiz Oliva, Pilar

2016-01-01

El objetivo de esta tesis es mostrar cómo, en el siglo XIII, en la facultad de artes de la Universidad de París, el averroísmo, o el aristotelismo radical, emergió como movimiento filosófico que defendía la autonomía de la razón, de la filosofía y de la ciencia. Otro de los objetivos de esta tesis es mostrar que la secularización y la especialización de las distintas ciencias, tal y como las concebimos hoy, tienen su origen en la nueva forma de hacer filosofía que surge de las exigencias meto...

Modification-specific proteomics: strategies for characterization of post-translational modifications using enrichment techniques

DEFF Research Database (Denmark)

Zhao, Yingming; Jensen, Ole N

2009-01-01

More than 300 different types of protein post-translational modifications (PTMs) have been described, many of which are known to have pivotal roles in cellular physiology and disease. Nevertheless, only a handful of PTMs have been extensively investigated at the proteome level. Knowledge of protein...... substrates and their PTM sites is key to dissection of PTM-mediated cellular processes. The past several years have seen a tremendous progress in developing MS-based proteomics technologies for global PTM analysis, including numerous studies of yeast and other microbes. Modification-specific enrichment...

Modification of Material Surface Using Plasma-Enhanced Ion Beams

National Research Council Canada - National Science Library

Bystritskii, V

1998-01-01

...) Technology for Materials Surface Modification. Following second year programmatic plan, formulated in the conclusion of the 1-st year report we focused our effort on study of aluminum alloys modification (Al2024, 6061, 7075...

EDITORIAL: XIII Mexican Workshop on Particles and Fields

Science.gov (United States)

Barranco, Juan; Contreras, Guillermo; Delepine, David; Napsuciale, Mauro

2012-08-01

Juan Barranco Physics Department, Guanajuato University, Loma del Bosque 103, col. Loma del Campestre, 37150, Leon (Mexico) jbarranc@fisica.ugto.mx Guillermo Contreras Departamento de Fisica Aplicada Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Merida (Mexico) jgcn@mda.cinvestav.mx David Delepine Physics Department, Guanajuato University, Loma del Bosque 103, col. Loma del Campestre, 37150, Leon (Mexico) delepine@fisica.ugto.mx Mauro Napsuciale Physics Department, Guanajuato University, Loma del Bosque 103, col. Loma del Campestre, 37150, Leon (Mexico) mauro@fisica.ugto.mx The XIII Mexican Workshop on Particles and Fields (MWPF) took place from 20-26 October 2011, in the city of León, Guanajuato, México. This is a biennial meeting organized by the Division of Particles and Fields of the Mexican Physical Society designed to gather specialists in different areas of high energy physics to discuss the latest developments in the field. The thirteenth edition of this meeting was hosted by the Department of Cultural Studies of Guanajuato University in a nice environment dedicated to the Arts and Culture. The XIII MWPF was organized by three working groups who organized the corresponding sessions around three topics. The first one was Strings, Cosmology, Astroparticles and Physics Beyond the Standard Model. In this category we included: Cosmic Rays, Gamma Ray Bursts, Physics Beyond the Standard Model (theory and experimental searches), Strings and Cosmology. The working group for this topic was formed by Arnulfo Zepeda, Oscar Loaiza, Axel de la Macorra and Myriam Mondragón. The second topic was Hadronic Matter which included Perturbative QCD, Jets and Diffractive Physics, Hadronic Structure, Soft QCD, Hadron Spectroscopy, Heavy Ion Collisions and Soft Physics at Hadron Colliders, Lattice Results and Instrumentation. The working group for this topic was integrated by Wolfgang Bietenholz and Mariana Kirchbach. The third topic was

Extreme Ultraviolet Emission Lines of Iron Fe XI-XIII

Science.gov (United States)

Lepson, Jaan; Beiersdorfer, P.; Brown, G. V.; Liedahl, D. A.; Brickhouse, N. S.; Dupree, A. K.

2013-04-01

The extreme ultraviolet (EUV) spectral region (ca. 20--300 Å) is rich in emission lines from low- to mid-Z ions, particularly from the middle charge states of iron. Many of these emission lines are important diagnostics for astrophysical plasmas, providing information on properties such as elemental abundance, temperature, density, and even magnetic field strength. In recent years, strides have been made to understand the complexity of the atomic levels of the ions that emit the lines that contribute to the richness of the EUV region. Laboratory measurements have been made to verify and benchmark the lines. Here, we present laboratory measurements of Fe XI, Fe XII, and Fe XIII between 40-140 Å. The measurements were made at the Lawrence Livermore electron beam ion trap (EBIT) facility, which has been optimized for laboratory astrophysics, and which allows us to select specific charge states of iron to help line identification. We also present new calculations by the Hebrew University - Lawrence Livermore Atomic Code (HULLAC), which we also utilized for line identification. We found that HULLAC does a creditable job of reproducing the forest of lines we observed in the EBIT spectra, although line positions are in need of adjustment, and line intensities often differed from those observed. We identify or confirm a number of new lines for these charge states. This work was supported by the NASA Solar and Heliospheric Program under Contract NNH10AN31I and the DOE General Plasma Science program. Work was performed in part under the auspices of the Department of Energy by Lawrence Livermore National Laboratory under Contract DEAC52-07NA27344.

I Thought This Was a Study on Math Games: Attribute Modification in Children’s Interactions with Mathematics Apps

Directory of Open Access Journals (Sweden)

Stephen I Tucker

2017-05-01

Full Text Available Technology is an increasingly important component of education. Children’s mathematical interactions with technology have become a focus of mathematics education research, but less research has investigated constructs that contribute to these mathematical interactions. Attributes of children and technology play a key role in mathematical interactions and both children and technology can modify attributes during these interactions. Grounded in the Artifact-Centric Activity Theory and linked to recent developments in research on technology in mathematics education, this qualitative study extended an earlier exploratory study to investigate attribute modification. In particular, this study examined patterns of attribute modification evident during fifth grade students’ mathematical interactions with two mathematics virtual manipulative touchscreen tablet apps. Results included three categories related to attribute modification: (1 reactive attribute modification (linear progression or repeated repetition; (2 unperceived attributes and opportunities for proactive modification; and (3 proactive modification (seeking equilibrium, seeking disequilibrium, or seeking equilibrium and disequilibrium. Findings have implications for designers, teachers, and researchers of educational technology.

Electron beam processing technology for modification of different types of cellulose pulps for production of derivatives

International Nuclear Information System (INIS)

Iller, E.; Kukielka, A.; Mikolajczyk, W.; Starostka, P.; Stupinska, H.

2002-01-01

Institute of Nuclear Chemistry and Technology, Pulp and Paper Research Institute and Institute of Chemical Fibers carry out a joint research project in order to develop the radiation methods modification of cellulose pulps for production of cellulose derivatives such as carbamate (CC), carboxymethyl cellulose (CMC) and methylcellulose (MC). Three different types of textile pulps: Alicell (A); Borregaard (B), Ketchikan (K) and Kraft softwood (PSS) and hardwood (PSB) pulps have been irradiated with 10 MeV electron beam from LAE 13/9 linear accelerator with doses of 5, 10, 15, 20, 25 and 50 kGy. After electron beam treatment the samples of cellulose pulps have been examined by using of structural and physico-chemical methods. Electron paramagnetic resonance spectroscopy (EPR), gel permeation chromatography (GPC) and infrared spectroscopy (IRS) were applied for determination of structural changes in irradiated cellulose pulps. By means of analytical methods, such parameters as: viscosity, average degree of polymerization (DP) and α-cellulose contents were evaluated. Based on EPR and GPC investigations the relationship between concentrations of free radicals and decreasing polymerization degrees in electron beam treatment pulps has been confirmed. The carboxymethylcellulose, methylcellulose and cellulose carbamate were prepared using the raw material of radiation modified pulps. Positive results of investigations will allow for determination of optimum conditions for electron beam modification of selected cellulose paper and textile pulps. Such procedure leads to limit the amounts of chemical activators used in methods for preparation cellulose derivatives. The proposed electron beam technology is new approaches in technical solution and economic of process of cellulose derivatives preparation. (author)

Surface modification of bisphenol A polycarbonate material by ultraviolet Nd:YVO4 laser high-speed microprocessing technology

International Nuclear Information System (INIS)

Liu, Jianguo; Wang, Suhuan; Lv, Ming; Zeng, Xiaoyan

2014-01-01

In this paper, a low-cost and high-efficiency microprocessing modification technology for the surface of bisphenol A polycarbonate (BAPC) material was achieved (in particular, from hydrophilicity to hydrophobicity) at high laser scanning speeds (600–1000 mm s  − 1 ) and using an all-solid state, Q-switched, high-average power and nanosecond pulse Nd:YVO 4 laser (355 nm wavelength). During the modification, it was found that the laser fluence and pulse width were the two main parameters affecting the modification effect. Moreover, the modification had a significant effect on the water contact angle, wetting behavior, microstructure, average roughness and chemical composition of the surface. When the laser fluences applied were low (i.e., less than the so-called critical fluence of the UV laser modification of the BAPC material), the water contact angle was found to be a little less than the original, the hydrophilicity was slightly improved, the relative content of the oxygen-containing groups (e.g. O–C and COO  −  ) increased, the microstructure and average roughness only had a very slight change, and the wetting behavior complied with the Wenzel regime. On the other hand, when the laser fluences applied were high, the water contact angle significantly increased, the hydrophilicity markedly decreased and the relative content of the oxygen-containing groups also increased. Here, a porous microstructure with periodical v-type grooves was generated and the average roughness had an obvious increase. In this case, the wetting behavior could be explained by the Cassie-Baxter regime, i.e., the microstructure and average roughness change played a deciding role. The reason for this might be that different laser parameters result in different material deformation and removal processes, thereby resulting in different surface chemical compositions, microstructures, roughnesses and wetting properties. (paper)

Experience with digital instrumentation and control systems for CANDU power plant modifications

International Nuclear Information System (INIS)

Basu, S.

1997-01-01

Over the last years, Ontario Hydro CANDU power plants have gone through many modifications. This includes modification from analog hardwired controls to digital and solid state controls and replacement of the existing digital controls with the latest hardware and software technology. Examples of digital modifications at Bruce A and other CANDU power plants are briefly described and categorized. Most of the I and C technology development has been supported by the CANDU Owners Group (COG) a consortium of Canadian nuclear utilities and the Atomic Energy Canada Limited (AECL). (author)

Experience with digital instrumentation and control systems for CANDU power plant modifications

Energy Technology Data Exchange (ETDEWEB)

Basu, S [Ontario Hydro, Toronto, ON (Canada)

1997-07-01

Over the last years, Ontario Hydro CANDU power plants have gone through many modifications. This includes modification from analog hardwired controls to digital and solid state controls and replacement of the existing digital controls with the latest hardware and software technology. Examples of digital modifications at Bruce A and other CANDU power plants are briefly described and categorized. Most of the I and C technology development has been supported by the CANDU Owners Group (COG) a consortium of Canadian nuclear utilities and the Atomic Energy Canada Limited (AECL). (author).

Induced mutation and epigenetics modification in plants for crop improvement by targeting CRISPR/Cas9 technology.

Science.gov (United States)

Khan, Muhammad Hafeez Ullah; Khan, Shahid U; Muhammad, Ali; Hu, Limin; Yang, Yang; Fan, Chuchuan

2018-06-01

Clustered regularly interspaced palindromic repeats associated protein Cas9 (CRISPR-Cas9), originally an adaptive immunity system of prokaryotes, is revolutionizing genome editing technologies with minimal off-targets in the present era. The CRISPR/Cas9 is now highly emergent, advanced, and highly specific tool for genome engineering. The technology is widely used to animal and plant genomes to achieve desirable results. The present review will encompass how CRISPR-Cas9 is revealing its beneficial role in characterizing plant genetic functions, genomic rearrangement, how it advances the site-specific mutagenesis, and epigenetics modification in plants to improve the yield of field crops with minimal side-effects. The possible pitfalls of using and designing CRISPR-Cas9 for plant genome editing are also discussed for its more appropriate applications in plant biology. Therefore, CRISPR/Cas9 system has multiple benefits that mostly scientists select for genome editing in several biological systems. © 2017 Wiley Periodicals, Inc.

Plasma-Assisted Synthesis and Surface Modification of Electrode Materials for Renewable Energy.

Science.gov (United States)

Dou, Shuo; Tao, Li; Wang, Ruilun; El Hankari, Samir; Chen, Ru; Wang, Shuangyin

2018-02-14

Renewable energy technology has been considered as a "MUST" option to lower the use of fossil fuels for industry and daily life. Designing critical and sophisticated materials is of great importance in order to realize high-performance energy technology. Typically, efficient synthesis and soft surface modification of nanomaterials are important for energy technology. Therefore, there are increasing demands on the rational design of efficient electrocatalysts or electrode materials, which are the key for scalable and practical electrochemical energy devices. Nevertheless, the development of versatile and cheap strategies is one of the main challenges to achieve the aforementioned goals. Accordingly, plasma technology has recently appeared as an extremely promising alternative for the synthesis and surface modification of nanomaterials for electrochemical devices. Here, the recent progress on the development of nonthermal plasma technology is highlighted for the synthesis and surface modification of advanced electrode materials for renewable energy technology including electrocatalysts for fuel cells, water splitting, metal-air batteries, and electrode materials for batteries and supercapacitors, etc. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Scientific session NRNU MEPHI-2010. XIII International Telecommunication Conference of students and young scientists Young people and science. Book of abstracts. In three parts. Part 1

International Nuclear Information System (INIS)

2010-01-01

In the collection of works there are the abstracts of reports included in the program of XIII International Telecommunication Conference of students and young scientists Young people and science which took place in the Internet in November-December, 2009 on the NRNU MEPhI site http://www.molod.mephi.ru/. The topics of the conference cover a wide range of problems: applied physics and energetics, ecology, development of new materials, medical physics, nanotechnologies, automatics and electronics, information-telecommunication systems and others [ru

Biomimetic surface modification of polypropylene by surface chain transfer reaction based on mussel-inspired adhesion technology and thiol chemistry

Energy Technology Data Exchange (ETDEWEB)

Niu, Zhijun; Zhao, Yang; Sun, Wei; Shi, Suqing, E-mail: shisq@nwu.edu.cn; Gong, Yongkuan

2016-11-15

Highlights: • Biomimetic surface modification of PP was successfully conducted by integrating mussel-inspired technology, thiol chemistry and cell outer membranes-like structures. • The resultant biomimetic surface exhibits good interface and surface stability. • The obvious suppression of protein adsorption and platelet adhesion is also achieved. • The residue thoil groups on the surface could be further functionalized. - Abstract: Biomimetic surface modification of polypropylene (PP) is conducted by surface chain transfer reaction based on the mussel-inspired versatile adhesion technology and thiol chemistry, using 2-methacryloyloxyethylphosphorylcholine (MPC) as a hydrophilic monomer mimicking the cell outer membrane structure and 2,2-azobisisobutyronitrile (AIBN) as initiator in ethanol. A layer of polydopamine (PDA) is firstly deposited onto PP surface, which not only offers good interfacial adhesion with PP, but also supplies secondary reaction sites (-NH{sub 2}) to covalently anchor thiol groups onto PP surface. Then the radical chain transfer to surface-bonded thiol groups and surface re-initiated polymerization of MPC lead to the formation of a thin layer of polymer brush (PMPC) with cell outer membrane mimetic structure on PP surface. X-ray photoelectron spectrophotometer (XPS), atomic force microscopy (AFM) and water contact angle measurements are used to characterize the PP surfaces before and after modification. The protein adsorption and platelet adhesion experiments are also employed to evaluate the interactions of PP surface with biomolecules. The results show that PMPC is successfully grafted onto PP surface. In comparison with bare PP, the resultant PP-PMPC surface exhibits greatly improved protein and platelet resistance performance, which is the contribution of both increased surface hydrophilicity and zwitterionic structure. More importantly, the residue thiol groups on PP-PMPC surface create a new pathway to further functionalize such

Biomimetic surface modification of polypropylene by surface chain transfer reaction based on mussel-inspired adhesion technology and thiol chemistry

International Nuclear Information System (INIS)

Niu, Zhijun; Zhao, Yang; Sun, Wei; Shi, Suqing; Gong, Yongkuan

2016-01-01

Highlights: • Biomimetic surface modification of PP was successfully conducted by integrating mussel-inspired technology, thiol chemistry and cell outer membranes-like structures. • The resultant biomimetic surface exhibits good interface and surface stability. • The obvious suppression of protein adsorption and platelet adhesion is also achieved. • The residue thoil groups on the surface could be further functionalized. - Abstract: Biomimetic surface modification of polypropylene (PP) is conducted by surface chain transfer reaction based on the mussel-inspired versatile adhesion technology and thiol chemistry, using 2-methacryloyloxyethylphosphorylcholine (MPC) as a hydrophilic monomer mimicking the cell outer membrane structure and 2,2-azobisisobutyronitrile (AIBN) as initiator in ethanol. A layer of polydopamine (PDA) is firstly deposited onto PP surface, which not only offers good interfacial adhesion with PP, but also supplies secondary reaction sites (-NH 2 ) to covalently anchor thiol groups onto PP surface. Then the radical chain transfer to surface-bonded thiol groups and surface re-initiated polymerization of MPC lead to the formation of a thin layer of polymer brush (PMPC) with cell outer membrane mimetic structure on PP surface. X-ray photoelectron spectrophotometer (XPS), atomic force microscopy (AFM) and water contact angle measurements are used to characterize the PP surfaces before and after modification. The protein adsorption and platelet adhesion experiments are also employed to evaluate the interactions of PP surface with biomolecules. The results show that PMPC is successfully grafted onto PP surface. In comparison with bare PP, the resultant PP-PMPC surface exhibits greatly improved protein and platelet resistance performance, which is the contribution of both increased surface hydrophilicity and zwitterionic structure. More importantly, the residue thiol groups on PP-PMPC surface create a new pathway to further functionalize such

The Asamblea del Año XIII in the Rio de la Plata: Eternal Laurels to End the Revolution

Directory of Open Access Journals (Sweden)

Esteban Buch

2016-09-01

Full Text Available The Asamblea del año XIII, the 1813 Constitutional Assembly in the Río de la Plata, represents at its best revolutionary velocity, with its allegro rhythm towards wider liberties and a more perfect equality, towards an independence of the nation that, without being officially declared, inspires many of its gestures, like the creation of Argentina’s national anthem. A contemporary observer fond of anachronisms might find in it a confirmation that movement is an essential element of democracy. Yet, this dynamic perception should be balanced by reminding that the Assembly’s main project is not to accelerate the revolution, but to terminate it. “Close the period of the revolution, open the epoch of peace and freedom”, says its inaugural declaration. This paper focuses on the tension between these two conceptions of historical temporality.

Text of an African regional co-operative agreement for research, development and training related to nuclear science and technology

International Nuclear Information System (INIS)

1994-01-01

As of 1 September 1994, notifications of acceptance of the African Regional Co-operative Agreement for Research, Development and Training Related to Nuclear Science and Technology (see INFCIRC/377), in accordance with Article XIII thereof, had been received by the Director General from the Governments of: Tunisia, Egypt, Algeria, Nigeria, Madagascar, Libya, Morocco, Kenya, Sudan, Ghana, Tanzania, Mauritius, Cameroon, South Africa, Zaire, Ethiopia, Zambia, Niger. The Agreement entered into force on 4 April 1990, the date of receipt of the third notification of acceptance

Tomo XIII: ética, equidad e inclusión. Reseña de la Colección Internacional de Investigación Educativa Editorial Redipe 2018

OpenAIRE

Julio César Arboleda

2018-01-01

ÉTICA, EQUIDAD E INCLUSIÓN son los temas centrales de este tomo XIII, inherentes a procesos investigativos y reflexivos. El primer trabajo, por ejemplo, reivindica la visión ética y antropológica de la educación, que sigue constituyendo un pasivo en los procesos de reflexión y formación. Le siguen producciones en torno a la inclusión y la equidad educativa y social. Los demás capítulos constituyen aportaciones de diversas áreas del conocimiento.

The Use of Chemical Modification of Polymer Waste for Obtaining Polymer Flocculants

Institute of Scientific and Technical Information of China (English)

W.W.Sulkowski; K.Nowak; A.Sulkowska; A.Wolin; ska; S.Malanka; W.M.Baldur; D.Pentak

2007-01-01

1 Results Chemical modification of polymer plastic wastes to useful products can be one of the way of effective waste plastics management (chemical recycling). Chemical modification of polymers and polymer plastic wastes can yield products with suitable physical and chemical properties. In consequence they can be used as polyelectrolytes[1]. The variety of pollutants, universality of various water and sewage treatment technologies, introduction of new water quality improved technologies have caused a gr...

Enzymatic modification of starch

DEFF Research Database (Denmark)

Jensen, Susanne Langgård

In the food industry approaches for using bioengineering are investigated as alternatives to conventional chemical and physical starch modification techniques in development of starches with specific properties. Enzyme-assisted post-harvest modification is an interesting approach to this, since...... it is considered a clean and energy saving technology. This thesis aimed to investigate the effect of using reaction conditions, simulating an industrial process, for enzymatic treatment of starch with branching enzyme (BE) from Rhodothermus obamensis. Thus treatements were conducted at 70°C using very high...... substrate concentration (30-40% dry matter (DM)) and high enzyme activity (750-2250 BE units (BEU)/g sample). Starches from various botanical sources, representing a broad range of properties, were used as substrates. The effects of the used conditions on the BE-reaction were evaluated by characterization...

Laser modification of macroscopic properties of metal surface layer

Science.gov (United States)

Kostrubiec, Franciszek

1995-03-01

Surface laser treatment of metals comprises a number of diversified technological operations out of which the following can be considered the most common: oxidation and rendering surfaces amorphous, surface hardening of steel, modification of selected physical properties of metal surface layers. In the paper basic results of laser treatment of a group of metals used as base materials for electric contacts have been presented. The aim of the study was to test the usability of laser treatment from the viewpoint of requirements imposed on materials for electric contacts. The results presented in the paper refer to two different surface treatment technologies: (1) modification of infusible metal surface layer: tungsten and molybdenum through laser fusing of their surface layer and its crystallization, and (2) modification of surface layer properties of other metals through laser doping of their surface layer with foreign elements. In the paper a number of results of experimental investigations obtained by the team under the author's supervision are presented.

Proceedings of VII International Symposium on Nuclear and Related Techniques. XIII Workshop on Nuclear Physics. WONP-NURT 2011

International Nuclear Information System (INIS)

2011-02-01

This year the XIII Workshop on Nuclear Physics (WONP) and the VII Symposium on Nuclear and Related Techniques (NURT) are organized jointly, by Instituto Superior de Tecnologias y Ciencias Aplicadas and Centro de Aplicaciones Tecnologicas y Desarrollo Nuclear. Both events gather scientists from several countries with top research work on nuclear physics and its applications. WONP has been carried out since 1994 promoting an ever-exchanging exchange between professionals of various nuclear and applied physics fields, those related to environmental and health care. NURT is one of the key Cuban scientific meetings since 1997 dealing with the peaceful applications of nuclear techniques in several domains of the society. WONP and NURT provide an unique opportunity for the national and international scientific community to meet outstanding researchers and discuss current trends in several areas of theoretical, experimental and applied nuclear physics and related topics. The papers submitted to this event are presented in this CD-ROM

The hydrophobic modification of gypsum binder by peat products: physico-chemical and technological basis

Directory of Open Access Journals (Sweden)

O. Misnikov

2018-04-01

Full Text Available Gypsum binder is a quick-setting and fast-hardening material that is used widely in the construction industry for plastering and as an ingredient of concrete, other binding materials, etc. The issue addressed here is its short shelf life (around three months which arises because it is hygroscopic, i.e. it readily absorbs moisture and begins to set during transport and storage. The main methods that are currently available for protecting gypsum binder against unwanted exposure to moisture and water vapour are considered, and hydrophobic modification with the bitumen released during peat thermolysis (a method previously considered for cement is proposed as a promising alternative. Because there is overlap in the temperature ranges used in the manufacture of gypsum binder and those required for the initial stages of thermal decomposition of the organic matter in peat, it is expected that hydrophobisation could be achieved during the established manufacturing process without any changes to plant or procedures. The optimum concentration of organic (peat additive for gypsum rock mined from the Shushokskoye deposit in Russia is derived experimentally. With 0.5–1 % of peat additive, the strength grading of the gypsum plaster is preserved and its storage time without caking and hydration increases, even under adverse conditions (100 % relative humidity. The proposed method is compatible with current gypsum production technology, it does not require any changes in equipment, and the prices of mineral raw materials and semi-finished peat products are approximately the same. Thus, the incorporation of hydrophobic modification using peat into the manufacturing process for gypsum binder is unlikely to increase the cost of the product.

Ion bombardment modification of surfaces

International Nuclear Information System (INIS)

Auciello, O.

1984-01-01

An historical overview of the main advances in the understanding of bombardment-induced surface topography is presented. The implantation and sputtering mechanisms which are relevant to ion bombardment modification of surfaces and consequent structural, electronic and compositional changes are described. Descriptions of plasma and ion-beam sputtering-induced film formation, primary ion-beam deposition, dual beam techniques, cluster of molecule ion-beam deposition, and modification of thin film properties by ion bombardment during deposition are presented. A detailed account is given of the analytical and computational modelling of topography from the viewpoint of first erosion theory. Finally, an account of the possible application and/or importance of textured surfaces in technologies and/or experimental techniques not considered in previous chapters is presented. refs.; figs.; tabs

Materiales y técnicas constructivas en la Murcia andalusí (siglos X-XIII

Directory of Open Access Journals (Sweden)

Navarro Palazón, Julio

2011-12-01

Full Text Available The evolution of the materials and building techniques of the andalusian city of Murcia between the 9th and 13th centuries are here studied, mainly based on the new information provided by the numerous archaeological excavations that have been carried out in the city for the last thirty years, related especially to residential architecture. After its accuracy analysis, some differences between the buildings techniques manufactured in the 10th and 11th centuries and those later attributed to 12th and 13th centuries have been identified, being thus highly important to describe them by remarking at the same time those distinguishing features. Problems related to the absolute chronology of these building techniques are also discussed, highlighting the definitive information currently known. With the main aim of analysing how general these remarks are or, on the contrary, if they depend on the regionalization phenomenon characterizing the andalusian recording material, we will compare the information obtained in Murcia with those coming from other andalusian sites, located these far away from the studied area. Finally, we will check if there are differences between the rural and urban environments by comparing the materials and building techniques recorded in two coetaneous sites in Murcia, both sited close to the same river Segura and 40 km distant from each other: the city of Murcia (a large madîna and the deserted settlement of Siyâsa (a hisn.En el presente trabajo estudiamos la evolución de los materiales y técnicas constructivas en la Murcia andalusí, durante un periodo de tiempo que se extiende entre los siglos X y XIII, para lo que nos basaremos especialmente en la rica información extraída de las numerosas excavaciones efectuadas en dicha ciudad, que se refiere sobre todo a arquitectura residencial. Tras su exhaustivo análisis hemos identificado algunas diferencias entre las fábricas de los siglos X y XI y las posteriores de los

Sequence tagging reveals unexpected modifications in toxicoproteomics

Science.gov (United States)

Dasari, Surendra; Chambers, Matthew C.; Codreanu, Simona G.; Liebler, Daniel C.; Collins, Ben C.; Pennington, Stephen R.; Gallagher, William M.; Tabb, David L.

2010-01-01

Toxicoproteomic samples are rich in posttranslational modifications (PTMs) of proteins. Identifying these modifications via standard database searching can incur significant performance penalties. Here we describe the latest developments in TagRecon, an algorithm that leverages inferred sequence tags to identify modified peptides in toxicoproteomic data sets. TagRecon identifies known modifications more effectively than the MyriMatch database search engine. TagRecon outperformed state of the art software in recognizing unanticipated modifications from LTQ, Orbitrap, and QTOF data sets. We developed user-friendly software for detecting persistent mass shifts from samples. We follow a three-step strategy for detecting unanticipated PTMs in samples. First, we identify the proteins present in the sample with a standard database search. Next, identified proteins are interrogated for unexpected PTMs with a sequence tag-based search. Finally, additional evidence is gathered for the detected mass shifts with a refinement search. Application of this technology on toxicoproteomic data sets revealed unintended cross-reactions between proteins and sample processing reagents. Twenty five proteins in rat liver showed signs of oxidative stress when exposed to potentially toxic drugs. These results demonstrate the value of mining toxicoproteomic data sets for modifications. PMID:21214251

Quid facundia posset / re patuit (Οu., Μet. XIII 382-383: the oratorical strategies of Ulysses in the Ovidian armorum iudicium

Directory of Open Access Journals (Sweden)

Eleonora Tola

2010-12-01

Full Text Available In book XIII of his Metamorphoses Ovid presents the contest for the arms of Achilles between Ajax and Ulysses. The speeches that they address to the assembly of Greek show a judicial process according to the norms of Roman rhetoric. Through his traditional facundia Ulysses persuades his public and gains victory after a confrontation that relates to a verbal fight. I will explore the construction of Ulysses’s discursive superiority focusing especially on two key-places of his speech, exordium (128-139 and peroratio (339-381. I will identify different syntactic, metrical and stylistic strategies with which Ulysses captivates his interlocutors. From a metapoetic perspective, Ovid’s tale establishes some resonances between the character’s Fama and its own textual mechanisms.

Conscious design and new technologies for the optimization of therapeutic space

Directory of Open Access Journals (Sweden)

Marzia Morena

2015-04-01

Full Text Available The project Casa pre-dimissioni is aimed at facilitating the recovery of the daily life by whom suffers of disability, adapting domestic spaces to the specific needs of use. The project was developed, under the aegis of the EU research programme DE3207 FACILE: Support tools for housing design and management, integrated with telematics system and services, devoted to disabled and elderly people (TIDE Program, European Commission DG XIII. The main aim of the project was to define and to implement systems that are integrated with information and communications technologies, and with the home-automation products and equipment designed to improve the quality of life of elderly people and of motor-disabled people (paraplegics and cognitive impaired people in their homes.

Similarity Arguments in the Genetic Modification Debate

DEFF Research Database (Denmark)

Christiansen, Andreas

2017-01-01

In the ethical debate on genetic modification (GM), it is common to encounter the claim that some anti-GM argument would also apply an established, ethically accepted technology, and that the anti-GM argument is therefore unsuccessful. The paper discusses whether this argumentative strategy, the ...

Report: Ordine del sentire e apertura al mondo. Filosofia delle emozioni e processo di individuazione della persona XIII Convegno internazionale della Max-Scheler-Gesellschaft Università di Verona 27-30 Maggio 2015

OpenAIRE

Maria Teresa Speranza

2015-01-01

An interesting debate on the issue of personal identity and its ethical implications has animated the days of the XIII International Congress of Max Scheler‐Gesellschaft. A large program of work has garnered numerous perspectives on the philosophy of person and the phenomenology of otherness, investigating in particular the role of emotions in the formation of person process. The main topic of conference was the Max Scheler’s phenomenology of emotions, which is an i...

Radiation modification of materials

International Nuclear Information System (INIS)

Pikaev, A.K.

1987-01-01

Industrial and radiation chemical processes of material modification based on cross-linking of polymers as a result of radiation are considered. Among them are production of cables and rods with irradiated modified insulation, production of hardened and thermo-shrinkaging polymer products (films, tubes, fashioned products), production of radiation cross-linked polyethylene foam, technology of radiation vulcanization of elastomers. Attention is paid to radiation plants on the basis of γ-sources and electron acceleratos as well as to radiation conditions

Las armas de los Limia y sus derivaciones (siglos XIII-XV

Directory of Open Access Journals (Sweden)

Eduardo PARDO DE GUEVARA Y VALDÉS

2011-07-01

Full Text Available En los primeros tiempos del fenómeno emblemático-heráldico, la adopción de unas armerías no respondía a un proceso reflexivo, tal y como ahora parecería natural, sino a unos impulsos espontáneos, en los que predominaba el simple gusto o capricho, cuando no la directa imitación o aceptación de modelos ya existentes, con independencia de la significación o valor social que se les reconociera. Un buen testimonio de ello lo ofrecen las armas traídas ya antes de mediar el siglo XIII por el linaje renombrado Limia, cuyo análisis ofrece lecturas interesantes para comprender el sentido y alcance de estos procedimientos habituales. Como se trata aquí, los palos y palados de los Limia fueron traídos después por los Valcárcel y, más tarde, por un pequeño número de linajes de ellos derivados, aunque las modificaciones introducidas parecen ocultar este origen: las varillas de los Varela, las correas de los Isorna, las lanzas parlantes de los Lanzós -o Lanzones- o las estacas de los Quiroga, así como la losa de los Losada y las fórmulas fusionadas de palos y calderas, cuyo inicio pudo estar en los Biedma y que no tardaría en identificar también al grupo de los Taboada y Noguerol.Aux premiers temps du phénomène emblématique-héraldique, l’adoption d'armoiries répondait moins à un processus réfléchi comme on s’y attendrait aujourd’hui, qu’à des élans spontanés guidés par le simple plaisir ou le caprice, ou même par l’imitation ou l’adoption de quelques modèles déjà existants, indépendamment de la signification ou de la valeur sociale qu’on pourrait leur reconnaître. Tel est le cas des armes portées dans la première moitié du XIIIe siècle par le lignage des Limia, dont l’analyse permet de  comprendre le sens et la portée de ces procédés. Comme il sera dit dans cette étude, les pals et palés des Limia ont été ensuite portés par les Valcárcel et, plus tard, par un petit nombre de lignages

Isotope hydrology investigations in Latin America 1994. Investigations on hydrology and hydrogeology in Latin America on water resources and groundwater pollution. Results achieved during the implementation of the project RLA/8/014 - ARCAL XIII: Application of isotope techniques in hydrology; Estudios de hidrologia isotopica en America Latina 1994. Estudios hidrologicos e hidrogeologicos en America Latina sobre los recursos hidricos y la contaminacion de las aguas subterraneas. Resultados obtenidos en el marco del proyecto RLA/8/014 - ARCAL XIII: Aplicacion de tecnicas isotopicas en hidrologia

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-10-01

This IAEA Technical Document contains 17 articles about the results achieved during the implementation of the project RLA/8/014, ARCAL XIII, aimed at the application of isotope techniques in hydrology in the Caribbean and Latin America. Also included is the list of 19 participants in the project. Refs, figs and tabs.

Safety of Factor XIII Concentrate: Analysis of More than 20 Years of Pharmacovigilance Data

Science.gov (United States)

Solomon, Cristina; Korte, Wolfgang; Fries, Dietmar; Pendrak, Inna; Joch, Christine; Gröner, Albrecht; Birschmann, Ingvild

2016-01-01

Background Plasma-derived factor XIII (FXIII) concentrate is an effective treatment for FXIII deficiency. We describe adverse drug reactions (ADRs) reported during pharmacovigilance monitoring of Fibrogammin®/Corifact® and review published safety data. Methods Postmarketing safety reports recorded by CSL Behring from June 1993 to September 2013 were analyzed. Clinical studies published during the same period were also reviewed. Results Commercial data indicated that 1,653,450,333 IU FXIII concentrate were distributed over the review period, equivalent to 1,181,036 doses for a 70 kg patient. 75 cases were reported (one/15,700 standard doses or 22,046,000 IU). Reports of special interest included 12 cases of possible hypersensitivity reactions (one/98,400 doses or 137,787,500 IU), 7 with possible thromboembolic events (one/168,700 doses or 236,207,200 IU), 5 of possible inhibitor development (one/236,200 doses or 330,690,100 IU), and 20 of possible pathogen transmission (one/59,100 doses or 82,672,500 IU). 19 pathogen transmission cases involved viral infection; 4 could not be analyzed due to insufficient data, but for all others a causal relationship to the product was assessed as unlikely. A review of published literature revealed a similar safety profile. Conclusion Assessment of ADRs demonstrated that FXIII concentrate carries a low risk of ADRs across various clinical situations, suggesting a favorable safety profile. PMID:27781024

Isotope hydrology investigations in Latin America 1994. Investigations on hydrology and hydrogeology in Latin America on water resources and groundwater pollution. Results achieved during the implementation of the project RLA/8/014 - ARCAL XIII: Application of isotope techniques in hydrology

International Nuclear Information System (INIS)

1995-10-01

This IAEA Technical Document contains 17 articles about the results achieved during the implementation of the project RLA/8/014, ARCAL XIII, aimed at the application of isotope techniques in hydrology in the Caribbean and Latin America. Also included is the list of 19 participants in the project. Refs, figs and tabs

Las capillas y capellanías reales castellano-leonesas en la Baja Edad Media (siglos XIII-XV: algunas precisiones institucionales

Directory of Open Access Journals (Sweden)

Nogales Rincón, David

2005-12-01

Full Text Available The study of royal chapels and royal chaplaincies is focus on the analysis of the relationships between de Palace Chapel and the cathedral/monastic royal chapels from a institucional, ideologic and functional criterions, on making a systematization of them and on presenting some general notes about their characteristics, ideal patterns and development in the late Middle Ages in Castille (13th-15th centuries.

El estudio de las capillas y capellanías reales se centra en el análisis de las relaciones entre la Capilla Palacio y las capillas reales catedralicias/monásticas desde un punto de vista institucional, ideológico y funcional, en llevar a cabo una sistematización de éstas y ofrecer algunas notas generales sobre sus características, modelos ideales y evolución en la Castilla bajomedieval (siglos XIII-XV.

Ciudades y poder político en al-Andalus. Una hipótesis sobre el origen de las revueltas urbanas en Murcia en el siglo XIII

Directory of Open Access Journals (Sweden)

Frey Sánchez, Antonio Vicente

2014-12-01

Full Text Available Throughout the 13th century a succession of urban revolts took place in al-Andalus, which caused the withdrawal of the Almohad Empire and the establishment of the third taifas, initially led by Muhammad b. Yūsuf b. Hūd al-Mutawakkil. The inability of this emir to hold together this newly-built state, and the continuous insurrections inside and utside of Murcia have led historians to investigate the nature of political power during this period. This article examines each one of these proposals and, on the basis of an analysis of some socio-economic aspects relating to Murcia (being a representative city of al-Andalus and capital of the hūdí movement during the first half of the thirteenth century, proposes a hypothesis on the nature of its power.Durante el siglo XIII se produjo una serie de revueltas urbanas en al-Andalus que ocasionó la retirada del Imperio almohade y la formación de las terceras taifas, inicialmente encabezadas por Muḥammad b. Yūsuf b. Hūd al-Mutawakkil. La incapacidad de este emir para mantener unido el estado que había creado y las continuas insurrecciones fuera y dentro de Murcia ha llevado a historiadores y filólogos a indagar sobre la naturaleza del poder político en este periodo. Este artículo estudia cada una de estas interpretaciones y, a partir del análisis de algunos aspectos socio-económicos de Murcia, ciudad representativa en al-Andalus y capital del movimiento hūdí durante la primera mitad del siglo XIII, presenta una propuesta sobre la naturaleza de su poder.

Successful design and application of SNCR parallel to combustion modification

Energy Technology Data Exchange (ETDEWEB)

Zhao, Dongxian; Tang, Leping; Shao, Xiaozhen; Meng, Derun; Li, Hongjian [Tongfang Environment CO., LTD., Beijing (China); Zhou, Wei; Xu, Guang [GE Energy, Anaheim, CA (United States)

2013-07-01

Various De-NOx methods have been recently adopted in China to control NOx emissions including Selective Non-Catalytic Reaction (SNCR) technology. Usually, the design of SNCR system is carried out after the combustion modification technologies, such as low NOx burner (LNB) and over fire air (OFA), have already been installed and in operation. This article discusses how to design the SNCR system parallel to the combustion modification. The SNCR process design consists of three steps: (1) boiler baseline test, (2) computational fluid dynamics simulation (CFD) facilitated design and (3) SNCR system performance predictions and optimizations. The first step is to conduct boiler baseline test to characterize the boiler operating conditions at a load range. The test data can also be used to calibrate the CFD model. The second step is to develop a three-dimensional boiler coal combustion CFD model to simulate the operation of the boilers at both baseline and post combustion modification conditions. The simulation reveals velocity, temperature and combustible distributions in the furnace. The last step is to determine the position and numbers of the injectors for SNCR reagent. The final field tests upon the project completion have shown that the average SNCR De-NOx efficiency has reached 35.1% with the maximum removal efficiency of 45% on full load. The project also couples the SNCR and SCR (Selective Catalytic Reduction) technologies. The combined removal efficiency of combustion modifications, SNCR and SCR is higher than 82%. This paper shows a successful example for retrofitting aged power-generating units with limited space.

Double-stabilized neurotensin analogues as potential radiopharmaceuticals for NTR-positive tumors.

Science.gov (United States)

García-Garayoa, Elisa; Maes, Veronique; Bläuenstein, Peter; Blanc, Alain; Hohn, Alexander; Tourwé, Dirk; Schubiger, P August

2006-05-01

Overexpression of neurotensin (NT) receptors in exocrine pancreatic cancer and other neuroendocrine cancers make them interesting targets for tumor imaging and therapy. Modifications at the cleavage bonds 8-9 and 11-12 led to the synthesis of NT-XII, NT-XIII and NT-XVIII, three new stabilized analogues. (NalphaHis)Ac was coupled to the N-terminus for labeling with [(99m)Tc]-tricarbonyl. Stability was tested in vitro in human plasma and HT-29 cells. Binding to NT1 receptors and internalization/efflux were analyzed in intact HT-29 cells. Biodistribution studies were performed in nude mice bearing HT-29 xenografts. All analogues were very stable in human plasma, with half-lives of 20-21 days. Degradation in HT-29 cells was more rapid (t(1/2) of 6.5, 5 and 2.5 h for NT-XII, NT-XIII and NT-XVIII, respectively). They also showed high affinity and specificity for NT1 receptors. Bound activity was rapidly internalized at 37 degrees C. The pattern of externalization was different. NT-XII was released more slowly than NT-XIII and NT-XVIII (half of the activity still inside the cells after 24 h). Bigger differences were found in the biodistribution studies. NT-XII showed the highest tumor uptake as well as the best tumor to nontumor ratios. The modifications introduced in NT(8-13) increased plasma stability, maintaining unaffected the in vitro binding properties. The best biodistribution corresponded to NT-XII, which shows to be a good candidate for NT1 receptors overexpressing tumors. First clinical trials are ongoing.

Ion-beam modification of properties of metals and alloys

International Nuclear Information System (INIS)

Khodasevich, V.V.; Uglov, V.V.; Ponaryadov, V.V.; Zhukova, S.I.

2002-01-01

Physical fundaments for ion-beam modification and plasma-vacuum synthesis of new types of coatings and compounds in technically important metals and alloys were development as well as corresponding installation and technologies were created. (authors)

Surface modification of chitin using ultrasound-assisted and supercritical CO{sub 2} technologies for cobalt adsorption

Energy Technology Data Exchange (ETDEWEB)

Dotto, Guilherme L., E-mail: guilherme_dotto@yahoo.com.br; Cunha, Jeanine M., E-mail: jeaninecunha@gmail.com; Calgaro, Camila O., E-mail: camila.itepjr@gmail.com; Tanabe, Eduardo H., E-mail: edutanabe@yahoo.com.br; Bertuol, Daniel A., E-mail: dbertuol@gmail.com

2015-09-15

Highlights: • Chitin was modified by ultrasound-assisted (UA) and supercritical (SCO{sub 2}) technologies. • Chitin, UA-chitin and SCO{sub 2}-chitin were used as adsorbents for Co(II). • UA and SCO{sub 2} treatments provided increase of 20 and 3 times in chitin surface area. • The Co(II) adsorption capacity increased until 67.8%, using UA-chitin. - Abstract: Ultrasound-assisted (UA) and supercritical CO{sub 2} technologies (SCO{sub 2}) were used to modify the chitin surface and, improve its adsorption characteristics regarding to cobalt. Chitin, before and after the treatments, was characterized by N{sub 2} adsorption isotherms (BET), infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscopy (SEM). Unmodified and surface modified chitins were used as adsorbents to remove cobalt from aqueous solutions. The adsorption study was performed by equilibrium isotherms and kinetic curves. The chitin particle characteristics, such as, surface area, pore volume and porosity were improved by the UA and SCO{sub 2} treatments. The crystallinity index decreased after the UA and SCO{sub 2} treatments, and also, intense surface modifications were observed. Langmuir and Freundlich models were adequate to represent the adsorption equilibrium. The maximum adsorption capacities were 50.03, 83.94 and 63.08 mg g{sup −1} for unmodified chitin, UA surface modified chitin and SCO{sub 2} surface modified chitin. The adsorption kinetic curves were well represented by the pseudo-second order model. UA and SCO{sub 2} technologies are alternatives to modify the chitin surface and improve its adsorption characteristics.

Surface modification of polyester biomaterials for tissue engineering

International Nuclear Information System (INIS)

Jiao Yanpeng; Cui Fuzhai

2007-01-01

Surfaces play an important role in a biological system for most biological reactions occurring at surfaces and interfaces. The development of biomaterials for tissue engineering is to create perfect surfaces which can provoke specific cellular responses and direct new tissue regeneration. The improvement in biocompatibility of biomaterials for tissue engineering by directed surface modification is an important contribution to biomaterials development. Among many biomaterials used for tissue engineering, polyesters have been well documented for their excellent biodegradability, biocompatibility and nontoxicity. However, poor hydrophilicity and the lack of natural recognition sites on the surface of polyesters have greatly limited their further application in the tissue engineering field. Therefore, how to introduce functional groups or molecules to polyester surfaces, which ideally adjust cell/tissue biological functions, becomes more and more important. In this review, recent advances in polyester surface modification and their applications are reviewed. The development of new technologies or methods used to modify polyester surfaces for developing their biocompatibility is introduced. The results of polyester surface modifications by surface morphological modification, surface chemical group/charge modification, surface biomacromolecule modification and so on are reported in detail. Modified surface properties of polyesters directly related to in vitro/vivo biological performances are presented as well, such as protein adsorption, cell attachment and growth and tissue response. Lastly, the prospect of polyester surface modification is discussed, especially the current conception of biomimetic and molecular recognition. (topical review)

“Et qui or me vaurra entendre, cuer et oreilles me doit rendre”: espacios de lectura y público de los roman courtois de Chrétien de Troyes (siglos XII-XIII

Directory of Open Access Journals (Sweden)

Diego Carlo Améndolla Spinola

2016-06-01

Full Text Available Basado en los planteamientos de la lógica social del texto, este artículo presenta un estudio del público que escuchaba los romances corteses entre los siglo XII y XIII, específicamente los realizados por Chrétien de Troyes –clérigo lector de la Corte de Leonor de Aquitania y de Enrique II Plantagenet–, además de establecer y analizar las diversas salas de los castillos donde estas obras literarias eran narradas.

Radiation modification of glass fiber - reinforced plastics

International Nuclear Information System (INIS)

Allayarov, S.R.; Smirnov, Yu.N.; Lesnichaya, V.A.; Ol'khov, Yu.A.; Belov, G.P.; Dixon, D.A.; Kispert, L.D.

2007-01-01

Modification of glass fiber - reinforced plastics (GFRPs) by gamma-irradiation has been researched to receipt of polymeric composite materials. They were produced by the film - technology method and the cheapest thermoplastics (polythene, polyamide were used as polymeric matrixes for their manufacture. GFRPs were irradiated with Co 60 gamma-rays from a Gammatok-100 source in air and in vacuum. The strength properties of GFRPs and initial polymeric matrixes were investigated before and after radiolysis. Molecular - topological structure of the polymeric matrixes were tested by the method of thermomechanical spectroscopy. The strength properties of GFRPs depend on a parity of speeds of structural (physical) and chemical modification of the polymeric matrixes. These two processes proceed simultaneously. The structural modification includes physical transformation of polymers at preservation of their chemical structure. Covalent bonds between various macromolecules or between macromolecules and surface of fiberglasses are formed at the chemical modification of polymeric matrixes induced by radiation. Action of ionizing radiation on the used polymeric matrix results to its structurization (polythene) or to destruction (polyamide). Increasing of durability of GFRPs containing polythene is caused by formation of the optimum molecular topological structure of the polymeric matrix. (authors)

Determinants of consumer attitudes and purchase intentions with regard to genetically modifed foods

DEFF Research Database (Denmark)

Bredahl, Lone

2001-01-01

of the technology. Purchase decisions with regard to the two product examples were almost exclusively determined by attitudes towards purchasing the products. These were, in turn, significantly influenced by the overall attitude towards genetic modification in food production through their effects on beliefs held...... which was carried out in Denmark, Germany, Italy and the United Kingdom to investigate the formation of consumer attitudes towards genetic modification in food production and of purchase decisions with regard to genetically modified yoghurt and beer. Altogether, 2031 consumers were interviewed...... consumers. Across countries, the attitude towards genetic modification in food production was deeply embedded in more general attitudes held by the consumers, in particular attitude towards nature and attitude towards technology. These general attitudes were found to influence perceived risks and benefits...

A Kantian argument against comparatively advantageous genetic modification.

Science.gov (United States)

Jensen, David

2011-08-01

The genetic modification of children is becoming a more likely possibility given our rapid progress in medical technologies. I argue, from a broadly Kantian point of view, that at least one kind of such modification-modification by a parent for the sake of a child's comparative advantage-is not rationally justified. To argue this, I first characterize a necessary condition on reasons and rational justification: what is a reason for an agent to do an action in one set of circumstances must be a reason for any in those circumstances to do the action. I then show that comparatively advantageous genetic modification violates this principle since a child's "getting ahead" through genetic modification cannot be rationally justified unless other children also could receive the modification, thus rendering the advantage useless. Finally, I consider the major objection to this it seems to disallow all cases of a parent's helping a child get ahead, something that parents normally engage in with their children. I argue that typical practices of developing a comparative advantage in a child, as well as practices of societal competition in general, do not conflict because they involve circumstances that mitigate the universal character of reasons. Many ordinary cases of competitive advantage that we think of as unjust, in fact, can be explained by my argument.

Modern and prospective technologies for weather modification activities: Developing a framework for integrating autonomous unmanned aircraft systems

Science.gov (United States)

DeFelice, T. P.; Axisa, Duncan

2017-09-01

This paper builds upon the processes and framework already established for identifying, integrating and testing an unmanned aircraft system (UAS) with sensing technology for use in rainfall enhancement cloud seeding programs to carry out operational activities or to monitor and evaluate seeding operations. We describe the development and assessment methodologies of an autonomous and adaptive UAS platform that utilizes in-situ real time data to sense, target and implement seeding. The development of a UAS platform that utilizes remote and in-situ real-time data to sense, target and implement seeding deployed with a companion UAS ensures optimal, safe, secure, cost-effective seeding operations, and the dataset to quantify the results of seeding. It also sets the path for an innovative, paradigm shifting approach for enhancing precipitation independent of seeding mode. UAS technology is improving and their application in weather modification must be explored to lay the foundation for future implementation. The broader significance lies in evolving improved technology and automating cloud seeding operations that lowers the cloud seeding operational footprint and optimizes their effectiveness and efficiency, while providing the temporal and spatial sensitivities to overcome the predictability or sparseness of environmental parameters needed to identify conditions suitable for seeding, and how such might be implemented. The dataset from the featured approach will contain data from concurrent Eulerian and Lagrangian perspectives over sub-cloud scales that will facilitate the development of cloud seeding decision support tools.

Integration of microplasma and microfluidic technologies for localised microchannel surface modification

Science.gov (United States)

Szili, Endre J.; Al-Bataineh, Sameer A.; Priest, Craig; Gruner, Philipp J.; Ruschitzka, Paul; Bradley, James W.; Ralston, John; Steele, David A.; Short, Robert D.

2011-12-01

In this paper we describe the spatial surface chemical modification of bonded microchannels through the integration of microplasmas into a microfluidic chip (MMC). The composite MMC comprises an array of precisely aligned electrodes surrounding the gas/fluid microchannel. Pairs of electrodes are used to locally ignite microplasmas inside the microchannel. Microplasmas, comprising geometrically confined microscopic electrically-driven gas discharges, are used to spatially functionalise the walls of the microchannels with proteins and enzymes down to scale lengths of 300 μm inside 50 μm-wide microchannels. Microchannels in poly(dimethylsiloxane) (PDMS) or glass were used in this study. Protein specifically adsorbed on to the regions inside the PDMS microchannel that were directly exposed to the microplasma. Glass microchannels required pre-functionalisation to enable the spatial patterning of protein. Firstly, the microchannel wall was functionalised with a protein adhesion layer, 3-aminopropyl-triethoxysilane (APTES), and secondly, a protein blocking agent (bovine serum albumin, BSA) was adsorbed onto APTES. The functionalised microchannel wall was then treated with an array of spatially localised microplasmas that reduced the blocking capability of the BSA in the region that had been exposed to the plasma. This enabled the functionalisation of the microchannel with an array of spatially separated protein. As an alternative we demonstrated the feasibility of depositing functional thin films inside the MMC by spatially plasma depositing acrylic acid and 1,7-octadiene within the microchannel. This new MMC technology enables the surface chemistry of microchannels to be engineered with precision, which is expected to broaden the scope of lab-on-a-chip type applications.

Quando rey perdemos nunq[u]a bien nos fallamos. La muerte del rey en la Castilla del siglo XIII

Directory of Open Access Journals (Sweden)

Pérez Monzón, Olga

2007-12-01

Full Text Available This article deals with the funeral spaces of the Castilian kings during the 13th century, and the iconography of their tombs as the reflection of a political ideational system tending toward the sanctification of the monarchy. This elevation of royalty provoked an open conflict with certain members of the nobility and the royal family, as well as a political and artistic response.

El presente artículo trata sobre los ámbitos fúnebres de los reyes castellanos durante el siglo XIII y la particularidad iconográfica de sus monumentos tumulares como reflejo de un ideario político tendente a la sacralización de la monarquía. El encumbramiento de la realeza provocó un abierto conflicto con determinados miembros de la realeza y la familia real y una respuesta política y artística.

Evaluating Factor XIII Specificity for Glutamine-Containing Substrates Using a MALDI-TOF Mass Spectrometry Assay

Science.gov (United States)

Doiphode, Prakash G.; Malovichko, Marina V.; Mouapi, Kelly Njine; Maurer, Muriel C.

2014-01-01

Activated Factor XIII (FXIIIa) catalyzes the formation of γ-glutamyl-ε-lysyl cross-links within the fibrin blood clot network. Although several cross-linking targets have been identified, the characteristic features that define FXIIIa substrate specificity are not well understood. To learn more about how FXIIIa selects its targets, a matrix-assisted laser desorption ionization – time of flight mass spectrometry (MALDI-TOF MS) based assay was developed that could directly follow the consumption of a glutamine-containing substrate and the formation of a cross-linked product with glycine ethylester. This FXIIIa kinetics assay is no longer reliant on a secondary coupled reaction, on substrate labeling, or on detecting the final deacylation portion of the transglutaminase reaction. With the MALDI-TOF MS assay, glutamine-containing peptides derived from α2-antiplasmin, S. Aureus fibronectin binding protein A, and thrombin activatable fibrinolysis inhibitor were examined directly. Results suggest that the FXIIIa active site surface responds to changes in substrate residues following the reactive glutamine. The P-1 substrate position is sensitive to charge character and the P-2 and P-3 to the broad FXIIIa substrate specificity pockets. The more distant P-8 to P-11 region serves as a secondary substrate anchoring point. New knowledge on FXIIIa specificity may be used to design better substrates or inhibitors of this transglutaminase. PMID:24751466

Machining, joining and modifications of advanced materials

CERN Document Server

Altenbach, Holm

2016-01-01

This book presents the latest advances in mechanical and materials engineering applied to the machining, joining and modification of modern engineering materials. The contributions cover the classical fields of casting, forming and injection moulding as representative manufacturing methods, whereas additive manufacturing methods (rapid prototyping and laser sintering) are treated as more innovative and recent technologies that are paving the way for the manufacturing of shapes and features that traditional methods are unable to deliver. The book also explores water jet cutting as an innovative cutting technology that avoids the heat build-up typical of classical mechanical cutting. It introduces readers to laser cutting as an alternative technology for the separation of materials, and to classical bonding and friction stir welding approaches in the context of joining technologies. In many cases, forming and machining technologies require additional post-treatment to achieve the required level of surface quali...

Machinability of Minor Wooden Species before and after Modification with Thermo-Vacuum Technology.

Science.gov (United States)

Sandak, Jakub; Goli, Giacomo; Cetera, Paola; Sandak, Anna; Cavalli, Alberto; Todaro, Luigi

2017-01-28

The influence of the thermal modification process on wood machinability was investigated with four minor species of low economic importance. A set of representative experimental samples was machined to the form of disks with sharp and dull tools. The resulting surface quality was visually evaluated by a team of experts according to the American standard procedure ASTM D-1666-87. The objective quantification of the surface quality was also done by means of a three dimensions (3D) surface scanner for the whole range of grain orientations. Visual assessment and 3D surface analysis showed a good agreement in terms of conclusions. The best quality of the wood surface was obtained when machining thermally modified samples. The positive effect of the material modification was apparent when cutting deodar cedar, black pine and black poplar in unfavorable conditions (i.e., against the grain). The difference was much smaller for an easy-machinability specie such as Italian alder. The use of dull tools resulted in the worst surface quality. Thermal modification has shown a very positive effect when machining with dull tools, leading to a relevant increment of the final surface smoothness.

Contribution to the study of plasmatic fibrinogen and serum albumin: effects of irradiation

International Nuclear Information System (INIS)

Suscillon, M.

1967-01-01

The author studies the modifications of properties and structure of serum albumin and fibrinogen solution when subjected to radiation of low energy (X rays). On the other hand, two original techniques are exposed: 1. Amperometric determination of fibrin stabilizing factor or factor XIII of hemostasis. 2. Spectrophotometric study of fibrin formation kinetics. Then showing off and quantitative determination of platelets fibrinogen is exposed. (author) [fr

Plasma surface modification of rigid contact lenses decreases bacterial adhesion.

Science.gov (United States)

Wang, Yingming; Qian, Xuefeng; Zhang, Xiaofeng; Xia, Wei; Zhong, Lei; Sun, Zhengtai; Xia, Jing

2013-11-01

Contact lens safety is an important topic in clinical studies. Corneal infections usually occur because of the use of bacteria-carrying contact lenses. The current study investigated the impact of plasma surface modification on bacterial adherence to rigid contact lenses made of fluorosilicone acrylate materials. Boston XO and XO2 contact lenses were modified using plasma technology (XO-P and XO2-P groups). Untreated lenses were used as controls. Plasma-treated and control lenses were incubated in solutions containing Staphylococcus aureus or Pseudomonas aeruginosa. MTT colorimetry, colony-forming unit counting method, and scanning electron microscopy were used to measure bacterial adhesion. MTT colorimetry measurements showed that the optical density (OD) values of XO-P and XO2-P were significantly lower than those of XO and XO2, respectively, after incubation with S. aureus (P lenses and to the XO2-P versus XO2 lenses incubated with S. aureus (P lenses incubated with P. aeruginosa (P lenses. Plasma surface modification can significantly decrease bacterial adhesion to fluorosilicone acrylate contact lenses. This study provides important evidence of a unique benefit of plasma technology in contact lens surface modification.

Double-stabilized neurotensin analogues as potential radiopharmaceuticals for NTR-positive tumors

Energy Technology Data Exchange (ETDEWEB)

Garcia-Garayoa, Elisa [Center for Radiopharmaceutical Science, Paul Scherrer Institute, CH-5232 Villigen PSI (Switzerland)]. E-mail: elisa.garcia@psi.ch; Maes, Veronique [Vrije Universiteit Brussel, Department of Organic Chemistry, B-1050 Brussel (Belgium); Blaeuenstein, Peter [Center for Radiopharmaceutical Science, Paul Scherrer Institute, CH-5232 Villigen PSI (Switzerland); Blanc, Alain [Center for Radiopharmaceutical Science, Paul Scherrer Institute, CH-5232 Villigen PSI (Switzerland); Hohn, Alexander [Center for Radiopharmaceutical Science, Paul Scherrer Institute, CH-5232 Villigen PSI (Switzerland); Tourwe, Dirk [Vrije Universiteit Brussel, Department of Organic Chemistry, B-1050 Brussel (Belgium); Schubiger, P. August [Center for Radiopharmaceutical Science, Paul Scherrer Institute, CH-5232 Villigen PSI (Switzerland)

2006-05-15

Introduction: Overexpression of neurotensin (NT) receptors in exocrine pancreatic cancer and other neuroendocrine cancers make them interesting targets for tumor imaging and therapy. Modifications at the cleavage bonds 8-9 and 11-12 led to the synthesis of NT-XII, NT-XIII and NT-XVIII, three new stabilized analogues. (N{alpha}His)Ac was coupled to the N-terminus for labeling with [{sup 99m}Tc]-tricarbonyl. Methods: Stability was tested in vitro in human plasma and HT-29 cells. Binding to NT1 receptors and internalization/efflux were analyzed in intact HT-29 cells. Biodistribution studies were performed in nude mice bearing HT-29 xenografts. Results: All analogues were very stable in human plasma, with half-lives of 20-21 days. Degradation in HT-29 cells was more rapid (t {sub 1/2} of 6.5, 5 and 2.5 h for NT-XII, NT-XIII and NT-XVIII, respectively). They also showed high affinity and specificity for NT1 receptors. Bound activity was rapidly internalized at 37{sup o}C. The pattern of externalization was different. NT-XII was released more slowly than NT-XIII and NT-XVIII (half of the activity still inside the cells after 24 h). Bigger differences were found in the biodistribution studies. NT-XII showed the highest tumor uptake as well as the best tumor to nontumor ratios. Conclusion: The modifications introduced in NT(8-13) increased plasma stability, maintaining unaffected the in vitro binding properties. The best biodistribution corresponded to NT-XII, which shows to be a good candidate for NT1 receptors overexpressing tumors. First clinical trials are ongoing.

Double-stabilized neurotensin analogues as potential radiopharmaceuticals for NTR-positive tumors

International Nuclear Information System (INIS)

Garcia-Garayoa, Elisa; Maes, Veronique; Blaeuenstein, Peter; Blanc, Alain; Hohn, Alexander; Tourwe, Dirk; Schubiger, P. August

2006-01-01

Introduction: Overexpression of neurotensin (NT) receptors in exocrine pancreatic cancer and other neuroendocrine cancers make them interesting targets for tumor imaging and therapy. Modifications at the cleavage bonds 8-9 and 11-12 led to the synthesis of NT-XII, NT-XIII and NT-XVIII, three new stabilized analogues. (NαHis)Ac was coupled to the N-terminus for labeling with [ 99m Tc]-tricarbonyl. Methods: Stability was tested in vitro in human plasma and HT-29 cells. Binding to NT1 receptors and internalization/efflux were analyzed in intact HT-29 cells. Biodistribution studies were performed in nude mice bearing HT-29 xenografts. Results: All analogues were very stable in human plasma, with half-lives of 20-21 days. Degradation in HT-29 cells was more rapid (t 1/2 of 6.5, 5 and 2.5 h for NT-XII, NT-XIII and NT-XVIII, respectively). They also showed high affinity and specificity for NT1 receptors. Bound activity was rapidly internalized at 37 o C. The pattern of externalization was different. NT-XII was released more slowly than NT-XIII and NT-XVIII (half of the activity still inside the cells after 24 h). Bigger differences were found in the biodistribution studies. NT-XII showed the highest tumor uptake as well as the best tumor to nontumor ratios. Conclusion: The modifications introduced in NT(8-13) increased plasma stability, maintaining unaffected the in vitro binding properties. The best biodistribution corresponded to NT-XII, which shows to be a good candidate for NT1 receptors overexpressing tumors. First clinical trials are ongoing

Modification of unsaturated polyester resins using nano-size core ...

African Journals Online (AJOL)

Modification of unsaturated polyester resins using nano-size core-shell particles. MO Munyati, PA Lovell. Abstract. No Abstract Available Journal of Science and Technology Special Edition 2004: 24-31. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT.

Modification of biomolecules and combined actions by radiation

International Nuclear Information System (INIS)

Kim, Jin Kyu; Lee, J. W.; Kim, J. H.; Choi, J. I.; Song, B. S.; Kim, J. K.; Park, J. H.; Lee, Y. J.; Ryu, S. H.; Sung, N. Y.; Cha, M. K.; Nam, J. Y.; Park, J. Y.; Cho, E. R.; Ryu, T. H.

2011-12-01

Advanced Radiation Technology Institute is a government-supported institute for radiation research and application. It has focused on development of fundamentals for radiation applications based on the existing radiation technology, and on enhancement of biological effectiveness of radiation through theoretical approach to the combined actions of radiation with another factor. Application of radiation technology together with the existing technologies to enhance the physical, chemical, biological characteristics through modification of biomolecules resulted in creation of de novo materials of scientific and industrial values. A theoretical model for combined action of radiation with another physico-chemical factor has been established. Conclusively the results of this study can provide scientific bases for maximizing the efficacy of ionizing radiation in relation to industrial applications

Photon technology. Laser process technology; Photon technology. Laser process gijutsu

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-03-01

For developing laser process technology by interaction between substance and photon, the present state, system, R and D issues and proposal of such technology were summarized. Development of the photon technology aims at the modification of bonding conditions of substances by quantum energy of photon, and the new process technology for generating ultra- high temperature and pressure fields by concentrating photon on a minute region. Photon technology contributes to not only the conventional mechanical and thermal forming and removal machining but also function added machining (photon machining) in quantum level and new machining technology ranging from macro- to micro-machining, creating a new industrial field. This technology extends various fields from the basis of physics and chemistry to new bonding technology. Development of a compact high-quality high-power high-efficiency photon source, and advanced photon transmission technology are necessary. The basic explication of an unsolved physicochemical phenomenon related to photon and substance, and development of related application technologies are essential. 328 refs., 147 figs., 13 tabs.

A novel modification of the Turing test for artificial intelligence and robotics in healthcare.

Science.gov (United States)

Ashrafian, Hutan; Darzi, Ara; Athanasiou, Thanos

2015-03-01

The increasing demands of delivering higher quality global healthcare has resulted in a corresponding expansion in the development of computer-based and robotic healthcare tools that rely on artificially intelligent technologies. The Turing test was designed to assess artificial intelligence (AI) in computer technology. It remains an important qualitative tool for testing the next generation of medical diagnostics and medical robotics. Development of quantifiable diagnostic accuracy meta-analytical evaluative techniques for the Turing test paradigm. Modification of the Turing test to offer quantifiable diagnostic precision and statistical effect-size robustness in the assessment of AI for computer-based and robotic healthcare technologies. Modification of the Turing test to offer robust diagnostic scores for AI can contribute to enhancing and refining the next generation of digital diagnostic technologies and healthcare robotics. Copyright © 2014 John Wiley & Sons, Ltd.

O moio-medida e o moio dos preços em Portugal nos séculos Xl a XIII

Directory of Open Access Journals (Sweden)

Seabra Lopes, Luis

2005-06-01

Full Text Available In this paper, the value of the modius (modio, moyo, moio in Portugal in the 11th to the 13th centuries is studied. By this time, the modius was both a measure of capacity and a unit used in the specification of prices. The author concludes that, while the modius-measure had a capacity not under the horse charge (210 to 220 litters in the legal systems used in Portugal from the end of the 11th century onwards, some smaller modii continued to be used in rural areas far away from the main urban centers. These smaller modii had a capacity around 50 to 75 litters. With respect to the modius-price, the information gathered by the author indicates a value between 25 and 55 litters of cereal. Therefore, it becomes clear that the modius-price was not equivalent to the standard modius-measure, although it could be equivalent to the smaller modii still in use in rural areas. The gathered evidence also suggests that, from the 10th to the 13th centuries, independently of inflation, the modius-price remained approximately equivalent to the currency unit known as solidus

Neste artigo, estuda-se o valor do moio (modius, modio, moyo em Portugal nos séculos XI a XIII. Nesta época, o moio era simultaneamente uma medida de capacidade e uma unidade usada na especificação dos preços. Este estudo permite concluir que, enquanto o moio-medida tinha, nos sistemas legais em vigor em Portugal a partir de finais do século XI, uma capacidade não inferior à carga de cavalo (210 a 220 litros, alguns moios mais pequenos continuaram a ser utilizados em áreas rurais afastadas dos principais centros urbanos. Estes moios mais pequenos tinham capacidades em torno de 50 a 75 litros. Relativamente ao moi-preço, a informação reunida indica um valor entre 25 e 55 litros de cereal, Torna-se, assim, evidente, que o moio-preço não era equivalente ao moio-medida comum, podendo, no entanto, ser equivalente aos moios menores que ainda sobreviviam nas áreas rurais. A

Enhancing the functional properties of thermophilic enzymes by chemical modification and immobilization.

Science.gov (United States)

Cowan, Don A; Fernandez-Lafuente, Roberto

2011-09-10

The immobilization of proteins (mostly typically enzymes) onto solid supports is mature technology and has been used successfully to enhance biocatalytic processes in a wide range of industrial applications. However, continued developments in immobilization technology have led to more sophisticated and specialized applications of the process. A combination of targeted chemistries, for both the support and the protein, sometimes in combination with additional chemical and/or genetic engineering, has led to the development of methods for the modification of protein functional properties, for enhancing protein stability and for the recovery of specific proteins from complex mixtures. In particular, the development of effective methods for immobilizing large multi-subunit proteins with multiple covalent linkages (multi-point immobilization) has been effective in stabilizing proteins where subunit dissociation is the initial step in enzyme inactivation. In some instances, multiple benefits are achievable in a single process. Here we comprehensively review the literature pertaining to immobilization and chemical modification of different enzyme classes from thermophiles, with emphasis on the chemistries involved and their implications for modification of the enzyme functional properties. We also highlight the potential for synergies in the combined use of immobilization and other chemical modifications. Copyright © 2011 Elsevier Inc. All rights reserved.

Tres Violantes: las mujeres de una familia en el poder a lo largo del siglo XIII

Directory of Open Access Journals (Sweden)

Fuente Pérez, María Jesús

2016-06-01

Full Text Available The power of women, in particular the power of queens, has been a topic of great interest to historians, medievalists in particular; though much has been written about the subject, many questions remain. “Three Violantes” will look at the role of two Iberian queens and one Spanish princess in the thirteenth century Iberian kingdoms. In England and in other European kingdoms of that time, queens had lost authority and their agency was limited to the power of intercession and mediation, I will try to determine whether this also holds true for the Iberian queens.El interés por el tema del poder de las mujeres, en particular de las reinas, ha planteado muchos interrogantes sobre la naturaleza de ese poder. “Tres Violantes” examina la participación de dos reinas y una infanta de una misma familia, en aspectos diversos de la vida de las coronas de Aragón y Castilla en el siglo XIII, con el objetivo de apreciar si el papel de las reinas hispanas, en particular su participación política, siguió un camino similar al de las reinas de ese tiempo que, como bien se ha estudiado para las inglesas, fueron perdiendo autoridad y se vieron limitadas a ejercer poder a través de la intercesión y mediación.

Influence of Modification and Casting Technology on Structure of IN-713C Superalloy Castings

Directory of Open Access Journals (Sweden)

Binczyk F.

2016-09-01

Full Text Available The paper presents the results concerning impact of modification (volume and surface techniques, pouring temperature and mould temperature on stereological parameters of macrostructure in IN713C castings made using post-production scrap. The ability to adjust the grain size is one of the main issues in the manufacturing of different nickel superalloy castings used in aircraft engines. By increasing the grain size one can increase the mechanical properties, like diffusion creep resistance, in higher temperatures. The fine grained castings. on the other hand, have higher mechanical properties in lower temperatures and higher resistance to thermal fatigue. The test moulds used in this study, supplied by Pratt and Whitney Rzeszow, are ordinarily used to cast the samples for tensile stress testing. Volume modification was carried out using the patented filter containing cobalt aluminate. The macrostructure was described using the number of grains per mm2, mean grain surface area and shape index. Obtained results show strong relationship between the modification technique, pouring temperature and grain size. There was no significant impact of mould temperature on macrostructure.

Stroke rehabilitation: assistive technology devices and environmental modifications following primary rehabilitation in hospital--a therapeutic perspective

DEFF Research Database (Denmark)

Sørensen, Hanne Vinkel; Lendal, Susie; Schultz-Larsen, Kirsten

2003-01-01

The aim of this article is to describe the need for assistive devices and environmental modifications among long-living stroke survivors and to investigate if the need is continued and growing over time. The study sample of 155 consecutive stroke patients with stroke-related impairment, discharged...... home from three hospitals in Copenhagen from 1996 through 1998, constituted 20% of the total population of stroke survivors in this area. The results showed that 75% of these patients were provided with assistive devices and/or environmental modifications at discharge. Six months after discharge...... be required in order to target stroke survivors' changing needs for assistive devices and environmental modifications....

[Powder modification technology used for the preparation of the hydrophilic decoction pieces of indigo naturalis and the modification principle].

Science.gov (United States)

Zhang, Ding-Kun; Lin, Jun-Zhi; Liu, Jian-Yun; Qin, Chun-Feng; Guo, Zhi-Ping; Han, Li; Yang, Ming

2013-07-01

The hydrophilicity of the normal decoction pieces (NDP) of Indigo Naturalis is not good, therefore, it is not suit for decoctions. In this paper, powder modification technology is used and some NDP and alcohol are ground together in the vibromill to prepare the hydrophilic decoction pieces (HDP) of Indigo Naturalis. Initially, the properties of NDP, ultrafine decoction pieces (UDP) and HDP are compared, the hydrophilicity of UDP was promoted slightly, that of HDP is promoted dramatically. Then, three batches of Indigo Naturalis are prepared to HDP separately, but there is no obvious difference in the contact angle. Furthermore, the size distribution, surface area and micro-shape of HDP are bigger than that of UDP and smaller than NDP. The contents of indigo and indirubin in three decoction pieces are the same, as well as the species of inorganic substance, although there is a little difference in the proportion of five inorganic substances. The fact suggests the change of physical state and the qualitative and quantitative change of organism and inorganic substances are not the main factors to influence the hydrophilicity. In addition, hydroxyl, methylene and methyl can be identified at the wavenumber of 3 356 cm(-1) and 1 461 cm(-1) in infrared spectrum; the content of alcohol in HDP is 0.67% measured by gas chromatogram. The stability of HDP in the heating condition is studied, the fact suggests the hydrophilic effect of HDP at 40 degrees C is relatively stable. All above research suggests that the alcohol is the main factor to influence the hydrophilicity and maybe the intermolecular force which fixed alcohol molecule on the surface of Indigo Naturalis is the basic principle to produce the hydrophilicity.

O-GlcNAc modification: why so intimately associated with phosphorylation?

Directory of Open Access Journals (Sweden)

Ande Sudharsana R

2011-01-01

Full Text Available Abstract Post-translational modification of proteins at serine and threonine side chains by β-N-acetylglucosamine (O-GlcNAc mediated by the enzyme β-N-acetylglucosamine transferase has been emerging as a fundamental regulatory mechanism encompassing a wide range of proteins involved in cell division, metabolism, transcription and cell signaling. Furthermore, an extensive interplay between O-GlcNAc modification and serine/threonine phosphorylation in a variety of proteins has been reported to exist. However, our understanding of the regulatory mechanisms involved in O-GlcNAc modification and its interplay with serine/threonine phosphorylation in proteins is still elusive. Recent success in the mapping of O-GlcNAc modification sites in proteins as a result of technological advancement in mass spectrometry have revealed two important clues which may be inherently connected to the regulation of O-GlcNAc modification and its interplay with phosphorylation in proteins. First, almost all O-GlcNAc modified proteins are known phospho proteins. Second, the prevalence of tyrosine phosphorylation among O-GlcNAc modified proteins is exceptionally higher (~68% than its normal occurrence (~2% alone. We hypothesize that phosphorylation may be a requisite for O-GlcNAc modification and tyrosine phosphorylation plays a role in the interplay between O-GlcNAc modification and serine/threonine phosphorylation in proteins. In other words, the interplay between O-GlcNAc modification and phosphorylation is not limited to serine/threonine phosphorylation but also includes tyrosine phosphorylation. Our hypothesis provides an opportunity to understand the underlying mechanism involved in O-GlcNAc modification and its interplay with serine/threonine phosphorylation in proteins. Furthermore, implication of our hypothesis extends to tyrosine kinase signaling.

Chemical Strategies for the Covalent Modification of Filamentous Phage

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Matthew B Francis

2014-12-01

Full Text Available Historically filamentous bacteriophage have been known to be the workhorse of phage display due to their ability to link genotype to phenotype. More recently, the filamentous phage scaffold has proved to be powerful outside the realms of phage display technology in fields such as molecular imaging, cancer research and materials and vaccine development. The ability of the virion to serve as a platform for a variety of applications heavily relies on the functionalization of the phage coat proteins with a wide variety of functionalities. Genetic modification of the coat proteins has been the most widely used strategy for functionalizing the virion; however complementary chemical modification strategies can help to diversify the range of materials that can be developed. This review emphasizes the recent advances that have been made in the chemical modification of filamentous phage as well as some of the challenges that are involved functionalizing the virion.

The Effects of Technological Modifications on the Fermentation of ...

African Journals Online (AJOL)

... load of borde from all the above treatments. It was found possible to shorten the duration and simplify the technology of borde fermentation with some variations in acceptability. Key Words: food processing; traditional fermentation; cereal beverage, borde; Ethiopia Journal of Food Technology in Africa Vol.9(1) 2004: 3-12 ...

Homens de letras e homens de leis ao serviço da monarquia portuguesa (séculos XII-XIII

Directory of Open Access Journals (Sweden)

Armando Norte

2014-06-01

Full Text Available Ao longo da primeira dinastia, os letrados ao serviço da Coroa portuguesa desempenharam um papel decisivo e cada vez mais importante na afirmação do poder real. Homens de leis e homens de letras serviram à casa real como oficiais, representaram os reis portugueses em atos políticos e diplomáticos e exerceram um grande leque de funções na esfera da administração central - políticas, jurídicas, médicas, económicas, administrativas. A presença desses elementos ao lado dos monarcas fez-se sentir desde a fundação do reino, logo desde o reinado de D. Afonso Henriques, coincidindo o corolário deste processo de recrutamento com a chegada de D. Afonso III ao trono, numa política continuada, de forma firme, por D. Dinis. O conjunto de eruditos recenseados junto dos reis portugueses da época fundacional constitui, nessa medida, um interessante estudo de caso para compreender, em parte, em que consistia um círculo áulico, à luz dos valores do século XII e XIII.

Applications of high power microwaves to atmospheric modification and measurement

International Nuclear Information System (INIS)

Benford, J.

1993-01-01

The current state of proposals to use high power microwaves in the atmosphere is reviewed. HPM has been proposed to aid in the conservation of stratospheric ozone by partial breakdown, facilitating chemistry to eliminate chlorine. Another proposal is over-the-horizon radar using a partial breakdown area in the ionosphere. A key to any such effort is rapid diagnosis of the state of the atmosphere before, during and after intervention. Technology requirements of these modification and measurement proposals are reviewed. The elements of an atmospheric modification program are identified and political, economic and ideological factors are discussed

Environmental Science and Technology

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-01

The Program on Environmental Science and Technology comprehends environmental chemistry (water, soil and atmospheric chemistry), clean technologies (desulfurization of diesel and oil, biodegradable polymers and structural modification of polymers, recycling, pyrolysis of dangerous chemicals by molten salt technology), nanotechnology (magnetic nanoparticles, dendrimers, nano biomarkers, catalyzers) and chemical characterization of nuclear fuel and nuclear fuel cycle waste (chemical and isotopic characterization)

Pulsed electric field-assisted modification of pectin from sugar beet pulp.

Science.gov (United States)

Ma, Sen; Wang, Zhong-he

2013-02-15

This current work is concerned with the modification of sugar beet pulp (SBP) pectin assisted by pulsed electric filed (PEF) without solvent. Pectin-arachates with degree of esterification (DE) ranging from 49 to 84 were prepared in one-step modification. The results showed that the DE of pectin derivatives increased significantly with the PEF intensity from 18 to 30 kV cm((1) and total specific energy input from 124 to 345 J mL((1). Evidence of modification of pectin was provided by FT-IR, X-ray diffraction patterns and NMR spectra. Thermogravimetric investigation of modified pectin indicated a higher thermal stability than the untreated one. Results revealed that PEF technology is a promising method for industrial manufacture of pectin derivatives. Copyright © 2012 Elsevier Ltd. All rights reserved.

Alometría y dimorfismo sexual del fémur de Homo sapiens y Homo neanderthalensis en un contexto evolutivo

OpenAIRE

Anaya García, Noelia; Rosas, Antonio; Bastir, Markus; Estalrrich, Almudena; García-Tabernero, Antonio; Huguet, Rosa; Rasilla, Marco de la; Pastor, Francisco

2015-01-01

Comunicación presentada en el XIII Encuentro en Jóvenes Investigadores en Paleontología (XIII EJIP) - XIII Meeting of Early-Stage Researchers in Paleontology (XIII EJIP): Cercedilla, 15 - 18 de Abril de 2015

A new window to an old world: reconstructing the Middle Eocene of Messel for Hessisches Landesmuseum Darmstadt

OpenAIRE

Sanisidro, Óscar; Micklich, Norbert; Sandrock, Oliver

2015-01-01

Comunicación presentada en el XIII Encuentro en Jóvenes Investigadores en Paleontología (XIII EJIP) - XIII Meeting of Early-Stage Researchers in Paleontology (XIII EJIP): Cercedilla, 15 - 18 de Abril de 2015

Sustainable energy planning decision using the intuitionistic fuzzy analytic hierarchy process: choosing energy technology in Malaysia: necessary modifications

Science.gov (United States)

Al-Qudaimi, Abdullah; Kumar, Amit

2018-05-01

Recently, Abdullah and Najib (International Journal of Sustainable Energy 35(4): 360-377, 2016) proposed an intuitionistic fuzzy analytic hierarchy process to deal with uncertainty in decision-making and applied it to establish preference in the sustainable energy planning decision-making of Malaysia. This work may attract the researchers of other countries to choose energy technology for their countries. However, after a deep study of the published paper (International Journal of Sustainable Energy 35(4): 362-377, 2016), it is noticed that the expression used by Abdullah and Najib in Step 6 of their proposed method for evaluating the intuitionistic fuzzy entropy of each aggregate of each row of intuitionistic fuzzy matrix is not valid. Therefore, it is not genuine to use the method proposed by Abdullah and Najib for solving real-life problems. The aim of this paper was to suggest the required necessary modifications for resolving the flaws of the Abdullah and Najib method.

合成革用水性聚氨酯树脂的改性研究进展%New Research Progress in the Modification Technology of Waterborne Polyurethane Resin Used for the Manufacture of Synthetic Leather

Institute of Scientific and Technical Information of China (English)

杨建军; 张建安; 吴庆云; 吴明元

2013-01-01

In this paper, the characteristics of waterborne polyurethane ( WPU) and its research progress of new technologies on modifying WPU resin were introduced. The main problems in the production and application of WPU resin used for the manufacture of synthetic leather were discussed. However, since the hydrophilic group is introduced into the molecules, WPU is weak in water resistance, solvent resistance, water vapor permeability, compatibility and rate of drying, hence the necessity of modifying WPU, such as the acrylate modification, organic silicon modification, organic fluorine modification, vegetable oil modification, epoxy resin modification, nanometer materials modification,and hyperbranched polymer modification,etc. The use of radiation technology, including radiation polymerization, crosslinking and curing, in copolymer latex is reviewed in the paper. The likely future trends of the modification design of WPU resin used for the manufacture of synthetic leather were described.%该文介绍了水性聚氨酯的性能特点以及改性新技术的研究进展.论述了合成革用水性聚氨酯树脂在生产和应用中存在的主要问题,由于分子中引入了亲水基团,水性聚氨酯树脂在耐水性、耐溶剂性、透气透湿性、配伍性和干燥速度等方面表现较差,需要对其进行改性研究,如采用丙烯酸酯改性、有机硅改性、有机氟改性、植物油改性、环氧树脂改性、纳米材料改性和超支化聚合物改性等,并讨论了辐射聚合、交联及固化等辐射技术在共聚物乳液制备上的研究及应用.最后对合成革用水性聚氨酯树脂改性设计的发展前景作了展望.

RESEÑA de : López Villalba, José Miguel. Las finanzas de un concejo castellano: Piedrahíta, siglos xv–xvii. Estudio y documentos. Volumen XIII (1521–1522. Ávila: Ediciones de la Institución Gran Duque de Alba de la Excma. Diputación Provincial de Ávila.

Directory of Open Access Journals (Sweden)

Pedro Luis Lorenzo Cadarso

2015-06-01

Full Text Available RESEÑA de : López Villalba, José Miguel. Las finanzas de un concejo castellano: Piedrahíta, siglos xv–xvii. Estudio y documentos. Volumen XIII (1521–1522. Ávila: Ediciones de la Institución Gran Duque de Alba de la Excma. Diputación Provincial de Ávila.

Epigenetic modifications and diabetic nephropathy

Directory of Open Access Journals (Sweden)

Marpadga A. Reddy

2012-09-01

Full Text Available Diabetic nephropathy (DN is a major complication associated with both type 1 and type 2 diabetes, and a leading cause of end-stage renal disease. Conventional therapeutic strategies are not fully efficacious in the treatment of DN, suggesting an incomplete understanding of the gene regulation mechanisms involved in its pathogenesis. Furthermore, evidence from clinical trials has demonstrated a “metabolic memory” of prior exposure to hyperglycemia that continues to persist despite subsequent glycemic control. This remains a major challenge in the treatment of DN and other vascular complications. Epigenetic mechanisms such as DNA methylation, nucleosomal histone modifications, and noncoding RNAs control gene expression through regulation of chromatin structure and function and post-transcriptional mechanisms without altering the underlying DNA sequence. Emerging evidence indicates that multiple factors involved in the etiology of diabetes can alter epigenetic mechanisms and regulate the susceptibility to diabetes complications. Recent studies have demonstrated the involvement of histone lysine methylation in the regulation of key fibrotic and inflammatory genes related to diabetes complications including DN. Interestingly, histone lysine methylation persisted in vascular cells even after withdrawal from the diabetic milieu, demonstrating a potential role of epigenetic modifications in metabolic memory. Rapid advances in high-throughput technologies in the fields of genomics and epigenomics can lead to the identification of genome-wide alterations in key epigenetic modifications in vascular and renal cells in diabetes. Altogether, these findings can lead to the identification of potential predictive biomarkers and development of novel epigenetic therapies for diabetes and its associated complications.

Enzymatic modification of phospholipids forfunctional applications and human nutrition

DEFF Research Database (Denmark)

Guo, Zheng; Vikbjerg, Anders / Falk; Xu, Xuebing

2005-01-01

analogs based on the latest understanding of pivotal role of phospholipids in manifold biological processes, exploration of remarkable application potentials of phospholipids in meliorating human health, as well as development of new chemical and biotechnological approaches applied to the modification...... design. This will of course provide fundamental bases also for the development of enzymatic technology to produce structured or modified phospholipids....

The application of radiation technology in the field of medical biomaterials

International Nuclear Information System (INIS)

Jin Huanyu; An Yan; Yin Hua

2011-01-01

The radiation technology has been applied extensively in the fields of biological engineering, tissue engineering, medical industry and so on. It also plays an important role in the sterilization and modification of biomaterials. This work reviews the development of irradiation technology and absorbed doses for the sterilization and modification of medical biomaterials. (authors)

Modification of Food Systems by Ultrasound

Directory of Open Access Journals (Sweden)

L. M. Carrillo-Lopez

2017-01-01

Full Text Available This review describes the mechanism, operation, and recent potential applications of ultrasound in various food systems, as well as the physical and chemical effects of ultrasound treatments on the conservation and modification of different groups of food. Acoustic energy has been recognized as an emerging technology with great potential for applications in the food industry. The phenomenon of acoustic cavitation, which modifies the physical, chemical, and functional properties of food, can be used to improve existing processes and to develop new ones. The combination of ultrasonic energy with a sanitizing agent can improve the effect of microbial reduction in foods and, thereby, their quality. Finally, it is concluded that the use of ultrasound in food is a very promising area of research; however, more research is still needed before applying this technology in a wider range of industrial sectors.

Cleaner production technology for the NDT industry

International Nuclear Information System (INIS)

Relunia, Estrella D.; Mateo, Alejandro J.

2001-01-01

This paper discusses te wastes generated from the conduct of nondestructive testing (NDT) techniques and operations like NDT film processing and the systems to reduce water pollution and the film system quality control. Discussions on clean technology production concepts and philosophy is also discussed. A case study on cleaner production technology where a process and equipment modifications and a product substitution were implemented is presented. The equipment modification and product substitution eliminated the use of 1,1,1-trichloroethane in its cleaning operation. (Author)

Advanced oxidation and adsorption modification of dust waste from standard moulding sands

Directory of Open Access Journals (Sweden)

A. Baliński

2010-04-01

Full Text Available The article discusses the process of advanced oxidation (AO with application of ultrasounds and surface modification of the dust waste collected during dry dedusting of processed moulding sands with bentonite binder. A beneficial effect of both AO and adsorption modification of dust waste, when performed with the selected type of polyelectrolyte, on the technological and mechanical properties of moulding sands prepared with an addition of this dust has been stated. In spite of the bentonite content in moulding sand reduced by 43% and replaced with modified dust waste, the mechanical properties, i.e. the compression and tensile strengths, examined on sand specimens have been improved by 10% and 13%, respectively, with no harm to other basic technological sand properties. At the same time, it was also possible to reduce by about 30% the emission rate of the main gaseous component from the BTEX group, i.e. benzene.

Survey of Enabling Technologies for CAPS

Science.gov (United States)

Antol, Jeffrey; Mazanek, Daniel D.; Koons, Robert H.

2005-01-01

The enabling technologies required for the development of a viable Comet/Asteroid Protection System (CAPS) can be divided into two principal areas: detection and deflection/orbit modification. With the proper funding levels, many of the technologies needed to support a CAPS architecture could be achievable within the next 15 to 20 years. In fact, many advanced detection technologies are currently in development for future in-space telescope systems such as the James Webb Space Telescope (JWST), formerly known as the Next Generation Space Telescope. It is anticipated that many of the JWST technologies would be available for application for CAPS detection concepts. Deflection/orbit modification technologies are also currently being studied as part of advanced power and propulsion research. However, many of these technologies, such as extremely high-output power systems, advanced propulsion, heat rejection, and directed energy systems, would likely be farther term in availability than many of the detection technologies. Discussed subsequently is a preliminary examination of the main technologies that have been identified as being essential to providing the element functionality defined during the CAPS conceptual study. The detailed requirements for many of the technology areas are still unknown, and many additional technologies will be identified as future in-depth studies are conducted in this area.

7 CFR 1721.104 - Eligible purposes.

Science.gov (United States)

2010-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF...; (xii) Thermal windows; (xiii) Storm or thermal doors; (xiv) Electric system coordinated customer-owned... including, without limitation: (i) Energy conversion technology; (ii) Electric power system interfaces; (iii...

Effects of surface atomistic modification on mechanical properties of gold nanowires

International Nuclear Information System (INIS)

Sun, Xiao-Yu; Xu, Yuanjie; Wang, Gang-Feng; Gu, Yuantong; Feng, Xi-Qiao

2015-01-01

Highlights: • Molecular dynamics simulations of surface modification effect of Au nanowires. • Surface modification can greatly affect the mechanical properties of nanowires. • Core–shell model is used to elucidate the effect of residual surface stress. - Abstract: Modulation of the physical and mechanical properties of nanowires is a challenging issue for their technological applications. In this paper, we investigate the effects of surface modification on the mechanical properties of gold nanowires by performing molecular dynamics simulations. It is found that by modifying a small density of silver atoms to the surface of a gold nanowire, the residual surface stress state can be altered, rendering a great improvement of its plastic yield strength. This finding is in good agreement with experimental measurements. The underlying physical mechanisms are analyzed by a core–shell nanowire model. The results are helpful for the design and optimization of advanced nanomaterial with superior mechanical properties

Methods of preparation and modification of advanced zero-valent iron nanoparticles, their properties and application in water treatment technologies

Science.gov (United States)

Filip, Jan; Kašlík, Josef; Medřík, Ivo; Petala, Eleni; Zbořil, Radek; Slunský, Jan; Černík, Miroslav; Stavělová, Monika

2014-05-01

Zero-valent iron nanoparticles are commonly used in modern water treatment technologies. Compared to conventionally-used macroscopic iron or iron microparticles, the using of nanoparticles has the advantages given mainly by their generally large specific surface area (it drives their high reactivity and/or sorption capacity), small dimensions (it allows their migration e.g. in ground water), and particular physical and chemical properties. Following the applications of zero-valent iron particles in various pilot tests, there arose several critical suggestions for improvements of used nanomaterials and for development of new generation of reactive nanomaterials. In the presentation, the methods of zero-valent iron nanoparticles synthesis will be summarized with a special attention paid to the thermally-induced solid-state reaction allowing preparation of zero-valent iron nanoparticles in an industrial scale. Moreover, the method of thermal reduction of iron-oxide precursors enables to finely tune the critical parameters (mainly particle size and morphology, specific surface area, surface chemistry of nanoparticles etc.) of resulting zero-valet iron nanoparticles. The most important trends of advanced nanoparticles development will be discussed: (i) surface modification of nanomaterilas, (ii) development of nanocomposites and (iii) development of materials for combined reductive-sorption technologies. Laboratory testing of zero-valent iron nanoparticles reactivity and migration will be presented and compared with the field observations: the advanced zero-valent iron nanoparticles were used for groundwater treatment at the locality contaminated by chlorinated hydrocarbons (VC, DCE, TCE and PCE) and reacted nanoparticles were extracted from the sediments for their fate assessment. The authors gratefully acknowledge the support by the Technology Agency of the Czech Republic "Competence Centres" (project No. TE01020218) and the EU FP7 (project NANOREM).

Ammonia modification for flotation separation of polycarbonate and polystyrene waste plastics.

Science.gov (United States)

Wang, Chong-Qing; Wang, Hui; Gu, Guo-Hua; Lin, Qing-Quan; Zhang, Ling-Ling; Huang, Luo-Luo; Zhao, Jun-Yao

2016-05-01

A promising method, ammonia modification, was developed for flotation separation of polycarbonate (PC) and polystyrene (PS) waste plastics. Ammonia modification has little effect on flotation behavior of PS, while it changes significantly that of PC. The PC recovery in the floated product drops from 100% to 3.17% when modification time is 13min and then rises to 100% after longer modification. The mechanism of ammonia modification was studied by contact angle, and Fourier transform infrared (FT-IR) and X-ray photoelectron spectroscopy (XPS) measurements. Contact angle of PC indicates the decline of PC recovery in the floated product is ascribed to an increase in surface wettability. FT-IR and XPS spectra suggest that ammonia modification causes chemical reactions occurred on PC surface. Flotation behavior of ammonia-modified PC and PS was investigated with respect to flotation time, frother concentration and particle sizes. Flotation separation of PC and PS waste plastics was conducted based on the flotation behavior of single plastic. PC and PS mixtures with different particle sizes are separated efficiently, implying that the technology possesses superior applicability to particle sizes of plastics. The purity of PS and PC is up to 99.53% and 98.21%, respectively, and the recovery of PS and PC is larger than 92.06%. A reliable, cheap and effective process is proposed for separation of PC and PS waste plastics. Copyright © 2016 Elsevier Ltd. All rights reserved.

Dynamic Binary Modification Tools, Techniques and Applications

CERN Document Server

Hazelwood, Kim

2011-01-01

Dynamic binary modification tools form a software layer between a running application and the underlying operating system, providing the powerful opportunity to inspect and potentially modify every user-level guest application instruction that executes. Toolkits built upon this technology have enabled computer architects to build powerful simulators and emulators for design-space exploration, compiler writers to analyze and debug the code generated by their compilers, software developers to fully explore the features, bottlenecks, and performance of their software, and even end-users to extend

Optimization of Squeeze Parameters and Modification of AlSi7Mg Alloy

Directory of Open Access Journals (Sweden)

Zyska A.

2013-06-01

Full Text Available The paper present the examination results concerning mechanical properties of castings made of AlSi7MG alloy in correlation both with the most significant squeeze casting parameters and with the modification treatment. Experiments were planned and held according to the 23 factorial design. The regression equations describing the influence of the squeeze pressure, the mould temperature, and the quantity of strontium modifier on the strength and elongation of the examined alloy were obtained. It was found that the main factor controlling the strength increase is the squeeze pressure, while the plasticity (A5 of the alloy is affected most advantageously by modification. The application of modification treatment in squeeze casting technology enables for production of the slab-type castings made of AlSi7Mg alloy exhibiting strength at the level of 230 MPa and elongation exceeding 14%.

Proposal of Modification Strategy of NC Program in the Virtual Manufacturing Environment

Science.gov (United States)

Narita, Hirohisa; Chen, Lian-Yi; Fujimoto, Hideo; Shirase, Keiichi; Arai, Eiji

Virtual manufacturing will be a key technology in process planning, because there are no evaluation tools for cutting conditions. Therefore, virtual machining simulator (VMSim), which can predict end milling processes, has been developed. The modification strategy of NC program using VMSim is proposed in this paper.

Verslag: �Society of Biblical Literature (SBL 1989 International Meeting�, 6 tot 9 Augustus 1989 te Kopenhagen, Denemarke; en �The XIII Congress of the International Organization for the study of the Old Testament (IOSOT�, 27 Augustus tot 1 September 19

Directory of Open Access Journals (Sweden)

W. S. Prinsloo

1990-08-01

Full Text Available "Society of Biblical Literature (SBL 1989 International Meeting". 6-9 August 1989, Copenhagen, Denmark; and "The XIII Congress of the International Organization for the study of the Old Testament (IOSOT". 27 August to 1 September 1989, Leuven, Belgium This article is a report on the IOSOT Congress at Leuven. Belgium, and the SBL Congress in Copenhagen, Denmark. It contains brief summaries of the more important papers read and indicates some of the more significant trends which emerged at the two congresses.

Seaweed Hydrocolloid Production: An Update on Enzyme Assisted Extraction and Modification Technologies

DEFF Research Database (Denmark)

Rhein-Knudsen, Nanna; Ale, Marcel Tutor; Meyer, Anne S.

2015-01-01

Agar, alginate, and carrageenans are high-value seaweed hydrocolloids, which are used as gelation and thickening agents in different food, pharmaceutical, and biotechnological applications. The annual global production of these hydrocolloids has recently reached 100,000 tons with a gross market......-made modifications of the hydrocolloids to obtain specific functionalities. This review provides an update of the detailed structural features of κ-, ι-, λ-carrageenans, agars, and alginate, and a thorough discussion of enzyme assisted extraction and processing techniques for these hydrocolloids....

75 FR 22499 - Establishing an Interagency Task Force on Federal Contracting Opportunities for Small Businesses

Science.gov (United States)

2010-04-29

... the Heads of Executive Departments and Agencies The Federal Government is the world's largest... to small businesses, the Congress also established Government-wide contracting goals for... of the Office of Science and Technology Policy; (xiii) the Director of the Domestic Policy Council...

Photon technology. Hard photon technology; Photon technology. Hard photon gijutsu

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-03-01

For the application of photon to industrial technologies, in particular, a hard photon technology was surveyed which uses photon beams of 0.1-200nm in wavelength. Its features such as selective atom reaction, dense inner shell excitation and spacial high resolution by quantum energy are expected to provide innovative techniques for various field such as fine machining, material synthesis and advanced inspection technology. This wavelength region has been hardly utilized for industrial fields because of poor development of suitable photon sources and optical devices. The developmental meaning, usable time and issue of a hard photon reduction lithography were surveyed as lithography in ultra-fine region below 0.1{mu}m. On hard photon analysis/evaluation technology, the industrial use of analysis, measurement and evaluation technologies by micro-beam was viewed, and optimum photon sources and optical systems were surveyed. Prediction of surface and surface layer modification by inner shell excitation, the future trend of this process and development of a vacuum ultraviolet light source were also surveyed. 383 refs., 153 figs., 17 tabs.

Modification of GNPS environment radiation monitoring network system

International Nuclear Information System (INIS)

Jiang Lili; Cao Chunsheng

1999-01-01

GNPS Environment Radiation Continuous Monitoring System (KRS), the only real time on-line system of site radiation monitoring, was put into service in 1993 prior to the first loading the the plant. It is revealed through several years of operation that this system has some deficiencies such as inadequate real time monitoring means, no figure and diagram display function on the central computer, high failures, frequent failure warning signals, thus making the availability of the system at a low level. In recent years, with the rapid development of computer network technology and increasingly strict requirements on the NPP environment protection raised by the government and public, KRS modification had become necessary and urgent. In 1996, GNPS carried out modification work on the measuring geometry condition of γ radiation monitoring sub-station and lightening protection. To enhance the functions of real time monitoring and data auto-processing, further modification of the system was made in 1998, including the update of the software and hardware of KRS central processor, set-up of system computer local network and database. In this way, the system availability and monitoring quality are greatly improved and effective monitoring and analysis means are provided for gaseous release during normal operation and under accident condition

Modifications to HFEF/S for IFR fuel cycle demonstration

International Nuclear Information System (INIS)

Lineberry, M.J.; Phipps, R.D.; Forrester, R.J.; Carnes, M.D.; Rigg, R.H.

1988-01-01

Modifications have begun to the Hot Fuel Examination Facility-South (HFEF/S) in order to demonstrate the technology of the integral fast reactor (IFR) fuel cycle. This paper describes the status of the modifications to the facility and briefly reviews the status of the development of the process equipment. The HFEF/S was the demonstration facility for the early Experimental Breeder Reactor II (EBR-II) melt refining/injection-casting fuel cycle. Then called the Fuel Cycle Facility, ∼400 EBR-II fuel assemblies were recycled in the two hot cells of the facility during the 1964-69 period. Since then it has been utilized as a fuels examination facility. The objective of the IFR fuel cycle program is to upgrade HFEF/S to current standards, install new process equipment, and demonstrate the commercial feasibility of the IFR pyroprocess fuel cycle

Evaluation of technology modifications required to apply clean coal technologies in Russian utilities. Final report

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-12-01

The report describes the following: overview of the Russian power industry; electric power equipment of Russia; power industry development forecast for Russia; clean coal technology demonstration program of the US Department of Energy; reduction of coal TPS (thermal power station) environmental impacts in Russia; and base options of advanced coal thermal power plants. Terms of the application of clean coal technology at Russian TPS are discussed in the Conclusions.

Embedding technology into inter-professional best practices in home safety evaluation.

Science.gov (United States)

Burns, Suzanne Perea; Pickens, Noralyn Davel

2017-08-01

To explore inter-professional home evaluators' perspectives and needs for building useful and acceptable decision-support tools for the field of home modifications. Twenty semi-structured interviews were conducted with a range of home modification professionals from different regions of the United States. The interview transcripts were analyzed with a qualitative, descriptive, perspective approach. Technology supports current best practice and has potential to inform decision making through features that could enhance home evaluation processes, quality, efficiency and inter-professional communication. Technological advances with app design have created numerous opportunities for the field of home modifications. Integrating technology and inter-professional best practices will improve home safety evaluation and intervention development to meet client-centred and societal needs. Implications for rehabilitation Understanding home evaluators technology needs for home safety evaluations contributes to the development of app-based assessments. Integrating inter-professional perspectives of best practice and technological needs in an app for home assessments improves processes. Novice and expert home evaluators would benefit from decision support systems embedded in app-based assessments. Adoption of app-based assessment would improve efficiency while remaining client-centred.

Technical Modification Within the Healthcare Industry: Improving Both the Efficacy of the National Drug Code Carrier and the Accessibility of Electronic Health Records to Reduce Adverse Drug Events

Science.gov (United States)

2013-06-01

with an EHR .................................................. 97 C. SWOT ANALYSIS OF USING QR CODES WITH THE NDC AND WITH EHRS...96 Figure 41. SWOT analysis ................................................................................... 99 xiii LIST OF...having an EHR provides a more robust overall solution. C. SWOT ANALYSIS OF USING QR CODES WITH THE NDC AND WITH EHRS In order to conduct an

78 FR 40619 - Combating Wildlife Trafficking

Science.gov (United States)

2013-07-05

... derivative parts and products (together known as ``wildlife trafficking'') represent an international crisis... trafficking in accordance with the following objectives: (a) in appropriate cases, the United States shall... Quality; (xii) the Office of Science and Technology Policy; (xiii) the Office of Management and Budget...

Electron beam induced modification of grafted polyamides

International Nuclear Information System (INIS)

Timus, D.M.; Brasoveanu, M.M.; Bradley, D.A.; Popov, A.M.

1998-01-01

It is well known that irradiation, when applied on its own or in combination with other physical and chemical treatments, can manifest in radiation damage to materials. Radiation processing technology focuses upon producing favourable modification of materials through use of relatively high dose and dose rates. Current interest is in modifying the thermal and electrical properties of textured polymers in an effort to improve safety and wear comfort of clothing. No less important is the production of textiles which are safe to use, both in homes and offices. Present investigations provide additional data in support of findings which show that polyamides, a particular class of textured polymer, are amenable to radiation processing. Accelerated electron beam irradiation of sheets of polyamide fibre results in induced grafting of acrylic and methacrylic acids. The degree of grafting is critically dependent upon irradiation dose and the extent of monomers dilution. Of particular importance is the high correlation which is found between degree of grafting and a decrease in the softening rate of the modified polyamide. A systematic modification of electrical conductivity is also observed. (author)

Castillos, poder feudal y reorganización espacial en la Transierra madrileña (siglos XII-XIII

Directory of Open Access Journals (Sweden)

Iñaki Martín Viso

2000-01-01

Full Text Available Algunos castillos de la Transierra madrileña en los siglos xii y xiii son herederos de los husün musulmanes, pero se convierten en esa época en centros de poder señorial sobre unas débiles comunidades. No obstante, sólo su transformación en concejos permitirá la supervivencia de algunos de ellos, aunque se observa también un desplazamiento del habitat hacia el llano, resultado de la formación de un nuevo sistema productivo basado en la agricultura cerealfstica y la propiedad feudal, por lo que el papel de los castillos es limitado. En las zonas serranas su relevancia es aún menor y nunca estructuraron el paisaje, labor que ejercieran los sexmos de la Tierra de Segovia.Some castles of the Madrid's Transierra in the xii"" and xiif" centuries are inheritors of the muslim husün, but they viere converted during this age in centres of a lordship power which was imposed to the weak communities. However, only some of them could survive through their conversión In town counciis (concejos, although there is also an habitat's displacement to the plain, that is the result of the new producing system based on the grain agrículture and the feudal property, so the role of the castles was reduced. In the mountain áreas the landscape was never structured by castles, but by the rural distrícts (sexmos ofthe Segovia's Land.

The roles of weather modification technology in mitigation of the peat fires during a period of dry season in Bengkalis, Indonesia

Science.gov (United States)

Sandhyavitri, A.; Perdana, M. A.; Sutikno, S.; Widodo, F. H.

2018-02-01

The annual peat fire disasters have suffered human life, deteriorated peat land ecosystems, and caused severe economic losses in Indonesia, Malaysia, Brunei, and Singapore during a period of 2014-2016. The objective of this study is to investigate to what extent the weather modification technology (WMT) may play its roles in increasing the precipitation rates in order to mitigate the peat fires disaster in Bengkalis, Riau Province, Indonesia. The study obtained the precipitation rates data from the tropical rainfall measuring mission (TRMM) satellite during the period of 2014, 2015 and 2016. The data then statistically analyzed using the Grads software package. While the process of WMT at the designated research location was evaluated together between the Artificial Rain Unit of BPPT (Agency for the Assessment and Application Technology), and the Engineering Faculty, University of Riau, 2016. The research showed that the WMT increased the rainfall rates during the dry season within the study area by 8% (520.7 mm to 557 mm) in the 3 months period (July 14 -October 6, 2016), and reducing significantly hotspots by 88.6% from 6.725 in 2014 to 770 in 2016. Hence, it confirmed that the application of technical WMT procedures may increase precipitation rates and reduce the number of hot spots in Bengkalis.

Procès inquisitorial contra el castellà d'Amposta Fra Pedro Roiç de Moros a la cúria pontificia del papa Benet XIII (I414-1418

Directory of Open Access Journals (Sweden)

Alanyà i Roig, Josep

2002-06-01

Full Text Available The Arxiu de la Corona d'Aragó in Barcelona houses the original commital proceedings instituted by a court of cardinals set up by pope Benedict XIII in the year 1414 and teh trial itself of the lord of Amposta, Fra Pedro Roiç de Moros, knight of the Order of St. John of Jerusalem, who had been charged with indictable offences—concubinage, robbery, housing apostates, oath breaking and counterfeiting money, mismanagement of the Castlery's assets, excesses against his vassals, wasteful use of assets, dereliction and property abandonment— of which he was found guilty, and thereafter sentenced to losing the dignity of his lordship. Roiç de Moros appealed to the Council of Constance as well as to pope Martin V. It would be to no avail. Roiç de Moros paid a very high price for choosing to support count Jaume d'Urgell and deciding to oppose Ferran dAntequera and the policies of pope Benedict XIII. The follow up and analysis of the court´s records are very interesting for their human variety and interesting informations about fortresses, houses, barns, treaures and services there were in different locations of the Castlery of Amposta, such as Batea, Gandesa, Miravet, Ulldecona, Ascó and other towns and villages along the Ribera d´Ebre. The whole criminal prosecution bears a very peculiar historic interest mainly because the protagonists, the court procedures, and their causes are the link between the Interregnum in the Aragonese Crown and the fìnal days of the Western Schism.

A l'Arxiu de la Corona d'Aragó de Barcelona es conserva el procés original instruït per un tribunal de cardenals creat pel papa Benet XIII l'any 1414 per jutjar el Castella d'Amposta, l'hospitaler Fra Pedro Roiç de Moros, acusat de crims greus —concubinat, bandositats, recepció d’apòstates, perjuri i fabricació de moneda falsa, mala administració dels bens de la Castellania, comissió d'excessos contra els seus vassalls, dilapidado de bens i abando

A novel Sarcocystis neurona genotype XIII is associated with severe encephalitis in an unexpectedly broad range of marine mammals from the northeastern Pacific Ocean.

Science.gov (United States)

Barbosa, Lorraine; Johnson, Christine K; Lambourn, Dyanna M; Gibson, Amanda K; Haman, Katherine H; Huggins, Jessica L; Sweeny, Amy R; Sundar, Natarajan; Raverty, Stephen A; Grigg, Michael E

2015-08-01

Sarcocystis neurona is an important cause of protozoal encephalitis among marine mammals in the northeastern Pacific Ocean. To characterise the genetic type of S. neurona in this region, samples from 227 stranded marine mammals, most with clinical or pathological evidence of protozoal disease, were tested for the presence of coccidian parasites using a nested PCR assay. The frequency of S. neurona infection was 60% (136/227) among pinnipeds and cetaceans, including seven marine mammal species not previously known to be susceptible to infection by this parasite. Eight S. neurona fetal infections identified this coccidian parasite as capable of being transmitted transplacentally. Thirty-seven S. neurona-positive samples were multilocus sequence genotyped using three genetic markers: SnSAG1-5-6, SnSAG3 and SnSAG4. A novel genotype, referred to as Type XIII within the S. neurona population genetic structure, has emerged recently in the northeastern Pacific Ocean and is significantly associated with an increased severity of protozoal encephalitis and mortality among multiple stranded marine mammal species. Published by Elsevier Ltd.

The Effects of Technological Modifications on the Fermentation of ...

African Journals Online (AJOL)

Journal of Food Technology in Africa. Journal Home · ABOUT · Advanced Search · Current Issue · Archives · Journal Home > Vol 9, No 1 (2004) >. Log in or Register to get access to full text downloads.

A new technology to overcome the limits of HCCI engine through fuel modification

International Nuclear Information System (INIS)

Bahng, GunWoong; Jang, Dongsoon; Kim, Youngtae; Shin, Misoo

2016-01-01

Highlights: • Problems of HCCI engine can be overcome by adopting fuel modification. • Gasoline vapor with HHO gas showed drastic improvement of fuel efficiency. • Performance of single cylinder engine shows fuel efficiency more than double. - Abstract: The energy efficiency of internal combustion engine reached to about 30% only recently. To increase the efficiency, homogeneous charge compression ignition (HCCI) has been proposed, however, there is no available commercial engine yet. The main problem lies in the delayed heating rate in spite of fast reaction of homogeneous charged state of HCCI with excess air. To overcome this difficulty, a modification of fuel by vaporization of liquid gasoline with water electrolysis gas and air was adopted in order to warrant the fast and high temperature rise. Experiments were carried out with single cylinder engines supplied from the four different manufacturers. Experimental results show that fuel consumption was decreased by more than 50% compared to the case of supplying liquid fuel. It is believed it was due to the combined effects of the high and fast heating potential of water electrolysis gas together with the efficient turbulence mixing effect of vaporized fuel with excess air. By this method, the drawbacks caused by lean burn in the HCCI engine such as small power range can be overcome.

Surface Modification of Sputtered Ga.5In.5Sb Thin Films ISHU ...

African Journals Online (AJOL)

MICHAEL

IR detectors useful for fiber optic communication. Since the efficiency of detector depends very much on the surface properties of the substrate material, improvement of substrate surfaces is a challenging task in device technology. Reports on the improved electrical properties of GaAs and InP surfaces by. Ru3+ modification ...

Surface modification and characterization for dispersion stability of inorganic nanometer-scaled particles in liquid media

International Nuclear Information System (INIS)

Kamiya, Hidehiro; Iijima, Motoyuki

2010-01-01

Inorganic nanoparticles are indispensable for science and technology as materials, pigments and cosmetics products. Improving the dispersion stability of nanoparticles in various liquids is essential for those applications. In this review, we discuss why it is difficult to control the stability of nanoparticles in liquids. We also overview the role of surface interaction between nanoparticles in their dispersion and characterization, e.g. by colloid probe atomic force microscopy (CP-AFM). Two types of surface modification concepts, post-synthesis and in situ modification, were investigated in many previous studies. Here, we focus on post-synthesis modification using adsorption of various kinds of polymer dispersants and surfactants on the particle surface, as well as surface chemical reactions of silane coupling agents. We discuss CP-AFM as a technique to analyze the surface interaction between nanoparticles and the effect of surface modification on the nanoparticle dispersion in liquids. (topical review)

Surface modification and characterization for dispersion stability of inorganic nanometer-scaled particles in liquid media

Directory of Open Access Journals (Sweden)

Hidehiro Kamiya and Motoyuki Iijima

2010-01-01

Full Text Available Inorganic nanoparticles are indispensable for science and technology as materials, pigments and cosmetics products. Improving the dispersion stability of nanoparticles in various liquids is essential for those applications. In this review, we discuss why it is difficult to control the stability of nanoparticles in liquids. We also overview the role of surface interaction between nanoparticles in their dispersion and characterization, e.g. by colloid probe atomic force microscopy (CP-AFM. Two types of surface modification concepts, post-synthesis and in situ modification, were investigated in many previous studies. Here, we focus on post-synthesis modification using adsorption of various kinds of polymer dispersants and surfactants on the particle surface, as well as surface chemical reactions of silane coupling agents. We discuss CP-AFM as a technique to analyze the surface interaction between nanoparticles and the effect of surface modification on the nanoparticle dispersion in liquids.

Assessment of modification level of hypoeutectic Al -Si alloys by pattern recognition of cooling curves

Directory of Open Access Journals (Sweden)

CHEN Xiang

2005-11-01

Full Text Available Most evaluations of modification level are done according to a specific scale based on an merican Foundry Society (AFS standard wall chart as qualitative analysis in Al-Si casting production currently. This method is quite dependent on human experience when making comparisons of the microstructure with the standard chart. And the structures depicted in the AFS chart do not always resemble those seen in actual Al-Si castings. Therefore, this ualitativeanalysis procedure is subjective and can introduce human-caused errors into comparative metallographic analyses. A quantization parameter of the modification level was introduced by setting up the relationship between mean area weighted shape factor of eutectic silicon phase and the modification level using image analysis technology. In order to evaluate the modification level, a new method called "intelligent evaluating of melt quality by pattern recognition of hermal analysis cooling curves" has also been introduced. The results show that silicon modification level can be precisely assessed by comparison of the cooling curve of the melt to be evaluated with the one most similar to it in a database.

Modifications to POISSON

International Nuclear Information System (INIS)

Harwood, L.H.

1981-01-01

At MSU we have used the POISSON family of programs extensively for magnetic field calculations. In the presently super-saturated computer situation, reducing the run time for the program is imperative. Thus, a series of modifications have been made to POISSON to speed up convergence. Two of the modifications aim at having the first guess solution as close as possible to the final solution. The other two aim at increasing the convergence rate. In this discussion, a working knowledge of POISSON is assumed. The amount of new code and expected time saving for each modification is discussed

Surface modification of materials by ion implantations for industrial and medical applications. Final report of a co-ordinated research project

International Nuclear Information System (INIS)

2000-07-01

The objectives of the Co-ordinated Research Project on Modification of Materials by Ion Treatment for Industrial Applications were to develop economically acceptable surface modification techniques leading to thick treated layers, to predict ion beam mixing and impurity atom migration during and after implantation, and to evaluate the tribological post-implantation properties and performance of treated components. This TECDOC summarises the current status and prospects in surface modification by ion implantation methodology and technology, providing new information in basic and applied research

Surface modification of materials by ion implantations for industrial and medical applications. Final report of a co-ordinated research project

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-07-01

The objectives of the Co-ordinated Research Project on Modification of Materials by Ion Treatment for Industrial Applications were to develop economically acceptable surface modification techniques leading to thick treated layers, to predict ion beam mixing and impurity atom migration during and after implantation, and to evaluate the tribological post-implantation properties and performance of treated components. This TECDOC summarises the current status and prospects in surface modification by ion implantation methodology and technology, providing new information in basic and applied research.

CAR models: next-generation CAR modifications for enhanced T-cell function

Directory of Open Access Journals (Sweden)

Daniel Abate-Daga

2016-01-01

Full Text Available T cells genetically targeted with a chimeric antigen receptor (CAR to B-cell malignancies have demonstrated tremendous clinical outcomes. With the proof in principle for CAR T cells as a therapy for B-cell malignancies being established, current and future research is being focused on adapting CAR technology to other cancers, as well as enhancing its efficacy and/or safety. The modular nature of the CAR, extracellular antigen-binding domain fused to a transmembrane domain and intracellular T-cell signaling domains, allows for optimization by replacement of the various components. These modifications are creating a whole new class of therapeutic CARs. In this review, we discuss the recent major advances in CAR design and how these modifications will impact its clinical application.

Caprine Butchery and Bone Modification Templates: A step towards standardisation

Directory of Open Access Journals (Sweden)

Peter Popkin

2005-03-01

Full Text Available Widely accepted zooarchaeological procedure for recording butchery marks and other types of bone modification involves two processes: Drawing the bone showing the exact location and orientation of the modification and recording all of the information about the bone and its modification into an electronic database. No recording templates have ever been published, however, resulting in individual zooarchaeologists repeating the effort of developing their own templates or drawings for each bone in an assemblage showing a modification. Both of these tasks are time consuming and lead to inconsistencies in recording and quantification methods. To help alleviate this problem a series of caprine (sheep and goat bone templates have been created. These templates show every bone in a goat skeleton, apart from the skull, from six views at life-size when printed on A4 paper. They have intentionally been produced with a minimum of detail (without shading or stippling etc. so that the recorded butchery marks and bone modifications will be clearly visible. Because the skeletal morphology of sheep and goats is so similar these templates may be used interchangeably for either species. They may also be used for many other artiodactyl species such as cattle and deer as no scale has been indicated. The study of butchery marks and bone modification has the potential to provide zooarchaeologists with information about taphonomy, site formation processes, burial/ritual practices, human behaviour, ancient technologies and possibly ethnicity amongst other things, but only if the recording of these bone modifications is undertaken in a standardised fashion across the field. While much effort has been directed towards standardising the recognition and classification of various bone modifications, the recording of these modifications regularly occurs in various ways. Using standardised recording templates will save valuable time and help to alleviate problems of data

Plant gene technology: social considerations

African Journals Online (AJOL)

Administrator

The genetic modification of plants by gene technology is of immense potential benefits, but there may be possible risks. ... As a new endeavour, however, people have a mixed ... reality by gene biotechnology (Watson, 1997). Industrial ...

Epigenetics and assisted reproductive technologies

DEFF Research Database (Denmark)

Pinborg, Anja; Loft, Anne; Romundstad, Liv Bente

2016-01-01

Epigenetic modification controls gene activity without changes in the DNA sequence. The genome undergoes several phases of epigenetic programming during gametogenesis and early embryo development coinciding with assisted reproductive technologies (ART) treatments. Imprinting disorders have been...

Technical modifications and management innovations in exporting nuclear reactor projects

International Nuclear Information System (INIS)

Mao Xiaoming; Qin Xijiu; Ding Hu; Xue Zhaoqun; Wen Shengjun

2009-01-01

As a main channel for the foreign economic cooperation of China nuclear industry, China Zhongyuan Engineering Corporation (CZEC) has been constantly engaged in technical modifications and management innovations in its exporting nuclear reactor projects. In the implementation of heavy water research reactor contract in Algeria, CZEC had established a complete and adequate design standards system in compliance with the international standards, and made significant modifications to the reference reactor in the aspects of reactor power and reactor safety, solved quite some technical issues which-affected the reactor technical performance. The modifications and improvements enabled the technical parameters, safety features, reactor multipurpose application to attain to the advanced level in the world. In the 300 MWe PWR NPPs in Pakistan, safety features had been updated in line with upgrading regulatory requisites. The design philosophy and technology application demonstrated CZEC' s creation and innovation on basis of constant safety enhancement of nuclear power projects. Efforts had also been made by CZEC' s creation and innovation on basis of constant safety enhancement of nuclear power projects. Efforts had also been made by CZEC in promoting China made equipment items and components exportation. (authors)

Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A.

Science.gov (United States)

Beckers, Cora M L; Simpson, Kingsley R; Griffin, Kathryn J; Brown, Jane M; Cheah, Lih T; Smith, Kerrie A; Vacher, Jean; Cordell, Paul A; Kearney, Mark T; Grant, Peter J; Pease, Richard J

2017-08-01

To establish the cellular source of plasma factor (F)XIII-A. A novel mouse floxed for the F13a1 gene, FXIII-A flox/flox (Flox), was crossed with myeloid- and platelet-cre-expressing mice, and cellular FXIII-A mRNA expression and plasma and platelet FXIII-A levels were measured. The platelet factor 4-cre.Flox cross abolished platelet FXIII-A and reduced plasma FXIII-A to 23±3% ( P cre on plasma FXIII-A was exerted outside of the megakaryocyte lineage because plasma FXIII-A was not reduced in the Mpl -/- mouse, despite marked thrombocytopenia. In support of this, platelet factor 4-cre depleted FXIII-A mRNA in brain, aorta, and heart of floxed mice, where FXIII-A pos cells were identified as macrophages as they costained with CD163. In the integrin αM-cre.Flox and the double copy lysozyme 2-cre.cre.Flox crosses, plasma FXIII-A was reduced to, respectively, 75±5% ( P =0.003) and 30±7% ( P <0.001), with no change in FXIII-A content per platelet, further consistent with a macrophage origin of plasma FXIII-A. The change in plasma FXIII-A levels across the various mouse genotypes mirrored the change in FXIII-A mRNA expression in aorta. Bone marrow transplantation of FXIII-A +/+ bone marrow into FXIII-A -/- mice both restored plasma FXIII-A to normal levels and replaced aortic and cardiac FXIII-A mRNA, while its transplantation into FXIII-A +/+ mice did not increase plasma FXIII-A levels, suggesting that a limited population of niches exists that support FXIII-A-releasing cells. This work suggests that resident macrophages maintain plasma FXIII-A and exclude the platelet lineage as a major contributor. © 2017 The Authors.

Research trends in biomimetic medical materials for tissue engineering: 3D bioprinting, surface modification, nano/micro-technology and clinical aspects in tissue engineering of cartilage and bone.

Science.gov (United States)

Chen, Cen; Bang, Sumi; Cho, Younghak; Lee, Sahnghoon; Lee, Inseop; Zhang, ShengMin; Noh, Insup

2016-01-01

This review discusses about biomimetic medical materials for tissue engineering of bone and cartilage, after previous scientific commentary of the invitation-based, Korea-China joint symposium on biomimetic medical materials, which was held in Seoul, Korea, from October 22 to 26, 2015. The contents of this review were evolved from the presentations of that symposium. Four topics of biomimetic medical materials were discussed from different research groups here: 1) 3D bioprinting medical materials, 2) nano/micro-technology, 3) surface modification of biomaterials for their interactions with cells and 4) clinical aspects of biomaterials for cartilage focusing on cells, scaffolds and cytokines.

The International Scientific-Practical Conference XIII Faizkhanov Readings “The Heritage of the Golden Horde in the Nationhood and Cultural Traditions of the Peoples of Eurasia” (St. Petersburg, May 4–6, 2016

Directory of Open Access Journals (Sweden)

R.Yu. Pochekaev

2017-03-01

Full Text Available XIII Faizkhanov Readings have been held in St. Petersburg on May 4–6, 2016. This year the conference was devoted to the Golden Horde and its heritage in Eurasia on occasion of the 750 years from foundation of this state. The conference was organized by the Spiritual Administration of Moslems of the Russian Federation, State Hermitage, Moscow State University, St. Petersburg State University, Institute of Oriental Studies, Institute of Oriental Manuscripts and others. There were two plenary sessions and four sections with about 100 speakers from different regions of Russia as well as from Finland, France, Kazakhstan, Ukraine, Uzbekistan. Most part of presentations caused questions and debates. The proceeding of the conference is to be published this year.

Modifications to the HIPAA Privacy, Security, Enforcement, and Breach Notification rules under the Health Information Technology for Economic and Clinical Health Act and the Genetic Information Nondiscrimination Act; other modifications to the HIPAA rules.

Science.gov (United States)

2013-01-25

The Department of Health and Human Services (HHS or ``the Department'') is issuing this final rule to: Modify the Health Insurance Portability and Accountability Act (HIPAA) Privacy, Security, and Enforcement Rules to implement statutory amendments under the Health Information Technology for Economic and Clinical Health Act (``the HITECH Act'' or ``the Act'') to strengthen the privacy and security protection for individuals' health information; modify the rule for Breach Notification for Unsecured Protected Health Information (Breach Notification Rule) under the HITECH Act to address public comment received on the interim final rule; modify the HIPAA Privacy Rule to strengthen the privacy protections for genetic information by implementing section 105 of Title I of the Genetic Information Nondiscrimination Act of 2008 (GINA); and make certain other modifications to the HIPAA Privacy, Security, Breach Notification, and Enforcement Rules (the HIPAA Rules) to improve their workability and effectiveness and to increase flexibility for and decrease burden on the regulated entities.

Come ti leggo un palinsesto, e altre storie dal passato

OpenAIRE

Salerno, Emanuele

2016-01-01

This lecture tells the story of an important medieval palimpsest containing several treatises by Archimedes of Syracuse, hidden under a XIII-century liturgical text. A private project succeeded in the physical restoration of this document and in its study through noninvasive technologies. This is an example of how technology can be exploited for the study and safeguard of our cultural heritage, and gives us the opportunity to show how physical and information technologies can both improve the...

Factors Causing Delay of Modification Projects at Koeberg Nuclear Power Station

International Nuclear Information System (INIS)

Ntoyanto, S.

2017-01-01

Modification project delays could lead to: disrupting the maintenance shutdown (outage) projects' schedule, affecting electricity capacity of the national grid., possible load-shedding restricting electricity supply to domestic, commercial, and industrial consumers; and detrimental consequences to the country's economic activities. To address proficiency of a project manager by improving: Understanding of the organizational processes, High-level technical knowledge of a nuclear power plant technology

Esclavos musulmanes en los hospitales de cautivos de la Orden Militar de Santiago (siglos XII y XIII

Directory of Open Access Journals (Sweden)

Echevarría Arsuaga, Ana

2007-12-01

Full Text Available Military Orders had slave manpower in their lands since their foundation. However, the hospitals for ransoming captives owned by the Order of Santiago are the best example of how slavery worked in the kingdom of Leon-Castile during the twelfth and thirteenth centuries. These houses had enough room to provide lodging for captives while ransoms were being negotiated. They also helped to redistribute those Muslims who, lacking this possibility, became slaves of the order itself, or were sold in the slave markets of the kingdom. The scarce records kept in the Archivo Histórico Nacional, section Órdenes Militares, referring to slaves, help to understand the development of traffic, work and manumission of these people.

Las órdenes militares dispusieron desde su fundación de mano de obra esclava en sus tierras, pero la institución que mejor sirve para estudiar la esclavitud en los siglos XII y XIII en los reinos de León y Castilla son los hospitales para la redención de cautivos de la Orden de Santiago. Estas instituciones disponían de espacio para alojar a los cautivos mientras se negociaban rescates con los poderes islámicos, y atendían a la redistribución de aquellos musulmanes que, por no haber sido redimidos, pasaban a ser esclavos de la propia orden o a ser vendidos en los mercados de los reinos cristianos. Los escasos documentos de la sección de Órdenes Militares del Archivo Histórico Nacional dedicados a esclavos ayudan a comprender el funcionamiento del tráfico, trabajo y liberación de este colectivo.

Some high-current ion sources for materials modification

International Nuclear Information System (INIS)

Taylor, T.

1989-01-01

Ion sources for materials modification have evolved through three distinct generations. The first generation was adopted from research accelerators. These cold-cathode plasma-discharge devices generate beam currents of less than 100 μA. The hot-cathode plasma-discharge ion sources, originally developed for isotope separation, comprise the second generation. They produce between 100 μA and 10 mA of beam current. The third generation ion sources give beam currents in excess of 10 mA. This technology, transferred from industrial accelerators, has already made SIMOX (Separation by IMplanted OXygen) into a commercially viable semiconductor process and promises to do the same for ion implantation of metals and insulators. The author focuses on the third generation technology that will play a key role in the future of ion implantation. 10 refs.; 5 figs.; 2 tabs

Genetic modification and genetic determinism

Science.gov (United States)

Resnik, David B; Vorhaus, Daniel B

2006-01-01

In this article we examine four objections to the genetic modification of human beings: the freedom argument, the giftedness argument, the authenticity argument, and the uniqueness argument. We then demonstrate that each of these arguments against genetic modification assumes a strong version of genetic determinism. Since these strong deterministic assumptions are false, the arguments against genetic modification, which assume and depend upon these assumptions, are therefore unsound. Serious discussion of the morality of genetic modification, and the development of sound science policy, should be driven by arguments that address the actual consequences of genetic modification for individuals and society, not by ones propped up by false or misleading biological assumptions. PMID:16800884

Genetic modification and genetic determinism

Directory of Open Access Journals (Sweden)

Vorhaus Daniel B

2006-06-01

Full Text Available Abstract In this article we examine four objections to the genetic modification of human beings: the freedom argument, the giftedness argument, the authenticity argument, and the uniqueness argument. We then demonstrate that each of these arguments against genetic modification assumes a strong version of genetic determinism. Since these strong deterministic assumptions are false, the arguments against genetic modification, which assume and depend upon these assumptions, are therefore unsound. Serious discussion of the morality of genetic modification, and the development of sound science policy, should be driven by arguments that address the actual consequences of genetic modification for individuals and society, not by ones propped up by false or misleading biological assumptions.

Safety of modifications at nuclear power plants - the role of minor modifications and human and organisational factors

International Nuclear Information System (INIS)

2005-01-01

Operating experience repeatedly shows that changes and modifications at nuclear power plants (NPPs) may lead to safety significant events. At the same time, modifications are necessary to ensure a safe and economic functioning of the NPPs. To ensure safety in all plant configurations it is important that modification processes are given proper attention both by the utilities and the regulators. The operability, maintainability and testability of every modification should be thoroughly assessed from different points of view to ensure that no safety problems are introduced. The OECD/NEA Committee on Safety of Nuclear Installations (CSNI) has recently addressed the issue of modifications by organising a 'Workshop on Modifications at Nuclear Power Plants Operating Experience, Safety Significance and Role of Human Factors'. This workshop was undertaken as a joint effort of the Working Group on Operating Experience (WGOE) and the Special Experts Group on Human and Organisational Factors (SEGHOF), and it was held at the OECD Headquarters in Paris on October 6 to 8, 2003. The initiative to organise the workshop was taken by the WGOE and the SEGHOF based on findings from events and incidents due to modifications at nuclear power plants in the world and weaknesses experienced in modification processes. During the workshop, the WGOE focused on the theme of 'Minor Modifications and their Safety Significance', while the SEGHOF focused on the topic 'Human and Organisational Factors in NPP Modifications'. This report is based on material collected before the workshop, the workshop proceedings, discussions of the group of experts responsible for the arrangement of the workshop, and additional material collected by a consultant. The workshop was preceded by extensive preparations, which included collection of national surveys in response to questionnaires on modifications at the NPPs. Not all of these surveys were available at the workshop, but their findings have now been included

Modification of JRR-2

International Nuclear Information System (INIS)

Miyasaka, Yasuhiko

1978-01-01

This report gives an outline of some of the main modifications carried out around the Reactor Core on the Research Reactor JRR-2, at the Tokai Research Establishment of JAERI. The JRR-2 was shut down in December 1973, to improve it in heavy water leakage from the metal packing between core tank and support ring, corrosion of the lower shielding plug, and fault in the control-rod mechanism. Main modifications were a standing seal weld at the support ring to stop heavy water leakage, replacement of the reactor top shield and improvement of the helium system. The control-rod assemblies and the refueling devices were replaced by the newly designed ones also. In addition to the modification plan, the irradiated air exhaust system was improved to reduce radioactive argon gas release through the stack. Works were completed successfully in September 1975. But a light water leakage occurred at the stand pipe below the light water tank on November 11, 1975, which was repaired in about 4 months. When considering the operation of above 5,000 hours after the modification, however, the quality of the modification work may be said to be quite satisfactory. The present report in which works to the completion are described may be valuable as a record of reactor modification which is a new experience at JAERI. (auth.)

A CRISPR New World: Attitudes in the Public toward Innovations in Human Genetic Modification.

Science.gov (United States)

Weisberg, Steven M; Badgio, Daniel; Chatterjee, Anjan

2017-01-01

The potential to genetically modify human germlines has reached a critical tipping point with recent applications of CRISPR-Cas9. Even as researchers, clinicians, and ethicists weigh the scientific and ethical repercussions of these advances, we know virtually nothing about public attitudes on the topic. Understanding such attitudes will be critical to determining the degree of broad support there might be for any public policy or regulation developed for genetic modification research. To fill this gap, we gave an online survey to a large (2,493 subjects) and diverse sample of Americans. Respondents supported genetic modification research, although demographic variables influenced these attitudes-conservatives, women, African-Americans, and older respondents, while supportive, were more cautious than liberals, men, other ethnicities, and younger respondents. Support was also was slightly muted when the risks (unanticipated mutations and possibility of eugenics) were made explicit. The information about genetic modification was also presented as contrasting vignettes, using one of five frames: genetic editing, engineering, hacking, modification, or surgery. Despite the fact that the media and academic use of frames describing the technology varies, these frames did not influence people's attitudes. These data contribute a current snapshot of public attitudes to inform policy with regard to human genetic modification.

A CRISPR New World: Attitudes in the Public toward Innovations in Human Genetic Modification

Directory of Open Access Journals (Sweden)

Steven M. Weisberg

2017-05-01

Full Text Available The potential to genetically modify human germlines has reached a critical tipping point with recent applications of CRISPR-Cas9. Even as researchers, clinicians, and ethicists weigh the scientific and ethical repercussions of these advances, we know virtually nothing about public attitudes on the topic. Understanding such attitudes will be critical to determining the degree of broad support there might be for any public policy or regulation developed for genetic modification research. To fill this gap, we gave an online survey to a large (2,493 subjects and diverse sample of Americans. Respondents supported genetic modification research, although demographic variables influenced these attitudes—conservatives, women, African-Americans, and older respondents, while supportive, were more cautious than liberals, men, other ethnicities, and younger respondents. Support was also was slightly muted when the risks (unanticipated mutations and possibility of eugenics were made explicit. The information about genetic modification was also presented as contrasting vignettes, using one of five frames: genetic editing, engineering, hacking, modification, or surgery. Despite the fact that the media and academic use of frames describing the technology varies, these frames did not influence people’s attitudes. These data contribute a current snapshot of public attitudes to inform policy with regard to human genetic modification.

Gas-discharge plasma processes for surface modification and conversion of chemical substances. Application for fuel cells

Energy Technology Data Exchange (ETDEWEB)

Schroeder, K.; Meyer, D.; Rohland, B.; Heintze, M.; Zahn, R.J.; Hannemann, M.; Meusinger, J.; Ohl, A. [Institute of Non-Thermal Plasma Physics, Greifswald (Germany)]|[Gesellschaft fuer Angewandte Technik mbH Greifswald (Germany)]|[GAPC, Adam Opel AG, IPC, Ruesselsheim (Germany)

2001-07-01

The potential of plasma processes towards hydrogen and fuel cell technology will be demonstrated by two examples with preliminary results: 1. plasma modification of polymer electrolyte membranes for direct methanol fuel cells, and 2. plasma supported steam reforming.

Permit application modifications

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-11-01

This document contains the Permit Application Modifications for the Y-12 Industrial Landfill V site on the Oak Ridge Reservation. These modifications include the assessment of stability of the proposed Landfill V under static and loading conditions. Analyses performed include the general slope stability, veneer stability of the bottom liner and cover system, and a liquefaction potential assessment of the foundation soils.

Permit application modifications

International Nuclear Information System (INIS)

1995-11-01

This document contains the Permit Application Modifications for the Y-12 Industrial Landfill V site on the Oak Ridge Reservation. These modifications include the assessment of stability of the proposed Landfill V under static and loading conditions. Analyses performed include the general slope stability, veneer stability of the bottom liner and cover system, and a liquefaction potential assessment of the foundation soils

Structural modification in the formation of starch - silver nanocomposites

Science.gov (United States)

Begum, S. N. Suraiya; Aswal, V. K.; Ramasamy, Radha Perumal

2016-05-01

Polymer based nanocomposites have gained wide applications in field of battery technology. Starch is a naturally occurring polysaccharide with sustainable properties such as biodegradable, non toxic, excellent film forming capacity and it also act as reducing agent for the metal nanoparticles. In our research various concentration of silver nitrate (AgNO3) was added to the starch solution and films were obtained using solution casting method. Surface electron microscope (SEM) of the films shows modifications depending upon the concentration of AgNO3. Small angle neutron scattering (SANS) analysis showed that addition of silver nitrate modifies the starch to disc like structures and with increasing the AgNO3 concentration leads to the formation of fractals. This research could benefit battery technology where solid polymer membranes using starch is used.

A Review of Ultrafiltration and Forward Osmosis:application and modification

Science.gov (United States)

Chao, Gong; Shuili, Yu; Yufei, Shangguan; Zhengyang, Gu; Wangzhen, Yang; Liumo, Ren

2018-03-01

As a new treatment, membrane filtration is playing a more prominent role in treating many kinds of wastewater. Among all the membrane technologies, ultrafiltration(UF) and forward osmosis(FO) technology has been widely utilized and developed in oil field and refinery produced water. However, the reports about the differences between the two kinds of membrane technology used in oily wastewater are not yet available. In this review, at first we introduce the advantages, shortcomings and applications of UF and FO membranes. Among these, we mainly illustrate the membrane fouling, which now is a big problem because it increases costs and decreases membrane life to limit the industrialization of the membrane, and the different modification methods of membranes are discussed to figure out how these ways can ease the membrane fouling. Next we make a comparison of the two membranes. Finally we illustrate the future research topics.

Rapid detection of genetic modification for GMO monitoring in agriculture

Directory of Open Access Journals (Sweden)

Petrović Sofija

2015-01-01

Full Text Available Transgenic technology has expanded the ways of new genetic variability creation. Genetically modified organisms (GMOs are organisms which total genome is altered in a way that could not happen in nature. GM crops recorded a steady increase in its share in agricultural production. However, for the most part, GMO in agriculture has been limited to two cultivars - soy and corn, and the two genetic modifications, the total herbicide resistance and pest of the Lepidoptera genus. In order to monitor cultivation and trade of GMOs, tests of different precision are used, qualitatively and/or quantitatively determining the presence of genetic modification. Tests for the rapid determination of the presence of GM are suitable, since they can be implemented quickly and accurately, in terms of declared sensitivity, outside or in the laboratory. The example of the use of rapid tests demonstrates their value in use for rapid and efficient monitoring.

Behavior Modification in Coaching.

Science.gov (United States)

Lynch, Annette Rutt; Stillman, Stephen M.

1979-01-01

An example of behavior modification used in athletic coaching is presented. The case study involves a member of a women's basketball team and details the use of behavior modification for both weight reduction and skill improvement. (JMF)

Quantitative proteomic characterization of redox-dependent post-translational modifications on protein cysteines

Energy Technology Data Exchange (ETDEWEB)

Duan, Jicheng; Gaffrey, Matthew J.; Qian, Wei-Jun

2017-01-01

Protein cysteine thiols play a crucial role in redox signaling, regulation of enzymatic activity and protein function, and maintaining redox homeostasis in living systems. The unique chemical reactivity of thiol groups makes cysteine susceptible to oxidative modifications by reactive oxygen and nitrogen species to form a broad array of reversible and irreversible protein post-translational modifications (PTMs). The reversible modifications in particular are one of the major components of redox signaling and are involved in regulation of various cellular processes under physiological and pathological conditions. The biological significance of these redox PTMs in health and diseases has been increasingly recognized. Herein, we review the recent advances of quantitative proteomic approaches for investigating redox PTMs in complex biological systems, including the general considerations of sample processing, various chemical or affinity enrichment strategies, and quantitative approaches. We also highlight a number of redox proteomic approaches that enable effective profiling of redox PTMs for addressing specific biological questions. Although some technological limitations remain, redox proteomics is paving the way towards a better understanding of redox signaling and regulation in human health and diseases.

Modification of a liquid hydrogen tank for integrated refrigeration and storage

Science.gov (United States)

Swanger, A. M.; Jumper, K. M.; Fesmire, J. E.; Notardonato, W. U.

2015-12-01

The modification and outfitting of a 125,000-liter liquid hydrogen tank was performed to provide integrated refrigeration and storage capability. These functions include zero boil-off, liquefaction, and densification and therefore require provisions for sub-atmospheric tank pressures within the vacuum-jacketed, multilayer insulated tank. The primary structural modification was to add stiffening rings inside the inner vessel. The internal stiffening rings were designed, built, and installed per the ASME Boiler and Pressure Vessel Code, Section VIII, to prevent collapse in the case of vacuum jacket failure in combination with sub-atmospheric pressure within the tank. For the integrated refrigeration loop, a modular, skeleton-type heat exchanger, with refrigerant temperature instrumentation, was constructed using the stiffening rings as supports. To support the system thermal performance testing, three custom temperature rakes were designed and installed along the 21-meter length of the tank, once again using rings as supports. The temperature rakes included a total of 20 silicon diode temperature sensors mounted both vertically and radially to map the bulk liquid temperature within the tank. The tank modifications were successful and the system is now operational for the research and development of integrated refrigeration technology.

Towards Enhanced Performance Thin-film Composite Membranes via Surface Plasma Modification

Science.gov (United States)

Reis, Rackel; Dumée, Ludovic F.; Tardy, Blaise L.; Dagastine, Raymond; Orbell, John D.; Schutz, Jürg A.; Duke, Mikel C.

2016-01-01

Advancing the design of thin-film composite membrane surfaces is one of the most promising pathways to deal with treating varying water qualities and increase their long-term stability and permeability. Although plasma technologies have been explored for surface modification of bulk micro and ultrafiltration membrane materials, the modification of thin film composite membranes is yet to be systematically investigated. Here, the performance of commercial thin-film composite desalination membranes has been significantly enhanced by rapid and facile, low pressure, argon plasma activation. Pressure driven water desalination tests showed that at low power density, flux was improved by 22% without compromising salt rejection. Various plasma durations and excitation powers have been systematically evaluated to assess the impact of plasma glow reactions on the physico-chemical properties of these materials associated with permeability. With increasing power density, plasma treatment enhanced the hydrophilicity of the surfaces, where water contact angles decreasing by 70% were strongly correlated with increased negative charge and smooth uniform surface morphology. These results highlight a versatile chemical modification technique for post-treatment of commercial membrane products that provides uniform morphology and chemically altered surface properties. PMID:27363670

Modification of the colony tower for the Rio Blanco detonation

International Nuclear Information System (INIS)

Blume, J.A.; Freeman, S.A.; Honda, K.K.; Lee, L.A.

1975-01-01

Supplemental structural bracing was designed and installed for the 180-ft-tall Colony Tower, an experimental oil shale processing retort structure, in anticipation of its lateral response to the Rio Blanco detonation. The tower is a steel structure with both horizontal and vertical diagonal bracing. Data obtained from the earlier Project Rulison detonation indicated that an evaluation study was necessary. Design criteria that would provide an adequate margin of safety were developed based on predicted Rio Blanco ground motion. The evaluation of the unmodified structure showed that several bracing members would be subjected to forces exceeding their yield strength, and some would reach a level at which failure could occur. Further analyses were made with assumed modified bracing members. A final scheme for modified vertical bracing was established and installed. After modification, the response of the tower during the Rio Blanco detonation was measured by instruments on the ground and at various locations on the tower, and no evidence of damage was discovered. The modification of the Colony Tower and the procedures used to determine these modifications show the usefulness of current ground motion and structural response prediction technology for forecasting dynamic behavior of important structures subjected to ground motion from underground nuclear explosions. (auth)

In vivo genome editing thrives with diversified CRISPR technologies

Directory of Open Access Journals (Sweden)

Xun Ma

2018-03-01

Full Text Available Prokaryotic type II adaptive immune systems have been developed into the versatile CRISPR technology, which has been widely applied in site-specific genome editing and has revolutionized biomedical research due to its superior efficiency and flexibility. Recent studies have greatly diversified CRISPR technologies by coupling it with various DNA repair mechanisms and targeting strategies. These new advances have significantly expanded the generation of genetically modified animal models, either by including species in which targeted genetic modification could not be achieved previously, or through introducing complex genetic modifications that take multiple steps and cost years to achieve using traditional methods. Herein, we review the recent developments and applications of CRISPR-based technology in generating various animal models, and discuss the everlasting impact of this new progress on biomedical research.

75 FR 26025 - Regulation of Fuels and Fuel Additives: Modifications to Renewable Fuel Standard Program

Science.gov (United States)

2010-05-10

... technologies, we have created new definitions for membrane separation and raw starch hydrolysis. We also... technical errors and areas within the final RFS2 regulations that could benefit from clarification or... benefit from clarification or modification. As a result, we are making the following amendments to the...

Decree number 5.885 dated of September 5, 2006

International Nuclear Information System (INIS)

2006-01-01

Promulgates the Regional Cooperation Agreement for the Promotion of Nuclear Science and Technology in Latin America and Caribbean - ARCAL, celebrated within the context of the International Atomic Energy Agency - IAEA, adopted in Vienna, on September 25, 1998 and signed by Brazil on August 4, 1999, with reservation to the Articles VI e XIII

Residential/commercial market for energy technologies

Energy Technology Data Exchange (ETDEWEB)

Glesk, M M

1979-08-01

The residential/commercial market sector, particularly as it relates to energy technologies, is described. Buildings account for about 25% of the total energy consumed in the US. Market response to energy technologies is influenced by several considerations. Some considerations discussed are: industry characteristics; market sectors; energy-consumption characeristics; industry forecasts; and market influences. Market acceptance may be slow or nonexistent, the technology may have little impact on energy consumption, and redesign or modification may be necessary to overcome belatedly perceived market barriers. 7 figures, 20 tables.

Industrial applications of low energy accelerator technologies

International Nuclear Information System (INIS)

Park, Jae Won; Kim, Hyung Jin; Kim, Jun Yeon; Lee, Jae Sang; Yeo, Sun Mog; Lee, Ji Ah

2008-05-01

Industrial application researches utilizing a beam extracting unit and an accelerator with an energy less than 3 MeV have been conducted. Although a number of industrial application areas exist, a few research items had been selected for this project, which include the gemstone coloration and the surface modifications of metals/polymers. In the case of gemstone coloration, the green/yellow colored diamond by a proton beam irradiation and blue color emitting sapphire utilizing Co ion implantation are being evaluated as the high potential for commercialization. And, the band gap structures as a result of impurities' doping was calculated with density functional theory (DFT) and it was found to be well consistent with experimental results. The surface modification of stainless juice extracting gears have been successful and patented, resulting in a technology transfer to the company. The reduction in the detachment of the metallic elements during juice extracting as a results of ion beam surface modification is expected to be broadly applicable to the other relevant industrial materials and parts. In the case of gemstone coloration, it is estimated to be one of the highest commercially valuable items because of its extremely low processing expense. The research results have been successful and is worth while transferring the technologies to the industrial sectors. During the second phase research, 6 SCI papers have been published and 9 patents have been submitted and 3 patents have been registered. 1 technology has been transferred to the company for industrialization and 1 technology is pending for a transference

Modifications of ORNL's computer programs MSF-21 and VTE-21 for the evaluation and rapid optimization of multistage flash and vertical tube evaporators

Energy Technology Data Exchange (ETDEWEB)

Glueckstern, P.; Wilson, J.V.; Reed, S.A.

1976-06-01

Design and cost modifications were made to ORNL's Computer Programs MSF-21 and VTE-21 originally developed for the rapid calculation and design optimization of multistage flash (MSF) and multieffect vertical tube evaporator (VTE) desalination plants. The modifications include additional design options to make possible the evaluation of desalting plants based on current technology (the original programs were based on conceptual designs applying advanced and not yet proven technological developments and design features) and new materials and equipment costs updated to mid-1975.

Mobile Phone Cognitive Bias Modification Research Platform for Substance Use Disorders: Protocol for a Feasibility Study.

Science.gov (United States)

Zhang, Melvyn; Ying, JiangBo; Song, Guo; Fung, Daniel Ss; Smith, Helen

2018-06-12

Cognitive biases refer to automatic attentional and interpretational tendencies, which could be retained by cognitive bias modification interventions. Cristea et al and Jones et al have published reviews (in 2016 and 2017 respectively) on the effectiveness of such interventions. The advancement of technologies such as electronic health (eHealth) and mobile health (mHealth) has led to them being harnessed for the delivery of cognitive bias modification. To date, at least eight studies have demonstrated the feasibility of mobile technologies for the delivery of cognitive bias modification. Most of the studies are limited to a description of the conventional cognitive bias modification methodology that has been adopted. None of the studies shared the developmental process for the methodology involved, such that future studies could adopt it in the cost-effective replication of such interventions. It is important to have a common platform that could facilitate the design and customization of cognitive bias modification interventions for a variety of psychiatric and addictive disorders. It is the aim of the current research protocol to describe the design of a research platform that allows for customization of cognitive bias modification interventions for addictive disorders. A multidisciplinary team of 2 addiction psychiatrists, a psychologist with expertise in cognitive bias modification, and a computer engineer, were involved in the development of the intervention. The proposed platform would comprise of a mobile phone version of the cognitive bias task which is controlled by a server that could customize the algorithm for the tasks and collate the reaction-time data in realtime. The server would also allow the researcher to program the specific set of images that will be present in the task. The mobile phone app would synchronize with the backend server in real-time. An open-sourced cross-platform gaming software from React Native was used in the current development

The management of modifications

International Nuclear Information System (INIS)

Bernard, C.

1992-01-01

Description of the management methods of modifications at EDF. To maintain safety standards of the nuclear power station the 'Direction de l'Equipment' and the 'Direction du Parc en Exploitation' have jointly fixed the modalities of management for all modifications and recorded them in a 'Practical Guide'

Technical support for the Ohio Clean Coal Technology Program. Volume 2, Baseline of knowledge concerning process modification opportunities, research needs, by-product market potential, and regulatory requirements: Final report

Energy Technology Data Exchange (ETDEWEB)

Olfenbuttel, R.; Clark, S.; Helper, E.; Hinchee, R.; Kuntz, C.; Means, J.; Oxley, J.; Paisley, M.; Rogers, C.; Sheppard, W.; Smolak, L. [Battelle, Columbus, OH (United States)

1989-08-28

This report was prepared for the Ohio Coal Development Office (OCDO) under Grant Agreement No. CDO/R-88-LR1 and comprises two volumes. Volume 1 presents data on the chemical, physical, and leaching characteristics of by-products from a wide variety of clean coal combustion processes. Volume 2 consists of a discussion of (a) process modification waste minimization opportunities and stabilization considerations; (b) research and development needs and issues relating to clean coal combustion technologies and by-products; (c) the market potential for reusing or recycling by-product materials; and (d) regulatory considerations relating to by-product disposal or reuse.

A simple ion implanter for material modifications in agriculture and gemmology

Science.gov (United States)

Singkarat, S.; Wijaikhum, A.; Suwannakachorn, D.; Tippawan, U.; Intarasiri, S.; Bootkul, D.; Phanchaisri, B.; Techarung, J.; Rhodes, M. W.; Suwankosum, R.; Rattanarin, S.; Yu, L. D.

2015-12-01

In our efforts in developing ion beam technology for novel applications in biology and gemmology, an economic simple compact ion implanter especially for the purpose was constructed. The designing of the machine was aimed at providing our users with a simple, economic, user friendly, convenient and easily operateable ion implanter for ion implantation of biological living materials and gemstones for biotechnological applications and modification of gemstones, which would eventually contribute to the national agriculture, biomedicine and gem-industry developments. The machine was in a vertical setup so that the samples could be placed horizontally and even without fixing; in a non-mass-analyzing ion implanter style using mixed molecular and atomic nitrogen (N) ions so that material modifications could be more effective; equipped with a focusing/defocusing lens and an X-Y beam scanner so that a broad beam could be possible; and also equipped with a relatively small target chamber so that living biological samples could survive from the vacuum period during ion implantation. To save equipment materials and costs, most of the components of the machine were taken from decommissioned ion beam facilities. The maximum accelerating voltage of the accelerator was 100 kV, ideally necessary for crop mutation induction and gem modification by ion beams from our experience. N-ion implantation of local rice seeds and cut gemstones was carried out. Various phenotype changes of grown rice from the ion-implanted seeds and improvements in gemmological quality of the ion-bombarded gemstones were observed. The success in development of such a low-cost and simple-structured ion implanter provides developing countries with a model of utilizing our limited resources to develop novel accelerator-based technologies and applications.

A simple ion implanter for material modifications in agriculture and gemmology

International Nuclear Information System (INIS)

Singkarat, S.; Wijaikhum, A.; Suwannakachorn, D.; Tippawan, U.; Intarasiri, S.; Bootkul, D.; Phanchaisri, B.; Techarung, J.; Rhodes, M.W.; Suwankosum, R.; Rattanarin, S.; Yu, L.D.

2015-01-01

In our efforts in developing ion beam technology for novel applications in biology and gemmology, an economic simple compact ion implanter especially for the purpose was constructed. The designing of the machine was aimed at providing our users with a simple, economic, user friendly, convenient and easily operateable ion implanter for ion implantation of biological living materials and gemstones for biotechnological applications and modification of gemstones, which would eventually contribute to the national agriculture, biomedicine and gem-industry developments. The machine was in a vertical setup so that the samples could be placed horizontally and even without fixing; in a non-mass-analyzing ion implanter style using mixed molecular and atomic nitrogen (N) ions so that material modifications could be more effective; equipped with a focusing/defocusing lens and an X–Y beam scanner so that a broad beam could be possible; and also equipped with a relatively small target chamber so that living biological samples could survive from the vacuum period during ion implantation. To save equipment materials and costs, most of the components of the machine were taken from decommissioned ion beam facilities. The maximum accelerating voltage of the accelerator was 100 kV, ideally necessary for crop mutation induction and gem modification by ion beams from our experience. N-ion implantation of local rice seeds and cut gemstones was carried out. Various phenotype changes of grown rice from the ion-implanted seeds and improvements in gemmological quality of the ion-bombarded gemstones were observed. The success in development of such a low-cost and simple-structured ion implanter provides developing countries with a model of utilizing our limited resources to develop novel accelerator-based technologies and applications.

A simple ion implanter for material modifications in agriculture and gemmology

Energy Technology Data Exchange (ETDEWEB)

Singkarat, S. [Plasma and Beam Physics Research Facility, Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200 (Thailand); Thailand Center of Excellence in Physics, Commission on Higher Education, 328 Si Ayutthaya Road, Bangkok 10400 (Thailand); Wijaikhum, A. [Plasma and Beam Physics Research Facility, Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200 (Thailand); Department of Physics, University of York, Heslington, York YO10 5DD (United Kingdom); Suwannakachorn, D.; Tippawan, U. [Plasma and Beam Physics Research Facility, Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200 (Thailand); Intarasiri, S. [Science and Technology Research Institute, Chiang Mai University, Chiang Mai 50200 (Thailand); Bootkul, D. [Department of General Science, Faculty of Science, Srinakharinwirot University, Bangkok 10110 (Thailand); Phanchaisri, B.; Techarung, J. [Science and Technology Research Institute, Chiang Mai University, Chiang Mai 50200 (Thailand); Rhodes, M.W.; Suwankosum, R.; Rattanarin, S. [Plasma and Beam Physics Research Facility, Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200 (Thailand); Yu, L.D., E-mail: yuld@thep-center.org [Plasma and Beam Physics Research Facility, Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200 (Thailand); Thailand Center of Excellence in Physics, Commission on Higher Education, 328 Si Ayutthaya Road, Bangkok 10400 (Thailand)

2015-12-15

In our efforts in developing ion beam technology for novel applications in biology and gemmology, an economic simple compact ion implanter especially for the purpose was constructed. The designing of the machine was aimed at providing our users with a simple, economic, user friendly, convenient and easily operateable ion implanter for ion implantation of biological living materials and gemstones for biotechnological applications and modification of gemstones, which would eventually contribute to the national agriculture, biomedicine and gem-industry developments. The machine was in a vertical setup so that the samples could be placed horizontally and even without fixing; in a non-mass-analyzing ion implanter style using mixed molecular and atomic nitrogen (N) ions so that material modifications could be more effective; equipped with a focusing/defocusing lens and an X–Y beam scanner so that a broad beam could be possible; and also equipped with a relatively small target chamber so that living biological samples could survive from the vacuum period during ion implantation. To save equipment materials and costs, most of the components of the machine were taken from decommissioned ion beam facilities. The maximum accelerating voltage of the accelerator was 100 kV, ideally necessary for crop mutation induction and gem modification by ion beams from our experience. N-ion implantation of local rice seeds and cut gemstones was carried out. Various phenotype changes of grown rice from the ion-implanted seeds and improvements in gemmological quality of the ion-bombarded gemstones were observed. The success in development of such a low-cost and simple-structured ion implanter provides developing countries with a model of utilizing our limited resources to develop novel accelerator-based technologies and applications.

Human Rights and Behavior Modification

Science.gov (United States)

Roos, Philip

1974-01-01

Criticisms of behavior modification, which charge that it violates ethical and legal principles, are discussed and reasons are presented to explain behavior modification's susceptibility to attack. (GW)

Modifications of allergenicity linked to food technologies.

Science.gov (United States)

Moneret-Vautrin, D A

1998-01-01

The prevalence of food allergies (FA) has increased over the past fifteen years. The reasons suggested are changes in dietary behaviour and the evolution of food technologies. New cases of FA have been described with chayote, rambutan, arguta, pumpkin seeds, custard apple, and with mycoproteins from Fusarium.... Additives using food proteins are at high risk: caseinates, lysozyme, cochineal red, papaïn, alpha-amylase, lactase etc. Heating can reduce allergenicity or create neo-allergens, as well as storage, inducing the synthesis of allergenic stress or PR proteins. Aeroallergens (miles, moulds) contaminate foods and can induce allergic reactions. Involuntary contamination by peanut proteins on production lines is a problem which is not yet solved. Genetically modified plants are at risk of allergenicity, requiring methodological steps of investigations: the comparison of the amino-acid sequence of the transferred protein with the sequence of known allergens, the evaluation of thermo degradability and of the denaturation by pepsin and trypsin are required, as well as the study with sera from patients allergic to the plant producing the gene. The combination of enzymatic hydrolysis, heating, or the development of genetically modified plants may offer new alternatives towards hypoallergenic foods (57 references).

Novel approaches in food-processing technology: new technologies for preserving foods and modifying function.

Science.gov (United States)

Knorr, D

1999-10-01

Recent advances in emerging food-processing technologies, such as high hydrostatic pressure or high-intensity electric field pulses, allow targeted and sophisticated modification and preservation of foods. We are beginning to understand the mechanisms involved in pressure inactivation of bacterial spores and have been collecting considerable amounts of kinetic data regarding inactivation mechanisms of enzymes and vegetative microorganisms. We are also gaining more insight into the permeabilization of plant membranes and related biosynthetic responses, making progress in food structure engineering and food modification for function, and have been initiating process developments for gentle processing of delicate biomaterials based on pressure-assisted phase transitions of water.

Structural modification in the formation of starch – silver nanocomposites

Energy Technology Data Exchange (ETDEWEB)

Begum, S. N. Suraiya; Ramasamy, Radha Perumal, E-mail: perumal.ramasamy@gmail.com [Department of Applied Science and Technology, A.C.Tech. Campus, Anna University, Chennai – 600 025 (India); Aswal, V. K. [Solid State Physics Division, Bhabha Atomic Research Center, Trombay, Mumbai (India)

2016-05-23

Polymer based nanocomposites have gained wide applications in field of battery technology. Starch is a naturally occurring polysaccharide with sustainable properties such as biodegradable, non toxic, excellent film forming capacity and it also act as reducing agent for the metal nanoparticles. In our research various concentration of silver nitrate (AgNO{sub 3}) was added to the starch solution and films were obtained using solution casting method. Surface electron microscope (SEM) of the films shows modifications depending upon the concentration of AgNO{sub 3}. Small angle neutron scattering (SANS) analysis showed that addition of silver nitrate modifies the starch to disc like structures and with increasing the AgNO{sub 3} concentration leads to the formation of fractals. This research could benefit battery technology where solid polymer membranes using starch is used.

Structural modification in the formation of starch – silver nanocomposites

International Nuclear Information System (INIS)

Begum, S. N. Suraiya; Ramasamy, Radha Perumal; Aswal, V. K.

2016-01-01

Polymer based nanocomposites have gained wide applications in field of battery technology. Starch is a naturally occurring polysaccharide with sustainable properties such as biodegradable, non toxic, excellent film forming capacity and it also act as reducing agent for the metal nanoparticles. In our research various concentration of silver nitrate (AgNO_3) was added to the starch solution and films were obtained using solution casting method. Surface electron microscope (SEM) of the films shows modifications depending upon the concentration of AgNO_3. Small angle neutron scattering (SANS) analysis showed that addition of silver nitrate modifies the starch to disc like structures and with increasing the AgNO_3 concentration leads to the formation of fractals. This research could benefit battery technology where solid polymer membranes using starch is used.

A hurricane modification process, applying a new technology tested for warm cloud seeding to produce artificial rains

Science.gov (United States)

Imai, T.; Martin, I.; Iha, K.

A Hurricane Modification Process with application of a new clean technology attested for seeding warm clouds with collector pure water droplets of controlled size to produce artificial rains in warm clouds is proposed to modify the hurricanes in order to avoid their formation or to modify the trajectory or to weaken hurricanes in action The Process is based on the time-dependent effects of cloud droplets microphysical processes for the formation and growth of the natural water droplets inside the clouds releasing large volumes of Aeolian energy to form the strong rotative upside air movements A new Paradigm proposed explain the strong and rotative winds created with the water droplets formation and grow process releasing the rotative Aeolian Energy in Tornados and Hurricanes This theory receive the Gold Medal Award of the Water Science in the 7th International Water Symposium 2005 in France Artificial seeding in the Process studies condensing a specified percentage of the water vapor to liquid water droplets where we observe the release of larges intensity of the Aeolian energy creates the hurricanes producing appreciable perturbations With they rotating strong wind created by the water droplets releasing Aeolian energy The Amplitudes of these winds are comparable to natural disasters Once this natural thermal process is completely understood artificial process to modify the hurricanes become scientifically possible to avoid them to happen or to deviate their trajectory or to weaken the already formed hurricanes In this work

Behavior Modification in the Classroom

Science.gov (United States)

Whitman, Mryon; Whitman, Joan

1971-01-01

This article presents the theoretical rationale for behavior modification, principally through its comparison with traditional psychotherapies, and suggests some behavior modification techniques for the classroom management of maladaptive behavior. (Author)

The interplay of post-translational modification and gene therapy

Directory of Open Access Journals (Sweden)

Osamor VC

2016-02-01

Full Text Available Victor Chukwudi Osamor,1–3 Shalom N Chinedu,3,4 Dominic E Azuh,3,5 Emeka Joshua Iweala,3,4 Olubanke Olujoke Ogunlana3,4 1Covenant University Bioinformatics Research (CUBRe Unit, Department of Computer and Information Sciences, College of Science and Technology (CST, Covenant University, Ota, Ogun State, Nigeria; 2Institute of Informatics (Computational biology and Bioinformatics, Faculty of Mathematics, Informatics and Mechanics, University of Warsaw (Uniwersytet Warszawski, Warszawa, Poland; 3Covenant University Public Health and Well-being Research Group (CUPHWERG, Covenant University, 4Biochemistry and Molecular Biology Unit, Department of Biological Sciences, College of Science and Technology, Covenant University, Canaan Land, 5Department of Economics and Development Studies, Covenant University, Ota, Ogun State, Nigeria Abstract: Several proteins interact either to activate or repress the expression of other genes during transcription. Based on the impact of these activities, the proteins can be classified into readers, modifier writers, and modifier erasers depending on whether histone marks are read, added, or removed, respectively, from a specific amino acid. Transcription is controlled by dynamic epigenetic marks with serious health implications in certain complex diseases, whose understanding may be useful in gene therapy. This work highlights traditional and current advances in post-translational modifications with relevance to gene therapy delivery. We report that enhanced understanding of epigenetic machinery provides clues to functional implication of certain genes/gene products and may facilitate transition toward revision of our clinical treatment procedure with effective fortification of gene therapy delivery. Keywords: post-translational modification, gene therapy, epigenetics, histone, methylation

La visita del papa Benet XIII a València de 1414-1415: una aproximació a la seua memòria en la tradició historiogràfica valenciana

Directory of Open Access Journals (Sweden)

Blai Josep Server Server

2017-06-01

Full Text Available L’article analitza els testimonis de la visita de Benet XIII, Pero Martínez de Luna, a la ciutat de València entre desembre de 1414 i juliol de 1415 conservats en la tradició historiogràfica valenciana. En concret, s’hi examinen les obres valencianes de caràcter memorialístic (cròniques i dietaris, principalment que, des del segle XV i fins a l’actualitat, han parat atenció a l’esdeveniment, per concloure que la memòria del mateix es conservà sobretot en els cercles del poder eclesiàstic –particularment entorn de la Seu– i municipal de la ciutat. Més enllà d’aquests àmbits, la visita papal fou progressivament oblidada, a pesar de l’impacte notable que degué tindre sobre aquells que la visqueren directament o en tingueren notícia indirectament a l’inici del segle XV.

3. International Symposium 'Vacuum Technology and Equipment'. ISVTE-3

International Nuclear Information System (INIS)

Kogan, V.S.; Shulaev, V.M.

1999-01-01

The reports of the 3th International Symposium 'Vacuum Technology and Equipment', which was held in Kharkov at 22-24 September 1999 are presented. In this issue such subject are published: equipment and technology for thin and coating preparation. Studies of their surface layer and material modification by corpuscular effect and light

Antroponimia femminile nella Scozia del XIII secolo: la testimonianza del Ragman Roll (1296 Feminine anthroponyms in 13th-century Scotland: the Ragman Roll (1296

Directory of Open Access Journals (Sweden)

Valeria Di Clemente

2012-10-01

Full Text Available La serie di documenti nota come Ragman Roll raccoglie i giuramenti di fedeltà e l’omaggio feudale resi da aristocratici, ecclesiastici, proprietari terrieri e borghesi di Scozia a Edoardo I Plantageneto dopo la campagna di occupazione inglese della primavera-estate 1296. In questa veste, essa riporta nomi e cognomi di circa 1800 persone, rappresentando una fonte preziosa per lo studio dell’antroponimia in uso in Scozia nella seconda metà del XIII secolo. Il presente saggio esamina gli antroponimi femminili nelle forme ricorrenti nel documento, ricostruendone la vicenda storico-etimologica e culturale.

The documents known as Ragman Roll collect the fealty oaths sworn and the homages rendered by Scottish nobility, clergy, landowners and burgesses to Edward I Plantagenet after the English invasion of Scotland in the spring and summer of 1296. These documents record personal names and surnames of ca. 1800 people, being a precious source for the study of Scottish anthroponymy in the second half of the 13^th century. This paper focuses on the feminine anthroponyms occurring in the Ragman Roll, on their form and on their historical-etymological and cultural background.

Modifications to Replacement Costs System

International Nuclear Information System (INIS)

Godec, M.

1989-01-01

The purpose of this memorandum is to document the improvements and modifications made to the Replacement Costs of Crude Oil (REPCO) Supply Analysis System. While some of this work was performed under our previous support contract to DOE/ASFE, we are presenting all modifications and improvements are presented here for completeness. The memo primarily documents revisions made to the Lower-48 Onshore Model. Revisions and modifications made to other components and models in the REPCO system which are documented elsewhere are only highlighted in this memo. Generally, the modifications made to the Lower-48 Onshore Model reflect changes that have occurred in domestic drilling, oil field costs, and reserves since 1982, the date of the most recent available data used for the original Replacement Costs report, published in 1985

Value-impact assessment of safety-related modifications

International Nuclear Information System (INIS)

Knowles, W.M.C.; Dinnie, K.S.; Gordon, C.W.

1992-01-01

Like other nuclear utilities, Ontario Hydro, as part of its risk management activities, continually assesses the safety of its nuclear operations. In addition, new regulatory requirements are being applied to the older nuclear power plants. Both of these result in proposed plant modifications designed to reduce the risk to the public. However, modifications to an operating plant can have serious economic effects, and the resources, both financial and personnel, required for the implementation of these modifications are limited. Thus, all potential benefits and effects of a proposed modification must be thoroughly investigated to judge whether the modification is beneficial. Ontario Hydro has begun to use comprehensive value-impact assessments, utilizing plant-specific probabilistic risk assessments (PRAs), as tools to provide an informed basis for judgments on the benefit of safety-related modifications. The results from value-impact assessments can also be used to prioritize the implementation of these modifications

Balancing the unknown: Consumer judgment of unfamiliar technologies

DEFF Research Database (Denmark)

Hagemann, Kit; Scholderer, Joachim

The aim of the present paper is to explain how consumers form attitudes towards upstream food technologies in the absence of direct experience or in-depth information about the technology and the products resulting from its application. Using Structural Equation Modelling (SEM) we compared three...... food technologies against genetically modification (GM) and found that previously held attitude toward GM influenced attitude toward all three food technologies. The findings suggest that consumers form a set of heuristics that consist of general socio-political attitudes and these heuristics are used...

Technology Acceptance Model: A Survey of Literature

Directory of Open Access Journals (Sweden)

Priyanka Surendran

2013-07-01

Full Text Available The technology acceptance model has been a theory that is most widely used to explain an individual’s acceptance of an information system. This study has reviewed numerous literatures available in this area. The different studies in this area were evaluated to understand the modifications that were done on this model. The paper then tries to provide an insight on future trends in the technology acceptance model.

Antibiotic Modification of Native Grafts: Improving upon nature's scaffolds

Science.gov (United States)

Ketonis, Constantinos

The use of allograft bone in orthopaedics, spine surgery and dentistry is invaluable for helping restore bone defects and promote osteointegration. However, one, and perhaps the most important, problem associated with the use of allograft is infection. It is a devastating complication for patients and physicians alike, and necessitates repeated surgeries, extended treatment and often times results in increased morbidity and poor outcomes. Previous attempts to incorporate antibiotics into allograft by soaking the graft in antibiotic solution have enjoyed limited success in providing adequate protection against bacterial colonization. To overcome problems associated with controlled release systems, I have described a novel chemical modification that allows for the attachment of vancomycin, or other antibiotics, to free amines of allograft bone thus rendering the graft bactericidal over a long time period. This modification, as evaluated by immunohistochemistry, allowed for the uniform and stable attachment of antibiotics to allograft without adversely affecting its potential for incorporation with bone. Modified allograft, placed in the presence of S. aureus, did not allow colonization by bacteria as evaluated by fluorescent imaging, scanning microscopy, and direct bacterial counts. More importantly, inhibition of bacterial colonization resulted in prevention of biofilm formation. Furthermore, I show that the spectrum of activity of the parent antibiotic was maintained, as the construct was not active against E. coli challenges. Comparison of this technology with simple antibiotic incorporation demonstrated that the covalently-coupled antibiotic did not elute from the bone, but rather remained attached and active on the surface for times out to one year, times that are far longer than currently can be achieved with the elution technologies. Despite its potent activity against bacteria, modified bone remained biocompatible allowing attachment of osteoblastic

Modification of Sr on 4004 Aluminum Alloy

Science.gov (United States)

Guo, Erjun; Cao, Guojian; Feng, Yicheng; Wang, Liping; Wang, Guojun; Lv, Xinyu

2013-05-01

As a brazing foil, 4004 Al alloy has good welding performance. However, the high Si content decreases the plasticity of the alloy. To improve the plasticity of 4004 Al alloy and subsequently improve the productivity of 4004 Al foil or 434 composite foil, 4004 Al alloy was modified by Al-10%Sr master alloy. Modification effects of an additional amount of Sr, modification temperature, and holding time on 4004 aluminum alloy were studied by orthogonal design. The results showed that the greatest impact parameter of 4004 aluminum alloy modification was the additional amount of Sr, followed by holding time and modification temperature. The optimum modification parameters obtained by orthogonal design were as follows: Sr addition of 0.04%, holding time of 60 min, and modification temperature of 760°C. The effect of Sr addition on modification was analyzed in detail based on orthogonal results. With increasing of Sr addition, elongation of 4004 alloy increased at first, and decreased after reaching the maximum value.

Chemical Modifications of Starch: Microwave Effect

Directory of Open Access Journals (Sweden)

Kamila Lewicka

2015-01-01

Full Text Available This paper presents basic methods of starch chemical modification, the effect of microwave radiation on the modification process, and the physicochemical properties of starch. It has been shown that the modifications contribute to improvement of the material performance and likewise to significant improvement of its mechanical properties. As a result, more and more extensive use of starch is possible in various industries. In addition, methods of oxidized starch and starch esters preparation are discussed. Properties of microwave radiation and its impact on starch (with particular regard to modifications described in literature are characterized.

Modification Semantics in Now-Relative Databases

DEFF Research Database (Denmark)

Torp, Kristian; Jensen, Christian Søndergaard; Snodgrass, R. T.

2004-01-01

Most real-world databases record time-varying information. In such databases, the notion of ??the current time,?? or NOW, occurs naturally and prominently. For example, when capturing the past states of a relation using begin and end time columns, tuples that are part of the current state have some...... past time as their begin time and NOW as their end time. While the semantics of such variable databases has been described in detail and is well understood, the modification of variable databases remains unexplored. This paper defines the semantics of modifications involving the variable NOW. More...... specifically,  the problems with modifications in the presence of NOW are explored, illustrating that the main problems are with modifications of tuples that reach into the future. The paper defines the semantics of modifications?including insertions, deletions, and updates?of databases without NOW, with NOW...

Contribution to the study of plasmatic fibrinogen and serum albumin: effects of irradiation; Contribution a l'etude du fibrinogene et de la serum-albumine plasmatiques - effets de l'irradiation

Energy Technology Data Exchange (ETDEWEB)

Suscillon, M [Commissariat a l' Energie Atomique, Centre d' Etudes Nucleaires de Grenoble, 38 (France)

1967-07-01

The author studies the modifications of properties and structure of serum albumin and fibrinogen solution when subjected to radiation of low energy (X rays). On the other hand, two original techniques are exposed: 1. Amperometric determination of fibrin stabilizing factor or factor XIII of hemostasis. 2. Spectrophotometric study of fibrin formation kinetics. Then showing off and quantitative determination of platelets fibrinogen is exposed. (author) [French] L'auteur etudie les modifications des proprietes et de la structure des molecules de serum-albumine et de fibrinogene en solution soumise a un flux de RX de basse energie. D'autre part deux techniques originales sont exposees : 1. Dosage amperometrique du facteur stabilisant de la fibrine. 2. Etude spectrophotometrique de la cinetique de la fibro-formation. Enfin une mise en evidence et un dosage du fibrinogene plaquettaire sont presentes. (auteur)

Contribution to the study of plasmatic fibrinogen and serum albumin: effects of irradiation; Contribution a l'etude du fibrinogene et de la serum-albumine plasmatiques - effets de l'irradiation

Energy Technology Data Exchange (ETDEWEB)

Suscillon, M. [Commissariat a l' Energie Atomique, Centre d' Etudes Nucleaires de Grenoble, 38 (France)

1967-07-01

The author studies the modifications of properties and structure of serum albumin and fibrinogen solution when subjected to radiation of low energy (X rays). On the other hand, two original techniques are exposed: 1. Amperometric determination of fibrin stabilizing factor or factor XIII of hemostasis. 2. Spectrophotometric study of fibrin formation kinetics. Then showing off and quantitative determination of platelets fibrinogen is exposed. (author) [French] L'auteur etudie les modifications des proprietes et de la structure des molecules de serum-albumine et de fibrinogene en solution soumise a un flux de RX de basse energie. D'autre part deux techniques originales sont exposees : 1. Dosage amperometrique du facteur stabilisant de la fibrine. 2. Etude spectrophotometrique de la cinetique de la fibro-formation. Enfin une mise en evidence et un dosage du fibrinogene plaquettaire sont presentes. (auteur)

Surface Modifications in Adhesion and Wetting

Science.gov (United States)

Longley, Jonathan

Advances in surface modification are changing the world. Changing surface properties of bulk materials with nanometer scale coatings enables inventions ranging from the familiar non-stick frying pan to advanced composite aircraft. Nanometer or monolayer coatings used to modify a surface affect the macro-scale properties of a system; for example, composite adhesive joints between the fuselage and internal frame of Boeing's 787 Dreamliner play a vital role in the structural stability of the aircraft. This dissertation focuses on a collection of surface modification techniques that are used in the areas of adhesion and wetting. Adhesive joints are rapidly replacing the familiar bolt and rivet assemblies used by the aerospace and automotive industries. This transition is fueled by the incorporation of composite materials into aircraft and high performance road vehicles. Adhesive joints have several advantages over the traditional rivet, including, significant weight reduction and efficient stress transfer between bonded materials. As fuel costs continue to rise, the weight reduction is accelerating this transition. Traditional surface pretreatments designed to improve the adhesion of polymeric materials to metallic surfaces are extremely toxic. Replacement adhesive technologies must be compatible with the environment without sacrificing adhesive performance. Silane-coupling agents have emerged as ideal surface modifications for improving composite joint strength. As these coatings are generally applied as very thin layers (coatings using the buckling instability formed between two materials of a large elastic mismatch. The elastic modulus is found to effectively predict the joint strength of an epoxy/aluminum joint that has been reinforced with silane coupling agents. This buckling technique is extended to investigate the effects of chemical composition on the elastic modulus. Finally, the effect of macro-scale roughness on silane-reinforced joints is investigated

Wettability Modification of Nanomaterials by Low-Energy Electron Flux

Directory of Open Access Journals (Sweden)

Torchinsky I

2009-01-01

Full Text Available Abstract Controllable modification of surface free energy and related properties (wettability, hygroscopicity, agglomeration, etc. of powders allows both understanding of fine physical mechanism acting on nanoparticle surfaces and improvement of their key characteristics in a number of nanotechnology applications. In this work, we report on the method we developed for electron-induced surface energy and modification of basic, related properties of powders of quite different physical origins such as diamond and ZnO. The applied technique has afforded gradual tuning of the surface free energy, resulting in a wide range of wettability modulation. In ZnO nanomaterial, the wettability has been strongly modified, while for the diamond particles identical electron treatment leads to a weak variation of the same property. Detailed investigation into electron-modified wettability properties has been performed by the use of capillary rise method using a few probing liquids. Basic thermodynamic approaches have been applied to calculations of components of solid–liquid interaction energy. We show that defect-free, low-energy electron treatment technique strongly varies elementary interface interactions and may be used for the development of new technology in the field of nanomaterials.

Experimental Study on Modification of Concrete with Asphalt Admixture

Science.gov (United States)

Bołtryk, Michał; Małaszkiewicz, Dorota; Pawluczuk, Edyta

2017-10-01

Durability of engineering structures made of cement concrete with high compressive strength is a very vital issue, especially when they are exposed to different aggressive environments and dynamic loads. Concrete resistance to weathering actions and chemical attack can be improved by combined chemical and mechanical modification of concrete microstructure. Asphalt admixture in the form of asphalt paste (AP) was used for chemical modification of cement composite microstructure. Concrete structure was formed using special technology of compaction. A stand for vibro-vibropressing with regulated vibrator force and pressing force was developed. The following properties of the modified concrete were tested: compressive strength, water absorption, freeze-thaw resistance, scaling resistance in the presence of de-icing agents, chloride migration, resistance to CO2 and corrosion in aggressive solutions. Corrosion resistance was tested alternately in 1.8% solutions of NH4Cl, MgSO4, (NH2)2CO and CaCl2, which were altered every 7 days; the experiment lasted 9.5 months. Optimum compaction parameters in semi-industrial conditions were determined: ratio between piston stress (Qp ) and external top vibrator force (Po ) in the range 0.4÷-0.5 external top vibrator force 4 kN. High strength concretes with compressive strength fcm = 60÷70 MPa, very low water absorption (barrier formed in pores of cement hydrates against dioxide and chloride ions. Concrete specimens containing AP 4% c.m. and consolidated by vibro-vibropressing method proved to be practically resistant to highly corrosive environment. Vibro-vibropressing compaction technology of concrete modified with AP can be applied in prefabrication plants to produce elements for road, bridge and hydraulic engineering constructions.

Epigenetic Modifications and Diabetic Retinopathy

Directory of Open Access Journals (Sweden)

Renu A. Kowluru

2013-01-01

Full Text Available Diabetic retinopathy remains one of the most debilitating chronic complications, but despite extensive research in the field, the exact mechanism(s responsible for how retina is damaged in diabetes remains ambiguous. Many metabolic pathways have been implicated in its development, and genes associated with these pathways are altered. Diabetic environment also facilitates epigenetics modifications, which can alter the gene expression without permanent changes in DNA sequence. The role of epigenetics in diabetic retinopathy is now an emerging area, and recent work has shown that genes encoding mitochondrial superoxide dismutase (Sod2 and matrix metalloproteinase-9 (MMP-9 are epigenetically modified, activates of epigenetic modification enzymes, histone lysine demethylase 1 (LSD1, and DNA methyltransferase are increased, and the micro RNAs responsible for regulating nuclear transcriptional factor and VEGF are upregulated. With the growing evidence of epigenetic modifications in diabetic retinopathy, better understanding of these modifications has potential to identify novel targets to inhibit this devastating disease. Fortunately, the inhibitors and mimics targeted towards histone modification, DNA methylation, and miRNAs are now being tried for cancer and other chronic diseases, and better understanding of the role of epigenetics in diabetic retinopathy will open the door for their possible use in combating this blinding disease.

High-current heavy-ion accelerator system and its application to material modification

International Nuclear Information System (INIS)

Kishimoto, Naoki; Takeda, Yoshihiko; Lee, C.G.; Umeda, Naoki; Okubo, Nariaki; Iwamoto, Eiji

2001-01-01

A high-current heavy-ion accelerator system has been developed to realize intense particle fluxes for material modification. The facility of a tandem accelerator attained 1 mA-class ion current both for negative low-energy ions and positive high-energy ions. The negative ion source of the key device is of the plasma-sputter type, equipped with mutli-cusp magnets and Cs supply. The intense negative ions are either directly used for material irradiation at 60 keV or further accelerated up to 6 MeV after charge transformation. Application of negative ions, which alleviates surface charging, enables us to conduct low-energy high-current irradiation on insulating substrates. Since positive ions above the MeV range are irrelevant for Coulomb repulsion, the facility as a whole meets the needs of high-current irradiation onto insulators over a wide energy range. Application of high flux ions provides technological merits not only for efficient implantation but also for essentially different material kinetics, which may become an important tool of material modification. Other advantages of the system are co-irradiation by intense laser and in-situ detection of kinetic processes. For examples of material modifications, we present nanoparticle fabrication in insulators, and synergistic phenomena by co-irradiation due to ions and photons. (author)

Recent advances on Zeolite modification for direct alcohol fuel cells (DAFCs)

Science.gov (United States)

Makertihartha, I. G. B. N.; Zunita, M.; Rizki, Z.; Dharmawijaya, P. T.

2017-03-01

The increase of energy demand and global warming issues has driven studies of alternative energy sources. The polymer electrolyte membrane fuel cell (PEMFC) can be an alternative energy source by (partially) replacing the use of fossil fuel which is in line with the green technology concept. However, the usage of hydrogen as a fuel has several disadvantages mainly transportation and storage related to its safety aspects. Recently, alcohol has gained attention as an energy source for fuel cell application, namely direct alcohol fuel cell (DAFC). Among alcohols, high-mass energy density methanol and ethanol are widely used as direct methanol fuel cell (DMFC) and direct ethanol fuel cell (DEFC), respectively. Currently, the performance of DMFC is still rudimentary. Furthermore, the use of ethanol gives some additional privileges such as non-toxic property, renewable, ease of production in great quantity by the fermentation of sugar-containing raw materials. Direct alcohol fuel cell (DAFC) still has weakness in the low proton conductivity and high alcohol crossover. Therefore, to increase the performance of DAFC, modification using zeolite has been performed to improve proton conductivity and decrease alcohol crossover. Zeolite also has high thermal resistance properties, thereby increasing DAFC performance. This paper will discuss briefly about modification of catalyst and membrane for DAFC using zeolite. Zeolite modification effect on fuel cell performance especially proton conductivity and alcohol crossover will be presented in detail.

Study of Textile Surface Characteristic Modification by Using Electron Beam Radiation

International Nuclear Information System (INIS)

Iswani Gitawati; Rany Saptaaji

2007-01-01

The success of accelerator technology application in various field of industry, medical and pharmacy, environment, agricultural, food increase each year as the increasing of people needs, not excepted for surface treatment of fibers and textiles in textile industry. This writing aim is to asses the application of electron beam accelerator for textile surface treatment on finishing step. Surface treatment was done with electron beam low energy (100 - 500 keV), and because of its low penetration it was suitable used to gain the improvement of chemical, physical and mechanical properties of textile surface such as adhesion, wettability, printability, dyes-intake, crease recovery, wrinkle-resistance, flammability, abrasion resistance, soil and stain release to get better result. Modification of fibers and textiles surface properties on finishing process can be caused by crosslinking, grafting and degradation reactions. The assesment results showed that the greatest impact on commercial application of radiation in textiles were crease recovery and surface modification of wetting properties (soil and stain release). The radiation dose used for those purposes were 5 - 50 kGy. The bach process of graft textiles surface modification before and after irradiation by Co-60 source (gamma energies of 1.33 and 1.17 MeV) and continue process by electron beam were presented. The assesment results were reported in this paper. (author)

Valor y sentido del conocimiento en las órdenes mendicantes del Siglo XIII - doi: 10.4025/actascieduc.v32i2.9775

Directory of Open Access Journals (Sweden)

Gerald Cresta

2010-12-01

Full Text Available El Siglo XIII se expresa por medio de un concepto propio de la Universidad en que todo el saber debía estar orientado a la sapientia sacrae paginae, que fue expresada por la teología. Esta cuestión representaba sin duda un ideal de la Iglesia, pero asimismo un desafío especulativo para los pensadores de entonces. Con la complejidad epistemológica heredada del siglo XII y la inserción de las órdenes mendicantes en la labor académica, principalmente dominicos y franciscanos, esta fase de la historia de las ideas asistía a un antagonismo fundamental: el naturalismo de la herencia clásica -junto con el aporte del pensamiento árabe- y el humanismo cristiano se disputan la explicación del fin último del hombre. El valor y el sentido del conocimiento dependería en gran medida de la respuesta dada a esta diversidad de orientaciones. Y si bien es un hecho clave la influencia de los grandes autores antiguos, aristotelismo y neoplatonismo no son prerrogativa de una y otra orden. En los escritos de Santo Tomás está presente el neoplatonismo y es asimismo significativa la orientación empírica de la escuela franciscana en Inglaterra. Unos y otros, sin embargo, concordarían en una unidad del saber que podríamos interpretar bajo el signo de los trascendentales del ser. 

Designing Collaboration: How to Prepare SOF Augmentation Teams for Assignment to a U.S. Embassy Country Team

Science.gov (United States)

2014-06-01

Customs Enforcement ICS Integrated Country Strategy ICT information communications technology ILE intermediate level education xiii IMS...Competition Competing interests often exist between organizations. Loyalties to the organizations or self-interests supersede any other common purpose...environment. This can be as simple as taking colleagues out for coffee or hosting a working luncheon at a restaurant outside of the embassy. This allows the

New technologies in agricultural biotechnology

Directory of Open Access Journals (Sweden)

Andras Szekacs

2016-12-01

Full Text Available Technologies that emerged during the last decade as new tools occasionally represent fundamentally new means of genome modification, which, in addition to the scientific novelty, faces legislators with new challenge by giving a new meaning to both the biochemical/molecular biological and legal meaning to genetically modified organisms (GMOs. Emerging plant genetic technologies are categorized as zinc finger nuclease (ZFN technology; oligonucleotide directed mutagenesis; cisgenesis and intragenesis; RNA-dependent DNA methylation by RNA interference; grafting on GM rootstock; reverse breeding; agro-infiltration; and synthetic genomics. Although all these methods apply biotechnology processes to create new plant varieties, it debated whether all result in GMOs according to the current legal definition. Official risk assessment of these technologies is a task of outstanding weight of the authority.

Seaweed hydrocolloid production: an update on enzyme assisted extraction and modification technologies.

Science.gov (United States)

Rhein-Knudsen, Nanna; Ale, Marcel Tutor; Meyer, Anne S

2015-05-27

Agar, alginate, and carrageenans are high-value seaweed hydrocolloids, which are used as gelation and thickening agents in different food, pharmaceutical, and biotechnological applications. The annual global production of these hydrocolloids has recently reached 100,000 tons with a gross market value just above US$ 1.1 billion. The techno-functional properties of the seaweed polysaccharides depend strictly on their unique structural make-up, notably degree and position of sulfation and presence of anhydro-bridges. Classical extraction techniques include hot alkali treatments, but recent research has shown promising results with enzymes. Current methods mainly involve use of commercially available enzyme mixtures developed for terrestrial plant material processing. Application of seaweed polysaccharide targeted enzymes allows for selective extraction at mild conditions as well as tailor-made modifications of the hydrocolloids to obtain specific functionalities. This review provides an update of the detailed structural features of κ-, ι-, λ-carrageenans, agars, and alginate, and a thorough discussion of enzyme assisted extraction and processing techniques for these hydrocolloids.

Genetic modification of cells for transplantation.

Science.gov (United States)

Lai, Yi; Drobinskaya, Irina; Kolossov, Eugen; Chen, Chunguang; Linn, Thomas

2008-01-14

Progress in gene therapy has produced promising results that translate experimental research into clinical treatment. Gene modification has been extensively employed in cell transplantation. The main barrier is an effective gene delivery system. Several viral vectors were utilized in end-stage differentiated cells. Recently, successful applications were described with adenovirus-associated vectors. As an alternative, embryonic stem cell- and stem cell-like systems were established for generation of tissue-specified gene-modified cells. Owing to the feasibility for genetic manipulations and the self-renewing potency of these cells they can be used in a way enabling large-scale in vitro production. This approach offers the establishment of in vitro cell culture systems that will deliver sufficient amounts of highly purified, immunoautologous cells suitable for application in regenerative medicine. In this review, the current technology of gene delivery systems to cells is recapitulated and the latest developments for cell transplantation are discussed.

Cis-, intra-, subgenesis, genome editing as modern technologies for modifying the crop genomes (review

Directory of Open Access Journals (Sweden)

Н. Е. Волкова

2016-02-01

Full Text Available Purpose. Reviewing the literature on modern technologies of genetic modification of crop genomes. Results. The current state of genetically modified plants creation is analyzed. The information on cis-, intra- and subgenic plants and their comparison with transgenic crops is given. Examples of cis- and intragenesis application for improving characteristics of crops are provided. Such state-of-the-art technology of crop genome modification as genome editing is considered. Conclusions. Technologies for producing cis-, intra-, subgenic plants are rapidly developing and resulting in crops of the 21st century that can solve the problem of food provision for a constantly growing world population with the least contrary to the public interest.

Proteomic analysis of post-translational modifications

DEFF Research Database (Denmark)

Mann, Matthias; Jensen, Ole N

2003-01-01

Post-translational modifications modulate the activity of most eukaryote proteins. Analysis of these modifications presents formidable challenges but their determination generates indispensable insight into biological function. Strategies developed to characterize individual proteins are now...... systematically applied to protein populations. The combination of function- or structure-based purification of modified 'subproteomes', such as phosphorylated proteins or modified membrane proteins, with mass spectrometry is proving particularly successful. To map modification sites in molecular detail, novel...

Chemical Modifications of Starch: Microwave Effect

OpenAIRE

Lewicka, Kamila; Siemion, Przemysław; Kurcok, Piotr

2015-01-01

This paper presents basic methods of starch chemical modification, the effect of microwave radiation on the modification process, and the physicochemical properties of starch. It has been shown that the modifications contribute to improvement of the material performance and likewise to significant improvement of its mechanical properties. As a result, more and more extensive use of starch is possible in various industries. In addition, methods of oxidized starch and starch esters preparation ...

Review of Trenchless Technologies' Successes and their ...

African Journals Online (AJOL)

... costly construction modifications, and use of substandard borrow material, environmental damage to the site, post construction remedial work, and even failure of a structure and subsequent litigation. Trenchless technology can be defined as the use of construction methods to install and repair underground infrastructure ...

Hybrid membrane using polyethersulfone-modification of multiwalled carbon nanotubes with silane agent to enhance high performance oxygen separation

Directory of Open Access Journals (Sweden)

Tutuk Djoko Kusworo

2014-04-01

Full Text Available Mixed matrix membrane comprising carbon nanotubes embedded in polymer matrix have become one of the emerging technologies. This study was investigated in order to study the effect of silane agent modification towards carbon nanotubes (CNT surface at different concentration on oxygen enrichment performances of asymmetric mixed matrix membrane. The modified carbon nanotubes were prepared by treating the carbon nanotubes with chemical modification using Dynasylan Ameo (DA silane agent to allow PES chains to be grafted on carbon nanotubes surface. The results from the FESEM, DSC and FTIR analysis confirmed that chemical modification on carbon nanotubes surface had taken place. Sieve-in-a-cage’ morphology observed shows the poor adhesion between polymer and unmodified CNT. The gas separation performance of the asymmetric flat sheet mixed matrix membranes with modified CNT were relatively higher compared to the unmodified CNT. Hence, coated hollow fiber mixed matrix membrane with chemical modification on CNT surface using (3-aminopropyl-triethoxy methyl silane agent can potentially enhance the gas separation performance of O2 and N2.

The surface modification of polystyrene

International Nuclear Information System (INIS)

Tremlett, C.

2000-03-01

Polymers have ideal bulk properties for many applications. However, adhesion to many polymers is poor without surface pretreatment. This can result, for example, in peeling paint and printing, adhesive joint failure and bio-incompatibility. In applications such as painting, printing, adhesive bonding and biocompatibility, various cleaning or surface chemical modifications may be employed. A commodity polymer where pretreatment is sometimes needed is polystyrene. This project investigated, in detail, the effects of a novel method of modification namely mediated electrochemical oxidation (MEO), as a mode of surface modification on polystyrene and a comparison was made with other polymers. The resulting modification was investigated using a range of surface analysis techniques to obtain complementary information. These included, X-ray photoelectron spectroscopy, contact angles, static secondary ion mass spectrometry, atomic force microscopy, chemical derivatization, scanning electron microscopy, attenuated total reflection Fourier Transform infrared spectroscopy and composite lap shear joint testing. It has been shown that MEO modifies the surface of polystyrene introduced oxygen mainly as hydroxyl groups, and a small number of carbonyl groups, that are positioned only on the backbone hydrocarbon chain. This modification improved adhesion, was stable and samples could be stored in aqueous media. The resulting hydroxylation was further derivatized using an amino acid to provide a specialised surface. This was very different from the multiple oxygen functionalities introduced in the comparison studies by UV/ozone and plasma treatments. (author)

PSA based plant modifications and back-fits

International Nuclear Information System (INIS)

1997-01-01

The mandate of Principal Working Group No. 5 - Risk Assessment states that 'The group should deal with the technology and methods for identifying contributors to risk and assessing their importance, and appropriate exchanges of information on current research'. Since being formulated in 1982, along with this mandate, the group has also endeavored to develop a common understanding of the different approaches taken in risk assessment. The focus of this report is to provide knowledge to experts on the role Probabilistic Safety Assessment (PSA) has had in safety decision making. PSA is a powerful tool for improving Nuclear Power Plant safety by identifying weaknesses in design or operation and setting priorities for plant modifications and back-fits. While the use is well recognised, it is also true that any safety decision is generally based on several elements, both probabilistic and deterministic. This document provides a general overview of insights gained from the representative set of examples collected from Member countries (Finland, France, Germany, Japan, Korea, Netherlands, Spain, Sweden, Switzerland, United Kingdom, United States). The report starts with basic types of plant modifications which were carried out (e.g. hardware or software, important or minor, etc.) and the characteristics of the PSAs used in the examples (e.g. level and scope, specific or generic, on-going or terminated, etc.). The insights gained from this small collection are then reviewed. The appendix gives a full text version of the Member country contributions

La Historia Roderici en su aspecto léxico: Estudio comparativo en relación con la Chronica Adefonsi Imperatoris y las crónicas hispanolatinas anteriores al siglo XIII

Directory of Open Access Journals (Sweden)

Estrella Pérez Rodríguez

2013-06-01

Full Text Available Este trabajo profundiza en el aspecto léxico de la Historia Roderici (y parcialmente también en el de la Chronica Adefonsi Imperatoris, teniendo como punto de comparación el resto de las crónicas hispanolatinas compuestas antes del siglo XIII. Se estudia la variedad del léxico empleado y su capacidad de innovación, dentro de la que se han identificado 66 términos no presentes en ninguna otra crónica hispana del período. El rastreo de estos vocablos en las fuentes medievales literarias europeas y en los diplomas hispanos ha llevado a observar que algunos no se utilizaron antes de finales del siglo XII, lo que apoya una fecha tardía para la obra. Asimismo el estudio ha permitido proponer alguna modificación en el texto editado de la Historia y también ha puesto en evidencia que su autor tenía un buen conocimiento del lenguaje notarial y procedía de la parte oriental de Hispania, muy posiblemente de la ya apuntada Nájera.Cet article présente une étude lexicale de l’Historia Roderici (et aussi partiellement de la Chronica Adefonsi imperatoris et la compare avec les autres chroniques hispaniques écrites avant le XIIIe siècle. Il souligne la richesse lexicale de l'œuvre, puisque l’Historia emploie 66 mots qui ne se trouvent pas ailleurs dans la production historiographique des royaumes espagnols de cette époque. L’auteur a étudié l’emploi de ces mots dans les textes littéraires écrits hors de la Péninsule Ibérique et dans les documents hispaniques et a vérifié que quelques uns n’apparaissent qu’à la fin du XIIe siècle. Ce résultat indique qu’une date de composition tardive de l’Historia est vraisemblable. L’étude propose aussi des modifications du texte de l’Historia tel qu'il a été édité jusqu'à présent, et démontre que l'auteur connaissait bien le langage notarial et qu’il était originaire de la partie orientale de l’Espagne, probablement de Nájera, comme on l'avait déjà avancé.

Pragmatic Graph Rewriting Modifications

OpenAIRE

Rodgers, Peter; Vidal, Natalia

1999-01-01

We present new pragmatic constructs for easing programming in visual graph rewriting programming languages. The first is a modification to the rewriting process for nodes the host graph, where nodes specified as 'Once Only' in the LHS of a rewrite match at most once with a corresponding node in the host graph. This reduces the previously common use of tags to indicate the progress of matching in the graph. The second modification controls the application of LHS graphs, where those specified a...

Drug Addiction and DNA Modifications.

Science.gov (United States)

Brown, Amber N; Feng, Jian

2017-01-01

Drug addiction is a complex disorder which can be influenced by both genetic and environmental factors. Research has shown that epigenetic modifications can translate environmental signals into changes in gene expression, suggesting that epigenetic changes may underlie the causes and possibly treatment of substance use disorders. This chapter will focus on epigenetic modifications to DNA, which include DNA methylation and several recently defined additional DNA epigenetic changes. We will discuss the functions of DNA modifications and methods for detecting them, followed by a description of the research investigating the function and consequences of drug-induced changes in DNA methylation patterns. Understanding these epigenetic changes may provide us translational tools for the diagnosis and treatment of addiction in the future.

Methodological guidelines for developing accident modification functions

DEFF Research Database (Denmark)

Elvik, Rune

2015-01-01

This paper proposes methodological guidelines for developing accident modification functions. An accident modification function is a mathematical function describing systematic variation in the effects of road safety measures. The paper describes ten guidelines. An example is given of how to use...... limitations in developing accident modification functions are the small number of good evaluation studies and the often huge variation in estimates of effect. It is therefore still not possible to develop accident modification functions for very many road safety measures. © 2015 Elsevier Ltd. All rights...... the guidelines. The importance of exploratory analysis and an iterative approach in developing accident modification functions is stressed. The example shows that strict compliance with all the guidelines may be difficult, but represents a level of stringency that should be strived for. Currently the main...

Technology and equipment to improve reliability of pipeline transport

Science.gov (United States)

Suleimanov, D. F.; Shulayev, N. S.; Bondar, K. E.; Laponov, S. V.; Uzinger, A. A.

2017-10-01

The article is dedicated to development of technology and hardware design of method pipeline transport reliability improving by improving the isolated coating properties modified by microwave radiation. The article describes the technology of the modification process of the coating and instrumentation production, which allows improving operational properties not only in stationary conditions in the manufacture of the insulation coating, but also during its replacement in the field.

Biomedical applications using low temperature plasma technology

International Nuclear Information System (INIS)

Dai Xiujuan; Jiang Nan

2006-01-01

Low temperature plasma technology and biomedicine are two different subjects, but the combination of the two may play a critical role in modern science and technology. The 21 st century is believed to be a biotechnology century. Plasma technology is becoming a widely used platform for the fabrication of biomaterials and biomedical devices. In this paper some of the technologies used for material surface modification are briefly introduced. Some biomedical applications using plasma technology are described, followed by suggestions as to how a bridge between plasma technology and biomedicine can be built. A pulsed plasma technique that is used for surface functionalization is discussed in detail as an example of this kind of bridge or combination. Finally, it is pointed out that the combination of biomedical and plasma technology will be an important development for revolutionary 21st century technologies that requires different experts from different fields to work together. (authors)

Direct modification of silicon surface by nanosecond laser interference lithography

Energy Technology Data Exchange (ETDEWEB)

Wang, Dapeng [JR3CN and CNM (Changchun University of Science and Technology), Changchun 130022 (China); JR3CN and IRAC (University of Bedfordshire), Luton LU1 3JU (United Kingdom); Wang, Zuobin, E-mail: wangz@cust.edu.cn [JR3CN and CNM (Changchun University of Science and Technology), Changchun 130022 (China); JR3CN and IRAC (University of Bedfordshire), Luton LU1 3JU (United Kingdom); Zhang, Ziang [JR3CN and CNM (Changchun University of Science and Technology), Changchun 130022 (China); Yue, Yong [JR3CN and CNM (Changchun University of Science and Technology), Changchun 130022 (China); JR3CN and IRAC (University of Bedfordshire), Luton LU1 3JU (United Kingdom); Li, Dayou [JR3CN and IRAC (University of Bedfordshire), Luton LU1 3JU (United Kingdom); Maple, Carsten [JR3CN and CNM (Changchun University of Science and Technology), Changchun 130022 (China); JR3CN and IRAC (University of Bedfordshire), Luton LU1 3JU (United Kingdom)

2013-10-01

Periodic and quasi-periodic structures on silicon surface have numerous significant applications in photoelectronics and surface engineering. A number of technologies have been developed to fabricate the structures in various research fields. In this work, we take the strategy of direct nanosecond laser interference lithography technology, and focus on the silicon material to create different well-defined surface structures based on theoretical analysis of the formation of laser interference patterns. Two, three and four-beam laser interference systems were set up to fabricate the grating, regular triangle and square structures on silicon surfaces, respectively. From the AFM micrographs, the critical features of structures have a dependence on laser fluences. For a relative low laser fluence, grating and dot structures formed with bumps due to the Marangoni Effect. With the increase of laser fluences, melt and evaporation behaviors can be responsible for the laser modification. By properly selecting the process parameters, well-defined grating and dot structures can been achieved. It can be demonstrated that direct laser interference lithography is a facile and efficient technology with the advantage of a single process procedure over macroscale areas for the fabrication of micro and nano structures.

Acceptance of genetically modified foods: the relation between technology and evaluation.

Science.gov (United States)

Tenbült, Petra; De Vries, Nanne K; van Breukelen, Gerard; Dreezens, Ellen; Martijn, Carolien

2008-07-01

This study investigates why consumers accept different genetically modified food products to different extents. The study shows that whether food products are genetically modified or not and whether they are processed or not are the two important features that affect the acceptance of food products and their evaluation (in terms of perceived healthiness, naturalness, necessity and tastiness). The extent to which these evaluation attributes and acceptance of a product are affected by genetic modification or processing depends on whether the product is negatively affected by the other technology: Any technological change to a 'natural' product (when nonprocessed products are genetically modified or when non-genetically modified products are processed) affect evaluation and acceptance stronger than a change to an technologically adapted product (when processed products are also genetically modified or vice versa). Furthermore, evaluation attributes appear to mediate the effects of genetic modification and processing on acceptance.

Progress in ultrafast intense laser science XIII

CERN Document Server

III, Wendell; Paulus, Gerhard

2017-01-01

This thirteenth volume covers a broad range of topics from this interdisciplinary research field, focusing on atoms, molecules, and clusters interacting in intense laser field and high-order harmonics generation and their applications. The PUILS series delivers up-to-date reviews of progress in Ultrafast Intense Laser Science, the interdisciplinary research field spanning atomic and molecular physics, molecular science, and optical science, which has been stimulated by the recent developments in ultrafast laser technologies. Each volume compiles peer-reviewed articles authored by researchers at the forefront of each their own subfields of UILS. Every chapter opens with an overview of the topics to be discussed, so that researchers unfamiliar to the subfield, as well as graduate students, can grasp the importance and attractions of the research topic at hand; these are followed by reports of cutting-edge discoveries.   .

Directly thiolated modification onto the surface of detonation nanodiamonds.

Science.gov (United States)

Hsu, Ming-Hua; Chuang, Hong; Cheng, Fong-Yu; Huang, Ying-Pei; Han, Chien-Chung; Chen, Jiun-Yu; Huang, Su-Chin; Chen, Jen-Kun; Wu, Dian-Syue; Chu, Hsueh-Liang; Chang, Chia-Ching

2014-05-28

An efficient method for modifying the surface of detonation nanodiamonds (5 and 100 nm) with thiol groups (-SH) by using an organic chemistry strategy is presented herein. Thiolated nanodiamonds were characterized by spectroscopic techniques, and the atomic percentage of sulfur was analyzed by elemental analysis and X-ray photoelectron spectroscopy. The conjugation between thiolated nanodiamonds and gold nanoparticles was elucidated by transmission electron microscopy and UV-vis spectrometry. Moreover, the material did not show significant cytotoxicity to the human lung carcinoma cell line and may prospectively be applied in bioconjugated technology. The new method that we elucidated may significantly improve the approach to surface modification of detonation nanodiamonds and build up a new platform for the application of nanodiamonds.

Relative effects of plasma, fibrinogen concentrate, and factor XIII on ROTEM coagulation profiles in an in vitro model of massive transfusion in trauma.

Science.gov (United States)

Schmidt, David E; Halmin, Märit; Wikman, Agneta; Östlund, Anders; Ågren, Anna

2017-10-01

Massive traumatic haemorrhage is aggravated through the development of trauma-induced coagulopathy, which is managed by plasma transfusion and/or fibrinogen concentrate administration. It is yet unclear whether these treatments are equally potent in ensuring adequate haemostasis, and whether additional factor XIII (FXIII) administration provides further benefits. In this study, we compared ROTEM whole blood coagulation profiles after experimental massive transfusion with different transfusion regimens in an in vitro model of dilution- and transfusion-related coagulopathy. Healthy donor blood was mixed 1 + 1 with six different transfusion regimens. Each regimen contained RBC, platelet concentrate, and either fresh frozen plasma (FFP) or Ringer's acetate (RA). The regimens were further augmented through addition of a low- or medium-dose fibrinogen concentrate and FXIII. Transfusion with FFP alone was insufficient to maintain tissue-factor activated clot strength, coincidental with a deficiency in fibrin-based clot strength. Fibrinogen concentrate conserved, but did not improve coagulation kinetics and overall clot strength. Only combination therapy with FFP and low-dose fibrinogen concentrate improved both coagulation kinetics and fibrin-based clot strength. Administration of FXIII did not result in an improvement of clot strength. In conclusion, combination therapy with both FFP and low-dose fibrinogen concentrate improved clotting time and produced firm clots, representing a possible preferred first-line regimen to manage trauma-induced coagulopathy when RBC and platelets are also transfused. Further research is required to identify optimal first-line transfusion fluids for massive traumatic haemorrhage.

Seaweed Hydrocolloid Production: An Update on Enzyme Assisted Extraction and Modification Technologies

Directory of Open Access Journals (Sweden)

Nanna Rhein-Knudsen

2015-05-01

Full Text Available Agar, alginate, and carrageenans are high-value seaweed hydrocolloids, which are used as gelation and thickening agents in different food, pharmaceutical, and biotechnological applications. The annual global production of these hydrocolloids has recently reached 100,000 tons with a gross market value just above US$ 1.1 billion. The techno-functional properties of the seaweed polysaccharides depend strictly on their unique structural make-up, notably degree and position of sulfation and presence of anhydro-bridges. Classical extraction techniques include hot alkali treatments, but recent research has shown promising results with enzymes. Current methods mainly involve use of commercially available enzyme mixtures developed for terrestrial plant material processing. Application of seaweed polysaccharide targeted enzymes allows for selective extraction at mild conditions as well as tailor-made modifications of the hydrocolloids to obtain specific functionalities. This review provides an update of the detailed structural features of κ-, ι-, λ-carrageenans, agars, and alginate, and a thorough discussion of enzyme assisted extraction and processing techniques for these hydrocolloids.

Surface modifications induced by pulsed-laser texturing—Influence of laser impact on the surface properties

Energy Technology Data Exchange (ETDEWEB)

Costil, S., E-mail: sophie.costil@utbm.fr [IRTES-LERMPS, Université de Technologie de Belfort - Montbéliard, site de Sévenans, 90010 Belfort Cedex (France); Lamraoui, A.; Langlade, C. [IRTES-LERMPS, Université de Technologie de Belfort - Montbéliard, site de Sévenans, 90010 Belfort Cedex (France); Heintz, O.; Oltra, R. [ICB, Université de Bourgogne, 21078 Dijon Cedex (France)

2014-01-01

Laser cleaning technology provides a safe, environmentally friendly and very cost effective way to improve cleaning and surface preparation of metallic materials. Compared with efficient cleaning processes, it can avoid the disadvantages of ductile materials prepared by conventional technologies (cracks induced by sand-blasting for example) and treat only some selected areas (due to the optical fibers). By this way, laser technology could have several advantages and expand the range of thermal spraying. Moreover, new generations of lasers (fiber laser, disc laser) allow the development of new methods. Besides a significant bulk reduction, no maintenance, low operating cost, laser fibers can introduce alternative treatments. Combining a short-pulse laser with a scanner allows new applications in terms of surface preparation. By multiplying impacts using scanning laser, it is possible to shape the substrate surface to improve the coating adhesion as well as the mechanical behaviour. In addition, during the interactions of the laser beam with metallic surfaces, several modifications can be induced and particularly thermal effects. Indeed, under ambient conditions, a limited oxidation of the clean surface can occur. This phenomenon has been investigated in detail for silicon but few works have been reported concerning metallic materials. This paper aims at studying the surface modifications induced on aluminium alloy substrates after laser texturing. After morphological observations (SEM), a deeper surface analysis will be performed using XPS (X-ray photoelectron spectroscopy) measures and microhardness testing.

The computational nature of memory modification.

Science.gov (United States)

Gershman, Samuel J; Monfils, Marie-H; Norman, Kenneth A; Niv, Yael

2017-03-15

Retrieving a memory can modify its influence on subsequent behavior. We develop a computational theory of memory modification, according to which modification of a memory trace occurs through classical associative learning, but which memory trace is eligible for modification depends on a structure learning mechanism that discovers the units of association by segmenting the stream of experience into statistically distinct clusters (latent causes). New memories are formed when the structure learning mechanism infers that a new latent cause underlies current sensory observations. By the same token, old memories are modified when old and new sensory observations are inferred to have been generated by the same latent cause. We derive this framework from probabilistic principles, and present a computational implementation. Simulations demonstrate that our model can reproduce the major experimental findings from studies of memory modification in the Pavlovian conditioning literature.

Modifications to nuclear power plants. Safety guide

International Nuclear Information System (INIS)

2004-01-01

This Safety Guide was prepared under the IAEA's programme for safety standards for nuclear power plants. It supplements Section 7 of the Safety Requirements publication on Safety of Nuclear Power Plants: Operation, which establishes the safety requirements for the modification of nuclear power plants. Reasons for carrying out modifications to nuclear power plants may include: (1) maintaining or strengthening existing safety provisions and thus maintaining consistency with or improving on the current design. (2) recovering from plant faults. (3) improving the thermal performance or increasing the power rating of the plant. (4) increasing the maintainability of the plant, reducing the radiation exposure of personnel or reducing the costs of plant maintenance. And (5) extending the design life of the plant. Most modifications, made on the basis of operating experience, are intended to improve on the design or to improve operational performance and flexibility. Some are rendered necessary by new regulatory requirements, ageing of the plant or obsolescence of equipment. However, the benefits of regularly updating the plant design can be jeopardized if modifications are not kept under rigorous control throughout the lifetime of the plant. The need to reduce costs and improve efficiency, in combination with changes to the structure of the electricity generation sector of the economy in many countries, has led many companies to make changes in the structure of the operating organization for nuclear power plants. Whatever the reason for such organizational changes, consideration should be given to the effects of those changes with the aim of ensuring that they would have no impacts that would compromise the safety of the plant. The objective of this Safety Guide is to provide guidance and recommendations on controlling activities relating to modifications at nuclear power plants in order to reduce risk and to ensure that the configuration of the plant is at all times under

Modifications to nuclear power plants. Safety guide

International Nuclear Information System (INIS)

2007-01-01

This Safety Guide was prepared under the IAEA's programme for safety standards for nuclear power plants. It supplements Section 7 of the Safety Requirements publication on Safety of Nuclear Power Plants: Operation, which establishes the safety requirements for the modification of nuclear power plants. Reasons for carrying out modifications to nuclear power plants may include: (1) maintaining or strengthening existing safety provisions and thus maintaining consistency with or improving on the current design. (2) recovering from plant faults. (3) improving the thermal performance or increasing the power rating of the plant. (4) increasing the maintainability of the plant, reducing the radiation exposure of personnel or reducing the costs of plant maintenance. And (5) extending the design life of the plant. Most modifications, made on the basis of operating experience, are intended to improve on the design or to improve operational performance and flexibility. Some are rendered necessary by new regulatory requirements, ageing of the plant or obsolescence of equipment. However, the benefits of regularly updating the plant design can be jeopardized if modifications are not kept under rigorous control throughout the lifetime of the plant. The need to reduce costs and improve efficiency, in combination with changes to the structure of the electricity generation sector of the economy in many countries, has led many companies to make changes in the structure of the operating organization for nuclear power plants. Whatever the reason for such organizational changes, consideration should be given to the effects of those changes with the aim of ensuring that they would have no impacts that would compromise the safety of the plant. The objective of this Safety Guide is to provide guidance and recommendations on controlling activities relating to modifications at nuclear power plants in order to reduce risk and to ensure that the configuration of the plant is at all times under

Enhancement of H2-sensing Properties of F-doped SnO2 Sensorby Surface Modification with SiO2

Directory of Open Access Journals (Sweden)

S. P. Khatkar

2006-05-01

Full Text Available Effects of surface chemical modification with sodium silicate on the gas-sensingproperties of F-doped SnO2 gas sensor designed and fabricated employing micro-electromechanical system (MEMS technology were investigated. Gas sensing properties of thesensor were checked against combustible gases like H2, CO, CH4 and C3H8 at a heatervoltage of 0.7 V. The H2 sensitivity of the surface modified F-doped SnO2 micro sensormarkedly increased and reached S = 175 which was found to be about 40 times more thanthat of unmodified sensor (S = ~ 4.2. The increase in the sensitivity is discussed in terms ofincreased resistivity and reduced permeation of gaseous oxygen into the underlying sensinglayer due to the surface modification of the sensor. The present micro-hydrogen sensor withenhanced sensitivity due to SiO2 incorporation is a low energy consuming portable sensormodule that can be mass-produced using MEMS technology at low cost.

Histone modifications: Cycling with chromosomal replication

DEFF Research Database (Denmark)

Thon, Genevieve

2008-01-01

Histone modifications tend to be lost during chromosome duplication. Several recent studies suggest that the RNA interference pathway becomes active during the weakened transcriptional repression occurring at centromeres in S phase, resulting in the re-establishment of histone modifications...

Process of Judging Significant Modifications for Different Transportation Systems compared to the Approach for Nuclear Installations

Directory of Open Access Journals (Sweden)

Nicolas Petrek

2015-12-01

Full Text Available The implementation of the CSM regulation by the European Commission in 2009 which harmonizes the risk assessment process and introduces a rather new concept of judging changes within the European railway industry. This circumstance has risen the question how other technology sectors handle the aspect of modifications and alterations. The paper discusses the approaches for judging the significance of modifications within the three transport sectors of European railways, aviation and maritime transportation and the procedure which is used in the area of nuclear safety. We will outline the similarities and differences between these four methods and discuss the underlying reasons. Finally, we will take into account the role of the European legislator and the fundamental idea of a harmonization of the different approaches.

Hollywood's Conversion to Color: The Technological, Economic and Aesthetic Factors.

Science.gov (United States)

Kindem, Forham A.

1979-01-01

Discusses the film industry's conversion to color cinematography in the period between the 1920s and 1960s. Cites economic considerations, technological modifications, and aesthetic preferences by audiences as factors in this development. (JMF)

ARSENIC REMOVAL FROM DRINKING WATER BY PROCESS MODIFICATION TO COAGULATION/FILTRATION. USEPA DEMONSTRATION PROJECT AT LIDGERWOOD, ND. FINAL PERFORMANCE EVALUATION REPORT

Science.gov (United States)

This report documents the activities performed and the results obtained for the arsenic removal treatment technology demonstration project at the Lidgerwood, North Dakota site. The objectives of the project were to evaluate: (1) the effectiveness of process modifications to an e...

75 FR 41529 - Petitions for Modification

Science.gov (United States)

2010-07-16

... application of existing mandatory safety standards published in Title 30 of the Code of Federal Regulations... DEPARTMENT OF LABOR Mine Safety and Health Administration Petitions for Modification AGENCY: Mine Safety and Health Administration (MSHA), Labor. ACTION: Notice of petitions for modification of existing...

75 FR 29784 - Petitions for Modification

Science.gov (United States)

2010-05-27

... application of existing mandatory safety standards published in Title 30 of the Code of Federal Regulations... DEPARTMENT OF LABOR Mine Safety and Health Administration Petitions for Modification AGENCY: Mine Safety and Health Administration (MSHA), Labor. ACTION: Notice of petitions for modification of existing...

75 FR 34486 - Petitions for Modification

Science.gov (United States)

2010-06-17

... application of existing mandatory safety standards published in Title 30 of the Code of Federal Regulations... DEPARTMENT OF LABOR Mine Safety and Health Administration Petitions for Modification AGENCY: Mine Safety and Health Administration (MSHA), Labor. ACTION: Notice of petitions for modification of existing...

Post-Translational Modifications of TRP Channels

Directory of Open Access Journals (Sweden)

Olaf Voolstra

2014-04-01

Full Text Available Transient receptor potential (TRP channels constitute an ancient family of cation channels that have been found in many eukaryotic organisms from yeast to human. TRP channels exert a multitude of physiological functions ranging from Ca2+ homeostasis in the kidney to pain reception and vision. These channels are activated by a wide range of stimuli and undergo covalent post-translational modifications that affect and modulate their subcellular targeting, their biophysical properties, or channel gating. These modifications include N-linked glycosylation, protein phosphorylation, and covalent attachment of chemicals that reversibly bind to specific cysteine residues. The latter modification represents an unusual activation mechanism of ligand-gated ion channels that is in contrast to the lock-and-key paradigm of receptor activation by its agonists. In this review, we summarize the post-translational modifications identified on TRP channels and, when available, explain their physiological role.

Continuous modification of AK11 silumin with multicomponent salt on base of NaCl

Directory of Open Access Journals (Sweden)

J. Pezda

2007-12-01

Full Text Available Sodium belongs to the most effective modifying agents. The sodium can be brought into metal bath in metallic form or in form of chemical compounds comprising sodium, the most often in form of NaF. In the both above mentioned cases action of sodium is of very short duration, (what constitutes its main disadvantage, as lasting for about 15-20 minutes, mainly due to its evaporation from metal bath.Prolongation of modifying agent’s action can be accomplished due to technology of continuous introduction of sodium to metal bath. That technology is based on continuous electrolysis of sodium salt, occurring directly in melting pot with liquid alloy. Application of solid electrolyte – conducting sodium ions (ionic conductance – and simultaneously maintaining solid state of aggregation in melting and superheating temperature of alloy, i.e. 600÷800°C is indispensable for such process. Suitable sodium salt which is placed in retort produced from solid electrolyte shall undergo dissociation, and next electrolysis, in result of applied direct current. Sodium ions arisen during the dissociation of sodium salts and electrolysis are “conveyed” through retort walls made from solid electrolyte. In contact with liquid alloy as cathode, sodium ions pass to atomic state, modifying the alloy. The paper discusses results of initial study concerning process of continuous modification of AK11 silumin with use of multicomponent sodium salt on base of NaCl, shows results of tensile strength Rm and measurement of voltage drop for the alloy in solid state. Values of those parameters have confirmed obtained modification effect of investigated alloys. Assurance of stable run of continuous modification process brings about necessity of a further research aimed at optimization of parameters of the process.

Modifications at operating nuclear power plants

International Nuclear Information System (INIS)

Duffy, T.J.; Gazda, P.A.

1985-01-01

Modifications at operating nuclear power plants offer the structural engineer many challenges in the areas of scheduling of work, field adjustments, and engineering staff planning. The scheduling of structural modification work for operating nuclear power plants is normally closely tied to planned or unplanned outages of the plant. Coordination between the structural engineering effort, the operating plant staff, and the contractor who will be performing the modifications is essential to ensure that all work can be completed within the allotted time. Due to the inaccessibility of some areas in operating nuclear power plants or the short time available to perform the structural engineering in the case of an unscheduled outrage, field verification of a design is not always possible prior to initiating the construction of the modification. This requires the structural engineer to work closely with the contractor to promptly resolve problems due to unanticipated interferences or material procurement problems that may arise during the course of construction. The engineering staff planning for structural modifications at an operating nuclear power plant must be flexible enough to permit rapid response to the common ''fire drills,'' but controlled enough to ensure technically correct designs and to minimize the expenditure of man-hours and the resulting engineering cost

Modification of the IAN-R1 reactor

International Nuclear Information System (INIS)

Jaime, J.; Ahumada, S.; Spin, R.A.

1990-01-01

The IAN-R1 reactor is the only nuclear reactor operating in Colombia; it is installed at the Institute of Nuclear Affairs (AIN) in Bogota, which is an official body coming under the Ministry of Mining and Energy. This reactor started operation in January 1965 with a rated power of 10 kW and was modified a year later to operate at 20 kW, which has been its rated power up to the present. Given its importance for the application of nuclear technology in Columbia for various purposes, principally in the areas of neutron activation analysis, determination of uranium content in minerals using the delayed neutron counting method, production of certain radioisotopes such as 198 Au and 82 Br for engineering applications, and production of radioactive material for teaching and research purposes, research has been in progress for some years into ways of increasing its power. The study on experimental requirements and on the demand for locally produced radioisotopes came to the conclusion that its power should be increased to 1000 kW, which would allow the facility to remain on the same site. The modification includes conversion of the core to low-enriched fuel, operation up to 1 MW, modification of the shielding, renovation of instrumentation and installation of a radioisotope processing plant. When the reactor is modified we will be able to produce other radioisotopes for applications in nuclear medicine, industry and engineering; at the same time, the safety of the facility will be optimized and the experimental facilities improved

Standard approach to plant modifications

International Nuclear Information System (INIS)

Mecredy, R.C.

1988-01-01

Organizational and management approaches to the design, installation, and turnover of nuclear plant modifications have changed dramatically in the last 10 to 15 yr. In response to these changes, organizational and individual responsibilities have been defined and management systems have been established at Rochester Gas and Electric (RG and E) Corporation to ensure that high-quality plant modifications are installed in a timely manner that satisfies user needs at minimal cost

Radiation processing of polymers and semiconductors at the Institute of Nuclear Chemistry and Technology

International Nuclear Information System (INIS)

Zimek, Z.; Przybytniak, G.; Kaluska, I.

2006-01-01

R(and)D studies in the field of radiation technology in Poland are mostly concentrated at the Institute of Nuclear Chemistry and Technology (INCT). The results of the INCT works on polymer and semiconductor modification have been implemented in various branches of national economy, particularly in industry and medicine. Radiation technology for polymer modification was implemented in the middle of the 1970-ties. Among others, the processes of irradiation and heat shrinkable products expansion have been developed. The transfer of this technology to Polish industry was performed in the middle of the 1980-ties. The present study aims at the formulation of new PE composites better suited to new generation of heat shrinkable products, for example, a new generation of hot-melt adhesives has been developed to meet specific requirements of customers. Modified polypropylene was used for the production of medical devices sterilized by radiation, especially disposable syringes, to overcome the low radiation resistance of the basic material. Modified polypropylene (PP-M) has been formulated at the INCT to provide material suitable for medical application and radiation sterilization process. Modification of semiconductor devices by EB was applied on an industrial scale since 1978 when the INCT and the LAMINA semiconductor factory successfully adopted that technology to improve specific semiconductor devices. This activity is continued on commercial basis where the INCT facilities served to contract irradiation of certain semiconductor devices according to the manufacturing program of the Polish factory and customers from abroad. (author)

Radiation processing technology in Malaysia

International Nuclear Information System (INIS)

Khairul Zaman Hj Mohd Dahlan

2004-01-01

Radiation processing technology is widely used in industry to enhance efficiency and productivity, improve product quality and competitiveness. Efforts have been made by MINT to expand the application of radiation processing technology for modification of indigenous materials such as natural rubber and rubber based products, palm oil and palm oil based products and polysaccharide into new and high value added products. This paper described MINT experiences on developing products through R and D from the laboratory to the pilot plant stage and commercialization. The paper also explained some issues and challenges that MINT encountered in the process of commercialization of its R and D results. (author)

Surface modification of metals by ion implantation

International Nuclear Information System (INIS)

Iwaki, Masaya

1988-01-01

Ion implantation in metals has attracted the attention as a useful technology for the formation of new metastable alloys and compounds in metal surface layers without thermal equilibrium. Current studies of metal surface modification by ion implantation with high fluences have expanded from basic research areas and to industrial applications for the improvement of life time of tools. Many results suggest that the high fluence implantation produces the new surface layers with un-expected microscopic characteristics and macroscopic properties due to implant particles, radiation damage, sputtering, and knock-on doping. In this report, the composition, structure and chemical bonding state in surface layers of iron, iron-based alloy and aluminum sheets implanted with high fluences have been investigated by means of secondary ion mass spectroscopy (SIMS), Auger electron spectroscopy (AES), X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). Tribological properties such as hardness, friction and wear are introduced. (author)

Efficient reanalysis of structures by a direct modification method. [local stiffness modifications of large structures

Science.gov (United States)

Raibstein, A. I.; Kalev, I.; Pipano, A.

1976-01-01

A procedure for the local stiffness modifications of large structures is described. It enables structural modifications without an a priori definition of the changes in the original structure and without loss of efficiency due to multiple loading conditions. The solution procedure, implemented in NASTRAN, involved the decomposed stiffness matrix and the displacement vectors of the original structure. It solves the modified structure exactly, irrespective of the magnitude of the stiffness changes. In order to investigate the efficiency of the present procedure and to test its applicability within a design environment, several real and large structures were solved. The results of the efficiency studies indicate that the break-even point of the procedure varies between 8% and 60% stiffness modifications, depending upon the structure's characteristics and the options employed.

The computational nature of memory modification

Science.gov (United States)

Gershman, Samuel J; Monfils, Marie-H; Norman, Kenneth A; Niv, Yael

2017-01-01

Retrieving a memory can modify its influence on subsequent behavior. We develop a computational theory of memory modification, according to which modification of a memory trace occurs through classical associative learning, but which memory trace is eligible for modification depends on a structure learning mechanism that discovers the units of association by segmenting the stream of experience into statistically distinct clusters (latent causes). New memories are formed when the structure learning mechanism infers that a new latent cause underlies current sensory observations. By the same token, old memories are modified when old and new sensory observations are inferred to have been generated by the same latent cause. We derive this framework from probabilistic principles, and present a computational implementation. Simulations demonstrate that our model can reproduce the major experimental findings from studies of memory modification in the Pavlovian conditioning literature. DOI: http://dx.doi.org/10.7554/eLife.23763.001 PMID:28294944

23 CFR 630.110 - Modification of original agreement.

Science.gov (United States)

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Modification of original agreement. 630.110 Section 630... OPERATIONS PRECONSTRUCTION PROCEDURES Project Authorization and Agreements § 630.110 Modification of original agreement. (a) When changes are needed to the original project agreement, a modification of agreement shall...

Surface modification of ceramics. Ceramics no hyomen kaishitsu

Energy Technology Data Exchange (ETDEWEB)

Hioki, T. (Toyota Central Research and Development Labs., Inc., Nagoya (Japan))

1993-07-05

Surface modification of ceramics and some study results using in implantation in surface modification are introduced. The mechanical properties (strength, fracture toughness, flaw resistance) of ceramics was improved and crack was repaired using surface modification by ion implantation. It is predicted that friction and wear properties are considerably affected because the hardness of ceramics is changed by ion implantation. Cementing and metalization are effective as methods for interface modification and the improvement of the adhesion power of the interface between metal and ceramic is their example. It was revealed that the improvement of mechanical properties of ceramics was achieved if appropriate surface modification was carried out. The market of ceramics mechanical parts is still small, therefore, the present situation is that the field of activities for surface modification of ceramics is also narrow. However, it is thought that in future, ceramics use may be promoted surely in the field like medicine and mechatronics. 8 refs., 4 figs.

The Environmental Assessment and Management (TEAM) Guide: Colorado Supplement

Science.gov (United States)

2010-03-01

Nest c. Flattops d. Great Sand Dunes e. La Garita f. Maroon Bells -- Snowmass g. Mount Zirkel h. Rawah i. Weminuche j. West Elk B. All...of Sections XIII.D., XIII.E., or XIII.F.: 1. National Monuments a. Florissant Fossil Beds b. Colorado c. Dinosaur d. Great Sand Dunes (those...that the minimum distance between tanks and toe of interior dike walls is 5 ft (1.5 m). Verify that drains for diked area are controlled in a manner so

Plasmochemical modification of aluminum-zinc alloys using NH{sub 3}-Ar atmosphere with anti-wear coatings deposition

Energy Technology Data Exchange (ETDEWEB)

Kyzioł, Karol, E-mail: kyziol@agh.edu.pl [Faculty of Materials Science and Ceramics, AGH University of Science and Technology, A. Mickiewicza Av. 30, 30 059 Kraków (Poland); Koper, Katarzyna [Faculty of Materials Science and Ceramics, AGH University of Science and Technology, A. Mickiewicza Av. 30, 30 059 Kraków (Poland); Kaczmarek, Łukasz [Institute of Materials Science and Engineering, Lodz University of Technology, Stefanowskiego Str. 1/15, 90 924 Łódz (Poland); Grzesik, Zbigniew [Faculty of Materials Science and Ceramics, AGH University of Science and Technology, A. Mickiewicza Av. 30, 30 059 Kraków (Poland)

2017-03-01

This paper constitutes a continuation of studies on modification technologies for 7075 series aluminum alloys (Al-Zn) in plasmochemical conditions using the RF CVD (Radio-Frequency Chemical Vapor Deposition) method. This technique is simultaneously the second stage of alloy ageing. The presented results concern optimization of alloy surface modification using N{sup +} ions (in NH{sub 3} or NH{sub 3}/Ar atmosphere) before obtaining a DLC (Diamond-Like Carbon) layer doped with Si and N. From the results it can be concluded that the most profitable mechanical properties (H, ca. 12 GPa and E, ca. 115 GPa) are obtained when the SiCNH coating process is preceded by Al-Zn alloy surface modification with nitrogen ions. These ions are provided by a flowing NH{sub 3} and Ar gas mixture (1:1 ratio). In these process conditions, the lowest tribological wear of the surface is also observed. Furthermore, the obtained coating exhibits a fine-grained structure. - Highlights: • Surface properties of Al-Zn alloy after plasma processes are investigated. • Modification in a RF reactor was the second stage of ageing. • The N{sup +} ion treatments of aluminum substrates was justified. • SiCNH coatings obtained on Al alloys significantly improve mechanical parameters.

Structural dynamic modification

Indian Academy of Sciences (India)

and stiffness matrices) andaor modal parameters, in order to acquire some ... For the above reasons, another modification approach is presented here ... The data necessary to solve the direct problem are dynamic behaviour of the original.

Investigating MCTS Modifications in General Video Game Playing

DEFF Research Database (Denmark)

Frydenberg, Frederik; Andersen, Kasper; Risi, Sebastian

2015-01-01

-style video games. This paper investigates of how well these modifications perform in general video game playing using the general video game AI (GVG-AI) framework and introduces a new MCTS modification called UCT reverse penalty that penalizes the MCTS controller for exploring recently visited children......While Monte Carlo tree search (MCTS) methods have shown promise in a variety of different board games, more complex video games still present significant challenges. Recently, several modifications to the core MCTS algorithm have been proposed with the hope to increase its effectiveness on arcade....... The results of our experiments show that a combination of two MCTS modifications can improve the performance of the vanilla MCTS controller, but the effectiveness of the modifications highly depends on the particular game being played....

Minimal modification to tribimaximal mixing

International Nuclear Information System (INIS)

He Xiaogang; Zee, A.

2011-01-01

We explore some ways of minimally modifying the neutrino mixing matrix from tribimaximal, characterized by introducing at most one mixing angle and a CP violating phase thus extending our earlier work. One minimal modification, motivated to some extent by group theoretic considerations, is a simple case with the elements V α2 of the second column in the mixing matrix equal to 1/√(3). Modifications by keeping one of the columns or one of the rows unchanged from tribimaximal mixing all belong to the class of minimal modification. Some of the cases have interesting experimentally testable consequences. In particular, the T2K and MINOS collaborations have recently reported indications of a nonzero θ 13 . For the cases we consider, the new data sharply constrain the CP violating phase angle δ, with δ close to 0 (in some cases) and π disfavored.

Disassembling and modification of RA-3

International Nuclear Information System (INIS)

Tarizzo, R.D.

1990-01-01

The objective of this paper is to describe the partial disassembling and modification of RA-3, called the Modernization Project. It comprises all the technical and administrative steps directly related with this task. The improvement of RA-3 is a result of the lack of 90% enriched uranium obliging a change over to 20% enriched uranium. This brought about design modifications both in fuel elements and the reactor. The presentation of documents for the licensing authority as well as are detailed separately. The modernization project was divided in 25 tasks: 1) changing fuel element support table, 2) changing heat exchanger, 3) repairing of cooling towers, 4) repairing of primary circuit valves, 5) repairing of irradiation channels, 6) construction of a new sampler, 7) changing tangential channel, 8) cleaning and disassembling of reactor (inside), 9) changing continuous demineralizer (ion exchange column), 10) detection of failure in fuel elements, 11) modification of nuclear instrumentation, 12) modification of conventional instrumentation, 13) modification of electrical system, 14) changing telemanipulators, 15) construction of mechanism bridge, 16) changing a primary circuit valve when the heat exchanger is changed too, 17) painting ground floor, hall floor, and pump room floor with epoxy resin levelling, 18) installation of fire alarm system, 19) radioactive liquid discharge, 20) modification of secondary circuit (This task involves: a) installation of a third secondary pump, b) extension of this piping, c) installation of two 12 inch valves to the present cooling towers pools independent, d) installation of filtering system), 21) optimization hot water bed, 22) changing detector support table, 23) removal, decontamination and reinstallation of shielding, 25) changing pneumatic system

Investigation of the Bitumen Modification Process Regime Parameters Influence on Polymer-Bitumen Bonding Qualitative Indicators

Science.gov (United States)

Belyaev, P. S.; Mishchenko, S. V.; Belyaev, V. P.; Belousov, O. A.; Frolov, V. A.

2018-04-01

The objects of this study are petroleum road bitumen and polymeric bituminous binder for road surfaces obtained by polymer materials. The subject of the study is monitoring the polymer-bitumen binder quality changes as a result of varying the bitumen modification process. The purpose of the work is to identify the patterns of the modification process and build a mathematical model that provides the ability to calculate and select technological equipment. It is shown that the polymer-bitumen binder production with specified quality parameters can be ensured in apparatuses with agitators in turbulent mode without the colloidal mills use. Bitumen mix and modifying additives limiting indicators which can be used as restrictions in the form of mathematical model inequalities are defined. A mathematical model for the polymer-bitumen binder preparation has been developed and its adequacy has been confirmed.

Modification degrees at specific sites on heparan sulphate: an approach to measure chemical modifications on biological molecules with stable isotope labelling

Science.gov (United States)

Wu, Zhengliang L.; Lech, Miroslaw

2005-01-01

Chemical modification of biological molecules is a general mechanism for cellular regulation. A quantitative approach has been developed to measure the extent of modification on HS (heparan sulphates). Sulphation on HS by sulphotransferases leads to variable sulphation levels, which allows cells to tune their affinities to various extracellular proteins, including growth factors. With stable isotope labelling and HPLC-coupled MS, modification degrees at various O-sulphation sites could be determined. A bovine kidney HS sample was first saturated in vitro with 34S by an OST (O-sulphotransferase), then digested with nitrous acid and analysed with HPLC-coupled MS. The 34S-labelled oligosaccharides were identified based on their unique isotope clusters. The modification degrees at the sulphotransferase recognition sites were obtained by calculating the intensities of isotopic peaks in the isotope clusters. The modification degrees at 3-OST-1 and 6-OST-1 sites were examined in detail. This approach can also be used to study other types of chemical modifications on biological molecules. PMID:15743272

Epigenetic Modifications: Therapeutic Potential in Cancer

Directory of Open Access Journals (Sweden)

Manisha Sachan

2015-08-01

Full Text Available Epigenetic modifications and alterations in chromatin structure and function contribute to the cumulative changes observed as normal cells undergo malignant transformation. These modifications and enzymes (DNA methyltransferases, histone deacetylases, histone methyltransferases, and demethylases related to them have been deeply studied to develop new drugs, epigenome-targeted therapies and new diagnostic tools. Epigenetic modifiers aim to restore normal epigenetic modification patterns through the inhibition of epigenetic modifier enzymes. Four of them (azacitidine, decitabine, vorinostat and romidepsin are approved by the U.S. Food and Drug Administration. This article provides an overview about the known functional roles of epigenetic enzymes in cancer development.

14 CFR 21.9 - Replacement and modification articles.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Replacement and modification articles. 21.9... CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS General § 21.9 Replacement and modification articles. (a) If a person knows, or should know, that a replacement or modification article is reasonably likely to be...

Getting Results: Small Changes, Big Cohorts and Technology

Science.gov (United States)

Kenney, Jacqueline L.

2012-01-01

This paper presents an example of constructive alignment in practice. Integrated technology supports were deployed to increase the consistency between learning objectives, activities and assessment and to foster student-centred, higher-order learning processes in the unit. Modifications took place over nine iterations of a second-year Marketing…

Report: Ordine del sentire e apertura al mondo. Filosofia delle emozioni e processo   di individuazione della persona. XIII Convegno internazionale della Max‐Scheler‐Gesellschaft Università di Verona 27‐30 Maggio 2015

Directory of Open Access Journals (Sweden)

Speranza, Maria Teresa

2015-06-01

Full Text Available An interesting debate on the issue of personal identity and its ethical implications has animated the days of the XIII International Congress of Max Scheler‐Gesellschaft. A large program of work has garnered numerous perspectives on the philosophy of person and the phenomenology of otherness, investigating in particular the role of emotions in the formation of person process. The main topic of conference was the Max Scheler’s phenomenology of emotions, which is an important turning point in the philosophy of twentieth century. The formation of ordo amoris, or rather order of feeling, generates the self‐ transcendence of the immediate feeling in virtue, in which the person realizes her singularity. The emotion, therefore, doesn’t remain confined in a state of mind and inner private but acts in the world, creating the emotional breakthrough (emotioneller Durchbruch that makes me exist in a new way in the world, which allows me to act according to my ordo amoris.

Modification of metallic corrosion by ion implantation

International Nuclear Information System (INIS)

Clayton, C.R.

1981-01-01

This review will consider some of the properties of surface alloys, formed by ion implantation, which are effective in modifying corrosion behaviour. Examples will be given of the modification of the corrosion behaviour of pure metals, steels and other engineering alloys, resulting from implantation with metals and metalloids. Emphasis will be given to the modification of anodic processes produced by ion implantation since a review will be given elsewhere in the proceedings concerning the modification of cathodic processes. (orig.)

IEA Bioenergy. Annual report 1997

International Nuclear Information System (INIS)

1997-01-01

The report describes the organization and the results of recently completed and ongoing tasks. Ongoing tasks in 1997 were: Biomass Production, Harvesting and Supply (Task XII); Biomass Utilization (Task XIII); Energy Recovery from Municipal Solid Waste (Task XIV); Greenhouse Gas Balances of Bioenergy Systems (Task XV); and Technology Assessment Studies for the Conversion of Cellulosic Materials to Ethanol in Sweden (Task XVI). Lists of publications from the different tasks are given

IEA Bioenergy. Annual report 1997

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-12-31

The report describes the organization and the results of recently completed and ongoing tasks. Ongoing tasks in 1997 were: Biomass Production, Harvesting and Supply (Task XII); Biomass Utilization (Task XIII); Energy Recovery from Municipal Solid Waste (Task XIV); Greenhouse Gas Balances of Bioenergy Systems (Task XV); and Technology Assessment Studies for the Conversion of Cellulosic Materials to Ethanol in Sweden (Task XVI). Lists of publications from the different tasks are given

IEA Bioenergy. Annual report 1997

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-12-31

The report describes the organization and the results of recently completed and ongoing tasks. Ongoing tasks in 1997 were: Biomass Production, Harvesting and Supply (Task XII); Biomass Utilization (Task XIII); Energy Recovery from Municipal Solid Waste (Task XIV); Greenhouse Gas Balances of Bioenergy Systems (Task XV); and Technology Assessment Studies for the Conversion of Cellulosic Materials to Ethanol in Sweden (Task XVI). Lists of publications from the different tasks are given

Analysis of Modifications on a Spark Ignition Engine for Operation with Natural Gas

Directory of Open Access Journals (Sweden)

Ramasamy D.

2016-01-01

Full Text Available Transportation is one of the key contributors to petroleum usage and emissions to the atmosphere. According to researchers, there are many ways to use transport by using renewable energy sources. Of these solutions, the immediate solution which requires less modification to current engine technology is by using gaseous fuels. Natural gas is the fuel of choice for minor modification to current engines. As it can be derived from anaerobic digestion process, the potential as a renewable energy source is tremendous, especially for an agricultural country such a Malaysia. The aim in the future will be operating an engine with natural gas only with pipelines straight to houses for easy filling. The fuel is light and can be easily carried in vehicles when in compressed form. As such, Compressed Natural Gas (CNG is currently used in bi-fuel engines, but is mostly not optimized in term of their performance. The focus of the paper is to optimize a model of natural gas engine by one dimensional flow modeling for operation with natural gas. The model is analyzed for performance and emission characteristics produced by a gasoline engine and later compared with natural gas. The average performance drop is about 15% from its gasoline counterpart. The 4% benchmark indicates that the modification to ignition timing and compression ratio does improve engine performance using natural gas as fuel.

Development of thermal conditioning technology for Alpha-containment wastes: Alpha-contaminated waste incineration technology

Energy Technology Data Exchange (ETDEWEB)

Kim, Joon Hyung; Kim, Jeong Guk; Yang, Hee Chul; Choi, Byung Seon; Jeong, Myeong Soo

1999-03-01

As the first step of a 3-year project named 'development of alpha-contaminated waste incineration technology', the basic information and data were reviewed, while focusing on establishment of R and D direction to develop the final goal, self-supporting treatment of {alpha}- wastes that would be generated from domestic nuclear industries. The status on {alpha} waste incineration technology of advanced states was reviewed. A conceptual design for {alpha} waste incineration process was suggested. Besides, removal characteristics of volatile metals and radionuclides in a low-temperature dry off-gas system were investigated. Radiation dose assessments and some modification for the Demonstration-scale Incineration Plant (DSIP) at Korea Atomic Energy Research Institute (KAERI) were also done.

Development of thermal conditioning technology for Alpha-containment wastes: Alpha-contaminated waste incineration technology

International Nuclear Information System (INIS)

Kim, Joon Hyung; Kim, Jeong Guk; Yang, Hee Chul; Choi, Byung Seon; Jeong, Myeong Soo

1999-03-01

As the first step of a 3-year project named 'development of alpha-contaminated waste incineration technology', the basic information and data were reviewed, while focusing on establishment of R and D direction to develop the final goal, self-supporting treatment of α- wastes that would be generated from domestic nuclear industries. The status on α waste incineration technology of advanced states was reviewed. A conceptual design for α waste incineration process was suggested. Besides, removal characteristics of volatile metals and radionuclides in a low-temperature dry off-gas system were investigated. Radiation dose assessments and some modification for the Demonstration-scale Incineration Plant (DSIP) at Korea Atomic Energy Research Institute (KAERI) were also done

TWO MODIFICATIONS OF SCALERS FOR RATE STUDIES

Energy Technology Data Exchange (ETDEWEB)

Hodgson, T. S.; Gordon, B. E.

1964-04-15

Two simple modifications to nuclear scalers have been developed. The first involves an automatic stepping switch which permits a single scaler to be actuated by up to four Geiger counters in sequence and to record the time to reach a preset count for each. The second modification is designed to pick a pulse off a conventional scaler when a preset count has been reached and to use the pulse to actuate a recorder. Both modifications considerably extend the utility of conventional scalers.

Modifications of the Weibull distribution: A review

International Nuclear Information System (INIS)

Almalki, Saad J.; Nadarajah, Saralees

2014-01-01

It is well known that the Weibull distribution is the most popular and the most widely used distribution in reliability and in analysis of lifetime data. Unfortunately, its hazard function cannot exhibit non-monotonic shapes like the bathtub shape or the unimodal shape. Since 1958, the Weibull distribution has been modified by many researchers to allow for non-monotonic hazard functions. This paper gives an extensive review of some discrete and continuous versions of the modifications of the Weibull distribution. - Highlights: • A comprehensive review of known discrete modifications and generalizations of the Weibull distribution. • A comprehensive review of known continuous modifications and generalizations of the Weibull distribution. • Over 110 references on modifications/generalizations of the Weibull distribution. • More than 55% of the cited references appeared in the last 5 years

As parroquias do Porriño, Cans e Atios na documentación do mosteiro cisterciense de Santa María de Melón. Séculos XII e XIII

Directory of Open Access Journals (Sweden)

Gradín Fernández, Isis

2011-12-01

Full Text Available After the introduction and criteria of transcription, 31 papers are published from the twelfth and thirteenth centuries belonging to the Cistercian monastery of Santa Maria de Melon, specifically those that permit the reconstruction of old possessions, focusing on the current council of O Porriño -which was the monastery of San Miguel de Cans, absorbed by the cistercian monks of Melon. A paleographic and historical approximation of this documentation is done, which is complemented with the corresponding index of names and place names.

[gl] Trala introducción e criterios de transcripción, edítanse 31 documentos dos séculos XII e XIII pertencentes ó mosteiro cisterciense de Santa María de Melón, concretamente aqueles que permiten reconstruír as antigas posesións –centradas sobre o actual concello de O Porriño- do que foi o mosteiro de San Miguel de Cans, absorvido polos monxes cistercienses de Melón. Faise unha aproximación paleográfica e histórica da documentación, que se complementa cos correspondentes índices onomásticos e toponímicos.

Biopolymer system for permeability modification in porous media

Energy Technology Data Exchange (ETDEWEB)

Stepp, A.K.; Bryant, R.S.; Llave, F.M. [BMD-Oklahoma, Inc., Bartlesville, OK (United States)] [and others

1995-12-31

New technologies are needed to reduce the current high rate of well abandonment. Improved sweep efficiency, reservoir conformance, and permeability modification can have a significant impact on oil recovery processes. Microorganisms can be used to selectively plug high-permeability zones to improve sweep efficiency and impart conformance control. Studies of a promising microbial system for polymer production were conducted to evaluate reservoir conditions in which this system would be effective. Factors which can affect microbial growth and polymer production include salinity, pH, temperature, divalent ions, presence of residual oil, and rock matrix. Flask tests and coreflooding experiments were conducted to optimize and evaluate the effectiveness of this system. Nuclear magnetic resonance imaging (NMRI) was used to visualize microbial polymer production in porous media. Changes in fluid distribution within the pore system of the core were detected.

Three Sisters Dam modifications and performance

Energy Technology Data Exchange (ETDEWEB)

Courage, L.J.R. [Monenco AGRA Inc., Calgary, AB (Canada)

1995-12-31

Recent modifications and maintenance carried out at the Three Sisters Dam, in the Alberta Rockies south of the town of Canmore, were described. A detailed account was given of the dam`s geological setting, its abnormally high leakage through the foundation and its sinkhole activity. Results of studies aimed at finding the cause of leakage and sinkhole occurrences were reviewed. Modifications made to the dam since 1951 were detailed, as were modifications to handle probable maximum flood levels. Three approaches for estimating failure probabilities after identification of failure modes were described. The overall conclusion was that based on constant leakage, no settlement in the dam, penstocks, or the powerhouse since construction, the Three Sisters Dam was stable. 1 ref.

An Empirical Analysis of United States Consumers' Concerns about Eight Food Production and Processing Technologies

OpenAIRE

Hwang, Yun Jae; Roe, Brian E.; Teisl, Mario F.

2005-01-01

For a representative sample of U.S. consumers, we rank, correlate and explain ratings of concern toward eight food production and processing technologies (antibiotics, pesticides, artificial growth hormones, genetic modification, irradiation, artificial colors/flavors, pasteurization, and preservatives). Concern is highest for pesticides and hormones, followed by concern toward antibiotics, genetic modification and irradiation. We document standard relationships between many demographic, econ...

Microscopic mechanism of amino silicone oil modification and modification effect with different amino group contents based on molecular dynamics simulation

Science.gov (United States)

He, Liping; Li, Wenjun; Chen, Dachuan; Yuan, Jianmin; Lu, Gang; Zhou, Dianwu

2018-05-01

The microscopic mechanism of amino silicone oil (ASO) modification of natural fiber was investigated for the first time using molecular dynamics (MD) simulation at the atomic and molecular levels. The MD simulation results indicated that the ASO molecular interacted with the cellulose molecular within the natural fiber, mainly by intermolecular forces of Nsbnd Hsbnd O and Osbnd Hsbnd N hydrogen bonds and the molecular chain of ASO absorbed onto the natural fiber in a selective orientation, i.e., the hydrophobic alkyl groups (sbnd CnH2n+1) project outward and the polar amino groups (sbnd NH2) point to the surface of natural fiber. Consequently, the ASO modification changed the surface characteristic of natural fiber from hydrophilic to hydrophobic. Furthermore, the modification effects of the ASO modification layer with different amino group contents (m:n ratio) were also evaluated in this study by calculating the binding energy between the ASO modifier and natural fiber, and the cohesive energy density and free volume of the ASO modification layer. The results showed that the binding energy reached a maximum when the m:n ratio of ASO was of 8:4, suggesting that a good bonding strength was achieved at this m:n ratio. It was also found that the cohesive energy density enhanced with the increase in the amino group content, and the higher the cohesive energy density, the easier the formation of the ASO modification layer. However, the fraction free volume decreased with the increase in the amino group content. This is good for improving the water-proof property of natural fiber. The present work can provide an effective method for predicting the modification effects and designing the optimized m:n ratio of ASO modification.

Mixed Waste Integrated Program emerging technology development

International Nuclear Information System (INIS)

Berry, J.B.; Hart, P.W.

1994-01-01

The US Department of Energy (DOE) is responsible for the management and treatment of its mixed low-level wastes (MLLW). MLLW are regulated under both the Resource Conservation and Recovery Act and various DOE orders. Over the next 5 years, DOE will manage over 1.2 m 3 of MLLW and mixed transuranic (MTRU) wastes. In order to successfully manage and treat these mixed wastes, DOE must adapt and develop characterization, treatment, and disposal technologies which will meet performance criteria, regulatory approvals, and public acceptance. Although technology to treat MLLW is not currently available without modification, DOE is committed to developing such treatment technologies and demonstrating them at the field scale by FY 1997. The Office of Research and Development's Mixed Waste Integrated Program (MWIP) within the DOE Office of Environmental Management (EM), OfFice of Technology Development, is responsible for the development and demonstration of such technologies for MLLW and MTRU wastes. MWIP advocates and sponsors expedited technology development and demonstrations for the treatment of MLLW

Posttranslational Modification Biology of Glutamate Receptors and Drug Addiction

Directory of Open Access Journals (Sweden)

Li-Min eMao

2011-03-01

Full Text Available Posttranslational covalent modifications of glutamate receptors remain a hot topic. Early studies have established that this family of receptors, including almost all ionotropic and metabotropic glutamate receptor subtypes, undergoes active phosphorylation at serine, threonine, or tyrosine residues on their intracellular domains. Recent evidence identifies several glutamate receptor subtypes to be direct substrates for palmitoylation at cysteine residues. Other modifications such as ubiquitination and sumoylation at lysine residues also occur to certain glutamate receptors. These modifications are dynamic and reversible in nature and are regulatable by changing synaptic inputs. The regulated modifications significantly impact the receptor in many ways, including interrelated changes in biochemistry (synthesis, subunit assembling and protein-protein interactions, subcellular redistribution (trafficking, endocytosis, synaptic delivery and clustering, and physiology, usually associated with changes in synaptic plasticity. Glutamate receptors are enriched in the striatum and cooperate closely with dopamine to regulate striatal signaling. Emerging evidence shows that modification processes of striatal glutamate receptors are sensitive to addictive drugs, such as psychostimulants (cocaine and amphetamines. Altered modifications are believed to be directly linked to enduring receptor/synaptic plasticity and drug-seeking. This review summarizes several major types of modifications of glutamate receptors and analyzes the role of these modifications in striatal signaling and in the pathogenesis of psychostimulant addiction.

On the genetic modification of psychology, personality, and behavior.

Science.gov (United States)

Neitzke, Alex B

2012-12-01

I argue that the use of heritable modifications for psychology, personality, and behavior should be limited to the reversal or prevention of relatively unambiguous instances of pathology or likely harm (e.g. sociopathy). Most of the likely modifications of psychological personality would not be of this nature, however, and parents therefore should not have the freedom to make such modifications to future children. I argue by examining the viewpoints of both the individual and society. For individuals, modifications would interfere with their capacity for self-determination in a way that undermines the very concept of self-determination. I argue that modification of psychology and personality is unlike present parenting in morally significant ways. For society, modification offers a medium for power to manipulate the makeup of persons and populations, possibly causing biological harm to the species and altering our conceptions of social responsibility.

Pretreatment and Membrane Hydrophilic Modification to Reduce Membrane Fouling

Directory of Open Access Journals (Sweden)

Huaqiang Chu

2013-09-01

Full Text Available The application of low pressure membranes (microfiltration/ultrafiltration has undergone accelerated development for drinking water production. However, the major obstacle encountered in its popularization is membrane fouling caused by natural organic matter (NOM. This paper firstly summarizes the two factors causing the organic membrane fouling, including molecular weight (MW and hydrophilicity/hydrophobicity of NOM, and then presents a brief introduction of the methods which can prevent membrane fouling such as pretreatment of the feed water (e.g., coagulation, adsorption, and pre-oxidation and membrane hydrophilic modification (e.g., plasma modification, irradiation grafting modification, surface coating modification, blend modification, etc.. Perspectives of further research are also discussed.

Examining the Teaching of Science, and Technology and Engineering Content and Practices: An Instrument Modification Study

Science.gov (United States)

Love, Tyler S.; Wells, John G.; Parkes, Kelly A.

2017-01-01

A modified Reformed Teaching Observation Protocol (RTOP) (Piburn & Sawada, 2000) instrument was used to separately examine eight technology and engineering (T&E) educators' teaching of science, and T&E content and practices, as called for by the "Standards for Technological Literacy: Content for the Study of Technology"…

Technology Applications for Children with ADHD: Assessing the Empirical Support.

Science.gov (United States)

Xu, Chunzhen; Reid, Robert; Steckelberg, Allen

2002-01-01

This article reviews technology research (n=20) with students with attention deficit hyperactivity disorder (ADHD) in five categories: computer-assisted instruction, computer-based cognitive training, biofeedback training, assessment, and behavior modification. Analysis of available research suggests there is little well controlled experimental…

Modification of JRR-4 based on safety evaluation

Energy Technology Data Exchange (ETDEWEB)

Izumo, Hironobu; Nakajima, Teruo; Funayama, Yoshiro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

1998-10-01

Since the first criticality was achieved on January 28, 1965, JRR-4 has been operated safely until on January 12, 1996. The modification of JRR-4 was planned according to the framework of reduced enrichment on research reactor program. The modification was designed based on the several national safety guides. JRR-4 has some modifications of facilities to satisfy the guides and guides criteria. (author)

The impact of genetic modification of human foods in the 21st century: a review.

Science.gov (United States)

Uzogara, S G

2000-05-01

Genetic engineering of food is the science which involves deliberate modification of the genetic material of plants or animals. It is an old agricultural practice carried on by farmers since early historical times, but recently it has been improved by technology. Many foods consumed today are either genetically modified (GM) whole foods, or contain ingredients derived from gene modification technology. Billions of dollars in U.S. food exports are realized from sales of GM seeds and crops. Despite the potential benefits of genetic engineering of foods, the technology is surrounded by controversy. Critics of GM technology include consumer and health groups, grain importers from European Union (EU) countries, organic farmers, environmentalists, concerned scientists, ethicists, religious rights groups, food advocacy groups, some politicians and trade protectionists. Some of the specific fears expressed by opponents of GM technology include alteration in nutritional quality of foods, potential toxicity, possible antibiotic resistance from GM crops, potential allergenicity and carcinogenicity from consuming GM foods. In addition, some more general concerns include environmental pollution, unintentional gene transfer to wild plants, possible creation of new viruses and toxins, limited access to seeds due to patenting of GM food plants, threat to crop genetic diversity, religious, cultural and ethical concerns, as well as fear of the unknown. Supporters of GM technology include private industries, research scientists, some consumers, U.S. farmers and regulatory agencies. Benefits presented by proponents of GM technology include improvement in fruit and vegetable shelf-life and organoleptic quality, improved nutritional quality and health benefits in foods, improved protein and carbohydrate content of foods, improved fat quality, improved quality and quantity of meat, milk and livestock. Other potential benefits are: the use of GM livestock to grow organs for transplant

Mapping Base Modifications in DNA by Transverse-Current Sequencing

Science.gov (United States)

Alvarez, Jose R.; Skachkov, Dmitry; Massey, Steven E.; Kalitsov, Alan; Velev, Julian P.

2018-02-01

Sequencing DNA modifications and lesions, such as methylation of cytosine and oxidation of guanine, is even more important and challenging than sequencing the genome itself. The traditional methods for detecting DNA modifications are either insensitive to these modifications or require additional processing steps to identify a particular type of modification. Transverse-current sequencing in nanopores can potentially identify the canonical bases and base modifications in the same run. In this work, we demonstrate that the most common DNA epigenetic modifications and lesions can be detected with any predefined accuracy based on their tunneling current signature. Our results are based on simulations of the nanopore tunneling current through DNA molecules, calculated using nonequilibrium electron-transport methodology within an effective multiorbital model derived from first-principles calculations, followed by a base-calling algorithm accounting for neighbor current-current correlations. This methodology can be integrated with existing experimental techniques to improve base-calling fidelity.

Application of radiation chemistry in materials modification and environmental protection

International Nuclear Information System (INIS)

Chmielewski, A.G.

2007-01-01

thermoshrinkable tubes and types possessing '' memory effect ''. Through radiation, grafting metal adsorbents and ion exchange membranes can be developed. Radiation is early applied tool in the area of nanomaterials engineering; arrangement of atoms and ions has been performed using ion or electron beams for many years. New trends concern surface curing and development of ion track membranes and controlled release drug-delivery systems. Finally, radiation processing concerns gem stones colorization, development of high temperature resistant fibers (SiC) and semiconductor modification. Over the past few years, radiation processing technologies aimed at ensuring the safety of gaseous and liquid effluents discharged to the environment have been developed. It has been demonstrated that radiation processing based technologies for flue gas treatment (SO X and NO X removal), wastewater purification, and sludge hygienization can be effectively deployed to mitigate environmental degradation. Electron beam technology is among the most promising advanced technologies of new generation. This is a dry-scrubbing process of simultaneous SO 2 and NO x removal, where no waste except the fertilizer by-product are generated.The other possibility is application of the process for VOC removal. Tests at the pilot plant constructed at a coal-fired power station were performed with the purpose of estimating the influence of electron beam on VOCs present in flue gas, during SO 2 and NO x removal. The removal efficiencies have been ranged from 40% up to 98%. The chlorocarbons including dioxins may be removed with high efficiency as well [57, 58]. During the radiolysis of water reactive radicals of strong oxidizing or reducing properties are formed that can transform the pollutants in the liquids wastes. A large number of substances such as hard surfactants, lignin, pesticides cannot be degraded by conventional biochemical methods and thus escape from decomposition in biological treatment. Research and

Recent findings and technological advances in phosphoproteomics for cells and tissues.

Science.gov (United States)

von Stechow, Louise; Francavilla, Chiara; Olsen, Jesper V

2015-01-01

Site-specific phosphorylation is a fast and reversible covalent post-translational modification that is tightly regulated in cells. The cellular machinery of enzymes that write, erase and read these modifications (kinases, phosphatases and phospho-binding proteins) is frequently deregulated in different diseases, including cancer. Large-scale studies of phosphoproteins - termed phosphoproteomics - strongly rely on the use of high-performance mass spectrometric instrumentation. This powerful technology has been applied to study a great number of phosphorylation-based phenotypes. Nevertheless, many technical and biological challenges have to be overcome to identify biologically relevant phosphorylation sites in cells and tissues. This review describes different technological strategies to identify and quantify phosphorylation sites with high accuracy, without significant loss of analysis speed and reproducibility in tissues and cells. Moreover, computational tools for analysis, integration and biological interpretation of phosphorylation events are discussed.

Repair-modification of radiodamaged genes

International Nuclear Information System (INIS)

Volpe, P.; Institute of Experimental Medicine, Rome; Eremenko, T.

1995-01-01

It is proposed that through repair-modification, the modified base 5mC may have facilitated the divergent evolution of coding (hypomethylated exon) and uncoding (hypermethylated promoter and intron) sequences in eukaryotic genes. The radioinduced repair patches appearing in regions lacking 5mC are fully reconstructed by excision-repair, whereas those appearing in regions containing 5mC are incompletely reconstructed by this conventional mechanism. Such a second class of repair patches may, however, become fully reconstructed, in the S phase, by repair-modification. In fact, while DNA polymerase β - which is a key enzyme of excision-repair - is active through the whole interphase. DNA methylase - which is responsible for post-synthetic DNA modification - is essentially active in S. Uncoupling of these two enzyme systems, outside S, might explain why in unsynchronised cells repair patches of non-replicating strands are hypomethylated when compared with specific methylation of replicating strands. In other words, excision-repair would always be able to re-establish the primary ATGC language of both damaged unmethylated and methylated regions, while repair-modification would be able to re-establish the modified ATGC(5mC) language of the damaged methylated regions, only in S, but not in G 1 or G 2 . In these two phases, when DNA methylation is inversely correlated with pre-mRNA transcription (as in the case of many tissue-specific genes), such demethylation might induce a silent transcriptional unit to become active. (Author)

DNA modification by alkylating compounds

Energy Technology Data Exchange (ETDEWEB)

Kruglyakova, E.E.

1985-09-01

Results are given for research on the physico-chemical properties of alkylating compounds - nitroso alkyl ureas (NAU) which possess a broad spectrum of biological activity, such as mutagenic, carcinogenic, and anti-tumor action that is due to the alkylation and carbamoylation of DNA as well as other cellular components. Identified chemical products of NAU interaction with DNA and its components are cited. Structural conversions of a DNA macromolecule resulting from its chemical modification are examined. NAU are used to discuss possible biological consequences of DNA modification. 148 references.

Corrosion principles and surface modification

International Nuclear Information System (INIS)

Kruger, J.

1982-01-01

This chapter examines the important strategies provided by the newer ideas of corrosion science and engineering that surface modification techniques must utilize to help prevent corrosion, especially the most damaging kind of aqueous corrosion, localized corrosion. Provides a brief introduction to the principles underlying the phenomenon of corrosion in order to use them to discuss surface modification strategies to combat corrosion. Discusses the electrochemistry of corrosion; the thermodynamics of corrosion; the kinetics of corrosion; thermodynamic strategies; and kinetic strategies (formation of more protective passive films; resistance to breakdown; ductility; repassivation)

Surface modifications of magnesium alloys for biomedical applications.

Science.gov (United States)

Yang, Jingxin; Cui, Fuzhai; Lee, In Seop

2011-07-01

In recent years, research on magnesium (Mg) alloys had increased significantly for hard tissue replacement and stent application due to their outstanding advantages. Firstly, Mg alloys have mechanical properties similar to bone which avoid stress shielding. Secondly, they are biocompatible essential to the human metabolism as a factor for many enzymes. In addition, main degradation product Mg is an essential trace element for human enzymes. The most important reason is they are perfectly biodegradable in the body fluid. However, extremely high degradation rate, resulting in too rapid loss of mechanical strength in chloride containing environments limits their applications. Engineered artificial biomaterials with appropriate mechanical properties, surface chemistry, and surface topography are in a great demand. As the interaction between the cells and tissues with biomaterials at the tissue--implant interface is a surface phenomenon; surface properties play a major role in determining both the biological response to implants and the material response to the physiological condition. Therefore, the ability to modify the surface properties while preserve the bulk properties is important, and surface modification to form a hard, biocompatible and corrosion resistant modified layer have always been an interesting topic in biomaterials field. In this article, attempts are made to give an overview of the current research and development status of surface modification technologies of Mg alloys for biomedical materials research. Further, the advantages/disadvantages of the different methods and with regard to the most promising method for Mg alloys are discussed. Finally, the scientific challenges are proposed based on own research and the work of other scientists.

Chemical and physical modification of hemp fibres by steam explosion technology

International Nuclear Information System (INIS)

Sutka, Anna; Kukle, Silvija; Gravitis, Janis; Berzins, Agris

2013-01-01

In current research attempt has been made to analyse hemp fibres treated with steam explosion (SE) technology. Disintegration of hemp fibres separated from non-retted, dew-retted and dried stems of hemp ('Purini')[1] by alkali treatment and steam explosion (SE) were investigated. An average intensive SE in combination with the hydro-thermal and alkali after-treatment allows decreasing the diameter of hemp fibres and reduce the concentration of non-celluloses components, among them hemicelluloses, lignin, pectin, waxes and water [1;2

MODIFICATION OF SURFACE KONDENSITSIONNYH AEROSOLS WELDING AND METALLURGICHESKIH PRODUCTIONS

Directory of Open Access Journals (Sweden)

A. A. Ennan

2016-04-01

Full Text Available Chemical modification of surface kondensitsionnyh aerosols (KA which formation when heat treatment metals (process of weld, foundry processes with application chlorosilanes are suggested. Adsorbtion vapor of water on modification powders KA decreases and changes in varies from modifier and conditions modification are setted.

12 CFR 725.21 - Modification of agreements.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Modification of agreements. 725.21 Section 725.21 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.21 Modification of agreements. The...

Surface Modification of Biomaterials: A Quest for Blood Compatibility

Directory of Open Access Journals (Sweden)

Achala de Mel

2012-01-01

Full Text Available Cardiovascular implants must resist thrombosis and intimal hyperplasia to maintain patency. These implants when in contact with blood face a challenge to oppose the natural coagulation process that becomes activated. Surface protein adsorption and their relevant 3D confirmation greatly determine the degree of blood compatibility. A great deal of research efforts are attributed towards realising such a surface, which comprise of a range of methods on surface modification. Surface modification methods can be broadly categorized as physicochemical modifications and biological modifications. These modifications aim to modulate platelet responses directly through modulation of thrombogenic proteins or by inducing antithrombogenic biomolecules that can be biofunctionalised onto surfaces or through inducing an active endothelium. Nanotechnology is recognising a great role in such surface modification of cardiovascular implants through biofunctionalisation of polymers and peptides in nanocomposites and through nanofabrication of polymers which will pave the way for finding a closer blood match through haemostasis when developing cardiovascular implants with a greater degree of patency.

Feasibility Study for a Structurally Efficient, Multi-Modal Shelter Concept Utilizing Advanced Technology Production Techniques

Science.gov (United States)

1974-02-01

II I~ x p:1 ns ion P roc cuurc Longitudin:-11 Section, Container Mod·c Configuration r Ex p :m s i on Pro c c d u r e Longitudinal Section...No . I II. I I I. IV. v. VI. VII. VIII. IX. X . XI. XII. XIII. XIV. XV . XVI. XVII . XVIII . XIX. XX. XXI. XXII . XXI II. XXIV...mat e rial s and examples from these categories . Glass Fibers Glass Mi c r os pheres As bestos Carbon Graphite Ce llulose Cotton Jute Rayo n

Trophic interaction modifications: an empirical and theoretical framework.

Science.gov (United States)

Terry, J Christopher D; Morris, Rebecca J; Bonsall, Michael B

2017-10-01

Consumer-resource interactions are often influenced by other species in the community. At present these 'trophic interaction modifications' are rarely included in ecological models despite demonstrations that they can drive system dynamics. Here, we advocate and extend an approach that has the potential to unite and represent this key group of non-trophic interactions by emphasising the change to trophic interactions induced by modifying species. We highlight the opportunities this approach brings in comparison to frameworks that coerce trophic interaction modifications into pairwise relationships. To establish common frames of reference and explore the value of the approach, we set out a range of metrics for the 'strength' of an interaction modification which incorporate increasing levels of contextual information about the system. Through demonstrations in three-species model systems, we establish that these metrics capture complimentary aspects of interaction modifications. We show how the approach can be used in a range of empirical contexts; we identify as specific gaps in current understanding experiments with multiple levels of modifier species and the distributions of modifications in networks. The trophic interaction modification approach we propose can motivate and unite empirical and theoretical studies of system dynamics, providing a route to confront ecological complexity. © 2017 The Authors. Ecology Letters published by CNRS and John Wiley & Sons Ltd.

Methods for genetic modification of megakaryocytes and platelets.

Science.gov (United States)

Pendaries, Caroline; Watson, Stephen P; Spalton, Jennifer C

2007-09-01

During recent decades there have been major advances in the fields of thrombosis and haemostasis, in part through development of powerful molecular and genetic technologies. Nevertheless, genetic modification of megakaryocytes and generation of mutant platelets in vitro remains a highly specialized area of research. Developments are hampered by the low frequency of megakaryocytes and their progenitors, a poor efficiency of transfection and a lack of understanding with regard to the mechanism by which megakaryocytes release platelets. Current methods used in the generation of genetically modified megakaryocytes and platelets include mutant mouse models, cell line studies and use of viruses to transform primary megakaryocytes or haematopoietic precursor cells. This review summarizes the advantages, limitations and technical challenges of such methods, with a particular focus on recent successes and advances in this rapidly progressing field including the potential for use in gene therapy for treatment of patients with platelet disorders.

Erratum to 'Surface Modification of PBO Fibers for Composites by Coaxial Atmospheric Dielectric Barrier Discharge (PLA-PLA)'

International Nuclear Information System (INIS)

2013-01-01

There is a mistake in the funding number (National Natural Science Foundation of China (No. 10875146)) of article Surface Modification of PBO Fibers for Composites by Coaxial Atmospheric Dielectric Barrier Discharge (PLA-PLA), written by HU Qianqian, XU Jinzhou, ZHOU Zhenxing, ZHANG Jing, published in Plasma Science and Technology, 2013, Vol. 15, Issue 5, page number 429, it should be corrected as National Natural Science Foundation of China (No. 11075033). (erratum)

Drug delivery from hydrophobic-modified mesoporous silicas: Control via modification level and site-selective modification

International Nuclear Information System (INIS)

Tang Qunli; Chen Yuxi; Chen Jianghua; Li Jin; Xu Yao; Wu Dong; Sun Yuhan

2010-01-01

Dimethylsilyl (DMS) modified mesoporous silicas were successfully prepared via co-condensation and post-grafting modification methods. The post-grafting modification was carried out by the reaction of the as-synthesized MCM-41 material (before CTAB removal) with diethoxydimethylsinale (DEDMS). N 2 adsorption-desorption and 29 Si MAS NMR characterization demonstrated that different amount of DMS groups were successfully incorporated into the co-condensation modified samples, and the functional DMS groups were placed selectively on the pore openings and external pore surfaces in the post-grafting modified samples. Subsequently, the controlled drug delivery properties from the resulting DMS-modified mesoporous silicas were investigated in detail. The drug adsorption experiments showed that the adsorption capacities were mainly depended on the content of silanol group (CSG) in the corresponding carriers. The in vitro tests exhibited that the incorporation of DMS groups greatly retarded the ibuprofen release rate. Moreover, the ibuprofen release profiles could be well modulated by varying DMS modification levels and site-selective distribution of functional groups in mesoporous carriers. - The distribution of DMS groups on the pore surfaces of the mesostructures strongly affects the drug release rate. The P-M41-1 and the P-M41-2 possess the close DMS modification levels as the C-M41-10, but the ibuprofen release rates from the P-M41-1 and P-M41-2 are much slower than that from the C-M41-10.

Surface modifications of dental implants.

Science.gov (United States)

Stanford, C M

2008-06-01

Dental implant surface technologies have been evolving rapidly to enhance a more rapid bone formation on their surface and hold a potential to increase the predictability of expedited implant therapy. While implant outcomes have become highly predictable, there are sites and conditions that result in elevated implant loss. This paper reviews the impact of macro-retentive features which includes approaches to surface oxide modification, thread design, press-fit and sintered-bead technologies to increase predictability of outcomes. Implant designs that lead to controlled lateral compression of the bone can improve primary stability as long as the stress does not exceed the localized yield strength of the cortical bone. Some implant designs have reduced crestal bone loss by use of multiple cutting threads that are closely spaced, smoothed on the tip but designed to create a hoop-stress stability of the implant as it is completely seated in the osteotomy. Following the placement of the implant, there is a predictable sequence of bone turnover and replacement at the interface that allows the newly formed bone to adapt to microscopic roughness on the implant surface, and on some surfaces, a nanotopography (<10(-9) m scale) that has been shown to preferably influence the formation of bone. Newly emerging studies show that bone cells are exquisitely sensitive to these topographical features and will upregulate the expression of bone related genes for new bone formation when grown on these surfaces. We live in an exciting time of rapid changes in the modalities we can offer patients for tooth replacement therapy. Given this, it is our responsibility to be critical when claims are made, incorporate into our practice what is proven and worthwhile, and to continue to support and provide the best patient care possible.

Eco-friendly surface modification on polyester fabrics by esterase treatment

Energy Technology Data Exchange (ETDEWEB)

Wu, Jindan; Cai, Guoqiang; Liu, Jinqiang; Ge, Huayun; Wang, Jiping, E-mail: jipingwanghz@gmail.com

2014-03-01

Graphical abstract: - Highlights: • We used a simple and easy way to measure the enzyme activity. • We studied the mechanism by characterizing the chemical changes in the surface of fabric. • We studied the advantages in surface wettability, fiber integrity and mechanical performance of cutinase treated fabrics. • Cutinase pretreated fibers exhibited much improved fabric wicking and better fiber integrity comparing to alkali treated ones. • Cutinase pretreatment technology promotes energy conservation and emission reduction. - Abstract: Currently, traditional alkali deweighting technology is widely used to improve the hydrophilicity of polyester fabrics. However, the wastewater and heavy chemicals in the effluent cause enormous damage to the environment. Esterase treatment, which is feasible in mild conditions with high selectivity, can provide a clean and efficient way for polyester modification. Under the optimum conditions, the polyester fabric hydrolysis process of esterase had a linear kinetics. X-ray photoelectron spectrometry (XPS) results showed that hydroxyl and carboxyl groups were produced only on the surface of modified fiber without changing the chemical composition of the bulk. These fibers exhibited much improved fabric wicking, as well as greatly improved oily stain removal performance. Compared to the harsh alkali hydrolysis, the enzyme treatment led to smaller weight loss and better fiber integrity. The esterase treatment technology is promising to produce higher-quality polyester textiles with an environmental friendly approach.

Medium Modifications of Hadrons in Photon Induced Reactions

International Nuclear Information System (INIS)

Schadmand, S.

2004-01-01

Indications for in-medium modifications of hadron properties are reported from photoabsorption and meson production experiments. Strong medium modifications are observed in inclusive photoabsorption experiments and theoretical models investigate the in-medium dynamics of baryon resonances and their coupling to mesons. Recent experiments study the in-medium behavior of scalar and vector mesons where theoretical models expect in-medium modifications of the meson spectral functions that might be connected to partial restoration of chiral symmetry

Protein covalent modification by biologically active quinones

Directory of Open Access Journals (Sweden)

MIROSLAV J. GASIC

2004-11-01

Full Text Available The avarone/avarol quinone/hydroquinone couple shows considerable antitumor activity. In this work, covalent modification of b-lactoglobulin by avarone and its derivatives as well as by the synthetic steroidal quinone 2,5(10-estradiene-1,4,17-trione and its derivatives were studied. The techniques for studying chemical modification of b-lactoglobulin by quinones were: UV/Vis spectrophotometry, SDS PAGE and isoelectrofocusing. SDS PAGE results suggest that polymerization of the protein occurs. It could be seen that the protein of 18 kD gives the bands of 20 kD, 36 kD, 40 kD, 45 kD, 64 kD and 128 kD depending on modification agent. The shift of the pI of the protein (5.4 upon modification toward lower values (from pI 5.0 to 5.3 indicated that lysine amino groups are the principal site of the reaction of b-lactoglobulin with the quinones.

Advanced Reactor Technologies - Regulatory Technology Development Plan (RTDP)

Energy Technology Data Exchange (ETDEWEB)

Moe, Wayne L. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2017-08-23

importance of key DOE reactor research initiatives should be assessed early in the technology development process. Quality assurance requirements supportive of later licensing activities must also be attached to important research activities to ensure resulting data is usable in that context. Early regulatory analysis and licensing approach planning thus provides a significant benefit to the formulation of research plans and also enables the planning and development of a compatible AdvSMR licensing framework, should significant modification be required.

Advanced Reactor Technology -- Regulatory Technology Development Plan (RTDP)

Energy Technology Data Exchange (ETDEWEB)

Moe, Wayne Leland [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-05-01

importance of key DOE reactor research initiatives should be assessed early in the technology development process. Quality assurance requirements supportive of later licensing activities must also be attached to important research activities to ensure resulting data is usable in that context. Early regulatory analysis and licensing approach planning thus provides a significant benefit to the formulation of research plans and also enables the planning and development of a compatible AdvSMR licensing framework, should significant modification be required.

Safety improvement plant modifications at Forsmark 3, 1986-1995

Energy Technology Data Exchange (ETDEWEB)

Kjellander, M. [Kaernkraftsaekerhet och utbildning, Nykoeping (Sweden)

1998-10-01

All important plant modifications implemented in safety-related equipment or software at Forsmark 3 are compiled in this report. The report covers the period from the start of commercial operation in 1985 up to and including 1995. The plant modifications, which were carried out by different suppliers during the guarantee period, are not included in the report since they have not been administered by the Forsmark organisation. The report contains references to relevant modification notices and to files and file divider numbers. These data refer to the Safety Department central archives. The report is based on Forsmark 3 Technical Specifications (STF) which means that Chapter 3 is divided into the same sections as in the STF. Modifications, which cannot be directly attributed to any specific STF chapter, and major modifications are described separately

Chemical modification of b-lactoglobulin by quinones

Directory of Open Access Journals (Sweden)

DUSAN SLADIC

2003-05-01

Full Text Available The avarone/avarol quinone/hydroquinone couple, as well as their derivatives show considerable antitumor activity. In this work, covalent modifications of b-lactoglobulin, isolated from cow milk, by avarone, its model compound 2-tert-butyl-1,4-benzoquinone, and several of their alkylthio derivatives were studied. The techniques applied for assaying the modifications were: UV/VIS spectrophotometry, SDS PAGE and isoelectrofocusing. The results of the SDS PAGE suggest that polymerisation of the protein occurs. The shift of the pI of the protein upon modification toward lower values indicates that lysine amino groups are the principal site of the reaction of b-lactoglobulin with the quinones.

OCCASIONAL ADNOMINAL IDIOM MODIFICATION - A COGNITIVE LINGUISTIC APPROACH

Directory of Open Access Journals (Sweden)

Andreas Langlotz

2006-06-01

Full Text Available occasional Adnominal Idiom Modification - A Cognitive Linguistic Approach From a cognitive-linguistic perspective, this paper explores alternative types of adnoniinal modification in occasional variants of English verbal idioms. Being discussed against data extracted from the British National Corpiis (BNC, the model claims that in idioni-production idiomatic constructions are activated as complex linguistic schemas to code a context-specific target-conceptualisation. Adnominal pre- and postmodifications are one specific form of creative alteration to adapt the idiom for this purpose. Semantically, idiom-interna1 NPextension is not a uniforni process. It is necessary to distinguish two systematic types of adnominal modification: external and internal modification (Ernst 1981. While external NPmodification has adverbial function, ¡.e. it modifies the idiom as a unit, internal modification directly applies to the head-noun and thus depends on the degree of motivation and analysability of a given idiom. Following the cognitive-linguistic framework, these dimensions of idiom-transparency result from the language user's ability to remotivate the bipartite semantic structure by conceptual metaphors and metonymies.

42 CFR 412.72 - Modification of base-year costs.

Science.gov (United States)

2010-10-01

... 42 Public Health 2 2010-10-01 2010-10-01 false Modification of base-year costs. 412.72 Section 412... Modification of base-year costs. (a) Bases for modification of base-year costs. Base-year costs as determined... before November 16, 1983 has until November 15, 1983 to request its intermediary to reestimate its base...

Journal of Food Technology in Africa - Vol 9, No 1 (2004)

African Journals Online (AJOL)

The Effects of Technological Modifications on the Fermentation of Borde, an Ethiopian Traditional Fermented Cereal Beverage · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Kebede Abegaz, Thor Langsrud, Fedadu Beyene, Judith A Narvhus, 3-12 ...

Curricular Implications of Virtual World Technology: A Review of Business Applications

Science.gov (United States)

Cyphert, Dale; Wurtz, M. Susan; Duclos, Leslie K.

2013-01-01

As business organizations grow increasingly virtual, traditional principles of organizational communication require examination and modification. This article considers the curricular implications of the growing business uses of virtual world technology through three different lenses--students as employee-users, students as strategic designers and…

Tribological effects of polymer surface modification through plastic

Indian Academy of Sciences (India)

Tribological effects of polymer surface modification through plastic deformation. K O Low K J Wong ... In this regard, a surface modification technique through plastic deformation has been implemented. ... Bulletin of Materials Science | News.

Radiation processing technology in the 21st century

International Nuclear Information System (INIS)

Miyuki Hagiwara

1997-01-01

The address discusses the following issue - towards the 21st century, we are required more and more to create innovative technologies to solve problems about environment, energy, natural resources, materials, health care, food and others which are the great concern to human beings. For the radiation processing technology to survive, it will be required to provide answers to those problems. The use of radiation of polymer modification will remain as an important field of the radiation application. Some other promising polymer processing can be cited as those which will grow in near future; for environment technology - polymeric fibers grafted with ion exchange residues to remove toxic metals for cleaning industrial waste water; For health care technology - crosslinked polyvinylalcohol hydrogel for wound dressing (irradiation of hydrogel); For high performance materials technology - less toxic crosslinked natural rubber latex (irradiation of emulsion), abrasion resistant crosslinked PTFE (irradiation at high temperature)

Nuclear Plant Modification in a Risk-Informed Environment

International Nuclear Information System (INIS)

Gallucci, Raymond H.V.

2002-01-01

This paper examines a specific nuclear power plant modification performed in a risk-informed regulatory environment. It quantifies both the permanent and temporary effects of the modification, and performs a cost-benefit evaluation. (authors)

Mixed Waste Integrated Program emerging technology development

Energy Technology Data Exchange (ETDEWEB)

Berry, J.B. [Oak Ridge National Lab., TN (United States); Hart, P.W. [USDOE, Washington, DC (United States)

1994-06-01

The US Department of Energy (DOE) is responsible for the management and treatment of its mixed low-level wastes (MLLW). MLLW are regulated under both the Resource Conservation and Recovery Act and various DOE orders. Over the next 5 years, DOE will manage over 1.2 m{sup 3} of MLLW and mixed transuranic (MTRU) wastes. In order to successfully manage and treat these mixed wastes, DOE must adapt and develop characterization, treatment, and disposal technologies which will meet performance criteria, regulatory approvals, and public acceptance. Although technology to treat MLLW is not currently available without modification, DOE is committed to developing such treatment technologies and demonstrating them at the field scale by FY 1997. The Office of Research and Development`s Mixed Waste Integrated Program (MWIP) within the DOE Office of Environmental Management (EM), OfFice of Technology Development, is responsible for the development and demonstration of such technologies for MLLW and MTRU wastes. MWIP advocates and sponsors expedited technology development and demonstrations for the treatment of MLLW.

Highly specific detection of genetic modification events using an enzyme-linked probe hybridization chip.

Science.gov (United States)

Zhang, M Z; Zhang, X F; Chen, X M; Chen, X; Wu, S; Xu, L L

2015-08-10

The enzyme-linked probe hybridization chip utilizes a method based on ligase-hybridizing probe chip technology, with the principle of using thio-primers for protection against enzyme digestion, and using lambda DNA exonuclease to cut multiple PCR products obtained from the sample being tested into single-strand chains for hybridization. The 5'-end amino-labeled probe was fixed onto the aldehyde chip, and hybridized with the single-stranded PCR product, followed by addition of a fluorescent-modified probe that was then enzymatically linked with the adjacent, substrate-bound probe in order to achieve highly specific, parallel, and high-throughput detection. Specificity and sensitivity testing demonstrated that enzyme-linked probe hybridization technology could be applied to the specific detection of eight genetic modification events at the same time, with a sensitivity reaching 0.1% and the achievement of accurate, efficient, and stable results.

Identifying modifications in RNA by MALDI mass spectrometry

DEFF Research Database (Denmark)

Douthwaite, Stephen; Kirpekar, Finn

2007-01-01

as RNA modifications added in cell-free in vitro systems. MALDI-MS is particularly useful in cases in which other techniques such as those involving primer extension or chromatographic analyses are not practicable. To date, MALDI-MS has been used to localize rRNA modifications that are involved......Posttranscriptional modifications on the base or sugar of ribonucleosides generally result in mass increases that can be measured by mass spectrometry. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is a direct and accurate means of determining the masses of RNAs. Mass...... spectra produced by MALDI are relatively straightforward to interpret, because they are dominated by singly charged ions, making it possible to analyze complex mixtures of RNA oligonucleotides ranging from trinucleotides up to 20-mers. Analysis of modifications within much longer RNAs, such as ribosomal...

The status of nuclear power technology

International Nuclear Information System (INIS)

Calori, F.

1976-01-01

A survey is presented of the present state of development concerning nuclear power technology, and the prospects of a modified future development of nuclear energy in the world are dealt with, modification being necessary on account of altered conditions in the development of the energy economy. Projections are made for the development of the fuel market taking into account the quantities and costs for the various steps of the fuel cycle. (UA) [de

Generation and genetic modification of induced pluripotent stem cells.

Science.gov (United States)

Schambach, Axel; Cantz, Tobias; Baum, Christopher; Cathomen, Toni

2010-07-01

The generation of induced pluripotent stem cells (iPSCs) enabled by exogenous expression of the canonical Oct4, Sox2, Klf4 and c-Myc reprogramming factors has opened new ways to create patient- or disease-specific pluripotent cells. iPSCs represent an almost inexhaustible source of cells for targeted differentiation into somatic effector cells and hence are likely to be invaluable for therapeutic applications and disease-related research. After an introduction on the biology of reprogramming we cover emerging technological advances, including new reprogramming approaches, small-molecule compounds and tailored genetic modification, and give an outlook towards potential clinical applications of iPSCs. Although this field is progressing rapidly, reprogramming is still an inefficient process. The reader will learn about innovative tools to generate patient-specific iPSCs and how to modify these established lines in a safe way. Ideally, the disease-causing mutation is edited directly in the genome using novel technologies based on artificial nucleases, such as zinc-finger nucleases. Human iPSCs create fascinating options with regard to disease modeling, drug testing, developmental studies and therapeutic applications. However, important hurdles have to be taken and more efficient protocols to be established to achieve the ambitious goal of bringing iPSCs into clinical use.

Albumin modification and fragmentation in renal disease.

Science.gov (United States)

Donadio, Carlo; Tognotti, Danika; Donadio, Elena

2012-02-18

Albumin is the most important antioxidant substance in plasma and performs many physiological functions. Furthermore, albumin is the major carrier of endogenous molecules and exogenous ligands. This paper reviews the importance of post-translational modifications of albumin and fragments thereof in patients with renal disease. First, current views and controversies on renal handling of proteins, mainly albumin, will be discussed. Post-translational modifications, namely the fragmentation of albumin found with proteomic techniques in nephrotic patients, diabetics, and ESRD patients will be presented and discussed. It is reasonable to hypothesize that proteolytic fragmentation of serum albumin is due to a higher susceptibility to proteases, induced by oxidative stress. The clinical relevance of the fragmentation of albumin has not yet been established. These modifications could affect some physiological functions of albumin and have a patho-physiological role in uremic syndrome. Proteomic analysis of serum allows the identification of over-expressed proteins and can detect post-translational modifications of serum proteins, hitherto hidden, using standard laboratory techniques. Copyright © 2011 Elsevier B.V. All rights reserved.

Covalent Surface Modifications of Carbon Nanotubes.

Energy Technology Data Exchange (ETDEWEB)

Pavia Sanders, Adriana [Sandia National Lab. (SNL-CA), Livermore, CA (United States); O' Bryan, Greg [Sandia National Lab. (SNL-CA), Livermore, CA (United States)

2017-07-01

A report meant to document the chemistries investigated by the author for covalent surface modification of CNTs. Oxidation, cycloaddition, and radical reactions were explored to determine their success at covalently altering the CNT surface. Characterization through infrared spectroscopy, Raman spectroscopy, and thermo gravimetric analysis was performed in order to determine the success of the chemistries employed. This report is not exhaustive and was performed for CNT surface modification exploration as it pertains to the "Next Gen" project.

Immunologic applications of conditional gene modification technology in the mouse.

Science.gov (United States)

Sharma, Suveena; Zhu, Jinfang

2014-04-02

Since the success of homologous recombination in altering mouse genome and the discovery of Cre-loxP system, the combination of these two breakthroughs has created important applications for studying the immune system in the mouse. Here, we briefly summarize the general principles of this technology and its applications in studying immune cell development and responses; such implications include conditional gene knockout and inducible and/or tissue-specific gene over-expression, as well as lineage fate mapping. We then discuss the pros and cons of a few commonly used Cre-expressing mouse lines for studying lymphocyte development and functions. We also raise several general issues, such as efficiency of gene deletion, leaky activity of Cre, and Cre toxicity, all of which may have profound impacts on data interpretation. Finally, we selectively list some useful links to the Web sites as valuable mouse resources. Copyright © 2014 John Wiley & Sons, Inc.

Technologies for evaluating fish passage through turbines

Energy Technology Data Exchange (ETDEWEB)

Weiland, Mark A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Carlson, Thomas J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2003-10-01

This study evaluated the feasibility of two types of technologies to observe fish and near neutrally buoyant drogues as they move through hydropower turbines. Existing or reasonably modified light-emitting and ultrasonic technologies were used to observe flow patterns, the response of fish to flow, and interactions between fish and turbine structures with good spatial and temporal accuracy. This information can be used to assess the biological benefits of turbine design features such as reductions in gaps at the tips and hub of turbine runner blades, reshaping wicket gates and stay vanes, modifications to draft tube splitter piers, and design changes that enhance egress through the powerhouse and tailrace.

Engineerig of structural modifications for operating nuclear plants

International Nuclear Information System (INIS)

Duffy, T.J.; Gazda, P.A.

1983-01-01

The engineering of structural modifications for operating nuclear plants offers many challenges in the areas of scheduling of work, field adjustments, and engineering staff planning. The scheduling of structural modification work for operating nuclear plants is normally closely tied to planned or unplanned outages of the plant. Coordination between the structural engineering effort, the operating plant staff, and the contractor who will be performing the modifications is essential to ensure that all work can be completed within the allotted time. Due to the inaccessibility of areas in operating plants or the short time available to perform the structural engineering in the case of an unscheduled outage, field verification of a design is not always possible prior to initiating the construction of the modification. This requires the structural engineer to work closely with the contractor to promptly resolve problems due to unanticipated interferences or material procurement that may arise during the course of construction. The engineering staff planning for structural modifications at an operating nuclear plant must be flexible enough to permit rapid response to the common 'fire drills', but controlled enough to assure technically correct designs and minimize the expenditure of man-hours and resulting engineering cost. (orig.)

A model technology transfer program for independent operators: Kansas Technology Transfer Model (KTTM)

Energy Technology Data Exchange (ETDEWEB)

Schoeling, L.G.

1993-09-01

This report describes the development and testing of the Kansas Technology Transfer Model (KTTM) which is to be utilized as a regional model for the development of other technology transfer programs for independent operators throughout oil-producing regions in the US. It describes the linkage of the regional model with a proposed national technology transfer plan, an evaluation technique for improving and assessing the model, and the methodology which makes it adaptable on a regional basis. The report also describes management concepts helpful in managing a technology transfer program. The original Tertiary Oil Recovery Project (TORP) activities, upon which the KTTM is based, were developed and tested for Kansas and have proved to be effective in assisting independent operators in utilizing technology. Through joint activities of TORP and the Kansas Geological Survey (KGS), the KTTM was developed and documented for application in other oil-producing regions. During the course of developing this model, twelve documents describing the implementation of the KTTM were developed as deliverables to DOE. These include: (1) a problem identification (PI) manual describing the format and results of six PI workshops conducted in different areas of Kansas, (2) three technology workshop participant manuals on advanced waterflooding, reservoir description, and personal computer applications, (3) three technology workshop instructor manuals which provides instructor material for all three workshops, (4) three technologies were documented as demonstration projects which included reservoir management, permeability modification, and utilization of a liquid-level acoustic measuring device, (5) a bibliography of all literature utilized in the documents, and (6) a document which describes the KTTM.

78 FR 9636 - Airworthiness Directives; Cessna Aircraft Company Airplanes

Science.gov (United States)

2013-02-11

...)(ix) through (k)(3)(xiii) of this AD. (i) Open the battery door. (ii) Disconnect the main battery... warning tag that reads: ``WARNING: Do not connect the battery connector during the maintenance in progress... external power receptacle. (xii) Connect the battery and restore electrical power to the airplane. (xiii...

Modification of cadmium pigments for colouring of polyolefins

International Nuclear Information System (INIS)

Kalinskaya, T.V.; Livshits, I.M.

1976-01-01

Modification conditions are studied of cadmium pigments, obtained by different methods, aliphatic acids(C 5 , C 8 and C 17 ). It is found, that cadmium pigments can adsorb acids with the number of atoms of carbon not less than 8. Stearic acid adsorption on lemon cadmium pigment taken as an example has shown the efficiency of pigment modification influence on its dispersancy in non-polar medium. Modification of yellow cadmium pigments of stearic acid makes possible to obtain pigment output forms ensuring a good particle distribution during polyolefine colouring

NATO Technology: From Gap to Divergence? (Defense Horizons, July 2004)

National Research Council Canada - National Science Library

Daniel, Donald

2004-01-01

.... With only slight modifications (not additions) to current total defense expenditures, and using funds that will be available as they restructure their forces, European members could not only double their current investment but take significant strides to ensure that they are not left behind in a world dominated by technology.

Advances in vacuum extraction technology for effective subsurface remediation

International Nuclear Information System (INIS)

Dodson, M.E.; Pezzullo, J.A.; Piniewski, R.J.

1994-01-01

Vacuum extraction technology has become one of the most widely acclaimed methods for remediating soils contaminated by petroleum hydrocarbons and volatile organic compounds. Removal of the source of contamination in the soil is often the first step in effective control of groundwater contamination. Though originally thought effective only for removal of light-end hydrocarbons from permeable vadose-zone soils, vacuum extraction can now be adapted to address situations of low-permeable soils, heavier-end hydrocarbons and groundwater contamination. This paper reviews four innovative modifications to the vacuum extraction process and how they solve a wide variety of subsurface contamination problems. The modifications, or processes, reviewed include: vacuum-extraction-enhanced bioremediation, groundwater sparging, pneumatic soil fracturing, and soil heating

CFD based exploration of the dry-low-NOx hydrogen micromix combustion technology at increased energy densities

Directory of Open Access Journals (Sweden)

A. Haj Ayed

2017-03-01

The study reveals great optimization potential of the micromix combustion technology with respect to the DLN characteristics and gives insight into the impact of geometry modifications on flame structure and NOx emission. This allows to further increase the energy density of the micromix burners and to integrate this technology in industrial gas turbines.

tRNA modification profiles of the fast-proliferating cancer cells

Energy Technology Data Exchange (ETDEWEB)

Dong, Chao; Niu, Leilei; Song, Wei [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Department of Obstetrics and Gynecology, Peking University Third Hospital, Peking University, Beijing 100191 (China); Xiong, Xin; Zhang, Xianhua [Departmentof Pharmacy, Peking University Third Hospital, Peking University, Beijing 100191 (China); Zhang, Zhenxi; Yang, Yi; Yi, Fan [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Department of Obstetrics and Gynecology, Peking University Third Hospital, Peking University, Beijing 100191 (China); Zhan, Jun; Zhang, Hongquan [Department of Anatomy, Histology and Embryology, Laboratory of Molecular Cell Biology and Tumor Biology, Peking University, Beijing 100191 (China); Yang, Zhenjun; Zhang, Li-He [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Department of Obstetrics and Gynecology, Peking University Third Hospital, Peking University, Beijing 100191 (China); Zhai, Suodi [Departmentof Pharmacy, Peking University Third Hospital, Peking University, Beijing 100191 (China); Li, Hua, E-mail: huali88@sina.com [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Department of Obstetrics and Gynecology, Peking University Third Hospital, Peking University, Beijing 100191 (China); Ye, Min, E-mail: yemin@bjmu.edu.cn [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Department of Obstetrics and Gynecology, Peking University Third Hospital, Peking University, Beijing 100191 (China); Du, Quan, E-mail: quan.du@pku.edu.cn [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Department of Obstetrics and Gynecology, Peking University Third Hospital, Peking University, Beijing 100191 (China)

2016-08-05

Despite the recent progress in RNA modification study, a comprehensive modification profile is still lacking for mammalian cells. Using a quantitative HPLC/MS/MS assay, we present here a study where RNA modifications are examined in term of the major RNA species. With paired slow- and fast-proliferating cell lines, distinct RNA modification profiles are first revealed for diverse RNA species. Compared to mRNAs, increased ribose and nucleobase modifications are shown for the highly-structured tRNAs and rRNAs, lending support to their contribution to the formation of high-order structures. This study also reveals a dynamic tRNA modification profile in the fast-proliferating cells. In addition to cultured cells, this unique tRNA profile has been further confirmed with endometrial cancers and their adjacent normal tissues. Taken together, the results indicate that tRNA is a actively regulated RNA species in the fast-proliferating cancer cells, and suggest that they may play a more active role in biological process than expected. -- Highlights: •RNA modifications were first examined in term of the major RNA species. •A dynamic tRNA modifications was characterized for the fast-proliferating cells. •The unique tRNA profile was confirmed with endometrial cancers and their adjacent normal tissues. •tRNA was predicted as an actively regulated RNA species in the fast-proliferating cancer cells.

tRNA modification profiles of the fast-proliferating cancer cells

International Nuclear Information System (INIS)

Dong, Chao; Niu, Leilei; Song, Wei; Xiong, Xin; Zhang, Xianhua; Zhang, Zhenxi; Yang, Yi; Yi, Fan; Zhan, Jun; Zhang, Hongquan; Yang, Zhenjun; Zhang, Li-He; Zhai, Suodi; Li, Hua; Ye, Min; Du, Quan

2016-01-01

Despite the recent progress in RNA modification study, a comprehensive modification profile is still lacking for mammalian cells. Using a quantitative HPLC/MS/MS assay, we present here a study where RNA modifications are examined in term of the major RNA species. With paired slow- and fast-proliferating cell lines, distinct RNA modification profiles are first revealed for diverse RNA species. Compared to mRNAs, increased ribose and nucleobase modifications are shown for the highly-structured tRNAs and rRNAs, lending support to their contribution to the formation of high-order structures. This study also reveals a dynamic tRNA modification profile in the fast-proliferating cells. In addition to cultured cells, this unique tRNA profile has been further confirmed with endometrial cancers and their adjacent normal tissues. Taken together, the results indicate that tRNA is a actively regulated RNA species in the fast-proliferating cancer cells, and suggest that they may play a more active role in biological process than expected. -- Highlights: •RNA modifications were first examined in term of the major RNA species. •A dynamic tRNA modifications was characterized for the fast-proliferating cells. •The unique tRNA profile was confirmed with endometrial cancers and their adjacent normal tissues. •tRNA was predicted as an actively regulated RNA species in the fast-proliferating cancer cells.

Vacuum-based surface modification of organic and metallic substrates

Science.gov (United States)

Torres, Jessica

Surface physico-chemical properties play an important role in the development and performance of materials in different applications. Consequently, understanding the chemical and physical processes involved during surface modification strategies is of great scientific and technological importance. This dissertation presents results from the surface modification of polymers, organic films and metallic substrates with reactive species, with the intent of simulating important modification processes and elucidating surface property changes of materials under different environments. The reactions of thermally evaporated copper and titanium with halogenated polytetrafluoroethylene (PTFE) and polyvinyl chloride (PVC) are used to contrast the interaction of metals with polymers. Results indicate that reactive metallization is thermodynamically favored when the metal-halogen bond strength is greater than the carbon-halogen bond strength. X-ray post-metallization treatment results in an increase in metal-halide bond formation due to the production of volatile halogen species in the polymer that react with the metallic overlayer. The reactions of atomic oxygen (AO) and atomic chlorine with polyethylene (PE) and self-assembled monolayers (SAMs) films were followed to ascertain the role of radical species during plasma-induced polymer surface modification. The reactions of AO with X-ray modified SAMs are initially the dominated by the incorporation of new oxygen containing functionality at the vacuum/film interface, leading to the production of volatile carbon containing species such as CO2 that erodes the hydrocarbon film. The reaction of atomic chlorine species with hydrocarbon SAMs, reveals that chlorination introduces C-Cl and C-Cl2 functionalities without erosion. A comparison of the reactions of AO and atomic chlorine with PE reveal a maximum incorporation of the corresponding C-O and C-Cl functionalities at the polymer surface. A novel method to prepare phosphorous

Body modification and substance use in adolescents: is there a link?

Science.gov (United States)

Brooks, Traci L; Woods, Elizabeth R; Knight, John R; Shrier, Lydia A

2003-01-01

To describe the characteristics of body modification among adolescents and to determine whether adolescents who engage in body modification are more likely to screen positive for alcohol and other drug problems than those who do not. Adolescents aged 14 to 18 years presenting to an urban adolescent clinic for routine health care completed a questionnaire about body modification and a substance use assessment battery that included the 17-item Problem Oriented Screening Instrument for Teenagers Alcohol/Drug Use and Abuse Scale (POSIT-ADS). Body modification was defined as piercings (other than one pair of bilateral earlobe piercings in females), tattoos, scarification, and branding. Problem substance use was defined as a POSIT-ADS score > or =1. Data were analyzed using logistic regression to determine whether the presence of body modification was an independent predictor of problem substance use. The 210 participants had a mean (+/- SD) age of 16.0 (+/- 1.4) years and 63% were female. One hundred adolescents (48%) reported at least one body modification; girls were more likely than boys to have body modification (59% vs. 28%, p branding; 21 (10%) had more than one type of body modification. These were in a variety of locations, most commonly the ear and the nose (piercings) or the extremities (tattoos). One-third of the sample (33%) screened positive for problem substance use on the POSIT-ADS questionnaire. Controlling for age, adolescents with body modification had 3.1 times greater odds of problem substance use than those without body modification (95% CI 1.7, 5.8). Body modification was associated with self-reported problem alcohol and other drug use among middle adolescents presenting for primary care. More research is needed to determine the clinical and sociocultural significance of body modification and its relationship to substance use in this population. Copyright Society for Adolescent Medicine, 2003

LISA Beyond Einstein: From the Big Bang to Black Holes. LISA Technology Development at GSFC

Science.gov (United States)

Thorpe, James Ira

2008-01-01

This viewgraph presentation reviews the work that has been ongoing at the Goddard Space Flight Center (GSFC) in the development of the technology to be used in the Laser Interferometer Space Antenna (LISA) spacecrafts. The prime focus of LISA technology development efforts at NASA/GSFC has been in LISA interferometry. Specifically efforts have been made in the area of laser frequency noise mitigation. Laser frequency noise is addressed through a combination of stabilization and common-mode rejection. Current plans call for two stages of stabilization, pre-stabilization to a local frequency reference and further stabilization using the constellation as a frequency reference. In order for these techniques to be used simultaneously, the pre-stabilization step must provide an adjustable frequency offset. This presentation reports on a modification to the standard modulation/demodulation technique used to stabilize to optical cavities that generates a frequency-tunable reference from a fixed length cavity. This technique requires no modifications to the cavity itself and only minor modifications to the components. The measured noise performance and dynamic range of the laboratory prototype meet the LISA requirements.

Design definition study of a lift/cruise fan technology V/STOL aircraft. Volume 2: Technology aircraft

Science.gov (United States)

1975-01-01

Technology flight vehicles were defined for three different approaches which demonstrate the concept and characteristics of the multipurpose aircraft established for Navy missions. The propulsion system used for the various technology flight vehicles was representative of that established for the multipurpose aircraft. Existing J97-GE100 gas generators were selected based on cost, availability and exhaust characteristics. The LF459 fans were also selected and are compatible with both technology and operational vehicles. To comply with the design guideline safety criteria, it was determined that three gas generators were required to provide engine out safety in the hover flight mode. The final propulsion system established for the technology aircraft was three existing J97 gas generators powering three LF459 fans. Different aircraft candidates were evaluated for application to the three designated design approaches. Each configuration was evaluated on the basis of (1) propulsion system integration, (2) modification required, (3) pilot's visibility, (4) payload volume, and (5) adaptability to compatible location of center-of-gravity/aerodynamic center and thrust center.

Nanofibrillated Cellulose Surface Modification: A Review

Directory of Open Access Journals (Sweden)

Julien Bras

2013-05-01

Full Text Available Interest in nanofibrillated cellulose (NFC has increased notably over recent decades. This bio-based nanomaterial has been used essentially in bionanocomposites or in paper thanks to its high mechanical reinforcement ability or barrier property respectively. Its nano-scale dimensions and its capacity to form a strong entangled nanoporous network have encouraged the emergence of new high-value applications. It is worth noting that chemical surface modification of this material can be a key factor to achieve a better compatibility with matrices. In order to increase the compatibility in different matrices or to add new functions, surface chemical modification of NFC appears to be the prior choice to conserve its intrinsic nanofibre properties. In this review, the authors have proposed for the first time an overview of all chemical grafting strategies used to date on nanofibrillated cellulose with focus on surface modification such as physical adsorption, molecular grafting or polymer grafting.

Roman sophisticated surface modification methods to manufacture silver counterfeited coins

Science.gov (United States)

Ingo, G. M.; Riccucci, C.; Faraldi, F.; Pascucci, M.; Messina, E.; Fierro, G.; Di Carlo, G.

2017-11-01

By means of the combined use of X-ray photoelectron spectroscopy (XPS), optical microscopy (OM) and scanning electron microscopy (SEM) coupled with energy dispersive X-ray spectroscopy (EDS) the surface and subsurface chemical and metallurgical features of silver counterfeited Roman Republican coins are investigated to decipher some aspects of the manufacturing methods and to evaluate the technological ability of the Roman metallurgists to produce thin silver coatings. The results demonstrate that over 2000 ago important advances in the technology of thin layer deposition on metal substrates were attained by Romans. The ancient metallurgists produced counterfeited coins by combining sophisticated micro-plating methods and tailored surface chemical modification based on the mercury-silvering process. The results reveal that Romans were able systematically to chemically and metallurgically manipulate alloys at a micro scale to produce adherent precious metal layers with a uniform thickness up to few micrometers. The results converge to reveal that the production of forgeries was aimed firstly to save expensive metals as much as possible allowing profitable large-scale production at a lower cost. The driving forces could have been a lack of precious metals, an unexpected need to circulate coins for trade and/or a combinations of social, political and economic factors that requested a change in money supply. Finally, some information on corrosion products have been achieved useful to select materials and methods for the conservation of these important witnesses of technology and economy.

Quality planning for major plant design modifications

International Nuclear Information System (INIS)

Dulee, R.J.

1988-01-01

This paper reviews the approach and activities undertaken by Public Service Electric and Gas Company's (PSE and G's) nuclear quality assurance (QA) department to support major plant design modifications conducted during refueling outages at Salem Generating Station. It includes the planning and implementation of quality plans developed to provide both QA and quality control (QC) coverage of modification performed by contracted service organizations

Modification of the perturbative QCD towards confinement

International Nuclear Information System (INIS)

Arodz, H.

1981-01-01

Modification of the low momentum behaviour of the perturbative SU(2) gauge theory is proposed. The modification is closely related (although not equivalent) to a nonstandard choice of boundary condition for the Euclidean 2-point gluonic Green function. In the resulting theory already single graphs lead to the confining potential between heavy, static quarks, V(r) = ar 2 for r → infinity. (author)

Practical background modification fermented beverage technology for the formation of defined functional properties

Directory of Open Access Journals (Sweden)

V. V. Botvinnikova

2016-01-01

Full Text Available The problem of provision of population with dairy products is escalating due to the fact that today, throughout the world, particularly in Russia, there is a shortage of milk as raw material, increasing every year. In the future, the consumption of milk and dairy products will continue to outpace growth in milk production is solid. To solve this problem, domestic producers need to find new ways to increase production of raw milk and improve the consumer and functional properties of fermented dairy products. The work was proposed the use of acoustic effects of ultrasound, triggered by the ultrasound, the technological model UTA ABOUT, 4/22 OM (frequency mechanical vibrations 22 ± 1,65 kHz. The main factors determining consumer characteristics, were taken physico-chemical parameters, structural and mechanical characteristics and the accumulation of minor biologically active substances – kefiran. In the study was obtained results confirming the necessity of using ultrasonic impact (RAS in the production technology of dairy products.

Surface modification of ultra thin PES-zeolite using thermal annealing to increase flux and rejection of produced water treatment

Energy Technology Data Exchange (ETDEWEB)

Kusworo, T. D., E-mail: tdkusworo@che.undip.ac.id; Widayat,; Pradini, A. W.; Armeli, Y. P. [Department of Chemical Engineering, University of Diponegoro Prof. Soedarto, Tembalang, Semarang, 50239, Phone/Fax : (024) 7460058 (Indonesia)

2015-12-29

Membrane technology is an alternative of water treatment based on filtration that is being developed. Surface Modification using heat treatment has been investigated to improve the performance of ultra thin PES-Zeolite nanocomposite membrane for produced water treatment from Pertamina Balongan. Two types of membranes with surface modification and without modification were prepared to study the effect of surface modification on its permeation properties. Asymmetric ultra thin PES-Zeolite nanocomposite membrane for produced water treatment was casted using the dry/wet phase inversion technique from dope solutions containing polyethersulfone, N-methyl-2-pyrrolidone (NMP) as a solvent and zeolite as a filler. Experimental results showed that the heat treatment at near glass transition temperature was increase the rejection of COD, Turbidity and ion Ca{sup 2+}. The better adherence of zeolite particles in the polymer matrix combined with formation of charge transfer complexes (CTCs) and cross-linking might be the main factors to enhance the percent of rejection. Field emission scanning electron microscopy (FESEM) micrographs showed that the selective layer and the substructure of PES-zeolite membrane became denser and more compact after the heat treatment. The FESEM micrographs also showed that the heat treatment was increased the adherence of zeolite particle and polymer. Membranes treated at 180 °C for 15 seconds indicated increase the rejection and small decrease in flux for produced water treatment.

Mechanisms of behavior modification in clinical behavioral medicine in China.

Science.gov (United States)

Yang, Zhiyin; Su, Zhonghua; Ji, Feng; Zhu, Min; Bai, Bo

2014-08-01

Behavior modification, as the core of clinical behavioral medicine, is often used in clinical settings. We seek to summarize behavior modification techniques that are commonly used in clinical practice of behavioral medicine in China and discuss possible biobehavioral mechanisms. We reviewed common behavior modification techniques in clinical settings in China, and we reviewed studies that explored possible biobehavioral mechanisms. Commonly used clinical approaches of behavior modification in China include behavior therapy, cognitive therapy, cognitive-behavioral therapy, health education, behavior management, behavioral relaxation training, stress management intervention, desensitization therapy, biofeedback therapy, and music therapy. These techniques have been applied in the clinical treatment of a variety of diseases, such as chronic diseases, psychosomatic diseases, and psychological disorders. The biobehavioral mechanisms of these techniques involve the autonomic nervous system, neuroendocrine system, neurobiochemistry, and neuroplasticity. Behavior modification techniques are commonly used in the treatment of a variety of somatic and psychological disorders in China. Multiple biobehavioral mechanisms are involved in successful behavior modification.

Pnp gene modification for improved xylose utilization in Zymomonas

Science.gov (United States)

Caimi, Perry G G; Qi, Min; Tao, Luan; Viitanen, Paul V; Yang, Jianjun

2014-12-16

The endogenous pnp gene encoding polynucleotide phosphorylase in the Zymomonas genome was identified as a target for modification to provide improved xylose utilizing cells for ethanol production. The cells are in addition genetically modified to have increased expression of ribose-5-phosphate isomerase (RPI) activity, as compared to cells without this genetic modification, and are not limited in xylose isomerase activity in the absence of the pnp modification.

Comparison of several innovative bridge cable surface modifications

DEFF Research Database (Denmark)

Kleissl, Kenneth; Georgakis, Christos T.

Over the last two decades, several bridge cable manufacturers have introduced surface modifications on the high-density polyethylene (HDPE) sheathing that is installed for the protection of inner cable strands or wires. The modifications are based on research undertaken predominantly in Europe...

Turbine imaging technology assessment

Energy Technology Data Exchange (ETDEWEB)

Moursund, R. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Carlson, T. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2004-12-01

The goal of this project was to identify and evaluate imaging technologies for observing juvenile fish within a Kaplan turbine, and specifically that would enable scientists to determine mechanisms of fish injury within an operating turbine unit. This report documents the opportunities and constraints for observing juvenile fish at specific locations during turbine passage. These observations were used to make modifications to dam structures and operations to improve conditions for fish passage while maintaining or improving hydropower production. The physical and hydraulic environment that fish experience as they pass through the hydroelectric plants were studied and the regions with the greatest potential for injury were defined. Biological response data were also studied to determine the probable types of injuries sustained in the turbine intake and what types of injuries are detectable with imaging technologies. The study grouped injury-causing mechanisms into two categories: fluid (pressure/cavitation, shear, turbulence) and mechanical (strike/collision, grinding/pinching, scraping). The physical constraints of the environment, together with the likely types of injuries to fish, provided the parameters needed for a rigorous imaging technology evaluation. Types of technology evaluated included both tracking and imaging systems using acoustic technologies (such as sonar and acoustic tags) and optic technologies (such as pulsed-laser videography, which is high-speed videography using a laser as the flash). Criteria for determining image data quality such as frame rate, target detectability, and resolution were used to quantify the minimum requirements of an imaging sensor.

W. Richard Scott, Institutions and Organizations: Ideas, Interests, and Identities

DEFF Research Database (Denmark)

Jakobsen, Michael

2014-01-01

Book review of: W. Richard Scott: Institutions and Organizations: Ideas, Interests, and Identities. 4th edition. Thousand Oaks, CA: SAGE Publications, 2014. xiii, 345 pp.......Book review of: W. Richard Scott: Institutions and Organizations: Ideas, Interests, and Identities. 4th edition. Thousand Oaks, CA: SAGE Publications, 2014. xiii, 345 pp....

Advanced Reactor Technology -- Regulatory Technology Development Plan (RTDP)

International Nuclear Information System (INIS)

Moe, Wayne Leland

2015-01-01

technology development studies, the anticipated regulatory importance of key DOE reactor research initiatives should be assessed early in the technology development process. Quality assurance requirements supportive of later licensing activities must also be attached to important research activities to ensure resulting data is usable in that context. Early regulatory analysis and licensing approach planning thus provides a significant benefit to the formulation of research plans and also enables the planning and development of a compatible AdvSMR licensing framework, should significant modification be required.

Modification of enzymes by use of high-pressure homogenization.

Science.gov (United States)

Dos Santos Aguilar, Jessika Gonçalves; Cristianini, Marcelo; Sato, Helia Harumi

2018-07-01

High-pressure is an emerging and relatively new technology that can modify various molecules. High-pressure homogenization (HPH) has been used in several studies on protein modification, especially in enzymes used or found in food, from animal, plant or microbial resources. According to the literature, the enzymatic activity can be modulated under pressure causing inactivation, stabilization or activation of the enzymes, which, depending on the point of view could be very useful. Homogenization can generate changes in the structure of the enzyme modifying various chemical bonds (mainly weak bonds) causing different denaturation levels and, consequently, affecting the catalytic activity. This review aims to describe the various alterations due to HPH treatment in enzymes, to show the influence of high-pressure on proteins and to report the HPH effects on the enzymatic activity of different enzymes employed in the food industry and research. Copyright © 2018 Elsevier Ltd. All rights reserved.

CERN's web application updates for electron and laser beam technologies

CERN Document Server

Sigas, Christos

2017-01-01

This report describes the modifications at CERN's web application for electron and laser beam technologies. There are updates at both the front and the back end of the application. New electron and laser machines were added and also old machines were updated. There is also a new feature for printing needed information.

14 CFR 151.99 - Modifications of programming standards.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Modifications of programming standards. 151... (CONTINUED) AIRPORTS FEDERAL AID TO AIRPORTS Project Programming Standards § 151.99 Modifications of programming standards. The Director, Airports, Service, or the Regional Director concerned may, on individual...

Treating Retentive Encopresis: Dietary Modification and Behavioral Techniques.

Science.gov (United States)

Nabors, Laura; Morgan, Sam B.

1995-01-01

A home-based contingency management program, consisting of diet modification, laxatives, correction for soiling accidents, stimulus control training, and positive reinforcement, was implemented for treatment of a 4-year-old encopretic male. The findings provide evidence supporting the effectiveness of dietary modification combined with behavior…

Modifications to the NRAD reactor (1977 to present)

International Nuclear Information System (INIS)

Weeks, A.A.; Pruett, D.P.; Heidel, C.C.

1986-01-01

The NRAD facility utilizes a 250-kW TRIGA reactor and is completely dedicated to neutron radiography and the development of radiography techniques. Criticality was first achieved at the NRAD reactor in October 1977. Since that time, a number of modifications have been implemented to improve operational efficiency and radiography production. The modifications to the NRAD reactor are categorized as either 'operational improvements', which have increased operational efficiency and reliability, or as 'production improvements', which have reduced the number of unscheduled shutdowns due to instrument malfunctions or mechanical failures. A brief synopsis of the significant reactor modifications in both categories is presented

POSTRANSLATIONAL MODIFICATIONS OF P53: UPSTREAM SIGNALING PATHWAYS.

Energy Technology Data Exchange (ETDEWEB)

ANDERSON,C.W.APPELLA,E.

2003-10-23

The p53 tumor suppressor is a tetrameric transcription factor that is posttranslational modified at >20 different sites by phosphorylation, acetylation, or sumoylation in response to various cellular stress conditions. Specific posttranslational modifications, or groups of modifications, that result from the activation of different stress-induced signaling pathways are thought to modulate p53 activity to regulate cell fate by inducing cell cycle arrest, apoptosis, or cellular senescence. Here we review recent progress in characterizing the upstream signaling pathways whose activation in response to various genotoxic and non-genotoxic stresses result in p53 posttranslational modifications.

A Digital Framework to Support Providers and Patients in Diabetes Related Behavior Modification.

Science.gov (United States)

Abidi, Samina; Vallis, Michael; Piccinini-Vallis, Helena; Imran, Syed Ali; Abidi, Syed Sibte Raza

2017-01-01

We present Diabetes Web-Centric Information and Support Environment (D-WISE) that features: (a) Decision support tool to assist family physicians to administer Behavior Modification (BM) strategies to patients; and (b) Patient BM application that offers BM strategies and motivational interventions to engage patients. We take a knowledge management approach, using semantic web technologies, to model the social cognition theory constructs, Canadian diabetes guidelines and BM protocols used locally, in terms of a BM ontology that drives the BM decision support to physicians and BM strategy adherence monitoring and messaging to patients. We present the qualitative analysis of D-WISE usability by both physicians and patients.

Challenges with modifications of the McClean Lake mill to process midwest ore

International Nuclear Information System (INIS)

Nguyen, T.T.; Backham, L.

2010-01-01

Midwest is a unique uranium deposit with exceptionally high arsenic content. The ore body is located 17 km west of the McClean Lake operation. The McClean Lake mill will be modified to process Midwest ore and handle solid wastes from the Midwest water treatment plant. This paper describes the modifications required of the McClean Lake mill, process challenges associated with treatment of the arsenic, and the possibility of recovering nickel and cobalt as a by-product. It also reviews the complexity in the design of the Midwest water treatment facility which incorporates reverse osmosis technology with conventional physical-chemical water treatment. (author)

ChIPnorm: a statistical method for normalizing and identifying differential regions in histone modification ChIP-seq libraries.

Science.gov (United States)

Nair, Nishanth Ulhas; Sahu, Avinash Das; Bucher, Philipp; Moret, Bernard M E

2012-01-01

The advent of high-throughput technologies such as ChIP-seq has made possible the study of histone modifications. A problem of particular interest is the identification of regions of the genome where different cell types from the same organism exhibit different patterns of histone enrichment. This problem turns out to be surprisingly difficult, even in simple pairwise comparisons, because of the significant level of noise in ChIP-seq data. In this paper we propose a two-stage statistical method, called ChIPnorm, to normalize ChIP-seq data, and to find differential regions in the genome, given two libraries of histone modifications of different cell types. We show that the ChIPnorm method removes most of the noise and bias in the data and outperforms other normalization methods. We correlate the histone marks with gene expression data and confirm that histone modifications H3K27me3 and H3K4me3 act as respectively a repressor and an activator of genes. Compared to what was previously reported in the literature, we find that a substantially higher fraction of bivalent marks in ES cells for H3K27me3 and H3K4me3 move into a K27-only state. We find that most of the promoter regions in protein-coding genes have differential histone-modification sites. The software for this work can be downloaded from http://lcbb.epfl.ch/software.html.

Functional Modification of Thioether Groups in Peptides, Polypeptides, and Proteins.

Science.gov (United States)

Deming, Timothy J

2017-03-15

Recent developments in the modification of methionine and other thioether-containing residues in peptides, polypeptides, and proteins are reviewed. Properties and potential applications of the resulting functionalized products are also discussed. While much of this work is focused on natural Met residues, modifications at other side-chain residues have also emerged as new thioether-containing amino acids have been incorporated into peptidic materials. Functional modification of thioether-containing amino acids has many advantages and is a complementary methodology to the widely utilized methods for modification at cysteine residues.

X-ray studies on piroxicam modifications

International Nuclear Information System (INIS)

Reck, G.; Bannier, G.; Hoehne, E.

1988-01-01

The anti-inflammatory drug piroxicam, 4-hydroxy-2-methyl-N-(2-pyridyl)2H-1,2-benzothiazine-3-car-boxamide-1,1-dioxide, crystallizes in three different forms, two anhydrates and one monohydrate. Crystal structure analyses of the monohydrate and one of the anhydrate were carried out by Bordner et al. and Kojic-Prodic et al., respectively. The results of the analysis of the third piroxicam modification and of an independently performed structure determination of the monohydrate are reported. Molecular structures and hydrogen bonding of all modifications are discussed. (author)

40 CFR 82.13 - Recordkeeping and reporting requirements for class I controlled substances.

Science.gov (United States)

2010-07-01

... subpart) and will not be resold or used in manufacturing. (xiii) The amount of class I, Group VI... class II controlled substances; (xii) The U.S. Customs entry form; (xiii) Dated records documenting the..., an annual list of the amount of critical use methyl bromide bought; (ii) For critical uses of class I...

Application of Atmospheric Dielectric Barrier Discharge Plasma for Polyethylene Powder Modification

International Nuclear Information System (INIS)

Pichal, J.; Aubrecht, L.; Pichal, J.; Hladik, J.; Spatenka, P.; Spatenka, P.

2006-01-01

Paper refers about a novel plasma reactor exploiting the dielectric barrier discharge (DBD) burning in air at atmospheric pressure by ambient temperature and its usability tests. Test modifications were performed with the high density polyethylene powder Borealis CB 9155-01. Modification effect was evaluated by means of dynamic capillarity rising measurements. Tests proved significant powder capillarity changes. The existence of powder surface changes was also confirmed by ESCA tests. Modification aging effect was remarkably small, hence modification effect is very time stable. In comparison with other in literature described apparatus used for this purpose the plasma reactor is of a simple construction and needs no vacuum equipment. Its operation costs are low. Described plasma modification method seems to be an appropriate method for plasma modification of polyethylene powder on the industrial scale

The effect of halloysite modification combined with in situ matrix modifications on the structure and properties of polypropylene/halloysite nanocomposites

Directory of Open Access Journals (Sweden)

V. Khunova

2013-05-01

Full Text Available The effect of various modifications/intercalations of halloysite and the combination of these modifications with in situ PP matrix modification was investigated with respect to the structure and properties of the polypropylene/halloysite nanocomposites. Hexadecyl-tri-methyl-ammonium-bromide (HEDA, 3-aminopropyltrimethoxysilane and urea were used as the intercalators/modifiers. The best intercalation was found for urea, although an unexpected insignificant impact on the mechanical properties also resulted as a consequence of the urea polarity and the significant decrease in PP crystallinity. However, the simultaneous application of 4,4!-diphenylmethylene dimaleinimide (DBMI brought about an increase in the mechanical behavior by increasing the halloysite/PP affinity as a result of in situ matrix modification. This effect was further supported by coupling between the PP and halloysite (HNT in the system containing urea-intercalated HNT. This can be explained by the occurrence of a urea-supported reaction between the imide ring of DBMI and the OH groups of the HNT, which resulted in the best mechanical behaviors achieved in this study.

Using of material-technological modelling for designing production of closed die forgings

Science.gov (United States)

Ibrahim, K.; Vorel, I.; Jeníček, Š.; Káňa, J.; Aišman, D.; Kotěšovec, V.

2017-02-01

Production of forgings is a complex and demanding process which consists of a number of forging operations and, in many cases, includes post-forge heat treatment. An optimized manufacturing line is a prerequisite for obtaining prime-quality products which in turn are essential to profitable operation of a forging company. Problems may, however, arise from modifications to the manufacturing route due to changing customer needs. As a result, the production may have to be suspended temporarily to enable changeover and optimization. Using material-technological modelling, the required modifications can be tested and optimized under laboratory conditions outside the plant without disrupting the production. Thanks to material-technological modelling, the process parameters can be varied rapidly in response to changes in market requirements. Outcomes of the modelling runs include optimum parameters for the forging part’s manufacturing route, values of mechanical properties, and results of microstructure analysis. This article describes the use of material-technological modelling for exploring the impact of the amount of deformation and the rate of cooling of a particular forged part from the finish-forging temperature on its microstructure and related mechanical properties.

Manufacturing technology of high-quality pressure castings

Directory of Open Access Journals (Sweden)

S. Pietrowski

2011-10-01

Full Text Available The paper presents manufacturing technology of pressure castings made of Al-Si alloy without porosity or with low microporosity of castings. It has been shown that the greatest impact on the porosity of the castings and the concentration of hydrogen has had the charge to the melting furnace. Liquidation or occurrence of a small microporosity of castings provides refining with solid refiners, nitrogen and modification of liquid alloy after various operations of preparing process. The liquid alloy stored in holding furnace should be refined once every 2 h with nitrogen. Authors developed a computer program of Al-Si alloys inspection with using of TDA method. The developed technology was verified under production conditions.

Structural and optical modification in 4H-SiC following 30 keV silver ion irradiation

Science.gov (United States)

Kaushik, Priya Darshni; Aziz, Anver; Siddiqui, Azher M.; Lakshmi, G. B. V. S.; Syväjärvi, Mikael; Yakimova, Rositsa; Yazdi, G. Reza

2018-05-01

The market of high power, high frequency and high temperature based electronic devices is captured by SiC due to its superior properties like high thermal conductivity and high sublimation temperature and also due to the limitation of silicon based electronics in this area. There is a need to investigate effect of ion irradiation on SiC due to its application in outer space as outer space is surrounded both by low and high energy ion irradiations. In this work, effect of low energy ion irradiation on structural and optical property of 4H-SiC is investigated. ATR-FTIR is used to study structural modification and UV-Visible spectroscopy is used to study optical modifications in 4H-SiC following 30 keV Ag ion irradiation. FTIR showed decrease in bond density of SiC along the ion path (track) due to the creation of point defects. UV-Visible absorption spectra showed decrease in optical band gap from 3.26 eV to 2.9 eV. The study showed degradation of SiC crystallity and change in optical band gap following low energy ion irradiation and should be addressed while fabricationg devices based on SiC for outer space application. Additionally, this study provides a platform for introducing structural and optical modification in 4H-SiC using ion beam technology in a controlled manner.

Enabling technologies and green processes in cyclodextrin chemistry

Directory of Open Access Journals (Sweden)

Giancarlo Cravotto

2016-02-01

Full Text Available The design of efficient synthetic green strategies for the selective modification of cyclodextrins (CDs is still a challenging task. Outstanding results have been achieved in recent years by means of so-called enabling technologies, such as microwaves, ultrasound and ball mills, that have become irreplaceable tools in the synthesis of CD derivatives. Several examples of sonochemical selective modification of native α-, β- and γ-CDs have been reported including heterogeneous phase Pd- and Cu-catalysed hydrogenations and couplings. Microwave irradiation has emerged as the technique of choice for the production of highly substituted CD derivatives, CD grafted materials and polymers. Mechanochemical methods have successfully furnished greener, solvent-free syntheses and efficient complexation, while flow microreactors may well improve the repeatability and optimization of critical synthetic protocols.

Plasma-aided surface technology for modification of materials referred to fire protection

International Nuclear Information System (INIS)

Dineff, P.; Gospodinova, D.; Kostova, L.; Vladkova, T.; Chen, E.

2008-01-01

There has been considerable interest in dielectric barrier air discharge at atmospheric pressure and room temperature over the past decade due to the increased number of industrial applications. New plasma-aided capillary impregnation technology for flame spreading stop and fire protection of porous materials was developed. Research, based on thermogravimetric analysis (TGA), differential thermal analysis (DTA), and differential scanning calorimetry (DSC), proves that plasma-chemical surface pre-treatment exert material change on chemical interaction between phosphorus containing flame retardant and wood matrix (Pinus sylvestris, Bulgaria; Pseudotsuga, Canada)

Manufacturing Technology of Composite Materials-Principles of Modification of Polymer Composite Materials Technology Based on Polytetrafluoroethylene.

Science.gov (United States)

Panda, Anton; Dyadyura, Kostiantyn; Valíček, Jan; Harničárová, Marta; Zajac, Jozef; Modrák, Vladimír; Pandová, Iveta; Vrábel, Peter; Nováková-Marcinčínová, Ema; Pavelek, Zdeněk

2017-03-31

The results of the investigations into the technological formation of new wear-resistant polymer composites based on polytetrafluoroethylene (PTFE) filled with disperse synthetic and natural compounds are presented. The efficiency of using PTFE composites reinforced with carbon fibers depends on many factors, which influence the significant improvement of physicomechanical characteristics. The results of this research allow stating that interfacial and surface phenomena of the polymer-solid interface and composition play a decisive role in PTFE composites properties. Fillers hinder the relative movement of the PTFE molecules past one another and, in this way, reduce creep or deformation of the parts, reducing the wear rate of parts used in dynamic applications as well as the coefficient of thermal expansion. The necessary structural parameters of such polymer composites are provided by regimes of process equipment.

Status of electron beam processing technology in Malaysia

International Nuclear Information System (INIS)

Ghazali, Zulkafli; Dahlan, Khairul Zaman; Aiasah, S.H.; Khomsaton, A.B.; Ting, T.M.

2003-01-01

The electron beam processing in Malaysia starting in 1991 at MINT (Malaysian Institute for Nuclear Technology Research) has been focussed on medical product sterilization, curing of surface coating and polymer modifications. Subsequent installation of accelerators by private companies promoted the development of radiation processing technologies for the use of production of heat-shrinkable products, pilot-scale flue gas purification, as well as wires, cables, tubes and hydrogels. Decomposition of a wide range of volatile organic compounds from industrial exhausts (car painting lines, volatile dioxin and furan from municipal waste incinerators) and purification of liquid wastewater and drinking water are also being under R and D work. Malaysia will continue to play an active part in the program on radiation technology to strengthen environmentally sustainable development in line with FNCA objectives. (S. Ohno)

Reproductive cloning combined with genetic modification.

Science.gov (United States)

Strong, C

2005-11-01

Although there is widespread opposition to reproductive cloning, some have argued that its use by infertile couples to have genetically related children would be ethically justifiable. Others have suggested that lesbian or gay couples might wish to use cloning to have genetically related children. Most of the main objections to human reproductive cloning are based on the child's lack of unique nuclear DNA. In the future, it may be possible safely to create children using cloning combined with genetic modifications, so that they have unique nuclear DNA. The genetic modifications could be aimed at giving such children genetic characteristics of both members of the couple concerned. Thus, cloning combined with genetic modification could be appealing to infertile, lesbian, or gay couples who seek genetically related children who have genetic characteristics of both members. In such scenarios, the various objections to human reproductive cloning that are based on the lack of genetic uniqueness would no longer be applicable. The author argues that it would be ethically justifiable for such couples to create children in this manner, assuming these techniques could be used safely.

Developments in broad-beam, ion-source technology and applications

International Nuclear Information System (INIS)

Kaufman, H.R.; Harper, J.M.E.; Cuomo, J.J.

1982-01-01

Recent advances in broad-beam, ion-source technology are summarized, including low-energy ion optics, improved extraction grid fabrication, a compact ion-source design and a gridless ion-source design. Recent applications have emphasized concepts such as stress modification of vapor deposited films, very low energy ion beams to minimize the physical sputtering portion in reactive etching, and the use of multiple sources and targets to sputter deposit alloys and compounds. A comprehensive critical review by the same authors appears concurrently, describing in detail the developments in broad-beam, ion-source technology 1 and the applications of these sources. 2

Identification of histone modifications in biomedical text for supporting epigenomic research.

Science.gov (United States)

Kolárik, Corinna; Klinger, Roman; Hofmann-Apitius, Martin

2009-01-30

Posttranslational modifications of histones influence the structure of chromatine and in such a way take part in the regulation of gene expression. Certain histone modification patterns, distributed over the genome, are connected to cell as well as tissue differentiation and to the adaption of organisms to their environment. Abnormal changes instead influence the development of disease states like cancer. The regulation mechanisms for modifying histones and its functionalities are the subject of epigenomics investigation and are still not completely understood. Text provides a rich resource of knowledge on epigenomics and modifications of histones in particular. It contains information about experimental studies, the conditions used, and results. To our knowledge, no approach has been published so far for identifying histone modifications in text. We have developed an approach for identifying histone modifications in biomedical literature with Conditional Random Fields (CRF) and for resolving the recognized histone modification term variants by term standardization. For the term identification F1 measures of 0.84 by 10-fold cross-validation on the training corpus and 0.81 on an independent test corpus have been obtained. The standardization enabled the correct transformation of 96% of the terms from training and 98% from test the corpus. Due to the lack of terminologies exhaustively covering specific histone modification types, we developed a histone modification term hierarchy for use in a semantic text retrieval system. The developed approach highly improves the retrieval of articles describing histone modifications. Since text contains context information about performed studies and experiments, the identification of histone modifications is the basis for supporting literature-based knowledge discovery and hypothesis generation to accelerate epigenomic research.

Microscale surface modifications for heat transfer enhancement.

Science.gov (United States)

Bostanci, Huseyin; Singh, Virendra; Kizito, John P; Rini, Daniel P; Seal, Sudipta; Chow, Louis C

2013-10-09

In this experimental study, two surface modification techniques were investigated for their effect on heat transfer enhancement. One of the methods employed the particle (grit) blasting to create microscale indentations, while the other used plasma spray coating to create microscale protrusions on Al 6061 (aluminum alloy 6061) samples. The test surfaces were characterized using scanning electron microscopy (SEM) and confocal scanning laser microscopy. Because of the surface modifications, the actual surface area was increased up to 2.8× compared to the projected base area, and the arithmetic mean roughness value (Ra) was determined to vary from 0.3 μm for the reference smooth surface to 19.5 μm for the modified surfaces. Selected samples with modified surfaces along with the reference smooth surface were then evaluated for their heat transfer performance in spray cooling tests. The cooling system had vapor-atomizing nozzles and used anhydrous ammonia as the coolant in order to achieve heat fluxes up to 500 W/cm(2) representing a thermal management setting for high power systems. Experimental results showed that the microscale surface modifications enhanced heat transfer coefficients up to 76% at 500 W/cm(2) compared to the smooth surface and demonstrated the benefits of these practical surface modification techniques to enhance two-phase heat transfer process.

Surface Modification of Ceramic Membranes with Thin-film Deposition Methods for Wastewater Treatment

KAUST Repository

Jahangir, Daniyal

2017-12-01

Membrane fouling, which is caused by deposition/adsorption of foulants on the surface or within membrane pores, still remains a bottleneck that hampers the widespread application of membrane bioreactor (MBR) technology for wastewater treatment. Recently membrane surface modification has proved to be a useful method in water/wastewater treatment to improve the surface hydrophilicity of membranes to obtain higher water fluxes and to reduce fouling. In this study, membrane modification was investigated by depositing a thin film of same thickness of TiO2 on the surface of an ultrafiltration alumina membrane. Various thin-film deposition (TFD) methods were employed, i.e. electron-beam evaporation, sputter and atomic layer deposition (ALD), and a comparative study of the methods was conducted to assess fouling inhibition performance in a lab-scale anaerobic MBR (AnMBR) fed with synthetic municipal wastewater. Thorough surface characterization of all modified membranes was carried out along with clean water permeability (CWP) tests and fouling behavior by bovine serum albumin (BSA) adsorption tests. The study showed better fouling inhibition performance of all modified membranes; however the effect varied due to different surface characteristics obtained by different deposition methods. As a result, ALD-modified membrane showed a superior status in terms of surface characteristics and fouling inhibition performance in AnMBR filtration tests. Hence ALD was determined to be the best TFD method for alumina membrane surface modification for this study. ALD-modified membranes were further characterized to determine an optimum thickness of TiO2-film by applying different ALD cycles. ALD treatment significantly improved the surface hydrophilicity of the unmodified membrane. Also ALD-TiO2 modification was observed to reduce the surface roughness of original alumina membrane, which in turn enhanced the anti-fouling properties of modified membranes. Finally, a same thickness of ALD

Decoding ClassDojo: Psycho-Policy, Social-Emotional Learning and Persuasive Educational Technologies

Science.gov (United States)

Williamson, Ben

2017-01-01

ClassDojo is one of the world's most successful educational technologies, currently used by over 3 million teachers and 35 million children globally. It reinforces and enacts emerging governmental "psycho-policies" around the measurement and modification of children's social and emotional learning in schools. This article focuses…

Safety in the Utilization and Modification of Research Reactors. Specific Safety Guide

Energy Technology Data Exchange (ETDEWEB)

NONE

2012-07-15

This Safety Guide is a revision of Safety Series No. 35-G2 on safety in the utilization and modification of research reactors. It provides recommendations on meeting the requirements for the categorization, safety assessment and approval of research reactor experiments and modification projects. Specific safety considerations in different phases of utilization and modification projects are covered, including the pre-implementation, implementation and post-implementation phases. Guidance is also provided on the operational safety of experiments, including in the handling, dismantling, post-irradiation examination and disposal of experimental devices. Examples of the application of the safety categorization process for experiments and modification projects and of the content of the safety analysis report for an experiment are also provided. Contents: 1. Introduction; 2. Management system for the utilization and modification of a research reactor; 3. Categorization, safety assessment and approval of an experiment or modification; 4. Safety considerations for the design of an experiment or modification; 5. Pre-implementation phase of a modification or utilization project; 6. Implementation phase of a modification or utilization project; 7. Post-implementation phase of a utilization or modification project; 8. Operational safety of experiments at a research reactor; 9. Safety considerations in the handling, dismantling, post-irradiation examination and disposal of experimental devices; 10. Safety aspects of out-of-reactor-core installations; Annex I: Example of a checklist for the categorization of an experiment or modification at a research reactor; Annex II: Example of the content of the safety analysis report for an experiment at a research reactor; Annex III: Examples of reasons for a modification at a research reactor.

Safety in the Utilization and Modification of Research Reactors. Specific Safety Guide

International Nuclear Information System (INIS)

2012-01-01

This Safety Guide is a revision of Safety Series No. 35-G2 on safety in the utilization and modification of research reactors. It provides recommendations on meeting the requirements for the categorization, safety assessment and approval of research reactor experiments and modification projects. Specific safety considerations in different phases of utilization and modification projects are covered, including the pre-implementation, implementation and post-implementation phases. Guidance is also provided on the operational safety of experiments, including in the handling, dismantling, post-irradiation examination and disposal of experimental devices. Examples of the application of the safety categorization process for experiments and modification projects and of the content of the safety analysis report for an experiment are also provided. Contents: 1. Introduction; 2. Management system for the utilization and modification of a research reactor; 3. Categorization, safety assessment and approval of an experiment or modification; 4. Safety considerations for the design of an experiment or modification; 5. Pre-implementation phase of a modification or utilization project; 6. Implementation phase of a modification or utilization project; 7. Post-implementation phase of a utilization or modification project; 8. Operational safety of experiments at a research reactor; 9. Safety considerations in the handling, dismantling, post-irradiation examination and disposal of experimental devices; 10. Safety aspects of out-of-reactor-core installations; Annex I: Example of a checklist for the categorization of an experiment or modification at a research reactor; Annex II: Example of the content of the safety analysis report for an experiment at a research reactor; Annex III: Examples of reasons for a modification at a research reactor.

Industrial assessment of nonbackfittable PWR design modifications. Final report

International Nuclear Information System (INIS)

Matzie, R.A.; Daleas, R.S.; Miller, D.D.

1980-11-01

As part of the US Department of Energy's Advanced Reactor Design Study, various nonbackfittable PWR design modifications were evaluated to determine their potential for improved uranium utilization and commercial viability. Combustion Engineering, Inc. contributed to this effort through participation in the Battelle Pacific Northwest Laboratory industrial assessment of such design modifications. Seven modifications, including the use of higher primary system temperatures and pressures, rapid-frequent refueling, end-of-cycle stretchout, core periphery modifications, radial blankets, low power density cores, and small PWR assemblies, were evaluated with respect to uranium utilization, economics, technical and operational complexity, and several other subjective considerations. Rapid-frequent refueling was judged to have the highest potential although it would probably not be economical for the majority of reactors with the design assumptions used in this assessment

How genetic modification of roots affects rhizosphere processes and plant performance

NARCIS (Netherlands)

Kabouw, P.; Van Dam, N.M.; Van der Putten, W.H.; Biere, A.

2012-01-01

Genetic modification of plants has become common practice. However, root-specific genetic modifications have only recently been advocated. Here, a review is presented regarding how root-specific modifications can have both plant internal and rhizosphere-mediated effects on aboveground plant

ZT-40M system design, modification, and installation

International Nuclear Information System (INIS)

Hammer, C.F.

1981-01-01

ZT-40 is a reversed field pinch experiment which had been operated as originally designed, with a ceramic discharge tube until November 1980. At that time, the experiment was shut down for major modifications. This paper will describe these modifications in general and discuss in detail the design of the energy system

21 CFR 640.74 - Modification of Source Plasma.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Modification of Source Plasma. 640.74 Section 640...) BIOLOGICS ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Source Plasma § 640.74 Modification of Source Plasma. (a) Upon approval by the Director, Center for Biologics Evaluation and Research, Food and...

Status of Technological Advancements for Reducing Aircraft Gas Turbine Engine Pollutant Emissions

Science.gov (United States)

Rudey, R. A.

1975-01-01

Combustor test rig results indicate that substantial reductions from current emission levels of carbon monoxide (CO), total unburned hydrocarbons (THC), oxides of nitrogen (NOx), and smoke are achievable by employing varying degrees of technological advancements in combustion systems. Minor to moderate modifications to existing conventional combustors produced significant reductions in CO and THC emissions at engine low power (idle/taxi) operating conditions but did not effectively reduce NOx at engine full power (takeoff) operating conditions. Staged combusiton techniques were needed to simultaneously reduce the levels of all the emissions over the entire engine operating range (from idle to takeoff). Emission levels that approached or were below the requirements of the 1979 EPA standards were achieved with the staged combustion systems and in some cases with the minor to moderate modifications to existing conventional combustion systems. Results from research programs indicate that an entire new generation of combustor technology with extremely low emission levels may be possible in the future.

30 CFR 18.81 - Field modification of approved (permissible) equipment; application for approval of modification...

Science.gov (United States)

2010-07-01

... TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES... having jurisdiction at the mine where such equipment is to be operated stating the modifications which...

EG and G electron linac modifications

International Nuclear Information System (INIS)

Norris, N.J.; Detch, J.L.; Kocimski, S.M.; Sawyer, C.R.; Hudson, C.L.

1986-01-01

The electron linear accelerator at EG and G/EM, Santa Barbara Operations, installed in 1963, has been subsequently modified to produce short, intense beam pulses used in the test, calibration and development of many types of fast radiation detectors and systems. The first practical use of the single RF pulse operation, now used in many accelerators, was demonstrated on this accelerator in the late 60s. A major three-year modification, to replace obsolete equipment and bring all the subsystems up to the current state of the art, has increased the beam intensity, stability and reliability. These modifications are discussed

GENDER SPECIFICS OF USING DIGITAL TECHNOLOGIES BY CHILDREN

OpenAIRE

Gulshat Firazovna Shakirova*

2018-01-01

In this paper, the gender characteristics of children of preschool age that are actively using digital technologies in everyday life are studied, the age characteristics of children are described, and the terminology of the research is defined. The study used psychological methods: questionnaire, observation of children of preschool age on the basis of the questionnaire "Masculinity, femininity and gender personality type" (a modification of O. G. Lopukhova), the conversation "Boys and ...

Fundamentos históricos e teóricos da noção de soberania: a contribuição dos "Papas juristas" do século XIII

Directory of Open Access Journals (Sweden)

Raquel Kritsch

2010-12-01

Full Text Available O objetivo deste artigo é discutir a contribuição do pensamento eclesiástico medieval tardio para a formação do conceito de soberania. Como o Estado moderno, tal conceito tem uma gênese demorada: é parte de um processo de transformação jurídica e política, do qual resulta um novo mapeamento do poder e das lealdades na Europa. A conformação desse novo sistema de poder tem como contrapartida a constituição de uma nova ordem jurídica. Essa ordem redefine os vínculos de comando e obediência, constituindo unida des políticas como áreas de jurisdição exclusiva e estabelecendo, entre essas unidades, relações de igualdade: nenhuma se reconhece como subordinada a outra. Todas essas questões podem ser entendidas como disputas de jurisdição. Trata-se de saber quem julga e quem pune delitos civis ou violações de normas religiosas. Os poderes de legislar, de mudar a lei, de resolver como últi ma instância e de controlar o uso da violência constituem o que os autores modernos nomearam soberania. Apontar a contribuição dos chamados Papas juristas do século XIII para a formulação de alguns elementos centrais a esta definição é a tarefa a ser leva da a cabo neste estudo.

Manufacturing Technology of Composite Materials—Principles of Modification of Polymer Composite Materials Technology Based on Polytetrafluoroethylene

Directory of Open Access Journals (Sweden)

Anton Panda

2017-03-01

Full Text Available The results of the investigations into the technological formation of new wear-resistant polymer composites based on polytetrafluoroethylene (PTFE filled with disperse synthetic and natural compounds are presented. The efficiency of using PTFE composites reinforced with carbon fibers depends on many factors, which influence the significant improvement of physicomechanical characteristics. The results of this research allow stating that interfacial and surface phenomena of the polymer–solid interface and composition play a decisive role in PTFE composites properties. Fillers hinder the relative movement of the PTFE molecules past one another and, in this way, reduce creep or deformation of the parts, reducing the wear rate of parts used in dynamic applications as well as the coefficient of thermal expansion. The necessary structural parameters of such polymer composites are provided by regimes of process equipment.

Evaluation of proposed panel closure modifications at WIPP

Energy Technology Data Exchange (ETDEWEB)

Allen, Lawrence E.; Silva, Matthew K.; Channell, James K.; Abel, John F.; Morgan, Dudley R.

2001-12-31

A key component in the design of the WIPP repository is the installation of concrete structures as panel seals in the intake and exhaust drifts after a panel has been filled with waste containers. As noted in the EPA final rule, the panel seal closure system is intended to block brine flow between the waste panels at the WIPP. On April 17, 2001, the DOE proposed seven modifications to the EPA concerning the design of the panel closure system. EPA approval of these modifications is necessary since the details of the panel design are specified in EPA’s final rule as a condition for WIPP certification. However, the EPA has not determined whether a rulemaking would be required for these proposed design modifications. On September 4, 2001, the DOE withdrew the request, noting that it would be resubmitted on a future date. The Environmental Evaluation Group (EEG) contracted with two engineers, Dr. John Abel and Dr. Rusty Morgan, to evaluate the proposed modifications. The EEG has accepted the conclusions and recommendations from these two experts: 1) replacement of Salado Mass Concrete with a generic salt-based concrete; 2) replacement of the explosion wall with a construction wall; 3) replacement of freshwater grouting with salt-based grouting; 4) option to allow surface or underground mixing; and 5) option to allow up to one year for completion of closure. The proposed modification to allow local carbonate river rock as aggregate is acceptable pending demonstration that no problems will exist in the resulting concrete. The proposed modification to give the contractor discretion in removal of steel forms is not supported. Instead, several recommendations are made to specifically reduce the number of forms left, thereby reducing potential migration pathways.

Modification of Particle Distributions by MHD Instabilities II

International Nuclear Information System (INIS)

White, Roscoe B.

2011-01-01

The modification of particle distributions by low amplitude magnetohydrodynamic modes is an important topic for magnetically confined plasmas. Low amplitude modes are known to be capable of producing significant modification of injected neutral beam profiles, and the same can be expected in burning plasmas for the alpha particle distributions. Flattening of a distribution in an island due to phase mixing and portions of phase space becoming stochastic lead to modification of the particle distribution, a process extremely rapid in the time scale of an experiment but still very long compared to the time scale of guiding center simulations. Large amplitude modes can cause profile avalanche and particle loss. Thus it is very valuable to be able to predict the temporal evolution of a particle distribution produced by a given spectrum of magnetohydrodynamic modes. In this paper we further develop and investigate the use of a new method of determining domains of phase space in which good KAM surfaces do not exist and use this method to examine a well documented case of profile modification by instabilities.

3. International Symposium 'Vacuum Technology and Equipment'. ISVTE-3; 3. Mezhdunarodnyj Simpozium 'Vakuumnye tekhnologii i oborudovanie'. ISVTE-3

Energy Technology Data Exchange (ETDEWEB)

Kogan, V S; Shulaev, V M [eds.

1999-07-01

The reports of the 3th International Symposium 'Vacuum Technology and Equipment', which was held in Kharkov at 22-24 September 1999 are presented. In this issue such subject are published: equipment and technology for thin and coating preparation. Studies of their surface layer and material modification by corpuscular effect and light.

Multi-Chromatic Ultrashort Pulse Filamentation and Bulk Modification in Dielectrics

Science.gov (United States)

2016-05-05

AFRL-AFOSR-VA-TR-2016-0194 Multi- Chromatic Ultrashort Pulse Filamentation and Bulk Modification in Dielectrics Jeremy Gulley KENNESAW STATE...Jan 2016 4. TITLE AND SUBTITLE Multi- chromatic Ultrashort Pulse Filamentation and Bulk Modification in Dielectrics 5a. CONTRACT NUMBER 5b. GRANT...in, and modification of, dielectric solids by multi- chromatic ultrashort laser pulses. It was a theoretical effort to develop models of multi

Global study of nuclear modifications on parton distribution functions

Directory of Open Access Journals (Sweden)

Rong Wang

2017-07-01

Full Text Available A global analysis of nuclear medium modifications of parton distributions is presented using deeply inelastic scattering data of various nuclear targets. Two obtained data sets are provided for quark and gluon nuclear modification factors, referred as nIMParton16. One is from the global fit only to the experimental data of isospin-scalar nuclei (Set A, and the other is from the fit to all the measured nuclear data (Set B. The scale-dependence is described by DGLAP equations with nonlinear corrections in this work. The Fermi motion and off-shell effect, nucleon swelling, and parton–parton recombination are taken into account together for modeling the complicated x-dependence of nuclear modification. The nuclear gluon shadowing in this paper is dynamically generated by the QCD evolution of parton splitting and recombination processes with zero gluon density at the input scale. Sophisticated nuclear dependence of nuclear medium effects is studied with only two free parameters. With the obtained free parameters from the global analysis, the nuclear modifications of parton distribution functions of unmeasured nuclei can be predicted in our model. Nuclear modification of deuteron is also predicted and shown with recent measurement at JLab.

Study on Welding Mechanism Based on Modification of Polypropylene for Improving the Laser Transmission Weldability to PA66

Science.gov (United States)

Liu, Huixia; Jiang, Hairong; Guo, Dehui; Chen, Guochun; Yan, Zhang; Li, Pin; Zhu, Hejun; Chen, Jun; Wang, Xiao

2015-01-01

Polypropylene and PA66 are widely used in our daily life, but they cannot be welded by laser transmission welding (LTW) because of polar differences and poor compatibility. In this paper, grafting modification technology is used to improve the welding performance between polypropylene and PA66. Firstly, the strong reactive and polar maleic-anhydride (MAH) is grafted to polypropylene and infrared spectrometer is used to prove that MAH has been grafted to polypropylene. At the same time, the mechanical and thermal properties of the graft modified polypropylene (TGMPP) are tested. The results prove that the grafting modification has little influence on them. Also, the optical properties of TGMPP are measured. Then, the high welding strength between TGMPP and PA66 is found and the mechanism of the weldability is researched, which shows that there are two reasons for the high welding strength. By observing the micro morphology of the welding zone, one reason found is that the modification of polypropylene can improve the compatibility between polypropylene and PA66 and make them easy to diffuse mutually, which causes many locking structures formed in the welding region. The other reason is that there are chemical reactions between TGMPP and PA66 proved by the X-ray photoelectron spectrometer. PMID:28793484

Detection of Genetic Modification 'ac2' in Potato Foodstuffs

Directory of Open Access Journals (Sweden)

Petr Kralik

2009-01-01

Full Text Available The genetic modification 'ac2' is based on the insertion and expression of ac2 gene, originally found in seeds of amaranth (Amaranthus caudatus, into the genome of potatoes (Solanum tuberosum. The purpose of the present study is to develop a PCR method for the detection of the mentioned genetically modified potatoes in various foodstuffs. The method was used to test twenty different potato-based products; none of them was positive for the genetic modification 'ac2'. The European Union legislation requires labelling of products made of or containing more than 0.9 % of genetically modified organisms. The genetic modification 'ac2' is not allowed on the European Union market. For that reason it is suitable to have detection methods, not only for the approved genetic modifications, but also for the 'unknown' ones, which could still occur in foodstuffs.

SIZE REDUCTION OF ELECTROSTATIC PRECIPITATOR CHAMBER BY MODIFICATION OF GAS FLOW DISTRIBUTION

Directory of Open Access Journals (Sweden)

Beata Sładkowska-Rybka

2014-10-01

Full Text Available Electrostatic precipitators (ESP are one of the most effective devices for particulate emission control, removing from the exhaust gases even 99,9 % of dust particles. The collection efficiency of the ESP depends on a number of factors: mechanical design and electrical operating parameters, physical and chemical properties of cleaned gas, characteristic of dust particles suspended in the gas. Among the most important factors affecting the ESP effectiveness, the velocity and the distribution of gas flow in the ESP chamber should be also indicated. Significant increase in ESP efficiency is possible thanks to the application of Skewed Gas Flow Technology (SGFT. In this paper the computer simulations results are shown. Authors investigated the possibility of ESP chamber size reduction by modification of gas flow distribution.

Lost in Translation: Defects in Transfer RNA Modifications and Neurological Disorders

Directory of Open Access Journals (Sweden)

Andrea Bednářová

2017-05-01

Full Text Available Transfer RNAs (tRNAs are key molecules participating in protein synthesis. To augment their functionality they undergo extensive post-transcriptional modifications and, as such, are subject to regulation at multiple levels including transcription, transcript processing, localization and ribonucleoside base modification. Post-transcriptional enzyme-catalyzed modification of tRNA occurs at a number of base and sugar positions and influences specific anticodon–codon interactions and regulates translation, its efficiency and fidelity. This phenomenon of nucleoside modification is most remarkable and results in a rich structural diversity of tRNA of which over 100 modified nucleosides have been characterized. Most often these hypermodified nucleosides are found in the wobble position of tRNAs, where they play a direct role in codon recognition as well as in maintaining translational efficiency and fidelity, etc. Several recent studies have pointed to a link between defects in tRNA modifications and human diseases including neurological disorders. Therefore, defects in tRNA modifications in humans need intensive characterization at the enzymatic and mechanistic level in order to pave the way to understand how lack of such modifications are associated with neurological disorders with the ultimate goal of gaining insights into therapeutic interventions.

Proposed Modification of the Progressive Retirement Programme

CERN Document Server

2003-01-01

After discussion at TREF on 29 October 2003, the Management proposes in this document a modification affecting one of the general principles of the Progressive Retirement Programme (PRP), decided by the Council in December 1996 and introduced in April 1997. This modification would authorise the Director-General, in exceptional cases, as indicated in section 3 below, and, with the staff member's consent, to cancel his or her participation in the PRP and to reinstate the staff member in his or her original contractual situation. No modifications to the Staff Rules and Regulations are required. The proposal set out in section 3 of the present document is submitted by the Management, after consultation of the Governing Board of the Pension Fund, for recommendation by the Finance Committee to the Council and for approval by the Council, to enter into force as of 1 January 2004.

La expansión del posesivo pospuesto a la luz de documentación navarra (y aragonesa del siglo XIII

Directory of Open Access Journals (Sweden)

Ángeles Romero Cambrón

2016-06-01

Full Text Available En los primitivos documentos romances el posesivo sólo aparece antepuesto al sustantivo (“(el nuestro padre”. La posposición (“padre nuestro” se empieza a registrar en el siglo XIII en aragonés y en dialecto navarro. Considerando principalmente la documentación de esta segunda variedad, el presente trabajo tiene como objetivo determinar el modo en que el posesivo adquirió la capacidad de aparecer pospuesto. Este cambio se vio impulsado por factores de naturaleza estructural. Uno de ellos es la existencia de la construcción posesiva con de y pronombre personal (“por raçón de mí”; otro, la concurrencia del posesivo en coordinación, bien con el sintagma preposicional (“nin subdito vuestro nin de la eglesia”, bien con otro posesivo (“l’amor nuestra e vuestra”. El posesivo se pospondría adoptando la posición propia del sintagma preposicional. Asimismo, habría influido en la imposición del cambio la tendencia a aligerar la posición prenominal cuando concurrían en ella más de un adyacente. In the first Romance texts, possessives only occur in prenominal position (e.g. (el nuestro padre. The earliest records of postposition (e.g. padre nuestro date back to the 13th century in Aragonese and in Navarrese dialect. This paper reports largely on documentation involving Navarrese in order to determine in what way the postpositive placement of the possessive became normal. The influence of three grammar structures has been found to trigger possessive postposition. The first structure is a possessive construction consisting of the preposition de followed by a personal pronoun (e.g. campo de nos. The second structure includes a possessive in coordination either with a prepositional phrase (nin subdito vuestro nin de la eglesia or with another possessive (l’amor nuestra e vuestra. In this case, the possessive occurs after the noun in the natural place of a prepositional phrase. Finally, possessive postposition became a

Exploring memory hierarchy design with emerging memory technologies

CERN Document Server

Sun, Guangyu

2014-01-01

This book equips readers with tools for computer architecture of high performance, low power, and high reliability memory hierarchy in computer systems based on emerging memory technologies, such as STTRAM, PCM, FBDRAM, etc.  The techniques described offer advantages of high density, near-zero static power, and immunity to soft errors, which have the potential of overcoming the “memory wall.”  The authors discuss memory design from various perspectives: emerging memory technologies are employed in the memory hierarchy with novel architecture modification;  hybrid memory structure is introduced to leverage advantages from multiple memory technologies; an analytical model named “Moguls” is introduced to explore quantitatively the optimization design of a memory hierarchy; finally, the vulnerability of the CMPs to radiation-based soft errors is improved by replacing different levels of on-chip memory with STT-RAMs.   ·         Provides a holistic study of using emerging memory technologies i...

Exploring oxidative modifications of tyrosine

DEFF Research Database (Denmark)

Houée-Lévin, C; Bobrowski, K; Horakova, L

2015-01-01

residues are oxidised in vivo with impact on cellular homeostasis and redox signalling pathways. A notable example is tyrosine, which can undergo a number of oxidative post-translational modifications to form 3-hydroxy-tyrosine, tyrosine crosslinks, 3-nitrotyrosine and halogenated tyrosine, with different...... effects on cellular functions. Tyrosine oxidation has been studied extensively in vitro, and this has generated detailed information about the molecular mechanisms that may occur in vivo. An important aspect of studying tyrosine oxidation both in vitro and in biological systems is the ability to monitor...... residues modified and the nature of the modification. These approaches have helped understanding of the consequences of tyrosine oxidation in biological systems, especially its effects on cell signalling and cell dysfunction, linking to roles in disease. There is mounting evidence that tyrosine oxidation...

Progress in the molecular and genetic modification breeding of beef cattle in China.

Science.gov (United States)

Tong, Bin; Zhang, Li; Li, Guang-Peng

2017-11-20

The studies of beef cattle breeding in China have been greatly improved with the rapid development of the international beef cattle industrialization. The beef cattle breeding technologies have rapidly transformed from traditional breeding to molecular marker-assisted breeding, genomic selection and genetic modification breeding. Hundreds of candidate genes and molecular markers associated with growth, meat quality, reproduction performance and diseases resistance have been identified, and some of them have already been used in cattle breeding. Genes and molecular markers associated with growth and development are focused on the growth hormone, muscle regulatory factors, myostatin and insulin-like growth factors. Meat quality is mediated by fatty acid transport and deposition related signals, calpains and calpain system, muscle regulatory factors and muscle growth regulation pathways. Reproduction performance is regulated by GnRH-FSH-LH, growth differentiation factor 9, prolactin receptor and forkhead box protein O1. Disease resistance is modulated by the major histocompatibility complex gene family, toll-like receptors, mannose-binding lectin and interferon gene signals. In this review, we summarize the most recent progress in beef cattle breeding in marker-assisted selection, genome-wide selection and genetic modification breeding, aiming to provide a reference for further genetic breeding research of beef cattle in China.

Functional Modification of Thioether Groups in Peptides, Polypeptides, and Proteins

OpenAIRE

Deming, TJ

2017-01-01

Recent developments in the modification of methionine and other thioether-containing residues in peptides, polypeptides, and proteins are reviewed. Properties and potential applications of the resulting functionalized products are also discussed. While much of this work is focused on natural Met residues, modifications at other side-chain residues have also emerged as new thioether-containing amino acids have been incorporated into peptidic materials. Functional modification of thioether-cont...

Concerning safety issue associated with approval of modification of plan for reprocessing facilities of Power Reactor and Nuclear Fuel Development Corporation (reply to inquiry)

Energy Technology Data Exchange (ETDEWEB)

1989-01-01

In response to an inquiry on the title issue received on Sept. 16, 1988, the Nuclear Safety Commission made an adequate study and submitted the findings to the Prime Minister on Oct. 20. the relevant modifications include the installation of combustion facilities comprising two furnaces to replace the existing facilities, and the addition of uranyl nitrate solution receiving equipment to the existing facilities for plutonium conversion technology development. The study addressed the effect of the modifications on the safety of the facilities and the environment. The combustion facilities, equipment and underground seepage water tank are designed in accordance with the applicable anti-earthquake standards. The facilities will be constructed of incombustible of flame-retardant materials. Equipment in the facilities will be used under negative pressure to prevent counterflow. Adequate measures will be taken for shielding, exposure control, waste disposal, etc. It is concluded that the modifications will not affect the safety of the reprocessing facilities. (Nogami, K.).

Concerning safety issue associated with approval of modification of plan for reprocessing facilities of Power Reactor and Nuclear Fuel Development Corporation (reply to inquiry)

International Nuclear Information System (INIS)

1989-01-01

In response to an inquiry on the title issue received on Sept. 16, 1988, the Nuclear Safety Commission made an adequate study and submitted the findings to the Prime Minister on Oct. 20. the relevant modifications include the installation of combustion facilities comprising two furnaces to replace the existing facilities, and the addition of uranyl nitrate solution receiving equipment to the existing facilities for plutonium conversion technology development. The study addressed the effect of the modifications on the safety of the facilities and the environment. The combustion facilities, equipment and underground seepage water tank are designed in accordance with the applicable anti-earthquake standards. The facilities will be constructed of incombustible of flame-retardant materials. Equipment in the facilities will be used under negative pressure to prevent counterflow. Adequate measures will be taken for shielding, exposure control, waste disposal, etc. It is concluded that the modifications will not affect the safety of the reprocessing facilities. (Nogami, K.)

Cavitation dispersion of carbon nanotubes and modification of cement systems

Directory of Open Access Journals (Sweden)

GUSEV Boris Vladimirovich

2014-12-01

Full Text Available The most common research areas in construction material science deals with the development of new efficient methods to increase strength properties of materials. One of such methods is modification of composite matrices with carbon nanotubes. The characteristics of nanomodified concretes to a great extent depend on selected method of introduction of carbon nanotubes into material. The predispersion of CNT in mixing water with plasticizing additive through ultrasound impact on the environment with colloid and other types of particles including nanoparticles is the most frequently used scientific method which provides even distribution of nanoparticles in cement. In some works the separation of agglomerated CNT in suspension was conducted by means of ultrasound treatment. The further analysis showed that the main drawbacks of ultrasound dispersion are high energy output and low performance. That causes inconvenience for application of them in manufacturing process. The methods of cavitation dispersion which were developed in the late 90ies in the XXI century today are becoming commonly used in practice. The work presents the results of dispersion of multi-layer nanotubes performed on the hydrodynamic cavitation equipment. It was determined that the use of such equipment makes it possible to produce stable and even carbon dispersions and to introduce and distribute them uniformly in concrete in the same way as in the case when ultrasound treatment is performed. The advantages of this technology are considerable decrease of energy consumption and possibility to treat enormous amounts of liquids which are necessary for modification of concrete in real production process.

Selected properties of laser cladding coatings shaped using Flow drill technology

Directory of Open Access Journals (Sweden)

Bartkowski Dariusz

2017-01-01

Full Text Available The paper presents the investigations of selected chemical and mechanical properties as well as macro- and microstructure of materials formed using thermal drilling process (Flow drill. The aim of this study was to determine the microstructure of the coatings produced using laser cladding with powder technology. The coatings were produced on the low-carbon steel using 1 kW disc laser. After modification of surface, the thermal drilling process was applied. To produce all coatings, the pure copper powder was used. In this study the laser power equal of 500, 700 and 900 W were used. The microstructure, chemical composition (EDS and microhardness were investigation. It was found that the surface modification of low carbon steel and next conducted thermal drilling process caused change the surface properties on the hole flange. It was found that surface modification of steel using laser cladding with cooper powder and next Flow drill process contributes to the change in microhardness and chemical composition on hole flange.

On P values and effect modification.

Science.gov (United States)

Mayer, Martin

2017-12-01

A crucial element of evidence-based healthcare is the sound understanding and use of statistics. As part of instilling sound statistical knowledge and practice, it seems useful to highlight instances of unsound statistical reasoning or practice, not merely in captious or vitriolic spirit, but rather, to use such error as a springboard for edification by giving tangibility to the concepts at hand and highlighting the importance of avoiding such error. This article aims to provide an instructive overview of two key statistical concepts: effect modification and P values. A recent article published in the Journal of the American College of Cardiology on side effects related to statin therapy offers a notable example of errors in understanding effect modification and P values, and although not so critical as to entirely invalidate the article, the errors still demand considerable scrutiny and correction. In doing so, this article serves as an instructive overview of the statistical concepts of effect modification and P values. Judicious handling of statistics is imperative to avoid muddying their utility. This article contributes to the body of literature aiming to improve the use of statistics, which in turn will help facilitate evidence appraisal, synthesis, translation, and application.

Treatment plan modification using voxel-based weighting factors/dose prescription

International Nuclear Information System (INIS)

Wu Chuan; Olivera, Gustavo H; Jeraj, Robert; Keller, Harry; Mackie, Thomas R

2003-01-01

Under various clinical situations, it is desirable to modify the original treatment plan to better suit the clinical goals. In this work, a method to help physicians modify treatment plans based on their clinical preferences is proposed. The method uses a weighted quadratic dose objective function. The commonly used organ-/ROI-based weighting factors are expanded to a set of voxel-based weighting factors in order to obtain greater flexibility in treatment plan modification. Two different but equivalent modification schemes based on Rustem's quadratic programming algorithms -modification of a weighting matrix and modification of prescribed doses - are presented. Case studies demonstrated the effectiveness of the two methods with regard to their capability to fine-tune treatment plans

Stability studies of plasma modification effects of polylactide and polycaprolactone surface layers

Energy Technology Data Exchange (ETDEWEB)

Moraczewski, Krzysztof, E-mail: kmm@ukw.edu.pl [Kazimierz Wielki University, Chodkiewicza 30, 85-064 Bydgoszcz (Poland); Stepczyńska, Magdalena [Kazimierz Wielki University, Chodkiewicza 30, 85-064 Bydgoszcz (Poland); Malinowski, Rafał [Institute for Engineering of Polymer Materials and Dyes, Marii Skłodowskiej-Curie 55, 87‐100 Toruń (Poland); Rytlewski, Piotr; Jagodziński, Bartłomiej; Żenkiewicz, Marian [Kazimierz Wielki University, Chodkiewicza 30, 85-064 Bydgoszcz (Poland)

2016-07-30

Highlights: • Plasma modification affects surface roughness, wettability and surface energy. • Polylactide and polycaprolactone aging causes decay of the modification effects. • Changes in the surface characteristic and wettability deterioration were observed. • The decay occurs due to migration of low molecular weight molecules to the surface. • Plasma modification effect lasts longer in the case of polycaprolactone. - Abstract: The article presents results of research on the stability of oxygen plasma modification effects of polylactide and polycaprolactone surface layers. The modified samples were aged for three, six or nine weeks. The studies were carried out using scanning electron microscopy, goniometry and Fourier transform infrared spectroscopy. Studies have shown that the plasma modification has significant impact on the geometric structure and chemical composition of the surface, wettability and surface energy of tested polymers. The modification effects are not permanent. It has been observed that over time the effects of plasma modification fade. Studies have shown that modifying effect lasts longer in the case of polycaprolactone.

Chromatin proteins and modifications as drug targets

DEFF Research Database (Denmark)

Helin, Kristian; Dhanak, Dashyant

2013-01-01

A plethora of groundbreaking studies have demonstrated the importance of chromatin-associated proteins and post-translational modifications of histones, proteins and DNA (so-called epigenetic modifications) for transcriptional control and normal development. Disruption of epigenetic control...... is a frequent event in disease, and the first epigenetic-based therapies for cancer treatment have been approved. A generation of new classes of potent and specific inhibitors for several chromatin-associated proteins have shown promise in preclinical trials. Although the biology of epigenetic regulation...

Intracranial Hemorrhage: A Devastating Outcome of Congenital Bleeding Disorders-Prevalence, Diagnosis, and Management, with a Special Focus on Congenital Factor XIII Deficiency.

Science.gov (United States)

Alavi, Seyed Ezatolla Rafiee; Jalalvand, Masumeh; Assadollahi, Vahideh; Tabibian, Shadi; Dorgalaleh, Akbar

2018-04-01

Intracranial hemorrhage (ICH) is a medical emergency. In congenital bleeding disorders, ICH is a devastating presentation accompanied with a high rate of morbidity and mortality. The prevalence of ICH is highly variable among congenital bleeding disorders, with the highest incidence observed in factor (F) XIII deficiency (FXIIID) (∼30%). This life-threatening presentation is less common in afibrinogenemia, FVIII, FIX, FVII, and FX deficiencies, and is rare in severe FV and FII deficiencies, type 3 von Willebrand disease and inherited platelet function disorders (IPFDs). In FXIIID, this diathesis most often occurs after trauma in children, whereas spontaneous ICH is more frequent in adults. About 15% of patients with FXIIID and ICH die; the bleeding causes 80% of deaths in this coagulopathy. Although in FXIIID, the bleed most commonly is intraparenchymal (> 90%), epidural, subdural, and subarachnoid hemorrhages also have been reported, albeit rarely. As this life-threatening bleeding causes neurological complications, early diagnosis can prevent further expansion of the hematoma and secondary damage. Neuroimaging plays a crucial role in the diagnosis of ICH, but signs and symptoms in patients with severe FXIIID should trigger replacement therapy even before establishment of the diagnosis. Although a high dose of FXIII concentrate can reduce the rate of morbidity and mortality of ICH in FXIIID, it may occasionally trigger inhibitor development, thus complicating ICH management and future prophylaxis. Nevertheless, replacement therapy is the mainstay of treatment for ICH in FXIIID. Neurosurgery is performed in patients with FXIIID and epidural hematoma and a hemorrhage diameter exceeding 2 cm or a volume of ICH is more than 30 cm 3 . Contact sports are not recommended in people with FXIIID as they can elicit ICH. However, a considerable number of safe sports and activities have been suggested to have more benefits than dangers for patients with congenital bleeding

Chemical mechanisms of histone lysine and arginine modifications

OpenAIRE

Smith, Brian C.; Denu, John M.

2008-01-01

Histone lysine and arginine residues are subject to a wide array of post-translational modifications including methylation, citrullination, acetylation, ubiquitination, and sumoylation. The combinatorial action of these modifications regulates critical DNA processes including replication, repair, and transcription. In addition, enzymes that modify histone lysine and arginine residues have been correlated with a variety of human diseases including arthritis, cancer, heart disease, diabetes, an...

Modification to the lower hybrid system

International Nuclear Information System (INIS)

Gormezano, C.

1989-01-01

The main modifications which have to be done to the Lower Hybrid system are related in the change of the plasma shape in front of the grill mouth. In effect, the theoretical coupling efficiency of the LHCD grill depends only upon the density at the grill mouth and upon the launched wave index. In order to minimize the number of modifications to the launcher it is proposed to modify the length of the vacuum waveguides connecting the multijunctions to the vacuum windows. To obtain the new poloidal contour, it is proposed to recover the L1 multijunctions and to remachine their mouth. (U.K.)

Modeling polyvinyl chloride Plasma Modification by Neural Networks

Science.gov (United States)

Wang, Changquan

2018-03-01

Neural networks model were constructed to analyze the connection between dielectric barrier discharge parameters and surface properties of material. The experiment data were generated from polyvinyl chloride plasma modification by using uniform design. Discharge voltage, discharge gas gap and treatment time were as neural network input layer parameters. The measured values of contact angle were as the output layer parameters. A nonlinear mathematical model of the surface modification for polyvinyl chloride was developed based upon the neural networks. The optimum model parameters were obtained by the simulation evaluation and error analysis. The results of the optimal model show that the predicted value is very close to the actual test value. The prediction model obtained here are useful for discharge plasma surface modification analysis.

Research and development of methods and technologies for CO2 capture in fossil fuel power plants and storage in geological formations in the Czech Republic. Stage 5.4: Boiler with oxyfuel technology. Revision 0

International Nuclear Information System (INIS)

Dlouhy, Tomas

2011-12-01

This phase comprised a preliminary study of boiler design modification for the oxyfuel technology. The design was developed specifically for the Prunerov II power plant. It was defined as a reference boiler for combustion using air which was consequently modified for combustion with oxygen. Changes in the construction of boiler were designed and quantified using thermal conversion, which provided the necessary modification of the sizes of the fireplace and heating surfaces. An existing general mathematical model, modified for this specific task, was used for the thermal conversion calculations

Radiation and nuclear technologies in the Institute for Nuclear Research NAS of Ukraine

International Nuclear Information System (INIS)

Vishnevs'kij, Yi.M.; Gajdar, G.P.; Kovalenko, O.V.; Kovalyins'ka, T.V.; Kolomyijets', M.F.; Lips'ka, A.Yi.; Litovchenko, P.G.; Sakhno, V.Yi.; Shevel', V.M.

2014-01-01

The monograph describes some of the important developments of radiation and nuclear technology, made in INR NAS Ukraine. The first section describes radiation producing new materials and services using electrons with energies up to 5 MeV and Bremsstrahlung X-rays. We describe the original technology using ion emissions of the low and very low energies. In the second section the nuclear technologies, where ions, neutrons and other high-energy particles with energies are used, provide modification of the structure of matter nuclei in particular - radioactive isotopes for industrial and medical supplies and devices based on them.

[Tattoos and piercings: motives for body modification in women suffering from borderline symptomatology].

Science.gov (United States)

Höhner, Gesche; Teismann, Tobias; Willutzki, Ulrike

2014-02-01

Do women suffering from borderline symptomatology differ from women without these symptoms regarding their motives for body modifications?A sample of 289 women with body modifications were questioned about their tattoos, piercings and motives for body modifications as well as about symptoms of borderline personality disorder. Women with borderline symptomatology were compared to women without borderline symptomatology concerning the extent of and motives for body modification.The 2 groups showed no differences in regard to amount and extent of body modifications. The "borderline"-group considered individuality, coping and management of negative life-events to be more crucial reasons for body modification than the non-borderline females.The degree of a person's body modification is not a feasible indicator for psychopathological strain. Though, for people with borderline tendency body modification may serve as a coping strategy similar to self-injury. © Georg Thieme Verlag KG Stuttgart · New York.

Modification of First-line Antiretroviral Therapy in Treatment-naive, HIV Positive Patients

Directory of Open Access Journals (Sweden)

Smita Shenoy

2017-10-01

Full Text Available Introduction: Modification of initial Antiretroviral Therapy (ART program is an important issue in HIV infected patients as the number of ART regimens available is limited. Hence, there is a need to understand the factors that affect modification and therefore, the durability of the initial antiretroviral regimen. Aim: To study the type of modification of first line ART in treatment-naive HIV positive patients and factors influencing it. Materials and Methods: A retrospective observational study was carried out in the HIV clinic of a tertiary care hospital, using data obtained from the case records of the subjects who were initiated on ART between January 2012 to December 2014. Data on patient baseline characteristics, proportion of patients who required modification, type and time of modification was collected. The determinants of time to modification were analysed using Chi-square test. Binomial logistic regression was utilized to assess independent risk factors for change in regimen. Results: Out of 200 case records analysed, 54 patients had to undergo a modification in their initial regimen. The mean age of patients was 44.68 ± 11.31 years. Majority of the patients were males. The most common reason for modification was Adverse Drug Reactions (ADRs (79.63% followed by treatment failure (9.25%. In 85.18% cases, modification involved substitution. Occurrence of ADRs and non-tenofovir based first-line regimens were associated with higher likelihood of substitution in regimen (p<0.05. The median time (IQR to modification was 173 (152.25, 293.50 days. Conclusion: ADRs and the use of non-tenofovir based regimens resulted in significantly higher rates of modification of antiretroviral therapy. There should be monitoring of patients on ART to detect ADRs at the earliest and to obtain increased use of single tablet containing tenofovir based regimen to improve durability of first line regimens.

Identification and Interrogation of Combinatorial Histone Modifications

Directory of Open Access Journals (Sweden)

Kelly R Karch

2013-12-01

Full Text Available Histone proteins are dynamically modified to mediate a variety of cellular processes including gene transcription, DNA damage repair, and apoptosis. Regulation of these processes occurs through the recruitment of non-histone proteins to chromatin by specific combinations of histone post-translational modifications (PTMs. Mass spectrometry has emerged as an essential tool to discover and quantify histone PTMs both within and between samples in an unbiased manner. Developments in mass spectrometry that allow for characterization of large histone peptides or intact protein has made it possible to determine which modifications occur simultaneously on a single histone polypeptide. A variety of techniques from biochemistry, biophysics, and chemical biology have been employed to determine the biological relevance of discovered combinatorial codes. This review first describes advancements in the field of mass spectrometry that have facilitated histone PTM analysis and then covers notable approaches to probe the biological relevance of these modifications in their nucleosomal context.

Characteristic measurements of JRR-2 after modification

International Nuclear Information System (INIS)

1977-03-01

JRR-2 was shut down in December 1973, to improve it in heavy water leakage from the metal packing between core tank and support ring, corrosion of the lower shielding plug, and fault in the control-rod mechanism. Modification was on a standing seal to stop heavy water leakage at the support ring, replacement of the reactor top shield, replacement of the control-rod mechanism, improvement of the helium system, improvement of the irradiated air system to reduce radioactive argon gas release from the stack. Works were completed in September 1975. Functional tests and characteristic measurements then followed, to show good results of the modification. Described are; modification, critical experiments, calibration of the control rods, reactor thermal power, measurements of the neutron flux distribution, core heavy water flow distribution, heavy water decomposition rate, helium leak rate and tritium concentration in the thermal shielding light water, radioactive argon gas release from the stack, and effect of the reactor top shield. (auth.)

48 CFR 252.236-7000 - Modification proposals-price breakdown.

Science.gov (United States)

2010-10-01

...-price breakdown. 252.236-7000 Section 252.236-7000 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.236-7000 Modification proposals—price breakdown. As prescribed in 236.570(a), use the following clause: Modification Proposals—Price Breakdown (DEC 1991) (a) The...

Orbital Atherectomy in the Renal Artery: A New Frontier for an Emerging Technology?

Science.gov (United States)

Valle, Javier A; Armstrong, Ehrin J; Waldo, Stephen W

2017-01-01

Orbital atherectomy has been developed as a method to modify calcified plaque in the peripheral vasculature, with extensive experience and data supporting its use in infrainguinal peripheral arterial disease. However, calcific atherosclerotic disease occurs in other vascular beds and may benefit from the application of this technology. In this case report, we describe the first reported use of orbital atherectomy in a renal artery. A 55-year-old male with severe drug-refractory hypertension was found to have renal artery stenosis, with severe calcification of the right renal artery. Orbital atherectomy was utilized for initial plaque modification, and he underwent stenting of the renal artery lesion with an excellent angiographic and clinical result at follow-up. In conclusion, orbital atherectomy is a safe and effective means of plaque modification for severely calcified lesions. The safe and effective use of orbital atherectomy in the renal vasculature suggests an opportunity for ongoing evaluation into expanded roles for this technology beyond the coronary and lower-extremity arterial beds.

Muonic X-ray intensities in phosphorus- and selenium modifications

International Nuclear Information System (INIS)

Kaeser, K.; Robert-Tissot, B.; Schaller, L.A.; Schellenberg, L.; Schneuwly, H.

1979-01-01

Muonic X-ray intensity measurements have been performed at SIN on allotropic modifications of phosphorus (white, red and black) and of selenium (red and black). Structure effects have been found in the intensity ratios of the K-series between amorphous and crystalline modifications of the same element. The effect in the higher series (Se) is less pronounced. On the other hand, the two crystalline phosphorus modifications (red and black) show the same intensity behavior. The root-mean-square radii 2 >sup(1/2) of phosphorus and (natural) selenium were found to be 3.187(3) fm and 4.138(1) fm respectively. (Auth.)

TEXTILE SURFACE MODIFICATION BY PYHSICAL VAPOR DEPOSITION – (REVIEW

Directory of Open Access Journals (Sweden)

YUCE Ismail

2017-05-01

Full Text Available Textile products are used in various branches of the industry from automotive to space products. Textiles produced for industrial use are generally referred to as technical textiles. Technical textiles are nowadays applied to several areas including transportation, medicine, agriculture, protection, sports, packaging, civil engineering and industry. There are rapid developments in the types of materials used in technical textiles. Therefore, modification and functionalization of textile surfaces is becoming more crucial. The improvements of the properties such as anti-bacterial properties, fire resistivity, UV radiation resistance, electrical conductivity, self cleaning, and super hydrophobic, is getting more concern with respect to developments in textile engineering. The properties of textile surfaces are closely related to the fiber structure, the differences in the polymer composition, the fiber mixture ratio, and the physical and chemical processes applied. Textile surface modifications can be examined in four groups under the name mechanical, chemical, burning and plasma. Surface modifications are made to improve the functionality of textile products. Textile surface modifications affect the properties of the products such as softness, adhesion and wettability. The purpose of this work is to reveal varieties of vapor deposition modifications to improve functionality. For this purpose, the pyhsical vapor deposition methods, their affects on textile products and their end-uses will be reviewed.

Role of Oxidative Stress in Epigenetic Modification in Endometriosis.

Science.gov (United States)

Ito, Fuminori; Yamada, Yuki; Shigemitsu, Aiko; Akinishi, Mika; Kaniwa, Hiroko; Miyake, Ryuta; Yamanaka, Shoichiro; Kobayashi, Hiroshi

2017-11-01

Aberrant DNA methylation and histone modification are associated with an increased risk of reproductive disorders such as endometriosis. However, a cause-effect relationship between epigenetic mechanisms and endometriosis development has not been fully determined. This review provides current information based on oxidative stress in epigenetic modification in endometriosis. This article reviews the English-language literature on epigenetics, DNA methylation, histone modification, and oxidative stress associated with endometriosis in an effort to identify epigenetic modification that causes a predisposition to endometriosis. Oxidative stress, secondary to the influx of hemoglobin, heme, and iron during retrograde menstruation, is involved in the expression of CpG demethylases, ten-eleven translocation, and jumonji (JMJ). Ten-eleven translocation and JMJ recognize a wide range of endogenous DNA methyltransferases (DNMTs). The increased expression levels of DNMTs may be involved in the subsequent downregulation of the decidualization-related genes. This review supports the hypothesis that there are at least 2 distinct phases of epigenetic modification in endometriosis: the initial wave of iron-induced oxidative stress would be followed by the second big wave of epigenetic modulation of endometriosis susceptibility genes. We summarize the recent advances in our understanding of the underlying epigenetic mechanisms focusing on oxidative stress in endometriosis.

Postulated weather modification effects of large energy releases

Energy Technology Data Exchange (ETDEWEB)

Ramsdell, J.V.; Scott, B.C.; Orgill, M.M.; Renne, D.S.; Hubbard, J.E.; McGinnis, K.A.

1977-02-01

Postulated impacts of large energy releases were examined in the light of existing technical information. The magnitudes of direct atmospheric modifications were estimated, and the ecological and economic implications of the modifications were explored. Energy releases from energy centers (10 to 40 power plants at a single site) and individual power plant clusters (1 to 4 power plants) were considered. In the atmosphere the energy will exist initially as increased temperature (sensible heat), moisture (latent heat), and air motion (kinetic energy). Addition of energy could result in increased cloudiness and fog, and changed precipitation patterns. A framework for economic analysis of the impacts of the postulated atmospheric modifications was established on the basis of costs and benefits. Willingness-to-pay was selected as the appropriate measure for valuing each impact. The primary and secondary atmospheric modifications may affect recreation, transportation, and aesthetics as well as agriculture and forestry. Economic values can be placed on some of the effects. However, the willingness of people to pay to gain benefits and avoid damages in many cases can only be determined through extensive surveys. The economic consequences of a given energy release would be highly site specific.

Postulated weather modification effects of large energy releases

International Nuclear Information System (INIS)

Ramsdell, J.V.; Scott, B.C.; Orgill, M.M.; Renne, D.S.; Hubbard, J.E.; McGinnis, K.A.

1977-02-01

Postulated impacts of large energy releases were examined in the light of existing technical information. The magnitudes of direct atmospheric modifications were estimated, and the ecological and economic implications of the modifications were explored. Energy releases from energy centers (10 to 40 power plants at a single site) and individual power plant clusters (1 to 4 power plants) were considered. In the atmosphere the energy will exist initially as increased temperature (sensible heat), moisture (latent heat), and air motion (kinetic energy). Addition of energy could result in increased cloudiness and fog, and changed precipitation patterns. A framework for economic analysis of the impacts of the postulated atmospheric modifications was established on the basis of costs and benefits. Willingness-to-pay was selected as the appropriate measure for valuing each impact. The primary and secondary atmospheric modifications may affect recreation, transportation, and aesthetics as well as agriculture and forestry. Economic values can be placed on some of the effects. However, the willingness of people to pay to gain benefits and avoid damages in many cases can only be determined through extensive surveys. The economic consequences of a given energy release would be highly site specific

Reburning technology - a means to reduce NOx emissions

International Nuclear Information System (INIS)

Kremer, H.; Lorra, M.

1999-01-01

Nitrogen oxide emission control technologies can be classified as either combustion modifications to minimize the NO production or post-combustion flue gas treatment to reduce the NO concentration afterwards. The techniques for minimizing NOx Production includes the use of low-NOx burners, overfire air (staged combustion) and boiler combustion optimization. Procedures for flue gas treatment can be subdivided into selective catalytic reduction (SCR) or selective non-catalytic reduction (SNCR). The re burning process is a selective non-catalytic technology which is applicable to a wide variety of boilers and can be implemented within a relatively short period of time. The NOx reduction potential of this technique is in the range of 50 % up to 70 %. (author)

ENDF/B-5 modifications 1986

International Nuclear Information System (INIS)

McLaughlin, P.K.

1986-05-01

This document summarizes the modifications made to the ENDF/B-5 evaluated neutron data files in 1986. The new versions of the files are available from the IAEA Nuclear Data Section upon request, costfree, on magnetic tape. (author)

Evolution of phage display technology: from discovery to application.

Science.gov (United States)

Rahbarnia, Leila; Farajnia, Safar; Babaei, Hossein; Majidi, Jafar; Veisi, Kamal; Ahmadzadeh, Vahideh; Akbari, Bahman

2017-03-01

Phage display technology as a selection-based system is an attractive method for evolution of new biological drugs. Unique ability of phage libraries for displaying proteins on bacteriophage surfaces enable them to make a major contribution in diverse fields of researches related to the diagnosis and therapy of diseases. One of the great challenges facing researchers is the modification of phage display technology and the development of new applications. This article reviews the molecular basis of phage display library, and summarizes the novel and specific applications of this technique in the field of biological drugs development including therapeutic antibodies, peptides, vaccines, and catalytic antibodies.

INFORMATION SYSTEM QUALITY INFLUENCE ON ORGANIZATION PERFORMANCE: A MODIFICATION OF TECHNOLOGY-BASED INFORMATION SYSTEM ACCEPTANCE AND SUCCESS MODEL

Directory of Open Access Journals (Sweden)

Trisnawati N.

2017-12-01

Full Text Available This study aims to examine the effect of information system quality on technology-based accounting information systems usage and their impact on organizational performance on local government. This study is based on Technology Acceptance Model (TAM, IS Success Model, and the success of technology-based information systems. This study is a combination of previous studies conducted by Seddon and Kiew (1997, Saeed and Helm (2008, and DeLone and McLean (1992. This study used survey method and took 101 respondents from accounting staff working in Malang and Mojokerto regencies. This study uses Partial Least Square to examine research data. Research result exhibits information system qualities affecting benefit perception and user satisfaction. Technology-based accounting information systems usage in local government is influenced by benefits perception and user satisfaction. Research result concluded that technology-based accounting information systems usage will affect the performance of local government organizations.

Energy conversion and utilization technologies

International Nuclear Information System (INIS)

1988-01-01

The DOE Energy Conversion and Utilization Technologies (ECUT) Program continues its efforts to expand the generic knowledge base in emerging technological areas that support energy conservation initiatives by both the DOE end-use sector programs and US private industry. ECUT addresses specific problems associated with the efficiency limits and capabilities to use alternative fuels in energy conversion and end-use. Research is aimed at understanding and improving techniques, processes, and materials that push the thermodynamic efficiency of energy conversion and usage beyond the state of the art. Research programs cover the following areas: combustion, thermal sciences, materials, catalysis and biocatalysis, and tribology. Six sections describe the status of direct contact heat exchange; the ECUT biocatalysis project; a computerized tribology information system; ceramic surface modification; simulation of internal combustion engine processes; and materials-by-design. These six sections have been indexed separately for inclusion on the database. (CK)

Epigenetic modifications in prostate cancer.

Science.gov (United States)

Ngollo, Marjolaine; Dagdemir, Aslihan; Karsli-Ceppioglu, Seher; Judes, Gaelle; Pajon, Amaury; Penault-Llorca, Frederique; Boiteux, Jean-Paul; Bignon, Yves-Jean; Guy, Laurent; Bernard-Gallon, Dominique J

2014-01-01

Prostate cancer is the most common cancer in men and the second leading cause of cancer deaths in men in France. Apart from the genetic alterations in prostate cancer, epigenetics modifications are involved in the development and progression of this disease. Epigenetic events are the main cause in gene regulation and the three most epigenetic mechanisms studied include DNA methylation, histone modifications and microRNA expression. In this review, we summarized epigenetic mechanisms in prostate cancer. Epigenetic drugs that inhibit DNA methylation, histone methylation and histone acetylation might be able to reactivate silenced gene expression in prostate cancer. However, further understanding of interactions of these enzymes and their effects on transcription regulation in prostate cancer is needed and has become a priority in biomedical research. In this study, we summed up epigenetic changes with emphasis on pharmacologic epigenetic target agents.

Effect of Factor XIII-A G185T Polymorphism on Visual Prognosis after Photodynamic Therapy for Neovascular Macular Degeneration

Directory of Open Access Journals (Sweden)

Francesco Parmeggiani

2015-08-01

Full Text Available Macular degenerations represent leading causes of central blindness or low vision in developed countries. Most of these severe visual disabilities are due to age-related macular degeneration (AMD and pathologic myopia (PM, both of which are frequently complicated by subfoveal choroidal neovascularization (CNV. Photodynamic therapy with verteporfin (PDT-V is still employed for CNV treatment in selected cases or in combined regimen. In Caucasian patients, the common polymorphism G185T of factor XIII-A gene (FXIII-A-G185T; rs5985 has been described as predictor of poor angiographic CNV responsiveness to PDT-V. Nevertheless, the prognostic implications of this pharmacogenetic determinant on long-term visual outcome after a PDT-V regimen have not been evaluated. We retrospectively selected Caucasian patients presenting with treatment-naive CNV and receiving standardized PDT-V protocol for two years. The study population included patients affected by subfoveal CNV secondary to AMD or PM. We assessed the correlations between the polymorphic allele T of FXIII-A-G185T and: (1 total number of photodynamic treatments; and (2 change in visual acuity from baseline to the end of the follow-up period. Considering a total study population of 412 patients with neovascular AMD or PM, the carriers of 185 T-allele of FXIII-A (GT or TT genotype received a higher number of photodynamic treatments than patients without it (GG wild-type genotype (p < 0.01; mean number of PDT-V: 5.51 vs. 3.76, respectively. Moreover, patients with 185 T-allele of FXIII-A had a more marked worsening of visual acuity at 24 months than those with the GG-185 wild genotype (p < 0.01; mean difference in logMAR visual acuity: 0.22 vs. 0.08, respectively. The present findings show that the G185T polymorphism of the FXIII-A gene is associated with significant differences in the long-term therapeutic outcomes of patients treated with standardized PDT-V protocol. The comprehensive appraisal of

Structural dynamic modifications via models

Indian Academy of Sciences (India)

The study shows that as many as half of the matrix ... the dynamicist's analytical modelling skill which would appear both in the numerator as. Figure 2. ..... Brandon J A 1990 Strategies for structural dynamic modification (New York: John Wiley).

Synthesis of Silicalite Membrane with an Aluminum-Containing Surface for Controlled Modification of Zeolitic Pore Entries for Enhanced Gas Separation

Directory of Open Access Journals (Sweden)

Shaowei Yang

2018-02-01

Full Text Available The separation of small molecule gases by membrane technologies can help performance enhancement and process intensification for emerging advanced fossil energy systems with CO2 capture capacity. This paper reports the demonstration of controlled modification of zeolitic channel size for the MFI-type zeolite membranes to enhance the separation of small molecule gases such as O2 and N2. Pure-silica MFI-type zeolite membranes were synthesized on porous α-alumina disc substrates with and without an aluminum-containing thin skin on the outer surface of zeolite membrane. The membranes were subsequently modified by on-stream catalytic cracking deposition (CCD of molecular silica to reduce the effective openings of the zeolitic channels. Such a pore modification caused the transition of gas permeation from the N2-selective gaseous diffusion mechanism in the pristine membrane to the O2-selective activated diffusion mechanism in the modified membrane. The experimental results indicated that the pore modification could be effectively limited within the aluminum-containing surface of the MFI zeolite membrane to minimize the mass transport resistance for O2 permeation while maintaining its selectivity. The implications of pore modification on the size-exclusion-enabled gas selectivity were discussed based on the kinetic molecular theory. In light of the theoretical analysis, experimental investigation was performed to further enhance the membrane separation selectivity by chemical liquid deposition of silica into the undesirable intercrystalline spaces.

Milliken Clean Coal Technology Demonstration Project. Environmental monitoring report, July--September 1996

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-05-01

New York State Electric and Gas Corporation (NYSEG) has installed and is presently operating a high-efficiency flue gas desulfurization (FGD) system to demonstrate innovative emissions control technology and comply with the Clean Air Act Amendments of 1990. The host facility for this demonstration project is NYSEG`s Milliken Station, in the Town of Lansing, New York. The primary objective of this project is to demonstrate a retrofit of energy-efficient SO{sub 2} and NO{sub x} control systems with minimal impact on overall plant efficiency. The demonstration project has added a forced oxidation, formic acid-enhanced wet limestone FGD system, which is expected to reduce SO{sub 2} emissions by at least 90 percent. NYSEG also made combustion modifications to each boiler and plans to demonstrate selective non-catalytic reduction (SNCR) technology on unit 1, which will reduce NO{sub x} emissions. Goals of the proposed demonstration include up to 98 percent SO{sub 2} removal efficiency while burning high-sulfur coal, 30 percent NO{sub x} reductions through combustion modifications, additional NO{sub x} reductions using SNCR technology, production of marketable commercial-grade gypsum and calcium chloride by-products to minimize solid waste disposal, and zero wastewater discharge.

PREFACE Surface Modifications and Functionalization of Materials for Biomedical Applications

Science.gov (United States)

Endrino, Jose Luis; Puértolas, Jose A.; Albella, Jose M.

2010-11-01

Conference photograph This special issue contains selected papers which were presented as invited and contributed communications at the workshop entitled 'Surface modification and functionalization of materials for biomedical applications' (BIO-COAT 2010) which was held on 24 June 2010 in Zaragoza (Spain). The surface of a material plays a major role in its interaction with the biological medium. Processes related to the mechanical stability of articular devices in contact, osseointegration, thrombogenicity, corrosion and leaching, or the inflammatory response of rejection of a material, are clearly conditioned by the surface properties. Therefore, the modification or functionalization of surfaces can have an important impact on these issues. New techniques for functionalization by thin film deposition or surface treatments help to improve superficial properties, while understanding the interaction of the surface-biological medium is critical for their application in new devices. Jointly organized by the Spanish Materials Research Society, BIO-COAT 2010 provided an open forum to discuss the progress and latest developments in thin film processing and the engineering of biomaterials. Invited lectures were particularly aimed at providing overviews on scientific topics and were given by recognized world-class scientists. Two of them have contributed with a proceedings article to this selected collection (articles 012001 and 012008). The contributed communications were focused on particular cutting-edge aspects of thin film science and functionalization technologies for biomaterials, showing the major scientific push of Spanish research groups in the field. The 2010 BIO-COAT conference was organized along four main topics: (1) functionalization and texture on surfaces, (2) tribology and corrosion, (3) the surface modification of biomaterials, and (4) surface-biological environment interactions. The papers published in this volume were accepted for publication after

Cellular modifications produced by D2O in yeast culture

International Nuclear Information System (INIS)

Mihancea, I.; Mircea, R.Al.

1996-01-01

The cellular cycle of the Saccharomyces Cerevisiae, chosen as experimental object, is unmodified by the presence in the culture medium of D 2 O at different concentrations. An increased concentration of D 2 O in the culture medium leads to a decrease of the number of budded cells, to metabolic alterations, to DNA structure modification as well as to enzymatic changes produced by blocking. Other anomalies appear, as a function of the cell defence capacity and of the influence of the factors from the nutrient substrate or exterior medium. Due to D 2 O, the medium's pH changes and modifications at the enzyme level and of the cell microstructure and morphology occur. The enzymatic reactions take place in D 2 O slower than in H 2 O. Three-dimensional modifications appear in the organic components of the live cell which, in turn, produce profound modifications in the cell growth and division. Due to the kinetic and isotopic effects, modifications of the biochemical reactions affecting the cell integrity happen

Guidance on the Implementation of Modifications to Mitigate Beyond Design Basis Accidents

Energy Technology Data Exchange (ETDEWEB)

Dermarkar, F.; Marczak, J.; O’Neill, M., E-mail: fred.dermarkar@opg.com [Ontario Power Generation, Pickering, Ontario (Canada)

2014-10-15

Following the events at Fukushima, Canadian Nuclear Power Plants (NPP) procured equipment and initiated modifications to improve response capability for Beyond Design Basis Accidents (BDBA). These changes were not typical of other design modifications to the nuclear power plants and reinforced the need for additional guidance for modifications to address BDBA. This paper describes the guidance that was developed to guide the design, procurement, installation, operation, and maintenance of equipment and modifications to mitigate BDBAs. The guidance developed prescribes a graded approach based on a categorization of the nature of the modification. Four categories of modifications are introduced, with the distinction being the degree of interface with existing design basis systems, structures and components (SSCs). This has resulted in a cost-effective means of implementing additional capability to mitigate BDBA conditions, and yet ensure the design basis capability of SSCs is maintained. (author)

Y-12 Industrial Landfill V. Permit application modifications

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-09-01

This report contains the modifications in operations and design to meet the Tennessee Department of Environment and Conversation (TDEC) July 10, 1993, amendments to the regulations for Class 2 landfills. These modifications, though extensive in design and construction cost, are considered minor revisions and should not require a processing fee. Area 1 of ILF V, comprising approximately 20% of the ILF V footprint, was designed and submitted to TDEC prior to the implementation of current regulations. This initial area was constructed with a compacted clay liner and leachate collection system, and became operational in April 1994. The current regulations require landfills to have a composite liner with leachate collection system and closure cap. Modifications to upgrade Areas 2 and 3 of ILF V to meet the current TDEC requirements are included.