WorldWideScience

Sample records for model study design

  1. Study design in causal models

    OpenAIRE

    2012-01-01

    The causal assumptions, the study design and the data are the elements required for scientific inference in empirical research. The research is adequately communicated only if all of these elements and their relations are described precisely. Causal models with design describe the study design and the missing data mechanism together with the causal structure and allow the direct application of causal calculus in the estimation of the causal effects. The flow of the study is visualized by orde...

  2. Study of the ship design process model for collaborative design

    Science.gov (United States)

    He, Ze; Qiu, Chang-Hua; Wang, Neng-Jian

    2005-09-01

    The ship design process model is the basis for developing the ship collaborative design system under network environment. According to the characteristics of the ship design, a method for dividing the ship design process into, three layers is pat forward, that is project layer, design task layer and design activity layer, then the formalized definitions of the ship design process model, the decomposing principles of the ship design process and the architecture of the ship collaborative design (SDPM) system are presented. This method simplifies the activity network makes the optimization and adjustment of the design plan convenient and also makes the design process easier to control and change, at last the architecture of the ship collaborative design system is discussed.

  3. Study of the ship design process model for collaborative design

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The ship design process model is the basis for developing the ship collaborative design system under network environment.According to the characteristics of the ship design, a method for dividing the ship design process into three layers is pat forward, that is project layer, design task layer and design activity layer, then the formalized definitions of the ship design process model, the decomposing principles of the ship design process and the architecture of the ship collaborative design (SDPM) system are presented. This method simplifies the activity network, makes the optimization and adjustment of the design plan convenient and also makes the design process easier to control and change, at last the architecture of the ship collaborative design system is discussed.

  4. A warehouse design decision model: case study

    OpenAIRE

    Geraldes, Carla A. S. (Ed.); Carvalho, Maria do Sameiro; Pereira, Guilherme

    2008-01-01

    Today’s competitive and volatile market requires flexibility, quality and efficiency from the logistics operations. In this context, warehouses are an important link of the logistic chain and warehouse management plays an important role over customer's service. Throughout this work we analyze a mathematical model aiming to support warehouse management decisions. A case study is used for that purpose and the model jointly identifies product allocation to the functional areas in the warehouse, ...

  5. Modelling a case study in Astronomy with IMS Learning Design

    NARCIS (Netherlands)

    Burgos, Daniel; Tattersall, Colin

    2009-01-01

    Burgos, D., & Tattersall, C. (2008). Modelling a case study in Astronomy with IMS Learning Design [Electronic Version]. Journal of Interactive Media in Education, 2008 from http://jime.open.ac.uk/2008/19/.

  6. Conflicts Management Model in School: A Mixed Design Study

    Science.gov (United States)

    Dogan, Soner

    2016-01-01

    The object of this study is to evaluate the reasons for conflicts occurring in school according to perceptions and views of teachers and resolution strategies used for conflicts and to build a model based on the results obtained. In the research, explanatory design including quantitative and qualitative methods has been used. The quantitative part…

  7. Improving the analysis of designed studies by combining statistical modelling with study design information

    NARCIS (Netherlands)

    Thissen, U.; Wopereis, S.; van Berg, S.A.A.; Bobeldijk, I.; Kleemann, R.; Kooistra, T.; van Dijk, K.W.; van Ommen, B.; Smilde, A.K.

    2009-01-01

    Background: In the fields of life sciences, so-called designed studies are used for studying complex biological systems. The data derived from these studies comply with a study design aimed at generating relevant information while diminishing unwanted variation (noise). Knowledge about the study

  8. FEM numerical model study of electrosurgical dispersive electrode design parameters.

    Science.gov (United States)

    Pearce, John A

    2015-01-01

    Electrosurgical dispersive electrodes must safely carry the surgical current in monopolar procedures, such as those used in cutting, coagulation and radio frequency ablation (RFA). Of these, RFA represents the most stringent design constraint since ablation currents are often more than 1 to 2 Arms (continuous) for several minutes depending on the size of the lesion desired and local heat transfer conditions at the applicator electrode. This stands in contrast to standard surgical activations, which are intermittent, and usually less than 1 Arms, but for several seconds at a time. Dispersive electrode temperature rise is also critically determined by the sub-surface skin anatomy, thicknesses of the subcutaneous and supra-muscular fat, etc. Currently, we lack fundamental engineering design criteria that provide an estimating framework for preliminary designs of these electrodes. The lack of a fundamental design framework means that a large number of experiments must be conducted in order to establish a reasonable design. Previously, an attempt to correlate maximum temperatures in experimental work with the average current density-time product failed to yield a good match. This paper develops and applies a new measure of an electrode stress parameter that correlates well with both the previous experimental data and with numerical models of other electrode shapes. The finite element method (FEM) model work was calibrated against experimental RF lesions in porcine skin to establish the fundamental principle underlying dispersive electrode performance. The results can be used in preliminary electrode design calculations, experiment series design and performance evaluation.

  9. Design models as emergent features: An empirical study in communication and shared mental models in instructional

    Directory of Open Access Journals (Sweden)

    Lucca Botturi

    2006-06-01

    Full Text Available This paper reports the results of an empirical study that investigated the instructional design process of three teams involved in the development of an e-learning unit. The teams declared they were using the same fast-prototyping design and development model, and were composed of the same roles (although with a different number of SMEs. Results indicate that the design and development model actually informs the activities of the group, but that it is interpreted and adapted by the team for the specific project. Thus, the actual practice model of each team can be regarded as an emergent feature. This analysis delivers insights concerning issues about team communication, shared understanding, individual perspectives and the implementation of prescriptive instructional design models.

  10. The Learner-Centered Instructional Design Model: A Modified Delphi Study

    Science.gov (United States)

    Melsom, Duane Allan

    2010-01-01

    The learner-centered instructional design model redefines the standard linear instructional design model to form a circular model where the learner's needs are the first item considered in the development of instruction. The purpose of this modified Delphi study was to have a panel of experts in the instructional design field review the…

  11. Interpretive and Critical Phenomenological Crime Studies: A Model Design

    Science.gov (United States)

    Miner-Romanoff, Karen

    2012-01-01

    The critical and interpretive phenomenological approach is underutilized in the study of crime. This commentary describes this approach, guided by the question, "Why are interpretive phenomenological methods appropriate for qualitative research in criminology?" Therefore, the purpose of this paper is to describe a model of the interpretive…

  12. Basic model study on efficiency evaluation in collaborative design work process

    Institute of Scientific and Technical Information of China (English)

    XIE Qiu; YANG Yu; LI Xiaoli; ZHAO Ningyu

    2007-01-01

    During the efficiency evaluation process of collaborative design work,because of the lack of efficiency evaluation models,a basic analytical model for collaborative design work efficiency evaluation is proposed in this paper.First,the characteristics of the networked collaborative design system work process were studied; then,in accordance with those characteristics,a basic analytical model is created.This model,which is built for centralized collaborative design work,includes an analytical frame,a process view model,a function view model and an information view model.Finally,the application process and steps of this basic analytical model are elaborated when used for efficiency evaluation through an experiment.

  13. Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models

    OpenAIRE

    Nguyen, Thu Thuy; Bazzoli, Caroline; Mentré, France

    2012-01-01

    International audience; Bioequivalence or interaction trials are commonly studied in crossover design and can be analysed by nonlinear mixed effects models as an alternative to noncompartmental approach. We propose an extension of the population Fisher information matrix in nonlinear mixed effects models to design crossover pharmacokinetic trials, using a linearisation of the model around the random effect expectation, including within-subject variability and discrete covariates fixed or chan...

  14. Optimal designs for discriminating between dose-response models in toxicology studies

    CERN Document Server

    Dette, Holger; Shpilev, Piter; Wong, Weng Kee; 10.3150/10-BEJ257

    2010-01-01

    We consider design issues for toxicology studies when we have a continuous response and the true mean response is only known to be a member of a class of nested models. This class of non-linear models was proposed by toxicologists who were concerned only with estimation problems. We develop robust and efficient designs for model discrimination and for estimating parameters in the selected model at the same time. In particular, we propose designs that maximize the minimum of $D$- or $D_1$-efficiencies over all models in the given class. We show that our optimal designs are efficient for determining an appropriate model from the postulated class, quite efficient for estimating model parameters in the identified model and also robust with respect to model misspecification. To facilitate the use of optimal design ideas in practice, we have also constructed a website that freely enables practitioners to generate a variety of optimal designs for a range of models and also enables them to evaluate the efficiency of ...

  15. Modelling in Business Model design

    NARCIS (Netherlands)

    Simonse, W.L.

    2013-01-01

    It appears that business model design might not always produce a design or model as the expected result. However when designers are involved, a visual model or artefact is produced. To assist strategic managers in thinking about how they can act, the designers challenge is to combine strategy and

  16. Designing Business Model Change

    DEFF Research Database (Denmark)

    Cavalcante, Sergio Andre

    2014-01-01

    The aim of this paper is to base organisational change on the firm's business model, an approach that research has only recently start to address. This study adopts a process-based perspective on business models and insights from a variety of theories as the basis for the development of ideas...... on the design of business model change. This paper offers a new, process-based strategic analytical artefact for the design of business model change, consisting of three main phases. Designing business model change as suggested in this paper allows ex ante analysis of alternative scenarios of change...... in a structured and comprehensive way. Such a tool is useful for obtaining an overall view of the working logic of the firm and to facilitate innovation through change. The main contribution of this paper is to transform management theories into an instrument that can be helpful for companies to develop...

  17. Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models.

    Science.gov (United States)

    Nguyen, Thu Thuy; Bazzoli, Caroline; Mentré, France

    2012-05-20

    Bioequivalence or interaction trials are commonly studied in crossover design and can be analysed by nonlinear mixed effects models as an alternative to noncompartmental approach. We propose an extension of the population Fisher information matrix in nonlinear mixed effects models to design crossover pharmacokinetic trials, using a linearisation of the model around the random effect expectation, including within-subject variability and discrete covariates fixed or changing between periods. We use the expected standard errors of treatment effect to compute the power for the Wald test of comparison or equivalence and the number of subjects needed for a given power. We perform various simulations mimicking crossover two-period trials to show the relevance of these developments. We then apply these developments to design a crossover pharmacokinetic study of amoxicillin in piglets and implement them in the new version 3.2 of the r function PFIM.

  18. How does spatial study design influence density estimates from spatial capture-recapture models?

    Directory of Open Access Journals (Sweden)

    Rahel Sollmann

    Full Text Available When estimating population density from data collected on non-invasive detector arrays, recently developed spatial capture-recapture (SCR models present an advance over non-spatial models by accounting for individual movement. While these models should be more robust to changes in trapping designs, they have not been well tested. Here we investigate how the spatial arrangement and size of the trapping array influence parameter estimates for SCR models. We analysed black bear data collected with 123 hair snares with an SCR model accounting for differences in detection and movement between sexes and across the trapping occasions. To see how the size of the trap array and trap dispersion influence parameter estimates, we repeated analysis for data from subsets of traps: 50% chosen at random, 50% in the centre of the array and 20% in the South of the array. Additionally, we simulated and analysed data under a suite of trap designs and home range sizes. In the black bear study, we found that results were similar across trap arrays, except when only 20% of the array was used. Black bear density was approximately 10 individuals per 100 km(2. Our simulation study showed that SCR models performed well as long as the extent of the trap array was similar to or larger than the extent of individual movement during the study period, and movement was at least half the distance between traps. SCR models performed well across a range of spatial trap setups and animal movements. Contrary to non-spatial capture-recapture models, they do not require the trapping grid to cover an area several times the average home range of the studied species. This renders SCR models more appropriate for the study of wide-ranging mammals and more flexible to design studies targeting multiple species.

  19. Model of Values-Based Management Process in Schools: A Mixed Design Study

    Science.gov (United States)

    Dogan, Soner

    2016-01-01

    The aim of this paper is to evaluate the school administrators' values-based management behaviours according to the teachers' perceptions and opinions and, accordingly, to build a model of values-based management process in schools. The study was conducted using explanatory design which is inclusive of both quantitative and qualitative methods.…

  20. Designing Excellence and Quality Model for Training Centers of Primary Health Care: A Delphi Method Study

    Directory of Open Access Journals (Sweden)

    Jafar-Sadegh TABRIZI

    2015-10-01

    Full Text Available Background: Excellence and quality models are comprehensive methods for improving the quality of healthcare. The aim of this study was to design excellence and quality model for training centers of primary health care using Delphi method. Methods: In this study, Delphi method was used. First, comprehensive information were collected using literature review. In extracted references, 39 models were identified from 34 countries and related sub-criteria and standards were extracted from 34 models (from primary 39 models. Then primary pattern including 8 criteria, 55 sub-criteria, and 236 standards was developed as a Delphi questionnaire and evaluated in four stages by 9 specialists of health care system in Tabriz and 50 specialists from all around the country.Results: Designed primary model (8 criteria, 55 sub-criteria, and 236 standards were concluded with 8 criteria, 45 sub-criteria, and 192 standards after 4 stages of evaluations by specialists. Major criteria of the model are leadership, strategic and operational planning, resource management, information analysis, human resources management, process management, costumer results, and functional results, where the top score was assigned as 1000 by specialists. Functional results had the maximum score of 195 whereas planning had the minimum score of 60. Furthermore the most and the least sub-criteria was for leadership with 10 sub-criteria and strategic planning with 3 sub-criteria, respectively. Conclusion: The model that introduced in this research has been designed following 34 reference models of the world. This model could provide a proper frame for managers of health system in improving quality. Keywords: Quality model, Excellence model, Training centers, Primary cares, Iran

  1. Preliminary Study on Kano Model in the Conceptual Design Activities for Product Lifecycle Improvement

    Science.gov (United States)

    Fahrul Hassan, Mohd; Rahman, M. R. A.; Arifin, A. M. T.; Ismail, A. E.; Rasidi Ibrahim, M.; Zulafif Rahim, M.; Fauzi Ahmad, Md

    2017-08-01

    Product manufactured with short life cycle had only one major issue, it can lead to increasing volume of waste. Day by day, this untreated waste had consumed many landfill spaces, waiting for any possible alternatives. Lack of product recovery knowledge and recyclability features imprinted into product design are one of the main reason behind all this. Sustainable awareness aspect should not just be implied into people’s mind, but also onto product design. This paper presents a preliminary study on Kano model method in the conceptual design activities to improve product lifecycle. Kano model is a survey-type method, used to analyze and distinguished product qualities or features, also how the customers may have perceived them. Three important attributes of Kano model are performance, attractive and must-be. The proposed approach enables better understanding of customer requirements while providing a way for Kano model to be integrated into engineering design to improve product’s end-of-life. Further works will be continued to provide a better lifecycle option (increase percentage of reuse, remanufacture or recycle, whereby decrease percentage of waste) of a product using Kano model approach.

  2. Aware design models

    DEFF Research Database (Denmark)

    Tamke, Martin

    2015-01-01

    Appearing almost alive, a novel set of computational design models can become an active counterpart for architects in the design process. The ability to loop, sense and query and the integration of near real-time simulation provide these models with a depth and agility that allows for instant...... and informed feedback. Introducing the term "Aware models", the paper investigates how computational models become an enabler for a better informed architectural design practice, through the embedding of knowledge about constraints, behaviour and processes of formation and making into generative design models....... The inspection of several computational design projects in architectural research highlights three different types of awareness a model can possess and devises strategies to establish and finally design with aware models. This design practice is collaborative in nature and characterized by a bidirectional flow...

  3. Developing the DESCARTE Model: The Design of Case Study Research in Health Care.

    Science.gov (United States)

    Carolan, Clare M; Forbat, Liz; Smith, Annetta

    2016-04-01

    Case study is a long-established research tradition which predates the recent surge in mixed-methods research. Although a myriad of nuanced definitions of case study exist, seminal case study authors agree that the use of multiple data sources typify this research approach. The expansive case study literature demonstrates a lack of clarity and guidance in designing and reporting this approach to research. Informed by two reviews of the current health care literature, we posit that methodological description in case studies principally focuses on description of case study typology, which impedes the construction of methodologically clear and rigorous case studies. We draw from the case study and mixed-methods literature to develop the DESCARTE model as an innovative approach to the design, conduct, and reporting of case studies in health care. We examine how case study fits within the overall enterprise of qualitatively driven mixed-methods research, and the potential strengths of the model are considered. © The Author(s) 2015.

  4. Evaluating the effectiveness of Neuro web design model in business websites (observational study

    Directory of Open Access Journals (Sweden)

    Boshra Sedghi Shamir

    2016-06-01

    Full Text Available By combining Neuromarketing، social psychology and e-commerce، a new area has been added to the world of consumer neuroscience named Nero web design. The practical Neuro business web design model consists of 67 applicable and implementable techniques in business websites and has been gathered in three sequential phases: attraction، message delivery، and reshaping with the aim of negotiating to the visitor’s brain to increase the conversion rate on a business website. Eight websites have been implemented to evaluate the effectiveness of this model: A simple website without using the model، a complete website (using all 67 techniques in the model، and six other websites that differentiate in reshaping groups. The unique and targeted visitors for each websites obtained through internet advertisements. They became 957 new visitors altogether. In the period of two months of observational studying، Website heat maps that track the mouse movements of visitors، showed that visitors attracted to all parts of the complete website homepage particularly order form module but not so for the simple website. This reflects the success of attraction phase of the model. The results showed that the conversion rate of each of the seven model websites as compared to simple website is greatly high and even more than the international average conversion rate.

  5. Modeling, Analysis and Design of Feedback Operational Amplifier for Undergraduate Studies in Electrical Engineering

    Directory of Open Access Journals (Sweden)

    Han Yang

    2012-12-01

    Full Text Available The analog electronics is a challenging subject for undergraduate students in electrical engineering, due to the complex combination of many previous subjects, such as linear circuit analysis, signal and system, linear control theory and some sort of mathematics. This paper presents the modeling, analysis and design of the operational amplifier, which is used as benchmark system for analog electronics, for undergraduate studies in electrical engineering. Followed by the introduction of the operation amplifier circuit, the design of feedback network for the operational amplifier using MATLAB is presented. The bandwidth and sensitivity analysis for the feedback control loop are also discussed. In order to enhance the stability margin and dynamic characteristics of the operational amplifier, the lead compensator is designed for the feedback loop by adding capacitive component to the feedback resistive network. The presented analysis and design method of the operational amplifier by using MATLAB/SIMULINK can be highly effective to compliment the classroom teaching for circuit design courses for undergraduate studies in electrical engineering.

  6. JPL Thermal Design Modeling Philosophy and NASA-STD-7009 Standard for Models and Simulations - A Case Study

    Science.gov (United States)

    Avila, Arturo

    2011-01-01

    The Standard JPL thermal engineering practice prescribes worst-case methodologies for design. In this process, environmental and key uncertain thermal parameters (e.g., thermal blanket performance, interface conductance, optical properties) are stacked in a worst case fashion to yield the most hot- or cold-biased temperature. Thus, these simulations would represent the upper and lower bounds. This, effectively, represents JPL thermal design margin philosophy. Uncertainty in the margins and the absolute temperatures is usually estimated by sensitivity analyses and/or by comparing the worst-case results with "expected" results. Applicability of the analytical model for specific design purposes along with any temperature requirement violations are documented in peer and project design review material. In 2008, NASA released NASA-STD-7009, Standard for Models and Simulations. The scope of this standard covers the development and maintenance of models, the operation of simulations, the analysis of the results, training, recommended practices, the assessment of the Modeling and Simulation (M&S) credibility, and the reporting of the M&S results. The Mars Exploration Rover (MER) project thermal control system M&S activity was chosen as a case study determining whether JPL practice is in line with the standard and to identify areas of non-compliance. This paper summarizes the results and makes recommendations regarding the application of this standard to JPL thermal M&S practices.

  7. Studies in process modeling, design, monitoring, and control, with applications to polymer composites manufacturing

    Science.gov (United States)

    Srinivasagupta, Deepak

    2002-01-01

    High material and manufacturing costs have hindered the introduction of advanced polymer composite materials into mainstream civilian applications such as automotive. Even though high-fidelity models for several polymer composite manufacturing processes have become available over the past several years and offer significant benefits in manufacturing cost reduction, concerns about their inflexibility and maintenance has adversely affected their widespread usage. This research seeks to advance process modeling and design in polymer composites manufacturing to address these concerns. Other more general issues in measurement validation and distributed control are also addressed. Using a rigorous 3-D model of the injected pultrusion (IP) process validated recently, an algorithm was developed for process and equipment design with integrated economic, operability and environmental considerations. The optimum design promised enhanced throughput as well as reduction in the time and expenses of the current purely experimental approaches. Scale-up issues in IP were analyzed, and refinements to overcome some drawbacks in the model were suggested. The process model was then extended to simulate the co-injection resin transfer molding (CIRTM) process used for manufacture of foam-core sandwich composites. A 1-D isothermal model for real-time control was also developed. Process optimization using these models and experimental parametric studies increased the debond fracture toughness of sandwiches by 78% over current technology. To ensure the availability of validated measurements from process instrumentation, a novel in-situ sensor modeling approach to sensor validation was proposed. Both active and passive, time and frequency domain techniques were developed, and experimentally verified using temperature and flow sensors. A model-based dynamic estimator to predict the true measurement online was also validated. The effect of network communication delay on stability and control

  8. A modeling technique for active control design studies with application to spacecraft microvibrations.

    Science.gov (United States)

    Aglietti, G S; Gabriel, S B; Langley, R S; Rogers, E

    1997-10-01

    Microvibrations, at frequencies between 1 and 1000 Hz, generated by on board equipment, can propagate throughout a spacecraft structure and affect the performance of sensitive payloads. To investigate strategies to reduce these dynamic disturbances by means of active control systems, realistic yet simple structural models are necessary to represent the dynamics of the electromechanical system. In this paper a modeling technique which meets this requirement is presented, and the resulting mathematical model is used to develop some initial results on active control strategies. Attention is focused on a mass loaded panel subjected to point excitation sources, the objective being to minimize the displacement at an arbitrary output location. Piezoelectric patches acting as sensors and actuators are employed. The equations of motion are derived by using Lagrange's equation with vibration mode shapes as the Ritz functions. The number of sensors/actuators and their location is variable. The set of equations obtained is then transformed into state variables and some initial controller design studies are undertaken. These are based on standard linear systems optimal control theory where the resulting controller is implemented by a state observer. It is demonstrated that the proposed modeling technique is a feasible realistic basis for in-depth controller design/evaluation studies.

  9. Design of Photoreactor and Study of Modeling Parameters for Removal of Pesticides in Water: a Case Study of Malathion

    Directory of Open Access Journals (Sweden)

    Amit K. Sharma

    2011-02-01

    Full Text Available The design of photoreactor and its modeling parameters for removal of environmental pollutants in water are described. The work will provide the instructions to design of photoreactor with modeling parameters, and to allow these parameters to communicate degradation efficiency of the analyte in water samples. The modeling parameters are outlined by which the photoreactor can use UV source to degrade the composition of pollutant. The operation of degradation through photoreactor is applied to the study of degradation rate of pollutant i.e. malathion and the produced informative data at various time intervals also correlated with UV-vis spectrophotometry for the validation of results. The purpose of designed photoreactor is to know the best percentage degradability of pollutants at micro to nano gram levels using nanosemiconductor sensitizer like TiO2. Such designs promises the high impact at very low levels, less time consuming process, low consumable solvents and suit for field application purposes which focuses the merits of the designed photoreactor.

  10. Sustainable in-well vapor stripping: A design, analytical model, and pilot study for groundwater remediation.

    Science.gov (United States)

    Sutton, Patrick T; Ginn, Timothy R

    2014-12-15

    A sustainable in-well vapor stripping system is designed as a cost-effective alternative for remediation of shallow chlorinated solvent groundwater plumes. A solar-powered air compressor is used to inject air bubbles into a monitoring well to strip volatile organic compounds from a liquid to vapor phase while simultaneously inducing groundwater circulation around the well screen. An analytical model of the remediation process is developed to estimate contaminant mass flow and removal rates. The model was calibrated based on a one-day pilot study conducted in an existing monitoring well at a former dry cleaning site. According to the model, induced groundwater circulation at the study site increased the contaminant mass flow rate into the well by approximately two orders of magnitude relative to ambient conditions. Modeled estimates for 5h of pulsed air injection per day at the pilot study site indicated that the average effluent concentrations of dissolved tetrachloroethylene and trichloroethylene can be reduced by over 90% relative to the ambient concentrations. The results indicate that the system could be used cost-effectively as either a single- or multi-well point technology to substantially reduce the mass of dissolved chlorinated solvents in groundwater. Copyright © 2014 Elsevier B.V. All rights reserved.

  11. Succinate overproduction: A case study of computational strain design using a comprehensive Escherichia coli kinetic model

    Directory of Open Access Journals (Sweden)

    Ali eKhodayari

    2015-01-01

    Full Text Available Computational strain design prediction accuracy has been the focus for many recent efforts through the selective integration of kinetic information into metabolic models. In general, kinetic model prediction quality is determined by the range and scope of genetic and/or environmental perturbations used during parameterization. In this effort, we apply the k-OptForce procedure on a kinetic model of E. coli core metabolism constructed using the Ensemble Modeling (EM method and parameterized using multiple mutant strains data under aerobic respiration with glucose as the carbon source. Minimal interventions are identified that improve succinate yield under both aerobic and anaerobic conditions to test the fidelity of model predictions under both genetic and environmental perturbations. Under aerobic condition, k-OptForce identifies interventions that match existing experimental strategies pointing at a number of unexplored flux redirections such as routing glyoxylate flux through the glycerate metabolism to improve succinate yield. Many of the identified interventions rely on the kinetic descriptions and would not be discoverable by a purely stoichiometric description. In contrast, under fermentative (anaerobic conditions, k-OptForce fails to identify key interventions including up-regulation of anaplerotic reactions and elimination of competitive fermentative products. This is due to the fact that the pathways activated under anaerobic conditions were not properly parameterized as only aerobic flux data were used in the model construction. This study shed light on the importance of condition-specific model parameterization and provides insight onto how to augment kinetic models so as to correctly respond to multiple environmental perturbations.

  12. Succinate Overproduction: A Case Study of Computational Strain Design Using a Comprehensive Escherichia coli Kinetic Model.

    Science.gov (United States)

    Khodayari, Ali; Chowdhury, Anupam; Maranas, Costas D

    2014-01-01

    Computational strain-design prediction accuracy has been the focus for many recent efforts through the selective integration of kinetic information into metabolic models. In general, kinetic model prediction quality is determined by the range and scope of genetic and/or environmental perturbations used during parameterization. In this effort, we apply the k-OptForce procedure on a kinetic model of E. coli core metabolism constructed using the Ensemble Modeling (EM) method and parameterized using multiple mutant strains data under aerobic respiration with glucose as the carbon source. Minimal interventions are identified that improve succinate yield under both aerobic and anaerobic conditions to test the fidelity of model predictions under both genetic and environmental perturbations. Under aerobic condition, k-OptForce identifies interventions that match existing experimental strategies while pointing at a number of unexplored flux re-directions such as routing glyoxylate flux through the glycerate metabolism to improve succinate yield. Many of the identified interventions rely on the kinetic descriptions that would not be discoverable by a purely stoichiometric description. In contrast, under fermentative (anaerobic) condition, k-OptForce fails to identify key interventions including up-regulation of anaplerotic reactions and elimination of competitive fermentative products. This is due to the fact that the pathways activated under anaerobic condition were not properly parameterized as only aerobic flux data were used in the model construction. This study shed light on the importance of condition-specific model parameterization and provides insight on how to augment kinetic models so as to correctly respond to multiple environmental perturbations.

  13. Selecting appropriate animal models and experimental designs for endocrine disruptor research and testing studies.

    Science.gov (United States)

    Stokes, William S

    2004-01-01

    Evidence that chemicals in the environment may cause developmental and reproductive abnormalities in fish and wildlife by disrupting normal endocrine functions has increased concern about potential adverse human health effects from such chemicals. US laws have now been enacted that require the US Environmental Protection Agency (EPA) to develop and validate a screening program to identify chemicals in food and water with potential endocrine-disrupting activity. EPA subsequently proposed an Endocrine Disruptor Screening Program that uses in vitro and in vivo test systems to identify chemicals that may adversely affect humans and ecologically important animal species. However, the endocrine system can be readily modulated by many experimental factors, including diet and the genetic background of the selected animal strain or stock. It is therefore desirable to minimize or avoid factors that cause or contribute to experimental variation in endocrine disruptor research and testing studies. Standard laboratory animal diets contain high and variable levels of phytoestrogens, which can modulate physiologic and behavioral responses similar to both endogenous estrogen as well as exogenous estrogenic chemicals. Other studies have determined that some commonly used outbred mice and rats are less responsive to estrogenic substances than certain inbred mouse and rat strains for various estrogen-sensitive endpoints. It is therefore critical to select appropriate biological models and diets for endocrine disruptor studies that provide optimal sensitivity and specificity to accomplish the research or testing objectives. An introduction is provided to 11 other papers in this issue that review these and other important laboratory animal experimental design considerations in greater detail, and that review laboratory animal and in vitro models currently being used or evaluated for endocrine disruptor research and testing. Selection of appropriate animal models and experimental design

  14. Evaluating the effectiveness of Neuro web design model in business websites (observational study)

    National Research Council Canada - National Science Library

    Boshra Sedghi Shamir; Seyyed Ali Akbar Ahmadi

    2016-01-01

    .... The practical Neuro business web design model consists of 67 applicable and implementable techniques in business websites and has been gathered in three sequential phases: attraction، message delivery...

  15. A Model To Address Design Constraints of Training Delivered via Satellite. Study Number Eight.

    Science.gov (United States)

    Montler, Joseph; Geroy, Gary D.

    This document: summarizes how some companies are addressing the design constraints involved in using satellite technology to deliver training, presents a model aimed at examining cost effectiveness of the satellite option, and includes a guide to designing instructional materials for delivery by satellite. A survey of 39 organizations, 12…

  16. Design and Study of a Low-Cost Laboratory Model Digital Wind Power Meter

    Science.gov (United States)

    Radhakrishnan, Rugmini; Karthika, S.

    2010-01-01

    A vane-type low-cost laboratory model anemometer cum power meter is designed and constructed for measuring low wind energy created from accelerating fluids. The constructed anemometer is a device which records the electrical power obtained by the conversion of wind power using a wind sensor coupled to a DC motor. It is designed for its…

  17. Design and Study of a Low-Cost Laboratory Model Digital Wind Power Meter

    Science.gov (United States)

    Radhakrishnan, Rugmini; Karthika, S.

    2010-01-01

    A vane-type low-cost laboratory model anemometer cum power meter is designed and constructed for measuring low wind energy created from accelerating fluids. The constructed anemometer is a device which records the electrical power obtained by the conversion of wind power using a wind sensor coupled to a DC motor. It is designed for its…

  18. Fracture design modelling

    Energy Technology Data Exchange (ETDEWEB)

    Crichlow, H.B.; Crichlow, H.B. (ed.)

    1980-02-07

    A design tool is discussed whereby the various components that enter the design process of a hydraulic fracturing job are combined to provide a realistic appraisal of a stimulation job in the field. An interactive computer model is used to solve the problem numerically to obtain the effects of various parameters on the overall behavior of the system.

  19. An efficient model of an equipment loaded panel for active control design studies.

    Science.gov (United States)

    Aglietti, G S; Langley, R S; Rogers, E; Gabriel, S B

    2000-10-01

    An effective investigation of alternative control strategies for the reduction of vibration levels in satellite structures requires realistic, yet efficient, structural models to simulate the dynamics of the system. These models should include the effects of the sources, receivers, supporting structure, sensors, and actuators. In this paper, a modeling technique which meets these requirements is developed and some active control strategies are briefly investigated. The particular subject of investigation is an equipment-loaded panel and the equations of motion are derived using the Lagrange-Rayleigh-Ritz (LRR) approach. The various pieces of equipment on the panel are mounted on active or passive suspensions, and resonators are used to represent the internal dynamics of the mounted equipment. Control of the panel, which transmits vibrations from sources to receivers, is by means of piezoelectric patches and the excitation consists of dynamic loads acting on the equipment enclosures and/or directly on the panel. The control objective is to minimize the displacement at an arbitrary output location. The LRR model developed is verified against one produced by using the finite-element method. Finally, some initial controller design studies are undertaken to investigate and compare the effectiveness of different control strategies (e.g., minimization at the source, along the vibration path, or at the receiver).

  20. Strategies to design pyrazolyl urea derivatives for p38 kinase inhibition: a molecular modeling study

    Science.gov (United States)

    Kulkarni, Ravindra G.; Srivani, Palukuri; Achaiah, Garlapati; Sastry, G. Narahari

    2007-04-01

    The p38 protein kinase is a serine-threonine mitogen activated protein kinase, which plays an important role in inflammation and arthritis. A combined study of 3D-QSAR and molecular docking has been undertaken to explore the structural insights of pyrazolyl urea p38 kinase inhibitors. The 3D-QSAR studies involved comparative molecular field analysis (CoMFA) and comparative molecular similarity indices (CoMSIA). The best CoMFA model was derived from the atom fit alignment with a cross-validated r 2 ( q 2) value of 0.516 and conventional r 2 of 0.950, while the best CoMSIA model yielded a q 2 of 0.455 and r 2 of 0.979 (39 molecules in training set, 9 molecules in test set). The CoMFA and CoMSIA contour maps generated from these models provided inklings about the influence of interactive molecular fields in the space on the activity. GOLD, Sybyl (FlexX) and AutoDock docking protocols were exercised to explore the protein-inhibitor interactions. The integration of 3D-QSAR and molecular docking has proffered essential structural features of pyrazolyl urea inhibitors and also strategies to design new potent analogues with enhanced activity.

  1. A modelling breakthrough for market design analysis to test massive intermittent generation integration in markets results of selected OPTIMATE studies

    DEFF Research Database (Denmark)

    Beaude, Francois; Atayi, A.; Bourmaud, J.-Y.

    2013-01-01

    The OPTIMATE1 platform focuses on electricity system and market designs modelling in order to assess current and innovative designs in Europe. The current paper describes the results of the first validation studies' conducted with the tool. These studies deal with day-ahead market rules, load fle...

  2. Designing a Model of Organizational Agility: A Case Study of Ardabil Gas Company

    Directory of Open Access Journals (Sweden)

    Behrooz Razmi

    2015-06-01

    Full Text Available Organizational agility means the ability of every organization in sensation, perception, and prediction of available changes in the business environment. The importance of organizational agility in a competitive environment is nowadays widely recognized and accepted. The aim of this research was to design a unified theoretical model of organizational agility for Ardabil Gas Company based upon the theoretical principles of organizational agility proposed by Goldman (1995. Independent variables including organizational intelligence, organizational commitment, and organizational trust were considered as mediator variable and other four essential components of organizational agility such as forming of virtual participation valorize to humanistic knowledge and skills, change readiness, and customers answering were known as dependent variables of research. This is an applied, descriptive-correlation research, conducted by survey methodology. In this study, 568 employees, contractors, and subscribers of Ardabil Gas Company were chosen as the statistical population of the study. For the purpose of the study a questionnaire for data collection was used. Using Structural Equation Modeling (SEM, it is straightforward to test hypotheses of the equality of various correlation coefficients with any number of covariates across multiple groups. The gathered data was analyzed by using SPSS and LISREL software packages. The results of statistical analysis indicate that organizational trust has a significant positive relationship with organizational agility and organizational trust is the moderator of the relationship between technology intelligence and organizational agility and the relationship between organizational commitment and organizational agility.

  3. MATHEMATICAL MODEL FOR THE STUDY AND DESIGN OF A ROTARY-VANE GAS REFRIGERATION MACHINE

    Directory of Open Access Journals (Sweden)

    V. V. Trandafilov

    2016-08-01

    Full Text Available This paper presents a mathematical model of calculating the main parameters the operating cycle, rotary-vane gas refrigerating machine that affect installation, machine control and working processes occurring in it at the specified criteria. A procedure and a graphical method for the rotary-vane gas refrigerating machine (RVGRM are proposed. A parametric study of the main geometric variables and temperature variables on the thermal behavior of the system is analyzed. The model considers polytrope index for the compression and expansion in the chamber. Graphs of the pressure and temperature in the chamber of the angle of rotation of the output shaft are received. The possibility of inclusion in the cycle regenerative heat exchanger is appreciated. The change of the coefficient of performance machine after turning the cycle regenerative heat exchanger is analyzed. It is shown that the installation of a regenerator RVGRM cycle results in increased COP more than 30%. The simulation results show that the proposed model can be used to design and optimize gas refrigerator Stirling.

  4. Design Modelling Symposium 2015

    CERN Document Server

    Tamke, Martin; Gengnagel, Christoph; Faircloth, Billie; Scheurer, Fabian

    2015-01-01

    This book reflects and expands on the current trend in the building industry to understand, simulate and ultimately design buildings by taking into consideration the interlinked elements and forces that act on them. This approach overcomes the traditional, exclusive focus on building tasks, while posing new challenges in all areas of the industry from material and structural to the urban scale. Contributions from invited experts, papers and case studies provide the reader with a comprehensive overview of the field, as well as perspectives from related disciplines, such as computer science. The chapter authors were invited speakers at the 5th Symposium "Modelling Behaviour", which took place at the CITA in Copenhagen in September 2015.

  5. Computational study of a magnetic design to improve the diagnosis of malaria: 2D model

    Science.gov (United States)

    Vyas, Siddharth; Genis, Vladimir; Friedman, Gary

    2017-02-01

    This paper investigates the feasibility of a cost effective high gradient magnetic separation based device for the detection and identification of malaria parasites in a blood sample. The design utilizes magnetic properties of hemozoin present in malaria-infected red blood cells (mRBCs) in order to separate and concentrate them inside a microfluidic channel slide for easier examination under the microscope. The design consists of a rectangular microfluidic channel with multiple magnetic wires positioned on top of and underneath it along the length of the channel at a small angle with respect to the channel axis. Strong magnetic field gradients, produced by the wires, exert sufficient magnetic forces on the mRBCs in order to separate and concentrate them in a specific region small enough to fit within the microscope field of view at magnifications typically required to identify the malaria parasite type. The feasibility of the device is studied using a model where the trajectories of the mRBCs inside the channel are determined using first-order ordinary differential equations (ODEs) solved numerically using a multistep ODE solver available within MATLAB. The mRBCs trajectories reveal that it is possible to separate and concentrate the mRBCs in less than 5 min, even in cases of very low parasitemia (1-10 parasites/μL of blood) using blood sample volumes of around 3 μL employed today.

  6. Two-Stage Experimental Design for Dose–Response Modeling in Toxicology Studies

    OpenAIRE

    Wang, Kai; Yang, Feng; Porter, Dale W; Wu, Nianqiang

    2013-01-01

    The efficient design of experiments (i.e., selection of experimental doses and allocation of animals) is important to establishing dose–response relationships in toxicology studies. The proposed procedure for design of experiments is distinct from those in the literature because it is able to adequately accommodate the special features of the dose–response data, which include non-normality, variance heterogeneity, possibly nonlinearity of the dose–response curve, and data scarcity. The design...

  7. Biomembrane models and drug-biomembrane interaction studies: Involvement in drug design and development

    Directory of Open Access Journals (Sweden)

    R Pignatello

    2011-01-01

    Full Text Available Contact with many different biological membranes goes along the destiny of a drug after its systemic administration. From the circulating macrophage cells to the vessel endothelium, to more complex absorption barriers, the interaction of a biomolecule with these membranes largely affects its rate and time of biodistribution in the body and at the target sites. Therefore, investigating the phenomena occurring on the cell membranes, as well as their different interaction with drugs in the physiological or pathological conditions, is important to exploit the molecular basis of many diseases and to identify new potential therapeutic strategies. Of course, the complexity of the structure and functions of biological and cell membranes, has pushed researchers toward the proposition and validation of simpler two- and three-dimensional membrane models, whose utility and drawbacks will be discussed. This review also describes the analytical methods used to look at the interactions among bioactive compounds with biological membrane models, with a particular accent on the calorimetric techniques. These studies can be considered as a powerful tool for medicinal chemistry and pharmaceutical technology, in the steps of designing new drugs and optimizing the activity and safety profile of compounds already used in the therapy.

  8. AXIOLOGICAL MODEL OF INSTRUCTIONAL DESIGN

    Directory of Open Access Journals (Sweden)

    Takushevich I. A.

    2015-10-01

    Full Text Available The article presents instructional design as a new approach to the issue of developing value-oriented worldview. Scientific research and analysis led the author to summarize instructional design theory, broaden the definition of instructional design and apply it to instruction and learning in a new manner. The goal to build a pattern of instruction aimed at developing learners’ value-oriented worldview required the author to study the existing instructional design model, to analyse and generalize a number of monographs and articles devoted to the problem of building value systems and value orientations, and finally to investigate and apply the new knowledge to real life in the form of experiment. The work conducted brought the author to axiological model of instructional design, which consists of three dimensions: a linear sequence of the events from designing the instructional material to independent learning activities, interaction between a teacher and a learner, pace of learning and design. The article touches upon every dimension, level and stage of the model, describes and defines the procedures that take place on each of them, as well as suggests a possible way to visualize the model in a form of a sketch. The author also points out the advantages of using instructional design as an efficient and smart tool to organize learning and justifies the use of the new instructional design model in XXI century

  9. Dual Value Creation and Business Model Design: An Ethnographic Study of an Internationalizing NGO

    DEFF Research Database (Denmark)

    Turcan, Romeo V.

    This ethnographic research explores the process of business model design in the context of an NGO internationalizing to an emerging market. It contributes to the business model literature by investigating how this NGO - targeting multiple key stakeholders - was experimenting (1) with value propos...... proposition; (2) creating the value/promise; and (3) delivering the value. Theoretically the paper is grounded in the dynamic capability view of the firm providing venues for future research and implications for policy and practice....

  10. Molecular modeling study for inhibition mechanism of human chymase and its application in inhibitor design.

    Directory of Open Access Journals (Sweden)

    Mahreen Arooj

    Full Text Available Human chymase catalyzes the hydrolysis of peptide bonds. Three chymase inhibitors with very similar chemical structures but highly different inhibitory profiles towards the hydrolase function of chymase were selected with the aim of elucidating the origin of disparities in their biological activities. As a substrate (angiotensin-I bound crystal structure is not available, molecular docking was performed to dock the substrate into the active site. Molecular dynamics simulations of chymase complexes with inhibitors and substrate were performed to calculate the binding orientation of inhibitors and substrate as well as to characterize conformational changes in the active site. The results elucidate details of the 3D chymase structure as well as the importance of K40 in hydrolase function. Binding mode analysis showed that substitution of a heavier Cl atom at the phenyl ring of most active inhibitor produced a great deal of variation in its orientation causing the phosphinate group to interact strongly with residue K40. Dynamics simulations revealed the conformational variation in region of V36-F41 upon substrate and inhibitor binding induced a shift in the location of K40 thus changing its interactions with them. Chymase complexes with the most active compound and substrate were used for development of a hybrid pharmacophore model which was applied in databases screening. Finally, hits which bound well at the active site, exhibited key interactions and favorable electronic properties were identified as possible inhibitors for chymase. This study not only elucidates inhibitory mechanism of chymase inhibitors but also provides key structural insights which will aid in the rational design of novel potent inhibitors of the enzyme. In general, the strategy applied in the current study could be a promising computational approach and may be generally applicable to drug design for other enzymes.

  11. Model Reduction in Chemical Engineering: Case studies applied to process analysis, design and operation

    NARCIS (Netherlands)

    Dorneanu, B.

    2011-01-01

    During the last decades, models have become widely used for supporting a broad range of chemical engineering activities, such as product and process design and development, process monitoring and control, real time optimization of plant operation or supply chain management. Although tremendous

  12. Collaborative Environments for the Learning of Design: A Model and a Case Study in Domotics

    Science.gov (United States)

    Bravo, Crescencio; Redondo, Miguel A.; Ortega, Manuel; Verdejo, M. Felisa

    2006-01-01

    Design plays a central role in a range of subjects at different educational levels. Students have to acquire the knowledge necessary for the execution of tasks that enable them to construct an artefact or model that can be tested by simulation and that satisfies some requirements and verifies some constraints. They achieve this by means of a…

  13. A case study on robust optimal experimental design for model calibration of ω-Transaminase

    DEFF Research Database (Denmark)

    Daele, Timothy, Van; Van Hauwermeiren, Daan; Ringborg, Rolf Hoffmeyer

    and measurement errors. Since the latter was not provided, a conservative standard deviation of 5% was assumed. The confidence analysis yielded that only two (Vr and Kac) out of five parameters were reliable estimates, which means that model predictions and decisions based on them are highly uncertain. The reason...... the experimental space. However, it is expected that more informative experiments can be designed to increase the confidence of the parameter estimates. Therefore, we apply Optimal Experimental Design (OED) to the calibrated model of Shin and Kim (1998). The total number of samples was retained to allow fair......” parameter values are not known before finishing the model calibration. However, it is important that the chosen parameter values are close to the real parameter values, otherwise the OED can possibly yield non-informative experiments. To counter this problem, one can use robust OED. The idea of robust OED...

  14. Computational Design Modelling : Proceedings of the Design Modelling Symposium

    CERN Document Server

    Kilian, Axel; Palz, Norbert; Scheurer, Fabian

    2012-01-01

    This book publishes the peer-reviewed proceeding of the third Design Modeling Symposium Berlin . The conference constitutes a platform for dialogue on experimental practice and research within the field of computationally informed architectural design. More than 60 leading experts the computational processes within the field of computationally informed architectural design to develop a broader and less exotic building practice that bears more subtle but powerful traces of the complex tool set and approaches we have developed and studied over recent years. The outcome are new strategies for a reasonable and innovative implementation of digital potential in truly innovative and radical design guided by both responsibility towards processes and the consequences they initiate.

  15. Care Models of eHealth Services: A Case Study on the Design of a Business Model for an Online Precare Service.

    Science.gov (United States)

    van Meeuwen, Dorine Pd; van Walt Meijer, Quirine J; Simonse, Lianne Wl

    2015-03-24

    With a growing population of health care clients in the future, the organization of high-quality and cost-effective service providing becomes an increasing challenge. New online eHealth services are proposed as innovative options for the future. Yet, a major barrier to these services appears to be the lack of new business model designs. Although design efforts generally result in visual models, no such artifacts have been found in the literature on business model design. This paper investigates business model design in eHealth service practices from a design perspective. It adopts a research by design approach and seeks to unravel what characteristics of business models determine an online service and what are important value exchanges between health professionals and clients. The objective of the study was to analyze the construction of care models in-depth, framing the essential elements of a business model, and design a new care model that structures these elements for the particular context of an online pre-care service in practice. This research employs a qualitative method of an in-depth case study in which different perspectives on constructing a care model are investigated. Data are collected by using the visual business modeling toolkit, designed to cocreate and visualize the business model. The cocreated models are transcribed and analyzed per actor perspective, transactions, and value attributes. We revealed eight new actors in the business model for providing the service. Essential actors are: the intermediary network coordinator connecting companies, the service dedicated information technology specialists, and the service dedicated health specialist. In the transactions for every service providing we found a certain type of contract, such as a license contract and service contracts for precare services and software products. In addition to the efficiency, quality, and convenience, important value attributes appeared to be: timelines, privacy and

  16. Towards global experimental design using Bayesian networks : case studies on modeling sensory satiation

    NARCIS (Netherlands)

    Phan, V.A.

    2013-01-01

    Food science problems are complex. Scientists may be able to capture more of the complexity of an investigated theme if they were able to integrate related studies. Unfortunately, individual studies are usually not designed to allow such integration,  and the common statistical methods cannot

  17. Glucosamine-6-phosphate synthase, a novel target for antifungal agents. Molecular modelling studies in drug design.

    Science.gov (United States)

    Wojciechowski, Marek; Milewski, Sławomir; Mazerski, Jan; Borowski, Edward

    2005-01-01

    Fungal infections are a growing problem in contemporary medicine, yet only a few antifungal agents are used in clinical practice. In our laboratory we proposed the enzyme L-glutamine: D-fructose-6-phosphate amidotransferase (EC 2.6.1.16) as a new target for antifungals. The structure of this enzyme consists of two domains, N-terminal and C-terminal ones, catalysing glutamine hydrolysis and sugar-phosphate isomerisation, respectively. In our laboratory a series of potent selective inhibitors of GlcN-6-P synthase have been designed and synthesised. One group of these compounds, including the most studied N3-(4-methoxyfumaroyl)-l-2,3-diaminopropanoic acid (FMDP), behave like glutamine analogs acting as active-site-directed inactivators, blocking the N-terminal, glutamine-binding domain of the enzyme. The second group of GlcN-6-P synthase inhibitors mimic the transition state of the reaction taking place in the C-terminal sugar isomerising domain. Surprisingly, in spite of the fact that glutamine is the source of nitrogen for a number of enzymes it turned out that the glutamine analogue FMDP and its derivatives are selective against GlcN-6-P synthase and they do not block other enzymes, even belonging to the same family of glutamine amidotransferases. Our molecular modelling studies of this phenomenon revealed that even within the family of related enzymes substantial differences may exist in the geometry of the active site. In the case of the glutamine amidotransferase family the glutamine binding site of GlcN-6-P synthase fits a different region of the glutamine conformational space than other amidotransferases. Detailed analysis of the interaction pattern for the best known, so far, inhibitor of the sugar isomerising domain, namely 2-amino-2-deoxy-D-glucitol-6-phosphate (ADGP), allowed us to suggest changes in the structure of the inhibitor that should improve the interaction pattern. The novel ligand was designed and synthesised. Biological experiments confirmed

  18. An online corpus of UML Design Models : construction and empirical studies

    NARCIS (Netherlands)

    Karasneh, B.H.A.

    2016-01-01

    We address two problems in Software Engineering. The first problem is how to assess the severity of software defects? The second problem we address is that of studying software designs. Automated support for assessing the severity of software defects helps human developers to perform this task more

  19. An online corpus of UML Design Models : construction and empirical studies

    NARCIS (Netherlands)

    Karasneh, B.H.A.

    2016-01-01

    We address two problems in Software Engineering. The first problem is how to assess the severity of software defects? The second problem we address is that of studying software designs. Automated support for assessing the severity of software defects helps human developers to perform this task more

  20. Developing a User-process Model for Designing Menu-based Interfaces: An Exploratory Study.

    Science.gov (United States)

    Ju, Boryung; Gluck, Myke

    2003-01-01

    The purpose of this study was to organize menu items based on a user-process model and implement a new version of current software for enhancing usability of interfaces. A user-process model was developed, drawn from actual users' understanding of their goals and strategies to solve their information needs by using Dervin's Sense-Making Theory…

  1. Using ProModel as a simulation tools to assist plant layout design and planning: Case study plastic packaging factory

    Directory of Open Access Journals (Sweden)

    Pochamarn Tearwattanarattikal

    2008-01-01

    Full Text Available This study is about the application of a Simulation Model to assist decision making on expanding capacity and plant layout design and planning. The plant layout design concept is performed first to create the physical layouts then the simulation model used to test the capability of plant to meet various demand forecast scena. The study employed ProModel package as a tool, using the model to compare the performances in term of % utilization, characteristics of WIP and ability to meet due date. The verification and validation stages were perform before running the scenarios. The model runs daily production and then the capacity constraint resources defined by % utilization. The expanding capacity policy can be extra shift-working hours or increasing the number of machines. After expanding capacity solutions are found, the physical layout is selected based on the criterion of space available for WIP and easy flow of material.

  2. MODELING OF PETROLEUM ENGINEERS DESIGN-TECHNOLOGICAL COMPETENCE FORMING IN PHYSICAL-MATHEMATICAL DISCIPLINES STUDYING PROCESS

    Directory of Open Access Journals (Sweden)

    Ilsiyar Mingatinovna Zaripova

    2014-01-01

    Full Text Available The essence and contents of students’ project technical competence as a synthesis of design and technical competencies, including special knowledge, abilities, skills and personal qualities which are necessary for their future professional duties effective implementation, particular, for engineering projects successful implementation, requiring technical calculations performing and abilities, allowing to operate in professional activity effectively, to be guided in work situations correctly, to adapt to changing industry and the necessary conditions are revealed in the article. The main blocks of design technological competences’ formation model of future petroleum engineers in the process of mathematics and the natural cycle disciplines’ teaching are presented: The theoretical-methodological, functional-target, technological, methodical and criterion-evaluative, the whole combination of which is aimed at students’ advanced entering in their future profession as petroleum engineers and emotional attachment to the results of their professional activity."

  3. Modeling external events in the three-level analysis of multiple-baseline across-participants designs: a simulation study.

    Science.gov (United States)

    Moeyaert, Mariola; Ugille, Maaike; Ferron, John M; Beretvas, S Natasha; Van den Noortgate, Wim

    2013-06-01

    In this study, we focus on a three-level meta-analysis for combining data from studies using multiple-baseline across-participants designs. A complicating factor in such designs is that results might be biased if the dependent variable is affected by not explicitly modeled external events, such as the illness of a teacher, an exciting class activity, or the presence of a foreign observer. In multiple-baseline designs, external effects can become apparent if they simultaneously have an effect on the outcome score(s) of the participants within a study. This study presents a method for adjusting the three-level model to external events and evaluates the appropriateness of the modified model. Therefore, we use a simulation study, and we illustrate the new approach with real data sets. The results indicate that ignoring an external event effect results in biased estimates of the treatment effects, especially when there is only a small number of studies and measurement occasions involved. The mean squared error, as well as the standard error and coverage proportion of the effect estimates, is improved with the modified model. Moreover, the adjusted model results in less biased variance estimates. If there is no external event effect, we find no differences in results between the modified and unmodified models.

  4. Simulation Programs for Ph.D. Study of Analysis, Modeling and Optimum Design of Solar Domestic Hot Water Systems

    DEFF Research Database (Denmark)

    Qin, Lin

    1999-01-01

    The design of solar domestic hot water system is a complex process, due to characteristics inherent in solar heating technology. Recently, computer simulation has become a widely used technique to improve the understanding of the thermal processes in such systems. This report presents the detailed...... programs or units that were developed in the Ph.D study of " Analysis, Modeling and Optimum Design of Solar Domestic Hot Water Systems"....

  5. Does Implementation Follow Design? A Case Study of a Workplace Health Promotion Program Using the 4-S Program Design and the PIPE Impact Metric Evaluation Models.

    Science.gov (United States)

    Äikäs, Antti Hermanni; Pronk, Nicolaas P; Hirvensalo, Mirja Hannele; Absetz, Pilvikki

    2017-08-01

    The aim of this study was to describe the content of a multiyear market-based workplace health promotion (WHP) program and to evaluate design and implementation processes in a real-world setting. Data was collected from the databases of the employer and the service provider. It was classified using the 4-S (Size, Scope, Scalability, and Sustainability) and PIPE Impact Metric (Penetration, Implementation) models. Data analysis utilized both qualitative and quantitative methods. Program design covered well the evidence-informed best practices except for clear path toward sustainability, cooperation with occupational health care, and support from middle-management supervisors. The penetration rate among participants was high (99%) and majority (81%) of services were implemented as designed. Study findings indicate that WHP market would benefit the use of evidence-based design principles and tendentious decisions to anticipate a long-term implementation process already during the planning phase.

  6. A model-based meta-analysis of monoclonal antibody pharmacokinetics to guide optimal first-in-human study design.

    Science.gov (United States)

    Davda, Jasmine P; Dodds, Michael G; Gibbs, Megan A; Wisdom, Wendy; Gibbs, John

    2014-01-01

    The objectives of this retrospective analysis were (1) to characterize the population pharmacokinetics (popPK) of four different monoclonal antibodies (mAbs) in a combined analysis of individual data collected during first-in-human (FIH) studies and (2) to provide a scientific rationale for prospective design of FIH studies with mAbs. The data set was composed of 171 subjects contributing a total of 2716 mAb serum concentrations, following intravenous (IV) and subcutaneous (SC) doses. mAb PK was described by an open 2-compartment model with first-order elimination from the central compartment and a depot compartment with first-order absorption. Parameter values obtained from the popPK model were further used to generate optimal sampling times for a single dose study. A robust fit to the combined data from four mAbs was obtained using the 2-compartment model. Population parameter estimates for systemic clearance and central volume of distribution were 0.20 L/day and 3.6 L with intersubject variability of 31% and 34%, respectively. The random residual error was 14%. Differences (> 2-fold) in PK parameters were not apparent across mAbs. Rich designs (22 samples/subject), minimal designs for popPK (5 samples/subject), and optimal designs for non-compartmental analysis (NCA) and popPK (10 samples/subject) were examined by stochastic simulation and estimation. Single-dose PK studies for linear mAbs executed using the optimal designs are expected to yield high-quality model estimates, and accurate capture of NCA estimations. This model-based meta-analysis has determined typical popPK values for four mAbs with linear elimination and enabled prospective optimization of FIH study designs, potentially improving the efficiency of FIH studies for this class of therapeutics.

  7. Ligand modeling and design

    Energy Technology Data Exchange (ETDEWEB)

    Hay, B.P. [Pacific Northwest National Lab., Richland, WA (United States)

    1997-10-01

    The purpose of this work is to develop and implement a molecular design basis for selecting organic ligands that would be used in the cost-effective removal of specific radionuclides from nuclear waste streams. Organic ligands with metal ion specificity are critical components in the development of solvent extraction and ion exchange processes that are highly selective for targeted radionuclides. The traditional approach to the development of such ligands involves lengthy programs of organic synthesis and testing, which in the absence of reliable methods for screening compounds before synthesis, results in wasted research effort. The author`s approach breaks down and simplifies this costly process with the aid of computer-based molecular modeling techniques. Commercial software for organic molecular modeling is being configured to examine the interactions between organic ligands and metal ions, yielding an inexpensive, commercially or readily available computational tool that can be used to predict the structures and energies of ligand-metal complexes. Users will be able to correlate the large body of existing experimental data on structure, solution binding affinity, and metal ion selectivity to develop structural design criteria. These criteria will provide a basis for selecting ligands that can be implemented in separations technologies through collaboration with other DOE national laboratories and private industry. The initial focus will be to select ether-based ligands that can be applied to the recovery and concentration of the alkali and alkaline earth metal ions including cesium, strontium, and radium.

  8. Axial-Flow Compressor Performance Prediction in Design and Off-Design Conditions through 1-D and 3-D Modeling and Experimental Study

    Directory of Open Access Journals (Sweden)

    Ahmad Peyvan

    2016-01-01

    Full Text Available In this study, the main objective is to develop a one dimensional model to predict design and off design performance of an operational axial flow compressor by considering the whole gas turbine assembly. The design and off-design performance of a single stage axial compressor are predicted through 1D and 3D modeling. In one dimensional model the mass, momentum and energy conservation equations and ideal gas equation of state are solved in mean line at three axial stations including rotor inlet, rotor outlet and stator outlet. The total to total efficiency and pressure ratio are forecasted using the compressor geometry, inlet stagnation temperature and stagnation pressure, the mass flow rate and the rotational speed of the rotor, and the available empirical correlation predicting the losses. By changing the mass flow rate while the rotational speed is fixed, characteristic curves of the compressor are obtained. The 3D modeling is accomplished with CFD method to verify one dimensional code at non-running line conditions. By defining the three-dimensional geometry of the compressor and the boundary conditions coinciding with one dimensional model for the numerical solver, axial compressor behavior is predicted for various mass flow rates in different rotational speeds. Experimental data are obtained from tests of the axial compressor of a gas turbine engine in Sharif University gas turbine laboratory and consequently the running line is attained. As a result, the two important extremities of compressor performance including surge and choking conditions are obtained through 1D and 3D modeling. Moreover, by comparing the results of one-dimensional and three-dimensional models with experimental results, good agreement is observed. The maximum differences of pressure ratio and isentropic efficiency of one dimensional modeling with experimental results are 2.1 and 3.4 percent, respectively.

  9. Experimental study of fission counter design optimization with a simplified analytical model of performance

    Energy Technology Data Exchange (ETDEWEB)

    Valentine, K.H.; De Lorenzo, J.T.; Clay, W.T.; Pare, V.K.; Guerrant, G.C.; Burns, R.S.

    1979-12-01

    Trends inferred from this study of fission counter design confirm previously known relationships between design variables and counter performance. Most important is the proved existence of an optimum electrode spacing for a specific design that increases with electrode area and decreases with gamma dose rate. The PD product also has an optimum value, with low values being limited by the presence of electronic noise and high values by enhanced gamma pileup. Conventional 50-..cap omega.. signal cables do not always provide the best performance, particularly for large-area counters that have high interelectrode capacitances and operate in high gamma background. Values as low as 16.7 ..cap omega.. yield an improvement of as much as 20%. The performance of a counter closely follows the E/P versus drift velocity characteristic of its gas mixture, and is superior for fill gases having higher electron drift velocities. The optimum filter time constant of the counting channel depends on the gamma background dose rate. At low gamma levels, when electronic noise dominates, longer filter time constants give better signal-to-noise ratios. Counters with shorter collection times more effectively suppress the gamma pileup at high dose rates, and filters with higher break-frequencies process the faster pulses more effectively. Another conclusion from this study is that the usable neutron sensitivity per gram of neutron-sensitive material is a monotonically decreasing function of electrode area. These sensitivity losses can be minimized for high-sensitivity fission counters by use of neutron-sensitive material with low intrinsic alpha activity (such as electromagnetically enriched uranium), as well as by careful specification of the major design variables.

  10. Slurry reactor design studies

    Energy Technology Data Exchange (ETDEWEB)

    Fox, J.M.; Degen, B.D.; Cady, G.; Deslate, F.D.; Summers, R.L. (Bechtel Group, Inc., San Francisco, CA (USA)); Akgerman, A. (Texas A and M Univ., College Station, TX (USA)); Smith, J.M. (California Univ., Davis, CA (USA))

    1990-06-01

    The objective of these studies was to perform a realistic evaluation of the relative costs of tublar-fixed-bed and slurry reactors for methanol, mixed alcohols and Fischer-Tropsch syntheses under conditions where they would realistically be expected to operate. The slurry Fischer-Tropsch reactor was, therefore, operated at low H{sub 2}/CO ratio on gas directly from a Shell gasifier. The fixed-bed reactor was operated on 2.0 H{sub 2}/CO ratio gas after adjustment by shift and CO{sub 2} removal. Every attempt was made to give each reactor the benefit of its optimum design condition and correlations were developed to extend the models beyond the range of the experimental pilot plant data. For the methanol design, comparisons were made for a recycle plant with high methanol yield, this being the standard design condition. It is recognized that this is not necessarily the optimum application for the slurry reactor, which is being proposed for a once-through operation, coproducing methanol and power. Consideration is also given to the applicability of the slurry reactor to mixed alcohols, based on conditions provided by Lurgi for an Octamix{trademark} plant using their standard tubular-fixed reactor technology. 7 figs., 26 tabs.

  11. [How does collective violence shape the health status of its victims? Conceptual model and design of the ISAVIC study].

    Science.gov (United States)

    Larizgoitia, Itziar; Izarzugaza, Isabel; Markez, Iñaki; Fernández, Itziar; Iraurgi, Ioseba; Larizgoitia, Arantza; Ballesteros, Javier; Fernández-Liria, Alberto; Moreno, Florentino; Retolaza, Ander; Páez, Darío; Martín-Beristaín, Carlos; Alonso, Jordi

    2011-01-01

    Epidemiologic research on collective violence (violence exerted by and within groups in pursuit of political, social or economic goals) is very scarce despite its growing recognition as a major public health issue. This paper describes the conceptual model and design of one of the first research studies conducted in Spain aiming to assess the impact of collective violence in the health status of its victims (study known as ISAVIC, based on its Spanish title Impacto en la SAlud de la VIolencia Colectiva). Starting with a comprehensive but non-systematic review of the literature, the authors describe the sequelae likely produced by collective violence and propose a conceptual model to explain the nature of the relationships between collective violence and health status. The conceptual model informed the ISAVIC study design and its measurement instruments. The possible sequelae of collective violence, in the physical, emotional and social dimensions of health, are described. Also, the review distinguishes the likely impact in primary and secondary victims, as well as the interplay with the social environment. The mixed methodological design of the ISAVIC study supports the coherence of the conceptual model described. The ISAVIC study suggests that collective violence may affect the main dimensions of the health status of its victims, in intimate relation to the societal factors where it operates. It is necessary to validate these results with new studies. Copyright © 2010 SESPAS. Published by Elsevier Espana. All rights reserved.

  12. A Newly Designed Anal Fistula Plug: Clinicopathological Study in an Experimental Iatrogenic Fistula Model

    Science.gov (United States)

    Aikawa, Masayasu; Miyazawa, Mitsuo; Okada, Katsuya; Akimoto, Naoe; Koyama, Isamu; Yamaguchi, Shigeki; Ikada, Yoshito

    2013-01-01

    We report on a clinicopathologic study in an animal model of treatment with a new bioabsorbable polymer plug (BAPP). Over a 2-week period, 6 porcine models, which each had 4 anal fistulae, were created using Blake drains. The pigs were divided into 2 groups: the BAPP-treatment group (n = 12 fistulae) and the control group (n = 12 fistulae). Two weeks later, the pigs were humanely killed, and the perianal sites were excised and examined with gross and pathologic studies. Each fistula in the BAPP group was completely cured. In the pathologic study, the treatment sites had little disarray, few defects in the muscular layer, and small numbers of inflammatory cells. The control group had a significantly greater number of inflammatory cells and microabscesses than the BAPP group. The newly developed BAPP reduced the infection and induced good healing in anal fistulae. The BAPP may be a useful new device for the clinical treatment of anal fistulae. PMID:23701146

  13. Simulation programs for ph.D. study of analysis, modeling and optimum design of solar domestic hot water systems

    Energy Technology Data Exchange (ETDEWEB)

    Lin Qin

    1998-12-31

    The design of solar domestic hot water (DHW) systems is a complex process, due to characteristics inherent in the solar heating technology. Recently, computer simulation has become a widely used technique to improve the understanding of the thermal processes in such systems. One of the main objects of the Ph.D. study of `Analysis, Modelling and optimum Design of Solar Domestic Hot Water Systems` is to develop and verify programs for carrying out the simulation and evaluation of the dynamic performance of solar DHW systems. During this study, simulation programs for hot water distribution networks and for certain types of solar DHW systems were developed. (au)

  14. Study of pseudoelastic systems for the design of complex passive dampers: static analysis and modeling

    Science.gov (United States)

    Nespoli, Adelaide; Rigamonti, Daniela; Riva, Marco; Villa, Elena; Passaretti, Francesca

    2016-10-01

    This work presents an experimental and numerical analysis of several parallel systems of NiTi pseudoelastic wires. Standard tensile tests were accomplished to evaluate the global damping capacity, the energy dissipated per cycle and the maximum attenuated force in a static condition. Besides, a numerical model was implemented to predict the damping response of more complex pseudoelastic arrangements. It was found a damping capacity upper limit of 0.09 regardless the number and the length of the NiTi components. In addition, it was found that the energy dissipated per cycle is related to the strain and to the number of the NiTi components; furthermore, the system composed of NiTi wires with different length allows for an elastic region that is related to the numbers of wires and that presents a modulation of the stiffness. Finally, the proposed numerical model allows a precise design of complex pseudoelastic combinations as it is able to represent the rhombohedral characteristic.

  15. Designing satisfaction studies

    DEFF Research Database (Denmark)

    Kristensen, Kai; Eskildsen, Jacob Kjær

    2007-01-01

    In the effect sampling method, presentation of researcher, the intro text, the order of questions in the questionnaire along with the number of categories in the rating scale is tested in relation to the design of satisfaction studies. Based on the analyses specific recommendations for designing...... satisfaction studies are given....

  16. The Scope of Design Studying

    Institute of Scientific and Technical Information of China (English)

    JIN Yin; Ren Wenying

    2007-01-01

    This article trys to discuss the scope of design studying in two fields.Firstly, design has three meanings: wide design, art design and industrial design.Secondly, design studying has five contents: cultural, philosophical, methodological, produced and marketable trends.

  17. A Multidisciplinary Design Optimization Model for AUV Synthetic Conceptual Design

    Institute of Scientific and Technical Information of China (English)

    BU Guang-zhi; ZHANG Yu-wen

    2006-01-01

    Autonomous undersea vehicle (AUV) is a typical complex engineering system. This paper studies the disciplines and coupled variables in AUV design with multidisciplinary design optimization (M DO) methods. The framework of AUV synthetic conceptual design is described first, and then a model with collaborative optimization is studied. At last,an example is given to verify the validity and efficiency of MDO in AUV synthetic conceptual design.

  18. Student Models of Instructional Design

    Science.gov (United States)

    Magliaro, Susan G.; Shambaugh, Neal

    2006-01-01

    Mental models are one way that humans represent knowledge (Markman, 1999). Instructional design (ID) is a conceptual model for developing instruction and typically includes analysis, design, development, implementation, and evaluation (i.e., ADDIE model). ID, however, has been viewed differently by practicing teachers and instructional designers…

  19. A study of the isobutane dehydrogenation in a porous membrane catalytic reactor: design, use and modelling

    Energy Technology Data Exchange (ETDEWEB)

    Casanave, D.

    1996-01-26

    The aim of this study was to set up and model a catalytic fixed-bed membrane reactor for the isobutane dehydrogenation. The catalyst, developed at Catalysis Research Institute (IRC), was a silicalite-supported Pt-based catalyst. Their catalytic performances (activity, selectivity, stability) where found better adapted to the membrane reactor, when compared with commercial Pt or Cr based catalysts. The kinetic study of the reaction has been performed in a differential reactor and led to the determination of a kinetic law, suitable when the catalyst is used near thermodynamic equilibrium. The mass transfer mechanisms were determined in meso-porous and microporous membranes through both permeability and gas mixtures (iC{sub 4}/H{sub 2}/N{sub 2}) separation measurements. For the meso-porous {gamma}-alumina, the mass transfer is ensured by a Knudsen diffusion mechanism which can compete with surface diffusion for condensable gas like isobutane. The resulting permselectivity H{sub 2}/iC4 of this membrane is low ({approx} 4). For the microporous zeolite membrane, molecular sieving occurs due to steric hindrance, leading to higher permselectivity {approx}14. Catalyst/membrane associations were compared in terms of isobutane dehydrogenation performances, for both types of membranes (meso-porous and microporous) and for two different reactor configurations (co-current and counter-current sweep gas flow). The best experimental results were obtained with the zeolite membrane, when sweeping the outer compartment in a co-current flow. The equilibrium displacement observed with the {gamma}-alumina membrane was lower and mainly due to a dilution effect of the reaction mixture by the sweep gas. A mathematical model was developed, which correctly describes all the experimental results obtained with the zeolite membrane, when the co-current mode is used. (Abstract Truncated)

  20. Ligand modeling and design

    Energy Technology Data Exchange (ETDEWEB)

    Hay, B. [Pacific Northwest Lab., Richland, WA (United States)

    1996-10-01

    The purpose of this work is to develop and implement a molecular design basis for selecting organic ligands that would be used tin applications for the cost-effective removal of specific radionuclides from nuclear waste streams.

  1. Design and data analysis 1 study design

    Directory of Open Access Journals (Sweden)

    Karthik Suresh

    2012-01-01

    Full Text Available This article is intended to give the reader guidance in evaluating different study designs used in medical research for better scientific quality, reliability and validity of their research. This article explains three main types of study designs with understanding examples. Care and caution with skills and experience needed to design suitable studies and appropriate design coupled with reliable sampling techniques and appropriate statistical analysis, supported by clear objectives with decent communication of the findings, are essential for good research.

  2. Co-designing business models

    DEFF Research Database (Denmark)

    Gudiksen, Sune Klok

    2015-01-01

    with diverse perspectives internally (managers, marketers, designer etc.) and externally (potential end-users/customers, potential partners and experts on special issues) meet in order to collaboratively design business models, and what might be gained and be problematic about such a situation. In regards...... in a system, product or service for a particular end-user. In this dissertation, co-design and design games enter a new frontier - business models - and move towards being a part of a broader innovation agenda. The research deals with a double concern: First, the transfer of co-design and the subfield design...... games into business model experimentation to investigate how this might be useful in this new application domain. Second, investigate what can be added to the transferring field co-design, hereunder especially design games. The research into this double concern is conducted through an approach assembled...

  3. Solid model design simplification

    Energy Technology Data Exchange (ETDEWEB)

    Ames, A.L.; Rivera, J.J.; Webb, A.J.; Hensinger, D.M.

    1997-12-01

    This paper documents an investigation of approaches to improving the quality of Pro/Engineer-created solid model data for use by downstream applications. The investigation identified a number of sources of problems caused by deficiencies in Pro/Engineer`s geometric engine, and developed prototype software capable of detecting many of these problems and guiding users towards simplified, useable models. The prototype software was tested using Sandia production solid models, and provided significant leverage in attacking the simplification problem.

  4. Optimal design for nonlinear response models

    CERN Document Server

    Fedorov, Valerii V

    2013-01-01

    Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors' many years of experience in academia and the pharmaceutical industry. While the focus is on nonlinear models, the book begins with an explanation of the key ideas, using linear models as examples. Applying the linearization in the parameter space, it then covers nonlinear models and locally optimal designs as well as minimax, optimal on average, and Bayesian designs. The authors also discuss ada

  5. Numerical Modeling of a Thermal-Hydraulic Loop and Test Section Design for Heat Transfer Studies in Supercritical Fluids

    Science.gov (United States)

    McGuire, Daniel

    A numerical tool for the simulation of the thermal dynamics of pipe networks with heat transfer has been developed with the novel capability of modeling supercritical fluids. The tool was developed to support the design and deployment of two thermal-hydraulic loops at Carleton University for the purpose of heat transfer studies in supercritical and near-critical fluids. First, the system was characterized based on its defining features; the characteristic length of the flow path is orders of magnitude larger than the other characteristic lengths that define the system's geometry; the behaviour of the working fluid in the supercritical thermodynamic state. An analysis of the transient thermal behaviour of the model's domains is then performed to determine the accuracy and range of validity of the modeling approach for simulating the transient thermal behaviour of a thermal-hydraulic loop. Preliminary designs of three test section geometries, for the purpose of heat transfer studies, are presented in support of the overall design of the Carleton supercritical thermal-hydraulic loops. A 7-rod-bundle, annular and tubular geometries are developed with support from the new numerical tool. Materials capable of meeting the experimental requirements while operating in supercritical water are determined. The necessary geometries to satisfy the experimental goals are then developed based on the material characteristics and predicted heat transfer behaviour from previous simulation results. An initial safety analysis is performed on the test section designs, where they are evaluated against the ASME Boiler, Pressure Vessel, and Pressure Piping Code standard, required for safe operation and certification.

  6. A Conceptual Design Model for CBT Development: A NATO Case Study

    Science.gov (United States)

    Kok, Ayse

    2014-01-01

    CBT (computer-based training) can benefit from the modern multimedia tools combined with network capabilities to overcame traditional education. The objective of this paper is focused on CBT development to improve strategic decision-making with regard to air command and control system for NATO staff in virtual environment. A conceptual design for…

  7. How to develop, validate, and compare clinical prediction models involving radiological parameters: Study design and statistical methods

    Energy Technology Data Exchange (ETDEWEB)

    Han, Kyung Hwa; Choi, Byoung Wook [Dept. of Radiology, and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul (Korea, Republic of); Song, Ki Jun [Dept. of Biostatistics and Medical Informatics, Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2016-06-15

    Clinical prediction models are developed to calculate estimates of the probability of the presence/occurrence or future course of a particular prognostic or diagnostic outcome from multiple clinical or non-clinical parameters. Radiologic imaging techniques are being developed for accurate detection and early diagnosis of disease, which will eventually affect patient outcomes. Hence, results obtained by radiological means, especially diagnostic imaging, are frequently incorporated into a clinical prediction model as important predictive parameters, and the performance of the prediction model may improve in both diagnostic and prognostic settings. This article explains in a conceptual manner the overall process of developing and validating a clinical prediction model involving radiological parameters in relation to the study design and statistical methods. Collection of a raw dataset; selection of an appropriate statistical model; predictor selection; evaluation of model performance using a calibration plot, Hosmer-Lemeshow test and c-index; internal and external validation; comparison of different models using c-index, net reclassification improvement, and integrated discrimination improvement; and a method to create an easy-to-use prediction score system will be addressed. This article may serve as a practical methodological reference for clinical researchers.

  8. Designing a Curriculum Model for the Teaching of the Bible in UK Jewish Secondary Schools: A Case Study

    Science.gov (United States)

    Kohn, Eli

    2012-01-01

    This paper describes the process of designing a curriculum model for Bible teaching in UK Jewish secondary schools. This model was designed over the period 2008-2010 by a team of curriculum specialists from the Jewish Curriculum Partnership UK in collaboration with a group of teachers from Jewish secondary schools. The paper first outlines the…

  9. A global low order spectral model designed for climate sensitivity studies

    Science.gov (United States)

    Hanna, A. F.; Stevens, D. E.

    1984-01-01

    A two level, global, spectral model using pressure as a vertical coordinate is developed. The system of equations describing the model is nonlinear and quasi-geostrophic. A moisture budget is calculated in the lower layer only with moist convective adjustment between the two layers. The mechanical forcing of topography is introduced as a lower boundary vertical velocity. Solar forcing is specified assuming a daily mean zenith angle. On land and sea ice surfaces a steady state thermal energy equation is solved to calculate the surface temperature. Over the oceans the sea surface temperatures are prescribed from the climatological average of January. The model is integrated to simulate the January climate.

  10. A Robust Design Applicability Model

    DEFF Research Database (Denmark)

    Ebro, Martin; Lars, Krogstie; Howard, Thomas J.

    2015-01-01

    This paper introduces a model for assessing the applicability of Robust Design (RD) in a project or organisation. The intention of the Robust Design Applicability Model (RDAM) is to provide support for decisions by engineering management considering the relevant level of RD activities. The applic...

  11. Study Designs and Evaluation Models for Emergency Department Public Health Research

    OpenAIRE

    Broderick, Kerry B.; Ranney, Megan L.; Vaca, Federico E.; D’Onofrio, Gail; Rothman, Richard E.; Rhodes, Karin V; Becker, Bruce; Haukoos, Jason S.

    2009-01-01

    Public health research requires sound design and thoughtful consideration of potential biases that may influence the validity of results. It also requires careful implementation of protocols and procedures that are likely to translate from the research environment to actual clinical practice. This article is the product of a breakout session from the 2009 Academic Emergency Medicine consensus conference entitled “Public Health in the ED: Screening, Surveillance, and Intervention” and serves t...

  12. CONCURRENT ENGINEERING MODEL (CEM ANALYSIS ON LOGISTICS DESIGN PARAMETERS – A CASE STUDY

    Directory of Open Access Journals (Sweden)

    J.S. Gnanasekaran

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: Logistics engineering can be divided into internal or in-plant logistics and external manufacturing logistics. Internal (in-plant logistics include material handling, warehousing, and storage systems, while external manufacturing logistics include transportation. Both must be integrated to minimise costs at a competitive level of service. For example, plant layout and production planning must consider internal logistics. The design decisions are made in the early phases of product design, and development will have a significant effect over future manufacturing and logistical activities. In this paper, a methodology is developed and presented to minimise the design cycle time of any manufacturing firm, including their suppliers, and to maximise the whole system’s effectiveness.

    AFRIKAANSE OPSOMMING: Logistieke ingenieurswese kan verdeel word in interne of binne-aanleg logistiek en eksterne vervaardigingslogistiek. Interne (binne-aanleg logistiek behels materiaalhantering, berging en voorraadhoudingsisteme, terwyl eksterne vervaardigingslogistiek vervoer insluit. Die fasette moet geintegreer wees om koste te minimiseer by ‘n mededingende diensvlak. So byvoorbeeld moet die uitleg van ‘n aanleg en produksiebeplanning interne logistiek in aanmerking neem. Die ontwerpbesluite word geneem in die beginstadium van die produkontwerp en ontwikkeling sal ‘n betekenisvolle invloed hê op toekomstige vervaardigings- en logistieke aktiwiteite. In hierdie artikel word ‘n metodologie ontwikkel en aangebied om die ontwerpsiklustyd van enige vervaardigingsonderneming te minimiseer met inagneming van die leweransiers om sodoende die totale sisteem se effektiwiteit te maksimiseer.

  13. Modeling Tool Advances Rotorcraft Design

    Science.gov (United States)

    2007-01-01

    Continuum Dynamics Inc. (CDI), founded in 1979, specializes in advanced engineering services, including fluid dynamic modeling and analysis for aeronautics research. The company has completed a number of SBIR research projects with NASA, including early rotorcraft work done through Langley Research Center, but more recently, out of Ames Research Center. NASA Small Business Innovation Research (SBIR) grants on helicopter wake modeling resulted in the Comprehensive Hierarchical Aeromechanics Rotorcraft Model (CHARM), a tool for studying helicopter and tiltrotor unsteady free wake modeling, including distributed and integrated loads, and performance prediction. Application of the software code in a blade redesign program for Carson Helicopters, of Perkasie, Pennsylvania, increased the payload and cruise speeds of its S-61 helicopter. Follow-on development resulted in a $24 million revenue increase for Sikorsky Aircraft Corporation, of Stratford, Connecticut, as part of the company's rotor design efforts. Now under continuous development for more than 25 years, CHARM models the complete aerodynamics and dynamics of rotorcraft in general flight conditions. CHARM has been used to model a broad spectrum of rotorcraft attributes, including performance, blade loading, blade-vortex interaction noise, air flow fields, and hub loads. The highly accurate software is currently in use by all major rotorcraft manufacturers, NASA, the U.S. Army, and the U.S. Navy.

  14. Comparing Dutch Case management care models for people with dementia and their caregivers: The design of the COMPAS study

    Directory of Open Access Journals (Sweden)

    MacNeil Vroomen Janet

    2012-05-01

    Full Text Available Abstract Background Dementia care in the Netherlands is shifting from fragmented, ad hoc care to more coordinated and personalised care. Case management contributes to this shift. The linkage model and a combination of intensive case management and joint agency care models were selected based on their emerging prominence in the Netherlands. It is unclear if these different forms of case management are more effective than usual care in improving or preserving the functioning and well-being at the patient and caregiver level and at the societal cost. The objective of this article is to describe the design of a study comparing these two case management care models against usual care. Clinical and cost outcomes are investigated while care processes and the facilitators and barriers for implementation of these models are considered. Design Mixed methods include a prospective, observational, controlled, cohort study among persons with dementia and their primary informal caregiver in regions of the Netherlands with and without case management including a qualitative process evaluation. Inclusion criteria for the cohort study are: community-dwelling individuals with a dementia diagnosis who are not terminally-ill or anticipate admission to a nursing home within 6 months and with an informal caregiver who speaks fluent Dutch. Person with dementia-informal caregiver dyads are followed for two years. The primary outcome measure is the Neuropsychiatric Inventory for the people with dementia and the General Health Questionnaire for their caregivers. Secondary outcomes include: quality of life and needs assessment in both persons with dementia and caregivers, activity of daily living, competence of care, and number of crises. Costs are measured from a societal perspective using cost diaries. Process indicators measure the quality of care from the participant’s perspective. The qualitative study uses purposive sampling methods to ensure a wide variation of

  15. MULTI-WORLD MECHANISM FOR MODELING EVOLUTIONARY DESIGN PROCESS FROM CONCEPTUAL DESIGN TO DETAILED DESIGN

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A multi-world mechanism is developed for modeling evolutionary design process from conceptual design to detailed design. In this mechanism, the evolutionary design database is represented by a sequence of worlds corresponding to the design descriptions at different design stages. In each world, only the differences with its ancestor world are recorded. When the design descriptions in one world are changed, these changes are then propagated to its descendant worlds automatically. Case study is conducted to show the effectiveness of this evolutionary design database model.

  16. Designing a Care Pathway Model – A Case Study of the Outpatient Total Hip Arthroplasty Care Pathway

    Directory of Open Access Journals (Sweden)

    Robin I. Oosterholt

    2017-03-01

    Full Text Available Introduction: Although the clinical attributes of total hip arthroplasty (THA care pathways have been thoroughly researched, a detailed understanding of the equally important organisational attributes is still lacking. The aim of this article is to contribute with a model of the outpatient THA care pathway that depicts how the care team should be organised to enable patient discharge on the day of surgery. Theory: The outpatient THA care pathway enables patients to be discharged on the day of surgery, short- ening the length of stay and intensifying the provision and organisation of care. We utilise visual care modelling to construct a visual design of the organisation of the care pathway. Methods: An embedded case study was conducted of the outpatient THA care pathway at a teaching hospital in the Netherlands. The data were collected using a visual care modelling toolkit in 16 semi- structured interviews. Problems and inefficiencies in the care pathway were identified and addressed in the iterative design process. Results: The results are two visual models of the most critical phases of the outpatient THA care pathway: diagnosis & preparation (1 and mobilisation & discharge (4. The results show the care team composition, critical value exchanges, and sequence that enable patient discharge on the day of surgery. Conclusion: The design addressed existing problems and is an optimisation of the case hospital’s pathway. The network of actors consists of the patient (1, radiologist (1, anaesthetist (1, nurse specialist (1, pharmacist (1, orthopaedic surgeon (1,4, physiotherapist (1,4, nurse (4, doctor (4 and patient applica- tion (1,4. The critical value exchanges include patient preparation (mental and practical, patient education, aligned care team, efficient sequence of value exchanges, early patient mobilisation, flexible availability of the physiotherapist, functional discharge criteria, joint decision making and availability of the care team.

  17. Air Force Reusable Booster System: A Quick-look, Design Focused Modeling and Cost Analysis Study

    Science.gov (United States)

    Zapata, Edgar

    2011-01-01

    This paper presents a method and an initial analysis of the costs of a reusable booster system (RBS) as envisioned by the US Department of Defense (DoD) and numerous initiatives that form the concept of Operationally Responsive Space (ORS). This paper leverages the knowledge gained from decades of experience with the semi-reusable NASA Space Shuttle to understand how the costs of a military next generation semi-reusable space transport might behave in the real world - and how it might be made as affordable as desired. The NASA Space Shuttle had a semi-expendable booster, that being the reusable Solid Rocket MotorslBoosters (SRMlSRB) and the expendable cryogenic External Tank (ET), with a reusable cargo and crew capable orbiter. This paper will explore DoD concepts that invert this architectural arrangement, using a reusable booster plane that flies back to base soon after launch, with the in-space elements of the launch system being the expendable portions. Cost estimating in the earliest stages of any potential, large scale program has limited usefulness. As a result, the emphasis here is on developing an approach, a structure, and the basic concepts that could continue to be matured as the program gains knowledge. Where cost estimates are provided, these results by necessity carry many caveats and assumptions, and this analysis becomes more about ways in which drivers of costs for diverse scenarios can be better understood. The paper is informed throughout with a design-for-cost philosophy whereby the design and technology features of the proposed RBS (who and what, the "architecture") are taken as linked at the hip to a desire to perform a certain mission (where and when), and together these inform the cost, responsiveness, performance and sustainability (how) of the system. Concepts for developing, acquiring, producing or operating the system will be shown for their inextricable relationship to the "architecture" of the system, and how these too relate to costs

  18. A comparison of adaptive sampling designs and binary spatial models: A simulation study using a census of Bromus inermis

    Science.gov (United States)

    Irvine, Kathryn M.; Thornton, Jamie; Backus, Vickie M.; Hohmann, Matthew G.; Lehnhoff, Erik A.; Maxwell, Bruce D.; Michels, Kurt; Rew, Lisa

    2013-01-01

    Commonly in environmental and ecological studies, species distribution data are recorded as presence or absence throughout a spatial domain of interest. Field based studies typically collect observations by sampling a subset of the spatial domain. We consider the effects of six different adaptive and two non-adaptive sampling designs and choice of three binary models on both predictions to unsampled locations and parameter estimation of the regression coefficients (species–environment relationships). Our simulation study is unique compared to others to date in that we virtually sample a true known spatial distribution of a nonindigenous plant species, Bromus inermis. The census of B. inermis provides a good example of a species distribution that is both sparsely (1.9 % prevalence) and patchily distributed. We find that modeling the spatial correlation using a random effect with an intrinsic Gaussian conditionally autoregressive prior distribution was equivalent or superior to Bayesian autologistic regression in terms of predicting to un-sampled areas when strip adaptive cluster sampling was used to survey B. inermis. However, inferences about the relationships between B. inermis presence and environmental predictors differed between the two spatial binary models. The strip adaptive cluster designs we investigate provided a significant advantage in terms of Markov chain Monte Carlo chain convergence when trying to model a sparsely distributed species across a large area. In general, there was little difference in the choice of neighborhood, although the adaptive king was preferred when transects were randomly placed throughout the spatial domain.

  19. Crowd Modeling in Military Simulations: Requirements Analysis, Survey, and Design Study

    Science.gov (United States)

    2003-04-01

    agents. Databases for the searches included WorldCat , InfoTrac, Ovid, Google, Proceedings First, and Psyclnfo. Articles and books were evaluated on...resolution human character visual models 44 Figure 12. Quantico Combat Town terrain database 44 Figure 13. Lower fidelity crowd behavior 45 Figure 14...levels of fidelity. The Quantico Combat Town terrain database , illustrated in Figure 12, was used as a virtual venue for the experiment. Figure 12

  20. Using Diversity Modeling for Instructional Design.

    Science.gov (United States)

    Pulsinelli, Alesha; Roubie, Cynthia

    2001-01-01

    The project DEVISE case study shows how diversity modeling can be used as a powerful design tool. Designers used performance-centered design techniques to create a virtual learning environment in which students with learning disabilities would be more fully supported with an interface that meets their needs. (AEF)

  1. Generation of subject-specific, dynamic, multisegment ankle and foot models to improve orthotic design: a feasibility study

    Directory of Open Access Journals (Sweden)

    Oosterwaal Michiel

    2011-11-01

    Full Text Available Abstract Background Currently, custom foot and ankle orthosis prescription and design tend to be based on traditional techniques, which can result in devices which vary greatly between clinicians and repeat prescription. The use of computational models of the foot may give further insight in the biomechanical effects of these devices and allow a more standardised approach to be taken to their design, however due to the complexity of the foot the models must be highly detailed and dynamic. Methods/Design Functional and anatomical datasets will be collected in a multicentre study from 10 healthy participants and 15 patients requiring orthotic devices. The patient group will include individuals with metarsalgia, flexible flat foot and drop foot. Each participant will undergo a clinical foot function assessment, 3D surface scans of the foot under different loading conditions, and detailed gait analysis including kinematic, kinetic, muscle activity and plantar pressure measurements in both barefoot and shod conditions. Following this each participant will undergo computed tomography (CT imaging of their foot and ankle under a range of loads and positions while plantar pressures are recorded. A further subgroup of participants will undergo magnetic resonance imaging (MRI of the foot and ankle. Imaging data will be segmented to derive the geometry of the bones and the orientation of the joint axes. Insertion points of muscles and ligaments will be determined from the MRI and CT-scans and soft tissue material properties computed from the loaded CT data in combination with the plantar pressure measurements. Gait analysis data will be used to drive the models and in combination with the 3D surface scans for scaling purposes. Predicted plantar pressures and muscle activation patterns predicted from the models will be compared to determine the validity of the models. Discussion This protocol will lead to the generation of unique datasets which will be used

  2. Kinetic and Performance Studies of the Regeneration Phase of Model Pt/Ba/Rh NOx Traps for Design and Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Michael Harold; Vemuri Balakotaiah

    2010-05-31

    In this project a combined experimental and theoretical approach was taken to advance our understanding of lean NOx trap (LNT) technology. Fundamental kinetics studies were carried out of model LNT catalysts containing variable loadings of precious metals (Pt, Rh), and storage components (BaO, CeO{sub 2}). The Temporal Analysis of Products (TAP) reactor provided transient data under well-characterized conditions for both powder and monolith catalysts, enabling the identification of key reaction pathways and estimation of the corresponding kinetic parameters. The performance of model NOx storage and reduction (NSR) monolith catalysts were evaluated in a bench scale NOx trap using synthetic exhaust, with attention placed on the effect of the pulse timing and composition on the instantaneous and cycle-averaged product distributions. From these experiments we formulated a global model that predicts the main spatio-temporal features of the LNT and a mechanistic-based microkinetic models that incorporates a detailed understanding of the chemistry and predicts more detailed selectivity features of the LNT. The NOx trap models were used to determine its ability to simulate bench-scale data and ultimately to evaluate alternative LNT designs and operating strategies. The four-year project led to the training of several doctoral students and the dissemination of the findings as 47 presentations in conferences, catalysis societies, and academic departments as well 23 manuscripts in peer-reviewed journals. A condensed review of NOx storage and reduction was published in an encyclopedia of technology.

  3. Feasibility study of solid oxide fuel cell engines integrated with sprinter gas turbines: Modeling, design and control

    Science.gov (United States)

    Jia, Zhenzhong; Sun, Jing; Dobbs, Herb; King, Joel

    2015-02-01

    Conventional recuperating solid oxide fuel cell (SOFC)/gas turbine (GT) system suffers from its poor dynamic capability and load following performance. To meet the fast, safe and efficient load following requirements for mobile applications, a sprinter SOFC/GT system concept is proposed in this paper. In the proposed system, an SOFC stack operating at fairly constant temperature provides the baseline power with high efficiency while the fast dynamic capability of the GT-generator is fully explored for fast dynamic load following. System design and control studies have been conducted by using an SOFC/GT system model consisting of experimentally-verified component models. In particular, through analysis of the steady-state simulation results, an SOFC operation strategy is proposed to maintain fairly constant SOFC power (less than 2% power variation) and temperature (less than 2 K temperature variation) over the entire load range. A system design procedure well-suited to the proposed system has also been developed to help determining component sizes and the reference steady-state operation line. In addition, control analysis has been studied for both steady-state and transient operations. Simulation results suggest that the proposed system holds the promise to achieve fast and safe transient operations by taking full advantage of the fast dynamics of the GT-generator.

  4. COMPUTER MODELING IN CAMPUS DESIGN. CASE STUDY AT DUKE UNIVERSITY. FINAL PAPER.

    Science.gov (United States)

    MATTOX, ROBERT F.

    IN A PILOT STUDY CONDUCTED TO PROVIDE BETTER INFORMATION FOR CAMPUS PLANNING, COMPUTER PROGRAMS WERE DEVELOPED TO ANALYZE DATA COLLECTED FROM STUDENT DIARIES. AREAS OF CONCERN INCLUDED--(1) TIME SPENT IN A SPECIFIC ACTIVITY, (2) TRAFFIC ACTIVITIES AND RELATED VARIABLES (COSTS, ETC.), AND (5) PROJECTION OF FUTURE CAMPUS ACTIVITY-SPACE RELATIONSHIPS…

  5. Simulation studies as designed experiments: the comparison of penalized regression models in the "large p, small n" setting.

    Science.gov (United States)

    Chaibub Neto, Elias; Bare, J Christopher; Margolin, Adam A

    2014-01-01

    New algorithms are continuously proposed in computational biology. Performance evaluation of novel methods is important in practice. Nonetheless, the field experiences a lack of rigorous methodology aimed to systematically and objectively evaluate competing approaches. Simulation studies are frequently used to show that a particular method outperforms another. Often times, however, simulation studies are not well designed, and it is hard to characterize the particular conditions under which different methods perform better. In this paper we propose the adoption of well established techniques in the design of computer and physical experiments for developing effective simulation studies. By following best practices in planning of experiments we are better able to understand the strengths and weaknesses of competing algorithms leading to more informed decisions about which method to use for a particular task. We illustrate the application of our proposed simulation framework with a detailed comparison of the ridge-regression, lasso and elastic-net algorithms in a large scale study investigating the effects on predictive performance of sample size, number of features, true model sparsity, signal-to-noise ratio, and feature correlation, in situations where the number of covariates is usually much larger than sample size. Analysis of data sets containing tens of thousands of features but only a few hundred samples is nowadays routine in computational biology, where "omics" features such as gene expression, copy number variation and sequence data are frequently used in the predictive modeling of complex phenotypes such as anticancer drug response. The penalized regression approaches investigated in this study are popular choices in this setting and our simulations corroborate well established results concerning the conditions under which each one of these methods is expected to perform best while providing several novel insights.

  6. Simulation studies as designed experiments: the comparison of penalized regression models in the "large p, small n" setting.

    Directory of Open Access Journals (Sweden)

    Elias Chaibub Neto

    Full Text Available New algorithms are continuously proposed in computational biology. Performance evaluation of novel methods is important in practice. Nonetheless, the field experiences a lack of rigorous methodology aimed to systematically and objectively evaluate competing approaches. Simulation studies are frequently used to show that a particular method outperforms another. Often times, however, simulation studies are not well designed, and it is hard to characterize the particular conditions under which different methods perform better. In this paper we propose the adoption of well established techniques in the design of computer and physical experiments for developing effective simulation studies. By following best practices in planning of experiments we are better able to understand the strengths and weaknesses of competing algorithms leading to more informed decisions about which method to use for a particular task. We illustrate the application of our proposed simulation framework with a detailed comparison of the ridge-regression, lasso and elastic-net algorithms in a large scale study investigating the effects on predictive performance of sample size, number of features, true model sparsity, signal-to-noise ratio, and feature correlation, in situations where the number of covariates is usually much larger than sample size. Analysis of data sets containing tens of thousands of features but only a few hundred samples is nowadays routine in computational biology, where "omics" features such as gene expression, copy number variation and sequence data are frequently used in the predictive modeling of complex phenotypes such as anticancer drug response. The penalized regression approaches investigated in this study are popular choices in this setting and our simulations corroborate well established results concerning the conditions under which each one of these methods is expected to perform best while providing several novel insights.

  7. Benefits of statistical molecular design, covariance analysis, and reference models in QSAR: a case study on acetylcholinesterase.

    Science.gov (United States)

    Andersson, C David; Hillgren, J Mikael; Lindgren, Cecilia; Qian, Weixing; Akfur, Christine; Berg, Lotta; Ekström, Fredrik; Linusson, Anna

    2015-03-01

    Scientific disciplines such as medicinal- and environmental chemistry, pharmacology, and toxicology deal with the questions related to the effects small organic compounds exhort on biological targets and the compounds' physicochemical properties responsible for these effects. A common strategy in this endeavor is to establish structure-activity relationships (SARs). The aim of this work was to illustrate benefits of performing a statistical molecular design (SMD) and proper statistical analysis of the molecules' properties before SAR and quantitative structure-activity relationship (QSAR) analysis. Our SMD followed by synthesis yielded a set of inhibitors of the enzyme acetylcholinesterase (AChE) that had very few inherent dependencies between the substructures in the molecules. If such dependencies exist, they cause severe errors in SAR interpretation and predictions by QSAR-models, and leave a set of molecules less suitable for future decision-making. In our study, SAR- and QSAR models could show which molecular sub-structures and physicochemical features that were advantageous for the AChE inhibition. Finally, the QSAR model was used for the prediction of the inhibition of AChE by an external prediction set of molecules. The accuracy of these predictions was asserted by statistical significance tests and by comparisons to simple but relevant reference models.

  8. DEVELOPMENT OF AN EXPERIMENTAL TEST BED DESIGNATED FOR MODEL STUDIES OF AERODYNAMICS OF PREMISES USING METHOD OF DIGITAL FLOW VISUALIZATION

    Directory of Open Access Journals (Sweden)

    Varapaev Vladimir Nikolaevich

    2012-12-01

    Full Text Available In the article, the authors present their findings generated at the laboratory of aerodynamic and aero-acoustic testing of structural units of MGSU. The authors provide information about the principle of operation and a brief description of the experimental test bed designated for the physical research of patterns of air flows arising inside building premises of various geometric shapes. The authors also demonstrate the basic parameters of the test bed, the principle of operation of its recording devices and some of its characteristics. The test bed is designated for the identification of characteristics of three-dimensional flows of models under research and for the verification of results of numerical studies. The measurement bed has advanced measurement and registration units. The management principle is based on the method of digital flow visualization, PIV method and Doppler flow meter implemented in the LDA anemometer. The test stand generates two or three component vector fields of turbulent gas flow velocities. It may be applicable to the study of liquids in case of research of hydraulics-related problems. Some results of the flow study are provided in the article, as well.

  9. Modeling Languages Refine Vehicle Design

    Science.gov (United States)

    2009-01-01

    Cincinnati, Ohio s TechnoSoft Inc. is a leading provider of object-oriented modeling and simulation technology used for commercial and defense applications. With funding from Small Business Innovation Research (SBIR) contracts issued by Langley Research Center, the company continued development on its adaptive modeling language, or AML, originally created for the U.S. Air Force. TechnoSoft then created what is now known as its Integrated Design and Engineering Analysis Environment, or IDEA, which can be used to design a variety of vehicles and machinery. IDEA's customers include clients in green industries, such as designers for power plant exhaust filtration systems and wind turbines.

  10. A Reflexive Model for Teaching Instructional Design.

    Science.gov (United States)

    Shambaugh, Neal; Magliaro, Susan

    2001-01-01

    Documents a five-year study of two instructors who collaborated on formally studying their teaching of a master's level instructional design course. Outlines their views on learning, teaching, and instructional design (ID), describes the ID course, and explains the reflexive instructional model used, in which the teachers examined their teaching…

  11. Product model structure for generalized optimal design

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The framework of the generalized optimization product model with the core of network- and tree-hierarchical structure is advanced to improve the characteristics of the generalized optimal design. Based on the proposed node-repetition technique, a network-hierarchical structure is united with the tree-hierarchical structure to facilitate the modeling of serialization and combination products. The criteria for product decomposition are investigated. Seven tree nodes are defined for the construction of a general product model, and their modeling properties are studied in detail. The developed product modeling system is applied and examined successfully in the modeling practice of the generalized optimal design for a hydraulic excavator.

  12. Object Oriented Modeling and Design

    Science.gov (United States)

    Shaykhian, Gholam Ali

    2007-01-01

    The Object Oriented Modeling and Design seminar is intended for software professionals and students, it covers the concepts and a language-independent graphical notation that can be used to analyze problem requirements, and design a solution to the problem. The seminar discusses the three kinds of object-oriented models class, state, and interaction. The class model represents the static structure of a system, the state model describes the aspects of a system that change over time as well as control behavior and the interaction model describes how objects collaborate to achieve overall results. Existing knowledge of object oriented programming may benefit the learning of modeling and good design. Specific expectations are: Create a class model, Read, recognize, and describe a class model, Describe association and link, Show abstract classes used with multiple inheritance, Explain metadata, reification and constraints, Group classes into a package, Read, recognize, and describe a state model, Explain states and transitions, Read, recognize, and describe interaction model, Explain Use cases and use case relationships, Show concurrency in activity diagram, Object interactions in sequence diagram.

  13. Seal design alternatives study

    Energy Technology Data Exchange (ETDEWEB)

    Van Sambeek, L.L. [RE/SPEC Inc., Rapid City, SD (US); Luo, D.D.; Lin, M.S.; Ostrowski, W.; Oyenuga, D. [Parsons Brinckerhoff Quade & Douglas, Inc., San Francisco, CA (US)

    1993-06-01

    This report presents the results from a study of various sealing alternatives for the WIPP sealing system. Overall, the sealing system has the purpose of reducing to the extent possible the potential for fluids (either gas or liquid) from entering or leaving the repository. The sealing system is divided into three subsystems: drift and panel seals within the repository horizon, shaft seals in each of the four shafts, and borehole seals. Alternatives to the baseline configuration for the WIPP seal system design included evaluating different geometries and schedules for seal component installations and the use of different materials for seal components. Order-of-magnitude costs for the various alternatives were prepared as part of the study. Firm recommendations are not presented, but the advantages and disadvantages of the alternatives are discussed. Technical information deficiencies are identified and studies are outlined which can provide required information.

  14. Threat modeling designing for security

    CERN Document Server

    Shostack, Adam

    2014-01-01

    Adam Shostack is responsible for security development lifecycle threat modeling at Microsoft and is one of a handful of threat modeling experts in the world. Now, he is sharing his considerable expertise into this unique book. With pages of specific actionable advice, he details how to build better security into the design of systems, software, or services from the outset. You'll explore various threat modeling approaches, find out how to test your designs against threats, and learn effective ways to address threats that have been validated at Microsoft and other top companies. Systems secur

  15. Numerical modelling of the CHEMREC black liquor gasification process. Conceptual design study of the burner in a pilot gasification reactor

    Energy Technology Data Exchange (ETDEWEB)

    Marklund, Magnus

    2001-02-01

    The work presented in this report is done in order to develop a simplified CFD model for Chemrec's pressurised black liquor gasification process. This process is presently under development and will have a number of advantages compared to conventional processes for black liquor recovery. The main goal with this work has been to get qualitative information on influence of burner design for the gas flow in the gasification reactor. Gasification of black liquor is a very complex process. The liquor is composed of a number of different substances and the composition may vary considerably between liquors originating from different mills and even for black liquor from a single process. When a black liquor droplet is gasified it loses its organic material to produce combustible gases by three stages of conversion: Drying, pyrolysis and char gasification. In the end of the conversion only an inorganic smelt remains (ideally). The aim is to get this smelt to form a protective layer, against corrosion and heat, on the reactor walls. Due to the complexity of gasification of black liquor some simplifications had to be made in order to develop a CFD model for the preliminary design of the gasification reactor. Instead of modelling droplets in detail, generating gas by gasification, sources were placed in a prescribed volume where gasification (mainly drying and pyrolysis) of the black liquor droplets was assumed to occur. Source terms for the energy and momentum equations, consistent with the mass source distribution, were derived from the corresponding control volume equations by assuming a symmetric outflow of gas from the droplets and a uniform degree of conversion of reactive components in the droplets. A particle transport model was also used in order to study trajectories from droplets entering the reactor. The resulting model has been implemented in a commercial finite volume code (AEA-CFX) through customised Fortran subroutines. The advantages with this simple

  16. Traditional courtyard houses as a model for sustainable design: A case study on BWhs mesoclimate of Iran

    Directory of Open Access Journals (Sweden)

    Farzaneh Soflaei

    2017-09-01

    Full Text Available Manifestations of sustainable design require renewable resources, impact the environment minimally, and connect people with the natural environment. This article is aimed to investigate the concept of Iranian traditional courtyards, as microclimate modifiers, for sustainable building design in hot-arid regions. To this end, a quantitative field survey is conducted to analyze various physical elements including the orientation, dimensions and proportions of enclosed and open spaces, physical bodies (opaque walls, and transparent surfaces (openings as well as natural elements (water and soil in nine valuable Iranian traditional courtyard houses from BWhs mesoclimate. In conclusion, all survey-based data are integrated to propose a physical–environmental design model for courtyards in this region. Proposed model can be generalized to all design cases, where located in BWhs mesoclimate with similar environmental conditions.

  17. Optimal Control Design with Limited Model Information

    CERN Document Server

    Farokhi, F; Johansson, K H

    2011-01-01

    We introduce the family of limited model information control design methods, which construct controllers by accessing the plant's model in a constrained way, according to a given design graph. We investigate the achievable closed-loop performance of discrete-time linear time-invariant plants under a separable quadratic cost performance measure with structured static state-feedback controllers. We find the optimal control design strategy (in terms of the competitive ratio and domination metrics) when the control designer has access to the local model information and the global interconnection structure of the plant-to-be-controlled. At last, we study the trade-off between the amount of model information exploited by a control design method and the best closed-loop performance (in terms of the competitive ratio) of controllers it can produce.

  18. BWID System Design Study

    Energy Technology Data Exchange (ETDEWEB)

    O' Brien, M.C.; Rudin, M.J.; Morrison, J.L.; Richardson, J.G.

    1991-01-01

    The mission of the Buried Waste Integrated Demonstration (BWID) System Design Study is to identify and evaluate technology process options for the cradle-to-grave remediation of Transuranic (TRU)-Contaminated Waste Pits and Trenches buried at the Idaho National Engineering Laboratory (INEL). Emphasis is placed upon evaluating system configuration options and associated functional and operational requirements for retrieving and treating the buried wastes. A Performance-Based Technology Selection Filter was developed to evaluate the identified remediation systems and their enabling technologies based upon system requirements and quantification of technical Comprehensive Environmental Response, Compensation, and Liability (CERCLA) balancing criteria. Remediation systems will also be evaluated with respect to regulatory and institutional acceptance and cost-effectiveness.

  19. BWID System Design Study

    Energy Technology Data Exchange (ETDEWEB)

    O`Brien, M.C.; Rudin, M.J.; Morrison, J.L.; Richardson, J.G.

    1991-12-31

    The mission of the Buried Waste Integrated Demonstration (BWID) System Design Study is to identify and evaluate technology process options for the cradle-to-grave remediation of Transuranic (TRU)-Contaminated Waste Pits and Trenches buried at the Idaho National Engineering Laboratory (INEL). Emphasis is placed upon evaluating system configuration options and associated functional and operational requirements for retrieving and treating the buried wastes. A Performance-Based Technology Selection Filter was developed to evaluate the identified remediation systems and their enabling technologies based upon system requirements and quantification of technical Comprehensive Environmental Response, Compensation, and Liability (CERCLA) balancing criteria. Remediation systems will also be evaluated with respect to regulatory and institutional acceptance and cost-effectiveness.

  20. Generic Model Host System Design

    Energy Technology Data Exchange (ETDEWEB)

    Chu, Chungming; /SLAC; Wu, Juhao; /SLAC; Qiang, Ji; /LBL, Berkeley; Shen, Guobao; /Brookhaven

    2012-06-22

    There are many simulation codes for accelerator modelling; each one has some strength but not all. A platform which can host multiple modelling tools would be ideal for various purposes. The model platform along with infrastructure support can be used not only for online applications but also for offline purposes. Collaboration is formed for the effort of providing such a platform. In order to achieve such a platform, a set of common physics data structure has to be set. Application Programming Interface (API) for physics applications should also be defined within a model data provider. A preliminary platform design and prototype is discussed.

  1. A Model for Teaching Information Design

    Science.gov (United States)

    Pettersson, Rune

    2011-01-01

    The author presents his views on the teaching of information design. The starting point includes some general aspects of teaching and learning. The multidisciplinary structure and content of information design as well as the combined practical and theoretical components influence studies of the discipline. Experiences from working with a model for…

  2. A Model for Teaching Information Design

    Science.gov (United States)

    Pettersson, Rune

    2011-01-01

    The author presents his views on the teaching of information design. The starting point includes some general aspects of teaching and learning. The multidisciplinary structure and content of information design as well as the combined practical and theoretical components influence studies of the discipline. Experiences from working with a model for…

  3. Network Design Models for Container Shipping

    DEFF Research Database (Denmark)

    Reinhardt, Line Blander; Kallehauge, Brian; Nielsen, Anders Nørrelund

    This paper presents a study of the network design problem in container shipping. The paper combines the network design and fleet assignment problem into a mixed integer linear programming model minimizing the overall cost. The major contributions of this paper is that the time of a vessel route...

  4. Thermionic Reactor Design Studies

    Energy Technology Data Exchange (ETDEWEB)

    Schock, Alfred

    1994-06-01

    During the 1960's and early 70's the author performed extensive design studies, analyses, and tests aimed at thermionic reactor concepts that differed significantly from those pursued by other investigators. Those studies, like most others under Atomic Energy Commission (AEC and DOE) and the National Aeronautics and Space Administration (NASA) sponsorship, were terminated in the early 1970's. Some of this work was previously published, but much of it was never made available in the open literature. U.S. interest in thermionic reactors resumed in the early 80's, and was greatly intensified by reports about Soviet ground and flight tests in the late 80's. This recent interest resulted in renewed U.S. thermionic reactor development programs, primarily under Department of Defense (DOD) and Department of Energy (DOE) sponsorship. Since most current investigators have not had an opportunity to study all of the author's previous work, a review of the highlights of that work may be of value to them. The present paper describes some of the author's conceptual designs and their rationale, and the special analytical techniques developed to analyze their performance. The basic designs, first published in 1963, are based on single-cell converters, either double-ended diodes extending over the full height of the reactor core or single-ended diodes extending over half the core height. In that respect they are similar to the thermionic fuel elements employed in the Topaz-2 reactor subsequently developed in the Soviet Union, copies of which were recently imported by the U.S. As in the Topaz-2 case, electrically heated steady-state performance tests of the converters are possible before fueling. Where the author's concepts differed from the later Topaz-2 design was in the relative location of the emitter and the collector. Placing the fueled emitter on the outside of the cylindrical diodes permits much higher axial conductances to reduce ohmic

  5. Modeling, Simulation and Control Studies on Photovoltaic-Converter System for Mechatronics Design of Solar Electric Application

    Directory of Open Access Journals (Sweden)

    Farhan A. Salem

    2014-12-01

    Full Text Available This paper presents some considerations regarding design, modeling and control solutions for Photovoltaic Panel-Converter (PVPC system. Different control approaches and corresponding models are derived, developed and tested, to control output characteristics and performance of both overall PVPC system and each subsystem to meet desired output characteristics, performance and both and/or either voltages and currents requirements. The proposed approaches and models allow designer have the maximum output numerical visual and graphical data to select, evaluate and control the PVPC system output characteristics for a given PVPC system parameters, under given working conditions of PV panel. The proposed models and approaches were implemented and tested in MATLAB/Simulink

  6. A Model Study of Inclusions Deposition, Macroscopic Transport, and Dynamic Removal at Steel-Slag Interface for Different Tundish Designs

    Science.gov (United States)

    Chen, Chao; Ni, Peiyuan; Jonsson, Lage Tord Ingemar; Tilliander, Anders; Cheng, Guoguang; Jönsson, Pär Göran

    2016-06-01

    This paper presents computational fluid dynamics (CFD) simulation results of inclusions macroscopic transport as well as dynamic removal in tundishes. A novel treatment was implemented using the deposition velocity calculated by a revised unified Eulerian deposition model to replace the widely used Stokes rising velocity in the boundary conditions for inclusions removal at the steel-slag interface in tundishes. In this study, the dynamic removal for different size groups of inclusions at different steel-slag interfaces (smooth or rough) with different absorption conditions at the interface (partially or fully absorbed) in two tundish designs was studied. The results showed that the dynamic removal ratios were higher for larger inclusions than for smaller inclusions. Besides, the dynamic removal ratio was higher for rough interfaces than for smooth interfaces. On the other hand, regarding the cases when inclusions are partially or fully absorbed at a smooth steel-slag interface, the removal ratio values are proportional to the absorption proportion of inclusions at the steel-slag interface. Furthermore, the removal of inclusions in two tundish designs, i.e., with and without a weir and a dam were compared. Specifically, the tundish with a weir and a dam exhibited a better performance with respect to the removal of bigger inclusions (radii of 5, 7, and 9 μm) than that of the case without weir and dam. That was found to be due to the strong paralleling flow near the middle part of the top surface. However, the tundish without weir and dam showed a higher removal ratio of smaller inclusions (radius of 1 μm). The reason could be the presence of a paralleling flow near the inlet zone, where the inclusions deposition velocities were much higher than in other parts.

  7. Multi crop model climate risk country-level management design: case study on the Tanzanian maize production system

    Science.gov (United States)

    Chavez, E.

    2015-12-01

    Future climate projections indicate that a very serious consequence of post-industrial anthropogenic global warming is the likelihood of the greater frequency and intensity of extreme hydrometeorological events such as heat waves, droughts, storms, and floods. The design of national and international policies targeted at building more resilient and environmentally sustainable food systems needs to rely on access to robust and reliable data which is largely absent. In this context, the improvement of the modelling of current and future agricultural production losses using the unifying language of risk is paramount. In this study, we use a methodology that allows the integration of the current understanding of the various interacting systems of climate, agro-environment, crops, and the economy to determine short to long-term risk estimates of crop production loss, in different environmental, climate, and adaptation scenarios. This methodology is applied to Tanzania to assess optimum risk reduction and maize production increase paths in different climate scenarios. The simulations carried out use inputs from three different crop models (DSSAT, APSIM, WRSI) run in different technological scenarios and thus allowing to estimate crop model-driven risk exposure estimation bias. The results obtained also allow distinguishing different region-specific optimum climate risk reduction policies subject to historical as well as RCP2.5 and RCP8.5 climate scenarios. The region-specific risk profiles obtained provide a simple framework to determine cost-effective risk management policies for Tanzania and allow to optimally combine investments in risk reduction and risk transfer.

  8. Mechatronic Systems Design Methods, Models, Concepts

    CERN Document Server

    Janschek, Klaus

    2012-01-01

    In this textbook, fundamental methods for model-based design of mechatronic systems are presented in a systematic, comprehensive form. The method framework presented here comprises domain-neutral methods for modeling and performance analysis: multi-domain modeling (energy/port/signal-based), simulation (ODE/DAE/hybrid systems), robust control methods, stochastic dynamic analysis, and quantitative evaluation of designs using system budgets. The model framework is composed of analytical dynamic models for important physical and technical domains of realization of mechatronic functions, such as multibody dynamics, digital information processing and electromechanical transducers. Building on the modeling concept of a technology-independent generic mechatronic transducer, concrete formulations for electrostatic, piezoelectric, electromagnetic, and electrodynamic transducers are presented. More than 50 fully worked out design examples clearly illustrate these methods and concepts and enable independent study of th...

  9. Designing a Scalable Fault Tolerance Model for High Performance Computational Chemistry: A Case Study with Coupled Cluster Perturbative Triples.

    Science.gov (United States)

    van Dam, Hubertus J J; Vishnu, Abhinav; de Jong, Wibe A

    2011-01-11

    In the past couple of decades, the massive computational power provided by the most modern supercomputers has resulted in simulation of higher-order computational chemistry methods, previously considered intractable. As the system sizes continue to increase, the computational chemistry domain continues to escalate this trend using parallel computing with programming models such as Message Passing Interface (MPI) and Partitioned Global Address Space (PGAS) programming models such as Global Arrays. The ever increasing scale of these supercomputers comes at a cost of reduced Mean Time Between Failures (MTBF), currently on the order of days and projected to be on the order of hours for upcoming extreme scale systems. While traditional disk-based check pointing methods are ubiquitous for storing intermediate solutions, they suffer from high overhead of writing and recovering from checkpoints. In practice, checkpointing itself often brings the system down. Clearly, methods beyond checkpointing are imperative to handling the aggravating issue of reducing MTBF. In this paper, we address this challenge by designing and implementing an efficient fault tolerant version of the Coupled Cluster (CC) method with NWChem, using in-memory data redundancy. We present the challenges associated with our design, including an efficient data storage model, maintenance of at least one consistent data copy, and the recovery process. Our performance evaluation without faults shows that the current design exhibits a small overhead. In the presence of a simulated fault, the proposed design incurs negligible overhead in comparison to the state of the art implementation without faults.

  10. Interior Design Research: A Human Ecosystem Model.

    Science.gov (United States)

    Guerin, Denise A.

    1992-01-01

    The interior ecosystems model illustrates effects on the human organism of the interaction of the natural, behavioral, and built environment. Examples of interior lighting and household energy consumption show the model's flexibility for organizing study variables in interior design research. (SK)

  11. Interior Design Research: A Human Ecosystem Model.

    Science.gov (United States)

    Guerin, Denise A.

    1992-01-01

    The interior ecosystems model illustrates effects on the human organism of the interaction of the natural, behavioral, and built environment. Examples of interior lighting and household energy consumption show the model's flexibility for organizing study variables in interior design research. (SK)

  12. Model of Procedure Usage – Results from a Qualitative Study to Inform Design of Computer-Based Procedures

    Energy Technology Data Exchange (ETDEWEB)

    Johanna H Oxstrand; Katya L Le Blanc

    2012-07-01

    The nuclear industry is constantly trying to find ways to decrease the human error rate, especially the human errors associated with procedure use. As a step toward the goal of improving procedure use performance, researchers, together with the nuclear industry, have been looking at replacing the current paper-based procedures with computer-based procedure systems. The concept of computer-based procedures is not new by any means; however most research has focused on procedures used in the main control room. Procedures reviewed in these efforts are mainly emergency operating procedures and normal operating procedures. Based on lessons learned for these previous efforts we are now exploring a more unknown application for computer based procedures - field procedures, i.e. procedures used by nuclear equipment operators and maintenance technicians. The Idaho National Laboratory, the Institute for Energy Technology, and participants from the U.S. commercial nuclear industry are collaborating in an applied research effort with the objective of developing requirements and specifications for a computer-based procedure system to be used by field operators. The goal is to identify the types of human errors that can be mitigated by using computer-based procedures and how to best design the computer-based procedures to do this. The underlying philosophy in the research effort is “Stop – Start – Continue”, i.e. what features from the use of paper-based procedures should we not incorporate (Stop), what should we keep (Continue), and what new features or work processes should be added (Start). One step in identifying the Stop – Start – Continue was to conduct a baseline study where affordances related to the current usage of paper-based procedures were identified. The purpose of the study was to develop a model of paper based procedure use which will help to identify desirable features for computer based procedure prototypes. Affordances such as note taking, markups

  13. Studies in Interior Design

    Science.gov (United States)

    Environ Planning Design, 1970

    1970-01-01

    Floor plans and photographs illustrate a description of the Samuel C. Williams Library at Stevens Institute of Technology, Hoboken, N.J. The unusual interior design allows students to take full advantage of the library's resources. (JW)

  14. Studies in Interior Design

    Science.gov (United States)

    Environ Planning Design, 1970

    1970-01-01

    Floor plans and photographs illustrate a description of the Samuel C. Williams Library at Stevens Institute of Technology, Hoboken, N.J. The unusual interior design allows students to take full advantage of the library's resources. (JW)

  15. An athymic rat model of cutaneous radiation injury designed to study human tissue-based wound therapy

    Directory of Open Access Journals (Sweden)

    Rifkin Lucas H

    2012-05-01

    Full Text Available Abstract Purpose To describe a pilot study for a novel preclinical model used to test human tissue-based therapies in the setting of cutaneous radiation injury. Methods A protocol was designed to irradiate the skin of athymic rats while sparing the body and internal organs by utilizing a non-occlusive skin clamp along with an x-ray image guided stereotactic irradiator. Each rat was irradiated both on the right and the left flank with a circular field at a 20 cm source-to-surface distance (SSD. Single fractions of 30.4 Gy, 41.5 Gy, 52.6 Gy, 65.5 Gy, and 76.5 Gy were applied in a dose-finding trial. Eight additional wounds were created using the 41.5 Gy dose level. Each wound was photographed and the percentage of the irradiated area ulcerated at given time points was analyzed using ImageJ software. Results No systemic or lethal sequelae occurred in any animals, and all irradiated skin areas in the multi-dose trial underwent ulceration. Greater than 60% of skin within each irradiated zone underwent ulceration within ten days, with peak ulceration ranging from 62.1% to 79.8%. Peak ulceration showed a weak correlation with radiation dose (r = 0.664. Mean ulceration rate over the study period is more closely correlated to dose (r = 0.753. With the highest dose excluded due to contraction-related distortions, correlation between dose and average ulceration showed a stronger relationship (r = 0.895. Eight additional wounds created using 41.5 Gy all reached peak ulceration above 50%, with all healing significantly but incompletely by the 65-day endpoint. Conclusions We developed a functional preclinical model which is currently used to evaluate human tissue-based therapies in the setting of cutaneous radiation injury. Similar models may be widely applicable and useful the development of novel therapies which may improve radiotherapy management over a broad clinical spectrum.

  16. Molecular modelling and drug design.

    Science.gov (United States)

    Meyer, E F; Swanson, S M; Williams, J A

    2000-03-01

    Drug design is a creative act of the same magnitude as composing, sculpting, or writing. The results can touch the lives of millions, but the creator is rarely one scientist and the rewards are distributed differently in the arts than in the sciences. The mechanisms of creativity are the same, i.e., incremental (plodding from darkness to dawn) or sudden (the "Eureka" effect) realization, but both are poorly understood. Creativity remains a human characteristic, but it is directly related to the tools available, especially computer software and hardware. While modelling software continues to mature, very little new has evolved in terms of hardware. Here, we discuss the history of molecular modelling and describe two novel modelling tools, a haptic device and a program, SCULPT, to generate solid molecular models at atomic resolution.

  17. Benefits of Non-Linear Mixed Effect Modeling and Optimal Design : Pre-Clinical and Clinical Study Applications

    OpenAIRE

    Ernest II, Charles Steven

    2013-01-01

    Despite the growing promise of pharmaceutical research, inferior experimentation or interpretation of data can inhibit breakthrough molecules from finding their way out of research institutions and reaching patients. This thesis provides evidence that better characterization of pre-clinical and clinical data can be accomplished using non-linear mixed effect modeling (NLMEM) and more effective experiments can be conducted using optimal design (OD).  To demonstrate applicability of NLMEM and OD...

  18. Random-effects linear modeling and sample size tables for two special crossover designs of average bioequivalence studies: the four-period, two-sequence, two-formulation and six-period, three-sequence, three-formulation designs.

    Science.gov (United States)

    Diaz, Francisco J; Berg, Michel J; Krebill, Ron; Welty, Timothy; Gidal, Barry E; Alloway, Rita; Privitera, Michael

    2013-12-01

    Due to concern and debate in the epilepsy medical community and to the current interest of the US Food and Drug Administration (FDA) in revising approaches to the approval of generic drugs, the FDA is currently supporting ongoing bioequivalence studies of antiepileptic drugs, the EQUIGEN studies. During the design of these crossover studies, the researchers could not find commercial or non-commercial statistical software that quickly allowed computation of sample sizes for their designs, particularly software implementing the FDA requirement of using random-effects linear models for the analyses of bioequivalence studies. This article presents tables for sample-size evaluations of average bioequivalence studies based on the two crossover designs used in the EQUIGEN studies: the four-period, two-sequence, two-formulation design, and the six-period, three-sequence, three-formulation design. Sample-size computations assume that random-effects linear models are used in bioequivalence analyses with crossover designs. Random-effects linear models have been traditionally viewed by many pharmacologists and clinical researchers as just mathematical devices to analyze repeated-measures data. In contrast, a modern view of these models attributes an important mathematical role in theoretical formulations in personalized medicine to them, because these models not only have parameters that represent average patients, but also have parameters that represent individual patients. Moreover, the notation and language of random-effects linear models have evolved over the years. Thus, another goal of this article is to provide a presentation of the statistical modeling of data from bioequivalence studies that highlights the modern view of these models, with special emphasis on power analyses and sample-size computations.

  19. Architecture as Design Study.

    Science.gov (United States)

    Kauppinen, Heta

    1989-01-01

    Explores the use of analogies in architectural design, the importance of Gestalt theory and aesthetic cannons in understanding and being sensitive to architecture. Emphasizes the variation between public and professional appreciation of architecture. Notes that an understanding of architectural process enables students to improve the aesthetic…

  20. Network Design Models for Container Shipping

    DEFF Research Database (Denmark)

    Reinhardt, Line Blander; Kallehauge, Brian; Nielsen, Anders Nørrelund

    This paper presents a study of the network design problem in container shipping. The paper combines the network design and fleet assignment problem into a mixed integer linear programming model minimizing the overall cost. The major contributions of this paper is that the time of a vessel route...... is included in the calculation of the capacity and that a inhomogeneous fleet is modeled. The model also includes the cost of transshipment which is one of the major cost for the shipping companies. The concept of pseudo simple routes is introduced to expand the set of feasible routes. The linearization...

  1. Thermionic Reactor Design Studies

    Energy Technology Data Exchange (ETDEWEB)

    Schock, Alfred

    1994-08-01

    Paper presented at the 29th IECEC in Monterey, CA in August 1994. The present paper describes some of the author's conceptual designs and their rationale, and the special analytical techniques developed to analyze their (thermionic reactor) performance. The basic designs, first published in 1963, are based on single-cell converters, either double-ended diodes extending over the full height of the reactor core or single-ended diodes extending over half the core height. In that respect they are similar to the thermionic fuel elements employed in the Topaz-2 reactor subsequently developed in the Soviet Union, copies of which were recently imported by the U.S. As in the Topaz-2 case, electrically heated steady-state performance tests of the converters are possible before fueling.

  2. Study on Professional Process of Bra Design

    Institute of Scientific and Technical Information of China (English)

    李明菊; 徐朝晖

    2001-01-01

    The process of bra design in the underwear industry is studied. Several important aspects of the process were identified: sizing, fabric selection, pattern development and grading, the use of CAD system, fitting and wear trials. Although the design process relies heavily on the expertise and experience of designers, the modern technology such as CAD can facilitate and optimize the design process, and the fitting process on life models is essential for the underwear design. The differences between domestic underwear companies and foreign major ones mainly lie at the lack of dress form specially used for underwear design, lack of CAD/CAM or not making full use of them, and most of all, lack of the professional bra designers or even skillful pattern designers. The prospects and future model of bra design process were also elaborated in this paper.

  3. Motivation, Instructional Design, Flow, and Academic Achievement at a Korean Online University: A Structural Equation Modeling Study

    Science.gov (United States)

    Joo, Young Ju; Oh, Eunjung; Kim, Su Mi

    2015-01-01

    The purpose of this study is to examine the structural relationships among self-efficacy, intrinsic value, test anxiety, instructional design, flow, and achievement among students at a Korean online university. To address research questions, the researchers administered online surveys to 963 college students at an online university in Korea…

  4. The Internationalisation Cube. A Tentative Model for the Study of Organisational Designs and the Results of Internationalisation in Higher Education.

    Science.gov (United States)

    van Dijk, Hans; Meijer, Kees

    1997-01-01

    Based on results of a Dutch study concerning internationalization of higher education, a model for analyzing the internal institutional process of decision making for, organization of, and implementation of international activities is described. The model positions institutions according to three dimensions: policy (importance attached to…

  5. A compact charge-based model to study the nanoscale undoped double gate MOSFETs for nanoelectronic circuit design using genetic algorithms

    Science.gov (United States)

    Bendib, T.; Djeffal, F.; Arar, D.

    2013-04-01

    The analytical modeling of nanoscale devices is an important area of computer-aided design for fast and accurate nanoelectronic design and optimization. In the present paper, a new approach for modeling semiconductor devices, nanoscale double gate DG MOSFETs, by use of the gradual channel approximation (GC) approach and genetic algorithm optimization technique (GA) is presented. The proposed approach combines the universal optimization and fitting capability of GA and the cost-effective optimization concept of quantum correction, to achieve reliable, accurate and simple compact models for nanoelectronic circuit simulations. Our compact models give good predictions of the quantum capacitance, threshold voltage shift, quantum inversion charge density and drain current. These models have been verified with 2D self-consistent results from numerical calculations of the coupled Poisson-Schrödinger equations. The developed models can also be incorporated into nanoelectronic circuit simulators to study the nanoscale CMOS-based devices without impact on the computational time and data storage.

  6. Design Thinking and Cloud Manufacturing: A Study of Cloud Model Sharing Platform Based on Separated Data Log

    Directory of Open Access Journals (Sweden)

    Zhe Wei

    2013-01-01

    Full Text Available To solve the product data consistency problem which is caused by the portable system that cannot conduct real-time update of product data in mobile environment under the mass customization production mode, a new product data optimistic replication method based on log is presented. This paper focuses on the design thinking provider, probing into a manufacturing resource design thinking cloud platform based on manufacturing resource-locating technologies, and also discuss several application scenarios of cloud locating technologies in the manufacturing environment. The actual demand of manufacturing creates a new mode which is service-oriented and has high efficiency and low consumption. Finally, they are different from the crowd-sourcing application model of Local-Motors. The sharing platform operator is responsible for a master plan for the platform, proposing a open interface standard and establishing a service operation mode.

  7. Molecular modeling of directed self-assembly of block copolymers: Fundamental studies of processing conditions and evolutionary pattern design

    Science.gov (United States)

    Khaira, Gurdaman Singh

    Rapid progress in the semi-conductor industry has pushed for smaller feature sizes on integrated electronic circuits. Current photo-lithographic techniques for nanofabrication have reached their technical limit and are problematic when printing features small enough to meet future industrial requirements. "Bottom-up'' techniques, such as the directed self-assembly (DSA) of block copolymers (BCP), are the primary contenders to compliment current "top-down'' photo-lithography ones. For industrial requirements, the defect density from DSA needs to be less than 1 defect per 10 cm by 10 cm. Knowledge of both material synthesis and the thermodynamics of the self-assembly process are required before optimal operating conditions can be found to produce results adequate for industry. The work present in this thesis is divided into three chapters, each discussing various aspects of DSA as studied via a molecular model that contains the essential physics of BCP self-assembly. Though there are various types of guiding fields that can be used to direct BCPs over large wafer areas with minimum defects, this study focuses only on chemically patterned substrates. The first chapter addresses optimal pattern design by describing a framework where molecular simulations of various complexities are coupled with an advanced optimization technique to find a pattern that directs a target morphology. It demonstrates the first ever study where BCP self-assembly on a patterned substrate is optimized using a three-dimensional description of the block-copolymers. For problems pertaining to DSA, the methodology is shown to converge much faster than the traditional random search approach. The second chapter discusses the metrology of BCP thin films using TEM tomography and X-ray scattering techniques, such as CDSAXS and GISAXS. X-ray scattering has the advantage of being able to quickly probe the average structure of BCP morphologies over large wafer areas; however, deducing the BCP morphology

  8. Considerations for test design to accommodate energy-budget models in ecotoxicology: a case study for acetone in the pond snail Lymnaea stagnalis.

    Science.gov (United States)

    Barsi, Alpar; Jager, Tjalling; Collinet, Marc; Lagadic, Laurent; Ducrot, Virginie

    2014-07-01

    Toxicokinetic-toxicodynamic (TKTD) modeling offers many advantages in the analysis of ecotoxicity test data. Calibration of TKTD models, however, places different demands on test design compared with classical concentration-response approaches. In the present study, useful complementary information is provided regarding test design for TKTD modeling. A case study is presented for the pond snail Lymnaea stagnalis exposed to the narcotic compound acetone, in which the data on all endpoints were analyzed together using a relatively simple TKTD model called DEBkiss. Furthermore, the influence of the data used for calibration on accuracy and precision of model parameters is discussed. The DEBkiss model described toxic effects on survival, growth, and reproduction over time well, within a single integrated analysis. Regarding the parameter estimates (e.g., no-effect concentration), precision rather than accuracy was affected depending on which data set was used for model calibration. In addition, the present study shows that the intrinsic sensitivity of snails to acetone stays the same across different life stages, including the embryonic stage. In fact, the data on egg development allowed for selection of a unique metabolic mode of action for the toxicant. Practical and theoretical considerations for test design to accommodate TKTD modeling are discussed in the hope that this information will aid other researchers to make the best possible use of their test animals. © 2014 SETAC.

  9. Designing verbal autopsy studies

    Directory of Open Access Journals (Sweden)

    Shibuya Kenji

    2010-06-01

    Full Text Available Abstract Background Verbal autopsy analyses are widely used for estimating cause-specific mortality rates (CSMR in the vast majority of the world without high-quality medical death registration. Verbal autopsies -- survey interviews with the caretakers of imminent decedents -- stand in for medical examinations or physical autopsies, which are infeasible or culturally prohibited. Methods and Findings We introduce methods, simulations, and interpretations that can improve the design of automated, data-derived estimates of CSMRs, building on a new approach by King and Lu (2008. Our results generate advice for choosing symptom questions and sample sizes that is easier to satisfy than existing practices. For example, most prior effort has been devoted to searching for symptoms with high sensitivity and specificity, which has rarely if ever succeeded with multiple causes of death. In contrast, our approach makes this search irrelevant because it can produce unbiased estimates even with symptoms that have very low sensitivity and specificity. In addition, the new method is optimized for survey questions caretakers can easily answer rather than questions physicians would ask themselves. We also offer an automated method of weeding out biased symptom questions and advice on how to choose the number of causes of death, symptom questions to ask, and observations to collect, among others. Conclusions With the advice offered here, researchers should be able to design verbal autopsy surveys and conduct analyses with greatly reduced statistical biases and research costs.

  10. Digital Modeling and Shaping of Design Practices

    DEFF Research Database (Denmark)

    Reijonen, Satu

    This paper focuses on the role of digital modeling in shaping coordinative practices between architects and energy engineers in construction design. The paper presents a case study of the use of an energy performance calculation programme, a numeric digital modeling tool, that not only enables......, 2010), and the socio-material constructivist studies of technology (Akrich 1992, Akrich et al. 2000, Latour 1991). The programme influences the coordinative practices in following ways: it shapes the modus of interaction between energy engineers and architects and enforces particular jurisdictional...... of this study suggest that generative potential of digital modeling tools such as the calculation programme resides in their ability to restrictively define the possible roles in, focus of and sequence of working. In addition, digital modeling provides a separate medium with the help of which the design object...

  11. Program design based on a mathematical model using rating of perceived exertion for an elite Japanese sprinter: a case study.

    Science.gov (United States)

    Suzuki, Shozo; Sato, Tasuku; Maeda, Akinobu; Takahashi, Yasuo

    2006-02-01

    We investigated the effects of program design on 400-m sprint time by applying a Rating of Perceived Exertion (RPE) mathematical model to training performance. The subject was 24 years old and had been training for 9 years. His best performance in 400-m sprint competitions was 45.50 seconds. Body weight, resting heart rate, training time and RPE were monitored daily after training sessions. Similarly, performance in 400-m races was recorded 9 times during 2003. At the World Championships in Athletics in France, the subject's team placed eighth in the 1,600-m relay. The RPE mathematical model was able to predict changes in performance. Rate of matching was statistically significant (r(2) = 0.83, F ratio = 34.27, p sprinter indicates a potentially powerful tool that can be applied to accurately assess the effects of training on athletic performance.

  12. Characterization of lipid model membranes designed for studying impact of ceramide species on drug diffusion and penetration.

    Science.gov (United States)

    Ochalek, M; Heissler, S; Wohlrab, J; Neubert, R H H

    2012-05-01

    The stratum corneum (SC) intercellular lipid matrix plays a crucial role in the skin barrier function. In the present study, lipid model membranes mimicking its phase behavior were prepared and characterized using different analytical techniques (i.a. SAXD, HPTLC, ESEM, confocal Raman imaging, ATR-FTIR spectroscopy) in order to obtain well-standardized model membranes for diffusion and penetration studies. The lipid model membranes should be used in the future for studying the impact of each ceramide species on the diffusion and penetration of drugs. The SAXD study confirmed that the lipids within artificial lipid systems are arranged similarly to the lipids in the human SC. The polarization microscopic and ESEM images showed the homogenous deposition of lipids on the polycarbonate filter. Both the HPTLC and confocal Raman imaging studies proved the homogenous distribution of individual lipid classes within the lipid model membranes. First in vitro diffusion experiments (performed using an ATR-FTIR diffusion cell) of the hydrophilic compound, urea, revealed that the lipid model membrane represents even stronger diffusion barrier than the human SC. Copyright © 2012 Elsevier B.V. All rights reserved.

  13. A mathematical model to design a lignocellulosic biofuel supply chain system with a case study based on a region in Central Texas.

    Science.gov (United States)

    An, Heungjo; Wilhelm, Wilbert E; Searcy, Stephen W

    2011-09-01

    This study formulates a model to maximize the profit of a lignocellulosic biofuel supply chain ranging from feedstock suppliers to biofuel customers. The model deals with a time-staged, multi-commodity, production/distribution system, prescribing facility locations and capacities, technologies, and material flows. A case study based on a region in Central Texas demonstrates application of the proposed model to design the most profitable biofuel supply chain under each of several scenarios. A sensitivity analysis identifies that ethanol (ETOH) price is the most significant factor in the economic viability of a lignocellulosic biofuel supply chain. Copyright © 2011 Elsevier Ltd. All rights reserved.

  14. Managing Analysis Models in the Design Process

    Science.gov (United States)

    Briggs, Clark

    2006-01-01

    Design of large, complex space systems depends on significant model-based support for exploration of the design space. Integrated models predict system performance in mission-relevant terms given design descriptions and multiple physics-based numerical models. Both the design activities and the modeling activities warrant explicit process definitions and active process management to protect the project from excessive risk. Software and systems engineering processes have been formalized and similar formal process activities are under development for design engineering and integrated modeling. JPL is establishing a modeling process to define development and application of such system-level models.

  15. Modelling the role of the design context in the design process: a domain-independent approach

    OpenAIRE

    Reymen, Isabelle; Kroes, P.; Basten, T; Durling, D.; Shackleton, J

    2002-01-01

    Domain-independent models of the design process are an important means for facilitating interdisciplinary communication and for supporting multidisciplinary design. Many so-called domain-independent models are, however, not really domain independent. We state that, to be domain independent, the models must abstract from domain-specific aspects, be based on the study of several design disciplines, and be useful for many design disciplines and for multidisciplinary design teams. This paper desc...

  16. "From the Formal to the Innovative": The Use of Case Studies and Sustainable Projects in Developing a Design Process Model for Educating Product/Industrial Designers

    Science.gov (United States)

    Oakes, G. L.; Felton, A. J.; Garner, K. B.

    2006-01-01

    The BSc in computer aided product design (CAPD) course at the University of Wolverhampton was conceived as a collaborative venture in 1989 between the School of Engineering and the School of Art and Design. The award was at the forefront of forging interdisciplinary collaboration at undergraduate level in the field of product design. It has…

  17. "From the Formal to the Innovative": The Use of Case Studies and Sustainable Projects in Developing a Design Process Model for Educating Product/Industrial Designers

    Science.gov (United States)

    Oakes, G. L.; Felton, A. J.; Garner, K. B.

    2006-01-01

    The BSc in computer aided product design (CAPD) course at the University of Wolverhampton was conceived as a collaborative venture in 1989 between the School of Engineering and the School of Art and Design. The award was at the forefront of forging interdisciplinary collaboration at undergraduate level in the field of product design. It has…

  18. Application of a Hierarchical Linear Model to the Study of Adolescent Deviance in an Overlapping Cohort Design.

    Science.gov (United States)

    Raudenbush, Stephen W.; Chan, Wing-Shing

    1993-01-01

    Used data on attitudes toward deviance during adolescence to illustrate assessment of psychometric properties of instrument for studying change, compare adequacy of linear and curvilinear growth models, control for time invariant and time-varying covariates, and link overlapping data cohorts. Findings suggest that prodeviant attitudes increased…

  19. Design, synthesis, antitumor evaluations and molecular modeling studies of novel 3,5-substituted indolin-2-one derivatives

    Institute of Scientific and Technical Information of China (English)

    Hai-hong LI; Jian DING; Hua-liang JIANG; Xiu-hua ZHANG; Jin-zhi TAN; Li-li CHEN; Hong LIU; Xiao-min LUO; Xu SHEN; Li-ping LIN; Kai-xian CHEN

    2007-01-01

    Aim: To design and synthesize a novel class of antitumor agents, featuring the 3,5-substituted indolin-2-one framework. Methods: Based on enzyme binding fea-tures of (Z)-SU5402, introducing a β-pyrrole group at the 3-position of the indolin-2-one core, a series of novel 3,5-substituted indolin-2-ones were designed and synthesized. Four human Carcinoma cell lines of A-431, A-549, MDA-MB-468,and Autosomal Dominant Polycystic Kidney disease were chosen for the cell proliferation assay. Results: Twenty new compounds (la-t) with E configuration have been designed, synthesized and bioassayed. Their structural features were determined by nuclear magnetic resonance (NMR) spectra, low- and high-resolu-tion mass spectra, and confirmed by X-ray crystallography. Although the enzyme assay showed a weak inhibition effect against the epidermal growth factor receptor, vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet-derived growth factor receptor tyrosine kinases, the cell-based antitumor activity was promising. Compounds 1g and 1h showed higher inhibitory activity toward the A-549 and MDA-MB-468 cell lines with IC50 of 0.065-9.4 μmol/L. Conclusion: This study provides a new template for further development of potent antitumor drugs.

  20. Use of models in conceptual design

    NARCIS (Netherlands)

    Bonnema, G. Maarten; Houten, van Fred J.A.M.

    2006-01-01

    This article investigates the use of product models by conceptual designers. After a short introduction, abstraction applied in conceptual design is described. A model that places conceptual design in a three-dimensional space is used. Applications of conceptual design from the literature are used t

  1. Use of models in conceptual design

    NARCIS (Netherlands)

    Bonnema, Gerrit Maarten; van Houten, Frederikus J.A.M.

    2006-01-01

    This article investigates the use of product models by conceptual designers. After a short introduction, abstraction applied in conceptual design is described. A model that places conceptual design in a three-dimensional space is used. Applications of conceptual design from the literature are used t

  2. Designing Experiments for Nonlinear Models - An Introduction

    OpenAIRE

    Johnson, Rachel T.; Montgomery, Douglas C.

    2009-01-01

    The article of record as published may be found at http://dx.doi.org/10.1002/qre.1063 We illustrate the construction of Bayesian D-optimal designs for nonlinear models and compare the relative efficiency of standard designs with these designs for several models and prior distributions on the parameters. Through a relative efficiency analysis, we show that standard designs can perform well in situations where the nonlinear model is intrinsically linear. However, if the model is non...

  3. A Workforce Design Model: Providing Energy to Organizations in Transition

    Science.gov (United States)

    Halm, Barry J.

    2011-01-01

    The purpose of this qualitative study was to examine the change in performance realized by a professional services organization, which resulted in the Life Giving Workforce Design (LGWD) model through a grounded theory research design. This study produced a workforce design model characterized as an organizational blueprint that provides virtuous…

  4. Molecular modeling study for the design of novel acetyl-CoA carboxylase inhibitors using 3D QSAR, molecular docking and dynamic simulations.

    Science.gov (United States)

    Vyas, Vivek K; Dabasia, Mohini; Qureshi, Gulamnizami; Patel, Palak; Ghate, Manjunath

    2017-07-01

    Acetyl-CoA carboxylase (ACC) enzyme plays an important role in the regulation of biosynthesis and oxidation of fatty acids. ACC is a recognized drug target for the treatment of obesity and diabetes. Combination of ligand and structure-based in silico methods along with activity and toxicity prediction provides best lead compounds in the drug discovery process. In this study, a data-set of 100 ACC inhibitors were used for the development of comparative molecular field analysis (CoMFA) and comparative molecular similarity index matrix analysis (CoMSIA) models. The generated contour maps were used for the design of novel ACC inhibitors. CoMFA and CoMSIA models were used for the predication of activity of designed compounds. In silico toxicity risk prediction study was carried out for the designed compounds. Molecular docking and dynamic simulations studies were performed to know the binding mode of designed compounds with the ACC enzyme. The designed compounds showed interactions with key amino acid residues important for catalysis, and good correlation was observed between binding free energy and inhibition of ACC.

  5. Interactive design computation: a case study on quantum design paradigm

    NARCIS (Netherlands)

    Feng, H.

    2013-01-01

    The ever-increasing complexity of design processes fosters novel design computation models to be employed in architectural research and design in order to facilitate accurate data processing and refined decision making. These computation models have enabled designers to work with complex geometry an

  6. Development of design and simulation model and safety study of large-scale hydrogen production using nuclear power.

    Energy Technology Data Exchange (ETDEWEB)

    Gelbard, Fred; Oh, Seungmin (Purdue University, West Lafayette, IN); Rodriguez, Salvador B.; Revankar, Shripad T. (Purdue University, West Lafayette, IN); Gauntt, Randall O.; Cole, Randall K., Jr.; Espinosa, Flor (University of New Mexico, Albuquerque, NM); Drennen, Thomas E.; Tournier, Jean-Michel (University of New Mexico, Albuquerque, NM); Hogan, Kevin (Texas A& M University, College Station, TX); Archuleta, Louis (OMICRON Safety and Risk, Inc., Albuquerque, NM); Malczynski, Leonard A.; Vierow, Karen (Texas A& M University, College Station, TX); McFadden, Katherine Letizia; Martin, William Joseph; El-Genk, Mohamed S. (University of New Mexico, Albuquerque, NM); Louie, David L. Y. (OMICRON Safety and Risk, Inc., Albuquerque, NM)

    2007-10-01

    Before this LDRD research, no single tool could simulate a very high temperature reactor (VHTR) that is coupled to a secondary system and the sulfur iodine (SI) thermochemistry. Furthermore, the SI chemistry could only be modeled in steady state, typically via flow sheets. Additionally, the MELCOR nuclear reactor analysis code was suitable only for the modeling of light water reactors, not gas-cooled reactors. We extended MELCOR in order to address the above deficiencies. In particular, we developed three VHTR input models, added generalized, modular secondary system components, developed reactor point kinetics, included transient thermochemistry for the most important cycles [SI and the Westinghouse hybrid sulfur], and developed an interactive graphical user interface for full plant visualization. The new tool is called MELCOR-H2, and it allows users to maximize hydrogen and electrical production, as well as enhance overall plant safety. We conducted validation and verification studies on the key models, and showed that the MELCOR-H2 results typically compared to within less than 5% from experimental data, code-to-code comparisons, and/or analytical solutions.

  7. Designing a Model for Measuring Manpower Productivity in the Project-based Service Organizations (Electricity Company as Case Study

    Directory of Open Access Journals (Sweden)

    Sayyed Mohammad Reza Davoodi

    2013-02-01

    Full Text Available Manpower productivity index is one of the most important productivity measures. This index is the ratio of added-value to number of the employees (or the employee’s salaries. Regarding this fact that manpower cost, annual depreciation, and annual profit is almost fixed and isn’t indicative of the organizations actual performance, therefore measuring added-value in the common methods is fixed and unrealistic and is not function of the organizational performance. Therefore, with respect to the project-based nature of such organizations, a large amount of their budget is spent for the projects in progress and hence measuring the added-value through the common formula and without considering projects means that large amount of the organizations capital and manpower, which are involved in the project implementation, are not considered in measuring added-value. Therefore, in order to measure the actual performance of the organization, the added-value that is gained from the projects future exploitation should be added to its added-value.In the designed model, added-value is calculated so that all of the organizations outputs include current activities and also the investments that will be exploited in the future. As a result, the calculated value is overall reflects of the organizations performance and also manpower productivity is calculated actually.

  8. The ABC model of prostate cancer: A conceptual framework for the design and interpretation of prognostic studies.

    Science.gov (United States)

    Pettersson, Andreas; Gerke, Travis; Fall, Katja; Pawitan, Yudi; Holmberg, Lars; Giovannucci, Edward L; Kantoff, Philip W; Adami, Hans-Olov; Rider, Jennifer R; Mucci, Lorelei A

    2017-02-02

    There has been limited success in identifying prognostic biomarkers in prostate cancer. A partial explanation may be that insufficient emphasis has been put on clearly defining what type of marker or patient category a biomarker study aims to identify and how different cohort characteristics affect the ability to identify such a marker. In this article, the authors put forth the ABC model of prostate cancer, which defines 3 groups of patients with localized disease that an investigator may seek to identify: patients who, within a given time frame, will not develop metastases even if untreated (category A), will not develop metastases because of radical treatment (category B), or will develop metastases despite radical treatment (category C). The authors demonstrate that follow-up time and prostate-specific antigen screening intensity influence the prevalence of patients in categories A, B, and C in a study cohort, and that prognostic markers must be tested in both treated and untreated cohorts to accurately distinguish the 3 groups. The authors suggest that more emphasis should be put on considering these factors when planning, conducting, and interpreting the results from prostate cancer biomarker studies, and propose the ABC model as a framework to aid in that process. Cancer 2016. © 2017 American Cancer Society.

  9. New physical model design for Vapex experiments

    Energy Technology Data Exchange (ETDEWEB)

    Yazdani, A.; Maini, B.B. [Calgary Univ., AB (Canada)

    2004-07-01

    Solvent extraction is gaining much attention as an in-situ recovery method for difficult to produce heavy oil and tar sand deposits. Vapour extraction (VAPEX) is similar to the steam assisted gravity drainage (SAGD) process used in heavy oil production. In VAPEX, vaporized solvents are used instead of high temperature steam and the viscosity of the oil is reduced in situ. VAPEX is well suited for formations that are thin and where heat losses are unavoidable. It can be applied in the presence of overlying gas caps; bottom water aquifers; low thermal conductivity; high water saturation; clay swelling; and, formation damage. Modelling studies that use rectangular shaped models are limited at high reservoir pressures. This study presents a new design of physical models that overcomes this limitation. The annular space between two cylindrical pipes is used for developing slice-type and sand-filled models. This newly developed model is more compatible with high pressure. This paper compares results of VAPEX experiments using the cylindrical models and the rectangular models. The stabilized drainage rates from the newly developed cylindrical models are in very good agreement with those from the rectangular models. 16 refs., 3 tabs., 11 figs.

  10. Modeling of the Secondary System's Generated Interference and Studying of its Impact on the Secondary System Design

    Directory of Open Access Journals (Sweden)

    R. Jantti

    2010-12-01

    Full Text Available In this paper we study how much capacity a cellular secondary system can achieve if the interference to the TV system is kept under control. The interference is modeled and controlled in a slow fading environment. The secondary system's capacity is computed for the adjacent and for the co-channel (with respect to the TV channel. We study the behavior of the system capacity while changing the size of the no transmission area surrounding the TV coverage area. It turns out that for most of the secondary cell sizes the network with adjacent channel is in interference limited mode and the network with co-channel is in noise limited mode. Since in the co-channel we can not use very high power it is recommended to use in bigger cells only adjacent channel.

  11. Radiant recuperator modelling and design

    Directory of Open Access Journals (Sweden)

    Knežević Suzana D.

    2017-01-01

    Full Text Available Recuperators are frequently used in glass production and metallurgical processes to preheat combustion air by heat exchange with high temperature flue gases. Mass and energy balances of a 15 m high, concurrent radiant recuperator used in a glass fiber production process are given. The balances are used: for validation of a cell modeling method that predicts the performance of different recuperator designs, and for finding a simple solution to improve the existing recuperator. Three possible solutions are analyzed: to use the existing recuperator as a countercurrent one, to add an extra cylinder over the existing construction, and to make a system that consists of a central pipe and two concentric annular ducts. In the latter, two air streams flow in opposite directions, whereas air in the inner annular passage flows concurrently or countercurrently to flue gases. Compared with the concurrent recuperator, the countercurrent has only one drawback: the interface temperature is higher at the bottom. The advantages are: lower interface temperature at the top where the material is under maximal load, higher efficiency, and smaller pressure drop. Both concurrent and countercurrent double pipe-in-pipe systems are only slightly more efficient than pure concurrent and countercurrent recuperators, respectively. Their advantages are smaller interface temperatures whereas the disadvantages are their costs and pressure drops. To implement these solutions, the average velocities should be: for flue gas around 5 m/s, for air in the first passage less than 2 m/s, and for air in the second passage more than 25 m/s. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. EE 33027

  12. A Study on Design-Oriented Demands of VR via ZMET-QFD Model for Industrial Design Education and Students' Learning

    Science.gov (United States)

    Liang, Yo-Wen; Lee, An-Sheng; Liu, Shuo-Fang

    2016-01-01

    The difficulty of Virtual Reality application in industrial design education and learning is VR engineers cannot comprehend what the important functions or elements are for students. In addition, a general-purpose VR usually confuses the students and provides neither good manipulation means nor useful toolkits. To solve these problems, the…

  13. A Study on Design-Oriented Demands of VR via ZMET-QFD Model for Industrial Design Education and Students' Learning

    Science.gov (United States)

    Liang, Yo-Wen; Lee, An-Sheng; Liu, Shuo-Fang

    2016-01-01

    The difficulty of Virtual Reality application in industrial design education and learning is VR engineers cannot comprehend what the important functions or elements are for students. In addition, a general-purpose VR usually confuses the students and provides neither good manipulation means nor useful toolkits. To solve these problems, the…

  14. A Concept Transformation Learning Model for Architectural Design Learning Process

    Science.gov (United States)

    Wu, Yun-Wu; Weng, Kuo-Hua; Young, Li-Ming

    2016-01-01

    Generally, in the foundation course of architectural design, much emphasis is placed on teaching of the basic design skills without focusing on teaching students to apply the basic design concepts in their architectural designs or promoting students' own creativity. Therefore, this study aims to propose a concept transformation learning model to…

  15. A Concept Transformation Learning Model for Architectural Design Learning Process

    Science.gov (United States)

    Wu, Yun-Wu; Weng, Kuo-Hua; Young, Li-Ming

    2016-01-01

    Generally, in the foundation course of architectural design, much emphasis is placed on teaching of the basic design skills without focusing on teaching students to apply the basic design concepts in their architectural designs or promoting students' own creativity. Therefore, this study aims to propose a concept transformation learning model to…

  16. Applicability of heat and gas trans-port models in biocover design based on a case study from Denmark

    DEFF Research Database (Denmark)

    Nielsen, A. A. F.; Binning, Philip John; Kjeldsen, Peter

    2015-01-01

    . Both models used the heat equation for heat transfer, and the numerical model used advection-diffusion model with dual Monod kinetics for gas transport. The results were validated with data from a Danish landfi The models correlated well with the observed data: the coefficient of determination (R2...

  17. Effective use of modeling and simulation in designing bioequivalence and comparability studies of large-molecule compounds: the case of erythropoietin.

    Science.gov (United States)

    Nakai, Kiyohiko; Miyata, Kumiko; Iida, Satofumi; Kawanishi, Takehiko

    2015-06-01

    Bioequivalence and comparability studies are necessary for changing formulations of large-molecule drugs, such as antibody drugs and protein products, and in the development of their biosimilars. This study is the first application of modeling and simulation (M&S) in the design of bioequivalence and comparability studies of erythropoietin as an example of a large-molecule drug. A novel population pharmacokinetic and pharmacodynamic (PPK/PD) model was developed for erythropoietin. Based on this PPK/PD model, the probabilities of success of bioequivalence and comparability studies were simulated with various numbers of subjects and samples. The simulation indicated that the minimum numbers of subjects and samples required to satisfy the criteria for bioequivalence and comparability studies were as follows: fewest for the area under the serum concentration-time curve, more for the area under the efficacy-time curve, and most for the maximum serum concentration of erythropoietin. These results suggested that M&S could be successfully applied in the design of bioequivalence and comparability studies of large-molecule drugs.

  18. Jovian Plasma Modeling for Mission Design

    Science.gov (United States)

    Garrett, Henry B.; Kim, Wousik; Belland, Brent; Evans, Robin

    2015-01-01

    The purpose of this report is to address uncertainties in the plasma models at Jupiter responsible for surface charging and to update the jovian plasma models using the most recent data available. The updated plasma environment models were then used to evaluate two proposed Europa mission designs for spacecraft charging effects using the Nascap-2k code. The original Divine/Garrett jovian plasma model (or "DG1", T. N. Divine and H. B. Garrett, "Charged particle distributions in Jupiter's magnetosphere," J. Geophys. Res., vol. 88, pp. 6889-6903,1983) has not been updated in 30 years, and there are known errors in the model. As an example, the cold ion plasma temperatures between approx.5 and 10 Jupiter radii (Rj) were found by the experimenters who originally published the data to have been underestimated by approx.2 shortly after publication of the original DG1 model. As knowledge of the plasma environment is critical to any evaluation of the surface charging at Jupiter, the original DG1 model needed to be updated to correct for this and other changes in our interpretation of the data so that charging levels could beproperly estimated using the Nascap-2k charging code. As an additional task, the Nascap-2k spacecraft charging tool has been adapted to incorporate the so-called Kappa plasma distribution function--an important component of the plasma model necessary to compute the particle fluxes between approx.5 keV and 100 keV (at the outset of this study,Nascap-2k did not directly incorporate this common representation of the plasma thus limiting the accuracy of our charging estimates). The updating of the DG1 model and its integration into the Nascap-2k design tool means that charging concerns can now be more efficiently evaluated and mitigated. (We note that, given the subsequent decision by the Europa project to utilize solar arrays for its baseline design, surface charging effects have becomeeven more of an issue for its mission design). The modifications and

  19. A compact charge-based model to study the nanoscale undoped double gate MOSFETs for nanoelectronic circuit design using genetic algorithms

    Institute of Scientific and Technical Information of China (English)

    T.Bendib; F.Djeffal; D.Arar

    2013-01-01

    The analytical modeling of nanoscale devices is an important area of computer-aided design for fast and accurate nanoelectronic design and optimization.In the present paper,a new approach for modeling semiconductor devices,nanoscale double gate DG MOSFETs,by use of the gradual channel approximation (GC) approach and genetic algorithm optimization technique (GA) is presented.The proposed approach combines the universal optimization and fitting capability of GA and the cost-effective optimization concept of quantum correction,to achieve reliable,accurate and simple compact models for nanoelectronic circuit simulations.Our compact models give good predictions of the quantum capacitance,threshold voltage shift,quantum inversion charge density and drain current.These models have been verified with 2D self-consistent results from numerical calculations of the coupled Poisson-Schr(o)dinger equations.The developed models can also be incorporated into nanoelectronic circuit simulators to study the nanoscale CMOS-based devices without impact on the computational time and data storage.

  20. Visual Design Principles: An Empirical Study of Design Lore

    Science.gov (United States)

    Kimball, Miles A.

    2013-01-01

    Many books, designers, and design educators talk about visual design principles such as balance, contrast, and alignment, but with little consistency. This study uses empirical methods to explore the lore surrounding design principles. The study took the form of two stages: a quantitative literature review to determine what design principles are…

  1. Visual Design Principles: An Empirical Study of Design Lore

    Science.gov (United States)

    Kimball, Miles A.

    2013-01-01

    Many books, designers, and design educators talk about visual design principles such as balance, contrast, and alignment, but with little consistency. This study uses empirical methods to explore the lore surrounding design principles. The study took the form of two stages: a quantitative literature review to determine what design principles are…

  2. Telecommunications network modelling, planning and design

    CERN Document Server

    Evans, Sharon

    2003-01-01

    Telecommunication Network Modelling, Planning and Design addresses sophisticated modelling techniques from the perspective of the communications industry and covers some of the major issues facing telecommunications network engineers and managers today. Topics covered include network planning for transmission systems, modelling of SDH transport network structures and telecommunications network design and performance modelling, as well as network costs and ROI modelling and QoS in 3G networks.

  3. Designing and Explaining the Model of Persistent Customer Loyalty in e-Commerce: A Study in the e-Retailer’s Web Sites

    Directory of Open Access Journals (Sweden)

    mohammad reza hamidizadeh

    2011-09-01

    While the importance of customer loyalty has been recognized in marketing literature for several decades, the design and explanation of persistent customer loyalty and its antecedents in electronic commerce especially in an e-retailing context have not been addressed. Therefore, the aim of this study is to develop and validate such antecedents of persistent loyalty and to propose a comprehensive model. For this purpose, based on e-commerce and marketing literature, a comprehensive set of constructs have been designed and examined on 211 customers of e-retailers using path analysis. The findings imply that persistent customer loyalty has been influenced significantly by all of the recognized factors including trust, payment security, perceived value, customer satisfaction, customization, purchase convenience, brand character, and contact interactivity. Also, customer satisfaction and trust have mediator role in the model.

  4. The design and testing of a caring teaching model based on the theoretical framework of caring in the Chinese Context: a mixed-method study.

    Science.gov (United States)

    Guo, Yujie; Shen, Jie; Ye, Xuchun; Chen, Huali; Jiang, Anli

    2013-08-01

    This paper aims to report the design and test the effectiveness of an innovative caring teaching model based on the theoretical framework of caring in the Chinese context. Since the 1970's, caring has been a core value in nursing education. In a previous study, a theoretical framework of caring in the Chinese context is explored employing a grounded theory study, considered beneficial for caring education. A caring teaching model was designed theoretically and a one group pre- and post-test quasi-experimental study was administered to test its effectiveness. From Oct, 2009 to Jul, 2010, a cohort of grade-2 undergraduate nursing students (n=64) in a Chinese medical school was recruited to participate in the study. Data were gathered through quantitative and qualitative methods to evaluate the effectiveness of the caring teaching model. The caring teaching model created an esthetic situation and experiential learning style for teaching caring that was integrated within the curricula. Quantitative data from the quasi-experimental study showed that the post-test scores of each item were higher than those on the pre-test (p<0.01). Thematic analysis of 1220 narratives from students' caring journals and reports of participant class observation revealed two main thematic categories, which reflected, from the students' points of view, the development of student caring character and the impact that the caring teaching model had on this regard. The model could be used as an integrated approach to teach caring in nursing curricula. It would also be beneficial for nursing administrators in cultivating caring nurse practitioners. Copyright © 2012 Elsevier Ltd. All rights reserved.

  5. Modelling, analyses and design of switching converters

    Science.gov (United States)

    Cuk, S. M.; Middlebrook, R. D.

    1978-01-01

    A state-space averaging method for modelling switching dc-to-dc converters for both continuous and discontinuous conduction mode is developed. In each case the starting point is the unified state-space representation, and the end result is a complete linear circuit model, for each conduction mode, which correctly represents all essential features, namely, the input, output, and transfer properties (static dc as well as dynamic ac small-signal). While the method is generally applicable to any switching converter, it is extensively illustrated for the three common power stages (buck, boost, and buck-boost). The results for these converters are then easily tabulated owing to the fixed equivalent circuit topology of their canonical circuit model. The insights that emerge from the general state-space modelling approach lead to the design of new converter topologies through the study of generic properties of the cascade connection of basic buck and boost converters.

  6. Analytical model for Stirling cycle machine design

    Energy Technology Data Exchange (ETDEWEB)

    Formosa, F. [Laboratoire SYMME, Universite de Savoie, BP 80439, 74944 Annecy le Vieux Cedex (France); Despesse, G. [Laboratoire Capteurs Actionneurs et Recuperation d' Energie, CEA-LETI-MINATEC, Grenoble (France)

    2010-10-15

    In order to study further the promising free piston Stirling engine architecture, there is a need of an analytical thermodynamic model which could be used in a dynamical analysis for preliminary design. To aim at more realistic values, the models have to take into account the heat losses and irreversibilities on the engine. An analytical model which encompasses the critical flaws of the regenerator and furthermore the heat exchangers effectivenesses has been developed. This model has been validated using the whole range of the experimental data available from the General Motor GPU-3 Stirling engine prototype. The effects of the technological and operating parameters on Stirling engine performance have been investigated. In addition to the regenerator influence, the effect of the cooler effectiveness is underlined. (author)

  7. Analytical model for Stirling cycle machine design

    CERN Document Server

    Formosa, Fabien; 10.1016/j.enconman.2010.02.010

    2013-01-01

    In order to study further the promising free piston Stirling engine architecture, there is a need of an analytical thermodynamic model which could be used in a dynamical analysis for preliminary design. To aim at more realistic values, the models have to take into account the heat losses and irreversibilities on the engine. An analytical model which encompasses the critical flaws of the regenerator and furthermore the heat exchangers effectivenesses has been developed. This model has been validated using the whole range of the experimental data available from the General Motor GPU-3 Stirling engine prototype. The effects of the technological and operating parameters on Stirling engine performance have been investigated. In addition to the regenerator influence, the effect of the cooler effectiveness is underlined.

  8. Structural Studies of Metalloprotein Design

    Science.gov (United States)

    2007-11-02

    TITLE AND SUBTITLE Structural Studies of Metalloprotein Design 6. AUTHOR(S) David W. Christianson 5. FUNDING NUMBERS N00014-96-1-0288 7...0288 PRINCIPAL INVESTIGATOR: David W. Christiansen INSTITUTION: University of Pennsylvania GRANT TITLE: Structural Studies of Metalloprotein

  9. Advanced Powertrain Design Using Model-Based Design

    OpenAIRE

    2014-01-01

    The use of alternative fuels and advanced powertrain technologies has been increasing over the past few years as vehicle emissions and fuel economy have become prominent in both manufacturer needs and consumer demands. With more hybrids emerging from all automotive manufacturers, the use of computer modeling has quickly taken a lead in the testing of these innovative powertrain designs. Although on-vehicle testing remains an important part of the design process, modeling and simulation is pro...

  10. A Model of Designing: Understanding Engineering Design Activity

    DEFF Research Database (Denmark)

    Ahmed, Saeema; Aurisicchio, Marco

    2007-01-01

    This research describes an understanding of design activity through design questions. From a number of previous studies two types of questions have been identified: 1) reasoning questions; and 2) strategic questions. Strategic questions are part of an experienced designers approach to solving...

  11. BLENDING STUDY FOR SRR SALT DISPOSITION INTEGRATION: TANK 50H SCALE-MODELING AND COMPUTER-MODELING FOR BLENDING PUMP DESIGN, PHASE 2

    Energy Technology Data Exchange (ETDEWEB)

    Leishear, R.; Poirier, M.; Fowley, M.

    2011-05-26

    The Salt Disposition Integration (SDI) portfolio of projects provides the infrastructure within existing Liquid Waste facilities to support the startup and long term operation of the Salt Waste Processing Facility (SWPF). Within SDI, the Blend and Feed Project will equip existing waste tanks in the Tank Farms to serve as Blend Tanks where 300,000-800,000 gallons of salt solution will be blended in 1.3 million gallon tanks and qualified for use as feedstock for SWPF. Blending requires the miscible salt solutions from potentially multiple source tanks per batch to be well mixed without disturbing settled sludge solids that may be present in a Blend Tank. Disturbing solids may be problematic both from a feed quality perspective as well as from a process safety perspective where hydrogen release from the sludge is a potential flammability concern. To develop the necessary technical basis for the design and operation of blending equipment, Savannah River National Laboratory (SRNL) completed scaled blending and transfer pump tests and computational fluid dynamics (CFD) modeling. A 94 inch diameter pilot-scale blending tank, including tank internals such as the blending pump, transfer pump, removable cooling coils, and center column, were used in this research. The test tank represents a 1/10.85 scaled version of an 85 foot diameter, Type IIIA, nuclear waste tank that may be typical of Blend Tanks used in SDI. Specifically, Tank 50 was selected as the tank to be modeled per the SRR, Project Engineering Manager. SRNL blending tests investigated various fixed position, non-rotating, dual nozzle pump designs, including a blending pump model provided by the blend pump vendor, Curtiss Wright (CW). Primary research goals were to assess blending times and to evaluate incipient sludge disturbance for waste tanks. Incipient sludge disturbance was defined by SRR and SRNL as minor blending of settled sludge from the tank bottom into suspension due to blending pump operation, where

  12. Optimal crossover designs for the proportional model

    OpenAIRE

    Zheng, Wei

    2013-01-01

    In crossover design experiments, the proportional model, where the carryover effects are proportional to their direct treatment effects, has draw attentions in recent years. We discover that the universally optimal design under the traditional model is E-optimal design under the proportional model. Moreover, we establish equivalence theorems of Kiefer-Wolfowitz's type for four popular optimality criteria, namely A, D, E and T (trace).

  13. Design Thinking and Cloud Manufacturing: A Study of Cloud Model Sharing Platform Based on Separated Data Log

    OpenAIRE

    Zhe Wei; Yixiong Feng; Xiaoyi Wang; Zuowen Sun; Yong Sun

    2013-01-01

    To solve the product data consistency problem which is caused by the portable system that cannot conduct real-time update of product data in mobile environment under the mass customization production mode, a new product data optimistic replication method based on log is presented. This paper focuses on the design thinking provider, probing into a manufacturing resource design thinking cloud platform based on manufacturing resource-locating technologies, and also discuss several application sc...

  14. Rhetorical Design Studies: The Art of Making Design Choices Explicit

    DEFF Research Database (Denmark)

    Halstrøm, Per L.

    2017-01-01

    Design has the potential to affect the situations we are in, the choices we make and the beliefs we live by. Being such an affective field, one might expect that canonized design thinking models and methods would be much concerned with how designers can discover arguments for their design choices...

  15. Design of Safer Flame Retardant Textiles through Inclusion Complex Formation with Cyclodextrins: A Combined Experimental and Modeling Study

    Science.gov (United States)

    Zhang, Nanshan

    size mismatch between them. A novel analytical chemistry technique - tandem mass spectrometry (ESI-Q-TOF) was used to study the inclusion complexes of TPP and CDs. Successful formation of TPP-beta-/gamma-CD-IC was further proved by ESI mass spec in the positive mode. Experimental results demonstrated that 1:1 inclusion complex ions of the guest FR and the host CDs were detected. Experimentally alpha-CD cannot form an IC with TPP and this was further confirmed by tandem mass spec. Mass spectrometry provides a fast and accurate method to investigate cyclodextrin inclusion complexes and verify the formation of ICs. Computational methods were applied to help understand the energetically favorable geometry of TPP and beta-/gamma-CD in their IC form. Semi-empirical theoretical methods (PM3 and PM6) were used to find the global minima of TPP-CD geometry and density functional theory calculations at a B3LYP/6-31G(d) level were employed for elaborate geometry optimization. Solvent effect was also considered using the polarized continuum model (IEF-PCM). Analysis of the results indicated that after optimization, IC geometries provided by PM6 had stronger interactions and were more energetically favorable than the ones calculated by PM3. DFT calculations are more accurate than PM3/PM6 and enabled more interactions between the host and the guest than two semi-empirical approaches. DFT calculations also proved that initial structures prepared by PM6 were more favorable in H-bonding profiles and key energy parameters. For TPP-beta-CD system in vacuum and water, Model A owned a lower total and complexation energy while a stronger interaction between them was present in Model B. In TPP-gamma-CD system, Model B was preferred than Model A in both vacuum and water. This was potentially attributed to more H-bonds formed between TPP and gamma-CD in Model B and its ability to retain most of the internal linkages among primary hydroxyl groups.

  16. Low-level laser therapy: An experimental design for wound management: A case-controlled study in rabbit model

    Directory of Open Access Journals (Sweden)

    Hossein Hodjati

    2014-01-01

    Full Text Available Background: There is a wide array of articles in medical literature for and against the laser effect on wound healing but without discrete effect determination or conclusion. This experimental study aims to evaluate the efficacy of low-level laser therapy on wound healing. Materials and Methods: Thirty-four rabbits were randomly enrolled in two groups after creating a full thickness of 3 × 3 cm wound. The intervention group received low density laser exposure (4 J/cm 2 on days 0, 3 and 6 with diode helium-neon low-intensity laser device (wl = 808 nm and in control group moist wound dressing applied. Finally, wound-healing process was evaluated by both gross and pathological assessment. Results: Fibrin formation was the same in the two groups (P = 0.4 but epithelialisation was much more in laser group (P = 0.02. Wound inflammation of the laser group was smaller than that of the control groups but statistical significance was not shown (P = 0.09. Although more smooth muscle actin was found in the wounds of the laser group but it was not statistically significant (P = 0.3. Wound diameter showed significant decrease in wound area in laser group (P = 0.003. Conclusion: According to our study, it seems that low-level laser therapy accelerates wound healing at least in some phases of healing process. So, we can conclude that our study also shows some hopes for low level laser therapy effect on wound healing at least in animal model.

  17. Educational software design: applying models of learning

    Directory of Open Access Journals (Sweden)

    Stephen Richards

    1996-12-01

    Full Text Available The model of learning adopted within this paper is the 'spreading ripples' (SR model proposed by Race (1994. This model was chosen for two important reasons. First, it makes use of accessible ideas and language, .and is therefore simple. Second, .Race suggests that the model can be used in the design, of educational and training programmes (and can thereby be applied to the design of computer-based learning materials.

  18. Use of two-part regression calibration model to correct for measurement error in episodically consumed foods in a single-replicate study design: EPIC case study.

    Directory of Open Access Journals (Sweden)

    George O Agogo

    Full Text Available In epidemiologic studies, measurement error in dietary variables often attenuates association between dietary intake and disease occurrence. To adjust for the attenuation caused by error in dietary intake, regression calibration is commonly used. To apply regression calibration, unbiased reference measurements are required. Short-term reference measurements for foods that are not consumed daily contain excess zeroes that pose challenges in the calibration model. We adapted two-part regression calibration model, initially developed for multiple replicates of reference measurements per individual to a single-replicate setting. We showed how to handle excess zero reference measurements by two-step modeling approach, how to explore heteroscedasticity in the consumed amount with variance-mean graph, how to explore nonlinearity with the generalized additive modeling (GAM and the empirical logit approaches, and how to select covariates in the calibration model. The performance of two-part calibration model was compared with the one-part counterpart. We used vegetable intake and mortality data from European Prospective Investigation on Cancer and Nutrition (EPIC study. In the EPIC, reference measurements were taken with 24-hour recalls. For each of the three vegetable subgroups assessed separately, correcting for error with an appropriately specified two-part calibration model resulted in about three fold increase in the strength of association with all-cause mortality, as measured by the log hazard ratio. Further found is that the standard way of including covariates in the calibration model can lead to over fitting the two-part calibration model. Moreover, the extent of adjusting for error is influenced by the number and forms of covariates in the calibration model. For episodically consumed foods, we advise researchers to pay special attention to response distribution, nonlinearity, and covariate inclusion in specifying the calibration model.

  19. Multimission Aircraft Design Study, Payload

    Science.gov (United States)

    2003-03-01

    iterated several times up to the level time allowed. 1.4 Scope It is necessary to recall that the backgrounds of the Systems Engineering Design Team...landing options are as wheels, skids, parachutes, airbags and none; that is, letting it fly forever or crash. Trade studies should be done in order to

  20. Designing a Mathematical Model for Allocating Budget to University Research and Educational Goals: A Case Study in Shahed University

    Directory of Open Access Journals (Sweden)

    Saeed Safari

    2012-07-01

    Full Text Available Institutions of higher education, both public and private, are among the most important institutions of a country. Several economic factors have forced them to act for improving the cost-effectiveness of their activities and the quality of their products (outputs is strongly expected. Such issues have led universities to focus on profit-making activities and commercialization like manufacturing industries. This propensity is grounded in the fact that manufacturing industries working under an efficient management system can produce very high-quality products. As a matter of fact, there is no such a model for academic contexts. Therefore, this paper is aimed at offering such a model. The coefficients and constants used in this model have all been extracted based on analyzing research and educational aspects of Shahed University. The proposed model is a lexicographic model which has thirty six decision variables that are broken down into two classes of university sources variables (fifteen and university products variables. The model also includes forty nine goals, seven structural constraints and twenty integer variables. At the end of the paper, the current situation is compared with the recommended one and it shows that many of the variables are suboptimal except variables of research and educational officials (S9, graduate (P7 and PhD (P9 night course students number. The comprehensiveness of this model enables managers to plan the smallest research and educational activities and the solutions can be used by managers as applied guidelines.

  1. Designing user models in a virtual cave environment

    Energy Technology Data Exchange (ETDEWEB)

    Brown-VanHoozer, S. [Argonne National Lab., Idaho Falls, ID (United States); Hudson, R. [Argonne National Lab., IL (United States); Gokhale, N. [Madge Networks, San Jose, CA (United States)

    1995-12-31

    In this paper, the results of a first study into the use of virtual reality for human factor studies and design of simple and complex models of control systems, components, and processes are described. The objective was to design a model in a virtual environment that would reflect more characteristics of the user`s mental model of a system and fewer of the designer`s. The technology of a CAVE{trademark} virtual environment and the methodology of Neuro Linguistic Programming were employed in this study.

  2. Design Oriented Structural Modeling for Airplane Conceptual Design Optimization

    Science.gov (United States)

    Livne, Eli

    1999-01-01

    The main goal for research conducted with the support of this grant was to develop design oriented structural optimization methods for the conceptual design of airplanes. Traditionally in conceptual design airframe weight is estimated based on statistical equations developed over years of fitting airplane weight data in data bases of similar existing air- planes. Utilization of such regression equations for the design of new airplanes can be justified only if the new air-planes use structural technology similar to the technology on the airplanes in those weight data bases. If any new structural technology is to be pursued or any new unconventional configurations designed the statistical weight equations cannot be used. In such cases any structural weight estimation must be based on rigorous "physics based" structural analysis and optimization of the airframes under consideration. Work under this grant progressed to explore airframe design-oriented structural optimization techniques along two lines of research: methods based on "fast" design oriented finite element technology and methods based on equivalent plate / equivalent shell models of airframes, in which the vehicle is modelled as an assembly of plate and shell components, each simulating a lifting surface or nacelle / fuselage pieces. Since response to changes in geometry are essential in conceptual design of airplanes, as well as the capability to optimize the shape itself, research supported by this grant sought to develop efficient techniques for parametrization of airplane shape and sensitivity analysis with respect to shape design variables. Towards the end of the grant period a prototype automated structural analysis code designed to work with the NASA Aircraft Synthesis conceptual design code ACS= was delivered to NASA Ames.

  3. TRISO Fuel Performance: Modeling, Integration into Mainstream Design Studies, and Application to a Thorium-fueled Fusion-Fission Hybrid Blanket

    Energy Technology Data Exchange (ETDEWEB)

    Powers, Jeffrey James [Univ. of California, Berkeley, CA (United States)

    2011-11-30

    This study focused on creating a new tristructural isotropic (TRISO) coated particle fuel performance model and demonstrating the integration of this model into an existing system of neutronics and heat transfer codes, creating a user-friendly option for including fuel performance analysis within system design optimization and system-level trade-off studies. The end product enables both a deeper understanding and better overall system performance of nuclear energy systems limited or greatly impacted by TRISO fuel performance. A thorium-fueled hybrid fusion-fission Laser Inertial Fusion Energy (LIFE) blanket design was used for illustrating the application of this new capability and demonstrated both the importance of integrating fuel performance calculations into mainstream design studies and the impact that this new integrated analysis had on system-level design decisions. A new TRISO fuel performance model named TRIUNE was developed and verified and validated during this work with a novel methodology established for simulating the actual lifetime of a TRISO particle during repeated passes through a pebble bed. In addition, integrated self-consistent calculations were performed for neutronics depletion analysis, heat transfer calculations, and then fuel performance modeling for a full parametric study that encompassed over 80 different design options that went through all three phases of analysis. Lastly, side studies were performed that included a comparison of thorium and depleted uranium (DU) LIFE blankets as well as some uncertainty quantification work to help guide future experimental work by assessing what material properties in TRISO fuel performance modeling are most in need of improvement. A recommended thorium-fueled hybrid LIFE engine design was identified with an initial fuel load of 20MT of thorium, 15% TRISO packing within the graphite fuel pebbles, and a 20cm neutron multiplier layer with beryllium pebbles in flibe molten salt coolant. It operated

  4. Pressure prediction model for compression garment design.

    Science.gov (United States)

    Leung, W Y; Yuen, D W; Ng, Sun Pui; Shi, S Q

    2010-01-01

    Based on the application of Laplace's law to compression garments, an equation for predicting garment pressure, incorporating the body circumference, the cross-sectional area of fabric, applied strain (as a function of reduction factor), and its corresponding Young's modulus, is developed. Design procedures are presented to predict garment pressure using the aforementioned parameters for clinical applications. Compression garments have been widely used in treating burning scars. Fabricating a compression garment with a required pressure is important in the healing process. A systematic and scientific design method can enable the occupational therapist and compression garments' manufacturer to custom-make a compression garment with a specific pressure. The objectives of this study are 1) to develop a pressure prediction model incorporating different design factors to estimate the pressure exerted by the compression garments before fabrication; and 2) to propose more design procedures in clinical applications. Three kinds of fabrics cut at different bias angles were tested under uniaxial tension, as were samples made in a double-layered structure. Sets of nonlinear force-extension data were obtained for calculating the predicted pressure. Using the value at 0° bias angle as reference, the Young's modulus can vary by as much as 29% for fabric type P11117, 43% for fabric type PN2170, and even 360% for fabric type AP85120 at a reduction factor of 20%. When comparing the predicted pressure calculated from the single-layered and double-layered fabrics, the double-layered construction provides a larger range of target pressure at a particular strain. The anisotropic and nonlinear behaviors of the fabrics have thus been determined. Compression garments can be methodically designed by the proposed analytical pressure prediction model.

  5. A Generic Design Model for Evolutionary Algorithms

    Institute of Scientific and Technical Information of China (English)

    He Feng; Kang Li-shan; Chen Yu-ping

    2003-01-01

    A generic design model for evolutionary algo rithms is proposed in this paper. The model, which was described by UML in details, focuses on the key concepts and mechanisms in evolutionary algorithms. The model not only achieves separation of concerns and encapsulation of implementations by classification and abstraction of those concepts,it also has a flexible architecture due to the application of design patterns. As a result, the model is reusable, extendible,easy to understand, easy to use, and easy to test. A large number of experiments applying the model to solve many different problems adequately illustrate the generality and effectivity of the model.

  6. Product Modelling and Functional Reasoning in Conceptual Design

    Institute of Scientific and Technical Information of China (English)

    林志航; 宋慧军; 陈康宁

    2004-01-01

    In this paper, a product model in conceptual design, Domain Structure Template, is proposed, which combines the functional domain and the physical domain with the behaviour domain. Seven types of primary mappings units connecting functions, behaviours and carriers during conceptual design process are identified according to the characteristics of the conceptual design of mechanical products.Based on these seven primary mappings, a hierarchical functional reasoning framework characterizing the process of conceptual design is presented. A case study for the conceptual design of industry sewing machines with chain-stitch is described to demonstrate the product modelling and the scheme generation based on the presented model.

  7. Robust Designs for Three Commonly Used Nonlinear Models

    Science.gov (United States)

    Xu, Xiaojian; Chen, Arnold

    2011-11-01

    In this paper, we study the robust designs for a few nonlinear models, including an exponential model with an intercept, a compartmental model, and a Michaelis-Menten model, when these models are possibly misspecified. The minimax robust designs we considered in this paper are under consideration of not only minimizing the variances but also reducing the possible biases in estimation. Both prediction and extrapolation cases are discussed. The robust designs are found incorporating the approximation of these models with several situations such as homoscedasticity, and heteroscedasticity. Both ordinary and weighted nonlinear least squares methods are utilized.

  8. NATO Advanced Study Institute on Engineering of Crystalline Materials Properties : State of the Art in Modeling Design and Applications. New Materials for better Defence and Security

    CERN Document Server

    Braga, Dario; Addadi, Lia

    2008-01-01

    This volume collects the lecture notes (ordered alphabetically according to the first author surname) of the talks delivered by the main speakers at the Erice 2007 International School of Crystallography, generously selected by NATO as an Advanced Study Institute (# 982582). The aim of the school was to discuss the state-of-the-art in molecular materials design, that is, the rational analysis and fabrication of crystalline solids showing a predefined structural organization of their component molecules and ions, which results in the manifestation of a specific collective property of technological interest. The School was held on June 7–17, 2007, in Erice (an old town, over 3000 years, located on the top of a Sicilian hill that oversees the sea near Trapani). The school developed following two parallel lines. First we established “where we are” in terms of modelling, design, synthesis and applications of crystalline solids with predefined properties. Second, we attempted to define current and possible fu...

  9. “诗意的盒子空间”模型设计与制作--环境设计专业建筑模型设计课程实践研究%“Poetic Box Space”Model Design and Production--Practical Study on Building Models Designing Course for Environmental Design Major

    Institute of Scientific and Technical Information of China (English)

    杨晓帆

    2015-01-01

    建筑模型设计课程是针对环境设计专业二年级所开设的“,诗意的盒子空间”模型设计与制作分为此课程的实践训练环节。学生通过学习模型技巧、欣赏案例作品、分小组进行课题讨论、主题模型制作、拍摄制作过程、PPT汇报模型成果、学生讨论评比以及最后书写设计制作心得体会等。在课程当中学生能够自发地去研究空间造型、功能、开合方式以及开合秩序等问题,充分发挥主观能动性,培养手脑并用的实践能力和团队协作能力。%Building models designing course is opened for sophomore majoring in environmental design,"Poetic box space"model design and production are the practice training sessions for this course. Students learn the modelling skills,appreciate case works, discuss topics in small groups,make themes modeling,film the production process, PPT report the modelling results,students discuss and compete, and finally write experience of design and produc⁃tion. In the course, students can go to study space modeling,functions,opening and closing ways and orders and oth⁃er issues spontaneously, make full use of their initiative ability and cultivate their practical ability and team spirit.

  10. A Physical Model to Study the Effects of Nozzle Design on Dense Two-Phase Flows in a Slab Mold Casting Ultra-Low Carbon Steels

    Science.gov (United States)

    Salazar-Campoy, María M.; Morales, R. D.; Nájera-Bastida, A.; Cedillo-Hernández, Valentín; Delgado-Pureco, J. C.

    2017-01-01

    Momentum transfer of argon-steel flows in a slab mold were studied through an air-water physical model and particle image velocimetry measurements under the effects of nozzle design (nozzles with square ports S, square ports with bottom design U and circular ports C) and gas flow rate. The ratio of drag momentum of the gas phase over the liquid phase defines the conditions for coupled (existence of momentum transfer between the phases) and channeled flows (defined as those conditions where there is not further momentum transfer between both phases). When the ratio of superficial velocities of the gas phase over the liquid phase in the nozzle bore is less than 0.14, the flow pattern in the mold is dependent on the nozzle design and flow rate of gas (2 to 10 L/minute). Above this magnitude, the flow pattern becomes uncoupled and independent from the nozzle design and from the flow rate of gas. The ratios of drag velocities of the gas phase on the liquid phase and their superficial velocities in the nozzle bore are strongly dependent on the volume fraction of the gas phase. Nozzle U delivers the smallest sizes of bubbles and the smaller amount of bubble swarms per unit time impacting on the narrow face of the mold. It is, therefore, the most recommendable to cast ultra-low carbon steels. Practical implications derived from these results are written down in the text.

  11. Designing healthy communities: Testing the walkability model

    Directory of Open Access Journals (Sweden)

    Adriana A. Zuniga-Teran

    2017-03-01

    Full Text Available Research from multiple domains has provided insights into how neighborhood design can be improved to have a more favorable effect on physical activity, a concept known as walkability. The relevant research findings/hypotheses have been integrated into a Walkability Framework, which organizes the design elements into nine walkability categories. The purpose of this study was to test whether this conceptual framework can be used as a model to measure the interactions between the built environment and physical activity. We explored correlations between the walkability categories and physical activity reported through a survey of residents of Tucson, Arizona (n=486. The results include significant correlations between the walkability categories and physical activity as well as between the walkability categories and the two motivations for walking (recreation and transportation. To our knowledge, this is the first study that reports links between walkability and walking for recreation. Additionally, the use of the Walkability Framework allowed us to identify the walkability categories most strongly correlated with the two motivations for walking. The results of this study support the use of the Walkability Framework as a model to measure the built environment in relation to its ability to promote physical activity.

  12. Consequence Based Design. An approach for integrating computational collaborative models (Integrated Dynamic Models) in the building design phase

    DEFF Research Database (Denmark)

    Negendahl, Kristoffer

    affect the design process and collaboration between building designers and simulationists. Within the limits of applying the approach of Consequence based design to five case studies, followed by documentation based on interviews, surveys and project related documentations derived from internal reports...... that secures validity and quality assurance with a simulationist while sustaining autonomous control of building design with the building designer. Consequence based design is defined by the specific use of integrated dynamic models. These models include the parametric capabilities of a visual programming tool...... relies on various advancements in the area of integrated dynamic models. It also relies on the application and test of the approach in practice to evaluate the Consequence based design and the use of integrated dynamic models. As a result, the Consequence based design approach has been applied in five...

  13. Behavior and Design Intent Based Product Modeling

    Directory of Open Access Journals (Sweden)

    László Horváth

    2004-11-01

    Full Text Available A knowledge based modeling of mechanical products is presented for industrial CAD/CAM systems. An active model is proposed that comprise knowledge from modeling procedures, generic part models and engineers. Present day models of mechanical systems do not contain data about the background of human decisions. This situation motivated the authors at their investigations on exchange design intent information between engineers. Their concept was extending of product models to be capable of description of design intent information. Several human-computer and human-human communication issues were considered. The complex communication problem has been divided into four sub-problems, namely communication of human intent source with the computer system, representation of human intent, exchange of intent data between modeling procedures and communication of the represented intent with humans. Paper discusses the scenario of intelligent modeling based engineering. Then key concepts for the application of computational intelligence in computer model based engineering systems are detailed including knowledge driven models as well as areas of their application. Next, behavior based models with intelligent content involving specifications and knowledge for the design processes are emphasized and an active part modeling is proposed and possibilities for its application are outlined. Finally, design intent supported intelligent modeling is discussed.

  14. Designing Public Library Websites for Teens: A Conceptual Model

    Science.gov (United States)

    Naughton, Robin Amanda

    2012-01-01

    The main goal of this research study was to develop a conceptual model for the design of public library websites for teens (TLWs) that would enable designers and librarians to create library websites that better suit teens' information needs and practices. It bridges a gap in the research literature between user interface design in human-computer…

  15. Designing Public Library Websites for Teens: A Conceptual Model

    Science.gov (United States)

    Naughton, Robin Amanda

    2012-01-01

    The main goal of this research study was to develop a conceptual model for the design of public library websites for teens (TLWs) that would enable designers and librarians to create library websites that better suit teens' information needs and practices. It bridges a gap in the research literature between user interface design in…

  16. Decision models in designing flexible production systems

    Directory of Open Access Journals (Sweden)

    Florescu Adriana

    2017-01-01

    Full Text Available Flexible production system is a complex whole that raise some issues in terms of its design and in relation to the conditions for implementing it. To implement a flexible production system configuration must be found that satisfies both economic and system performance requirements. The configuration which best meet the objectives of introducing a flexible production system must be sought in the set of alternatives defined and evaluated. In this paper we present a methodology of realising the configuration and complex evaluation of the analyzed system. It will be developed models which generate new alternative configurations, optimization and evaluation models of the performance of the flexible production system. This will create a framework for interactive decision support, user-oriented that can be used by management to solve this selection problem. The applicative character of the study consist in tracking of the technological process in real time using the developed software package on the designed system, based on mathematical models for configuration and optimization of the system.

  17. Building performance modelling for sustainable building design

    National Research Council Canada - National Science Library

    Oduyemi, Olufolahan; Okoroh, Michael

    2016-01-01

    ...) called Ecotect for sustainable building design. Finally, it introduces a design tool analysis of a case study using Ecotect to evaluate various what if scenarios on a proposed multi-use building...

  18. A Force Structure Design Model

    Science.gov (United States)

    1991-09-01

    199) WRITE(20,*)’ MODEL FAR10 /ALL/’ WRITE(20, 159) 159 FORMAT(’*------------- LOOP--------------- WRITE(20,*) ’SOLVE FAR10 USING RMIP MINIMIZING...SOLVE FARIO USING RMIP MINIMIZING MAXDEV OPTION X:4:0:1 DISPLAY X.L OPTION FAR:4:O:1; DISPLAY FAR OPTION R:4:0:1 OPTION R1:4:Q:1 OPTION R2:4:0:1...LOOP ------------------------ 102 SOLVE FAR10 USING RMIP MINIMIZING MAXDEV 103 OPTION X:4:0:1 104 DISPLAY X.L 105 OPTION FAR

  19. LIMIT THEOREMS AND OPTIMAL DESIGN WITH ADAPTIVE URN MODELS

    Institute of Scientific and Technical Information of China (English)

    CHEN Guijing; ZHU Chunhua; WANG Yao-hung

    2005-01-01

    In this paper we study urn model, using some available estimates of successes probabilities, and adding particle parameter, we establish adaptive models. We obtain some strong convergence theorems, rates of convergence, asymptotic normality of components in the urn, and estimates. With these asymptotical results, we show that the adaptive designs given in this paper are asymptotically optimal designs.

  20. Conceptual Models Core to Good Design

    CERN Document Server

    Johnson, Jeff

    2011-01-01

    People make use of software applications in their activities, applying them as tools in carrying out tasks. That this use should be good for people--easy, effective, efficient, and enjoyable--is a principal goal of design. In this book, we present the notion of Conceptual Models, and argue that Conceptual Models are core to achieving good design. From years of helping companies create software applications, we have come to believe that building applications without Conceptual Models is just asking for designs that will be confusing and difficult to learn, remember, and use. We show how Concept

  1. Efimov studies of an ultracold cloud of 39 K atoms in microgravity: Numerical modelling and experimental design

    Science.gov (United States)

    Mossman, Maren; Engels, Peter; D'Incao, Jose; Jin, Deborah; Cornell, Eric

    2016-05-01

    Ultracold atomic gases at or near quantum degeneracy provide a powerful tool for the investigation of few-body physics. A particularly intriguing few-body phenomenon is the existence of Efimov trimer states at large interatomic scattering lengths. These trimers are predicted to exhibit universal geometric scaling relations, but in practice the situation is complicated e.g. by finite-range and finite-temperature effects. While some Efimov trimers have already been experimentally observed by several groups in ground-based experiments, NASA's Cold Atom Laboratory (CAL) onboard the ISS will greatly enhance the experimentally accessible regimes by providing ultracold clouds of 39 K atoms with temperatures at or below 1 nK, low densities, and long observation times. We present results of numerical modelling and simulations that lay out Efimov experiments capitalizing on the particular strengths of CAL.

  2. Design Evolution Study - Aging Options

    Energy Technology Data Exchange (ETDEWEB)

    P. McDaniel

    2002-04-05

    The purpose of this study is to identify options and issues for aging commercial spent nuclear fuel received for disposal at the Yucca Mountain Mined Geologic Repository. Some early shipments of commercial spent nuclear fuel to the repository may be received with high-heat-output (younger) fuel assemblies that will need to be managed to meet thermal goals for emplacement. The capability to age as much as 40,000 metric tons of heavy metal of commercial spent nuclear he1 would provide more flexibility in the design to manage this younger fuel and to decouple waste receipt and waste emplacement. The following potential aging location options are evaluated: (1) Surface aging at four locations near the North Portal; (2) Subsurface aging in the permanent emplacement drifts; and (3) Subsurface aging in a new subsurface area. The following aging container options are evaluated: (1) Complete Waste Package; (2) Stainless Steel inner liner of the waste package; (3) Dual Purpose Canisters; (4) Multi-Purpose Canisters; and (5) New disposable canister for uncanistered commercial spent nuclear fuel. Each option is compared to a ''Base Case,'' which is the expected normal waste packaging process without aging. A Value Engineering approach is used to score each option against nine technical criteria and rank the options. Open issues with each of the options and suggested future actions are also presented. Costs for aging containers and aging locations are evaluated separately. Capital costs are developed for direct costs and distributable field costs. To the extent practical, unit costs are presented. Indirect costs, operating costs, and total system life cycle costs will be evaluated outside of this study. Three recommendations for aging commercial spent nuclear fuel--subsurface, surface, and combined surface and subsurface are presented for further review in the overall design re-evaluation effort. Options that were evaluated but not recommended are

  3. [Saarland Growth Study: sampling design].

    Science.gov (United States)

    Danker-Hopfe, H; Zabransky, S

    2000-01-01

    The use of reference data to evaluate the physical development of children and adolescents is part of the daily routine in the paediatric ambulance. The construction of such reference data is based on the collection of extensive reference data. There are different kinds of reference data: cross sectional references, which are based on data collected from a big representative cross-sectional sample of the population, longitudinal references, which are based on follow-up surveys of usually smaller samples of individuals from birth to maturity, and mixed longitudinal references, which are a combination of longitudinal and cross-sectional reference data. The advantages and disadvantages of the different methods of data collection and the resulting reference data are discussed. The Saarland Growth Study was conducted for several reasons: growth processes are subject to secular changes, there are no specific reference data for children and adolescents from this part of the country and the growth charts in use in the paediatric praxis are possibly not appropriate any more. Therefore, the Saarland Growth Study served two purposes a) to create actual regional reference data and b) to create a database for future studies on secular trends in growth processes of children and adolescents from Saarland. The present contribution focusses on general remarks on the sampling design of (cross-sectional) growth surveys and its inferences for the design of the present study.

  4. Micromechatronics modeling, analysis, and design with Matlab

    CERN Document Server

    Giurgiutiu, Victor

    2009-01-01

    Focusing on recent developments in engineering science, enabling hardware, advanced technologies, and software, Micromechatronics: Modeling, Analysis, and Design with MATLAB®, Second Edition provides clear, comprehensive coverage of mechatronic and electromechanical systems. It applies cornerstone fundamentals to the design of electromechanical systems, covers emerging software and hardware, introduces the rigorous theory, examines the design of high-performance systems, and helps develop problem-solving skills. Along with more streamlined material, this edition adds many new sections to exist

  5. Experimental design of a waste glass study

    Energy Technology Data Exchange (ETDEWEB)

    Piepel, G.F.; Redgate, P.E.; Hrma, P.

    1995-04-01

    A Composition Variation Study (CVS) is being performed to support a future high-level waste glass plant at Hanford. A total of 147 glasses, covering a broad region of compositions melting at approximately 1150{degrees}C, were tested in five statistically designed experimental phases. This paper focuses on the goals, strategies, and techniques used in designing the five phases. The overall strategy was to investigate glass compositions on the boundary and interior of an experimental region defined by single- component, multiple-component, and property constraints. Statistical optimal experimental design techniques were used to cover various subregions of the experimental region in each phase. Empirical mixture models for glass properties (as functions of glass composition) from previous phases wee used in designing subsequent CVS phases.

  6. The design of the Dutch EASYcare study: a randomised controlled trial on the effectiveness of a problem-based community intervention model for frail elderly people [NCT00105378

    Directory of Open Access Journals (Sweden)

    van Achterberg Theo

    2005-10-01

    Full Text Available Abstract Background Because of their complex clinical presentations and needs frail elderly people require another approach than people who age without many complications. Several inpatient geriatric health services have proven effectiveness in frail persons. However, the wish to live independently and policies that promote independent living as an answer to population aging call for community intervention models for frail elderly people. Maybe models such as preventive home visits, comprehensive geriatric assessment, and intermediate care qualify, but their efficacy is controversial, especially in frail elderly persons living in the community. With the Dutch EASYcare Study Geriatric Intervention Programme (DGIP we developed a model to study effectiveness of problem based community intervention models in frail elderly people. Methods/Design DGIP is a community intervention model for frail elderly persons where the GP refers elderly patients with a problem in cognition, mood, behaviour, mobility, and nutrition. A geriatric specialist nurse applies a guideline-based intervention with a limited number of follow up visits. The intervention starts with the application of the EASYcare instrument for geriatric screening. The EASYcare instrument assesses (instrumental activities of daily life, cognition, mood, and includes a goal setting item. During the intervention the nurse regularly consults the referring GP and a geriatrician. Effects on functional performance (Groningen Activity Restriction Scale, health related quality of life (MOS-20, and carer burden (Zarit Burden Interview are studied in an observer blinded randomised controlled trial. 151 participants were randomised over two treatment arms – DGIP and regular care – using pseudo cluster randomisation. We are currently performing the follow up visits. These visits are planned three and six months after inclusion. Process measures and cost measures will be recorded. Intention to treat

  7. The influence of design characteristics on statistical inference in nonlinear estimation: A simulation study based on survival data and hazard modeling

    DEFF Research Database (Denmark)

    Andersen, J.S.; Bedaux, J.J.M.; Kooijman, S.A.L.M.;

    2000-01-01

    This paper describes the influence of design characteristics on the statistical inference for an ecotoxicological hazard-based model using simulated survival data. The design characteristics of interest are the number and spacing of observations (counts) in time, the number and spacing of exposure...

  8. Fire Models and Design Fires

    DEFF Research Database (Denmark)

    Poulsen, Annemarie

    The aim of this project is to perform an experimental study on the influence of the thermal feedback on the burning behavior of well ventilated pre-flashover fires. For the purpose an experimental method has been developed. Here the same identical objects are tested under free burn conditions...... carried out by Carleton University and NRC-IRC performed on seven different types of fire loads representing commercial premises, comprise the tests used for the study. The results show that for some of the room test the heat release rate increased due to thermal feedback compared to free burn for a pre......-flashover fire. Two phenomena were observed, that relate well to theory was found. In an incipient phase the heat release rate rose with the temperature of the smoke layer/enclosure boundaries. This increase was also found to depend on the flammability properties of the burning object. The results also...

  9. Compact MOSFET models for VLSI design

    CERN Document Server

    Bhattacharyya, A B

    2009-01-01

    Practicing designers, students, and educators in the semiconductor field face an ever expanding portfolio of MOSFET models. In Compact MOSFET Models for VLSI Design , A.B. Bhattacharyya presents a unified perspective on the topic, allowing the practitioner to view and interpret device phenomena concurrently using different modeling strategies. Readers will learn to link device physics with model parameters, helping to close the gap between device understanding and its use for optimal circuit performance. Bhattacharyya also lays bare the core physical concepts that will drive the future of VLSI.

  10. Empirical modelling for the conceptual design and use of products

    OpenAIRE

    Roe, Chris P.; Beynon, Meurig; Fischer, Carlos N

    2001-01-01

    The process of designing an engineering product usually involves only superficial interaction on the part of the user during the design. This often leads to the product being unsuitable for its target comnmnity. In this paper, we describe an approach called Empirical Modelling that emphasises interaction and experiment throughout the construction of a model that we believe has benefits in respect of usability. We use a case study in digital watch design to illustrate our approach and our ideas.

  11. Optimal designs for the Michaelis Menten model with correlated observations

    OpenAIRE

    Dette, Holger; Kunert, Joachim

    2012-01-01

    In this paper we investigate the problem of designing experiments for weighted least squares analysis in the Michaelis Menten model. We study the structure of exact D-optimal designs in a model with an autoregressive error structure. Explicit results for locally D-optimal are derived for the case where 2 observations can be taken per subject. Additionally standardized maximin D-optimal designs are obtained in this case. The results illustrate the enormous difficulties to find e...

  12. A Topological Model for Parallel Algorithm Design

    Science.gov (United States)

    1991-09-01

    New York, 1989. 108. J. Dugundji . Topology . Allen and Bacon, Rockleigh, NJ, 1966. 109. R. Duncan. A Survey of Parallel Computer Architectures. IEEE...Approved for public release; distribition unlimited 4N1f-e AFIT/DS/ENG/91-02 A TOPOLOGICAL MODEL FOR PARALLEL ALGORITHM DESIGN DISSERTATION Presented to...DC 20503. 4. TITLE AND SUBTITLE 5. FUNDING NUMBERS A Topological Model For Parallel Algorithm Design 6. AUTHOR(S) Jeffrey A Simmers, Captain, USAF 7

  13. AEROSOL PARTICLE COLLECTOR DESIGN STUDY

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S; Richard Dimenna, R

    2007-09-27

    A computational evaluation of a particle collector design was performed to evaluate the behavior of aerosol particles in a fast flowing gas stream. The objective of the work was to improve the collection efficiency of the device while maintaining a minimum specified air throughput, nominal collector size, and minimal power requirements. The impact of a range of parameters was considered subject to constraints on gas flow rate, overall collector dimensions, and power limitations. Potential improvements were identified, some of which have already been implemented. Other more complex changes were identified and are described here for further consideration. In addition, fruitful areas for further study are proposed.

  14. Design and Co-design of Project-organized Studies

    DEFF Research Database (Denmark)

    Nielsen, Jørgen Lerche; Andreasen, Lars Birch

    2014-01-01

    The chapter contributes to discussions on design processes in relation to education, presenting different notions of design research and demonstrating how professors and students are involved together in designing innovative and constructive study processes that can help foster students' engageme......, self-awareness, mutual evaluation, reflection, and critical and creative thinking.......The chapter contributes to discussions on design processes in relation to education, presenting different notions of design research and demonstrating how professors and students are involved together in designing innovative and constructive study processes that can help foster students' engagement...

  15. A grand model for chemical product design

    DEFF Research Database (Denmark)

    Fung, Ka Y.; Ng, Ka M.; Zhang, Lei;

    2016-01-01

    Chemical engineering has been expanding its focus from primarily business-to-business products (B2B) to business-to-consumer (B2C) products. The production of B2B products generally emphasizes on process design and optimization, whereas the production of B2C products focuses on product quality......, ingredients and structure. Market and competitive analysis, government policies and regulations have to be explicitly considered in product design. All these considerations are accounted for in the Grand Product Design Model, which consists of a process model, a property model, a quality model, a cost model...... product composition changes with market conditions. Another is a hand lotion that illustrates how product quality affects the profit.(C) 2016 Elsevier Ltd. All rights reserved....

  16. Overview of the Brooklyn traffic real-time ambient pollutant penetration and environmental dispersion (B-TRAPPED) study: theoretical background and model for design of field experiments.

    Science.gov (United States)

    Hahn, Intaek; Wiener, Russell W; Richmond-Bryant, Jennifer; Brixey, Laurie A; Henkle, Stacy W

    2009-12-01

    The Brooklyn traffic real-time ambient pollutant penetration and environmental dispersion (B-TRAPPED) study was a multidisciplinary field research project that investigated the transport, dispersion, and infiltration processes of traffic emission particulate matter (PM) pollutants in a near-highway urban residential area. The urban PM transport, dispersion, and infiltration processes were described mathematically in a theoretical model that was constructed to develop the experimental objectives of the B-TRAPPED study. In the study, simultaneous and continuous time-series PM concentration and meteorological data collected at multiple outdoor and indoor monitoring locations were used to characterize both temporal and spatial patterns of the PM concentration movements within microscale distances (dispersion of PM; (3) studying the influence of meteorological variables on the transport, dispersion, and infiltration processes; (4) characterizing the relationships between the building parameters and the infiltration mechanisms; (5) establishing a cause-and-effect relationship between outdoor-released PM and indoor PM concentrations and identifying the dominant mechanisms involved in the infiltration process; (6) evaluating the effectiveness of a shelter-in-place area for protection against outdoor-released PM pollutants; and (7) understanding the predominant airflow and pollutant dispersion patterns within the neighborhood using wind tunnel and CFD simulations. The 10 papers in this first set of papers presenting the results from the B-TRAPPED study address these objectives. This paper describes the theoretical background and models representing the interrelated processes of transport, dispersion, and infiltration. The theoretical solution for the relationship between the time-dependent indoor PM concentration and the initial PM concentration at the outdoor source was obtained. The theoretical models and solutions helped us to identify important parameters in the

  17. DESIGNING A COMPETITIVE ADVANTAGE MODEL WITH TECHNOLOGY ORIENTED APPROACH USING FAHP TECHNIQUE: A CASE STUDY IN COIL INDUSTRY

    Directory of Open Access Journals (Sweden)

    ABDOLHAMID S. GHADIKOLAEI

    2013-04-01

    Full Text Available One of the distinctive attributes of today’s successful companies is having at least one competitive advantage in one known area. Technological competency is an important advantage which helps improve the firm’s competitiveness. In fact, suitable use of new technologies can dramatically influence the innovation speed, decrease the time of product development cycle and also increase the rate of new product introduction. Firm-specific technological competencies help explain why a firm is different, how it changes over time, and whether it is capable of remaining competitive. In this study, technological competency factors (technology management, process technology, product technology are prioritized according to the competitive advantage levels(customer satisfaction, brand reputation, new product introduction, market share and competitive priorities (cost, price, quality, flexibility, time using fuzzy Analytic hierarchy process (FAHP with the aim of maximizing the nonfinancial performance at coil manufacture industry. The results indicate that within Iran coil industry, process technology is of greater importance than technology management and product technology.

  18. Campus network security model study

    Science.gov (United States)

    Zhang, Yong-ku; Song, Li-ren

    2011-12-01

    Campus network security is growing importance, Design a very effective defense hacker attacks, viruses, data theft, and internal defense system, is the focus of the study in this paper. This paper compared the firewall; IDS based on the integrated, then design of a campus network security model, and detail the specific implementation principle.

  19. MODELING METHOD OF 4D INFORMATION MODEL FOR COOPERATIVE DESIGN OF MECHANICAL PRODUCTS

    Institute of Scientific and Technical Information of China (English)

    TAN Ying; YIN Guofu; HU Ruifei; FANG Hui

    2007-01-01

    The continuous developing features in the design of mechanical product and based on 3D entity model is aimed at, and the extension of the 4-dimensional model with the process of designing, the knowledge described model on the level of semantic understanding and summarizing the designing process and the way of discovering knowledge from multi-information model are studied. On the basis of designing the broad sensed collaborative system, through discussion of the relationship between the implicit knowledge of the users and the designing knowledge as well as commanding all the designing links, taking advantage of the way of concluding and deducting in the concept of the designers, the synthetic knowledge unit formed in the dynamic process from the conception design to the last design is schemed out, and the knowledge discovered principle in the dynamic designing process of the mechanical products and the key technology in its implementation under the milieu of network is brought forward.

  20. Towards Analytical Modeling for Persuasive Design Choices in Mobile Apps

    Directory of Open Access Journals (Sweden)

    Hamid Mukhtar

    2016-11-01

    Full Text Available Persuasive technology has emerged as a new field of research in the past decade with its applications in various domains including web-designing, human-computer interaction, healthcare systems, and social networks. Although persuasive technology has its roots in psychology and cognitive sciences, researchers from the computing disciplines are also increasingly interested in it. Unfortunately, the existing theories, models, and frameworks for persuasive system design fall short due to absence of systematic design processes mostly used in the computing domains as well as lack of support for appropriate post-analysis. This work provides some insight into such limitations and identifies the importance of analytical modeling for persuasion in mobile applications design. The authors illustrate, using a case study, that appropriate mathematical models can be applied together with user modeling to develop a persuasive system that will allow the designer to consider several design choices simultaneously.

  1. Design, Modelling and Analysis of a Workflow Reconfiguration

    DEFF Research Database (Denmark)

    Mazzara, Manuel; Abouzaid, Faisal; Dragoni, Nicola

    2011-01-01

    This paper describes a case study involving the reconfiguration of an office workflow. We state the requirements on a system implementing the workflow and its reconfiguration, and describe the system’s design in BPMN. We then use an asynchronous pi-calculus and Web.1 to model the design and to ve......This paper describes a case study involving the reconfiguration of an office workflow. We state the requirements on a system implementing the workflow and its reconfiguration, and describe the system’s design in BPMN. We then use an asynchronous pi-calculus and Web.1 to model the design...

  2. Developing an analytical model to increase urban security from the Secured perspective by Designing (SBD Approach using fuzzy AHP method (case study: region 17 of Tehran

    Directory of Open Access Journals (Sweden)

    H. Zabihi

    2013-01-01

    DiscussionThis study follows two targets: First, determining the relative importance of criteria and sub-criteria of SBD approach and second, evaluating urban security in four areas of the case study using the results of the previous step. The proposed fuzzy AHP model to achieve mentioned targets is composed of the following steps:Step 1: Identify the criteria and sub-criteria of each principle of SBD approach. Step 2: Structure the AHP model hierarchically based on the criteria and sub-criteria identified at Step 1Step 3: Determine the priorities of the main principles with respect to the goal by using pairwise comparison matrices (w1. This scale is proposed by Kahraman et al. (Kahraman, 2008 and used for solving fuzzy decision making problems (Dagdeviren & Yüksel, 2008; Kahraman, Ertay, & Buyukozkan, 2006; Tolga, Demircan, & Kahraman, 2005 in the literature. Pairwise comparison matrices of the components imported in Microsoft Excel workspace developed for solving FAHP matrices. Step 4: Determine the local weights of the criteria (w2 and sub-criteria (w3 (Local and alternatives. Step 5: Calculate the global weights for the sub-criteria (w3 (Global. Step 6: Compute the overall weight of each alternative (area and choose the best area. 4– ConclusionThis study has been proposed a hierarchical model to evaluate the rate of environmental security which decomposes the 5 principles of SBD into 12 criteria and 29 sub-criteria. To our best knowledge, this is the first time that factors affecting main principles of SBD are determined and prioritized. This may help urban designers to consider the most important factors affecting crime reduction in their designs and decision makings.This model is based on determining the most important factors affecting 5 principles of SBD which can lead to urban security in the case study. For this purpose, fuzzy AHP method is adopted in order to assess the relative importance of the factors and sub factors of the model. This method has the ability

  3. A Study of Curriculums for Occupational Preparation and Education (Scope Program: Phase I). A Systems Model for Instructional Design and Management. Incidental Report #3.

    Science.gov (United States)

    Tuckman, Bruce W.

    A systems model for the design and management of instruction in occupational fields is described. The model is broken down into these phases: (1) analysis, in which occupational tasks are specified via task analysis, tasks are restated as behavioral objectives and a sequence is specified for the objectives, (2) synthesis, in which instructional…

  4. Instructional Design in Education: New Model

    Science.gov (United States)

    Isman, Aytekin

    2011-01-01

    The main goal of the new instructional design model is to organize long term and full learning activities. The new model is based on the theoretical foundation of behaviorism, cognitivism and constructivism. During teaching and learning activities, learners are active and use cognitive, constructivist, or behaviorist learning to construct new…

  5. A first-order thermal model for building design

    Energy Technology Data Exchange (ETDEWEB)

    Mathews, E.H. [Centre for Experimental and Numerical Thermoflow, Univ. of Pretoria (South Africa); Richards, P.G. [Centre for Experimental and Numerical Thermoflow, Univ. of Pretoria (South Africa); Lombard, C. [Centre for Experimental and Numerical Thermoflow, Univ. of Pretoria (South Africa)

    1994-12-31

    Simplified thermal models of buildings can successfully be applied in building design. This paper describes the derivation and validation of a first-order thermal model which has a clear physical interpretation, is based on uncomplicated calculation procedures and requires limited input information. Because extensive simplifications and assumptions are inherent in the development of the model, a comprehensive validation study is reported. The validity of the thermal model was proven with 70 validation studies in 32 buildings comprising a wide range of thermal characteristics. The accuracy of predictions compares well with other sophisticated programs. The proposed model is considered to be eminently suitable for incorporation in an efficient design tool. (orig.)

  6. Models and Modelling Tools for Chemical Product and Process Design

    DEFF Research Database (Denmark)

    Gani, Rafiqul

    2016-01-01

    The design, development and reliability of a chemical product and the process to manufacture it, need to be consistent with the end-use characteristics of the desired product. One of the common ways to match the desired product-process characteristics is through trial and error based experiments......-based framework is that in the design, development and/or manufacturing of a chemical product-process, the knowledge of the applied phenomena together with the product-process design details can be provided with diverse degrees of abstractions and details. This would allow the experimental resources......, are the needed models for such a framework available? Or, are modelling tools that can help to develop the needed models available? Can such a model-based framework provide the needed model-based work-flows matching the requirements of the specific chemical product-process design problems? What types of models...

  7. Model to Design Drip Hose Lateral Line

    Science.gov (United States)

    Ludwig, Rafael; Cury Saad, João Carlos

    2014-05-01

    Introduction The design criterion for non-pressure compensating drip hose is normally to have 10% of flow variation (Δq) in the lateral line, corresponding to 20% of head pressure variation (ΔH). Longer lateral lines in drip irrigation systems using conventional drippers provide cost reduction, but it is necessary to obtain to the uniformity of irrigation [1]. The use of Δq higher levels can provide longer lateral lines. [4] proposes the use of a 30% Δq and he found that this value resulted in distribution uniformity over 80%. [1] considered it is possible to extend the lateral line length using two emitters spacing in different section. He assumed that the spacing changing point would be at 40% of the total length, because this is approximately the location of the average flow according with [2]. [3] found that, for practical purposes, the average pressure is located at 40% of the length of the lateral line and that until this point it has already consumed 75% of total pressure head loss (hf ). In this case, the challenge for designers is getting longer lateral lines with high values of uniformity. Objective The objective of this study was to develop a model to design longer lateral lines using non-pressure compensating drip hose. Using the developed model, the hypotheses to be evaluated were: a) the use of two different spacing between emitters in the same lateral line allows longer length; b) it is possible to get longer lateral lines using high values of pressure variation in the lateral lines since the distribution uniformity stays below allowable limits. Methodology A computer program was developed in Delphi® based on the model developed and it is able to design lateral lines in level using non-pressure compensating drip hose. The input data are: desired distribution uniformity (DU); initial and final pressure in the lateral line; coefficients of relationship between emitter discharge and pressure head; hose internal diameter; pipe cross-sectional area

  8. HTS Insert Magnet Design Study

    CERN Document Server

    Devaux, M; Fleiter, J; Fazilleau, P; Lécrevisse, T; Pes, C; Rey, J-M; Rifflet, J-M; Sorbi, M; Stenvall, A; Tixador, P; Volpini, G

    2011-01-01

    Future accelerator magnets will need to reach higher field in the range of 20 T. This field level is very difficult to reach using only Low Temperature Superconductor materials whereas High Temperature Superconductors (HTS) provide interesting opportunities. High current densities and stress levels are needed to design such magnets. YBCO superconductor indeed carries large current densities under high magnetic field and provides good mechanical properties especially when produced using the IBAD approach. The HFM EUCARD program studies the design and the realization of an HTS insert of 6 T inside a Nb3Sn dipole of 13T at 4.2 K. In the2HTS insert, engineering current densities higher than 250 MA/m under 19 T are required to fulfill the specifications. The stress level is also very severe. YBCO IBAD tapes theoretically meet these challenges from presented measurements. The insert protection is also a critical because HTS materials show low quench propagation velocities and the coupling with the Nb3Sn magnet make...

  9. Propulsion System Models for Rotorcraft Conceptual Design

    Science.gov (United States)

    Johnson, Wayne

    2014-01-01

    The conceptual design code NDARC (NASA Design and Analysis of Rotorcraft) was initially implemented to model conventional rotorcraft propulsion systems, consisting of turboshaft engines burning jet fuel, connected to one or more rotors through a mechanical transmission. The NDARC propulsion system representation has been extended to cover additional propulsion concepts, including electric motors and generators, rotor reaction drive, turbojet and turbofan engines, fuel cells and solar cells, batteries, and fuel (energy) used without weight change. The paper describes these propulsion system components, the architecture of their implementation in NDARC, and the form of the models for performance and weight. Requirements are defined for improved performance and weight models of the new propulsion system components. With these new propulsion models, NDARC can be used to develop environmentally-friendly rotorcraft designs.

  10. Product Data Model for Performance-driven Design

    Science.gov (United States)

    Hu, Guang-Zhong; Xu, Xin-Jian; Xiao, Shou-Ne; Yang, Guang-Wu; Pu, Fan

    2017-09-01

    When designing large-sized complex machinery products, the design focus is always on the overall performance; however, there exist no design theory and method based on performance driven. In view of the deficiency of the existing design theory, according to the performance features of complex mechanical products, the performance indices are introduced into the traditional design theory of "Requirement-Function-Structure" to construct a new five-domain design theory of "Client Requirement-Function-Performance-Structure-Design Parameter". To support design practice based on this new theory, a product data model is established by using performance indices and the mapping relationship between them and the other four domains. When the product data model is applied to high-speed train design and combining the existing research result and relevant standards, the corresponding data model and its structure involving five domains of high-speed trains are established, which can provide technical support for studying the relationships between typical performance indices and design parameters and the fast achievement of a high-speed train scheme design. The five domains provide a reference for the design specification and evaluation criteria of high speed train and a new idea for the train's parameter design.

  11. Diagnostic study, design and implementation of an integrated model of care in France: a bottom-up process with continuous leadership

    Directory of Open Access Journals (Sweden)

    Matthieu de Stampa

    2010-02-01

    Full Text Available Background: Sustaining integrated care is difficult, in large part because of problems encountered securing the participation of health care and social service professionals and, in particular, general practitioners (GPs. Purpose: To present an innovative bottom-up and pragmatic strategy used to implement a new integrated care model in France for community-dwelling elderly people with complex needs. Results: In the first step, a diagnostic study was conducted with face-to-face interviews to gather data on current practices from a sample of health and social stakeholders working with elderly people. In the second step, an integrated care model called Coordination Personnes Agées (COPA was designed by the same major stakeholders in order to define its detailed characteristics based on the local context. In the third step, the model was implemented in two phases: adoption and maintenance. This strategy was carried out by a continuous and flexible leadership throughout the process, initially with a mixed leadership (clinician and researcher followed by a double one (clinician and managers of services in the implementation phase. Conclusion: The implementation of this bottom-up and pragmatic strategy relied on establishing a collaborative dynamic among health and social stakeholders. This enhanced their involvement throughout the implementation phase, particularly among the GPs, and allowed them to support the change practices and services arrangements

  12. Diagnostic study, design and implementation of an integrated model of care in France: a bottom-up process with continuous leadership

    Directory of Open Access Journals (Sweden)

    Matthieu de Stampa

    2010-02-01

    Full Text Available Background: Sustaining integrated care is difficult, in large part because of problems encountered securing the participation of health care and social service professionals and, in particular, general practitioners (GPs. Purpose: To present an innovative bottom-up and pragmatic strategy used to implement a new integrated care model in France for community-dwelling elderly people with complex needs.Results: In the first step, a diagnostic study was conducted with face-to-face interviews to gather data on current practices from a sample of health and social stakeholders working with elderly people. In the second step, an integrated care model called Coordination Personnes Agées (COPA was designed by the same major stakeholders in order to define its detailed characteristics based on the local context. In the third step, the model was implemented in two phases: adoption and maintenance. This strategy was carried out by a continuous and flexible leadership throughout the process, initially with a mixed leadership (clinician and researcher followed by a double one (clinician and managers of services in the implementation phase.Conclusion: The implementation of this bottom-up and pragmatic strategy relied on establishing a collaborative dynamic among health and social stakeholders. This enhanced their involvement throughout the implementation phase, particularly among the GPs, and allowed them to support the change practices and services arrangements

  13. Linguistic granular model: design and realization

    Institute of Scientific and Technical Information of China (English)

    YUE Shihong; LI Ping; SONG Zhihuan

    2005-01-01

    A new linguistic granular model is proposed and the effect of its parameters on the output is analyzed. The design of the model consists of two stages: using conditional fuzzy clustering for information granular, and integrating all information granules to final output. The integrating tool is fuzzy integral based on fuzzy measure, and the generalization of fuzzy integral increases flexibility of the linguistic granular model greatly. A heuristic algorithm to determine the parameters in the fuzzy integral is used to realize the linguistic model. Two experiments verify the feasibility of the proposed model.

  14. Architectural Design Document for Camera Models

    DEFF Research Database (Denmark)

    Thuesen, Gøsta

    1998-01-01

    Architecture of camera simulator models and data interface for the Maneuvering of Inspection/Servicing Vehicle (MIV) study.......Architecture of camera simulator models and data interface for the Maneuvering of Inspection/Servicing Vehicle (MIV) study....

  15. Architectural Design Document for Camera Models

    DEFF Research Database (Denmark)

    Thuesen, Gøsta

    1998-01-01

    Architecture of camera simulator models and data interface for the Maneuvering of Inspection/Servicing Vehicle (MIV) study.......Architecture of camera simulator models and data interface for the Maneuvering of Inspection/Servicing Vehicle (MIV) study....

  16. Valorization of Crataegus azarolus stones for the removal of textile anionic dye by central composite rotatable design using cubic model: optimization, isotherm, and kinetic studies.

    Science.gov (United States)

    Boudechiche, Noreddine; Yazid, Hynda; Trari, Mohamed; Sadaoui, Zahra

    2017-07-05

    In this study, the central composite rotatable design (CCRD) was used in the optimization of the operating parameters for the removal of the direct blue 86 (DB86), an anionic dye, because of its hazardous impact on human health and aquatic environment. In addition, DB86 is a recalcitrant and non-biodegradable dye whose presence considerably inhibits photosynthesis. Its removal in aqueous medium was achieved by biosorption onto the novel biosorbent Crataegus azarolus stones (CAS). The parameters like the solution pH, biosorbent dose, initial DB86 concentration, and temperature were studied in the ranges 2-6, 0.8-4 g L(-1), 20-100 mg L(-1), and 10-50 °C, respectively. The significance of the experimental parameters and their interactions was investigated by the Student's t test and p values with 5% error limits using JMP 11.0.0 software. The regression analysis of the experimental data obtained from 31 batch runs provides a cubic model. The optimum conditions obtained for the maximum DB86 elimination from the synthetic solution were found to be pH 2, biosorbent dose of 4 g L(-1), initial DB86 concentration of 20 mg L(-1), and temperature of 10 °C, leading to a theoretical maximum removal of 123%. The experimental data were analyzed by the Langmuir, Freundlich, and Temkin equilibrium models. The Langmuir isotherm gave the best fit with a maximum biosorption capacity of 24.02 mg g(-1). The results of the kinetic study revealed that the biosorption kinetic of DB86 follows a pseudo-second-order model. All results confirmed that CAS are an efficient, economic, and ecological alternative for the treatment of industrial wastewaters loaded with anionic dyes.

  17. Panoramic imaging perimeter sensor design and modeling

    Energy Technology Data Exchange (ETDEWEB)

    Pritchard, D.A.

    1993-12-31

    This paper describes the conceptual design and preliminary performance modeling of a 360-degree imaging sensor. This sensor combines automatic perimeter intrusion detection with immediate visual assessment and is intended to be used for fast deployment around fixed or temporary high-value assets. The sensor requirements, compiled from various government agencies, are summarized. The conceptual design includes longwave infrared and visible linear array technology. An auxiliary millimeter-wave sensing technology is also considered for use during periods of infrared and visible obscuration. The infrared detectors proposed for the sensor design are similar to the Standard Advanced Dewar Assembly Types Three A and B (SADA-IIIA/B). An overview of the sensor and processor is highlighted. The infrared performance of this sensor design has been predicted using existing thermal imaging system models and is described in the paper. Future plans for developing a prototype are also presented.

  18. Development and validation of a building design waste reduction model.

    Science.gov (United States)

    Llatas, C; Osmani, M

    2016-10-01

    Reduction in construction waste is a pressing need in many countries. The design of building elements is considered a pivotal process to achieve waste reduction at source, which enables an informed prediction of their wastage reduction levels. However the lack of quantitative methods linking design strategies to waste reduction hinders designing out waste practice in building projects. Therefore, this paper addresses this knowledge gap through the design and validation of a Building Design Waste Reduction Strategies (Waste ReSt) model that aims to investigate the relationships between design variables and their impact on onsite waste reduction. The Waste ReSt model was validated in a real-world case study involving 20 residential buildings in Spain. The validation process comprises three stages. Firstly, design waste causes were analyzed. Secondly, design strategies were applied leading to several alternative low waste building elements. Finally, their potential source reduction levels were quantified and discussed within the context of the literature. The Waste ReSt model could serve as an instrumental tool to simulate designing out strategies in building projects. The knowledge provided by the model could help project stakeholders to better understand the correlation between the design process and waste sources and subsequently implement design practices for low-waste buildings.

  19. Novel Compressor Blade Design Study

    Science.gov (United States)

    Srinivas, Abhay

    Jet engine efficiency goals are driving compressors to higher pressure ratios and engines to higher bypass ratios, each one driving to smaller cores. This is leading to larger tip gaps relative to the blade height. These larger relative tip clearances would negate some of the cycle improvements, and ways to mitigate this effect must be found. A novel split tip blade geometry has been created which helps improve the efficiency at large clearances while also improving operating range. Two identical blades are leaned in opposite directions starting at 85% span. They are cut at mid chord and the 2 halves then merged together so a split tip is created. The result is similar to the alula feathers on a soaring bird. The concept is that the split tip will energize the tip flow and increase range. For higher relative tip clearance, this will also improve efficiency. The 6th rotor of a highly loaded 10 stage machine was chosen as the baseline for this study. Three dimensional CFD simulations were performed using CD Adapco's Star-CCM+ at 5 clearances for the baseline and split tip geometry. The choking flow and stall margin of the split tip blade was higher than that of the baseline blade for all tip clearances. The pressure ratio of the novel blade was higher than that of the baseline blade near choke, but closer to stall it decreased. The sensitivity of peak efficiency to clearance was improved. At tight clearances of 0.62% of blade height, the maximum efficiency of the new design was less than the baseline blade, but as the tip clearance was increased above 2.5%, the maximum efficiency increased. Structural analysis was also performed to ascertain the feasibility of the design.

  20. Modeling Forensic Evidence Systems Using Design Science

    OpenAIRE

    Armstrong, Colin; Armstrong, Helen

    2010-01-01

    International audience; This paper presents an overview of the application of design science research to the tactical management of forensic evidence processing. The opening discussion addresses the application of design science techniques to specific socio-technical information systems research in regard to processing forensic evidence. The discussion then presents the current problems faced by those dealing with evidence and a conceptual meta-model for a unified approach to forensic evidenc...

  1. Computer Aided Design Modeling for Heterogeneous Objects

    CERN Document Server

    Gupta, Vikas; Tandon, Puneet

    2010-01-01

    Heterogeneous object design is an active research area in recent years. The conventional CAD modeling approaches only provide geometry and topology of the object, but do not contain any information with regard to the materials of the object and so can not be used for the fabrication of heterogeneous objects (HO) through rapid prototyping. Current research focuses on computer-aided design issues in heterogeneous object design. A new CAD modeling approach is proposed to integrate the material information into geometric regions thus model the material distributions in the heterogeneous object. The gradient references are used to represent the complex geometry heterogeneous objects which have simultaneous geometry intricacies and accurate material distributions. The gradient references helps in flexible manipulability and control to heterogeneous objects, which guarantees the local control over gradient regions of developed heterogeneous objects. A systematic approach on data flow, processing, computer visualizat...

  2. Conceptual design interpretations, mindset and models

    CERN Document Server

    Andreasen, Mogens Myrup; Cash, Philip

    2015-01-01

    Maximising reader insights into the theory, models, methods and fundamental reasoning of design, this book addresses design activities in industrial settings, as well as the actors involved. This approach offers readers a new understanding of design activities and related functions, properties and dispositions. Presenting a ‘design mindset’ that seeks to empower students, researchers, and practitioners alike, it features a strong focus on how designers create new concepts to be developed into products, and how they generate new business and satisfy human needs.   Employing a multi-faceted perspective, the book supplies the reader with a comprehensive worldview of design in the form of a proposed model that will empower their activities as student, researcher or practitioner. We draw the reader into the core role of design conceptualisation for society, for the development of industry, for users and buyers of products, and for citizens in relation to public systems. The book also features original con...

  3. Designing and evaluating representations to model pedagogy

    Directory of Open Access Journals (Sweden)

    Elizabeth Masterman

    2013-08-01

    Full Text Available This article presents the case for a theory-informed approach to designing and evaluating representations for implementation in digital tools to support Learning Design, using the framework of epistemic efficacy as an example. This framework, which is rooted in the literature of cognitive psychology, is operationalised through dimensions of fit that attend to: (1 the underlying ontology of the domain, (2 the purpose of the task that the representation is intended to facilitate, (3 how best to support the cognitive processes of the users of the representations, (4 users’ differing needs and preferences, and (5 the tool and environment in which the representations are constructed and manipulated.Through showing how epistemic efficacy can be applied to the design and evaluation of representations, the article presents the Learning Designer, a constructionist microworld in which teachers can both assemble their learning designs and model their pedagogy in terms of students’ potential learning experience. Although the activity of modelling may add to the cognitive task of design, the article suggests that the insights thereby gained can additionally help a lecturer who wishes to reuse a particular learning design to make informed decisions about its value to their practice.

  4. PROPOSAL OF A MODEL MANAGEMENT TO SMALL DESIGN COMPANIES

    Directory of Open Access Journals (Sweden)

    Otávio José de OLIVEIRA

    2008-11-01

    Full Text Available The main purpose of this paper is the proposition of a management model specifically developed for small building design firms, aligned with their needs and particularities. The field research was conducted with a qualitative approach through the analysis of four case studies in small building design firms acting mainly in São Paulo City. The data collection was accomplished through semi-structured interviews, direct observation and analysis of documents. The proposed model includes guidance to the management of the core processes and activities of small building design firms, such as: organizational structure; strategic planning; planning and control of design process; costs management; sales management; information systems; human resources management; services added to the design; and performance evaluation. Key-words: design firms; design process; building construction.

  5. Design, modeling and testing of data converters

    CERN Document Server

    Kiaei, Sayfe; Xu, Fang

    2014-01-01

    This book presents the a scientific discussion of the state-of-the-art techniques and designs for modeling, testing and for the performance analysis of data converters. The focus is put on sustainable data conversion. Sustainability has become a public issue that industries and users can not ignore. Devising environmentally friendly solutions for data conversion designing, modeling and testing is nowadays a requirement that researchers and practitioners must consider in their activities. This book presents the outcome of the IWADC workshop 2011, held in Orvieto, Italy.

  6. Design of reconfigurable antennas using graph models

    CERN Document Server

    Costantine, Joseph; Christodoulou, Christos G; Christodoulou, Christos G

    2013-01-01

    This lecture discusses the use of graph models to represent reconfigurable antennas. The rise of antennas that adapt to their environment and change their operation based on the user's request hasn't been met with clear design guidelines. There is a need to propose some rules for the optimization of any reconfigurable antenna design and performance. Since reconfigurable antennas are seen as a collection of self-organizing parts, graph models can be introduced to relate each possible topology to a corresponding electromagnetic performance in terms of achieving a characteristic frequency of oper

  7. Consistent Stochastic Modelling of Meteocean Design Parameters

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Sterndorff, M. J.

    2000-01-01

    Consistent stochastic models of metocean design parameters and their directional dependencies are essential for reliability assessment of offshore structures. In this paper a stochastic model for the annual maximum values of the significant wave height, and the associated wind velocity, current...... velocity, and water level is presented. The stochastic model includes statistical uncertainty and dependency between the four stochastic variables. Further, a new stochastic model for annual maximum directional significant wave heights is presented. The model includes dependency between the maximum wave...... height from neighboring directional sectors. Numerical examples are presented where the models are calibrated using the Maximum Likelihood method to data from the central part of the North Sea. The calibration of the directional distributions is made such that the stochastic model for the omnidirectional...

  8. ACSA: Conference book: Design Studies

    NARCIS (Netherlands)

    Van Duin, L.

    1992-01-01

    In recent years, the Faculty of Architecture, Housing, Urban Design and Planning has been undergoing large changes in the training and research program mes. These changes followon from the signals received from professional practice, but above all from the desire of staff and students to design prog

  9. Organizational Learning and Product Design Management: Towards a Theoretical Model.

    Science.gov (United States)

    Chiva-Gomez, Ricardo; Camison-Zornoza, Cesar; Lapiedra-Alcami, Rafael

    2003-01-01

    Case studies of four Spanish ceramics companies were used to construct a theoretical model of 14 factors essential to organizational learning. One set of factors is related to the conceptual-analytical phase of the product design process and the other to the creative-technical phase. All factors contributed to efficient product design management…

  10. Design Approaches to Support Preservice Teachers in Scientific Modeling

    Science.gov (United States)

    Kenyon, Lisa; Davis, Elizabeth A.; Hug, Barbara

    2011-02-01

    Engaging children in scientific practices is hard for beginning teachers. One such scientific practice with which beginning teachers may have limited experience is scientific modeling. We have iteratively designed preservice teacher learning experiences and materials intended to help teachers achieve learning goals associated with scientific modeling. Our work has taken place across multiple years at three university sites, with preservice teachers focused on early childhood, elementary, and middle school teaching. Based on results from our empirical studies supporting these design decisions, we discuss design features of our modeling instruction in each iteration. Our results suggest some successes in supporting preservice teachers in engaging students in modeling practice. We propose design principles that can guide science teacher educators in incorporating modeling in teacher education.

  11. NUMERICAL MODEL APPLICATION IN ROWING SIMULATOR DESIGN

    Directory of Open Access Journals (Sweden)

    Petr Chmátal

    2016-04-01

    Full Text Available The aim of the research was to carry out a hydraulic design of rowing/sculling and paddling simulator. Nowadays there are two main approaches in the simulator design. The first one includes a static water with no artificial movement and counts on specially cut oars to provide the same resistance in the water. The second approach, on the other hand uses pumps or similar devices to force the water to circulate but both of the designs share many problems. Such problems are affecting already built facilities and can be summarized as unrealistic feeling, unwanted turbulent flow and bad velocity profile. Therefore, the goal was to design a new rowing simulator that would provide nature-like conditions for the racers and provide an unmatched experience. In order to accomplish this challenge, it was decided to use in-depth numerical modeling to solve the hydraulic problems. The general measures for the design were taken in accordance with space availability of the simulator ́s housing. The entire research was coordinated with other stages of the construction using BIM. The detailed geometry was designed using a numerical model in Ansys Fluent and parametric auto-optimization tools which led to minimum negative hydraulic phenomena and decreased investment and operational costs due to the decreased hydraulic losses in the system.

  12. Fuel Cell Power Model Version 2: Startup Guide, System Designs, and Case Studies. Modeling Electricity, Heat, and Hydrogen Generation from Fuel Cell-Based Distributed Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Steward, D.; Penev, M.; Saur, G.; Becker, W.; Zuboy, J.

    2013-06-01

    This guide helps users get started with the U.S. Department of Energy/National Renewable Energy Laboratory Fuel Cell Power (FCPower) Model Version 2, which is a Microsoft Excel workbook that analyzes the technical and economic aspects of high-temperature fuel cell-based distributed energy systems with the aim of providing consistent, transparent, comparable results. This type of energy system would provide onsite-generated heat and electricity to large end users such as hospitals and office complexes. The hydrogen produced could be used for fueling vehicles or stored for later conversion to electricity.

  13. A Systems Analysis and Design Case Study for a Business Modeling Learning Experience for a Capstone CIS/IS Systems Development Class

    Science.gov (United States)

    Russell, Jack; Russell, Barbara

    2015-01-01

    The goal is to provide a robust and challenging problem statement for a capstone, advanced systems analysis and design course for CIS/MIS/CS majors. In addition to the problem narrative, a representative solution for much of the business modeling deliverables is presented using the UML paradigm. A structured analysis deliverable will be the topic…

  14. Design and Simulation of Toroidal Twister Model

    Institute of Scientific and Technical Information of China (English)

    TIAN Huifang; LIN Xizhen; ZENG Qinqin

    2006-01-01

    Toroidal composite vessel winded with fiber is a new kind of structural pressure vessels, which not only has high structure efficiency of compound materials pressure vessel, good security and so on, but also has special shape and the property of utilizing toroidal space, and the prospect of the application of toroidal composite vessel winded with fiber is extremely broad. By introducing parameters establishment of toroidal vessel and elaborating the principle of filament winding for toroidal vessel, the design model of filament winding machine for toroidal vessel has been introduced, and the design model has been dynamically simulated by the software of ADAMS, which will give more referrence for the design of real toroidal vessel twister.

  15. Optimal Experimental Design for Model Discrimination

    Science.gov (United States)

    Myung, Jay I.; Pitt, Mark A.

    2009-01-01

    Models of a psychological process can be difficult to discriminate experimentally because it is not easy to determine the values of the critical design variables (e.g., presentation schedule, stimulus structure) that will be most informative in differentiating them. Recent developments in sampling-based search methods in statistics make it…

  16. Modeling and simulation for RF system design

    CERN Document Server

    Frevert, Ronny; Jancke, Roland; Knöchel, Uwe; Schwarz, Peter; Kakerow, Ralf; Darianian, Mohsen

    2005-01-01

    Focusing on RF specific modeling and simulation methods, and system and circuit level descriptions, this work contains application-oriented training material. Accompanied by a CD- ROM, it combines the presentation of a mixed-signal design flow, an introduction into VHDL-AMS and Verilog-A, and the application of commercially available simulators.

  17. Models and Algorithm for Stochastic Network Designs

    Institute of Scientific and Technical Information of China (English)

    Anthony Chen; Juyoung Kim; Seungjae Lee; Jaisung Choi

    2009-01-01

    The network design problem (NDP) is one of the most difficult and challenging problems in trans-portation. Traditional NDP models are often posed as a deterministic bilevel program assuming that all rele-vant inputs are known with certainty. This paper presents three stochastic models for designing transporta-tion networks with demand uncertainty. These three stochastic NDP models were formulated as the ex-pected value model, chance-constrained model, and dependent-chance model in a bilevel programming framework using different criteria to hedge against demand uncertainty. Solution procedures based on the traffic assignment algorithm, genetic algorithm, and Monte-Cado simulations were developed to solve these stochastic NDP models. The nonlinear and nonconvex nature of the bilevel program was handled by the genetic algorithm and traffic assignment algorithm, whereas the stochastic nature was addressed through simulations. Numerical experiments were conducted to evaluate the applicability of the stochastic NDP models and the solution procedure. Results from the three experiments show that the solution procedures are quite robust to different parameter settings.

  18. A genetic algorithm for solving supply chain network design model

    Science.gov (United States)

    Firoozi, Z.; Ismail, N.; Ariafar, S. H.; Tang, S. H.; Ariffin, M. K. M. A.

    2013-09-01

    Network design is by nature costly and optimization models play significant role in reducing the unnecessary cost components of a distribution network. This study proposes a genetic algorithm to solve a distribution network design model. The structure of the chromosome in the proposed algorithm is defined in a novel way that in addition to producing feasible solutions, it also reduces the computational complexity of the algorithm. Computational results are presented to show the algorithm performance.

  19. MODELING PARADOXES IN NOVICE AND EXPERT DESIGN

    DEFF Research Database (Denmark)

    Dorst, Kees; Hansen, Claus Thorp

    2011-01-01

    In their ICED09 paper ‘Problem formulation as a discursive activity’, the authors have used an extensive educational case study to explore a framework for describing design as a discursive activity, centered around the paradoxical nature of the problem situation. The ‘working definition’ for para...... at play in a design situation, and extract themes that can lead to reformulation of the problem as well as the creation of innovative solutions. This behaviour is compared to the ways of working of novice designers (students) in the original case study....

  20. Regional hyperthermia applicator design using FDTD modelling.

    Science.gov (United States)

    Kroeze, H; Van de Kamer, J B; De Leeuw, A A; Lagendijk, J J

    2001-07-01

    Recently published results confirm the positive effect of regional hyperthermia combined with external radiotherapy on pelvic tumours. Several studies have been published on the improvement of RF annular array applicator systems with dipoles and a closed water bolus. This study investigates the performance of a next-generation applicator system for regional hyperthermia with a multi-ring annular array of antennas and an open water bolus. A cavity slot antenna is introduced to enhance the directivity and reduce mutual coupling between the antennas. Several design parameters, i.e. dimensions, number of antennas and operating frequency, have been evaluated using several patient models. Performance indices have been defined to evaluate the effect of parameter variation on the specific absorption rate (SAR) distribution. The performance of the new applicator type is compared with the Coaxial TEM. Operating frequency appears to be the main parameter with a positive influence on the performance. A SAR increase in tumour of 1.7 relative to the Coaxial TEM system can be obtained with a three-ring, six-antenna per ring cavity slot applicator operating at 150 MHz.

  1. Designing visual displays and system models for safe reactor operations

    Energy Technology Data Exchange (ETDEWEB)

    Brown-VanHoozer, S.A.

    1995-12-31

    The material presented in this paper is based on two studies involving the design of visual displays and the user`s prospective model of a system. The studies involve a methodology known as Neuro-Linguistic Programming and its use in expanding design choices from the operator`s perspective image. The contents of this paper focuses on the studies and how they are applicable to the safety of operating reactors.

  2. Study and Design of LED Lighting Systems

    Directory of Open Access Journals (Sweden)

    Li Cheng

    2013-06-01

    Full Text Available In this study, the optical characteristics, thermal characteristics, electrical characteristics of the LED device are studied. After analysis of the significance of the optical model, we establish the model of the LED light source using optical simulation software to analyze the impact of modeling four factors and law, based on ray tracing model intensity distribution with the manufacturers. On this basis, we expand the LED secondary optical design, namely, increasing of LDE method to the light level. After comparing different forms of non-imaging optical components, combined with the actual situation, the final choice is the system composed of rotating parabolic reflector with LDE. Besides, the reflected changing the relative position of the body and LDE space lead to the normal light intensity of the entire system appearing two peaks, but their causes are different. In addition, the method of combining theoretical analysis and computer simulations to study the distribution of LDE array illumination is utilized. Formula on the illumination distribution in the LDB array to a plane parallel thereto is deduced, which is verified by computer simulation and agrees well with it. A quantitative study of the factors affecting the road surface illuminance distribution is made on the basis of previous study, combined with the actual road lighting works. These factors are: LDE array form, the number of LED, spacing between LDE, LDE interval between the street lamps. The derived entire road illumination distribution formula and the corresponding curve gives a basic method for the analysis of such practical problems related outcomes for the LDE illumination optical system design and research basis.

  3. An investigation of modelling and design for software service applications

    Science.gov (United States)

    2017-01-01

    Software services offer the opportunity to use a component-based approach for the design of applications. However, this needs a deeper understanding of how to develop service-based applications in a systematic manner, and of the set of properties that need to be included in the ‘design model’. We have used a realistic application to explore systematically how service-based designs can be created and described. We first identified the key properties of an SOA (service oriented architecture) and then undertook a single-case case study to explore its use in the development of a design for a large-scale application in energy engineering, modelling this with existing notations wherever possible. We evaluated the resulting design model using two walkthroughs with both domain and application experts. We were able to successfully develop a design model around the ten properties identified, and to describe it by adapting existing design notations. A component-based approach to designing such systems does appear to be feasible. However, it needs the assistance of a more integrated set of notations for describing the resulting design model. PMID:28489905

  4. Green Diesel from Hydrotreated Vegetable Oil Process Design Study

    NARCIS (Netherlands)

    Hilbers, T.J.; Sprakel, L.M.J.; Enk, van den L.B.J.; Zaalberg, B.; Berg, van den H.; Ham, van der A.G.J.

    2015-01-01

    A systematic approach was applied to study the process of hydrotreating vegetable oils. During the three phases of conceptual, detailed, and final design, unit operations were designed and sized. Modeling of the process was performed with UniSim Design®. Producing green diesel and jet fuel from vege

  5. Green Diesel from Hydrotreated Vegetable Oil Process Design Study

    NARCIS (Netherlands)

    Hilbers, T.J.; Sprakel, Lisette Maria Johanna; van den Enk, L.B.J.; Zaalberg, B.; van den Berg, Henderikus; van der Ham, Aloysius G.J.

    2015-01-01

    A systematic approach was applied to study the process of hydrotreating vegetable oils. During the three phases of conceptual, detailed, and final design, unit operations were designed and sized. Modeling of the process was performed with UniSim Design®. Producing green diesel and jet fuel from

  6. Engineering design of systems models and methods

    CERN Document Server

    Buede, Dennis M

    2009-01-01

    The ideal introduction to the engineering design of systems-now in a new edition. The Engineering Design of Systems, Second Edition compiles a wealth of information from diverse sources to provide a unique, one-stop reference to current methods for systems engineering. It takes a model-based approach to key systems engineering design activities and introduces methods and models used in the real world. Features new to this edition include: * The addition of Systems Modeling Language (SysML) to several of the chapters, as well as the introduction of new terminology * Additional material on partitioning functions and components * More descriptive material on usage scenarios based on literature from use case development * Updated homework assignments * The software product CORE (from Vitech Corporation) is used to generate the traditional SE figures and the software product MagicDraw UML with SysML plugins (from No Magic, Inc.) is used for the SysML figures This book is designed to be an introductory reference ...

  7. GROUT HOPPER MODELING STUDY

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S.

    2011-08-30

    The Saltstone facility has a grout hopper tank to provide agitator stirring of the Saltstone feed materials. The tank has about 300 gallon capacity to provide a larger working volume for the grout slurry to be held in case of a process upset, and it is equipped with a mechanical agitator, which is intended to keep the grout in motion and agitated so that it won't start to set up. The dry feeds and the salt solution are already mixed in the mixer prior to being transferred to the hopper tank. The hopper modeling study through this work will focus on fluid stirring and agitation, instead of traditional mixing in the literature, in order to keep the tank contents in motion during their residence time so that they will not be upset or solidified prior to transferring the grout to the Saltstone disposal facility. The primary objective of the work is to evaluate the flow performance for mechanical agitators to prevent vortex pull-through for an adequate stirring of the feed materials and to estimate an agitator speed which provides acceptable flow performance with a 45{sup o} pitched four-blade agitator. In addition, the power consumption required for the agitator operation was estimated. The modeling calculations were performed by taking two steps of the Computational Fluid Dynamics (CFD) modeling approach. As a first step, a simple single-stage agitator model with 45{sup o} pitched propeller blades was developed for the initial scoping analysis of the flow pattern behaviors for a range of different operating conditions. Based on the initial phase-1 results, the phase-2 model with a two-stage agitator was developed for the final performance evaluations. A series of sensitivity calculations for different designs of agitators and operating conditions have been performed to investigate the impact of key parameters on the grout hydraulic performance in a 300-gallon hopper tank. For the analysis, viscous shear was modeled by using the Bingham plastic approximation

  8. GROUT HOPPER MODELING STUDY

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S.

    2011-08-30

    The Saltstone facility has a grout hopper tank to provide agitator stirring of the Saltstone feed materials. The tank has about 300 gallon capacity to provide a larger working volume for the grout slurry to be held in case of a process upset, and it is equipped with a mechanical agitator, which is intended to keep the grout in motion and agitated so that it won't start to set up. The dry feeds and the salt solution are already mixed in the mixer prior to being transferred to the hopper tank. The hopper modeling study through this work will focus on fluid stirring and agitation, instead of traditional mixing in the literature, in order to keep the tank contents in motion during their residence time so that they will not be upset or solidified prior to transferring the grout to the Saltstone disposal facility. The primary objective of the work is to evaluate the flow performance for mechanical agitators to prevent vortex pull-through for an adequate stirring of the feed materials and to estimate an agitator speed which provides acceptable flow performance with a 45{sup o} pitched four-blade agitator. In addition, the power consumption required for the agitator operation was estimated. The modeling calculations were performed by taking two steps of the Computational Fluid Dynamics (CFD) modeling approach. As a first step, a simple single-stage agitator model with 45{sup o} pitched propeller blades was developed for the initial scoping analysis of the flow pattern behaviors for a range of different operating conditions. Based on the initial phase-1 results, the phase-2 model with a two-stage agitator was developed for the final performance evaluations. A series of sensitivity calculations for different designs of agitators and operating conditions have been performed to investigate the impact of key parameters on the grout hydraulic performance in a 300-gallon hopper tank. For the analysis, viscous shear was modeled by using the Bingham plastic approximation

  9. Integrating Design Decision Management with Model-based Software Development

    DEFF Research Database (Denmark)

    Könemann, Patrick

    Design decisions are continuously made during the development of software systems and are important artifacts for design documentation. Dedicated decision management systems are often used to capture such design knowledge. Most such systems are, however, separated from the design artifacts...... of the system. In model-based software development, where design models are used to develop a software system, outcomes of many design decisions have big impact on design models. The realization of design decisions is often manual and tedious work on design models. Moreover, keeping design models consistent...

  10. Use of UHPC in Bridge Structures: Material Modeling and Design

    Directory of Open Access Journals (Sweden)

    Oguz Gunes

    2012-01-01

    Full Text Available Ultra-high-performance concrete (UHPC is a promising new class of concrete material that is likely to make a significant contribution to addressing the challenges associated with the load capacity, durability, sustainability, economy, and environmental impact of concrete bridge infrastructures. This paper focuses on the material modeling of UHPC and design of bridge girders made of UHPC. A two-phase model used for modeling the behavior of UHPC was briefly discussed, and the model was implemented in a preliminary design case study. Based on the implemented design and the reported use of UHPC in bridge applications, the advantages, limitations, and future prospects of UHPC bridges were discussed, highlighting the need for innovative research and design to make optimum use of the favorable properties of the material in bridge structures.

  11. X-ray tubes study and design

    CERN Document Server

    Sardari, D

    1990-01-01

    This thesis contain both theoretical and experimental works. Theoretical aspect includes X-Ray tubes case study and design principles, in the introduced design process, anode-cathode distance, vacuum needed, filament size, anode face angle and shape and size of focusing electrodes can be found. A method for specification of tungsten lager thickness on anode is also introduced. Using computer simulation, electron trajectory between cathode-anode is obtained, This work is presented in the first International Conference on Control and Modeling, Tehran, 1990. Experimental work contains manufacturing more than 10 tubes and test each of them. One of these tubes can with stand up to 50 KV. Filament can be heated by passing a 2.1 A current. In these conditions anode current is 1.2 m A. Using this tube, some radiographs have been taken.

  12. Crossover versus parallel designs: dose-escalation design comparisons for first-in-human studies.

    Science.gov (United States)

    Yan, Zhiwu; Hosmane, Balakrishna; Locke, Charles

    2013-01-01

    We study the statistical efficiency for rising-dose designs in the context of first-in-human studies. Specifically, we identify a class of crossover designs that are appealing in terms of both subject safety and statistical efficiency and, for a three-period, two-panel design in such a class, we compare its A-efficiency relative to the corresponding parallel designs and optimal/efficient crossover designs, respectively, under various plausible models. In the meantime, we also evaluate the impact of inclusion of baseline measurements as a covariate in the statistical analysis, for both crossover and parallel studies.

  13. Surgical planning and microvascular reconstruction of the mandible with a fibular flap using computer-aided design, rapid prototype modelling, and precontoured titanium reconstruction plates: a prospective study.

    Science.gov (United States)

    Sieira Gil, R; Roig, A Marí; Obispo, C Arranz; Morla, A; Pagès, C Martí; Perez, J Llopis

    2015-01-01

    The standard of mandibular reconstruction has increased since the introduction of computer-assisted design (CAD) and rapid prototype modelling (RPM) for surgical planning. Between 2008 and 2013, a prospective pilot study of 20 patients was planned to compare the outcomes of patients treated by mandibular reconstruction who had CAD and RPM-guided operations using a precontoured titanium plate, with the outcomes of patients treated conventionally. We recorded the time taken for reconstruction, total operating time, and whether this type of planning could improve the results of mandibular reconstruction. We found significant differences in the incidence of dental malocclusion (p=0.03) and exposure of the titanium plate (p=0.009). The mean operating time for reconstruction in the preoperative planning group was 135 (37)min compared with 176 (58)min in the conventional group (p=0.04). Preoperative planning using CAD and RPM can increase the accuracy of microvascular mandibular reconstruction and reduce the operating time for reconstruction. Copyright © 2014 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  14. Pulsed DEMO design assessment studies

    CERN Document Server

    Todd, T N

    2013-01-01

    Now that ITER is under construction, interest is increasing in the specification and design of the successor machine, a Demonstration Power Plant (DEMO), which in Europe is coordinated by the EFDA Power Plant Physics and Technology programme. This paper summarises the work carried out for EFDA in 2011-2012 on design issues pertinent to a pulsed version of DEMO, intended to be implemented with little or no extrapolation of technology available today. The work was carried out by the Euratom Fusion Associations CCFE, CEA, CRPP, ENEA and KIT, and in addition to a review of recent relevant literature addressed systems code analyses (pulse length vs. size), erosion of plasma facing components, thermomechanical fatigue in the blanket and first wall, a range of energy storage issues, and fatigue life improvements in Nb3Sn CICC superconductors.

  15. Report: Optimization study of the preparation factors for argan oil microcapsule based on hybrid-level orthogonal array design via SPSS modeling.

    Science.gov (United States)

    Zhao, Xi; Wu, Xiaoli; Zhou, Hui; Jiang, Tao; Chen, Chun; Liu, Mingshi; Jin, Yuanbao; Yang, Dongsheng

    2014-11-01

    To optimize the preparation factors for argan oil microcapsule using complex coacervation of chitosan cross-linked with gelatin based on hybrid-level orthogonal array design via SPSS modeling. Eight relatively significant factors were firstly investigated and selected as calculative factors for the orthogonal array design from the total of ten factors effecting the preparation of argan oil microcapsule by utilizing the single factor variable method. The modeling of hybrid-level orthogonal array design was built in these eight factors with the relevant levels (9, 9, 9, 9, 7, 6, 2 and 2 respectively). The preparation factors for argan oil microcapsule were investigated and optimized according to the results of hybrid-level orthogonal array design. The priorities order and relevant optimum levels of preparation factors standard to base on the percentage of microcapsule with the diameter of 30~40 μm via SPSS. Experimental data showed that the optimum factors were controlling the chitosan/gelatin ratio, the systemic concentration and the core/shell ratio at 1:2, 1.5% and 1:7 respectively, presetting complex coacervation pH at 6.4, setting cross-linking time and complex coacervation at 75 min and 30 min, using the glucose-delta lactone as the type of cross-linking agent, and selecting chitosan with the molecular weight of 2000~3000.

  16. Rainwater harvesting: model-based design evaluation.

    Science.gov (United States)

    Ward, S; Memon, F A; Butler, D

    2010-01-01

    The rate of uptake of rainwater harvesting (RWH) in the UK has been slow to date, but is expected to gain momentum in the near future. The designs of two different new-build rainwater harvesting systems, based on simple methods, are evaluated using three different design methods, including a continuous simulation modelling approach. The RWH systems are shown to fulfill 36% and 46% of WC demand. Financial analyses reveal that RWH systems within large commercial buildings maybe more financially viable than smaller domestic systems. It is identified that design methods based on simple approaches generate tank sizes substantially larger than the continuous simulation. Comparison of the actual tank sizes and those calculated using continuous simulation established that the tanks installed are oversized for their associated demand level and catchment size. Oversizing tanks can lead to excessive system capital costs, which currently hinders the uptake of systems. Furthermore, it is demonstrated that the catchment area size is often overlooked when designing UK-based RWH systems. With respect to these findings, a recommendation for a transition from the use of simple tools to continuous simulation models is made.

  17. Human visual performance model for crewstation design

    Science.gov (United States)

    Larimer, James; Prevost, Michael; Arditi, Aries; Azueta, Steven; Bergen, James; Lubin, Jeffrey

    1991-01-01

    An account is given of a Visibility Modeling Tool (VMT) which furnishes a crew-station designer with the means to assess configurational tradeoffs, with a view to the impact of various options on the unambiguous access of information to the pilot. The interactive interface of the VMT allows the manipulation of cockpit geometry, ambient lighting, pilot ergonomics, and the displayed symbology. Performance data can be displayed in the form of 3D contours into the crewstation graphic model, thereby yielding an indication of the operator's visual capabilities.

  18. Application of quality by design concept to develop a dual gradient elution stability-indicating method for cloxacillin forced degradation studies using combined mixture-process variable models.

    Science.gov (United States)

    Zhang, Xia; Hu, Changqin

    2017-09-08

    Penicillins are typical of complex ionic samples which likely contain large number of degradation-related impurities (DRIs) with different polarities and charge properties. It is often a challenge to develop selective and robust high performance liquid chromatography (HPLC) methods for the efficient separation of all DRIs. In this study, an analytical quality by design (AQbD) approach was proposed for stability-indicating method development of cloxacillin. The structures, retention and UV characteristics rules of penicillins and their impurities were summarized and served as useful prior knowledge. Through quality risk assessment and screen design, 3 critical process parameters (CPPs) were defined, including 2 mixture variables (MVs) and 1 process variable (PV). A combined mixture-process variable (MPV) design was conducted to evaluate the 3 CPPs simultaneously and a response surface methodology (RSM) was used to achieve the optimal experiment parameters. A dual gradient elution was performed to change buffer pH, mobile-phase type and strength simultaneously. The design spaces (DSs) was evaluated using Monte Carlo simulation to give their possibility of meeting the specifications of CQAs. A Plackett-Burman design was performed to test the robustness around the working points and to decide the normal operating ranges (NORs). Finally, validation was performed following International Conference on Harmonisation (ICH) guidelines. To our knowledge, this is the first study of using MPV design and dual gradient elution to develop HPLC methods and improve separations for complex ionic samples. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Models of Design: Envisioning a Future Design Education

    Science.gov (United States)

    Friedman, Ken

    2012-01-01

    This article offers a large-scale view of how design fits in the world economy today, and the role of design education in preparing designers for their economic and professional role. The current context of design involves broad-based historical changes including a major redistribution of geopolitical and industrial power from the West to the…

  20. Towards a formal design model based on a genetic design model system

    DEFF Research Database (Denmark)

    Storga, Mario; Andreasen, Mogens Myrup; Marjanovic, Dorian

    2005-01-01

    The research presented in this article is aimed to the investigation of the nature, building and practical role of a Design Ontology as a potential framework for the more efficient product development data-, information- and knowledge- description, -explanation, -understanding and -reusing...... by IEEE, provides us definitions for the most general and universal concepts, that we used in our research for derivation of terms definitions and axioms in the Design Ontology. The Design Ontology was evaluated using the OntoEdit® ontology engineering environment, on a real product example, and based....... In this article, we briefly summarize our experience of converting informal definitions of the concepts from the product development domain based on the existing theoretical background into formal design model. As a main data source for extracting the content of a design ontology, Genetic Design Model System...

  1. Towards a formal design model based on a genetic design model system

    DEFF Research Database (Denmark)

    Storga, Mario; Andreasen, Mogens Myrup; Marjanovic, Dorian

    2005-01-01

    . In this article, we briefly summarize our experience of converting informal definitions of the concepts from the product development domain based on the existing theoretical background into formal design model. As a main data source for extracting the content of a design ontology, Genetic Design Model System......The research presented in this article is aimed to the investigation of the nature, building and practical role of a Design Ontology as a potential framework for the more efficient product development data-, information- and knowledge- description, -explanation, -understanding and -reusing...... by IEEE, provides us definitions for the most general and universal concepts, that we used in our research for derivation of terms definitions and axioms in the Design Ontology. The Design Ontology was evaluated using the OntoEdit® ontology engineering environment, on a real product example, and based...

  2. Use of Two-Part Regression Calibration Model to Correct for Measurement Error in Episodically Consumed Foods in a Single-Replicate Study Design: EPIC Case Study

    NARCIS (Netherlands)

    Agogo, G.O.; Voet, van der H.; Veer, van 't P.; Ferrari, P.; Leenders, M.; Muller, D.C.; Sánchez-Cantalejo, E.; Bamia, C.; Braaten, T.; Knüppel, S.; Johansson, I.; Eeuwijk, van F.A.; Boshuizen, H.C.

    2014-01-01

    In epidemiologic studies, measurement error in dietary variables often attenuates association between dietary intake and disease occurrence. To adjust for the attenuation caused by error in dietary intake, regression calibration is commonly used. To apply regression calibration, unbiased reference m

  3. Use of Two-Part Regression Calibration Model to Correct for Measurement Error in Episodically Consumed Foods in a Single-Replicate Study Design : EPIC Case Study

    NARCIS (Netherlands)

    Agogo, George O; der Voet, Hilko van; Veer, Pieter Van't; Ferrari, Pietro; Leenders, Max; Muller, David C; Sánchez-Cantalejo, Emilio; Bamia, Christina; Braaten, Tonje; Knüppel, Sven; Johansson, Ingegerd; van Eeuwijk, Fred A; Boshuizen, Hendriek

    2014-01-01

    In epidemiologic studies, measurement error in dietary variables often attenuates association between dietary intake and disease occurrence. To adjust for the attenuation caused by error in dietary intake, regression calibration is commonly used. To apply regression calibration, unbiased reference m

  4. Game Factors and Game-Based Learning Design Model

    Directory of Open Access Journals (Sweden)

    Yen-Ru Shi

    2015-01-01

    Full Text Available How to design useful digital game-based learning is a topic worthy of discussion. Past research focused on specific game genres design, but it is difficult to use when the target game genre differs from the default genres used in the research. This study presents macrodesign concepts that elucidates 11 crucial game-design factors, including game goals, game mechanism, game fantasy, game value, interaction, freedom, narrative, sensation, challenges, sociality, and mystery. We clearly define each factor and analyze the relationships among the 11 factors to construct a game-based learning design model. Two application examples are analyzed to verify the usability of the model and the performance of these factors. It can assist educational game designers in developing interesting games.

  5. Latent spatial models and sampling design for landscape genetics

    Science.gov (United States)

    Hanks, Ephraim M.; Hooten, Mevin B.; Knick, Steven T.; Oyler-McCance, Sara J.; Fike, Jennifer A.; Cross, Todd B.; Schwartz, Michael K.

    2016-01-01

    We propose a spatially-explicit approach for modeling genetic variation across space and illustrate how this approach can be used to optimize spatial prediction and sampling design for landscape genetic data. We propose a multinomial data model for categorical microsatellite allele data commonly used in landscape genetic studies, and introduce a latent spatial random effect to allow for spatial correlation between genetic observations. We illustrate how modern dimension reduction approaches to spatial statistics can allow for efficient computation in landscape genetic statistical models covering large spatial domains. We apply our approach to propose a retrospective spatial sampling design for greater sage-grouse (Centrocercus urophasianus) population genetics in the western United States.

  6. Selecting the appropriate study design for your research: Descriptive study designs

    OpenAIRE

    Aamir Omair

    2015-01-01

    This article describes the importance of selecting the appropriate epidemiological study design for a given study question. It provides an explanation to the different terms used in describing study designs with regards to observational versus interventional and descriptive versus analytical types of study designs. This article focuses on the description of the different types of descriptive study designs, that is, case report, case series, correlational, and cross-sectional study designs. Th...

  7. Models and design principles for teacher research

    NARCIS (Netherlands)

    Admiraal, Wilfried; Smit, Ben; Zwart, Rosanne|info:eu-repo/dai/nl/298981823

    2014-01-01

    Teacher research is a way to bridge the gap between theory and teaching practice. Various types of teacher research can be distinguished, including most commonly: action research, selfstudy, lesson study, design-based research, and scholarship of teaching and learning. All types of teacher research

  8. Models and design principles for teacher research

    NARCIS (Netherlands)

    Admiraal, Wilfried; Smit, Ben; Zwart, Rosanne

    2014-01-01

    Teacher research is a way to bridge the gap between theory and teaching practice. Various types of teacher research can be distinguished, including most commonly: action research, selfstudy, lesson study, design-based research, and scholarship of teaching and learning. All types of teacher research

  9. The Effects of Model Making on Design and Learning in Landscape Architecture Education

    Science.gov (United States)

    Duzenli, Tugba; Yilmaz, Serap; Alpak, Elif Merve

    2017-01-01

    Purpose: One of the modeling methods used in the training of all design disciplines is physical model making. This study investigates the model-making technique and emphasizes the positive effects of model-making and its utility in the academic setting in order to understand its effects on design and learning. The "Equipment Design"…

  10. MODELING AND ROBUST DESIGN OF REMANUFACTURING LOGISTICS NETWORKS BASED ON DESIGN OF EXPERIMENT

    Institute of Scientific and Technical Information of China (English)

    Xia Shouchang; Xi Lifeng; Hu Zongwu

    2004-01-01

    The uncertainty of time, quantity and quality of recycling products leads to the bad stability and flexibility of remanufacturing logistics networks, and general design only covered the minimizing logistics cost, thus, robust design is presented here to solve the uncertainty. The mathematical model of remanufacturing logistics networks is built based on stochastic distribution of uncontrollable factors, and robust objectives are presented. The integration of mathematical simulation and design of experiment method is performed to do sensitive analysis. The influence of each factor and level on the system is investigated, and the main factors and optimum combination are studied. The numbers of factors, level of each factor and design process of experiment are investigated as well. Finally, the process of robust design based on design of experiment is demonstrated by a detailed example.

  11. Designing and Explaining the Model of Persistent Customer Loyalty in e-Commerce: A Study in the e-Retailer’s Web Sites

    National Research Council Canada - National Science Library

    Mohammadreza Hamidizadeh; Abasali Hajkarimi; Mohammad Javad Naeiji

    2011-01-01

    ... commerce especially in an e-retailing context have not been addressed. Therefore, the aim of this study is to develop and validate such antecedents of persistent loyalty and to propose a comprehensive model...

  12. Designing and Explaining the Model of Persistent Customer Loyalty in e-Commerce: A Study in the e-Retailer’s Web Sites

    National Research Council Canada - National Science Library

    mohammad reza hamidizadeh; abbasali hajkarimi; mohammad javad naeiji

    2011-01-01

    ... in electronic commerce especially in an e-retailing context have not been addressed. Therefore, the aim of this study is to develop and validate such antecedents of persistent loyalty and to propose a comprehensive model...

  13. Persuasive Game Design: A model and its definitions

    NARCIS (Netherlands)

    Visch, V.T.; Vegt, N.J.H.; Anderiesen, H.; Van der Kooij, K.

    2013-01-01

    The following position paper proposes a general theoretical model for persuasive game design. This model combines existing theories on persuasive technology, serious gaming, and gamification. The model is based on user experience, gamification design, and transfer effects.

  14. Persuasive Game Design: A model and its definitions

    NARCIS (Netherlands)

    Visch, V.T.; Vegt, N.J.H.; Anderiesen, H.; Van der Kooij, K.

    2013-01-01

    The following position paper proposes a general theoretical model for persuasive game design. This model combines existing theories on persuasive technology, serious gaming, and gamification. The model is based on user experience, gamification design, and transfer effects.

  15. 智能化安全服装的设计模式探讨%A Study on Designing Models of Smart Safety Clothing

    Institute of Scientific and Technical Information of China (English)

    贺义军; 洪文进; 唐颖; 薛哲彬

    2016-01-01

    Based on discussing the special features of smart clothing design and the incompetence of traditional clothing design theory in smart safety clothing design, the paper worked out a basic framework of smart and safety clothing design model from the inspiration of interactive application. It holds that it is necessary to establish a relatively complete designing system that integrates with user’s emotional experience, interactive experience and situation experience by taking overall consideration of all key design points, including the positioning of the smart safety clothing, user’s experience on the clothing, design strategy, design mode, etc.%文章基于服装智能设计的特殊性与传统服装设计理论不适应于智能化安全服装设计的情况,进行相关探索,从交互应用获得启示,初步形成智能化安全服装设计模式基本框架。认为应基于智能化安全服装设计定位,对各设计要点进行统筹,从服装产品体验、设计策略、设计模式的思考为出发点,形成一条集用户情感体验、互动体验、情景体验为一体且相对完整的设计体系。智能化安全服装设计模式是关于智能化安全服装设计方法的思考,是对现阶段纺织服装产业创新升级的一次探索,使产业在开展具体智能化产品设计时找到可借鉴的方法。

  16. Risk Classification Model for Design and Build Projects

    Directory of Open Access Journals (Sweden)

    O. E. Ogunsanmi

    2011-07-01

    Full Text Available The purpose of this paper is to investigate if the various risk sources in Design and Build projects can be classified into three risk groups of cost, time and quality using the discriminant analysis technique. Literature search was undertaken to review issues of risk sources, classification of the identified risks into a risk structure, management of risks and effects of risks all on Design and Build projects as well as concepts of discriminant analysis as a statistical technique. This literature review was undertaken through the use of internet, published papers, journal articles and other published reports on risks in Design and Build projects. A research questionnaire was further designed to collect research information. This research study is a survey research that utilized cross-sectional design to capture the primary data. The data for the survey was collected in Nigeria. In all 40 questionnaires were sent to various respondents that included Architects, Engineers, Quantity Surveyors and Builders who had used Design and Build procurement method for their recently completed projects. Responses from these retrieved questionnaires that measured the impact of risks on Design and Build were analyzed using the discriminant analysis technique through the use of SPSS software package to build two discriminant models for classifying risks into cost, time and quality risk groups. Results of the study indicate that time overrun and poor quality are the two factors that discriminate between cost, time and quality related risk groups. These two discriminant functions explain the variation between the risk groups. All the discriminating variables of cost overrun, time overrun and poor quality demonstrate some relationships with the two discriminant functions. The two discriminant models built can classify risks in Design and Build projects into risk groups of cost, time and quality. These classifications models have 72% success rate of classification

  17. Spiral 2: preliminary design study

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-11-15

    The scientific council of GANIL asked to perform a comparative study on the production methods based on gamma induced fission and rapid-neutron induced fission concerning the nature and the intensity of the neutron-rich products. The production rate expected should be around 10{sup 13} fissions per second. The study should include the implantation and the costs of the concerned accelerators. The scientific committee recommended also to study the possibility to re-inject the radioactive beams of SPIRAL-II in the cyclotrons available at GANIL in order to give access to an energy range from 1.7 to 100 MeV/nucleon. For that purpose, some study groups have been formed to evaluate the possibility of such a project in the different components: physics case, target-ion sources, drivers, post-acceleration and general infrastructure. The organization of the project study is given at the end of this report. The following report presents an overview of the study. Particularly the total costs have been assessed according to 3 options for the driver: 38.0*10{sup 6} euros for a 40 MeV deuteron linac, 18.7*10{sup 6} euros for a 45 MeV electron linac, and 29.1*10{sup 6} euros for a 80 MeV deuteron cyclotron.

  18. Error Modeling and Design Optimization of Parallel Manipulators

    DEFF Research Database (Denmark)

    Wu, Guanglei

    challenges due to their highly nonlinear behaviors, thus, the parameter and performance analysis, especially the accuracy and stiness, are particularly important. Toward the requirements of robotic technology such as light weight, compactness, high accuracy and low energy consumption, utilizing optimization...... technique in the design procedure is a suitable approach to handle these complex tasks. As there is no unied design guideline for the parallel manipulators, the study described in this thesis aims to provide a systematic analysis for this type of mechanisms in the early design stage, focusing on accuracy...... analysis and design optimization. The proposed approach is illustrated with the planar and spherical parallel manipulators. The geometric design, kinematic and dynamic analysis, kinetostatic modeling and stiness analysis are also presented. Firstly, the study on the geometric architecture and kinematic...

  19. Collective design in 3D printing: A large scale empirical study of designs, designers and evolution

    DEFF Research Database (Denmark)

    Özkil, Ali Gürcan

    2017-01-01

    This paper provides an empirical study of a collective design platform (Thingiverse); with the aim of understanding the phenomenon and investigating how designs concurrently evolve through the large and complex network of designers. The case study is based on the meta-data collected from 158 489 ...

  20. Interval Management Display Design Study

    Science.gov (United States)

    Baxley, Brian T.; Beyer, Timothy M.; Cooke, Stuart D.; Grant, Karlus A.

    2014-01-01

    In 2012, the Federal Aviation Administration (FAA) estimated that U.S. commercial air carriers moved 736.7 million passengers over 822.3 billion revenue-passenger miles. The FAA also forecasts, in that same report, an average annual increase in passenger traffic of 2.2 percent per year for the next 20 years, which approximates to one-and-a-half times the number of today's aircraft operations and passengers by the year 2033. If airspace capacity and throughput remain unchanged, then flight delays will increase, particularly at those airports already operating near or at capacity. Therefore it is critical to create new and improved technologies, communications, and procedures to be used by air traffic controllers and pilots. National Aeronautics and Space Administration (NASA), the FAA, and the aviation industry are working together to improve the efficiency of the National Airspace System and the cost to operate in it in several ways, one of which is through the creation of the Next Generation Air Transportation System (NextGen). NextGen is intended to provide airspace users with more precise information about traffic, routing, and weather, as well as improve the control mechanisms within the air traffic system. NASA's Air Traffic Management Technology Demonstration-1 (ATD-1) Project is designed to contribute to the goals of NextGen, and accomplishes this by integrating three NASA technologies to enable fuel-efficient arrival operations into high-density airports. The three NASA technologies and procedures combined in the ATD-1 concept are advanced arrival scheduling, controller decision support tools, and aircraft avionics to enable multiple time deconflicted and fuel efficient arrival streams in high-density terminal airspace.

  1. Statistical Design Model (SDM) of satellite thermal control subsystem

    Science.gov (United States)

    Mirshams, Mehran; Zabihian, Ehsan; Aarabi Chamalishahi, Mahdi

    2016-07-01

    Satellites thermal control, is a satellite subsystem that its main task is keeping the satellite components at its own survival and activity temperatures. Ability of satellite thermal control plays a key role in satisfying satellite's operational requirements and designing this subsystem is a part of satellite design. In the other hand due to the lack of information provided by companies and designers still doesn't have a specific design process while it is one of the fundamental subsystems. The aim of this paper, is to identify and extract statistical design models of spacecraft thermal control subsystem by using SDM design method. This method analyses statistical data with a particular procedure. To implement SDM method, a complete database is required. Therefore, we first collect spacecraft data and create a database, and then we extract statistical graphs using Microsoft Excel, from which we further extract mathematical models. Inputs parameters of the method are mass, mission, and life time of the satellite. For this purpose at first thermal control subsystem has been introduced and hardware using in the this subsystem and its variants has been investigated. In the next part different statistical models has been mentioned and a brief compare will be between them. Finally, this paper particular statistical model is extracted from collected statistical data. Process of testing the accuracy and verifying the method use a case study. Which by the comparisons between the specifications of thermal control subsystem of a fabricated satellite and the analyses results, the methodology in this paper was proved to be effective. Key Words: Thermal control subsystem design, Statistical design model (SDM), Satellite conceptual design, Thermal hardware

  2. Automating Risk Analysis of Software Design Models

    Directory of Open Access Journals (Sweden)

    Maxime Frydman

    2014-01-01

    Full Text Available The growth of the internet and networked systems has exposed software to an increased amount of security threats. One of the responses from software developers to these threats is the introduction of security activities in the software development lifecycle. This paper describes an approach to reduce the need for costly human expertise to perform risk analysis in software, which is common in secure development methodologies, by automating threat modeling. Reducing the dependency on security experts aims at reducing the cost of secure development by allowing non-security-aware developers to apply secure development with little to no additional cost, making secure development more accessible. To automate threat modeling two data structures are introduced, identification trees and mitigation trees, to identify threats in software designs and advise mitigation techniques, while taking into account specification requirements and cost concerns. These are the components of our model for automated threat modeling, AutSEC. We validated AutSEC by implementing it in a tool based on data flow diagrams, from the Microsoft security development methodology, and applying it to VOMS, a grid middleware component, to evaluate our model's performance.

  3. Planetary Suit Hip Bearing Model for Predicting Design vs. Performance

    Science.gov (United States)

    Cowley, Matthew S.; Margerum, Sarah; Harvil, Lauren; Rajulu, Sudhakar

    2011-01-01

    Designing a planetary suit is very complex and often requires difficult trade-offs between performance, cost, mass, and system complexity. In order to verifying that new suit designs meet requirements, full prototypes must eventually be built and tested with human subjects. Using computer models early in the design phase of new hardware development can be advantageous, allowing virtual prototyping to take place. Having easily modifiable models of the suit hard sections may reduce the time it takes to make changes to the hardware designs and then to understand their impact on suit and human performance. A virtual design environment gives designers the ability to think outside the box and exhaust design possibilities before building and testing physical prototypes with human subjects. Reductions in prototyping and testing may eventually reduce development costs. This study is an attempt to develop computer models of the hard components of the suit with known physical characteristics, supplemented with human subject performance data. Objectives: The primary objective was to develop an articulating solid model of the Mark III hip bearings to be used for evaluating suit design performance of the hip joint. Methods: Solid models of a planetary prototype (Mark III) suit s hip bearings and brief section were reverse-engineered from the prototype. The performance of the models was then compared by evaluating the mobility performance differences between the nominal hardware configuration and hardware modifications. This was accomplished by gathering data from specific suited tasks. Subjects performed maximum flexion and abduction tasks while in a nominal suit bearing configuration and in three off-nominal configurations. Performance data for the hip were recorded using state-of-the-art motion capture technology. Results: The results demonstrate that solid models of planetary suit hard segments for use as a performance design tool is feasible. From a general trend perspective

  4. Designing in an Interplay with a Product Model - Explained by Design Units

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik; Andreasen, Mogens Myrup

    1996-01-01

    If we expand the concept of product models from a bill of material and representations of parts to a genetic model (a chromosome), which is able to capture decisions on functions and design concepts during the design activity, a new design situation is created. This paper treats designing...... in an interplay with a product model in a so-called Designer's Workbench, based on the clarification of the structuring of the product model, the design operationswhich succesively build up the product model, and the role of the product model in the design work as basis for synthesis and modelling of properties....... The main results from this paper are identification of the classes of product models in a Designer's Workbench and description of a scenario for designing in an interplay with the product models....

  5. TLEP design study forges ahead

    CERN Multimedia

    Alain Blondel & Mike Koratzinos

    2013-01-01

    As the Future Circular Collider (FCC) study is launched, one of its component parts, TLEP, enjoys a successful workshop at CERN. The FCC study looks at all options for a future circular collider with the emphasis on a hadron machine with TLEP as a possible intermediate step.   The poster of the sixth TLEP workshop that took place at CERN. Japanese artist Kazuya Akimoto kindly agreed to the use of one of his works as the basis for the poster’s backdrop. October 16 to 18 saw a three-day workshop on TLEP, the sixth in the series. The workshop took place at CERN and was well attended, informative and stimulating. To name just one of the influential people present, Herwig Schopper, ex-Director General of CERN and instrumental in the approval, construction and success of LEP, was among the participants. But what exactly is TLEP? The name was, somehow serendipitously, coined from future lepton collider option studies and stands for triple-LEP, a machine three times the size of LEP. But th...

  6. Principles of study design in environmental epidemiology.

    OpenAIRE

    Morgenstern, H.; Thomas, D

    1993-01-01

    This paper discusses the principles of study design and related methodologic issues in environmental epidemiology. Emphasis is given to studies aimed at evaluating causal hypotheses regarding exposures to suspected health hazards. Following background sections on the quantitative objectives and methods of population-based research, we present the major types of observational designs used in environmental epidemiology: first, the three basic designs involving the individual as the unit of anal...

  7. Mobile Variable Depth Sampling System Design Study

    Energy Technology Data Exchange (ETDEWEB)

    BOGER, R.M.

    2000-08-25

    A design study is presented for a mobile, variable depth sampling system (MVDSS) that will support the treatment and immobilization of Hanford LAW and HLW. The sampler can be deployed in a 4-inch tank riser and has a design that is based on requirements identified in the Level 2 Specification (latest revision). The waste feed sequence for the MVDSS is based on Phase 1, Case 3S6 waste feed sequence. Technical information is also presented that supports the design study.

  8. Modelling, design, and optimization of net-zero energy buildings

    CERN Document Server

    Athienitis, Andreas

    2015-01-01

    Building energy design is currently going through a period of major changes. One key factor of this is the adoption of net-zero energy as a long term goal for new buildings in most developed countries. To achieve this goal a lot of research is needed to accumulate knowledge and to utilize it in practical applications. In this book, accomplished international experts present advanced modeling techniques as well as in-depth case studies in order to aid designers in optimally using simulation tools for net-zero energy building design. The strategies and technologies discussed in this book are, ho

  9. FUZZY OPTIMIZATION MODEL OF MAINTENANCE DESIGN FOR PRODUCT LEVEL REUSE

    Institute of Scientific and Technical Information of China (English)

    Feng Zhen; Xu Guohua

    2004-01-01

    Most used products must be maintained before they are reused.The modeling method for maintenance design of product level reuse based on quality function deployment is presented.A fuzzy linear optimization model is developed under financial uncertainty.Objective of the model is to maximize improvement rate of customer satisfaction level.Maintenance cost constrain is fuzzy.The algorithm for solution to the model is given.Its optimized results not only give attention to satisfaction degree of cost constraint,but also maximize objective value.An illustrative example involved water bump reuse is studied and the results show that the proposed model can effectively help maintenance planner determine the better design scheme.

  10. Multi-Imagery Exploitation Configuration Design Study.

    Science.gov (United States)

    1982-11-01

    A124 88? MULTI-IMAGERY ENPLOITRTION CONFIGURATION DESIGN STUDY 1/2 (U) HARRIS CORP MEL8OURNE FL GOVERNMENT COMMUNICATION SYSTEMS DIV T E TIMOTHY ET...DESIGN STUDY 212 (U) HARRIS CORP MELBOURNE FL GOVERNMENT COMMUNICATION SYSTEMS DIV T E TIMOTHY ET AL. NOV 82 RRDC-TR-82-33 UNCLASSIFIED F31692-Si-C-8095 F

  11. On the design of satisfaction studies

    DEFF Research Database (Denmark)

    Kristensen, Kai; Eskildsen, Jacob Kjær

    2008-01-01

    In the effect sampling method, presentation of researcher, the intro text, the order of questions in the questionnaire along with the number of categories in the rating scale is tested in relation to the design of satisfaction studies. Based on the analyses specific recommendations for designing...... satisfaction studies are given....

  12. Design study for asteroidal exploitation

    Science.gov (United States)

    Adams, Carl; Blissit, Jim; Jarrett, Dave; Sanner, Rob; Yanagawa, Koji

    1985-08-01

    A systematic approach to asteroidal exploitation for the 1990 to 2010 time frame is presented as an initial step toward expanding the use of space beyond the space station by providing a source of lower cost materials. With only a limited amount of information known about the asteroids, reconnaissance and exploration phases to determine the exact locations and compositions of several earth-approaching asteroids are required. Earth-based telescopes are used to locate and study the asteroids, while unmanned probes will return samples of asteroidal material to earth for analysis. After these phases are completed, the retrieval of a 35,000 metric ton piece of the asteroid Anteros is undertaken. A cargo transporter uses magnetoplasmadynamic (MPD) arcjets outbound and a mass-driver using asteroidal material inbound. A crew ship uses ion engines. Low thrust trajectories are used for both spacecraft. A materials processing facility will manufacture propellant pellets and retrieve non-propellant materials for spacecraft use. The cost is 1/10th that to transport the same materials from earth to high earth orbit. The project will cost 25 percent less if done in conjunction with a lunar and Martian base.

  13. Study on the Model of the Elderly's Information Needs: Design and Application%老年人信息需求模型的构建与应用

    Institute of Scientific and Technical Information of China (English)

    左美云; 刘勍勍; 刘方

    2009-01-01

    With the increase of the number of the elderly, the Chinese society is gradually stepping into the aged society from the aging society. Both the aging society and the aged society will produce a far-reaching impact on the basic national policy, and generate a series of social problems and opportunities. As a typical category of users, the expansion size of the elderly will change the users' structure of IT/IS (Information Technology/ Information System) products significantly. This is not only a great challenge to the IT industry, but also a great opportunity. As scholars in IT/IS area, we should focus on the social hotspots and difficult issues as well as the future development trend, and aim at the development of IT/IS under the conditions of aging society and provide a theoretical framework. To be more specific, we need to deeply analyze the content of the elderly needs of the IT/IS, exam the features and affecting factors in the adoption and usage process of IT/IS products by elderly people, and design the IT/IS products specifically for the elderly. Based on the Maslow's theory of hierarchy of needs and literary study, this paper analyzes the needs of the elderly and designs a model of the elderly's information needs. Given the above analysis, we discuss the implications of applying the model. We point out the IT/IS products' positive roles in benefit to the elderly's information needs. On the other hand, we analyze the impact of aging society on the IT/IS products and reach the conclusion: with the three aspects of active works of developing and even creating the elderly's information needs, establishing information systems to cover the elderly users, and designing specifically the human-computer interface for the elderly users, we can deal with challenges brought by aging society and seize the potential industry opportunities.%随着老年人数量的日益增多,中国社会正逐渐由老龄化社会步入老龄社会.老龄化社会和老龄社会将对

  14. Electromagnetic sunscreen model: design of experiments on particle specifications.

    Science.gov (United States)

    Lécureux, Marie; Deumié, Carole; Enoch, Stefan; Sergent, Michelle

    2015-10-01

    We report a numerical study on sunscreen design and optimization. Thanks to the combined use of electromagnetic modeling and design of experiments, we are able to screen the most relevant parameters of mineral filters and to optimize sunscreens. Several electromagnetic modeling methods are used depending on the type of particles, density of particles, etc. Both the sun protection factor (SPF) and the UVB/UVA ratio are considered. We show that the design of experiments' model should include interactions between materials and other parameters. We conclude that the material of the particles is a key parameter for the SPF and the UVB/UVA ratio. Among the materials considered, none is optimal for both. The SPF is also highly dependent on the size of the particles.

  15. Statistical design and evaluation of biomarker studies.

    Science.gov (United States)

    Dobbin, Kevin K

    2014-01-01

    We review biostatistical aspects of biomarker studies, including design and analysis issues, covering the range of settings required for translational research-from early exploratory studies through clinical trials.

  16. OXYGEN PRESSURE REGULATOR DESIGN AND ANALYSIS THROUGH FINITE ELEMENT MODELING

    Directory of Open Access Journals (Sweden)

    Asterios KOSMARAS

    2017-05-01

    Full Text Available Oxygen production centers produce oxygen in high pressure that needs to be defused. A regulator is designed and analyzed in the current paper for medical use in oxygen production centers. This study aims to design a new oxygen pressure regulator and perform an analysis using Finite Element Modeling in order to evaluate its working principle. In the design procedure,the main elements and the operating principles of a pressure regulator are taking into account. The regulator is designed and simulations take place in order to assessthe proposed design. Stress analysis results are presented for the main body of the regulator, as well as, flow analysis to determine some important flow characteristics in the inlet and outlet of the regulator.

  17. Rethinking Design Process: Using 3D Digital Models as an Interface in Collaborative Session

    Science.gov (United States)

    Ding, Suining

    2008-01-01

    This paper describes a pilot study for an alternative design process by integrating a designer-user collaborative session with digital models. The collaborative session took place in a 3D AutoCAD class for a real world project. The 3D models served as an interface for designer-user collaboration during the design process. Students not only learned…

  18. Rethinking Design Process: Using 3D Digital Models as an Interface in Collaborative Session

    Science.gov (United States)

    Ding, Suining

    2008-01-01

    This paper describes a pilot study for an alternative design process by integrating a designer-user collaborative session with digital models. The collaborative session took place in a 3D AutoCAD class for a real world project. The 3D models served as an interface for designer-user collaboration during the design process. Students not only learned…

  19. Modeling Web-based Educational Systems: Process Design Teaching Model

    Directory of Open Access Journals (Sweden)

    Elena Rokou

    2004-01-01

    Full Text Available Using modeling languages is essential to the construction of educational systems based on software engineering principles and methods. Furthermore, the instructional design is undoubtedly the cornerstone of the design and development of educational systems. Although several methodologies and languages have been proposed for the specification of isolated educational multimedia systems, none has optimum results for the description of these systems and, especially, for their pedagogical aspect. Of course this is due primarily to how these systems function and are applied; it is not due to the language itself, although its special characteristics contribute substantially to the development of these systems sometimes positively and sometimes negatively. In this paper, we briefly describe the introduction of stereotypes to the pedagogical design of educational systems and appropriate modifications of the existing package diagrams of UML (Unified Modeling Language. The main objective of these new stereotypes is to describe sufficiently the mechanisms of generation, monitoring and re-adapting of teaching and student’s models which can be used in the educational applications.

  20. Thinking outside ISD: A management model for instructional design

    Science.gov (United States)

    Taylor, Tony Dewayne

    The purpose of this study was to examine the effectiveness of an instructional system management-level model proposed by the author designed to orchestrate the efficient development and implementation of customer requested curriculum. The three phases of systems-based model are designed to ensure delivery of high quality and timely instruction are: (1) the assessment and documentation of organizational training requirements; (2) project management control of curriculum development; and (3) the implementation of relevant instruction by competent instructors. This model also provides (4) measurable and quantifiable course evaluation results to justify return on investment and validate its importance with respect to the customer's organizational strategic objectives. The theoretical approach for this study was systems theory-based due to the nature of the instructional systems design model and the systematic design of the management model. The study was accomplished using single-case study application of qualitative style of inquiry as described by Patton (2002). Qualitative inquiry was selected to collect and analyze participant holistic perspective assessment of effectiveness, relevance, and timeliness of the instructional design management model. Participants for this study included five managers, five subject matter experts, and six students assigned to a military organization responsible for the collection of hydrographic data for the U.S. Navy. Triangulation of data sources within the qualitative framework of the study incorporated the three participant groups---managers, SMEs, and students---incorporated multiple views of the course development and implementation to validate the findings and the remove researcher bias. Qualitative coding was accomplished by importing transcribed interviews into Microsoft Excel and sorted using Auto-Filter. The coded interviews indicated effective functionality in the views of the model from each of the three participant groups

  1. Design models for anticipating future usage

    NARCIS (Netherlands)

    Rooden, M.J.

    2001-01-01

    In usage centred design designers need to consider a variety of users operating the intended product in a variety of ways in a variety of contexts. By tuning their design to potential ways of operation designers can prevent usability problems from occurring. In the project it was explored how design

  2. A Model of Framing in Design Teams

    Science.gov (United States)

    Zahedi, Mithra; Heaton, Lorna

    2017-01-01

    How do ideas evolve in the context of collaborative design? This research explores the framing strategies and tools involved in the co-construction of a shared understanding in the early stages of a design project. We observed a team of four industrial design students working to design a pop-up shop. We found that, while the key design elements of…

  3. Humus and humility in ecosystem model design

    Science.gov (United States)

    Rowe, Ed

    2015-04-01

    that are developed in collaboration with stakeholders are much more likely to be used (Sterk et al., 2012). Rather than trying to re-frame the question to suit the model, modellers need the humility to accept that the model is inappropriate and should develop the capacity to model the question. In this study these issues are explored using the MADOC model (Rowe et al., 2014) as an example. MADOC was developed by integrating existing models of humus development, acid-base exchange, and organic matter dissolution to answer a particular policy question: how do acidifying pollutants affect pH in humic soils? Including the negative feedback whereby an increase in pH reduces the solubility of organic acids improved the predictive accuracy for pH and dissolved organic carbon flux in the peats and organomineral soils that are widespread in upland Britain. The model has been used to generate the UK response to data requests under the UN Convention on Long-Range Transboundary Air Pollution. References: Funtowicz, S.O. & Ravetz, J.R., 1990. Uncertainty and Quality in Science for Policy. Kluwer. Rowe, E.C., et al. 2014. Environmental Pollution 184, 271-282. Sterk, B., et al. 2012. Environmental Modelling & Software 26, 310-316.

  4. Application of Absorption Modeling in Rational Design of Drug Product Under Quality-by-Design Paradigm.

    Science.gov (United States)

    Kesisoglou, Filippos; Mitra, Amitava

    2015-09-01

    Physiologically based absorption models can be an important tool in understanding product performance and hence implementation of Quality by Design (QbD) in drug product development. In this report, we show several case studies to demonstrate the potential application of absorption modeling in rational design of drug product under the QbD paradigm. The examples include application of absorption modeling—(1) prior to first-in-human studies to guide development of a formulation with minimal sensitivity to higher gastric pH and hence reduced interaction when co-administered with PPIs and/or H2RAs, (2) design of a controlled release formulation with optimal release rate to meet trough plasma concentrations and enable QD dosing, (3) understanding the impact of API particle size distribution on tablet bioavailability and guide formulation design in late-stage development, (4) assess impact of API phase change on product performance to guide specification setting, and (5) investigate the effect of dissolution rate changes on formulation bioperformance and enable appropriate specification setting. These case studies are meant to highlight the utility of physiologically based absorption modeling in gaining a thorough understanding of the product performance and the critical factors impacting performance to drive design of a robust drug product that would deliver the optimal benefit to the patients.

  5. Designing A Framework To Design A Business Model For The 'Bottom Of The Pyramid' Population

    Directory of Open Access Journals (Sweden)

    Ver Loren van Themaat, Tanye

    2013-11-01

    Full Text Available This article presents a framework for developing and designing a business model to target the bottom of the pyramid (BoP population. Using blue ocean strategy and business model literature, integrated with research on the BoP, the framework offers a systematic approach for organisations to analyse and understand all aspects of the BoP and their environment, and then design a business model that minimises the risk of failure and fulfils the core requirements of the BoP. A case study on Capitec Bank demonstrates how the framework can be applied to the real world. The case study shows the practical examples that Capitec uses to target the BoP successfully, and the logic behind these actions. Further validation was done through interviews with experts in the relevant fields used in this study.

  6. Fusion reactor blanket/shield design study

    Energy Technology Data Exchange (ETDEWEB)

    Smith, D.L.; Clemmer, R.G.; Harkness, S.D.

    1979-07-01

    A joint study of tokamak reactor first-wall/blanket/shield technology was conducted by Argonne National Laboratory (ANL) and McDonnell Douglas Astronautics Company (MDAC). The objectives of this program were the identification of key technological limitations for various tritium-breeding-blanket design concepts, establishment of a basis for assessment and comparison of the design features of each concept, and development of optimized blanket designs. The approach used involved a review of previously proposed blanket designs, analysis of critical technological problems and design features associated with each of the blanket concepts, and a detailed evaluation of the most tractable design concepts. Tritium-breeding-blanket concepts were evaluated according to the proposed coolant. The ANL effort concentrated on evaluation of lithium- and water-cooled blanket designs while the MDAC effort focused on helium- and molten salt-cooled designs. A joint effort was undertaken to provide a consistent set of materials property data used for analysis of all blanket concepts. Generalized nuclear analysis of the tritium breeding performance, an analysis of tritium breeding requirements, and a first-wall stress analysis were conducted as part of the study. The impact of coolant selection on the mechanical design of a tokamak reactor was evaluated. Reference blanket designs utilizing the four candidate coolants are presented.

  7. Satisfiers and Dissatisfiers: A Two-Factor Model for Website Design and Evaluation.

    Science.gov (United States)

    Zhang, Ping; von Dran, Gisela M.

    2000-01-01

    Investigates Web site design factors and their impact from a theoretical perspective. Presents a two-factor model that can guide Web site design and evaluation. According to the model, there are two types of design factors: hygiene and motivator. Results showed that the two-factor model provides a means for Web-user interface studies. Provides…

  8. Green space system design in Luoyang using Huff model

    Science.gov (United States)

    Wang, Shengnan; Li, Meng

    2008-10-01

    Green space system, as part of the urban ecological environment and urban landscape, plays a significant role in the protection of biological diversity of the urban eco-systems. During the process of rapid modernization in China, it is evident that in order to satisfy the residents' needs of entertainment and communication effectively; there should be abundant types and adequate arrangement of green space. And at the same time a comprehensive and stable hierarchical structure of green space system ought to be established. Huff Model is widely used in facility location planning and service area segmentation in business geography, and has potentials in urban facility planning and design. This paper aims to evaluate, design and optimize the urban green space in Luoyang City, Henan Province, using GIS and Huff Model. Considering the existing location, size and shape of the green space supply, the spatial distribution of residence and the urban transportation systems, the attractiveness between residence and green space is estimated. The spatial pattern and service capability of the green space system are also evaluated critically. Based on the findings, the possible optimization design of the green space system in Luoyang is discussed innovatively. Huff model test shows that the design improves the overall spatial accessibility observably. The case study shows that GIS technology and Huff Model have great potential in urban green space evaluation, planning and design.

  9. TP-model transformation-based-control design frameworks

    CERN Document Server

    Baranyi, Péter

    2016-01-01

    This book covers new aspects and frameworks of control, design, and optimization based on the TP model transformation and its various extensions. The author outlines the three main steps of polytopic and LMI based control design: 1) development of the qLPV state-space model, 2) generation of the polytopic model; and 3) application of LMI to derive controller and observer. He goes on to describe why literature has extensively studied LMI design, but has not focused much on the second step, in part because the generation and manipulation of the polytopic form was not tractable in many cases. The author then shows how the TP model transformation facilitates this second step and hence reveals new directions, leading to powerful design procedures and the formulation of new questions. The chapters of this book, and the complex dynamical control tasks which they cover, are organized so as to present and analyze the beneficial aspect of the family of approaches (control, design, and optimization). Additionally, the b...

  10. Mirror Advanced Reactor Study interim design report

    Energy Technology Data Exchange (ETDEWEB)

    1983-04-01

    The status of the design of a tenth-of-a-kind commercial tandem-mirror fusion reactor is described at the midpoint of a two-year study. When completed, the design is to serve as a strategic goal for the mirror fusion program. The main objectives of the Mirror Advanced Reactor Study (MARS) are: (1) to design an attractive tandem-mirror fusion reactor producing electricity and synfuels (in alternate versions), (2) to identify key development and technology needs, and (3) to exploit the potential of fusion for safety, low activation, and simple disposal of radioactive waste. In the first year we have emphasized physics and engineering of the central cell and physics of the end cell. Design optimization and trade studies are continuing, and we expect additional modifications in the end cells to further improve the performance of the final design.

  11. Cryostat design case studies, principles and engineering

    CERN Document Server

    2016-01-01

    This book enables the reader to learn the fundamental and applied aspects of practical cryostat design by examining previous design choices and resulting cryostat performance. Through a series of extended case studies the book presents an overview of existing cryostat design covering a wide range of cryostat types and applications, including the magnet cryostats that comprise the majority of the Large Hadron Collider at CERN, space-borne cryostats containing sensors operating below 1 K, and large cryogenic liquid storage vessels. It starts with an introductory section on the principles of cryostat design including practical data and equations. This section is followed by a series of case studies on existing cryostats, describing the specific requirements of the cryostat, the challenges involved and the design choices made along with the resulting performance of the cryostat. The cryostat examples used in the studies are chosen to cover a broad range of cryostat applications and the authors of each case are ...

  12. User Assemblages in Design: An Ethnographic Study

    OpenAIRE

    2010-01-01

    This thesis presents an ethnographic study of the role of users in user-centered design. It is written from the perspective of science and technology studies, in particular developments in actor-network theory, and draws on the notion of the assemblage from the work of Deleuze and Guattari. The data for this thesis derives from a six-month field study of the routine discourse and practices of user-centered designers working for a multinational microprocessor manufacturer. The central argument...

  13. Teaching the Mixed Model Design: A Flowchart to Facilitate Understanding.

    Science.gov (United States)

    Mills, Jamie D.

    2005-01-01

    The Mixed Model (MM) design, sometimes known as a Split-Plot design, is very popular in educational research. This model can be used to examine the effects of several independent variables on a dependent variable and it offers a more powerful alternative to the completely randomized design. The MM design considers both a between-subjects factor,…

  14. PROSPECTS OF DESIGNING FLEXIBLE BUSINESS MODEL IN TURBULENT TIMES

    Directory of Open Access Journals (Sweden)

    Amalia DUTU

    2014-06-01

    Full Text Available The present study aims to analyze the current global context to capture the characteristics of the new type of volatile and turbulent business environment in which companies must operate nowdays and to bring some propositions in order to guide managers in designing or redesigning business models to achieve flexibility. The central message of this paper, that is a point of view one, is that, nowdays but also in the future, business models that are based on strategic, organizational and operational flexibility and on reaction speed will be those who will provide the greatest capacity to respond to change. Even if the international theory provides a multiple perspective analysis of business model concept, still how it can be achieved such flexibility remains an open issue in the academic debate, but also in the practice of companies. Thus, the paper contains some propositions in order to guide managers in the process of designing or redesigning the business model.

  15. Designing Multi-target Compound Libraries with Gaussian Process Models.

    Science.gov (United States)

    Bieler, Michael; Reutlinger, Michael; Rodrigues, Tiago; Schneider, Petra; Kriegl, Jan M; Schneider, Gisbert

    2016-05-01

    We present the application of machine learning models to selecting G protein-coupled receptor (GPCR)-focused compound libraries. The library design process was realized by ant colony optimization. A proprietary Boehringer-Ingelheim reference set consisting of 3519 compounds tested in dose-response assays at 11 GPCR targets served as training data for machine learning and activity prediction. We compared the usability of the proprietary data with a public data set from ChEMBL. Gaussian process models were trained to prioritize compounds from a virtual combinatorial library. We obtained meaningful models for three of the targets (5-HT2c , MCH, A1), which were experimentally confirmed for 12 of 15 selected and synthesized or purchased compounds. Overall, the models trained on the public data predicted the observed assay results more accurately. The results of this study motivate the use of Gaussian process regression on public data for virtual screening and target-focused compound library design.

  16. Electricity Market Manipulation: How Behavioral Modeling Can Help Market Design

    Energy Technology Data Exchange (ETDEWEB)

    Gallo, Giulia [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-12-18

    The question of how to best design electricity markets to integrate variable and uncertain renewable energy resources is becoming increasingly important as more renewable energy is added to electric power systems. Current markets were designed based on a set of assumptions that are not always valid in scenarios of high penetrations of renewables. In a future where renewables might have a larger impact on market mechanisms as well as financial outcomes, there is a need for modeling tools and power system modeling software that can provide policy makers and industry actors with more realistic representations of wholesale markets. One option includes using agent-based modeling frameworks. This paper discusses how key elements of current and future wholesale power markets can be modeled using an agent-based approach and how this approach may become a useful paradigm that researchers can employ when studying and planning for power systems of the future.

  17. Mixed sensitivity design: An aerospace case study

    NARCIS (Netherlands)

    Kwakernaak, Huibert; Camacho, E.F.; Basanez, L.; Puente, de la J.A.

    2002-01-01

    The mixed sensitivity design method for multivariable linear control systems proposed in the companion paper (Kwakernaak, 2001) is applied to the design of a stability augmentation system for the longitudinal motion of a fighter airplane previously studied by Safonov and Chiang (1988). Both $H_\\inft

  18. Simulation models and designs for advanced Fischer-Tropsch technology

    Energy Technology Data Exchange (ETDEWEB)

    Choi, G.N.; Kramer, S.J.; Tam, S.S. [Bechtel Corp., San Francisco, CA (United States)

    1995-12-31

    Process designs and economics were developed for three grass-roots indirect Fischer-Tropsch coal liquefaction facilities. A baseline and an alternate upgrading design were developed for a mine-mouth plant located in southern Illinois using Illinois No. 6 coal, and one for a mine-mouth plane located in Wyoming using Power River Basin coal. The alternate design used close-coupled ZSM-5 reactors to upgrade the vapor stream leaving the Fischer-Tropsch reactor. ASPEN process simulation models were developed for all three designs. These results have been reported previously. In this study, the ASPEN process simulation model was enhanced to improve the vapor/liquid equilibrium calculations for the products leaving the slurry bed Fischer-Tropsch reactors. This significantly improved the predictions for the alternate ZSM-5 upgrading design. Another model was developed for the Wyoming coal case using ZSM-5 upgrading of the Fischer-Tropsch reactor vapors. To date, this is the best indirect coal liquefaction case. Sensitivity studies showed that additional cost reductions are possible.

  19. Nuclear-Powered GPS Spacecraft Design Study

    Energy Technology Data Exchange (ETDEWEB)

    Raab, Bernard

    1977-05-01

    This is the final report of a study to investigate the potential benefits of a nuclear (radioisotope) - powered satellite for advanced phases of the Global Positioning System (GPS) program. The critical parameters were: power to user; mean mission duration; orbital predictability; thermal control of on-board frequency standards; and vulnerability. The reference design approach is described, and input data are given for two power systems that are under development: an organic Rankine system and a Brayton cycle system. Reference design details are provided and structural design and analysis are discussed, as well as thermal design and analysis. A higher altitude version is also considered.

  20. Flight Path Recovery System (FPRS) design study

    Energy Technology Data Exchange (ETDEWEB)

    1978-09-01

    The study contained herein presents a design for a Flight Path Recovery System (FPPS) for use in the NURE Program which will be more accurate than systems presently used, provide position location data in digital form suitable for automatic data processing, and provide for flight path recovery in a more economic and operationally suitable manner. The design is based upon the use of presently available hardware and technoloy, and presents little, it any, development risk. In addition, a Flight Test Plan designed to test the FPRS design concept is presented.

  1. Content Analysis of Research Trends in Instructional Design Models: 1999-2014

    Science.gov (United States)

    Göksu, Idris; Özcan, Kursat Volkan; Çakir, Recep; Göktas, Yuksel

    2017-01-01

    This study examines studies on instructional design models by applying content analysis. It covers 113 papers published in 44 international Social Science Citation Index (SSCI) and Science Citation Index (SCI) journals. Studies on instructional design models are explored in terms of journal of publication, preferred model, country where the study…

  2. Designing for Learning and Play - The Smiley Model as Framework

    DEFF Research Database (Denmark)

    Weitze, Charlotte Lærke

    2016-01-01

    This paper presents a framework for designing engaging learning experiences in games – the Smiley Model. In this Design-Based Research project, student-game-designers were learning inside a gamified learning design - while designing and implementing learning goals from curriculum into the small d...

  3. Sequential design approaches for bioequivalence studies with crossover designs.

    Science.gov (United States)

    Potvin, Diane; DiLiberti, Charles E; Hauck, Walter W; Parr, Alan F; Schuirmann, Donald J; Smith, Robert A

    2008-01-01

    The planning of bioequivalence (BE) studies, as for any clinical trial, requires a priori specification of an effect size for the determination of power and an assumption about the variance. The specified effect size may be overly optimistic, leading to an underpowered study. The assumed variance can be either too small or too large, leading, respectively, to studies that are underpowered or overly large. There has been much work in the clinical trials field on various types of sequential designs that include sample size reestimation after the trial is started, but these have seen only little use in BE studies. The purpose of this work was to validate at least one such method for crossover design BE studies. Specifically, we considered sample size reestimation for a two-stage trial based on the variance estimated from the first stage. We identified two methods based on Pocock's method for group sequential trials that met our requirement for at most negligible increase in type I error rate.

  4. A Model of Research Paper Writing Instructional Materials for Academic Writing Course: "Needs & Documents Analysis and Model Design"

    Science.gov (United States)

    Ghufron, M. Ali; Saleh, Mursid; Warsono; Sofwan, Ahmad

    2016-01-01

    This study aimed at designing a model of instructional materials for Academic Writing Course focusing on research paper writing. The model was designed based on the Curriculum at the English Education Study Program, Faculty of Language and Art Education of IKIP PGRI Bojonegoro, East Java, Indonesia. This model was developed in order to improve…

  5. Research Design in Marital Adjustment Studies.

    Science.gov (United States)

    Croake, James W.; Lyon, Rebecca S.

    1978-01-01

    The numerous marital adjustment studies which exist in the literature are confounded by basic design problems. Marital stability should be the baseline for data. It is then possible to discuss "happiness,""success,""adjustment," and "satisfaction." (Author)

  6. Studying Design Engineers Use Of Information Systems

    DEFF Research Database (Denmark)

    Restrepo-Giraldo, John Dairo

    2006-01-01

    Studying information usage by design engineers involves considering technical, social, cognitive and volitional factors. This makes it challenging, especially for researchers without a cognitive psychology background. This paper presents a summary of key findings in researching information use...

  7. The Architectural Designs of a Nanoscale Computing Model

    Directory of Open Access Journals (Sweden)

    Mary M. Eshaghian-Wilner

    2004-08-01

    Full Text Available A generic nanoscale computing model is presented in this paper. The model consists of a collection of fully interconnected nanoscale computing modules, where each module is a cube of cells made out of quantum dots, spins, or molecules. The cells dynamically switch between two states by quantum interactions among their neighbors in all three dimensions. This paper includes a brief introduction to the field of nanotechnology from a computing point of view and presents a set of preliminary architectural designs for fabricating the nanoscale model studied.

  8. The Architectural Designs of a Nanoscale Computing Model

    Directory of Open Access Journals (Sweden)

    Mary M. Eshaghian-Wilner

    2004-08-01

    Full Text Available A generic nanoscale computing model is presented in this paper. The model consists of a collection of fully interconnected nanoscale computing modules, where each module is a cube of cells made out of quantum dots, spins, or molecules. The cells dynamically switch between two states by quantum interactions among their neighbors in all three dimensions. This paper includes a brief introduction to the field of nanotechnology from a computing point of view and presents a set of preliminary architectural designs for fabricating the nanoscale model studied.

  9. Model-Based Design of Tree WSNs for Decentralized Detection.

    Science.gov (United States)

    Tantawy, Ashraf; Koutsoukos, Xenofon; Biswas, Gautam

    2015-08-20

    The classical decentralized detection problem of finding the optimal decision rules at the sensor and fusion center, as well as variants that introduce physical channel impairments have been studied extensively in the literature. The deployment of WSNs in decentralized detection applications brings new challenges to the field. Protocols for different communication layers have to be co-designed to optimize the detection performance. In this paper, we consider the communication network design problem for a tree WSN. We pursue a system-level approach where a complete model for the system is developed that captures the interactions between different layers, as well as different sensor quality measures. For network optimization, we propose a hierarchical optimization algorithm that lends itself to the tree structure, requiring only local network information. The proposed design approach shows superior performance over several contentionless and contention-based network design approaches.

  10. Model-Based Design of Tree WSNs for Decentralized Detection

    Directory of Open Access Journals (Sweden)

    Ashraf Tantawy

    2015-08-01

    Full Text Available The classical decentralized detection problem of finding the optimal decision rules at the sensor and fusion center, as well as variants that introduce physical channel impairments have been studied extensively in the literature. The deployment of WSNs in decentralized detection applications brings new challenges to the field. Protocols for different communication layers have to be co-designed to optimize the detection performance. In this paper, we consider the communication network design problem for a tree WSN. We pursue a system-level approach where a complete model for the system is developed that captures the interactions between different layers, as well as different sensor quality measures. For network optimization, we propose a hierarchical optimization algorithm that lends itself to the tree structure, requiring only local network information. The proposed design approach shows superior performance over several contentionless and contention-based network design approaches.

  11. Conceptual model for the design of product systems

    Directory of Open Access Journals (Sweden)

    John J. Cardozo Vásquez

    2016-08-01

    Full Text Available Based on the concepts of personalization, differentiation and variability, product systems are characterized and the conditions for their design are explored. In the analysis of literature,17 variables related to the design of product systems were identified, and used to develop a conceptual model. In order to validate this finding, a survey was applied to 57 experts in the field of design. By means of a factor analysis, variables are reduced and the underlying conceptual relationships are identified. As a result of the validation, three factors are identified: structure, coherence and order, which contain the variables that determine the attributes of the product systems. These findings support the conclusion that the origin of the design process of these systems is based on the analysis of consumers and the multiple uses given and experiences obtained from these products. Study boundaries are established and future research possibilities are outlined.

  12. A Model of Reading Teaching for University EFL Students: Need Analysis and Model Design

    Science.gov (United States)

    Hamra, Arifuddin; Syatriana, Eny

    2012-01-01

    This study designed a model of teaching reading for university EFL students based on the English curriculum at the Faculty of Languages and Literature and the concept of the team-based learning in order to improve the reading comprehension of the students. What kind of teaching model can help students to improve their reading comprehension? The…

  13. Design and Analysis of Salmonid Tagging Studies in the Columbia Basin. Volume III, Experiment Designs and Statistical Models to Estimate the Effect of Transportation on Survival of Columbia River System Salmonids.

    Energy Technology Data Exchange (ETDEWEB)

    Newman, Ken

    1997-06-01

    Experiment designs to estimate the effect of transportation on survival and return rates of Columbia River system salmonids are discussed along with statistical modeling techniques. Besides transportation, river flow and dam spill are necessary components in the design and analysis, otherwise questions as to the effects of reservoir drawdowns and increased dam spill may never be satisfactorily answered. Four criteria for comparing different experiment designs are: (1) feasibility; (2) clarity of results; (3) scope of inference; and (4) time to learn. A controlled experiment with treatments that are a combination of transport status (transported or left in-river), river flow level, and dam spill level should provide the clearest results of transport effect. The potential for bias due to interactions between year effects and the treatments is minimized by running as many treatments as possible within a single outmigration year. Relatedly, the most rapid learning will occur if several different treatments are implemented at randomly chosen time periods within thesame outmigration season. If the range of flow and dam manipulation includes scenarios of interest to managers, the scope of inference should be satisfactory. On the other hand these designs may be the least feasible; trying to manage the river system under a sequence of deliberately chosen flow regimes within a single season, for example, may be quite impractical. At the other end of the spectrum are designs that simply have two treatment combinations, transportation and being left in-river, and the influence of flow and spill are controlled for, if possible, in after-the-fact statistical analysis. Because of possible confounding influences of flow and spill on the transportation effect, these designs could yield the most ambiguous results and require the most years of experimentation to learn. If flows and spill are not manipulated in a planned, well defined, and impartial manner the scope and quality of

  14. Concept Model For Designing Engaging And Motivating Games For Learning - The Smiley-Model

    DEFF Research Database (Denmark)

    Weitze, Charlotte Lærke; Ørngreen, Rikke

    2012-01-01

    a music learning game that teaches children to play piano using sheet music, and at the same time is fun and engaging. Although the model was originally developed for and through music, it has a more generic nature, and may be relevant for other fields as well. The Smiley-model is a condensed version...... that is believed to be an advantage when using learning games in education. In this paper the Smiley-model is presented (figure 1). The model describes which parameters and elements are important when designing a learning game. The present research is a result of a case-based action research study for designing...... of a design manual developed in a Master's thesis (Weitze, 2011), created on the basis of theoretical and empirical analysis, and is currently being applied to other research projects. The research concerning design for learning was carried out with an analysis of specific and general learning theory...

  15. Computer aided polymer design using multi-scale modelling

    Directory of Open Access Journals (Sweden)

    K. C. Satyanarayana

    2010-09-01

    Full Text Available The ability to predict the key physical and chemical properties of polymeric materials from their repeat-unit structure and chain-length architecture prior to synthesis is of great value for the design of polymer-based chemical products, with new functionalities and improved performance. Computer aided molecular design (CAMD methods can expedite the design process by establishing input-output relations between the type and number of functional groups in a polymer repeat unit and the desired macroscopic properties. A multi-scale model-based approach that combines a CAMD technique based on group contribution plus models for predicting polymer repeat unit properties with atomistic simulations for providing first-principles arrangements of the repeat units and for predictions of physical properties of the chosen candidate polymer structures, has been developed and tested for design of polymers with desired properties. A case study is used to highlight the main features of this multi-scale model-based approach for the design of a polymer-based product.

  16. Robustness of optimal designs for the Michaelis-Menten model under a variation of criteria

    OpenAIRE

    Dette, Holger; Kiss, Christine; Wong, Weng Kee

    2009-01-01

    The Michaelis-Menten model has and continues to be one of the most widely used models in many diverse fields. In the biomedical sciences, the model continues to be ubiquitous in biochemistry, enzyme kinetics studies, nutrition science and in the pharmaceutical sciences. Despite its wide ranging applications across disciplines, design issues for this model are given short shrift. This paper focuses on design issues and provides a variety of optimal designs of this model. In addition, we ...

  17. System and method of designing models in a feedback loop

    Energy Technology Data Exchange (ETDEWEB)

    Gosink, Luke C.; Pulsipher, Trenton C.; Sego, Landon H.

    2017-02-14

    A method and system for designing models is disclosed. The method includes selecting a plurality of models for modeling a common event of interest. The method further includes aggregating the results of the models and analyzing each model compared to the aggregate result to obtain comparative information. The method also includes providing the information back to the plurality of models to design more accurate models through a feedback loop.

  18. Advancing engagement methods for trials: the CORE study relational model of engagement for a stepped wedge cluster randomised controlled trial of experience-based co-design for people living with severe mental illnesses.

    Science.gov (United States)

    Richard, Lauralie; Piper, Donella; Weavell, Wayne; Callander, Rosemary; Iedema, Rick; Furler, John; Pierce, David; Godbee, Kali; Gunn, Jane; Palmer, Victoria J

    2017-04-08

    Engagement is essential in trials research but is rarely embedded across all stages of the research continuum. The development, use, effectiveness and value of engagement in trials research is poorly researched and understood, and models of engagement are rarely informed by theory. This article describes an innovative methodological approach for the development and application of a relational model of engagement in a stepped wedge designed cluster randomised controlled trial (RCT), the CORE study. The purpose of the model is to embed engagement across the continuum of the trial which will test if an experience-based co-design intervention improves psychosocial recovery for people affected by severe mental illness. The model was developed in three stages and used a structured iterative approach. A context mapping assessment of trial sites was followed by a literature review on recruitment and retention of hard-to-reach groups in complex interventions and RCTs. Relevant theoretical and philosophical underpinnings were identified by an additional review of literature to inform model development and enactment of engagement activities. Policy, organisational and service user data combined with evidence from the literature on barriers to recruitment provided contextual information. Four perspectives support the theoretical framework of the relational model of engagement and this is organised around two facets: the relational and continuous. The relational facet is underpinned by relational ethical theories and participatory action research principles. The continuous facet is supported by systems thinking and translation theories. These combine to enact an ethics of engagement and evoke knowledge mobilisation to reach the higher order goals of the model. Engagement models are invaluable for trials research, but there are opportunities to advance their theoretical development and application, particularly within stepped wedge designed studies where there may be a

  19. Developing a Kano-Based Evaluation Model for Innovation Design

    Directory of Open Access Journals (Sweden)

    Chang-Tzuoh Wu

    2015-01-01

    Full Text Available This research focuses on developing a psychology-based evaluation procedure for innovative design. The divergent thinking part of the main innovative design procedure which discussed in this paper is the extensive QFD developed by the author (Wu. The major performance of QFD is to identify the customers’ requirements and their priorities. Then, the proposed extensive QFD helps transform the high priority requirements into appropriate technical characteristics. According to the priorities of product characteristics, the prior engineering parameters will be identified to be the key performances to redesign. For identifying the requirements and achieving the attractive design, we introduce the Kano model to construct the evaluation model. The proposed Kano-based evaluation procedure is mainly used in two stages of the innovative design. First, the evaluation process was used in QFD stage to help identify attractive customers’ requirements, and the other was used in the extension stage to help assess concepts. The flowchart of proposed innovative design procedure with psychology-based evaluation has also been developed. A case study, exercise equipment design, is adopted to explain and verify feasibility of the proposed approach.

  20. Property Modelling for Applications in Chemical Product and Process Design

    DEFF Research Database (Denmark)

    Gani, Rafiqul

    Physical-chemical properties of pure chemicals and their mixtures play an important role in the design of chemicals based products and the processes that manufacture them. Although, the use of experimental data in design and analysis of chemicals based products and their processes is desirable...... such as database, property model library, model parameter regression, and, property-model based product-process design will be presented. The database contains pure component and mixture data for a wide range of organic chemicals. The property models are based on the combined group contribution and atom...... modeling tools in design and analysis of chemical product-process design, including biochemical processes will be highlighted....

  1. A global parallel model based design of experiments method to minimize model output uncertainty.

    Science.gov (United States)

    Bazil, Jason N; Buzzard, Gregory T; Rundell, Ann E

    2012-03-01

    Model-based experiment design specifies the data to be collected that will most effectively characterize the biological system under study. Existing model-based design of experiment algorithms have primarily relied on Fisher Information Matrix-based methods to choose the best experiment in a sequential manner. However, these are largely local methods that require an initial estimate of the parameter values, which are often highly uncertain, particularly when data is limited. In this paper, we provide an approach to specify an informative sequence of multiple design points (parallel design) that will constrain the dynamical uncertainty of the biological system responses to within experimentally detectable limits as specified by the estimated experimental noise. The method is based upon computationally efficient sparse grids and requires only a bounded uncertain parameter space; it does not rely upon initial parameter estimates. The design sequence emerges through the use of scenario trees with experimental design points chosen to minimize the uncertainty in the predicted dynamics of the measurable responses of the system. The algorithm was illustrated herein using a T cell activation model for three problems that ranged in dimension from 2D to 19D. The results demonstrate that it is possible to extract useful information from a mathematical model where traditional model-based design of experiments approaches most certainly fail. The experiments designed via this method fully constrain the model output dynamics to within experimentally resolvable limits. The method is effective for highly uncertain biological systems characterized by deterministic mathematical models with limited data sets. Also, it is highly modular and can be modified to include a variety of methodologies such as input design and model discrimination.

  2. HYPERSTATIC STRUCTURE MAPPING MODEL BUILDING AND OPTIMIZING DESIGN

    Institute of Scientific and Technical Information of China (English)

    XU Gening; GAO Youshan; ZHANG Xueliang; YANG Ruigang

    2007-01-01

    Hyperstatic structure plane model being built by structural mechanics is studied. Space model precisely reflected in real stress of the structure is built by finite element method (FEM) analysis commerce software. Mapping model of complex structure system is set up, with convenient calculation just as in plane model and comprehensive information as in space model. Plane model and space model are calculated under the same working condition. Plane model modular construction inner force is considered as input data; Space model modular construction inner force is considered as output data. Thus specimen is built on input data and output data. Character and affiliation are extracted through training specimen, with the employment of nonlinear mapping capability of the artificial neural network. Mapping model with interpolation and extrapolation is gained, laying the foundation for optimum design. The steel structure of high-layer parking system (SSHLPS) is calculated as an instance. A three-layer back-propagation (BP) net including one hidden layer is constructed with nine input nodes and eight output nodes for a five-layer SSHLPS. The three-layer structure optimization result through the mapping model interpolation contrasts with integrity re-analysis, and seven layers structure through the mapping model extrapolation contrasts with integrity re-analysis. Any layer SSHLPS among 1~8 can be calculated with much accuracy. Amount of calculation can also be reduced if it is applied into the same topological structure, with reduced distortion and assured precision.

  3. Modeling and Design of Container Terminal Operations

    NARCIS (Netherlands)

    D. Roy (Debjit); M.B.M. de Koster (René)

    2014-01-01

    textabstractDesign of container terminal operations is complex because multiple factors affect the operational perfor- mance. These factors include: topological constraints, a large number of design parameters and settings, and stochastic interactions that interplay among the quayside, vehicle trans

  4. Transformation: Structure/space studies in bionics and space design

    Science.gov (United States)

    Gruber, Petra; Imhof, Barbara

    2007-02-01

    This paper discusses the architectural design project "Transformation Structure Space", which was carried out at the Department of Building Construction HB2 in 2004. The goal of the study was to find innovative solutions for space system design through the application of bionic (biomimetic) approaches. Using specific research both fields as the foundation, five different architectural projects based on a scientific-technological concept were developed. The introduction of natural role models into the design process and the development of the application in space and the respective setting proved to be a difficult task within the timeframe of a design program, nonetheless all of the projects show very innovative aspects.

  5. Modeling and design techniques for RF power amplifiers

    CERN Document Server

    Raghavan, Arvind; Laskar, Joy

    2008-01-01

    The book covers RF power amplifier design, from device and modeling considerations to advanced circuit design architectures and techniques. It focuses on recent developments and advanced topics in this area, including numerous practical designs to back the theoretical considerations. It presents the challenges in designing power amplifiers in silicon and helps the reader improve the efficiency of linear power amplifiers, and design more accurate compact device models, with faster extraction routines, to create cost effective and reliable circuits.

  6. Design issues for the Michaelis-Menten model.

    Science.gov (United States)

    López-Fidalgo, J; Wong, Weng Kee

    2002-03-07

    We discuss design issues for the Michaelis-Menten model and use geometrical arguments to find optimal designs for estimating a subset of the model parameters, or a linear combination of the parameters. We propose multiple-objective optimal designs when the parameters have different levels of interest to the researcher. In addition, we compare six commonly used sequence designs in the biological sciences for estimating parameters and, propose optimal choices for the parameters for geometric designs using closed-form efficiency formulas.

  7. Light and shadow modelling study in the original design of the game%游戏原画设计中光影造型的研究

    Institute of Scientific and Technical Information of China (English)

    王莉; 姜仁峰

    2015-01-01

    对于游戏原画画面的基调,光影造型是其中基本影响因素之一,但却是最直观的.光影常用于游戏原画创作中,光影对画面的影响比较大,影响着画面的细腻度、情绪、画面的感染力等等,光影对形体的塑造值得深入研究.另外,光影造型是游戏原画设计中经常容易被忽视的一个重要元素,它以明暗布局的形式来暗喻游戏中物体的体积感和画面强烈的空间感.%For the visuals of the game screen tone, light and shadow is one of the basic factors affecting the modelling, but it is the most intuitive. Light is often used in the original painting creation of the game, light and shadow have a larger impact on the image, affects the smooth of the picture, the appeal of emotion, image and so on, light and shadow to form shape is worthy of further research. In addition, the modelling of light and shadow is often overlooked in the design of the original game is an important element, it takes the form of light and shade layout to metaphor object of the game's strong sense of volume and picture.

  8. The Study of Fashion-design Intellectual Property Protection Model%时装设计的知识产权保护模式研究

    Institute of Scientific and Technical Information of China (English)

    陈晓屏

    2016-01-01

    现行的知识产权分散保护机制与时装设计的固有属性存在契合障碍,难以有效地规制仿冒和抄袭时装设计现象。尤其在当下,科技发展与时装业经营模式的变化导致相关主体的利益实现方式和行为决策发生改变,时装业不仅应当引入更强的知识产权保护机制,而且应在机制选择和建构时充分考虑产业快速变化的特点,重构一种以各方利益的动态平衡为核心的制度资源配置方式。%The current intellectual property protection system and the nature of fashion design are not effective,which cannot stop plagiarism. The development of science and tech-nology and the marketing model of fashion industry have changed the interest implementation model and decision making. A stronger intellectual property protection system should be in-troduced into the fashion industry. While choosing and constructing the protection system, the rapid change of this industry should be considered. The system with a dynamic balance of all party’ s interest is preferred.

  9. Graphical Models for Quasi-Experimental Designs

    Science.gov (United States)

    Kim, Yongnam; Steiner, Peter M.; Hall, Courtney E.; Su, Dan

    2016-01-01

    Experimental and quasi-experimental designs play a central role in estimating cause-effect relationships in education, psychology, and many other fields of the social and behavioral sciences. This paper presents and discusses the causal graphs of experimental and quasi-experimental designs. For quasi-experimental designs the authors demonstrate…

  10. Vestibular models for design and evaluation of flight simulator motion

    Science.gov (United States)

    Bussolari, S. R.; Sullivan, R. B.; Young, L. R.

    1986-01-01

    The use of spatial orientation models in the design and evaluation of control systems for motion-base flight simulators is investigated experimentally. The development of a high-fidelity motion drive controller using an optimal control approach based on human vestibular models is described. The formulation and implementation of the optimal washout system are discussed. The effectiveness of the motion washout system was evaluated by studying the response of six motion washout systems to the NASA/AMES Vertical Motion Simulator for a single dash-quick-stop maneuver. The effects of the motion washout system on pilot performance and simulator acceptability are examined. The data reveal that human spatial orientation models are useful for the design and evaluation of flight simulator motion fidelity.

  11. DEFICIENT INFORMATION MODELING OF MECHANICAL PRODUCTS FOR CONCEPTUAL SHAPE DESIGN

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    In allusion to the deficient feature of product information in conceptual design, a framework of deficient information modeling for conceptual shape design is put forward, which includes qualitative shape modeling (a qualitative solid model), uncertain shape modeling (an uncertain relation model) and imprecise shape modeling (an imprecise region model). In the framework, the qualitative solid model is the core, which represents qualitatively (using symbols) the conceptual shapes of mechanical products. The uncertain relation model regarding domain relations as objects and the imprecise region model regarding domains as objects are used to deal with the uncertain and imprecise issues respectively, which arise from qualitative shape modeling or exist in product information itself.

  12. A Conceptual Model for Planning and Designing Healthy Urban Landscapes in the Third World: A study of Street Vendors in the Philippines

    Directory of Open Access Journals (Sweden)

    Timothy Akers

    2004-06-01

    Full Text Available Typical urban street landscapes in the third world are dotted with tiny businesses. Street vendors, who are predominantly women, belong to a sector called the 'informal economy'. Unregistered and unregulated, these informal businesses are owned by poor, marginalised groups who depend on them as alternative sources of income for basic survival. In the Philippines, the informal sector constitutes 50 percent of the country's Gross National Product (GNP (Enste and Schneider, 1998.This paper examines the impact of urban environmental features and economic status on the health conditions of the vendors. The outcome is a model process involving participation of vendors in the development of planning and design solutions. A survey of 187 vendors in Baguio City in the Philippines was conducted in December 2003. Baguio City is a northern upland regional centre with a population of about 250,000. Located 5,000 feet above sea level, the city's climate is temperate with an average of 70-75 Fahrenheit (20-25 Celsius throughout the year. From June to October, the city receives the heaviest rainfall in the entire country.

  13. Spectroscopic Studies of Model Photo-Receptors: Validation of a Nanosecond Time-Resolved Micro-Spectrophotometer Design Using Photoactive Yellow Protein and α-Phycoerythrocyanin

    Directory of Open Access Journals (Sweden)

    Marius Schmidt

    2013-09-01

    Full Text Available Time-resolved spectroscopic experiments have been performed with protein in solution and in crystalline form using a newly designed microspectrophotometer. The time-resolution of these experiments can be as good as two nanoseconds (ns, which is the minimal response time of the image intensifier used. With the current setup, the effective time-resolution is about seven ns, determined mainly by the pulse duration of the nanosecond laser. The amount of protein required is small, on the order of 100 nanograms. Bleaching, which is an undesirable effect common to photoreceptor proteins, is minimized by using a millisecond shutter to avoid extensive exposure to the probing light. We investigate two model photoreceptors, photoactive yellow protein (PYP, and α-phycoerythrocyanin (α-PEC, on different time scales and at different temperatures. Relaxation times obtained from kinetic time-series of difference absorption spectra collected from PYP are consistent with previous results. The comparison with these results validates the capability of this spectrophotometer to deliver high quality time-resolved absorption spectra.

  14. Mooring Design for the Floating Oscillating Water Column Reference Model

    Energy Technology Data Exchange (ETDEWEB)

    Brefort, Dorian [Univ. of Michigan, Ann Arbor, MI (United States); Bull, Diana L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-09-01

    To reduce the price of the reference Backward Bent Duct Buoy (BBDB), a study was done analyzing the effects of reducing the mooring line length, and a new mooring design was developed. It was found that the overall length of the mooring lines could be reduced by 1290 meters, allowing a significant price reduction of the system. In this paper, we will first give a description of the model and the storm environment it will be subject to. We will then give a recommendation for the new mooring system, followed by a discussion of the severe weather simulation results, and an analysis of the conservative and aggressive aspects of the design.

  15. Controlled air incinerator conceptual design study

    Energy Technology Data Exchange (ETDEWEB)

    1982-01-01

    This report presents a conceptual design study for a controlled air incinerator facility for incineration of low level combustible waste at Three Mile Island Unit 2 (TMI-2). The facility design is based on the use of a Helix Process Systems controlled air incinerator. Cost estimates and associated engineering, procurement, and construction schedules are also provided. The cost estimates and schedules are presented for two incinerator facility designs, one with provisions for waste ash solidification, the other with provisions for packaging the waste ash for transport to an undefined location.

  16. Engineering study for ISSTRS design concept

    Energy Technology Data Exchange (ETDEWEB)

    Hertzel, J.S.

    1997-01-31

    Los Alamos Technical Associates, Inc., is pleased to transmit the attached Conceptual Design Package for the Initial Single Shell Tank Retrieval System (ISSTRS), 90% Conceptual Design Review. The package includes the following: (1) ISSTRS Trade Studies: (a) Retrieval Facility Cooling Requirements; (b) Equipment Re-usability between Project W-320 and Tanks 241-C-103 and 241-C-1 05; (c) Sluice Line Options; and (d) Options for the Location of Tanks AX-103 and A-1 02 HVAC Equipment; (2) Drawings; (3) Risk Management Plan; (4) 0850 Interface Control Document; (5) Requirements Traceability Report; and (6) Project Design Specification.

  17. Sound in new media and design studies

    OpenAIRE

    Özcan, Oğuzhan; Tahiroğlu, Koray; Ikonen, Antti

    2014-01-01

    56 DesignIssues: Volume 30, Number 2 Spring 2014 © 2014 Massachusetts Institute of Technology Sound in New Media and Design Studies Koray Tahiro˘glu, O˘guzhan Özcan, Antti Ikonen Introduction The effect of new media on the computerization of cultural prac-tices has moved to a new level and has become more open, com-mon, and prevailing as we deal with new forms of artistic creation and design processes in supporting higher education. Massive changes have occurr...

  18. PECULIARITIES OF CLOTHES MODELLING BY MEANS OF GRAPHIC DESIGN

    OpenAIRE

    Fatima Mustafa OBARI

    2014-01-01

    The paper examined some aspects of fashion design for garments with application of graphic design software/ facilities. The study focused on the course of designing with the graphics software, creating the dimensional and extensive environment, which influenced the shaping of a garment and alterations to within the scope of current trends in fashion design. The study observed creative sketching and designing tasks, a designed shape, an artist vision of the item in the graphic design. The pape...

  19. A Design of Product Collaborative Online Configuration Model

    Science.gov (United States)

    Wang, Xiaoguo; Zheng, Jin; Zeng, Qian

    According to the actual needs of mass customization, the personalization of product and its collaborative design, the paper analyzes and studies the working mechanism of modular-based product configuration technology and puts forward an information model of modular product family. Combined with case-based reasoning techniques (CBR) and the constraint satisfaction problem solving techniques (CSP), we design and study the algorithm for product configuration, and analyze its time complexity. A car chassis is made as the application object, we provide a prototype system of online configuration. Taking advantage of this system, designers can make appropriate changes on the existing programs in accordance with the demand. This will accelerate all aspects of product development and shorten the product cycle. Also the system will provide a strong technical support for enterprises to improve their market competitiveness.

  20. Transparent composite model for DCT coefficients: design and analysis.

    Science.gov (United States)

    Yang, En-Hui; Yu, Xiang; Meng, Jin; Sun, Chang

    2014-03-01

    The distributions of discrete cosine transform (DCT) coefficients of images are revisited on a per image base. To better handle, the heavy tail phenomenon commonly seen in the DCT coefficients, a new model dubbed a transparent composite model (TCM) is proposed and justified for both modeling accuracy and an additional data reduction capability. Given a sequence of the DCT coefficients, a TCM first separates the tail from the main body of the sequence. Then, a uniform distribution is used to model the DCT coefficients in the heavy tail, whereas a different parametric distribution is used to model data in the main body. The separate boundary and other parameters of the TCM can be estimated via maximum likelihood estimation. Efficient online algorithms are proposed for parameter estimation and their convergence is also proved. Experimental results based on Kullback-Leibler divergence and χ(2) test show that for real-valued continuous ac coefficients, the TCM based on truncated Laplacian offers the best tradeoff between modeling accuracy and complexity. For discrete or integer DCT coefficients, the discrete TCM based on truncated geometric distributions (GMTCM) models the ac coefficients more accurately than pure Laplacian models and generalized Gaussian models in majority cases while having simplicity and practicality similar to those of pure Laplacian models. In addition, it is demonstrated that the GMTCM also exhibits a good capability of data reduction or feature extraction-the DCT coefficients in the heavy tail identified by the GMTCM are truly outliers, and these outliers represent an outlier image revealing some unique global features of the image. Overall, the modeling performance and the data reduction feature of the GMTCM make it a desirable choice for modeling discrete or integer DCT coefficients in the real-world image or video applications, as summarized in a few of our further studies on quantization design, entropy coding design, and image understanding

  1. Distribution Network Design--literature study based

    OpenAIRE

    Li, Ang

    2012-01-01

    The focus of this research is companies' outbound distribution network design in supply chain management. Within the present competitive market, it is a fundamental importance for companies to achieve high level business performance with an effective supply chain. Outbound distribution network design as an important part in supply chain management, to a large extent decides whether companies can fulfill customers' requirement or not. Therefore, such a study is important for manufacturers and ...

  2. Designer Modeling for Personalized Game Content Creation Tools

    DEFF Research Database (Denmark)

    Liapis, Antonios; Yannakakis, Georgios N.; Togelius, Julian

    2013-01-01

    With the growing use of automated content creation and computer-aided design tools in game development, there is potential for enhancing the design process through personalized interactions between the software and the game developer. This paper proposes designer modeling for capturing the designer......’s preferences, goals and processes from their interaction with a computer-aided design tool, and suggests methods and domains within game development where such a model can be applied. We describe how designer modeling could be integrated with current work on automated and mixed-initiative content creation...

  3. Automatically Creating Design Models from 3D Anthropometry Data

    CERN Document Server

    Wuhrer, Stefanie; Bose, Prosenjit

    2011-01-01

    When designing a product that needs to fit the human shape, designers often use a small set of 3D models, called design models, either in physical or digital form, as representative shapes to cover the shape variabilities of the population for which the products are designed. Until recently, the process of creating these models has been an art involving manual interaction and empirical guesswork. The availability of the 3D anthropometric databases provides an opportunity to create design models optimally. In this paper, we propose a novel way to use 3D anthropometric databases to generate design models that represent a given population for design applications such as the sizing of garments and gear. We generate the representative shapes by solving a covering problem in a parameter space. Well-known techniques in computational geometry are used to solve this problem. We demonstrate the method using examples in designing glasses and helmets.

  4. Biomembrane Frontiers Nanostructures, Models, and the Design of Life

    CERN Document Server

    Faller, Roland; Risbud, Subhash H; Jue, Thomas

    2009-01-01

    HANDBOOK OF MODERN BIOPHYSICS Series Editor Thomas Jue, PhD Handbook of Modern Biophysics brings current biophysics topics into focus, so that biology, medical, engineering, mathematics, and physical-science students or researchers can learn fundamental concepts and the application of new techniques in addressing biomedical challenges. Chapters explicate the conceptual framework of the physics formalism and illustrate the biomedical applications. With the addition of problem sets, guides to further study, and references, the interested reader can continue to explore independently the ideas presented. Volume II: Biomembrane Frontiers: Nanostructures, Models, and the Design of Life Editors: Roland Faller, PhD, Thomas Jue, PhD, Marjorie L. Longo, PhD, and Subhash H. Risbud, PhD In Biomembrane Frontiers: Nanostructures, Models, and the Design of Life, prominent researchers have established a foundation for the study of biophysics related to the following topics: Perspectives: Complexes in Liquids, 1900–2008 Mol...

  5. Conceptual study of advanced PWR core design

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Jin; Chang, Moon Hee; Kim, Keung Ku; Joo, Hyung Kuk; Kim, Young Il; Noh, Jae Man; Hwang, Dae Hyun; Kim, Taek Kyum; Yoo, Yon Jong

    1997-09-01

    The purpose of this project is for developing and verifying the core design concepts with enhanced safety and economy, and associated methodologies for core analyses. From the study of the sate-of-art of foreign advanced reactor cores, we developed core concepts such as soluble boron free, high convertible and enhanced safety core loaded semi-tight lattice hexagonal fuel assemblies. To analyze this hexagonal core, we have developed and verified some neutronic and T/H analysis methodologies. HELIOS code was adopted as the assembly code and HEXFEM code was developed for hexagonal core analysis. Based on experimental data in hexagonal lattices and the COBRA-IV-I code, we developed a thermal-hydraulic analysis code for hexagonal lattices. Using the core analysis code systems developed in this project, we designed a 600 MWe core and studied the feasibility of the core concepts. Two additional scopes were performed in this project : study on the operational strategies of soluble boron free core and conceptual design of large scale passive core. By using the axial BP zoning concept and suitable design of control rods, this project showed that it was possible to design a soluble boron free core in 600 MWe PWR. The results of large scale core design showed that passive concepts and daily load follow operation could be practiced. (author). 15 refs., 52 tabs., 101 figs.

  6. Autonomous underwater vehicles modeling, control design and simulation

    CERN Document Server

    Wadoo, Sabiha

    2010-01-01

    Underwater vehicles present some difficult and very particular control system design problems. These are often the result of nonlinear dynamics and uncertain models, as well as the presence of sometimes unforeseeable environmental disturbances that are difficult to measure or estimate. Autonomous Underwater Vehicles: Modeling, Control Design, and Simulation outlines a novel approach to help readers develop models to simulate feedback controllers for motion planning and design. The book combines useful information on both kinematic and dynamic nonlinear feedback control models, providing simula

  7. Designing for Learning and Play - The Smiley Model as Framework

    DEFF Research Database (Denmark)

    Weitze, Charlotte Lærke

    2016-01-01

    This paper presents a framework for designing engaging learning experiences in games – the Smiley Model. In this Design-Based Research project, student-game-designers were learning inside a gamified learning design - while designing and implementing learning goals from curriculum into the small...... digital games. The Smiley Model inspired and provided a scaffold or a heuristic for the overall gamified learning design –- as well as for the students’ learning game design processes when creating small games turning the learning situation into an engaging experience. The audience for the experiments...

  8. Using the ARCS Model To Design Multimedia College Engineering Courses.

    Science.gov (United States)

    Shellnut, Bonnie; Savage, Timothy; Knowlton, Allie

    This paper describes how a Wayne State University (Michigan) multimedia design team is applying Keller's ARCS (Attention, Relevance, Confidence, and Satisfaction) Model of Motivational Design to the entire process of design, development, and evaluation of multimedia courseware. The ARCS Model has been applied to the prototype module and is being…

  9. New experimental model design for VAPEX process experiments

    Energy Technology Data Exchange (ETDEWEB)

    Yazdani, J.A.; Maini, B.B. [Calgary Univ., AB (Canada)

    2004-07-01

    The vast resources of heavy oil and bitumen deposits in Venezuela and Canada have become targets for finding less costly and more effective hydrocarbon recovery methods. Solvent extraction of heavy deposits is an attractive option that is gaining much attention as an in-situ recovery method. Vapour extraction (VAPEX) is analogous to the steam assisted gravity drainage (SAGD) process for the recovery of heavy oil and tar sand reservoirs. However, in VAPEX, vaporized solvents are used instead of high temperature steam and the viscosity of the oil is reduced in situ. VAPEX is particularly suited for formations that are thin and where heat losses are unavoidable. It is also well suited in the presence of overlying gas caps; bottom water aquifers; low thermal conductivity; high water saturation; clay swelling; and, formation damage. Most modelling studies use rectangular shaped models, but these have limitations at high reservoir pressures. This study presents a new design of physical models that overcomes these limitations. The annular space between two cylindrical pipes is used for developing slice-type and sand-filled models. This newly developed model is more compatible with higher pressures. This paper compares results of VAPEX experiments using the cylindrical models and the rectangular models. The stabilized drainage rates from the newly developed cylindrical models are in very good agreement with those from the rectangular models. 16 refs., 3 tabs., 11 figs.

  10. Design, synthesis and molecular modeling studies of few chalcone analogues of benzimidazole for epidermal growth factor receptor inhibitor in search of useful anticancer agent.

    Science.gov (United States)

    Chhajed, Santosh S; Sonawane, Sandeep S; Upasani, Chandrashekhar D; Kshirsagar, Sanjay J; Gupta, Pramodkumar P

    2016-04-01

    In the present investigation, few 3-(substitutedphenyl)-1-[2-(1-hydroxy-ethyl)]-1H-benzimidazol-1-yl)prop-2-en-1-ones are EGFR antagonist are designed, by molecular docking analysis. The synthesized compounds were tested for their in vitro anticancer activity by propidium iodide fluorescent assay and Trypan blue viability assay against colorectal cancer cell lines (HCT116) and non-small cell lung cancer cell lines (H460). Human Epithelial Kidney cell lines (HEK) are used as normal cell lines for studying effect of drug on non-cancerous cells within human body. Evaluation of cytotoxic studies of synthesized compounds CHL(1-8) reveal that compound CHL1 [IC50=7.31 and 10.16 μM against HCT116 and H460 cell lines respectively, by PI assay] and CHL8 [IC50=12.52 and 6.83 against HCT116 and H460μM cell lines respectively] possess promising cytotoxic activity.

  11. Use of advanced modeling techniques to optimize thermal packaging designs.

    Science.gov (United States)

    Formato, Richard M; Potami, Raffaele; Ahmed, Iftekhar

    2010-01-01

    Through a detailed case study the authors demonstrate, for the first time, the capability of using advanced modeling techniques to correctly simulate the transient temperature response of a convective flow-based thermal shipper design. The objective of this case study was to demonstrate that simulation could be utilized to design a 2-inch-wall polyurethane (PUR) shipper to hold its product box temperature between 2 and 8 °C over the prescribed 96-h summer profile (product box is the portion of the shipper that is occupied by the payload). Results obtained from numerical simulation are in excellent agreement with empirical chamber data (within ±1 °C at all times), and geometrical locations of simulation maximum and minimum temperature match well with the corresponding chamber temperature measurements. Furthermore, a control simulation test case was run (results taken from identical product box locations) to compare the coupled conduction-convection model with a conduction-only model, which to date has been the state-of-the-art method. For the conduction-only simulation, all fluid elements were replaced with "solid" elements of identical size and assigned thermal properties of air. While results from the coupled thermal/fluid model closely correlated with the empirical data (±1 °C), the conduction-only model was unable to correctly capture the payload temperature trends, showing a sizeable error compared to empirical values (ΔT > 6 °C). A modeling technique capable of correctly capturing the thermal behavior of passively refrigerated shippers can be used to quickly evaluate and optimize new packaging designs. Such a capability provides a means to reduce the cost and required design time of shippers while simultaneously improving their performance. Another advantage comes from using thermal modeling (assuming a validated model is available) to predict the temperature distribution in a shipper that is exposed to ambient temperatures which were not bracketed

  12. Designing A Mixed Methods Study In Primary Care

    OpenAIRE

    Creswell, John W.; Fetters, Michael D.; Ivankova, Nataliya V.

    2004-01-01

    BACKGROUND Mixed methods or multimethod research holds potential for rigorous, methodologically sound investigations in primary care. The objective of this study was to use criteria from the literature to evaluate 5 mixed methods studies in primary care and to advance 3 models useful for designing such investigations.

  13. Designing A Mixed Methods Study In Primary Care

    OpenAIRE

    Creswell, John W.; Fetters, Michael D.; Ivankova, Nataliya V.

    2004-01-01

    BACKGROUND Mixed methods or multimethod research holds potential for rigorous, methodologically sound investigations in primary care. The objective of this study was to use criteria from the literature to evaluate 5 mixed methods studies in primary care and to advance 3 models useful for designing such investigations.

  14. Designer Modeling for Personalized Game Content Creation Tools

    DEFF Research Database (Denmark)

    Liapis, Antonios; Yannakakis, Georgios N.; Togelius, Julian

    2013-01-01

    With the growing use of automated content creation and computer-aided design tools in game development, there is potential for enhancing the design process through personalized interactions between the software and the game developer. This paper proposes designer modeling for capturing the designer......, and envision future directions which focus on personalizing the processes to a designer’s particular wishes....

  15. Advanced Modeling Concepts for Conceptual Design Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Preliminary design of aircraft structures is multidisciplinary, involving knowledge of structural mechanics, aerodynamics, aeroelasticity, structural dynamics and...

  16. Designing Academic Leadership Minor Programs: Emerging Models

    Science.gov (United States)

    Diallo, Lamine; Gerhardt, Kris

    2017-01-01

    With a growing number of leadership programs in universities and colleges in North America, leadership educators and researchers are engaged in a wide ranging dialogue to propose clear processes, content, and designs for providing academic leadership education. This research analyzes the curriculum design of 52 institutions offering a "Minor…

  17. Designing and Evaluating Representations to Model Pedagogy

    Science.gov (United States)

    Masterman, Elizabeth; Craft, Brock

    2013-01-01

    This article presents the case for a theory-informed approach to designing and evaluating representations for implementation in digital tools to support Learning Design, using the framework of epistemic efficacy as an example. This framework, which is rooted in the literature of cognitive psychology, is operationalised through dimensions of fit…

  18. Tornado risk model for transmission line design

    CSIR Research Space (South Africa)

    Milford, RV

    1997-11-01

    Full Text Available is in combination with ice loading. The wind load used in most codes of practice and design recommendations for transmission line design have until recently been based almost exclusively on large-scale wind storms, which may include severe storms such as hurricanes...

  19. Rapid E-learning Development Strategies and a Multimedia Project Design Model

    Science.gov (United States)

    Sözcü, Ömer Faruk; Ipek, Ismail

    2014-01-01

    The purpose of the study is to discuss e-learning design strategies which can be used for multimedia projects as a design model. Recent advances in instructional technologies have been found to be very important in the design of training courses by using rapid instructional design (ID) approaches. The approaches were developed to use in training…

  20. An Optimal Design Model for New Water Distribution Networks in ...

    African Journals Online (AJOL)

    An Optimal Design Model for New Water Distribution Networks in Kigali City. ... a Linear Programming Problem (LPP) which involves the design of a new network of water distribution considering the cost in the form of unit price ... Article Metrics.

  1. Application of aeroacoustic models to design of wind turbine rotors

    Energy Technology Data Exchange (ETDEWEB)

    Fuglsang, P.; Madsen, H.A. [Risoe National Lab., Wind Energy and Atmospheric Physics Dept., Roskilde (Denmark)

    1997-12-31

    A design method is presented for wind turbine rotors. The design process is split into overall design of the rotor and detailed design of the blade tip. A numerical optimization tool is used together with a semi-empirical noise prediction code for overall rotor design. The noise prediction code is validated with measurements and good agreement is obtained both on the total noise emission and on the sensitivity to wind speed, tip pitch angle and tip speed. A design study for minimum noise emission for a 300 kW rotor shows that the total sound power level can be reduced by 3 dB(A) without loss in energy production and the energy production can be increased by 2% without increase in the total noise. Detailed CFD calculations are subsequently done to resolve the blade tip flow. The characteristics of the general flow and the tip vortex are found, and the relevant parameters for the aeroacoustic models are derived for a sharp rectangular tip. (au) 16 refs.

  2. Neighborhood Design, Physical Activity, and Wellbeing: Applying the Walkability Model.

    Science.gov (United States)

    Zuniga-Teran, Adriana A; Orr, Barron J; Gimblett, Randy H; Chalfoun, Nader V; Guertin, David P; Marsh, Stuart E

    2017-01-13

    Neighborhood design affects lifestyle physical activity, and ultimately human wellbeing. There are, however, a limited number of studies that examine neighborhood design types. In this research, we examine four types of neighborhood designs: traditional development, suburban development, enclosed community, and cluster housing development, and assess their level of walkability and their effects on physical activity and wellbeing. We examine significant associations through a questionnaire (n = 486) distributed in Tucson, Arizona using the Walkability Model. Among the tested neighborhood design types, traditional development showed significant associations and the highest value for walkability, as well as for each of the two types of walking (recreation and transportation) representing physical activity. Suburban development showed significant associations and the highest mean values for mental health and wellbeing. Cluster housing showed significant associations and the highest mean value for social interactions with neighbors and for perceived safety from crime. Enclosed community did not obtain the highest means for any wellbeing benefit. The Walkability Model proved useful in identifying the walkability categories associated with physical activity and perceived crime. For example, the experience category was strongly and inversely associated with perceived crime. This study provides empirical evidence of the importance of including vegetation, particularly trees, throughout neighborhoods in order to increase physical activity and wellbeing. Likewise, the results suggest that regular maintenance is an important strategy to improve mental health and overall wellbeing in cities.

  3. Neighborhood Design, Physical Activity, and Wellbeing: Applying the Walkability Model

    Directory of Open Access Journals (Sweden)

    Adriana A. Zuniga-Teran

    2017-01-01

    Full Text Available Neighborhood design affects lifestyle physical activity, and ultimately human wellbeing. There are, however, a limited number of studies that examine neighborhood design types. In this research, we examine four types of neighborhood designs: traditional development, suburban development, enclosed community, and cluster housing development, and assess their level of walkability and their effects on physical activity and wellbeing. We examine significant associations through a questionnaire (n = 486 distributed in Tucson, Arizona using the Walkability Model. Among the tested neighborhood design types, traditional development showed significant associations and the highest value for walkability, as well as for each of the two types of walking (recreation and transportation representing physical activity. Suburban development showed significant associations and the highest mean values for mental health and wellbeing. Cluster housing showed significant associations and the highest mean value for social interactions with neighbors and for perceived safety from crime. Enclosed community did not obtain the highest means for any wellbeing benefit. The Walkability Model proved useful in identifying the walkability categories associated with physical activity and perceived crime. For example, the experience category was strongly and inversely associated with perceived crime. This study provides empirical evidence of the importance of including vegetation, particularly trees, throughout neighborhoods in order to increase physical activity and wellbeing. Likewise, the results suggest that regular maintenance is an important strategy to improve mental health and overall wellbeing in cities.

  4. A decision-making model for engineering designers

    DEFF Research Database (Denmark)

    Ahmed, S.; Hansen, Claus Thorp

    2002-01-01

    This paper describes research that combines the generic decision-making model of Hansen, together with design strategies employed by experienced engineering designers. The relationship between the six decision-making sub-activities and the eight design strategies are examined. By combining these ...... these two understandings of the design process, a model has been developed, which describes the different types of decision made during the design process together with strategies that aid the designer in making decisions.......This paper describes research that combines the generic decision-making model of Hansen, together with design strategies employed by experienced engineering designers. The relationship between the six decision-making sub-activities and the eight design strategies are examined. By combining...

  5. Integrating Surface Modeling into the Engineering Design Graphics Curriculum

    Science.gov (United States)

    Hartman, Nathan W.

    2006-01-01

    It has been suggested there is a knowledge base that surrounds the use of 3D modeling within the engineering design process and correspondingly within engineering design graphics education. While solid modeling receives a great deal of attention and discussion relative to curriculum efforts, and rightly so, surface modeling is an equally viable 3D…

  6. Integrating Surface Modeling into the Engineering Design Graphics Curriculum

    Science.gov (United States)

    Hartman, Nathan W.

    2006-01-01

    It has been suggested there is a knowledge base that surrounds the use of 3D modeling within the engineering design process and correspondingly within engineering design graphics education. While solid modeling receives a great deal of attention and discussion relative to curriculum efforts, and rightly so, surface modeling is an equally viable 3D…

  7. Design methods for some dose-response models

    NARCIS (Netherlands)

    Albers, Willem/Wim; Strijbosch, Leo W.G.; Does, Ronald J.M.M.

    1990-01-01

    A recently described design method for one-parameter biomedical models such as limiting or serial dilution assays is generalized to two-parameter models for which the dose-response relationship can be expressed as a linear regression model with parameters α (intercept) and β (slope). Design formulae

  8. Designing Mechatronic Products - Achieving Integration by Means of Modelling Dependencies

    DEFF Research Database (Denmark)

    Torry-Smith, Jonas

    The research carried out in this PhD thesis focuses on the integration phenomenon in the design of mechatronic products. It contributes to the understanding of the phenomenon and to conceptual modelling of mechatronic products. These products are perceived to have emerged as a consequence...... to be aware of when designing mechatronic products. The literature study shows that such a classification has not been attempted before. Without a classification to provide a basis for a structured search it is left to chance for the development team to discover potentially critical dependencies in due time....... A ‘Mechatronic Integration Concept’ is proposed aiming at operationalizing the use of the classification. The purpose is to facilitate discussions between engineers from different disciplines on matters that are important to clarify between the designers working on contributing with solutions to the product...

  9. Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model.

    Science.gov (United States)

    Grace, Peter M; Hurley, Daniel; Barratt, Daniel T; Tsykin, Anna; Watkins, Linda R; Rolan, Paul E; Hutchinson, Mark R

    2012-09-01

    A quantitative, peripherally accessible biomarker for neuropathic pain has great potential to improve clinical outcomes. Based on the premise that peripheral and central immunity contribute to neuropathic pain mechanisms, we hypothesized that biomarkers could be identified from the whole blood of adult male rats, by integrating graded chronic constriction injury (CCI), ipsilateral lumbar dorsal quadrant (iLDQ) and whole blood transcriptomes, and pathway analysis with pain behavior. Correlational bioinformatics identified a range of putative biomarker genes for allodynia intensity, many encoding for proteins with a recognized role in immune/nociceptive mechanisms. A selection of these genes was validated in a separate replication study. Pathway analysis of the iLDQ transcriptome identified Fcγ and Fcε signaling pathways, among others. This study is the first to employ the whole blood transcriptome to identify pain biomarker panels. The novel correlational bioinformatics, developed here, selected such putative biomarkers based on a correlation with pain behavior and formation of signaling pathways with iLDQ genes. Future studies may demonstrate the predictive ability of these biomarker genes across other models and additional variables. © 2012 The Authors. Journal of Neurochemistry © 2012 International Society for Neurochemistry.

  10. Harnessing pain heterogeneity and RNA transcriptome to identify blood–based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model

    Science.gov (United States)

    Grace, Peter M.; Hurley, Daniel; Barratt, Daniel T.; Tsykin, Anna; Watkins, Linda R.; Rolan, Paul E.; Hutchinson, Mark R.

    2017-01-01

    A quantitative, peripherally accessible biomarker for neuropathic pain has great potential to improve clinical outcomes. Based on the premise that peripheral and central immunity contribute to neuropathic pain mechanisms, we hypothesized that biomarkers could be identified from the whole blood of adult male rats, by integrating graded chronic constriction injury (CCI), ipsilateral lumbar dorsal quadrant (iLDQ) and whole blood transcriptomes, and pathway analysis with pain behavior. Correlational bioinformatics identified a range of putative biomarker genes for allodynia intensity, many encoding for proteins with a recognized role in immune/nociceptive mechanisms. A selection of these genes was validated in a separate replication study. Pathway analysis of the iLDQ transcriptome identified Fcγ and Fcε signaling pathways, among others. This study is the first to employ the whole blood transcriptome to identify pain biomarker panels. The novel correlational bioinformatics, developed here, selected such putative biomarkers based on a correlation with pain behavior and formation of signaling pathways with iLDQ genes. Future studies may demonstrate the predictive ability of these biomarker genes across other models and additional variables. PMID:22697386

  11. Perceiving design as modelling: A cybernetic systems perspective

    DEFF Research Database (Denmark)

    Maier, Anja; Wynn, David C.; Howard, Thomas J.;

    2014-01-01

    this chapter). Given this, how should design activities be co-ordinated and how should the design process be regulated? This chapter suggests that a cybernetic perspective may help to understand designing as a self-regulated modelling system and help to reach a better understanding of the effectiveness...... out to add value for a given purpose and context. Implications of a cybernetic perspective that could guide effective modelling in design are discussed....

  12. Irregular Shaped Building Design Optimization with Building Information Modelling

    Directory of Open Access Journals (Sweden)

    Lee Xia Sheng

    2016-01-01

    Full Text Available This research is to recognise the function of Building Information Modelling (BIM in design optimization for irregular shaped buildings. The study focuses on a conceptual irregular shaped “twisted” building design similar to some existing sculpture-like architectures. Form and function are the two most important aspects of new buildings, which are becoming more sophisticated as parts of equally sophisticated “systems” that we are living in. Nowadays, it is common to have irregular shaped or sculpture-like buildings which are very different when compared to regular buildings. Construction industry stakeholders are facing stiff challenges in many aspects such as buildability, cost effectiveness, delivery time and facility management when dealing with irregular shaped building projects. Building Information Modelling (BIM is being utilized to enable architects, engineers and constructors to gain improved visualization for irregular shaped buildings; this has a purpose of identifying critical issues before initiating physical construction work. In this study, three variations of design options differing in rotating angle: 30 degrees, 60 degrees and 90 degrees are created to conduct quantifiable comparisons. Discussions are focused on three major aspects including structural planning, usable building space, and structural constructability. This research concludes that Building Information Modelling is instrumental in facilitating design optimization for irregular shaped building. In the process of comparing different design variations, instead of just giving “yes or no” type of response, stakeholders can now easily visualize, evaluate and decide to achieve the right balance based on their own criteria. Therefore, construction project stakeholders are empowered with superior evaluation and decision making capability.

  13. Design and modeling balloon-expandable coronary stent for manufacturability

    Science.gov (United States)

    Suryawan, D.; Suyitno

    2017-02-01

    Coronary artery disease (CAD) is a disease that caused by narrowing of the coronary artery. The narrowing coronary artery is usually caused by cholesterol-containing deposit (plaque) which can cause a heart attack. CAD is the most common cause mortality in Indonesia. The commonly CAD treatment use the stent to opens or alleviate the narrowing coronary artery. In this study, the stent design is optimized for the manufacturability. Modeling is used to determine the free stent expansion due to applied pressure in the inner surface of the stent. The stress distribution, outer diameter change, and dogboning phenomena are investigated in the simulation. The result of modeling and simulating was analyzed and used to optimize the stent design before it is manufactured using EDM (Electric Discharge Machine) in the next research.

  14. Parametric design of the Vela roof: A case study on performance oriented exploration of design alternatives

    NARCIS (Netherlands)

    Turrin, M.; Stouffs, R.M.F.; Sariyildiz, I.S.

    2010-01-01

    The paper presents a case study, in which parametric modeling has been used to explore the geometrical design alternatives of a large span roof. Explorative criteria are oriented to the use of on site energy resources, with specific focus on the mitigation of summer discomfort. After broadly

  15. Design and Modelling of Small Scale Low Temperature Power Cycles

    DEFF Research Database (Denmark)

    Wronski, Jorrit

    impact on the work output of the expander.The final part of this report deals with the performance of plate heat exchangers. Several plate heat exchanger correlations were reviewed focussing on their applicability to ORC systems. A framework for dynamic heat exchanger modelling was developed......he work presented in this report contributes to the state of the art within design and modelling of small scale low temperature power cycles. The study is divided into three main parts: (i) fluid property evaluation, (ii) expansion device investigations and (iii) heat exchanger performance...... times and below 10−7 away from the phase boundaries.Regarding expansion devices for small scale organic Rankine cycle (ORC) systems,this work focussed on reciprocating machines. A prototype of a reciprocating expander with a swept volume of 736 cm3 was tested and modelled. he model was written in object...

  16. Algorithms of D-optimal designs for Morgan Mercer Flodin (MMF) models with three parameters

    Science.gov (United States)

    Widiharih, Tatik; Haryatmi, Sri; Gunardi, Wilandari, Yuciana

    2016-02-01

    Morgan Mercer Flodin (MMF) model is used in many areas including biological growth studies, animal and husbandry, chemistry, finance, pharmacokinetics and pharmacodynamics. Locally D-optimal designs for Morgan Mercer Flodin (MMF) models with three parameters are investigated. We used the Generalized Equivalence Theorem of Kiefer and Wolvowitz to determine D-optimality criteria. Number of roots for standardized variance are determined using Tchebysheff system concept and it is used to decide that the design is minimally supported design. In these models, designs are minimally supported designs with uniform weight on its support, and the upper bound of the design region is a support point.

  17. Research study on IPS digital controller design

    Science.gov (United States)

    Kuo, B. C.; Folkerts, C.

    1976-01-01

    The performance is investigated of the simplified continuous-data model of the Instrument Pointing System (IPS). Although the ultimate objective is to study the digital model of the system, knowledge on the performance of the continuous-data model is important in the sense that the characteristics of the digital system should approach those of the continuous-data system as the sampling period approaches zero.

  18. Robust and efficient designs for the Michaelis-Menten model

    OpenAIRE

    Dette, Holger; Biedermann, Stefanie

    2002-01-01

    For the Michaelis-Menten model, we determine designs that maximize the minimum of the D-efficiencies over a certain interval for the nonlinear parameter. The best two point designs can be found explicitly, and a characterization is given when these designs are optimal within the class of all designs. In most cases of practical interest, the determined designs are highly efficient and robust with respect to misspecification of the nonlinear parameter. The results are illustrated and applied in...

  19. Large scale solar district heating. Evaluation, modelling and designing

    Energy Technology Data Exchange (ETDEWEB)

    Heller, A.

    2000-07-01

    The main objective of the research was to evaluate large-scale solar heating connected to district heating (CSDHP), to build up a simulation tool and to demonstrate the application of the tool for design studies and on a local energy planning case. The evaluation of the central solar heating technology is based on measurements on the case plant in Marstal, Denmark, and on published and unpublished data for other, mainly Danish, CSDHP plants. Evaluations on the thermal, economical and environmental performances are reported, based on the experiences from the last decade. The measurements from the Marstal case are analysed, experiences extracted and minor improvements to the plant design proposed. For the detailed designing and energy planning of CSDHPs, a computer simulation model is developed and validated on the measurements from the Marstal case. The final model is then generalised to a 'generic' model for CSDHPs in general. The meteorological reference data, Danish Reference Year, is applied to find the mean performance for the plant designs. To find the expectable variety of the thermal performance of such plants, a method is proposed where data from a year with poor solar irradiation and a year with strong solar irradiation are applied. Equipped with a simulation tool design studies are carried out spreading from parameter analysis over energy planning for a new settlement to a proposal for the combination of plane solar collectors with high performance solar collectors, exemplified by a trough solar collector. The methodology of utilising computer simulation proved to be a cheap and relevant tool in the design of future solar heating plants. The thesis also exposed the demand for developing computer models for the more advanced solar collector designs and especially for the control operation of CSHPs. In the final chapter the CSHP technology is put into perspective with respect to other possible technologies to find the relevance of the application

  20. Hovercraft telemanipulation virtual models and interface design

    OpenAIRE

    Noronha, Hildegardo José Quintal

    2013-01-01

    A control system was designed to allow humans to manually drive an, usually automatic, two wheeled hovercraft. The size, the mass and the way of driving this vehicle proves to be an issue for the everyday, untrained person to achieve. During this thesis several control layouts were designed with the objective of creating an intuitive and easy way of driving such a vehicle. At the end two where usertested using a simulation (also developed during this thesis) of the said hovercr...

  1. Hovercraft telemanipulation virtual models and interface design

    OpenAIRE

    Noronha, Hildegardo José Quintal

    2013-01-01

    A control system was designed to allow humans to manually drive an, usually automatic, two wheeled hovercraft. The size, the mass and the way of driving this vehicle proves to be an issue for the everyday, untrained person to achieve. During this thesis several control layouts were designed with the objective of creating an intuitive and easy way of driving such a vehicle. At the end two where usertested using a simulation (also developed during this thesis) of the said hovercr...

  2. Deepening Kindergarteners' Science Vocabulary: A Design Study

    Science.gov (United States)

    Parsons, Allison Ward; Bryant, Camille Lawrence

    2016-01-01

    Early, effective instruction to introduce both science vocabulary and general academic language may help children build a strong conceptual and linguistic foundation for later instruction. In this study, a design research intervention was employed to expose children to a variety of interrelated science content words to increase both the breadth…

  3. Study designs for PDSA quality improvement research.

    Science.gov (United States)

    Speroff, Theodore; O'Connor, Gerald T

    2004-01-01

    The purpose of this article is to discuss strengths and weaknesses of quasi-experimental designs used in health care quality improvement research. The target groups for this article are investigators in plan-do-study-act (PDSA) quality improvement initiatives who wish to improve the rigor of their methodology and publish their work and reviewers who evaluate the quality of research proposals or published work. A primary purpose of PDSA quality improvement research is to establish a functional relationship between process changes in systems of health care and variation in outcomes. The time series design is the fundamental paradigm for demonstrating such functional relationships. The rigor of a PDSA quality improvement study design is strengthened using replication schemes and research methodology to address extraneous factors that weaken validity of observational studies. The design of PDSA quality improvement research should follow from the purpose and context of the project. Improving the rigor of the quality improvement literature will build a stronger foundation and more convincing justification for the study and practice of quality improvement in health care.

  4. Study on the Effect Mechanism of Business Model Design on Start-ups' Performance%商业模式设计对新创企业绩效的影响机制研究

    Institute of Scientific and Technical Information of China (English)

    张郑熠; 金珺; 陈俊滢; 郭敏

    2015-01-01

    The paper focuses on the relationship between the start-ups' model design and their performance. At the same time, the paper argues that situational factors such as environment munificence and absorption ability have a moderating effect on the relationship between business model design and performance. For this purpose, this study tests such relationship using the method of OLS on the basis of survey data from 115 start-ups questionnaires. Results show that novelty-centered business model design has positive effect on performance significantly, while the effect of efficiency-centered business model design on performance is not significant. In addition, environment munificence positively moderates the relationship between novelty-centered business model design and performance, and the absorptive capacity also positively moderates the relationship between novelty-centered business model design and performance.%本文聚焦于新创企业的商业模式设计同其绩效之间的关系,并考虑情境因素如环境友善性和吸收能力对商业模式设计与新创企业绩效关系的调节作用.为此,本研究在对 115 家新创企业问卷调查数据的基础上,采用OLS方法对相关关系进行了检验.结果表明,新创企业的新颖型商业模式设计正向影响企业绩效,而效率型商业模式设计的影响不显著,而且环境友善性正向调节新颖型商业模式设计与新创企业绩效的关系;吸收能力正向调节新颖型商业模式设计与新创企业绩效关系.

  5. Designing experiments to discriminate families of logic models

    Directory of Open Access Journals (Sweden)

    Santiago eVidela

    2015-09-01

    Full Text Available Logic models of signaling pathways are a promising way of building effective in silico functional models of a cell, in particular of signaling pathways. The automated learning of Boolean logic models describing signaling pathways can be achieved by training to phosphoproteomics data, which is particularly useful if it is measured upon different combinations of perturbations in a high-throughput fashion. However, in practice the number and type of allowed perturbations is not exhaustive. Moreover, experimental data is unavoidably subject to noise. As a result, the learning process results in a family of feasible logical networks rather than in a single model. This family is composed of logic models implementing different internal wirings for the system and therefore the predictions of experiments from this family may present a significant level of variability, and hence uncertainty.In this paper, we introduce a method based on Answer Set Programming to propose an optimal experimental design that aims to narrow down the variability (in terms of input-output behaviors within families of logical models learned from experimental data. We study how the fitness with respect to the data can be improved after an optimal selection of signaling perturbations and how we learn optimal logic models with minimal number of experiments. The methods are applied on signaling pathways in human liver cells and phosphoproteomics experimental data. Using 25% of the experiments we obtained logical models with fitness scores (mean square error 15% close to the ones obtained using all experiments, illustrating the impact that our approach can have on the design of experiments for efficient model calibration.

  6. The Use of Engineering Design Concept for Computer Programming Course: A Model of Blended Learning Environment

    Science.gov (United States)

    Tritrakan, Kasame; Kidrakarn, Pachoen; Asanok, Manit

    2016-01-01

    The aim of this research is to develop a learning model which blends factors from learning environment and engineering design concept for learning in computer programming course. The usage of the model was also analyzed. This study presents the design, implementation, and evaluation of the model. The research methodology is divided into three…

  7. AN INSTRUCTIONAL DESIGN MODEL FOR BLENDED HIGHER EDUCATION

    Directory of Open Access Journals (Sweden)

    George Hack

    2016-07-01

    Full Text Available Instructional design models that are used by many higher education institutions to guide course design are insufficient for the unique opportunities of blended learning. Many established models are not practical tools for college faculty to use independently in the design of courses. Models like A.D.D.I.E., use a linear approach that can translate more easily into practical stages of course design, yet are historically rooted in the rapid prototyping of educational technologies or for designing military training and are inadequate for the complex demands of higher education, where learning outcomes are geared toward higher order thinking, scientific/clinical reasoning, and a syntheses of ideas into new knowledge. Presented here is an instructional design model that strategically incorporates the nuances of higher education, yet is practically framed to assist faculty with design challenges.

  8. Simple Models Create Steep Learning Curves in Academic Design Studio

    DEFF Research Database (Denmark)

    Hansen, Peter Lundsgaard; Dam, Torben; Le Goffic, Virginie Corinne

    2014-01-01

    This paper presents an easily adaptable, very learning-efficient and solution-oriented design studio method: ‘the simple model method’. On a practical level it solves well known problems that occur when teaching design studios. On a theoretical level it suggests a ‘third way’ of bridging design......, their supervisors and other actors. The simple model is a non-verbal agent. However, due to its simplicity it enables verbalization supporting a solution-focused design studio teaching strategy. The simple model method is presented through a specific design studio course undertaken at the University of Copenhagen...... theory positions normally regarded as mutually incompatible. The method is the result of years of ‘trial and error’ design studio teaching at the University of Copenhagen, triangulated with academic design theory research. Research based design studio teaching poses a fundamental pedagogical challenge...

  9. Mining Domain-Specific Design Patterns: A Case Study

    Directory of Open Access Journals (Sweden)

    Vassiliki Gkantouna

    2017-02-01

    Full Text Available Domain-specific design patterns provide developers with proven solutions to common design problems that arise, particularly in a target application domain, facilitating them to produce quality designs in the domain contexts. However, research in this area is not mature and there are no techniques to support their detection. Towards this end, we propose a methodology which, when applied on a collection of websites in a specific domain, facilitates the automated identification of domain-specific design patterns. The methodology automatically extracts the conceptual models of the websites, which are subsequently analyzed in terms of all of the reusable design fragments used in them for supporting common domain functionalities. At the conceptual level, we consider these fragments as recurrent patterns consisting of a configuration of front-end interface components that interrelate each other and interact with end-users to support certain functionality. By performing a pattern-based analysis of the models, we locate the occurrences of all the recurrent patterns in the various website designs which are then evaluated towards their consistent use. The detected patterns can be used as building blocks in future designs, assisting developers to produce consistent and quality designs in the target domain. To support our case, we present a case study for the educational domain.

  10. Business model design for a wearable biofeedback system.

    Science.gov (United States)

    Hidefjäll, Patrik; Titkova, Dina

    2015-01-01

    Wearable sensor technologies used to track daily activities have become successful in the consumer market. In order for wearable sensor technology to offer added value in the more challenging areas of stress-rehab care and occupational health stress-related biofeedback parameters need to be monitored and more elaborate business models are needed. To identify probable success factors for a wearable biofeedback system (Affective Health) in the two mentioned market segments in a Swedish setting, we conducted literature studies and interviews with relevant representatives. Data were collected and used first to describe the two market segments and then to define likely feasible business model designs, according to the Business Model Canvas framework. Needs of stakeholders were identified as inputs to business model design. Value propositions, a key building block of a business model, were defined for each segment. The value proposition for occupational health was defined as "A tool that can both identify employees at risk of stress-related disorders and reinforce healthy sustainable behavior" and for healthcare as: "Providing therapists with objective data about the patient's emotional state and motivating patients to better engage in the treatment process".

  11. PARAMETRIC MODELING, CREATIVITY, AND DESIGN: TWO EXPERIENCES WITH ARCHITECTURE’ STUDENTS

    Directory of Open Access Journals (Sweden)

    Wilson Florio

    2012-02-01

    Full Text Available The aim of this article is to reflect on the use of the parametric modeling in two didactic experiences. The first experiment involved resources of the Paracloud program and its relation with the Rhinoceros program, that resulted in the production of physical models produced with the aid of the laser cutting. In the second experiment, the students had produced algorithms in the Grasshopper, resulting in families of structures and coverings. The study objects are both the physical models and digital algorithms resultants from this experimentation. For the analysis and synthesis of the results, we adopted four important assumptions: 1. the value of attitudes and environment of work; 2. the importance of experimentation and improvisation; 3. understanding of the design process as a situated act and as a ill-defined problem; 4. the inclusion of creative and critical thought in the disciplines. The results allow us to affirm that the parametric modeling stimulates creativity, therefore allowing combination of different parameters, that result in unexpected discoveries. Keywords: Teach-Learning, Parametric Modeling, Laser Cutter, Grasshopper, Design Process, Creativity.

  12. Thermodynamic Studies for Drug Design and Screening

    Science.gov (United States)

    Garbett, Nichola C.; Chaires, Jonathan B.

    2012-01-01

    Introduction A key part of drug design and development is the optimization of molecular interactions between an engineered drug candidate and its binding target. Thermodynamic characterization provides information about the balance of energetic forces driving binding interactions and is essential for understanding and optimizing molecular interactions. Areas covered This review discusses the information that can be obtained from thermodynamic measurements and how this can be applied to the drug development process. Current approaches for the measurement and optimization of thermodynamic parameters are presented, specifically higher throughput and calorimetric methods. Relevant literature for this review was identified in part by bibliographic searches for the period 2004 – 2011 using the Science Citation Index and PUBMED and the keywords listed below. Expert opinion The most effective drug design and development platform comes from an integrated process utilizing all available information from structural, thermodynamic and biological studies. Continuing evolution in our understanding of the energetic basis of molecular interactions and advances in thermodynamic methods for widespread application are essential to realize the goal of thermodynamically-driven drug design. Comprehensive thermodynamic evaluation is vital early in the drug development process to speed drug development towards an optimal energetic interaction profile while retaining good pharmacological properties. Practical thermodynamic approaches, such as enthalpic optimization, thermodynamic optimization plots and the enthalpic efficiency index, have now matured to provide proven utility in design process. Improved throughput in calorimetric methods remains essential for even greater integration of thermodynamics into drug design. PMID:22458502

  13. Modelling and Design of a Microstrip Band-Pass Filter Using Space Mapping Techniques

    CERN Document Server

    Tavakoli, Saeed; Mohanna, Shahram

    2010-01-01

    Determination of design parameters based on electromagnetic simulations of microwave circuits is an iterative and often time-consuming procedure. Space mapping is a powerful technique to optimize such complex models by efficiently substituting accurate but expensive electromagnetic models, fine models, with fast and approximate models, coarse models. In this paper, we apply two space mapping, an explicit space mapping as well as an implicit and response residual space mapping, techniques to a case study application, a microstrip band-pass filter. First, we model the case study application and optimize its design parameters, using explicit space mapping modelling approach. Then, we use implicit and response residual space mapping approach to optimize the filter's design parameters. Finally, the performance of each design methods is evaluated. It is shown that the use of above-mentioned techniques leads to achieving satisfactory design solutions with a minimum number of computationally expensive fine model eval...

  14. Architecture design in global and model-centric software development

    NARCIS (Netherlands)

    Heijstek, Werner

    2012-01-01

    This doctoral dissertation describes a series of empirical investigations into representation, dissemination and coordination of software architecture design in the context of global software development. A particular focus is placed on model-centric and model-driven software development.

  15. Architecture design in global and model-centric software development

    NARCIS (Netherlands)

    Heijstek, Werner

    2012-01-01

    This doctoral dissertation describes a series of empirical investigations into representation, dissemination and coordination of software architecture design in the context of global software development. A particular focus is placed on model-centric and model-driven software development.

  16. Design developing conceptual models blade with geometric combined surface

    OpenAIRE

    Juraev, T. H.; Bukhara Technological Institute of Engineering, Bukhara

    2013-01-01

    A conceptual model of the blade using the methods of geometricmodeling principles of industrial design and CAD technologies. Variants are functional use of the proposed model for various working bodies.

  17. Triazole linked mono carbonyl curcumin-isatin bifunctional hybrids as novel anti tubulin agents: Design, synthesis, biological evaluation and molecular modeling studies.

    Science.gov (United States)

    Sharma, Sahil; Gupta, Manish K; Saxena, Ajit K; Bedi, Preet Mohinder S

    2015-11-15

    Keeping in view the limitations associated with currently available anticancer drugs, molecular hybrids of mono carbonyl curcumin and isatin tethered by triazole ring have been synthesized and evaluated for in vitro cytotoxicity against THP-1, COLO-205, HCT-116, A549, HeLa, CAKI-I, PC-3, MiaPaca-2 human cancer cell lines. The results revealed that the compounds SA-1 to SA-9, SB-2, SB-3, SB-4, SB-7 and SC-2 showed a good range of IC50 values against THP-1, COLO-205, HCT-116 and PC-3 cell lines, while the other four cell lines among these were found to be almost resistant. Structure activity relationship revealed that the nature of Ring X and substitution at position R influences the activity. Methoxy substituted phenyl ring as Ring X and H as R were found to be the ideal structural features. The most potent compounds (SA-2, SA-3, SA-4, SA-7) were further tested for tubulin inhibition. Compound SA-2 was found to significantly inhibit the tubulin polymerization (IC50=1.2 μM against HCT-116). Compound SA-2, moreover, lead to the disruption of microtubules as confirmed by immunofluorescence technique. The significant cytotoxicity and tubulin inhibition by SA-2 was streamlined by molecular modeling studies where it was docked at the curcumin binding site of tubulin.

  18. Design, modeling and simulation of MEMS-based silicon Microneedles

    Science.gov (United States)

    Amin, F.; Ahmed, S.

    2013-06-01

    The advancement in semiconductor process engineering and nano-scale fabrication technology has made it convenient to transport specific biological fluid into or out of human skin with minimum discomfort. Fluid transdermal delivery systems such as Microneedle arrays are one such emerging and exciting Micro-Electro Mechanical System (MEMS) application which could lead to a total painless fluid delivery into skin with controllability and desirable yield. In this study, we aimed to revisit the problem with modeling, design and simulations carried out for MEMS based silicon hollow out of plane microneedle arrays for biomedical applications particularly for transdermal drug delivery. An approximate 200 μm length of microneedle with 40 μm diameter of lumen has been successfully shown formed by isotropic and anisotropic etching techniques using MEMS Pro design tool. These microneedles are arranged in size of 2 × 4 matrix array with center to center spacing of 750 μm. Furthermore, comparisons for fluid flow characteristics through these microneedle channels have been modeled with and without the contribution of the gravitational forces using mathematical models derived from Bernoulli Equation. Physical Process simulations have also been performed on TCAD SILVACO to optimize the design of these microneedles aligned with the standard Si-Fabrication lines.

  19. Structural Design of Oligopeptides for Intestinal Transport Model.

    Science.gov (United States)

    Hong, Seong-Min; Tanaka, Mitsuru; Koyanagi, Riho; Shen, Weilin; Matsui, Toshiro

    2016-03-16

    Glycyl-sarcosine (Gly-Sar) is a well-known model substrate for the intestinal uptake of dipeptides through peptide transporter 1 (PepT1). However, there are no other model peptides larger than tripeptides to evaluate their intestinal transport ability. In this study, we designed new oligopeptides based on the Gly-Sar structure in terms of protease resistance. Gly-Sar-Sar was found to be an appropriate transport model for tripeptides because it does not degrade during the transport across the rat intestinal membrane, while Gly-Gly-Sar was degraded to Gly-Sar during the 60 min transport. Caco-2 cell transport experiments revealed that the designed oligopeptides based on Gly-Sar-Sar showed a significantly (p transport ability by factors of 1/10-, 1/25-, and 1/40-fold for Gly-Sar-Sar, Gly-Sar-Sar-Sar, and Gly-Sar-Sar-Sar-Sar, respectively, compared to Gly-Sar (apparent permeability coefficient: 38.6 ± 11.4 cm/s). Cell experiments also showed that the designed tripeptide and Gly-Sar were transported across Caco-2 cell via PepT1, whereas the tetra- and pentapeptides were transported through the paracellular tight-junction pathway.

  20. Development Design Model of Academic Quality Assurance at Private Islamic University Jakarta Indonesia

    Science.gov (United States)

    Suprihatin, Krebet; Bin Mohamad Yusof, Hj. Abdul Raheem

    2015-01-01

    This study aims to evaluate the practice of academic quality assurance in design model based on seven aspects of quality are: curriculum design, teaching and learning, student assessment, student selection, support services, learning resources, and continuous improvement. The design study was conducted in two stages. The first stage is to obtain…

  1. Integrating 3D modeling, photogrammetry and design

    CERN Document Server

    Foster, Shaun

    2014-01-01

    This book looks at the convergent nature of technology and its relationship to the field of photogrammetry and 3D design. This is a facet of a broader discussion of the nature of technology itself and the relationship of technology to art, as well as an examination of the educational process. In the field of technology-influenced design-based education it is natural to push for advanced technology, yet within a larger institution the constraints of budget and adherence to tradition must be accepted. These opposing forces create a natural balance; in some cases constraints lead to greater creat

  2. An uncertain multidisciplinary design optimization method using interval convex models

    Science.gov (United States)

    Li, Fangyi; Luo, Zhen; Sun, Guangyong; Zhang, Nong

    2013-06-01

    This article proposes an uncertain multi-objective multidisciplinary design optimization methodology, which employs the interval model to represent the uncertainties of uncertain-but-bounded parameters. The interval number programming method is applied to transform each uncertain objective function into two deterministic objective functions, and a satisfaction degree of intervals is used to convert both the uncertain inequality and equality constraints to deterministic inequality constraints. In doing so, an unconstrained deterministic optimization problem will be constructed in association with the penalty function method. The design will be finally formulated as a nested three-loop optimization, a class of highly challenging problems in the area of engineering design optimization. An advanced hierarchical optimization scheme is developed to solve the proposed optimization problem based on the multidisciplinary feasible strategy, which is a well-studied method able to reduce the dimensions of multidisciplinary design optimization problems by using the design variables as independent optimization variables. In the hierarchical optimization system, the non-dominated sorting genetic algorithm II, sequential quadratic programming method and Gauss-Seidel iterative approach are applied to the outer, middle and inner loops of the optimization problem, respectively. Typical numerical examples are used to demonstrate the effectiveness of the proposed methodology.

  3. Statistical approaches to the design of toxicology studies.

    Science.gov (United States)

    Gad, S C

    2001-01-01

    Application of statistics to toxicological studies involves hypothesis testing, model fitting, and reduction of dimensionality. This unit reviews statistical approaches to data (i.e., descriptive statistics, experimental design, outliers and rounding of numbers, and specific applications) and includes a set of decision trees to assist in choosing the appropriate methods.

  4. PECULIARITIES OF CLOTHES MODELLING BY MEANS OF GRAPHIC DESIGN

    Directory of Open Access Journals (Sweden)

    Fatima Mustafa OBARI

    2014-01-01

    Full Text Available The paper examined some aspects of fashion design for garments with application of graphic design software/ facilities. The study focused on the course of designing with the graphics software, creating the dimensional and extensive environment, which influenced the shaping of a garment and alterations to within the scope of current trends in fashion design. The study observed creative sketching and designing tasks, a designed shape, an artist vision of the item in the graphic design. The paper showed the course of applying graphic design that con-sisted of four interrelated stages of design performance, i.e. sketchpad work, morphological and function-specific and manufacturing steps of design. The study has shown the specifics of design performance aimed at raising conceptual and technology-related level of awareness required.

  5. Optimal minimax designs over a prespecified interval in a heteroscedastic polynomial model.

    Science.gov (United States)

    Chen, Ray-Bing; Wong, Weng Kee; Li, Kun-Yu

    2008-09-15

    Minimax optimal designs can be useful for estimating response surface but they are notoriously difficult to study analytically. We provide formulae for three types of minimax optimal designs over a user-specified region. We focus on polynomial models with various types of heteroscedastic errors but the design strategy is applicable to other types of linear models and optimality criteria. Relationships among the three types of minimax optimal designs are discussed.

  6. Advanced turbine systems: Studies and conceptual design

    Energy Technology Data Exchange (ETDEWEB)

    van der Linden, S.; Gnaedig, G.; Kreitmeier, F.

    1993-11-01

    The ABB selection for the Advanced Turbine System (ATS) includes advanced developments especially in the hot gas path of the combustion turbine and new state-of-the-art units such as the steam turbine and the HRSG. The increase in efficiency by more than 10% multiplicative compared to current designs will be based on: (1) Turbine Inlet Temperature Increase; (2) New Cooling Techniques for Stationary and Rotating Parts; and New Materials. Present, projected component improvements that will be introduced with the above mentioned issues will yield improved CCSC turbine performance, which will drive the ATS selected gas-fired reference CC power plant to 6 % LHV or better. The decrease in emission levels requires a careful optimization of the cycle design, where cooling air consumption has to be minimized. All interfaces of the individual systems in the complete CC Plant need careful checks, especially to avoid unnecessary margins in the individual designs. This study is an important step pointing out the feasibility of the ATS program with realistic goals set by DOE, which, however, will present challenges for Phase II time schedule of 18 months. With the approach outlined in this study and close cooperation with DOE, ATS program success can be achieved to deliver low emissions and low cost of electricity by the year 2002. The ABB conceptual design and step approach will lead to early component demonstration which will help accelerate the overall program objectives.

  7. Designerly Visualisation: Conceptions, Methods, Models, Perceptions

    NARCIS (Netherlands)

    Breen, J.L.H.

    2013-01-01

    If we wish to reach a deeper, more objective understanding of the phenomena of Architectural and Environmental Design, we need to develop and apply working methods that allow us to imaginatively analyse and consequently envision the formal issues which are at (inter)play: demonstrating their working

  8. A unified modeling framework for service design

    NARCIS (Netherlands)

    Jayasinghe Arachchig, J.

    2013-01-01

    Service-oriented architectures are the upcoming business standard for realizing enterprise information systems, thus creating a need for analysis and design methods that are truly service-oriented. Most research on this topic so far takes a strict software engineering perspective. Separation of the

  9. A unified modeling framework for service design

    NARCIS (Netherlands)

    Jayasinghe Arachchig, J.

    2013-01-01

    Service-oriented architectures are the upcoming business standard for realizing enterprise information systems, thus creating a need for analysis and design methods that are truly service-oriented. Most research on this topic so far takes a strict software engineering perspective. Separation of the

  10. Building performance modelling for sustainable building design

    Directory of Open Access Journals (Sweden)

    Olufolahan Oduyemi

    2016-12-01

    The output revealed that BPM delivers information needed for enhanced design and building performance. Recommendations such as the establishment of proper mechanisms to monitor the performance of BPM related construction are suggested to allow for its continuous implementation. This research consolidates collective movements towards wider implementation of BPM and forms a base for developing a sound BIM strategy and guidance.

  11. CSP Design Model and Tool Support

    NARCIS (Netherlands)

    Volkerink, H.J.; Volkerink, H.J.; Hilderink, G.H.; Broenink, Johannes F.; Vervoort, Wiek; Welch, P.H.; Bakkers, André

    The CSP paradigm is known as a powerful concept for designing and analysing the architectural and behavioural parts of concurrent software. Although the theory of CSP is useful for mathematicians, the programming language occam has been derived from CSP that is useful for any engineering practice.

  12. CSP design model and tool support

    NARCIS (Netherlands)

    Volkerink, H.J.; Hilderink, G.H.; Broenink, J.F.; Vervoort, W.A.; Bakkers, A.W.P.; Welch, P.H.; Bakkers, A.W.P.

    2000-01-01

    The CSP paradigm is known as a powerful concept for designing and analysing the architectural and behavioural parts of concurrent software. Although the theory of CSP is useful for mathematicians, the programming language occam has been derived from CSP that is useful for any engineering practice. N

  13. The study of Parametric Design for Body of Organization based on Skeleton Model by Pro/E%曲柄摇杆机构的骨架模型法参数化设计研究

    Institute of Scientific and Technical Information of China (English)

    李润

    2012-01-01

    The top- down design mode accords with the design process for product. The skeleton model design is one of the method that top - down designs in pro/E. The skeleton model of Pro/E reflects the total structure and design project of product. The skeleton model promises scientific product design and the accuracy of assemble. With Pro/Engineer parametric design, a new method of skeleton model for body of organization is proposed. By skeleton model method, the parts of organization body is designed. The Parametric designs and the series designs is finished with change of the parameter of skeleton model. This system provides a simple and convenient modeling method, which is helpful to improve the designing quality and working efficiency and shorten the design cycle. The model can be applied to other similar parts of the design process.%自顶向下的设计模式符合产品的设计思路,Pro/E软件在组件模式下的骨架模型设计是自顶向下设计的方法之一。该法可以使设计信息在整个组件中顺利地传达,保证了产品设计合理性和装配的准确性,从而确保稳妥的设计。结合Pro/E参数化建模思路,在组件模式下设计了曲柄摇杆机构的参数化骨架模型,并通过该骨架模型创建了机构零件,通过改变机构骨架模型参数,实现了曲柄摇杆机构的参数化和系列化设计。

  14. How to design a financial planning model.

    Science.gov (United States)

    Hayen, R L

    1983-10-01

    Corporate planning models frequently consist of integrated pro forma income statements, statements of financial position, and cashflow statements. When implemented by utilizing computer-based planning systems, these models allow managers to explore potential decisions in 'what if?' planning analyses. The logic of an integrated financial statement planning model can be arranged following either a 'funds needed to balance approach' or a 'direct approach'. With a funds needed to balance approach total assets are set equal to total liabilities plus equities to satisfy this fundamental accounting identity. Logic in such models is often difficult to validate. In the direct approach, total assets are calculated independently of total liabilities plus equities providing an extremely strong test for model validation prior to using the model to assess 'what if' alternatives. In this paper, the author discusses the logic of integrated financial planning models and their implementation with computer-based planning systems. The funds need to balance approach and the direct approach are described and contrasted to assist corporate planners in evaluating and selecting a method for constructing the logic of corporate planning models.

  15. Designing Network-based Business Model Ontology

    DEFF Research Database (Denmark)

    Hashemi Nekoo, Ali Reza; Ashourizadeh, Shayegheh; Zarei, Behrouz

    2015-01-01

    Survival on dynamic environment is not achieved without a map. Scanning and monitoring of the market show business models as a fruitful tool. But scholars believe that old-fashioned business models are dead; as they are not included the effect of internet and network in themselves. This paper...... is going to propose e-business model ontology from the network point of view and its application in real world. The suggested ontology for network-based businesses is composed of individuals` characteristics and what kind of resources they own. also, their connections and pre-conceptions of connections...... such as shared-mental model and trust. However, it mostly covers previous business model elements. To confirm the applicability of this ontology, it has been implemented in business angel network and showed how it works....

  16. A decision-making model for engineering designers

    DEFF Research Database (Denmark)

    Ahmed, S.; Hansen, Claus Thorp

    2002-01-01

    This paper describes research that combines the generic decision-making model of Hansen, together with design strategies employed by experienced engineering designers. The relationship between the six decision-making sub-activities and the eight design strategies are examined. By combining...

  17. A Review of Research on Universal Design Educational Models

    Science.gov (United States)

    Rao, Kavita; Ok, Min Wook; Bryant, Brian R.

    2014-01-01

    Universal design for learning (UDL) has gained considerable attention in the field of special education, acclaimed for its promise to promote inclusion by supporting access to the general curriculum. In addition to UDL, there are two other universal design (UD) educational models referenced in the literature, universal design of instruction (UDI)…

  18. A Review of Research on Universal Design Educational Models

    Science.gov (United States)

    Rao, Kavita; Ok, Min Wook; Bryant, Brian R.

    2014-01-01

    Universal design for learning (UDL) has gained considerable attention in the field of special education, acclaimed for its promise to promote inclusion by supporting access to the general curriculum. In addition to UDL, there are two other universal design (UD) educational models referenced in the literature, universal design of instruction (UDI)…

  19. Implications of Building Information Modeling on Interior Design Education: The Impact on Teaching Design Processes

    Directory of Open Access Journals (Sweden)

    Amy Roehl, MFA

    2013-06-01

    Full Text Available Currently, major shifts occur in design processes effecting business practices for industries involved with designing and delivering the built environment. These changing conditions are a direct result of industry adoption of relatively new technologies called BIM or Building Information Modeling. This review of literature examines implications of these changing processes on interior design education.

  20. Implications of Building Information Modeling on Interior Design Education: The Impact on Teaching Design Processes

    Directory of Open Access Journals (Sweden)

    Amy Roehl, MFA

    2013-06-01

    Full Text Available Currently, major shifts occur in design processes effecting business practices for industries involved with designing and delivering the built environment. These changing conditions are a direct result of industry adoption of relatively new technologies called BIM or Building Information Modeling. This review of literature examines implications of these changing processes on interior design education.

  1. Service Design, insights from nine case studies

    NARCIS (Netherlands)

    Enninga, Tanja; Manschot, M.M.; Gessel, C. van; Gijbels, J.; Lugt, Remko van der; Sleeswijk Visser, Sjoukje; Verhoeven, Fenne; Godfroij, Berit

    2013-01-01

    Service design is literally the design of services. Service designers improve existing services or design completely new ones. Nothing new so far. Services have been around for centuries, and every service was conceived and designed by someone. However, service design takes a different angle; a diff

  2. A product-model supporting coupling's management during microproduct design

    DEFF Research Database (Denmark)

    Museau, Matthieu; De Grave, Arnaud; Masclet, Cedric

    2009-01-01

    Microproducts show specificities compared to macroproducts and their design processes differ. Nowadays, existing design tools manage microproduct specificities too late during the design process, only after the first product representation is available. This article presents a product-model able...... to represent microproducts during the design flow, taking into account their specificities and exceeding the limits of product representation in actual design tools. The genericity of this model is demonstrated by the instantiation of a micro electro mechanical system (MEMS) radio frequency (RF) switch....

  3. FEL Design Studies at LBNL: Activities and Plans

    Energy Technology Data Exchange (ETDEWEB)

    Corlett, John N.; Fawley, W.; Lidia, S.; Padmore, H.; Penn, G.; Pogorelov, I.; Qiang, J.; Sannibale, F.; Staples, J.; Steier, C.; Venturini, M.; Wan, W.; Wilcox, R.; Zholents, A.

    2007-03-01

    LBNL staff are currently pursuing R&D for future x-ray FELs, and participate in two FEL construction projects. Our strategy is to address the most fundamental challenges, which are the cost-drivers and performance limitations of FEL facilities. An internally funded R&D program is aimed at investigating accelerator physics and technologies in three key areas: (1) Theoretical study, modeling, and experimental development of low emittance, high quantum efficiency cathodes; (2) Design studies of electron beam delivery systems, including emittance manipulations, high-resolution modeling of 6-D phase space, and low-emittance beam transport; and (3) Design studies of optical manipulations of electron beams for seeded and SASE FELs, providing short x-ray pulses of variable duration, synchronous with the seed and pump laser sources, and also long transform-limited pulses with a narrow bandwidth. Design studies of means for production of attosecond x-ray pulses at various wavelengths. We are collaborators in the FERMI{at}Elettra seeded FEL facility under construction at Sincrotrone Trieste, Italy, participating in accelerator design and FEL physics studies, and mechanical and electrical engineering. We are participating in the LCLS project at SLAC, implementing our design of stabilized timing and synchronization systems. Here we outline our long-term objectives, and current activities.

  4. Design Transformations for Rule-based Procedural Modeling

    KAUST Repository

    Lienhard, Stefan

    2017-05-24

    We introduce design transformations for rule-based procedural models, e.g., for buildings and plants. Given two or more procedural designs, each specified by a grammar, a design transformation combines elements of the existing designs to generate new designs. We introduce two technical components to enable design transformations. First, we extend the concept of discrete rule switching to rule merging, leading to a very large shape space for combining procedural models. Second, we propose an algorithm to jointly derive two or more grammars, called grammar co-derivation. We demonstrate two applications of our work: we show that our framework leads to a larger variety of models than previous work, and we show fine-grained transformation sequences between two procedural models.

  5. On infrastructure network design with agent-based modelling

    NARCIS (Netherlands)

    Chappin, E.J.L.; Heijnen, P.W.

    2014-01-01

    We have developed an agent-based model to optimize green-field network design in an industrial area. We aim to capture some of the deep uncertainties surrounding infrastructure design by modelling it developing specific ant colony optimizations. Hence, we propose a variety of extensions to our

  6. Surrogate Modeling for Geometry Optimization in Material Design

    DEFF Research Database (Denmark)

    Rojas Larrazabal, Marielba de la Caridad; Abraham, Yonas B.; Holzwarth, Natalie A.W.;

    2007-01-01

    We propose a new approach based on surrogate modeling for geometry optimization in material design. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)......We propose a new approach based on surrogate modeling for geometry optimization in material design. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)...

  7. A stage-based model of design teaching

    DEFF Research Database (Denmark)

    Beier, Sofie

    2014-01-01

    With a focus on the teaching of design students in higher education, the article will present a teaching approach model that follows the stages of the design process. The model suggests that at the Definition stage, the supervisor can focus on leading the student into a more thorough elaboration...

  8. Estimated Frequency Domain Model Uncertainties used in Robust Controller Design

    DEFF Research Database (Denmark)

    Tøffner-Clausen, S.; Andersen, Palle; Stoustrup, Jakob;

    1994-01-01

    This paper deals with the combination of system identification and robust controller design. Recent results on estimation of frequency domain model uncertainty are......This paper deals with the combination of system identification and robust controller design. Recent results on estimation of frequency domain model uncertainty are...

  9. On infrastructure network design with agent-based modelling

    NARCIS (Netherlands)

    Chappin, E.J.L.; Heijnen, P.W.

    2014-01-01

    We have developed an agent-based model to optimize green-field network design in an industrial area. We aim to capture some of the deep uncertainties surrounding infrastructure design by modelling it developing specific ant colony optimizations. Hence, we propose a variety of extensions to our exist

  10. Conceptual Model of Artifacts for Design Science Research

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    2015-01-01

    We present a conceptual model of design science research artifacts. The model views an artifact at three levels. At the artifact level a selected artifact is viewed as a combination of material and immaterial aspects and a set of representations hereof. At the design level the selected artifact...

  11. Irradiation Design for an Experimental Murine Model

    Science.gov (United States)

    Ballesteros-Zebadúa, P.; Lárraga-Gutierrez, J. M.; García-Garduño, O. A.; Rubio-Osornio, M. C.; Custodio-Ramírez, V.; Moreno-Jimenez, S.; Suarez-Campos, J. E.; Paz, C.; Celis, M. A.

    2010-12-01

    In radiotherapy and stereotactic radiosurgery, small animal experimental models are frequently used, since there are still a lot of unsolved questions about the biological and biochemical effects of ionizing radiation. This work presents a method for small-animal brain radiotherapy compatible with a dedicated 6MV Linac. This rodent model is focused on the research of the inflammatory effects produced by ionizing radiation in the brain. In this work comparisons between Pencil Beam and Monte Carlo techniques, were used in order to evaluate accuracy of the calculated dose using a commercial planning system. Challenges in this murine model are discussed.

  12. Modelling the role of the design context in the design process: a domain-independent approach

    NARCIS (Netherlands)

    Reymen, Isabelle; Kroes, P.; Basten, T; Durling, D.; Shackleton, J.

    2002-01-01

    Domain-independent models of the design process are an important means for facilitating interdisciplinary communication and for supporting multidisciplinary design. Many so-called domain-independent models are, however, not really domain independent. We state that, to be domain independent, the

  13. A domain-independent descriptive design model and its application to structured reflection on design processes

    NARCIS (Netherlands)

    Reymen, Isabelle; Hammer, D.K.; Kroes, P.A.; van Aken, Joan Ernst; van Aken, J.E.; Dorst, C.H.; Bax, M.F.T.; Basten, T

    2006-01-01

    Domain-independent models of the design process are an important means for facilitating interdisciplinary communication and for supporting multidisciplinary design. Many so-called domain-independent models are, however, not really domain independent. We state that to be domain independent, the

  14. The 3 "C" Design Model for Networked Collaborative E-Learning: A Tool for Novice Designers

    Science.gov (United States)

    Bird, Len

    2007-01-01

    This paper outlines a model for online course design aimed at the mainstream majority of university academics rather than at the early adopters of technology. It has been developed from work at Coventry Business School where tutors have been called upon to design online modules for the first time. Like many good tools, the model's key strength is…

  15. Optimizing Intermodal Train Schedules with a Design Balanced Network Design Model

    DEFF Research Database (Denmark)

    Pedersen, Michael Berliner; Crainic, Teodor Gabriel

    We present a modeling approach for optimizing intermodal trains schedules based on an infrastructure divided into time-dependent train paths. The formulation can be generalized to a capacitated multi commodity network design model with additional design balance constraints. We present a Tabu Search...

  16. Design, modeling and control of nanopositioning systems

    CERN Document Server

    Fleming, Andrew J

    2014-01-01

    Covering the complete design cycle of nanopositioning systems, this is the first comprehensive text on the topic. The book first introduces concepts associated with nanopositioning stages and outlines their application in such tasks as scanning probe microscopy, nanofabrication, data storage, cell surgery and precision optics. Piezoelectric transducers, employed ubiquitously in nanopositioning applications are then discussed in detail including practical considerations and constraints on transducer response. The reader is then given an overview of the types of nanopositioner before the text turns to the in-depth coverage of mechanical design including flexures, materials, manufacturing techniques, and electronics. This process is illustrated by the example of a high-speed serial-kinematic nanopositioner. Position sensors are then catalogued and described and the text then focuses on control. Several forms of control are treated: shunt control, feedback control, force feedback control and feedforward control (...

  17. Analyzing, Modelling, and Designing Software Ecosystems

    DEFF Research Database (Denmark)

    Manikas, Konstantinos

    of software ecosystems. We use these contributions to design a software ecosystem in the telemedicine services of Denmark with (i) a common platform that supports and promotes development from different actors, (ii) high software interaction, (iii) strong social network of actors, (iv) robust business...... as the software development and distribution by a set of actors dependent on each other and the ecosystem. We commence on the hypothesis that the establishment of a software ecosystem on the telemedicine services of Denmark would address these issues and investigate how a software ecosystem can foster...... the development, implementation, and use of telemedicine services. We initially expand the theory of software ecosystems by contributing to the definition and understanding of software ecosystems, providing means of analyzing existing and designing new ecosystems, and defining and measuring the qualities...

  18. Interim report on the tandem mirror hybrid design study

    Energy Technology Data Exchange (ETDEWEB)

    Moir, R.W. (ed.)

    1979-08-01

    The initial phase of a 2-year design study of a tandem mirror fusion reactor is presented. The following chapters are included: (1) mechanical design of the plant; (2) plasma physics; (3) blanket design; (4) magnet design; (5) injector design; (6) direct convertor design; (7) balance of plant design; (8) fission burner reactor; (9) environment and safety; and (10) economic analysis. (MOW)

  19. Designing organizational excellence model for cellulose industry of Iran

    Directory of Open Access Journals (Sweden)

    Seyed Abbas Kazemi

    2012-01-01

    Full Text Available Nowadays organizational excellence is regarded as the world’s most effective and progressive issue and many countries and organizations are attempting in the way of applying excellence. In this way, they attempt to improve such models and according to culture and sociopolitical conditions of each country, they attempt to design several models. The present research has been conducted with principal goal of designing organizational excellence model at cellulose industry of Iran. The study determines its components and aspects, priorities the aspects and components and analyzes relationship among different aspects of organizational excellence model at cellulose industry of Iran. The present research is an applied research with respect to goal and it is a descriptive-analytical method in terms of method. Statistical population of the present research covers all experts in the field of cellulose industry of Iran in which on this basis, the number of statistical sample was 207 people from managers to specialists. Results of research indicate that organizational excellence pattern of cellulose industry is a mixture of different aspects of technical, economic, inner environment, outer environment, motivation and behavioral processes.

  20. Design Integration - a theroretical and empirical study of design integration in small and medium sized Danish companies

    DEFF Research Database (Denmark)

    Erichsen, Pia Geisby

    dynamiske modeller i ældre dele af design management litteraturen (som ikke blev identificeret i første litteratur studie a design management). Her blev Dumas & Mintzbergs (1989) forskning identificeret som en relevant model for at få en bedre forståelse af designintegration. Inddragelsen af disse...... fokus i organisationen, manglende nuancer i forståelsen af designs mulige retninger, design blev forbundet med risiko, mangel på tid, og design kunne ikke differentieres fra andre teoretiske discipliner så som marketing. I case studiet indikeres imidlertid også at en drivkraft for at overkomme disse...