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Sample records for models red king

  1. Effects of ocean acidification on fishery yields and profits of red king crab in Bristol Bay from model studies (NCEI Accession 0127395)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This archival package contains model output data that were collected to examine the impact of ocean acidification on fishery yields and profits of red king crab in...

  2. Modelling of population dynamics of red king crab using Bayesian approach

    Directory of Open Access Journals (Sweden)

    Bakanev Sergey ...

    2012-10-01

    Modeling population dynamics based on the Bayesian approach enables to successfully resolve the above issues. The integration of the data from various studies into a unified model based on Bayesian parameter estimation method provides a much more detailed description of the processes occurring in the population.

  3. The shift between the Red Queen and the Red King effects in mutualisms.

    Science.gov (United States)

    Gao, Lei; Li, Yao-Tang; Wang, Rui-Wu

    2015-02-04

    Interspecific mutualisms consist of partners trading services that yield common benefits to both species. Until now, understanding how the payoffs from mutualistic cooperation are allocated among the participants has been problematic. Two hypotheses have been proposed to resolve this problem. The Red Queen effect argues that faster-evolving species are favoured in co-evolutionary processes because they are able to obtain a larger share of benefits. Conversely, the Red King effect argues that the slower-evolving species gains a larger share of benefits. The model we propose shows that the allocations for a common benefit vary when the effect of a reward mechanism is included in the model. The outcome is a shift from the Red Queen effect to the Red King effect and vice versa. In addition, our model shows that either an asymmetry in payoff or an asymmetry in the number of cooperative partners causes a shift between the Red Queen effect and the Red King effect. Even in situations where the evolutionary rates are equal between the two species, asymmetries in rewards and in participant number lead to an uneven allocation of benefits among the partners.

  4. The Red Queen and King in finite populations.

    Science.gov (United States)

    Veller, Carl; Hayward, Laura K; Hilbe, Christian; Nowak, Martin A

    2017-07-03

    In antagonistic symbioses, such as host-parasite interactions, one population's success is the other's loss. In mutualistic symbioses, such as division of labor, both parties can gain, but they might have different preferences over the possible mutualistic arrangements. The rates of evolution of the two populations in a symbiosis are important determinants of which population will be more successful: Faster evolution is thought to be favored in antagonistic symbioses (the "Red Queen effect"), but disfavored in certain mutualistic symbioses (the "Red King effect"). However, it remains unclear which biological parameters drive these effects. Here, we analyze the effects of the various determinants of evolutionary rate: generation time, mutation rate, population size, and the intensity of natural selection. Our main results hold for the case where mutation is infrequent. Slower evolution causes a long-term advantage in an important class of mutualistic interactions. Surprisingly, less intense selection is the strongest driver of this Red King effect, whereas relative mutation rates and generation times have little effect. In antagonistic interactions, faster evolution by any means is beneficial. Our results provide insight into the demographic evolution of symbionts.

  5. AFSC/RACE/SAP/Cummiskey: Red king crab sonic tagging and dive database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This is data from a long-term monitoring project which utilized sonic tags to follow aggregations of red king crab in Womens Bay near Kodiak Alaska. The database...

  6. AFSC/RACE/SAP/Swiney: Red king crab fecundity and embryo and larval quality

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Stock assessment of Alaskan red king crab, Paralithodes camtschaticus (Tilesius, 1815), can be improved by incorporating reproductive output, which requires an...

  7. AFSC/RACE/GAP/Nichol: Archival tag depth and temperature data from red king crab

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — In December of 2009, a total of 135 adult male red king crab (Paralithodes camtschaticus) were tagged with depth and temperature recording archival tags and released...

  8. AFSC/RACE/SAP/Long: Data from: Habitat, predation, growth, and coexistence: Could interactions between juvenile red and blue king crabs limit blue king crab productivity?

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is from a series of laboratory experiments examining the interactions between red and blue king crabs and habitat. We examined how density and predator...

  9. King Cove, Alaska Tsunami Forecast Grids for MOST Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The King Cove, Alaska Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST) model. MOST...

  10. AFSC/RACE/SAP/Long: Data from: Upper thermal tolerance in red and blue king crab: Sublethal and lethal effects

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains data from a series of experiments that determined the upper thermal tolerance of early benthic stage red and blue king crabs. Experiments...

  11. Eocene age of the Baranowski Glacier Group at Red Hill, King George Island, West Antarctica

    Directory of Open Access Journals (Sweden)

    Mozer Anna

    2015-12-01

    Full Text Available Radiometric and geochemical studies were carried out at Red Hill in the southern part of King George Island (South Shetland Islands, northern Antarctic Peninsula on the Bransfield Strait coast. The rock succession at Red Hill has been determined to represent the Baranowski Glacier Group that was previously assigned a Late Cretaceous age. Two formations were distinguished within this succession: the lower Llano Point Formation and the upper Zamek Formation. These formations have stratotypes defined further to the north on the western coast of Admiralty Bay. On Red Hill the Llano Point Formation consists of terrestrial lavas and pyroclastic breccia; the Zamek Formation consist predominantly of fine to coarse tuff, pyroclastic breccia, lavas, tuffaceous mud-, silt-, and sandstone, locally conglomeratic. The lower part of the Zamek Formation contains plant detritus (Nothofagus, dicotyledonous, thermophilous ferns and numerous coal seams (vitrinitic composition that confirm the abundance of vegetation on stratovolcanic slopes and surrounding lowlands at that time. Selected basic to intermediate igneous rocks from the succession have been analysed for the whole-rock K-Ar age determination. The obtained results indicate that the Red Hill succession was formed in two stages: (1 from about 51–50 Ma; and (2 46–42 Ma, i.e. during the Early to Middle Eocene. This, in combination with other data obtained from other Baranowski Glacier Group exposures on western coast of Admiralty Bay, confirms the recently defined position of the volcano-clastic succession in the stratigraphic scheme of King George Island. The new stratigraphic position and lithofacies development of the Red Hill succession strongly suggest its correlation with other Eocene formations containing fossil plants and coal seams that commonly occur on King George Island.

  12. Development of a real-time PCR assay for detection of planktonic red king crab (Paralithodes camtschaticus (Tilesius 1815)) larvae

    Science.gov (United States)

    Jensen, Pamela C.; Purcell, Maureen K.; Morado, J. Frank; Eckert, Ginny L.

    2012-01-01

    The Alaskan red king crab (Paralithodes camtschaticus) fishery was once one of the most economically important single-species fisheries in the world, but is currently depressed. This fishery would benefit from improved stock assessment capabilities. Larval crab distribution is patchy temporally and spatially, requiring extensive sampling efforts to locate and track larval dispersal. Large-scale plankton surveys are generally cost prohibitive because of the effort required for collection and the time and taxonomic expertise required to sort samples to identify plankton individually via light microscopy. Here, we report the development of primers and a dual-labeled probe for use in a DNA-based real-time polymerase chain reaction assay targeting the red king crab, mitochondrial gene cytochrome oxidase I for the detection of red king crab larvae DNA in plankton samples. The assay allows identification of plankton samples containing crab larvae DNA and provides an estimate of DNA copy number present in a sample without sorting the plankton sample visually. The assay was tested on DNA extracted from whole red king crab larvae and plankton samples seeded with whole larvae, and it detected DNA copies equivalent to 1/10,000th of a larva and 1 crab larva/5mL sieved plankton, respectively. The real-time polymerase chain reaction assay can be used to screen plankton samples for larvae in a fraction of the time required for traditional microscopial methods, which offers advantages for stock assessment methodologies for red king crab as well as a rapid and reliable method to assess abundance of red king crab larvae as needed to improve the understanding of life history and population processes, including larval population dynamics.

  13. The complete mitochondrial genome of the subarctic red king crab, Paralithodes camtschaticus (Decapoda, Anomura).

    Science.gov (United States)

    Kim, Sanghee; Choi, Han-Gu; Park, Joong-Ki; Min, Gi-Sik

    2013-08-01

    We determined the complete mitochondrial (mt) genome sequence of the red king crab, Paralithodes camtschaticus (Decapoda, Anomura). P. camtschaticus is one of the largest arthropods and the most expensive commercially available gourmet seafood. The genome sequence of P. camtschaticus is 16,720 bp in size and its gene content, gene order, and transcriptional polarity are almost identical to those of the hermit crab Pagurus longicarpus, which is thought to be derived from a common ancestor. However, P. camtschaticus mtDNA showed tRNA translocation in two blocks compared to that of P. longicarpus. Prior to this study, complete mt genomes of only two species of Anomura have been reported. Thus, our genomic data will provide additional information for constructing the decapod phylogeny.

  14. King Cove, Alaska Coastal Digital Elevation Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA's National Geophysical Data Center (NGDC) is building high-resolution digital elevation models (DEMs) for select U.S. coastal regions. These integrated...

  15. [Understanding King's model on the paradigm of symbolic interactionism].

    Science.gov (United States)

    Araújo, Iliana Maria de Almeida; Oliveira, Marcos Venícios; de Oliveira, Marcos Venícius; Fernandes, Ana Fátima Carvalho

    2005-01-01

    It was aimed to reflect on King's Theory, according to the approach of Symbolic Interaccionism, and theory analyses model of Meleis. To reach the objective, we proceeded the reading of the three models as mentioned before, looking for the consistencies and discrepancies among the concepts and correlating them. The study allowed to conclude that the theories agree when elucidating the man as a being that reacts and search to understand the meaning of things to his/her circuit, drifting and judging their actions and the one of the other ones. It is important the subject of the meanings could be modified and they generate the elaboration of goals in common.

  16. AFSC/RACE/SAP/Long: Data from: Effects of Ocean Acidification on Juvenile Red King Crab (Paralithodes camtschaticus) and Tanner Crab (Chionoecetes bairdi) Growth, Condition, Calcification, and Survival

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is the results of a laboratory experiment. Juvenile red king crab and Tanner crab were reared in individual containers for nearly 200 days in flowing...

  17. AFSC/RACE/SAP/Daly: Juvenile red and blue king crab prey preference experiment conducted in the Kodiak Lab in 2014

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is part of a laboratory experiment, which evaluated how varying ratios of prey species (year-0 blue and red king crabs) and habitat type (shell and...

  18. AFSC/RACE/SAP/Long: Effects of ocean acidification on respiration, feeding, and growth of juvenile red and blue king crabs (Paralithodes camtschaticus and P. platypus)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Juvenile red and blue king crabs (Paralithodes camtschaticus and P. platypus) were exposed to three pH levels: ambient (pH 8.1), pH 7.8, and pH 7.5 for three weeks....

  19. Structural and functional changes of soft-bottom ecosystems in northern fjords invaded by the red king crab (Paralithodes camtschaticus)

    Science.gov (United States)

    Oug, Eivind; Sundet, Jan H.; Cochrane, Sabine K. J.

    2018-04-01

    The red king crab invaded Norwegian coastal waters in the early 1990s after having been introduced from the northern Pacific to the Russian Barents Sea coast. The crab stock increased rapidly in NE northern Norway in the latter half of the 1990s, and since 2002 there has been a commercial fishery in the eastern invaded areas. The crab is an active predator on benthic fauna especially feeding in deep soft-bottom environments. The present study is a follow-up of previous studies (2007-09) to assess the effects of the king crab predation on soft bottom species composition, ecological functioning and sediment quality. Macroinfauna (> 1 mm) was investigated in three fjord areas in the Varanger region with low, moderate and very high crab abundances, respectively. Compared with data from 1994, most benthic species were markedly reduced in abundance, in particular non-moving burrowing and tube-dwelling polychaetes, bivalves and echinoderms. However, a few species appeared to recover from 2007-09 to 2012. Changes in ecological functioning were assessed using 'biological traits analysis (BTA)'. Following the crab invasion there was a relative reduction of suspension and surface deposit feeding species, an increase in mobile and predatory organisms and an increase in those with planktotrophic larval development. From low to high crab abundances functioning changed from tube-building, deep deposit feeding and fairly large size to free-living, shallow burrowing and rather small size. With regard to sediment reworking, downward and upward conveyors were reduced whereas surficial modifiers increased. The changes imply that sediment biomixing and bioirrigation were reduced leading to a degraded sedimentary environment. It is suggested that establishing relationships between ecosystem functioning and crab abundances may form the basis for estimating ecological costs of the crab invasion. Such knowledge is important for managing the crab in the Barents Sea area being both a non

  20. The Red Queen and her king: cooperation at all levels of life.

    Science.gov (United States)

    Weiss, Kenneth M; Buchanan, Anne V; Lambert, Brian W

    2011-01-01

    The Red Queen in "Through the Looking Glass" is often used as a metaphor for the relentless, unremitting competitive struggle by which Darwin described life. That imagery fits comfortably in our culture, with its emphasis on competition and inequity, but less so for nature herself. Life is manifestly much more about cooperation, at all levels and through a variety of ubiquitous mechanisms, than it is about competition. Most organisms of most species are nowhere near the proverbial Malthusian edge of survival, such that selection will detect the tiniest difference in their performance and enhance its genetic basis. Cooperation through interaction of multiple entities is inherent in many fundamental aspects of life, and its importance is not widely enough appreciated. Here we discuss a set of principles by which this works. We illustrate the points with a computer simulation of a topic of interest to anthropology, the development of the head. In a sense, our culture has its metaphors reversed. The red royal family is a more accurate symbol for the true nature of life, human or otherwise. Copyright © 2011 Wiley Periodicals, Inc.

  1. The leaders King Sverre and King Haakon : analysis of King Sverre Sigurdsson and King Haakon Haakonsson in Sverris Saga and Haakonar Saga Haakonarsonar through Max Weber's and John Gardner's models

    OpenAIRE

    Osornio, Ismael Jose Duran

    2004-01-01

    The leadership of the Norwegian Kings during the Medieval ‘Civil War’ plays a prominent part in social, political and economical life in high Medieval Norway. The objective of the present dissertation discusses how King Sverre Sigurdsson (1177-1202) and Haakon Haakonsson (1217-1263) are depicted in their Sagas. The work will be focus on four analytical tools: 1. The Kings’ Charisma; 2. The Kings’ Personal Abilities; 3. The Kings’ Bureaucracy; 4. The King’s closest Fellows. The thesis goal wil...

  2. Making Kings.

    Science.gov (United States)

    Ayoup, Colleen; Podmore, Julie

    2002-01-01

    Due to a general lack of representation of female masculinities within the North American media, most urban drag king cultures have evolved in isolation from each other. As a result, drag kings tend to develop locally specific codes of dress, performance styles and forms of masculinity. This chapter describes the case of a group of Montreal drag king performers, The Mambo Drag Kings (MDKs). It is based on interviews that were conducted for Colleen Ayoup's film Kings (2001), a short documentary that explores kinging by examining the development of this specific group of performers. We present excerpts from our discussions regarding the relationships between everyday gender identities, lesbian sexuality, and performing as a king in a society that is fundamentally based on an asymmetrical sex-gender system. While the chapter does highlight these theoretical concerns, the focus is on how the participants of the group interpret and experience kinging and its impact on their own gendered and sexual identities.

  3. Statistical Modeling of Extreme Values and Evidence of Presence of Dragon King (DK) in Solar Wind

    Science.gov (United States)

    Gomes, T.; Ramos, F.; Rempel, E. L.; Silva, S.; C-L Chian, A.

    2017-12-01

    The solar wind constitutes a nonlinear dynamical system, presenting intermittent turbulence, multifractality and chaotic dynamics. One characteristic shared by many such complex systems is the presence of extreme events, that play an important role in several Geophysical phenomena and their statistical characterization is a problem of great practical relevance. This work investigates the presence of extreme events in time series of the modulus of the interplanetary magnetic field measured by Cluster spacecraft on February 2, 2002. One of the main results is that the solar wind near the Earth's bow shock can be modeled by the Generalized Pareto (GP) and Generalized Extreme Values (GEV) distributions. Both models present a statistically significant positive shape parameter which implyies a heavy tail in the probability distribution functions and an unbounded growth in return values as return periods become too long. There is evidence that current sheets are the main responsible for positive values of the shape parameter. It is also shown that magnetic reconnection at the interface between two interplanetary magnetic flux ropes in the solar wind can be considered as Dragon Kings (DK), a class of extreme events whose formation mechanisms are fundamentally different from others. As long as magnetic reconnection can be classified as a Dragon King, there is the possibility of its identification and even its prediction. Dragon kings had previously been identified in time series of financial crashes, nuclear power generation accidents, stock market and so on. It is believed that they are associated with the occurrence of extreme events in dynamical systems at phase transition, bifurcation, crises or tipping points.

  4. Estimate Submarine Groundwater Discharge to Crystal River/Kings Bay in Florida with the Help of a Hydrodynamic Model

    Directory of Open Access Journals (Sweden)

    XinJian Chen

    2014-01-01

    Full Text Available Crystal River/Kings Bay is a spring-fed estuarine system located on the west coast of the Florida peninsula. During 2008-2009, a field investigation was conducted to measure submarine groundwater discharges (SGDs from numerous spring vents in Kings Bay. Based on directly measured real-time SGD data, an empirical relationship that links SGD with tides in Kings Bay and the groundwater level measured in a nearby Artesian well were obtained. A 3D unstructured Cartesian grid model was used to help verify the correctness of the empirical SGD formula, which was slightly adjusted for each individual vent when used in the model. The model was calibrated and verified against measured real-time data of water level, salinity, and temperature at two stations in the estuary. A successful simulation of circulations, salinity transport processes, and thermodynamics in the Crystal River/Kings Bay system proves that the empirical relationship is appropriate for estimating SGDs in Kings Bay.

  5. Reassessment of the cardio-respiratory stress response, using the king penguin as a model.

    Science.gov (United States)

    Willener, Astrid S T; Halsey, Lewis G; Strike, Siobhán; Enstipp, Manfred R; Georges, Jean-Yves; Handrich, Yves

    2015-01-01

    Research in to short-term cardio-respiratory changes in animals in reaction to a psychological stressor typically describes increases in rate of oxygen consumption (V̇(O2)) and heart rate. Consequently, the broad consensus is that they represent a fundamental stressor response generalizable across adult species. However, movement levels can also change in the presence of a stressor, yet studies have not accounted for this possible confound on heart rate. Thus the direct effects of psychological stressors on the cardio-respiratory system are not resolved. We used an innovative experimental design employing accelerometers attached to king penguins (Aptenodytes patagonicus) to measure and thus account for movement levels in a sedentary yet free-to-move animal model during a repeated measures stress experiment. As with previous studies on other species, incubating king penguins (N = 6) exhibited significant increases in both V̇(O2) and heart rate when exposed to the stressor. However, movement levels, while still low, also increased in response to the stressor. Once this was accounted for by comparing periods of time during the control and stress conditions when movement levels were similar as recorded by the accelerometers, only V̇(O2) significantly increased; there was no change in heart rate. These findings offer evidence that changing movement levels have an important effect on the measured stress response and that the cardio-respiratory response per se to a psychological stressor (i.e. the response as a result of physiological changes directly attributable to the stressor) is an increase in V̇(O2) without an increase in heart rate.

  6. Ovicides paralithodis (Nemertea, Carcinonemertidae), a new species of symbiotic egg predator of the red king crab Paralithodes camtschaticus (Tilesius, 1815) (Decapoda, Anomura)

    Science.gov (United States)

    Kajihara, Hiroshi; Kuris, Armand M.

    2013-01-01

    Abstract Ovicides paralithodis sp. n. is described from the egg mass of the red king crab Paralithodes camtschaticus (Tilesius, 1815) from the Sea of Okhotsk, off Hokkaido, Japan, and Alaska, USA. Among four congeners, Ovicides paralithodis can be distinguished from Ovicides julieae Shields, 2001 and Ovicides davidi Shields and Segonzac, 2007 by having no eyes; from Ovicides jonesi Shields and Segonzac, 2007 by the presence of basophilic, vacuolated glandular lobes in the precerebral region; and from Ovicides jasoni Shields and Segonzac, 2007 by the arrangement of the acidophilic submuscular glands, which are not arranged in a row. Ovicides paralithodis represents the third described species of egg-predatory nemertean from Paralithodes camtschaticus, the second described carcinonemertid species from Japan, and the 21st described species in the family. The intensity of infestations may exceed 24,000 worms per a single egg-bearing pleopod of Paralithodes camtschaticus. A preliminary molecular phylogenetic analysis based on sequences of 28S rRNA and cytochrome c oxidase subunit I genes among selected monostiliferous hoplonemertean species supported the monophyly of Carcinonemertidae, suggesting that within the lineage of the family, evolution of the unique vas deferens, Takakura’s duct, preceded loss of accessory stylets and accessory-stylet pouches. PMID:23653496

  7. Ovicides paralithodis (Nemertea, Carcinonemertidae, a new species of symbiotic egg predator of the red king crab Paralithodes camtschaticus (Tilesius, 1815 (Decapoda, Anomura

    Directory of Open Access Journals (Sweden)

    Hiroshi Kajihara

    2013-01-01

    Full Text Available Ovicides paralithodis sp. n. is described from the egg mass of the red king crab Paralithodes camtschaticus (Tilesius, 1815 from the Sea of Okhotsk, off Hokkaido, Japan, and Alaska, USA. Among four congeners, O. paralithodis can be distinguished from O. julieae Shields, 2001 and O. davidi Shields and Segonzac, 2007 byno eyes; from O. jonesi Shields and Segonzac, 2007 by the presence of basophilic, vacuolated glandular lobes in the precerebral region; and from O. jasoni Shields and Segonzac, 2007 by the arrangement of the acidophilic submuscular glands, which are not arranged in a row. Ovicides paralithodis represents the third described species of egg-predatory nemertean from P. camtschaticus, the second described carcinonemertid species from Japan, and the 21st described species in the family. The intensity of infestations may exceed 24,000 worms per a single egg-bearing pleopod of P. camtschaticus. A preliminary molecular phylogenetic analysis based on sequences of 28S rRNA and cytochrome c oxidase subunit I genes among selected monostiliferous hoplonemertean species supported the monophyly of Carcinonemertidae, suggesting that within the lineage of the family, evolution of the unique vas deferens, Takakura’s duct, preceded loss of accessory stylets and accessory-stylet pouches.

  8. The Red Sea Modeling and Forecasting System

    KAUST Repository

    Hoteit, Ibrahim

    2015-04-01

    Despite its importance for a variety of socio-economical and political reasons and the presence of extensive coral reef gardens along its shores, the Red Sea remains one of the most under-studied large marine physical and biological systems in the global ocean. This contribution will present our efforts to build advanced modeling and forecasting capabilities for the Red Sea, which is part of the newly established Saudi ARAMCO Marine Environmental Research Center at KAUST (SAMERCK). Our Red Sea modeling system compromises both regional and nested costal MIT general circulation models (MITgcm) with resolutions varying between 8 km and 250 m to simulate the general circulation and mesoscale dynamics at various spatial scales, a 10-km resolution Weather Research Forecasting (WRF) model to simulate the atmospheric conditions, a 4-km resolution European Regional Seas Ecosystem Model (ERSEM) to simulate the Red Sea ecosystem, and a 1-km resolution WAVEWATCH-III model to simulate the wind driven surface waves conditions. We have also implemented an oil spill model, and a probabilistic dispersion and larval connectivity modeling system (CMS) based on a stochastic Lagrangian framework and incorporating biological attributes. We are using the models outputs together with available observational data to study all aspects of the Red Sea circulations. Advanced monitoring capabilities are being deployed in the Red Sea as part of the SAMERCK, comprising multiple gliders equipped with hydrographical and biological sensors, high frequency (HF) surface current/wave mapping, buoys/ moorings, etc, complementing the available satellite ocean and atmospheric observations and Automatic Weather Stations (AWS). The Red Sea models have also been equipped with advanced data assimilation capabilities. Fully parallel ensemble-based Kalman filtering (EnKF) algorithms have been implemented with the MITgcm and ERSEM for assimilating all available multivariate satellite and in-situ data sets. We

  9. Technical feasibility of using gallery intakes for seawater RO facilities, northern Red Sea coast of Saudi Arabia: The King Abdullah Economic City site

    KAUST Repository

    Dehwah, Abdullah

    2013-02-13

    The Kingdom of Saudi Arabia is dependent on desalination of seawater to provide new water supplies for the future. Desalination is expensive and it is very important to reduce the cost and lower the energy consumption. Most seawater reverse osmosis facilities use open-ocean intakes, which require extensive pretreatment processes to remove particulate and biological materials that cause operating problems such as membrane fouling or shutdown during algal blooms. Subsurface systems, using the concept of riverbank filtration, can be used as intakes. These systems include wells of various designs and galleries that provide natural filtration and biological treatment to improve the quality of feed water before it enters the desalination plant. This reduces operating cost, lowers chemical and energy consumption, and reduces environmental impacts. Technical feasibility of gallery-type intakes, beach and seabed types, for use as intakes to seawater reverse osmosis (RO) facilities was evaluated along the northern Red Sea shoreline of Saudi Arabia. The geological characteristics of the offshore ocean bottom were found to be favorable for the development of seabed gallery systems, but the shoreline geology was not adequate for the development of beach gallery intakes. One of the potentially favorable sites for a seabed gallery system was located in the nearshore area at King Abdullah Economic City (KAEC). Detailed investigation of the site hydrology (tides and wave action), sediment grain size characteristics, and sediment hydraulic conductivity, and access for construction were assessed. It was determined that seabed gallery development is favorable at the site. Based on the seawater that has a salinity of about 41,000 mg/L and a conversion rate of 40%, a conservatively designed gallery cell with dimensions of 100 by 50 m would produce about 25,000 m3/day of filtered seawater and seven cells (6 primary and 1 standby) could support a 60,000 m3/day (permeate) seawater RO plant

  10. Comparing models of Red Knot population dynamics

    Science.gov (United States)

    McGowan, Conor P.

    2015-01-01

    Predictive population modeling contributes to our basic scientific understanding of population dynamics, but can also inform management decisions by evaluating alternative actions in virtual environments. Quantitative models mathematically reflect scientific hypotheses about how a system functions. In Delaware Bay, mid-Atlantic Coast, USA, to more effectively manage horseshoe crab (Limulus polyphemus) harvests and protect Red Knot (Calidris canutus rufa) populations, models are used to compare harvest actions and predict the impacts on crab and knot populations. Management has been chiefly driven by the core hypothesis that horseshoe crab egg abundance governs the survival and reproduction of migrating Red Knots that stopover in the Bay during spring migration. However, recently, hypotheses proposing that knot dynamics are governed by cyclical lemming dynamics garnered some support in data analyses. In this paper, I present alternative models of Red Knot population dynamics to reflect alternative hypotheses. Using 2 models with different lemming population cycle lengths and 2 models with different horseshoe crab effects, I project the knot population into the future under environmental stochasticity and parametric uncertainty with each model. I then compare each model's predictions to 10 yr of population monitoring from Delaware Bay. Using Bayes' theorem and model weight updating, models can accrue weight or support for one or another hypothesis of population dynamics. With 4 models of Red Knot population dynamics and only 10 yr of data, no hypothesis clearly predicted population count data better than another. The collapsed lemming cycle model performed best, accruing ~35% of the model weight, followed closely by the horseshoe crab egg abundance model, which accrued ~30% of the weight. The models that predicted no decline or stable populations (i.e. the 4-yr lemming cycle model and the weak horseshoe crab effect model) were the most weakly supported.

  11. KINGS Model: Achieving Sustainable Change in Nuclear Engineering Education for the Post-COP21 Era

    International Nuclear Information System (INIS)

    Oh, S.-K.

    2016-01-01

    Full text: In spite of the world nuclear community’s systematic and multilateral efforts during the COP21, most of the conference participants were reluctant to acknowledge the value of nuclear as a low-carbon energy source. In fact, the on-going aftermath of the Fukushima nuclear disaster has been overwhelming despite the evidence that there was neither any critical technical flaw nor fatal radiation casualties. This shows that advanced nuclear knowledge failed to resonate with public perception on nuclear energy. In this respect, it is now time to focus on achieving sustainable change in nuclear engineering education for the future. The KEPCO International Nuclear Graduate School (KINGS) was established to nurture leadership-level nuclear power professionals in the global standard. It affiliates with Korean nuclear industry to achieve three major goals that are also a universal prerequisite for higher education of engineering in the 21st century as follows: “a balance between education and training,” “harmony between engineering and managerial skills,” and “the application of systems engineering to nuclear power projects.” KINGS curriculum requires transdisciplinary coordination among engineering disciplines, engineering specialties, and socioeconomic methods. (author

  12. Comparative study of stability in different TCP/RED models

    International Nuclear Information System (INIS)

    Nga, J.H.C.; Iu, H.H.C.; Ling, S.H.; Lam, H.K.

    2008-01-01

    This paper studies the stability issue of the average queue length of a Transmission Control Protocol (TCP) model when interacting with Random Early Detection (RED). The model used for the study has shown period doubling bifurcation (PDB) and border collision bifurcation (BCB) in the average queue size at certain values of parameters when original RED is deployed. In this paper, we adopt a gentle version of RED and a newly derived RED algorithm into the model to study the improvement in stability of average queue size of the system

  13. Kings Today, Rich Tomorrow

    DEFF Research Database (Denmark)

    Fattoum, Asma

    2013-01-01

    This study investigates the King vs. Rich dilemma that founder-CEOs face at IPO. When undertaking IPO, founders face two options. They can either get rich, but then run the risk of losing the control over their firms; or they can remain kings by introducing defensive mechanisms, but this is likel...

  14. King Cove, Alaska 8 arc-second Coastal Digital Elevation Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA's National Geophysical Data Center (NGDC) is building high-resolution digital elevation models (DEMs) to support individual coastal States as part of the...

  15. King Cove, Alaska 8/15 arc-second Coastal Digital Elevation Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA's National Geophysical Data Center (NGDC) is building high-resolution digital elevation models (DEMs) to support individual coastal States as part of the...

  16. A Dynamic Energy Budget (DEB model to describe Laternula elliptica (King, 1832 seasonal feeding and metabolism.

    Directory of Open Access Journals (Sweden)

    Antonio Agüera

    Full Text Available Antarctic marine organisms are adapted to an extreme environment, characterized by a very low but stable temperature and a strong seasonality in food availability arousing from variations in day length. Ocean organisms are particularly vulnerable to global climate change with some regions being impacted by temperature increase and changes in primary production. Climate change also affects the biotic components of marine ecosystems and has an impact on the distribution and seasonal physiology of Antarctic marine organisms. Knowledge on the impact of climate change in key species is highly important because their performance affects ecosystem functioning. To predict the effects of climate change on marine ecosystems, a holistic understanding of the life history and physiology of Antarctic key species is urgently needed. DEB (Dynamic Energy Budget theory captures the metabolic processes of an organism through its entire life cycle as a function of temperature and food availability. The DEB model is a tool that can be used to model lifetime feeding, growth, reproduction, and their responses to changes in biotic and abiotic conditions. In this study, we estimate the DEB model parameters for the bivalve Laternula elliptica using literature-extracted and field data. The DEB model we present here aims at better understanding the biology of L. elliptica and its levels of adaptation to its habitat with a special focus on food seasonality. The model parameters describe a metabolism specifically adapted to low temperatures, with a low maintenance cost and a high capacity to uptake and mobilise energy, providing this organism with a level of energetic performance matching that of related species from temperate regions. It was also found that L. elliptica has a large energy reserve that allows enduring long periods of starvation. Additionally, we applied DEB parameters to time-series data on biological traits (organism condition, gonad growth to describe the

  17. An integrative appraisal of the hormonal and metabolic changes induced by acute stress using king penguins as a model.

    Science.gov (United States)

    Viblanc, Vincent A; Schull, Quentin; Cornioley, Tina; Stier, Antoine; Ménard, Jean-Jérôme; Groscolas, René; Robin, Jean-Patrice

    2017-08-23

    A large number of studies have focused on the reactivity of the hypothalamic-pituitaryadrenal (HPA) axis and the consequences of glucocorticoids (GC) in mediating life-history trade-offs. Although short-term increases in GCs are viewed as adaptive, mobilizing energy substrates allowing animals to deal with impending threats (e.g. stimulating hepatic gluconeogenesis, stimulating lipolysis, mobilizing amino acids), few studies have actually measured the exact time-course of substrate mobilisation in response to acute stress in natural conditions. We evaluated the hormonal and metabolic components of the stress response to acute stress in 32 free-living king penguins (Aptenodytes patagonicus). We monitored changes in blood GCs (corticosterone, CORT), glucose, lactate, ketone bodies (β-hydroxybutyrate), non-esterified fatty acids, and uric acid in response to a standardized capture-restraint protocol lasting for up to 90min. Furthermore, we tested whether the vigilance status of the animal (alert or asleep) affected its perception of the capture, thereby modulating the hormonal and metabolic stress responses. The time course of energy mobilisation followed the characteristic pattern expected from laboratory and theoretical models, with a rapid depletion of those energy stores linked to rapid adrenergic responses (i.e. glucose and ketone bodies), followed by a mobilisation of energy stores associated with the sustained longer-term GC response (i.e. fats and protein stores). HPA reactivity was generally slower than reported in other birds, and there was high inter-individual variability. Sleeping birds had higher GC and glucose responses to acute stress, suggesting a more rapid mobilization of energy stores. Our results highlight the importance of considering HPA and metabolic responses to acute stress against species-specific life history and ecological relevant backgrounds. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Red Storm usage model :Version 1.12.

    Energy Technology Data Exchange (ETDEWEB)

    Jefferson, Karen L.; Sturtevant, Judith E.

    2005-12-01

    Red Storm is an Advanced Simulation and Computing (ASC) funded massively parallel supercomputer located at Sandia National Laboratories (SNL). The Red Storm Usage Model (RSUM) documents the capabilities and the environment provided for the FY05 Tri-Lab Level II Limited Availability Red Storm User Environment Milestone and the FY05 SNL Level II Limited Availability Red Storm Platform Milestone. This document describes specific capabilities, tools, and procedures to support both local and remote users. The model is focused on the needs of the ASC user working in the secure computing environments at Los Alamos National Laboratory (LANL), Lawrence Livermore National Laboratory (LLNL), and SNL. Additionally, the Red Storm Usage Model maps the provided capabilities to the Tri-Lab ASC Computing Environment (ACE) requirements. The ACE requirements reflect the high performance computing requirements for the ASC community and have been updated in FY05 to reflect the community's needs. For each section of the RSUM, Appendix I maps the ACE requirements to the Limited Availability User Environment capabilities and includes a description of ACE requirements met and those requirements that are not met in that particular section. The Red Storm Usage Model, along with the ACE mappings, has been issued and vetted throughout the Tri-Lab community.

  19. Modelling the Seasonal Overturning Circulation in the Red Sea

    KAUST Repository

    Yao, Fengchao

    2015-04-01

    The overturning circulation in the Red Sea exhibits a distinct seasonally reversing pattern and is studied using 50-year, high-resolution MIT general circulation model simulations. The seasonal water exchange in the Strait of Bab el Mandeb is successfully simulated, and the structures of the intruding subsurface Gulf of Aden intermediate water are in good agreement with summer observations in 2011. The model results suggest that the summer overturning circulation is driven by the combined effect of the shoaling of the thermocline in the Gulf of Aden resulting from remote winds in the Arabian Sea and an upward surface slope from the Red Sea to the Gulf of Aden set up by local surface winds in the Red Sea. For the winter overturning circulation, the climatological model mean results suggest that the surface inflow intensifies in a western boundary current in the southern Red Sea that switches to an eastern boundary current north of 24°N. The overturning is accomplished through a cyclonic recirculation and a cross-basin overturning circulation in the northern Red Sea, with major sinking occurring along a narrow band of width about 20 km along the eastern boundary and weaker upwelling along the western boundary. The northward pressure gradient force, strong vertical mixing, and horizontal mixing near the boundary are the essential dynamical components in the model\\'s winter overturning circulation.

  20. Kings Today, Rich Tomorrow

    DEFF Research Database (Denmark)

    Fattoum, Asma

    2013-01-01

    This study investigates the King vs. Rich dilemma that founder-CEOs face at IPO. When undertaking IPO, founders face two options. They can either get rich, but then run the risk of losing the control over their firms; or they can remain kings by introducing defensive mechanisms, but this is likely...... to lead to lower IPO valuation. Using psychological ownership theory, we argue founder-CEOs to be more likely to choose the King option. This option forces them to leave money on the table at the IPO. However, their stewardship behavior allows them to recover that money on the long-run post IPO. We...... provide support for all hypotheses using a unique hand-collected dataset covering the full population of 467 IPOs undertaken in France between 1992 and 2011....

  1. King and Eye

    DEFF Research Database (Denmark)

    Suwannakij, Sing

    King and Eye explores the visual formation of kingship in Siam in its multifarious aspects. This dissertation identifies the leitmotifs in the dynamics between seeing the king and being seen by him, which burst forth in different eras. The visual sense has been a repository for the ontologization...... devices, most significantly the photographic and the cine cameras, but also encompassing other ocular apparatuses. The images produced through the contraptions were brought together under the royal eye at the apex, which in turn claimed its supremacy over space, time, and the vast and diverse population...

  2. Models for circumstellar nebulae around red and blue supergiants

    NARCIS (Netherlands)

    Chita, S.M.|info:eu-repo/dai/nl/304832146

    2011-01-01

    In this thesis, we model the circumstellar medium of stars with initial masses of 8, 12, 18 and 20 solar masses, over their entire life from the main sequence until their supernova explosion. During the post-main-sequence stages, stars can evolve through several blue and red supergiant stages

  3. Statistical modelling of fine red wine production

    Directory of Open Access Journals (Sweden)

    María Rosa Castro

    2010-01-01

    Full Text Available Producing wine is a very important economic activity in the province of San Juan in Argentina; it is therefore most important to predict production regarding the quantity of raw material needed. This work was aimed at obtaining a model relating kilograms of crushed grape to the litres of wine so produced. Such model will be used for predicting precise future values and confidence intervals for determined quantities of crushed grapes. Data from a vineyard in the province of San Juan was thus used in this work. The sampling coefficient of correlation was calculated and a dispersion diagram was then constructed; this indicated a li- neal relationship between the litres of wine obtained and the kilograms of crushed grape. Two lineal models were then adopted and variance analysis was carried out because the data came from normal populations having the same variance. The most appropriate model was obtained from this analysis; it was validated with experimental values, a good approach being obtained.

  4. The last Viking King

    DEFF Research Database (Denmark)

    Dissing, J.; Binladen, J.; Hansen, Anders J.

    2007-01-01

    The last of the Danish Viking Kings, Sven Estridsen, died in A.D. 1074 and is entombed in Roskilde Cathedral with other Danish viking kings and queens. Sven's mother, Estrid, is entombed in a pillar across the chancel. However, while there is no reasonable doubt about the identity of Sven......, there have been doubts among historians whether the woman entombed was indeed Estrid. To shed light on this problem, we have extracted and analysed mitochondrial DNA (mtDNA) from pulp of teeth from each of the two royals. Four overlapping DNA-fragments covering about 400 bp of hypervariable region 1 (HVR-1...... of rare cases where the sequence has been altered by a germ line mutation. Therefore, the observation of two sequence differences makes it highly unlikely that the entombed woman was the mother of Sven. In addition, physical examination of the skeleton and the teeth strongly indicated that this woman...

  5. Of Gods and Kings

    DEFF Research Database (Denmark)

    Brisch, Nicole

    2013-01-01

    throughout history. This is not a new point but remains all too often underappreciated when discussing the blurring of lines between human and god as evidenced in the deification of kings. In ancient Mesopotamia, one of the oldest high civilizations in the world, it was a short-lived but nevertheless......The idea that any living human being could be worshipped like a god may appear to some people unfathomable or sacrilegious. This is related to how the distinction between humans and god(s) is perceived in a given cultural context; divinity is a concept that has been understood very differently...... interesting phenomenon. The first instances of royal deification occur in the third millennium BCE during times of political expansion and centralization. Whether this worship continued into the second millennium BCE is still a matter of contention, yet Mesopotamian kings always maintained a close proximity...

  6. KFUPM-KAUST Red Sea model: Digital viscoelastic depth model and synthetic seismic data set

    KAUST Repository

    Al-Shuhail, Abdullatif A.

    2017-06-01

    The Red Sea is geologically interesting due to its unique structures and abundant mineral and petroleum resources, yet no digital geologic models or synthetic seismic data of the Red Sea are publicly available for testing algorithms to image and analyze the area\\'s interesting features. This study compiles a 2D viscoelastic model of the Red Sea and calculates a corresponding multicomponent synthetic seismic data set. The models and data sets are made publicly available for download. We hope this effort will encourage interested researchers to test their processing algorithms on this data set and model and share their results publicly as well.

  7. When physics became king

    CERN Document Server

    Morus, Iwan Rhys

    2005-01-01

    As recently as two hundred years ago, physics as we know it today did not exist. Born in the early nineteenth century during the second scientific revolution, physics struggled at first to achieve legitimacy in the scientific community and culture at large. In fact, the term "physicist" did not appear in English until the 1830s.When Physics Became King traces the emergence of this revolutionary science, demonstrating how a discipline that barely existed in 1800 came to be regarded a century later as the ultimate key to unlocking nature's secrets. A cultural history designed to provid

  8. Multiscale Modeling of Red Blood Cells Squeezing through Submicron Slits

    Science.gov (United States)

    Peng, Zhangli; Lu, Huijie

    2016-11-01

    A multiscale model is applied to study the dynamics of healthy red blood cells (RBCs), RBCs in hereditary spherocytosis, and sickle cell disease squeezing through submicron slits. This study is motivated by the mechanical filtration of RBCs by inter-endothelial slits in the spleen. First, the model is validated by comparing the simulation results with experiments. Secondly, the deformation of the cytoskeleton in healthy RBCs is investigated. Thirdly, the mechanisms of damage in hereditary spherocytosis are investigated. Finally, the effects of cytoplasm and membrane viscosities, especially in sickle cell disease, are examined. The simulations results provided guidance for future experiments to explore the dynamics of RBCs under extreme deformation.

  9. Halo Occupation Distribution Modeling of Clustering of Luminous Red Galaxies

    OpenAIRE

    Zheng, Zheng; Zehavi, Idit; Eisenstein, Daniel J.; Weinberg, David H.; Jing, Y. P.

    2008-01-01

    We perform Halo Occupation Distribution (HOD) modeling to interpret small-scale and intermediate-scale clustering of 35,000 luminous early-type galaxies and their cross-correlation with a reference imaging sample of normal L* galaxies in the Sloan Digital Sky Survey. The modeling results show that most of these luminous red galaxies (LRGs) are central galaxies residing in massive halos of typical mass M ~ a few times 10^13 to 10^14 Msun/h, while a few percent of them have to be satellites wit...

  10. Models for circumstellar nebulae around red and blue supergiants

    Science.gov (United States)

    Chita, S. M.

    2011-10-01

    In this thesis, we model the circumstellar medium of stars with initial masses of 8, 12, 18 and 20 solar masses, over their entire life from the main sequence until their supernova explosion. During the post-main-sequence stages, stars can evolve through several blue and red supergiant stages depending on their initial mass, composition and rotation rate. The models considered in the second Chapter have long-lasting RSG stages starting after the MS. In this phase, they develop shells of RSG wind material at the location where the free streaming RSG wind is stalled by the thermal pressure of the hot MS bubble, close to the central star. The RSG shells develop violent Rayleigh-Taylor instabilities. Once these start to grow non-linear, the RSG shell becomes highly structured as clumps form, and shell material mixes with material in the hot bubble. Later, the stars evolve to the BSG stage, during which the RSG shells are completely destroyed. These models return to the RSG stage, and build new RSG shells, which are more massive than those formed earlier. RSG shells are essential for our understanding of bipolar emission nebulae around BSGs. In the third Chapter are shown the results of the wind-wind interaction model of single star with 12 solar masses. On a time scale of a few 10000 yr, a BSG hour-glas shaped nebula expands into the sphere defined by the RSG shell. The faster polar parts of the hour glass hit the inner edge of the RSG shell first. The collision creates a pair of hot and dense polar caps. As time passes, the collision zone moves to lower latitudes of the RSG shell and becomes more confined in latitude. At the same time, the interaction of the BSG wind with the equatorial disk defines a second, ring shaped collision zone in the equatorial plane. These structures are reminiscent of the observed nebulae around the blue supergiant Sher 25. In the Chapter 3 we present calculations that predict the properties of the circumstellar medium for rapidly rotating

  11. Lion King Surveys Homeland

    Science.gov (United States)

    2004-01-01

    This image from the Mars Exploration Rover Opportunity's panoramic camera shows one octant of a larger panoramic image which has not yet been fully processed. The full panorama, dubbed 'Lion King' was obtained on sols 58 and 60 of the mission as the rover was perched at the lip of Eagle Crater, majestically looking down into its former home. It is the largest panorama yet obtained by either rover. The octant, which faces directly into the crater, shows features as small as a few millimeters across in the field near the rover arm, to features a few meters across or larger on the horizon. The full panoramic image was taken in eight segments using six filters per segment, for a total of 558 images and more than 75 megabytes of data. This enhanced color composite was assembled from the infrared (750 nanometer), green (530 nanometer), and violet (430 nanometer) filters. Additional lower elevation tiers were added relative to other panoramas to ensure that the entire crater was covered in the mosaic.

  12. King, Prof. Sir David Anthony

    Indian Academy of Sciences (India)

    Elected: 1998 Honorary. King, Prof. Sir David Anthony Sc.D., FRS. Date of birth: 12 August 1939. Address: Chief Scientific Adivser & Head, Office of Science and Innovation, London SW1H 0ET, U.K.. Contact: Office: (+44-020) 7215 3821. Fax: (+44-020) 7215 0314. Email: mpst.king@dti.gsi.gov.uk, dak10@cus.cam.ac.uk.

  13. Verification of the Hydrodynamic and Sediment Transport Hybrid Modeling System for Cumberland Sound and Kings Bay Navigation Channel, Georgia

    Science.gov (United States)

    1989-07-01

    different loca- tions and should not be directly evaluated. These data are provided for 72 8’ 0�PHSICAL MODEL 0*0NUMERICAL MODEL E HIGH WATER LE 6...TII. JM~ls a. Station 843 MIODEL. VERIFICATION - 1985 GEOMSETRY tt m •u - FIELD 61*110K le 4. a." -- 0 . 0 p-iOi" Plate \\1. is. in. 14. 1. Is. U. 94...STOTION 3n 4. a. L 0 MODE VEIICTO 195GOMTYw"" l -. L I 31 -6. 10. In. 14. 18. 18. a. *. 14. MIEL TIM. HMES a. Station 396 MI’ODEL VERIFICATION - 1985

  14. Exploring off-set pricing models and article deposit terms at King Abdullah University of Science & Technology (KAUST)

    KAUST Repository

    Buck, Stephen

    2018-04-09

    In the ‘normal’ world of retail and commerce you pay for an item and receive the item. In the world of academic journals you prepay for the item and you might receive the item and you might get some money back depending on what journals you did or didn’t receive. In the world of offset pricing you prepay, then you pay again, you sometimes use vouchers, you might get a discount (the following year) then you might get money back, or you might not. Are publishers knowingly placing barriers to off-set models, and not transparently offsetting the APCs to the subscription cost, in order to raise more income? Whether by design or accident it is a complex world which needs a time commitment, which not all librarians can give, to understand fully. The new model of scholarly communication, which leading universities (including KAUST) want to introduce, is based on shifting the subscription costs to publishing costs, not to double the payment channels to the publishers. Can we get to a mutually beneficial position where the author can deposit the accepted version of the article into the Institutional Repository without any embargo period as the institute is agreeing to pay the subscription fee on an ongoing basis? The required model does not adversely affect the vendors’ revenue. This presentation, based on KAUST’’s experience to date, will attempt to explain the different models of offset pricing while outlining KAUST’s dual approach, redirecting subscription money to publishing money and embedding open access terms in understandable language in our license agreements, to the problem. Why we have accepted IoP’s offset offer and not Springer’s, though we were considered among the first timers and important Institutions? Why is this important? Resolving the inherent complexities in offsetting models will save libraries money and also time wasted on tedious and unnecessary administration work. Researchers do not want to know about offsetting agreements nor

  15. MODELING THE VERY SMALL SCALE CLUSTERING OF LUMINOUS RED GALAXIES

    International Nuclear Information System (INIS)

    Watson, Douglas F.; Berlind, Andreas A.; McBride, Cameron K.; Masjedi, Morad

    2010-01-01

    We model the small-scale clustering of luminous red galaxies (LRGs) in the Sloan Digital Sky Survey. Specifically, we use the halo occupation distribution formalism to model the projected two-point correlation function of LRGs on scales well within the sizes of their host halos (0.016 h -1 Mpc ≤ r ≤ 0.42 h -1 Mpc). We start by varying P(N|M), the probability distribution that a dark matter halo of mass M contains N LRGs, and assuming that the radial distribution of satellite LRGs within halos traces the Navarro-Frenk-White (NFW) dark matter density profile. We find that varying P(N|M) alone is not sufficient to match the small-scale data. We next allow the concentration of satellite LRG galaxies to differ from that of dark matter and find that this is also not sufficient. Finally, we relax the assumption of an NFW profile and allow the inner slope of the density profile to vary. We find that this model provides a good fit to the data and the resulting value of the slope is -2.17 ± 0.12. The radial density profile of satellite LRGs within halos is thus not compatible with that of the underlying dark matter, but rather is closer to an isothermal distribution.

  16. A criticism of big bang cosmological models based on interpretation of the red shift

    Energy Technology Data Exchange (ETDEWEB)

    Kierein, J.W. (Ball Aerospace Systems Div., Boulder, CO (USA))

    1988-08-01

    The interaction of light with the intergalactic plasma produces the Hubble red shift versus distance relationship. This interaction also produces an isotopic long wavelength background radiation from the plasma. Intrinsic red shifts in quasars and other objects are similarly explained, showing why they are exceptions to Hubble's law. Because the red shift is not doppler-shifted, big bang cosmological models should be replaced with static models. (author).

  17. Congratulations to Carey King

    Science.gov (United States)

    Hall, Charles A. S.

    2012-03-01

    I first came across Carey King when, out of the blue, he invited me to a special session of the annual meeting of the American Association for the Advancement of Science (the largest and most prestigious US scientific meeting) where he was developing a special session on energy return on investment (EROI). At that meeting and since, I have found Carey to be a refreshing new colleague, extremely intelligent, very knowledgeable about many diverse aspects of energy and other things, able to take criticism and to dish it out, and very ambitious, which is mostly a good thing. He is becoming a leader in thinking about EROI and its implications, and I am delighted to see him honored by Environmental Research Letters. This is important because in the US, there is little insight about energy or, especially, its potential physical limitations except when gas prices increase. There is also little awareness of the very strong historical connection in both the US and the world between increased affluence and increased use of energy, especially petroleum. It is not understood by all that many of the economic problems we have now (such as the budgetary problems faced by most of our State governments, pension plans and universities) have substantial origin in the fact that oil and other energy production no longer increase reliably year after year, as they once did (Murphy and Hall 2011). Many economists have argued in the past that energy is not important because it constituted only 5 per cent or so of GDP, or because they believe that market forces and innovations will substitute for any shortage (e.g. Barnett and Morse 1963, Passell et al 1972, Solow 1974, Denison 1989). One problem with that view is that if you remove that five per cent the economy comes to a dead stop, as Cuba found out in 1989 when Russia removed its oil subsidy. Additionally if that five per cent goes up to 10 or 15 per cent, as it did in the early 1980s, and again in 2008, recession steps in (Murphy and

  18. Multi-year analysis of distributed glacier mass balance modelling and equilibrium line altitude on King George Island, Antarctic Peninsula

    Directory of Open Access Journals (Sweden)

    U. Falk

    2018-04-01

    Full Text Available The South Shetland Islands are located at the northern tip of the Antarctic Peninsula (AP. This region was subject to strong warming trends in the atmospheric surface layer. Surface air temperature increased about 3 K in 50 years, concurrent with retreating glacier fronts, an increase in melt areas, ice surface lowering and rapid break-up and disintegration of ice shelves. The positive trend in surface air temperature has currently come to a halt. Observed surface air temperature lapse rates show a high variability during winter months (standard deviations up to ±1.0 K (100 m−1 and a distinct spatial heterogeneity reflecting the impact of synoptic weather patterns. The increased mesocyclonic activity during the wintertime over the past decades in the study area results in intensified advection of warm, moist air with high temperatures and rain and leads to melt conditions on the ice cap, fixating surface air temperatures to the melting point. Its impact on winter accumulation results in the observed negative mass balance estimates. Six years of continuous glaciological measurements on mass balance stake transects as well as 5 years of climatological data time series are presented and a spatially distributed glacier energy balance melt model adapted and run based on these multi-year data sets. The glaciological surface mass balance model is generally in good agreement with observations, except for atmospheric conditions promoting snow drift by high wind speeds, turbulence-driven snow deposition and snow layer erosion by rain. No drift in the difference between simulated mass balance and mass balance measurements can be seen over the course of the 5-year model run period. The winter accumulation does not suffice to compensate for the high variability in summer ablation. The results are analysed to assess changes in meltwater input to the coastal waters, specific glacier mass balance and the equilibrium line altitude (ELA. The

  19. Modeling the Frequency of Cyclists’ Red-Light Running Behavior Using Bayesian PG Model and PLN Model

    Directory of Open Access Journals (Sweden)

    Yao Wu

    2016-01-01

    Full Text Available Red-light running behaviors of bicycles at signalized intersection lead to a large number of traffic conflicts and high collision potentials. The primary objective of this study is to model the cyclists’ red-light running frequency within the framework of Bayesian statistics. Data was collected at twenty-five approaches at seventeen signalized intersections. The Poisson-gamma (PG and Poisson-lognormal (PLN model were developed and compared. The models were validated using Bayesian p values based on posterior predictive checking indicators. It was found that the two models have a good fit of the observed cyclists’ red-light running frequency. Furthermore, the PLN model outperformed the PG model. The model estimated results showed that the amount of cyclists’ red-light running is significantly influenced by bicycle flow, conflict traffic flow, pedestrian signal type, vehicle speed, and e-bike rate. The validation result demonstrated the reliability of the PLN model. The research results can help transportation professionals to predict the expected amount of the cyclists’ red-light running and develop effective guidelines or policies to reduce red-light running frequency of bicycles at signalized intersections.

  20. Modelling larval dispersal of the king scallop ( Pecten maximus) in the English Channel: examples from the bay of Saint-Brieuc and the bay of Seine

    Science.gov (United States)

    Nicolle, Amandine; Dumas, Franck; Foveau, Aurélie; Foucher, Eric; Thiébaut, Eric

    2013-06-01

    The king scallop ( Pecten maximus) is one of the most important benthic species of the English Channel as it constitutes the first fishery in terms of landings in this area. To support strategies of spatial fishery management, we develop a high-resolution biophysical model to study scallop dispersal in two bays along the French coasts of the English Channel (i.e. the bay of Saint-Brieuc and the bay of Seine) and to quantify the relative roles of local hydrodynamic processes, temperature-dependent planktonic larval duration (PLD) and active swimming behaviour (SB). The two bays are chosen for three reasons: (1) the distribution of the scallop stocks in these areas is well known from annual scallop stock surveys, (2) these two bays harbour important fisheries and (3) scallops in these two areas present some differences in terms of reproductive cycle and spawning duration. The English Channel currents and temperature are simulated for 10 years (2000-2010) with the MARS-3D code and then used by the Lagrangian module of MARS-3D to model the transport. Results were analysed in terms of larval distribution at settlement and connectivity rates. While larval transport in the two bays depended both on the tidal residual circulation and the wind-induced currents, the relative role of these two hydrodynamic processes varied among bays. In the bay of Saint-Brieuc, the main patterns of larval dispersal were due to tides, the wind being only a source of variability in the extent of larval patch and the local retention rate. Conversely, in the bay of Seine, wind-induced currents altered both the direction and the extent of larval transport. The main effect of a variable PLD in relation to the thermal history of each larva was to reduce the spread of dispersal and consequently increase the local retention by about 10 % on average. Although swimming behaviour could influence larval dispersal during the first days of the PLD when larvae are mainly located in surface waters, it has a

  1. Using maximum entropy modeling to identify and prioritize red spruce forest habitat in West Virginia

    Science.gov (United States)

    Nathan R. Beane; James S. Rentch; Thomas M. Schuler

    2013-01-01

    Red spruce forests in West Virginia are found in island-like distributions at high elevations and provide essential habitat for the endangered Cheat Mountain salamander and the recently delisted Virginia northern flying squirrel. Therefore, it is important to identify restoration priorities of red spruce forests. Maximum entropy modeling was used to identify areas of...

  2. Views of Dr. Martin Luther King, Jr.

    Science.gov (United States)

    Davis, Alan H.

    1990-01-01

    Discusses views of Martin Luther King, Jr., including concepts of human rights, related counseling approaches, and ethics. Claims King's views provide helpful insights for counselors and clients. Concludes King invited individuals to view challenging life situations as moral opportunities. (Author/ABL)

  3. [King Injo's disease and burnt needle therapy].

    Science.gov (United States)

    Kim, In-Sook

    2004-12-01

    This paper investigates an interrelationship between burnt needle therapy and King Injo's disease. From 1633 (Year 11 in King Injo's reign) to May 5, 1649 (Year 27 in King Injo's reign), right before his death, King Injo was treated with burnt needles by Yi Hyeongik, an acupuncturist when the king had health problems. This study arises from two questions: why was King Injo often treated with burnt needles? and what effect did burnt needles have?Burnt needle therapy is a combined form of acupuncture and moxibustion. Yi Hyeongik was famous for eradicating pathogenic factors. He was appointed as a doctor in the Royal Hospital. The medical definition for pathogenic factors is that they are disease-causing factors. Understanding the pathogenic factor for King Injo's disease could make it possible to find the interrelationship between burnt needles and the king's disease. In the Joseon ear, the prevalent belief about diseases was that diseases could be caused by homeopathic magic. Some people thought homeopathic magic caused King Injo's disease. The actual reasons for King Injo's disease were the participation in the excessive rites of Queen Mother Inmok's funeral and the constant oppression from the Ching Dynasty after disgraceful defeat in the war. When King Injo started to be sick, homeopathic magic cases were found in the royal palace. The king's incurable disease was believed to have happened as a result of homeopathic magic. King Injo's suspicion toward Princess Jeongmyeong derived from her mother, Queen Mother Inmok. Moral justification for King Injo's coup was Gwanghaegun or Prince Gwanghae's immoral conduct toward Queen Mothe Inmok. After he was installed, King Injo obeyed the Queen Mother and showed her every attention. Meanwhile, he treated Princess Jeongmyeong with respect, maximized the moral justification for the coup, and solidified the royal authority. However, constant rebellions and treasons threatened King Injo. The king suspected that Queen Mother

  4. King Injo's Disease and Burnt Needle Therapy

    Directory of Open Access Journals (Sweden)

    KIM In-Sook

    2004-12-01

    Full Text Available This paper investigates an interrelationship between burnt needle therapy(번침 and King Injo'sdisease. From 1633 (Year 11 in King Injo's reign to May 5, 1649 (Year 27 King in Injo's reign, right before his death, King Injo(인조 was treated with burnt needles by Yi Hyeongik(이형익, an acupuncturist when the king had health problems. This study arises from two questions: why was King Injo often treated with burnt needles? and what effect did burnt needles have? Burnt needle therapy is a combined form of acupuncture and moxibustion. Yi Hyeongik was famous for eradicating pathogenic factors. He was appointed as a doctor in the Royal Hospital. The medical definition for pathogenic factors is that they are disease-causing factors. Understanding the pathogenic factor for King Injo's disease could make it possible to find the interrelationship between burnt needles and the king's disease. In the Joseon era, the prevalent belief about diseases was that diseases could be caused by homeopathic magic. Some people thought homeopathic magic caused King Injo's disease.  The actual reasons for King Injo's disease were the participation in the excessive rites of Queen Mother Inmok's funeral and the constant oppression from the Ching Dynasty after disgraceful defeat in the war. When King Injo started to be sick, homeopathic magic cases were found in the royal palace. The king's incurable disease was believed to have happened as a result of homeopathic magic. King Injo's suspicion toward Princess Jeongmyeong(정명공주 derived from her mother, Queen Mother Inmok(인목대비. Moral justification for King Injo's coup was Gwanghaegun(광해군 or Prince Gwanghae's immoral conduct toward Queen Mother Inmok. After he was installed, King Injo obeyed the Queen Mother and showed her every attention. Meanwhile, he treated Princess Jeongmyeong with respect, maximized the moral justification for the coup, and solidified the royal authority. However, constant

  5. 78 FR 21914 - North Pacific Fishery Management Council (NPFMC); Public Meeting

    Science.gov (United States)

    2013-04-12

    ...), Norton Sound Red King Crab (NSRKC), Pribilof Island Golden King Crab (PIGKC), Adak red king crab. Model update and reviews for Snow Crab, Tanner Crab, Saint Matthew Blue King Crab, Bristol Bay Red King Crab...

  6. Opportunity Captures 'Lion King' Panorama

    Science.gov (United States)

    2004-01-01

    [figure removed for brevity, see original site] Click on the image for Opportunity Captures 'Lion King' Panorama (QTVR) This approximate true-color panorama, dubbed 'Lion King,' shows 'Eagle Crater' and the surrounding plains of Meridiani Planum. It was obtained by the Mars Exploration Rover Opportunity's panoramic camera on sols 58 and 60 using infrared (750-nanometer), green (530-nanometer) and blue (430-nanometer) filters. This is the largest panorama obtained yet by either rover. It was taken in eight segments using six filters per segment, for a total of 558 images and more than 75 megabytes of data. Additional lower elevation tiers were added to ensure that the entire crater was covered in the mosaic. This panorama depicts a story of exploration including the rover's lander, a thorough examination of the outcrop, a study of the soils at the near-side of the lander, a successful exit from Eagle Crater and finally the rover's next desination, the large crater dubbed 'Endurance'.

  7. Precision Measurements of the Cluster Red Sequence using an Error Corrected Gaussian Mixture Model

    Energy Technology Data Exchange (ETDEWEB)

    Hao, Jiangang; /Fermilab /Michigan U.; Koester, Benjamin P.; /Chicago U.; Mckay, Timothy A.; /Michigan U.; Rykoff, Eli S.; /UC, Santa Barbara; Rozo, Eduardo; /Ohio State U.; Evrard, August; /Michigan U.; Annis, James; /Fermilab; Becker, Matthew; /Chicago U.; Busha, Michael; /KIPAC, Menlo Park /SLAC; Gerdes, David; /Michigan U.; Johnston, David E.; /Northwestern U. /Brookhaven

    2009-07-01

    The red sequence is an important feature of galaxy clusters and plays a crucial role in optical cluster detection. Measurement of the slope and scatter of the red sequence are affected both by selection of red sequence galaxies and measurement errors. In this paper, we describe a new error corrected Gaussian Mixture Model for red sequence galaxy identification. Using this technique, we can remove the effects of measurement error and extract unbiased information about the intrinsic properties of the red sequence. We use this method to select red sequence galaxies in each of the 13,823 clusters in the maxBCG catalog, and measure the red sequence ridgeline location and scatter of each. These measurements provide precise constraints on the variation of the average red galaxy populations in the observed frame with redshift. We find that the scatter of the red sequence ridgeline increases mildly with redshift, and that the slope decreases with redshift. We also observe that the slope does not strongly depend on cluster richness. Using similar methods, we show that this behavior is mirrored in a spectroscopic sample of field galaxies, further emphasizing that ridgeline properties are independent of environment. These precise measurements serve as an important observational check on simulations and mock galaxy catalogs. The observed trends in the slope and scatter of the red sequence ridgeline with redshift are clues to possible intrinsic evolution of the cluster red-sequence itself. Most importantly, the methods presented in this work lay the groundwork for further improvements in optically-based cluster cosmology.

  8. Exploring the Red Sea seasonal ecosystem functioning using a three-dimensional biophysical model

    KAUST Repository

    Triantafyllou, G.

    2014-03-01

    The Red Sea exhibits complex hydrodynamic and biogeochemical dynamics, which vary both in time and space. These dynamics have been explored through the development and application of a 3-D ecosystem model. The simulation system comprises two off-line coupled submodels: the MIT General Circulation Model (MITgcm) and the European Regional Seas Ecosystem Model (ERSEM), both adapted for the Red Sea. The results from an annual simulation under climatological forcing are presented. Simulation results are in good agreement with satellite and in situ data illustrating the role of the physical processes in determining the evolution and variability of the Red Sea ecosystem. The model was able to reproduce the main features of the Red Sea ecosystem functioning, including the exchange with the Gulf of Aden, which is a major driving mechanism for the whole Red Sea ecosystem and the winter overturning taking place in the north. Some model limitations, mainly related to the dynamics of the extended reef system located in the southern part of the Red Sea, which is not currently represented in the model, still need to be addressed.

  9. Climatic features of the Red Sea from a regional assimilative model

    KAUST Repository

    Viswanadhapalli, Yesubabu

    2016-08-16

    The Advanced Research version of Weather Research and Forecasting (WRF-ARW) model was used to generate a downscaled, 10-km resolution regional climate dataset over the Red Sea and adjacent region. The model simulations are performed based on two, two-way nested domains of 30- and 10-km resolutions assimilating all conventional observations using a cyclic three-dimensional variational approach over an initial 12-h period. The improved initial conditions are then used to generate regional climate products for the following 24 h. We combined the resulting daily 24-h datasets to construct a 15-year Red Sea atmospheric downscaled product from 2000 to 2014. This 15-year downscaled dataset is evaluated via comparisons with various in situ and gridded datasets. Our analysis indicates that the assimilated model successfully reproduced the spatial and temporal variability of temperature, wind, rainfall, relative humidity and sea level pressure over the Red Sea region. The model also efficiently simulated the seasonal and monthly variability of wind patterns, the Red Sea Convergence Zone and associated rainfall. Our results suggest that dynamical downscaling and assimilation of available observations improve the representation of regional atmospheric features over the Red Sea compared to global analysis data from the National Centers for Environmental Prediction. We use the dataset to describe the atmospheric climatic conditions over the Red Sea region. © 2016 Royal Meteorological Society.

  10. The King Tapestries at Kronborg Castle

    DEFF Research Database (Denmark)

    Reindel, Ulrik

    2015-01-01

    In the 1580s, Frederik II (Danish-Norwegian king, reigned 1559-1588) had the Great Hall at Kronborg Castle, Elsinore, furnished with 43 tapestries portraying no fewer than 100 Danish kings. The tapestries were arranged chronologically, beginning with King Dan, the mythological founder of the king...... in the backgrounds, and more or less fancifully conceived coats of arms, the tapestry series provided «historical» evidence justifying the rising political ambitions of Frederik II....... Frederik II’s case in his ongoing diplomatic disputes with the neighbouring kingdom of Sweden and staging the Danish-Norwegian king as a key protagonist of the protestant movement. By combining the portraits of – mostly legendary – kings with pretentious monologues, symbolic or emblematic details dispersed...

  11. Modelling of Red Giant Stars: The state-of-the-art

    Directory of Open Access Journals (Sweden)

    Cassisi Santi

    2017-01-01

    Full Text Available The seismic data obtained by the CoRoT and Kepler space missions have provided inferences of the global and structural properties of thousands of red giants. When compared with stellar model predictions, these inferences can significantly improve our understanding of stellar evolution. We present a brief review of the structure and evolution of red giant stars, devoting some emphasis on the major, still open problems.

  12. Construction of Spectral Discoloration Model for Red Lead Pigment by Aging Test and Simulating Degradation Experiment

    Directory of Open Access Journals (Sweden)

    Jinxing Liang

    2016-01-01

    Full Text Available The construction of spectral discoloration model, based on aging test and simulating degradation experiment, was proposed to detect the aging degree of red lead pigment in ancient murals and to reproduce the spectral data supporting digital restoration of the ancient murals. The degradation process of red lead pigment under the aging test conditions was revealed by X-ray diffraction, scanning electron microscopy, and spectrophotometer. The simulating degradation experiment was carried out by proportionally mixing red lead and lead dioxide with referring to the results of aging test. The experimental result indicated that the pure red lead was gradually turned into black lead dioxide, and the amount of tiny particles of the aging sample increased faced with aging process. Both the chroma and lightness of red lead pigment decreased with discoloration, and its hue essentially remains unchanged. In addition, the spectral reflectance curves of the aging samples almost started rising at about 550 nm with the inflection moving slightly from about 570 nm to 550 nm. The spectral reflectance of samples in long- and in short-wavelength regions was fitted well with the logarithmic and linear function. The spectral discoloration model was established, and the real aging red lead pigment in Dunhuang murals was measured and verified the effectiveness of the model.

  13. Nile Red Staining for Oil Determination in Microalgal Cells: A New Insight through Statistical Modelling

    Directory of Open Access Journals (Sweden)

    Ronald Halim

    2015-01-01

    Full Text Available In the wake of global warming and rapid fossil fuel depletion, microalgae emerge as promising feedstocks for sustainable biofuel production. Nile red staining acts as a rapid diagnostic tool to measure the amount of biodiesel-convertible lipid that the cells accumulate. There is a need for the development of a more uniform staining procedure. In its first phase, this study examined the dependence of microalgal Nile red fluorescence (Tetraselmis suecica in terms of its most pertinent staining variables. A quadratic surface model that successfully described the Nile red fluorescence intensity as a composite function of its variables was generated (r2=0.86. Cell concentration was shown to have a significant effect on the fluorescence intensity. Up to a certain threshold, fluorescence intensity was shown to increase with Nile red dye concentration. In its second phase, the study reviewed findings from previous Nile red studies to elucidate some of the fundamental mechanism underlying the diffusion of Nile red dye molecules into the microalgal cells and their subsequent interaction with intracellular lipids. Through the review process, we were able to develop a simple framework that provided a set of guidelines for the standardization of the Nile red staining procedure across different microalgal species.

  14. Cardioprotective effects of red wine and vodka in a model of endothelial dysfunction.

    Science.gov (United States)

    Lassaletta, Antonio D; Chu, Louis M; Elmadhun, Nassrene Y; Burgess, Thomas A; Feng, Jun; Robich, Michael P; Sellke, Frank W

    2012-12-01

    Moderate alcohol consumption is largely believed to be cardioprotective, while red wine is hypothesized to offer benefit in part due to the proangiogenic and antioxidant properties of polyphenols. We investigated the cardiovascular effects of both red wine and vodka in a swine model of endothelial dysfunction. Twenty-seven male Yorkshire swine fed a high-fat/cholesterol diet were divided into three groups and received either no alcohol (Control), red wine, or vodka. After 7 wk, myocardial perfusion was measured, and ventricular tissue was analyzed for microvascular reactivity and immunohistochemical studies. There were no differences in myocardial perfusion, in arteriolar or capillary density, or in VEGF expression among groups. Total protein oxidation as well as expression of superoxide dismutase-1 and -2 and NADPH oxidase was decreased in both treatment groups compared to controls. Endothelium-dependent microvessel relaxation, however, was significantly improved only in the red wine-supplemented group. Supplementation with both red wine and vodka decreased oxidative stress by several measures, implicating the effects of ethanol in reducing oxidative stress in the myocardium. However, it was only in the red wine-supplemented group that an improvement in microvessel function was observed. This suggests that a component of red wine, independent of ethanol, possibly a polyphenol such as resveratrol, may confer cardioprotection by normalizing endothelial dysfunction induced by an atherogenic diet. Copyright © 2012 Elsevier Inc. All rights reserved.

  15. The Words of Martin Luther King, Jr.

    Science.gov (United States)

    Today's Education, 1979

    1979-01-01

    Excerpts from speeches by Dr. Martin Luther King, Jr., are reprinted. Topics discussed include discrimination, the South, education, nonviolent resistance, poverty, economic opportunity, and world peace. (LH)

  16. Towards the best approach for wind wave modelling in the Red Sea

    KAUST Repository

    Langodan, Sabique

    2015-04-01

    While wind and wave modelling is nowadays quite satisfactory in the open oceans, problems are still present in the enclosed seas. In general, the smaller the basin, the poorer the models perform, especially if the basin is surrounded by a complex orography. The Red Sea is an extreme example in this respect, especially because of its long and narrow shape. This deceivingly simple domain offers very interesting challenges for wind and wave modeling, not easily, if ever, found elsewhere. Depending on the season, opposite wind regimes, one directed to southeast, the other one to northwest, are present and may coexist in the most northerly and southerly parts of the Red Sea. Where the two regimes meet, the wave spectra can be rather complicated and, crucially dependent on small details of the driving wind fields. We explored how well we could reproduce the general and unusual wind and wave patterns of the Red Sea using different meteorological products. Best results were obtained using two rather opposite approaches: the high-resolution Weather Research Forecasting (WRF) regional model and the slightly enhanced surface winds from the global European Centre for Medium-Range Weather Forecasts (ECMWF) model. We discuss the reasons why these two approaches produce the best results and the implications on wave modeling in the Red Sea. The unusual wind and wave patterns in the Red Sea suggest that the currently available wave model source functions may not properly represent the evolution of local fields. However, within limits, the WAVEWATCH III wave model, based on Janssen\\'s and also Ardhuin\\'s wave model physics, provides in many cases very reasonable results. Because surface winds lead to important uncertainties in wave simulation, we also discuss the impact of data assimilation for simulating the most accurate winds, and consequently waves, over the Red Sea.

  17. Image-based model of the spectrin cytoskeleton for red blood cell simulation

    Science.gov (United States)

    Stokes, David L.; Peskin, Charles S.

    2017-01-01

    We simulate deformable red blood cells in the microcirculation using the immersed boundary method with a cytoskeletal model that incorporates structural details revealed by tomographic images. The elasticity of red blood cells is known to be supplied by both their lipid bilayer membranes, which resist bending and local changes in area, and their cytoskeletons, which resist in-plane shear. The cytoskeleton consists of spectrin tetramers that are tethered to the lipid bilayer by ankyrin and by actin-based junctional complexes. We model the cytoskeleton as a random geometric graph, with nodes corresponding to junctional complexes and with edges corresponding to spectrin tetramers such that the edge lengths are given by the end-to-end distances between nodes. The statistical properties of this graph are based on distributions gathered from three-dimensional tomographic images of the cytoskeleton by a segmentation algorithm. We show that the elastic response of our model cytoskeleton, in which the spectrin polymers are treated as entropic springs, is in good agreement with the experimentally measured shear modulus. By simulating red blood cells in flow with the immersed boundary method, we compare this discrete cytoskeletal model to an existing continuum model and predict the extent to which dynamic spectrin network connectivity can protect against failure in the case of a red cell subjected to an applied strain. The methods presented here could form the basis of disease- and patient-specific computational studies of hereditary diseases affecting the red cell cytoskeleton. PMID:28991926

  18. Multispecies modeling for adaptive management of horseshoe crabs and red knots in the Delaware Bay

    Science.gov (United States)

    McGowan, Conor P.; Smith, David; Sweka, John A.; Martin, Julien; Nichols, James D.; Wong, Richard; Lyons, James E.; Niles, Lawrence J.; Kalasz, Kevin; Brust, Jeffrey; Klopfer, Michelle; Spear, Braddock

    2011-01-01

    Adaptive management requires that predictive models be explicit and transparent to improve decisions by comparing management actions, directing further research and monitoring, and facilitating learning. The rufa subspecies of red knots (Calidris canutus rufa), which has recently exhibited steep population declines, relies on horseshoe crab (Limulus polyphemus) eggs as their primary food source during stopover in Delaware Bay during spring migration. We present a model with two different parameterizations for use in the adaptive management of horseshoe crab harvests in the Delaware Bay that links red knot mass gain, annual survival, and fecundity to horseshoe crab dynamics. The models reflect prevailing hypotheses regarding ecological links between these two species. When reported crab harvest from 1998 to 2008 was applied, projections corresponded to the observed red knot population abundances depending on strengths of the demographic relationship between these species. We compared different simulated horseshoe crab harvest strategies to evaluate whether, given this model, horseshoe crab harvest management can affect red knot conservation and found that restricting harvest can benefit red knot populations. Our model is the first to explicitly and quantitatively link these two species and will be used within an adaptive management framework to manage the Delaware Bay system and learn more about the specific nature of the linkage between the two species.

  19. Image-based model of the spectrin cytoskeleton for red blood cell simulation.

    Science.gov (United States)

    Fai, Thomas G; Leo-Macias, Alejandra; Stokes, David L; Peskin, Charles S

    2017-10-01

    We simulate deformable red blood cells in the microcirculation using the immersed boundary method with a cytoskeletal model that incorporates structural details revealed by tomographic images. The elasticity of red blood cells is known to be supplied by both their lipid bilayer membranes, which resist bending and local changes in area, and their cytoskeletons, which resist in-plane shear. The cytoskeleton consists of spectrin tetramers that are tethered to the lipid bilayer by ankyrin and by actin-based junctional complexes. We model the cytoskeleton as a random geometric graph, with nodes corresponding to junctional complexes and with edges corresponding to spectrin tetramers such that the edge lengths are given by the end-to-end distances between nodes. The statistical properties of this graph are based on distributions gathered from three-dimensional tomographic images of the cytoskeleton by a segmentation algorithm. We show that the elastic response of our model cytoskeleton, in which the spectrin polymers are treated as entropic springs, is in good agreement with the experimentally measured shear modulus. By simulating red blood cells in flow with the immersed boundary method, we compare this discrete cytoskeletal model to an existing continuum model and predict the extent to which dynamic spectrin network connectivity can protect against failure in the case of a red cell subjected to an applied strain. The methods presented here could form the basis of disease- and patient-specific computational studies of hereditary diseases affecting the red cell cytoskeleton.

  20. The Red Sea: An Arena for Wind-Wave Modeling in Enclosed Seas

    KAUST Repository

    Langodan, Sabique

    2016-12-01

    Wind and waves play a major role in important ocean dynamical processes, such as the exchange of heat, momentum and gases between atmosphere and ocean, that greatly contributes to the earth climate and marine lives. Knowledge on wind and wave weather and climate is crucial for a wide range of applications, including oceanographic studies, maritime activities and ocean engineering. Despite being one of the important world shipping routes, the wind-wave characteristics in the Red Sea are yet to be fully explored. Because of the scarcity of waves data in the Red Sea, numerical models become crucial and provide very powerful tools to extrapolate wind and wave data in space, and backward and forward in time. Unlike open oceans, enclosed basins wave have different characteristics, mainly because of their local generation processes. The complex orography on both sides of the Red Sea makes the local wind, and consequently wave, modeling very challenging. This thesis considers the modeling of wind-wave characteristics in the Red Sea, including their climate variability and trends using state-of-the-art numerical models and all available observations. Different approaches are investigated to model and understand the general and unusual wind and wave conditions in the basin using standard global meteorological products and customised regional wind and wave models. After studying and identifying the main characteristics of the wind-wave variability in the Red Sea, we demonstrate the importance of generating accurate atmospheric forcing through data assimilation for reliable wave simulations. In particular, we show that the state-of-the-art physical formulation of wave models is not suitable to model the unique situation of the two opposing wind-waves systems in the Red Sea Convergence Zone, and propose and successfully test a modification to the input and white-capping source functions to address this problem. We further investigate the climate variability and trends of wind

  1. The Red Sea: A Natural Laboratory for Wind and Wave Modeling

    KAUST Repository

    Langodan, Sabique

    2014-12-01

    The Red Sea is a narrow, elongated basin that is more than 2000km long. This deceivingly simple structure offers very interesting challenges for wind and wave modeling, not easily, if ever, found elsewhere. Using standard meteorological products and local wind and wave models, this study explores how well the general and unusual wind and wave patterns of the Red Sea could be reproduced. The authors obtain the best results using two rather opposite approaches: the high-resolution Weather Research Forecasting (WRF) local model and the slightly enhanced surface winds from the global European Centre for Medium-Range Weather Forecasts model. The reasons why these two approaches produce the best results and the implications on wave modeling in the Red Sea are discussed. The unusual wind and wave patterns in the Red Sea suggest that the currently available wave model source functions may not properly represent the evolution of local fields. However, within limits, the WAVEWATCH III wave model, based on Janssen\\'s and also Ardhuin\\'s wave model physics, provides very reasonable results in many cases. The authors also discuss these findings and outline related future work.

  2. The King's Ring: A Matter of Trust

    DEFF Research Database (Denmark)

    Sterrett, Joseph William

    2018-01-01

    This essay examines the material and social effects of an exchange of trust between a king, Henry VIII, and his counsellor, Thomas Cranmer in Shakespeare and Fletcher’s All is True. The ring that the King gives Cranmer is both nothing and everything: nothing in that it could be anything, any ring...

  3. Population dynamics of king eiders breeding in northern Alaska

    Science.gov (United States)

    Bentzen, Rebecca L.; Powell, Abby N.

    2012-01-01

    The North American population of king eiders (Somateria spectabilis) has declined by more than 50% since the late 1970s for unknown reasons. King eiders spend most of their lives in remote areas, forcing managers to make regulatory and conservation decisions based on very little information. We incorporated available published estimates of vital rates with new estimates to build a female, stage-based matrix population model for king eiders and examine the processes underlying population dynamics of king eiders breeding at 2 sites, Teshekpuk and Kuparuk, on the coastal plain of northern Alaska and wintering around the Bering Sea (2001–2010). We predicted a decreasing population (λ = 0.981, 95% CI: 0.978–0.985), and that population growth was most sensitive to changes in adult female survival (sensitivity = 0.92). Low duckling survival may be a bottleneck to productivity (variation in ducking survival accounted for 66% of retrospective variation in λ). Adult survival was high (0.94) and invariant (σ = 0.0002, 95% CI: 0.0000–0.0007); however, catastrophic events could have a major impact and we need to consider how to mitigate and manage threats to adult survival. A hypothetical oil spill affecting breeding females in a primary spring staging area resulted in a severe population decline; although, transient population dynamics were relatively stable. However, if no catastrophic events occur, the more variable reproductive parameters (duckling and nest survival) may be more responsive to management actions.

  4. Modeling and Recovery of Iron (Fe) from Red Mud by Coal Reduction

    Science.gov (United States)

    Zhao, Xiancong; Li, Hongxu; Wang, Lei; Zhang, Lifeng

    Recovery of Fe from red mud has been studied using statistically designed experiments. The effects of three factors, namely: reduction temperature, reduction time and proportion of additive on recovery of Fe have been investigated. Experiments have been carried out using orthogonal central composite design and factorial design methods. A model has been obtained through variance analysis at 92.5% confidence level.

  5. Statistical Modeling Studies of Iron Recovery from Red Mud Using Thermal Plasma

    Science.gov (United States)

    Swagat, S. Rath; Archana, Pany; Jayasankar, K.; Ajit, K. Mitra; C. Satish, Kumar; Partha, S. Mukherjee; Barada, K. Mishra

    2013-05-01

    Optimization studies of plasma smelting of red mud were carried out. Reduction of the dried red mud fines was done in an extended arc plasma reactor to recover the pig iron. Lime grit and low ash metallurgical (LAM) coke were used as the flux and reductant, respectively. 2-level factorial design was used to study the influence of all parameters on the responses. Response surface modeling was done with the data obtained from statistically designed experiments. Metal recovery at optimum parameters was found to be 79.52%.

  6. Modeling of Regional Climate over Red Sea and Arabian Peninsula

    KAUST Repository

    Stenchikov, Georgiy L.

    2011-04-09

    Observations, re-analyses, and climate model simulations show strong surface temperature trends in Middle East and Arabian Peninsula in the last 30 years. Trends are especially pronounced in summer exceeding +1K/decade. However, some regions, e.g., the So

  7. Seasonal overturning circulation in the Red Sea: 1. Model validation and summer circulation

    KAUST Repository

    Yao, Fengchao

    2014-04-01

    The overturning circulation in the Red Sea exhibits a distinct seasonally reversing pattern and is studied using high-resolution MIT general circulation model simulations. In the first part of this study, the vertical and horizontal structure of the summer overturning circulation and its dynamical mechanisms are presented from the model results. The seasonal water exchange in the Strait of Bab el Mandeb is successfully simulated, and the structures of the intruding subsurface Gulf of Aden intermediate water are in good agreement with summer observations in 2011. The model results suggest that the summer overturning circulation is driven by the combined effect of the shoaling of the thermocline in the Gulf of Aden resulting from remote winds in the Arabian Sea and an upward surface slope from the Red Sea to the Gulf of Aden set up by local surface winds in the Red Sea. In addition, during late summer two processes associated, respectively, with latitudinally differential heating and increased salinity in the southern Red Sea act together to cause the reversal of the contrast of the vertical density structure and the cessation of the summer overturning circulation. Dynamically, the subsurface northward pressure gradient force is mainly balanced by vertical viscosity resulting from the vertical shear and boundary friction in the Strait of Bab el Mandeb. Unlike some previous studies, the three-layer summer exchange flows in the Strait of Bab el Mandeb do not appear to be hydraulically controlled.

  8. The Red Queen model of recombination hot-spot evolution: a theoretical investigation.

    Science.gov (United States)

    Latrille, Thibault; Duret, Laurent; Lartillot, Nicolas

    2017-12-19

    In humans and many other species, recombination events cluster in narrow and short-lived hot spots distributed across the genome, whose location is determined by the Zn-finger protein PRDM9. To explain these fast evolutionary dynamics, an intra-genomic Red Queen model has been proposed, based on the interplay between two antagonistic forces: biased gene conversion, mediated by double-strand breaks, resulting in hot-spot extinction, followed by positive selection favouring new PRDM9 alleles recognizing new sequence motifs. Thus far, however, this Red Queen model has not been formalized as a quantitative population-genetic model, fully accounting for the intricate interplay between biased gene conversion, mutation, selection, demography and genetic diversity at the PRDM9 locus. Here, we explore the population genetics of the Red Queen model of recombination. A Wright-Fisher simulator was implemented, allowing exploration of the behaviour of the model (mean equilibrium recombination rate, diversity at the PRDM9 locus or turnover rate) as a function of the parameters (effective population size, mutation and erosion rates). In a second step, analytical results based on self-consistent mean-field approximations were derived, reproducing the scaling relations observed in the simulations. Empirical fit of the model to current data from the mouse suggests both a high mutation rate at PRDM9 and strong biased gene conversion on its targets.This article is part of the themed issue 'Evolutionary causes and consequences of recombination rate variation in sexual organisms'. © 2017 The Authors.

  9. Transcranial red and near infrared light transmission in a cadaveric model.

    Directory of Open Access Journals (Sweden)

    Jared R Jagdeo

    Full Text Available BACKGROUND AND OBJECTIVE: Low level light therapy has garnered significant interest within the past decade. The exact molecular mechanisms of how red and near infrared light result in physiologic modulation are not fully understood. Heme moieties and copper within cells are red and near infrared light photoreceptors that induce the mitochondrial respiratory chain component cytochrome C oxidase, resulting in a cascade linked to cytoprotection and cellular metabolism. The copper centers in cytochrome C oxidase have a broad absorption range that peaks around 830 nm. Several in vitro and in vivo animal and human models exist that have demonstrated the benefits of red light and near infrared light for various conditions. Clinical applications for low level light therapy are varied. One study in particular demonstrated improved durable functional outcomes status post-stroke in patients treated with near infrared low level light therapy compared to sham treatment [1]. Despite previous data suggesting the beneficial effect in treating multiple conditions, including stroke, with low level light therapy, limited data exists that measures transmission in a human model. STUDY DESIGN/MATERIALS AND METHODS: To investigate this idea, we measured the transmission of near infrared light energy, using red light for purposes of comparison, through intact cadaver soft tissue, skull bones, and brain using a commercially available LED device at 830 nm and 633 nm. RESULTS: Our results demonstrate that near infrared measurably penetrates soft tissue, bone and brain parenchyma in the formalin preserved cadaveric model, in comparison to negligible red light transmission in the same conditions. CONCLUSION: These findings indicate that near infrared light can penetrate formalin fixed soft tissue, bone and brain and implicate that benefits observed in clinical studies are potentially related to direct action of near infrared light on neural tissue.

  10. King Chulalongkorn: biography and his activities in medicine and public health.

    Science.gov (United States)

    Charulukananan, Somrat; Sueblinvong, Tada

    2003-06-01

    King Rama V, or Chulalongkorn, was the fifth monarch of the Chakri Dynasty. He was one of the most beloved of the Thai kings due to his many activities including abolishing slavery without bloodshed and especially his skillful diplomacy which succeeded in steering Siam out of the grips of the colonial powers. His activities also included reform of the administration of the kingdom according to the European model and in bringing Siam into the modern era with such exquisite skills that he is still vividly remembered today. His reign also saw many developments in medicine and public health. The King's role in these areas, however, were clouded by his more visible activities in politics and diplomacy. The result is that the Thai public learned rather little about his role in these areas. This article aims at collecting this and to show the King's very important role in modernizing medicine and public health in Siam.

  11. [King Jung-jo's medical philosophy].

    Science.gov (United States)

    Kim, Sun Hyung; Kim, Dal Rae

    2009-12-01

    King Jungjo who introduced the advent of cultural renaissance of Chosun Dynasty as little been known about his work in medicine. With a wide knowledge in medicine, he was the only one among the kings who wrote a book on medicine, called "SueMinMyoJeon". In this paper, his perspective on medicine will be looked into based on "The Annals of the Chosun Dynasty", "Seungjeongwon Ilgi", "Hong Je jun Se", "KukGoBoGam", "Ildkrok", "JeJungShinPyun", "SueMinMyoJeon" etc. King Jungo valued empiricism in the field of medicine. He deepened understandings in medicine while taking care of King Youngjo, the late king. And it led him to author "SueMinMyoJeon" himself, and further ordered the publications of "JeJungShinPyun" "MaGuaHeoiTong". These two books were conducted to include empirical cases of folklore remedy. King Jungjo's medical philosophy can be epitomized in filial piety and realization of people-serving politics, which are the essentials of Confucianism. His filial piety towards the late king, Youngjo and his mother is shown in his devotion when taking care of them. Especially the way he examined the differentiation of diseases and corresponding treatments is well described in "The Annals of the Chosun Dynasty". "JeJungShinPyun" was also published and it came handy for folk villagers in times of medical needs. Later this book influenced "BangYakHaepPyun" by Hwang Do Yeon. King Jungjo emphasized pragmatism in spreading medical knowledges, thus removing the theoretical contents that are related to Taoism, especially the ones on alchemy from "DongEuiBoGam", when publishing "SueMinMyoJeon". Even the excerpts from "SoMun" were taken out, if not practical. King Jungjo, however, discussed the importance of healthy regimen and mentioned himself practicing it from the book "IlDeukLok", which seems to be the only book that derailed from the pragmatistic track. King Jungjo put emphasis on consistency between diagnosis and treatment. In diagnosing, Meridian pulse was taken

  12. Deformation of Two-Dimensional Nonuniform-Membrane Red Blood Cells Simulated by a Lattice Boltzmann Model

    International Nuclear Information System (INIS)

    Hua-Bing, Li; Li, Jin; Bing, Qiu

    2008-01-01

    To study two-dimensional red blood cells deforming in a shear Bow with the membrane nonuniform on the rigidity and mass, the membrane is discretized into equilength segments. The fluid inside and outside the red blood cell is simulated by the D2Q9 lattice Boltzmann model and the hydrodynamic forces exerted on the membrane from the inner and outer of the red blood cell are calculated by a stress-integration method. Through the global deviation from the curvature of uniform-membrane, we find that when the membrane is nonuniform on the rigidity, the deviation first decreases with the time increases and implies that the terminal profile of the red blood cell is static. To a red blood cell with the mass nonuniform on the membrane, the deviation becomes more large, and the mass distribution affects the profile of the two sides of the flattened red blood cell in a shear flow. (fundamental areas of phenomenology(including applications))

  13. Pharmacodynamic model of interleukin-21 effects on red blood cells in cynomolgus monkeys

    DEFF Research Database (Denmark)

    Overgaard, Rune Viig; Karlsson, M.; Ingwersen, S.H.

    2007-01-01

    of treatment. The present analysis investigates the observed pharmacodynamics effects on red blood cells following various treatment schedules of human IL-21 administrated to cynomolgus monkeys. These effects are described by a novel non-linear mixed-effects model that enabled separation of drug effects...... that the structural model presented here can be used for other types of drug induced loss of red blood cells, whereas the mechanism for sampling related blood loss is relevant for investigations of anaemia in all pharmacological studies with smaller animals.......Interleukin-21 (IL-21) is a novel cytokine that is currently under clinical investigations as a potential anti-cancer agent. Like many other anti-cancer agents, including other interleukins, IL-21 is seen to produce a broad range of biological effects that may be related to both efficacy and safety...

  14. Modeling Kepler Observations of Solar-like Oscillations in the Red Giant Star HD 186355

    DEFF Research Database (Denmark)

    Jiang, C.; Jiang, B.W.; Christensen-Dalsgaard, Jørgen

    2011-01-01

    comparisons between observational constraints and models. A number of mixed l = 1 modes are also detected and taken into account in our model comparisons. We find a mean observational period spacing for these mixed modes of about 58 s, suggesting that this red giant branch star is in the shell hydrogen......We have analyzed oscillations of the red giant star HD 186355 observed by the NASA Kepler satellite. The data consist of the first five quarters of science operations of Kepler, which cover about 13 months. The high-precision time-series data allow us to accurately extract the oscillation...... frequencies from the power spectrum. We find that the frequency of the maximum oscillation power, νmax, and the mean large frequency separation, Δν, are around 106 and 9.4 μHz, respectively. A regular pattern of radial and non-radial oscillation modes is identified by stacking the power spectra in an echelle...

  15. John Davies of Hereford, the King of Denmark & Shakespeare's Meeting of Kings: Praise Beyond Praise

    DEFF Research Database (Denmark)

    Sterrett, Joseph William

    2016-01-01

    This article traces the response and style of John Davies of Hereford, 'an ordinary man' as he celebrated an extraordinary event, the state visit of the King of Denmark to the court of James I in 1606. It then draws comparisons to Shakespeare's meeting of kings some seven or eight years later...

  16. Red jungle fowl (Gallus gallus) as a model for studying the molecular mechanism of seasonal reproduction.

    Science.gov (United States)

    Ono, Hiroko; Nakao, Nobuhiro; Yamamura, Takashi; Kinoshita, Keiji; Mizutani, Makoto; Namikawa, Takao; Iigo, Masayuki; Ebihara, Shizufumi; Yoshimura, Takashi

    2009-06-01

    Photoperiodism is an adaptation mechanism that enables animals to predict seasonal changes in the environment. Japanese quail is the best model organism for studying photoperiodism. Although the recent availability of chicken genome sequences has permitted the expansion from single gene to genome-wide transcriptional analysis in this organism, the photoperiodic response of the domestic chicken is less robust than that of the quail. Therefore, in the present study, we examined the photoperiodic response of the red jungle fowl (Gallus gallus), a predecessor of the domestic chicken, to test whether this animal could be developed as an ideal model for studying the molecular mechanisms of seasonal reproduction. When red jungle fowls were transferred from short-day- to long-day conditions, gonadal development and an increase in plasma LH concentration were observed. Furthermore, rapid induction of thyrotropin beta subunit, a master regulator of photoperiodism, was observed at 16 h after dawn on the first long day. In addition, the long-day condition induced the expression of type 2 deiodinase, the key output gene of photoperiodism. These results were consistent with the results obtained in quail and suggest that the red jungle fowl could be an ideal model animal for the genome-wide transcriptional analysis of photoperiodism.

  17. Strategies for nest-site selection by king eiders

    Science.gov (United States)

    Bentzen, R.L.; Powell, A.N.; Suydam, R.S.

    2009-01-01

    Nest site selection is a critical component of reproduction and has presumably evolved in relation to predation, local resources, and microclimate. We investigated nest-site choice by king eiders (Somateria spectabilis) on the coastal plain of northern Alaska, USA, 2003-2005. We hypothesized that nest-site selection is driven by predator avoidance and that a variety of strategies including concealment, seclusion, and conspecific or inter-specific nest defense might lead to improved nesting success. We systematically searched wetland basins for king eider nests and measured habitat and social variables at nests (n = 212) and random locations (n = 493). King eiders made use of both secluded and concealed breeding strategies; logistic regression models revealed that females selected nests close to water, on islands, and in areas with high willow (Salix spp.) cover but did not select sites near conspecific or glaucous gull (Larus hyperboreus) nests. The most effective nest-placement strategy may vary depending on density and types of nest predators; seclusion is likely a mammalian-predator avoidance tactic whereas concealment may provide protection from avian predators. We recommend that managers in northern Alaska attempt to maintain wetland basins with islands and complex shorelines to provide potential nest sites in the vicinity of water. ?? The Wildlife Society.

  18. Data and Dynamics Driven Approaches for Modelling and Forecasting the Red Sea Chlorophyll

    KAUST Repository

    Dreano, Denis

    2017-05-31

    Phytoplankton is at the basis of the marine food chain and therefore play a fundamental role in the ocean ecosystem. However, the large-scale phytoplankton dynamics of the Red Sea are not well understood yet, mainly due to the lack of historical in situ measurements. As a result, our knowledge in this area relies mostly on remotely-sensed observations and large-scale numerical marine ecosystem models. Models are very useful to identify the mechanisms driving the variations in chlorophyll concentration and have practical applications for fisheries operation and harmful algae blooms monitoring. Modelling approaches can be divided between physics- driven (dynamical) approaches, and data-driven (statistical) approaches. Dynamical models are based on a set of differential equations representing the transfer of energy and matter between different subsets of the biota, whereas statistical models identify relationships between variables based on statistical relations within the available data. The goal of this thesis is to develop, implement and test novel dynamical and statistical modelling approaches for studying and forecasting the variability of chlorophyll concentration in the Red Sea. These new models are evaluated in term of their ability to efficiently forecast and explain the regional chlorophyll variability. We also propose innovative synergistic strategies to combine data- and physics-driven approaches to further enhance chlorophyll forecasting capabilities and efficiency.

  19. Effectiveness of Instructional Design Model (Isman - 2011) in Developing the Planning Teaching Skills of Teachers College Students' at King Saud University

    Science.gov (United States)

    Isman, Aytekin; Abanmy, Fahad AbdulAziz; Hussein, Hisham Barakat; Al Saadany, Mohammed Abdurrahman

    2012-01-01

    The new instructional design model (Isman - 2011) aims at planing, developing, implementing, evaluating, and organizing full learning activities effectively to ensure competent performance by students. The theoretical foundation of this model comes from behaviorism, cognitivism and constructivism views. And it's based on active learning. During…

  20. A rabbit model of hypersensitivity to plicatic acid, the agent responsible for red cedar asthma.

    Science.gov (United States)

    Chan, H; Tse, K S; Van Oostdam, J; Moreno, R; Pare, P D; Chan-Yeung, M

    1987-05-01

    We describe a rabbit model for the study of the immunogenicity and allergenicity of plicatic acid (PA), the small molecular weight compound in western red cedar responsible for occupational asthma in exposed workers. Specific anti-PA IgE as well as IgG antibodies could be raised, depending on the method of immunization. The sensitized rabbits reacted to antigenic challenge with PA-protein conjugates intravenously, with increases in respiratory frequency and pulmonary resistance. This animal model may be used for the further elucidation of the mechanism of occupational asthma induced by small molecular weight chemical compounds.

  1. NOAA Office for Coastal Management Coastal Inundation Digital Elevation Model: Seattle (WA) WFO - Whatcom, San Juan, Skagit, Island, Snohomish, and King Counties

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This digital elevation model (DEM) is a part of a series of DEMs produced for the National Oceanic and Atmospheric Administration Office for Coastal Management's Sea...

  2. A mean field model for competition: from neutral ecology to the Red Queen.

    Science.gov (United States)

    O'Dwyer, James P; Chisholm, Ryan

    2014-08-01

    Individual species are distributed inhomogeneously over space and time, yet, within large communities of species, aggregated patterns of biodiversity seem to display nearly universal behaviour. Neutral models assume that an individual's demographic prospects are independent of its species identity. They have successfully predicted certain static, time-independent patterns. But they have generally failed to predict temporal patterns, such as species ages or population dynamics. We construct a new, multispecies framework incorporating competitive differences between species, and assess the impact of this competition on static and dynamic patterns of biodiversity. We solve this model exactly for the special case of a Red Queen hypothesis, where fitter species are continually arising. The model predicts more realistic species ages than neutral models, without greatly changing predictions for static species abundance distributions. Our modelling approach may allow users to incorporate a broad range of ecological mechanisms. © 2014 John Wiley & Sons Ltd/CNRS.

  3. Joint coevolutionary-epidemiological models dampen Red Queen cycles and alter conditions for epidemics.

    Science.gov (United States)

    MacPherson, Ailene; Otto, Sarah P

    2017-12-28

    Host-parasite interactions in the form of infectious diseases are a topic of interest in both evolutionary biology and public health. Both fields have relied on mathematical models to predict and understand the dynamics and consequences of these interactions. Yet few models explicitly incorporate both epidemiological and coevolutionary dynamics, allowing for genetic variation in both hosts and parasites. By comparing a matching-alleles model of coevolution, a susceptible-infected-recovered-susceptible compartmental model from epidemiology, and a combined coevolutionary-epidemiology model we assess the effect of the coevolutionary feedback on the epidemiological dynamics and vice versa. We find that Red-Queen cycles are not robust in an epidemiological framework and that coevolutionary interactions can alter the conditions under which epidemic cycles arise. Incorporating both explicit epidemiology and genetic diversity may have important implications for the maintenance of sexual reproduction as well as disease management. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Modeling a typical winter-time dust event over the Arabian Peninsula and the Red Sea

    KAUST Repository

    Kalenderski, Stoitchko

    2013-02-20

    We used WRF-Chem, a regional meteorological model coupled with an aerosol-chemistry component, to simulate various aspects of the dust phenomena over the Arabian Peninsula and Red Sea during a typical winter-time dust event that occurred in January 2009. The model predicted that the total amount of emitted dust was 18.3 Tg for the entire dust outburst period and that the two maximum daily rates were ?2.4 Tg day-1 and ?1.5 Tg day-1, corresponding to two periods with the highest aerosol optical depth that were well captured by ground-and satellite-based observations. The model predicted that the dust plume was thick, extensive, and mixed in a deep boundary layer at an altitude of 3-4 km. Its spatial distribution was modeled to be consistent with typical spatial patterns of dust emissions. We utilized MODIS-Aqua and Solar Village AERONET measurements of the aerosol optical depth (AOD) to evaluate the radiative impact of aerosols. Our results clearly indicated that the presence of dust particles in the atmosphere caused a significant reduction in the amount of solar radiation reaching the surface during the dust event. We also found that dust aerosols have significant impact on the energy and nutrient balances of the Red Sea. Our results showed that the simulated cooling under the dust plume reached 100 W m-2, which could have profound effects on both the sea surface temperature and circulation. Further analysis of dust generation and its spatial and temporal variability is extremely important for future projections and for better understanding of the climate and ecological history of the Red Sea.

  5. Modeling a typical winter-time dust event over the Arabian Peninsula and the Red Sea

    Directory of Open Access Journals (Sweden)

    S. Kalenderski

    2013-02-01

    Full Text Available We used WRF-Chem, a regional meteorological model coupled with an aerosol-chemistry component, to simulate various aspects of the dust phenomena over the Arabian Peninsula and Red Sea during a typical winter-time dust event that occurred in January 2009. The model predicted that the total amount of emitted dust was 18.3 Tg for the entire dust outburst period and that the two maximum daily rates were ~2.4 Tg day−1 and ~1.5 Tg day−1, corresponding to two periods with the highest aerosol optical depth that were well captured by ground- and satellite-based observations. The model predicted that the dust plume was thick, extensive, and mixed in a deep boundary layer at an altitude of 3–4 km. Its spatial distribution was modeled to be consistent with typical spatial patterns of dust emissions. We utilized MODIS-Aqua and Solar Village AERONET measurements of the aerosol optical depth (AOD to evaluate the radiative impact of aerosols. Our results clearly indicated that the presence of dust particles in the atmosphere caused a significant reduction in the amount of solar radiation reaching the surface during the dust event. We also found that dust aerosols have significant impact on the energy and nutrient balances of the Red Sea. Our results showed that the simulated cooling under the dust plume reached 100 W m−2, which could have profound effects on both the sea surface temperature and circulation. Further analysis of dust generation and its spatial and temporal variability is extremely important for future projections and for better understanding of the climate and ecological history of the Red Sea.

  6. Red ginseng powder fermented with probiotics exerts antidiabetic effects in the streptozotocin-induced mouse diabetes model.

    Science.gov (United States)

    Jang, Sun-Hee; Park, Jisang; Kim, Sae-Hae; Choi, Kyung-Min; Ko, Eun-Sil; Cha, Jeong-Dan; Lee, Young-Ran; Jang, Hyonseok; Jang, Yong-Suk

    2017-12-01

    Red ginseng (heat-processed Panax ginseng) is a well-known alternative medicine with pharmacological antidiabetic activity. It exerts pharmacological effects through the transformation of saponin into metabolites by the intestinal microbiota. Given that intestinal conditions and intestinal microflora vary among individuals, the pharmacological effects of orally administered red ginseng likely may vary among individuals. To overcome this variation and produce homogeneously effective red ginseng, we evaluated the antidiabetic effects of probiotic-fermented red ginseng in a mouse model. The antidiabetic efficacy of orally administered probiotic-fermented red ginseng was assessed in ICR mice after induction of diabetes using streptozotocin (170 mg/kg body weight). Samples were given orally for 8 weeks, and indicators involved in diabetic disorders such as body weight change, water intake, blood glucose, glucose tolerance and various biochemical parameters were determined. Oral administration of probiotic-fermented red ginseng significantly decreased the level of blood glucose of about 62.5% in the fasting state and induced a significant increase in glucose tolerance of about 10.2% compared to the control diabetic mice. Additionally, various indicators of diabetes and biochemical data (e.g., blood glycosylated haemoglobin level, serum concentrations of insulin, and α-amylase activity) showed a significant improvement in the diabetic conditions of the mice treated with probiotic-fermented red ginseng in comparison with those of control diabetic mice. Our results demonstrate the antidiabetic effects of probiotic-fermented red ginseng in the streptozotocin-induced mouse diabetes model and suggest that probiotic-fermented red ginseng may be a uniformly effective red ginseng product.

  7. Modelling Kepler red giants in eclipsing binaries: calibrating the mixing-length parameter with asteroseismology

    Science.gov (United States)

    Li, Tanda; Bedding, Timothy R.; Huber, Daniel; Ball, Warrick H.; Stello, Dennis; Murphy, Simon J.; Bland-Hawthorn, Joss

    2018-03-01

    Stellar models rely on a number of free parameters. High-quality observations of eclipsing binary stars observed by Kepler offer a great opportunity to calibrate model parameters for evolved stars. Our study focuses on six Kepler red giants with the goal of calibrating the mixing-length parameter of convection as well as the asteroseismic surface term in models. We introduce a new method to improve the identification of oscillation modes that exploits theoretical frequencies to guide the mode identification (`peak-bagging') stage of the data analysis. Our results indicate that the convective mixing-length parameter (α) is ≈14 per cent larger for red giants than for the Sun, in agreement with recent results from modelling the APOGEE stars. We found that the asteroseismic surface term (i.e. the frequency offset between the observed and predicted modes) correlates with stellar parameters (Teff, log g) and the mixing-length parameter. This frequency offset generally decreases as giants evolve. The two coefficients a-1 and a3 for the inverse and cubic terms that have been used to describe the surface term correction are found to correlate linearly. The effect of the surface term is also seen in the p-g mixed modes; however, established methods for correcting the effect are not able to properly correct the g-dominated modes in late evolved stars.

  8. Habitability of super-Earth planets around other suns: models including Red Giant Branch evolution.

    Science.gov (United States)

    von Bloh, W; Cuntz, M; Schröder, K-P; Bounama, C; Franck, S

    2009-01-01

    The unexpected diversity of exoplanets includes a growing number of super-Earth planets, i.e., exoplanets with masses of up to several Earth masses and a similar chemical and mineralogical composition as Earth. We present a thermal evolution model for a 10 Earth-mass planet orbiting a star like the Sun. Our model is based on the integrated system approach, which describes the photosynthetic biomass production and takes into account a variety of climatological, biogeochemical, and geodynamical processes. This allows us to identify a so-called photosynthesis-sustaining habitable zone (pHZ), as determined by the limits of biological productivity on the planetary surface. Our model considers solar evolution during the main-sequence stage and along the Red Giant Branch as described by the most recent solar model. We obtain a large set of solutions consistent with the principal possibility of life. The highest likelihood of habitability is found for "water worlds." Only mass-rich water worlds are able to realize pHZ-type habitability beyond the stellar main sequence on the Red Giant Branch.

  9. Sidewalk data in King County's urban growth boundary.

    Science.gov (United States)

    2013-06-01

    This report describes the development of geospatial sidewalk data for the King County Urban : Growth Area. Prior to the development of this data set, sidewalk data in King County were limited to : select jurisdictions and existed in multiple, sometim...

  10. The city of the divine king

    DEFF Research Database (Denmark)

    Barnow, Niels Finn

    2001-01-01

    The City of the Divine King deals with urban systems and urban architecture in the river kingdoms of the Near East and the agrarian societies of the Orient. The book is part of a larger work comprising studies of the antique Greek world and the Roman Empire and the later developments of cities an...

  11. Tribute to Julie Taymor's Lion King Costumes

    Science.gov (United States)

    Carter, Mary C.; Beaty, Ben

    2011-01-01

    Julie Taymor's costumes and masks for the stage version of "The Lion King" were stunning in the way they combined the dual images of human and animal forms. Taymor visually incorporated the human form of a dancer into the simplified form of the animal character so both are equally visible. This visible duality of human form and animal…

  12. "King Corn": Teaching the Food Crisis

    Science.gov (United States)

    Swinehart, Tim

    2012-01-01

    "King Corn" is in so many ways the story of how government food policy has entirely remade the food landscape in the United States over the last 40 years. From the massive expansion of the number of acres of corn grown across the country, to the ever-increasing ways that corn is incorporated into the food production process, to the…

  13. Kings Covered Bridge rehabilitation, Somerset County, PA

    Science.gov (United States)

    William J. Collins; David C. Fischetti; Arnold M. Jr. Graton; Len Lichvar; Branden Diehl; James P. Wacker; Ed Cesa; Ed Stoltz; Emory L. Kemp; Samer H. Petro; Leon Buckwalter; John McNamara

    2005-01-01

    Kings Covered Bridge over Laurel Creek in Somerset County, Pennsylvania is approximately 114-foot clear span multiple Kingpost Truss with nail-laminated arches. This timber bridge is historically significant because it retains its original features of the 1860’s since the 1930s when it was spared from modernization by the construction of an adjacent steel highway...

  14. Anogeissus sericea var. nummalaria King ex Duthie

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 4. Anogeissus sericea var. nummalaria King ex Duthie. Flowering Trees Volume 8 Issue 4 April 2003 pp 89-89. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/008/04/0089-0089. Resonance ...

  15. The city of the divine king

    DEFF Research Database (Denmark)

    Barnow, Niels Finn

    2001-01-01

    The City of the Divine King deals with urban systems and urban architecture in the river kingdoms of the Near East and the agrarian societies of the Orient. The book is part of a larger work comprising studies of the antique Greek world and the Roman Empire and the later developments of cities...

  16. Briti publik armastab King Kongi / Andris Feldmanis

    Index Scriptorium Estoniae

    Feldmanis, Andris, 1982-

    2006-01-01

    Briti filmiajakiri Empire lugejate filmiauhinnad : parim film "King Kong" (Peter Jackson), parim režii Steve Box, Nick Park "Wallace & Gromit - libaküüliku needus", parim meesnäitleja Johnny Depp, parim naisnäitleja Thandie Newton

  17. Population status and habitat associations of the King Rail in the midwestern United States

    Science.gov (United States)

    Bolenbaugh, Jason R.; Cooper, Tom; Brady, Ryan S.; Willard, Karen L.; Krementz, David G.

    2012-01-01

    The migratory population of the King Rail (Rallus elegans) has declined dramatically during the past 50 years, emphasizing the need to document the distribution and status of this species to help guide conservation efforts. In an effort to guide King Rail breeding habitat protection and restoration, a landscape suitability index (LSI) model was developed for the Upper Mississippi River and Great Lakes Region Joint Venture (JV). To validate this model, 264 sites were surveyed across the JV region in 2008 and 2009 using the National Marshbird Monitoring protocol. Two other similarly collected data sets from Wisconsin (250 sites) and Ohio (259 sites) as well as data from the Cornell Laboratory of Ornithology's eBird database were added to our data set. Sampling effort was not uniform across the study area. King Rails were detected at 29 sites with the greatest concentration in southeastern Wisconsin and northeastern Illinois. Too few detections were made to validate the LSI model. King Rail detection sites tended to have microtopographic heterogeneity, more emergent herbaceous wetland vegetation and less woody vegetation. The migrant population of the King Rail is rare and warrants additional conservation efforts to achieve stated conservation population targets.

  18. Xanthinuria in a family of Cavalier King Charles spaniels

    NARCIS (Netherlands)

    vanZuilen, CD; Nickel, RF; vanDijk, TH; Reijngoud, DJ

    1997-01-01

    Xanthine calculi mere found in a 7-month-old male Cavalier King Charles spaniel with urethral obstruction and renal insufficiency, Because the only two other reported cases of naturally occurring xanthine urolithiasis concerned a Cavalier King Charles and a King Charles spaniel the urine of the

  19. The Newest Monument: The Martin Luther King, Jr. National Memorial

    Science.gov (United States)

    Social Studies and the Young Learner, 2011

    2011-01-01

    This article features the newest monument, the Martin Luther King, Jr. National Memorial. The memorial on the National Mall in Washington, D.C., honoring Dr. Martin Luther King, Jr. will be an engaging landscape experience to convey four fundamental and recurring themes throughout Dr. King's life--democracy, justice, hope, and love. Natural…

  20. 76 FR 3819 - Martin Luther King, Jr., Federal Holiday, 2011

    Science.gov (United States)

    2011-01-20

    ... changed the course of history. The Reverend Dr. Martin Luther King, Jr. devoted his life to the struggle... freedom and the security of justice.'' On Martin Luther King, Jr., Federal Holiday, we commemorate the... Martin Luther King, Jr., Federal Holiday. I encourage all Americans to observe this day with appropriate...

  1. Differences between selection on sex versus recombination in red queen models with diploid hosts.

    Science.gov (United States)

    Agrawal, Aneil F

    2009-08-01

    The Red Queen hypothesis argues that parasites generate selection for genetic mixing (sex and recombination) in their hosts. A number of recent papers have examined this hypothesis using models with haploid hosts. In these haploid models, sex and recombination are selectively equivalent. However, sex and recombination are not equivalent in diploids because selection on sex depends on the consequences of segregation as well as recombination. Here I compare how parasites select on modifiers of sexual reproduction and modifiers of recombination rate. Across a wide set of parameters, parasites tend to select against both sex and recombination, though recombination is favored more often than is sex. There is little correspondence between the conditions favoring sex and those favoring recombination, indicating that the direction of selection on sex is often determined by the effects of segregation, not recombination. Moreover, when sex was favored it is usually due to a long-term advantage whereas short-term effects are often responsible for selection favoring recombination. These results strongly indicate that Red Queen models focusing exclusively on the effects of recombination cannot be used to infer the type of selection on sex that is generated by parasites on diploid hosts.

  2. On the Crossover of Boundary Currents in an Idealized Model of the Red Sea

    KAUST Repository

    Zhai, Ping

    2015-05-01

    © 2015 American Meteorological Society. The west-to-east crossover of boundary currents has been seen in mean circulation schemes from several past models of the Red Sea. This study investigates the mechanisms that produce and control the crossover in an idealized, eddy-resolving numerical model of the Red Sea. The authors also review the observational evidence and derive an analytical estimate for the crossover latitude. The surface buoyancy loss increases northward in the idealized model, and the resultant mean circulation consists of an anticyclonic gyre in the south and a cyclonic gyre in the north. In the midbasin, the northward surface flow crosses from the western boundary to the eastern boundary. Numerical experiments with different parameters indicate that the crossover latitude of the boundary currents changes with f0, β, and the meridional gradient of surface buoyancy forcing. In the analytical estimate, which is based on quasigeostrophic, β-plane dynamics, the crossover is predicted to lie at the latitude where the net potential vorticity advection (including an eddy component) is zero. Various terms in the potential vorticity budget can be estimated using a buoyancy budget, a thermal wind balance, and a parameterization of baroclinic instability.

  3. Two-Dimensional Computational Flow Analysis and Frictional Characteristics Model for Red Blood Cell under Inclined Centrifuge Microscopy

    Science.gov (United States)

    Funamoto, Kenichi; Hayase, Toshiyuki; Shirai, Atsushi

    Simplified two-dimensional flow analysis is performed in order to simulate frictional characteristics measurement of red blood cells moving on a glass plate in a medium with an inclined centrifuge microscope. Computation under various conditions reveals the influences of parameters on lift, drag, and moment acting on a red blood cell. Among these forces, lift appears only when the cell is longitudinally asymmetric. By considering the balance of forces, the frictional characteristics of the red blood cell are modeled as the sum of Coulomb friction and viscous drag. The model describes the possibility that the red blood cell deforms to expand in the front side in response to the inclined centrifugal force. When velocity exceeds some critical value, the lift overcomes the normal centrifugal force component, and the thickness of the plasma layer between the cell and the glass plate increases from the initial value of the plasma protein thickness.

  4. A possibly universal red chromophore for modeling color variations on Jupiter

    Science.gov (United States)

    Sromovsky, L. A.; Baines, K. H.; Fry, P. M.; Carlson, R. W.

    2017-07-01

    A new laboratory-generated chemical compound made from photodissociated ammonia (NH3) molecules reacting with acetylene (C2H2) was suggested as a possible coloring agent for Jupiter's Great Red Spot (GRS) by Carlson et al. (2016, Icarus 274, 106-115). Baines et al. (2016, Icarus, submitted) showed that the GRS spectrum measured by the visual channels of the Cassini VIMS instrument in 2000 could be accurately fit by a cloud model in which the chromophore appeared as a physically thin layer of small particles immediately above the main cloud layer of the GRS. Here we show that the same chromophore and same layer location can also provide close matches to the short wavelength spectra of many other cloud features on Jupiter, suggesting this material may be a nearly universal chromophore that could explain the various degrees of red coloration on Jupiter. This is a robust conclusion, even for 12% changes in VIMS calibration and large uncertainties in the refractive index of the main cloud layer due to uncertain fractions of NH4SH and NH3 in its cloud particles. The chromophore layer can account for color variations among north and south equatorial belts, equatorial zone, and the Great Red Spot, by varying particle size from 0.12 μm to 0.29 μm and 1-μm optical depth from 0.06 to 0.76. The total mass of the chromophore layer is much less variable, ranging from 18 to 30 μg/cm2, except in the equatorial zone, where it is only 10-13 μg/cm2. We also found a depression of the ammonia volume mixing ratio in the two belt regions, which averaged 0.4 - 0.5 ×10-4 immediately below the ammonia condensation level, while the other regions averaged twice that value.

  5. Photostability of Natural Orange-Red and Yellow Fungal Pigments in Liquid Food Model Systems

    DEFF Research Database (Denmark)

    Mapari, Sameer Shamsuddin; Meyer, Anne S.; Thrane, Ulf

    2009-01-01

    an enhanced photostability of fungal pigment extracts compared to the commercially available natural colorants Monascus Red and turmeric used as controls. Yellow components of the orange-red fungal pigment extract were more photostable than the red components. Chemistry of the photodegradation of the orange...

  6. The current distribution, predictive modeling, and restoration potential of red spruce in West Virginia

    Science.gov (United States)

    Gregory Nowacki; Dan. Wendt

    2010-01-01

    The environmental relationships of red spruce (Picea rubens Sarg.) were assessed in east-central West Virginia. Although many significant relationships existed, red spruce was most strongly associated with elevation, climate, and soil moisture factors. Specifically, red spruce was positively associated with elevation, number of frost days, mean...

  7. An extended convection diffusion model for red blood cell-enhanced transport of thrombocytes and leukocytes

    Energy Technology Data Exchange (ETDEWEB)

    Hund, S J; Antaki, J F [Carnegie Mellon University, 700 Technology Dr., CMRI/PTC 4218, Pittsburgh, PA 15219 (United States)], E-mail: shund@andrew.cmu.edu, E-mail: antaki@andrew.cmu.edu

    2009-10-21

    Transport phenomena of platelets and white blood cells (WBCs) are fundamental to the processes of vascular disease and thrombosis. Unfortunately, the dilute volume occupied by these cells is not amenable to fluid-continuum modeling, and yet the cell count is large enough that modeling each individual cell is impractical for most applications. The most feasible option is to treat them as dilute species governed by convection and diffusion; however, this is further complicated by the role of the red blood cell (RBC) phase on the transport of these cells. We therefore propose an extended convection-diffusion (ECD) model based on the diffusive balance of a fictitious field potential, {psi}, that accounts for the gradients of both the dilute phase and the local hematocrit. The ECD model was applied to the flow of blood in a tube and between parallel plates in which a profile for the RBC concentration field was imposed and the resulting platelet concentration field predicted. Compared to prevailing enhanced-diffusion models that dispersed the platelet concentration field, the ECD model was able to simulate a near-wall platelet excess, as observed experimentally. The extension of the ECD model depends only on the ability to prescribe the hematocrit distribution, and therefore may be applied to a wide variety of geometries to investigate platelet-mediated vascular disease and device-related thrombosis.

  8. An extended convection diffusion model for red blood cell-enhanced transport of thrombocytes and leukocytes

    International Nuclear Information System (INIS)

    Hund, S J; Antaki, J F

    2009-01-01

    Transport phenomena of platelets and white blood cells (WBCs) are fundamental to the processes of vascular disease and thrombosis. Unfortunately, the dilute volume occupied by these cells is not amenable to fluid-continuum modeling, and yet the cell count is large enough that modeling each individual cell is impractical for most applications. The most feasible option is to treat them as dilute species governed by convection and diffusion; however, this is further complicated by the role of the red blood cell (RBC) phase on the transport of these cells. We therefore propose an extended convection-diffusion (ECD) model based on the diffusive balance of a fictitious field potential, Ψ, that accounts for the gradients of both the dilute phase and the local hematocrit. The ECD model was applied to the flow of blood in a tube and between parallel plates in which a profile for the RBC concentration field was imposed and the resulting platelet concentration field predicted. Compared to prevailing enhanced-diffusion models that dispersed the platelet concentration field, the ECD model was able to simulate a near-wall platelet excess, as observed experimentally. The extension of the ECD model depends only on the ability to prescribe the hematocrit distribution, and therefore may be applied to a wide variety of geometries to investigate platelet-mediated vascular disease and device-related thrombosis.

  9. Evolutionary states of red-giant stars from grid-based modelling

    Science.gov (United States)

    Hekker, Saskia; Elsworth, Yvonne; Basu, Sarbani; Bellinger, Earl

    2017-10-01

    From its surface properties it can be difficult to determine whether a red-giant star is in its heliumcore-burning phase or only burning hydrogen in a shell around an inert helium core. Stars in either of these stages can have similar effective temperatures, radii and hence luminosities, i.e. they can be located at the same position in the Hertzsprung-Russell diagram. Asteroseismology - the study of the internal structure of stars through their global oscillations - can provide the necessary additional constraints to determine the evolutionary states of red-giant stars. Here, we present a method that uses grid-based modelling based on global asteroseismic properties (vmax, frequency of maximum oscillation power; and Δv, frequency spacing between modes of the same degree and consecutive radial orders) as well as effective temperature and metallicity to determine the evolutionary phases. This method is applicable even to timeseries data of limited length, although with a small fraction of miss-classifications.

  10. The Kings Cross fire: psychological reactions.

    Science.gov (United States)

    Turner, S W; Thompson, J; Rosser, R M

    1995-07-01

    The psychological reactions of 50 survivors of the King's Cross fire, which hit London's underground railway system on the 18th day of November 1987, are described. Results are presented for the Impact of Event scale, the General Health Questionnaire (28-item version), the Eysenck Personality Questionnaire and a King's Cross Event Schedule. These are investigated in relation to (a) validity measures, (b) relationships between exposure and personality, and (c) spontaneous de-briefing. Two thirds of the sample had significant levels of psychological distress (meeting the "caseness" criterion on the GHQ). Both personality (neuroticism and L-scale) and degree of trauma exposure were related to subsequent reaction. Spontaneous debriefing was associated with subjective benefit. Transportation disasters present particular problems in relation to research and service delivery.

  11. Feeding performance of king Mackerel, Scomberomorus cavalla.

    Science.gov (United States)

    Ferguson, Amber R; Huber, Daniel R; Lajeunesse, Marc J; Motta, Philip J

    2015-08-01

    Feeding performance is an organism's ability to capture and handle prey. Although bite force is a commonly used metric of feeding performance, other factors such as bite pressure and strike speed are also likely to affect prey capture. Therefore, this study investigated static bite force, dynamic speeds, and predator and prey forces resulting from ram strikes, as well as bite pressure of the king mackerel, Scomberomorus cavalla, in order to examine their relative contributions to overall feeding performance. Theoretical posterior bite force ranged from 14.0-318.7 N. Ram speed, recorded with a rod and reel incorporated with a line counter and video camera, ranged from 3.3-15.8B L/s. Impact forces on the prey ranged from 0.1-1.9 N. Bite pressure, estimated using theoretical bite forces at three gape angles and tooth cross-sectional areas, ranged from 1.7-56.9 MPa. Mass-specific bite force for king mackerel is relatively low in comparison with other bony fishes and sharks, with relatively little impact force applied to the prey during the strike. This suggests that king mackerel rely on high velocity chases and high bite pressure generated via sharp, laterally compressed teeth to maximize feeding performance. © 2015 Wiley Periodicals, Inc.

  12. Stick balancing, falls and Dragon-Kings

    Science.gov (United States)

    Cabrera, J. L.; Milton, J. G.

    2012-05-01

    The extent to which the occurrence of falls, the dominant feature of human attempts to balance a stick at their fingertip, can be predicted is examined in the context of the "Dragon-King" hypothesis. For skilled stick balancers, fluctuations in the controlled variable, namely the vertical displacement angle θ, exhibit power law behaviors. When stick balancing is made less stable by either decreasing the length of the stick or by requiring the subject to balance the stick on the surface of a table tennis racket, systematic departures from the power law behaviors are observed in the range of large θ. This observation raises the possibility that the presence of departures from the power law in the large length scale region, possibly Dragon-Kings, may identify situations in which the occurrence of a fall is more imminent. However, whether or not Dragon-Kings are observed, there is a Weibull-type survival function for stick falling. The possibility that increased risk of falling can, at least to some extent, be predicted from fluctuations in the controlled variable before the event occurs has important implications for the development of preventative strategies for the management of phenomena ranging from earthquakes to epileptic seizures to falls in the elderly.

  13. Investigation of membrane mechanics using spring networks: application to red-blood-cell modelling.

    Science.gov (United States)

    Chen, Mingzhu; Boyle, Fergal J

    2014-10-01

    In recent years a number of red-blood-cell (RBC) models have been proposed using spring networks to represent the RBC membrane. Some results predicted by these models agree well with experimental measurements. However, the suitability of these membrane models has been questioned. The RBC membrane, like a continuum membrane, is mechanically isotropic throughout its surface, but the mechanical properties of a spring network vary on the network surface and change with deformation. In this work spring-network mechanics are investigated in large deformation for the first time via an assessment of the effect of network parameters, i.e. network mesh, spring type and surface constraint. It is found that a spring network is conditionally equivalent to a continuum membrane. In addition, spring networks are employed for RBC modelling to replicate the optical tweezers test. It is found that a spring network is sufficient for modelling the RBC membrane but strain-hardening springs are required. Moreover, the deformation profile of a spring network is presented for the first time via the degree of shear. It is found that spring-network deformation approaches continuous as the mesh density increases. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. Bioavailability of ginsenosides from white and red ginsengs in the simulated digestion model.

    Science.gov (United States)

    Kim, Eun Ok; Cha, Kwang Hyun; Lee, Eun Ha; Kim, Sang Min; Choi, Sang Won; Pan, Cheol-Ho; Um, Byung-Hun

    2014-10-15

    This study aims to investigate the bioavailability of ginsenosides during simulated digestion of white (WG) and red (RG) ginseng powders. Stability, bioaccessibility, and permeability of ginsenosides present in WG and RG were studied in a Caco-2 cell culture model coupled with oral, gastric, and small intestinal simulated digestion. Most ginsenosides in WG and RG were stable (>90%) during the simulated digestion. Bioaccessibilities of total ginsenosides during in vitro digestion of WG and RG were similar at approximately 85%. However, the bioaccessibility of protopanaxatriol type ginsenosides in the early food phase was greater than that of the protopanaxadiol type. The less polar RG ginsenosides were released later following the jejunum phase. Ginsenosides had low permeability (digestion and that ginsenosides are poorly absorbed in humans.

  15. Modeling of daily body weights and body weight changes of Nordic Red cows.

    Science.gov (United States)

    Mäntysaari, P; Mäntysaari, E A

    2015-10-01

    Increased availability of automated weighing systems have made it possible to record massive amounts of body weight (BW) data in a short time. If the BW measurement is unbiased, the changes in BW reflect the energy status of the cow and can be used for management or breeding purposes. The usefulness of the BW data depends on the reliability of the measures. The noise in BW measurements can be smoothed by fitting a parametric or time series model into the BW measurements. This study examined the accuracy of different models to predict BW of the cows based on daily BW measurements and investigated the usefulness of modeling in increasing the value of BW measurements as management and breeding tools. Data included daily BW measurements, production, and intake from 230 Nordic Red dairy cows. The BW of the cows was recorded twice a day on their return from milking. In total, the data included 50,594 daily observations with 98,418 BW measurements. A clear diurnal change was present in the BW of the cows even if they had feed available 24 h. The daily average BW were used in the modeling. Five different models were tested: (1) a cow-wise fixed second-order polynomial regression model (FiX) including the exponential Wilmink term, (2) a random regression model with fixed and random animal lactation stage functions (MiX), (3) MiX with 13 periods of weighing added (PER), (4) natural cubic smoothing splines with 8 equally spaced knots (SPk8), and (5) spline model with no restriction on knots but a smoothing parameter corresponding to a fit of 5 degrees of freedom (SPdf5). In the original measured BW data, the within-animal variation was 6.4% of the total variance. Modeling decreased the within animal variation to levels of 2.9 to 5.1%. The smallest day-to-day variation and thereafter highest day-to-day repeatabilities were with PER and MiX models. The usability of modeled BW as energy balance (EB) indicator were evaluated by estimating relationships between EB, or EB

  16. Characterization of the complete mitochondrial genome of the king pigeon (Columba livia breed king).

    Science.gov (United States)

    Zhang, Rui-Hua; He, Wen-Xiao; Xu, Tong

    2015-06-01

    The king pigeon is a breed of pigeon developed over many years of selective breeding primarily as a utility breed. In the present work, we report the complete mitochondrial genome sequence of king pigeon for the first time. The total length of the mitogenome was 17,221 bp with the base composition of 30.14% for A, 24.05% for T, 31.82% for C, and 13.99% for G and an A-T (54.22 %)-rich feature was detected. It harbored 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes, and one non-coding control region (D-loop region). The arrangement of all genes was identical to the typical mitochondrial genomes of pigeon. The complete mitochondrial genome sequence of king pigeon would serve as an important data set of the germplasm resources for further study.

  17. A Multiscale Red Blood Cell Model with Accurate Mechanics, Rheology, and Dynamics

    Science.gov (United States)

    Fedosov, Dmitry A.; Caswell, Bruce; Karniadakis, George Em

    2010-01-01

    Abstract Red blood cells (RBCs) have highly deformable viscoelastic membranes exhibiting complex rheological response and rich hydrodynamic behavior governed by special elastic and bending properties and by the external/internal fluid and membrane viscosities. We present a multiscale RBC model that is able to predict RBC mechanics, rheology, and dynamics in agreement with experiments. Based on an analytic theory, the modeled membrane properties can be uniquely related to the experimentally established RBC macroscopic properties without any adjustment of parameters. The RBC linear and nonlinear elastic deformations match those obtained in optical-tweezers experiments. The rheological properties of the membrane are compared with those obtained in optical magnetic twisting cytometry, membrane thermal fluctuations, and creep followed by cell recovery. The dynamics of RBCs in shear and Poiseuille flows is tested against experiments and theoretical predictions, and the applicability of the latter is discussed. Our findings clearly indicate that a purely elastic model for the membrane cannot accurately represent the RBC's rheological properties and its dynamics, and therefore accurate modeling of a viscoelastic membrane is necessary. PMID:20483330

  18. Theoretical characterization of a model of aragonite crystal orientation in red abalone nacre

    International Nuclear Information System (INIS)

    Coppersmith, S N; Gilbert, P U P A; Metzler, R A

    2009-01-01

    Nacre, commonly known as mother-of-pearl, is a remarkable biomineral that in red abalone consists of layers of 400 nm thick aragonite crystalline tablets confined by organic matrix sheets, with the [0 0 1] crystal axes of the aragonite tablets oriented to within ±12 deg. from the normal to the layer planes. Recent experiments demonstrate that greater orientational order develops over a distance of tens of layers from the prismatic boundary at which nacre formation begins. Our previous simulations of a model in which the order develops because of differential tablet growth rates (oriented tablets growing faster than misoriented ones) yield patterns of tablets that agree qualitatively and quantitatively with the experimental measurements. This paper presents an analytical treatment of this model, focusing on how the dynamical development and eventual degree of order depend on model parameters. Dynamical equations for the probability distributions governing tablet orientations are introduced whose form can be determined from symmetry considerations and for which substantial analytic progress can be made. Numerical simulations are performed to relate the parameters used in the analytic theory to those in the microscopic growth model. The analytic theory demonstrates that the dynamical mechanism is able to achieve a much higher degree of order than naive estimates would indicate

  19. Analogue modelling of microcontinent formation: a case study from the Danakil Block, southern Red Sea

    Science.gov (United States)

    Molnar, Nicolas; Cruden, Alexander; Betts, Peter

    2017-04-01

    The kinematic evolution of the Danakil Block is well constrained but the processes responsible for the formation of an isolated continental segment around 13 Ma ago with an independent pole of rotation are still matter of debate. We performed three-dimensional analogue experiments of rotational continental extension containing a pre-existing linear weakness zones in the lithospheric mantle to investigate the formation of the Red Sea, including the Danakil Block. We imposed a rotational extensional boundary condition that simulates the progressive anticlockwise rotation of the Arabian Plate with respect to the Nubia Plate over the last 13-15 Ma and we simulated the presence of a narrow thermal anomaly related to the northward channelling of Afar plume by varying the viscosity of the model lithospheric mantle. The results from experiments containing a linear zone of weakness oriented at low angles with respect to the rift axis show that early stages of deformation are characterised by the development of two rift sub-parallel compartments that delimit an intra-rift block in the vicinity of the weak lithosphere boundary zone, which are analogous to the two rift branches that confine the Danakil Block in the southern Red Sea. The imposed rotational boundary condition creates a displacement gradient along the intra-rift block and prevents the nucleation of the early rift compartments to the north of the block, enhancing the formation of an independently rotating intra-rift segment. Comparison with geodetic data supports our modelling results, which are also in agreement with the "crank-arm" model of Sichler (1980. La biellette Danakile: un modèle pour l'évolution géodynamique de l'Afar. Bull. la Société Géologique Fr. 22, 925-933). Additional analogue models of i) orthogonal extension with an identical lithospheric mantle weakness and, ii) rotational extension with a homogeneous lithosphere (i.e., no lithospheric mantle weakness) show no evidence of developing

  20. Brazilian red propolis attenuates hypertension and renal damage in 5/6 renal ablation model.

    Directory of Open Access Journals (Sweden)

    Flávio Teles

    Full Text Available The pathogenic role of inflammation and oxidative stress in chronic kidney disease (CKD is well known. Anti-inflammatories and antioxidant drugs has demonstrated significant renoprotection in experimental nephropathies. Moreover, the inclusion of natural antioxidants derived from food and herbal extracts (such as polyphenols, curcumin and lycopene as an adjuvant therapy for slowing CKD progression has been largely tested. Brazilian propolis is a honeybee product, whose anti-inflammatory, antimicrobial and antioxidant effects have been widely shown in models of sepsis, cancer, skin irritation and liver fibrosis. Furthermore, previous studies demonstrated that this compound promotes vasodilation and reduces hypertension. However, potential renoprotective effects of propolis in CKD have never been investigated. The aim of this study was to evaluate the effects of a subtype of Brazilian propolis, the Red Propolis (RP, in the 5/6 renal ablation model (Nx. Adult male Wistar rats underwent Nx and were divided into untreated (Nx and RP-treated (Nx+RP groups, after 30 days of surgery; when rats already exhibited marked hypertension and proteinuria. Animals were observed for 90 days from the surgery day, when Nx+RP group showed significant reduction of hypertension, proteinuria, serum creatinine retention, glomerulosclerosis, renal macrophage infiltration and oxidative stress, compared to age-matched untreated Nx rats, which worsened progressively over time. In conclusion, RP treatment attenuated hypertension and structural renal damage in Nx model. Reduction of renal inflammation and oxidative stress could be a plausible mechanism to explain this renoprotection.

  1. PermVeg: A model to design crop sequences for permanent vegetable production systems in the Red River Delta, Vietnam

    NARCIS (Netherlands)

    Pham Thi Thu Huong, Huong; Everaarts, A.P.; Berg, van den W.; Neeteson, J.J.; Struik, P.C.

    2014-01-01

    The constraints in current vegetable production systems in the Red River Delta, Vietnam, in which vegetables are rotated with flooded rice, called for the design of alternative systems of permanent vegetable production. The practical model, PermVeg, was developed to generate vegetable crop sequences

  2. Improved viscosity modeling in patients with type 2 diabetes mellitus by accounting for enhanced red blood cell aggregation tendency

    NARCIS (Netherlands)

    Mutsaerts, Henri J. M. M.; Out, Mattijs; Goedhart, Peter T.; Ince, Can; Hardeman, Max R.; Romijn, Johannes A.; Rabelink, Ton J.; Reiber, Johan H. C.; Box, Frieke M. A.

    2010-01-01

    Aims: Distorted wall shear stress (WSS) in patients with type 2 diabetes mellitus (T2DM) may be partly explained by an altered red blood cell aggregation tendency (RAT) on viscosity at low shear rate (SR). The present study evaluates viscosity modeling by implementation of hematocrit and RAT in

  3. Color Gradient in the King Type Globular Cluster NGC 7089

    Directory of Open Access Journals (Sweden)

    Young-Jong Sohn

    1999-12-01

    Full Text Available We use BV CCD images to investigate the reality of the color gradient within a King type globular cluster NGC 7089. Surface photometry shows that there is a strong radial color gradient in the central region of the cluster in the sense of bluer center with the amplitude of -0.39 +/- 0.07 mag/arcsec2 in (B - V. In the outer region of the cluster, however, the radial color gradient shows a reverse case, i.e., redder toward the center. (B - V color profile which was derived from resolved stars in VGC 7089 field also shows a significant color gradient in the central region of the clusters, indicating that lights from the combination of red giant stars and blue horizontal branch stars cause the radial color gradient. Color gradient of the outer region of NGC 7089 may be due to the unresolved background of the cluster. Similar color gradients in the central area of clusters have been previously observed exserved exclusively in highly concentrated systems classified as post core collapse clusters. We caution, however, to confirm the reality of the color gradient from resolved stars, we need more accurate imaging data of the cluster with exceptional seeing condition because the effect of completeness correlates with local density of stars.

  4. King customer forever: Customer satisfaction and beyond

    Directory of Open Access Journals (Sweden)

    Myuers James

    2004-01-01

    Full Text Available "King Customer!" So proclaimed the front cover of Business Week in a 1989 issue. At about the same time, "Rediscovering the Customer" was the title of a series of company vignettes in Fortune magazine. And a Wall Street Journal article asked, "For Customers, More Than Lip Service?" Combined, these three prestigious business publications reflected a new era in business firms perceptions of their customers and the role they should play in the formulation of company strategies and priorities. Had the "Era of the Customer" finally arrived in American business? .

  5. The Red Flour Beetle as a Model for Bacterial Oral Infections

    Science.gov (United States)

    Milutinović, Barbara; Stolpe, Clemens; Peuβ, Robert; Armitage, Sophie A. O.; Kurtz, Joachim

    2013-01-01

    Experimental infection systems are important for studying antagonistic interactions and coevolution between hosts and their pathogens. The red flour beetle Tribolium castaneum and the spore-forming bacterial insect pathogen Bacillus thuringiensis (Bt) are widely used and tractable model organisms. However, they have not been employed yet as an efficient experimental system to study host-pathogen interactions. We used a high throughput oral infection protocol to infect T. castaneum insects with coleopteran specific B. thuringiensis bv. tenebrionis (Btt) bacteria. We found that larval mortality depends on the dietary spore concentration and on the duration of exposure to the spores. Furthermore, differential susceptibility of larvae from different T. castaneum populations indicates that the host genetic background influences infection success. The recovery of high numbers of infectious spores from the cadavers indicates successful replication of bacteria in the host and suggests that Btt could establish infectious cycles in T. castaneum in nature. We were able to transfer plasmids from Btt to a non-pathogenic but genetically well-characterised Bt strain, which was thereafter able to successfully infect T. castaneum, suggesting that factors residing on the plasmids are important for the virulence of Btt. The availability of a genetically accessible strain will provide an ideal model for more in-depth analyses of pathogenicity factors during oral infections. Combined with the availability of the full genome sequence of T. castaneum, this system will enable analyses of host responses during infection, as well as addressing basic questions concerning host-parasite coevolution. PMID:23737991

  6. The red flour beetle as a model for bacterial oral infections.

    Directory of Open Access Journals (Sweden)

    Barbara Milutinović

    Full Text Available Experimental infection systems are important for studying antagonistic interactions and coevolution between hosts and their pathogens. The red flour beetle Tribolium castaneum and the spore-forming bacterial insect pathogen Bacillus thuringiensis (Bt are widely used and tractable model organisms. However, they have not been employed yet as an efficient experimental system to study host-pathogen interactions. We used a high throughput oral infection protocol to infect T. castaneum insects with coleopteran specific B. thuringiensis bv. tenebrionis (Btt bacteria. We found that larval mortality depends on the dietary spore concentration and on the duration of exposure to the spores. Furthermore, differential susceptibility of larvae from different T. castaneum populations indicates that the host genetic background influences infection success. The recovery of high numbers of infectious spores from the cadavers indicates successful replication of bacteria in the host and suggests that Btt could establish infectious cycles in T. castaneum in nature. We were able to transfer plasmids from Btt to a non-pathogenic but genetically well-characterised Bt strain, which was thereafter able to successfully infect T. castaneum, suggesting that factors residing on the plasmids are important for the virulence of Btt. The availability of a genetically accessible strain will provide an ideal model for more in-depth analyses of pathogenicity factors during oral infections. Combined with the availability of the full genome sequence of T. castaneum, this system will enable analyses of host responses during infection, as well as addressing basic questions concerning host-parasite coevolution.

  7. Korean red ginseng extract ameliorates skin lesions in NC/Nga mice: an atopic dermatitis model.

    Science.gov (United States)

    Lee, Ji Hyun; Cho, Sang Hyun

    2011-01-27

    Korean red ginseng (KRG, Panax ginseng C.A. Meyer) has traditionally been considered to harbor anti-allergic effects, however its action on atopic dermatitis (AD) is unclear. Therefore, we investigated the effect of KRG on AD using NC/Nga mice as an AD model. In addition, we examined the effect of aprepitant (substance P specific neurokinin receptor antagonist) on AD. The KRG extract and aprepitant were administered orally to NC/Nga mice. The efficacy of KRG and aprepitant was evaluated by assessing total clinical severity score, ear thickness, serum IgE level and histology. In addition, mRNA and protein expression were measured by real-time RT-PCR and immunohistochemistry, respectively. The KRG extract significantly reduced the total clinical severity score, ear thickness and the level of serum IgE in AD mouse model, whereas aprepitant reduced only the serum IgE level. KRG not only decreased TNF-α, IFN-γ and substance P but also reduced the infiltration of FOXP3+ regulatory T (Treg) cells and CD1a+ Langerhans cells in the lesions, whereas aprepitant decreased only substance P and the infiltration of Treg cells. These results suggest that KRG extract may be a potential therapeutic modality for AD and aprepitant could be used as adjunctive agent to control pruritus in AD. Crown Copyright © 2010. Published by Elsevier Ireland Ltd. All rights reserved.

  8. Modelling Perception of Structure and Affect in Music: Spectral Centroid and Wishart's Red Bird

    Directory of Open Access Journals (Sweden)

    Roger T. Dean

    2011-12-01

    Full Text Available Pearce (2011 provides a positive and interesting response to our article on time series analysis of the influences of acoustic properties on real-time perception of structure and affect in a section of Trevor Wishart’s Red Bird (Dean & Bailes, 2010. We address the following topics raised in the response and our paper. First, we analyse in depth the possible influence of spectral centroid, a timbral feature of the acoustic stream distinct from the high level general parameter we used initially, spectral flatness. We find that spectral centroid, like spectral flatness, is not a powerful predictor of real-time responses, though it does show some features that encourage its continued consideration. Second, we discuss further the issue of studying both individual responses, and as in our paper, group averaged responses. We show that a multivariate Vector Autoregression model handles the grand average series quite similarly to those of individual members of our participant groups, and we analyse this in greater detail with a wide range of approaches in work which is in press and continuing. Lastly, we discuss the nature and intent of computational modelling of cognition using acoustic and music- or information theoretic data streams as predictors, and how the music- or information theoretic approaches may be applied to electroacoustic music, which is ‘sound-based’ rather than note-centred like Western classical music.

  9. Red wine and green tea reduce H pylori- or VacA-induced gastritis in a mouse model

    Science.gov (United States)

    Ruggiero, Paolo; Rossi, Giacomo; Tombola, Francesco; Pancotto, Laura; Lauretti, Laura; Del Giudice, Giuseppe; Zoratti, Mario

    2007-01-01

    AIM: To investigate whether red wine and green tea could exert anti-H pylori or anti-VacA activity in vivo in a mouse model of experimental infection. METHODS: Ethanol-free red wine and green tea concentrates were administered orally as a mixture of the two beverages to H pylori infected mice, or separately to VacA-treated mice. Gastric colonization and gastric inflammation were quantified by microbiological, histopathological, and immunohistochemical analyses. RESULTS: In H pylori-infected mice, the red wine and green tea mixture significantly prevented gastritis and limited the localization of bacteria and VacA to the surface of the gastric epithelium. Similarly, both beverages significantly prevented gastric epithelium damage in VacA-treated mice; green tea, but not red wine, also altered the VacA localization in the gastric epithelium. CONCLUSION: Red wine and green tea are able to prevent H pylori-induced gastric epithelium damage, possibly involving VacA inhibition. This observation supports the possible relevance of diet on the pathological outcome of H pylori infection. PMID:17230601

  10. The Red MSX Source survey: critical tests of accretion models for the formation of massive stars

    Science.gov (United States)

    Davies, Ben; Hoare, Melvin G.; Lumsden, Stuart L.; Hosokawa, Takashi; Oudmaijer, René D.; Urquhart, James S.; Mottram, Joseph C.; Stead, Joseph

    2011-09-01

    There is currently no accepted theoretical framework for the formation of the most massive stars, and the manner in which protostars continue to accrete and grow in mass beyond ˜10 M⊙ is still a controversial topic. In this study we use several prescriptions of stellar accretion and a description of the Galactic gas distribution to simulate the luminosities and spatial distribution of massive protostellar population of the Galaxy. We then compare the observables of each simulation to the results of the Red MSX Source (RMS) survey, a recently compiled data base of massive young stellar objects (YSO). We find that the observations are best matched by accretion rates which increase as the protostar grows in mass, such as those predicted by the turbulent core and competitive accretion (i.e. Bondi-Hoyle) models. These 'accelerating accretion' models provide very good qualitative and quantitative fits to the data, though we are unable to distinguish between these two models on our simulations alone. We rule out models with accretion rates which are constant with time, and those which are initially very high and which fall away with time, as these produce results which are quantitatively and/or qualitatively incompatible with the observations. To simultaneously match the low- and high-luminosity YSO distribution we require the inclusion of a 'swollen-star' pre-main-sequence phase, the length of which is well-described by the Kelvin-Helmholz time-scale. Our results suggest that the lifetime of the YSO phase is ˜105 yr, whereas the compact H II region phase lasts between ˜2 and 4 × 105 yr depending on the final mass of the star. Finally, the absolute numbers of YSOs are best matched by a globally averaged star formation rate for the Galaxy of 1.5-2 M⊙.

  11. Modeling the impacts of hunting on the population dynamics of red howler monkeys (Alouatta seniculus)

    Science.gov (United States)

    Wiederholt, Ruscena; Fernandez-Duque, Eduardo; Diefenbach, Duane R.; Rudran, Rasanayagam

    2010-01-01

    Overexploitation of wildlife populations occurs across the humid tropics and is a significant threat to the long-term survival of large-bodied primates. To investigate the impacts of hunting on primates and ways to mitigate them, we developed a spatially explicit, individual-based model for a landscape that included hunted and un-hunted areas. We used the large-bodied neotropical red howler monkey (Alouatta seniculus) as our case study species because its life history characteristics make it vulnerable to hunting. We modeled the influence of different rates of harvest and proportions of landscape dedicated to un-hunted reserves on population persistence, population size, social dynamics, and hunting yields of red howler monkeys. In most scenarios, the un-hunted populations maintained a constant density regardless of hunting pressure elsewhere, and allowed the overall population to persist. Therefore, the overall population was quite resilient to extinction; only in scenarios without any un-hunted areas did the population go extinct. However, the total and hunted populations did experience large declines over 100 years under moderate and high hunting pressure. In addition, when reserve area decreased, population losses and losses per unit area increased disproportionately. Furthermore, hunting disrupted the social structure of troops. The number of male turnovers and infanticides increased in hunted populations, while birth rates decreased and exacerbated population losses due to hunting. Finally, our results indicated that when more than 55% of the landscape was harvested at high (30%) rates, hunting yields, as measured by kilograms of biomass, were less than those obtained from moderate harvest rates. Additionally, hunting yields, expressed as the number of individuals hunted/year/km2, increased in proximity to un-hunted areas, and suggested that dispersal from un-hunted areas may have contributed to hunting sustainability. These results indicate that un

  12. Extreme Precipitation, Stormwater, and Flooding in King County: Co-producing Research to Support Adaptation

    Science.gov (United States)

    Mauger, G. S.; Lorente-Plazas, R.; Salathe, E. P., Jr.; Mitchell, T. P.; Simmonds, J.; Lee, S. Y.; Hegewisch, K.; Warner, M.; Won, J.

    2017-12-01

    King County has experienced 12 federally declared flood disasters since 1990, and tens of thousands of county residents commute through, live, and work in floodplains. In addition to flooding, stormwater is a critical management challenge, exacerbated by aging infrastructure, combined sewer and drainage systems, and continued development. Even absent the effects of climate change these are challenging management issues. Recent studies clearly point to an increase in precipitation extremes for the Pacific Northwest (e.g., Warner et al. 2015). Yet very little information is available on the magnitude and spatial distribution of this change. Others clearly show that local-scale changes in extreme precipitation can only be accurately quantified with dynamical downscaling, i.e.: using a regional climate model. This talk will describe a suite of research and adaptation efforts developed in a close collaboration between King County and the UW Climate Impacts Group. Building on past collaborations, research efforts were defined in collaboration with King County managers, addressing three key science questions: (1) How are the mesoscale variations in extreme precipitation modulated by changes in large-scale weather conditions? (2) How will precipitation extremes change? This was assessed via two new high-resolution regional model projections using the Weather Research and Forecasting (WRF) mesoscale model (Skamarock et al. 2005). (3) What are the implications for stormwater and flooding in King County? This was assessed by both exploring the statistics of hourly precipitation extremes in the new projections, as well as new hydrologic modeling to assess the implications for river flooding. The talk will present results from these efforts, review the implications for King County planning and infrastructure, and synthesize lessons learned and opportunities for additional work.

  13. Geodynamic modelling of the rift-drift transition: Application to the Red Sea

    Science.gov (United States)

    Fierro, E.; Schettino, A.; Capitanio, F. A.; Ranalli, G.

    2017-12-01

    The onset of oceanic accretion after a rifting phase is generally accompanied by an initial fast pulse of spreading in the case of volcanic margins, such that the effective spreading rate exceeds the relative far-field velocity between the two plates for a short time interval. This pulse has been attributed to edge-driven convention (EDC), although our numerical modelling shows that the shear stress at the base of the lithosphere cannot exceed 1 MPa. In general, we have developed a 2D numerical model of the mantle instabilities during the rifting phase, in order to determine the geodynamic conditions at the rift-drift transition. The model was tested using Underworld II software, variable rheological parameters, and temperature and stress-dependent viscosity. Our results show an increase of strain rates at the top of the lithosphere with the lithosphere thickness as well as with the initial width of the margin up to 300 km. Beyond this value, the influence of the initial rift width can be neglected. An interesting outcome of the numerical model is the existence of an axial zone characterized by higher strain rates, which is flanked by two low-strain stripes. As a consequence, the model suggests the existence of an area of syn-rift compression within the rift valley. Regarding the post-rift phase, we propose that at the onset of a seafloor spreading, a phase of transient creep allows the release of the strain energy accumulated in the mantle lithosphere during the rifting phase, through anelastic relaxation. Then, the conjugated margins would be subject to post-rift contraction and eventually to tectonic inversion of the rift structures. To explore the tenability of this model, we introduce an anelastic component in the lithosphere rheology, assuming both the classical linear Kelvin-Voigt rheology and a non-linear Kelvin model. The non-linear model predicts viable relaxation times ( 1-2Myrs) to explain the post-rift tectonic inversion observed along the Arabian

  14. Curse and consequence: King Lear's destructive narcissism.

    Science.gov (United States)

    Schafer, Roy

    2010-12-01

    Shock, pain and antipathy are common audience responses to King Lear's violent abuse of Cordelia in Scene 1 of King Lear; however, the play then shifts so rapidly to other dramatic relationships and events that it tends to push these feelings out of mind. This shift is here regarded as a seduction to repress the fear and antipathy aroused by Lear. This effect opens the way to sympathetic identification with him in his subsequent humiliation, suffering and madness. These contrasting responses help build a tragic structure in which a more complex Lear becomes the victim of his curse on Cordelia. The seductive design resembles efforts by analytic patients to induce the analyst into repressively neglecting significant aspects of transference that require analytic attention. And Lear's bearing the consequences of his curse is likened to aspects of the decompensations of severely narcissistic patients. Additionally, to the extent that the audience has unconsciously identified with Lear's violence and participated emotionally in other painful scenes, as is likely to be the case, it has been unconsciously reacting as well with guilt and depressive anxiety. These reactions increase readiness to be diverted from destructive narcissism and responses to it. Copyright © 2010 Institute of Psychoanalysis.

  15. Model of acceptance of a new type of beverage: application to natural sparkling red wine

    Energy Technology Data Exchange (ETDEWEB)

    Olarte, C.; Pelegrín, J.; Reinares, E.

    2017-09-01

    Wine is a traditional beverage with a saturated market, in which consumers are open to innovation. In this context, an innovative experience was launched to create a new natural sparkling red wine with a view to diversifying production and studying its acceptance. This paper uses an original acceptance model for new foods called the Cognitive-Affective-Normative (CAN) model. The model was tested on a sample of 500 Spanish consumers in a real-world test context and explains 64.1% of the intention to consume the new wine. The results showed the importance of the cognitive factor in consumer intention. In particular, sensory and price benefits were found to be the key criteria explaining the intention to consume (41.34%). The results also confirmed the usefulness of expanding the factors that determine new food acceptance to include the emotional and normative dimensions of consumer behaviour. The social norm (18.54%) and affective factors (4.2%) contributed to the explanation of the underlying reasons influencing consumers’ assessments of the product. It is proposed that efforts focus on new visual, olfactory and taste-related sensations with a view to producing an appetising product that offers good value for money. Research and development institutes should innovate towards products that highlight these sensations. Therefore, attention should be drawn to the importance of acting on potential consumers’ reference groups and membership groups, with a view to involving them in recommending the product. Managers should focus on measuring and influencing social opinion, working on marketing communication to achieve acceptance.

  16. Model of acceptance of a new type of beverage: application to natural sparkling red wine

    International Nuclear Information System (INIS)

    Olarte, C.; Pelegrín, J.; Reinares, E.

    2017-01-01

    Wine is a traditional beverage with a saturated market, in which consumers are open to innovation. In this context, an innovative experience was launched to create a new natural sparkling red wine with a view to diversifying production and studying its acceptance. This paper uses an original acceptance model for new foods called the Cognitive-Affective-Normative (CAN) model. The model was tested on a sample of 500 Spanish consumers in a real-world test context and explains 64.1% of the intention to consume the new wine. The results showed the importance of the cognitive factor in consumer intention. In particular, sensory and price benefits were found to be the key criteria explaining the intention to consume (41.34%). The results also confirmed the usefulness of expanding the factors that determine new food acceptance to include the emotional and normative dimensions of consumer behaviour. The social norm (18.54%) and affective factors (4.2%) contributed to the explanation of the underlying reasons influencing consumers’ assessments of the product. It is proposed that efforts focus on new visual, olfactory and taste-related sensations with a view to producing an appetising product that offers good value for money. Research and development institutes should innovate towards products that highlight these sensations. Therefore, attention should be drawn to the importance of acting on potential consumers’ reference groups and membership groups, with a view to involving them in recommending the product. Managers should focus on measuring and influencing social opinion, working on marketing communication to achieve acceptance.

  17. Modeling of Biomechanics and Biorheology of Red Blood Cells in Type 2 Diabetes Mellitus.

    Science.gov (United States)

    Chang, Hung-Yu; Li, Xuejin; Karniadakis, George Em

    2017-07-25

    Erythrocytes in patients with type-2 diabetes mellitus (T2DM) are associated with reduced cell deformability and elevated blood viscosity, which contribute to impaired blood flow and other pathophysiological aspects of diabetes-related vascular complications. In this study, by using a two-component red blood cell (RBC) model and systematic parameter variation, we perform detailed computational simulations to probe the alteration of the biomechanical, rheological, and dynamic behavior of T2DM RBCs in response to morphological change and membrane stiffening. First, we examine the elastic response of T2DM RBCs subject to static tensile forcing and their viscoelastic relaxation response upon release of the stretching force. Second, we investigate the membrane fluctuations of T2DM RBCs and explore the effect of cell shape on the fluctuation amplitudes. Third, we subject the T2DM RBCs to shear flow and probe the effects of cell shape and effective membrane viscosity on their tank-treading movement. In addition, we model the cell dynamic behavior in a microfluidic channel with constriction and quantify the biorheological properties of individual T2DM RBCs. Finally, we simulate T2DM RBC suspensions under shear and compare the predicted viscosity with experimental measurements. Taken together, these simulation results and their comparison with currently available experimental data are helpful in identifying a specific parametric model-the first of its kind, to our knowledge-that best describes the main hallmarks of T2DM RBCs, which can be used in future simulation studies of hematologic complications of T2DM patients. Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  18. Model of acceptance of a new type of beverage: application to natural sparkling red wine

    Directory of Open Access Journals (Sweden)

    Cristina Olarte

    2017-04-01

    Full Text Available Wine is a traditional beverage with a saturated market, in which consumers are open to innovation. In this context, an innovative experience was launched to create a new natural sparkling red wine with a view to diversifying production and studying its acceptance. This paper uses an original acceptance model for new foods called the Cognitive-Affective-Normative (CAN model. The model was tested on a sample of 500 Spanish consumers in a real-world test context and explains 64.1% of the intention to consume the new wine.  The results showed the importance of the cognitive factor in consumer intention. In particular, sensory and price benefits were found to be the key criteria explaining the intention to consume (41.34%. The results also confirmed the usefulness of expanding the factors that determine new food acceptance to include the emotional and normative dimensions of consumer behaviour. The social norm (18.54% and affective factors (4.2% contributed to the explanation of the underlying reasons influencing consumers’ assessments of the product. It is proposed that efforts focus on new visual, olfactory and taste-related sensations with a view to producing an appetising product that offers good value for money. Research and development institutes should innovate towards products that highlight these sensations. Therefore, attention should be drawn to the importance of acting on potential consumers’ reference groups and membership groups, with a view to involving them in recommending the product. Managers should focus on measuring and influencing social opinion, working on marketing communication to achieve acceptance.

  19. King Kong tuli unenäost / Alar Niineväli

    Index Scriptorium Estoniae

    Niineväli, Alar

    2005-01-01

    Hiigelgorilla King Kongi sünd kinolinal 1933.a. Merian C. Cooperi õudusfilmis "King Kong" ja koletise hilisemad tulemised, ka koos jaapanlaste Godzillaga (1962) ja Tarzaniga india filmis "Tarzan ja King Kong" (1965)

  20. Development of the Red Sea Biogeographic Information System

    KAUST Repository

    Machda, Fahmi

    2010-05-01

    Marine studies, surveys, and observational activities are continuously generating new and diverse data, which are hard to keep track of with tables and spreadsheets. Integrated data and information management systems that collect, analyze, and combine data are needed in order to provide a comprehensive picture of marine environments under study. For these reasons, we started to develop the Red Sea Biogeographic Information System (RBIS) at King Abdullah University of Science and Technology (KAUST) as a web application utilizing the most updated Web 2.0 technologies. RBIS is designed to have an easily accessible interface that is able to host and display research activities conducted in the Red Sea. Its data model is designed to deal with any kind of marine data. For its data structure, RBIS is organizing the data into three main categories: biological data, physicochemical data, and human activities. Spatial distribution of these data is visualized on a Google-Maps mashup. Dynamic charts are used to visualize the statistics of the data. With these functionalities, data model, and data structure, RBIS is able to organize, visualize, and do instantly combined analyses of research data from the Red Sea. The current version is accessible at http://www.kaust.edu.sa/rbis. © 2010 IEEE.

  1. 75 FR 11134 - North Pacific Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-03-10

    ... results and model sensitivity; review preliminary draft Crab Annual Catch Limits (ACLs)and rebuilding for Bristol Bay Red King Crab, snow crab, Tanner crab, Norton Sound Red King Crab, Pribilof Island Red King...

  2. Prebiotic evaluation of red seaweed (Kappaphycus alvarezii) using in vitro colon model.

    Science.gov (United States)

    Bajury, Dayang Marshitah; Rawi, Muhamad Hanif; Sazali, Iqbal Hakim; Abdullah, Aminah; Sarbini, Shahrul Razid

    2017-11-01

    Red seaweed (Kappaphycus alvarezii) cultivated from Sabah (RSS) and Langkawi (RSL) were digested using in vitro mouth, gastric and duodenal model. The digested seaweed then fermented in a pH-controlled batch culture system inoculated with human faeces to mimic the distal colon. Bacterial enumeration were monitored using fluorescent in situ hybridisation, and the fermentation end products, the short chain fatty acids (SCFA), were analysed using HPLC. Both RSS and RSL showed significant increase of Bifidobacterium sp.; from log 10 7.96 at 0 h to log 10 8.72 at 24 h, and from log 10 7.96 at 0 h to log 10 8.60 at 24 h, respectively, and shows no significant difference when compared to the Bifidobacterium sp. count at 24 h of inulin fermentation. Both seaweeds also showed significant increase in total SCFA production, particularly acetate and propionate. Overall, this data suggested that K. alvarezii might have the potential as a prebiotic ingredient.

  3. Reactive flow models of the Anarraaq Zn-Pb-Ag deposit, Red Dog district, Alaska

    Science.gov (United States)

    Schardt, Christian; Garven, Grant; Kelley, Karen D.; Leach, David L.

    2008-09-01

    The Red Dog ore deposit district in the Brooks Range of northern Alaska is host to several high-grade, shale-hosted Zn + Pb deposits. Due to the complex history and deformation of these ore deposits, the geological and hydrological conditions at the time of formation are poorly understood. Using geological observations and fluid inclusion data as constraints, numerical heat and fluid flow simulations of the Anarraaq ore deposit environment and coupled reactive flow simulations of a section of the ore body were conducted to gain more insight into the conditions of ore body formation. Results suggest that the ore body and associated base metal zonation may have formed by the mixing of oxidized, saline, metal-bearing hydrothermal fluids (<200°C) with reducing, HS-rich pore fluids within radiolarite-rich host rocks. Sphalerite and galena concentrations and base metal sulfide distribution are primarily controlled by the nature of the pore fluids, i.e., the extent and duration of the HS- source. Forward modeling results also predict the distribution of pyrite and quartz in agreement with field observations and indicate a reaction front moving from the initial mixing interface into the radiolarite rocks. Heuristic mass calculations suggest that ore grades and base metal accumulation comparable to those found in the field (18% Zn, 5% Pb) are predicted to be reached after about 0.3 My for initial conditions (30 ppm Zn, 3 ppm Pb; 20% deposition efficiency).

  4. On the stability and multi-stability of a TCP/RED congestion control model with state-dependent delay and discontinuous marking function

    Science.gov (United States)

    Zhang, Shu; Xu, Jian; Chung, Kwok-wai

    2015-05-01

    Random early detection (RED) is an effective algorithm to control the Internet congestion. However, researches on RED parameters are difficult since there are state-dependent delay and discontinuous terms on the right-hand side of the model. We smooth the model by hyperbolic tangent function and reformulate it by a switch function to keep state variables positive. Numerical simulations on the original system validates the reformulated model. The multi-stability phenomenon is observed and some suggestions on the selection of RED parameters are given to enhance the global stability of the model by numerical bifurcation continuation on the reformulated model.

  5. Green tea supplementation produces better neuroprotective effects than red and black tea in Alzheimer-like rat model.

    Science.gov (United States)

    Schimidt, Helen L; Garcia, Alexandre; Martins, Alexandre; Mello-Carpes, Pamela B; Carpes, Felipe P

    2017-10-01

    Green tea from Camellia sinensis plays a neuroprotective role in different neurodegenerative conditions, such as memory deficits in Alzheimer disease (AD). However, whether other teas from Camellia sinensis present similar neuroprotective effect still is not clear. Here we investigate effects of green, red and black tea supplementation on memory and hippocampus oxidative status in a rat model of Alzheimer-like disease (AD-like). Wistar male rats were supplemented with green, red or black tea during 8weeks before Aβ intra-hippocampal injection (2μL of Aβ-25-35, CA1 region). AD and sham rats were submitted to memory tests. After euthanasia, oxidative status in the bilateral hippocampus was quantified. Green and red teas avoid memory deficits in AD rats, but only green tea also avoids oxidative stress and damage in the hippocampus. Green tea was more effective for neuroprotection than red and black teas from the Camellia sinensis in the AD rat model. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. The Applicability of Governance at King Saud University in Riyadh

    Science.gov (United States)

    Kentab, Mohammad Y.

    2018-01-01

    The problem of the study revolves around the application of the requirements of governance at King Saud University. The study aims to identify the extent of governance requirements at King Saud University as seen by faculty members through transparency, accountability, organizational structure, laws, regulations, and justice. To achieve the…

  7. Validation of the King's Health Questionnairefor South Africa in ...

    African Journals Online (AJOL)

    To validate the King's Health Questionnaire for urinary incontinence in the local South African English, Afrikaans and. isiXhosa female ... This study provides a validated English, Afrikaans and isiXhosa language version of the King's Health Questionnaire for ... to social withdrawal, lowered self-esteem, marital problems and.

  8. 78 FR 5247 - Martin Luther King, Jr., Federal Holiday, 2013

    Science.gov (United States)

    2013-01-24

    ... Vol. 78 Thursday, No. 16 January 24, 2013 Part II The President Proclamation 8927--Martin Luther..., 2013 Martin Luther King, Jr., Federal Holiday, 2013 By the President of the United States of America A... thousands upon thousands rallying for jobs and freedom, the Reverend Dr. Martin Luther King, Jr., delivered...

  9. Growth, chemical components and ensiling characteristics of king ...

    African Journals Online (AJOL)

    In order to effectively use and ensile king grass (Pennisetum purpureum × Pennisetum americanum), the present research investigated growth rate, yield, chemical components and silage fermentation quality of different cuttings. King grass was harvested four times, and the 1st and 3rd cuttings were ensiled directly or after ...

  10. Mapping wilderness character in Sequoia and Kings Canyon National Parks

    Science.gov (United States)

    James Tricker; Peter Landres; Gregg Fauth; Paul Hardwick; Alex Eddy

    2014-01-01

    The Sequoia-Kings Canyon Wilderness was established in September of 1984 when President Ronald Reagan signed the California Wilderness Act (PL 98-425). In March 2009, President Barack Obama signed the Omnibus Public Land Management Act (PL 111-11) designating the John Krebs Wilderness and the Sequoia-Kings Canyon Wilderness Addition (all wholly contained within SEKI)....

  11. King IV is here: Corporate Governance in South Africa revisited ...

    African Journals Online (AJOL)

    Codes of Conduct for corporate governance have been evolving over the past few decades. The article assesses the progress in local corporate governance with the launch of the latest King IV code for South African corporations in 2016 and argues that unless there is transformation in these critical areas, King IV is not ...

  12. Modeling suitable habitat of invasive red lionfish Pterois volitans (Linnaeus, 1758) in North and South America’s coastal waters

    Science.gov (United States)

    Evangelista, Paul H.; Young, Nicholas E.; Schofield, Pamela J.; Jarnevich, Catherine S.

    2016-01-01

    We used two common correlative species-distribution models to predict suitable habitat of invasive red lionfish Pterois volitans (Linnaeus, 1758) in the western Atlantic and eastern Pacific Oceans. The Generalized Linear Model (GLM) and the Maximum Entropy (Maxent) model were applied using the Software for Assisted Habitat Modeling. We compared models developed using native occurrences, using non-native occurrences, and using both native and non-native occurrences. Models were trained using occurrence data collected before 2010 and evaluated with occurrence data collected from the invaded range during or after 2010. We considered a total of 22 marine environmental variables. Models built with non-native only or both native and non-native occurrence data outperformed those that used only native occurrences. Evaluation metrics based on the independent test data were highest for models that used both native and non-native occurrences. Bathymetry was the strongest environmental predictor for all models and showed increasing suitability as ocean floor depth decreased, with salinity ranking the second strongest predictor for models that used native and both native and non-native occurrences, indicating low habitat suitability for salinities model results also suggest that red lionfish could continue to invade southern latitudes in the western Atlantic Ocean and may establish localized populations in the eastern Pacific Ocean. We reiterate the importance in the choice of the training data source (native, non-native, or native/non-native) used to develop correlative species distribution models for invasive species.

  13. A dynamic model of oxygen transport from capillaries to tissue with moving red blood cells.

    Science.gov (United States)

    Lücker, Adrien; Weber, Bruno; Jenny, Patrick

    2015-02-01

    Most oxygen required to support the energy needs of vertebrate tissues is delivered by diffusion from microvessels. The presence of red blood cells (RBCs) makes blood flow in the microcirculation highly heterogeneous. Additionally, flow regulation mechanisms dynamically respond to changes in tissue energy demand. These spatiotemporal variations directly affect the supply of oxygen to parenchymal cells. Due to various limiting assumptions, current models of oxygen transport cannot fully capture the consequences of complex hemodynamic effects on tissue oxygenation and are often not suitable for studying unsteady phenomena. With our new approach based on moving RBCs, the impact of blood flow heterogeneity on oxygen partial pressure (Po2) in the tissue can be quantified. Oxygen transport was simulated using parachute-shaped solid RBCs flowing through a capillary. With the use of a conical tissue domain with radii 19 and 13 μm, respectively, our computations indicate that Po2 at the RBC membrane exceeds Po2 between RBCs by 30 mmHg on average and that the mean plasma Po2 decreases by 9 mmHg over 50 μm. These results reproduce well recent intravascular Po2 measurements in the rodent brain. We also demonstrate that instantaneous variations of capillary hematocrit cause associated fluctuations of tissue Po2. Furthermore, our results suggest that homogeneous tissue oxygenation requires capillary networks to be denser on venular side than on arteriolar side. Our new model for oxygen transport will make it possible to quantify in detail the effects of blood flow heterogeneity on tissue oxygenation in realistic capillary networks. Copyright © 2015 the American Physiological Society.

  14. Red clump stars and Gaia: calibration of the standard candle using a hierarchical probabilistic model

    Science.gov (United States)

    Hawkins, Keith; Leistedt, Boris; Bovy, Jo; Hogg, David W.

    2017-10-01

    Distances to individual stars in our own Galaxy are critical in order to piece together the nature of its velocity and spatial structure. Core helium burning red clump (RC) stars have similar luminosities, are abundant throughout the Galaxy and thus constitute good standard candles. We build a hierarchical probabilistic model to quantify the quality of RC stars as standard candles using parallax measurements from the first Gaia data release. A unique aspect of our methodology is to fully account for (and marginalize over) parallax, photometry and dust correction uncertainties, which lead to more robust results than standard approaches. We determine the absolute magnitude and intrinsic dispersion of the RC in 2MASS bands J, H, Ks, Gaia G band and WISE bands W1, W2, W3 and W4. We find that the absolute magnitude of the RC is -1.61 ± 0.01 (in Ks), +0.44 ± 0.01 (in G), -0.93 ± 0.01 (in J), -1.46 ± 0.01 (in H), -1.68 ± 0.02 (in W1), -1.69 ± 0.02 (in W2), -1.67 ± 0.02 (in W3) and -1.76 ± 0.01 mag (in W4). The mean intrinsic dispersion is ˜0.17 ± 0.03 mag across all bands (yielding a typical distance precision of ˜8 per cent). Thus RC stars are reliable and precise standard candles. In addition, we have also re-calibrated the zero-point of the absolute magnitude of the RC in each band, which provides a benchmark for future studies to estimate distances to RC stars. Finally, the parallax error shrinkage in the hierarchical model outlined in this work can be used to obtain more precise parallaxes than Gaia for the most distant RC stars across the Galaxy.

  15. Note on the name of king Narmer

    Directory of Open Access Journals (Sweden)

    Gabor Takacs

    1997-12-01

    Full Text Available The name of Narmer (n'r-mr, king of Upper Egypt in the late predynastic period (ab. 3000 B. C., has remained a mystery for long millennia. The first component of the name is clearly identical with n'r "Weis (catfish" (OK, Med., Gr., Wb II 209, 2-6. But the second element -mr has so far been lacking a reliable and convincing etymological explanation on the Egyptian lexical material. In this brief paper we attempt to give a solution for the second component of the name in the Common Afrasian (Semito-Hamitic lexical material. First, we can also admit that the Egyptian vocabulary does not help too much to clarify -mr, as there is no Egyptian word to fit in the name.

  16. Assessment of value creation in private equity: the acquisition of Burger King by 3G Capital

    OpenAIRE

    Hoene, Daniel Jobst Elmar

    2016-01-01

    This thesis elaborates the creation of value in private equity and in particular analyzes value creation in 3G Capital’s acquisition of Burger King. In this sense, a specific model is applied that composes value creation into several drivers, in order to answer the question of how value creation can be addressed in private equity investments. Although previous research by Achleitner et al. (2010) introduced a specific model that addresses value creation in private equity, the r...

  17. Phreatic explosions during basaltic fissure eruptions: Kings Bowl lava field, Snake River Plain, USA

    Science.gov (United States)

    Hughes, Scott S.; Kobs Nawotniak, Shannon E.; Sears, Derek W. G.; Borg, Christian; Garry, William Brent; Christiansen, Eric H.; Haberle, Christopher W.; Lim, Darlene S. S.; Heldmann, Jennifer L.

    2018-02-01

    Physical and compositional measurements are made at the 7 km-long ( 2200 years B.P.) Kings Bowl basaltic fissure system and surrounding lava field in order to further understand the interaction of fissure-fed lavas with phreatic explosive events. These assessments are intended to elucidate the cause and potential for hazards associated with phreatic phases that occur during basaltic fissure eruptions. In the present paper we focus on a general understanding of the geological history of the site. We utilize geospatial analysis of lava surfaces, lithologic and geochemical signatures of lava flows and explosively ejected blocks, and surveys via ground observation and remote sensing. Lithologic and geochemical signatures readily distinguish between Kings Bowl and underlying pre-Kings Bowl lava flows, both of which comprise phreatic ejecta from the Kings Bowl fissure. These basalt types, as well as neighboring lava flows from the contemporaneous Wapi lava field and the older Inferno Chasm vent and outflow channel, fall compositionally within the framework of eastern Snake River Plain olivine tholeiites. Total volume of lava in the Kings Bowl field is estimated to be 0.0125 km3, compared to a previous estimate of 0.005 km3. The main (central) lava lake lost a total of 0.0018 km3 of magma by either drain-back into the fissure system or breakout flows from breached levees. Phreatic explosions along the Kings Bowl fissure system occurred after magma supply was cut off, leading to fissure evacuation, and were triggered by magma withdrawal. The fissure system produced multiple phreatic explosions and the main pit is accompanied by others that occur as subordinate pits and linear blast corridors along the fissure. The drop in magma supply and the concomitant influx of groundwater were necessary processes that led to the formation of Kings Bowl and other pits along the fissure. A conceptual model is presented that has relevance to the broader range of low-volume, monogenetic

  18. Supplementation of Korean Red Ginseng improves behavior deviations in animal models of autism

    Directory of Open Access Journals (Sweden)

    Edson Luck T. Gonzales

    2016-02-01

    Full Text Available Background: Autism spectrum disorder (ASD is heterogeneous neurodevelopmental disorders that primarily display social and communication impairments and restricted/repetitive behaviors. ASD prevalence has increased in recent years, yet very limited therapeutic targets and treatments are available to counteract the incapacitating disorder. Korean Red Ginseng (KRG is a popular herbal plant in South Korea known for its wide range of therapeutic effects and nutritional benefits and has recently been gaining great scientific attention, particularly for its positive effects in the central nervous system. Objectives: Thus, in this study, we investigated the therapeutic potential of KRG in alleviating the neurobehavioral deficits found in the valproic acid (VPA-exposed mice models of ASD. Design: Starting at 21 days old (P21, VPA-exposed mice were given daily oral administrations of KRG solution (100 or 200 mg/kg until the termination of all experiments. From P28, mice behaviors were assessed in terms of social interaction capacity (P28–29, locomotor activity (P30, repetitive behaviors (P32, short-term spatial working memory (P34, motor coordination (P36, and seizure susceptibility (P38. Results: VPA-exposed mice showed sociability and social novelty preference deficits, hyperactivity, increased repetitive behavior, impaired spatial working memory, slightly affected motor coordination, and high seizure susceptibility. Remarkably, long-term KRG treatment in both dosages normalized all the ASD-related behaviors in VPA-exposed mice, except motor coordination ability. Conclusion: As a food and herbal supplement with various known benefits, KRG demonstrated its therapeutic potential in rescuing abnormal behaviors related to autism caused by prenatal environmental exposure to VPA.

  19. Patterns of referral to Red Cross War Memorial Children's Hospital ...

    African Journals Online (AJOL)

    Health, University of Cape Town and Red Cross War. Memorial Children's Hospital, Cape Town. P. 1. ... and time of arrival and labelled with a standard hospital sticker indicating the name, date of binh, hospital ..... London: King Edward's Hospital Fund fOt London, 1983.' . 10. Technical Management Service, Cape Town ...

  20. Process modeling studies of physical mechanisms of the formation of an anticyclonic eddy in the central Red Sea

    KAUST Repository

    Chen, Changsheng

    2014-02-01

    Surface drifters released in the central Red Sea during April 2010 detected a well-defined anticyclonic eddy around 23°N. This eddy was ∼45–60 km in radius, with a swirl speed up to ∼0.5 m/s. The eddy feature was also evident in monthly averaged sea surface height fields and in current profiles measured on a cross-isobath, shipboard CTD/ADCP survey around that region. The unstructured-grid, Finite-Volume Community Ocean Model (FVCOM) was configured for the Red Sea and process studies were conducted to establish the conditions necessary for the eddy to form and to establish its robustness. The model was capable of reproducing the observed anticyclonic eddy with the same location and size. Diagnosis of model results suggests that the eddy can be formed in a Red Sea that is subject to seasonally varying buoyancy forcing, with no wind, but that its location and structure are significantly altered by wind forcing, initial distribution of water stratification and southward coastal flow from the upstream area. Momentum analysis indicates that the flow field of the eddy was in geostrophic balance, with the baroclinic pressure gradient forcing about the same order of magnitude as the surface pressure gradient forcing.

  1. Modelling phenotypic flexibility : an optimality analysis of gizzard size in Red Knots Calidris canutus

    NARCIS (Netherlands)

    van Gils, Jan A.; Piersma, Theunis; Dekinga, Anne; Battley, Phil F.

    2006-01-01

    Reversible phenotypic changes, such as those observed in nutritional organs of long-distance migrants, increasingly receive the attention of ornithologists. In this paper we review the cost-benefit studies that have been performed on the flexible gizzard of Red Knots Calidris cunutus. By varying the

  2. Modelling phenotypic flexibility: an optimality analysis of gizzard size in Red Knots (Calidris canutus)

    NARCIS (Netherlands)

    Van Gils, J.A.; Piersma, T.; Dekinga, A.; Battley, P.F.

    2006-01-01

    Reversible phenotypic changes, such as those observed in nutritional organs of long-distance migrants, increasingly receive the attention of ornithologists. In this paper we review the cost-benefit studies that have been performed on the flexible gizzard of Red Knots Calidris canutus. By varying the

  3. Red Orange: Experimental Models and Epidemiological Evidence of Its Benefits on Human Health

    Directory of Open Access Journals (Sweden)

    Giuseppe Grosso

    2013-01-01

    Full Text Available In recent years, there has been increasing public interest in plant antioxidants, thanks to the potential anticarcinogenic and cardioprotective actions mediated by their biochemical properties. The red (or blood orange (Citrus sinensis (L. Osbeck is a pigmented sweet orange variety typical of eastern Sicily (southern Italy, California, and Spain. In this paper, we discuss the main health-related properties of the red orange that include anticancer, anti-inflammatory, and cardiovascular protection activities. Moreover, the effects on health of its main constituents (namely, flavonoids, carotenoids, ascorbic acid, hydroxycinnamic acids, and anthocyanins are described. The red orange juice demonstrates an important antioxidant activity by modulating many antioxidant enzyme systems that efficiently counteract the oxidative damage which may play an important role in the etiology of numerous diseases, such as atherosclerosis, diabetes, and cancer. The beneficial effects of this fruit may be mediated by the synergic effects of its compounds. Thus, the supply of natural antioxidant compounds through a balanced diet rich in red oranges might provide protection against oxidative damage under differing conditions and could be more effective than, the supplementation of an individual antioxidant.

  4. Red orange: experimental models and epidemiological evidence of its benefits on human health.

    Science.gov (United States)

    Grosso, Giuseppe; Galvano, Fabio; Mistretta, Antonio; Marventano, Stefano; Nolfo, Francesca; Calabrese, Giorgio; Buscemi, Silvio; Drago, Filippo; Veronesi, Umberto; Scuderi, Alessandro

    2013-01-01

    In recent years, there has been increasing public interest in plant antioxidants, thanks to the potential anticarcinogenic and cardioprotective actions mediated by their biochemical properties. The red (or blood) orange (Citrus sinensis (L.) Osbeck) is a pigmented sweet orange variety typical of eastern Sicily (southern Italy), California, and Spain. In this paper, we discuss the main health-related properties of the red orange that include anticancer, anti-inflammatory, and cardiovascular protection activities. Moreover, the effects on health of its main constituents (namely, flavonoids, carotenoids, ascorbic acid, hydroxycinnamic acids, and anthocyanins) are described. The red orange juice demonstrates an important antioxidant activity by modulating many antioxidant enzyme systems that efficiently counteract the oxidative damage which may play an important role in the etiology of numerous diseases, such as atherosclerosis, diabetes, and cancer. The beneficial effects of this fruit may be mediated by the synergic effects of its compounds. Thus, the supply of natural antioxidant compounds through a balanced diet rich in red oranges might provide protection against oxidative damage under differing conditions and could be more effective than, the supplementation of an individual antioxidant.

  5. A simple model to describe intrinsic stellar noise for exoplanet detection around red giants

    DEFF Research Database (Denmark)

    North, Thomas S. H.; Chaplin, William J.; Gilliland, Ronald L.

    2017-01-01

    In spite of the huge advances in exoplanet research provided by the NASA Kepler Mission, there remain only a small number of transit detections around evolved stars. Here, we present a reformulation of the noise properties of red-giant stars, where the intrinsic stellar granulation and the stellar...

  6. Shear-controlled evolution of the Red Sea: pull apart model

    Science.gov (United States)

    Makris, J.; Rihm, R.

    1991-11-01

    Results of seismic and other geophysical investigations suggest that strike-slip processes controlled the break-up of the Arabian plate from Africa and initiated the Red Sea Rift. Early oceanisation was facilitated by nucleation of pull apart basins and massive intrusives. The evolution of the Red Sea has gone through different stages. It was a zone of structural weakness already during the Pan-African orogeny approximately 600 Ma. A major reactivation, however, that gradually led to the present-day configuration was initiated during the late Oligocene with intense magmatic activity and the development of a continental rift. Wrench faulting played a key role in the early evolution of the Red Sea, as it shaped most of its western flank as a sharp plate boundary and resulted in the generation and rapid oceanisation of linearly arranged pull apart basins. Spatial distribution of these basins reflects the geometry of the strike-slip zone, which was controlled by pre-existing fault systems like the Najd Shear System, the Central African Fault Zone or the Onib-Hamisana and Baraka suture zones. Strike-slip motion along the latter zones of weakness influenced mainly the Egyptian and Sudanese coastal areas. Arabia was therefore separated from Africa by oceanisation in those regions, where pull apart basins developed. They were still connected in the in-between segments by stretched continental crust. With Arabia as the "moving" and Africa as the "stable" plate the eastern Red Sea flank was formed by pure shear through stretching, thinning and diffuse extension. As a consequence, the eastern and western flanks of the Red Sea are asymmetrical. The acceleration of the movement of Arabia in early/middle Miocene could no longer be accommodated by the opening in the Gulf of Suez and consequently the Dead Sea strike-slip fault developed approximately 14 Ma ago. Since plate motion was still oblique to the major structural trends, the pull apart evolution on the western flank

  7. Contribution of King Njoya to Bamoun traditional medicine through ...

    African Journals Online (AJOL)

    National Coordinator of the Census of Traditional Healers of Cameroon" presented the list of Tradipractitioners who were probably King Njoya's students and examined their current heritage and contribution to African Traditional Medicine.

  8. King County Metro Transit Hybrid Articulated Buses: Final Evaluation Results

    Energy Technology Data Exchange (ETDEWEB)

    Chandler, K.; Walkowicz, K.

    2006-12-01

    Final technical report compares and evaluates new diesel and diesel hybrid-electric articulated buses operated as part of the King County Metro Transit (KC Metro) fleet in Seattle, Washington. The evaluation lasted 12 months.

  9. AFSC/RACE/SAP/Urban: Golden King Crab tagging

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data is comprised of the records of individual male golden king crab (GKC) tagged at the Kodiak Laboratory. Initial size, shell condition and missing limbs was...

  10. Reflections on Cambridge: John Maynard Keynes at King's College Cambridge

    OpenAIRE

    Macfarlane, Alan

    2012-01-01

    .mp4 video file The economist John Maynard Keynes spent much of his life in Cambridge, connected to King's College. Alan Macfarlane reflects on a few aspects of his life and work. Filmed by Xu Bei in 2010

  11. Direct somatic embryogenesis in Swietenia macrophylla King

    Directory of Open Access Journals (Sweden)

    Raúl Collado

    2006-04-01

    Full Text Available Swietenia macrophylla King is difficult to be propagated by tissue culture and there is not an efficient system via organogenesis, due to problems of microbial contamination, phenolic oxidation and death of tissue in the phase of in vitro establishment of explants. In order to establish a protocol for obtaining somatic embryos, zygotic embryos were used as initial plant material. Three combinations of 2,4-D with kinetin were studied, to obtain the formation of somatic embryos. After six weeks of culture, the number of explants with high and low somatic embryogenesis frequency were determined. So that the somatic embryos in globular stage reach the final stages of torpedo and cotyledonal, these were placed in three treatments with 6-BAP (0.2, 0.4 y 0.6 mg.l-1. The number of somatic embryos that reached the torpedo and cotyledonal stages were evaluated after 30 days of culture. Results demonstrated that direct somatic embryogenesis from immature zygotic embryos is obtained in the culture medium composed by MS salts with 4.0 mg.l-1 of 2,4-D and 1.0 mg.l-1 of kinetin. Higher percentage of somatic embryos in cotiledonal stage (91.7 %, was obtained with 0.4 mg.l-1 of 6-BAP. Key word: forestry, growth regulator, mahogany, somatic embryo, tissue culture

  12. The King's College Hospital Acute Stroke Unit.

    Science.gov (United States)

    Bath, P; Butterworth, R J; Soo, J; Kerr, J E

    1996-01-01

    The King's College Hospital (KCH) Acute Stroke Unit (ASU) was set up in January 1994 in order to provide acute management for patients admitted with stroke and to undertake biomedical research. Of 206 patients admitted to KCH with a stroke or suffering an in-hospital stroke, 141 (68%) patients were admitted to the ASU over its first 6 months of operation: 120 (85%) were from the Accident and Emergency Department and 21 (15%) from other wards. Management included resuscitation and medical stabilisation, investigation, prevention of stroke complications (including aspiration, venous thrombosis, and pressure sores), rehabilitation (physiotherapy, occupational therapy, speech and language therapy), nutrition (dietetics) and initiation of secondary prevention measures (aspirin or anticoagulation, blood pressure and lipid lowering, and carotid endarterectomy). All aspects of management are driven by agreed guidelines. Patients remain under the care of the admitting physician but specific stroke management and guidance is provided by two research doctors and the unit's nurses, therapists and dietician. The unit also facilitates research into stroke pathophysiology and acute therapeutic interventions. Our experience suggests that an ASU is relatively easy to set up and may contribute to improved care. Whether ASUs improve patient survival and functional outcome, and are cost-effective, requires further study.

  13. Translating the Old Testament: Learning from the King James Bible

    OpenAIRE

    Robson, J

    2016-01-01

    The Hebrew word "dabar" is translated in the King James Bible by no fewer than 82 different English words. This article explores how and why it is translated like this, considering some of the issues at stake in Bible translation more generally, and with the King James Bible, in particular. It examines more closely six ways in which translation decisions either affect interpretation or reveal the translation process. It draws out implications for translators, readers, and for evaluating th...

  14. The medico-psychological interests of King James I.

    Science.gov (United States)

    Pady, D S

    1984-01-01

    King James I of England (1566-1625) had unusually wide interests in new concepts about mental and physical diseases during the early seventeenth-century. He issued medical opinions about magic, witchcraft, the bubonic plague, hysteria, unconscious fits, sleepwalking, smoking, the "King's Evil", and many other medico-psychological symptoms and treatments which caught his imagination. In his didactic way, James's continuing studies of medical abnormalities of the body and mind revealed his great concern about the health of his people.

  15. Filtering remotely sensed chlorophyll concentrations in the Red Sea using a space-time covariance model and a Kalman filter

    KAUST Repository

    Dreano, Denis

    2015-04-27

    A statistical model is proposed to filter satellite-derived chlorophyll concentration from the Red Sea, and to predict future chlorophyll concentrations. The seasonal trend is first estimated after filling missing chlorophyll data using an Empirical Orthogonal Function (EOF)-based algorithm (Data Interpolation EOF). The anomalies are then modeled as a stationary Gaussian process. A method proposed by Gneiting (2002) is used to construct positive-definite space-time covariance models for this process. After choosing an appropriate statistical model and identifying its parameters, Kriging is applied in the space-time domain to make a one step ahead prediction of the anomalies. The latter serves as the prediction model of a reduced-order Kalman filter, which is applied to assimilate and predict future chlorophyll concentrations. The proposed method decreases the root mean square (RMS) prediction error by about 11% compared with the seasonal average.

  16. Human resources managers as custodians of the King III code

    Directory of Open Access Journals (Sweden)

    Frank de Beer

    2015-05-01

    Full Text Available The objective of this research was to perform an exploratory study on the knowledge and understanding of the King III code among Human Resources (HR managers in South African companies. The King III code is a comprehensive international corporate governance regime which addresses the financial, social, ethical and environmental practices of organisations. HR management plays a role in managing corporate governance by using the King III code as a guideline. The main research questions were: Does HR management know, understand, apply, and have the ability to use the King III code in terms of ethical decision-making? What role does HR management play in corporate governance? A random sample of available HR managers, senior HR consultants and HR directors was taken and semi-structured interviews were conducted. The results indicated that the respondents had no in-depth knowledge of the King III code. They did not fully understand the King III code and its implications nor did they use it to ensure ethical management. The themes most emphasised by the participants were: culture, reward and remuneration, policies and procedures and performance management. The participants emphasised the importance of these items  and HR’s role in managing them.

  17. Arterial roads and area socioeconomic status are predictors of fast food restaurant density in King County, WA

    Directory of Open Access Journals (Sweden)

    Streichert Laura C

    2009-07-01

    Full Text Available Abstract Background Fast food restaurants reportedly target specific populations by locating in lower-income and in minority neighborhoods. Physical proximity to fast food restaurants has been associated with higher obesity rates. Objective To examine possible associations, at the census tract level, between area demographics, arterial road density, and fast food restaurant density in King County, WA, USA. Methods Data on median household incomes, property values, and race/ethnicity were obtained from King County and from US Census data. Fast food restaurant addresses were obtained from Public Health-Seattle & King County and were geocoded. Fast food density was expressed per tract unit area and per capita. Arterial road density was a measure of vehicular and pedestrian access. Multivariate logistic regression models containing both socioeconomic status and road density were used in data analyses. Results Over one half (53.1% of King County census tracts had at least one fast food restaurant. Mean network distance from dwelling units to a fast food restaurant countywide was 1.40 km, and 1.07 km for census tracts containing at least one fast food restaurant. Fast food restaurant density was significantly associated in regression models with low median household income (p Conclusion No significant association was observed between census tract minority status and fast food density in King County. Although restaurant density was linked to low household incomes, that effect was attenuated by arterial road density. Fast food restaurants in King County are more likely to be located in lower income neighborhoods and higher traffic areas.

  18. Racism and the older voter? Arizona's rejection of a paid holiday to honor Martin Luther King.

    Science.gov (United States)

    Kastenbaum, R

    1991-01-01

    Two propositions that would have established a paid Martin Luther King holiday were defeated in Arizona's statewide elections of November 6, 1990. Communities and counties with high proportions of senior adult voters cast proportionately more votes against these propositions. Was this an example of racism among the primarily anglo senior adult voters of Arizona? Three models were proposed to account for the general pattern of election-related behavior as well as the vote itself: 1) proactive racist, 2) pragmatic self-interest, and 3) fortress mentality. It was suggested that proactive racism and pragmatic self-interest accounted for less of the opposition to a paid holiday honoring Martin Luther King than did a fortress mentality that has developed through a combination of circumstances. Attention is also given to the larger question of senior adults as perpetrators as well as victims of bigotry.

  19. Using LiDAR datasets to improve HSPF water quality modeling in the Red River of the North Basin

    Science.gov (United States)

    Burke, M. P.; Foreman, C. S.

    2013-12-01

    The Red River of the North Basin (RRB), located in the lakebed of ancient glacial Lake Agassiz, comprises one of the flattest landscapes in North America. The topography of the basin, coupled with the Red River's direction of flow from south to north results in a system that is highly susceptible to flooding. The magnitude and frequency of flood events in the RRB has prompted several multijurisdictional projects and mitigation efforts. In response to the devastating 1997 flood, an International Joint Commission sponsored task force established the need for accurate elevation data to help improve flood forecasting and better understand risks. This led to the International Water Institute's Red River Basin Mapping Initiative, and the acquisition LiDAR Data for the entire US portion of the RRB. The resulting 1 meter bare earth digital elevation models have been used to improve hydraulic and hydrologic modeling within the RRB, with focus on flood prediction and mitigation. More recently, these LiDAR datasets have been incorporated into Hydrological Simulation Program-FORTRAN (HSPF) model applications to improve water quality predictions in the MN portion of the RRB. RESPEC is currently building HSPF model applications for five of MN's 8-digit HUC watersheds draining to the Red River, including: the Red Lake River, Clearwater River, Sandhill River, Two Rivers, and Tamarac River watersheds. This work is being conducted for the Minnesota Pollution Control Agency (MPCA) as part of MN's statewide watershed approach to restoring and protecting water. The HSPF model applications simulate hydrology (discharge, stage), as well as a number of water quality constituents (sediment, temperature, organic and inorganic nitrogen, total ammonia, organic and inorganic phosphorus, dissolved oxygen and biochemical oxygen demand, and algae) continuously for the period 1995-2009 and are formulated to provide predictions at points of interest within the watersheds, such as observation gages

  20. Integration of Long-Term Research into a GIS Based Landscape Habitat Model for the Red-Cockaded Woodpecker

    Energy Technology Data Exchange (ETDEWEB)

    Franzreb, K.; Lloyd, F.T.

    2000-10-01

    The red cockaded woodpecker has been intensively studied since 1985 when the population was on the verge of extinction. The population decline is primarily the result of timber harvesting prior to 1950 and restricted burning. Construction of artificial cavities, translocations, competitor control, and removal of hardwood mid-story has provided suitable habitat. Since 1985, the population has increased from 4 to 99 birds. A GIS model is being developed to simulate the development of habitat at SRS in relation to management and existing vegetation.

  1. High-resolution regional modeling of summertime transport and impact of African dust over the Red Sea and Arabian Peninsula

    KAUST Repository

    Kalenderski, Stoitchko Dimitrov

    2016-05-23

    Severe dust outbreaks and high dust loading over Eastern Africa and the Red Sea are frequently detected in the summer season. Observations suggest that small-scale dynamic and orographic effects, from both the Arabian and African sides, strongly contribute to dust plume formation. To better understand these processes, we present here the first high resolution modeling study of a dust outbreak in June 2012 developed over East Africa, the Red Sea, and the Arabian Peninsula. Using the Weather Research and Forecasting model coupled with Chemistry component (WRF-Chem), we identified several dust generating dynamical processes that range from convective to synoptic scales, including synoptic cyclones, nocturnal low-level jets, and cold pools of mesoscale convective systems. The simulations reveal an eastward transport of African dust across the Red Sea. Over the northern part of the Red Sea, most of the dust transport occurs above 2 km height, whereas across the central and southern parts of the sea, dust is mostly transported below 2 km height. Dust is the dominant contributor (87%) to the aerosol optical depth, producing a domain average cooling effect of -12.1 W m-2 at the surface, a warming of 7.1 W m-2 in the atmosphere, and a residual cooling of -4.9 W m-2 at the top of the atmosphere. Both dry and wet deposition processes contribute significantly to dust removal from the atmosphere. Model results compare well with available ground-based and satellite observations, but generally underestimate the observed maximum values of aerosol optical depth. The satellite-retrieved mean optical depth at some locations are underestimated by a factor of two. A sensitive experiment suggests that these large local differences may result from poor characterization of dust emissions in some areas of the modeled domain. In this case study we successfully simulate the major fine-scale dust generating dynamical processes, explicitly resolving convection and haboob

  2. The 'Byzantinisms' of king Stefan Radoslav

    Directory of Open Access Journals (Sweden)

    Maksimović Ljubomir

    2009-01-01

    Full Text Available The life-style and politics of Stefan Radoslav bear the mark of activities that indicated his special attachment to the Byzantine world. These activities were prompted by a combination of ideological ambitions and political reality, but they were not in keeping with the modest achievements of Radoslav's reign. Moreover, most of these activities belong to the time when Radoslav was heir to the throne. There is no doubt that Stefan Nemanjić the Grand Zhupan and subsequently the first crowned king, had exclusive connections with the Byzantine dynasty of the Angeloi, especially with the emperor Alexios III (1195-1203. In that context, the donor's inscription in the basic ring of the dome in the Church of the Mother of God in Studenica (1208, in which his father Stefan Nemanja, is mentioned as (former 'veleslavni gospodin vse srbske zemlje veli(ki župan i svat cara grčkog kir Alesija', is quite indicative. This ideological construction would acquire a contour in reality by means of a political marriage with one of the female offspring of Angeloi lineage, which would represent an alternative solution to Stefan's failed marriage with Eudocia, daughter of the emperor Alexios. Instead, several years elapsed in waging war with the Latins, the Bulgarians and the State of Epiros. However, efforts to create firmer, more tangible ties with the Angeloi dynasty from Epiros were not forgotten. Therefore, the Serbian monarch brought his eldest son Radoslav into play, intending to have him act as a link with the Angeloi bloodline. As a result of all this, the final attempt to have Radoslav become the husband of a princess from the Angelos dynasty is not surprising. At the end of 1219 or the beginning of 1220, he married Anna Doukaina, the daughter of the epirotic ruler Theodore I Angelos Doukas Komnenos, which at that point represented a marriage connection of the highest possible level between two ruling houses. Stefan's insistence on Serbia acquiring a stake

  3. Correction to Kreuzbauer, King, and Basu (2015).

    Science.gov (United States)

    2015-08-01

    Reports an error in "The Mind in the Object-Psychological Valuation of Materialized Human Expression" by Robert Kreuzbauer, Dan King and Shankha Basu (Journal of Experimental Psychology: General, Advanced Online Publication, Jun 15, 2015, np). In the article the labels on the X-axis of Figure 1 "Remove Variance" and "Preserve Variance" should be switched. (The following abstract of the original article appeared in record 2015-26264-001.) Symbolic material objects such as art or certain artifacts (e.g., fine pottery, jewelry) share one common element: The combination of generating an expression, and the materialization of this expression in the object. This explains why people place a much greater value on handmade over machine-made objects, and originals over duplicates. We show that this mechanism occurs when a material object's symbolic property is salient and when the creator (artist or craftsman) is perceived to have agency control over the 1-to-1 materialized expression in the object. Coactivation of these 2 factors causes the object to be perceived as having high value because it is seen as the embodied representation of the creator's unique personal expression. In 6 experiments, subjects rated objects in various object categories, which varied on the type of object property (symbolic, functional, aesthetic), the production procedure (handmade, machine-made, analog, digital) and the origin of the symbolic information (person or software). The studies showed that the proposed mechanism applies to symbolic, but not to functional or aesthetic material objects. Furthermore, they show that this specific form of symbolic object valuation could not be explained by various other related psychological theories (e.g., uniqueness, scarcity, physical touching, creative performance). Our research provides a universal framework that identifies a core mechanism for explaining judgments of value for one of our most uniquely human symbolic object categories. (c) 2015 APA, all

  4. C. Judson King of UC Berkeley

    Energy Technology Data Exchange (ETDEWEB)

    Prausnitz, John

    2005-06-01

    In the middle of the UC Berkeley campus, next to the Main Library, South Hall is the last surviving building from the original campus, founded about 135 years ago. A tiny tree-shaded appendix to this venerated classical building houses Berkeley's Center for Studies in Higher Education, directed by C. Judson King, former Provost and Senior Vice President--Academic Affairs of the ten-campus University of California and long-time Professor of Chemical Engineering at Berkeley. Jud came to Berkeley in 1963 as assistant professor of chemical engineering, following receipt of a doctor's degree from MIT and a subsequent short appointment as director of the MIT chemical engineering practice school station at what was then Esso (now Exxon) in New Jersey. His undergraduate degree is from Yale. Starting with his MIT doctoral dissertation on gas absorption, Jud has devoted much of his professional career to separation processes. His teaching and research activities have been primarily concerned with separation of mixtures with emphasis on liquid-liquid extraction and drying. As a consultant to Procter and Gamble, he contributed to the technology of making instant coffee. His life-long activities in hiking and camping stimulated Jud's interest in the manufacture of freeze-dried foods (e.g. turkey meat) to minimize the weight of his hiking back-pack. Jud is internationally known not only for his many research publications but even more, for his acclaimed textbook ''Separation Processses'' (McGraw-Hill, second edition 1980) that is used in standard chemical engineering courses in the US and abroad.

  5. Primary hyperparathyroidism: King Khalid University Hospital experience

    International Nuclear Information System (INIS)

    Fouda, Mona A.

    1999-01-01

    This study was conducted to examine the prevalence, mode of presentationand management of primary hyperparathyroidism in one of the major hospitalsin Saudi Arabia. This was a retrospective analysis of 24 cases of primaryhyperparathyroidism comprising of 21 females and three males, who were seenat King Khalid University Hospital over a period of 16 years from 1982 untilDecember 1997. The prevalence of disease was estimated to be estimated to be11.34 per 100,000 hospital population. The majority of patients presentedwith musculoskeletal complaints (62%-67%) and/or renal complications were(58%). Hyperclacemia was seen in 92% of the cases. Serum PTH was availablefor 21 patients and 20 had significantly elevated levels. Fifty percent ofthe patients had features of hyperparathyroid bone disease on plane x-ray,while 79% showed osteopenia of the femoral neck and dual x-rayabsorptiometry, and almost all the patients had lumbar osteopenia. Fiftypercent of the patients had features of metabolic bone disease on bone scan.Thallium -technetium subtraction studies proved to be the most reliable tool,with 83% sensitivity of 55%. CT scan of the neck was attempted in only inseven patients (29%), with a sensitivity of 86%. Twenty-one patients (87.5%)underwent surgical exploration and removal of the parathyroid adenoma. Singleparathyroid adenoma was identified in 85% of the cases, 5% had multipleadenomas and 5% had hyperplasia of the parathyroid gland. Our results showedthat primary hyperparathyroidism is not rare disease in Saudi Arabia. It hastendency for late presentation with complications. We believe that routinescreening for calcium, and early identification of such cases, are warrantedto reduce the morbidity of this easily treatable disorder. (author)

  6. Kinetic modeling of liquid-phase adsorption of Congo red dye using guava leaf-based activated carbon

    Science.gov (United States)

    Ojedokun, Adedamola Titi; Bello, Olugbenga Solomon

    2017-07-01

    Guava leaf, a waste material, was treated and activated to prepare adsorbent. The adsorbent was characterized using Scanning Electron Microscopy (SEM), Fourier Transform Infra Red (FTIR) and Energy-Dispersive X-ray (EDX) techniques. The carbonaceous adsorbent prepared from guava leaf had appreciable carbon content (86.84 %). The adsorption of Congo red dye onto guava leaf-based activated carbon (GLAC) was studied in this research. Experimental data were analyzed by four different model equations: Langmuir, Freundlich, Temkin and Dubinin-Radushkevich isotherms and it was found to fit Freundlich equation most. Adsorption rate constants were determined using pseudo-first-order, pseudo-second-order, Elovich and intraparticle diffusion model equations. The results clearly showed that the adsorption of CR dye onto GLAC followed pseudo-second-order kinetic model. Intraparticle diffusion was involved in the adsorption process. The mean energy of adsorption calculated from D-R isotherm confirmed the involvement of physical adsorption. Thermodynamic parameters were obtained and it was found that the adsorption of CR dye onto GLAC was an exothermic and spontaneous process at the temperatures under investigation. The maximum adsorption of CR dye by GLAC was found to be 47.62 mg/g. The study shows that GLAC is an effective adsorbent for the adsorption of CR dye from aqueous solution.

  7. A Novel Physiology-Based Mathematical Model to Estimate Red Blood Cell Lifespan in Different Human Age Groups.

    Science.gov (United States)

    An, Guohua; Widness, John A; Mock, Donald M; Veng-Pedersen, Peter

    2016-09-01

    Direct measurement of red blood cell (RBC) survival in humans has improved from the original accurate but limited differential agglutination technique to the current reliable, safe, and accurate biotin method. Despite this, all of these methods are time consuming and require blood sampling over several months to determine the RBC lifespan. For situations in which RBC survival information must be obtained quickly, these methods are not suitable. With the exception of adults and infants, RBC survival has not been extensively investigated in other age groups. To address this need, we developed a novel, physiology-based mathematical model that quickly estimates RBC lifespan in healthy individuals at any age. The model is based on the assumption that the total number of RBC recirculations during the lifespan of each RBC (denoted by N max) is relatively constant for all age groups. The model was initially validated using the data from our prior infant and adult biotin-labeled red blood cell studies and then extended to the other age groups. The model generated the following estimated RBC lifespans in 2-year-old, 5-year-old, 8-year-old, and 10-year-old children: 62, 74, 82, and 86 days, respectively. We speculate that this model has useful clinical applications. For example, HbA1c testing is not reliable in identifying children with diabetes because HbA1c is directly affected by RBC lifespan. Because our model can estimate RBC lifespan in children at any age, corrections to HbA1c values based on the model-generated RBC lifespan could improve diabetes diagnosis as well as therapy in children.

  8. Nile red nanosuspensions as investigative model to study the follicular targeting of drug nanocrystals.

    Science.gov (United States)

    Corrias, Francesco; Schlich, Michele; Sinico, Chiara; Pireddu, Rosa; Valenti, Donatella; Fadda, Anna Maria; Marceddu, Salvatore; Lai, Francesco

    2017-05-30

    The strategy of formulating poorly soluble actives as nanosuspension has been explored by more than a thousand research papers, with some medicinal products for oral and intravenous use having reached the market or advanced clinical trials. Interestingly, there is a limited number of reports of nanosuspensions formulated for dermal and transdermal drug delivery. In the present work, a nanocrystals suspension of the fluorescent, water-insoluble dye Nile Red, is prepared through a media milling technique and exploited to characterize the fate of the nanosuspended drug when applied on the skin. More in detail, the accumulation of Nile Red nanocrystals inside the hair follicles is evidenced by scanning electron microscopy, and the diffusion of drug molecules in the different skin layers is evaluated by confocal microscopy and skin permeation studies. Overall, the combination of the analytical techniques provide a description of the mechanisms underlying dermal accumulation, and transdermal penetration of a drug formulated as a nanosuspension. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Menu-labeling policy in King County, Washington.

    Science.gov (United States)

    Johnson, Donna B; Payne, Elizabeth C; McNeese, Molly A; Allen, Deborah

    2012-09-01

    Food eaten away from home now accounts for about one third of total calories consumed in the U.S. Policy change could lead to sustainable improvements in restaurant and other nutrition environments. Broadly described, policy development is one of the three core functions of public health, and there is a need to more fully understand and evaluate this function. Policy process research has developed frameworks and models that can be used to understand the policy development process. To describe policy processes associated with the passage of restaurant menu-labeling regulations in order to inform nutrition policy development in other settings. Document reviews and interviews with 12 key players in the policy process were conducted and analyzed between June 2009 and October 2010. Policy process actors primarily belonged to two advocacy coalitions: a public health coalition and an industry coalition. Within the coalitions there were shared values and beliefs about the appropriate role of governmental regulation in protecting the health of the population and the need for environmental change. The process was adversarial at times, but "policy learning" built the trust needed for collaboration to negotiate agreements. Expert technical assistance moved the process forward. Elements that contributed to the success of a menu-labeling policy initiative in a large, urban health department have been identified. The King County case study can inform the work of others who seek to build healthier nutrition environments through policy change. Copyright © 2012 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

  10. Beat characteristics and beat maps of the King Seong-deok Divine Bell

    Science.gov (United States)

    Kim, Seock-Hyun; Lee, Chi-Wook; Lee, Jang-Moo

    2005-03-01

    King Seong-deok Divine Bell is the second oldest bell in Korea. The bell is considered to have the best sound quality among Korean bells. The beat phenomenon is one of the most important characteristics for the sound of the King Seong-deok Divine Bell. In this study, the relationships between the modal parameters and the peculiar beat phenomena of the bell are investigated. It is theoretically proved from the beat characteristics that the sound might indeed be heard differently depending on the listening positions. The beat map method is introduced to visualize the beat distribution properties. It is shown that the beat maps can be drawn with a theoretical model based on the modal data of the bell. Using the beat maps of the King Seong-deok Divine Bell, it is investigated why clear and unclear beats, large and small amplitudes of the vibrations are repeated periodically along the circumference of the bell. Furthermore, the effect of the striking position on the beat distribution property is examined systematically.

  11. Structural equation model of total phosphorus loads in the Red River of the North Basin, USA and Canada

    Science.gov (United States)

    Ryberg, Karen R.

    2017-01-01

    Attribution of the causes of trends in nutrient loading is often limited to correlation, qualitative reasoning, or references to the work of others. This paper represents efforts to improve causal attribution of water-quality changes. The Red River of the North basin provides a regional test case because of international interest in the reduction of total phosphorus loads and the availability of long-term total phosphorus data and ancillary geospatial data with the potential to explain changes in water quality over time. The objectives of the study are to investigate structural equation modeling methods for application to water-quality problems and to test causal hypotheses related to the drivers of total phosphorus loads over the period 1970 to 2012. Multiple working hypotheses that explain total phosphorus loads and methods for estimating missing ancillary data were developed, and water-quality related challenges to structural equation modeling (including skewed data and scaling issues) were addressed. The model indicates that increased precipitation in season 1 (November–February) or season 2 (March–June) would increase total phosphorus loads in the basin. The effect of agricultural practices on total phosphorus loads was significant, although the effect is about one-third of the effect of season 1 precipitation. The structural equation model representing loads at six sites in the basin shows that climate and agricultural practices explain almost 60% of the annual total phosphorus load in the Red River of the North basin. The modeling process and the unexplained variance highlight the need for better ancillary long-term data for causal assessments.

  12. Soft computing for modeling the value of social capital at Red Hat

    OpenAIRE

    Siderska, Julia

    2014-01-01

    Artykuł finansowany ze stypendium naukowe w ramach projektu Urzędu Marszałkowskiego Województwa Podlaskiego „Stypendia dla doktorantów województwa podlaskiego” finansowanego w ramach Działania 8.2 – Transfer Wiedzy, Poddziałanie 8.2.2 – Regionalne Strategie Innowacji, Priorytet VIII PO KL, współfinansowanego ze środków EFS, budżetu państwa oraz środków budżetu województwa podlaskiego. The main objective of this paper is to predict the value of social capital at Red Hat Corporation, using a...

  13. Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma.

    Science.gov (United States)

    Salari, H; Howard, S; Chan, H; Dryden, P; Chan-Yeung, M

    1994-05-01

    Western red cedar asthma is the most common form of occupational asthma in the Pacific Northwest. Plicatic acid (PA) is the chemical component of Western red cedar that causes asthma. The role of immunologic processes involved in the PA-induced asthmatic reaction has not been established. To characterize the mechanisms of PA-induced asthmatic reaction, guinea pigs were sensitized to PA through biweekly injection of PA-ovalbumin conjugate with aluminum hydroxide as an adjuvant for a period of 6 months. Specific IgG1 antibodies to PA were detected in the blood 3 months after sensitization of animals. The level of specific IgG1 antibodies to ovalbumin after 6 months was about two times the level of specific IgG1 to PA. At 6 months, tracheal tissue from PA-ovalbumin-sensitized guinea pigs contracted after exposure to either PA or ovalbumin in vitro. The degree of contraction induced by PA was two to three times less than the contraction induced by ovalbumin. PA caused histamine, prostaglandin D2, and leukotriene D4 release from both lung mast cells and blood basophils. The amount of histamine and eicosanoids released by PA was also two to three times less than the amount of mediators released by ovalbumin. When the trachea of normal guinea pigs was passively sensitized with serum from PA-ovalbumin-sensitized guinea pigs, it contracted in response to PA or ovalbumin in an organ bath. When the serum of PA-ovalbumin-sensitized guinea pigs was depleted of immunoglobulins and then used for passive sensitization of normal trachea, no contraction was observed when challenged with PA, suggesting that IgG1 antibodies mediate the tracheal reaction to PA.(ABSTRACT TRUNCATED AT 250 WORDS)

  14. Fractional order models of viscoelasticity as an alternative in the analysis of red blood cell (RBC) membrane mechanics.

    Science.gov (United States)

    Craiem, Damian; Magin, Richard L

    2010-01-20

    New lumped-element models of red blood cell mechanics can be constructed using fractional order generalizations of springs and dashpots. Such 'spring-pots' exhibit a fractional order viscoelastic behavior that captures a wide spectrum of experimental results through power-law expressions in both the time and frequency domains. The system dynamics is fully described by linear fractional order differential equations derived from first order stress-strain relationships using the tools of fractional calculus. Changes in the composition or structure of the membrane are conveniently expressed in the fractional order of the model system. This approach provides a concise way to describe and quantify the biomechanical behavior of membranes, cells and tissues.

  15. Fractional order models of viscoelasticity as an alternative in the analysis of red blood cell (RBC) membrane mechanics

    International Nuclear Information System (INIS)

    Craiem, Damian; Magin, Richard L

    2010-01-01

    New lumped-element models of red blood cell mechanics can be constructed using fractional order generalizations of springs and dashpots. Such 'spring-pots' exhibit a fractional order viscoelastic behavior that captures a wide spectrum of experimental results through power-law expressions in both the time and frequency domains. The system dynamics is fully described by linear fractional order differential equations derived from first order stress–strain relationships using the tools of fractional calculus. Changes in the composition or structure of the membrane are conveniently expressed in the fractional order of the model system. This approach provides a concise way to describe and quantify the biomechanical behavior of membranes, cells and tissues. (perspective)

  16. Validation of King's transaction process for healthcare provider-patient communication in pharmaceutical context: One cross-sectional study.

    Science.gov (United States)

    Wang, Dan; Liu, Chenxi; Zhang, Zinan; Ye, Liping; Zhang, Xinping

    2018-03-27

    With the impressive advantages of patient-pharmacist communication being advocated and poor pharmacist-patient communication in different settings, it is of great significance and urgency to explore the mechanism of the pharmacist-patient communicative relationship. The King's theory of goal attainment is proposed as one of the most promising models to be applied, because it takes into consideration both improving the patient-pharmacist relationship and attaining patients' health outcomes. This study aimed to validate the King's transaction process and build the linkage between the transaction process and patient satisfaction in a pharmaceutical context. A cross-sectional study was conducted in four tertiary hospitals in two provincial cities (Wuhan and Shanghai) in central and east China in July 2017. Patients over 18 were investigated in the pharmacies of the hospitals. The instrument for the transaction process was revised and tested. Path analysis was conducted for the King's transaction process and its relationship with patient satisfaction. Five hundred eighty-nine participants were investigated for main study. Prior to the addition of covariates, the hypothesised model of the King's transaction process was validated, in which all paths of the transaction process were statistically significant (p process had direct effects on patient satisfaction (p process was established as one valid theoretical framework of healthcare provider-patient communication in a pharmaceutical context. Copyright © 2018 Elsevier Inc. All rights reserved.

  17. Evolutionary Models of Red Supergiants: Evidence for A Metallicity-dependent Mixing Length and Implications for Type IIP Supernova Progenitors

    Science.gov (United States)

    Chun, Sang-Hyun; Yoon, Sung-Chul; Jung, Moo-Keon; Kim, Dong Uk; Kim, Jihoon

    2018-01-01

    Recent studies on the temperatures of red supergiants (RSGs) in the local universe provide us with an excellent observational constraint on RSG models. We calibrate the mixing length parameter by comparing model predictions with the empirical RSG temperatures in Small and Large Magellanic Clouds, Milky Way, and M31, which are inferred from the TiO band and the spectral energy distribution (SED). Although our RSG models are computed with the MESA code, our result may be applied to other stellar evolution codes, including the BEC and TWIN codes. We find evidence that the mixing length increases with increasing metallicity for both cases where the TiO and SED temperatures of RSGs are used for the calibration. Together with the recent finding of a similar correlation in low-mass red giants by Tayar et al., this implies that the metallicity dependence of the mixing length is a universal feature in post-main sequence stars of both low and high masses. Our result implies that typical Type IIP supernova (SN IIP) progenitors with initial masses of ∼ 10{--}16 {M}ȯ have a radius range of 400 {R}ȯ ≲ R≲ 800 {R}ȯ regardless of metallicity. As an auxiliary result of this study, we find that the hydrogen-rich envelope mass of SN IIP progenitors for a given initial mass is predicted to be largely independent of metallicity if the Ledoux criterion with slow semiconvection is adopted, while the Schwarzschild models predict systematically more massive hydrogen-rich envelopes for lower metallicity.

  18. Shame, recognition and love in Shakespeare’s 'King Lear'

    DEFF Research Database (Denmark)

    Montes Sanchez, Alba

    2014-01-01

    In this paper, I explore the experience of shame and its connections to recognition and love as manifested in Shakespeare’s King Lear. My main focus in this paper is the ethical relevance of shame. I start from Sartre’s account of shame in Being and Nothingness, and I consider Webber’s attempt...... to reformulate it in terms of bad faith. I reject this and propose a way to rethink shame through a study of the workings of recognition in King Lear, following Stanley Cavell’s reading of this tragedy. I claim that the experience of shame has a relational structure, which makes it a crucial part of our ethical...... sensibilities. My analysis of King Lear brings out this structure and underlines the ethical significance of shame at this structural level, by highlighting its connection to recognition and love....

  19. A red fluorescent nude mouse model of human endometriosis: advantages of a non-invasive imaging method.

    Science.gov (United States)

    Wang, Ningning; Hong, Shanshan; Tan, Jinfeng; Ke, Peiqi; Liang, Lili; Fei, Hui; Liu, Bin; Liu, Liqun; Liu, Yongdong; Yu, Bingjun

    2014-05-01

    To establish red fluorescent human endometriosis lesions in a nude mouse model and dynamically and non-invasively to compare intraperitoneal and subcutaneous injection models. Primary cultures of endometrial stromal cells (ESCs) and epithelial cells (EECs) isolated from 24 patients with a normal uterine cavity were transfected with 2.5×10(8) (Group 1) and 1.25×10(8) (Group 2) plaque-forming units (PFU) of adenovirus encoding red fluorescent protein (Ad-RFP). Transfection efficiencies, fluorescence intensity and apoptosis rate of the two types of cells were compared in vitro. A mixture of 2.5×10(8) PFU Ad-RFP-infected approximately 400 EECs cell mass and 2×10(6) ESCs for 36h was injected individually into 24 female nude mice subcutaneously (Group A) or intraperitoneally (Group B). From Day 5 after injection, an in vivo imaging system (IVIS) was used to non-invasively observe and compare the lesions of the two groups every week until Day 33. Specifically, the fluorescent intensity, positive rates, persistence time and lesion weight in the implanted human endometriosis lesions were compared. A parametric Student's t-test and two-way analysis of variance were used for statistical analysis. Compared with 1.25×10(8) PFU RFP, a titre of 2.5×10(8) PFU RFP ESCs and EECs incubated for 36h exhibited higher transfection efficiencies and higher fluorescence intensities in vitro. In vivo imaging of the fluorescent human endometriosis lesions originating from an RFP titre of 2.5×10(8) PFU showed that the intensity and lesion weight in Group A were significantly higher than in Group B. However, the two groups had the same RFP-positive rates and fluorescence persistence. The structure of each lesion was evaluated by immunohistochemistry to confirm its human endometrial origin. The red fluorescent human endometriosis model established by subcutaneously injecting 2.5×10(8) PFU RFP-transfected stromal cells and epithelial cells into nude mice had a higher fluorescent positive

  20. King James II Stuart, Irish Elites and Patriot Parliament

    Directory of Open Access Journals (Sweden)

    Stankov Kirill Nikolaevich

    2014-09-01

    Full Text Available The article is devoted to the insufficiently studied episode of the “Glorious revolution” of 1688-1689, the political fight on Green Island. On the basis of historical sources, the author shows the main directions of Irish policy of last catholic king James II, who tried to fight for his lost British throne, because the majority of population of this catholic country remained loyal to his patron. The author pays special attention to investigating the policy of different ethnic groups represented in Patriot Parliament by their elites. There were two elite groups who supported king James II and tried to influence him: “Old English” aristocracy and “Old Irish” nobility. King’s own elite group also consisted of “New English” and “New Scots”, but during the “Glorious revolution” the majority of them supported the counterpart of king James II – William Orange. Basing the study on historical sources the author proves that eventually king James II had two groups of supporters: “Old English” and “native Irish”. The article is concerned with non-investigated problem of negotiations between king James II and Irish elites and analyses the demands of the last. The author proves that acts and decisions of patriot parliament were the Irish population’s answers to the program and suggestions of king James II and that the main concessions were given to “Old English” aristocracy. The demands of “Old Irish” in agrarian issue were mainly ignored. The Patriot Parliament based the foundations of Jacobite political regime in Ireland during the restoration rebellion of 1689-1691.

  1. Modeling the Habitat of the Red-Crowned Crane (Grus japonensis Wintering in Cheorwon-Gun to Support Decision Making

    Directory of Open Access Journals (Sweden)

    Ho Gul Kim

    2016-06-01

    Full Text Available Cheorwon-gun is an important wintering area for the red-crowned crane (Grus japonensis. Although eco-tourism has been recently proposed as a means to stimulate the local economy, it may have adverse effects on the crane. We believe a science-based conservation plan is needed to mitigate these negative effects. To this end, our study had three objectives: (1 to analyze the red-crowned crane habitat and its suitability in Cheorwon-gun, using field surveys and habitat modeling; (2 to check the feasibility of alternative habitat patches across demilitarized zones (DMZs; and (3 to propose a conceptual diagram that minimizes habitat loss during development activities. We aim to quantify habitat suitability, the farmland area needed to support existing crane populations in wintertime, disturbance caused by human activities, and vehicular spatial patterns. These data could be used in spatial planning. The framework of this study and the process of making a conceptual diagram could be applied to other areas where there is a conflict between development and habitat conservation.

  2. The effect of anthocyanins from red wine and blackberry on the integrity of a keratinocyte model using ECIS.

    Science.gov (United States)

    Évora, Ana; de Freitas, Victor; Mateus, Nuno; Fernandes, Iva

    2017-11-15

    There is a growing market demand for the incorporation of plant-derived ingredients into new products for the cosmetic industry. Anthocyanins are polyphenols arising from plant secondary metabolism that have been shown to possess many bioactive properties such as free radical scavenging, antimicrobial, and chemopreventive activities. In this work, the biological activities of red wine and blackberry anthocyanins were assessed by developing a new keratinocyte barrier model using the HaCat cell line and a microelectrode-based biosensor device, referred to as Electric Cell-Substrate Impedance Sensing (ECIS). Cells were seeded at the optimal cellular density of 1.6 × 10 6 cells per mL and the half-time was calculated to be 3.55 ± 0.67 hours. The compounds' cytotoxicity was assessed and anthocyanin pigments showed no cytotoxicity towards keratinocyte cells. Wound healing assays were also performed using ECIS and it was observed that the tested pigments enhanced the healing rate of keratinocyte cells by reducing the healing time more than 50%. Cyanidin-3-glucoside presented the best results recovering 50% of the injured area in 1.48(±0.15) hours, followed by the blackberry anthocyanins (2.01 ± 0.18 hours), malvidin-3-glucoside (2.03 ± 0.09 hours) and red wine anthocyanins (2.36 ± 0.76 hours). All presented significant differences from the control 4.91(±1.11) hours.

  3. An Enhanced Spring-Particle Model for Red Blood Cell Structural Mechanics: Application to the Stomatocyte-Discocyte-Echinocyte Transformation.

    Science.gov (United States)

    Chen, Mingzhu; Boyle, Fergal J

    2017-12-01

    Red blood cells (RBCs) are the most abundant cellular element suspended in blood. Together with the usual biconcave-shaped RBCs, i.e., discocytes, unusual-shaped RBCs are also observed under physiological and experimental conditions, e.g., stomatocytes and echinocytes. Stomatocytes and echinocytes are formed from discocytes and in addition can revert back to being discocytes; this shape change is known as the stomatocyte-discocyte-echinocyte (SDE) transformation. To-date, limited research has been conducted on the numerical prediction of the full SDE transformation. Spring-particle RBC (SP-RBC) models are commonly used to numerically predict RBC mechanics and rheology. However, these models are incapable of predicting the full SDE transformation because the typically employed bending model always leads to numerical instability with severely deformed shapes. In this work, an enhanced SP-RBC model is proposed in order to extend the capability of this model type and so that the full SDE transformation can be reproduced. This is achieved through the leveraging of an advanced bending model. Transformed vesicle and RBC shapes are predicted for a range of reduced volume and reduced membrane area difference (MAD), and very good agreement is obtained in the comparison of predicted shapes with experimental observations. Through these predictions, vesicle and SDE transformation phase diagrams are developed and, importantly, in the SDE case, shape boundaries are proposed for the first time relating RBC shape categories to RBC reduced volume and reduced MAD.

  4. Scientific models red atoms, white lies and black boxes in a yellow book

    CERN Document Server

    Gerlee, Philip

    2016-01-01

    A zebrafish, the hull of a miniature ship, a mathematical equation and a food chain - what do these things have in common? They are examples of models used by scientists to isolate and study particular aspects of the world around us. This book begins by introducing the concept of a scientific model from an intuitive perspective, drawing parallels to mental models and artistic representations. It then recounts the history of modelling from the 16th century up until the present day. The iterative process of model building is described and discussed in the context of complex models with high predictive accuracy versus simpler models that provide more of a conceptual understanding. To illustrate the diversity of opinions within the scientific community, we also present the results of an interview study, in which ten scientists from different disciplines describe their views on modelling and how models feature in their work. Lastly, it includes a number of worked examples that span different modelling approaches a...

  5. Dragon-Kings, Black-Swans and Prediction (Invited)

    Science.gov (United States)

    Sornette, D.

    2010-12-01

    Extreme fluctuations or events are often associated with power law statistics. Indeed, it is a popular belief that "wild randomness'' is deeply associated with distributions with power law tails characterized by small exponents. In other words, power law tails are often seen as the epitome of extreme events (the "Black Swan'' story). Here, we document in very different systems that there is life beyond power law tails: power laws can be superseded by "dragon-kings'', monster events that occur beyond (or changing) the power law tail. Dragon-kings reveal hidden mechanisms that are only transiently active and that amplify the normal fluctuations (often described by the power laws of the normal regime). The goal of this lecture is to catalyze the interest of the community of geophysicists across all fields of geosciences so that the "invisible gorilla" fallacy may be avoided. Our own research illustrates that new statistics or representation of data are often necessary to identify dragon-kings, with strategies guided by the underlying mechanisms. Paradoxically, the monsters may be ignored or hidden by the use of inappropriate analysis or statistical tools that amount to cut a mamooth in small pieces, so as to lead to the incorrect belief that only mice exist. In order to stimulate further research, we will document and discuss the dragon-king phenomenon on the statistics of financial losses, economic geography, hydrodynamic turbulence, mechanical ruptures, avalanches in complex heterogeneous media, earthquakes, and epileptic seizures. The special status of dragon-kings open a new research program on their predictability, based on the fact that they belong to a different class of their own and express specific mechanisms amplifying the normal dynamics via positive feedbacks. We will present evidence of these claims for the predictions of material rupture, financial crashes and epileptic seizures. As a bonus, a few remarks will be offered at the end on how the dragon-king

  6. 45 King: A Story of the Southern Home

    OpenAIRE

    Deluca, Paul Matthew Webb

    2014-01-01

    The house at 45 King St. in Charleston, South Carolina is more than a home. It is a story of the home. A story told through history, through a vision exhibited in architectural drawings, and through the social heritage closest to my heart. 45 King is a story for the South; the story of its grandeur, its climate, its natural beauty, its hospitality, its comfort, and its veils. It is a story that was told yesterday and one that is still told today. Like an oral history, the telling of it may...

  7. Predicting Effects of Climate Change on Habitat Suitability of Red Spruce (Picea rubens Sarg. in the Southern Appalachian Mountains of the USA: Understanding Complex Systems Mechanisms through Modeling

    Directory of Open Access Journals (Sweden)

    Kyung Ah Koo

    2015-04-01

    Full Text Available Alpine, subalpine and boreal tree species, of low genetic diversity and adapted to low optimal temperatures, are vulnerable to the warming effects of global climate change. The accurate prediction of these species’ distributions in response to climate change is critical for effective planning and management. The goal of this research is to predict climate change effects on the distribution of red spruce (Picea rubens Sarg. in the Great Smoky Mountains National Park (GSMNP, eastern USA. Climate change is, however, conflated with other environmental factors, making its assessment a complex systems problem in which indirect effects are significant in causality. Predictions were made by linking a tree growth simulation model, red spruce growth model (ARIM.SIM, to a GIS spatial model, red spruce habitat model (ARIM.HAB. ARIM.SIM quantifies direct and indirect interactions between red spruce and its growth factors, revealing the latter to be dominant. ARIM.HAB spatially distributes the ARIM.SIM simulations under the assumption that greater growth reflects higher probabilities of presence. ARIM.HAB predicts the future habitat suitability of red spruce based on growth predictions of ARIM.SIM under climate change and three air pollution scenarios: 10% increase, no change and 10% decrease. Results show that suitable habitats shrink most when air pollution increases. Higher temperatures cause losses of most low-elevation habitats. Increased precipitation and air pollution produce acid rain, which causes loss of both low- and high-elevation habitats. The general prediction is that climate change will cause contraction of red spruce habitats at both lower and higher elevations in GSMNP, and the effects will be exacerbated by increased air pollution. These predictions provide valuable information for understanding potential impacts of global climate change on the spatiotemporal distribution of red spruce habitats in GSMNP.

  8. Robust Ultraviolet-Visible (UV-Vis) Partial Least-Squares (PLS) Models for Tannin Quantification in Red Wine.

    Science.gov (United States)

    Aleixandre-Tudo, José Luis; Nieuwoudt, Helené; Aleixandre, José Luis; Du Toit, Wessel J

    2015-02-04

    The validation of ultraviolet-visible (UV-vis) spectroscopy combined with partial least-squares (PLS) regression to quantify red wine tannins is reported. The methylcellulose precipitable (MCP) tannin assay and the bovine serum albumin (BSA) tannin assay were used as reference methods. To take the high variability of wine tannins into account when the calibration models were built, a diverse data set was collected from samples of South African red wines that consisted of 18 different cultivars, from regions spanning the wine grape-growing areas of South Africa with their various sites, climates, and soils, ranging in vintage from 2000 to 2012. A total of 240 wine samples were analyzed, and these were divided into a calibration set (n = 120) and a validation set (n = 120) to evaluate the predictive ability of the models. To test the robustness of the PLS calibration models, the predictive ability of the classifying variables cultivar, vintage year, and experimental versus commercial wines was also tested. In general, the statistics obtained when BSA was used as a reference method were slightly better than those obtained with MCP. Despite this, the MCP tannin assay should also be considered as a valid reference method for developing PLS calibrations. The best calibration statistics for the prediction of new samples were coefficient of correlation (R 2 val) = 0.89, root mean standard error of prediction (RMSEP) = 0.16, and residual predictive deviation (RPD) = 3.49 for MCP and R 2 val = 0.93, RMSEP = 0.08, and RPD = 4.07 for BSA, when only the UV region (260-310 nm) was selected, which also led to a faster analysis time. In addition, a difference in the results obtained when the predictive ability of the classifying variables vintage, cultivar, or commercial versus experimental wines was studied suggests that tannin composition is highly affected by many factors. This study also discusses the correlations in tannin values between the methylcellulose and protein

  9. Inverse dynamic modelling of jumping in the red-legged running frog,Kassina maculata.

    Science.gov (United States)

    Porro, Laura B; Collings, Amber J; Eberhard, Enrico A; Chadwick, Kyle P; Richards, Christopher T

    2017-05-15

    Although the red-legged running frog, Kassina maculata , is secondarily a walker/runner, it retains the capacity for multiple locomotor modes, including jumping at a wide range of angles (nearly 70 deg). Using simultaneous hind limb kinematics and single-foot ground reaction forces, we performed inverse dynamics analyses to calculate moment arms and torques about the hind limb joints during jumping at different angles in K. maculata. We show that forward thrust is generated primarily at the hip and ankle, while body elevation is primarily driven by the ankle. Steeper jumps are achieved by increased thrust at the hip and ankle and greater downward rotation of the distal limb segments. Because of its proximity to the GRF vector, knee posture appears to be important in controlling torque directions about this joint and, potentially, torque magnitudes at more distal joints. Other factors correlated with higher jump angles include increased body angle in the preparatory phase, faster joint openings and increased joint excursion, higher ventrally directed force, and greater acceleration and velocity. Finally, we demonstrate that jumping performance in K. maculata does not appear to be compromised by presumed adaptation to walking/running. Our results provide new insights into how frogs engage in a wide range of locomotor behaviours and the multi-functionality of anuran limbs. © 2017. Published by The Company of Biologists Ltd.

  10. Improving Regional Forecast by Assimilating Atmospheric InfraRed Sounder (AIRS) Profiles into WRF Model

    Science.gov (United States)

    Chou, Shih-Hung; Zavodsky, Brad; Jedlovec, Gary J.

    2009-01-01

    In data sparse regions, remotely-sensed observations can be used to improve analyses and produce improved forecasts. One such source comes from the Atmospheric InfraRed Sounder (AIRS), which together with the Advanced Microwave Sounding Unit (AMSU), represents one of the most advanced space-based atmospheric sounding systems. The purpose of this paper is to describe a procedure to optimally assimilate high resolution AIRS profile data into a regional configuration of the Advanced Research WRF (ARW) version 2.2 using WRF-Var. The paper focuses on development of background error covariances for the regional domain and background type, and an optimal methodology for ingesting AIRS temperature and moisture profiles as separate overland and overwater retrievals with different error characteristics. The AIRS thermodynamic profiles are derived from the version 5.0 Earth Observing System (EOS) science team retrieval algorithm and contain information about the quality of each temperature layer. The quality indicators were used to select the highest quality temperature and moisture data for each profile location and pressure level. The analyses were then used to conduct a month-long series of regional forecasts over the continental U.S. The long-term impacts of AIRS profiles on forecast were assessed against verifying NAM analyses and stage IV precipitation data.

  11. AFSC/RACE/SAP/Long: Data from: Embryo development in golden king crab, Lithodes aequispina.

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data from this study, describes embryo development in Golden king crab, Lithodes aequispinus. Six female multiparous golden king crab were captured from the...

  12. Fitting a code-red virus spread model: An account of putting theory into practice

    NARCIS (Netherlands)

    Kolesnichenko, A.V.; Haverkort, Boudewijn R.H.M.; Remke, Anne Katharina Ingrid; de Boer, Pieter-Tjerk

    This paper is about fitting a model for the spreading of a computer virus to measured data, contributing not only the fitted model, but equally important, an account of the process of getting there. Over the last years, there has been an increased interest in epidemic models to study the speed of

  13. Modelling of Ethanol Production from Red Beet Juice by Saccharomyces cerevisiae under Thermal and Acid Stress Conditions

    Directory of Open Access Journals (Sweden)

    Donaji Jiménez-Islas

    2014-01-01

    Full Text Available In this work the effects of pH and temperature on ethanol production from red beet juice by the strains Saccharomyces cerevisiae ITD00196 and S. cerevisiae ATCC 9763 are studied. Logistic, Pirt, and Luedeking-Piret equations were used to describe quantitatively the microbial growth, substrate consumption, and ethanol production, respectively. The two S. cerevisiae strains used in this study were able to produce ethanol with high yield and volumetric productivity under acid and thermal stress conditions. The equations used to model the fermentation kinetics fit very well with the experimental data, thus establishing that ethanol production was growth associated under the evaluated conditions. The yeast S. cerevisiae ITD00196 had the best fermentative capacity and could be considered as an interesting option to develop bioprocesses for ethanol production.

  14. Yeast red pigment modifies Amyloid beta growth in Alzheimer disease models in both Saccharomyces cerevisiae and Drosophila melanogaster.

    Science.gov (United States)

    Nevzglyadova, Olga V; Mikhailova, Ekaterina V; Amen, Triana R; Zenin, Valeriy V; Artemov, Alexey V; Kostyleva, Elena I; Mezhenskaya, Daria A; Rodin, Dmitry I; Saifitdinova, Alsu F; Khodorkovskii, Mikhail A; Sarantseva, Svetlana V; Soidla, Tonu R

    2015-01-01

    The effect of yeast red pigment on amyloid-β (Aβ) aggregation and fibril growth was studied in yeasts, fruit flies and in vitro. Yeast strains accumulating red pigment (red strains) contained less amyloid and had better survival rates compared to isogenic strains without red pigment accumulation (white strains). Confocal and fluorescent microscopy was used to visualise fluorescent Aβ-GFP aggregates. Yeast cells containing less red pigment had more Aβ-GFP aggregates despite the lower level of overall GFP fluorescence. Western blot analysis with anti-GFP, anti-Aβ and A11 antibodies also revealed that red cells contained a considerably lower amount of Aβ GFP aggregates as compared to white cells. Similar results were obtained with exogenous red pigment that was able to penetrate yeast cells. In vitro experiments with thioflavine and TEM showed that red pigment effectively decreased Aβ fibril growth. Transgenic flies expressing Aβ were cultivated on medium containing red and white isogenic yeast strains. Flies cultivated on red strains had a significant decrease in Aβ accumulation levels and brain neurodegeneration. They also demonstrated better memory and learning indexes and higher locomotor ability.

  15. Depositional and diagenetic models of some miocene evaporites on the Red Sea coast, Egypt

    Science.gov (United States)

    El Sayed A. A., Youssef

    1986-06-01

    The Miocene evaporites on the Red Sea coast, Egypt, are interpreted as a sabkha-chenier complex, which includes deposition in shallow water as well as in supratidal environments Costal sabkhas and shallow subaqueous evaporite sequences are recognised. The subaqueous sequence is represented by nodular mosaic and massive crystalline gypsum covered by a surface layer of nodular, white, dense powdery anhydrite. The sabkha sequences are represented by (a) small mounds overlying the older rock unit (Gebel El Rusas Formation) composed of fenestral stromatolitic and nodular dolomites overlain by a dolomitic limestone layer, (b) thin layer overlying the subaqueous evaporite sequence and composed of fenestral stromatolitic dolomite overlain by a nodular anhydrite layer. The nodular structure in the subaqueous as well as the sabkha sequences is formed diagenetically by transformation and recrystallization process. The dolomites in both sabkha sequences (a and b) are characterised by low Na + concentrations (143 to 755 ppm) and low values of δ 18O (- 1.85 to -8.7‰ PDB). This indicates that the dolomites were formed from saline water mixed with fresh water. These dolomites are also characterised by a low δ 13C (-12.95 to -27.1‰ PDB). This shows that the light carbon produced by the degradation of organic matter through the sulphate reduction process has played a significant role in the formation of these dolomites. Both microcrystalline and megacrystalline white dolomites are recognised in sabkha sequences. Relatively high concentrations of lead, zinc and copper are associated with the high percent of megacrystalline white dolomite.

  16. Red Hill

    Science.gov (United States)

    Information about the Red Hill Bulk Fuel Storage Facility in Hawaii Administrative Order on Consent (AOC), an enforceable agreement of the Hawaii Department of Health, the Environmental Protection Agency, and the U.S. Navy -- Defense Logistics Agency.

  17. Efficient ensemble forecasting of marine ecology with clustered 1D models and statistical lateral exchange: application to the Red Sea

    Science.gov (United States)

    Dreano, Denis; Tsiaras, Kostas; Triantafyllou, George; Hoteit, Ibrahim

    2017-07-01

    Forecasting the state of large marine ecosystems is important for many economic and public health applications. However, advanced three-dimensional (3D) ecosystem models, such as the European Regional Seas Ecosystem Model (ERSEM), are computationally expensive, especially when implemented within an ensemble data assimilation system requiring several parallel integrations. As an alternative to 3D ecological forecasting systems, we propose to implement a set of regional one-dimensional (1D) water-column ecological models that run at a fraction of the computational cost. The 1D model domains are determined using a Gaussian mixture model (GMM)-based clustering method and satellite chlorophyll-a (Chl-a) data. Regionally averaged Chl-a data is assimilated into the 1D models using the singular evolutive interpolated Kalman (SEIK) filter. To laterally exchange information between subregions and improve the forecasting skills, we introduce a new correction step to the assimilation scheme, in which we assimilate a statistical forecast of future Chl-a observations based on information from neighbouring regions. We apply this approach to the Red Sea and show that the assimilative 1D ecological models can forecast surface Chl-a concentration with high accuracy. The statistical assimilation step further improves the forecasting skill by as much as 50%. This general approach of clustering large marine areas and running several interacting 1D ecological models is very flexible. It allows many combinations of clustering, filtering and regression technics to be used and can be applied to build efficient forecasting systems in other large marine ecosystems.

  18. Efficient ensemble forecasting of marine ecology with clustered 1D models and statistical lateral exchange: application to the Red Sea

    KAUST Repository

    Dreano, Denis

    2017-05-24

    Forecasting the state of large marine ecosystems is important for many economic and public health applications. However, advanced three-dimensional (3D) ecosystem models, such as the European Regional Seas Ecosystem Model (ERSEM), are computationally expensive, especially when implemented within an ensemble data assimilation system requiring several parallel integrations. As an alternative to 3D ecological forecasting systems, we propose to implement a set of regional one-dimensional (1D) water-column ecological models that run at a fraction of the computational cost. The 1D model domains are determined using a Gaussian mixture model (GMM)-based clustering method and satellite chlorophyll-a (Chl-a) data. Regionally averaged Chl-a data is assimilated into the 1D models using the singular evolutive interpolated Kalman (SEIK) filter. To laterally exchange information between subregions and improve the forecasting skills, we introduce a new correction step to the assimilation scheme, in which we assimilate a statistical forecast of future Chl-a observations based on information from neighbouring regions. We apply this approach to the Red Sea and show that the assimilative 1D ecological models can forecast surface Chl-a concentration with high accuracy. The statistical assimilation step further improves the forecasting skill by as much as 50%. This general approach of clustering large marine areas and running several interacting 1D ecological models is very flexible. It allows many combinations of clustering, filtering and regression technics to be used and can be applied to build efficient forecasting systems in other large marine ecosystems.

  19. Articulating nurse practitioner practice using King's theory of goal attainment.

    Science.gov (United States)

    de Leon-Demare, Kathleen; MacDonald, Jane; Gregory, David M; Katz, Alan; Halas, Gayle

    2015-11-01

    To further understand the interactions between nurse practitioners (NPs) and patients, King's nursing theory of goal attainment was applied as the conceptual framework to describe the interactions between NPs and patients in the primary care setting. Six dyads of NPs and their patients were video- and audio-taped over three consecutive clinic visits. For the purposes of this arm of the study, the audio-taped interactions were transcribed and then coded using King's concepts in her theory of goal attainment. King's theory was applicable to describe NP practice. King's concepts and processes of nurse-patient interactions, such as disturbances, mutual goal setting, and transactions, were observed in NP-patient interactions. Disturbances during clinical encounters were essential in the progression toward goal attainment. Elements, such as social exchange, symptom reporting, role explanation, and information around clinical processes facilitated relationship building. NPs as practitioners need to be reflective of their own practice, embrace disturbances in the clinical encounter, and attend to these as opportunities for mutual goal setting. ©2015 American Association of Nurse Practitioners.

  20. Ornamental colors reveal age in the king penguin

    NARCIS (Netherlands)

    Nicolaus, Marion; Le Bohec, Celine; Nolan, Paul M.; Gauthier-Clerc, Michel; Le Maho, Yvon; Komdeur, Jan; Jouventin, Pierre

    2007-01-01

    We investigated whether delayed plumage maturation occurred in king penguins (Aptenodytes patagonicus). Therefore we examined the relationships between age and sex on spectral properties and size of two colored plumage patches and a UV-reflective beak spot, using known-age cohorts. Unlike the

  1. The labour ward analgesic service at King Edward VIII Hospital ...

    African Journals Online (AJOL)

    Abstract The provision of analgesic services to the labour ward at King Edward VIII Hospital was studied during a I-week period. Of249 patients, 113 (45%) received no analgesia whatsoever. Intramuscular pethidine was the commonest form of analgesia and was used in 97 patients (39%). Thirty-six patients (14%) received ...

  2. Littoral Encounters : The Shore as Cultural Interface in King Horn

    NARCIS (Netherlands)

    Sobecki, Sebastian

    2006-01-01

    1. III * Later Medieval: Excluding Chaucer -- Brown et al., 10.1093 ... ... between the Saracens and the londisse men allied to the protagonist (' Littoral Encounters: the Shore as Cultural Interface in King Horn', Al-Mas a ... www.ywes.oxfordjournals.org/cgi/content/full/man0092 2.Murray, Alan V.

  3. Case Report: Bullet in heart removed from knee | King | Malawi ...

    African Journals Online (AJOL)

    Case Report: Bullet in heart removed from knee. M King. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/mmj.v27i3.10 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...

  4. The King-Denborough syndrome in the paediatric patient.

    African Journals Online (AJOL)

    We describe the management of two children with a diagnosis of King Denborough syndrome. The first case is that of a 23-month-old term male infant requiring repair of a cleft palate. After flushing the anaesthetic machine, infusions of remifentanil at 0.25 µ/kg/min and propofol at 12 mg/kg/hr were commenced. These were ...

  5. Contrapuntal Significations in Wole Soyinka's Death and the King's ...

    African Journals Online (AJOL)

    Wole Soyinka's Death and the King's Horseman has been widely acclaimed as a great example of African tragedy. It is, in fact, the dramatic aggregation of Soyinka's treatise in Myth, Literature and the African World. Hence, the play is most often 'read' in the lights of its 'difference' from western notions of the tragic, the place ...

  6. Parts of Antarctica's King George Island are littered with trash

    Science.gov (United States)

    Kumar, Mohi

    2013-02-01

    A report released 7 February by ecologists from Germany's Friedrich Schiller University Jena reveals that parts of King George Island, a logistical hub for international research in Antarctica, are home to open pits of trash, decaying field huts, and other forms of pollution.

  7. Evaluation of medical consultation letters at King Fahd Hospital, Al ...

    African Journals Online (AJOL)

    Evaluation of medical consultation letters at King Fahd Hospital, Al Hufuf, Saudi Arabia. Hamed Abd Allah Al Wadaani, Magdy Hassan Balaha. Abstract. Background: In surgical wards, it is of paramount importance to communicate with other health care providers, mostly physicians, referring patients to them for their ...

  8. The Institute of Epileptology of King's College, University of London.

    Science.gov (United States)

    Reynolds, E H

    1995-01-01

    The Institute of Epileptology of King's College, London has arisen from need and from opportunity. The need is due to the relative neglect nationally and internationally of the most common serious brain disorder with important physical, psychological, and social complications. The relative neglect is reflected in services, research, charitable donations, public profile, and stigma and in a serious lack of professional education. The opportunity arose because of the existence in several medical institutions at Denmark Hill, London, of a group of medical and related colleagues with a special interest covering almost every aspect of this multidisciplinary disorder who agreed to combine their expertise in this initiative. The idea was born and developed in 1991-1992 and was supported by all the parent institutions: The Maudsley and King's College Hospitals, St. Piers Lingfield, The Institute of Psychiatry, King's College School of Medicine and Dentistry, and the School of Life, Basic Medical and Health Sciences, all under the umbrella of King's College, University of London. Further stimulus and help came from a group of dedicated supporters in private and public life. There are three strands to this initiative: (a) a charity, The Fund for Epilepsy; (b) the clinical Centre for Epilepsy, which was formally opened at the Maudsley Hospital in July 1994; and (c) the academic Institute of Epileptology for research and teaching, which was launched on November 15, 1994.

  9. Validation of the King's Health Questionnaire for South Africa in ...

    African Journals Online (AJOL)

    Objective. To validate the King's Health Questionnaire for urinary incontinence in the local South African English, Afrikaans and isiXhosa female community. Design. A cohort analytical study. Setting and subjects. The study utilised a sample of convenience. Women with urinary incontinence attending the gynaecology clinic ...

  10. Growth, chemical components and ensiling characteristics of king ...

    African Journals Online (AJOL)

    user

    2012-08-09

    Aug 9, 2012 ... moisture content reduction, while the 3rd cutting silage tended to reduce NH3-N content and its pH value was not affected ... contents of CP, crude fat, crude fiber, crude ash and WSC, the 1st cutting of king grass might have best nutrient value, while ..... Studies on yield and nutrition constitution of alfalfa in ...

  11. International education, the internet, and the Three Kings experiment

    NARCIS (Netherlands)

    Kooijman, J.; Davies, J.; Berg-Cross, L.; Copier, L.; Asby, A.

    2004-01-01

    The current project linked students in three universities in a guided discussion of the movie, Three Kings. The goals were to assess the viability of having students from three different courses, in three different universities, in three different countries find common ground to have intellectual

  12. New Light on the Legendary King Nechepsos of Egypt

    DEFF Research Database (Denmark)

    Ryholt, Kim

    2011-01-01

    This paper identifies several indigenous Egyptian attestations of King Nechepsos, previously well known from Classical sources. The name may be understood as ‘Necho the Wise’, and refers to Necho II of the Twenty-sixth Dynasty. His association with astrology may be related to an eclipse near...

  13. Anogeissus sericea var. nummalaria King ex Duthie (Combretaceae ...

    Indian Academy of Sciences (India)

    Anogeissus sericea var. nummalaria King ex Duthie (Combretaceae) is moderate sized multipurpose hard wood tree of dry deciduous forests with drooping branches and yellow to brownish-yellow flowers. it is endemic to Rajasthan and is considered to be a threatened tree of the region due to over exploitation for timber ...

  14. Illustration of a fingerprinting method to isolate Gold King ...

    Science.gov (United States)

    Detecting the Gold King Mine metals as the release plume passed was difficult once it entered the San Juan River on August 8, 2015. Plume metals concentrations were relatively low after 200 km of travel and deposition in the Animas River while background concentrations of the same metals were high due to high sediment load in the San Juan River. A metal fingerprinting technique was used to isolate metals in the Gold King release from background using the measured concentrations of the 23 TAL metals (Metal/Cynaide Target Analyte List) available with most water samples. The method associates the concentration of trace metals to that of aluminum or iron as representative of the dominant metals in the geologic substrate. Metal concentrations can be plotted together, as in Figure 1A, or the ratio can be computed for each sample for use as a value, such as plotted in time in Figure 1B. The correlation technique allowed maximum use of typically available water sample data to isolate Gold King metals as contaminants within the varying background concentrations associated with the natural sediments of the San Juan River. To be presented at the New Mexico Water Institute Symposium, 2nd Annual Conference on Environmental Conditionsof the Animas and San Juan Watersheds with Emphasis on Gold King Mine and Other Mine Waste Issues.

  15. Allelopathic Effects of Chromolaena Odorata L. (R. M. King and ...

    African Journals Online (AJOL)

    Allelopathic effects of Chromolaena odorata L. (R. M. KING AND ROBINSON) aqueous leaf extract and residues incorporated in the soil on the growth and water status of Lycopersicon esculentum Mill were studied. Significant growth reductions in Lycopersicon esculentum were observed from additions of C. odorata ...

  16. New Light on the Legendary King Nechepsos of Egypt

    DEFF Research Database (Denmark)

    Ryholt, Kim

    2011-01-01

    This paper identifies several indigenous Egyptian attestations of King Nechepsos, previously well known from Classical sources. The name may be understood as ‘Necho the Wise’, and refers to Necho II of the Twenty-sixth Dynasty. His association with astrology may be related to an eclipse near the ...

  17. The King-Denborough syndrome in the paediatric patient. | Maharaj ...

    African Journals Online (AJOL)

    We describe the management of two children with a diagnosis of King Denborough syndrome. The first case is that of a 23-month-old term male infant requiring repair of a cleft palate. After flushing the anaesthetic machine, infusions of remifentanil at 0.25 μ/kg/min and propofol at 12 mg/kg/hr were commenced. These were ...

  18. Mutual mate choice for olorful traits in King Penguins

    NARCIS (Netherlands)

    Nolan, Paul M.; Dobson, F. Stephen; Nicolaus, Marion; Karels, Tim J.; McGraw, Kevin J.; Jouventin, Pierre

    While studies of mate choice based on male color pattern are ubiquitous, studies of mate choice based on ornamental color traits in sexually monomorphic species are less common. We conducted manipulative field experiments on two color ornaments of king penguins (Aptenodytes patagonicus), the size of

  19. Adoption of open source software in business models: a Red Hat and IBM case study

    CSIR Research Space (South Africa)

    Munga, N

    2009-10-01

    Full Text Available beyond those of customer demand. Linux provided it with a common set of APIs across its entire product line, providing a unified architecture for software developers. IBM refocused on targeting its traditional large corporate customers, and the need... and its position in the market identified [15]. Various types of business models are discussed in the literature. Rappa [16], using the customer relationship as the primary dimension, defines the brokerage model, information intermediary model...

  20. The generalized STAR(1,1) modeling with time correlated errors to red-chili weekly prices of some traditional markets in Bandung, West Java

    Science.gov (United States)

    Nisa Fadlilah F., I.; Mukhaiyar, Utriweni; Fahmi, Fauzia

    2015-12-01

    The observations at a certain location may be linearly influenced by the previous times of observations at that location and neighbor locations, which could be analyzed by Generalized STAR(1,1). In this paper, the weekly red-chili prices secondary-data of five main traditional markets in Bandung are used as case study. The purpose of GSTAR(1,1) model is to forecast the next time red-chili prices at those markets. The model is identified by sample space-time ACF and space-time PACF, and model parameters are estimated by least square estimation method. Theoretically, the errors' independency assumption could simplify the parameter estimation's problem. However, practically that assumption is hard to satisfy since the errors may be correlated each other's. In red-chili prices modeling, it is considered that the process has time-correlated errors, i.e. martingale difference process, instead of follow normal distribution. Here, we do some simulations to investigate the behavior of errors' assumptions. Although some of results show that the behavior of the errors' model are not always followed the martingale difference process, it does not corrupt the goodness of GSTAR(1,1) model to forecast the red-chili prices at those five markets.

  1. 78 FR 39599 - Safety Zone; Independence Day Fireworks, Kings Beach, CA

    Science.gov (United States)

    2013-07-02

    ... SECURITY Coast Guard 33 CFR Part 165 Safety Zone; Independence Day Fireworks, Kings Beach, CA AGENCY: Coast... safety zone for the Independence Day Fireworks, Kings Beach, CA in the Captain of the Port, San Francisco... Marina to the launch site off of Kings Beach, CA in approximate position 39 13'55'' N, 120 01'42'' W (NAD...

  2. 77 FR 38005 - Safety Zone; Independence Day Fireworks, Kings Beach, CA

    Science.gov (United States)

    2012-06-26

    ... SECURITY Coast Guard 33 CFR Part 165 Safety Zone; Independence Day Fireworks, Kings Beach, CA AGENCY: Coast... safety zone for the Kings Beach Independence Day Fireworks display from 7 a.m. until 10 p.m. on July 3... from Tahoe Keys Marina to the launch site off of Kings Beach, CA at position 39 13'55'' N, 120 01'42...

  3. Ugiuvangmiut Quliapyuit = King Island Tales. Eskimo History and Legends from Bering Strait.

    Science.gov (United States)

    Kaplan, Lawrence D., Ed.

    The collection of native tales from King Island, Alaska, contains tales told originally in Inupiaq Eskimo by seven native elders. Introductory sections provide background information on the storytellers, King Island Village and its people, traditional life there, and the language of the King Islanders. The 25 tales are divided into groups:…

  4. Insights from ecological niche modeling on the taxonomic distinction and niche differentiation between the black-spotted and red-spotted tokay geckoes (Gekko gecko).

    Science.gov (United States)

    Zhang, Yueyun; Chen, Chongtao; Li, Li; Zhao, Chengjian; Chen, Weicai; Huang, Yong

    2014-09-01

    The black-spotted tokay and the red-spotted tokay are morphologically distinct and have largely allopatric distributions. The black-spotted tokay is characterized by a small body size and dark skin with sundry spots, while the red-spotted tokay has a relatively large body size and red spots. Based on morphological, karyotypic, genetic, and distribution differences, recent studies suggested their species status; however, their classifications remain controversial, and additional data such as ecological niches are necessary to establish firm hypotheses regarding their taxonomic status. We reconstructed their ecological niches models using climatic and geographic data. We then performed niche similarity tests (niche identity and background tests) and point-based analyses to explore whether ecological differentiation has occurred, and whether such differences are sufficient to explain the maintenance of their separate segments of environmental ranges. We found that both niche models of the black- and the red-spotted tokay had a good fit and a robust performance, as indicated by the high area under the curve (AUC) values ("black" = 0.982, SD = ± 0.002, "red" = 0.966 ± 0.02). Significant ecological differentiation across the entire geographic range was found, indicating that the involvement of ecological differentiation is important for species differentiation. Divergence along the environmental axes is highly associated with climatic conditions, with isothermality being important for the "black" form, while temperature seasonality, precipitation of warmest quarter, and annual temperature range together being important for the "red" form. These factors are likely important factors in niche differentiation between the two forms, which result in morphological replacement. Overall, beside morphological and genetic differentiation information, our results contribute to additional insights into taxonomic distinction and niche differentiation between the black- and the red

  5. Environmental Modeling Using Remote Sensing And GIS For Sustainable Ecotourism Development Of RAS Banas Area, Red Sea Coast, Egypt

    International Nuclear Information System (INIS)

    Nasr, A.H.; El-Leithy, B.M.; Khalaf, F.I.

    2003-01-01

    This study aims at supporting sound planning for sustainable ecotourism development of Ras Banas area along the Red Sea Coast, Egypt. This area is characterized by unique coastal ecosystems and fragile environment. Landsat Thematic Mapper (TM) data have been used as a source of information for the preparation of different thematic geo-environmental maps of the coastal area through visual or digital image interpretation. A digital database for the area was established and the essential derived maps representing data layers on the spatial distribution of different types of terrestrial ecosystems have been used for building a Geographic Information System (GIS) model. The thematic maps include: (1) land cover classification with emphasis on the coastal formations (sabkha, coral reefs, coastal islands and mangroves), (2) shore line, (3) drainage network and (4) basins and flash flood hazard map. In addition, topographic sheets at scale of I :50,000 were digitized and transformed to GIS digital maps that include two layers for coordinate grid and contour lines with spot heights. A spatial model has been developed and constructed for analyzing large spatial data in a GIS environment. The development of the model scenarios aimed at quantifying the impacts of different derived layers that required an assessment of different factors influencing the model. Different layers have been given different weights, based on their anticipated contributions to the model. The model was subjected to various dynamic trials related to its layer components and weights. An environmental sensitivity index map was prepared, where the coastal zone was classified, on the basis of its relative sensitivity to anthropogenic activities, into a high, a medium and a low sensitivity classes. Sensitivity classification has been used for the delineation of the suitable sites for potential sustainable ecotourism development. This derivative mapping and integrated modeling has added a significant new

  6. Nutrient delivery to Lake Winnipeg from the Red-Assiniboine River Basin – A binational application of the SPARROW model

    Science.gov (United States)

    Benoy, Glenn A; Jenkinson, R. Wayne; Robertson, Dale M.; Saad, David A.

    2016-01-01

    Excessive phosphorus (TP) and nitrogen (TN) inputs from the Red–Assiniboine River Basin (RARB) have been linked to eutrophication of Lake Winnipeg; therefore, it is important for the management of water resources to understand where and from what sources these nutrients originate. The RARB straddles the Canada–United States border and includes portions of two provinces and three states. This study represents the first binationally focused application of SPAtially Referenced Regressions on Watershed attributes (SPARROW) models to estimate loads and sources of TP and TN by jurisdiction and basin at multiple spatial scales. Major hurdles overcome to develop these models included: (1) harmonization of geospatial data sets, particularly construction of a contiguous stream network; and (2) use of novel calibration steps to accommodate limitations in spatial variability across the model extent and in the number of calibration sites. Using nutrient inputs for a 2002 base year, a RARB TP SPARROW model was calibrated that included inputs from agriculture, forests and wetlands, wastewater treatment plants (WWTPs) and stream channels, and a TN model was calibrated that included inputs from agriculture, WWTPs and atmospheric deposition. At the RARB outlet, downstream from Winnipeg, Manitoba, the majority of the delivered TP and TN came from the Red River Basin (90%), followed by the Upper Assiniboine River and Souris River basins. Agriculture was the single most important TP and TN source for each major basin, province and state. In general, stream channels (historically deposited nutrients and from bank erosion) were the second most important source of TP. Performance metrics for the RARB SPARROW model are similarly robust compared to other, larger US SPARROW models making it a potentially useful tool to address questions of where nutrients originate and their relative contributions to loads delivered to Lake Winnipeg.

  7. Qualification of the Lasentec M600P Particle Size Analyzer and the Red Valve Model 1151 Pressure Sensor

    Energy Technology Data Exchange (ETDEWEB)

    JR Bontha; NG Colton; EA Daymo; TD Hylton; CK Bayne; TH May

    2000-01-28

    status of a slurry transfer could be inferred from the pressure-drop measurement. In 1998, four Red Valve pressure sensors (with Sensotech Model AE-213 pressure transducers) were installed before and after the booster pumps of the 4-in. slurry (SL-200) and supernatant (SN-200) transfer lines between Tank 241-C-106 and Tank 241-AY-1 02. These pressure sensors have been in operation for over 1 year, and to date, the sensors have been trouble-flee according to the operators involved with slurry and supernatant transfer operations. Based on these observations, it is apparent that the Red Valve pressure sensors could be installed at the end of the slurry transfer lines and used to measure the pressure drop in the system.

  8. Dietary red palm oil supplementation reduces myocardial infarct size in an isolated perfused rat heart model

    Directory of Open Access Journals (Sweden)

    Esterhuyse Adriaan J

    2010-06-01

    Full Text Available Abstract Background and Aims Recent studies have shown that dietary red palm oil (RPO supplementation improves functional recovery following ischaemia/reperfusion in isolated hearts. The main aim of this study was to investigate the effects of dietary RPO supplementation on myocardial infarct size after ischaemia/reperfusion injury. The effects of dietary RPO supplementation on matrix metalloproteinase-2 (MMP2 activation and PKB/Akt phosphorylation were also investigated. Materials and methods Male Wistar rats were divided into three groups and fed a standard rat chow diet (SRC, a SRC supplemented with RPO, or a SRC supplemented with sunflower oil (SFO, for a five week period, respectively. After the feeding period, hearts were excised and perfused on a Langendorff perfusion apparatus. Hearts were subjected to thirty minutes of normothermic global ischaemia and two hours of reperfusion. Infarct size was determined by triphenyltetrazolium chloride staining. Coronary effluent was collected for the first ten minutes of reperfusion in order to measure MMP2 activity by gelatin zymography. Results Dietary RPO-supplementation decreased myocardial infarct size significantly when compared to the SRC-group and the SFO-supplemented group (9.1 ± 1.0% versus 30.2 ± 3.9% and 27.1 ± 2.4% respectively. Both dietary RPO- and SFO-supplementation were able to decrease MMP2 activity when compared to the SRC fed group. PKB/Akt phosphorylation (Thr 308 was found to be significantly higher in the dietary RPO supplemented group when compared to the SFO supplemented group at 10 minutes into reperfusion. There was, however, no significant changes observed in ERK phosphorylation. Conclusions Dietary RPO-supplementation was found to be more effective than SFO-supplementation in reducing myocardial infarct size after ischaemia/reperfusion injury. Both dietary RPO and SFO were able to reduce MMP2 activity, which suggests that MMP2 activity does not play a major role in

  9. Fat King Penguins Are Less Steady on Their Feet.

    Science.gov (United States)

    Willener, Astrid S T; Handrich, Yves; Halsey, Lewis G; Strike, Siobhán

    2016-01-01

    Returning to the shore after a feeding sojourn at sea, king penguins often undertake a relatively long terrestrial journey to the breeding colony carrying a heavy, mostly frontal, accumulation of fat along with food in the stomach for chick-provisioning. There they must survive a fasting period of up to a month in duration, during which their complete reliance on endogenous energy stores results in a dramatic loss in body mass. Our aim was to determine if the king penguin's walking gait changes with variations in body mass. We investigated this by walking king penguins on a treadmill while instrumented with an acceleration data logger. The stride frequency, dynamic body acceleration (DBA) and posture of fat (pre-fasting; 13.2 kg) and slim (post fasting; 11 kg) king penguins were assessed while they walked at the same speed (1.4 km/h) on a treadmill. Paired statistical tests indicated no evidence for a difference in dynamic body acceleration or stride frequency between the two body masses however there was substantially less variability in both leaning angle and the leaning amplitude of the body when the birds were slimmer. Furthermore, there was some evidence that the slimmer birds exhibited a decrease in waddling amplitude. We suggest the increase in variability of both leaning angle and amplitude, as well as a possibly greater variability in the waddling amplitude, is likely to result from the frontal fat accumulation when the birds are heavier, which may move the centre of mass anteriorly, resulting in a less stable upright posture. This study is the first to use accelerometry to better understand the gait of a species within a specific ecological context: the considerable body mass change exhibited by king penguins.

  10. Dynamic Strength and Accumulated Plastic Strain Development Laws and Models of the Remolded Red Clay under Long-Term Cyclic Loads: Laboratory Test Results

    Directory of Open Access Journals (Sweden)

    Li Jian

    2015-09-01

    Full Text Available The dynamic strength and accumulated plastic strain are two important parameters for evaluating the dynamic response of soil. As a special clay, the remolded red clay is often used as the high speed railway subgrade filling, but studies on its dynamic characteristics are few. For a thorough analysis of the suitability of the remolded red clay as the subgrade filling, a series of long-term cyclic load triaxial test under different load histories are carried out. Considering the influence of compactness, confining pressure, consolidation ratio, vibration frequency and dynamic load to the remolded red clay dynamic property, the tests obtain the development curves of the dynamic strength and accumulated plastic strain under different test conditions. Then, through curve fitting method, two different hyperbolic models respectively for the dynamic strength and accumulated plastic strain are built, which can match the test datum well. By applying the dynamic strength model, the critical dynamic strength of the remolded red clay are gained. Meanwhile, for providing basic datum and reference for relevant projects, all key parameters for the dynamic strength and accumulated plastic strain of the remolded red clay are given in the paper.

  11. Arsenic in groundwater of the Red River floodplain, Vietnam: Controlling geochemical processes and reactive transport modeling

    DEFF Research Database (Denmark)

    Postma, Diederik Jan; Larsen, Flemming; Hue, N.T.M.

    2007-01-01

    chemistry over depth is homogeneous and a reactive transport model was constructed to quantify the geochemical processes along the vertical groundwater flow component. A redox zonation model was constructed using the partial equilibrium approach with organic carbon degradation in the sediment as the only...... rate controlling parameter. Apart from the upper meter a constant degradation rate of 0.15 C mmol/L/yr could explain the redox zonation throughout the aquifer. Modeling also indicates that the Fe-oxide being reduced is of a stable type like goethite or hematite. Arsenic is contained in the Fe...

  12. Evaluation of Stem Cell-Derived Red Blood Cells as a Transfusion Product Using a Novel Animal Model.

    Science.gov (United States)

    Shah, Sandeep N; Gelderman, Monique P; Lewis, Emily M A; Farrel, John; Wood, Francine; Strader, Michael Brad; Alayash, Abdu I; Vostal, Jaroslav G

    2016-01-01

    Reliance on volunteer blood donors can lead to transfusion product shortages, and current liquid storage of red blood cells (RBCs) is associated with biochemical changes over time, known as 'the storage lesion'. Thus, there is a need for alternative sources of transfusable RBCs to supplement conventional blood donations. Extracorporeal production of stem cell-derived RBCs (stemRBCs) is a potential and yet untapped source of fresh, transfusable RBCs. A number of groups have attempted RBC differentiation from CD34+ cells. However, it is still unclear whether these stemRBCs could eventually be effective substitutes for traditional RBCs due to potential differences in oxygen carrying capacity, viability, deformability, and other critical parameters. We have generated ex vivo stemRBCs from primary human cord blood CD34+ cells and compared them to donor-derived RBCs based on a number of in vitro parameters. In vivo, we assessed stemRBC circulation kinetics in an animal model of transfusion and oxygen delivery in a mouse model of exercise performance. Our novel, chronically anemic, SCID mouse model can evaluate the potential of stemRBCs to deliver oxygen to tissues (muscle) under resting and exercise-induced hypoxic conditions. Based on our data, stem cell-derived RBCs have a similar biochemical profile compared to donor-derived RBCs. While certain key differences remain between donor-derived RBCs and stemRBCs, the ability of stemRBCs to deliver oxygen in a living organism provides support for further development as a transfusion product.

  13. Inferring spatial memory and spatiotemporal scaling from GPS data: comparing red deer Cervus elaphus movements with simulation models.

    Science.gov (United States)

    Gautestad, Arild O; Loe, Leif E; Mysterud, Atle

    2013-05-01

    1. Increased inference regarding underlying behavioural mechanisms of animal movement can be achieved by comparing GPS data with statistical mechanical movement models such as random walk and Lévy walk with known underlying behaviour and statistical properties. 2. GPS data are typically collected with ≥ 1 h intervals not exactly tracking every mechanistic step along the movement path, so a statistical mechanical model approach rather than a mechanistic approach is appropriate. However, comparisons require a coherent framework involving both scaling and memory aspects of the underlying process. Thus, simulation models have recently been extended to include memory-guided returns to previously visited patches, that is, site fidelity. 3. We define four main classes of movement, differing in incorporation of memory and scaling (based on respective intervals of the statistical fractal dimension D and presence/absence of site fidelity). Using three statistical protocols to estimate D and site fidelity, we compare these main movement classes with patterns observed in GPS data from 52 females of red deer (Cervus elaphus). 4. The results show best compliance with a scale-free and memory-enhanced kind of space use; that is, a power law distribution of step lengths, a fractal distribution of the spatial scatter of fixes and site fidelity. 5. Our study thus demonstrates how inference regarding memory effects and a hierarchical pattern of space use can be derived from analysis of GPS data. © 2013 The Authors. Journal of Animal Ecology © 2013 British Ecological Society.

  14. A review of Red Queen models for the persistence of obligate sexual reproduction.

    Science.gov (United States)

    Lively, Curtis M

    2010-01-01

    I present a historical review of coevolutionary models for the evolutionary persistence of sexual reproduction. The focus is on the fate of obligately sexual populations facing competition with one or more obligately asexual clones. An early simulation model by Hamilton (Hamilton WD. 1980. Sex versus non-sex versus parasite. Oikos. 35:282-290.) suggested that parasites could be an important force in selecting against asexual clones, leading to the persistence of sex. This result was consistent with a number of independent verbal models generated from 1975-1983. Conversely, the models by May and Anderson (May RM, Anderson RM. 1983. Epidemiology and genetics in the coevolution of parasites and hosts. Proc R Soc Lond B Biol Sci. 219:281-313.), which included more epidemiological detail, suggested that parasites were an unlikely source of selection to favor sexual over asexual reproduction. Thus began an oscillation of opinion regarding the role of parasites in selection for sex. It would seem at present that some of the differences of opinion over time stemmed from the different ways that models were constructed, including whether the sexual population was in competition with a genetically diverse asexual population or a single clonal genotype. On theoretical grounds, parasite-mediated selection for sex seems more likely if the sexual population has options in genotypic space that are not available to the clones. Models that incorporate more ecological realism also seem more favorable to the parasite theory of sex.

  15. Assessment of Poisson, logit, and linear models for genetic analysis of clinical mastitis in Norwegian Red cows.

    Science.gov (United States)

    Vazquez, A I; Gianola, D; Bates, D; Weigel, K A; Heringstad, B

    2009-02-01

    Clinical mastitis is typically coded as presence/absence during some period of exposure, and records are analyzed with linear or binary data models. Because presence includes cows with multiple episodes, there is loss of information when a count is treated as a binary response. The Poisson model is designed for counting random variables, and although it is used extensively in epidemiology of mastitis, it has rarely been used for studying the genetics of mastitis. Many models have been proposed for genetic analysis of mastitis, but they have not been formally compared. The main goal of this study was to compare linear (Gaussian), Bernoulli (with logit link), and Poisson models for the purpose of genetic evaluation of sires for mastitis in dairy cattle. The response variables were clinical mastitis (CM; 0, 1) and number of CM cases (NCM; 0, 1, 2, ..). Data consisted of records on 36,178 first-lactation daughters of 245 Norwegian Red sires distributed over 5,286 herds. Predictive ability of models was assessed via a 3-fold cross-validation using mean squared error of prediction (MSEP) as the end-point. Between-sire variance estimates for NCM were 0.065 in Poisson and 0.007 in the linear model. For CM the between-sire variance was 0.093 in logit and 0.003 in the linear model. The ratio between herd and sire variances for the models with NCM response was 4.6 and 3.5 for Poisson and linear, respectively, and for model for CM was 3.7 in both logit and linear models. The MSEP for all cows was similar. However, within healthy animals, MSEP was 0.085 (Poisson), 0.090 (linear for NCM), 0.053 (logit), and 0.056 (linear for CM). For mastitic animals the MSEP values were 1.206 (Poisson), 1.185 (linear for NCM response), 1.333 (logit), and 1.319 (linear for CM response). The models for count variables had a better performance when predicting diseased animals and also had a similar performance between them. Logit and linear models for CM had better predictive ability for healthy

  16. Were king Stefan the First-Crowned and his son Radoslav co-rulers?

    Directory of Open Access Journals (Sweden)

    Bubalo Đorđe

    2009-01-01

    Full Text Available The Serbian historiography considers the issue of the co-ruling of King Stefan the First-Crowned and his son Radoslav as the one finally resolved. The suggested solution on the co-rule of Stefan and Radoslav may be most succinctly expressed as following: as early as in the year of 1220, due to the frail health of Stefan the First-Crowned and Radoslav's marriage to Anne the Epirus princess, Radoslav was crowned to be the king and positioned to co-rule with his father after the Byzantine model of governing. Nevertheless this point of view has some loose ends. The notion of co-ruling and the very term of 'co-ruler' are quite freely used in the scholarly works. A general consensus on the precise meaning has not been reached yet. At the point where one author perceives a co-rule, the other categorically denies it. Basically the approach equalizing the heir to the throne and the co-ruler is wrong. Although the co-rulers in most cases were the throne heirs, they cannot be called the co-rulers because of the right to inherit the throne, but for the ruling attributes that formally established that right. The conviction of the co-rule of King Stefan and his son Radoslav is founded on the interpretation of the facts coming from the following sources: entitling charters for the monastery of Žiča, produced by Stefan and Radoslav around 1220; some segments from St. Sava's biographies by Domentian and Theodosius describing the circumstances of Stefan's death-bed leaving the throne to Radoslav; the three acts of the town of Kotor from 1221 and 1227 dated by the rule of king Radoslav, the portraits of Stefan and Radoslav next to the entrance to the Church of the Ascension in the monastery of Žiča and in the nartex of the Mileševa monastery church. In the first Žiča charter, Stefan calls Radoslav his heir, while in the second Žiča charter Stefan points out Radoslav as his first-born son blessed by him to be the king of the whole state. (jegože i

  17. Generation and characterization of transgenic mice expressing mitochondrial targeted red fluorescent protein selectively in neurons: modeling mitochondriopathy in excitotoxicity and amyotrophic lateral sclerosis

    Directory of Open Access Journals (Sweden)

    Wang Yi

    2011-11-01

    Full Text Available Abstract Background Mitochondria have roles or appear to have roles in the pathogenesis of several chronic age-related and acute neurological disorders, including Charcot-Marie-Tooth disease, amyotrophic lateral sclerosis, Parkinson's disease, and cerebral ischemia, and could be critical targets for development of rational mechanism-based, disease-modifying therapeutics for treating these disorders effectively. A deeper understanding of neural tissue mitochondria pathobiologies as definitive mediators of neural injury, disease, and cell death merits further study, and the development of additional tools to study neural mitochondria will help achieve this unmet need. Results We created transgenic mice that express the coral (Discosoma sp. red fluorescent protein DsRed2 specifically in mitochondria of neurons using a construct engineered with a Thy1 promoter, specific for neuron expression, to drive expression of a fusion protein of DsRed2 with a mitochondrial targeting sequence. The biochemical and histological characterization of these mice shows the expression of mitochondrial-targeted DsRed2 to be specific for mitochondria and concentrated in distinct CNS regions, including cerebral cortex, hippocampus, thalamus, brainstem, and spinal cord. Red fluorescent mitochondria were visualized in cerebral cortical and hippocampal pyramidal neurons, ventrobasal thalamic neurons, subthalamic neurons, and spinal motor neurons. For the purpose of proof of principle application, these mice were used in excitotoxicity paradigms and double transgenic mice were generated by crossing Thy1-mitoDsRed2 mice with transgenic mice expressing enhanced-GFP (eGFP under the control of the Hlxb9 promoter that drives eGFP expression specifically in motor neurons and by crossing Thy1-mitoDsRed2 mice to amyotrophic lateral sclerosis (ALS mice expressing human mutant superoxide dismutase-1. Conclusions These novel transgenic mice will be a useful tool for better understanding

  18. Log-grade volume distribution prediction models for tree species in red oak-sweetgum stands on US mid-south minor stream bottoms

    Science.gov (United States)

    George M. Banzhaf; Thomas G. Matney; Emily B. Schultz; James S. Meadows; J. Paul Jeffreys; William C. Booth; Gan Li; Andrew W. Ezell; Theodor D. Leininger

    2016-01-01

    Red oak (Quercus section Labatae)-sweetgum (Liquidambar styraciflua L.) stands growing on mid-south bottomland sites in the United States are well known for producing high-quality grade hardwood logs, but models for estimating the quantity and quality of standing grade wood in these stands have been unavailable. Prediction...

  19. Stand-level growth and yield component models for red oak-sweetgum forests on Mid-South minor stream bottoms

    Science.gov (United States)

    Emily B. Schultz; J. Clint Iles; Thomas G. Matney; Andrew W. Ezell; James S. Meadows; Theodor D. Leininger; al. et.

    2010-01-01

    Greater emphasis is being placed on Southern bottomland hardwood management, but relatively few growth and yield prediction systems exist that are based on sufficient measurements. We present the aggregate stand-level expected yield and structural component equations for a red oak (Quercus section Lobatae)-sweetgum (Liquidambar styraciflua L.) growth and yield model....

  20. Planning a red squirrel conservation area: using a spatially explicit population dynamics model to predict the impact of felling and forest design plans

    NARCIS (Netherlands)

    Lurz, P.W.W.; Geddes, N.; Lloyd, A.J.; Shirley, M.D.E.; Rushton, B.; Burlton, B.

    2003-01-01

    This paper describes the use of a spatially explicit population model (SEPM) to investigate the effects of different forest management strategies on a red squirrel conservation area. The study was based in woodland managed by Forest Enterprise, which manages 75 000 ha of woodlands in Northumberland,

  1. Modelling and Optimization of Corrosion Inhibition of Mild Steel in Phosphoric Acid by Red Pomegranate Peels Aqueous Extract

    Directory of Open Access Journals (Sweden)

    Khalid Hamid Rashid

    2011-11-01

    Full Text Available Taguchi experimental design (TED is applied to find the optimum effectiveness of aqueous Red Pomegranate Peel (RPP extract as a green inhibitor for the corrosion of mild steel in 2M H3PO4 solution. The Taguchi methodology has been used to study the effects of changing, temperature, RPP concentration and contact period, at three levels. Weight-loss measurements were designed by construction a L9 orthogonal arrangement of experiments. Results of the efficiencies of inhibition were embraced for the signal to noise proportion & investigation of variance (ANOVA. The results were further processed with a MINITAB-17 software package to find the optimal conditions for inhibitor usage. Second order polynomial model was used for experimental data fitting. Optimum conditions for achieving the maximum corrosion inhibition efficiency are obtained from optimizing the above model and are found as follow: 39.66 °C temperature of acidic media, 38.29 ml/L inhibitor concentration and 2.95 h contact period. Results demonstrated that rate of corrosion was increased with temperature increasing & decreasing inhibitor concentration. It was concluded that the Taguchi design was adequately useful in the optimization of operating parameters and that RPP sufficiently inhibited the corrosion of steel at the range of variables studied.

  2. Patient-specific modeling and analysis of dynamic behavior of individual sickle red blood cells under hypoxic conditions

    Science.gov (United States)

    Li, Xuejin; Du, E.; Li, Zhen; Tang, Yu-Hang; Lu, Lu; Dao, Ming; Karniadakis, George

    2015-11-01

    Sickle cell anemia is an inherited blood disorder exhibiting heterogeneous morphology and abnormal dynamics under hypoxic conditions. We developed a time-dependent cell model that is able to simulate the dynamic processes of repeated sickling and unsickling of red blood cells (RBCs) under physiological conditions. By using the kinetic cell model with parameters derived from patient-specific data, we present a mesoscopic computational study of the dynamic behavior of individual sickle RBCs flowing in a microfluidic channel with multiple microgates. We investigate how individual sickle RBCs behave differently from healthy ones in channel flow, and analyze the alteration of cellular behavior and response to single-cell capillary obstruction induced by cell rheologic rigidification and morphological change due to cell sickling under hypoxic conditions. We also simulate the flow dynamics of sickle RBCs treated with hydroxyurea (HU) and quantify the relative enhancement of hemodynamic performance of HU. This work was supported by the National Institutes of Health (NIH) Grant U01HL114476.

  3. Photocatalytic removal of C.I. Basic Red 46 on immobilized TiO2 nanoparticles: artificial neural network modelling.

    Science.gov (United States)

    Khataee, A R

    2009-10-01

    C.I. Basic Red 46, commonly used as a textile dye, was photocatalytically removed using supported TiO2 nanoparticles irradiated by a 30 W UV-C lamp in a batch reactor. The investigated photocatalyst was industrial Degussa P25 (crystallite mean size 21 nm) immobilized on glass beads by a heat attachment method. The catalyst was characterized by XRD, SEM, TEM and BET techniques. The process of the dye decolorization in the presence of TiO2 nanoparticles was experimentally studied through changing the initial dye concentration, UV light intensity and initial pH. The influence of inorganic anions such as chloride, sulphate, bicarbonate, carbonate and phosphate on the photocatalytic decolorization of BR46 was investigated. The decolorization of BR46 follows the pseudo-first-order kinetic according to the Langmuir-Hinshelwood model (k1 = 0.273 mg L(-1) min(-1), 2 = 0.313 (mg L(-1))(-1)). The efficiency parameters such as apparent quantum yield and electrical energy per order (EEO) were estimated. An artificial neural network model (ANN) was developed to predict the photocatalytic decolorization of BR46 solution. The findings indicated that the ANN provided reasonable predictive performance (R2 = 0.96). The influence of each parameter on the variable studied was assessed: initial concentration of the dye being the most significant factor, followed by the initial pH and reaction time.

  4. 76 FR 22081 - North Pacific Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-04-20

    ... Crab, Aleutian Island Golden King Crab, Tanner crab rebuilding alternatives, NPFMC model workshop..., Draft assessment reviews of Snow crab, Tanner crab, BBRKC, Pribilof Island Red King Crab, Pribilof...

  5. Linear-nonlinear models of the red-green chromatic pathway.

    Science.gov (United States)

    Stockman, Andrew; Henning, G Bruce; Rider, Andrew T

    2017-11-01

    The mean hue of flickering waveforms comprising only the first two harmonics depends on their temporal alignment. We evaluate explanatory models of this hue-shift effect using previous data obtained using L- and M-cone-isolating stimuli together with chromatic sensitivity and hue discrimination data. The key questions concerned what type of nonlinearity produced the hue shifts, and where the nonlinearities lay with respect to the early band-pass and late low-pass temporal filters in the chromatic pathways. We developed two plausible models: (a) a slew-rate limited nonlinearity that follows both early and late filters, and (b) a half-wave rectifying nonlinearity-consistent with the splitting of the visual input into ON- and OFF-channels-that lies between the early and late filters followed by a compressive nonlinearity that lies after the late filter.

  6. AHP 47: THE GREEDY KING AND TRICKY MAN

    Directory of Open Access Journals (Sweden)

    Lcags so lhun 'grub ལྕགས་སོ་ལྷུན་འགྲུབ། (Klu sgrub ཀླུ་སྒྲུབ།

    2017-04-01

    Full Text Available Rgya mo skyid (b. 1992 of Mdo ba Town, Reb gong (Thun rin, Tongren County, Rma lho (Huangnan Tibetan Autonomous Prefecture, Mtsho sngon (Qinghai Province, China told me this story in an apartment in Xi'an City, Shaanxi Province on 21 August, 2016. She said, "When I was about five years old, my grandfather (Kun bzang, b. 1939 told me many stories such as this before we went to bed every night. I forgot many stories, but this story is still very clear." There was once a greedy local king who collected taxes monthly. There was also a very poor man known as Tricky Tsag thul. The local king came to Tricky's home to punish him for not paying his taxes for several months. ...

  7. Lidar-revised geologic map of the Poverty Bay 7.5' quadrangle, King and Pierce Counties, Washington

    Science.gov (United States)

    Tabor, Rowland W.; Booth, Derek B.; Troost, Kathy Goetz

    2014-01-01

    For this map, we interpreted a 6-ft-resolution lidar digital elevation model combined with the geology depicted on the Geologic Map of the Poverty Bay 7.5' Quadrangle, King and Pierce Counties, Washington (Booth and others, 2004b). The authors of the 2004 map described, interpreted, and located the geology on the 1:24,000-scale topographic map of the Poverty Bay 7.5' quadrangle.

  8. Product (RED)

    DEFF Research Database (Denmark)

    Ponte, Stefano

    2011-01-01

    for a better world) by enrolling consumers in ways that do not rely on accurate knowledge of the products or specific understanding of the cause that The Global Fund engages but, instead, rely on a system of more general, affective affinity between the ‘aid celebrities’ who are behind RED (such as Bono...

  9. Pairing Behavior of the Monogamous King Quail, Coturnix chinensis.

    Directory of Open Access Journals (Sweden)

    Elizabeth Adkins-Regan

    Full Text Available Animals with socially monogamous mating systems are valuable for discovering proximate mechanisms of prosocial behavior and close social relationships. Especially powerful are comparisons between related species that differ in monogamous tendency. Birds are the most socially monogamous vertebrates. Thus far most research on mechanisms of pairing has used zebra finches, which do not have a relative with a different mating system, however. The goal of the experiments reported here was to develop a new comparative avian system by studying the pairing behavior of a reportedly strongly monogamous quail, the king quail (Coturnix chinensis, a species in the same clade as the less monogamous Japanese quail (Coturnix japonica, the subject of much prior research. In Experiment 1 male-female pairs of king quail housed together were initially avoidant or aggressive but most rapidly progressed to allopreening and huddling. A separation-reunion paradigm reliably elicited both of these behaviors in males that had cohabited for one week. In Experiment 2 the allopreening and huddling behavior of males in cohabiting pairs was highly selective, and a majority of the males were aggressive toward a familiar female that was not the cohabitation partner. In Experiment 3 males were separated from their female cohabitation partners for 9-10 weeks and then given two-choice tests. All but one male spent more time near an unfamiliar female, which may have reflected aggression and shows recognition of and memory for the past pairing experience. Thus king quail show robust, selective and easy to measure pairing behavior that can be reliably elicited with simple separation-reunion testing procedures. Copulation is rarely seen during tests. The behavior of king quail is a striking contrast to that of Japanese quail, providing a new comparative system for discovering mechanisms of behavior related to close social relationships and monogamy.

  10. Accumulation factors of mercury by King Bolete Boletus edulis

    Science.gov (United States)

    Falandysz, J.; Frankowska, A.

    2003-05-01

    To understand pollution picture with mercury and to examine suitability of King Bolete Boletits edulis Bull.: Fr. as possible bioindicator the total mercurv concentrations were determined both in the fruiting bodies and underlying soil substrate collected from various regions of Poland. There were quite large spatial variations of mercury concentration and some seasonal also were noted. Mercury content of the caps exceeded that of stalks (p<0.05), Nvhile Hg BCF values varied between 9 and 40, and 4 and 40, respectively.

  11. Influential factors of red-light running at signalized intersection and prediction using a rare events logistic regression model.

    Science.gov (United States)

    Ren, Yilong; Wang, Yunpeng; Wu, Xinkai; Yu, Guizhen; Ding, Chuan

    2016-10-01

    Red light running (RLR) has become a major safety concern at signalized intersection. To prevent RLR related crashes, it is critical to identify the factors that significantly impact the drivers' behaviors of RLR, and to predict potential RLR in real time. In this research, 9-month's RLR events extracted from high-resolution traffic data collected by loop detectors from three signalized intersections were applied to identify the factors that significantly affect RLR behaviors. The data analysis indicated that occupancy time, time gap, used yellow time, time left to yellow start, whether the preceding vehicle runs through the intersection during yellow, and whether there is a vehicle passing through the intersection on the adjacent lane were significantly factors for RLR behaviors. Furthermore, due to the rare events nature of RLR, a modified rare events logistic regression model was developed for RLR prediction. The rare events logistic regression method has been applied in many fields for rare events studies and shows impressive performance, but so far none of previous research has applied this method to study RLR. The results showed that the rare events logistic regression model performed significantly better than the standard logistic regression model. More importantly, the proposed RLR prediction method is purely based on loop detector data collected from a single advance loop detector located 400 feet away from stop-bar. This brings great potential for future field applications of the proposed method since loops have been widely implemented in many intersections and can collect data in real time. This research is expected to contribute to the improvement of intersection safety significantly. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Impact of Climate Change on Projected Runoff from Mountain Snowpack of the King's Rivershed in California

    Science.gov (United States)

    Dialesandro, J.; Elias, E.; Rango, A.; Steele, C. M.

    2016-12-01

    The Central Valley of California, like most dryland agricultural areas in the Southwest United States, relies heavily on winter snowpack for water resources. Projections of future climate in the Sierra Mountains of California calls for a warmer climate regime that will impact the snowpack in the Sierra Mountains and thus the water supply for downstream agriculture and municipal uses within California's Central Valley. We simulate the impacts of two future time windows (2040-2069 and 2070-2099) and two future climate scenarios (RCP 4.5 and 8.5) on King's River using the Snowmelt Runoff Model. Snow depletion curves for 2010 are generated using MODIS and SRM parameters are adjusted until measured and simulated runoff reach acceptable agreement (R2 = .81). Future projections are based upon the multimodel mean of 20 CMIP5 models for seasonal future temperature and precipitation at high and low elevation points in the watershed from the multivariate adaptive constructed analogs (MACA) downscaled dataset. Changes in monthly inflow to Pineflat Reservoir, at the pour point of King's River watersheds, show a large decline in June and July inflow for all future climate simulations. Conversely, simulated spring inflow to Pineflat Reservoir is larger in the future. Impacts are most pronounced for end of the century (2070-2099), business as usual (RCP 8.5) simulation. Results are discussed with regard to implications for reservoir storage, groundwater recharge and creative solutions to cope with anticipated changes in runoff.

  13. Re-shaping King Lear: Space, Place, Costume, and Genre

    Directory of Open Access Journals (Sweden)

    Hattaway Michael

    2017-06-01

    Full Text Available Performance studies must enjoy parity of esteem with critical studies because they remind us of the plurality of “readings” that are generated by a Shakespearean text. Shakespeare seems to have apprehended this when, in Othello, he used a nonce-word, “denotement”, which applies to Othello’s reading of his wife in his mind’s eye. I examine other sequences in which we watch a character “reading” on-stage or imagined action, in Hamlet, Titus Andronicus, Cymbeline, Richard II, and Troilus and Cressida. In Hamlet this involves re-reading as well as generic displacement, which, I argue, is a way of rendering inwardness. As I test case, I analyse a production of King Lear by Shakespeare’s Globe, on a fairground stage, in which the king reshaped himself, became a folkloric figure, like a figure in Nashe’s Summer’s Last Will and Testament. The play itself was thus, indecorously, reshaped as “The Tale of King Lear”. “Dramatic truth”, therefore, in no way depends upon theatrical “realism”.

  14. Pessoa’s myth of the King Sebastian reinterpreted

    Directory of Open Access Journals (Sweden)

    Monika Świda

    2013-01-01

    Full Text Available The present paper depicts alterations undergone by the sleeping king motif (sebastianism in the writings of Fernando Pessoa. The data to conduct the study were collected in thematic anthologies and several unpublished pieces. The myth of the King Sebastian was given a congregational dimension by Pessoa, thus conveying his cultural and identity project subsumed under the metaphor of the spiritual empire. Pessoa introduces some readjustments in the way the historical king is to be conceived of. In his theory, Sebastian becomes the figure of the individual effort on the way towards the national renewal. The messianic character of D. Sebastião is defeated in this theory despite having been associated with the figures of either Jesus or the Antichrist. The messiah of the Portuguese foundation myth is replaced with the idea of great man and the task to be carried out in this field, included the metaphor of the Fifth Empire, gains a cultural character. That is why Pessoa’s theories must no longer be interpreted in messianic terms. The Pessoa’s transformations of the sebastianism analyzed in this article are the starting point for the new national narration in the poetic cycle of "Mensagem".

  15. Ultraviolet reflecting photonic microstructures in the King Penguin beak.

    Science.gov (United States)

    Dresp, Birgitta; Jouventin, Pierre; Langley, Keith

    2005-09-22

    King and emperor penguins (Aptenodytes patagonicus and Aptenodytes forsteri) are the only species of marine birds so far known to reflect ultraviolet (UV) light from their beaks. Unlike humans, most birds perceive UV light and several species communicate using the near UV spectrum. Indeed, UV reflectance in addition to the colour of songbird feathers has been recognized as an important signal when choosing a mate. The king penguin is endowed with several highly coloured ornaments, notably its beak horn and breast and auricular plumage, but only its beak reflects UV, a property considered to influence its sexual attraction. Because no avian UV-reflecting pigments have yet been identified, the origin of such reflections is probably structural. In an attempt to identify the structures that give rise to UV reflectance, we combined reflectance spectrophotometry and morphological analysis by both light and electron microscopy, after experimental removal of surface layers of the beak horn. Here, we characterize for the first time a multilayer reflector photonic microstructure that produces the UV reflections in the king penguin beak.

  16. Removal of fumonisin B1 and B2 from model solutions and red wine using polymeric substances.

    Science.gov (United States)

    Carrasco-Sánchez, Verónica; Kreitman, Gal Y; Folch-Cano, Christian; Elias, Ryan J; Laurie, V Felipe

    2017-06-01

    Fumonisins are a group of mycotoxins found in various foods whose consumption is known to be harmful for human health. In this study, we evaluated the ability of three polymers (Polyvinylpolypyrrolidone, PVPP; a resin of N-vinyl-2-pyrrolidinone with ethylene glycol dimethacrylate and triallyl isocyanurate, PVP-DEGMA-TAIC; and poly(acrylamide-co-ethylene glycol-dimethacrylate), PA-EGDMA) to remove fumonisin B 1 (FB1) and fumonisin B 2 (FB2) from model solutions and red wine. Various polymer concentrations (1, 5 and 10mgmL -1 ) and contact times (2, 8 and 24h) were tested, with all polymers exhibiting fumonisin removal capacities (monitored by LC-MS). The impact of all polymers on polyphenol removal was also assessed. PA-EGDMA showed to be the most promising polymer, removing 71% and 95% of FB 1 , and FB 2 , respectively, with only a 22.2% reduction in total phenolics. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Accuracy of Modelled Stratospheric Temperatures in the Winter Arctic Vortex from Infra Red Montgolfier Long Duration Balloon Measurements

    Science.gov (United States)

    Pommereau, J.-P.; Garnier, A.; Knudson, B. M.; Letrenne, G.; Durand, M.; Cseresnjes, M.; Nunes-Pinharanda, M.; Denis, L.; Newman, P. A.; Einaudi, Franco (Technical Monitor)

    2000-01-01

    The temperature of the stratosphere has been measured in the Arctic vortex every 9-10 minutes along the trajectory of four Infra Red Montgolfier long duration balloons flown for 7 to 22 days during the winters of 1997 and 1999. From a number of comparisons to independent sensors, the accuracy of the measurements is demonstrated to be plus or minus 0.5 K during nighttime and at altitude below 28 km (10 hPa). The performances of the analyses of global meteorological models, European Center for Medium Range Weather Forecasts (ECMWF) 31 and 50 levels, United Kingdom Meteorological Office (UKMO), Data Assimilation Office (DAO), National Climatic Prediction Center (NCEP) and NCEP/NCAR reanalysis, used in photochemical simulations of ozone destruction and interpretation of satellite data, are evaluated by comparison to this large (3500 data points) and homogeneous experimental data set. Most of models, except ECMWF31 in 1999, do show a smal1 average warm bias of between 0 and 1.6 K, with deviations particularly large, up to 20 K at high altitude (5hPa) in stratospheric warming conditions in 1999. Particularly wrong was ECMWF 31 levels near its top level at 10 hPa in 1999 where temperature 25 K colder than the real atmosphere were reported. The average dispersion between models and measurements varies from plus or minus 1.0 to plus or minus 3.0 K depending on the model and the year. It is shown to be the result of three contributions. The largest is a long wave modulation likely caused by the displacement of the temperature field in the analyses compared to real atmosphere. The second is the overestimation of the vertical gradient of temperature particularly in warming conditions, which explains the increase of dispersion from 1997 to 1999. Unexpectedly, the third and smallest (plus or minus 0.6-0.7 K) is the contribution of meso and subgrid scale vertical and horizontal features associated to the vertical propagation of orographic or gravity waves. Compared to other

  18. The anatomy of the king crab Hapalogaster mertensii Brandt, 1850 (Anomura: Paguroidea: Hapalogastridae): new insights into the evolutionary transformation of hermit crabs into king crabs

    NARCIS (Netherlands)

    Keiler, J.; Richter, S.; Wirkner, C.S.

    2015-01-01

    The emergence of king crabs from a hermit crab-like ancestor is one of the most curious events in decapod evolution. King crabs comprise two taxa, Lithodidae and Hapalogastridae, and while lithodids have formed the focus of various anatomical studies, the internal anatomy of hapalogastrids has never

  19. Toward Inclusive Understandings of Marriage in an Early Childhood Classroom: Negotiating (Un)readiness, Community, and Vulnerability through a Critical Reading of "King and King"

    Science.gov (United States)

    Bentley, Dana Frantz; Souto-Manning, Mariana

    2016-01-01

    This collaborative classroom research study examines the ways in which preschoolers made sense of same-sex marriage through a critical reading of the book "King and King" by De Haan and Nijland. Acknowledging the importance of community in doing critical and political work, this article details the ways in which a preschool teacher and a…

  20. The effect of storage time of human red cells on intestinal microcirculatory oxygenation in a rat isovolemic exchange model

    NARCIS (Netherlands)

    Raat, N. J.; Verhoeven, A. J.; Mik, E. G.; Gouwerok, C. W.; Verhaar, R.; Goedhart, P. T.; de Korte, D.; Ince, C.

    2005-01-01

    Objective: To determine whether the storage time of human leukodepleted red blood cell concentrates compromises intestinal microvascular oxygen concentration oxygen (muPo(2)) during isovolemic exchange transfusion at low hematocrit. Design: Prospective, randomized, controlled study. Setting:

  1. When the King Becomes your Personal Enemy: W. T. Stead, King Leopold II, and the Congo Free State

    Directory of Open Access Journals (Sweden)

    Marysa Demoor

    2013-04-01

    mso-fareast-language:JA;} This paper will highlight an unknown but important episode in the life of the journalist W. T. Stead, which, intriguingly, remained unmentioned in Belgian, British, and colonial historiography. It concerns a face-to-face meeting between Stead and Leopold II, King of the Belgians, which certainly did not leave Stead the ‘friend of all Kings’, as the posthumous article published by the 'Daily Mirror' contended. Based on Stead’s own Character Sketches in the 'Review of Reviews', the paper will show how Stead’s perceptions of the scandalous government of the Congo Free State result to a large extent from his own meeting (probably towards the end of 1884 with King Leopold II, and the King’s refusal to cooperate with Britain in an improvised rescue of General Gordon in Sudan.

  2. Three Kings and the Bright Star of Fame

    Directory of Open Access Journals (Sweden)

    Emalyn J. Bullis

    2013-12-01

    Full Text Available Many phenomena in music history as well as in American history have helped develop and shape the types of music listened to today, but none have been so fresh as looking back to twentieth-century popular music and the several key individuals that “ruled” in this area. These “rulers” were hailed as “kings” firstly as a media ploy, but the American public did nothing but encourage the titles. This is somewhat confusing considering American’s pride in their democratic political system but history shows that in several key American cultural changes the “Kings” crowned in the music sphere are representative of these changes. While not difficult to determine who these individuals are, as most of them were hailed and recognized as “Kings” to their respective audiences. Benny Goodman, the King of Swing, in the 1920’s and 30’s helped usher in and popularize the Swing movement. Elvis Presley, the King of Rock and Roll, capitalized (intentionally or not on the move towards combining African-American sounds such as blues and jazz with folk, gospel, and soul, thus creating a whole new and extremely popular sound. Michael Jackson, the King of Pop, was practically born into fame with his involvement with the ‘Jackson 5,’ but that did not stop him from rising up the ladder of fame in his solo career to change the face of pop music forever. There were also many artists that surrounded these “kings,” a court, if you will, that allowed their new styles to proliferate throughout American culture, and sometimes even surpassed them musically. However, as icons, these men stand on their own for their achievements in music and their ability to change and adapt to the culture around them. By looking at the three Kings of American pop culture’s past, it is possible to see the direction of America’s culture in general from the 1920’s on and perhaps see the trajectory of music of the USA today

  3. The mechanical properties of stored red blood cells measured by a convenient microfluidic approach combining with mathematic model.

    Science.gov (United States)

    Wang, Ying; You, Guoxing; Chen, Peipei; Li, Jianjun; Chen, Gan; Wang, Bo; Li, Penglong; Han, Dong; Zhou, Hong; Zhao, Lian

    2016-03-01

    The mechanical properties of red blood cells (RBCs) are critical to the rheological and hemodynamic behavior of blood. Although measurements of the mechanical properties of RBCs have been studied for many years, the existing methods, such as ektacytometry, micropipette aspiration, and microfluidic approaches, still have limitations. Mechanical changes to RBCs during storage play an important role in transfusions, and so need to be evaluated pre-transfusion, which demands a convenient and rapid detection method. We present a microfluidic approach that focuses on the mechanical properties of single cell under physiological shear flow and does not require any high-end equipment, like a high-speed camera. Using this method, the images of stretched RBCs under physical shear can be obtained. The subsequent analysis, combined with mathematic models, gives the deformability distribution, the morphology distribution, the normalized curvature, and the Young's modulus (E) of the stored RBCs. The deformability index and the morphology distribution show that the deformability of RBCs decreases significantly with storage time. The normalized curvature, which is defined as the curvature of the cell tail during stretching in flow, suggests that the surface charge of the stored RBCs decreases significantly. According to the mathematic model, which derives from the relation between shear stress and the adherent cells' extension ratio, the Young's moduli of the stored RBCs are also calculated and show significant increase with storage. Therefore, the present method is capable of representing the mechanical properties and can distinguish the mechanical changes of the RBCs during storage. The advantages of this method are the small sample needed, high-throughput, and easy-use, which make it promising for the quality monitoring of RBCs.

  4. Four Models Including Fish, Seafood, Red Meat and Enriched Foods to Achieve Australian Dietary Recommendations for n-3 LCPUFA for All Life-Stages.

    Science.gov (United States)

    Fayet-Moore, Flavia; Baghurst, Katrine; Meyer, Barbara J

    2015-10-19

    Populations are not meeting recommended intakes of omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA). The aim was (i) to develop a database on n-3 LCPUFA enriched products; (ii) to undertake dietary modelling exercise using four dietary approaches to meet the recommendations and (iii) to determine the cost of the models. Six n-3 LCPUFA enriched foods were identified. Fish was categorised by n-3 LCPUFA content (mg/100 g categories as "excellent" "good" and "moderate"). The four models to meet recommended n-3 LCPUFA intakes were (i) fish only; (ii) moderate fish (with red meat and enriched foods); (iii) fish avoiders (red meat and enriched foods only); and (iv) lacto-ovo vegetarian diet (enriched foods only). Diets were modelled using the NUTTAB2010 database and n-3 LCPUFA were calculated and compared to the Suggested Dietary Targets (SDT). The cost of meeting these recommendations was calculated per 100 mg n-3 LCPUFA. The SDT were achieved for all life-stages with all four models. The weekly food intake in number of serves to meet the n-3 LCPUFA SDT for all life-stages for each dietary model were: (i) 2 "excellent" fish; (ii) 1 "excellent" and 1 "good" fish, and depending on life-stage, 3-4 lean red meat, 0-2 eggs and 3-26 enriched foods; (iii) 4 lean red meat, and 20-59 enriched foods; (iv) 37-66 enriched foods. Recommended intakes of n-3 LCPUFA were easily met by the consumption of fish, which was the cheapest source of n-3 LCPUFA. Other strategies may be required to achieve the recommendations including modifying the current food supply through feeding practices, novel plant sources and more enriched foods.

  5. Four Models Including Fish, Seafood, Red Meat and Enriched Foods to Achieve Australian Dietary Recommendations for n-3 LCPUFA for All Life-Stages

    Directory of Open Access Journals (Sweden)

    Flavia Fayet-Moore

    2015-10-01

    Full Text Available Populations are not meeting recommended intakes of omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA. The aim was (i to develop a database on n-3 LCPUFA enriched products; (ii to undertake dietary modelling exercise using four dietary approaches to meet the recommendations and (iii to determine the cost of the models. Six n-3 LCPUFA enriched foods were identified. Fish was categorised by n-3 LCPUFA content (mg/100 g categories as “excellent” “good” and “moderate”. The four models to meet recommended n-3 LCPUFA intakes were (i fish only; (ii moderate fish (with red meat and enriched foods; (iii fish avoiders (red meat and enriched foods only; and (iv lacto-ovo vegetarian diet (enriched foods only. Diets were modelled using the NUTTAB2010 database and n-3 LCPUFA were calculated and compared to the Suggested Dietary Targets (SDT. The cost of meeting these recommendations was calculated per 100 mg n-3 LCPUFA. The SDT were achieved for all life-stages with all four models. The weekly food intake in number of serves to meet the n-3 LCPUFA SDT for all life-stages for each dietary model were: (i 2 “excellent” fish; (ii 1 “excellent” and 1 “good” fish, and depending on life-stage, 3–4 lean red meat, 0–2 eggs and 3–26 enriched foods; (iii 4 lean red meat, and 20–59 enriched foods; (iv 37–66 enriched foods. Recommended intakes of n-3 LCPUFA were easily met by the consumption of fish, which was the cheapest source of n-3 LCPUFA. Other strategies may be required to achieve the recommendations including modifying the current food supply through feeding practices, novel plant sources and more enriched foods.

  6. Using generalized linear models to estimate selectivity from short-term recoveries of tagged red drum Sciaenops ocellatus: Effects of gear, fate, and regulation period

    Science.gov (United States)

    Burdick, Summer M.; Hightower, Joseph E.; Bacheler, Nathan M.; Paramore, Lee M.; Buckel, Jeffrey A.; Pollock, Kenneth H.

    2010-01-01

    Estimating the selectivity patterns of various fishing gears is a critical component of fisheries stock assessment due to the difficulty in obtaining representative samples from most gears. We used short-term recoveries (n = 3587) of tagged red drum Sciaenops ocellatus to directly estimate age- and length-based selectivity patterns using generalized linear models. The most parsimonious models were selected using AIC, and standard deviations were estimated using simulations. Selectivity of red drum was dependent upon the regulation period in which the fish was caught, the gear used to catch the fish (i.e., hook-and-line, gill nets, pound nets), and the fate of the fish upon recovery (i.e., harvested or released); models including all first-order interactions between main effects outperformed models without interactions. Selectivity of harvested fish was generally dome-shaped and shifted toward larger, older fish in response to regulation changes. Selectivity of caught-and-released red drum was highest on the youngest and smallest fish in the early and middle regulation periods, but increased on larger, legal-sized fish in the late regulation period. These results suggest that catch-and-release mortality has consistently been high for small, young red drum, but has recently become more common in larger, older fish. This method of estimating selectivity from short-term tag recoveries is valuable because it is simpler than full tag-return models, and may be more robust because yearly fishing and natural mortality rates do not need to be modeled and estimated.

  7. A cost effective model for appropriate administration of red cell units and salvaging un-transfused red cell units by using temperature sensitive indicators for blood component transportation in a hospital setting

    Directory of Open Access Journals (Sweden)

    Aseem K Tiwari

    2015-01-01

    Full Text Available Background: A rule called "30-min rule" defines that red cell unit cannot be used if it has been out of blood bank refrigerator for over 30 min. This rule is useful to guide initiation of transfusion, but is inadequate for deciding whether to reuse or discard units received-back at blood transfusion services (BTS. A simple cost-effective temperature-sensitive indicator was evaluated to decide upon reuse (cold chain was uninterrupted or discard (where cold chain was interrupted in a simulation exercise. Materials and Methods: Temperature-sensitive indicators TH-F™ that irreversibly changed color from white to red demonstrated that heat excursion has occurred and the cumulative temperature has exceeded 10°C for over 30 min, were used in outdated red cells for simulating units, which are not used and received-back. These units were also tagged with a standard temperature monitoring device, which was a re-usable credit card sized device, which would log the actual time and temperature. In few units percent hemolysis was also calculated. Results: Statistically insignificant elevation in average temperature was noted in 102 simulated units at the time of return to BTS (Δ 0.04°C, despite the fact that these units were in the transport box for over 4 h. The average supernatant hemoglobin in these units was 0.24%, much below the prescribed threshold. Conclusion: Transportation of blood in controlled conditions with temperature-sensitive indicator is a cost-effective model to save blood, a precious human resource.

  8. King penguin demography since the last glaciation inferred from genome-wide data.

    Science.gov (United States)

    Trucchi, Emiliano; Gratton, Paolo; Whittington, Jason D; Cristofari, Robin; Le Maho, Yvon; Stenseth, Nils Chr; Le Bohec, Céline

    2014-07-22

    How natural climate cycles, such as past glacial/interglacial patterns, have shaped species distributions at the high-latitude regions of the Southern Hemisphere is still largely unclear. Here, we show how the post-glacial warming following the Last Glacial Maximum (ca 18 000 years ago), allowed the (re)colonization of the fragmented sub-Antarctic habitat by an upper-level marine predator, the king penguin Aptenodytes patagonicus. Using restriction site-associated DNA sequencing and standard mitochondrial data, we tested the behaviour of subsets of anonymous nuclear loci in inferring past demography through coalescent-based and allele frequency spectrum analyses. Our results show that the king penguin population breeding on Crozet archipelago steeply increased in size, closely following the Holocene warming recorded in the Epica Dome C ice core. The following population growth can be explained by a threshold model in which the ecological requirements of this species (year-round ice-free habitat for breeding and access to a major source of food such as the Antarctic Polar Front) were met on Crozet soon after the Pleistocene/Holocene climatic transition. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  9. A COUPLED CHEMISTRY-EMISSION MODEL FOR ATOMIC OXYGEN GREEN AND RED-DOUBLET EMISSIONS IN THE COMET C/1996 B2 HYAKUTAKE

    Energy Technology Data Exchange (ETDEWEB)

    Bhardwaj, Anil; Raghuram, Susarla, E-mail: bhardwaj_spl@yahoo.com, E-mail: anil_bhardwaj@vssc.gov.in, E-mail: raghuramsusarla@gmail.com [Space Physics Laboratory, Vikram Sarabhai Space Centre, Trivandrum 695022 (India)

    2012-03-20

    The green (5577 Angstrom-Sign ) and red-doublet (6300, 6364 Angstrom-Sign ) lines are prompt emissions of metastable oxygen atoms in the {sup 1}S and {sup 1}D states, respectively, that have been observed in several comets. The value of the intensity ratio of green to red-doublet (G/R ratio) of 0.1 has been used as a benchmark to identify the parent molecule of oxygen lines as H{sub 2}O. A coupled chemistry-emission model is developed to study the production and loss mechanisms of the O({sup 1}S) and O({sup 1}D) atoms and the generation of red and green lines in the coma of C/1996 B2 Hyakutake. The G/R ratio depends not only on photochemistry, but also on the projected area observed for cometary coma, which is a function of the dimension of the slit used and the geocentric distance of the comet. Calculations show that the contribution of photodissociation of H{sub 2}O to the green (red) line emission is 30%-70% (60%-90%), while CO{sub 2} and CO are the next potential sources contributing 25%-50% (<5%). The ratio of the photoproduction rate of O({sup 1} S) to O({sup 1} D) would be around 0.03 ({+-}0.01) if H{sub 2}O is the main source of oxygen lines, whereas it is {approx}0.6 if the parent is CO{sub 2}. Our calculations suggest that the yield of O({sup 1} S) production in the photodissociation of H{sub 2}O cannot be larger than 1%. The model-calculated radial brightness profiles of the red and green lines and G/R ratios are in good agreement with the observations made on the comet Hyakutake in 1996 March.

  10. A COUPLED CHEMISTRY-EMISSION MODEL FOR ATOMIC OXYGEN GREEN AND RED-DOUBLET EMISSIONS IN THE COMET C/1996 B2 HYAKUTAKE

    International Nuclear Information System (INIS)

    Bhardwaj, Anil; Raghuram, Susarla

    2012-01-01

    The green (5577 Å) and red-doublet (6300, 6364 Å) lines are prompt emissions of metastable oxygen atoms in the 1 S and 1 D states, respectively, that have been observed in several comets. The value of the intensity ratio of green to red-doublet (G/R ratio) of 0.1 has been used as a benchmark to identify the parent molecule of oxygen lines as H 2 O. A coupled chemistry-emission model is developed to study the production and loss mechanisms of the O( 1 S) and O( 1 D) atoms and the generation of red and green lines in the coma of C/1996 B2 Hyakutake. The G/R ratio depends not only on photochemistry, but also on the projected area observed for cometary coma, which is a function of the dimension of the slit used and the geocentric distance of the comet. Calculations show that the contribution of photodissociation of H 2 O to the green (red) line emission is 30%-70% (60%-90%), while CO 2 and CO are the next potential sources contributing 25%-50% ( 1 S) to O( 1 D) would be around 0.03 (±0.01) if H 2 O is the main source of oxygen lines, whereas it is ∼0.6 if the parent is CO 2 . Our calculations suggest that the yield of O( 1 S) production in the photodissociation of H 2 O cannot be larger than 1%. The model-calculated radial brightness profiles of the red and green lines and G/R ratios are in good agreement with the observations made on the comet Hyakutake in 1996 March.

  11. Impact of a reduced red and processed meat dietary pattern on disease risks and greenhouse gas emissions in the UK: a modelling study

    OpenAIRE

    Aston, Louise M; Smith, James N; Powles, John W

    2012-01-01

    Objectives Consumption of red and processed meat (RPM) is a leading contributor to greenhouse gas (GHG) emissions, and high intakes of these foods increase the risks of several leading chronic diseases. The aim of this study was to use newly derived estimates of habitual meat intakes in UK adults to assess potential co-benefits to health and the environment from reduced RPM consumption. Design Modelling study using dietary intake data from the National Diet and Nutrition Survey of British Adu...

  12. Formal Thai National Costume in the Reign of King Bhumibol Adulyadej

    OpenAIRE

    Chanoknart Mayusoh

    2014-01-01

    The research about Formal Thai National Costume in the reign of King Bhumibol Adulyadej is an applied research that aimed to study the accurate knowledge concerning to Thai national costume in the reign of King Rama IX, also to study origin of all costumes in the reign of King Rama IX and to study the style, material used, and using accasion. This research methodology which are collect quanlitative data through observation, document, and photograph from key informant of costume in the reign o...

  13. Dispersal in the sub-Antarctic: king penguins show remarkably little population genetic differentiation across their range.

    Science.gov (United States)

    Clucas, Gemma V; Younger, Jane L; Kao, Damian; Rogers, Alex D; Handley, Jonathan; Miller, Gary D; Jouventin, Pierre; Nolan, Paul; Gharbi, Karim; Miller, Karen J; Hart, Tom

    2016-10-13

    Seabirds are important components of marine ecosystems, both as predators and as indicators of ecological change, being conspicuous and sensitive to changes in prey abundance. To determine whether fluctuations in population sizes are localised or indicative of large-scale ecosystem change, we must first understand population structure and dispersal. King penguins are long-lived seabirds that occupy a niche across the sub-Antarctic zone close to the Polar Front. Colonies have very different histories of exploitation, population recovery, and expansion. We investigated the genetic population structure and patterns of colonisation of king penguins across their current range using a dataset of 5154 unlinked, high-coverage single nucleotide polymorphisms generated via restriction site associated DNA sequencing (RADSeq). Despite breeding at a small number of discrete, geographically separate sites, we find only very slight genetic differentiation among colonies separated by thousands of kilometers of open-ocean, suggesting migration among islands and archipelagos may be common. Our results show that the South Georgia population is slightly differentiated from all other colonies and suggest that the recently founded Falkland Island colony is likely to have been established by migrants from the distant Crozet Islands rather than nearby colonies on South Georgia, possibly as a result of density-dependent processes. The observed subtle differentiation among king penguin colonies must be considered in future conservation planning and monitoring of the species, and demographic models that attempt to forecast extinction risk in response to large-scale climate change must take into account migration. It is possible that migration could buffer king penguins against some of the impacts of climate change where colonies appear panmictic, although it is unlikely to protect them completely given the widespread physical changes projected for their Southern Ocean foraging grounds

  14. Post-fledging dispersal of king penguins (Aptenodytes patagonicus from two breeding sites in the South Atlantic.

    Directory of Open Access Journals (Sweden)

    Klemens Pütz

    Full Text Available Most studies concerning the foraging ecology of marine vertebrates are limited to breeding adults, although other life history stages might comprise half the total population. For penguins, little is known about juvenile dispersal, a period when individuals may be susceptible to increased mortality given their naïve foraging behaviour. Therefore, we used satellite telemetry to study king penguin fledglings (n = 18 from two sites in the Southwest Atlantic in December 2007. The two sites differed with respect to climate and proximity to the Antarctic Polar Front (APF, a key oceanographic feature generally thought to be important for king penguin foraging success. Accordingly, birds from both sites foraged predominantly in the vicinity of the APF. Eight king penguins were tracked for periods greater than 120 days; seven of these (three from the Falkland Islands and four from South Georgia migrated into the Pacific. Only one bird from the Falkland Islands moved into the Indian Ocean, visiting the northern limit of the winter pack-ice. Three others from the Falkland Islands migrated to the eastern coast of Tierra del Fuego before travelling south. Derived tracking parameters describing their migratory behaviour showed no significant differences between sites. Nevertheless, generalized linear habitat modelling revealed that juveniles from the Falkland Islands spent more time in comparatively shallow waters with low sea surface temperature, sea surface height and chlorophyll variability. Birds from South Georgia spent more time in deeper waters with low sea surface temperature and sea surface height, but high concentrations of chlorophyll. Our results indicate that inexperienced king penguins, irrespective of the location of their natal site in relation to the position of the APF, develop their foraging skills progressively over time, including specific adaptations to the environment around their prospective breeding site.

  15. Hedging in Political Discourse: Evidence from the Speeches of King Abdullah II of Jordan

    OpenAIRE

    Rabab’ah Ghaleb; Abu Rumman Ronza

    2015-01-01

    This paper reports on the findings of a study that aimed to identify the linguistic items which act as hedges in the speeches of King Abdullah II of Jordan, as well as to examine the pragmatic functions of these devices. Twenty-five political speeches of King Abdullah II, randomly selected from the official website of King Abdullah (see Appendix), were analyzed adopting Salager-Meyer’s (1994) taxonomy. The study revealed that the most frequently used hedging device in King Abdullah’s speech i...

  16. Geochemical interpretation of Kings Mountain, North Carolina, orientation area

    International Nuclear Information System (INIS)

    Price, V.; Ferguson, R.B.

    1977-01-01

    An orientation study has been made of uranium occurrences in the area of Kings Mountain, North Carolina. This is one of the orientation studies of known uranium occurrences that are being conducted in several geologic provinces and under various climatic (weathering) conditions to provide the technical basis for design and interpretation of NURE geochemical reconnaissance programs. The Kings Mountain area was chosen for study primarily because of the reported presence of high-uranium monazite. This 750-mi 2 area is in the deeply weathered southern Appalachian Piedmont and spans portions of the Inner Piedmont, Kings Mountain, and Charlotte geologic belts. Uranium concentration maps for ground and surface water samples clearly outline the outcrop area of the Cherryville Quartz Monzonite with highs up to 10 ppb uranium near the reported uraninite. Several surface water samples appear to be anomalous because of trace industrial contamination. Uranium concentration maps for -100 to +200 mesh stream sediments indicate the area of monazite abundance. Several samples with >100 ppM uranium content appear to be high in uranium-rich resistate minerals. When the uranium content of sediment samples is ratioed to the sum of Hf, Dy, and Th, the anomaly pattern shifts to coincide with uranium highs in ground and surface water samples. False anomalies from concentrations of monazite (Ce,ThPO 4 ), xenotime (Y,DyPO 4 ), and zircon (Zr,HfSiO 4 ) in stream sediment samples can thus be eliminated. Residual anomalies should be related to unusual uranium enrichment of these common minerals or to the presence of an uncommon uranium-rich mineral. Tantalum, beryllium, and tin in stream sediments correspond to high concentrations of uranium in stream and ground water but not to uranium in sediments. In an initial reconnaissance, several media should be sampled, and it is essential to correct uranium in sediments for the sample mineralogy

  17. Outliers and Extremes: Dragon-Kings or Dragon-Fools?

    Science.gov (United States)

    Schertzer, D. J.; Tchiguirinskaia, I.; Lovejoy, S.

    2012-12-01

    Geophysics seems full of monsters like Victor Hugo's Court of Miracles and monstrous extremes have been statistically considered as outliers with respect to more normal events. However, a characteristic magnitude separating abnormal events from normal ones would be at odd with the generic scaling behaviour of nonlinear systems, contrary to "fat tailed" probability distributions and self-organized criticality. More precisely, it can be shown [1] how the apparent monsters could be mere manifestations of a singular measure mishandled as a regular measure. Monstrous fluctuations are the rule, not outliers and they are more frequent than usually thought up to the point that (theoretical) statistical moments can easily be infinite. The empirical estimates of the latter are erratic and diverge with sample size. The corresponding physics is that intense small scale events cannot be smoothed out by upscaling. However, based on a few examples, it has also been argued [2] that one should consider "genuine" outliers of fat tailed distributions so monstrous that they can be called "dragon-kings". We critically analyse these arguments, e.g. finite sample size and statistical estimates of the largest events, multifractal phase transition vs. more classical phase transition. We emphasize the fact that dragon-kings are not needed in order that the largest events become predictable. This is rather reminiscent of the Feast of Fools picturesquely described by Victor Hugo. [1] D. Schertzer, I. Tchiguirinskaia, S. Lovejoy et P. Hubert (2010): No monsters, no miracles: in nonlinear sciences hydrology is not an outlier! Hydrological Sciences Journal, 55 (6) 965 - 979. [2] D. Sornette (2009): Dragon-Kings, Black Swans and the Prediction of Crises. International Journal of Terraspace Science and Engineering 1(3), 1-17.

  18. Red Sky

    OpenAIRE

    Young, John

    2015-01-01

    Red Sky is scored for alto flute (Kingma system), Clarinet in B-flat/bass clarinet), piano and 14 channel digital audio files (48 kHz/24 bit). A MAX patch for triggering the sound files in performance is available. Permission to include oral history recordings of First World War survivors was kindly granted by the Imperial War Museum, London. The work was created to mark the close of the New Walk Museum and Art Gallery’s ‘Leicester at War 1914-15’ exhibition. The work is in 31 movem...

  19. Climate-driven range shifts of the king penguin in a fragmented ecosystem

    Science.gov (United States)

    Cristofari, Robin; Liu, Xiaoming; Bonadonna, Francesco; Cherel, Yves; Pistorius, Pierre; Le Maho, Yvon; Raybaud, Virginie; Stenseth, Nils Christian; Le Bohec, Céline; Trucchi, Emiliano

    2018-02-01

    Range shift is the primary short-term species response to rapid climate change, but it is often hampered by natural or anthropogenic habitat fragmentation. Different critical areas of a species' niche may be exposed to heterogeneous environmental changes and modelling species response under such complex spatial and ecological scenarios presents well-known challenges. Here, we use a biophysical ecological niche model validated through population genomics and palaeodemography to reconstruct past range shifts and identify future vulnerable areas and potential refugia of the king penguin in the Southern Ocean. Integrating genomic and demographic data at the whole-species level with specific biophysical constraints, we present a refined framework for predicting the effect of climate change on species relying on spatially and ecologically distinct areas to complete their life cycle (for example, migratory animals, marine pelagic organisms and central-place foragers) and, in general, on species living in fragmented ecosystems.

  20. Burger King in Portugal : to lead or to follow?

    OpenAIRE

    Patrone, Sara Saraiva

    2012-01-01

    In 2001, the Burger King (BK) brand, managed by Ibersol group entered the growing fast food Portuguese market. Marginally higher prices along with the fact of having entered the market 10 years after its most direct competitor (McDonald´s), led BK to a sub leader position. Although being recognized as offering superior quality products when compared to McDonald´s, BK´s growth margins in the Portuguese market have been decreasing since 2007. The company´s uncertainty situation, offers the p...

  1. Martin Luther King, Jr., General Hospital and community involvement.

    Science.gov (United States)

    Humphrey, M M

    1973-07-01

    Community involvement is not just one facet of the new Martin Luther King, Jr., General Hospital's existence. It is the mainstream from which all other activities flow. In addition to meeting the conventional needs of a conventional hospital staff with the core collection of texts and journals, this library goes one step further. It acts as a resource for its community health workers, dietitians, and nurses in their various outreach programs. It serves as a stimulus for the high school or community college student who may be curious about a health career. It also finds time to provide reading material for its patients.

  2. Fish for peasants and kings - a Danish perspective

    DEFF Research Database (Denmark)

    Kristiansen, Mette Svart

    2011-01-01

    Fish played an important role in medieval Europe. It formed the basis of a food culture influenced by Catholicism and was a central commodity in the national and international network of trade. Fish of all sorts held a prominent position on the dining tables of peasants as well as kings. Household...... accounts and medieval recipes and descriptions of dinners give us a glimpse of a variety of fresh, salted, air-dried and smoked fish and ways of preparing and serving them. The archaeological evidence from excavations on monasteries and castles, in towns and villages support this picture of variety...

  3. 77 FR 53179 - North Pacific Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-08-31

    ... specifications for Eastern Bering Sea (EBS) snow crab, Tanner crab, Saint Matthew blue king crab, Pribilof... discussions include model recommendations for Aleutian Islands golden king crab, Norton Sound red king crab...

  4. Modeling temperature effect on dynamic modulus of elasticity of red pine (Pinus resinosa) in frozen and non-frozen states

    Science.gov (United States)

    Shan Gao; Xiping Wang; Lihai Wang

    2015-01-01

    The response of dynamic and static modulus of elasticity (MOEdyn and MOEsta) of red pine small clear wood (25.4 × 25.4 × 407 mm3) within the temperature range -40 to 40°C has been investigated. The moisture content (MC) of the specimens ranged from 0 to 118%. The MOEdyn was...

  5. Nutrient (N, P, Si) transfers in the subtropical Red River system (China and Vietnam): Modelling and budget of nutrient sources and sinks

    Science.gov (United States)

    Le, Thi Phuong Quynh; Gilles, Billen; Garnier, Josette; Sylvain, Théry; Denis, Ruelland; Anh, Nghiem Xuan; Minh, Chau Van

    2010-02-01

    The Red River system, which has a population density that varies from 80 to over 1000 inhabitants km -2 in the different sectors of its watershed, is a typical example of a subtropical system experiencing high human pressure. A monthly survey of nutrient concentration was conducted at the outlet of the three main tributaries (Da, Thao and Lo) and at Hanoi on the main branch of the Red River in the upper part of the delta. Samples from headwater streams or irrigation channels draining homogeneous land use classes also were analysed. A GIS database describing the characteristics of the watershed in terms of morphology, climate, land use and population has been established. This served as the basis for implementing the Seneque/Riverstrahler model, which allowed calculation of nutrient transfers and transformations along the whole drainage network of the Red River system. The model was validated using the measured nutrient concentrations obtained during the survey and was used to establish an overall description and a comprehensive budget of nutrient transfer, retention and delivery for the three main sub-basins and the upper part of the delta upstream from Hanoi.

  6. The Drainage Consolidation Modeling of Sand Drain in Red Mud Tailing and Analysis on the Change Law of the Pore Water Pressure

    Directory of Open Access Journals (Sweden)

    Chuan-sheng Wu

    2014-01-01

    Full Text Available In order to prevent the occurring of dam failure and leakage, sand-well drainages systems were designed and constructed in red mud tailing. It is critical to focus on the change law of the pore water pressure. The calculation model of single well drainage pore water pressure was established. The pore water pressure differential equation was deduced and the analytical solution of differential equation using Bessel function and Laplace transform was given out. The impact of parameters such as diameter d, separation distance l, loading rate q, and coefficient of consolidation Cv in the function on the pore water pressure is analyzed by control variable method. This research is significant and has great reference for preventing red mud tailings leakage and the follow-up studies on the tailings stability.

  7. King Lear Reveals the Tragic Pattern of Shakespeare

    Directory of Open Access Journals (Sweden)

    Salim Eflih Al-Ibia

    2017-04-01

    Full Text Available Rather than focusing on the obvious traditions of evaluating Shakespearean tragic heroes, this paper presents a groundbreaking approach to unfold the pattern William Shakespeare follows as he designed his unique characters. This pattern applies to most, if not all, Shakespearean tragic heroes. I argue that Shakespeare himself reveals a great portion of this pattern on the tongue of Lear as the latter disowns Goneril and Regan promising to have “such revenges on [them] both” in King Lear. Lear’s threats bestow four unique aspects that apply not only to his character but they also apply to Shakespearean tragic heroes. Lear’s speech tells us that he is determined to have an awful type of revenge on his daughters. However, the very same speech tells us that he seems uncertain about the method through which he should carry out this revenge. Lear does not express any type of remorse as he pursues his vengeful plans nor should he aim at amnesty. He also admits his own madness as he closes his revealing speech. This research develops these facts about Lear to unfold the unique pattern Shakespeare follows as he portrayed his major tragic figures. This pattern is examined, described and analyzed in King Lear, Othello, and Hamlet. We will find out that the pattern suggested in this study helps us better understand Shakespeare’s tragedies and enables us to provide better explanations for some controversial scenes in the tragedies discussed.

  8. King County Metro Battery Electric Bus Demonstration: Preliminary Project Results

    Energy Technology Data Exchange (ETDEWEB)

    2017-05-22

    The U.S. Federal Transit Administration (FTA) funds a variety of research projects that support the commercialization of zero-emission bus technology. To evaluate projects funded through these programs, FTA has enlisted the help of the National Renewable Energy Laboratory (NREL) to conduct third-party evaluations of the technologies deployed under the FTA programs. NREL works with the selected agencies to evaluate the performance of the zero-emission buses compared to baseline conventional buses in similar service. The evaluation effort will advance the knowledge base of zero-emission technologies in transit bus applications and provide 'lessons learned' to aid other fleets in incrementally introducing next generation zero-emission buses into their operations. This report provides preliminary performance evaluation results from a demonstration of three zero-emission battery electric buses at King County Metro in King County, Washington. NREL developed this preliminary results report to quickly disseminate evaluation results to stakeholders. Detailed evaluation results will be published in future reports.

  9. King penguins can detect two odours associated with conspecifics.

    Science.gov (United States)

    Cunningham, Gregory B; Bonadonna, Francesco

    2015-11-01

    Recent studies on olfaction in penguins have focused on their use of odours while foraging. It has been proposed for some seabirds that an olfactory landscape shaped by odours coming from feeding areas exists. Islands and colonies, however, may also contribute to the olfactory landscape and may act as an orienting map. To test sensitivities to a colony scent we studied whether King penguins (Aptenodytes patagonicus) could detect the smell of sand, feathers or feces by holding presentations beneath their beaks while they naturally slept on the beach. Penguins had a significantly greater response to the feathers and feces presentations than to sand. Although only a first step in exploring a broader role of olfaction in this species, our results raise the possibility of olfaction being used by King penguins in three potential ways: (1) locating the colony from the water or the shore, (2) finding the rendezvous zone within the colony where a chick or partner may be found, or (3) recognizing individuals by scent, as in Humboldt penguins (Spheniscus demersus). © 2015. Published by The Company of Biologists Ltd.

  10. Structural organisation and dynamics in king penguin colonies

    Science.gov (United States)

    Gerum, Richard; Richter, Sebastian; Fabry, Ben; Le Bohec, Céline; Bonadonna, Francesco; Nesterova, Anna; Zitterbart, Daniel P.

    2018-04-01

    During breeding, king penguins do not build nests, however they show strong territorial behaviour and keep a pecking distance to neighbouring penguins. Penguin positions in breeding colonies are highly stable over weeks and appear regularly spaced, but thus far no quantitative analysis of the structural order inside a colony has been performed. In this study, we use the radial distribution function to analyse the spatial coordinates of penguin positions. Coordinates are obtained from aerial images of two colonies that were observed for several years. Our data demonstrate that the structural order in king penguin colonies resembles a 2D liquid of particles with a Lennard-Jones-type interaction potential. We verify this using a molecular dynamics simulation with thermally driven particles, whereby temperature corresponds to penguin movements, the energy well depth ɛ of the attractive potential corresponds to the strength of the colony-forming behaviour, and the repulsive zone corresponds to the pecking radius. We can recapitulate the liquid disorder of the colony, as measured by the radial distribution function, when the particles have a temperature of several (1.4–10) \

  11. FROM DAVID T0 SOLOMON (1 KINGS 1-2): AN AFRICAN ...

    African Journals Online (AJOL)

    JOURNAL OF PHILOSOPHY A ND (Y ]L HIRE. Bathsheba, 'fSolomon your son shall reign after me, and shall sit upon my throne in my stead” (1 Kings .... the likelihood is that the designated person may murder the incumbent to hasten his ascension to the throne32 In almost all societies the king was the embodiment of the ...

  12. The King James Bible and the Politics of Religious Education: Secular State and Sacred Scripture

    Science.gov (United States)

    Gearon, Liam

    2013-01-01

    This article provides an outline historical-educational analysis of the King James Bible from its 1611 publication through to its four-hundredth anniversary commemoration in 2011. With particular focus on England, the article traces the educational impact of the King James Bible and charts, in the country of its origin, its progressive decline in…

  13. Connect the Book. Martin's Big Words: The Life of Dr. Martin Luther King, Jr.

    Science.gov (United States)

    Brodie, Carolyn S.

    2005-01-01

    In honor of Martin Luther King, Jr. Day, this month's featured book is "Martin's Big Words: The Life of Dr. Martin Luther King, Jr." The book was written by Doreen Rappaport and illustrated by Bryan Collier (Jump at the Sun, 2001. 40p. ISBN 0786807148). This pictorial biography of the world-renowned civil rights leader has one of the most striking…

  14. Whatsapp for Educational Purposes for Female Students at College of Education--King Saud University

    Science.gov (United States)

    Aljaad, Nawal Hamad Mohmad

    2017-01-01

    This research aims at finding out the educational usages of "Whatsapp" by the Saudi female students who are involved in the College of Education at King Saud University. To achieve the goal of this study, the researcher uses a simple sample of (122) female students from the Education College of King Saud University, which is chosen…

  15. Rufus King: Soldier-Statesmen of the Constitution. A Bicentennial Series No. 15.

    Science.gov (United States)

    Army Center of Military History, Washington, DC.

    Throughout a lengthy public career, Rufus King employed his considerable diplomatic and oratorical skills to promote the twin causes of nationalism and civil liberty, fighting in the last decade of his life to extend those liberties to the nation's enslaved black minority. This booklet on King is one in a series on veterans of the Revolutionary…

  16. The Conceptualization of God's Dwelling Place in 1 Kings 8: A Cognitive Approach.

    NARCIS (Netherlands)

    Kamp, A.H.

    2016-01-01

    The diversity of terms for God's dwelling place in 1 Kings 8 is generally ascribed to a number of text traditions in which different theological views of the temple and God's dwelling place dominate. Rather than taking a fragmented view, this study starts from the textual integrity of 1 Kings 8. It

  17. Modeling Radial Velocities and Eclipse Photometry of the Kepler Target KIC 4054905: an Oscillating Red Giant in an Eclipsing Binary

    Science.gov (United States)

    Benbakoura, M.; Gaulme, P.; McKeever, J.; Beck, P. G.; Jackiewicz, J.; García, R. A.

    2017-12-01

    Asteroseismology is a powerful tool to measure the fundamental properties of stars and probe their interiors. This is particularly efficient for red giants because their modes are well detectable and give information on their deep layers. However, the seismic relations used to infer the mass and radius of a star have been calibrated on the Sun. Therefore, it is crucial to assess their accuracy for red giants which are not perfectly homologous to it. We study eclipsing binaries with a giant component to test their validity. We identified 16 systems for which we intend to compare the dynamical masses and radii obtained by combined photometry and spectroscopy to the values obtained from asteroseismology. In the present work, we illustrate our approach on a system from our sample.

  18. The effect of supplementation with three commercial inactive dry yeasts on the colour, phenolic compounds, polysaccharides and astringency of a model wine solution and red wine.

    Science.gov (United States)

    González-Royo, Elena; Esteruelas, Mireia; Kontoudakis, Nikolaos; Fort, Francesca; Canals, Joan Miquel; Zamora, Fernando

    2017-01-01

    Nowadays supplementing red wines with commercial inactive dry yeasts is a widespread practice in winemaking because it leads to better balanced wines through increased mouthfeel and smooth astringency. The aim of this article is to study, in a red wine and in a model wine solution, how supplementation with three commercial inactive dry yeasts affects chemical composition and astringency. This will give us a better understanding of the action mechanism involved. The results suggest that this action mechanism is related to two different phenomena. The first is that inactive yeasts release polysaccharides and oligosaccharides which can increase mouthfeel and inhibit interactions between salivary protein and tannins. The second is that they have a direct effect on the precipitation or absorption of proanthocyanidins, especially the larger polymers, which have been described as the most astringent. It can be concluded that supplementation with inactive yeasts is indeed a useful tool for smoothing the astringency of red wines. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  19. Evaluation of estrogenic activity of red clover (Trifolium pratense L.) sprouts cultivated under different conditions by content of isoflavones, calorimetric study and molecular modelling.

    Science.gov (United States)

    Budryn, Grażyna; Gałązka-Czarnecka, Ilona; Brzozowska, Ewelina; Grzelczyk, Joanna; Mostowski, Radosław; Żyżelewicz, Dorota; Cerón-Carrasco, José P; Pérez-Sánchez, Horacio

    2018-04-15

    Isoflavones have an affinity for estrogen receptors (ERs) including beneficial affinity for ERβ. Widely used soy is a source of poorly absorbed isoflavones glycosides. Red clover contains mostly easily absorbed free aglycones. Red clover sprouts were cultivated under different conditions (white light, UVA or UVB for 12 or 24 h a day at 18 or 25 °C) to maximise the content of isoflavones, especially of high affinity for ERβ. The affinity of isoflavones to ERs was evaluated by molecular modelling and isothermal titration calorimetry (ITC). The richest source of isoflavones, especially formononetin were sprouts cultivated for 10 days under continuous white light and at 25 °C (562 mg/100 g of fresh mass). Formononetin and the above sprouts has been shown to have a high affinity for ERβ. Red clover sprouts can be considered as a source of phytoestrogens with high biological activity and as a dietary supplement reducing menopausal symptoms. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Theoretical investigation and mathematical modelling of a wind energy system case study for Mediterranean and Red Sea

    Energy Technology Data Exchange (ETDEWEB)

    Shata, Ahmed Shata Ahmed

    2008-06-26

    Fossil fuel is getting more and more expensive every year, and is not readily available in some remote locations. Today, wind power can be harnessed to provide some or all of the power for many useful tasks such as generating electricity, pumping water and heating a house or barn. Egypt has two coastal areas that show significant promise for wind energy exploitation; the north coast on the Mediterranean Sea and the east coast on the Red Sea. The wind energy is utilized along the coast of Mediterranean Sea in Egypt on few occasions, while from national programs for wind energy utilization in Egypt, at the Red Sea coast, the master plan calls for 600 MW which are expected to be achieved by the year 2005. The contribution of fossil fuels (oil and natural gas) to electricity production in Egypt accounts for about 79% of total production, while 21% is hydropower. The demand is expected to grow rapidly to meet the large requirements of future projects. Studies showed that there is an additional need of annual electricity generation capacity around 1000 MW/year up to 2017 [14]. The purpose of this thesis is to present a new analytical method for the calculation of the wind energy potential available along the north coast of the Mediterranean Sea and the east coast of Red Sea in Egypt and moreover, it estimates the possible electrical power generated by large wind turbines and the expected cost in Euro cent/kWh for the power level of 2000 kW. It is hoped that the data analysis will help to identify good sites in Egypt for new wind turbine installations. This evaluation is hoped to trigger the use of large wind turbines at the selected sites along the coasts of Mediterranean Sea and Red Sea in Egypt. (orig.)

  1. A multiscale Cauchy-Born meshfree model for deformability of red blood cells parasitized by Plasmodium falciparum

    Science.gov (United States)

    Zhang, L. W.; Ademiloye, A. S.; Liew, K. M.

    In normal physiological and healthy conditions, red blood cells (RBCs) deform readily as they pass through the microcapillaries and the spleen, however, upon invasion by the malaria parasite, the host RBC membrane begins to lose their deformability. In spite of the progress in understanding malaria pathogenesis, the primary mechanism responsible for the loss of deformability remains unclear. In this paper, we examine the effects of Plasmodium falciparum infection and maturation on the deformability of parasitized or infected red blood cells (iRBCs) by means of a three-dimensional (3D) multiscale red blood cell (RBC) framework. This multiscale framework is developed based on the Cauchy-Born rule and the meshfree IMLS-Ritz method. The atomistic scale strain energy density function of the RBC membrane was computed using a selected representative cell based on the membrane spectrin network. The results obtained from our numerical simulations affirm that the presence of malaria infection significantly increases the rigidity of RBC membrane. It was observed that in the trophozoite and schizont infection stages, biconcave cell geometry leads to better prediction than nearly spherical geometry in comparison with experimental studies. Furthermore, we confirm that increase in temperature also results to increased stiffening of the cell membrane. Lastly, the observed decrease in the deformability of iRBC membrane may be primarily due to the structural remodeling and changes in the microstructure of the membrane rather than the change in cell shape.

  2. Past, current, and future trends of red spiny lobster based on PCA with MaxEnt model in Galapagos Islands, Ecuador.

    Science.gov (United States)

    Moya, Wladimir; Jacome, Gabriel; Yoo, ChangKyoo

    2017-07-01

    In order to enhance in terms of accuracy and predict the modeling of the potential distribution of species, the integration of using principal components of environmental variables as input of maximum entropy (MaxEnt) has been proposed in this study. Principal components selected previously from the principal component analysis results performed in ArcGIS in the environmental variables was used as an input data of MaxEnt instead of raw data to model the potential distribution of red spiny lobster from the year 1997 to 2015 and for three different future scenarios 2020, 2050, and 2070. One set of six original environmental variables pertaining to the years 1997-2015 and one set of four variables for future scenarios were transformed independently into a single multiband raster in ArcGIS in order to select the variables whose eigenvalues explains more than 5% of the total variance with the purpose to use in the modeling prediction in MaxEnt. The years 1997 and 1998 were chosen to compare the accuracy of the model, showing better results using principal components instead of raw data in terms of area under the curve and partial receiver operating characteristic as well as better predictions of suitable areas. Using principal components as input of MaxEnt enhances the prediction of good habitat suitability for red spiny lobster; however, future scenarios suggest an adequate management by researches to elaborate appropriate guidelines for the conservation of the habitat for this valuable specie with face to the climate change.

  3. 76 FR 5326 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; King and Spanish Mackerel Coastal...

    Science.gov (United States)

    2011-01-31

    ... Spanish Mackerel Coastal Migratory Pelagic Fishery Off the Southern Atlantic States; Control Date AGENCY... that it is establishing a new control date to control future access to the king and Spanish mackerel... September 17, 2010, for king and Spanish mackerel. The Council requested a new control date for the king and...

  4. Biological Activities and Phytochemicals of Swietenia macrophylla King

    Directory of Open Access Journals (Sweden)

    Habsah Abdul Kadir

    2013-08-01

    Full Text Available Swietenia macrophylla King (Meliaceae is an endangered and medicinally important plant indigenous to tropical and subtropical regions of the World. S. macrophylla has been widely used in folk medicine to treat various diseases. The review reveals that limonoids and its derivatives are the major constituents of S. macrophylla. There are several data in the literature indicating a great variety of pharmacological activities of S. macrophylla, which exhibits antimicrobial, anti-inflammatory, antioxidant effects, antimutagenic, anticancer, antitumor and antidiabetic activities. Various other activities like anti-nociceptive, hypolipidemic, antidiarrhoeal, anti-infective, antiviral, antimalarial, acaricidal, antifeedant and heavy metal phytoremediation activity have also been reported. In view of the immense medicinal importance of S. macrophylla, this review aimed at compiling all currently available information on its ethnomedicinal uses, phytochemistry and biological activities of S. macrophylla, showing its importance.

  5. The stoning in Bible: King David’s case

    OpenAIRE

    Priede, Janis

    2008-01-01

    In the Old Testament, the stoning is said to be the instinctive, violent expression of popular wrath (Ex 17:4, 8:22; Num 14:10; 1 Sam 30:6; 1 Kings 12:18; 2 Chron 10:18), and is often expressly prescribed as a mode of execution (Lev 20:2, 27, 24:16; Num 15:35; Deut 13:11, 17:5, 21:21, 22:21 et al.). As the survival of vindicta publica (C o h n 1996, 142), it was characterized by the active participation of the whole population (Lev 24:16; Num 15:35; Deut 17:7; et al.), all the people had to p...

  6. [The vicissitude of Huangjing (rhizome of king solomonseal) germplasm].

    Science.gov (United States)

    Cheng, Ming-en; Wang, De-qun

    2009-01-01

    Huangjing (rhizome of king solomonseal), originally recorded in Ming yi bie lu involved several kinds of Polygonatum plant. The Huangjing of Northern and Southern dynasties was derived from rhizome nodular groups of Polygonatum plant. In Tang and Song dynasties, the verticillate leaf group of Polygonatum plant was enthroned especially the Polygonati sibiricum Delar. ex Redoute and formed the genuine productive area: Songshan and Maoshan. Such situation continued until Ming dynasty. After Qing dynasty, alternate leaf group together with verticillate leaf group became the main variety of Polygonatum herb. In the period of republic of China, the Polygonatum cyrtonema Hua of alternate leaf group developed into the main stream of Medicinal Huangjing and finally formed the medicated situation of two kinds of groups of this time.

  7. Robert King Merton (1910-2003 -In Memoriam

    Directory of Open Access Journals (Sweden)

    Carlos Uribe Celis

    2003-07-01

    Full Text Available RObert King Merton (1910-2003 fue uno de los sociólogos más connotados y representativos de la disciplina sociológica en el siglo XX. Ciertamente es uno de los grandes sociólogos norteamericanos, si no el mayor después de Talcott Parsons, su maestro. Y no olvidemos que la sociología fue llamada al giro del siglo XIX: la "Ciencia Americana". Al tiempo de su muerte -apunta Erwin K. Scheuch en una nota obituaria reciente-la obra de Merton había recibido 17.500 citas en revistas de ciencias y humanidades censadas a este propósito', una estadística muy elocuente de su muy amplia influencia intelectual.

  8. THE QUEST FOR KNOWLEDGE IN "THE KING JAMES BIBLE"

    Directory of Open Access Journals (Sweden)

    Ewa Piotrowska-Oberda

    2014-10-01

    Full Text Available The aim of this article is the quest for knowledge in "The King James Bible" (1611 in terms of quantitative and qualitative research methodology with the application of the statistical analysis tool Antconc. The quest for knowledge with the use of corpus research aims at discussing the Biblical concept of knowledge through the origin, the object of knowledge, its implications and its constant development. Knowledge is often seen as of divine nature, reflected in the soul of man. It is based not only on logical, but also on the spiritual and ethical reasoning. The object of knowledge is light, reflecting the divine nature of knowledge which exceeds the intellect to reach a deeper spiritual human reasoning. In "The King James Bible" (1611 the authors of New Testament consider human knowledge to be imperfect and partial. They emphasize the need for a spiritual man aiming at reaching a complete knowledge. This spiritual development is based on the relationship between knowledge and faith, as well as knowledge and love. For the authors of the books of the New Testament there is no dichotomy between both knowledge and faith and knowledge and love, because faith and love depend on knowledge that originates in the word of God and leads to spiritual development. From this perspective, religious knowledge, love and mercy as well as faith developed through the knowledge of the biblical text leads to the knowledge of God, the enlightening source of ultimate knowledge. Thus, in the spiritual development of man not only the knowledge and faith but also emotional intelligence, which expresses itself through love and charity as the safer guide in all controversial issues, are important.

  9. Red Sea as a source for bioprospecting

    KAUST Repository

    Kodzius, Rimantas

    2015-12-12

    King-Abdullah University of Science and Technology (KAUST) is located on the shores of the Red Sea in Saudi Arabia. The Red Sea is well known for its unique environment, harboring various microbes capable of surviving in salty brines. We collected sediment samples from brine pool adjacent to the Thuwal cold seeps in the Red Sea. The taxonomic analysis showed the diversity and abundance of bacterial and archaeal operational taxonomic units (OUT). Recently we established in the laboratory a microdroplet technology to encapsulate single cells. This technology enables us to analyze single-cell genomes and perform the high-throughput screening. The genomes of both cultivable and uncultivable organisms can be analyzed. We envision the collection of complimentary data, obtained by various techniques, such as single-cell genomics, metagenomics, and transcriptomics. That will enable us not only to understand the environment and microorganism communities but also will allow to discover the previously unknown genes, pathways, and whole genomes. These data will facilitate the enhancement of biological and chemical producers, and pave the way for bioprospecting.

  10. Low-level red LED light inhibits hyperkeratinization and inflammation induced by unsaturated fatty acid in an in vitro model mimicking acne.

    Science.gov (United States)

    Li, Wen-Hwa; Fassih, Ali; Binner, Curt; Parsa, Ramine; Southall, Michael D

    2018-02-01

    Acne vulgaris is a chronic inflammatory disease of the pilosebaceous units (PSU), associated with increased sebum production, abnormal follicular keratinization (hyperkeratinization), follicular overgrowth of Propionibacterium acnes (P. acnes), and increased inflammatory mediator release. Light therapy has attracted medical interests as a safe alternative treatment for acne. Both blue and red light therapies at high doses >10 J/cm 2 have demonstrated marked effects on inflammatory acne lesions. However, few studies have investigated the effects of lower doses of light. The aim of this study is to investigate the biological effects of lower doses of red light at 0.2-1.2 J/cm 2 for acne using an in vitro model previously developed to mimic the inflammation and hyperkeratinization observed clinically in acne. Human epidermal equivalents were topically exposed to an unsaturated fatty acid, oleic acid (OA), followed by red light-emitting diode (LED) light treatments (light-plus-OA treatments). Endpoints evaluated included the proinflammatory cytokine IL-1α, epidermal barrier integrity, as measured by transepithelial electrical resistance (TEER), and stratum corneum (SC) thickness to monitor hyperkeratinization. OA-induced IL-1α release was significantly (P LED light at 0.2, 0.5, and 1.2 J/cm 2 , from 266 ± 11 pg/ml of no-light-plus-OA-treated (OA treatment without light) controls to 216 ± 9, 231 ± 8, and 212 ± 7 pg/ml, respectively. Histological examination showed that SC thickening following OA treatment was reduced from 43% of total epidermis for no-light-plus-OA treatment to 37% and 38% of total epidermis following 0.5 and 1.1 J/cm 2 red light plus OA treatment, respectively (P light-plus-OA treatment improved OA-induced TEER changes from 29% of baseline for no-light-plus-OA treatment, to 36% of baseline. Low level red LED light therapy could provide beneficial effects of anti-inflammation, normalizing pilosebaceous

  11. The philosophical premises of the second King Report on corporate governance

    Directory of Open Access Journals (Sweden)

    G.J. Rossouw

    2005-07-01

    Full Text Available This article focuses on the philosophical presuppositions of the second King Report on corporate governance for South Africa (hereafter referred to as the King II Report. Especially in the “Introduction and Background” section of the King II Report it is clear that the Report is premised upon a specific understanding of the present-day corporation and its moral obligations. The purpose of this article is to commit what Charles Taylor called “an act of retrieval” in which the philosophical premises of the King II Report will be unearthed and exposed. It will be argued that the view of the present-day corporation that underlies the King II Report could be related back to a number of debates on the notion of the comtemporary corporation and its moral responsibilities that have been played out since the 1970s. It will be indicated how these debates provide the philosophical foundations for the view of the comtemporary corporation and its moral obligations that is espoused in the King II Report. The claim made in the Report that the African world view and culture influenced the Report’s notion of corporate governance will also be critically reviewed. Finally it will be attempted to evaluate to what extent the recommendations of the King II Report live up to its own philosophical premises.

  12. A model based method for obtaining the open/closed field line boundary from the cusp auroral 6300 Å[OI] red line

    Science.gov (United States)

    Johnsen, M. G.; Lorentzen, D. A.; Holmes, J. M.; Løvhaug, U. P.

    2012-03-01

    Ground based optical instruments are invaluable tools for studies of processes associated with the cusps and auroral morphology. In this work we present a method for obtaining the magnetic latitude of the open/closed field line boundary (OCB) from the cusp 6300 Å[OI] auroral red line using a meridian scanning photometer. The method which is based on a pre-defined reference cusp aurora produced by the GLOW model is examined with respect to uncertainties, and we describe how a set of equations describing the error is constructed. The method is applicable to data from optical instruments located at high latitude observation sites such as Svalbard and Antarctica. Equations describing both errors and the mapping altitude for transforming the OCB from instrument centered coordinates to magnetic latitude for instrumentation located in Svalbard (Longyearbyen) are presented. Further, by applying the GLOW model we present results illustrating the great variability in the altitude profile of the atomic oxygen 6300 Å[OI] red line emission in the cusp. A simple calculation showing how a poleward neutral wind will change the latitudinal shape of the cusp aurora is also performed.

  13. Red, far red wavelength, the ratio red to far red, temperature and ...

    African Journals Online (AJOL)

    Measurements of temperature, red, far red wavelength of light and the ratio red to far red were made at every 10 minutes interval at marked points along a 15 m transect using thermometers and a Skye 660/730 Radiation Detector and Measuring unit (SKR100: SKR110) at Umudike, Nigeria. Readings were made during the ...

  14. Synchronization and an application of a novel fractional order King Cobra chaotic system

    Energy Technology Data Exchange (ETDEWEB)

    Muthukumar, P., E-mail: muthukumardgl@gmail.com; Balasubramaniam, P., E-mail: balugru@gmail.com [Department of Mathematics, Gandhigram Rural Institute‐Deemed University, Gandhigram 624 302, Tamilnadu (India); Ratnavelu, K., E-mail: kuru052001@gmail.com [Faculty of Science, Institute of Mathematical Sciences, University of Malaya, 50603 Kuala Lumpur (Malaysia)

    2014-09-01

    In this paper, we design a new three dimensional King Cobra face shaped fractional order chaotic system. The multi-scale synchronization scheme of two fractional order chaotic systems is described. The necessary conditions for the multi-scale synchronization of two identical fractional order King Cobra chaotic systems are derived through feedback control. A new cryptosystem is proposed for an image encryption and decryption by using synchronized fractional order King Cobra chaotic systems with the supports of multiple cryptographic assumptions. The security of the proposed cryptosystem is analyzed by the well known algebraic attacks. Numerical simulations are given to show the effectiveness of the proposed theoretical results.

  15. No barrier to emergence of bathyal king crabs on the Antarctic shelf

    DEFF Research Database (Denmark)

    Aronson, Richard B.; Smith, Kathryn E.; Vos, Stephanie C.

    2015-01-01

    showed that abundant, predatory king crabs comprise a reproductively viable population at 841- to 2,266-m depth. Depth profiles of temperature, salinity, habitat structure, food availability, and predators indicate that there are no barriers to prevent king crabs from moving upward onto the outer shelf...... at 400–550 m. A cold-water barrier above 200 m could be breached within the next few decades. Emergence of king crabs on the shelf could have catastrophic consequences for the unique seafloor communities of Antarctica....

  16. The perception of corporate services directorate in a metropolitan municipality on King III good governance compliance in business and projects

    Directory of Open Access Journals (Sweden)

    Sly Newton Mutiro

    2015-03-01

    Full Text Available Good governance has been and is a growing phenomenon for many business organisations regardless of size, profit margins and purpose for existence. The South African Metropolitan municipality Metropolitan Municipality is one such organisation that has adopted good governance models to business practices. The challenge was how to effectively and efficiently implement governance issues around projects and business organisations. A number of people, committees and institutions have developed different governance frameworks that can be adopted by organisations as a guide to good governance. This research is based on King III guide to good governance. The objective was to establish the perceptions of the corporate services directorate in the South African Metropolitan municipality municipality on King III good governance compliance by interviewing some employees orally and through a questionnaire. The responses were captured and analysed using IMB SPSS software. Problems were identified in governance training and understanding in general. Another major finding was poor communication internally and externally. To overcome these shortfall recommendations were made. Communication models, communication plan, governance models and training were recommended. The major challenges facing the South African Metropolitan municipality Metropolitan Municipality are poor effective governance communication and lack of governance training.

  17. Kaempferol as Selective Human MAO-A Inhibitor: Analytical Detection in Calabrian Red Wines, Biological and Molecular Modeling Studies.

    Science.gov (United States)

    Gidaro, Maria Concetta; Astorino, Christian; Petzer, Anél; Carradori, Simone; Alcaro, Francesca; Costa, Giosuè; Artese, Anna; Rafele, Giancarlo; Russo, Francesco M; Petzer, Jacobus P; Alcaro, Stefano

    2016-02-17

    The purpose of this work was to determine the kaempferol content in three red wines of Calabria, a southern Italian region with a great number of certified food products. Considering that wine cultivar, climate, and soil influence the qualitative and quantitative composition in flavonoids of Vitis vinifera L. berries, the three analyzed samples were taken from the 2013 vintage. Moreover, the Gaglioppo samples, with assigned Controlled Origin Denomination (DOC), were also investigated in the production of years 2008, 2010, and 2011. In addition to the analysis of kaempferol, which is present in higher concentration than in other Italian wines, in vitro assays were performed to evaluate, for the first time, the inhibition of the human monoamine oxidases (hMAO-A and hMAO-B). Molecular recognition studies were also carried out to provide insight into the binding mode of kaempferol and selectivity of inhibition of the hMAO-A isoform.

  18. KINETIC MODELING AND ISOTHERM STUDIES ON A BATCH REMOVAL OF ACID RED 114 BY AN ACTIVATED PLANT BIOMASS

    Directory of Open Access Journals (Sweden)

    N. RAJAMOHAN

    2013-12-01

    Full Text Available In this paper, the dye Acid Red 114(AR 114 was removed from aqueous solutions using Acid-Activated Eichornia Crassipes (AAEC under batch conditions. The optimum conditions for AR 114 removal were found to be pH 1.5, adsorbent dosage = 1.25 g/L of solution and equilibrium time = 3 h. The equilibrium data were evaluated for compliance with Langmuir, Freundlich and Temkin isotherms and Langmuir isotherm was found to fit well. The maximum sorption capacity was estimated as 112.34 mg/g of adsorbent. Also, adsorption kinetics of the dye was studied and the rates of sorption were found to follow pseudo-second order kinetics with good correlation (R2 ≥ 0.997.The kinetic study at different temperatures revealed that the sorption was an endothermic process. The activation energy of the sorption process was estimated as 9.722 kJ/mol.

  19. EPR studies of a red wine bottle deposit, and the precipitates from a 'model' wine , and a white wine, both artificially aged

    International Nuclear Information System (INIS)

    Mitri, M.

    2003-01-01

    Full text: A red wine waxy bottle deposit is known to be an anthocyanin-protein compound. The EPR signal shows the presence of a free radical signal, and a Cu(2+) signal with N superhyperfme structure. Subsequently, EPR study of a model wine, catechin being the only phenol, showed a Cu(2+) signal and a free radical signal. The precipitate thrown by the model wine after artificial aging for 3 months at 45C showed a Cu(2+) signal of different bonding, and a free radical signal. All the previously mentioned Cu(2+) signals showed (differing) hyperfine structures. The precipitate thrown by a similarly artificially aged Chardonnay showed a free radical signal, and a Cu(2+) signal without hyperfine structure: no Cu(2+) signal was detected in the mother liquor. The Cu(2+) bonding in each case will be discussed

  20. Radiological Risk Assessment for King County Wastewater Treatment Division

    Energy Technology Data Exchange (ETDEWEB)

    Strom, Daniel J.

    2005-08-05

    Staff of the King County Wastewater Treatment Division (WTD) have concern about the aftermath of a radiological dispersion event (RDE) leading to the introduction of significant quantities of radioactive material into the combined sanitary and storm sewer system in King County, Washington. Radioactive material could come from the use of a radiological dispersion device (RDD). RDDs include "dirty bombs" that are not nuclear detonations but are explosives designed to spread radioactive material (National Council on Radiation Protection and Measurements (NCRP) 2001). Radioactive material also could come from deliberate introduction or dispersion of radioactive material into the environment, including waterways and water supply systems. This document develops plausible and/or likely scenarios, including the identification of likely radioactive materials and quantities of those radioactive materials to be involved. These include 60Co, 90Sr, 137Cs, 192Ir, 226Ra, plutonium, and 241Am. Two broad categories of scenarios are considered. The first category includes events that may be suspected from the outset, such as an explosion of a "dirty bomb" in downtown Seattle. The explosion would most likely be heard, but the type of explosion (e.g., sewer methane gas or RDD) may not be immediately known. Emergency first responders must be able to quickly detect the radioisotopes previously listed, assess the situation, and deploy a response to contain and mitigate (if possible) detrimental effects resulting from the incident. In such scenarios, advance notice of about an hour or two might be available before any contaminated wastewater reaches a treatment plant. The second category includes events that could go initially undetected by emergency personnel. Examples of such a scenario would be the inadvertent or surreptitious introduction of radioactive material into the sewer system. Intact rogue radioactive sources from industrial radiography devices, well-logging apparatus, or

  1. Calibration, verification, and use of a water-quality model to simulate effects of discharging treated wastewater to the Red River of the North at Fargo, North Dakota

    Science.gov (United States)

    Wesolowski, E.A.

    1994-01-01

    A 30.8-mile reach of the Red River of the North receives treated wastewater from plants at Fargo, North Dakota, and Moorhead, Minnesota, and streamflows from the Sheyenne River. A one-dimensional, steady-state, stream water-quality model, the Enhanced Stream Water Quality Model (QUAL2E), was calibrated and verified for summer stream flow conditions to simulate some of the biochemical processes that result from discharging treated wastewater into this reach of the river. Data obtained to define the river's transport conditions are measurements of channel geometry, streamflow, traveltime, specific conductance, and temperature. Data obtained to define the river's water-quality conditions are measurements of concentrations of selected water-quality constituents and estimates of various reaction coefficients. Most of the water-quality data used to calibrate and verify the model were obtained during two synoptic samplings in August 1989 and August 1990. The water-quality model simulates specific conductance, water temperature, dissolved oxygen, ultimate carbonaceous biochemical oxygen demand, total nitrite plus nitrate as nitrogen, total ammonia as nitrogen, total organic nitrogen as nitrogen, total phosphorus as phosphorus, and algal biomass as chlorophyll a. Of the nine properties and constituents that the calibrated model simulates, all except algae were verified. When increases in dissolved-oxygen concentration are considered, model sensitivity analyses indicate that dissolved-oxygen concentration is most sensitive to maximum specific algal growth rate. When decreases in dissolved-oxygen concentration are considered, model sensitivity analyses indicate that dissolved-oxygen concentration is most sensitive to point-source ammonia. Model simulations indicate nitrification and sediment oxygen demand consume most of the dissolved oxygen in the study reach. The Red River at Fargo Water-Quality Model and the verification data set, including associated reaction

  2. Maya Angelou to visit Virginia Tech during third annual Martin Luther King, Jr. celebration

    OpenAIRE

    Williams, Meghan

    2007-01-01

    A remarkable woman who is hailed as one of the greatest voices of contemporary literature, Maya Angelou, will be a guest speaker during the third annual Dr. Martin Luther King Jr. celebration at Virginia Tech.

  3. Maya Angelou to speak during Virginia Tech's third annual Martin Luther King Jr. celebration

    OpenAIRE

    Williams, Meghan

    2008-01-01

    A remarkable woman who is hailed as one of the greatest voices of contemporary literature, Maya Angelou, will be a guest speaker during the third annual Dr. Martin Luther King Jr. celebration at Virginia Tech.

  4. GPM GROUND VALIDATION DUAL POLARIZED C-BAND DOPPLER RADAR KING CITY GCPEX V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The GPM Ground Validation Dual Polarized C-Band Doppler Radar King City GCPEx dataset has special Range Height Indicator (RHI) and sector scans of several dual...

  5. The Ride of the Kings in Vlčnov from the Perspective of Contemporary Research

    Czech Academy of Sciences Publication Activity Database

    Stavělová, Daniela

    2015-01-01

    Roč. 25, č. 5 (2015), s. 47-64 ISSN 0862-8351 Institutional support: RVO:68378076 Keywords : Ride of the Kings * field research * methodology * festival * traditional custom * Vlčnov Subject RIV: AC - Archeology, Anthropology, Ethnology

  6. Micro-gravity studies in archeo-prospecting of the Valley of the Kings, Luxor, Egypt

    Czech Academy of Sciences Publication Activity Database

    Issawy, E. A.; Tealeb, A. A.; Mrlina, Jan; Radwan, A. H.; Hassan, G. S.; Sakr, K. O.

    - (2001), s. 201-212 ISSN 1110-6417 Institutional research plan: CEZ:AV0Z3012916 Keywords : micro-gravity investigations * archaeo-prospecting * Valley of the Kings * Egypt Subject RIV: DE - Earth Magnetism, Geodesy, Geography

  7. Red Grape Skin Polyphenols Blunt Matrix Metalloproteinase-2 and -9 Activity and Expression in Cell Models of Vascular Inflammation: Protective Role in Degenerative and Inflammatory Diseases.

    Science.gov (United States)

    Calabriso, Nadia; Massaro, Marika; Scoditti, Egeria; Pellegrino, Mariangela; Ingrosso, Ilaria; Giovinazzo, Giovanna; Carluccio, Maria Annunziata

    2016-08-29

    Matrix metalloproteinases (MMPs) are endopeptidases responsible for the hydrolysis of various components of extracellular matrix. MMPs, namely gelatinases MMP-2 and MMP-9, contribute to the progression of chronic and degenerative diseases. Since gelatinases' activity and expression are regulated by oxidative stress, we sought to evaluate whether supplementation with polyphenol-rich red grape skin extracts modulated the matrix-degrading capacity in cell models of vascular inflammation. Human endothelial and monocytic cells were incubated with increasing concentrations (0.5-25 μg/mL) of Negroamaro and Primitivo red grape skin polyphenolic extracts (NSPE and PSPE, respectively) or their specific components (0.5-25 μmol/L), before stimulation with inflammatory challenge. NSPE and PSPE inhibited, in a concentration-dependent manner, endothelial invasion as well as the MMP-9 and MMP-2 release in stimulated endothelial cells, and MMP-9 production in inflamed monocytes, without affecting tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2. The matrix degrading inhibitory capacity was the same for both NSPE and PSPE, despite their different polyphenolic profiles. Among the main polyphenols of grape skin extracts, trans-resveratrol, trans-piceid, kaempferol and quercetin exhibited the most significant inhibitory effects on matrix-degrading enzyme activities. Our findings appreciate the grape skins as rich source of polyphenols able to prevent the dysregulation of vascular remodelling affecting degenerative and inflammatory diseases.

  8. Coupled heat and fluid flow modeling of the Carboniferous Kuna Basin, Alaska: Implications for the genesis of the Red Dog Pb-Zn-Ag-Ba ore district

    Science.gov (United States)

    Garven, G.; Raffensperger, Jeff P.; Dumoulin, J.A.; Bradley, D.A.; Young, L.E.; Kelley, K.D.; Leach, D.L.

    2003-01-01

    The Red Dog deposit is a giant 175 Mton (16% Zn, 5% Pb), shale-hosted Pb-Zn-Ag-Ba ore district situated in the Carboniferous Kuna Basin, Western Brooks Range, Alaska. These SEDEX-type ores are thought to have formed in calcareous turbidites and black mudstone at elevated sub-seafloor temperatures (120-150??C) within a hydrogeologic framework of submarine convection that was structurally organized by large normal faults. The theory for modeling brine migration and heat transport in the Kuna Basin is discussed with application to evaluating flow patterns and heat transport in faulted rift basins and the effects of buoyancy-driven free convection on reactive flow and ore genesis. Finite element simulations show that hydrothermal fluid was discharged into the Red Dog subbasin during a period of basin-wide crustal heat flow of 150-160 mW/m2. Basinal brines circulated to depths as great as 1-3 km along multiple normal faults flowed laterally through thick clastic aquifers acquiring metals and heat, and then rapidly ascended a single discharge fault zone at rates ??? 5 m/year to mix with seafloor sulfur and precipitate massive sulfide ores. ?? 2003 Elsevier Science B.V. All rights reserved.

  9. AFSC/RACE/SAP/Long: Data from: A novel quantitative model of multiple discrete stage transitions applied to crustacean larval development

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set describes the holding temperatures and developmental stages of larvae of red and blue king crab (Paralithodes camtschaticus and P. platypus) reared to...

  10. Lee de Forest King of Radio, Television, and Film

    CERN Document Server

    Adams, Mike

    2012-01-01

    Lee de Forest, Yale doctorate and Oscar winner, gave voice to the radio and the motion picture. Yet by the 1930s, after the radio and the Talkies were regular features of American life, Lee de Forest had seemingly lost everything. Why? Why didn’t he receive the recognition and acclaim he sought his entire life until years later in 1959, when he was awarded an Oscar? A lifelong innovator, Lee de Forest invented the three-element vacuum tube which he developed between 1906 and 1916 as a detector, amplifier, and oscillator of radio waves. As early as 1907, he was broadcasting music programming. In 1918, he began to develop a system for recording and playing back sound by using light patterns on motion picture film. In order to promote and demonstrate his process he made hundreds of short sound films, found theatres for their showing, and issued publicity to gain audiences for his invention. While he received many patents for this technology, he was ignored by the film industry. Lee de Forest, King of Radio, Te...

  11. The Mystical Paradigm in Shakespeare’s King Lear

    Directory of Open Access Journals (Sweden)

    A. M. Potter

    1993-03-01

    Full Text Available This article takes as its starting point the statement by Caroline Spurgeon that mysticism, with its aim of the union with the One, does not appear in Shakespeare's works. It is initially pointed out that any suggestion that mysticism is present in any work is fraught with serious reception problems, since mysticism is very adversely viewed at present, even by supposedly open-minded literary critics. After providing a definition of mysticism in terms which attempt to alleviate these reception problems, evidence will then be presented from King Lear to suggest that the play is built on the basis of an affirmation of unity, and a perception of disunity as resulting from the destructive effects of difference, division and duality. This, it is suggested, implies that Shakespeare was thinking in terms of the mystical paradigm when he wrote the play. In conclusion, some indication is given of possible significances of the presence of the mystical paradigm in the play, and how richly suggestive the presence of such a paradigm is in a play such as this.

  12. Phytochemical Studies and Antioxidant Activities of Artocarpus scortechinii King

    Directory of Open Access Journals (Sweden)

    Norzafneza Mohd Arriffin

    2017-05-01

    Full Text Available Six known compounds identified as 4',5-dihydroxy-6,7-(2,2-dimethylpyrano-2'-methoxy-8-γ,γ-dimethylallyflavone (1, cudraflavone A (2, artocarpin(3, cycloartobiloxanthone (4, artonin E (5 and oxyresveratrol (6 were isolated from the stem barks of Artocapus scortechinii King. Another four compounds namely macakurzin C (7, flemichapparin A (8, luteolin (9 and apigenin (10 were isolated from the leaves. Structures of all pure compounds were elucidated spectroscopically using 1D NMR ( 1H, 13C, DEPT, 2D NMR (COSY, HMQC, HMBC, MS and FTIR, as well as by comparison with literature data. All isolated compounds were evaluated for their antioxidant capacities using 2,2-diphenyl-1-picrylhydrazyl (DPPH, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid (ABTS and ferric reducing antioxidant potential (FRAP assays. Luteolin (9 showed the best ability to act as DPPH free radical scavenger with IC 50 value of 9.51 µM. Luteolin (9 also exhibited the strongest scavenger and potent ferric ion reducer compared to other isolated compounds in the ABTS and FRAP assays with IC 50 value of 124.4µM and 4.07 ± 0.180 mM FRAP equivalent respectively.

  13. Magnetometry at Uruk (Iraq): The city of King Gilgamesh

    Science.gov (United States)

    Fassbinder, J.; Becker, H.; van Ess, M.

    2003-04-01

    Uruk (Tell Warka) is one of the most famous sites for the early cultural development at Mesopotamia. The Sumerian city state was also important for the origin of writing and Uruk was the scene of action of mans oldest epic, the famous Epic of Gilgamesh (2600 B.C). During the time of the Sassanides, 400 A.D. the city was given up completely. Today the ruin is dominated by shallow hills and wadis, covered by pottery, mudbricks and slags. The area is totally free of modern buildings and far away from the modern village of Warka. Therefore it is an ideal place for uncompensated cesium magnetometry. The most sensational find was the discovery of a canal system inside the city. Furthermore the magnetogram shows the remains of buildings of the Babylonian type as well as garden structures, a middle Babylonian graveyard and the so called "New Years Temple" of the God Anu or Godess Ischtar. The city wall, which we prospected in a length of more than one kilometer, includes a water gate and is nearly 40 meters broad. From magnetometry it is evident that it was build by burned mudbricks as it was described by the Epic. In the west of the "New Years Temple" in the middle of the former Euphrates river we detected the remains of a building which may be interpreted as a burial. But if this building is the grave of the famous King Gilgamesh as it was described by the Epic of Gilgamesh it must remain speculative.

  14. Color ornaments and territory position in king penguins.

    Science.gov (United States)

    Keddar, Ismaël; Jouventin, Pierre; Dobson, F Stephen

    2015-10-01

    King penguins exhibit mutual color ornamentation of feathers and beak color. They breed in dense colonies and produce a single chick every 2 years. Thus, males and females must choose partners carefully to be reproductively successful, and auricular patches of males and UV coloration of beak spots have been shown to influence mate choice. Position in the breeding colony is also important to reproductive success, with pairs on the edge of the colony less successful than those in the center. We studied the mutual ornaments, individual condition, and position of pairs in their breeding colony. Males were significantly larger than females in size, body mass, and auricular patch size. Within pairs, auricular patch size of males and females were significantly correlated, and male auricular patch size and body mass were significantly associated, suggesting a link between this ornament and male body condition. Moving from the edge to the center of the colony, pairs had larger yellow-orange auricular patches, indicating a link between this ornament and settlement in higher quality territories in the center of the colony. Pairs were also less brightly brown colored on the breast and less saturated in UV color of the beak spot. Since we observed pairs that were settling for egg laying, location in the colony may have reflected aspects of pair condition, rather than later jockeying for positioning using ornaments as signals of behavioral dominance. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Acanthamoeba Keratitis at the King Khaled Eye Specialist Hospital

    International Nuclear Information System (INIS)

    Al-Mezaine, H.; Al-Muteb, M.; Al-Motowa, S.; Wagoner, M. D.

    2005-01-01

    To quantify the number of cases and clinical courses of Acanthamoeba keratitis treated at the King Khaled Eye Specialist Hospital (KKESH) between December 1982 and May 2005, and to review their clinical course and response to medical and surgical therapy. Retrospective review of medical records of all patients with Acanthamoeba keratitis diagnosed by the KKESH Microbiology or Pathology or Pathology Laboratory since the opening of the hospital. During a period of over 22 years, only six cases of confirmed. Acanthamoeba keratitis were diagnosedand treated at KKESH. In two cases the diagnosis was made by corneal biopsy, while four cases required examination of a histopathology specimen obtained at the time of therapeutic keratoplasty to establish the diagnosis. One eye was cured by medical therapy, while five eyes required one (4eyes) or two (1 eye) therapeutic penetrating keratoplasty (PKP) to achieve a clinical cure. Three eyes achieved good visual acuity (20/40, 20/50, 20/60), one eye achieved fair visual acuity (20/160), and two eyes suffered profound visual loss (hand motions). The incidence of Acanthamoeba keratitis may be less in Saudi Arabia than reported in Western countries although the clinical is similarly complicated, with most cases requiring therapeutic keratoplasty for definitive education of the organism. (author)

  16. Studies of free breathing three-dimensional heart delayed enhancement MRI under resting respiration using KING

    International Nuclear Information System (INIS)

    Ishihara, Masaru; Kishimoto, Kinya; Ishimoto, Takeshi; Wake, Seiji

    2007-01-01

    Heart delayed enhancement magnetic resonance imaging (MRI) is an attempt to obtain intense image contrast using the null-point of normal myocardium, which changes with time. Imaging is generally conducted under breath-hold, but, if the retrospective gating method is used, it is necessary to shorten the imaging time and to fill the center of the k-space with the data in the early phase of imaging. In the present study, we examined free breathing three-dimensional heart delayed enhancement MRI (3D/KING method) using k-space inspired navigator gating (KING). In the 3D/KING, since respiratory artifact decreases by combining with the fat suppression technique and the gating window can be set widely, the imaging time was shortened in comparison with the conventional 3D method. In 3D/KING/isotropic (iso), on the other hand, the respiratory artifact was decreased by transverse imaging. The mean end time of imaging by the 3D/KING method (n=10) and the 3D/KING/iso (n=5) was 3.05±0.69 and 4.59±0.74 minutes, respectively. Moreover, the signal intensity ratio (SIR) of abnormal myocardium versus normal myocardium in the 3D/KING method was low in comparison with that in the breath-hold method. However, the capability to detect lesions was similar, and good images were obtained from the patients showing poor breath-hold. In the 3D/KING/iso, heart delayed enhancement MRI from multiple directions could be conducted in a single imaging by using the image reconstitution method. (author)

  17. About the Political Dimensions of the Formation of the King James Bible

    OpenAIRE

    Rather, Michael G., Jr.

    2009-01-01

    Michael G. Rather Jr., examines in his article "About the Political Dimensions of the Formation of the King James Bible" the politics surrounding the formation of one of the most influential text in culture and politics in England and later in English-speaking countries. The translators and King exhibited a duality of beliefs emblematic of Jacobean society. These dualities of hierarchy and commonness, ceremony and purity, clarity and majesty were instituted in England followed by the Australi...

  18. Lidar-revised geologic map of the Des Moines 7.5' quadrangle, King County, Washington

    Science.gov (United States)

    Tabor, Rowland W.; Booth, Derek B.

    2017-11-06

    This map is an interpretation of a modern lidar digital elevation model combined with the geology depicted on the Geologic Map of the Des Moines 7.5' Quadrangle, King County, Washington (Booth and Waldron, 2004). Booth and Waldron described, interpreted, and located the geology on the 1:24,000-scale topographic map of the Des Moines 7.5' quadrangle. The base map that they used was originally compiled in 1943 and revised using 1990 aerial photographs; it has 25-ft contours, nominal horizontal resolution of about 40 ft (12 m), and nominal mean vertical accuracy of about 10 ft (3 m). Similar to many geologic maps, much of the geology in the Booth and Waldron (2004) map was interpreted from landforms portrayed on the topographic map. In 2001, the Puget Sound Lidar Consortium obtained a lidar-derived digital elevation model (DEM) for much of the Puget Sound area, including the entire Des Moines 7.5' quadrangle. This new DEM has a horizontal resolution of about 6 ft (2 m) and a mean vertical accuracy of about 1 ft (0.3 m). The greater resolution and accuracy of the lidar DEM compared to topography constructed from air-photo stereo models have much improved the interpretation of geology, even in this heavily developed area, especially the distribution and relative age of some surficial deposits. For a brief description of the light detection and ranging (lidar) remote sensing method and this data acquisition program, see Haugerud and others (2003). 

  19. King-Denborough Syndrome: report of two Brazilian cases Síndrome de King-Denborough: relato de dois casos

    Directory of Open Access Journals (Sweden)

    Umbertina Conti Reed

    2002-09-01

    Full Text Available We report on two boys aged 2 and 6 years-old respectively with dysmorphic face, ptosis, down-slanting palpebral fissures, hypertelorism, epicanthic folds, low-set ears, malar hypoplasia, micrognathia, high-arched palate, clinodactyly, palmar simian line, pectus excavatum, winging of the scapulae, lumbar lordosis and mild thoracic scoliosis who present congenital hypotonia, slightly delayed motor development, diffuse joint hyperextensibility and mild proximal weakness. The muscle biopsy revealed minimal but identifiable changes represented by size fiber variability, type I fiber predominance and atrophy, perimysial fibrous infiltration and some disarray of the intermyofibrillary network. These cases correspond to the first Brazilian reports of the King-Denborough syndrome and our objective is increasing the awareness of this disorder as these patients are predisposed to developing malignant hyperthermia.Relatamos dois meninos de 2 e 6 anos de idade que apresentam aspectos dismórficos caracterizados por facies alongada, ptose e fenda palpebral anti-mongólica, hipertelorismo, epicanto bilateral, orelhas de implantação baixa, hipoplasia malar, micrognatia, pálato ogival, clinodactilia, prega palmar única, "pectus excavatum", escápulas aladas, lordose lombar e escoliose torácica. Apresentam hipotonia congênita, hiperextensibilidade articular, fraqueza muscular e retardo do desenvolvimento motor. A biópsia muscular revelou em ambos alterações mínimas: variabilidade do tamanho das fibras, predomínio e atrofia de fibras tipo I, discreta infiltração perimisial e desarranjo intermiofibrilar. Os aspectos dismórficos associados à miopatia congênita configuram a síndrome de King-Denborough, da qual acreditamos serem estes os primeiros casos descritos no Brasil. Como a síndrome se acompanha de alto risco de desenvolver hipertermia maligna na indução anestésica, o objetivo deste relato é chamar a atenção para a necessidade do diagn

  20. Applying the Halo Model to Large Scale Structure Measurements of the Luminous Red Galaxies: SDSS DR7 Preliminary Results

    International Nuclear Information System (INIS)

    Reid, Beth A.

    2009-01-01

    The non-trivial relationship between observations of galaxy positions in redshift space and the underlying matter field complicates our ability to determine the linear theory power spectrum and extract cosmological information from galaxy surveys. The Sloan Digital Sky Survey (SDSS) Luminous Red Galaxy (LRG) catalog has the potential to place powerful constraints on cosmological parameters. LRGs are bright, highly biased tracers of large-scale structure. However, because they are highly biased, the non-linear contribution of satellite galaxies to the galaxy power spectrum is large and Fingers-of-God are significant. We propose an new approach to recovering the matter field from galaxy observations. Our approach is to use halos rather than galaxies to trace the underlying mass distribution. We identify Fingers-of-God (FOGs) and replace each FOG with a single halo object. This removes the nonlinear contribution of satellite galaxies, the one-halo term. We test our method on a large set of high-fidelity mock SDSS LRG catalogs and present consistency checks between the mock and LRG DR7 reconstructed halo density fields. We present preliminary cosmological constraints from the LRG DR7 reconstructed halo density field power spectrum. Finally, we summarize the potential gains in cosmological parameter constraints using our approach and the largest remaining sources of systematic errors.

  1. Physical and chemical properties of deposited airborne particulates over the Arabian Red Sea coastal plain

    KAUST Repository

    Engelbrecht, Johann

    2017-09-27

    Mineral dust is the most abundant aerosol, having a profound impact on the global energy budget. This research continues our previous studies performed on surface soils in the Arabian Peninsula, focusing on the mineralogical, physical and chemical composition of dust deposits from the atmosphere at the Arabian Red Sea coast. For this purpose, aerosols deposited from the atmosphere are collected during 2015 at six sites on the campus of the King Abdullah University of Science and Technology (KAUST) situated on the Red Sea coastal plain of Saudi Arabia and subjected to the same chemical and mineralogical analysis we conducted on soil samples. Frisbee deposition samplers with foam inserts were used to collect dust and other deposits, for the period December 2014 to December 2015. The average deposition rate measured at KAUST for this period was 14 g m−2 per month, with lowest values in winter and increased deposition rates in August to October. The particle size distributions provide assessments of  < 10 and  < 2.5 µm dust deposition rates, and it is suggested that these represent proxies for PM10 (coarse) and PM2. 5 (fine) particle size fractions in the dust deposits. X-ray diffraction (XRD) analysis of a subset of samples confirms variable amounts of quartz, feldspars, micas, and halite, with lesser amounts of gypsum, calcite, dolomite, hematite, and amphibole. Freeze-dried samples were re-suspended onto the Teflon® filters for elemental analysis by X-ray fluorescence (XRF), while splits from each sample were analyzed for water-soluble cations and anions by ion chromatography. The dust deposits along the Red Sea coast are considered to be a mixture of dust emissions from local soils and soils imported from distal dust sources. Airborne mineral concentrations are greatest at or close to dust sources, compared to those through medium- and long-range transport. It is not possible to identify the exact origin of deposition samples from the

  2. Physical and chemical properties of deposited airborne particulates over the Arabian Red Sea coastal plain

    Science.gov (United States)

    Engelbrecht, Johann P.; Stenchikov, Georgiy; Jish Prakash, P.; Lersch, Traci; Anisimov, Anatolii; Shevchenko, Illia

    2017-09-01

    Mineral dust is the most abundant aerosol, having a profound impact on the global energy budget. This research continues our previous studies performed on surface soils in the Arabian Peninsula, focusing on the mineralogical, physical and chemical composition of dust deposits from the atmosphere at the Arabian Red Sea coast. For this purpose, aerosols deposited from the atmosphere are collected during 2015 at six sites on the campus of the King Abdullah University of Science and Technology (KAUST) situated on the Red Sea coastal plain of Saudi Arabia and subjected to the same chemical and mineralogical analysis we conducted on soil samples. Frisbee deposition samplers with foam inserts were used to collect dust and other deposits, for the period December 2014 to December 2015. The average deposition rate measured at KAUST for this period was 14 g m-2 per month, with lowest values in winter and increased deposition rates in August to October. The particle size distributions provide assessments of analysis of a subset of samples confirms variable amounts of quartz, feldspars, micas, and halite, with lesser amounts of gypsum, calcite, dolomite, hematite, and amphibole. Freeze-dried samples were re-suspended onto the Teflon® filters for elemental analysis by X-ray fluorescence (XRF), while splits from each sample were analyzed for water-soluble cations and anions by ion chromatography. The dust deposits along the Red Sea coast are considered to be a mixture of dust emissions from local soils and soils imported from distal dust sources. Airborne mineral concentrations are greatest at or close to dust sources, compared to those through medium- and long-range transport. It is not possible to identify the exact origin of deposition samples from the mineralogical and chemical results alone. These aerosol data are the first of their kind from the Red Sea region. They will help assess their potential nutrient input into the Red Sea, as well the impact on human health

  3. Two-dimensional strain-hardening membrane model for large deformation behavior of multiple red blood cells in high shear conditions.

    Science.gov (United States)

    Ye, Swe Soe; Ng, Yan Cheng; Tan, Justin; Leo, Hwa Liang; Kim, Sangho

    2014-05-13

    Computational modeling of Red Blood Cell (RBC) flow contributes to the fundamental understanding of microhemodynamics and microcirculation. In order to construct theoretical RBC models, experimental studies on single RBC mechanics have presented a material description for RBC membranes based on their membrane shear, bending and area moduli. These properties have been directly employed in 3D continuum models of RBCs but practical flow analysis with 3D models have been limited by their computationally expensive nature. As such, various researchers have employed 2D models to efficiently and qualitatively study microvessel flows. Currently, the representation of RBC dynamics using 2D models is a limited methodology that breaks down at high shear rates due to excessive and unrealistic stretching. We propose a localized scaling of the 2D elastic moduli such that it increases with RBC local membrane strain, thereby accounting for effects such as the Poisson effect and membrane local area incompressibility lost in the 2D simplification. Validation of our 2D Large Deformation (2D-LD) RBC model was achieved by comparing the predicted RBC deformation against the 3D model from literature for the case of a single RBC in simple shear flow under various shear rates (dimensionless shear rate G = 0.05, 0.1, 0.2, 0.5). The multi-cell flow of RBCs (38% Hematocrit) in a 20 μm width microchannel under varying shear rates (50, 150, 150 s-1) was then simulated with our proposed model and the popularly-employed 2D neo-Hookean model in order to evaluate the efficacy of our proposed 2D-LD model. The validation set indicated similar RBC deformation for both the 2D-LD and the 3D models across the studied shear rates, highlighting the robustness of our model. The multi-cell simulation indicated that the 2D neo-Hookean model predicts noodle-like RBC shapes at high shear rates (G = 0.5) whereas our 2D-LD model maintains sensible RBC deformations. The ability of the 2D-LD model to

  4. Predicting dynamics and rheology of blood flow: A comparative study of multiscale and low-dimensional models of red blood cells

    Science.gov (United States)

    Pan, Wenxiao; Fedosov, Dmitry A.; Caswell, Bruce; Karniadakis, George Em

    2011-01-01

    We compare the predictive capability of two mathematical models for red blood cells (RBCs) focusing on blood flow in capillaries and arterioles. Both RBC models as well as their corresponding blood flows are based on the dissipative particle dynamics (DPD) method, a coarse-grained molecular dynamics approach. The first model employs a multiscale description of the RBC (MS-RBC), with its membrane represented by hundreds or even thousands of DPD-particles connected by springs into a triangular network in combination with out-of-plane elastic bending resistance. Extra dissipation within the network accounts for membrane viscosity, while the characteristic biconcave RBC shape is achieved by imposition of constraints for constant membrane area and constant cell volume. The second model is based on a low-dimensional description (LD-RBC) constructed as a closed torus-like ring of only 10 large DPD colloidal particles. They are connected into a ring by worm-like chain (WLC) springs combined with bending resistance. The LD-RBC model can be fitted to represent the entire range of nonlinear elastic deformations as measured by optical-tweezers for healthy and for infected RBCs in malaria. MS-RBCs suspensions model the dynamics and rheology of blood flow accurately for any vessel size but this approach is computationally expensive for vessel diameters above 100 microns. Surprisingly, the much more economical suspensions of LD-RBCs also capture the blood flow dynamics and rheology accurately except for small-size vessels comparable to RBC diameter. In particular, the LD-RBC suspensions are shown to properly capture the experimental data for the apparent viscosity of blood and its cell-free layer (CFL) in tube flow. Taken together, these findings suggest a hierarchical approach in modeling blood flow in the arterial tree, whereby the MS-RBC model should be employed for capillaries and arterioles below 100 microns, the LD-RBC model for arterioles, and the continuum description for

  5. Integrating Global Satellite-Derived Data Products as a Pre-Analysis for Hydrological Modelling Studies: A Case Study for the Red River Basin

    Directory of Open Access Journals (Sweden)

    Gijs Simons

    2016-03-01

    Full Text Available With changes in weather patterns and intensifying anthropogenic water use, there is an increasing need for spatio-temporal information on water fluxes and stocks in river basins. The assortment of satellite-derived open-access information sources on rainfall (P and land use/land cover (LULC is currently being expanded with the application of actual evapotranspiration (ETact algorithms on the global scale. We demonstrate how global remotely sensed P and ETact datasets can be merged to examine hydrological processes such as storage changes and streamflow prior to applying a numerical simulation model. The study area is the Red River Basin in China in Vietnam, a generally challenging basin for remotely sensed information due to frequent cloud cover. Over this region, several satellite-based P and ETact products are compared, and performance is evaluated using rain gauge records and longer-term averaged streamflow. A method is presented for fusing multiple satellite-derived ETact estimates to generate an ensemble product that may be less susceptible, on a global basis, to errors in individual modeling approaches. Subsequently, monthly satellite-derived rainfall and ETact are combined to assess the water balance for individual subcatchments and types of land use, defined using a global land use classification improved based on auxiliary satellite data. It was found that a combination of TRMM rainfall and the ensemble ETact product is consistent with streamflow records in both space and time. It is concluded that monthly storage changes, multi-annual streamflow and water yield per LULC type in the Red River Basin can be successfully assessed based on currently available global satellite-derived products.

  6. Removal of 4-Ethylphenol and 4-Ethylguaiacol with Polyaniline-Based Compounds in Wine-Like Model Solutions and Red Wine

    Directory of Open Access Journals (Sweden)

    Verónica Carrasco-Sánchez

    2015-08-01

    Full Text Available Volatile phenols, such as 4-ethyphenol (4-EP and 4-ethylguaiacol (4-EG, are responsible for the “Brett character” found in wines contaminated with Brettanomyces yeast (i.e., barnyard, animal, spicy and smoky aromas. In these trials, we explore the effectiveness of polyaniline-based compounds (polyaniline emeraldin salt (PANI-ES and polyanaline emeraldin base (PANI-EB, for the removal of 4-EP and 4-EG from acidic model solutions and red wine. First, a screening study, performed in an acidified 12% ethanol solution, was used to optimize parameters such as contact time and the amount of polymers required to remove 4-EP and 4-EG. Then, the trapping ability of PANI agents towards 4-EP and 4-EG was evaluated in a model solution containing other wine phenolics that could potentially be trapped by PANI (i.e., gallic acid and 4-methylcatechol. The results of this trial showed that both PANI compounds were capable of removing 4-EP, 4-EG, regardless of the presence of other phenolic compounds present at a much higher concentration. Finally, the capturing ability of PANI was evaluated in a red wine sample containing 5 mg·L−1 of 4-EP, 5 mg·L−1 of 4-EG and 2.03 ± 0.02 g·L−1 of total phenolics. The results showed that PANI-EB removed significantly more 4-EP and 4-EG than PANI-ES. For instance, a treatment with 10 mg·mL−1 of PANI-EB produced a 67.8% reduction of 4-EP, 50% reduction of 4-EG and 41.38% decrease in total phenols.

  7. Removal of 4-Ethylphenol and 4-Ethylguaiacol with Polyaniline-Based Compounds in Wine-Like Model Solutions and Red Wine.

    Science.gov (United States)

    Carrasco-Sánchez, Verónica; John, Amalraj; Marican, Adolfo; Santos, Leonardo S; Laurie, V Felipe

    2015-08-05

    Volatile phenols, such as 4-ethyphenol (4-EP) and 4-ethylguaiacol (4-EG), are responsible for the "Brett character" found in wines contaminated with Brettanomyces yeast (i.e., barnyard, animal, spicy and smoky aromas). In these trials, we explore the effectiveness of polyaniline-based compounds (polyaniline emeraldin salt (PANI-ES) and polyanaline emeraldin base (PANI-EB)), for the removal of 4-EP and 4-EG from acidic model solutions and red wine. First, a screening study, performed in an acidified 12% ethanol solution, was used to optimize parameters such as contact time and the amount of polymers required to remove 4-EP and 4-EG. Then, the trapping ability of PANI agents towards 4-EP and 4-EG was evaluated in a model solution containing other wine phenolics that could potentially be trapped by PANI (i.e., gallic acid and 4-methylcatechol). The results of this trial showed that both PANI compounds were capable of removing 4-EP, 4-EG, regardless of the presence of other phenolic compounds present at a much higher concentration. Finally, the capturing ability of PANI was evaluated in a red wine sample containing 5 mg·L-1 of 4-EP, 5 mg·L-1 of 4-EG and 2.03 ± 0.02 g·L-1 of total phenolics. The results showed that PANI-EB removed significantly more 4-EP and 4-EG than PANI-ES. For instance, a treatment with 10 mg·mL-1 of PANI-EB produced a 67.8% reduction of 4-EP, 50% reduction of 4-EG and 41.38% decrease in total phenols.

  8. Solar Cycle Variation of Upper Thermospheric Temperature Over King Sejong Station, Antarctica

    Directory of Open Access Journals (Sweden)

    Jong-Kyun Chung

    2000-12-01

    Full Text Available A ground Fabry-Perot interferometer has been used to measure atomic oxygen nightglow (OI 630.0 nm from the thermosphere (about 250 km at King Sejong station (KSS, geographic: 62.22oS, 301.25oE; geomagnetic: 50.65oS, 7.51oE, Antarctica. While numerous studies of the thermosphere have been performed on high latitude using ground-based Fabry-Perot interferometers, the thermospheric measurements in the Southern Hemisphere are relatively new and sparse. Therefore, the nightglow measurements at KSS play an important role in extending the thermospheric studies to the Southern Hemisphere. In this study, we investigated the effects of the geomagnetic and solar activities on the thermospheric neutral temperatures that have been observed at KSS in 1989 and 1997. The measured average temperatures are 1400 K in 1989 and 800 K in 1997, reflecting the influence of the solar activity. The measurements were compared with empirical models, MSIS-86 and semi-empirical model, VSH.

  9. The return of the King: No-Scale F-SU(5

    Directory of Open Access Journals (Sweden)

    Tianjun Li

    2017-01-01

    Full Text Available We revisit the viable parameter space in No-Scale F-SU(5, examining the Grand Unified Theory within the context of the prevailing gluino mass limits established by the LHC. The satisfaction of both the No-Scale boundary condition and the experimentally measured Standard Model (SM like Higgs boson mass requires a lower limit on the gluino mass in the model space of about 1.9 TeV, which maybe not coincidentally is the current LHC supersymmetry search bound. This offers a plausible explanation as to why a supersymmetry signal has thus far not been observed at the LHC. On the contrary, since the vector-like flippon particles are relatively heavy due to the strict condition that the supersymmetry breaking soft term Bμ must vanish at the unification scale, we also cannot address the recently vanished 750 GeV diphoton resonance at the 13 TeV LHC. Therefore, No-Scale F-SU(5 returns as a King after the spurious 750 GeV diphoton excess was gone with the wind.

  10. Biofortified red mottled beans (phaseolus vulgaris L.) in a maize and bean diet provide more bioavailable iron than standard red mottled beans: studies in poultry (Gallus gallus) and an in vitro digestion/Caco-2 model

    Science.gov (United States)

    The objective was to compare the capacities of biofortified and standard colored beans to deliver iron (Fe) for hemoglobin synthesis. Two isolines of large-seeded, red mottled Andean beans (Phaseolus valgaris L.), one standard (“Low FE”) and the other biofortified (“High Fe”) in Fe (49 and 71 ug Fe...

  11. The red queen model of recombination hotspots evolution in the light of archaic and modern human genomes.

    Science.gov (United States)

    Lesecque, Yann; Glémin, Sylvain; Lartillot, Nicolas; Mouchiroud, Dominique; Duret, Laurent

    2014-11-01

    Recombination is an essential process in eukaryotes, which increases diversity by disrupting genetic linkage between loci and ensures the proper segregation of chromosomes during meiosis. In the human genome, recombination events are clustered in hotspots, whose location is determined by the PRDM9 protein. There is evidence that the location of hotspots evolves rapidly, as a consequence of changes in PRDM9 DNA-binding domain. However, the reasons for these changes and the rate at which they occur are not known. In this study, we investigated the evolution of human hotspot loci and of PRDM9 target motifs, both in modern and archaic human lineages (Denisovan) to quantify the dynamic of hotspot turnover during the recent period of human evolution. We show that present-day human hotspots are young: they have been active only during the last 10% of the time since the divergence from chimpanzee, starting to be operating shortly before the split between Denisovans and modern humans. Surprisingly, however, our analyses indicate that Denisovan recombination hotspots did not overlap with modern human ones, despite sharing similar PRDM9 target motifs. We further show that high-affinity PRDM9 target motifs are subject to a strong self-destructive drive, known as biased gene conversion (BGC), which should lead to the loss of the majority of them in the next 3 MYR. This depletion of PRDM9 genomic targets is expected to decrease fitness, and thereby to favor new PRDM9 alleles binding different motifs. Our refined estimates of the age and life expectancy of human hotspots provide empirical evidence in support of the Red Queen hypothesis of recombination hotspots evolution.

  12. The red queen model of recombination hotspots evolution in the light of archaic and modern human genomes.

    Directory of Open Access Journals (Sweden)

    Yann Lesecque

    2014-11-01

    Full Text Available Recombination is an essential process in eukaryotes, which increases diversity by disrupting genetic linkage between loci and ensures the proper segregation of chromosomes during meiosis. In the human genome, recombination events are clustered in hotspots, whose location is determined by the PRDM9 protein. There is evidence that the location of hotspots evolves rapidly, as a consequence of changes in PRDM9 DNA-binding domain. However, the reasons for these changes and the rate at which they occur are not known. In this study, we investigated the evolution of human hotspot loci and of PRDM9 target motifs, both in modern and archaic human lineages (Denisovan to quantify the dynamic of hotspot turnover during the recent period of human evolution. We show that present-day human hotspots are young: they have been active only during the last 10% of the time since the divergence from chimpanzee, starting to be operating shortly before the split between Denisovans and modern humans. Surprisingly, however, our analyses indicate that Denisovan recombination hotspots did not overlap with modern human ones, despite sharing similar PRDM9 target motifs. We further show that high-affinity PRDM9 target motifs are subject to a strong self-destructive drive, known as biased gene conversion (BGC, which should lead to the loss of the majority of them in the next 3 MYR. This depletion of PRDM9 genomic targets is expected to decrease fitness, and thereby to favor new PRDM9 alleles binding different motifs. Our refined estimates of the age and life expectancy of human hotspots provide empirical evidence in support of the Red Queen hypothesis of recombination hotspots evolution.

  13. Chemical and biological characterization and clinical evaluation of botanical dietary supplements: a phase I red clover extract as a model.

    Science.gov (United States)

    Piersen, C E; Booth, N L; Sun, Y; Liang, W; Burdette, J E; van Breemen, R B; Geller, S E; Gu, C; Banuvar, S; Shulman, L P; Bolton, J L; Farnsworth, N R

    2004-06-01

    Botanical dietary supplements, as compared with nutritional supplements or single-component pharmaceutical drugs, are typically less-refined preparations derived from bulk plant material and, as such, require a modified approach to their development, production, and evaluation. An integrated, multidisciplinary team of scientific and clinical investigators is required in order to develop high quality phytomedicines and rigorously evaluate their safety and efficacy. Research on botanicals involves unique challenges as plant source materials frequently vary in chemical content and may contain unwanted pesticides, heavy metals, contaminant plant species, or other adulterants. Ideally, a botanical formulation should be standardized, both chemically and biologically, by a combination of analytical techniques and bioassays. This combination approach provides multiple measures by which reproducible quality and efficacy of botanical supplements may be achieved, and is particularly useful for botanical products for which the active compound(s) have not yet been identified. Safety and toxicity should be evaluated during the supplement development process in both in vitro and in vivo systems. A number of liquid chromatography-mass spectrometry methods can aid in the assessment of purity, bioavailability, toxicity, metabolism, and molecular target profiling of botanical extracts. Clinical investigators must appreciate the complexity of multi-component phytomedicines and adjust trial protocols accordingly. This review highlights practical considerations of value to basic science and clinical investigators engaged in the study of botanical supplements. Lessons and examples are drawn from the authors' experience in designing and developing a red clover (Trifolium pratense L.) standardized extract for evaluation in Phase I and Phase II clinical trials.

  14. The host immune enhancing agent Korean red ginseng oil successfully attenuates Brucella abortus infection in a murine model.

    Science.gov (United States)

    Reyes, Alisha Wehdnesday Bernardo; Hop, Huynh Tan; Arayan, Lauren Togonon; Huy, Tran Xuan Ngoc; Park, Soo Jong; Kim, Kwang Dong; Min, WonGi; Lee, Hu Jang; Rhee, Man Hee; Kwak, Yi-Seong; Kim, Suk

    2017-02-23

    Panax ginseng Meyer (Araliaceae), is one of the most valuable traditional Chinese medicines and is used for the treatment of various human diseases. In this study, we elucidated the protective mechanism of the essential oil from Korean red ginseng (RGO) against Brucella infection. The effects of RGO on Brucella abortus viability, NO production, uptake and intracellular growth in macrophages were investigated. Mice were intraperitoneally infected with B. abortus and orally treated with RGO for 14 days. The weights and bacterial numbers from each spleen were monitored, and the sera were evaluated for cytokine production. B. abortus viability was not affected, whereas NO production, internalization and intracellular replication were inhibited in RGO-treated macrophages. Bacterial adherence, F-actin polymerization and MAPK signaling protein phosphorylation (ERK1/2, JNK and p38α) were reduced and the co-localization of B. abortus-containing phagosomes with LAMP-1 was augmented in RGO-treated cells compared to untreated cells. RGO displayed protective effects against cell damage by inhibiting nitrite production during B. abortus infection in macrophages. Moreover, the spleen weight and bacterial burden were lower in the RGO-treated group than in the control group. The uninfected RGO-treated mice displayed increased TNF-α and IFN-γ production, whereas the B. abortus-infected RGO-treated mice showed reduced IL-10 production compared to the control. RGO exhibits protective effects against B. abortus infection in vitro and in vivo, which emphasize the beneficial effects of RGO in the prevention and treatment of brucellosis. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  15. MODELADO DEL PRECIO SPOT DE LA ELECTRICIDAD EN BRASIL USANDO UNA RED NEURONAL AUTORREGRESIVA ELECTRICITY SPOT PRICE MODELLING IN BRASIL USING AN AUTOREGRESSIVE NEURAL NETWORK

    Directory of Open Access Journals (Sweden)

    Juan D Velásquez

    2008-12-01

    Full Text Available Una red neuronal autorregresiva es estimada para el precio mensual brasileño de corto plazo de la electricidad, la cual describe mejor la dinámica de los precios que un modelo lineal autorregresivo y que un perceptrón multicapa clásico que usan las mismas entradas y neuronas en la capa oculta. El modelo propuesto es especificado usando un procedimiento estadístico basado en el contraste del radio de verosimilitud. El modelo pasa una batería de pruebas de diagnóstico. El procedimiento de especificación propuesto permite seleccionar el número de unidades en la capa oculta y las entradas a la red neuronal, usando pruebas estadísticas que tienen en cuenta la cantidad de los datos y el ajuste del modelo a la serie de precios. La especificación del modelo final demuestra que el precio para el próximo mes es una función no lineal del precio actual, de la energía afluente actual y de la energía almacenada en el embalse equivalente en el mes actual y dos meses atrás.An autoregressive neural network model is estimated for the monthly Brazilian electricity spot price, which describes the prices dynamics better than a linear autoregressive model and a classical multilayer perceptron using the same input and neurons in the hidden layer. The proposed model is specified using a statistical procedure based on a likelihood ratio test. The model passes a battery of diagnostic tests. The proposed specification procedure allows us to select the number of units in hidden layer and the inputs to the neural network based on statistical tests, taking into account the number of data and the model fitting to the price time series. The final model specification demonstrates that the price for the next month is a nonlinear function of the current price, the current energy inflow, and the energy saved in the equivalent reservoir in the current month and two months ago.

  16. Integrating HIV Surveillance and Field Services: Data Quality and Care Continuum in King County, Washington, 2010-2015.

    Science.gov (United States)

    Hood, Julia E; Katz, David A; Bennett, Amy B; Buskin, Susan E; Dombrowski, Julia C; Hawes, Stephen E; Golden, Matthew R

    2017-12-01

    To assess how integration of HIV surveillance and field services might influence surveillance data and linkage to care metrics. We used HIV surveillance and field services data from King County, Washington, to assess potential impact of misclassification of prior diagnoses on numbers of new diagnoses. The relationship between partner services and linkage to care was evaluated with multivariable log-binomial regression models. Of the 2842 people who entered the King County HIV Surveillance System in 2010 to 2015, 52% were newly diagnosed, 41% had a confirmed prior diagnosis in another state, and 7% had an unconfirmed prior diagnosis. Twelve percent of those classified as newly diagnosed for purposes of national HIV surveillance self-reported a prior HIV diagnosis that was unconfirmed. Partner services recipients were more likely than nonrecipients to link to care within 30 days (adjusted risk ratio [RR] = 1.10; 95% confidence interval [CI] = 1.03, 1.18) and 90 days (adjusted RR = 1.07; 95% CI = 1.01, 1.14) of diagnosis. Integration of HIV surveillance, partner services, and care linkage efforts may improve the accuracy of HIV surveillance data and facilitate timely linkage to care.

  17. Changes in awareness and use of calorie information after mandatory menu labeling in restaurants in King County, Washington.

    Science.gov (United States)

    Chen, Roxana; Smyser, Michael; Chan, Nadine; Ta, Myduc; Saelens, Brian E; Krieger, James

    2015-03-01

    We examined population-level impact on customer awareness and use and explored potential disparities in outcomes regarding the King County, Washington, regulation requiring chain restaurants to provide calorie information. We analyzed 2008 to 2010 Behavioral Risk Factor Surveillance System data from 3132 English-speaking King County residents aged 18 years and older who reported eating at a regulated chain. We used regression models to assess changes in calorie information awareness and use from prepolicy to postpolicy implementation by customer demographics, health status, and restaurant type. Calorie information awareness and use increased significantly from 2008 to 2010. Unadjusted analyses indicated that the proportion who saw and used calorie information tripled, from 8.1% to 24.8%. Fully adjusted analyses confirmed significant increases. After policy implementation, White, higher income, and obese respondents had greater odds of seeing calorie information. Women, higher income groups, and those eating at a fast-food versus a sit-down chain restaurant were more likely to use this information. Significant increases in calorie information awareness and use following regulation support the population-wide value of this policy. However, improvements varied across race, income, and gender.

  18. A simple model to understand the role of membrane shear elasticity and stress-free shape on the motion of red blood cells in shear flow

    Science.gov (United States)

    Viallat, Annie; Abkarian, Manouk; Dupire, Jules

    2015-11-01

    The analytical model presented by Keller and Skalak on the dynamics of red blood cells in shear flow described the cell as a fluid ellipsoid of fixed shape. It was extended to introduce shear elasticity of the cell membrane. We further extend the model when the cell discoid physiological shape is not a stress-free shape. We show that spheroid stress-free shapes enables fitting experimental data with values of shear elasticity typical to that found with micropipettes and optical tweezers. For moderate shear rates (when RBCs keep their discoid shape) this model enables to quantitatively determine an effective cell viscosity, that combines membrane and hemoglobin viscosities and an effective shear modulus of the membrane that combines shear modulus and stress-free shape. This model allows determining RBC mechanical parameters both in the tanktreading regime for cells suspended in a high viscosity medium, and in the tumbling regime for cells suspended in a low viscosity medium. In this regime,a transition is predicted between a rigid-like tumbling motion and a fluid-like tumbling motion above a critical shear rate, which is directly related to the mechanical parameters of the cell. A*MIDEX (n ANR-11-IDEX-0001-02) funded by the ''Investissements d'Avenir'', Region Languedoc-Roussillon, Labex NUMEV (ANR-10-LABX-20), BPI France project DataDiag.

  19. THE GRAVITATIONAL SHEAR-INTRINSIC ELLIPTICITY CORRELATION FUNCTIONS OF LUMINOUS RED GALAXIES IN OBSERVATION AND IN THE ΛCDM MODEL

    International Nuclear Information System (INIS)

    Okumura, Teppei; Jing, Y. P.

    2009-01-01

    We examine whether the gravitational shear-intrinsic ellipticity (GI) correlation function of the luminous red galaxies (LRGs) can be modeled with the distribution function of a misalignment angle advocated recently by Okumura et al. For this purpose, we have accurately measured the GI correlation for the LRGs in the Data Release 6 (DR6) of the Sloan Digital Sky Survey (SDSS), which confirms the results of Hirata et al. who used the DR4 data. By comparing the GI correlation functions in the simulation and in the observation, we find that the GI correlation can be modeled in the current ΛCDM model if the misalignment follows a Gaussian distribution with a zero mean and a typical misalignment angle σ θ = 34.9 +1.9 -2.1 degrees. We also find a correlation between the axis ratios and intrinsic alignments of LRGs. This effect should be taken into account in theoretical modeling of the GI and intrinsic ellipticity-ellipticity correlations for weak lensing surveys.

  20. Red blood cell production

    Science.gov (United States)

    ... bone marrow of bones. Stem cells in the red bone marrow called hemocytoblasts give rise to all of the formed elements in blood. If a hemocytoblast commits to becoming a cell called a proerythroblast, it will develop into a new red blood cell. The formation of a red blood ...

  1. RED-ML

    DEFF Research Database (Denmark)

    Xiong, Heng; Liu, Dongbing; Li, Qiye

    2017-01-01

    using diverse RNA-seq datasets, we have developed a software tool, RED-ML: RNA Editing Detection based on Machine learning (pronounced as "red ML"). The input to RED-ML can be as simple as a single BAM file, while it can also take advantage of matched genomic variant information when available...

  2. redGEM: Systematic reduction and analysis of genome-scale metabolic reconstructions for development of consistent core metabolic models.

    Directory of Open Access Journals (Sweden)

    Meric Ataman

    2017-07-01

    Full Text Available Genome-scale metabolic reconstructions have proven to be valuable resources in enhancing our understanding of metabolic networks as they encapsulate all known metabolic capabilities of the organisms from genes to proteins to their functions. However the complexity of these large metabolic networks often hinders their utility in various practical applications. Although reduced models are commonly used for modeling and in integrating experimental data, they are often inconsistent across different studies and laboratories due to different criteria and detail, which can compromise transferability of the findings and also integration of experimental data from different groups. In this study, we have developed a systematic semi-automatic approach to reduce genome-scale models into core models in a consistent and logical manner focusing on the central metabolism or subsystems of interest. The method minimizes the loss of information using an approach that combines graph-based search and optimization methods. The resulting core models are shown to be able to capture key properties of the genome-scale models and preserve consistency in terms of biomass and by-product yields, flux and concentration variability and gene essentiality. The development of these "consistently-reduced" models will help to clarify and facilitate integration of different experimental data to draw new understanding that can be directly extendable to genome-scale models.

  3. Of Disasters and Dragon Kings: A Statistical Analysis of Nuclear Power Incidents and Accidents.

    Science.gov (United States)

    Wheatley, Spencer; Sovacool, Benjamin; Sornette, Didier

    2017-01-01

    We perform a statistical study of risk in nuclear energy systems. This study provides and analyzes a data set that is twice the size of the previous best data set on nuclear incidents and accidents, comparing three measures of severity: the industry standard International Nuclear Event Scale, the Nuclear Accident Magnitude Scale of radiation release, and cost in U.S. dollars. The rate of nuclear accidents with cost above 20 MM 2013 USD, per reactor per year, has decreased from the 1970s until the present time. Along the way, the rate dropped significantly after Chernobyl (April 1986) and is expected to be roughly stable around a level of 0.003, suggesting an average of just over one event per year across the current global fleet. The distribution of costs appears to have changed following the Three Mile Island major accident (March 1979). The median cost became approximately 3.5 times smaller, but an extremely heavy tail emerged, being well described by a Pareto distribution with parameter α = 0.5-0.6. For instance, the cost of the two largest events, Chernobyl and Fukushima (March 2011), is equal to nearly five times the sum of the 173 other events. We also document a significant runaway disaster regime in both radiation release and cost data, which we associate with the "dragon-king" phenomenon. Since the major accident at Fukushima (March 2011) occurred recently, we are unable to quantify an impact of the industry response to this disaster. Excluding such improvements, in terms of costs, our range of models suggests that there is presently a 50% chance that (i) a Fukushima event (or larger) occurs every 60-150 years, and (ii) that a Three Mile Island event (or larger) occurs every 10-20 years. Further-even assuming that it is no longer possible to suffer an event more costly than Chernobyl or Fukushima-the expected annual cost and its standard error bracket the cost of a new plant. This highlights the importance of improvements not only immediately following

  4. Insights from ecological niche modeling on the taxonomic distinction and niche differentiation between the black-spotted and red-spotted tokay geckoes (Gekko gecko)

    OpenAIRE

    Zhang, Yueyun; Chen, Chongtao; Li, Li; Zhao, Chengjian; Chen, Weicai; Huang, Yong

    2014-01-01

    The black-spotted tokay and the red-spotted tokay are morphologically distinct and have largely allopatric distributions. The black-spotted tokay is characterized by a small body size and dark skin with sundry spots, while the red-spotted tokay has a relatively large body size and red spots. Based on morphological, karyotypic, genetic, and distribution differences, recent studies suggested their species status; however, their classifications remain controversial, and additional data such as e...

  5. Speciation, range contraction and extinction in the endemic New Zealand King Shag complex.

    Science.gov (United States)

    Rawlence, Nicolas J; Till, Charlotte E; Easton, Luke J; Spencer, Hamish G; Schuckard, Rob; Melville, David S; Scofield, R Paul; Tennyson, Alan J D; Rayner, Matt J; Waters, Jonathan M; Kennedy, Martyn

    2017-10-01

    New Zealand's endemic King Shag (Leucocarbo carunculatus) has occupied only a narrow portion of the northeastern South Island for at least the past 240years. However, pre-human Holocene fossil and archaeological remains have suggested a far more widespread distribution of the three Leucocarbo species (King, Otago, Foveaux) on mainland New Zealand at the time of Polynesian settlement in the late 13th Century CE. We use modern and ancient DNA, and morphometric and osteological analyses, of modern King Shags and Holocene fossil Leucocarbo remains to assess the pre-human distribution and taxonomic status of the King Shag on mainland New Zealand, and the resultant conservation implications. Our analyses show that the King Shag was formerly widespread around southern coasts of the North Island and the northern parts of the South Island but experienced population and lineage extinctions, and range contraction, probably after Polynesian arrival. This history parallels range contractions of other New Zealand seabirds. Conservation management of the King Shag should take into account this species narrow distribution and probable reduced genetic diversity. Moreover, combined genetic, morphometric and osteological analyses of prehistoric material from mainland New Zealand suggest that the now extinct northern New Zealand Leucocarbo populations comprised a unique lineage. Although these distinctive populations were previously assigned to the King Shag (based on morphological similarities and geographic proximity to modern Leucocarbo populations), we herein describe them as a new species, the Kohatu Shag (Leucocarbo septentrionalis). The extinction of this species further highlights the dramatic impacts Polynesians and introduced predators had on New Zealand's coastal and marine biodiversity. The prehistoric presence of at least four species of Leucocarbo shag on mainland NZ further highlights its status as a biodiversity hotspot for Phalacrocoracidae. Copyright © 2017 Elsevier

  6. Where to deliver baits for deworming urban red foxes for Echinococcus multilocularis control: new protocol for micro-habitat modeling of fox denning requirements.

    Science.gov (United States)

    Ikeda, Takako; Yoshimura, Masashi; Onoyama, Keiichi; Oku, Yuzaburo; Nonaka, Nariaki; Katakura, Ken

    2014-08-06

    Deworming wild foxes by baiting with the anthelmintic praziquantel is being established as a preventive technique against environmental contamination with Echinococcus multilocularis eggs. Improvement of the cost-benefit performance of baiting treatment is required urgently to raise and maintain the efficacy of deworming. We established a spatial model of den site selection by urban red foxes, the definitive host, to specify the optimal micro-habitats for delivering baits in a new modeling approach modified for urban fox populations. The model was established for two cities (Obihiro and Sapporo) in Hokkaido, Japan, in which a sylvatic cycle of E. multilocularis is maintained. The two cities have different degrees of urbanization. The modeling process was designed to detect the best combination of key environmental factors and spatial scale that foxes pay attention to most (here named 'heeding range') when they select den sites. All possible models were generated using logistic regression analysis, with "presence" or "absence" of fox den as the objective variable, and nine landscape categories customized for urban environments as predictor variables to detect the best subset of predictors. This procedure was conducted for each of ten sizes of concentric circles from dens and control points to detect the best circle size. Out of all models generated, the most parsimonious model was selected using Akaike's Information Criterion (AIC) inspection. Our models suggest that fox dens in Obihiro are located at the center of a circle with 500 m radius including low percentages of wide roads, narrow roads, and occupied buildings, but high percentages of green covered areas; the dens in Sapporo within 300 m radius with low percentages of wide roads, occupied buildings, but high percentages of riverbeds and green covered areas. The variation of the models suggests the necessity of accumulating models for various types of cities in order to reveal the patterns of the model. Our

  7. Synergistic Use of Remote Sensing and Modeling to Assess an Anomalously High Chlorophyll-a Event during Summer 2015 in the South Central Red Sea

    Directory of Open Access Journals (Sweden)

    Wenzhao Li

    2017-07-01

    Full Text Available An anomalously high chlorophyll-a (Chl-a event (>2 mg/m3 during June 2015 in the South Central Red Sea (17.5° to 22°N, 37° to 42°E was observed using Moderate Resolution Imaging Spectroradiometer (MODIS data from the Terra and Aqua satellite platforms. This differs from the low Chl-a values (<0.5 mg/m3 usually encountered over the same region during summertime. To assess this anomaly and possible causes, we used a wide range of oceanographical and meteorological datasets, including Chl-a concentrations, sea surface temperature (SST, sea surface height (SSH, mixed layer depth (MLD, ocean current velocity and aerosol optical depth (AOD obtained from different sensors and models. Findings confirmed this anomalous behavior in the spatial domain using Hovmöller data analysis techniques, while a time series analysis addressed monthly and daily variability. Our analysis suggests that a combination of factors controlling nutrient supply contributed to the anomalous phytoplankton growth. These factors include horizontal transfer of upwelling water through eddy circulation and possible mineral fertilization from atmospheric dust deposition. Coral reefs might have provided extra nutrient supply, yet this is out of the scope of our analysis. We thought that dust deposition from a coastal dust jet event in late June, coinciding with the phytoplankton blooms in the area under investigation, might have also contributed as shown by our AOD findings. However, a lag cross correlation showed a two- month lag between strong dust outbreak and the high Chl-a anomaly. The high Chl-a concentration at the edge of the eddy emphasizes the importance of horizontal advection in fertilizing oligotrophic (nutrient poor Red Sea waters.

  8. Estimates of recharge in two arid basin aquifers: a model of spatially variable net infiltration and its implications (Red Light Draw and Eagle Flats, Texas, USA)

    Science.gov (United States)

    Robertson, Wendy Marie; Sharp, John M.

    2013-12-01

    Methods of estimating recharge in arid basin aquifers (such as the 1 % rule, Maxey-Eakin method, storm-runoff infiltration and others) overlook the potential contribution of direct recharge on the basin floors. In the Trans-Pecos region of west Texas, USA, this has resulted in potential recharge and solute flux to basin aquifers being ignored. Observed trends in groundwater nitrate (NO3 -) concentrations and the presence of young (floors. A spatially variable net infiltration model (INFIL 3.0.1) was used to estimate the volume and spatial distribution of potential recharge to two basins: Red Light Draw and Eagle Flats. The INFIL model provides insight into the mechanisms by which recharge and solute flux occurs in arid basin systems. This method demonstrated that recharge is widespread; it is not limited to the mountainous areas and mountain-front recharge mechanisms, and up to 15 % of total potential recharge in these basins occurs across widespread areas of the basin floors. Models such as this should improve scientific understanding and sustainable management of arid basin aquifers in Texas and elsewhere.

  9. A medical cyclotron, facilities and program at the King Faisal Specialist Hospital and Research Centre

    International Nuclear Information System (INIS)

    Barrall, R.C.; Feteih, N.; Merendino, K.A.

    1983-01-01

    A new Cancer Therapy Institute at the King Faisal Specialist Hospital and Research Centre in Riyadh, Saudi Arabia became fully operational in November 1982. The new building incorporates extensive facilities for the production of medically useful radionuclides and additional cancer treatment capability including two neutron therapy machines and an electron linear accelerator. A model CS30 medical cyclotron with 7 beam lines was supplied by the Cyclotron Corporation, Berkeley, California. The hot laboratory facilities include five hot cells and a radioactive gas processing station to deliver short-lived radioactive gases to a station in the positron emission tomography (PET) camera room. Facilities for radiopharmaceutical processing, quality control and packaging of radioactive materials are provided. A PDP 11/70 computer controls a fully automated air monitoring system while other computers control permission to operate equipment and monitor status of shielding doors and radiation levels both inside and outside the shielded rooms. A high level gamma irradiation facility for medical sterilization and other uses, designed to hold up to 2 million Curies of cobalt-60 is also provided. The new facility will produce short lived radionuclides for hospitals and other institutions in the Kingdom and the nearby area while also providing an opportunity to investigate the effectiveness of high energy neutrons in cancer treatment

  10. Predictors and correlations of emotional intelligence among medical students at King Abdulaziz University, Jeddah.

    Science.gov (United States)

    Ibrahim, Nahla Khamis; Algethmi, Wafaa Ali; Binshihon, Safia Mohammad; Almahyawi, Rawan Aesh; Alahmadi, Razan Faisal; Baabdullah, Maha Yousef

    2017-01-01

    To determine the predictors of Emotional Intelligence (EI), and its relationship with academic performance, leadership capacity, self-efficacy and the perceived stress between medical students at King Abdulaziz University, Jeddah, Saudi Arabia. A cross-sectional study was done among 540 students selected through a multi-stage stratified random sampling method during 2015/2016. A standardized, confidential data collection sheet was used. It included Schutte Self-Report Emotional Intelligence (SSREI) scale, Authentic Leadership questionnaire, General Self-Efficacy Scale and the short version of Perceived Stress Scale (PSS-4). Both descriptive and inferential statistics were done, and a multiple linear regression model was constructed. The predictors of high EI were gender (female), increasing age, and being non-smoker. EI was positively associated with better academic performance, leadership capacity and self-efficacy. It was negatively correlated to perceived-stress. Female gender, age, non-smoking were the predictors of high EI. Conduction of holistic training programs on EI, leadership and self-efficacy are recommended. More smoking control programs and stress management courses are required.

  11. Screening Utility of the King-Devick Test in Mild Cognitive Impairment and Alzheimer Disease Dementia.

    Science.gov (United States)

    Galetta, Kristin M; Chapman, Kimberly R; Essis, Maritza D; Alosco, Michael L; Gillard, Danielle; Steinberg, Eric; Dixon, Diane; Martin, Brett; Chaisson, Christine E; Kowall, Neil W; Tripodis, Yorghos; Balcer, Laura J; Stern, Robert A

    2017-01-01

    The King-Devick (K-D) test is a 1 to 2 minute, rapid number naming test, often used to assist with detection of concussion, but also has clinical utility in other neurological conditions (eg, Parkinson disease). The K-D involves saccadic eye and other eye movements, and abnormalities thereof may be an early indicator of Alzheimer disease (AD)-associated cognitive impairment. No study has tested the utility of the K-D in AD and we sought to do so. The sample included 206 [135 controls, 39 mild cognitive impairment (MCI), and 32 AD dementia] consecutive subjects from the Boston University Alzheimer's Disease Center registry undergoing their initial annual evaluation between March 2013 and July 2015. The K-D was administered during this period. Areas under the receiver operating characteristic curves generated from logistic regression models revealed the K-D test distinguished controls from subjects with cognitive impairment (MCI and AD dementia) [area under the curve (AUC)=0.72], MCI (AUC=0.71) and AD dementia (AUC=0.74). K-D time scores between 48 and 52 seconds were associated with high sensitivity (>90.0%) and negative predictive values (>85.0%) for each diagnostic group. The K-D correlated strongly with validated attention, processing speed, and visual scanning tests. The K-D test may be a rapid and simple effective screening tool to detect cognitive impairment associated with AD.

  12. Mortality of patients hospitalized for active tuberculosis in King Abdulaziz University Hospital, Jeddah, Saudi Arabia.

    Science.gov (United States)

    Aljohaney, Ahmed A

    2018-03-01

    To determine the mortality rates and predictors among patients hospitalized with active tuberculosis (TB) at King Abdulaziz University Hospital (KAUH) in Jeddah. A retrospective study was performed on 291 active TB patients hospitalized in KAUH, Jeddah, Saudi Arabia from December 2011 to December 2016. Medical records were collected and evaluated using a dedicated data extraction sheet. The records included demographics, clinical, radiological, laboratory, and drug resistance data. Of the 291 patients, 168 had pulmonary TB, 39 had extrapulmonary TB, and 84 had both pulmonary and extrapulmonary TB. After a mean hospital stay of 1.74 months, 85.9% were successfully treated and discharged. However, 14% died in the hospital after a mean stay of 1.87 months. Predictors of inpatient TB mortality were older age, congestive heart failure, renal failure, diabetes mellitus, chronic lung disease, hepatitis B virus infection, bilateral pulmonary TB, miliary TB, pleural effusion, and leukopenia. In particular, a logistic regression model revealed a mortality probability of 90% in patients older than 65 with congestive heart failure and bilateral lung involvement. However, drug resistance did not significantly affect the mortality rate. Conclusions: The inpatient TB mortality rate was lower than mortality rates described previously. Nevertheless, early recognition, appropriate treatments, and education for patients and caregivers concerning treatment, efficient medical management, and effective preventive measures can further reduce mortality.

  13. An ideal for leadership - Psalm 72: The (wise king - Royal mediation of God�s universal reign

    Directory of Open Access Journals (Sweden)

    D. J. Human

    2002-08-01

    Full Text Available Psalm 72 propounds illuminating theological perspectives on leadership. The central figure in the psalm is the king. Throughout the Ancient Near East the king played a distinctive role, not only in contemporary politics, but also in religious life. Despite several differences from the other nations, kingship in Israel was rooted in the worldview of the ancient East. Yahweh, like other gods, commissioned the king for his tasks. The wise king in Israel, who alludes in Psalm 72 to the figure of Solomon, is obliged to rule with justice in order to maintain peace and prosperity in society.

  14. The Acute Red Eye

    Directory of Open Access Journals (Sweden)

    Megan Boysen Osborn

    2016-09-01

    Full Text Available Audience: This modified team-based learning (mTBL exercise is appropriate for junior or senior emergency medicine learners. Introduction: The acute red eye is a common chief complaint in the emergency department. It is essential that the emergency physician be knowledgeable about the differential diagnosis for the acute red eye and be able to distinguish between benign and sinister causes of the acute red eye. Objectives: By the end of this educational session, the learner will: 1 list 10 major causes for an acute red eye; 2 describe historical features that help distinguish between benign and serious causes of the acute red eye; 3 describe physical examination features that help distinguish between benign and serious causes of the acute red eye; and 4 use historical and physical examination features to distinguish between the 10 different causes of the acute red eye. Method: This is an mTBL session.

  15. Johann Bernhard Aloys von Gudden and the Mad King of Bavaria.

    Science.gov (United States)

    Bhattacharyya, Kalyan B

    2017-01-01

    Bernhard von Gudden was a psychiatrist in Prussia and he was summoned in March 1886 to examine King Ludwig II for his apparently insane activities like, profligate spending and erratic behaviour. A team of four estimable psychiatrists pronounced that he was not capable ruling. Consequently, he was dethroned and kept in a castle under supervision of von Gudden. Gudden championed the idea of 'no restraint' and advocated free movement of insane persons and one evening in June, he accompanied the King during an evening stroll to a lake. A few hours later, the corpus of both of them were recovered under mysterious circumstances. Autopsy suggested that the King was drowned but no post-mortem examination was performed on von Gudden. There are plenty of controversies regarding their death like, murder, accidental death or even natural death from cardiac arrest following immersion in cold water, but no incontrovertible conclusion could be arrived at, even after scrupulous analysis by historians and even the diagnosis of insanity of the King has been doubted. Some even suggested that the opinion of psychiatrists were sought as a pretense in order to depose the King.

  16. Arctic observers: Richard King, monogenism and the historicisation of Inuit through travel narratives.

    Science.gov (United States)

    Sera-Shriar, Efram

    2015-06-01

    In 1848 the ethnologist, surgeon and Arctic explorer Richard King (1810-1876) published a three-part series on Inuit in the Journal of the Ethnological Society of London. This series provided a detailed history of Inuit from the eleventh century to the early nineteenth century. It incorporated a mixture of King's personal observations from his experience travelling to the Arctic as a member of George Back's expedition (1833-1835), and the testimonies of other contemporary and historical actors who had written on the subject. The aim was to historicise Inuit through the use of travel reports and show persistent features among the race. King was a monogenist and his sensitive recasting of Inuit was influenced by his participation in a research community actively engaged in humanitarian and abolitionist causes. The physician and ethnologist Thomas Hodgkin (1798-1866) argued that King's research on Inuit was one of the best ethnological approaches to emulate and that it set the standard for the nascent discipline. If we are to take seriously Hodgkin's claim, we should look at how King constructed his depiction of Inuit. There is much to be gained by investigating the practices of nineteenth-century ethnologists because it strengthens our knowledge of the discipline's past and shows how modern understandings of races were formed. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Hedging in Political Discourse: Evidence from the Speeches of King Abdullah II of Jordan

    Directory of Open Access Journals (Sweden)

    Rabab’ah Ghaleb

    2015-07-01

    Full Text Available This paper reports on the findings of a study that aimed to identify the linguistic items which act as hedges in the speeches of King Abdullah II of Jordan, as well as to examine the pragmatic functions of these devices. Twenty-five political speeches of King Abdullah II, randomly selected from the official website of King Abdullah (see Appendix, were analyzed adopting Salager-Meyer’s (1994 taxonomy. The study revealed that the most frequently used hedging device in King Abdullah’s speech is modal auxiliaries, and the most frequently used hedging device subcategory is the modal auxiliary “can”. The findings suggest that these hedging devices fulfil several pragmatic functions. These findings contribute to understanding that speaking a second language (Arabic, in the case of King Abdullah II neither affects the types of hedging devices nor the functions these devices perform. Moreover, contrary to scientific discourse (e.g., medicine, the research concludes that political discourse as a non-scientific genre resorts to hedging devices to express indirectness, politeness, lack of commitment and probability.

  18. The Russian secret service and King Alexander Obrenović of Serbia (1900-1903

    Directory of Open Access Journals (Sweden)

    Rajić Suzana

    2012-01-01

    Full Text Available The period of 1900-1903 saw three phases of cooperation between the Rus­sian Secret Service (Okhrana and King Alexander Obrenović of Serbia. It is safe to say that the Secret Service operated in Serbia as an extended arm of the Russian Ministry of Foreign Affairs, i.e. of its diplomatic mission in Belgrade. Its goal was to fortify the position of Russia in Serbia after King Alexander’s wedding and the departure of his father, ex-King Milan (who abdicated in 1889 in favour of his minor son, from the country. The Serbian King, however, benefited little from the cooperation, because he did not receive assistance from the Secret Service when he needed it most. Thus, the issue of conspiracy against his life was lightly treated throughout 1902 until his assassination in 1903. In the third and last period of cooperation, from the beginning of 1902 until the King’s assassination on 11 June 1903,1 the Russian ministries of Internal and Foreign Affairs forbade the agents to receive money from the Serbian King and relieved them of any duty regarding the protection of his life. [Projekat Ministarstva nauke Republike Srbije, br. 177014: Serbian nation: Integrating and disintegrating processes

  19. Surface complexation modeling of groundwater arsenic mobility: Results of a forced gradient experiment in a Red River flood plain aquifer, Vietnam

    Science.gov (United States)

    Jessen, Søren; Postma, Dieke; Larsen, Flemming; Nhan, Pham Quy; Hoa, Le Quynh; Trang, Pham Thi Kim; Long, Tran Vu; Viet, Pham Hung; Jakobsen, Rasmus

    2012-12-01

    Three surface complexation models (SCMs) developed for, respectively, ferrihydrite, goethite and sorption data for a Pleistocene oxidized aquifer sediment from Bangladesh were used to explore the effect of multicomponent adsorption processes on As mobility in a reduced Holocene floodplain aquifer along the Red River, Vietnam. The SCMs for ferrihydrite and goethite yielded very different results. The ferrihydrite SCM favors As(III) over As(V) and has carbonate and silica species as the main competitors for surface sites. In contrast, the goethite SCM has a greater affinity for As(V) over As(III) while PO43- and Fe(II) form the predominant surface species. The SCM for Pleistocene aquifer sediment resembles most the goethite SCM but shows more Si sorption. Compiled As(III) adsorption data for Holocene sediment was also well described by the SCM determined for Pleistocene aquifer sediment, suggesting a comparable As(III) affinity of Holocene and Pleistocene aquifer sediments. A forced gradient field experiment was conducted in a bank aquifer adjacent to a tributary channel to the Red River, and the passage in the aquifer of mixed groundwater containing up to 74% channel water was observed. The concentrations of As (SCM correctly predicts desorption for As(III) but for Si and PO43- it predicts an increased adsorption instead of desorption. The goethite SCM correctly predicts desorption of both As(III) and PO43- but failed in the prediction of Si desorption. These results indicate that the prediction of As mobility, by using SCMs for synthetic Fe-oxides, will be strongly dependent on the model chosen. The SCM based on the Pleistocene aquifer sediment predicts the desorption of As(III), PO43- and Si quite superiorly, as compared to the SCMs for ferrihydrite and goethite, even though Si desorption is still somewhat under-predicted. The observation that a SCM calibrated on a different sediment can predict our field results so well suggests that sediment based SCMs may be a

  20. Mixed connective tissue disease: The King Faisal Specialist Hospital experience

    International Nuclear Information System (INIS)

    Al-Rayes, H.; Al-Sheikh, A.; Al-Dalaan, A.; Al-Saleh, S.

    2002-01-01

    The aim of this study was to assess the clinical presentation, complications and serological analysis of mixed connective tissue disease (MCTD) at King Faisal Specialist Hospital and Research Centre (KFSHRC), and to determine the long-term clinical and immunologic outcomes. This was a retrospective study with prospective follow-up of 18 patients with MCTD who were followed at KFSHRC between 1982 and 1999. The age at onset of the disease ranged from 6 to 44 years, with mean age of 17.9 years. The female to male ratio was 2.5:1 and the mean follow-up time was 5 years. The most frequent presenting symptoms were arthralgia in all patients, Raynaud's phenomenon in 16 patients (88%) and swollen hands in 11 patients (61%). Arthritis was seen in 12 patients in (67%) and definite myositis in 10 patients (58%). The most common skin rashes encountered included lupus-like rash in 8 patients (44%) and cutaneous vasculitis in 5 patients (28%). Pulmonary hypertension occurred in 4 patients (22%). Other clinical manifestations encountered were esophageal hypomotility in 10 patients (56%), myocarditis in 2 patients (11%) and proteinurea in 2 patients (11%), while various neurological manifestations were present in 7 patients (39%). All patients exhibited higher titer of ANA and anti-nRNP antibodies. Five of the 18 patients (28%) had marked reduction in the anti-nRNP during remission. Following treatment, features of inflammation as well as Raynaud's phenomenon and esophageal hypomotility diminished, while pulmonary hypertension persisted. A favorable outcome was observed in 12 patients (67%), 3 patients (17%) had continued active disease, while 3 patients (17%) died, with death related to pulmonary hypertension occurring in 2 patients (11%). The studied patients demonstrated the typical clinical and serological findings of MCTD, which support the correlation between anti-nRNP antibody specificities and MCTD. Autoantibody reactivity against nRNP polypeptides tends to regress during

  1. King's Health Partners' Prostate Cancer Biobank (KHP PCaBB).

    Science.gov (United States)

    Saifuddin, S R; Devlies, W; Santaolalla, A; Cahill, F; George, G; Enting, D; Rudman, S; Cathcart, P; Challacombe, B; Dasgupta, P; Galustian, C; Chandra, A; Chowdhury, S; Gillett, C; Van Hemelrijck, M

    2017-11-22

    The KHP PCaBB was established in 2013 and recruits donors from the Urology or Oncology Departments at Guy's Hospital in London (UK). Prostate cancer patients may be approached to give their consent for biobanking at any point in their treatment pathway, which allows residual material from their earlier diagnosis to be transferred and used by the Biobank. Currently, patients are specifically asked to donate samples of blood and surplus prostate tissue as well as permitting access to their clinical and pathological data that continues to be added throughout the course of their disease. Between 2013 and 2015, 549 prostate cancer patients gave their consent to the biobank and, the tissue repository collected 489 blood samples, 120 frozen prostate tissue samples and 1064 formalin fixed paraffin embedded diagnostic blocks.Prostate cancer has become a chronic disease in a large proportion of men, with many men receiving multiple subsequent treatments, and their treatment trajectory often spanning over decades. Therefore, this resource aims to provide an ideal research platform to explore potential variations in treatment response as well as disease markers in the different risk categories for prostate cancer.A recent audit of the KHP PCaBB revealed that between 2013 and 2015, 1796 patients were diagnosed with prostate cancer at King's Health Partners (KHP), out of which 549 (30.6%) gave their consent to KHP PCaBB. Comparisons between demographic and clinical characteristics of patients who had consented compared to the total patient population revealed that the KHP PCaBB is demographically representative of the total prostate cancer patient population seen in Guy's and St Thomas' NHS Foundation Trust (GSTT). We observed no differences in distribution of ethnicity (p = 0.507) and socioeconomic status (p = 0.097). Some differences were observed in clinical characteristics, specifically with treatment type - which differed significantly between the patients who had

  2. Detection of sentinel nodes by a novel red-fluorescent dye, ATX-S10Na (II), in an orthotopic xenograft rat model of human gastric carcinoma.

    Science.gov (United States)

    Koyama, Tomoki; Tsubota, Akihito; Nariai, Koichi; Yoshikawa, Tetsuya; Mitsunaga, Makoto; Sumi, Makoto; Nimura, Hiroshi; Yanaga, Katsuhiko; Yumoto, Yoko; Mabashi, Yasuo; Takahashi, Hiroshi

    2007-01-01

    We developed a new imaging system to detect sentinel nodes (SNs) using a novel fluorescent tracer, ATX-S10Na(II), and investigated its usefulness in an animal model. Human gastric carcinoma cells were implanted orthotopically into nude rats. ATX-S10Na(II) was injected subserosally into the primary tumor lesion, and visualized by a fluorescence spectro-laparoscope. Presence of tumor cells in lymph nodes (LNs) was determined by RT-PCR specific for human beta-actin. Injection of ATX-S10Na(II) was successful in 27 tumor-bearing rats. A red fluorescence was incorporated into the left gastric and hepatic LNs in 25 and 2 rats, respectively. Of note, human beta-actin was detected in most of these LNs. Fluorescence was not detected in LNs that did not contain cancer. ATX-S10Na(II) is useful for the detection of cancer-containing SNs in an animal model of gastric carcinoma, and may serve as a novel tracer in SN navigation surgery. (c) 2006 Wiley-Liss, Inc.

  3. Protective effect of Korean Red Ginseng against chemotherapeutic drug-induced premature catagen development assessed with human hair follicle organ culture model.

    Science.gov (United States)

    Keum, Dong In; Pi, Long-Quan; Hwang, Sungjoo Tommy; Lee, Won-Soo

    2016-04-01

    Chemotherapy-induced alopecia (CIA) is one of the most distressing side effects for patients undergoing chemotherapy. This study evaluated the protective effect of Korean Red Ginseng (KRG) on CIA in a well-established in vitro human hair follicle organ culture model as it occurs in vivo. We examined whether KRG can prevent premature hair follicle dystrophy in a human hair follicle organ culture model during treatment with a key cyclophosphamide metabolite, 4-hydroperoxycyclophosphamide (4-HC). 4-HC inhibited human hair growth, induced premature catagen development, and inhibited proliferation and stimulated apoptosis of hair matrix keratinocytes. In addition, 4-HC increased p53 and Bax protein expression and decreased Bcl2 protein expression. Pretreatment with KRG protected against 4-HC-induced hair growth inhibition and premature catagen development. KRG also suppressed 4-HC-induced inhibition of matrix keratinocyte proliferation and stimulation of matrix keratinocyte apoptosis. Moreover, KRG restored 4-HC-induced p53 and Bax/Bcl2 expression. Overall, our results indicate that KRG may protect against 4-HC-induced premature catagen development through modulation of p53 and Bax/Bcl2 expression.

  4. Therapeutic Effects of Korean Red Ginseng Extract in a Murine Model of Atopic Dermatitis: Anti-pruritic and Anti-inflammatory Mechanism.

    Science.gov (United States)

    Lee, Hyun Joo; Cho, Sang Hyun

    2017-04-01

    Korean red ginseng (KRG) and ginsenosides exhibit diverse biological effects, including anti-inflammatory and anti-allergic. We aimed to investigate the therapeutic effect of KRG in a murine model of atopic dermatitis (AD) is mediated whether by diminishing the pruritus or by suppressing the inflammation. Thirty NC/Nga mice were randomly divided to 5 groups. AD-like skin lesions were induced by percutaneous challenge with 2,4,6-trinitro-1-chrolobenzene (TNCB) on the ears and backs of NC/Nga mice. KRG extract, evening primrose oil, cyclosporine, and phosphate-buffered saline were administered orally by a gastric tube. Each study group was also divided into scratching-permitted and scratching-restricted subgroups to evaluate the impact of scratching behavior on AD. The effects of KRG and the other agents were assessed by measuring the clinical severity score, ear thickness, extent of transepidermal water loss (TEWL), number of scratching movements, total systemic immunoglobulin E (IgE) and interleukin (IL)-31 levels, histologic changes of cutaneous lesions, and mRNA expression levels of tumor necrosis factor (TNF)-α, interferon (IFN)-γ, thymic stromal lymphopoietin (TSLP), and IL-31. KRG exerts therapeutic effects against AD by inhibiting the T helper 2 (Th2) mediated inflammation as well as by diminishing the itching sensation. Moreover, restricting scratching behavior suppresses the vicious cycle of itching and scratching, thus reducing clinical and systemic inflammation in our murine model of AD. © 2017 The Korean Academy of Medical Sciences.

  5. Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease

    Science.gov (United States)

    De Franceschi, Lucia; Franco, Robert S.; Bertoldi, Mariarita; Brugnara, Carlo; Matté, Alessandro; Siciliano, Angela; Wieschhaus, Adam J.; Chishti, Athar H.; Joiner, Clinton H.

    2013-01-01

    Sickle cell disease (SCD) is a globally distributed hereditary red blood cell (RBC) disorder. One of the hallmarks of SCD is the presence of circulating dense RBCs, which are important in SCD-related clinical manifestations. In human dense sickle cells, we found reduced calpastatin activity and protein expression compared to either healthy RBCs or unfractionated sickle cells, suggesting an imbalance between activator and inhibitor of calpain-1 in favor of activator in dense sickle cells. Calpain-1 is a nonlysosomal cysteine proteinase that modulates multiple cell functions through the selective cleavage of proteins. To investigate the relevance of this observation in vivo, we evaluated the effects of the orally active inhibitor of calpain-1, BDA-410 (30 mg/kg/d), on RBCs from SAD mice, a mouse model for SCD. In SAD mice, BDA-410 improved RBC morphology, reduced RBC density (D20; from 1106±0.001 to 1100±0.001 g/ml; Pcell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease. PMID:23085996

  6. Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis.

    Science.gov (United States)

    Figueira, M E; Câmara, M B; Direito, R; Rocha, J; Serra, A T; Duarte, C M M; Fernandes, A; Freitas, M; Fernandes, E; Marques, M C; Bronze, M R; Sepodes, B

    2014-12-01

    Berries are an important dietary source of fibres, vitamins, minerals and some biologically active non-nutrients. A red raspberry fruit extract was characterized in terms of phenolic content and the anti-inflammatory properties and protective effects were evaluated in two experimental models of inflammation. The antioxidant potential of the extract, the cellular antioxidant activity and the effects over neutrophils' oxidative burst were also studied to provide a mechanistic insight for the anti-inflammatory effects observed. The extract was administered in a dose of 15 mg kg(-1), i.p. and significantly inhibited paw oedema formation in the rat. The same dose was administered via i.p. and p.o. routes in the collagen-induced arthritis model in the rat. The extract showed pharmacological activity and was able to significantly reduce the development of clinical signs of arthritis and markedly reduce the degree of bone resorption, soft tissue swelling and osteophyte formation, preventing articular destruction in treated animals.

  7. Model-Based Estimation of Forest Canopy Height in Red and Austrian Pine Stands Using Shuttle Radar Topography Mission and Ancillary Data: a Proof-of-Concept Study

    Energy Technology Data Exchange (ETDEWEB)

    Brown Jr., C G; Sarabandi, K; Pierce, L E

    2007-04-06

    In this paper, accurate tree stand height retrieval is demonstrated using C-band Shuttle Radar Topography Mission (SRTM) height and ancillary data. The tree height retrieval algorithm is based on modeling uniform tree stands with a single layer of randomly oriented vegetation particles. For such scattering media, the scattering phase center height, as measured by SRTM, is a function of tree height, incidence angle, and the extinction coefficient of the medium. The extinction coefficient for uniform tree stands is calculated as a function of tree height and density using allometric equations and a fractal tree model. The accuracy of the proposed algorithm is demonstrated using SRTM and TOPSAR data for 15 red pine and Austrian pine stands (TOPSAR is an airborne interferometric synthetic aperture radar). The algorithm yields root-mean-square (rms) errors of 2.5-3.6 m, which is a substantial improvement over the 6.8-8.3-m rms errors from the raw SRTM minus National Elevation Dataset Heights.

  8. A new molecular model for Congo Red-β amyloid interaction: implications for diagnosis and inhibition of brain plaque formation in Alzheimer's disease

    Science.gov (United States)

    Zhang, Kristine A.; Li, Yat

    2015-08-01

    Alzheimer's disease (AD), an age-related neurodegenerative disorder, is the seventh leading cause of death in the United States. One strong pathological indicator of AD is senile plaques, which are aggregates of fibrils formed from amyloid β (Aβ) peptides. Thus, detection and inhibition of Aβ aggregation are critical for the prevention and treatment of AD. Congo red (CR) is one of the most widely used dye molecules for probing as well as inhabiting Aβ aggregation. However, the nature of interaction between CR and Aβ is not well understood. In this research, we systematically studied the interaction between CR and Aβ using a combination of optical techniques, including electronic absorption, fluorescence, Raman scattering, and circular dichroism, to provide detailed information with molecular specificity and high sensitivity. Compared to CR alone, interaction of the dye with Aβ results in a new absorption peak near 540 nm and significantly enhanced photoluminescence as well as Raman signal. Our results led us to propose a new model suggesting that CR exists primarily in a micellar form, resembling H-aggregates, in water and dissociates into monomers upon interaction with Aβ. This model has significant implications for the development of new strategies to detect and inhibit brain plaques for treatment of neurological diseases like AD.

  9. King penguin population on Macquarie Island recovers ancient DNA diversity after heavy exploitation in historic times.

    Science.gov (United States)

    Heupink, Tim H; van den Hoff, John; Lambert, David M

    2012-08-23

    Historically, king penguin populations on Macquarie Island have suffered greatly from human exploitation. Two large colonies on the island were drastically reduced to a single small colony as a result of harvesting for the blubber oil industry. However, recent conservation efforts have resulted in the king penguin population expanding in numbers and range to recolonize previous as well as new sites. Ancient DNA methods were used to estimate past genetic diversity and combined with studies of modern populations, we are now able to compare past levels of variation with extant populations on northern Macquarie Island. The ancient and modern populations are closely related and show a similar level of genetic diversity. These results suggest that the king penguin population has recovered past genetic diversity in just 80 years owing to conservation efforts, despite having seen the brink of extinction.

  10. Five analogies between a King's Speech treatment and contemporary play therapies.

    Science.gov (United States)

    Terr, Lenore C

    2012-01-01

    Psychiatric patients frequently respond positively to play therapy, which may rely on psychoanalytic, Jungian, cognitive-behavioral, familial, school-based, or other theories. I wished to determine if there were unifying principles that tie together these various types of play treatments. The fact-based film, The King's Speech, vividly illustrates play utilized by Lionel Logue in his speech treatment (1926-1939) of the future King of England. In the film I found five analogies to the play therapy I employ in office practice. The play scenes in The King's Speech point to five unifying principles among contemporary play therapies: (1) the crucial nature of the relationship, (2) the centrality of having fun, (3) the occasional reliance on others, (4) the interjection of pithy talk, and (5) the usefulness of a little drama. No matter what theory a play therapist ascribes to, these five unifying principles should be kept in mind during treatment.

  11. Archeology in Medicine: Digging up into the tophi of Popes, Dukes and Kings

    Directory of Open Access Journals (Sweden)

    G. Ceccarelli

    2011-09-01

    Full Text Available According to an Anglo-Saxon pun, “gout is the king of diseases and the disease of Kings”. In fact, it is well-known that in past times a quantity of famous persons, including Kings and Popes, were affected with this rheumatic disorder. In this paper biographical anecdotes on several Popes (Pius III, Julius II, Julius III, Clement VIII, Innocent XI, Clement XII and Pius VIII, King George IV and Queen Anne of England, as well as on some members of the Lorraine lineage, all suffering from gout, are sketched out. These historical data are briefly discussed in relation to the celebrated Hippocrates’s aphorisms on gout.

  12. Fifth Annual Report: 2008 Pre-Construction Eelgrass Monitoring and Propagation for King County Outfall Mitigation

    Energy Technology Data Exchange (ETDEWEB)

    Woodruff, Dana L.; Judd, Chaeli; Thom, Ronald M.; Sather, Nichole K.; Kaufmann, Ronald M.

    2010-01-01

    This is the fifth and final report in a series documenting progress of the pre-construction eelgrass restoration and mitigation activities for the proposed King County Brightwater marine outfall, discharging to Puget Sound near Point Wells, Washington. King County began implementing a multiyear eelgrass monitoring and restoration program in 2004, with the primary goal of returning intertidal and shallow subtidal habitat and eelgrass to pre-construction conditions, after construction of the outfall. Major eelgrass mitigation program elements include: a) pre-construction monitoring, i.e., documenting initial eelgrass conditions and degree of fluctuation over a 5 year period prior to construction, b) eelgrass transplanting, including harvesting, offsite propagation and stockpiling of local plants for post-construction planting, and c) post-construction planting and subsequent monitoring, occurring in 2009 and beyond. The overall program is detailed in the Eelgrass Restoration and Biological Resources Implementation Workplan (King County 2008).

  13. King George Island ice cap geometry updated with airborne GPR measurements

    Directory of Open Access Journals (Sweden)

    M. Rückamp

    2012-07-01

    Full Text Available Ice geometry is a mandatory requirement for numerical modelling purposes. In this paper we present a consistent data set for the ice thickness, the bedrock topography and the ice surface topography of the King George Island ice cap (Arctowski icefield and the adjacent central part. The new data set is composed of ground based and airborne ground penetrating radar (GPR and differential GPS (DGPS measurements, obtained during several field campaigns. Blindow et al. (2010 already provided a comprehensive overview of the ground based measurements carried out in the safely accessible area of the ice cap. The updated data set incorporates airborne measurements in the heavily crevassed coastal areas. Therefore, in this paper special attention is paid to the airborne measurements by addressing the instrument used, survey procedure, and data processing in more detail. In particular, the inclusion of airborne GPR measurements with the 30 MHz BGR-P30-System developed at the Institute of Geophysics (University of Münster completes the picture of the ice geometry substantially. The compiled digital elevation model of the bedrock shows a rough, highly variable topography with pronounced valleys, ridges, and troughs. Mean ice thickness is 240 ± 6 m, with a maximum value of 422 ± 10 m in the surveyed area. Noticeable are bounded areas in the bedrock topography below sea level where marine based ice exists. The provided data set is required as a basis for future monitoring attempts or as input for numerical modelling experiments. The data set is available from the PANGAEA database at http://dx.doi.org/10.1594/PANGAEA.770567.

  14. Red and Green Fluorescence from Oral Biofilms.

    Science.gov (United States)

    Volgenant, Catherine M C; Hoogenkamp, Michel A; Krom, Bastiaan P; Janus, Marleen M; Ten Cate, Jacob M; de Soet, Johannes J; Crielaard, Wim; van der Veen, Monique H

    2016-01-01

    Red and green autofluorescence have been observed from dental plaque after excitation by blue light. It has been suggested that this red fluorescence is related to caries and the cariogenic potential of dental plaque. Recently, it was suggested that red fluorescence may be related to gingivitis. Little is known about green fluorescence from biofilms. Therefore, we assessed the dynamics of red and green fluorescence in real-time during biofilm formation. In addition, the fluorescence patterns of biofilm formed from saliva of eight different donors are described under simulated gingivitis and caries conditions. Biofilm formation was analysed for 12 hours under flow conditions in a microfluidic BioFlux flow system with high performance microscopy using a camera to allow live cell imaging. For fluorescence images dedicated excitation and emission filters were used. Both green and red fluorescence were linearly related with the total biomass of the biofilms. All biofilms displayed to some extent green and red fluorescence, with higher red and green fluorescence intensities from biofilms grown in the presence of serum (gingivitis simulation) as compared to the sucrose grown biofilms (cariogenic simulation). Remarkably, cocci with long chain lengths, presumably streptococci, were observed in the biofilms. Green and red fluorescence were not found homogeneously distributed within the biofilms: highly fluorescent spots (both green and red) were visible throughout the biomass. An increase in red fluorescence from the in vitro biofilms appeared to be related to the clinical inflammatory response of the respective saliva donors, which was previously assessed during an in vivo period of performing no-oral hygiene. The BioFlux model proved to be a reliable model to assess biofilm fluorescence. With this model, a prediction can be made whether a patient will be prone to the development of gingivitis or caries.

  15. Red and Green Fluorescence from Oral Biofilms.

    Directory of Open Access Journals (Sweden)

    Catherine M C Volgenant

    Full Text Available Red and green autofluorescence have been observed from dental plaque after excitation by blue light. It has been suggested that this red fluorescence is related to caries and the cariogenic potential of dental plaque. Recently, it was suggested that red fluorescence may be related to gingivitis. Little is known about green fluorescence from biofilms. Therefore, we assessed the dynamics of red and green fluorescence in real-time during biofilm formation. In addition, the fluorescence patterns of biofilm formed from saliva of eight different donors are described under simulated gingivitis and caries conditions. Biofilm formation was analysed for 12 hours under flow conditions in a microfluidic BioFlux flow system with high performance microscopy using a camera to allow live cell imaging. For fluorescence images dedicated excitation and emission filters were used. Both green and red fluorescence were linearly related with the total biomass of the biofilms. All biofilms displayed to some extent green and red fluorescence, with higher red and green fluorescence intensities from biofilms grown in the presence of serum (gingivitis simulation as compared to the sucrose grown biofilms (cariogenic simulation. Remarkably, cocci with long chain lengths, presumably streptococci, were observed in the biofilms. Green and red fluorescence were not found homogeneously distributed within the biofilms: highly fluorescent spots (both green and red were visible throughout the biomass. An increase in red fluorescence from the in vitro biofilms appeared to be related to the clinical inflammatory response of the respective saliva donors, which was previously assessed during an in vivo period of performing no-oral hygiene. The BioFlux model proved to be a reliable model to assess biofilm fluorescence. With this model, a prediction can be made whether a patient will be prone to the development of gingivitis or caries.

  16. Laboratory model of the potential role of fungi (Phytophthora spp. ) in the decomposition of red mangrove (Rhizophora mangle) leaf litter

    Energy Technology Data Exchange (ETDEWEB)

    Fell, J.W.; Master, I.M.; Newell, S.Y.

    1977-01-01

    Field studies of quantitative changes in carbon, nitrogen and dry weight of decomposing mangrove leaves demonstrated similar net weight and carbon losses irrespective of station location or time of year. In contrast, rates differed and percent change in nitrogen content varied from no gain to 78% increase. A laboratory model was designed to examine the field responses. Because of variation between leaves, a split leaf technique was developed in which one half of the leaf was used to predict the original carbon, nitrogen and dry weight of the other, experimental, half leaf. Nitrogen immobilization, in the laboratory studies, required the presence of microorganisms, such as fungi of the genus Phytophthora, and the addition of inorganic N. The final amount of nitrogen in the leaf was directly related to the original amount, however, change in nitrogen was inversely related to original nitrogen. Weight loss was inversely related to the dry weight:fresh weight ratio of the leaves, possibly due to the high fiber content of the high ratio leaves. A discussion is presented of the field results, as interpreted by the laboratory model. 28 references, 15 figures, 1 table.

  17. Proof of the mysterious efficacy of ginseng: basic and clinical trials: effects of red ginseng on learning and memory deficits in an animal model of amnesia.

    Science.gov (United States)

    Nishijo, Hisao; Uwano, Teruko; Zhong, Yong-Mei; Ono, Taketoshi

    2004-06-01

    Ameliorating effects of red ginseng on learning and memory deficits due to hippocampal lesions and aging were reviewed; the performance of young rats with selective hippocampal lesions with or without red ginseng (p.o.), and aged rats with or without red ginseng (p.o.) in the spatial learning tasks was compared with that of sham-operated or intact young rats. Each rat was tested with 3 types of spatial learning tasks (distance movement task, DMT; random reward place search task, RRPST; and place learning task, PLT) in a circular open field using intracranial self-stimulation (ICSS) as reward. The results in the DMT and RRPST indicated that motivational and motor activity of young rats with hippocampal lesions with and without ginseng and aged rats with and without ginseng were not significantly different from that of control young rats. However, young rats with hippocampal lesions without ginseng and aged rats without ginseng displayed significant deficits in the PLT. Treatment with red ginseng significantly ameliorated place-navigation deficits in young rats with hippocampal lesions in the PLT. Similarly, red ginseng improved performance of aged rats in the PLT. The results, along with previous studies showing significant effects of red ginseng on the central nervous system, suggest that red ginseng ameliorates learning and memory deficits through effects on the central nervous system, partly through effects on the hippocampal formation. However, its mechanisms are still unclear, and further studies are required.

  18. Towards PDT with Genetically Encoded Photosensitizer KillerRed: A Comparison of Continuous and Pulsed Laser Regimens in an Animal Tumor Model.

    Directory of Open Access Journals (Sweden)

    Marina Shirmanova

    Full Text Available The strong phototoxicity of the red fluorescent protein KillerRed allows it to be considered as a potential genetically encoded photosensitizer for the photodynamic therapy (PDT of cancer. The advantages of KillerRed over chemical photosensitizers are its expression in tumor cells transduced with the appropriate gene and direct killing of cells through precise damage to any desired cell compartment. The ability of KillerRed to affect cell division and to induce cell death has already been demonstrated in cancer cell lines in vitro and HeLa tumor xenografts in vivo. However, the further development of this approach for PDT requires optimization of the method of treatment. In this study we tested the continuous wave (593 nm and pulsed laser (584 nm, 10 Hz, 18 ns modes to achieve an antitumor effect. The research was implemented on CT26 subcutaneous mouse tumors expressing KillerRed in fusion with histone H2B. The results showed that the pulsed mode provided a higher rate of photobleaching of KillerRed without any temperature increase on the tumor surface. PDT with the continuous wave laser was ineffective against CT26 tumors in mice, whereas the pulsed laser induced pronounced histopathological changes and inhibition of tumor growth. Therefore, we selected an effective regimen for PDT when using the genetically encoded photosensitizer KillerRed and pulsed laser irradiation.

  19. The influence of the king on medical practice in ancient Mesopotamia.

    Science.gov (United States)

    Adamson, P B

    1989-01-01

    Rulers in ancient Mesopotamia were interested in their own health and, by the second millenium B.C., medicine was extended to the population, but not to the conquered people. Physicians were very few and under patronage and control of the king; they were a cast lower than priests and considered as skilled technicians, with a great influence. Surgeons and veterinary surgeons were also encouraged, but kings promulgated laws to reward and penalise surgeons for damage or trauma or failure to effect a cure of the patients, heritage of the lex talionis.

  20. AFSC/RACE/SAP/Swiney: Effects of holding space on juvenile red king crab growth and survival

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Rearing crustaceans communally for aquaculture, stock enhancement or research often results in high rates of cannibalism and low yields. One potential strategy to...

  1. AFSC/RACE/SAP/Swiney: Effects of ocean acidification and increased temperatures on juvenile red king crab

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Multiple stressor studies are needed to better understand the effects of oceanic changes on marine organisms. To determine the effects of near-future ocean...

  2. Matrix Metalloproteinases Are Differentially Regulated and Responsive to Compression Therapy in a Red Duroc Model of Hypertrophic Scar.

    Science.gov (United States)

    Travis, Taryn E; Ghassemi, Pejhman; Prindeze, Nicholas J; Moffatt, Lauren T; Carney, Bonnie C; Alkhalil, Abdulnaser; Ramella-Roman, Jessica C; Shupp, Jeffrey W

    2018-01-01

    Objective: Proteins of the matrix metalloproteinases family play a vital role in extracellular matrix maintenance and basic physiological processes in tissue homeostasis. The function and activities of matrix metalloproteinases in response to compression therapies have yet to be defined. Here, a swine model of hypertrophic scar was used to profile the transcription of all known 26 matrix metalloproteinases in scars treated with a precise compression dose. Methods: Full-thickness excisional wounds were created. Wounds underwent healing and scar formation. A subset of scars underwent 2 weeks of compression therapy. Biopsy specimens were preserved, and microarrays, reverse transcription-polymerase chain reaction, Western blotting, and immunohistochemistry were performed to characterize the transcription and expression of various matrix metalloproteinase family members. Results: Microarray results showed that 13 of the known 26 matrix metalloproteinases were differentially transcribed in wounds relative to the preinjury skin. The predominant upregulation of these matrix metalloproteinases during early wound-healing stages declined gradually in later stages of wound healing. The use of compression therapy reduced this decline in 10 of the 13 differentially regulated matrix metalloproteinases. Further investigation of MMP7 using reverse transcription-polymerase chain reaction confirmed the effect of compression on transcript levels. Assessment of MMP7 at the protein level using Western blotting and immunohistochemistry was concordant. Conclusions: In a swine model of hypertrophic scar, the application of compression to hypertrophic scar attenuated a trend of decreasing levels of matrix metalloproteinases during the process of hypertrophic wound healing, including MMP7, whose enzyme regulation was confirmed at the protein level.

  3. Escaping from allegories:cat’s eye and King Lear Escaping from allegories:cat’s eye and King Lear

    Directory of Open Access Journals (Sweden)

    Caroline Cakebread

    2008-04-01

    Full Text Available In her 1972 study of Canadian literature, aptly titled Survival, Margaret Atwood uses the symbol of the mirror to describe the difficulty faced by Canadian writers and artists, struggling to assert their voices in a country trying to define itself against a colonial past.Here, she sees Canada as squeezed between the overwhelming, colonizing powers of Great Britain on one side, and The United States on the other. In her view, a piece of art becomes a mirror. As she writes: If a country or a culture lacks such mirrors it has no way of knowing what it looks like; it must travel blind. If, as has long been the case in [Canada], the viewer is given a mirror that reflects not him but someone else, and told at the same time that the reflection he sees is himself, he will get a very distorted idea of what he is really like. He will also get a distorted idea of what other people are like: it’s hard to find out who anyone else is until you have found out who you are. (15-16 With its roots in Lacanian psychoanalysis, the mirror Atwood describes provides an unreliable reflection for burgeoning artists inCanada: up against the powerful countries that surround them she sees a major identity crisis. Sixteen years later, her 1988 novel, Cat’s Eye, treads similar ground, tracking as it does the passage of its protagonist—painter, Elaine Risley—through childhood in mid-century Canada to her development as an established artist in the 1980s. It is into this narrative that Atwood places extensive references to Shakespeare’s tragedy, King Lear—a play that deals with the notion of identity. Here, Lear’s question, “Who is it that can tell me who I am?” becomes Elaine’s, as she ventures back to Toronto to attend a retrospective of her work at a women’s art gallery named “Sub-Versions.” In her 1972 study of Canadian literature, aptly titled Survival, Margaret Atwood uses the symbol of the mirror to describe the difficulty faced

  4. 75 FR 52511 - North Pacific Fishery Management Council; Notice of Public Meeting

    Science.gov (United States)

    2010-08-26

    ...; review Bristol Bay red king crab CIE report, review and recommend approaches for Tanner crab model, review and recommend approaches for Pribilof Islands blue king crab and red king crab models, receive an...: results of the 2010 survey; snow crab spatial model and management strategy evaluation projects; discuss...

  5. Calibration of a water-quality model for low-flow conditions on the Red River of the North at Fargo, North Dakota, and Moorhead, Minnesota, 2003

    Science.gov (United States)

    Lundgren, Robert F.; Nustad, Rochelle A.

    2008-01-01

    A time-of-travel and reaeration-rate study was conducted by the U.S. Geological Survey, in cooperation with the North Dakota Department of Health, the Minnesota Pollution Control Agency, and the cities of Fargo, North Dakota, and Moorhead, Minnesota, to provide information to calibrate a water-quality model for streamflows of less than 150 cubic feet per second. Data collected from September 24 through 27, 2003, were used to develop and calibrate the U.S. Environmental Protection Agency Water Quality Analysis Simulation Program model (hereinafter referred to as the Fargo WASP water-quality model) for a 19.2-mile reach of the Red River of the North. The Fargo WASP water-quality model was calibrated for the transport of dye by fitting simulated time-concentration dye curves to measured time-concentration dye curves. Simulated peak concentrations were within 10 percent of measured concentrations. Simulated traveltimes of the dye cloud centroid were within 7 percent of measured traveltimes. The variances of the simulated dye concentrations were similar to the variances of the measured dye concentrations, indicating dispersion was reproduced reasonably well. Average simulated dissolved-oxygen concentrations were within 6 percent of average measured concentrations. Average simulated ammonia concentrations were within the range of measured concentrations. Simulated dissolved-oxygen and ammonia concentrations were affected by the specification of a single nitrification rate in the Fargo WASP water-quality model. Data sets from August 1989 and August 1990 were used to test traveltime and simulation of dissolved oxygen and ammonia. For streamflows that ranged from 60 to 407 cubic feet per second, simulated traveltimes were within 7 percent of measured traveltimes. Measured dissolved-oxygen concentrations were underpredicted by less than 15 percent for both data sets. Results for ammonia were poor; measured ammonia concentrations were underpredicted by as much as 70 percent

  6. Multi-scale biomarker evaluation of the toxicity of a commercial azo dye (Disperse Red 1) in an animal model, the freshwater cnidarian Hydra attenuata.

    Science.gov (United States)

    de Jong, Laetitia; Pech, Nicolas; de Aragão Umbuzeiro, Gisela; Moreau, Xavier

    2016-06-01

    Acute (24 h, 48 h, 72 h) and chronic (7 days) tests have been performed to evaluate the effects of the commercial azo dye Disperse Red 1 (DR1) using various biomarkers in the freshwater invertebrate Hydra attenuata. Morphological changes have been selected to calculate ecotoxicological thresholds for sublethal and lethal DR1 concentrations. A multinomial logistic model showed that the probability of each morphological stage occurrence was function of concentration, time and interaction between both. Results of oxidative balance parameter measurements (72 h and 7 days) suggest that polyps set up defense mechanisms to limit lipid peroxidation caused by DR1. DR1 exposure at hormetic concentrations induces increase of asexual reproductive rates. This result suggests (1) an impact on the fitness-related phenotypical traits and (2) trade-offs between reproduction and maintenance to allow the population to survive harsher conditions. Changes in serotonin immuno-labeling in polyps showing alterations in feeding behavior suggest that chronic DR1 exposure impaired neuronal processes related to ingesting behavior in H. attenuata. This ecotoxicity study sheds light on the possible serotonin function in Hydra model and reports for the first time that serotonin could play a significant role in feeding behavior. This study used a multi-scale biomarker approach investigating biochemical, morphological, reproductive and behavioral endpoints in Hydra attenuata. This organism is proposed for a pertinent animal model to assess ecotoxicological impact of pollutant mixtures in freshwater environment. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. From red giants to planetary nebulae

    International Nuclear Information System (INIS)

    Kwok, S.

    1982-01-01

    The transition from red giants to planetary nebulae is studied by comparing the spectral characteristics of red giant envelopes and planetary nebulae. Observational and theoretical evidence both suggest that remnants of red giant envelopes may still be present in planetary nebula systems and should have significant effects on their formation. The dynamical effects of the interaction of stellar winds from central stars of planetary nebulae with the remnant red giant envelopes are evaluated and the mechanism found to be capable of producing the observed masses and momenta of planetary nebulae. The observed mass-radii relation of planetary nebulae may also be best explained by the interacting winds model. The possibility that red giant mass loss, and therefore the production of planetary nebulae, is different between Population I and II systems is also discussed

  8. Estimating the spatial and temporal distribution of species richness within Sequoia and Kings Canyon National Parks.

    Science.gov (United States)

    Wathen, Steve; Thorne, James H; Holguin, Andrew; Schwartz, Mark W

    2014-01-01

    Evidence for significant losses of species richness or biodiversity, even within protected natural areas, is mounting. Managers are increasingly being asked to monitor biodiversity, yet estimating biodiversity is often prohibitively expensive. As a cost-effective option, we estimated the spatial and temporal distribution of species richness for four taxonomic groups (birds, mammals, herpetofauna (reptiles and amphibians), and plants) within Sequoia and Kings Canyon National Parks using only existing biological studies undertaken within the Parks and the Parks' long-term wildlife observation database. We used a rarefaction approach to model species richness for the four taxonomic groups and analyzed those groups by habitat type, elevation zone, and time period. We then mapped the spatial distributions of species richness values for the four taxonomic groups, as well as total species richness, for the Parks. We also estimated changes in species richness for birds, mammals, and herpetofauna since 1980. The modeled patterns of species richness either peaked at mid elevations (mammals, plants, and total species richness) or declined consistently with increasing elevation (herpetofauna and birds). Plants reached maximum species richness values at much higher elevations than did vertebrate taxa, and non-flying mammals reached maximum species richness values at higher elevations than did birds. Alpine plant communities, including sagebrush, had higher species richness values than did subalpine plant communities located below them in elevation. These results are supported by other papers published in the scientific literature. Perhaps reflecting climate change: birds and herpetofauna displayed declines in species richness since 1980 at low and middle elevations and mammals displayed declines in species richness since 1980 at all elevations.

  9. Estimating the spatial and temporal distribution of species richness within Sequoia and Kings Canyon National Parks.

    Directory of Open Access Journals (Sweden)

    Steve Wathen

    Full Text Available Evidence for significant losses of species richness or biodiversity, even within protected natural areas, is mounting. Managers are increasingly being asked to monitor biodiversity, yet estimating biodiversity is often prohibitively expensive. As a cost-effective option, we estimated the spatial and temporal distribution of species richness for four taxonomic groups (birds, mammals, herpetofauna (reptiles and amphibians, and plants within Sequoia and Kings Canyon National Parks using only existing biological studies undertaken within the Parks and the Parks' long-term wildlife observation database. We used a rarefaction approach to model species richness for the four taxonomic groups and analyzed those groups by habitat type, elevation zone, and time period. We then mapped the spatial distributions of species richness values for the four taxonomic groups, as well as total species richness, for the Parks. We also estimated changes in species richness for birds, mammals, and herpetofauna since 1980. The modeled patterns of species richness either peaked at mid elevations (mammals, plants, and total species richness or declined consistently with increasing elevation (herpetofauna and birds. Plants reached maximum species richness values at much higher elevations than did vertebrate taxa, and non-flying mammals reached maximum species richness values at higher elevations than did birds. Alpine plant communities, including sagebrush, had higher species richness values than did subalpine plant communities located below them in elevation. These results are supported by other papers published in the scientific literature. Perhaps reflecting climate change: birds and herpetofauna displayed declines in species richness since 1980 at low and middle elevations and mammals displayed declines in species richness since 1980 at all elevations.

  10. Diltiazem Reduces Mortality and Breakdown of ATP in Red Blood Cell Induced by Isoproterenol in a Freely Moving Rat Model in Vivo

    Directory of Open Access Journals (Sweden)

    Pollen K.F. Yeung

    2014-09-01

    Full Text Available The benefit of calcium channel blockers for cardiovascular prevention against heart attack and stroke has not been firmly supported. We investigated the possible cardiovascular protective effect of diltiazem (DTZ against injury induced by isoproterenol using a freely moving rat model in vivo. Sprague Dawley rats were injected subcutaneously (sc with either 5 or 10 mg/kg of DTZ, or saline as control, twice daily for five doses. One hour after the last injection, a single dose of isoproterenol (30 mg/kg was injected sc to each rat. Blood samples were collected serially for 6 h for measurement of adenine nucleotides (ATP, ADP and AMP in red blood cell (RBC by a validated HPLC. The study has shown isoproterenol induced 50% mortality and also increased RBC concentrations of AMP from 0.04 ± 0.02 to 0.29 ± 0.21 mM at the end of the experiment (p < 0.05. Treatment with 10 mg/kg of DTZ reduced mortality from 50% to <20% and attenuated the increase of RBC concentrations of AMP from +0.25 ± 0.22 in the control rats to +0.072 ± 0.092 mM (p < 0.05. The study concluded that 10 mg/kg of DTZ reduced mortality and breakdown of ATP induced by isoproterenol in rats.

  11. Red Deer Antler Extract Accelerates Hair Growth by Stimulating Expression of Insulin-like Growth Factor I in Full-thickness Wound Healing Rat Model.

    Science.gov (United States)

    Yang, ZhiHong; Gu, LiJuan; Zhang, DongLiang; Li, Zheng; Li, JingJie; Lee, MiRa; Wang, ChunYan; Wang, Zhen; Cho, JeongHee; Sung, Changkeun

    2012-05-01

    In order to investigate and evaluate the effects of red deer antlers on hair growth in the full-thickness wound healing model, Sprague-Dawley rats were given incision wounds through the full thickness of their dorsal skin and deer antler was applied for 40 days. At specified intervals thereafter (4, 8, 16, 32 and 40 days), the animals were sacrificed and the wound site skins were excised, processed, and sectioned. At post-injury days 16, 32 and 40, longer and more active new hair appeared around the healing wound of antler-treated skin. Histological studies showed that the antler extract markedly increases the depth, size, and number of hair follicles. Expression of IGF-I (insulin-like growth factor) mRNA was detected by RT-PCR and real time RT-PCR. The result showed that the expression of IGF-I (days 16, 32, and 40) was obviously up-regulated in antler-treated skins compared to control skins. Similar results were seen in the ELISA analysis to quantify the IGF-I expression. These results support the notion that wound healing can cause hair growth by enhancing the expression of IGF-I. Deer antler extract appears to have the potential to promote hair growth and could be used in hair growth products.

  12. Effects of Korean red ginseng extract on the prevention of atopic dermatitis and its mechanism on early lesions in a murine model.

    Science.gov (United States)

    Cho, Eujin; Cho, Sang Hyun

    2013-01-09

    Korean red ginseng (KRG) has been shown to possess various biological activities including anti-inflammatory properties. We aimed to investigate the effects and mechanism of KRG on the prevention of atopic dermatitis (AD) using a mouse model. The effect of KRG in trinitrochlorobenzene (TNCB)-treated NC/Nga mice was assessed by measuring ear thickness, transepidermal water loss (TEWL), total serum IgE, histologic changes of lesional skin, mRNA and protein expression of thymic stromal lymphopoietin (TSLP) and tumor necrosis factor (TNF)-α, immunohistochemistry for tissue interleukin (IL)-4, IL-17, and interferon (IFN)-γ. KRG significantly reduced ear thickness. Oral administration of KRG significantly prevented the increase in TEWL induced by TNCB. The serum IgE level was significantly lower in the KRG group. Histologically, lymphocyte infiltration was markedly decreased by KRG. CD1a positive (CD1a+) cells were diminished by KRG. Immunohistochemically, KRG significantly suppressed the protein expression of TSLP and TNF-α. The mRNA expression of TSLP in the lesions was significantly reduced by KRG. These results demonstrate that oral administration of KRG may inhibit the development of AD-like skin lesions in NC/Nga mice by modifying TSLP, DCs, and at least in part, the Th2 response. KRG may be a potential therapeutic modality for the prevention of AD. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  13. Red Deer Antler Extract Accelerates Hair Growth by Stimulating Expression of Insulin-like Growth Factor I in Full-thickness Wound Healing Rat Model

    Directory of Open Access Journals (Sweden)

    ZhiHong Yang

    2012-05-01

    Full Text Available In order to investigate and evaluate the effects of red deer antlers on hair growth in the full-thickness wound healing model, Sprague-Dawley rats were given incision wounds through the full thickness of their dorsal skin and deer antler was applied for 40 days. At specified intervals thereafter (4, 8, 16, 32 and 40 days, the animals were sacrificed and the wound site skins were excised, processed, and sectioned. At post-injury days 16, 32 and 40, longer and more active new hair appeared around the healing wound of antler-treated skin. Histological studies showed that the antler extract markedly increases the depth, size, and number of hair follicles. Expression of IGF-I (insulin-like growth factor mRNA was detected by RT-PCR and real time RT-PCR. The result showed that the expression of IGF-I (days 16, 32, and 40 was obviously up-regulated in antler-treated skins compared to control skins. Similar results were seen in the ELISA analysis to quantify the IGF-I expression. These results support the notion that wound healing can cause hair growth by enhancing the expression of IGF-I. Deer antler extract appears to have the potential to promote hair growth and could be used in hair growth products.

  14. Inquiring into Red/Red Inquiring

    Directory of Open Access Journals (Sweden)

    Ken Gale

    2013-05-01

    Full Text Available This layered account of an inquiry into ‘red’ emerged out of a collective biography workshop. In the middle of the Wiltshire countryside, an international and interdisciplinary group of scholars gathered together to write and make other things and marks on paper that asked questions of, and into, the spaces between words, people, things and their environments. We did not set out to workshop or write into or paint ‘red’ but, rather, it was red that slipped in, uninvited, and painted and wrote us. Red arose as a blush or a stain seeping amongst us that became referenced obliquely by material objects, metaphors and fairytales. The stain spread, became noticeable through our weekend together and beyond it, creating another (bright red artery vein of connection to write with.

  15. King post truss as a motif for internal structure of (meta)material with controlled elastic properties

    Science.gov (United States)

    Turco, Emilio; Giorgio, Ivan; Misra, Anil; dell'Isola, Francesco

    2017-10-01

    One of the most interesting challenges in the modern theory of materials consists in the determination of those microstructures which produce, at the macro-level, a class of metamaterials whose elastic range is many orders of magnitude wider than the one exhibited by `standard' materials. In dell'Isola et al. (2015 Zeitschrift für angewandte Mathematik und Physik 66, 3473-3498. (doi:10.1007/s00033-015-0556-4)), it was proved that, with a pantographic microstructure constituted by `long' micro-beams it is possible to obtain metamaterials whose elastic range spans up to an elongation exceeding 30%. In this paper, we demonstrate that the same behaviour can be obtained by means of an internal microstructure based on a king post motif. This solution shows many advantages: it involves only microbeams; all constituting beams are undergoing only extension or compression; all internal constraints are terminal pivots. While the elastic deformation energy can be determined as easily as in the case of long-beam microstructure, the proposed design seems to have obvious remarkable advantages: it seems to be more damage resistant and therefore to be able to have a wider elastic range; it can be realized with the same three-dimensional printing technology; it seems to be less subject to compression buckling. The analysis which we present here includes: (i) the determination of Hencky-type discrete models for king post trusses, (ii) the application of an effective integration scheme to a class of relevant deformation tests for the proposed metamaterial and (iii) the numerical determination of an equivalent second gradient continuum model. The numerical tools which we have developed and which are presented here can be readily used to develop an extensive measurement campaign for the proposed metamaterial.

  16. Activation of Wnt/β-catenin signaling is involved in hair growth-promoting effect of 655-nm red light and LED in in vitro culture model.

    Science.gov (United States)

    Han, Le; Liu, Ben; Chen, Xianyan; Chen, Haiyan; Deng, Wenjia; Yang, Changsheng; Ji, Bin; Wan, Miaojian

    2018-04-01

    Activation of the Wnt/β-catenin signaling pathway plays an important role in hair follicle morphogenesis and hair growth. Recently, low-level laser therapy (LLLT) was evaluated for stimulating hair growth in numerous clinical studies, in which 655-nm red light was found to be most effective and practical for stimulating hair growth. We evaluated whether 655-nm red light + light-emitting diode (LED) could promote human hair growth by activating Wnt/β-catenin signaling. An in vitro culture of human hair follicles (HFs) was irradiated with different intensities of 655-nm red light + LED, 21 h7 (an inhibitor of β-catenin), or both. Immunofluorescence staining was performed to assess the expression of β-catenin, GSK3β, p-GSK3β, and Lef1 in the Wnt/β-catenin signaling. The 655-nm red light + LED not only enhanced hair shaft elongation, but also reduced catagen transition in human hair follicle organ culture, with the greatest effectiveness observed at 5 min (0.839 J/cm 2 ). Additionally, 655-nm red light + LED enhanced the expression of β-catenin, p-GSK3β, and Lef1, signaling molecules of the Wnt/β-catenin pathway, in the hair matrix. Activation of Wnt/β-catenin signaling is involved in hair growth-promoting effect of 655-nm red light and LED in vitro and therefore may serve as an alternative therapeutic option for alopecia.

  17. Intravenous injection of artificial red cells and subsequent dye laser irradiation causes deep vessel impairment in an animal model of port-wine stain.

    Science.gov (United States)

    Rikihisa, Naoaki; Tominaga, Mai; Watanabe, Shoji; Mitsukawa, Nobuyuki; Saito, Yoshiaki; Sakai, Hiromi

    2018-03-15

    Our previous study proposed using artificial blood cells (hemoglobin vesicles, Hb-Vs) as photosensitizers in dye laser treatment for port-wine stains (PWSs). Dye laser photons are absorbed by red blood cells (RBCs) and hemoglobin (Hb) mixture, which potentially produce more heat and photocoagulation and effectively destroy endothelial cells. Hb-Vs combination therapy will improve clinical outcomes of dye laser treatment for PWSs because very small vessels do not contain sufficient RBCs and they are poor absorbers/heaters of lasers. In the present study, we analyzed the relationship between vessel depth from the skin surface and vessel distraction through dye laser irradiation following intravenous Hb-Vs injection using a chicken wattle model. Hb-Vs were administered and chicken wattles underwent high-energy irradiation at energy higher than in the previous experiments. Hb-Vs location in the vessel lumen was identified to explain its photosensitizer effect using human Hb immunostaining of the irradiated wattles. Laser irradiation with Hb-Vs can effectively destroy deep vessels in animal models. Hb-Vs tend to flow in the marginal zone of both small and large vessels. Increasing laser power combined with Hb-Vs injection contributed for deep vessel impairment because of the synergetic effect of both methods. Newly added Hb tended to flow near the target endothelial cells of the laser treatment. In Hb-Vs and RBC mixture, heat transfer to endothelial cells from absorbers/heater may increase. Hb-Vs function as photosensitizers to destroy deep vessels within a restricted distance that the photon can reach.

  18. Biofortified red mottled beans (Phaseolus vulgaris L. in a maize and bean diet provide more bioavailable iron than standard red mottled beans: Studies in poultry (Gallus gallus and an in vitro digestion/Caco-2 model

    Directory of Open Access Journals (Sweden)

    Glahn Raymond P

    2011-10-01

    Full Text Available Abstract Background Our objective was to compare the capacities of biofortified and standard colored beans to deliver iron (Fe for hemoglobin synthesis. Two isolines of large-seeded, red mottled Andean beans (Phaseolus vulgaris L., one standard ("Low Fe" and the other biofortified ("High Fe" in Fe (49 and 71 μg Fe/g, respectively were used. This commercial class of red mottled beans is the preferred varietal type for most of the Caribbean and Eastern and Southern Africa where almost three quarters of a million hectares are grown. Therefore it is important to know the affect of biofortification of these beans on diets that simulate human feeding studies. Methods Maize-based diets containing the beans were formulated to meet the nutrient requirements for broiler except for Fe (Fe concentrations in the 2 diets were 42.9 ± 1.2 and 54.6 ± 0.9 mg/kg. One day old chicks (Gallus gallus were allocated to the experimental diets (n = 12. For 4 wk, hemoglobin, feed-consumption and body-weights were measured. Results Hemoglobin maintenance efficiencies (HME (means ± SEM were different between groups on days 14 and 21 of the experiment (P In-vitro analysis showed lower iron bioavailability in cells exposed to standard ("Low Fe" bean based diet. Conclusions We conclude that the in-vivo results support the in-vitro observations; biofortified colored beans contain more bioavailable-iron than standard colored beans. In addition, biofortified beans seems to be a promising vehicle for increasing intakes of bioavailable Fe in human populations that consume these beans as a dietary staple. This justifies further work on the large-seeded Andean beans which are the staple of a large-region of Africa where iron-deficiency anemia is a primary cause of infant death and poor health status.

  19. 36 CFR 7.8 - Sequoia and Kings Canyon National Parks.

    Science.gov (United States)

    2010-07-01

    ... National Parks. 7.8 Section 7.8 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.8 Sequoia and Kings Canyon National Parks. (a) Dogs and cats. Dogs and cats are prohibited on any park land or trail except within one...

  20. Carbon and nutrient contents in soils from the Kings River Experimental Watersheds, Sierra Nevada Mountains, California

    Science.gov (United States)

    D.W. Johnson; C.T. Hunsaker; D.W. Glass; B.M. Rau; B.A. Roath

    2011-01-01

    Soil C and nutrient contents were estimated for eight watersheds in two sites (one high elevation, Bull, and one low elevation, Providence) in the Kings River Experimental Watersheds in the western Sierra Nevada Mountains of California. Eighty-seven quantitative pits were dug to measure soil bulk density and total rock content, while three replicate surface samples...

  1. The Crescent Bypass: A Riparian Restoration Project on the Kings River (Fresno County)

    Science.gov (United States)

    Jonathan A. Oldham; Bradley E. Valentine

    1989-01-01

    The Kings River Conservation District planted over 1200 plants of 19 riparian species in the first of two phases of a riparian revegetation project in the San Joaquin Valley. To date, tree survival rates vary from 17 to 96 percent among species, with an overall rate of 62 percent. Shrub survival averages 57 percent and ranges from 23 to 73 percent. Factors affecting...

  2. Metabolic response to lipid infusion in fasting winter-acclimatized king penguin chicks (Aptenodytes patagonicus).

    Science.gov (United States)

    Teulier, Loïc; Tornos, Jérémy; Rouanet, Jean-Louis; Rey, Benjamin; Roussel, Damien

    2013-05-01

    During the cold austral winter, king penguin chicks are infrequently fed by their parents and thus experience severe nutritional deprivation under harsh environmental conditions. These energetic constraints lead to a range of energy sparing mechanisms balanced by the maintenance of efficient thermogenic processes. The present work investigated whether the high thermogenic capacities exhibited by winter-acclimatized king penguin chicks could be related to an increase in lipid substrate supply and oxidation in skeletal muscle, the main site of thermogenesis in birds. To test this hypothesis, we examined i) the effect of an experimental rise in plasma triglyceride on the whole metabolic rate in winter-acclimatized (WA) and de-acclimatized king penguin chicks kept at thermoneutrality (TN), and ii) investigated the fuel preference of muscle mitochondria. In vivo, a perfusion of a lipid emulsion induced a small 10% increase of metabolic rate in WA chicks but not in TN group. In vitro, the oxidation rate of muscle mitochondria respiring on lipid-derived substrate was +40% higher in WA chicks than in TN, while no differences were found between groups when mitochondria oxidized carbohydrate-derived substrate or succinate. Despite an enhanced fuel selection towards lipid oxidation in skeletal muscle, a rise of circulating lipids per se was not sufficient to fully unravel the thermogenic capacity of winter-acclimatized king penguin chicks. Copyright © 2013 Elsevier Inc. All rights reserved.

  3. Two versions of solomon's prayer (1 kings 8 and 2 chronicles 6): a ...

    African Journals Online (AJOL)

    . We find this prayer in two different theological and literary traditions of the Bible: 1 Kings 8:22-53 and 2 Chronicles 6:12-42. In the light of these parallel versions one may pose the following questions: What are the similarities and differences ...

  4. "Free at Last": Kennedy, King, and the Meaning of Liberty in the Disability Rights Movement

    Science.gov (United States)

    Turnbull, H. Rutherford, III

    2012-01-01

    There is a direct link connecting President Kennedy and Martin Luther King, Jr., to the causes of liberty, consent, choice, the least restrictive environment, and genuine community presence for people with intellectual and related developmental disabilities. This article connects the meaning of liberty in those civil rights movements to the…

  5. Willingness to Communicate in English: A Case Study of EFL Students at King Khalid University

    Science.gov (United States)

    Mahdi, Dawood Ahmed

    2014-01-01

    The main purpose of learning a foreign language is to use it for meaningful and effective communication both inside and outside the classroom. This paper is devoted to identifying the main communication difficulties faced by EFL students at King Khalid University (KKU) and exploring the reasons that lie behind these difficulties. The paper…

  6. The work of nostalgia in Denis Hirson's I Remember King Kong (The ...

    African Journals Online (AJOL)

    This paper examines the work of nostalgia in Denis Hirson's I Remember King Kong (The Boxer), a poetic memoir of childhood that met with both critical acclaim and remarkable commercial success when it was published in South Africa in 2004. The book provides a telling case study of the multifaceted operation of ...

  7. King Cotton's Lasting Legacy of Poverty and Southern Region Contemporary Conditions

    Science.gov (United States)

    Guthrie, James W.; Peevely, Gary

    2010-01-01

    One hundred fifty years ago, cotton was considered as the king of all United States' agricultural exports. Cotton's dollar value far exceeded that of any other mid-19th-century United States trade item, much more than tobacco, fish, forest products, raw materials for manufacturing, or manufactured items. Indeed, in the mid-19th century, cotton was…

  8. Conservative nutrient use by big-leaf mahogany (Swietenia macrophylla King) planted under contrasting environmental conditions

    Science.gov (United States)

    E. Medina; E. Cuevas; A.E. Lugo; E. Terezo; J. Jimenez-Osornio; P.A. Macario-Mendoza; P. Montanez

    2014-01-01

    We analyzed the nutritional composition and isotope ratios (C and N) of big-leaf mahogany (Swietenia macrophylla King) leaves in plantations established on contrasting soils and climates in Central America (State of Quintana Roo, Yucatan, Mexico) and South America (State of Para, Brazil). The objective was to determine the adaptability of this species to large...

  9. Martin Luther King, Jr.: A Lesson with Interdisciplinary Connections for Middle-Level Music Students.

    Science.gov (United States)

    Early, Mary Frances; Terry, Cynthia

    This lesson begins with a very brief biography of Martin Luther King, Jr. The lesson identifies its educational objectives; addresses National Standards for Music Education; lists materials needed; details six step-by-step classroom procedures for lesson implementation; and provides curriculum connections for language arts, visual art, physical…

  10. "I Have a Dream, Too!": The American Dream in Coretta Scott King Award-Winning Books

    Science.gov (United States)

    Parsons, Linda T.; Castleman, Michele

    2011-01-01

    The Coretta Scott King (CSK) Award, instituted in 1969 and recognized as an official award by the American Library Association (ALA) in 1982, is conferred annually to an African American author and an illustrator for their outstanding contributions to literature about the Black experience for children and young adults. A partial impetus for the…

  11. Matthew's Messianic Shepherd-king: In search of “the lost sheep of ...

    African Journals Online (AJOL)

    p1243322

    23-9:1 in Matthew 4:15-16. The investigation considers both Matthew's text- .... support a concrete eschatological expectation of national-political restoration for all Israel under one Davidic King. With the contextual parameters in place to guide ...

  12. 78 FR 38313 - Kings River Conservation District; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2013-06-26

    ... Conservation District; Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments and Motions To Intervene On June 3, 2013, the Kings River Conservation District filed an application, pursuant... strongly encourages electronic filing, documents may also be paper-filed. To paper-file, mail an original...

  13. Portraits of the Postmodern Person in "Taxi Driver,""Raging Bull," and "The King of Comedy."

    Science.gov (United States)

    Mortimer, Barbara

    1997-01-01

    Argues that a postmodern theory of identity (i.e., the subject as coherent, integrated, discoverable self is a fiction of modernity) links Martin Scorsese's major films. Examines "Taxi Driver,""Raging Bull," and "King of Comedy." Concludes that these films articulate a major cultural shift and chronicle a…

  14. Examples of Mechanism Design : From King Solomon to eBay

    NARCIS (Netherlands)

    De Weerdt, M.M.

    2007-01-01

    The judgment of king Solomon is an early example of mechanism design. Mechanism design attempts to achieve desired outcomes in situations with self-interested players by setting the rules of the game in a specific way. We will see that the game Solomon proposed would not have worked if the women

  15. Africa in the imaginary: the geographical explorations of the king Juba II of Mauretania

    Directory of Open Access Journals (Sweden)

    Enrique GOZALBES CRAVIOTO

    2012-03-01

    Full Text Available In the present study we analyzed the different texts of the Latin encyclopaedist Plinio, specially the texts that refer to the geographical explorations of the king Juba II of Mauretania. These explorations developed from two directions, the Atlantic Africa and the mountain chain of the Atlas. Juba II contemplated both cases from the own image inherited from the African continent.

  16. 76 FR 23335 - Wilderness Stewardship Plan/Environmental Impact Statement, Sequoia and Kings Canyon National...

    Science.gov (United States)

    2011-04-26

    .../WSP when it is released, or just wish to receive a notice that the document is available for review on... available at any time. While you can ask us in your comment to withhold your personal identifying... Intent to Prepare Environmental Impact Statement for Wilderness Stewardship Plan, Sequoia and Kings...

  17. Pengolahan Biji Mahoni (Swietenia Macrophylla King) Sebagai Bahan Baku Alternatif Biodiesel

    OpenAIRE

    Damayanti, Astrilia; Bariroh, Siti

    2012-01-01

    Peningkatan kebutuhan minyak bumi yang terus menerus akan mengakibatkan kelangkaan bahan bakar minyak. Sumber energi alternatif yang ramah lingkungan, salah satunya adalah biodiesel. Bahan baku potensial untuk memproduksi biodiesel yang tidak bersaing dengan bahan baku pangan contohnya adalah biji mahoni (swietenia macrophylla king). Tahapan yang diperlukan dalam percobaan biodiesel adalah proses pengambilan minyak biji mahoni dengan proses penyangraian, degumming, dan proses transesterifikas...

  18. The King and Prisoner Puzzle: A Way of Introducing the Components of Logical Structures

    Science.gov (United States)

    Roh, Kyeong Hah; Lee, Yong Hah; Tanner, Austin

    2016-01-01

    The purpose of this paper is to provide issues related to student understanding of logical components that arise when solving word problems. We designed a logic problem called the King and Prisoner Puzzle--a linguistically simple, yet logically challenging problem. In this paper, we describe various student solutions to the puzzle and discuss the…

  19. Errors Analysis of Solving Linear Inequalities among the Preparatory Year Students at King Saud University

    Science.gov (United States)

    El-khateeb, Mahmoud M. A.

    2016-01-01

    The purpose of this study aims to investigate the errors classes occurred by the Preparatory year students at King Saud University, through analysis student responses to the items of the study test, and to identify the varieties of the common errors and ratios of common errors that occurred in solving inequalities. In the collection of the data,…

  20. Multiple Intelligences Patterns of Students at King Saud University and Its Relationship with Mathematics' Achievement

    Science.gov (United States)

    Kandeel, Refat A. A.

    2016-01-01

    The purpose of this study was to determine the multiple intelligences patterns of students at King Saud University and its relationship with academic achievement for the courses of Mathematics. The study sample consisted of 917 students were selected a stratified random manner, the descriptive analysis method and Pearson correlation were used, the…

  1. AFSC/RACE/SAP/Long: Effects of ocean acidification on blue king crab

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This is data from a laboratory experiment in which blue king crab juveniles were held at three different pHs (ambient, pH 7.8, and pH 7.5) for a year. Growth,...

  2. ‘The Cognate Verbs sym and swm in the Books of Kings: Similarities and Differences’

    NARCIS (Netherlands)

    Dyk, J.W.; Heal, K.; Salveson, A.

    2013-01-01

    In a joint effort of the Peshitta Institute Leiden and the Werkgroep Informatica of the Vrije Universiteit Amsterdam an electronic database of Syriac texts is being developed. Percy van Keulen and I have been assigned the Books of Kings, which we have analyzed from morpheme level up through

  3. Siim Nestor soovitab : Goldie. Kevin Saunderson. Nicole Willis. King Britt / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2005-01-01

    Popmuusikaüritustest: briti muusik Goldie esineb jungle-muusikaga Tallinnas 21. apr. klubis Privé, DJ Kevin Saunderson 22. apr. klubis Privé, laulja Nicole Willis 27. apr. BonBon Jazz Lounge'il klubis BonBon, Philadelphia muusik King Britt ja Eesti ansambel Broken Time Orchestra esitlevad oma heliplaate

  4. Wole Soyinka's A Play of Giants and King Baabu : The crises ...

    African Journals Online (AJOL)

    This paper, using Soyinka's A Play of Giants and King Baabu, re-examines the centrality of ideology to texts of social engagement in the postcolonial space. Within the context of the humanistic values that the playwright esteems, this essay scrutinizes the social conditions in the plays and the dramatist's “vision.

  5. Critical Discourse Analysis of Martin Luther King's Speech in Socio-Political Perspective

    Science.gov (United States)

    Sipra, Muhammad Aslam; Rashid, Athar

    2013-01-01

    The article presents the Critical Discourse Analysis (CDA) of the first part of King Martin Luther's speech "When I Have a Dream" in socio-political context. The study investigates how it lies on the basis of application of Fairclough version of CDA in the first part of the text. Moreover, it explicates the terms like social, cultural…

  6. 3 CFR 8340 - Proclamation 8340 of January 15, 2009. Martin Luther King, Jr., Federal Holiday, 2009

    Science.gov (United States)

    2010-01-01

    ... recognize one of history’s most consequential advocates for equality and civil rights, and we celebrate his... government but a gift from the Author of Life. Dr. King trusted in these beliefs articulated in our founding... ideals of America and protecting every person’s God-given rights. The historic election of Barack Obama...

  7. Whose drag is it anyway? Drag kings and monarchy in the UK.

    Science.gov (United States)

    Willox, Annabelle

    2002-01-01

    This chapter will show that the term "drag" in drag queen has a different meaning, history and value to the term "drag" in drag king. By exposing this basic, yet fundamental, difference this paper will expose the problems inherent in the assumption of parity between the two forms of drag. An exposition of how camp has been used to comprehend and theorise drag queens will facilitating an understanding of the parasitic interrelationship between camp and drag queen performances, while a critique of "Towards a Butch-Femme Aesthetic," by Sue Ellen Case, will point out the problematic assumptions made about camp when attributed to a cultural location different to the drag queen. By interrogating the historical, cultural and theoretical similarities and differences between drag kings, butches, drag queens and femmes this paper will expose the flawed assumption that camp can be attributed to all of the above without proviso, and hence expose why drag has a fundamentally different contextual meaning for kings and queens. This chapter will conclude by examining the work of both Judith Halberstam and Biddy Martin and the practical examples of drag king and queen performances provided at the UK drag contest held at The Fridge in Brixton, London on 23 June 1999.

  8. Women king makers: the case of Zulu princess Mkabayi Kajama (c ...

    African Journals Online (AJOL)

    Zulu culture is fraught with a plethora of women, the most important of whom were princess Mkabayi kaJama; queen Nandi, the mother of Emperor Shaka and also queen Monase who contributed in shaping the Zulu monarchy to what it became in the late 18th and early 19th centuries and making kings behind the scenes.

  9. Has the Dream Been Fulfilled? Dr. Martin Luther King, Jr. & President Barack Hussein Obama

    Science.gov (United States)

    Robinson, Nichelle Boyd; Moore, Virginia J.; Williams-Black, Thea H.

    2015-01-01

    Equality for all was the dream of Dr. Martin Luther King, Jr. and he knowingly laid the foundation for and inspired the first African-American President of the United States of America, Barack Hussein Obama, who also had the dream of "Change" for America. These men exhibited how working together can make dreams become reality. For the…

  10. RISK MANAGEMENT DISCLOSURE PRACTICESIN ACCORDANCEWITH KING II AND III: THE CASE OF SELECTED JSE LISTEDCOMPANIES

    Directory of Open Access Journals (Sweden)

    Heleen Janse van Vuuren

    2016-07-01

    Full Text Available The ongoing collapse of large international companies could have been partiallyprevented if good corporate governance principles and,more specifically,effectiverisk management practices had been implemented and adhered to.Research reveals that the majority offinancial institutions in Europe do notmanage risk effectively and the global financial crisis proved that excessive risk-taking can result in corporate failure. Similar trends are prevalent in South Africa.The aim of this research was to investigate the compliance of Johannesburg StockExchange (JSE listed companies with recommended risk management practicesand disclosure requirements after the introduction of King II and III. To achievethis the annual reports ofselectedJSElisted companies were evaluated toestablish the quality of their reporting on risk management practices asrecommended in King II andIII. The results of the study indicated that theminority of the companies investigated, fully complied with all the recommendedrequirements. This study contributed to literature by showing that althoughdisclosure on risk management practicesimproved significantly since King IIbecame operational in 2002, companies still did not adhere to all the requirementsas stipulated even after King III became effectivein 2010. The finding, therefore,supports the notion that full compliance is an evolutionary process, rather than arevolutionary process and will therefore only be achieved over time.

  11. Aspects of the biology of three benthic-feeding teleosts from King's ...

    African Journals Online (AJOL)

    Department of Zoology, University of Port Elizabeth, Port Elizabeth. The lengths, abundance pattems and feeding habits of three species of benthic·feeding teleosts, Lithognathus mormyrus,. Lithognathus lithognathus and Umbrina capensis from King's. Beach, Algoa Bay are presented. Multiple regression analysis was.

  12. The Analysis of Demagogic Discourse: Huey Long's "Every Man a King" Address.

    Science.gov (United States)

    Gaske, Paul C.

    The characteristics of demagogic discourse and a methodology appropriate for its analysis can be illustrated by examining Huey Long's "Every Man a King" radio address on February 20, 1934. The demagogue is similar to the revered public figure in that both are mass leaders, charismatic, and heroic. But the demagogue elicits powerful…

  13. Volume reduction of the jugular foramina in Cavalier King Charles Spaniels with syringomyelia

    Directory of Open Access Journals (Sweden)

    Schmidt Martin

    2012-09-01

    Full Text Available Abstract Background Understanding the pathogenesis of the chiari-like malformation in the Cavalier King Charles Spaniel (CKCS is incomplete, and current hypotheses do not fully explain the development of syringomyelia (SM in the spinal cords of affected dogs. This study investigates an unconventional pathogenetic theory for the development of cerebrospinal fluid (CSF pressure waves in the subarachnoid space in CKCS with SM, by analogy with human diseases. In children with achondroplasia the shortening of the skull base can lead to a narrowing of the jugular foramina (JF between the cranial base synchondroses. This in turn has been reported to cause a congestion of the major venous outflow tracts of the skull and consequently to an increase in the intracranial pressure (ICP. Amongst brachycephalic dog breeds the CKCS has been identified as having an extremely short and wide braincase. A stenosis of the JF and a consequential vascular compromise in this opening could contribute to venous hypertension, raising ICP and causing CSF jets in the spinal subarachnoid space of the CKCS. In this study, JF volumes in CKCSs with and without SM were compared to assess a possible role of this pathologic mechanism in the development of SM in this breed. Results Computed tomography (CT scans of 40 CKCSs > 4 years of age were used to create three-dimensional (3D models of the skull and the JF. Weight matched groups (7–10 kg of 20 CKCSs with SM and 20 CKCSs without SM were compared. CKCSs without SM presented significantly larger JF -volumes (median left JF: 0.0633 cm3; median right JF: 0.0703 cm3; p 3; median right JF: 0.0434 cm3; p Conclusion A stenosis of the JF and consecutive venous congestion may explain the aetiology of CSF pressure waves in the subarachnoid space, independent of cerebellar herniation, as an additional pathogenetic factor for the development of SM in this breed.

  14. Increased patient delays in care after the closure of Martin Luther King Hospital: implications for monitoring health system changes.

    Science.gov (United States)

    Walker, Kara Odom; Leng, Mei; Liang, Li-Jung; Forge, Nell; Morales, Leo; Jones, Loretta; Brown, Arleen

    2011-01-01

    The safety net system remains an important part of the health care system for uninsured and minority populations, however, the closure of safety net hospitals changes the availability of care. Using community-based participatory research methods, we explored the impact of hospital closure among late middle aged and elderly racial/ethnic minorities in South Los Angeles. Telephone survey of participants in both 2008, after hospital closure, and 2003, before hospital closure, who self-identified as African American or Latino, were over the age of 50 and lived in zip codes of South Los Angeles. We developed multiple logistic regression models on imputed data sets weighted for non-response and adjusted for self-reported measures of demographic and clinical characteristics to examine the odds of reporting delays in care. After adjusting for covariates known to influence access to care and distributed differently in the two survey samples, we found significantly greater delays in care. Following the closure of the Martin Luther King, Jr. safety net hospital, the adjusted odds ratios were 1.70 (95% CI 1.01, 2.87) for delays in care, 1.88 (95% Cl 1.06, 3.13) for problems receiving needed medical care, and 2.62 (95% CI 1.46, 4.67) for seeing a specialist. Our survey of older minority adults in South Los Angeles found increased delays in access to care for needed medical services after the closure of Martin Luther King, Jr. Hospital. As health care reform unfolds, monitoring for changes in access to care that may result from new policies will be important to address future disparities, particularly for vulnerable populations.

  15. Kinship--king's social harmonisation project. Pilot phase of a social network for use in higher education (HE).

    Science.gov (United States)

    John, B A

    2013-05-08

    Students entering Higher Education are increasingly information and communications technology literate. Many students (graduates and undergraduates) arrive as "digital residents", who are adept with social media and technologically fluent. The informal use of social media for learning is becoming increasingly evident, along with the potentially detrimental effects of a poor digital profile on employment prospects. This paper describes the creation of Kinship (King's Social Harmonisation Project), a university hosted, members only social network, which is currently being piloted in the Medical School at King's College London. Along with a number of other teaching and learning resources, it is intended to use Kinship to establish an informal code of conduct by modelling and moderating appropriate professional online behaviour. Kinship was developed using an open source Elgg platform, thanks to funding of £20,000 from the College Teaching Fund under the mentorship of Brighton University (1). This educational research project, led by Medicine, was proposed to select, customise and evaluate a social networking platform in order to provide functionality that would enhance new and existing e-learning resources, support group interaction, participation and sharing and meet the diverse needs of three academic schools: Medicine, the Dental Institute and two separate Departments, the Modern Languages Centre and the Department of English from Arts & Humanities, as a pilot for wider College deployment. Student involvement is central to the project, from conducting the evaluation to moulding and customising the functionality and look of Kinship, in order to ensure that the site is authentic and evolves in response to their wishes and requirements. Formal evaluation of Kinship commences summer 2012.

  16. Modeling Heterogeneous Fishing Fleet in an Ecosystem Based Management Context

    DEFF Research Database (Denmark)

    Hutniczak, Barbara

    perturbations in the fragile Arctic ecosystems are likely to have outsized impacts both ecologically and economically. This work discusses the optimal management of international invasive species threats in order to minimize overall damages and costs. The related cases of the purposeful introduction of the red...... king crab (RKC) and the accidental introduction of the snow crab in the Barents Sea, and the red king crab’s recent identification in Icelandic waters, are used to develop the discussion of the tradeoffs, local, regional and international governance opportunities and failures, and intervention...

  17. Hydrochemical assessment of freshening saline groundwater using multiple end-members mixing modeling: A study of Red River delta aquifer, Vietnam

    Science.gov (United States)

    Kim, Ji-Hyun; Kim, Kyoung-Ho; Thao, Nguyen Thi; Batsaikhan, Bayartungalag; Yun, Seong-Taek

    2017-06-01

    In this study, we evaluated the water quality status (especially, salinity problems) and hydrogeochemical processes of an alluvial aquifer in a floodplain of the Red River delta, Vietnam, based on the hydrochemical and isotopic data of groundwater samples (n = 23) from the Kien Xuong district of the Thai Binh province. Following the historical inundation by paleo-seawater during coastal progradation, the aquifer has been undergone progressive freshening and land reclamation to enable settlements and farming. The hydrochemical data of water samples showed a broad hydrochemical change, from Na-Cl through Na-HCO3 to Ca-HCO3 types, suggesting that groundwater was overall evolved through the freshening process accompanying cation exchange. The principal component analysis (PCA) of the hydrochemical data indicates the occurrence of three major hydrogeochemical processes occurring in an aquifer, namely: 1) progressive freshening of remaining paleo-seawater, 2) water-rock interaction (i.e., dissolution of silicates), and 3) redox process including sulfate reduction, as indicated by heavy sulfur and oxygen isotope compositions of sulfate. To quantitatively assess the hydrogeochemical processes, the end-member mixing analysis (EMMA) and the forward mixing modeling using PHREEQC code were conducted. The EMMA results show that the hydrochemical model with the two-dimensional mixing space composed of PC 1 and PC 2 best explains the mixing in the study area; therefore, we consider that the groundwater chemistry mainly evolved by mixing among three end-members (i.e., paleo-seawater, infiltrating rain, and the K-rich groundwater). The distinct depletion of sulfate in groundwater, likely due to bacterial sulfate reduction, can also be explained by EMMA. The evaluation of mass balances using geochemical modeling supports the explanation that the freshening process accompanying direct cation exchange occurs through mixing among three end-members involving the K-rich groundwater. This

  18. Interactions between surface waters in King George Island, Antarctica - a stable isotope perspective

    Science.gov (United States)

    Perşoiu, Aurel; Bădăluşă, Carmen

    2017-04-01

    In this paper we present a first study of the isotopic composition of surface waters in the southern peninsulas (Barton, Fildes, Weaver and Potter) of King George Island, Antarctica. We have collected > 200 samples of snow and snowmelt, water (lake, river and spring), ice (glacier ice and permafrost) from the four peninsulas in February 2016 and analyzed them for their oxygen and hydrogen stable isotopic composition. Samples from lake water (50+) indicate a clear west-east depletion trend, suggesting a rain-out process as air masses are moving westward (and are progressively depleted in heavy isotopes) from their origin in the Drake Passage. In both Fildes and Barton Peninsulas, permafrost samples have the heaviest isotopic composition, most probably due to preferential incorporation of heavy isotopes in the ice during freezing (and no fractionation during melting). As permafrost melts, the resulting water mixes with isotopically lighter infiltrated snowmelt, and thus the groundwater has a lower isotopic composition. Further, lake and river (the later fed by lakes) water has the lightest isotopic composition, being derived mostly from the melting of light snow and glacier ice. It seems feasible to separate isotopically water in lakes/rivers (largely fed by melting multi-year glaciers and snow) and water from melting of snow/ground ice This preliminary study suggests that it is possible to separate various water sources in the southern peninsulas of King George Island, and this separation could be used to study permafrost degradation, as well as feeding and migration patterns in the bird fauna, with implications for protection purposes. Acknowledgments. The National Institute of Research and Development for Biological Sciences (Bucharest, Romania) and the Korean polar institute financially supported fieldwork in King George Island. We thank the personal at King Sejong (South Korea), Belingshaussen (Russia) and Carlini (Argentina) stations in King George Island for

  19. FERMENTATION QUALITY OF KING GRASS SILAGE TREATED WITH LIQUID OR DRIED INOCULANT OF LACTIC ACID BACTERIA

    Directory of Open Access Journals (Sweden)

    B. Santoso

    2016-03-01

    Full Text Available The aim of this study was to evaluate the nutritive value and fermentation characteristic of king grass silage treated with addition of liquid or dried lactic acid bacteria (LAB inoculant. Experiment was arranged to a completely randomized design with four treatments and three replications. Four treatments as follows (A king grass without LAB inoculant as the control; (B king grass + 30 ml of liquid of epiphytic LAB inoculant/kg of fresh forage; (C king grass + 30 g of freeze-dried powder of LAB inoculant/kg of fresh forage; (D king grass + 30 g of centrifuged powder of LAB inoculant/kg of fresh forage. The liquid LAB inoculant was sprayed on the top of grass and then mannualy mixed by hand. The intial LAB concentration in all inoculants were 1.0 × 106 cfu/g. About 500 g of silage materials were ensiled into plastic silos and stored at room temperatures (approximately 28oC for 30 days. Results showed that pH value, concentrations of lactic acid, N-amonia (NH3-N, butyric acid and total volatile fatty acids (VFA as well as Fleigh Point were affected by treatment of LAB inoculant. Silage treated with liquid or dried of LAB inoculant had lower (P<0.01 pH value compared to the control silage. Concentrations of NH3-N and butyric acid significantly decreased (P<0.01 in silage treated with LAB inoculants. Silage treated with centrifuged powder of LAB inoculant had the highest (P<0.05 Fleigh Point than other silage. In vitro neutral detergent fiber (NDF digestibility was significantly higher (P<0.05 in silage treated with LAB inoculant compared to the control silage.

  20. Complementing data-driven and physically-based approaches for predictive morphologic modeling: Results and implication from the Red River Basin, Vietnam

    Science.gov (United States)

    Schmitt, R. J.; Bernardi, D.; Bizzi, S.; Castelletti, A.; Soncini-Sessa, R.

    2013-12-01

    During the last 30 years, the delta of the Red River (Song Hong) in northern Vietnam experienced grave morphologic degradation processes which severely impact economic activities and endanger region-wide livelihoods. Rapidly progressing river bed incision, for example, threatens the irrigation of the delta's paddy rice crops which constitute 20% of Vietnam's annual rice production. Morphologic alteration is related to a drastically changed sediment balance due to major upstream impoundments, sediment mining and land use changes, further aggravated by changing hydro-meteorological conditions. Despite the severe impacts, river morphology was so far not included into the current efforts to optimize basin wide water resource planning for a lack of suitable, not overly resource demanding modeling strategies. This paper assesses the suitability of data-driven models to provide insights into complex hydromorphologic processes and to complement and enrich physically-based modeling strategies. Hence, to identify key drivers of morphological change while evaluating impacts of future socio-economic, management and climate scenarios on river morphology and the resulting effects on key social needs (e.g. water supply, energy production and flood mitigation). Most relevant drivers and time-scales for the considered processes (e.g. incision) - from days to decades - were identified from hydrologic and sedimentologic time-series using a feature ranking algorithm based on random trees. The feature ranking pointed out bimodal response characteristics, with important contributions of long-to-medium (5 - 15 yrs.) and rather short (10d - 6 months) timescales. An artificial neural network (ANN), built from identified variables, subsequently quantified in detail how these temporal components control long term trends, inter-seasonal fluctuations and day to day variations in morphologic processes. Whereas the general trajectory of incision relates, for example, to the overall regional