WorldWideScience

Sample records for model small library

  1. Best Small Library in American 2008: Chelsea District Library--A Michigan Model

    Science.gov (United States)

    Berry, John N., III

    2008-01-01

    This article features Chelsea District Library (CDL), Michigan, which claims recognition as the 2008 Best Small Library in America, an award sponsored by "Library Journal" and the Bill & Melinda Gates Foundation. The aggressively responsive staff of CDL has created a model for small libraries all over America. There, careful…

  2. Small Public Library Management

    Science.gov (United States)

    Pearlmutter, Jane; Nelson, Paul

    2012-01-01

    Anyone at the helm of a small public library knows that every little detail counts. But juggling the responsibilities that are part and parcel of the job is far from easy. Finally, here's a handbook that includes everything administrators need to keep a handle on library operations, freeing them up to streamline and improve how the organization…

  3. The small library manager's handbook

    CERN Document Server

    Graves, Alice

    2014-01-01

    The Small Library Manager's Handbook is for librarians working in all types of small libraries. It covers the everyday nuts-and-bolts operations that all librarians must perform. This handbook, written by experts who are small librarians themselves, will help all small librarians to do multiple jobs at the same time.

  4. Small libraries a handbook for successful management

    CERN Document Server

    Reed, Sally Gardner

    2002-01-01

    ""A gem""--Booklist; ""outstanding""--Library Journal; ""indispensable, invaluable""--Midwest Book Review; ""one of the best...wonderful""--Wilson Library Bulletin. This fully revised and updated edition provides current information on automation and technology and on advocacy to help small public libraries strive to make available the same basic services as larger libraries. This book is written for the directors of these honest-to-goodness small libraries, providing both a philosophical as well as a common sense basis for decision making.

  5. Integrated Library Systems for Small Libraries: Estimating the Cost.

    Science.gov (United States)

    Havercamp, Dan

    1985-01-01

    The "average" costs of integrated library system components--including hardware, software, and related expenses--are outlined to assist in projecting the costs of a small system. Potential benefits of such systems, i.e., areas in which operational costs can be reduced through their use, are also reviewed. (EJS)

  6. Small Molecule Library Synthesis Using Segmented Flow

    Directory of Open Access Journals (Sweden)

    Christina M. Thompson

    2011-11-01

    Full Text Available Flow chemistry has gained considerable recognition as a simple, efficient, and safe technology for the synthesis of many types of organic and inorganic molecules ranging in scope from large complex natural products to silicon nanoparticles. In this paper we describe a method that adapts flow chemistry to the synthesis of libraries of compounds using a fluorous immiscible solvent as a spacer between reactions. The methodology was validated in the synthesis of two small heterocycle containing libraries. The reactions were performed on a 0.2 mmol scale, enabling tens of milligrams of material to be generated in a single 200 mL reaction plug. The methodology allowed library synthesis in half the time of conventional microwave synthesis while maintaining similar yields. The ability to perform multiple, potentially unrelated reactions in a single run is ideal for making small quantities of many different compounds quickly and efficiently.

  7. Newspaper Indexing Handbook for Small Libraries.

    Science.gov (United States)

    Smith, Donald R.

    This presentation of a simplified procedure for indexing local newspapers at a small library includes a brief discussion of 23 guidelines and rules for subject heading selection and use, indexing, and filing; a group of sample cards in the prescribed filing order; and a bibliography on newspaper indexing. (SW)

  8. A Disaster Preparedness Plan for Small Public Libraries, 2002.

    Science.gov (United States)

    Haines, Jan, Comp.

    The State Library of Ohio designed this disaster preparedness plan to assist small libraries in gathering information that will be invaluable in the event of an emergency. This plan, which focuses on fire and water disaster prevention, is devoted to using simple and inexpensive measures to prevent a disaster or to lessen its effect. The plan…

  9. Small-molecule discovery from DNA-encoded chemical libraries.

    Science.gov (United States)

    Kleiner, Ralph E; Dumelin, Christoph E; Liu, David R

    2011-12-01

    Researchers seeking to improve the efficiency and cost effectiveness of the bioactive small-molecule discovery process have recently embraced selection-based approaches, which in principle offer much higher throughput and simpler infrastructure requirements compared with traditional small-molecule screening methods. Since selection methods benefit greatly from an information-encoding molecule that can be readily amplified and decoded, several academic and industrial groups have turned to DNA as the basis for library encoding and, in some cases, library synthesis. The resulting DNA-encoded synthetic small-molecule libraries, integrated with the high sensitivity of PCR and the recent development of ultra high-throughput DNA sequencing technology, can be evaluated very rapidly for binding or bond formation with a target of interest while consuming minimal quantities of material and requiring only modest investments of time and equipment. In this tutorial review we describe the development of two classes of approaches for encoding chemical structures and reactivity with DNA: DNA-recorded library synthesis, in which encoding and library synthesis take place separately, and DNA-directed library synthesis, in which DNA both encodes and templates library synthesis. We also describe in vitro selection methods used to evaluate DNA-encoded libraries and summarize successful applications of these approaches to the discovery of bioactive small molecules and novel chemical reactivity.

  10. Library 2.0 A New Service Model For Libraries

    Directory of Open Access Journals (Sweden)

    Agnes Erich

    2007-01-01

    Full Text Available The utilization of the new information and communication technologies implies a series of changes concerning the libraries. Currently it is spoken more and more about a new type of service offered by them, Library 2.0, which brings in foreground the user who becomes a modeler of the library services and resources. The information structures customer is not satisfied anymore by the unidirectional access to the resources, he wanted to be involved in the evaluation of them, making comments and sharing his ideas with another user. In this sense the library managers are looking for more efficient means to deliver services so that to obtain a proper feedback which enable them to take the best measures to make profitable them. Library 2.0 can be a solution for all these problems.

  11. Attitudes about OCLC in Small and Medium-Sized Libraries. Illinois Valley Library System OCLC Experimental Project. Report No. 4.

    Science.gov (United States)

    Bills, Linda G.; Wilford, Valerie

    A project was conducted from 1980 to 1982 to determine the costs and benefits of OCLC use in 29 small and medium-sized member libraries of the Illinois Valley Library System (IVLS). Academic, school, public, and special libraries participated in the project. Based on written attitude surveys of and interviews with library directors, staff,…

  12. SOLIB: A Social Science Program Library for Small Computers.

    Science.gov (United States)

    Halley, Fred S.

    A package of social science programs--Sociology Library (SOLIB)--for small computers provides users with a partial solution to the problems stemming from the heterogeneity of social science applications programs. SOLIB offers a uniform approach to data handling and program documentation; all its programs are written in standard FORTRAN for the IBM…

  13. Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening.

    Science.gov (United States)

    Wu, Chun-Yi; Wang, Don-Hong; Wang, Xiaobing; Dixon, Seth M; Meng, Liping; Ahadi, Sara; Enter, Daniel H; Chen, Chao-Yu; Kato, Jason; Leon, Leonardo J; Ramirez, Laura M; Maeda, Yoshiko; Reis, Carolina F; Ribeiro, Brianna; Weems, Brittany; Kung, Hsing-Jien; Lam, Kit S

    2016-06-13

    Identifying "druggable" targets and their corresponding therapeutic agents are two fundamental challenges in drug discovery research. The one-bead-one-compound (OBOC) combinatorial library method has been developed to discover peptides or small molecules that bind to a specific target protein or elicit a specific cellular response. The phage display cDNA expression proteome library method has been employed to identify target proteins that interact with specific compounds. Here, we combined these two high-throughput approaches, efficiently interrogated approximately 10(13) possible molecular interactions, and identified 91 small molecule compound beads that interacted strongly with the phage library. Of 19 compounds resynthesized, 4 were cytotoxic against cancer cells; one of these compounds was found to interact with EIF5B and inhibit protein translation. As more binding pairs are confirmed and evaluated, the "library-against-library" screening approach and the resulting small molecule-protein domain interaction database may serve as a valuable tool for basic research and drug development.

  14. DNA-encoded chemical libraries: advancing beyond conventional small-molecule libraries.

    Science.gov (United States)

    Franzini, Raphael M; Neri, Dario; Scheuermann, Jörg

    2014-04-15

    DNA-encoded chemical libraries (DECLs) represent a promising tool in drug discovery. DECL technology allows the synthesis and screening of chemical libraries of unprecedented size at moderate costs. In analogy to phage-display technology, where large antibody libraries are displayed on the surface of filamentous phage and are genetically encoded in the phage genome, DECLs feature the display of individual small organic chemical moieties on DNA fragments serving as amplifiable identification barcodes. The DNA-tag facilitates the synthesis and allows the simultaneous screening of very large sets of compounds (up to billions of molecules), because the hit compounds can easily be identified and quantified by PCR-amplification of the DNA-barcode followed by high-throughput DNA sequencing. Several approaches have been used to generate DECLs, differing both in the methods used for library encoding and for the combinatorial assembly of chemical moieties. For example, DECLs can be used for fragment-based drug discovery, displaying a single molecule on DNA or two chemical moieties at the extremities of complementary DNA strands. DECLs can vary substantially in the chemical structures and the library size. While ultralarge libraries containing billions of compounds have been reported containing four or more sets of building blocks, also smaller libraries have been shown to be efficient for ligand discovery. In general, it has been found that the overall library size is a poor predictor for library performance and that the number and diversity of the building blocks are rather important indicators. Smaller libraries consisting of two to three sets of building blocks better fulfill the criteria of drug-likeness and often have higher quality. In this Account, we present advances in the DECL field from proof-of-principle studies to practical applications for drug discovery, both in industry and in academia. DECL technology can yield specific binders to a variety of target

  15. Mixture-based combinatorial libraries from small individual peptide libraries: a case study on α1-antitrypsin deficiency.

    Science.gov (United States)

    Chang, Yi-Pin; Chu, Yen-Ho

    2014-05-16

    The design, synthesis and screening of diversity-oriented peptide libraries using a "libraries from libraries" strategy for the development of inhibitors of α1-antitrypsin deficiency are described. The major buttress of the biochemical approach presented here is the use of well-established solid-phase split-and-mix method for the generation of mixture-based libraries. The combinatorial technique iterative deconvolution was employed for library screening. While molecular diversity is the general consideration of combinatorial libraries, exquisite design through systematic screening of small individual libraries is a prerequisite for effective library screening and can avoid potential problems in some cases. This review will also illustrate how large peptide libraries were designed, as well as how a conformation-sensitive assay was developed based on the mechanism of the conformational disease. Finally, the combinatorially selected peptide inhibitor capable of blocking abnormal protein aggregation will be characterized by biophysical, cellular and computational methods.

  16. Small targeted cytotoxics from DNA-encoded chemical libraries.

    Science.gov (United States)

    Samain, Florent; Casi, Giulio

    2015-06-01

    Conventional chemotherapeutic drugs do not selectively localize to tumors, causing undesired toxicities to healthy organs, and precluding the escalation to therapeutically active regimens. The selective delivery at sites of disease of potent effector molecules represents a promising strategy for the treatment of cancer and other diseases. High affinity antibodies towards disease-associated antigens are currently the vehicles of choice for the targeted delivery of payloads. Low molecular weight ligands have the potential to overcome some of the intrinsic limitations associated with antibodies, and have recently been proposed for the development of a novel class of targeted therapeutics. However, the identification of binding molecules, which display high affinity properties and exquisite specificity against protein of therapeutic interest, remains a great challenge. DNA-encoded chemical library technology relies on small molecule libraries of unprecedented size to identify high affinity ligands towards specific target proteins, and could help in the development of next generation targeted cytotoxics.

  17. Mixture-Based Combinatorial Libraries from Small Individual Peptide Libraries: A Case Study on α1-Antitrypsin Deficiency

    Directory of Open Access Journals (Sweden)

    Yi-Pin Chang

    2014-05-01

    Full Text Available The design, synthesis and screening of diversity-oriented peptide libraries using a “libraries from libraries” strategy for the development of inhibitors of α1-antitrypsin deficiency are described. The major buttress of the biochemical approach presented here is the use of well-established solid-phase split-and-mix method for the generation of mixture-based libraries. The combinatorial technique iterative deconvolution was employed for library screening. While molecular diversity is the general consideration of combinatorial libraries, exquisite design through systematic screening of small individual libraries is a prerequisite for effective library screening and can avoid potential problems in some cases. This review will also illustrate how large peptide libraries were designed, as well as how a conformation-sensitive assay was developed based on the mechanism of the conformational disease. Finally, the combinatorially selected peptide inhibitor capable of blocking abnormal protein aggregation will be characterized by biophysical, cellular and computational methods.

  18. SMALL SCALE MORPHODYNAMICAL MODELLING

    Institute of Scientific and Technical Information of China (English)

    D. Ditschke; O. Gothel; H. Weilbeer

    2001-01-01

    Long term morphological simulations using complete coupled models lead to very time consuming computations. Latteux (1995) presented modelling techniques developed for tidal current situations in order to reduce the computational effort. In this paper the applicability of such methods to small scale problems is investigated. It is pointed out that these methods can be transferred to small scale problems using the periodicity of the vortex shedding process.

  19. An updated MILES stellar library and stellar population models (Research Note)

    NARCIS (Netherlands)

    Falcon-Barroso, J.; Sanchez-Blazquez, P.; Vazdekis, A.; Ricciardelli, E.; Cardiel, N.; Cenarro, A. J.; Gorgas, J.; Peletier, R. F.

    Aims: We present a number of improvements to the MILES library and stellar population models. We correct some small errors in the radial velocities of the stars, measure the spectral resolution of the library and models more accurately, and give a better absolute flux calibration of the models.

  20. Arrangement of library materials models in Slovene public libraries

    Directory of Open Access Journals (Sweden)

    Marija Kobal

    2009-01-01

    Full Text Available The classification and the alignment of library material represent an important part of the library science from its early beginnings onwards. The introduction of UDC into Slovene public libraries coincided with the alteration of the open access library collection.In Slovenia the public libraries in average take into account the references and recommendations for the arrangement of the free access library collection, considering the age groups of the users, adults and juniors. The next division is connected with the functional type of the material, which is divided into fiction, and scientific material,and then there is the UDC label for the arrangement of the material on the shelves or word systematic in one of the public libraries. In the junior department there is a need for a further division into four age/reading groups of books instead of three.Within the formed groups there is the further arrangement of books in an alphabetical order by means of author or subject headings. The public library is a unit, which services all the residents in its local area. The different needs and interests of users should take into account in the formation of a library material arrangement.

  1. Amino acid alphabet size in protein evolution experiments: better to search a small library thoroughly or a large library sparsely?

    Science.gov (United States)

    Muñoz, Enrique; Deem, Michael W

    2008-05-01

    We compare the results obtained from searching a smaller library thoroughly versus searching a more diverse, larger library sparsely. We study protein evolution with reduced amino acid alphabets, by simulating directed evolution experiments at three different alphabet sizes: 20, 5 and 2. We employ a physical model for evolution, the generalized NK model, that has proved successful in modeling protein evolution, antibody evolution and T-cell selection. We find that antibodies with higher affinity are found by searching a library with a larger alphabet sparsely than by searching a smaller library thoroughly, even with well-designed reduced libraries. We also find ranked amino acid usage frequencies in agreement with observations of the CDR-H3 variable region of human antibodies.

  2. Library faculty role in problem-based learning: facilitating small groups.

    OpenAIRE

    Satterthwaite, R K; Helms, M E; Nouravarsani, R; Van Antwerp, M; Woelfl, N N

    1995-01-01

    Since 1986, the library faculty of the McGoogan Library of Medicine at the University of Nebraska Medical Center (UNMC) has participated in small group activities during the week-long orientation for first-year medical students. This involvement paved the way for library faculty members to act as facilitators for small groups of medical students within the new problem-based learning (PBL) curriculum introduced in 1992 by the College of Medicine. The UNMC curriculum consists of traditional PBL...

  3. Computer and Network Security in Small Libraries: A Guide for Planning.

    Science.gov (United States)

    Williams, Robert L.

    This manual is intended to provide a free resource on essential network security concepts for non-technical managers of small libraries. Managers of other small nonprofit or community organizations will also benefit from it. An introduction defines network security; outlines three goals of network security; discusses why a library should be…

  4. Include Your Patrons in Web Design. Computers in Small Libraries

    Science.gov (United States)

    Roberts, Gary

    2005-01-01

    Successful Web publishing requires not only technical skills but also a refined sense of taste, a good understanding of design, and strong writing abilities. When designing a library Web page, a person must possess all of these talents and be able to market to a broad spectrum of patrons. As a result, library sites vary widely in their style and…

  5. High Speed Development and Synthesis of Novel Small Molecule Libraries

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@ Combinatorial chemistry has produced libraries of millions of compounds in the last decade. Screening of those compounds, unfortunately, has not yet yielded as many new drug candidates as initially expected. Among a number of possible reasons, one is that many libraries combinatorial chemistry produced in the early periods are of the nature of linear, flat, and flexible molecules such as peptides and oligonucleotides, which do not have the desired properties to selectively interact with their targets to yield high quality hits and leads. In order to increase the number of quality hits and leads, rigid, structural featurerich and drug-like compound libraries are highly desirable. Design and development of structural features-rich and natural product-like combinatorial libraries, as well as high speed library production using modern solution and solid phase synthesis techniques such as IRORI's Directed Sorting technology, will be discussed.

  6. High Speed Development and Synthesis of Novel Small Molecule Libraries

    Institute of Scientific and Technical Information of China (English)

    XIAO; Xiao-Yi

    2001-01-01

    Combinatorial chemistry has produced libraries of millions of compounds in the last decade. Screening of those compounds, unfortunately, has not yet yielded as many new drug candidates as initially expected. Among a number of possible reasons, one is that many libraries combinatorial chemistry produced in the early periods are of the nature of linear, flat, and flexible molecules such as peptides and oligonucleotides, which do not have the desired properties to selectively interact with their targets to yield high quality hits and leads. In order to increase the number of quality hits and leads, rigid, structural featurerich and drug-like compound libraries are highly desirable. Design and development of structural features-rich and natural product-like combinatorial libraries, as well as high speed library production using modern solution and solid phase synthesis techniques such as IRORI's Directed Sorting technology, will be discussed.  ……

  7. Indian Consortia Models: FORSA Libraries' Experiences

    Science.gov (United States)

    Patil, Y. M.; Birdie, C.; Bawdekar, N.; Barve, S.; Anilkumar, N.

    2007-10-01

    With increases in prices of journals, shrinking library budgets and cuts in subscriptions to journals over the years, there has been a big challenge facing Indian library professionals to cope with the proliferation of electronic information resources. There have been sporadic efforts by different groups of libraries in forming consortia at different levels. The types of consortia identified are generally based on various models evolved in India in a variety of forms depending upon the participants' affiliations and funding sources. Indian astronomy library professionals have formed a group called Forum for Resource Sharing in Astronomy and Astrophysics (FORSA), which falls under `Open Consortia', wherein participants are affiliated to different government departments. This is a model where professionals willingly come forward and actively support consortia formation; thereby everyone benefits. As such, FORSA has realized four consortia, viz. Nature Online Consortium; Indian Astrophysics Consortium for physics/astronomy journals of Springer/Kluwer; Consortium for Scientific American Online Archive (EBSCO); and Open Consortium for Lecture Notes in Physics (Springer), which are discussed briefly.

  8. Small, Fast S-Expression Library, Version 1.0

    Energy Technology Data Exchange (ETDEWEB)

    2004-12-02

    This software is a library for C and C++ programmers to use for fast and efficient parsing and processing of symbolic expressions, or s-expressions. An s-expression is a text-representation of a tree data structure, and is the basis for the syntax of the LISP and Scheme programming languages. Multiple similar libraries exist, but this one was designed from the ground up for speed, efficiency, and simplicity.

  9. Outline and Preliminary Evaluation of the Classical Digital Library Model.

    Science.gov (United States)

    MacCall, Steven L.; Cleveland, Ana D.; Gibson, Ian E.

    1999-01-01

    Outlines the classical digital library model, which is derived from traditional practices of library and information science professionals, as an alternative to the database retrieval model. Reports preliminary results from an evaluation study of library and information professionals and endusers involved with primary care medicine. (AEF)

  10. The small and rural academic library leveraging resources and overcoming limitations

    CERN Document Server

    Davis Kendrick, Kaetrena

    2016-01-01

    Through the use of case studies, research, and practical interviews, The Small or Rural Academic Library: Leveraging Resources and Overcoming Limitations explores how academic librarians in such environments can keep pace with, create, and improve modern library practices and services, network with colleagues, and access continuing education and professional development opportunities.

  11. Where's the Library in Service Learning?: Models for Engaged Library Instruction.

    Science.gov (United States)

    Riddle, John S.

    2003-01-01

    Discusses service learning and presents models of instruction that academic libraries might offer to service learning pedagogy. Highlights include the role of information literacy; reflection; affective and cognitive learning outcomes of service learning; impact of service learning on libraries; learning process model; course objectives model;…

  12. Linux Adventures on a Laptop. Computers in Small Libraries

    Science.gov (United States)

    Roberts, Gary

    2005-01-01

    This article discusses the pros and cons of open source software, such as Linux. It asserts that despite the technical difficulties of installing and maintaining this type of software, ultimately it is helpful in terms of knowledge acquisition and as a beneficial investment librarians can make in themselves, their libraries, and their patrons.…

  13. Creating a Database for a Small Corporate Library: NOMAD Bookcat.

    Science.gov (United States)

    Bates, Ellen

    1983-01-01

    Description of NOMAD, a database management system with flexibility and "friendly" design in use at the Bank of America library, focuses on costs, objectives, database structure, access, and its use to create an automated book catalog and spending reports. Six references are included. (EJS)

  14. Design, synthesis and selection of DNA-encoded small-molecule libraries.

    Science.gov (United States)

    Clark, Matthew A; Acharya, Raksha A; Arico-Muendel, Christopher C; Belyanskaya, Svetlana L; Benjamin, Dennis R; Carlson, Neil R; Centrella, Paolo A; Chiu, Cynthia H; Creaser, Steffen P; Cuozzo, John W; Davie, Christopher P; Ding, Yun; Franklin, G Joseph; Franzen, Kurt D; Gefter, Malcolm L; Hale, Steven P; Hansen, Nils J V; Israel, David I; Jiang, Jinwei; Kavarana, Malcolm J; Kelley, Michael S; Kollmann, Christopher S; Li, Fan; Lind, Kenneth; Mataruse, Sibongile; Medeiros, Patricia F; Messer, Jeffrey A; Myers, Paul; O'Keefe, Heather; Oliff, Matthew C; Rise, Cecil E; Satz, Alexander L; Skinner, Steven R; Svendsen, Jennifer L; Tang, Lujia; van Vloten, Kurt; Wagner, Richard W; Yao, Gang; Zhao, Baoguang; Morgan, Barry A

    2009-09-01

    Biochemical combinatorial techniques such as phage display, RNA display and oligonucleotide aptamers have proven to be reliable methods for generation of ligands to protein targets. Adapting these techniques to small synthetic molecules has been a long-sought goal. We report the synthesis and interrogation of an 800-million-member DNA-encoded library in which small molecules are covalently attached to an encoding oligonucleotide. The library was assembled by a combination of chemical and enzymatic synthesis, and interrogated by affinity selection. We describe methods for the selection and deconvolution of the chemical display library, and the discovery of inhibitors for two enzymes: Aurora A kinase and p38 MAP kinase.

  15. The JBEI quantitative metabolic modeling library (jQMM): a python library for modeling microbial metabolism

    DEFF Research Database (Denmark)

    Birkel, Garrett W.; Ghosh, Amit; Kumar, Vinay S.

    2017-01-01

    analysis, new methods for the effective use of the ever more readily available and abundant -omics data (i.e. transcriptomics, proteomics and metabolomics) are urgently needed.Results: The jQMM library presented here provides an open-source, Python-based framework for modeling internal metabolic fluxes...

  16. Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library

    Science.gov (United States)

    Ahn, Seungkirl; Kahsai, Alem W.; Pani, Biswaranjan; Wang, Qin-Ting; Zhao, Shuai; Wall, Alissa L.; Strachan, Ryan T.; Staus, Dean P.; Wingler, Laura M.; Sun, Lillian D.; Sinnaeve, Justine; Choi, Minjung; Cho, Ted; Xu, Thomas T.; Hansen, Gwenn M.; Burnett, Michael B.; Lamerdin, Jane E.; Bassoni, Daniel L.; Gavino, Bryant J.; Husemoen, Gitte; Olsen, Eva K.; Franch, Thomas; Costanzi, Stefano; Chen, Xin; Lefkowitz, Robert J.

    2017-01-01

    The β2-adrenergic receptor (β2AR) has been a model system for understanding regulatory mechanisms of G-protein–coupled receptor (GPCR) actions and plays a significant role in cardiovascular and pulmonary diseases. Because all known β-adrenergic receptor drugs target the orthosteric binding site of the receptor, we set out to isolate allosteric ligands for this receptor by panning DNA-encoded small-molecule libraries comprising 190 million distinct compounds against purified human β2AR. Here, we report the discovery of a small-molecule negative allosteric modulator (antagonist), compound 15 [([4-((2S)-3-(((S)-3-(3-bromophenyl)-1-(methylamino)-1-oxopropan-2-yl)amino)-2-(2-cyclohexyl-2-phenylacetamido)-3-oxopropyl)benzamide], exhibiting a unique chemotype and low micromolar affinity for the β2AR. Binding of 15 to the receptor cooperatively enhances orthosteric inverse agonist binding while negatively modulating binding of orthosteric agonists. Studies with a specific antibody that binds to an intracellular region of the β2AR suggest that 15 binds in proximity to the G-protein binding site on the cytosolic surface of the β2AR. In cell-signaling studies, 15 inhibits cAMP production through the β2AR, but not that mediated by other Gs-coupled receptors. Compound 15 also similarly inhibits β-arrestin recruitment to the activated β2AR. This study presents an allosteric small-molecule ligand for the β2AR and introduces a broadly applicable method for screening DNA-encoded small-molecule libraries against purified GPCR targets. Importantly, such an approach could facilitate the discovery of GPCR drugs with tailored allosteric effects. PMID:28130548

  17. Library faculty role in problem-based learning: facilitating small groups.

    Science.gov (United States)

    Satterthwaite, R K; Helms, M E; Nouravarsani, R; Van Antwerp, M; Woelfl, N N

    1995-10-01

    Since 1986, the library faculty of the McGoogan Library of Medicine at the University of Nebraska Medical Center (UNMC) has participated in small group activities during the week-long orientation for first-year medical students. This involvement paved the way for library faculty members to act as facilitators for small groups of medical students within the new problem-based learning (PBL) curriculum introduced in 1992 by the College of Medicine. The UNMC curriculum consists of traditional PBL groups as well as Integrated Clinical Experience (ICE) small groups. The ICE groups provide opportunities for discussion of the social and behavioral issues that arise in medicine, with the majority of the sessions designed to give students interviewing practice with simulated patients. The ICE small groups meet once a week with either one or two facilitators. Several library faculty members act as facilitators for ICE groups. As a result of this involvement, librarian contacts with College of Medicine faculty have grown in number and depth, there has been a corresponding increase in related activities with the first- and second-year medical students. Participation in ICE groups has caused some difficulties with respect to library work schedules, but it has been immensely rewarding and enriching in terms of professional growth. This paper describes the UNMC curriculum, the evolution and extent of the librarians' involvement, and the future involvement, ramifications, and challenges envisioned for McGoogan faculty and their medical library colleagues.

  18. Automated screening for small organic ligands using DNA-encoded chemical libraries.

    Science.gov (United States)

    Decurtins, Willy; Wichert, Moreno; Franzini, Raphael M; Buller, Fabian; Stravs, Michael A; Zhang, Yixin; Neri, Dario; Scheuermann, Jörg

    2016-04-01

    DNA-encoded chemical libraries (DECLs) are collections of organic compounds that are individually linked to different oligonucleotides, serving as amplifiable identification barcodes. As all compounds in the library can be identified by their DNA tags, they can be mixed and used in affinity-capture experiments on target proteins of interest. In this protocol, we describe the screening process that allows the identification of the few binding molecules within the multiplicity of library members. First, the automated affinity selection process physically isolates binding library members. Second, the DNA codes of the isolated binders are PCR-amplified and subjected to high-throughput DNA sequencing. Third, the obtained sequencing data are evaluated using a C++ program and the results are displayed using MATLAB software. The resulting selection fingerprints facilitate the discrimination of binding from nonbinding library members. The described procedures allow the identification of small organic ligands to biological targets from a DECL within 10 d.

  19. Orthogonality of SFC versus HPLC for small molecule library separation.

    Science.gov (United States)

    Weller, Harold N; Ebinger, Katalin; Bullock, William; Edinger, Kurt J; Hermsmeier, Mark A; Hoffman, Steven L; Nirschl, David S; Swann, Thomas; Zhao, Jiang; Kiplinger, Jeffrey; Lefebvre, Paul

    2010-11-08

    Preparative HPLC and HPLC-MS are well established as the methods of choice for purification of pharmaceutical library compounds. Recent advances in supercritical fluid chromatography (SFC) have now made SFC a viable alternative to HPLC for this application. One of the potential arguments for using SFC in place of, or in addition to, HPLC is that it may offer different selectivity and thus has the potential for improved separation success rates. In this paper, we examine relative success rates for SFC and HPLC in obtaining adequate selectivity for successful separation. Our results suggest that use of SFC in addition to HPLC may result in a slight (1-2%) improvement in success rate compared to use of HPLC alone.

  20. A Remarkable Collection of Rare Scriptures in a Small University Library Setting

    Directory of Open Access Journals (Sweden)

    Teresa Cardin Ellis

    2013-04-01

    Full Text Available Hardin-Simmons University was given two remarkable collections of rare Bibles and a Sefer Torah with the expressed desire of the donors for the collections to be shared with students, faculty and other constituencies of the university's Richardson Library. The library has tried to fulfill this request while attempting to preserve these treasures for future generations. As small university, without a trained archivist or preservationist, we have utilized resources outside our library and contiue to pursue sources to assist us in the maintenance of these special collections while still engaging them in the educational process.

  1. Identification of small molecule aggregators from large compound libraries by support vector machines.

    Science.gov (United States)

    Rao, Hanbing; Li, Zerong; Li, Xiangyuan; Ma, Xiaohua; Ung, Choongyong; Li, Hu; Liu, Xianghui; Chen, Yuzong

    2010-03-01

    Small molecule aggregators non-specifically inhibit multiple unrelated proteins, rendering them therapeutically useless. They frequently appear as false hits and thus need to be eliminated in high-throughput screening campaigns. Computational methods have been explored for identifying aggregators, which have not been tested in screening large compound libraries. We used 1319 aggregators and 128,325 non-aggregators to develop a support vector machines (SVM) aggregator identification model, which was tested by four methods. The first is five fold cross-validation, which showed comparable aggregator and significantly improved non-aggregator identification rates against earlier studies. The second is the independent test of 17 aggregators discovered independently from the training aggregators, 71% of which were correctly identified. The third is retrospective screening of 13M PUBCHEM and 168K MDDR compounds, which predicted 97.9% and 98.7% of the PUBCHEM and MDDR compounds as non-aggregators. The fourth is retrospective screening of 5527 MDDR compounds similar to the known aggregators, 1.14% of which were predicted as aggregators. SVM showed slightly better overall performance against two other machine learning methods based on five fold cross-validation studies of the same settings. Molecular features of aggregation, extracted by a feature selection method, are consistent with published profiles. SVM showed substantial capability in identifying aggregators from large libraries at low false-hit rates. (c) 2009 Wiley Periodicals, Inc.

  2. Selecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening.

    Science.gov (United States)

    Dandapani, Sivaraman; Rosse, Gerard; Southall, Noel; Salvino, Joseph M; Thomas, Craig J

    The selection, acquisition and use of high quality small molecule libraries for screening is an essential aspect of drug discovery and chemical biology programs. Screening libraries continue to evolve as researchers gain a greater appreciation of the suitability of small molecules for specific biological targets, processes and environments. The decisions surrounding the make-up of any given small molecule library is informed by a multitude of variables and opinions vary on best-practices. The fitness of any collection relies upon upfront filtering to avoiding problematic compounds, assess appropriate physicochemical properties, install the ideal level of structural uniqueness and determine the desired extent of molecular complexity. These criteria are under constant evaluation and revision as academic and industrial organizations seek out collections that yield ever improving results from their screening portfolios. Practical questions including cost, compound management, screening sophistication and assay objective also play a significant role in the choice of library composition. This overview attempts to offer advice to all organizations engaged in small molecule screening based upon current best practices and theoretical considerations in library selection and acquisition.

  3. Construction of the BAC Library of Small Abalone (Haliotis diversicolor) for Gene Screening and Genome Characterization.

    Science.gov (United States)

    Jiang, Likun; You, Weiwei; Zhang, Xiaojun; Xu, Jian; Jiang, Yanliang; Wang, Kai; Zhao, Zixia; Chen, Baohua; Zhao, Yunfeng; Mahboob, Shahid; Al-Ghanim, Khalid A; Ke, Caihuan; Xu, Peng

    2016-02-01

    The small abalone (Haliotis diversicolor) is one of the most important aquaculture species in East Asia. To facilitate gene cloning and characterization, genome analysis, and genetic breeding of it, we constructed a large-insert bacterial artificial chromosome (BAC) library, which is an important genetic tool for advanced genetics and genomics research. The small abalone BAC library includes 92,610 clones with an average insert size of 120 Kb, equivalent to approximately 7.6× of the small abalone genome. We set up three-dimensional pools and super pools of 18,432 BAC clones for target gene screening using PCR method. To assess the approach, we screened 12 target genes in these 18,432 BAC clones and identified 16 positive BAC clones. Eight positive BAC clones were then sequenced and assembled with the next generation sequencing platform. The assembled contigs representing these 8 BAC clones spanned 928 Kb of the small abalone genome, providing the first batch of genome sequences for genome evaluation and characterization. The average GC content of small abalone genome was estimated as 40.33%. A total of 21 protein-coding genes, including 7 target genes, were annotated into the 8 BACs, which proved the feasibility of PCR screening approach with three-dimensional pools in small abalone BAC library. One hundred fifty microsatellite loci were also identified from the sequences for marker development in the future. The BAC library and clone pools provided valuable resources and tools for genetic breeding and conservation of H. diversicolor.

  4. A new adaptive data transfer library for model coupling

    Science.gov (United States)

    Zhang, Cheng; Liu, Li; Yang, Guangwen; Li, Ruizhe; Wang, Bin

    2016-06-01

    Data transfer means transferring data fields from a sender to a receiver. It is a fundamental and frequently used operation of a coupler. Most versions of state-of-the-art couplers currently use an implementation based on the point-to-point (P2P) communication of the message passing interface (MPI) (referred to as "P2P implementation" hereafter). In this paper, we reveal the drawbacks of the P2P implementation when the parallel decompositions of the sender and the receiver are different, including low communication bandwidth due to small message size, variable and high number of MPI messages, as well as network contention. To overcome these drawbacks, we propose a butterfly implementation for data transfer. Although the butterfly implementation outperforms the P2P implementation in many cases, it degrades the performance when the sender and the receiver have similar parallel decompositions or when the number of processes used for running models is small. To ensure data transfer with optimal performance, we design and implement an adaptive data transfer library that combines the advantages of both butterfly implementation and P2P implementation. As the adaptive data transfer library automatically uses the best implementation for data transfer, it outperforms the P2P implementation in many cases while it does not decrease the performance in any cases. Now, the adaptive data transfer library is open to the public and has been imported into the C-Coupler1 coupler for performance improvement of data transfer. We believe that other couplers can also benefit from this.

  5. Integrated Platform for Expedited Synthesis-Purification-Testing of Small Molecule Libraries.

    Science.gov (United States)

    Baranczak, Aleksandra; Tu, Noah P; Marjanovic, Jasmina; Searle, Philip A; Vasudevan, Anil; Djuric, Stevan W

    2017-04-13

    The productivity of medicinal chemistry programs can be significantly increased through the introduction of automation, leading to shortened discovery cycle times. Herein, we describe a platform that consolidates synthesis, purification, quantitation, dissolution, and testing of small molecule libraries. The system was validated through the synthesis and testing of two libraries of binders of polycomb protein EED, and excellent correlation of obtained data with results generated through conventional approaches was observed. The fully automated and integrated platform enables batch-supported compound synthesis based on a broad array of chemical transformations with testing in a variety of biochemical assay formats. A library turnaround time of between 24 and 36 h was achieved, and notably, each library synthesis produces sufficient amounts of compounds for further evaluation in secondary assays thereby contributing significantly to the shortening of medicinal chemistry discovery cycles.

  6. A Components Library System Model and the Support Tool

    Institute of Scientific and Technical Information of China (English)

    MIAO Huai-kou; LIU Hui; LIU Jing; LI Xiao-bo

    2004-01-01

    Component-based development needs a well-designed components library and a set of support tools.This paper presents the design and implementation of a components library system model and its support tool UMLCASE.A set of practical CASE tools is constructed.UMLCASE can use UML to design Use Case Diagram, Class Diagram etc.And it integrates with components library system.

  7. The JBEI quantitative metabolic modeling library (jQMM): a python library for modeling microbial metabolism.

    Science.gov (United States)

    Birkel, Garrett W; Ghosh, Amit; Kumar, Vinay S; Weaver, Daniel; Ando, David; Backman, Tyler W H; Arkin, Adam P; Keasling, Jay D; Martín, Héctor García

    2017-04-05

    Modeling of microbial metabolism is a topic of growing importance in biotechnology. Mathematical modeling helps provide a mechanistic understanding for the studied process, separating the main drivers from the circumstantial ones, bounding the outcomes of experiments and guiding engineering approaches. Among different modeling schemes, the quantification of intracellular metabolic fluxes (i.e. the rate of each reaction in cellular metabolism) is of particular interest for metabolic engineering because it describes how carbon and energy flow throughout the cell. In addition to flux analysis, new methods for the effective use of the ever more readily available and abundant -omics data (i.e. transcriptomics, proteomics and metabolomics) are urgently needed. The jQMM library presented here provides an open-source, Python-based framework for modeling internal metabolic fluxes and leveraging other -omics data for the scientific study of cellular metabolism and bioengineering purposes. Firstly, it presents a complete toolbox for simultaneously performing two different types of flux analysis that are typically disjoint: Flux Balance Analysis and (13)C Metabolic Flux Analysis. Moreover, it introduces the capability to use (13)C labeling experimental data to constrain comprehensive genome-scale models through a technique called two-scale (13)C Metabolic Flux Analysis (2S-(13)C MFA). In addition, the library includes a demonstration of a method that uses proteomics data to produce actionable insights to increase biofuel production. Finally, the use of the jQMM library is illustrated through the addition of several Jupyter notebook demonstration files that enhance reproducibility and provide the capability to be adapted to the user's specific needs. jQMM will facilitate the design and metabolic engineering of organisms for biofuels and other chemicals, as well as investigations of cellular metabolism and leveraging -omics data. As an open source software project, we hope it

  8. Modeling and Implementing ISO 13584-based Part Library

    Institute of Scientific and Technical Information of China (English)

    杨东; 肖丽雯; 何援军; 张申生

    2004-01-01

    ISO 13584 (I.e. PLIB) is an international standard for the representation and exchange of CAD part libraries. It aims to provide an application-independent mechanism to enable the share of part library information between applications. In this paper, the approach of modeling part library conforming to ISO 13584 is presented. Also, a prototype of part library management system, I.e. BYL-PLIB, whose implementation is in agreement with ISO 13854 is developed to demonstrate the usefulness of proposed approach.

  9. Solid-Phase Synthesis of Small Molecule Libraries using Double Combinatorial Chemistry

    DEFF Research Database (Denmark)

    Nielsen, John; Jensen, Flemming R.

    1997-01-01

    The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can be demons......The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can...... be demonstrated. The resulting library of model compounds was verified by LC-MS analysis. (C) 1997 Elsevier Science Ltd....

  10. Designing Public Library Websites for Teens: A Conceptual Model

    Science.gov (United States)

    Naughton, Robin Amanda

    2012-01-01

    The main goal of this research study was to develop a conceptual model for the design of public library websites for teens (TLWs) that would enable designers and librarians to create library websites that better suit teens' information needs and practices. It bridges a gap in the research literature between user interface design in human-computer…

  11. Using the Gamma-Poisson Model to Predict Library Circulations.

    Science.gov (United States)

    Burrell, Quentin L.

    1990-01-01

    Argues that the gamma mixture of Poisson processes, for all its perceived defects, can be used to make predictions regarding future library book circulations of a quality adequate for general management requirements. The use of the model is extensively illustrated with data from two academic libraries. (Nine references) (CLB)

  12. Designing Public Library Websites for Teens: A Conceptual Model

    Science.gov (United States)

    Naughton, Robin Amanda

    2012-01-01

    The main goal of this research study was to develop a conceptual model for the design of public library websites for teens (TLWs) that would enable designers and librarians to create library websites that better suit teens' information needs and practices. It bridges a gap in the research literature between user interface design in…

  13. LC-MSMS identification of small molecules; X-Rank, a robust library search algorithm

    OpenAIRE

    Mylonas, Roman

    2010-01-01

    Identification of small molecules is of major importance for many applications. Liquid Chromatography Tandem Mass spectrometry (LC- MSMS) is gaining increasing interest in the field of small molecule identification. LC-MSMS has a broad range of detection, is sensitive and does not need special sample pre-processing. As a major chal- lenge, spectra of the same compound can show great variability across acquisitions. High spectra variability limits the use of LC-MSMS for library search identifi...

  14. Immunoaffinity Ultrafiltration with Ion Spray HPLC/MS for Screening Small-Molecule Libraries.

    Science.gov (United States)

    Wieboldt, R; Zweigenbaum, J; Henion, J

    1997-05-01

    A solution-phase screening method for libraries of pharmaceutically relevant molecules is presented. The technique is applicable to screening combinatorial libraries of 20-30 closely related molecules. In this report, individual benzodiazepines are selected from a multicomponent library mixture by formation in solution of noncovalent immunoaffinity complexes with antibodies raised to therapeutically proven drugs such as nitrazepam, temazepam, or oxazepam. Captured compounds are separated from nonspecifically bound library components by centrifugal ultrafiltration. The specifically selected molecules retained on the filter are subsequently liberated from the antibodies by acidification and analyzed by HPLC coupled with pneumatically assisted electrospray (ion spray) ionization mass spectrometric detection. Competition by the benzodiazepines for limited antibody binding sites is controlled by varying the stoichiometry of the complexation mixture. This procedure selects library components with the greatest affinity for a particular antibody. Specific capture of benzodiazepines is demonstrated by screening both a pool of structurally similar benzodiazepines and a more complex mixture of benzodiazepines with an additional set of unrelated compounds. Affinity ultrafiltration and electrospray mass spectrometry complement each other to enhance screening and identification of pooled drug candidates and potentially can be extended to other small-molecule combinatorial libraries and macromolecular receptor preparations.

  15. Small-fragment genomic libraries for the display of putative epitopes from clinically significant pathogens.

    Science.gov (United States)

    Henics, T; Winkler, B; Pfeifer, U; Gill, S R; Buschle, M; von Gabain, A; Meinke, A L

    2003-07-01

    Taking advantage of whole genome sequences of bacterial pathogens in many thriving diseases with global impact, we developed a comprehensive screening procedure for the identification of putative vaccine candidate antigens. Importantly, this procedure relies on highly representative small-fragment genomic libraries that are expressed to display frame-selected epitope-size peptides on a bacterial cell surface and to interact directly with carefully selected disease-relevant high-titer sera. Here we describe the generation of small-fragment genomic libraries of Gram-positive and Gram-negative clinically significant pathogens, including Staphylococcus aureus and Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus agalactiae, and Streptococcus pneumoniae, Enterococcus faecalis, Helicobacter pylori, Chlamydia pneumoniae, the enterotoxigenic Escherichia coli, and Campylobacter jejuni. Large-scale sequencing revealed that the libraries, which provide an average of 20-fold coverage, were random and, as demonstrated with two S. aureus libraries, highly representative. Consistent with the comprehensive nature of this approach is the identification of epitopes that reside in both annotated and putatively novel open reading frames. The use of these libraries therefore allows for the rapid and direct identification of immunogenic epitopes with no apparent bias or difficulty that often associate with conventional expression methods.

  16. Cloud Computing Platform for an Online Model Library System

    Directory of Open Access Journals (Sweden)

    Mingang Chen

    2013-01-01

    Full Text Available The rapid developing of digital content industry calls for online model libraries. For the efficiency, user experience, and reliability merits of the model library, this paper designs a Web 3D model library system based on a cloud computing platform. Taking into account complex models, which cause difficulties in real-time 3D interaction, we adopt the model simplification and size adaptive adjustment methods to make the system with more efficient interaction. Meanwhile, a cloud-based architecture is developed to ensure the reliability and scalability of the system. The 3D model library system is intended to be accessible by online users with good interactive experiences. The feasibility of the solution has been tested by experiments.

  17. A modular library of small molecule signals regulates social behaviors in Caenorhabditis elegans.

    Directory of Open Access Journals (Sweden)

    Jagan Srinivasan

    2012-01-01

    Full Text Available The nematode C. elegans is an important model for the study of social behaviors. Recent investigations have shown that a family of small molecule signals, the ascarosides, controls population density sensing and mating behavior. However, despite extensive studies of C. elegans aggregation behaviors, no intraspecific signals promoting attraction or aggregation of wild-type hermaphrodites have been identified. Using comparative metabolomics, we show that the known ascarosides are accompanied by a series of derivatives featuring a tryptophan-derived indole moiety. Behavioral assays demonstrate that these indole ascarosides serve as potent intraspecific attraction and aggregation signals for hermaphrodites, in contrast to ascarosides lacking the indole group, which are repulsive. Hermaphrodite attraction to indole ascarosides depends on the ASK amphid sensory neurons. Downstream of the ASK sensory neuron, the interneuron AIA is required for mediating attraction to indole ascarosides instead of the RMG interneurons, which previous studies have shown to integrate attraction and aggregation signals from ASK and other sensory neurons. The role of the RMG interneuron in mediating aggregation and attraction is thought to depend on the neuropeptide Y-like receptor NPR-1, because solitary and social C. elegans strains are distinguished by different npr-1 variants. We show that indole ascarosides promote attraction and aggregation in both solitary and social C. elegans strains. The identification of indole ascarosides as aggregation signals reveals unexpected complexity of social signaling in C. elegans, which appears to be based on a modular library of ascarosides integrating building blocks derived from lipid β-oxidation and amino-acid metabolism. Variation of modules results in strongly altered signaling content, as addition of a tryptophan-derived indole unit to repellent ascarosides produces strongly attractive indole ascarosides. Our findings show

  18. A modular library of small molecule signals regulates social behaviors in Caenorhabditis elegans.

    Science.gov (United States)

    Srinivasan, Jagan; von Reuss, Stephan H; Bose, Neelanjan; Zaslaver, Alon; Mahanti, Parag; Ho, Margaret C; O'Doherty, Oran G; Edison, Arthur S; Sternberg, Paul W; Schroeder, Frank C

    2012-01-01

    The nematode C. elegans is an important model for the study of social behaviors. Recent investigations have shown that a family of small molecule signals, the ascarosides, controls population density sensing and mating behavior. However, despite extensive studies of C. elegans aggregation behaviors, no intraspecific signals promoting attraction or aggregation of wild-type hermaphrodites have been identified. Using comparative metabolomics, we show that the known ascarosides are accompanied by a series of derivatives featuring a tryptophan-derived indole moiety. Behavioral assays demonstrate that these indole ascarosides serve as potent intraspecific attraction and aggregation signals for hermaphrodites, in contrast to ascarosides lacking the indole group, which are repulsive. Hermaphrodite attraction to indole ascarosides depends on the ASK amphid sensory neurons. Downstream of the ASK sensory neuron, the interneuron AIA is required for mediating attraction to indole ascarosides instead of the RMG interneurons, which previous studies have shown to integrate attraction and aggregation signals from ASK and other sensory neurons. The role of the RMG interneuron in mediating aggregation and attraction is thought to depend on the neuropeptide Y-like receptor NPR-1, because solitary and social C. elegans strains are distinguished by different npr-1 variants. We show that indole ascarosides promote attraction and aggregation in both solitary and social C. elegans strains. The identification of indole ascarosides as aggregation signals reveals unexpected complexity of social signaling in C. elegans, which appears to be based on a modular library of ascarosides integrating building blocks derived from lipid β-oxidation and amino-acid metabolism. Variation of modules results in strongly altered signaling content, as addition of a tryptophan-derived indole unit to repellent ascarosides produces strongly attractive indole ascarosides. Our findings show that the library of

  19. Designing Multi-target Compound Libraries with Gaussian Process Models.

    Science.gov (United States)

    Bieler, Michael; Reutlinger, Michael; Rodrigues, Tiago; Schneider, Petra; Kriegl, Jan M; Schneider, Gisbert

    2016-05-01

    We present the application of machine learning models to selecting G protein-coupled receptor (GPCR)-focused compound libraries. The library design process was realized by ant colony optimization. A proprietary Boehringer-Ingelheim reference set consisting of 3519 compounds tested in dose-response assays at 11 GPCR targets served as training data for machine learning and activity prediction. We compared the usability of the proprietary data with a public data set from ChEMBL. Gaussian process models were trained to prioritize compounds from a virtual combinatorial library. We obtained meaningful models for three of the targets (5-HT2c , MCH, A1), which were experimentally confirmed for 12 of 15 selected and synthesized or purchased compounds. Overall, the models trained on the public data predicted the observed assay results more accurately. The results of this study motivate the use of Gaussian process regression on public data for virtual screening and target-focused compound library design.

  20. Identification of Small Molecule Modulators of MicroRNA by Library Screening.

    Science.gov (United States)

    Xiao, Zhangang; Chen, Yangchao

    2017-01-01

    MicroRNAs (miRNAs) function as oncogenes or tumor suppressors and are dysregulated in cancer. miRNAs therefore represent promising therapeutic targets for cancer. Small molecules that could modulate the expression of miRNAs would thus have potential as anticancer agents. Library screening of small molecules targeting miRNAs is a useful technology platform for anticancer drug development. Here, we describe a hepatocellular carcinoma (HCC) cell-based luciferase reporter system which could be used to screen for small molecule modulators of tumor suppressor microRNA-34a.

  1. US Academic Libraries: Today's Learning Commons Model

    Science.gov (United States)

    McMullen, Susan

    2008-01-01

    In 2007, the author examined existing academic libraries in the United States to determine best practices for the design, implementation and service of learning commons facilities. A primary objective of this study was to discover how to create a higher education learning environment that sustains scholarship, encourages collaboration and empowers…

  2. The M4RIE library for dense linear algebra over small fields with even characteristic

    CERN Document Server

    Albrecht, Martin R

    2011-01-01

    In this work, we present the M4RIE library which implements efficient algorithms for linear algebra with dense matrices over GF(2^e) for 2 <= 2 <= 10. As the name of the library indicates, it makes heavy use of the M4RI library both directly (i.e., by calling it) and indirectly (i.e., by using its concepts). We provide an open-source GPLv2+ C library for efficient linear algebra over GF(2^e) for e small. In this library we implemented an idea due to Bradshaw and Boothby which reduces matrix multiplication over GF(p^k) to a series of matrix multiplications over GF(p). Furthermore, we propose a caching technique - Newton-John tables - to avoid finite field multiplications which is inspired by Kronrod's method ("M4RM") for matrix multiplication over GF(2). Using these two techniques we provide asymptotically fast triangular solving with matrices (TRSM) and PLE-based Gaussian elimination. As a result, we are able to significantly improve upon the state of the art in dense linear algebra over GF(2^e) with 2 ...

  3. Modeling Interactions in Small Groups

    Science.gov (United States)

    Heise, David R.

    2013-01-01

    A new theory of interaction within small groups posits that group members initiate actions when tension mounts between the affective meanings of their situational identities and impressions produced by recent events. Actors choose partners and behaviors so as to reduce the tensions. A computer model based on this theory, incorporating reciprocal…

  4. Small-molecule library screening by docking with PyRx.

    Science.gov (United States)

    Dallakyan, Sargis; Olson, Arthur J

    2015-01-01

    Virtual molecular screening is used to dock small-molecule libraries to a macromolecule in order to find lead compounds with desired biological function. This in silico method is well known for its application in computer-aided drug design. This chapter describes how to perform small-molecule virtual screening by docking with PyRx, which is open-source software with an intuitive user interface that runs on all major operating systems (Linux, Windows, and Mac OS). Specific steps for using PyRx, as well as considerations for data preparation, docking, and data analysis, are also described.

  5. Multiscale Computing with the Multiscale Modeling Library and Runtime Environment

    NARCIS (Netherlands)

    Borgdorff, J.; Mamonski, M.; Bosak, B.; Groen, D.; Ben Belgacem, M.; Kurowski, K.; Hoekstra, A.G.

    2013-01-01

    We introduce a software tool to simulate multiscale models: the Multiscale Coupling Library and Environment 2 (MUSCLE 2). MUSCLE 2 is a component-based modeling tool inspired by the multiscale modeling and simulation framework, with an easy-to-use API which supports Java, C++, C, and Fortran. We pre

  6. Distraction and inattention in the driver model library

    NARCIS (Netherlands)

    Hogema, J.H.; Martens, M.H.; Ubink, E.M.

    2011-01-01

    TNO is developing a Driver Model Library (DML) to provide computational models of driver behaviour and decision making for use as a cross-platform plug-in for traffic simulations. The DML is based on a multi-agent cognitive framework which models the individual driving tasks (such as navigation, ove

  7. Modeling a National Collaborative Digital Library for Malaysian Secondary Schools

    Directory of Open Access Journals (Sweden)

    N.N. Edzan

    2004-09-01

    Full Text Available This paper describes the conceptualisation of a model for a collaborative digital library specially tailored for Malaysian secondary schools, which will support classroom teaching and learning. The move towards collaboratively building the contents of a digital library is a fairly recent trend and it simulates an environment where partners are empowered to participate in building and up keeping the knowledge contents of the system. The conceptualisation of a Malaysian digital library is in line with the governments efforts in establishing SMART schools. However, various issues such as identifying local resources, ascertaining the needs of it users, and establishing a framework to meet these needs, must be addressed before the digital library can be fully implemented. It may be approached through the establishment of test beds in a particular learning institution, before nationwide implementation.

  8. Using 4P Marketing Model in Academic Libraries: An Experience

    Directory of Open Access Journals (Sweden)

    Mehdi Alipour Hafezi

    2013-06-01

    Full Text Available The present study mainly aims to demonstrate the weaknesses and strengths of using marketing principles in academic libraries and finally presenting some important suggestions in order to improve their marketing. This study proceeds through expressing the current marketing situation of studied academic libraries from the view point of 4P model. In this regard, the current situation is analyzed using a researcher-made questionnaire, and then the problems and shortcomings are highlighted in the field of marketing in the view point of 4P model which in turn enables us to introduce suggestions to overcome them. This research indicates that marketing principles in the studied libraries are not in a good state. The situation of product dimension is a bit farther up middle state (3.23. Also, the Place dimension with total average of 2.97, Promotion dimension with total average of 2.63 and finally the Price dimension with total average of 1.59 are below the middle state. Therefore, trying to make a good plan in marketing in the four mentioned dimensions is essential for studied academic libraries. Improving academic libraries' statement needs identifying their current situation in the view point of marketing. Consequently, this research studied the current situation of Isfahan governmental academic libraries in order to identify their weaknesses and suggest sufficient suggestions to cover them.

  9. Novel p38α MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library

    DEFF Research Database (Denmark)

    Petersen, L. K.; Blakskjær, P.; Chaikuad, A.

    2016-01-01

    A highly specific and potent (7 nM cellular IC50) inhibitor of p38α kinase was identified directly from a 12.6 million membered DNA-encoded small molecule library. This was achieved using the high fidelity yoctoReactor technology (yR) for preparing the DNA-encoded library, and a homogeneous scree...

  10. Damsel: A Data Model Storage Library for Exascale Science

    Energy Technology Data Exchange (ETDEWEB)

    Koziol, Quincey [The HDF Group

    2014-11-26

    The goal of this project is to enable exascale computational science applications to interact conveniently and efficiently with storage through abstractions that match their data models. We will accomplish this through three major activities: (1) identifying major data model motifs in computational science applications and developing representative benchmarks; (2) developing a data model storage library, called Damsel, that supports these motifs, provides efficient storage data layouts, incorporates optimizations to enable exascale operation, and is tolerant to failures; and (3) productizing Damsel and working with computational scientists to encourage adoption of this library by the scientific community.

  11. Damsel - A Data Model Storage Library for Exascale Science

    Energy Technology Data Exchange (ETDEWEB)

    Samatova, Nagiza F

    2014-07-18

    The goal of this project is to enable exascale computational science applications to interact conveniently and efficiently with storage through abstractions that match their data models. We will accomplish this through three major activities: (1) identifying major data model motifs in computational science applications and developing representative benchmarks; (2) developing a data model storage library, called Damsel, that supports these motifs, provides efficient storage data layouts, incorporates optimizations to enable exascale operation, and is tolerant to failures; and (3) productizing Damsel and working with computational scientists to encourage adoption of this library by the scientific community.

  12. Small targeted cytotoxics: current state and promises from DNA-encoded chemical libraries.

    Science.gov (United States)

    Krall, Nikolaus; Scheuermann, Jörg; Neri, Dario

    2013-01-28

    The targeted delivery of potent cytotoxic agents has emerged as a promising strategy for the treatment of cancer and other serious conditions. Traditionally, antibodies against markers of disease have been used as drug-delivery vehicles. More recently, lower molecular weight ligands have been proposed for the generation of a novel class of targeted cytotoxics with improved properties. Advances in this field crucially rely on efficient methods for the identification and optimization of organic molecules capable of high-affinity binding and selective recognition of target proteins. The advent of DNA-encoded chemical libraries allows the construction and screening of compound collections of unprecedented size. In this Review, we survey developments in the field of small ligand-based targeted cytotoxics and show how innovative library technologies will help develop the drugs of the future.

  13. THE REGRESSION MODEL OF IRAN LIBRARIES ORGANIZATIONAL CLIMATE.

    Science.gov (United States)

    Jahani, Mohammad Ali; Yaminfirooz, Mousa; Siamian, Hasan

    2015-10-01

    The purpose of this study was to drawing a regression model of organizational climate of central libraries of Iran's universities. This study is an applied research. The statistical population of this study consisted of 96 employees of the central libraries of Iran's public universities selected among the 117 universities affiliated to the Ministry of Health by Stratified Sampling method (510 people). Climate Qual localized questionnaire was used as research tools. For predicting the organizational climate pattern of the libraries is used from the multivariate linear regression and track diagram. of the 9 variables affecting organizational climate, 5 variables of innovation, teamwork, customer service, psychological safety and deep diversity play a major role in prediction of the organizational climate of Iran's libraries. The results also indicate that each of these variables with different coefficient have the power to predict organizational climate but the climate score of psychological safety (0.94) plays a very crucial role in predicting the organizational climate. Track diagram showed that five variables of teamwork, customer service, psychological safety, deep diversity and innovation directly effects on the organizational climate variable that contribution of the team work from this influence is more than any other variables. Of the indicator of the organizational climate of climateQual, the contribution of the team work from this influence is more than any other variables that reinforcement of teamwork in academic libraries can be more effective in improving the organizational climate of this type libraries.

  14. THE REGRESSION MODEL OF IRAN LIBRARIES ORGANIZATIONAL CLIMATE

    Science.gov (United States)

    Jahani, Mohammad Ali; Yaminfirooz, Mousa; Siamian, Hasan

    2015-01-01

    Background: The purpose of this study was to drawing a regression model of organizational climate of central libraries of Iran’s universities. Methods: This study is an applied research. The statistical population of this study consisted of 96 employees of the central libraries of Iran’s public universities selected among the 117 universities affiliated to the Ministry of Health by Stratified Sampling method (510 people). Climate Qual localized questionnaire was used as research tools. For predicting the organizational climate pattern of the libraries is used from the multivariate linear regression and track diagram. Results: of the 9 variables affecting organizational climate, 5 variables of innovation, teamwork, customer service, psychological safety and deep diversity play a major role in prediction of the organizational climate of Iran’s libraries. The results also indicate that each of these variables with different coefficient have the power to predict organizational climate but the climate score of psychological safety (0.94) plays a very crucial role in predicting the organizational climate. Track diagram showed that five variables of teamwork, customer service, psychological safety, deep diversity and innovation directly effects on the organizational climate variable that contribution of the team work from this influence is more than any other variables. Conclusions: Of the indicator of the organizational climate of climateQual, the contribution of the team work from this influence is more than any other variables that reinforcement of teamwork in academic libraries can be more effective in improving the organizational climate of this type libraries. PMID:26622203

  15. SearchSmallRNA: a graphical interface tool for the assemblage of viral genomes using small RNA libraries data.

    Science.gov (United States)

    de Andrade, Roberto R S; Vaslin, Maite F S

    2014-03-07

    Next-generation parallel sequencing (NGS) allows the identification of viral pathogens by sequencing the small RNAs of infected hosts. Thus, viral genomes may be assembled from host immune response products without prior virus enrichment, amplification or purification. However, mapping of the vast information obtained presents a bioinformatics challenge. In order to by pass the need of line command and basic bioinformatics knowledge, we develop a mapping software with a graphical interface to the assemblage of viral genomes from small RNA dataset obtained by NGS. SearchSmallRNA was developed in JAVA language version 7 using NetBeans IDE 7.1 software. The program also allows the analysis of the viral small interfering RNAs (vsRNAs) profile; providing an overview of the size distribution and other features of the vsRNAs produced in infected cells. The program performs comparisons between each read sequenced present in a library and a chosen reference genome. Reads showing Hamming distances smaller or equal to an allowed mismatched will be selected as positives and used to the assemblage of a long nucleotide genome sequence. In order to validate the software, distinct analysis using NGS dataset obtained from HIV and two plant viruses were used to reconstruct viral whole genomes. SearchSmallRNA program was able to reconstructed viral genomes using NGS of small RNA dataset with high degree of reliability so it will be a valuable tool for viruses sequencing and discovery. It is accessible and free to all research communities and has the advantage to have an easy-to-use graphical interface. SearchSmallRNA was written in Java and is freely available at http://www.microbiologia.ufrj.br/ssrna/.

  16. Metatranscriptomic analysis of small RNAs present in soybean deep sequencing libraries

    Directory of Open Access Journals (Sweden)

    Lorrayne Gomes Molina

    2012-01-01

    Full Text Available A large number of small RNAs unrelated to the soybean genome were identified after deep sequencing of soybean small RNA libraries. A metatranscriptomic analysis was carried out to identify the origin of these sequences. Comparative analyses of small interference RNAs (siRNAs present in samples collected in open areas corresponding to soybean field plantations and samples from soybean cultivated in greenhouses under a controlled environment were made. Different pathogenic, symbiotic and free-living organisms were identified from samples of both growth systems. They included viruses, bacteria and different groups of fungi. This approach can be useful not only to identify potentially unknown pathogens and pests, but also to understand the relations that soybean plants establish with microorganisms that may affect, directly or indirectly, plant health and crop production.

  17. Large-scale annotation of small-molecule libraries using public databases.

    Science.gov (United States)

    Zhou, Yingyao; Zhou, Bin; Chen, Kaisheng; Yan, S Frank; King, Frederick J; Jiang, Shumei; Winzeler, Elizabeth A

    2007-01-01

    While many large publicly accessible databases provide excellent annotation for biological macromolecules, the same is not true for small chemical compounds. Commercial data sources also fail to encompass an annotation interface for large numbers of compounds and tend to be cost prohibitive to be widely available to biomedical researchers. Therefore, using annotation information for the selection of lead compounds from a modern day high-throughput screening (HTS) campaign presently occurs only under a very limited scale. The recent rapid expansion of the NIH PubChem database provides an opportunity to link existing biological databases with compound catalogs and provides relevant information that potentially could improve the information garnered from large-scale screening efforts. Using the 2.5 million compound collection at the Genomics Institute of the Novartis Research Foundation (GNF) as a model, we determined that approximately 4% of the library contained compounds with potential annotation in such databases as PubChem and the World Drug Index (WDI) as well as related databases such as the Kyoto Encyclopedia of Genes and Genomes (KEGG) and ChemIDplus. Furthermore, the exact structure match analysis showed 32% of GNF compounds can be linked to third party databases via PubChem. We also showed annotations such as MeSH (medical subject headings) terms can be applied to in-house HTS databases in identifying signature biological inhibition profiles of interest as well as expediting the assay validation process. The automated annotation of thousands of screening hits in batch is becoming feasible and has the potential to play an essential role in the hit-to-lead decision making process.

  18. Damsel: A Data Model Storage Library for Exascale Science

    Energy Technology Data Exchange (ETDEWEB)

    Choudhary, Alok [Northwestern Univ., Evanston, IL (United States); Liao, Wei-keng [Northwestern Univ., Evanston, IL (United States)

    2014-07-11

    Computational science applications have been described as having one of seven motifs (the “seven dwarfs”), each having a particular pattern of computation and communication. From a storage and I/O perspective, these applications can also be grouped into a number of data model motifs describing the way data is organized and accessed during simulation, analysis, and visualization. Major storage data models developed in the 1990s, such as Network Common Data Format (netCDF) and Hierarchical Data Format (HDF) projects, created support for more complex data models. Development of both netCDF and HDF5 was influenced by multi-dimensional dataset storage requirements, but their access models and formats were designed with sequential storage in mind (e.g., a POSIX I/O model). Although these and other high-level I/O libraries have had a beneficial impact on large parallel applications, they do not always attain a high percentage of peak I/O performance due to fundamental design limitations, and they do not address the full range of current and future computational science data models. The goal of this project is to enable exascale computational science applications to interact conveniently and efficiently with storage through abstractions that match their data models. The project consists of three major activities: (1) identifying major data model motifs in computational science applications and developing representative benchmarks; (2) developing a data model storage library, called Damsel, that supports these motifs, provides efficient storage data layouts, incorporates optimizations to enable exascale operation, and is tolerant to failures; and (3) productizing Damsel and working with computational scientists to encourage adoption of this library by the scientific community. The product of this project, Damsel library, is openly available for download from http://cucis.ece.northwestern.edu/projects/DAMSEL. Several case studies and application programming interface

  19. Linking Formal and Informal Science Education: A Successful Model using Libraries, Volunteers and NASA Resources

    Science.gov (United States)

    Race, M. S.; Lafayette Library; Learning Center Foundation (Lllcf)

    2011-12-01

    In these times of budget cuts, tight school schedules, and limited opportunities for student field trips and teacher professional development, it is especially difficult to expose elementary and middle school students to the latest STEM information-particularly in the space sciences. Using our library as a facilitator and catalyst, we built a volunteer-based, multi-faceted, curriculum-linked program for students and teachers in local middle schools (Grade 8) and showcased new astronomical and planetary science information using mainly NASA resources and volunteer effort. The project began with the idea of bringing free NASA photo exhibits (FETTU) to the Lafayette and Antioch Libraries for public display. Subsequently, the effort expanded by adding layers of activities that brought space and science information to teachers, students and the pubic at 5 libraries and schools in the 2 cities, one of which serves a diverse, underserved community. Overall, the effort (supported by a pilot grant from the Bechtel Foundation) included school and library based teacher workshops with resource materials; travelling space museum visits with hands-on activities (Chabot-to-Go); separate powerpoint presentations for students and adults at the library; and concurrent ancillary space-related themes for young children's programs at the library. This pilot project, based largely on the use of free government resources and online materials, demonstrated that volunteer-based, standards-linked STEM efforts can enhance curriculum at the middle school, with libraries serving a special role. Using this model, we subsequently also obtained a small NASA-Space Grant award to bring star parties and hand-on science activities to three libraries this Fall, linking with numerous Grade 5 teachers and students in two additional underserved areas of our county. It's not necessary to reinvent the wheel, you just collect the pieces and build on what you already have.

  20. Small RNA Library Cloning Procedure for Deep Sequencing of Specific Endogenous siRNA Classes in Caenorhabditis elegans

    Science.gov (United States)

    Ow, Maria C.; Lau, Nelson C.; Hall, Sarah E.

    2017-01-01

    In recent years, distinct classes of small RNAs ranging in size from ~21 to 26 nucleotides have been discovered and shown to play important roles in a wide array of cellular functions. Because of the abundance of these small RNAs, library preparation from an RNA sample followed by deep sequencing provides the identity and quantity of a particular class of small RNAs. In this chapter we describe a detailed protocol for preparing small RNA libraries for deep sequencing on the Illumina platform from the nematode C. elegans. PMID:24920360

  1. Object-oriented Modular Model Library for Distillation

    Institute of Scientific and Technical Information of China (English)

    CHEN Chang; DING Jianwan; CHEN Liping

    2013-01-01

    For modeling and simulation of distillation process,there are lots of special purpose simulators along with their model libraries,such as Aspen Plus and HYSYS.However,the models in these tools lack of flexibility and are not open to the end-user.Models developed in one tool can not be conveniently used in others because of the barriers among these simulators.In order to solve those problems,a flexible and extensible distillation system model library is constructed in this study,based on the Modelica and Modelica-supported platform MWorks,by the object-oriented technology and level progressive modeling strategy.It supports the reuse of knowledge on different granularities:physical phenomenon,unit model and system model.It is also an interface-friendly,accurate,fast PC-based and easily reusable simulation tool,which enables end-user to customize and extend the framework to add new functionality or adapt the simulation behavior as required.It also allows new models to be composed programmatically or graphically to form more complex models by invoking the existing components.A conventional air distillation column model is built and calculated using the library,and the results agree well with that simulated in Aspen Plus.

  2. The Managerial Roles of Academic Library Directors: The Mintzberg Model.

    Science.gov (United States)

    Moskowitz, Michael Ann

    1986-01-01

    A study based on a model developed by Henry Mintzberg examined the internal and external managerial roles of 126 New England college and university library directors. Survey results indicate that the 97 responding directors were primarily involved with internal managerial roles and work contacts. (CDD)

  3. Implementing Kuhlthau: A New Model for Library and Reference Instruction.

    Science.gov (United States)

    Isbell, Dennis; Kammerlocher, Lisa

    1998-01-01

    Summarizes Carol Kuhlthau's research on the information search process. Discusses how Kuhlthau's model of students' information search process (ISP) has been integrated into a course at Arizona State University and is being used experimentally as a training tool in the library's reference services. Selected student responses to research process…

  4. Sustaining librarian vitality: embedded librarianship model for health sciences libraries.

    Science.gov (United States)

    Wu, Lin; Mi, Misa

    2013-01-01

    With biomedical information widely accessible from anywhere at any time, health sciences libraries have become less centralized, and they are challenged to stay relevant and vital to the mission and strategic goals of their home institution. One solution is to embed librarians at strategic points in health professions' education, research, and patient care. This article discusses a proposed five-level model of embedded librarianship within the context of health sciences libraries and describes different roles, knowledge, and skills desirable for health sciences librarians working as embedded librarians.

  5. Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila.

    Directory of Open Access Journals (Sweden)

    Stephen R Spindler

    Full Text Available Protein kinase signaling cascades control most aspects of cellular function. The ATP binding domains of signaling protein kinases are the targets of most available inhibitors. These domains are highly conserved from mammals to flies. Herein we describe screening of a library of small molecule inhibitors of protein kinases for their ability to increase Drosophila lifespan. We developed an assay system which allowed screening using the small amounts of materials normally present in commercial chemical libraries. The studies identified 17 inhibitors, the majority of which targeted tyrosine kinases associated with the epidermal growth factor receptor (EGFR, platelet-derived growth factor (PDGF/vascular endothelial growth factor (VEGF receptors, G-protein coupled receptor (GPCR, Janus kinase (JAK/signal transducer and activator of transcription (STAT, the insulin and insulin-like growth factor (IGFI receptors. Comparison of the protein kinase signaling effects of the inhibitors in vitro defined a consensus intracellular signaling profile which included decreased signaling by p38MAPK (p38, c-Jun N-terminal kinase (JNK and protein kinase C (PKC. If confirmed, many of these kinases will be novel additions to the signaling cascades known to regulate metazoan longevity.

  6. Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila.

    Science.gov (United States)

    Spindler, Stephen R; Li, Rui; Dhahbi, Joseph M; Yamakawa, Amy; Sauer, Frank

    2012-01-01

    Protein kinase signaling cascades control most aspects of cellular function. The ATP binding domains of signaling protein kinases are the targets of most available inhibitors. These domains are highly conserved from mammals to flies. Herein we describe screening of a library of small molecule inhibitors of protein kinases for their ability to increase Drosophila lifespan. We developed an assay system which allowed screening using the small amounts of materials normally present in commercial chemical libraries. The studies identified 17 inhibitors, the majority of which targeted tyrosine kinases associated with the epidermal growth factor receptor (EGFR), platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) receptors, G-protein coupled receptor (GPCR), Janus kinase (JAK)/signal transducer and activator of transcription (STAT), the insulin and insulin-like growth factor (IGFI) receptors. Comparison of the protein kinase signaling effects of the inhibitors in vitro defined a consensus intracellular signaling profile which included decreased signaling by p38MAPK (p38), c-Jun N-terminal kinase (JNK) and protein kinase C (PKC). If confirmed, many of these kinases will be novel additions to the signaling cascades known to regulate metazoan longevity.

  7. Identification of ligand-target pairs from combined libraries of small molecules and unpurified protein targets in cell lysates.

    Science.gov (United States)

    McGregor, Lynn M; Jain, Tara; Liu, David R

    2014-02-26

    We describe the development and validation of interaction determination using unpurified proteins (IDUP), a method that selectively amplifies DNA sequences identifying ligand+target pairs from a mixture of DNA-linked small molecules and unpurified protein targets in cell lysates. By operating in cell lysates, IDUP preserves native post-translational modifications and interactions with endogenous binding partners, thereby enabling the study of difficult-to-purify targets and increasing the potential biological relevance of detected interactions compared with methods that require purified proteins. In IDUP, target proteins are associated with DNA oligonucleotide tags either non-covalently using a DNA-linked antibody or covalently using a SNAP-tag. Ligand-target binding promotes hybridization of a self-priming hairpin that is extended by a DNA polymerase to create a DNA strand that contains sequences identifying both the target and its ligand. These sequences encoding ligand+target pairs are selectively amplified by PCR and revealed by high-throughput DNA sequencing. IDUP can respond to the effect of affinity-modulating adaptor proteins in cell lysates that would be absent in ligand screening or selection methods using a purified protein target. This capability was exemplified by the 100-fold amplification of DNA sequences encoding FRB+rapamycin or FKBP+rapamycin in samples overexpressing both FRB and FKBP (FRB·rapamycin+FKBP, Kd ≈ 100 fM; FKBP·rapamycin+FRB, Kd = 12 nM). In contrast, these sequences were amplified 10-fold less efficiently in samples overexpressing either FRB or FKBP alone (rapamycin+FKBP, Kd ≈ 0.2 nM; rapamcyin+FRB, Kd = 26 μM). Finally, IDUP was used to process a model library of DNA-linked small molecules and a model library of cell lysates expressing SNAP-target fusions combined in a single sample. In this library×library experiment, IDUP resulted in enrichment of sequences corresponding to five known ligand+target pairs ranging in binding

  8. On Model Libraries for Thermo-hydraulic Applications

    OpenAIRE

    Eborn, Jonas

    2001-01-01

    Mathematical modelling and simulation are important tools when dealing with engineering systems that today are becoming increasingly more complex. Tightly integrated production and process optimization are trends that give rise to heterogeneous systems, which are difficult to handle without expertise in several engineering disciplines. Model libraries provide an excellent way to package engineering knowledge of systems and units to be reused by non experts. Many commercial simulation packages...

  9. Comparison of large-insert, small-insert and pyrosequencing libraries for metagenomic analysis

    OpenAIRE

    2012-01-01

    The development of DNA sequencing methods for characterizing microbial communities has evolved rapidly over the past decades. To evaluate more traditional, as well as newer methodologies for DNA library preparation and sequencing, we compared fosmid, short-insert shotgun and 454 pyrosequencing libraries prepared from the same metagenomic DNA samples. GC content was elevated in all fosmid libraries, compared with shotgun and 454 libraries. Taxonomic composition of the different libraries sugge...

  10. Biomass Scenario Model Scenario Library: Definitions, Construction, and Description

    Energy Technology Data Exchange (ETDEWEB)

    Inman, D.; Vimmerstedt, L.; Bush, B.; Peterson, S.

    2014-04-01

    Understanding the development of the biofuels industry in the United States is important to policymakers and industry. The Biomass Scenario Model (BSM) is a system dynamics model of the biomass-to-biofuels system that can be used to explore policy effects on biofuels development. Because of the complexity of the model, as well as the wide range of possible future conditions that affect biofuels industry development, we have not developed a single reference case but instead developed a set of specific scenarios that provide various contexts for our analyses. The purpose of this report is to describe the scenarios that comprise the BSM scenario library. At present, we have the following policy-focused scenarios in our library: minimal policies, ethanol-focused policies, equal access to policies, output-focused policies, technological diversity focused, and the point-of-production- focused. This report describes each scenario, its policy settings, and general insights gained through use of the scenarios in analytic studies.

  11. Jeddah Historical Building Information Modelling "JHBIM" - Object Library

    Science.gov (United States)

    Baik, A.; Alitany, A.; Boehm, J.; Robson, S.

    2014-05-01

    The theory of using Building Information Modelling "BIM" has been used in several Heritage places in the worldwide, in the case of conserving, documenting, managing, and creating full engineering drawings and information. However, one of the most serious issues that facing many experts in order to use the Historical Building Information Modelling "HBIM", is creating the complicated architectural elements of these Historical buildings. In fact, many of these outstanding architectural elements have been designed and created in the site to fit the exact location. Similarly, this issue has been faced the experts in Old Jeddah in order to use the BIM method for Old Jeddah historical Building. Moreover, The Saudi Arabian City has a long history as it contains large number of historic houses and buildings that were built since the 16th century. Furthermore, the BIM model of the historical building in Old Jeddah always take a lot of time, due to the unique of Hijazi architectural elements and no such elements library, which have been took a lot of time to be modelled. This paper will focus on building the Hijazi architectural elements library based on laser scanner and image survey data. This solution will reduce the time to complete the HBIM model and offering in depth and rich digital architectural elements library to be used in any heritage projects in Al-Balad district, Jeddah City.

  12. Use of cryopreserved cell aliquots in the high-throughput screening of small interfering RNA libraries.

    Science.gov (United States)

    Swearingen, Elissa A; Fajardo, Flordeliza; Wang, Xiangyun; Watson, J E Vivienne; Quon, Kim C; Kassner, Paul D

    2010-06-01

    Screening small interfering RNA (siRNA) libraries holds the potential to elucidate gene function as well as discover new targets for the therapeutic treatment of disease. Since the inception of siRNA as a discovery tool, there have been progressive improvements in siRNA design algorithms, the transfection reagents used to deliver them, and the assay formats used to monitor phenotypic changes. These changes have helped to improve the quality of the data emerging from siRNA screens. One variable that introduces inconsistency into high-throughput screening (HTS) of siRNA libraries is the state of the cells used in the assays. Multiple factors can contribute to differences in transfection efficiency as well as the basic cell biology, which can lead to differences in the genes identified in siRNA screens. The authors have developed a system using frozen cell aliquots to use in siRNA HTS, so that a major source of variability introduced into cell-based screens can be standardized. In addition, by transiently transfecting plasmids into cell lines and then freezing these cells down to use in siRNA transfection experiments, they have used this same technology to create new cell lines. This process of using aliquots of frozen cells is logistically advantageous in an HTS setting, as it reduces the time spent maintaining cell lines, as well as reducing possible downtime in screening due to lack of cells or poor cell health.

  13. Stochastic hyperfine interactions modeling library-Version 2

    Science.gov (United States)

    Zacate, Matthew O.; Evenson, William E.

    2016-02-01

    The stochastic hyperfine interactions modeling library (SHIML) provides a set of routines to assist in the development and application of stochastic models of hyperfine interactions. The library provides routines written in the C programming language that (1) read a text description of a model for fluctuating hyperfine fields, (2) set up the Blume matrix, upon which the evolution operator of the system depends, and (3) find the eigenvalues and eigenvectors of the Blume matrix so that theoretical spectra of experimental techniques that measure hyperfine interactions can be calculated. The optimized vector and matrix operations of the BLAS and LAPACK libraries are utilized. The original version of SHIML constructed and solved Blume matrices for methods that measure hyperfine interactions of nuclear probes in a single spin state. Version 2 provides additional support for methods that measure interactions on two different spin states such as Mössbauer spectroscopy and nuclear resonant scattering of synchrotron radiation. Example codes are provided to illustrate the use of SHIML to (1) generate perturbed angular correlation spectra for the special case of polycrystalline samples when anisotropy terms of higher order than A22 can be neglected and (2) generate Mössbauer spectra for polycrystalline samples for pure dipole or pure quadrupole transitions.

  14. Hyperopt: a Python library for model selection and hyperparameter optimization

    Science.gov (United States)

    Bergstra, James; Komer, Brent; Eliasmith, Chris; Yamins, Dan; Cox, David D.

    2015-01-01

    Sequential model-based optimization (also known as Bayesian optimization) is one of the most efficient methods (per function evaluation) of function minimization. This efficiency makes it appropriate for optimizing the hyperparameters of machine learning algorithms that are slow to train. The Hyperopt library provides algorithms and parallelization infrastructure for performing hyperparameter optimization (model selection) in Python. This paper presents an introductory tutorial on the usage of the Hyperopt library, including the description of search spaces, minimization (in serial and parallel), and the analysis of the results collected in the course of minimization. This paper also gives an overview of Hyperopt-Sklearn, a software project that provides automatic algorithm configuration of the Scikit-learn machine learning library. Following Auto-Weka, we take the view that the choice of classifier and even the choice of preprocessing module can be taken together to represent a single large hyperparameter optimization problem. We use Hyperopt to define a search space that encompasses many standard components (e.g. SVM, RF, KNN, PCA, TFIDF) and common patterns of composing them together. We demonstrate, using search algorithms in Hyperopt and standard benchmarking data sets (MNIST, 20-newsgroups, convex shapes), that searching this space is practical and effective. In particular, we improve on best-known scores for the model space for both MNIST and convex shapes. The paper closes with some discussion of ongoing and future work.

  15. PNet: A Python Library for Petri Net Modeling and Simulation

    Directory of Open Access Journals (Sweden)

    Zhu En Chay

    2016-07-01

    Full Text Available Petri Net is a formalism to describe changes between 2 or more states across discrete time and has been used to model many systems. We present PNet – a pure Python library for Petri Net modeling and simulation in Python programming language. The design of PNet focuses on reducing the learning curve needed to define a Petri Net by using a text-based language rather than programming constructs to define transition rules. Complex transition rules can be refined as regular Python functions. To demonstrate the simplicity of PNet, we present 2 examples – bread baking, and epidemiological models.

  16. Cloning of open reading frames and promoters from the Saccharomyces cerevisiae genome: construction of genomic libraries of random small fragments.

    Science.gov (United States)

    Santangelo, G M; Tornow, J; Moldave, K

    1986-01-01

    We have developed a novel efficient method, carrier-facilitated insertion, to insert small (150-600 bp) DNA fragments into plasmid vectors. This method employs a carrier segment of vector DNA to circumvent the difficulties in ligating two fragments together to generate a recombinant circle efficiently. We have used carrier-facilitated insertion to construct three genomic libraries of random (DNase I-generated) fragments from the Saccharomyces cerevisiae genome. One of these was an expression library, and the other two were promoter-cloning libraries. 87-90% of the Escherichia coli colonies in each library contained recombinant plasmids, and less than 3% of the recombinants contained more than one insert. Detection of open reading frames among the inserts in the expression library was accomplished by testing for beta-galactosidase activity. This methodology, unencumbered by the intrinsic disproportionality of cDNA libraries, can be used to identify and clone DNA that codes for a specific antigenic determinant. When used in combination with a method to detect and isolate random constitutive, repressible and inducible yeast promoters, these libraries should permit a comprehensive analysis of the yeast genome and its expression.

  17. Small is beautiful: models of small neuronal networks.

    Science.gov (United States)

    Lamb, Damon G; Calabrese, Ronald L

    2012-08-01

    Modeling has contributed a great deal to our understanding of how individual neurons and neuronal networks function. In this review, we focus on models of the small neuronal networks of invertebrates, especially rhythmically active CPG networks. Models have elucidated many aspects of these networks, from identifying key interacting membrane properties to pointing out gaps in our understanding, for example missing neurons. Even the complex CPGs of vertebrates, such as those that underlie respiration, have been reduced to small network models to great effect. Modeling of these networks spans from simplified models, which are amenable to mathematical analyses, to very complicated biophysical models. Some researchers have now adopted a population approach, where they generate and analyze many related models that differ in a few to several judiciously chosen free parameters; often these parameters show variability across animals and thus justify the approach. Models of small neuronal networks will continue to expand and refine our understanding of how neuronal networks in all animals program motor output, process sensory information and learn.

  18. Creating Library Websites with Joomla: Not Too Big, Not Too Small, Just Right

    Directory of Open Access Journals (Sweden)

    Ellen Bahr

    2010-12-01

    Full Text Available Many organizations, including libraries, are turning to content management systems to simplify the management of their websites. Alfred University‘s Herrick Memorial Library recently implemented a new website using Joomla, an open-source content management system. While Drupal has received significant attention in the library community, Joomla may be a more practical choice for some libraries. The purpose of this paper is to share our experience with Joomla so that other libraries can more easily evaluate its suitability to their environment.

  19. A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.

    Science.gov (United States)

    Joshi, Priyanka; Chia, Sean; Habchi, Johnny; Knowles, Tuomas P J; Dobson, Christopher M; Vendruscolo, Michele

    2016-03-14

    The aggregation process of intrinsically disordered proteins (IDPs) has been associated with a wide range of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. Currently, however, no drug in clinical use targets IDP aggregation. To facilitate drug discovery programs in this important and challenging area, we describe a fragment-based approach of generating small-molecule libraries that target specific IDPs. The method is based on the use of molecular fragments extracted from compounds reported in the literature to inhibit of the aggregation of IDPs. These fragments are used to screen existing large generic libraries of small molecules to form smaller libraries specific for given IDPs. We illustrate this approach by describing three distinct small-molecule libraries to target, Aβ, tau, and α-synuclein, which are three IDPs implicated in Alzheimer's and Parkinson's diseases. The strategy described here offers novel opportunities for the identification of effective molecular scaffolds for drug discovery for neurodegenerative disorders and to provide insights into the mechanism of small-molecule binding to IDPs.

  20. UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small molecule natural product libraries

    Science.gov (United States)

    Generation of natural product libraries containing column fractions, each with only a few small molecules, by a high throughput, automated fractionation system has made it possible to implement an improved dereplication strategy for selection and prioritization of hits in a natural product discovery...

  1. Universal strategies for the DNA-encoding of libraries of small molecules using the chemical ligation of oligonucleotide tags.

    Science.gov (United States)

    Litovchick, Alexander; Clark, Matthew A; Keefe, Anthony D

    2014-01-01

    The affinity-mediated selection of large libraries of DNA-encoded small molecules is increasingly being used to initiate drug discovery programs. We present universal methods for the encoding of such libraries using the chemical ligation of oligonucleotides. These methods may be used to record the chemical history of individual library members during combinatorial synthesis processes. We demonstrate three different chemical ligation methods as examples of information recording processes (writing) for such libraries and two different cDNA-generation methods as examples of information retrieval processes (reading) from such libraries. The example writing methods include uncatalyzed and Cu(I)-catalyzed alkyne-azide cycloadditions and a novel photochemical thymidine-psoralen cycloaddition. The first reading method "relay primer-dependent bypass" utilizes a relay primer that hybridizes across a chemical ligation junction embedded in a fixed-sequence and is extended at its 3'-terminus prior to ligation to adjacent oligonucleotides. The second reading method "repeat-dependent bypass" utilizes chemical ligation junctions that are flanked by repeated sequences. The upstream repeat is copied prior to a rearrangement event during which the 3'-terminus of the cDNA hybridizes to the downstream repeat and polymerization continues. In principle these reading methods may be used with any ligation chemistry and offer universal strategies for the encoding (writing) and interpretation (reading) of DNA-encoded chemical libraries.

  2. The MAPPINGS III Library of Fast Radiative Shock Models

    CERN Document Server

    Allen, Mark G; Dopita, Michael A; Sutherland, Ralph S; Kewley, Lisa J

    2008-01-01

    We present a new library of fully-radiative shock models calculated with the MAPPINGS III shock and photoionization code. The library consists of grids of models with shock velocities in the range v=100-1000 km/s and magnetic parameters B/sqrt(n) of 10^-4 - 10 muG cm^(3/2) for five different atomic abundance sets, and for a pre-shock density of 1.0 cm^(-3). Additionally, Solar abundance model grids have been calculated for densities of 0.01, 0.1, 10, 100, and 1000 cm^(-3) with the same range in v and B/sqrt(n). Each model includes components of both the radiative shock and its photoionized precursor, ionized by the EUV and soft X-ray radiation generated in the radiative gas. We present the details of the ionization structure, the column densities, and the luminosities of the shock and its precursor. Emission line ratio predictions are separately given for the shock and its precursor as well as for the composite shock+precursor structure to facilitate comparison with observations in cases where the shock and i...

  3. Comparative metabolomics reveals biogenesis of ascarosides, a modular library of small-molecule signals in C. elegans.

    Science.gov (United States)

    von Reuss, Stephan H; Bose, Neelanjan; Srinivasan, Jagan; Yim, Joshua J; Judkins, Joshua C; Sternberg, Paul W; Schroeder, Frank C

    2012-01-25

    In the model organism Caenorhabditis elegans, a family of endogenous small molecules, the ascarosides function as key regulators of developmental timing and behavior that act upstream of conserved signaling pathways. The ascarosides are based on the dideoxysugar ascarylose, which is linked to fatty-acid-like side chains of varying lengths derived from peroxisomal β-oxidation. Despite the importance of ascarosides for many aspects of C. elegans biology, knowledge of their structures, biosynthesis, and homeostasis remains incomplete. We used an MS/MS-based screen to profile ascarosides in C. elegans wild-type and mutant metabolomes, which revealed a much greater structural diversity of ascaroside derivatives than previously reported. Comparison of the metabolomes from wild-type and a series of peroxisomal β-oxidation mutants showed that the enoyl CoA-hydratase MAOC-1 serves an important role in ascaroside biosynthesis and clarified the functions of two other enzymes, ACOX-1 and DHS-28. We show that, following peroxisomal β-oxidation, the ascarosides are selectively derivatized with moieties of varied biogenetic origin and that such modifications can dramatically affect biological activity, producing signaling molecules active at low femtomolar concentrations. Based on these results, the ascarosides appear as a modular library of small-molecule signals, integrating building blocks from three major metabolic pathways: carbohydrate metabolism, peroxisomal β-oxidation of fatty acids, and amino acid catabolism. Our screen further demonstrates that ascaroside biosynthesis is directly affected by nutritional status and that excretion of the final products is highly selective.

  4. A Web-Based Electronic Book (e-book) Library: The netLibrary Model.

    Science.gov (United States)

    Connaway, Lynn Silipigni

    2001-01-01

    Identifies elements that are important for academic libraries to use in evaluating electronic books, including content; acquisition and collection development; software and hardware standards and protocols; digital rights management; access; archiving; privacy; the market and pricing; and enhancements and ideal features. Describes netLibrary, a…

  5. A Web-Based Electronic Book (e-book) Library: The netLibrary Model.

    Science.gov (United States)

    Connaway, Lynn Silipigni

    2001-01-01

    Identifies elements that are important for academic libraries to use in evaluating electronic books, including content; acquisition and collection development; software and hardware standards and protocols; digital rights management; access; archiving; privacy; the market and pricing; and enhancements and ideal features. Describes netLibrary, a…

  6. AST: A library for modelling and manipulating coordinate systems

    CERN Document Server

    Berry, David; Jenness, Tim

    2016-01-01

    In view of increased interest in object-oriented systems for describing coordinate information, we present a description of the data model used by the Starlink AST library. AST provides a comprehensive range of facilities for attaching world co-ordinate systems to astronomical data, and for retrieving and interpreting that information in a variety of formats, including FITS-WCS. AST is a mature system that has been in use for more than 17 years, and may consequently be useful as a means of informing development of similar systems in the future.

  7. Differentiated digital library evaluation in a hierarchical model stemming from its operational scope and complexity

    Institute of Scientific and Technical Information of China (English)

    WU; Jianhua; WANG; Zhaohui

    2009-01-01

    Digital libraries are complex systems and this brings difficulties for their evaluation.This paper proposes a hierarchical model to solve this problem,and puts the entangled matters into a clear-layered structure.Firstly,digital libraries(DLs thereafter)are classified into 5 groups in ascending gradations,i.e.mini DLs,small DLs,medium DLs,large DLs,and huge DLs by their scope of operation.Then,according to the characteristics of DLs at different operational scope and level of sophistication,they are further grouped into unitary DLs,union DLs and hybrid DLs accordingly.Based on this simulated structure,a hierarchical model for digital library evaluation is introduced,which evaluates DLs differentiatingly within a hierarchical scheme by using varying criteria based on their specific level of operational complexity such as at the micro-level,medium-level,and/or at the macro-level.Based on our careful examination and analysis of the current literature about DL evaluation system,an experiment is conducted by using the DL evaluation model along with its criteria for unitary DLs at micro-level.The main contents resulting from this evaluation experimentation and also those evaluation indicators and relevant issues of major concerns for DLs at medium-level and macro-level are also to be presented at some length.

  8. A computational library for multiscale modeling of material failure

    Science.gov (United States)

    Talebi, Hossein; Silani, Mohammad; Bordas, Stéphane P. A.; Kerfriden, Pierre; Rabczuk, Timon

    2014-05-01

    We present an open-source software framework called PERMIX for multiscale modeling and simulation of fracture in solids. The framework is an object oriented open-source effort written primarily in Fortran 2003 standard with Fortran/C++ interfaces to a number of other libraries such as LAMMPS, ABAQUS, LS-DYNA and GMSH. Fracture on the continuum level is modeled by the extended finite element method (XFEM). Using several novel or state of the art methods, the piece software handles semi-concurrent multiscale methods as well as concurrent multiscale methods for fracture, coupling two continuum domains or atomistic domains to continuum domains, respectively. The efficiency of our open-source software is shown through several simulations including a 3D crack modeling in clay nanocomposites, a semi-concurrent FE-FE coupling, a 3D Arlequin multiscale example and an MD-XFEM coupling for dynamic crack propagation.

  9. Rock.XML - Towards a library of rock physics models

    Science.gov (United States)

    Jensen, Erling Hugo; Hauge, Ragnar; Ulvmoen, Marit; Johansen, Tor Arne; Drottning, Åsmund

    2016-08-01

    Rock physics modelling provides tools for correlating physical properties of rocks and their constituents to the geophysical observations we measure on a larger scale. Many different theoretical and empirical models exist, to cover the range of different types of rocks. However, upon reviewing these, we see that they are all built around a few main concepts. Based on this observation, we propose a format for digitally storing the specifications for rock physics models which we have named Rock.XML. It does not only contain data about the various constituents, but also the theories and how they are used to combine these building blocks to make a representative model for a particular rock. The format is based on the Extensible Markup Language XML, making it flexible enough to handle complex models as well as scalable towards extending it with new theories and models. This technology has great advantages as far as documenting and exchanging models in an unambiguous way between people and between software. Rock.XML can become a platform for creating a library of rock physics models; making them more accessible to everyone.

  10. E-Books and New Library Service Models: An Analysis of the Impact of E-Book Technology on Academic Libraries.

    Science.gov (United States)

    Jantz, Ronald

    2001-01-01

    Analyzes the implications of electronic book technology (e-books) on academic libraries. Discusses new business models for publishers, including self-publishing, Internet publishing, and partnerships with libraries as publishers; impact on library services, including cataloging, circulation, and digital preservation; user benefits; standards;…

  11. Predicting Electrophoretic Mobility of Protein-Ligand Complexes for Ligands from DNA-Encoded Libraries of Small Molecules.

    Science.gov (United States)

    Bao, Jiayin; Krylova, Svetlana M; Cherney, Leonid T; Hale, Robert L; Belyanskaya, Svetlana L; Chiu, Cynthia H; Shaginian, Alex; Arico-Muendel, Christopher C; Krylov, Sergey N

    2016-05-17

    Selection of target-binding ligands from DNA-encoded libraries of small molecules (DELSMs) is a rapidly developing approach in drug-lead discovery. Methods of kinetic capillary electrophoresis (KCE) may facilitate highly efficient homogeneous selection of ligands from DELSMs. However, KCE methods require accurate prediction of electrophoretic mobilities of protein-ligand complexes. Such prediction, in turn, requires a theory that would be applicable to DNA tags of different structures used in different DELSMs. Here we present such a theory. It utilizes a model of a globular protein connected, through a single point (small molecule), to a linear DNA tag containing a combination of alternating double-stranded and single-stranded DNA (dsDNA and ssDNA) regions of varying lengths. The theory links the unknown electrophoretic mobility of protein-DNA complex with experimentally determined electrophoretic mobilities of the protein and DNA. Mobility prediction was initially tested by using a protein interacting with 18 ligands of various combinations of dsDNA and ssDNA regions, which mimicked different DELSMs. For all studied ligands, deviation of the predicted mobility from the experimentally determined value was within 11%. Finally, the prediction was tested for two proteins and two ligands with a DNA tag identical to those of DELSM manufactured by GlaxoSmithKline. Deviation between the predicted and experimentally determined mobilities did not exceed 5%. These results confirm the accuracy and robustness of our model, which makes KCE methods one step closer to their practical use in selection of drug leads, and diagnostic probes from DELSMs.

  12. Programming for adults a guide for small- and medium-sized libraries

    CERN Document Server

    Ranier, Raymond

    2005-01-01

    This book addresses all aspects of the programming process, from idea to execution, from crafts and entertainment to film, arts and science. Included are sources of funding, contracts and agreements, programming to meet the library's mission, and program evaluation.

  13. Discovery of small-molecule interleukin-2 inhibitors from a DNA-encoded chemical library.

    Science.gov (United States)

    Leimbacher, Markus; Zhang, Yixin; Mannocci, Luca; Stravs, Michael; Geppert, Tim; Scheuermann, Jörg; Schneider, Gisbert; Neri, Dario

    2012-06-18

    Libraries of chemical compounds individually coupled to encoding DNA tags (DNA-encoded chemical libraries) hold promise to facilitate exceptionally efficient ligand discovery. We constructed a high-quality DNA-encoded chemical library comprising 30,000 drug-like compounds; this was screened in 170 different affinity capture experiments. High-throughput sequencing allowed the evaluation of 120 million DNA codes for a systematic analysis of selection strategies and statistically robust identification of binding molecules. Selections performed against the tumor-associated antigen carbonic anhydrase IX (CA IX) and the pro-inflammatory cytokine interleukin-2 (IL-2) yielded potent inhibitors with exquisite target specificity. The binding mode of the revealed pharmacophore against IL-2 was confirmed by molecular docking. Our findings suggest that DNA-encoded chemical libraries allow the facile identification of drug-like ligands principally to any protein of choice, including molecules capable of disrupting high-affinity protein-protein interactions.

  14. 基于小数据的图书馆个性化服务QOS保证研究%Research on QOS Guarantee for Personalized Services of Library Based on Small Data

    Institute of Scientific and Technical Information of China (English)

    陈臣

    2015-01-01

    为了解决图书馆个性化服务质量保证的相关问题,提出一种基于小数据的图书馆个性化服务模式.该模式实现了图书馆的精准营销,保证CRM系统以客户为中心,可为图书馆的个性化服务服务质量(QOS)保证提供有力支撑.%In order to deal with the QOS guarantee for personalized services of library, in this paper, a library personalized service model based on small date is presented. The model can guarantee precision marketing of library, guarantee CRM implements among the customer, and can give a strong support for QOS guarantee of library.

  15. SRADLIB: A C Library for Solar Radiation Modelling

    Energy Technology Data Exchange (ETDEWEB)

    Balenzategui, J. L. [Ciemat. Madrid (Spain)

    2000-07-01

    This document shows the result of an exhaustive study about the theoretical and numerical models available in the literature about solar radiation modelling. The purpose of this study is to develop or adapt mathematical models describing the solar radiation specifically for Spain locations as well as to create computer tools able to support the labour of researchers or engineers needing solar radiation data to solve or improve the technical or energetic performance of solar systems. As results of this study and revision, a C library (SRADLIB) is presented as a key for the compilation of the mathematical models from different authors, for the comparison among the different approaches and for its application in computer programs. Different topics related to solar radiation and its modelling are first discussed, including the assumptions and conventions adopted and describing the most accepted and used current state-of-the-art models. some typical problems in the numerical calculation of radiation values are also posed with the proposed solution. The document includes next a complete reference of the developed functions, with many examples of application and calculus. (Author) 24 refs.

  16. Selection of DNA-encoded small molecule libraries against unmodified and non-immobilized protein targets.

    Science.gov (United States)

    Zhao, Peng; Chen, Zitian; Li, Yizhou; Sun, Dawei; Gao, Yuan; Huang, Yanyi; Li, Xiaoyu

    2014-09-15

    The selection of DNA-encoded libraries against biological targets has become an important discovery method in chemical biology and drug discovery, but the requirement of modified and immobilized targets remains a significant disadvantage. With a terminal protection strategy and ligand-induced photo-crosslinking, we show that iterated selections of DNA-encoded libraries can be realized with unmodified and non-immobilized protein targets.

  17. Expedient preparation of nazlinine and a small library of indole alkaloids using flow electrochemistry as an enabling technology.

    Science.gov (United States)

    Kabeshov, Mikhail A; Musio, Biagia; Murray, Philip R D; Browne, Duncan L; Ley, Steven V

    2014-09-05

    An expedient synthesis of the indole alkaloid nazlinine is reported. Judicious choice of flow electrochemistry as an enabling technology has permitted the rapid generation of a small library of unnatural relatives of this biologically active molecule. Furthermore, by conducting the key electrochemical Shono oxidation in a flow cell, the loading of electrolyte can be significantly reduced to 20 mol % while maintaining a stable, broadly applicable process.

  18. Discussion about the Realization of Smart Library in Mediurn and Small Scale Library%论智慧图书馆在中小型图书馆中的实现

    Institute of Scientific and Technical Information of China (English)

    唐水铭

    2013-01-01

    In this paper ,start from the basic knowledge of smart library ,thinking the advantages and disadvantages of smart li-brary construction in medium and small scale library ,and then based on the concept ,management ,material ,technology ,service five aspects ,explored the problem which smart library in the medium and small scale library how to realize .%本文从智慧图书馆的基本认识入手,思考了中小型图书馆构建智慧图书馆的优势与劣势,并在此基础上从理念、管理、物质、技术、服务五个层面探讨了智慧图书馆在中小型图书馆中如何实现的问题。

  19. A Model for Designing Library Instruction for Distance Learning

    Science.gov (United States)

    Rand, Angela Doucet

    2013-01-01

    Providing library instruction in distance learning environments presents a unique set of challenges for instructional librarians. Innovations in computer-mediated communication and advances in cognitive science research provide the opportunity for designing library instruction that meets a variety of student information seeking needs. Using a…

  20. A Model for Designing Library Instruction for Distance Learning

    Science.gov (United States)

    Rand, Angela Doucet

    2013-01-01

    Providing library instruction in distance learning environments presents a unique set of challenges for instructional librarians. Innovations in computer-mediated communication and advances in cognitive science research provide the opportunity for designing library instruction that meets a variety of student information seeking needs. Using a…

  1. An Information Access Model at a Distant Branch Library

    Science.gov (United States)

    Stratton, John M.

    2004-01-01

    Academic branch libraries located at a distance from the parent institution often face unique challenges in meeting users' needs for scholarly information. This is especially true for distant branch libraries that do not have a specialized function or collection, but who often face the challenge of meeting users' needs for scholarly materials…

  2. Using the gini coefficient to measure the chemical diversity of small-molecule libraries.

    Science.gov (United States)

    Weidlich, Iwona E; Filippov, Igor V

    2016-08-15

    Modern databases of small organic molecules contain tens of millions of structures. The size of theoretically available chemistry is even larger. However, despite the large amount of chemical information, the "big data" moment for chemistry has not yet provided the corresponding payoff of cheaper computer-predicted medicine or robust machine-learning models for the determination of efficacy and toxicity. Here, we present a study of the diversity of chemical datasets using a measure that is commonly used in socioeconomic studies. We demonstrate the use of this diversity measure on several datasets that were constructed to contain various congeneric subsets of molecules as well as randomly selected molecules. We also apply our method to a number of well-known databases that are frequently used for structure-activity relationship modeling. Our results show the poor diversity of the common sources of potential lead compounds compared to actual known drugs. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  3. Open resource metagenomics: a model for sharing metagenomic libraries.

    Science.gov (United States)

    Neufeld, J D; Engel, K; Cheng, J; Moreno-Hagelsieb, G; Rose, D R; Charles, T C

    2011-11-30

    Both sequence-based and activity-based exploitation of environmental DNA have provided unprecedented access to the genomic content of cultivated and uncultivated microorganisms. Although researchers deposit microbial strains in culture collections and DNA sequences in databases, activity-based metagenomic studies typically only publish sequences from the hits retrieved from specific screens. Physical metagenomic libraries, conceptually similar to entire sequence datasets, are usually not straightforward to obtain by interested parties subsequent to publication. In order to facilitate unrestricted distribution of metagenomic libraries, we propose the adoption of open resource metagenomics, in line with the trend towards open access publishing, and similar to culture- and mutant-strain collections that have been the backbone of traditional microbiology and microbial genetics. The concept of open resource metagenomics includes preparation of physical DNA libraries, preferably in versatile vectors that facilitate screening in a diversity of host organisms, and pooling of clones so that single aliquots containing complete libraries can be easily distributed upon request. Database deposition of associated metadata and sequence data for each library provides researchers with information to select the most appropriate libraries for further research projects. As a starting point, we have established the Canadian MetaMicroBiome Library (CM(2)BL [1]). The CM(2)BL is a publicly accessible collection of cosmid libraries containing environmental DNA from soils collected from across Canada, spanning multiple biomes. The libraries were constructed such that the cloned DNA can be easily transferred to Gateway® compliant vectors, facilitating functional screening in virtually any surrogate microbial host for which there are available plasmid vectors. The libraries, which we are placing in the public domain, will be distributed upon request without restriction to members of both the

  4. Building Component Library: An Online Repository to Facilitate Building Energy Model Creation; Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Fleming, K.; Long, N.; Swindler, A.

    2012-05-01

    This paper describes the Building Component Library (BCL), the U.S. Department of Energy's (DOE) online repository of building components that can be directly used to create energy models. This comprehensive, searchable library consists of components and measures as well as the metadata which describes them. The library is also designed to allow contributors to easily add new components, providing a continuously growing, standardized list of components for users to draw upon.

  5. Solid-Phase Synthesis of Small Molecule Libraries using Double Combinatorial Chemistry

    DEFF Research Database (Denmark)

    Nielsen, John; Jensen, Flemming R.

    1997-01-01

    The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can...

  6. Online Searching in the Small College Library--Ten Years Later.

    Science.gov (United States)

    Smith, Scott; Smith, Jane B.

    1991-01-01

    Reviews experiences with online searching at the Nazareth College library. Topics discussed include user expectations; actual and perceived search quality; the impact of laser printers; growth in online searching; increases in other reference services; the use of CD-ROM technology; and costs and pricing policies. (LRW)

  7. The Decline of Print: Ten Years of Print Serial Use in a Small Academic Medical Library

    Science.gov (United States)

    Rosati, Karen Thompson

    2006-01-01

    Tracking use of print journals over a ten-year period has allowed The University of South Carolina (USC) School of Medicine Library an essential tool for more accurate collection development, for both print and electronic selection. This lengthy study has provided usage statistics for purchasing decisions regarding electronic subscriptions still…

  8. Differential representation of sunflower ESTs in enriched organ-specific cDNA libraries in a small scale sequencing project

    Directory of Open Access Journals (Sweden)

    Heinz Ruth A

    2003-09-01

    Full Text Available Abstract Background Subtractive hybridization methods are valuable tools for identifying differentially regulated genes in a given tissue avoiding redundant sequencing of clones representing the same expressed genes, maximizing detection of low abundant transcripts and thus, affecting the efficiency and cost effectiveness of small scale cDNA sequencing projects aimed to the specific identification of useful genes for breeding purposes. The objective of this work is to evaluate alternative strategies to high-throughput sequencing projects for the identification of novel genes differentially expressed in sunflower as a source of organ-specific genetic markers that can be functionally associated to important traits. Results Differential organ-specific ESTs were generated from leaf, stem, root and flower bud at two developmental stages (R1 and R4. The use of different sources of RNA as tester and driver cDNA for the construction of differential libraries was evaluated as a tool for detection of rare or low abundant transcripts. Organ-specificity ranged from 75 to 100% of non-redundant sequences in the different cDNA libraries. Sequence redundancy varied according to the target and driver cDNA used in each case. The R4 flower cDNA library was the less redundant library with 62% of unique sequences. Out of a total of 919 sequences that were edited and annotated, 318 were non-redundant sequences. Comparison against sequences in public databases showed that 60% of non-redundant sequences showed significant similarity to known sequences. The number of predicted novel genes varied among the different cDNA libraries, ranging from 56% in the R4 flower to 16 % in the R1 flower bud library. Comparison with sunflower ESTs on public databases showed that 197 of non-redundant sequences (60% did not exhibit significant similarity to previously reported sunflower ESTs. This approach helped to successfully isolate a significant number of new reported sequences

  9. Safe production model for small mines

    Institute of Scientific and Technical Information of China (English)

    Calizaya F.; Suryanto S.

    2008-01-01

    Presented a "safe production model" that can be adopted by small mine opera-tors to achieve their production targets safely and efficiently. The model consists of eightelements ranging from management commitment and leadership to safety account-abilityand communication. The model is developed considering the mine operators' resourcelimitations and the workers' training needs. The study concludes with a summary of asample survey that is conducted to validate the model and estimate a parameter for eachmine and determine its position in the safe production scale.

  10. Ab initio modeling of small proteins by iterative TASSER simulations

    Directory of Open Access Journals (Sweden)

    Zhang Yang

    2007-05-01

    Full Text Available Abstract Background Predicting 3-dimensional protein structures from amino-acid sequences is an important unsolved problem in computational structural biology. The problem becomes relatively easier if close homologous proteins have been solved, as high-resolution models can be built by aligning target sequences to the solved homologous structures. However, for sequences without similar folds in the Protein Data Bank (PDB library, the models have to be predicted from scratch. Progress in the ab initio structure modeling is slow. The aim of this study was to extend the TASSER (threading/assembly/refinement method for the ab initio modeling and examine systemically its ability to fold small single-domain proteins. Results We developed I-TASSER by iteratively implementing the TASSER method, which is used in the folding test of three benchmarks of small proteins. First, data on 16 small proteins (α-root mean square deviation (RMSD of 3.8Å, with 6 of them having a Cα-RMSD α-RMSD α-RMSD of the I-TASSER models was 3.9Å, whereas it was 5.9Å using TOUCHSTONE-II software. Finally, 20 non-homologous small proteins (α-RMSD of 3.9Å was obtained for the third benchmark, with seven cases having a Cα-RMSD Conclusion Our simulation results show that I-TASSER can consistently predict the correct folds and sometimes high-resolution models for small single-domain proteins. Compared with other ab initio modeling methods such as ROSETTA and TOUCHSTONE II, the average performance of I-TASSER is either much better or is similar within a lower computational time. These data, together with the significant performance of automated I-TASSER server (the Zhang-Server in the 'free modeling' section of the recent Critical Assessment of Structure Prediction (CASP7 experiment, demonstrate new progresses in automated ab initio model generation. The I-TASSER server is freely available for academic users http://zhang.bioinformatics.ku.edu/I-TASSER.

  11. Fidelity by design: Yoctoreactor and binder trap enrichment for small-molecule DNA-encoded libraries and drug discovery.

    Science.gov (United States)

    Blakskjaer, Peter; Heitner, Tara; Hansen, Nils Jakob Vest

    2015-06-01

    DNA-encoded small-molecule library (DEL) technology allows vast drug-like small molecule libraries to be efficiently synthesized in a combinatorial fashion and screened in a single tube method for binding, with an assay readout empowered by advances in next generation sequencing technology. This approach has increasingly been applied as a viable technology for the identification of small-molecule modulators to protein targets and as precursors to drugs in the past decade. Several strategies for producing and for screening DELs have been devised by both academic and industrial institutions. This review highlights some of the most significant and recent strategies along with important results. A special focus on the production of high fidelity DEL technologies with the ability to eliminate screening noise and false positives is included: using a DNA junction called the Yoctoreactor, building blocks (BBs) are spatially confined at the center of the junction facilitating both the chemical reaction between BBs and encoding of the synthetic route. A screening method, known as binder trap enrichment, permits DELs to be screened robustly in a homogeneous manner delivering clean data sets and potent hits for even the most challenging targets.

  12. Using 4P Marketing Model in Academic Libraries: An Experience

    National Research Council Canada - National Science Library

    Mehdi Alipour Hafezi; Hassan Ashrafi Rizi; Zahra Kazempour; Mahri Shahbazi

    2013-01-01

    The present study mainly aims to demonstrate the weaknesses and strengths of using marketing principles in academic libraries and finally presenting some important suggestions in order to improve their marketing...

  13. Construction and sequence sampling of deep-coverage, large-insert BAC libraries for three model lepidopteran species

    Directory of Open Access Journals (Sweden)

    Zhao Shaying

    2009-06-01

    Full Text Available Abstract Background Manduca sexta, Heliothis virescens, and Heliconius erato represent three widely-used insect model species for genomic and fundamental studies in Lepidoptera. Large-insert BAC libraries of these insects are critical resources for many molecular studies, including physical mapping and genome sequencing, but not available to date. Results We report the construction and characterization of six large-insert BAC libraries for the three species and sampling sequence analysis of the genomes. The six BAC libraries were constructed with two restriction enzymes, two libraries for each species, and each has an average clone insert size ranging from 152–175 kb. We estimated that the genome coverage of each library ranged from 6–9 ×, with the two combined libraries of each species being equivalent to 13.0–16.3 × haploid genomes. The genome coverage, quality and utility of the libraries were further confirmed by library screening using 6~8 putative single-copy probes. To provide a first glimpse into these genomes, we sequenced and analyzed the BAC ends of ~200 clones randomly selected from the libraries of each species. The data revealed that the genomes are AT-rich, contain relatively small fractions of repeat elements with a majority belonging to the category of low complexity repeats, and are more abundant in retro-elements than DNA transposons. Among the species, the H. erato genome is somewhat more abundant in repeat elements and simple repeats than those of M. sexta and H. virescens. The BLAST analysis of the BAC end sequences suggested that the evolution of the three genomes is widely varied, with the genome of H. virescens being the most conserved as a typical lepidopteran, whereas both genomes of H. erato and M. sexta appear to have evolved significantly, resulting in a higher level of species- or evolutionary lineage-specific sequences. Conclusion The high-quality and large-insert BAC libraries of the insects, together

  14. Equalizing Access to Electronic Networked Resources: A Model for Rural Libraries in the United States.

    Science.gov (United States)

    Senkevitch, Judith J.; Wolfram, Dietmar

    1994-01-01

    Provides an overview of the current state of networking technology in rural libraries and describes a model for educating rural librarians in accessing electronic networks. Topics discussed include information needs in rural libraries; telecommunications technology access in rural areas; and examples of services to enhance information access.…

  15. An Analysis of Academic Research Libraries Assessment Data: A Look at Professional Models and Benchmarking Data

    Science.gov (United States)

    Lewin, Heather S.; Passonneau, Sarah M.

    2012-01-01

    This research provides the first review of publicly available assessment information found on Association of Research Libraries (ARL) members' websites. After providing an overarching review of benchmarking assessment data, and of professionally recommended assessment models, this paper examines if libraries contextualized their assessment…

  16. Development of microsatellite markers for common bean (Phaseolus vulgaris L.) based on screening of non-enriched, small-insert genomic libraries.

    Science.gov (United States)

    Blair, Matthew W; Torres, Monica Muñoz; Pedraza, Fabio; Giraldo, Martha C; Buendía, Hector F; Hurtado, Natalia

    2009-09-01

    Microsatellite markers are useful genetic tools for a wide array of genomic analyses although their development is time-consuming and requires the identification of simple sequence repeats (SSRs) from genomic sequences. Screening of non-enriched, small-insert libraries is an effective method of SSR isolation that can give an unbiased picture of motif frequency. Here we adapt high-throughput protocols for the screening of plasmid-based libraries using robotic colony picking and filter preparation. Seven non-enriched genomic libraries from common bean genomic DNA were made by digestion with four frequently cutting restriction enzymes, double digestion with a frequently cutting restriction enzyme and a less frequently cutting restriction enzyme, or sonication. Library quality was compared and three of the small-insert libraries were selected for further analysis. Each library was plated and picked into 384-well plates that were used to create high-density filter arrays of over 18 000 clones each, which were screened with oligonucleotide probes for various SSR motifs. Positive clones were found to have low redundancy. One hundred SSR markers were developed and 80 were tested for polymorphism in a standard parental survey. These microsatellite markers derived from non-SSR-enriched libraries should be useful additions to previous markers developed from enriched libraries.

  17. A Comprehensive Library of X-Ray Pulsars in the Small Magellanic Cloud: Time Evolution of Their Luminosities and Spin Periods

    Science.gov (United States)

    Yang, J.; Laycock, S. G. T.; Christodoulou, D. M.; Fingerman, S.; Coe, M. J.; Drake, J. J.

    2017-04-01

    We have collected and analyzed the complete archive of XMM-Newton (116), Chandra (151), and RXTE (952) observations of the Small Magellanic Cloud (SMC), spanning 1997-2014. The resulting observational library provides a comprehensive view of the physical, temporal, and statistical properties of the SMC pulsar population across the luminosity range of {L}X={10}31.2{--}{10}38 erg s-1. From a sample of 65 pulsars we report ˜1654 individual pulsar detections, yielding ˜1260 pulse-period measurements. Our pipeline generates a suite of products for each pulsar detection: spin period, flux, event list, high time-resolution light curve, pulse profile, periodogram, and spectrum. Combining all three satellites, we generated complete histories of the spin periods, pulse amplitudes, pulsed fractions, and X-ray luminosities. Some pulsars show variations in pulse period due to the combination of orbital motion and accretion torques. Long-term spin-up/spin-down trends are seen in 12/11 pulsars, respectively, pointing to sustained transfer of mass and angular momentum to the neutron star on decadal timescales. Of the sample, 30 pulsars have a relatively very small spin period derivative and may be close to equilibrium spin. The distributions of pulse detection and flux as functions of spin period provide interesting findings: mapping boundaries of accretion-driven X-ray luminosity and showing that fast pulsars (P public release of the library so that it can be used by other researchers. We intend the library to be useful in driving improved models of neutron star magnetospheres and accretion physics.

  18. Damage modeling in Small Punch Test specimens

    DEFF Research Database (Denmark)

    Martínez Pañeda, Emilio; Cuesta, I.I.; Peñuelas, I.

    2016-01-01

    Ductile damage modeling within the Small Punch Test (SPT) is extensively investigated. The capabilities ofthe SPT to reliably estimate fracture and damage properties are thoroughly discussed and emphasis isplaced on the use of notched specimens. First, different notch profiles are analyzed...... and constraint conditionsquantified. The role of the notch shape is comprehensively examined from both triaxiality and notchfabrication perspectives. Afterwards, a methodology is presented to extract the micromechanical-basedductile damage parameters from the load-displacement curve of notched SPT samples...

  19. Small Signal Circuit Model of Double Photodiodes

    Institute of Scientific and Technical Information of China (English)

    HAN Jian-zhong; Ni Guo-qiang; MAO Lu-hong

    2004-01-01

    The transmission delay of photogenerated carriers in a CMOS-process-compatible double photodiode (DPD) is analyzed by using device simulation. The DPD small signal equivalent circuit model which includes transmission delay of photogenerated carriers is given. From analysis on the frequency domain of the circuit model the device has two poles. One has the relationship with junction capacitance and the DPD's load,the other with the depth and the doping concentration of the N-well in the DPD. Different depth of the Nwell and different area of the DPDs with bandwidth were compared. The analysis results are important to design the high speed DPDs.

  20. Screening a Commercial Library of Pharmacologically Active Small Molecules against Staphylococcus aureus Biofilms.

    Science.gov (United States)

    Torres, Nelson S; Abercrombie, Johnathan J; Srinivasan, Anand; Lopez-Ribot, Jose L; Ramasubramanian, Anand K; Leung, Kai P

    2016-10-01

    It is now well established that bacterial infections are often associated with biofilm phenotypes that demonstrate increased resistance to common antimicrobials. Further, due to the collective attrition of new antibiotic development programs by the pharmaceutical industries, drug repurposing is an attractive alternative. In this work, we screened 1,280 existing commercially available drugs in the Prestwick Chemical Library, some with previously unknown antimicrobial activity, against Staphylococcus aureus, one of the commonly encountered causative pathogens of burn and wound infections. From the primary screen of the entire Prestwick Chemical Library at a fixed concentration of 10 μM, 104 drugs were found to be effective against planktonic S. aureus strains, and not surprisingly, these were mostly antimicrobials and antiseptics. The activity of 18 selected repurposing candidates, that is, drugs that show antimicrobial activity that are not already considered antimicrobials, observed in the primary screen was confirmed in dose-response experiments. Finally, a subset of nine of these drug candidates was tested against preformed biofilms of S. aureus We found that three of these drugs, niclosamide, carmofur, and auranofin, possessed antimicrobial activity against preformed biofilms, making them attractive candidates for repurposing as novel antibiofilm therapies.

  1. Transaction Analysis of Interactions at the Reference Desk of a Small Academic Library

    Directory of Open Access Journals (Sweden)

    Heather Empey

    2011-01-01

    Full Text Available As discussions continue about the changing nature of reference service in academic libraries, the Geoffrey R. Weller Library determined that more detailed information on what was happening at the Reference Desk was needed. During the 2006/07 academic year, transactions at the Reference Desk were analyzed to determine when they occurred (both during the week and during the academic year, the length of time the transactions took, the categories of the transactions, what sources were used and whether or not instruction was provided as part of the transaction. Another round of data was gathered in September 2009 to determine if use patterns had changed. Transactions at the Reference Desk were generally conducted in person, took either <1 min. or between 1-5 min. to answer, and occurred most often on Mon-Thurs between 11am-5pm. Between September 2006 and September 2009, specific title and research categories of questions decreased by 6% and directional and technical help categories of questions increased by 9%. There was also a decrease in the level of instruction being given. As a result of this research, service hours have been reduced and the on-going data collection at the Reference Desk has become more detailed to allow for ongoing analysis.

  2. A cost-effective method for Illumina small RNA-Seq library preparation using T4 RNA ligase 1 adenylated adapters

    Directory of Open Access Journals (Sweden)

    Chen Yun-Ru

    2012-09-01

    Full Text Available Abstract Background Deep sequencing is a powerful tool for novel small RNA discovery. Illumina small RNA sequencing library preparation requires a pre-adenylated 3’ end adapter containing a 5’,5’-adenyl pyrophosphoryl moiety. In the absence of ATP, this adapter can be ligated to the 3’ hydroxyl group of small RNA, while RNA self-ligation and concatenation are repressed. Pre-adenylated adapters are one of the most essential and costly components required for library preparation, and few are commercially available. Results We demonstrate that DNA oligo with 5’ phosphate and 3’ amine groups can be enzymatically adenylated by T4 RNA ligase 1 to generate customized pre-adenylated adapters. We have constructed and sequenced a small RNA library for tomato (Solanum lycopersicum using the T4 RNA ligase 1 adenylated adapter. Conclusion We provide an efficient and low-cost method for small RNA sequencing library preparation, which takes two days to complete and costs around $20 per library. This protocol has been tested in several plant species for small RNA sequencing including sweet potato, pepper, watermelon, and cowpea, and could be readily applied to any RNA samples.

  3. The National Resource Library for Science and Technology in Sweden: A Nordic model of cooperating technology libraries

    Science.gov (United States)

    Lagar, Gunnar

    1994-01-01

    The scope of this presentation is to give a state-of-the-art report on the present situation of Nordic technology libraries, to elaborate on a plan for national resource libraries in Sweden, and to share how the Royal Institute of Technology Library in Stockholm (KTHB) has fostered a network of cooperating libraries in order to optimize government funding for the system of resource libraries.

  4. Six Degrees of Information Seeking: Stanley Milgram and the Small World of the Library

    Science.gov (United States)

    James, Kathryn

    2006-01-01

    Stanley Milgram's 1967 "small world" social connectivity study is used to analyze information connectivity, or patron information-seeking behavior. The "small world" study, upon examination, offers a clear example of the failure of social connectivity. This failure is used to highlight the importance of the subjectivities of patron experience of…

  5. Human Factors of Queuing: A Library Circulation Model.

    Science.gov (United States)

    Mansfield, Jerry W.

    1981-01-01

    Classical queuing theories and their accompanying service facilities totally disregard the human factors in the name of efficiency. As library managers we need to be more responsive to human needs in the design of service points and make every effort to minimize queuing and queue frustration. Five references are listed. (Author/RAA)

  6. Servant-Leadership as a Model for Library Administration.

    Science.gov (United States)

    Doncevic, John

    2003-01-01

    Discussion of the need for library administration to change from traditional methods based on power and competition focuses on the concept of servant-leadership. Explains characteristics of a servant-leader, including being authentic, being present, being vulnerable and choosing appropriate responses, being accepting, and being useful. (LRW)

  7. High-throughput screening of small molecule libraries using SAMDI mass spectrometry.

    Science.gov (United States)

    Gurard-Levin, Zachary A; Scholle, Michael D; Eisenberg, Adam H; Mrksich, Milan

    2011-07-11

    High-throughput screening is a common strategy used to identify compounds that modulate biochemical activities, but many approaches depend on cumbersome fluorescent reporters or antibodies and often produce false-positive hits. The development of "label-free" assays addresses many of these limitations, but current approaches still lack the throughput needed for applications in drug discovery. This paper describes a high-throughput, label-free assay that combines self-assembled monolayers with mass spectrometry, in a technique called SAMDI, as a tool for screening libraries of 100,000 compounds in one day. This method is fast, has high discrimination, and is amenable to a broad range of chemical and biological applications.

  8. An Analytical Model for Service Profile Based Service Quality of an Institutional eLibrary

    CERN Document Server

    Abbas, Ash Mohammad

    2011-01-01

    Devising a scheme for evaluating the service quality of an institutional electronic library is a difficult and challenging task. The challenge comes from the fact that the services provided by an institutional electronic library depend upon the contents requested by the users and the contents housed by the library. Different types of users might be interested in different types of contents. In this paper, we propose a technique for evaluating the service quality of an institutional electronic library. Our scheme is based on the service profiles of contents requested by the users at the server side which is hosted at the library. Further, we propose models to analyze the service quality of an electronic library. For analyzing the service quality, we present two analytical models. The first one is based on the number of days by which the item to be served by the library is delayed and the penalty points per day for the duration for which the item is delayed. The second model is based on the credits earned by th...

  9. Bias in ligation-based small RNA sequencing library construction is determined by adaptor and RNA structure.

    Directory of Open Access Journals (Sweden)

    Ryan T Fuchs

    Full Text Available High-throughput sequencing (HTS has become a powerful tool for the detection of and sequence characterization of microRNAs (miRNA and other small RNAs (sRNA. Unfortunately, the use of HTS data to determine the relative quantity of different miRNAs in a sample has been shown to be inconsistent with quantitative PCR and Northern Blot results. Several recent studies have concluded that the major contributor to this inconsistency is bias introduced during the construction of sRNA libraries for HTS and that the bias is primarily derived from the adaptor ligation steps, specifically where single stranded adaptors are sequentially ligated to the 3' and 5'-end of sRNAs using T4 RNA ligases. In this study we investigated the effects of ligation bias by using a pool of randomized ligation substrates, defined mixtures of miRNA sequences and several combinations of adaptors in HTS library construction. We show that like the 3' adaptor ligation step, the 5' adaptor ligation is also biased, not because of primary sequence, but instead due to secondary structures of the two ligation substrates. We find that multiple secondary structural factors influence final representation in HTS results. Our results provide insight about the nature of ligation bias and allowed us to design adaptors that reduce ligation bias and produce HTS results that more accurately reflect the actual concentrations of miRNAs in the defined starting material.

  10. A Library of known X-ray Pulsars in the Small Magellanic Cloud: Time Evolution of their Luminosities and Spin Periods

    Science.gov (United States)

    Yang, Jun; Laycock, Silas; Christodoulou, Dimitris; Drake, Jeremy J.; Hong, Jaesub; Antoniou, Vallia; Zezas, Andreas; Coe, Malcolm; Ho, Wynn

    2017-01-01

    We have collected and analyzed 116 {\\itshape XMM-Newton\\/}, 151 {\\itshape Chandra\\/}, and 952 {\\itshape RXTE\\/} observations of the Small Magellanic Cloud (SMC), spanning 1997-2014. The resulting observational library provides a comprehensive view of the physical, temporal and statistical properties of the SMC pulsar population across the luminosity range of $L_X= 10^{31.5}-10^{38}$~erg~s$^{-1}$. We report $\\sim$1600 individual pulsar detections, yielding $\\sim$1300 pulse period measurements. Our pipeline generates a suite of products for each pulsar detection: period, flux, event list, high time-resolution light-curve, pulse-profile, periodogram and X-ray spectrum. Upper-limits are estimated for all non-detections bringing the combined database to $\\sim$37,000 observations of 67 pulsars. Combining all three satellites, we generated complete histories of the spin periods, pulse amplitudes, pulse fractions and X-ray luminosities. Many of the pulsars show variations in pulse period due to the combination of orbital motion and accretion torques. Long-term spin-up/down trends are seen in 27/25 pulsars respectively, pointing to sustained transfer of mass and angular momentum to the neutron star on decadal timescales. The distributions of pulse-detection and flux as functions of spin-period provide interesting findings: mapping boundaries of accretion-driven X-ray luminosity, and showing that fast pulsars ($Prarely detected, yet are more prone to giant outburst. Accompanying this paper is an initial public release of the library so that it can be used by other researchers. We intend the database and pulse profile library to be useful in driving improved models of neutron star magnetospheres and accretion physics.

  11. Business Model Innovation for Small Medium Enterprises

    Directory of Open Access Journals (Sweden)

    Wirania Swasty

    2015-09-01

    Full Text Available Indonesian economy through Small Medium Enterprises (SMEs is expected to absorb labor and contribute to the growth of Gross Domestic Product. However, SMEs lack both managerial and technical skills. This research is about business model innovation for SMEs especially in fashion and garment industry. Study used qualitative approach by mentoring four selected SMEs in Babakan Penghulu Village– Cinambo Sub-District, Eastern Bandung. The tools used to analyze them including PEST analysis, Porter’s Five Forces,Resource Based View, Value Chain Analysis and Business Model Canvas. Finding suggests SMEs to have business model innovation derived from value proposition. SMEs should build their own brand awareness. Moreover, as garment and fashion industry, design can be a particularly important part of the Value Proposition. SMEs could communicate its value propositions and inform their service through its official websites and other social media. Since the intangible resources include brand and design, thus SMEs should build brand image and innovate year by year. SMEs must hire designers and launch a series of new products offers under the signature of their own brands. Ideation to strengthen strategies derives from value proposition building block as a starting point. Moreover, Business Model Canvas makes strategy more focused and measurable. Business model innovation is expected to increase overall performance of SMEs.

  12. Hydrological Modelling of Small Catchments Using Swat

    Science.gov (United States)

    Kannan, N.; White, S. M.; Worrall, F.; Groves, S.

    The data from a 142ha catchment in Eastern England(Colworth, Bedfordshire)are be- ing used to investigate the performance of the USDA SWAT software for modelling hydrology of small catchments. Stream flow at the catchment outlet has been mon- itored since October 1999. About 50% of the total catchment is directly controlled within one farm and a rotation of wheat, oil seed rape, grass, linseed, beans and peas is grown. Three years of stream flow and climate data are available. Calibration and validation of stream flow was carried out with both runoff modelling options in the SWAT model (USDA curve number method and the Green and Ampt method). The Nash and Sutcliffe efficiencies for the calibration period were 66% and 63% respec- tively. The performance of SWAT was better in the validation period as a whole, with regard to timing of peaks, baseflow values and Nash and Sutcliffe efficiency. An ef- ficiency of 70% was obtained using the curve number method, which is comparable with the efficiencies obtainable with more complex models. Despite this performance, SWAT is under predicting stream flow peaks. A detailed investigation of important model components, has allowed us to identify some of the reasons for under predic- tion of stream flow peaks.

  13. A Microfluidic Platform for High-Throughput Screening of Small Mutant Libraries.

    Science.gov (United States)

    Lim, Ji Won; Shin, Kwang Soo; Moon, Jaemin; Lee, Sung Kuk; Kim, Taesung

    2016-05-17

    The screening and isolation of target microorganisms from mutated recombinant libraries are crucial for the advancement of synthetic biology and metabolic engineering. However, conventional screening tools present several limitations in throughput, cost, and labor. Herein, we describe a novel microfluidic high-throughput screening (HTS) platform with several advantages. The platform utilizes a fluid array to compartmentalize bacterial cells in well-ordered separated microwells and allows long-term cell culture with high throughput. The platform enables the extraction of selected target cells from the fluid array for additional culture and postanalysis by using a capillary-driven sample relocation method. To confirm the feasibility of the platform, we demonstrated two different types of HTS methods based on the levels of reporter gene expression and cellular growth rate difference. For the reporter gene-based HTS, a spike recovery approach was taken to demonstrate that target cells are successfully screened out from a mixture containing nontarget cells by repeating the culture and extraction processes. Additionally, the same platform allowed us to screen and sort target cells according to their cellular growth rate difference, which seems hard in conventional screening methods. Hence, the platform could be used for various microbiological assays, including the detection of cell-excreted metabolites, microbial biosensors, and other HTS systems.

  14. Portuguese School Libraries Evaluation Model: An Analysis of Primary Schools' Results for the "Reading and Literacy" Domain

    Science.gov (United States)

    Martins, Jorge Tiago; Martins, Rosa Maria

    2012-01-01

    This paper reports the implementation results of the Portuguese School Libraries Evaluation Model, more specifically the results of primary schools self-evaluation of their libraries' reading promotion and information literacy development activities. School libraries that rated their performance as either "Excellent" or "Poor"…

  15. A Two-Tiered Model for Analyzing Library Web Site Usage Statistics, Part 1: Web Server Logs.

    Science.gov (United States)

    Cohen, Laura B.

    2003-01-01

    Proposes a two-tiered model for analyzing web site usage statistics for academic libraries: one tier for library administrators that analyzes measures indicating library use, and a second tier for web site managers that analyzes measures aiding in server maintenance and site design. Discusses the technology of web site usage statistics, and…

  16. Portuguese School Libraries Evaluation Model: An Analysis of Primary Schools' Results for the "Reading and Literacy" Domain

    Science.gov (United States)

    Martins, Jorge Tiago; Martins, Rosa Maria

    2012-01-01

    This paper reports the implementation results of the Portuguese School Libraries Evaluation Model, more specifically the results of primary schools self-evaluation of their libraries' reading promotion and information literacy development activities. School libraries that rated their performance as either "Excellent" or "Poor"…

  17. 图书馆系统软件评价模型%Software Evaluation Model for Libraries

    Institute of Scientific and Technical Information of China (English)

    潘英; 丁晶

    2000-01-01

    The paper deals with the assessment of software products for libraries'computers before libraries purchase software products for documentary information management. Based on the Analytic Hierarchy Process, and according to the general evaluation criterions, an analytic hierarchy model is used to evaluate three computer software products for libraries.

  18. Portuguese School Libraries Evaluation Model: An Analysis of Primary Schools' Results for the "Reading and Literacy" Domain

    Science.gov (United States)

    Martins, Jorge Tiago; Martins, Rosa Maria

    2012-01-01

    This paper reports the implementation results of the Portuguese School Libraries Evaluation Model, more specifically the results of primary schools self-evaluation of their libraries' reading promotion and information literacy development activities. School libraries that rated their performance as either "Excellent" or "Poor" have been…

  19. 小型高校图书馆建立机构知识库探究%Explore the Institutional Repositories for Small Libraries of Colleges Establish

    Institute of Scientific and Technical Information of China (English)

    曹畋

    2015-01-01

    建立机构知识库是互联网环境下图书馆加强自身建设的有效方式。作为小型高校图书馆,建立机构知识库既要向领先的图书馆学习,也不可忽视自身的特点。着重探究了小型高校图书馆建立机构知识库的一些特点,希望能推动占据图书馆数量最多的小型高校图书馆的建设,指出小型高校图书馆建立机构知识库是时代的必然要求,小型高校图书馆是互联网环境下建立机构知识库的主力军,小型高校图书馆建立机构知识库有助于全国机构知识库的建设。%In Internet environment, establishing the institutional repository is an effective way for the library to strengthen the construction of its own. The small college libraries, in the course of constructing the institutional repository, not only should learn from the leading libraries but also cannot ignore its own characteristics. This paper emphatically explores some features of small college libraries in constructing the institutional repositories, hoping to promote the construction of small college libraries which occupy the largest proportion of libraries, and points out that constructing the institutional repositories in small college libraries is a necessary requirement of the era, the small college libraries are the main forces of constructing the institutional repositories in the Internet environment, and the construction of the institutional repositories in small college libraries is helpful to the construction of the national institutional repository.

  20. Library Use

    DEFF Research Database (Denmark)

    Konzack, Lars

    2012-01-01

    A seminar paper about a survey of role-playing games in public libraries combined with three cases and a presentation of a model.......A seminar paper about a survey of role-playing games in public libraries combined with three cases and a presentation of a model....

  1. ModFossa: A library for modeling ion channels using Python.

    Science.gov (United States)

    Ferneyhough, Gareth B; Thibealut, Corey M; Dascalu, Sergiu M; Harris, Frederick C

    2016-06-01

    The creation and simulation of ion channel models using continuous-time Markov processes is a powerful and well-used tool in the field of electrophysiology and ion channel research. While several software packages exist for the purpose of ion channel modeling, most are GUI based, and none are available as a Python library. In an attempt to provide an easy-to-use, yet powerful Markov model-based ion channel simulator, we have developed ModFossa, a Python library supporting easy model creation and stimulus definition, complete with a fast numerical solver, and attractive vector graphics plotting.

  2. A model library for dynamic transport and fate of micropollutants in integrated urban wastewater and stormwater systems

    DEFF Research Database (Denmark)

    Vezzaro, Luca; Benedetti, Lorenzo; Gevaert, Veerle

    2014-01-01

    for the elaboration of pollution control strategies (including both source control and treatment options) at the small spatial scale of urban areas. Existing and well-established water quality models for the different parts of the IUWS (e.g. ASM models) are extended by adding MP fate processes. These are modelled......The increasing efforts in reducing the emission of micropollutants (MP) into the natural aquatic environment require the development of modelling tools to support the decision making process. This article presents a library of dynamic modelling tools for estimating MP fluxes within Integrated Urban...... Wastewater and Stormwater system (IUWS – including drainage network, stormwater treatment units, wastewater treatment plants, sludge treatment, and the receiving water body). The models are developed by considering the high temporal variability of the processes taking place in the IUWS, providing a basis...

  3. Predicting Antitumor Activity of Peptides by Consensus of Regression Models Trained on a Small Data Sample

    Directory of Open Access Journals (Sweden)

    Ivanka Jerić

    2011-11-01

    Full Text Available Predicting antitumor activity of compounds using regression models trained on a small number of compounds with measured biological activity is an ill-posed inverse problem. Yet, it occurs very often within the academic community. To counteract, up to some extent, overfitting problems caused by a small training data, we propose to use consensus of six regression models for prediction of biological activity of virtual library of compounds. The QSAR descriptors of 22 compounds related to the opioid growth factor (OGF, Tyr-Gly-Gly-Phe-Met with known antitumor activity were used to train regression models: the feed-forward artificial neural network, the k-nearest neighbor, sparseness constrained linear regression, the linear and nonlinear (with polynomial and Gaussian kernel support vector machine. Regression models were applied on a virtual library of 429 compounds that resulted in six lists with candidate compounds ranked by predicted antitumor activity. The highly ranked candidate compounds were synthesized, characterized and tested for an antiproliferative activity. Some of prepared peptides showed more pronounced activity compared with the native OGF; however, they were less active than highly ranked compounds selected previously by the radial basis function support vector machine (RBF SVM regression model. The ill-posedness of the related inverse problem causes unstable behavior of trained regression models on test data. These results point to high complexity of prediction based on the regression models trained on a small data sample.

  4. Quality assessment and control of tissue specific RNA-seq libraries of Drosophila transgenic RNAi models.

    Science.gov (United States)

    Amaral, Andreia J; Brito, Francisco F; Chobanyan, Tamar; Yoshikawa, Seiko; Yokokura, Takakazu; Van Vactor, David; Gama-Carvalho, Margarida

    2014-01-01

    RNA-sequencing (RNA-seq) is rapidly emerging as the technology of choice for whole-transcriptome studies. However, RNA-seq is not a bias free technique. It requires large amounts of RNA and library preparation can introduce multiple artifacts, compounded by problems from later stages in the process. Nevertheless, RNA-seq is increasingly used in multiple studies, including the characterization of tissue-specific transcriptomes from invertebrate models of human disease. The generation of samples in this context is complex, involving the establishment of mutant strains and the delicate contamination prone process of dissecting the target tissue. Moreover, in order to achieve the required amount of RNA, multiple samples need to be pooled. Such datasets pose extra challenges due to the large variability that may occur between similar pools, mostly due to the presence of cells from surrounding tissues. Therefore, in addition to standard quality control of RNA-seq data, analytical procedures for control of "biological quality" are critical for successful comparison of gene expression profiles. In this study, the transcriptome of the central nervous system (CNS) of a Drosophila transgenic strain with neuronal-specific RNAi of an ubiquitous gene was profiled using RNA-seq. After observing the existence of an unusual variance in our dataset, we showed that the expression profile of a small panel of marker genes, including GAL4 under control of a tissue specific driver, can identify libraries with low levels of contamination from neighboring tissues, enabling the selection of a robust dataset for differential expression analysis. We further analyzed the potential of profiling a complex tissue to identify cell-type specific changes in response to target gene down-regulation. Finally, we showed that trimming 5' ends of reads decreases nucleotide frequency biases, increasing the coverage of protein coding genes with a potential positive impact in the incurrence of systematic

  5. Quality assessment and control of tissue specific RNA-seq libraries of Drosophila transgenic RNAi models

    Directory of Open Access Journals (Sweden)

    Andreia J Amaral

    2014-03-01

    Full Text Available RNA-sequencing (RNA-seq is rapidly emerging as the technology of choice for whole-transcriptome studies. However, RNA-seq is not a bias free technique. It requires large amounts of RNA and library preparation can introduce multiple artifacts, compounded by problems from later stages in the process. Nevertheless, RNA-seq is increasingly used in multiple studies, including the characterization of tissue-specific transcriptomes from invertebrate models of human disease. The generation of samples in this context is complex, involving the establishment of mutant strains and the delicate contamination prone process of dissecting the target tissue. Moreover, in order achieve the required amount of RNA, multiple samples need to be pooled. Such datasets pose extra challenges due to the large variability that may occur between similar pools, mostly due to the presence of cells from surrounding tissues. Therefore, in addition to standard quality control of RNA-seq data, analytical procedures for control of 'biological quality’ are critical for successful comparison of gene expression profiles. In this study, the transcriptome of the central nervous system of a Drosophila transgenic strain with neuronal-specific RNAi of an ubiquitous gene was profiled using RNA-seq. After observing the existence of an unusual variance in our dataset, we showed that the expression profile of a small panel of marker genes, including GAL4 under control of a tissue specific driver, can identify libraries with low levels of contamination from neighboring tissues, enabling the selection of a robust dataset for differential expression analysis. We further analyzed the potential of profiling a complex tissue to identify cell-type specific changes in response to target gene down-regulation. Finally, we showed that trimming 5’ ends of reads decreases nucleotide frequency biases, increasing the coverage of protein coding genes and decreasing the occurrence of systematic technical

  6. Online Library of Scientific Models, A New Way to Teach, Learn, and Share Learning Experience

    Directory of Open Access Journals (Sweden)

    Hatem H. Elrefaei

    2008-05-01

    Full Text Available While scientific models are usually communicated in paper format, the need to reprogram every model by every user results in a huge loss of efforts, time and money, hence lengthening the educational and research developing cycle and loosing the learning experience and expertise gained by every user. We demonstrate a new portal www.imodelit.com that hosts a library of scientific models for electrical engineers in the form of java applets. They are all conformal, informative, with strong input and output filing system. The software design allows a fast developing cycle and it represents a strong infrastructure that can be shared by researchers to develop their own applets to be posted on the library. We aim for a community based library of scientific models that enhances the e-learning process for engineering students.

  7. Combinatorial library discovery of small molecule inhibitors of lung cancer proliferation and parathyroid hormone-related protein expression.

    Science.gov (United States)

    Hastings, Randolph H; Burton, Douglas W; Nefzi, Adel; Montgrain, Philippe R; Quintana, Rick; Deftos, Leonard J

    2010-11-15

    PTHrP (parathyroid hormone-related protein) is abnormally expressed in a substantial majority of lung cancers, especially non-small cell lung cancers, and plays a key role in tumor progression. Thus, this oncoprotein could be a target for treating patients with lung cancer. This study screened combinatorial libraries of heterocyclic amines for inhibitory effects on PTHrP expression and cell proliferation. Two libraries of over 780,000 bis-cyclic thiourea and guanidine compounds each were tested in BEN lung carcinoma cells. The number of PTHrP inhibitors and the magnitude of the reduction in PTHrP were greater for thioureas. Selected lead thiourea compounds decreased cell PTHrP protein content in dose-dependent fashion, reduced relative abundance of PTHrP mRNA, decreased transcripts derived from the PTHrP P3 promoter and reduced activity of a full length PTHrP promoter luciferase construct. Similar effects on PTHrP mRNA were observed in A549 and H441 lung adenocarcinoma cells and in H727 lung carcinoid cells. However, the compounds only inhibited PTHrP protein levels in BEN cells and H727 cells. The compounds reduced the rate of cell proliferation in BEN cells and H727 cells, but not in lines that showed no inhibition of PTHrP protein. These results suggest that cyclic thiourea compounds inhibit PTHrP expression mediated by the P3 promoter, which is widely used in the majority of PTHrP-expressing cells, and that they may inhibit growth of lung cancer cells through the same mechanism. Further work will be necessary to investigate their mechanism for effects on growth of PTHrP-positive tumors in vivo.

  8. Advanced Small Modular Reactor Economics Model Development

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, Thomas J [ORNL

    2014-10-01

    The US Department of Energy Office of Nuclear Energy’s Advanced Small Modular Reactor (SMR) research and development activities focus on four key areas: Developing assessment methods for evaluating advanced SMR technologies and characteristics; and Developing and testing of materials, fuels and fabrication techniques; and Resolving key regulatory issues identified by US Nuclear Regulatory Commission and industry; and Developing advanced instrumentation and controls and human-machine interfaces. This report focuses on development of assessment methods to evaluate advanced SMR technologies and characteristics. Specifically, this report describes the expansion and application of the economic modeling effort at Oak Ridge National Laboratory. Analysis of the current modeling methods shows that one of the primary concerns for the modeling effort is the handling of uncertainty in cost estimates. Monte Carlo–based methods are commonly used to handle uncertainty, especially when implemented by a stand-alone script within a program such as Python or MATLAB. However, a script-based model requires each potential user to have access to a compiler and an executable capable of handling the script. Making the model accessible to multiple independent analysts is best accomplished by implementing the model in a common computing tool such as Microsoft Excel. Excel is readily available and accessible to most system analysts, but it is not designed for straightforward implementation of a Monte Carlo–based method. Using a Monte Carlo algorithm requires in-spreadsheet scripting and statistical analyses or the use of add-ons such as Crystal Ball. An alternative method uses propagation of error calculations in the existing Excel-based system to estimate system cost uncertainty. This method has the advantage of using Microsoft Excel as is, but it requires the use of simplifying assumptions. These assumptions do not necessarily bring into question the analytical results. In fact, the

  9. Performance of the libraries in Isfahan University of Medical Sciences based on the EFQM model.

    Science.gov (United States)

    Karimi, Saeid; Atashpour, Bahareh; Papi, Ahmad; Nouri, Rasul; Hasanzade, Akbar

    2014-01-01

    Performance measurement is inevitable for university libraries. Hence, planning and establishing a constant and up-to-date measurement system is required for the libraries, especially the university libraries. The primary studies and analyses reveal that the EFQM Excellence Model has been efficient, and the administrative reform program has focused on the implementation of this model. Therefore, on the basis of these facts as well as the need for a measurement system, the researchers measured the performance of libraries in schools and hospitals supported by Isfahan University of Medical Sciences, using the EFQM Organizational Excellence Model. This descriptive research study was carried out by a cross-sectional survey method in 2011. This research study included librarians and library directors of Isfahan University of Medical Sciences (70 people). The validity of the instrument was measured by the specialists in the field of Management and Library Science. To measure the reliability of the questionnaire, the Cronbach's alpha coefficient value was measured (0.93). The t-test, ANOVA, and Spearman's rank correlation coefficient were used for measurements. The data were analyzed by SPSS. Data analysis revealed that the mean score of the performance measurement for the libraries under study and between nine dimensions the highest score was 65.3% for leadership dimension and the lowest scores were 55.1% for people and 55.1% for society results. In general, using the ninth EFQM model the average level of all dimensions, which is in good agreement with normal values, was assessed. However, compared to other results, the criterion people and society results were poor. It is Recommended by forming the expert committee on criterion people and society results by individuals concerned with the various conferences and training courses to improve the aspects.

  10. Service Concepts and Work Characteristics of American Public Libraries -- The Comment of the Best Small Library in America 2012%美国公共图书馆的服务理念与工作特色——“2012美国最佳小图书馆”评析

    Institute of Scientific and Technical Information of China (English)

    吴德岗

    2012-01-01

    The Best Small Library in America 2012 has been awarded to the Independence Public Library, KS. The two finalists are: Decatur Public Library, TX and Dover Town Library, MA. These libraries not only focus on the community service, pay attention to the publicity, improve their images hardly, but also reform their management and service model along with time change. A variety of activities have been held by these libraries, and particularly they provide special services for children readers. Besides, they cOllaborate with many agencies and enterprises. These provide enlightenments for libraries in China.%在"2012美国最佳小图书馆"的评选中,堪萨斯独立城公共图书馆获得冠军,德克萨斯迪凯特公共图书馆、马萨诸塞多弗镇图书馆也入围最后的决赛。这些图书馆以社区服务为核心,非常重视自身宣传,努力提高图书馆形象,为适应时代需求改革管理与服务模式,大力开展丰富多样的活动,特别重视为少年儿童读者提供特色服务,注重与各机构及企业的合作,对我国图书馆服务有很好的启示作用。

  11. Longitudinal dispersion modeling in small streams

    Science.gov (United States)

    Pekarova, Pavla; Pekar, Jan; Miklanek, Pavol

    2014-05-01

    The environmental problems caused by the increasing of pollutant loads discharged into natural water bodies are very complex. For that reason the cognition of transport mechanism and mixing characteristics in natural streams is very important. The mathematical and numerical models have become very useful tools for solving the water management problems. The mathematical simulations based on numerical models of pollution mixing in streams can be used (for example) for prediction of spreading of accidental contaminant waves in rivers. The paper deals with the estimation of the longitudinal dispersion coefficients and with the numerical simulation of transport and transformation of accidental pollution in the small natural streams. There are different ways of solving problems of pollution spreading in open channels, in natural rivers. One of them is the hydrodynamic approach, which endeavours to understand and quantify the spreading phenomenon in a stream. The hydrodynamic models are based on advection-diffusion equation and the majority of them are one-dimensional models. Their disadvantage is inability to simulate the spread of pollution until complete dispersion of pollutant across the stream section is finished. Two-dimensional mixing models do not suffer from these limitations. On the other hand, the one-dimensional models are simpler than two-dimensional ones, they need not so much input data and they are often swifter. Three-dimensional models under conditions of natural streams are applicable with difficulties (or inapplicable) for their complexity and demands on accuracy and amount of input data. As there was mentioned above the two-dimensional models can be used also until complete dispersion of pollutant across the stream section is not finished, so we decided to apply the two-dimensional model SIRENIE. Experimental microbasin Rybarik is the part of the experimental Mostenik brook basin of IH SAS Bratislava. It was established as a Field Hydrological

  12. An Exploratory Study to Develop an Alternative Model of Public Library Management Using the Institute of Museum and Library Services' Public Library Statistics

    Science.gov (United States)

    Kim, Giyeong; Yu, So Young

    2011-01-01

    In this explorative study, we first investigate current use of public library statistics in public library management to identify a governing framework and then carefully suggest an alternative framework with income as a goal for sustainability. The meaning of income in terms of management is also discussed. Within this framework, we conduct a…

  13. Evaluation of a Digital Library by Means of Quality Function Deployment (QFD) and the Kano Model

    Science.gov (United States)

    Garibay, Cecilia; Gutierrez, Humberto; Figueroa, Arturo

    2010-01-01

    This paper proposes utilizing a combination of the Quality Function Deployment (QFD)-Kano model as a useful tool to evaluate service quality. The digital library of the University of Guadalajara (Mexico) is presented as a case study. Data to feed the QFD-Kano model was gathered by an online questionnaire that was made available to users on the…

  14. Software Technology for Adaptable, Reliable System (STARS) Program. Reuse Library Process Model.

    Science.gov (United States)

    The Process Model described in this document is part of the Guidebook requirements for the STARS Reuse Library described in Subtask IS40.3 of the S...Increment Task Proposal for STARS. The objective of a Process Model is to formally characterize the various processes that take place in the context of

  15. From activity to learning: using cultural historical activity theory to model school library programmes and practices

    Directory of Open Access Journals (Sweden)

    E.M. Meyers

    2007-01-01

    Full Text Available Introduction. changes in educational policy and practice demand that we examine school library programmes from a new perspective. As a model that takes a developmental view of minds in context, Cultural Historical Activity Theory is particularly well suited to the study of school libraries and the learning that occurs therein. This paper focuses on the activity theoretic concepts of 'contradictions' and 'expansive learning' as they relate to the development of best practices. Method. Developmental Work Research was applied as a guiding methodology in an intervention study of six high school libraries in Washington State, USA. Library activity is illustrated from multiple perspectives using a triangulated, qualitative approach. Analysis. contradictions and tensions in the general school library activity system are identified, and an intervention was designed to facilitiate the development of expansive instruments. A case example illustrates a second level of analysis and specific points of intervention. Results. analysis reveals that the tensions and contradictions provide opportunities for expansive learning on the part of the teacher-Librarians. The research team can use practitioners' zones of proximal development to guide the alignment of library programme goals and practices. Conclusion. : some limitations and future promise of the framework and its application are discussed. The proposed activity theory toolkit suggest a new way of exploring the practices of teacher-librarians, incorporating research evidence, professional expertise, and reflective decision making.

  16. Strategic Model for Implementing Knowledge Management in Libraries and Information Services

    Directory of Open Access Journals (Sweden)

    Octavia-Luciana Porumbeanu

    2009-01-01

    Full Text Available In most fields of activity one can notice the trend towards knowledge-based organizations and towards flexible organizations that encourage innovation and change. In this context, knowledge management has become a fundamental process for all types of organizations in society. Libraries and information services are integral part of the knowledge system, these organizations being one of the forms that contribute to knowledge development. This article presents a strategic model for implementing knowledge management in libraries and information services, created on the basis of the results from theoretical researches and practical applications of this process in organizations from different countries and different fields of activity and keeping in mind the specific characteristics of libraries and information services. The model is based on five fundamental elements from which one should begin implementation of a knowledge management function in the organizations engaged in information transfer.

  17. Mining non-model genomic libraries for microsatellites: BAC versus EST libraries and the generation of allelic richness

    Directory of Open Access Journals (Sweden)

    Shaw Kerry L

    2010-07-01

    Full Text Available Abstract Background Simple sequence repeats (SSRs are tandemly repeated sequence motifs common in genomic nucleotide sequence that often harbor significant variation in repeat number. Frequently used as molecular markers, SSRs are increasingly identified via in silico approaches. Two common classes of genomic resources that can be mined are bacterial artificial chromosome (BAC libraries and expressed sequence tag (EST libraries. Results 288 SSR loci were screened in the rapidly radiating Hawaiian swordtail cricket genus Laupala. SSRs were more densely distributed and contained longer repeat structures in BAC library-derived sequence than in EST library-derived sequence, although neither repeat density nor length was exceptionally elevated despite the relatively large genome size of Laupala. A non-random distribution favoring AT-rich SSRs was observed. Allelic diversity of SSRs was positively correlated with repeat length and was generally higher in AT-rich repeat motifs. Conclusion The first large-scale survey of Orthopteran SSR allelic diversity is presented. Selection contributes more strongly to the size and density distributions of SSR loci derived from EST library sequence than from BAC library sequence, although all SSRs likely are subject to similar physical and structural constraints, such as slippage of DNA replication machinery, that may generate increased allelic diversity in AT-rich sequence motifs. Although in silico approaches work well for SSR locus identification in both EST and BAC libraries, BAC library sequence and AT-rich repeat motifs are generally superior SSR development resources for most applications.

  18. Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design.

    Science.gov (United States)

    Gilbreth, Ryan N; Truong, Khue; Madu, Ikenna; Koide, Akiko; Wojcik, John B; Li, Nan-Sheng; Piccirilli, Joseph A; Chen, Yuan; Koide, Shohei

    2011-05-10

    Discriminating closely related molecules remains a major challenge in the engineering of binding proteins and inhibitors. Here we report the development of highly selective inhibitors of small ubiquitin-related modifier (SUMO) family proteins. SUMOylation is involved in the regulation of diverse cellular processes. Functional differences between two major SUMO isoforms in humans, SUMO1 and SUMO2/3, are thought to arise from distinct interactions mediated by each isoform with other proteins containing SUMO-interacting motifs (SIMs). However, the roles of such isoform-specific interactions are largely uncharacterized due in part to the difficulty in generating high-affinity, isoform-specific inhibitors of SUMO/SIM interactions. We first determined the crystal structure of a "monobody," a designed binding protein based on the fibronectin type III scaffold, bound to the yeast homolog of SUMO. This structure illustrated a mechanism by which monobodies bind to the highly conserved SIM-binding site while discriminating individual SUMO isoforms. Based on this structure, we designed a SUMO-targeted library from which we obtained monobodies that bound to the SIM-binding site of human SUMO1 with K(d) values of approximately 100 nM but bound to SUMO2 400 times more weakly. The monobodies inhibited SUMO1/SIM interactions and, unexpectedly, also inhibited SUMO1 conjugation. These high-affinity and isoform-specific inhibitors will enhance mechanistic and cellular investigations of SUMO biology.

  19. Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design

    Energy Technology Data Exchange (ETDEWEB)

    Gilbreth, Ryan N.; Truong, Khue; Madu, Ikenna; Koide, Akiko; Wojcik, John B.; Li, Nan-Sheng; Piccirilli, Joseph A.; Chen, Yuan; Koide, Shohei (UC); (CHNMC)

    2011-07-25

    Discriminating closely related molecules remains a major challenge in the engineering of binding proteins and inhibitors. Here we report the development of highly selective inhibitors of small ubiquitin-related modifier (SUMO) family proteins. SUMOylation is involved in the regulation of diverse cellular processes. Functional differences between two major SUMO isoforms in humans, SUMO1 and SUMO2/3, are thought to arise from distinct interactions mediated by each isoform with other proteins containing SUMO-interacting motifs (SIMs). However, the roles of such isoform-specific interactions are largely uncharacterized due in part to the difficulty in generating high-affinity, isoform-specific inhibitors of SUMO/SIM interactions. We first determined the crystal structure of a 'monobody,' a designed binding protein based on the fibronectin type III scaffold, bound to the yeast homolog of SUMO. This structure illustrated a mechanism by which monobodies bind to the highly conserved SIM-binding site while discriminating individual SUMO isoforms. Based on this structure, we designed a SUMO-targeted library from which we obtained monobodies that bound to the SIM-binding site of human SUMO1 with K{sub d} values of approximately 100 nM but bound to SUMO2 400 times more weakly. The monobodies inhibited SUMO1/SIM interactions and, unexpectedly, also inhibited SUMO1 conjugation. These high-affinity and isoform-specific inhibitors will enhance mechanistic and cellular investigations of SUMO biology.

  20. 基于小数据的图书馆知识社区构建研究%Research on Library Knowledge Community Based on Small Data

    Institute of Scientific and Technical Information of China (English)

    牛勇

    2016-01-01

    Problems in the construction of library knowledge community are analyzed, and the concept and characteris-tics of small data are summarizes and compared with big data. Library knowledge community based on small data has four functions of the platform: user knowledge platform, group dynamic clustering platform, library knowledge accurate service platform, and library knowledge service innovation platform. Its construction includes four aspects: small data acquisition, knowledge community structure, privacy, and security.%针对目前图书馆知识社区建设中存在的问题,文章在分析小数据概念和特点并与大数据进行比较的基础上,提出了建设基于小数据的图书馆知识社区的思路,其内涵为将知识社区建设为用户自助知识平台、群组动态聚类平台、图书馆精准知识服务平台、图书馆知识服务创新平台,在此基础上文章分析了小数据采集、知识社区架构、隐私与安全等图书馆知识社区构建问题。

  1. Reutilizing Existing Library Space.

    Science.gov (United States)

    Davis, Marlys Cresap

    1987-01-01

    This discussion of the reutilization of existing library space reviews the decision process and considerations for implementation. Two case studies of small public libraries which reassigned space to better use are provided, including floor plans. (1 reference) (MES)

  2. Demand Driven Acquisition of E-Books in a Small Online Academic Library: Growing Pains and Assessing Gains

    Science.gov (United States)

    Longley, Dana H.

    2016-01-01

    How does a smaller, fully online academic library offer a wide and deep collection of academic level e-books to its distance learners in a sustainable and affordable way? The State University of New York (SUNY) Empire State College Online Library, with a staff of four, has used demand-driven e-book acquisitions since September 2013. Despite…

  3. Phage Library Screening for the Rapid Identification and In Vivo Testing of Candidate Genes for a DNA Vaccine against Mycoplasma mycoides subsp. mycoides Small Colony Biotype

    Science.gov (United States)

    March, John B.; Jepson, Catherine D.; Clark, Jason R.; Totsika, Makrina; Calcutt, Michael J.

    2006-01-01

    A new strategy for rapidly selecting and testing genetic vaccines has been developed, in which a whole genome library is cloned into a bacteriophage λ ZAP Express vector which contains both prokaryotic (Plac) and eukaryotic (PCMV) promoters upstream of the insertion site. The phage library is plated on Escherichia coli cells, immunoblotted, and probed with hyperimmune and/or convalescent-phase antiserum to rapidly identify vaccine candidates. These are then plaque purified and grown as liquid lysates, and whole bacteriophage particles are then used directly to immunize the host, following which PCMV-driven expression of the candidate vaccine gene occurs. In the example given here, a semirandom genome library of the bovine pathogen Mycoplasma mycoides subsp. mycoides small colony (SC) biotype was cloned into λ ZAP Express, and two strongly immunodominant clones, λ-A8 and λ-B1, were identified and subsequently tested for vaccine potential against M. mycoides subsp. mycoides SC biotype-induced mycoplasmemia. Sequencing and immunoblotting indicated that clone λ-A8 expressed an isopropyl-β-d-thiogalactopyranoside (IPTG)-inducible M. mycoides subsp. mycoides SC biotype protein with a 28-kDa apparent molecular mass, identified as a previously uncharacterized putative lipoprotein (MSC_0397). Clone λ-B1 contained several full-length genes from the M. mycoides subsp. mycoides SC biotype pyruvate dehydrogenase region, and two IPTG-independent polypeptides, of 29 kDa and 57 kDa, were identified on immunoblots. Following vaccination, significant anti-M. mycoides subsp. mycoides SC biotype responses were observed in mice vaccinated with clones λ-A8 and λ-B1. A significant stimulation index was observed following incubation of splenocytes from mice vaccinated with clone λ-A8 with whole live M. mycoides subsp. mycoides SC biotype cells, indicating cellular proliferation. After challenge, mice vaccinated with clone λ-A8 also exhibited a reduced level of mycoplasmemia

  4. Construction of an extended library of adult male 3D models: rationale and results

    Science.gov (United States)

    Broggio, D.; Beurrier, J.; Bremaud, M.; Desbrée, A.; Farah, J.; Huet, C.; Franck, D.

    2011-12-01

    In order to best cover the possible extent of heights and weights of male adults the construction of 25 whole body 3D models has been undertaken. Such a library is thought to be useful to specify the uncertainties and relevance of dosimetry calculations carried out with models representing individuals of average body heights and weights. Representative 3D models of Caucasian body types are selected in a commercial database according to their height and weight, and 3D models of the skeleton and internal organs are designed using another commercial dataset. A review of the literature enabled one to fix volume or mass target values for the skeleton, soft organs, skin and fat content of the selected individuals. The composition of the remainder tissue is fixed so that the weight of the voxel models equals the weight of the selected individuals. After mesh and NURBS modelling, volume adjustment of the selected body shapes and additional voxel-based work, 25 voxel models with 109 identified organs or tissue are obtained. Radiation transport calculations are carried out with some of the developed models to illustrate potential uses. The following points are discussed throughout this paper: justification of the fixed or obtained models' features regarding available and relevant literature data; workflow and strategy for major modelling steps; advantages and drawbacks of the obtained library as compared with other works. The construction hypotheses are explained and justified in detail since future calculation results obtained with this library will depend on them.

  5. Virtual Libraries: Interactive Support Software and an Application in Chaotic Models.

    Science.gov (United States)

    Katsirikou, Anthi; Skiadas, Christos; Apostolou, Apostolos; Rompogiannakis, Giannis

    This paper begins with a discussion of the characteristics and the singularity of chaotic systems, including dynamic systems theory, chaotic orbit, fractals, chaotic attractors, and characteristics of chaotic systems. The second section addresses the digital libraries (DL) concept and the appropriateness of chaotic models, including definition and…

  6. Making the Invisible Visible: Personas and Mental Models of Distance Education Library Users

    Science.gov (United States)

    Lewis, Cynthia; Contrino, Jacline

    2016-01-01

    Gaps between users' and designers' mental models of digital libraries often result in adverse user experiences. This article details an exploratory user research study at a large, predominantly online university serving non-traditional distance education students with the goal of understanding these gaps. Using qualitative data, librarians created…

  7. Partnerships in Medical Education: An Exploration of Library Service Models for Postgraduate Medicine at Macquarie University

    Science.gov (United States)

    Simons, Mary

    2008-01-01

    Macquarie University's new medical school, The Australian School of Advanced Medicine (ASAM), is developing a postgraduate program that incorporates a partnership with Macquarie University Library. The curriculum encompasses contemporary models of competency-based assessment, teamwork and lifelong learning that are integrated with research and…

  8. Getting Comfortable with Change: A New Budget Model for Libraries in Transition.

    Science.gov (United States)

    Campbell, Jerry D.

    1994-01-01

    Proposes a new transitional budget model to help make libraries adept at and comfortable with change during the transition to an increasingly electronic knowledge environment, emphasizing staff education and training, new service opportunities, user responsiveness, teamwork, fiscal empowerment, and more effective management systems. (Contains nine…

  9. mr: A C++ library for the matching and running of the Standard Model parameters

    Science.gov (United States)

    Kniehl, Bernd A.; Pikelner, Andrey F.; Veretin, Oleg L.

    2016-09-01

    We present the C++ program library mr that allows us to reliably calculate the values of the running parameters in the Standard Model at high energy scales. The initial conditions are obtained by relating the running parameters in the MS bar renormalization scheme to observables at lower energies with full two-loop precision. The evolution is then performed in accordance with the renormalization group equations with full three-loop precision. Pure QCD corrections to the matching and running are included through four loops. We also provide a Mathematica interface for this program library.

  10. mr: a C++ library for the matching and running of the Standard Model parameters

    CERN Document Server

    Kniehl, Bernd A; Veretin, Oleg L

    2016-01-01

    We present the C++ program library mr that allows us to reliably calculate the values of the running parameters in the Standard Model at high energy scales. The initial conditions are obtained by relating the running parameters in the $\\overline{\\mathrm{MS}}$ renormalization scheme to observables at lower energies with full two-loop precision. The evolution is then performed in accordance with the renormalization group equations with full three-loop precision. Pure QCD corrections to the matching and running are included through four loops. We also provide a Mathematica interface for this program library.

  11. Generating Collaborative Systems for Digital Libraries: a Model-Driven Approach

    Directory of Open Access Journals (Sweden)

    Alessio Malizia

    2010-12-01

    Full Text Available The design and development of a digital library involves different stakeholders, such as: information architects, librarians, and domain experts, who need to agree on a common language to describe, discuss, and negotiate the services the library has to offer. To this end, high-level, language-neutral models have to be devised. Metamodeling techniques favor the definition of domainspecific visual languages through which stakeholders can share their views and directly manipulate representations of the domain entities. This paper describes CRADLE (Cooperative-Relational Approach to Digital Library Environments, a metamodel-based framework and visual language for the definition of notions and services related to the development of digital libraries. A collection of tools allows the automatic generation of several services, defined with the CRADLE visual language, and of the graphical user interfaces providing access to them for the final user. The effectiveness of the approach is illustrated by presenting digital libraries generated with CRADLE, while the CRADLE environment has been evaluated by using the cognitive dimensions framework.

  12. The Arizona Universities Library Consortium patron-driven e-book model

    Directory of Open Access Journals (Sweden)

    Jeanne Richardson

    2013-03-01

    Full Text Available Building on Arizona State University's patron-driven acquisitions (PDA initiative in 2009, the Arizona Universities Library Consortium, in partnership with the Ingram Content Group, created a cooperative patron-driven model to acquire electronic books (e-books. The model provides the opportunity for faculty and students at the universities governed by the Arizona Board of Regents (ABOR to access a core of e-books made accessible through resource discovery services and online catalogs. These books are available for significantly less than a single ABOR university would expend for the same materials. The patron-driven model described is one of many evolving models in digital scholarship, and, although the Arizona Universities Library Consortium reports a successful experience, patron-driven models pose questions to stakeholders in the academic publishing industry.

  13. Modeling proteins using a super-secondary structure library and NMR chemical shift information.

    Science.gov (United States)

    Menon, Vilas; Vallat, Brinda K; Dybas, Joseph M; Fiser, Andras

    2013-06-04

    A remaining challenge in protein modeling is to predict structures for sequences with no sequence similarity to any experimentally solved structure. Based on earlier observations, the library of protein backbone supersecondary structure motifs (Smotifs) saturated about a decade ago. Therefore, it should be possible to build any structure from a combination of existing Smotifs with the help of limited experimental data that are sufficient to relate the backbone conformations of Smotifs between target proteins and known structures. Here, we present a hybrid modeling algorithm that relies on an exhaustive Smotif library and on nuclear magnetic resonance chemical shift patterns without any input of primary sequence information. In a test of 102 proteins, the algorithm delivered 90 homology-model-quality models, among them 24 high-quality ones, and a topologically correct solution for almost all cases. The current approach opens a venue to address the modeling of larger protein structures for which chemical shifts are available.

  14. A Critical Information Literacy Model: Library Leadership within the Curriculum

    Science.gov (United States)

    Swanson, Troy

    2011-01-01

    It is a time for a new model for teaching students to find, evaluate, and use information by drawing on critical pedagogy theory in the education literature. This critical information literacy model views the information world as a dynamic place where authors create knowledge for many reasons; it seeks to understand students as information users,…

  15. Geographic location as an access model to library collections – a pilot project of European Digital Library

    Directory of Open Access Journals (Sweden)

    Dalibor Radovan

    2007-01-01

    Full Text Available In the frames of the European eContentplus project European Digital Library (EDL a pilot GIS application was integrated in The European Library (TEL portal. The application was realized in the cooperation between the National and University Library of Slovenia and the Geodetic Institute of Slovenia. The pilot GIS application represents the beginning of the development of digital geolibrary where a map is the starting point leading to different geodifferentiated resources. At the same time, it also represents an upgrade of the static presentation of different kinds of digitised materials in the library, as well as an attempt of interdisciplinary presentation with additional educational value. The goal, content, methodology and the results of the pilot GIS application are presented in the article.

  16. Fundamental principles of data assimilation underlying the Verdandi library: applications to biophysical model personalization within euHeart

    OpenAIRE

    Chapelle, Dominique; Fragu, Marc; Mallet, Vivien; Moireau, Philippe

    2013-01-01

    International audience; We present the fundamental principles of data assimilation underlying the Verdandi library, and how they are articulated with the modular architecture of the library. This translates -- in particular -- into the definition of standardized interfaces through which the data assimilation library interoperates with the model simulation software and the so-called observation manager. We also survey various examples of data assimilation applied to the personalization of biop...

  17. Lessons Learned Model Checking an Industrial Communications Library

    Science.gov (United States)

    2005-09-01

    Lecture Notes in Computer Science [LNCS], volume 2057). Toronto, Canada, May 19-20, 2001. Berlin...Model Checking,” 128-147. Integrated Formal Methods: The 4th International Conference (IFM 2004) ( Lecture Notes in Computer Science [LNCS], volume...on Computer Aided Verification (CAV 1990). ( Lecture Notes in Computer Science [LNCS], volume 531). New Brunswick, NJ, June 18-21, 1990.

  18. Client value models provide a framework for rational library planning (or, phrasing the answer in the form of a question).

    Science.gov (United States)

    Van Moorsel, Guillaume

    2005-01-01

    Libraries often do not know how clients value their product/ service offerings. Yet at a time when the mounting costs for library support are increasingly difficult to justify to the parent institution, the library's ability to gauge the value of its offerings to clients has never been more critical. Client Value Models (CVMs) establish a common definition of value elements-or a "value vocabulary"-for libraries and their clients, thereby providing a basis upon which to make rational planning decisions regarding product/service acquisition and development. The CVM concept is borrowed from business and industry, but its application has a natural fit in libraries. This article offers a theoretical consideration and practical illustration of CVM application in libraries.

  19. Scanning electron microscope measurement of width and shape of 10 nm patterned lines using a JMONSEL-modeled library

    Energy Technology Data Exchange (ETDEWEB)

    Villarrubia, J.S., E-mail: john.villarrubia@nist.gov [Semiconductor and Dimensional Metrology Division, National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States); Vladár, A.E.; Ming, B. [Semiconductor and Dimensional Metrology Division, National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States); Kline, R.J.; Sunday, D.F. [Materials Science and Engineering Division, National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States); Chawla, J.S.; List, S. [Intel Corporation, RA3-252, 5200 NE Elam Young Pkwy, Hillsboro, OR 97124 (United States)

    2015-07-15

    The width and shape of 10 nm to 12 nm wide lithographically patterned SiO{sub 2} lines were measured in the scanning electron microscope by fitting the measured intensity vs. position to a physics-based model in which the lines' widths and shapes are parameters. The approximately 32 nm pitch sample was patterned at Intel using a state-of-the-art pitch quartering process. Their narrow widths and asymmetrical shapes are representative of near-future generation transistor gates. These pose a challenge: the narrowness because electrons landing near one edge may scatter out of the other, so that the intensity profile at each edge becomes width-dependent, and the asymmetry because the shape requires more parameters to describe and measure. Modeling was performed by JMONSEL (Java Monte Carlo Simulation of Secondary Electrons), which produces a predicted yield vs. position for a given sample shape and composition. The simulator produces a library of predicted profiles for varying sample geometry. Shape parameter values are adjusted until interpolation of the library with those values best matches the measured image. Profiles thereby determined agreed with those determined by transmission electron microscopy and critical dimension small-angle x-ray scattering to better than 1 nm.

  20. Novel small RNA expression libraries uncover hsa-miR-30b and hsa-miR-30c as important factors in anoikis resistance.

    Science.gov (United States)

    Moreno-Mateos, Miguel A; Barragán, Verónica; Torres, Belén; Rodríguez-Mateo, Cristina; Méndez-Vidal, Cristina; Berezikov, Eugene; Mudduluru, Giridhar; Allgayer, Heike; Pintor-Toro, José A

    2013-12-01

    MicroRNAs (miRNAs) have been widely studied in order to elucidate their biological functions. MicroRNA microarrays or miRNA overexpression libraries generated by synthesis and cloning of individual miRNAs have been used to study their different roles. In this work, we have developed a novel methodology to express mature miRNAs and other small RNAs from a double convergent RNA polymerase III promoter. We show that the generated miRNAs function similarly to those processed from primary transcripts or pri-miRNAs. This system allowed us to produce a lentiviral library expressing the whole population of small RNAs present in a metastatic cell line. A functional screening using this library led to the identification of hsa-miR-30b and hsa-miR-30c as negative regulators of cell death induced by loss of attachment (anoikis). Importantly, we demonstrated that the acquisition of anoikis resistance via these miRNAs is achieved through down-regulation of caspase 3 expression. Moreover, overexpression of these miRNAs resulted in a decrease of other types of caspase 3-dependent cell death and enhanced the survival of MCF10A acinar cells in morphogenesis assays, suggesting a putative role as oncomirs. In summary, this novel methodology provides a powerful and effective way for identifying novel small RNAs involved in a particular biological process.

  1. PeptideBuilder: A simple Python library to generate model peptides

    Directory of Open Access Journals (Sweden)

    Matthew Z. Tien

    2013-05-01

    Full Text Available We present a simple Python library to construct models of polypeptides from scratch. The intended use case is the generation of peptide models with pre-specified backbone angles. For example, using our library, one can generate a model of a set of amino acids in a specific conformation using just a few lines of python code. We do not provide any tools for energy minimization or rotamer packing, since powerful tools are available for these purposes. Instead, we provide a simple Python interface that enables one to add residues to a peptide chain in any desired conformation. Bond angles and bond lengths can be manipulated if so desired, and reasonable values are used by default.

  2. A Modelica-based Model Library for Building Energy and Control Systems

    Energy Technology Data Exchange (ETDEWEB)

    Wetter, Michael

    2009-04-07

    This paper describes an open-source library with component models for building energy and control systems that is based on Modelica, an equation-based objectoriented language that is well positioned to become the standard for modeling of dynamic systems in various industrial sectors. The library is currently developed to support computational science and engineering for innovative building energy and control systems. Early applications will include controls design and analysis, rapid prototyping to support innovation of new building systems and the use of models during operation for controls, fault detection and diagnostics. This paper discusses the motivation for selecting an equation-based object-oriented language. It presents the architecture of the library and explains how base models can be used to rapidly implement new models. To demonstrate the capability of analyzing novel energy and control systems, the paper closes with an example where we compare the dynamic performance of a conventional hydronic heating system with thermostatic radiator valves to an innovative heating system. In the new system, instead of a centralized circulation pump, each of the 18 radiators has a pump whose speed is controlled using a room temperature feedback loop, and the temperature of the boiler is controlled based on the speed of the radiator pump. All flows are computed by solving for the pressure distribution in the piping network, and the controls include continuous and discrete time controls.

  3. Kinetic identification of protein ligands in a 51,200 small-molecule library using microarrays and a label-free ellipsometric scanner

    Science.gov (United States)

    Landry, James P.; Proudian, Andrew P.; Malovichko, Galina; Zhu, Xiangdong

    2013-02-01

    Drug discovery begins by identifying protein-small molecule binding pairs. Afterwards, binding kinetics and biofunctional assays are performed, to reduce candidates for further development. High-throughput screening, typically employing fluorescence, is widely used to find protein ligands in small-molecule libraries, but is rarely used for binding kinetics measurement because: (1) attaching fluorophores to proteins can alter kinetics and (2) most label-free technologies for kinetics measurement are inherently low-throughput and consume expensive sensing surfaces. We addressed this need with polarization-modulated ellipsometric scanning microscopes, called oblique-incidence reflectivity difference (OI-RD). Label-free ligand screening and kinetics measurement are performed simultaneously on small-molecule microarrays printed on relatively inexpensive isocyanate-functionalized glass slides. As a microarray is reacted, an OI-RD microscope tracks the change in surface-bound macromolecule density in real-time at every spot. We report progress applying OI-RD to screen purified proteins and virus particles against a 51,200-compound library from the National Cancer Institute. Four microarrays, each containing 12,800 library compounds, are installed in four flow cells in an automated OI-RD microscope. The slides are reacted serially, each giving 12,800 binding curves with ~30 sec time resolution. The entire library is kinetically screened against a single probe in ~14 hours and multiple probes can be reacted sequentially under automation. Real-time binding detection identifies both high-affinity and low-affinity (transient binding) interactions; fluorescence endpoint images miss the latter. OI-RD and microarrays together is a powerful high-throughput tool for early stage drug discovery and development. The platform also has great potential for downstream steps such as in vitro inhibition assays.

  4. ON SOME APPROACHES TO ECONOMICMATHEMATICAL MODELING OF SMALL BUSINESS

    Directory of Open Access Journals (Sweden)

    Orlov A. I.

    2015-04-01

    Full Text Available Small business is an important part of modern Russian economy. We give a wide panorama developed by us of possible approaches to the construction of economic-mathematical models that may be useful to describe the dynamics of small businesses, as well as management. As for the description of certain problems of small business can use a variety of types of economic-mathematical and econometric models, we found it useful to consider a fairly wide range of such models, which resulted in quite a short description of the specific models. In this description of the models brought to such a level that an experienced professional in the field of economic-mathematical modeling could, if necessary, to develop their own specific model to the stage of design formulas and numerical results. Particular attention is paid to the use of statistical methods of non-numeric data, the most pressing at the moment. Are considered the problems of economic-mathematical modeling in solving problems of small business marketing. We have accumulated some experience in application of the methodology of economic-mathematical modeling in solving practical problems in small business marketing, in particular in the field of consumer goods and industrial purposes, educational services, as well as in the analysis and modeling of inflation, taxation and others. In marketing models of decision making theory we apply rankings and ratings. Is considered the problem of comparing averages. We present some models of the life cycle of small businesses - flow model projects, model of capture niches, and model of niche selection. We discuss the development of research on economic-mathematical modeling of small businesses

  5. Development of the acquisition model of online information resources at Faculty of Medicine Library, Khon Kaen University.

    Science.gov (United States)

    Thanapaisal, Soodjai; Thanapaisal, Chaiwit

    2013-09-01

    Faculty of Medicine Library, Khon Kaen University started to acquire online information resources since 2001 with the subscriptions to 2 databases. Nowadays it has 29 items of subscriptions and the expenses on online information resources reach to 17 million baht, more than 70 percent of the information resources budget, serving the academic purposes of the Faculty of Medicine. The problems of online information resources acquisition fall into 4 categories, and lead to 4 aspects conforming the model of the acquisition, comparing or benchmarking with the 4 selected medical school libraries in Bangkok, Chiang Mai, and Songkhla, and discussion with some other Thai and foreign libraries. The acquisition model of online information resources is developed from those problems and proposed for Faculty of Medicine Library, Khon Kaen University as well as for any medical libraries which prefer.

  6. GPCR-GRAPA-LIB--a refined library of hidden Markov Models for annotating GPCRs.

    Science.gov (United States)

    Shigeta, Ron; Cline, Melissa; Liu, Guoying; Siani-Rose, Michael A

    2003-03-22

    GPCR-GRAPA-LIB is a library of HMMs describing G protein coupled receptor families. These families are initially defined by class of receptor ligand, with divergent families divided into subfamilies using phylogenic analysis and knowledge of GPCR function. Protein sequences are applied to the models with the GRAPA curve-based selection criteria. RefSeq sequences for Homo sapiens, Drosophila melanogaster, and Caenorhabditis elegans have been annotated using this approach.

  7. Nonlinear model reduction for dynamical systems using sparse sensor locations from learned libraries

    Science.gov (United States)

    Sargsyan, Syuzanna; Brunton, Steven L.; Kutz, J. Nathan

    2015-09-01

    We demonstrate the synthesis of sparse sampling and dimensionality reduction to characterize and model nonlinear dynamical systems over a range of bifurcation parameters. First, we construct modal libraries using the classical proper orthogonal decomposition in order to expose the dominant low-rank coherent structures. Here, libraries of the nonlinear terms are also constructed in order to take advantage of the discrete empirical interpolation method and projection that allows for the approximation of nonlinear terms from a sparse number of grid points. The selected grid points are shown to be effective sensing and measurement locations for characterizing the underlying dynamics, stability, and bifurcations of nonlinear dynamical systems. The use of empirical interpolation points and sparse representation facilitates a family of local reduced-order models for each physical regime, rather than a higher-order global model, which has the benefit of physical interpretability of energy transfer between coherent structures. The method advocated also allows for orders-of-magnitude improvement in computational speed and memory requirements. To illustrate the method, the discrete interpolation points and nonlinear modal libraries are used for sparse representation in order to classify and reconstruct the dynamic bifurcation regimes in the complex Ginzburg-Landau equation. It is also shown that point measurements of the nonlinearity are more effective than linear measurements when sensor noise is present.

  8. [Empowering the family-center health model: the toy library as a health promotion platform].

    Science.gov (United States)

    Huang, Yu-Chu; Tsai, Yen-Chih

    2011-02-01

    Facing the lowest birth rates in its history, Taiwan is increasingly recognizing the centrality of children's healthcare needs to effective family care. The World Health Organization's goal of health for all emphasizes health promotion. However, little research attention has been given to how families actively promote personal health in everyday life. This article considers 'family-centric' healthcare, with a particular emphasis on children's health and well-being and the mother health promotion model. Authors employ a 'toy library' as the health promotion platform to build community interaction and empower the health enhancement process. Results suggested the following: 1. The fixed-point type toy library may be an effective tool in a health promotion strategy; 2. A model may be developed for rural institution agencies; 3. Cooperation may be facilitated using a medical service vehicle; 4. The love bag program can serve extended purposes. The authors found that the empowerment and growth of tribal mothers is a key element to facilitate the successful development of their children. Based on findings, the implementation of a toy library as the platform to build community-based health promotion model is suggested.

  9. Comparison Between Overtopping Discharge in Small and Large Scale Models

    DEFF Research Database (Denmark)

    Helgason, Einar; Burcharth, Hans F.

    2006-01-01

    small and large scale model tests show no clear evidence of scale effects for overtopping above a threshold value. In the large scale model no overtopping was measured for waveheights below Hs = 0.5m as the water sunk into the voids between the stones on the crest. For low overtopping scale effects...... are presented as the small-scale model underpredicts the overtopping discharge....

  10. Small-scale models of multiring basins

    Science.gov (United States)

    Allemand, Pascal; Thomas, Pierre

    1999-07-01

    Small-scale sand-silicone simulations of multiring impact structures have been undertaken in order to understand the effects of the rheology of the lithosphere on the variability of natural multiring structures. For low sand-silicone thickness ratio (1:3), brittle strain is accommodated by spiral strike-slip faults. For higher sand-silicone ratios (1:1 or 2:1), an inner concentric ring affected by strike-slip faults is relayed by an external ring affected by concentric normal faults. The diameter of the inner ring decreases with the increase of the sand-silicone thickness ratio. It is suggested that the flexure of the brittle layer due to the silicone flow is responsible for the brittle strain field which is enhanced by the channel flow of the lower crust. The characteristic geometry of the intersection of conjugated strike-slip faults can be observed around large multiring basins on silicate crust such as Orientale on the Moon and on icy crust, such as Valhalla on Callisto and Gilgamesh on Ganymede. The strain field around these large craters is discussed in terms of mechanical properties of the lithospheres. On the Moon, large craters without relaxation faults, such as Imbrium are located on thin crust regions. The crust was too thin to have a ductile lower layer at the time of impact. Gilgamesh on Ganymede is surrounded mainly by strike-slip faults. Asgard on Callisto has the same diameter as Gilgamesh but is surrounded by concentric normal faults. The brittle-ductile thickness ratio is thus higher on Callisto than on Ganymede.

  11. Preliminary assessment of Geant4 HP models and cross section libraries by reactor criticality benchmark calculations

    DEFF Research Database (Denmark)

    Cai, Xiao-Xiao; Llamas-Jansa, Isabel; Mullet, Steven

    2013-01-01

    to reactor modelling. Before version 9.5, Geant4 HP thermal scattering model (i.e. the S(α; β) model ) supports only three bounded isotopes, namely, H in water and polyethylene, and C in graphite. Newly supported materials include D in heavy water, O and Be in beryllium oxide, H and Zr in zirconium hydride......, U and O in uranium dioxide, Al metal, Be metal, and Fe metal. The native HP cross section library G4NDL does not include data for elements with atomic number larger than 92. Therefore, transuranic elements, which have impacts for a realistic reactor, can not be simulated by the combination of the HP...

  12. Development of 3D Female Breast Model Library for Bra Design

    Institute of Scientific and Technical Information of China (English)

    WANG Jian-ping; ZHANG Wei-yuan

    2006-01-01

    As the maturity of female costume concept as well as the social consuming activities, a new and higher requirement is imposed on female underwear design. Human body model is the basic of many applications on 3D garment CAD. This paper delivered a novel approach for modeling a human body which could be driven by related body dimensions to form a female breast model library based on the free form deformation technologies. The 3D female breast shape reserve has a strong potential of being used for bra design,bra fitting, virtual try-on and exhibition to meet "made-tomeasure" demand of the booming bra market in the world.

  13. Integration of Library Services in the System of Digital Libraries

    Science.gov (United States)

    Bezdushnyj, A. N.; Kalenov, N. E.; Kouriv, P. M.; Serebryakov, V. A.

    The article is devoted to the functional extension of the Integrated System of Information Resources of RAS (ISIR RAS - RFBR 99-07-90139 project). This extension (Library Subsystem) provides integration of library services in ISIR RAS electronic libraries system. Library Subsystem implements standard library services such as information about free and ordered copies of editions, creation of the library orders for edition etc. The Library Subsystem is an integrated solution; it's based on ISIR data model and technologies.

  14. High-performance small-scale solvers for linear Model Predictive Control

    DEFF Research Database (Denmark)

    Frison, Gianluca; Sørensen, Hans Henrik Brandenborg; Dammann, Bernd

    2014-01-01

    In Model Predictive Control (MPC), an optimization problem needs to be solved at each sampling time, and this has traditionally limited use of MPC to systems with slow dynamic. In recent years, there has been an increasing interest in the area of fast small-scale solvers for linear MPC......, with the two main research areas of explicit MPC and tailored on-line MPC. State-of-the-art solvers in this second class can outperform optimized linear-algebra libraries (BLAS) only for very small problems, and do not explicitly exploit the hardware capabilities, relying on compilers for that. This approach...... problems 2 to 8 times faster than the current state-of-the-art solver for this class of problems, and the high-performance is maintained for MPC problems with up to a few hundred states....

  15. Geometric Assortative Growth Model for Small-World Networks

    Directory of Open Access Journals (Sweden)

    Yilun Shang

    2014-01-01

    Full Text Available It has been shown that both humanly constructed and natural networks are often characterized by small-world phenomenon and assortative mixing. In this paper, we propose a geometrically growing model for small-world networks. The model displays both tunable small-world phenomenon and tunable assortativity. We obtain analytical solutions of relevant topological properties such as order, size, degree distribution, degree correlation, clustering, transitivity, and diameter. It is also worth noting that the model can be viewed as a generalization for an iterative construction of Farey graphs.

  16. Geometric assortative growth model for small-world networks.

    Science.gov (United States)

    Shang, Yilun

    2014-01-01

    It has been shown that both humanly constructed and natural networks are often characterized by small-world phenomenon and assortative mixing. In this paper, we propose a geometrically growing model for small-world networks. The model displays both tunable small-world phenomenon and tunable assortativity. We obtain analytical solutions of relevant topological properties such as order, size, degree distribution, degree correlation, clustering, transitivity, and diameter. It is also worth noting that the model can be viewed as a generalization for an iterative construction of Farey graphs.

  17. CREW Manual; A Unified System of Weeding, Inventory, and Collection-Building for Small and Medium-Sized Public Libraries.

    Science.gov (United States)

    Segal, Joseph P.

    Described is a practical approach to continuous reviews, evaluation and weeding (CREW) of library collections, its advantages, and the detailed procedure. Guides by Dewey classes are prepared including information as to age, maximum permissible time without usage, and the presence of various negative factors concerning the material. A bibliography…

  18.   Cell Penetrating Peptoids (CPPos: Synthesis of a Small Combinatorial Library by Using IRORI MiniKans

    Directory of Open Access Journals (Sweden)

    Dominik K. Kölmel

    2012-11-01

    Full Text Available Cell penetrating peptoids (CPPos are potent mimics of the corresponding cell penetrating peptides (CPPs. The synthesis of diverse oligomeric libraries that display a variety of backbone scaffolds and side-chain appendages are a very promising source of novel CPPos, which can be used to either target different cellular organelles or even different tissues and organs. In this study we established the submonomer-based solid phase synthesis of a “proof of principle” peptoid library in IRORI MiniKans to expand the amount for phenotypic high throughput screens of CPPos. The library consisting of tetrameric peptoids [oligo(N-alkylglycines] was established on Rink amide resin in a split and mix approach with hydrophilic and hydrophobic peptoid side chains. All CPPos of the presented library were labeled with rhodamine B to allow for the monitoring of cellular uptake by fluorescent confocal microscopy. Eventually, all the purified peptoids were subjected to live cell imaging to screen for CPPos with organelle specificity. While highly charged CPPos enter the cells by endocytosis with subsequent endosomal release, critical levels of lipophilicity allow other CPPos to specifically localize to mitochondria once a certain lipophilicity threshold is reached.

  19. Assessing the 24/5 Library: A Case Study in Data and Perspectives

    Science.gov (United States)

    Johnson, Ken; McCallister, Kelly

    2015-01-01

    The 24-hour/5-days-per-week (24/5) model at Belk Library & Information Commons has experienced multiple changes since first implemented in 2006. First the library started small, then expanded, then reduced, and finally expanded again. This article tells the story of a library's 24/5 evolution within the assessment cycle framework, describes…

  20. Methods for combinatorial and parallel library design.

    Science.gov (United States)

    Schnur, Dora M; Beno, Brett R; Tebben, Andrew J; Cavallaro, Cullen

    2011-01-01

    Diversity has historically played a critical role in design of combinatorial libraries, screening sets and corporate collections for lead discovery. Large library design dominated the field in the 1990s with methods ranging anywhere from purely arbitrary through property based reagent selection to product based approaches. In recent years, however, there has been a downward trend in library size. This was due to increased information about the desirable targets gleaned from the genomics revolution and to the ever growing availability of target protein structures from crystallography and homology modeling. Creation of libraries directed toward families of receptors such as GPCRs, kinases, nuclear hormone receptors, proteases, etc., replaced the generation of libraries based primarily on diversity while single target focused library design has remained an important objective. Concurrently, computing grids and cpu clusters have facilitated the development of structure based tools that screen hundreds of thousands of molecules. Smaller "smarter" combinatorial and focused parallel libraries replaced those early un-focused large libraries in the twenty-first century drug design paradigm. While diversity still plays a role in lead discovery, the focus of current library design methods has shifted to receptor based methods, scaffold hopping/bio-isostere searching, and a much needed emphasis on synthetic feasibility. Methods such as "privileged substructures based design" and pharmacophore based design still are important methods for parallel and small combinatorial library design. This chapter discusses some of the possible design methods and presents examples where they are available.

  1. A rotamer library to enable modeling and design of peptoid foldamers.

    Science.gov (United States)

    Renfrew, P Douglas; Craven, Timothy W; Butterfoss, Glenn L; Kirshenbaum, Kent; Bonneau, Richard

    2014-06-18

    Peptoids are a family of synthetic oligomers composed of N-substituted glycine units. Along with other "foldamer" systems, peptoid oligomer sequences can be predictably designed to form a variety of stable secondary structures. It is not yet evident if foldamer design can be extended to reliably create tertiary structure features that mimic more complex biomolecular folds and functions. Computational modeling and prediction of peptoid conformations will likely play a critical role in enabling complex biomimetic designs. We introduce a computational approach to provide accurate conformational and energetic parameters for peptoid side chains needed for successful modeling and design. We find that peptoids can be described by a "rotamer" treatment, similar to that established for proteins, in which the peptoid side chains display rotational isomerism to populate discrete regions of the conformational landscape. Because of the insufficient number of solved peptoid structures, we have calculated the relative energies of side-chain conformational states to provide a backbone-dependent (BBD) rotamer library for a set of 54 different peptoid side chains. We evaluated two rotamer library development methods that employ quantum mechanics (QM) and/or molecular mechanics (MM) energy calculations to identify side-chain rotamers. We show by comparison to experimental peptoid structures that both methods provide an accurate prediction of peptoid side chain placements in folded peptoid oligomers and at protein interfaces. We have incorporated our peptoid rotamer libraries into ROSETTA, a molecular design package previously validated in the context of protein design and structure prediction.

  2. Evaluation of usability of Spanish academic library web portals using a cognitive-emotional heuristic model

    Directory of Open Access Journals (Sweden)

    Daniel Muñoz-Egido

    2017-03-01

    Full Text Available In this paper a cognitive-emotional usability analysis model based on heuristics was used to analyze eighteen academic library web portals. Starting with a review of existing literature on the subject, a set of seventy-one heuristic criteria grouped into six aspects was designed, to which the metrics developed by SIRIUS were applied. The result of the evaluation reveals that the average usability of websites of university libraries analyzed stands at 72.30 over 100 with a standard deviation of 5.57. The aspects with the lowest scores were Attention and Long Term Memory and Learning, which were therefore approached less satisfactorily from the user’s point of view.

  3. A model library for simulation and benchmarking of integrated urban wastewater systems

    DEFF Research Database (Denmark)

    Saagi, Ramesh; Flores Alsina, Xavier; Kroll, J. S.

    2017-01-01

    ). The set of models describe the dynamics of flow rates and major pollutants (COD, TSS, N and P) within the catchment (CT), sewer network (SN), wastewater treatment plant (WWTP) and river water system (RW) for a hypothetical, though realistic, UWS. Evaluation criteria are developed to allow for direct......This paper presents a freely distributed, open-source toolbox to predict the behaviour of urban wastewater systems (UWS). The proposed library is used to develop a system-wide Benchmark Simulation Model (BSM-UWS) for evaluating (local/global) control strategies in urban wastewater systems (UWS...

  4. Computational Analysis and Predictive Cheminformatics Modeling of Small Molecule Inhibitors of Epigenetic Modifiers.

    Science.gov (United States)

    Jamal, Salma; Arora, Sonam; Scaria, Vinod

    2016-01-01

    The dynamic and differential regulation and expression of genes is majorly governed by the complex interactions of a subset of biomolecules in the cell operating at multiple levels starting from genome organisation to protein post-translational regulation. The regulatory layer contributed by the epigenetic layer has been one of the favourite areas of interest recently. This layer of regulation as we know today largely comprises of DNA modifications, histone modifications and noncoding RNA regulation and the interplay between each of these major components. Epigenetic regulation has been recently shown to be central to development of a number of disease processes. The availability of datasets of high-throughput screens for molecules for biological properties offer a new opportunity to develop computational methodologies which would enable in-silico screening of large molecular libraries. In the present study, we have used data from high throughput screens for the inhibitors of epigenetic modifiers. Computational predictive models were constructed based on the molecular descriptors. Machine learning algorithms for supervised training, Naive Bayes and Random Forest, were used to generate predictive models for the small molecule inhibitors of histone methyl-transferases and demethylases. Random forest, with the accuracy of 80%, was identified as the most accurate classifier. Further we complemented the study with substructure search approach filtering out the probable pharmacophores from the active molecules leading to drug molecules. We show that effective use of appropriate computational algorithms could be used to learn molecular and structural correlates of biological activities of small molecules. The computational models developed could be potentially used to screen and identify potential new biological activities of molecules from large molecular libraries and prioritise them for in-depth biological assays. To the best of our knowledge, this is the first and

  5. Characterizing and Modeling the Cost of Rework in a Library of Reusable Software Components

    Science.gov (United States)

    Basili, Victor R.; Condon, Steven E.; ElEmam, Khaled; Hendrick, Robert B.; Melo, Walcelio

    1997-01-01

    In this paper we characterize and model the cost of rework in a Component Factory (CF) organization. A CF is responsible for developing and packaging reusable software components. Data was collected on corrective maintenance activities for the Generalized Support Software reuse asset library located at the Flight Dynamics Division of NASA's GSFC. We then constructed a predictive model of the cost of rework using the C4.5 system for generating a logical classification model. The predictor variables for the model are measures of internal software product attributes. The model demonstrates good prediction accuracy, and can be used by managers to allocate resources for corrective maintenance activities. Furthermore, we used the model to generate proscriptive coding guidelines to improve programming, practices so that the cost of rework can be reduced in the future. The general approach we have used is applicable to other environments.

  6. The development and evaluation of a small ready-reference library collection for a rural practice: a case study.

    Science.gov (United States)

    Gotsick, P S; Friedman, R L; Stith, J B

    1979-04-01

    A demonstration core collection of twenty-four ready-reference sources and five journals was selected cooperatively by a solo practitioner in rural Menifee County, Kentucky, and the University of Kentucky Medical Center Library Field Librarian to fit the ready-reference and current awareness information needs of a primary care solo rural practice in eastern Kentucky. The collection selections were systematically assessed by the physician to determine their utility in filling the practitioner's information needs with regard to his particular situation in terms of medical experience and level of training, available library and educational resources, and the type of health problems seen in his practice. This assessment showed that the Rural Demonstration Library Collection completely filled the information needs of the physician 66% of the time materials were consulted and filled his immediate information needs either completely or partially 82% of the time the collection was searched. This demonstration has shown that, under a specific set of circumstances, a librarian and a solo rural practitioner can effectively work together in identifying health sciences materials which fit the information needs of a solo rural practitioner. It suggests that cooperation between a librarian and a physician is important in meeting information needs.

  7. A Study of compatibility between Iranian digital libraries user interface and the elements of Ellis model of information seeking behavior

    Directory of Open Access Journals (Sweden)

    Yaghoub Norouzi

    2014-10-01

    Full Text Available The goal of this study is to evaluate the compatibility between Iranian digital libraries user interface and the elements of Ellis model of information seeking behavior. This study was performed using evaluation method with a checklist. This list is based on six features of Ellis model, "Starting", "Chaining", "Browsing", "Differentiating", "Monitoring" and "Extracting" and included 110 sub-components that have been developed using Delphi method. The population of this study included 5 library softwares: Azarakhsh, Simorgh, Papyrus, Payam and Parvan. Results showed that the average of scores of user interface of softwares is as follows: in Starting 99.6, Chaining 117.2, Browsing 29.6, Differentiating 53. 2, Monitoring 22.4 and Extracting 39. Among the softwares of digital libraries, according to the total score for elements of Ellis model (1080, Azarakhsh with 549 points is in the first rank and had the highest support for elements of Ellis model. It also became clear that Chaining with 586 points (%55 had the highest support in softwares of digital libraries. Also the elements of Chaining, Starting and Differentiating earned sequently the highest rank in softwares of digital libraries. Finally, testing research hypotheses with %95 confidence showed that among softwares of digital libraries there is no significant difference regarding the rate of support of elements of information seeking behavior of Ellis model.

  8. Holonic Business Process Modeling in Small to Medium Sized Enterprises

    Directory of Open Access Journals (Sweden)

    Nur Budi Mulyono

    2012-01-01

    Full Text Available Holonic modeling analysis which is the application of system thinking in design, manage, and improvement, is used in a novel context for business process modeling. An approach and techniques of holon and holarchies is presented specifically for small and medium sized enterprise process modeling development. The fitness of the approach is compared with well known reductionist or task breakdown approach. The strength and weaknesses of the holonic modeling is discussed with illustrating case example in term of its suitability for an Indonesia’s small and medium sized industry. The novel ideas in this paper have great impact on the way analyst should perceive business process. Future research is applying the approach in supply chain context.Key words: Business process, holonic modeling, operations management, small to medium sized enterprise

  9. The Motivational Knowledge Management Model: proposal to apply it in the library sector

    Directory of Open Access Journals (Sweden)

    Daniel López-Fernández

    2016-12-01

    Full Text Available In professional environments, attention paid to aspects such as supervisory styles, interpersonal relationships and workers eagerness can have a positive impact on employee motivation and, consequently, on their performance and well-being. To achieve this, knowledge management models such as those presented here can be applied. This model generates diagnoses of motivation and recommendations for improvement, both systematically and scientifically. Consequently, it is especially useful for managers and human resource departments. The proposed model can be adapted to different kinds of professional groups, including those in library and documentation services. The suitability, reliability and usefulness of the proposed model have been empirically checked through case studies with 92 students and 166 professionals. The positive results allow us to conclude that the model is effective and useful for assessing and improving motivation.

  10. Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor.

    Science.gov (United States)

    Wu, Zining; Graybill, Todd L; Zeng, Xin; Platchek, Michael; Zhang, Jean; Bodmer, Vera Q; Wisnoski, David D; Deng, Jianghe; Coppo, Frank T; Yao, Gang; Tamburino, Alex; Scavello, Genaro; Franklin, G Joseph; Mataruse, Sibongile; Bedard, Katie L; Ding, Yun; Chai, Jing; Summerfield, Jennifer; Centrella, Paolo A; Messer, Jeffrey A; Pope, Andrew J; Israel, David I

    2015-12-14

    DNA-encoded small-molecule library technology has recently emerged as a new paradigm for identifying ligands against drug targets. To date, this technology has been used with soluble protein targets that are produced and used in a purified state. Here, we describe a cell-based method for identifying small-molecule ligands from DNA-encoded libraries against integral membrane protein targets. We use this method to identify novel, potent, and specific inhibitors of NK3, a member of the tachykinin family of G-protein coupled receptors (GPCRs). The method is simple and broadly applicable to other GPCRs and integral membrane proteins. We have extended the application of DNA-encoded library technology to membrane-associated targets and demonstrate the feasibility of selecting DNA-tagged, small-molecule ligands from complex combinatorial libraries against targets in a heterogeneous milieu, such as the surface of a cell.

  11. Holonic Business Process Modeling in Small to Medium Sized Enterprises

    OpenAIRE

    Nur Budi Mulyono; Tezar Yuliansyah Saputra; Nur Arief Rahmatsyah

    2012-01-01

    Holonic modeling analysis which is the application of system thinking in design, manage, and improvement, is used in a novel context for business process modeling. An approach and techniques of holon and holarchies is presented specifically for small and medium sized enterprise process modeling development. The fitness of the approach is compared with well known reductionist or task breakdown approach. The strength and weaknesses of the holonic modeling is discussed with illustrating case exa...

  12. Deterministic multidimensional growth model for small-world networks

    CERN Document Server

    Peng, Aoyuan

    2011-01-01

    We proposed a deterministic multidimensional growth model for small-world networks. The model can characterize the distinguishing properties of many real-life networks with geometric space structure. Our results show the model possesses small-world effect: larger clustering coefficient and smaller characteristic path length. We also obtain some accurate results for its properties including degree distribution, clustering coefficient and network diameter and discuss them. It is also worth noting that we get an accurate analytical expression for calculating the characteristic path length. We verify numerically and experimentally these main features.

  13. Small Sample Properties of Bayesian Multivariate Autoregressive Time Series Models

    Science.gov (United States)

    Price, Larry R.

    2012-01-01

    The aim of this study was to compare the small sample (N = 1, 3, 5, 10, 15) performance of a Bayesian multivariate vector autoregressive (BVAR-SEM) time series model relative to frequentist power and parameter estimation bias. A multivariate autoregressive model was developed based on correlated autoregressive time series vectors of varying…

  14. Structural analysis and molecular modeling of two antitrichosanthin IgE clones from phage antibody library

    Institute of Scientific and Technical Information of China (English)

    LIZONGDONG; YURENYUAN; 等

    1997-01-01

    Recently we constructed a murine IgE phage surface display library and screened out two IgE (Fab) clones with specific binding activity to Trichosanthin (TCS).In this work,the Vε and Vκ genes of the two clones were sequenced and their putative germline gene usages were studied.On the basis of the known 3D structure of Trichosanthin and antibody,molecular modeling was carried out to study the antigen-antibody interaction.The possible antigenic determinant sites on the surface of TCS recognized by both the clones were analyzed,and the reaction forces between TCS and two Fab fragments were also analyzed respectively.

  15. Determining Criteria to Measuring of the E-readiness Level of Academic Libraries Based of IUP Model

    OpenAIRE

    Yaghoub Norouzi; Ismaiel Jafarpour

    2012-01-01

    Preparation of a community or organization to take part and benefit from development of information and communication technology defined as e-readiness. The aim of this study was determining criteria to measuring of the e-readiness level of academic libraries. In this regard, the published literature in the field of e-readiness reviewed, and eventually the IUP (Information Utilization Potential) model cited as a reference. Then, using the Delphi method and library and information science ...

  16. Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).

    Science.gov (United States)

    Deng, Hongfeng; O'Keefe, Heather; Davie, Christopher P; Lind, Kenneth E; Acharya, Raksha A; Franklin, G Joseph; Larkin, Jonathan; Matico, Rosalie; Neeb, Michael; Thompson, Monique M; Lohr, Thomas; Gross, Jeffrey W; Centrella, Paolo A; O'Donovan, Gary K; Bedard, Katie L Sargent; van Vloten, Kurt; Mataruse, Sibongile; Skinner, Steven R; Belyanskaya, Svetlana L; Carpenter, Tiffany Y; Shearer, Todd W; Clark, Matthew A; Cuozzo, John W; Arico-Muendel, Christopher C; Morgan, Barry A

    2012-08-23

    The metalloprotease ADAMTS-5 is considered a potential target for the treatment of osteoarthritis. To identify selective inhibitors of ADAMTS-5, we employed encoded library technology (ELT), which enables affinity selection of small molecule binders from complex mixtures by DNA tagging. Selection of ADAMTS-5 against a four-billion member ELT library led to a novel inhibitor scaffold not containing a classical zinc-binding functionality. One exemplar, (R)-N-((1-(4-(but-3-en-1-ylamino)-6-(((2-(thiophen-2-yl)thiazol-4-yl)methyl)amino)-1,3,5-triazin-2-yl)pyrrolidin-2-yl)methyl)-4-propylbenzenesulfonamide (8), inhibited ADAMTS-5 with IC(50) = 30 nM, showing >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1, ADAMTS-13, MMP-13, and TACE. Extensive SAR studies showed that potency and physicochemical properties of the scaffold could be further improved. Furthermore, in a human osteoarthritis cartilage explant study, compounds 8 and 15f inhibited aggrecanase-mediated (374)ARGS neoepitope release from aggrecan and glycosaminoglycan in response to IL-1β/OSM stimulation. This study provides the first small molecule evidence for the critical role of ADAMTS-5 in human cartilage degradation.

  17. Collisions of Small Nuclei in the Thermal Model

    CERN Document Server

    Cleymans, J; Oeschler, H.; Redlich, K.; Sharma, N.

    2016-01-01

    An analysis is presented of the expectations of the thermal model for particle production in collisions of small nuclei. The maxima observed in particle ratios of strange particles to pions as a function of beam energy in heavy ion collisions, are reduced when considering smaller nuclei. Of particular interest is the $\\Lambda/\\pi^+$ ratio shows the strongest maximum which survives even in collisions of small nuclei.

  18. Empirical spatial econometric modelling of small scale neighbourhood

    Science.gov (United States)

    Gerkman, Linda

    2012-07-01

    The aim of the paper is to model small scale neighbourhood in a house price model by implementing the newest methodology in spatial econometrics. A common problem when modelling house prices is that in practice it is seldom possible to obtain all the desired variables. Especially variables capturing the small scale neighbourhood conditions are hard to find. If there are important explanatory variables missing from the model, the omitted variables are spatially autocorrelated and they are correlated with the explanatory variables included in the model, it can be shown that a spatial Durbin model is motivated. In the empirical application on new house price data from Helsinki in Finland, we find the motivation for a spatial Durbin model, we estimate the model and interpret the estimates for the summary measures of impacts. By the analysis we show that the model structure makes it possible to model and find small scale neighbourhood effects, when we know that they exist, but we are lacking proper variables to measure them.

  19. Algebraic approach to small-world network models

    Science.gov (United States)

    Rudolph-Lilith, Michelle; Muller, Lyle E.

    2014-01-01

    We introduce an analytic model for directed Watts-Strogatz small-world graphs and deduce an algebraic expression of its defining adjacency matrix. The latter is then used to calculate the small-world digraph's asymmetry index and clustering coefficient in an analytically exact fashion, valid nonasymptotically for all graph sizes. The proposed approach is general and can be applied to all algebraically well-defined graph-theoretical measures, thus allowing for an analytical investigation of finite-size small-world graphs.

  20. Designing Collaborative Developmental Standards by Refactoring of the Earth Science Models, Libraries, Workflows and Frameworks.

    Science.gov (United States)

    Mirvis, E.; Iredell, M.

    2015-12-01

    The operational (OPS) NOAA National Centers for Environmental Prediction (NCEP) suite, traditionally, consist of a large set of multi- scale HPC models, workflows, scripts, tools and utilities, which are very much depending on the variety of the additional components. Namely, this suite utilizes a unique collection of the in-house developed 20+ shared libraries (NCEPLIBS), certain versions of the 3-rd party libraries (like netcdf, HDF, ESMF, jasper, xml etc.), HPC workflow tool within dedicated (sometimes even vendors' customized) HPC system homogeneous environment. This domain and site specific, accompanied with NCEP's product- driven large scale real-time data operations complicates NCEP collaborative development tremendously by reducing chances to replicate this OPS environment anywhere else. The NOAA/NCEP's Environmental Modeling Center (EMC) missions to develop and improve numerical weather, climate, hydrological and ocean prediction through the partnership with the research community. Realizing said difficulties, lately, EMC has been taken an innovative approach to improve flexibility of the HPC environment by building the elements and a foundation for NCEP OPS functionally equivalent environment (FEE), which can be used to ease the external interface constructs as well. Aiming to reduce turnaround time of the community code enhancements via Research-to-Operations (R2O) cycle, EMC developed and deployed several project sub-set standards that already paved the road to NCEP OPS implementation standards. In this topic we will discuss the EMC FEE for O2R requirements and approaches in collaborative standardization, including NCEPLIBS FEE and models code version control paired with the models' derived customized HPC modules and FEE footprints. We will share NCEP/EMC experience and potential in the refactoring of EMC development processes, legacy codes and in securing model source code quality standards by using combination of the Eclipse IDE, integrated with the

  1. Organisational models in agriculture with special reference to small farmers

    Directory of Open Access Journals (Sweden)

    Zakić Nebojša

    2014-01-01

    Full Text Available Agricultural value chains can be understood as the systems of people, organizations and activities needed to create process and deliver agricultural products from producers to consumers. Over time and due to huge changes that have happened in the surroundings, agricultural value chains have become very integrated and complex. Small farmers can prosper by joining in modern higher-level agricultural value chains, but there are numerous obstacles, as well. The work presents the typology of organizational models for agricultural production that consists of the models organised by producers, agribusiness companies (processors, retail chains, and intermediaries, facilitators (governments, non-governmental organisations and completely integrated models, established by some big companies. None of these models provides ideal solutions from the perspective of small producers. However, they say that the institutions, such as cooperatives and small farmers' organisations, present important mechanisms for including small producers in modern value chains and realizing the cooperation with agribusiness companies and other important players. This is also important for decision-makers and governmental bodies that should create a suitable environment and provide support so that small farmers and their organisations can integrate in modern value chains in a successful way.

  2. Small intestinal model for electrically propelled capsule endoscopy

    Directory of Open Access Journals (Sweden)

    Woo Sang Hyo

    2011-12-01

    Full Text Available Abstract The aim of this research is to propose a small intestine model for electrically propelled capsule endoscopy. The electrical stimulus can cause contraction of the small intestine and propel the capsule along the lumen. The proposed model considered the drag and friction from the small intestine using a thin walled model and Stokes' drag equation. Further, contraction force from the small intestine was modeled by using regression analysis. From the proposed model, the acceleration and velocity of various exterior shapes of capsule were calculated, and two exterior shapes of capsules were proposed based on the internal volume of the capsules. The proposed capsules were fabricated and animal experiments were conducted. One of the proposed capsules showed an average (SD velocity in forward direction of 2.91 ± 0.99 mm/s and 2.23 ± 0.78 mm/s in the backward direction, which was 5.2 times faster than that obtained in previous research. The proposed model can predict locomotion of the capsule based on various exterior shapes of the capsule.

  3. Update on Small Modular Reactors Dynamics System Modeling Tool -- Molten Salt Cooled Architecture

    Energy Technology Data Exchange (ETDEWEB)

    Hale, Richard Edward [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Cetiner, Sacit M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Fugate, David L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Qualls, A L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Borum, Robert C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Chaleff, Ethan S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Rogerson, Doug W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Batteh, John J. [Modelon Corporation (Sweden); Tiller, Michael M. [Xogeny Corporation, Canton, MI (United States)

    2014-08-01

    The Small Modular Reactor (SMR) Dynamic System Modeling Tool project is in the third year of development. The project is designed to support collaborative modeling and study of various advanced SMR (non-light water cooled) concepts, including the use of multiple coupled reactors at a single site. The objective of the project is to provide a common simulation environment and baseline modeling resources to facilitate rapid development of dynamic advanced reactor SMR models, ensure consistency among research products within the Instrumentation, Controls, and Human-Machine Interface (ICHMI) technical area, and leverage cross-cutting capabilities while minimizing duplication of effort. The combined simulation environment and suite of models are identified as the Modular Dynamic SIMulation (MoDSIM) tool. The critical elements of this effort include (1) defining a standardized, common simulation environment that can be applied throughout the program, (2) developing a library of baseline component modules that can be assembled into full plant models using existing geometry and thermal-hydraulic data, (3) defining modeling conventions for interconnecting component models, and (4) establishing user interfaces and support tools to facilitate simulation development (i.e., configuration and parameterization), execution, and results display and capture.

  4. Model-guided ligation strategy for optimal assembly of DNA libraries.

    Science.gov (United States)

    Ng, Daphne T W; Sarkar, Casim A

    2012-10-01

    DNA ligation is essential to many molecular biology manipulations, but this reaction is often carried out by following generic guidelines or by trial and error. Maximizing the desired ligation product is especially important in DNA library construction for directed evolution experiments since library diversity is directly affected by ligation efficiency. Here, we suggest that display vectors that rely on Type IIP restriction sites for cloning should be redesigned to utilize Type IIS restriction sites instead because ligation yield is significantly improved: we observed up to 15- and 2.6-fold increases in desired products for circular and linear ligation reactions, respectively. To guide ligation optimization more rationally, we developed an easily parameterized thermodynamic model that predicts product distributions based on input DNA concentrations and free energies of the ligation events. We applied this model to study ligation reactions using a ribosome display vector redesigned with Type IIS restriction sites (pRDV2). We computationally predicted and experimentally validated the relative abundance of various products in three-piece linear ligations as well as the extent of transformation from vector-insert circular ligations. Based on our results, we provide general insights into ligation and we outline guidelines for optimizing this reaction for both in vivo and in vitro display methodologies.

  5. Small populations corrections for selection-mutation models

    CERN Document Server

    Jabin, Pierre-Emmanuel

    2012-01-01

    We consider integro-differential models describing the evolution of a population structured by a quantitative trait. Individuals interact competitively, creating a strong selection pressure on the population. On the other hand, mutations are assumed to be small. Following the formalism of Diekmann, Jabin, Mischler, and Perthame, this creates concentration phenomena, typically consisting in a sum of Dirac masses slowly evolving in time. We propose a modification to those classical models that takes the effect of small populations into accounts and corrects some abnormal behaviours.

  6. SU-E-J-93: Development of Pre-Contoured Human Model Library in DICOM-RT Format for the Epidemiological Study of the Radiotherapy Patients

    Energy Technology Data Exchange (ETDEWEB)

    Pyakuryal, A; Lee, C [National Cancer Institute, Rockville, MD (United States); Lee, C [University of Michigan, Ann Arbor, MI (United States); Pelletier, C [East Carolina University, Greenville, NC (United States); Jung, J [East Carolina Univ, Greenville, NC (United States)

    2015-06-15

    Purpose: Prior to 3D conformal radiation therapy planning, patient anatomy information was mostly limited to 2D beams-eye-view from the conventional simulator. To analyze the outcomes of such treatments for radiation late effects, 3D computational human models are often used in commercial treatment planning systems (TPSs). However, several underlying difficulties such as time-consuming manual delineation procedures of a large number of structures in the model have always limited its applications. Primary objective of this work was to develop a human model library for the epidemiological study by converting 3D-surface model organs to DICOM-RT format (DICOM-RT structure) using an in-house built software. We converted the ICRP reference human models to DICOM-RT models, which can be readily adopted for various dose calculations. Methods: MATLAB based code were utilized to convert the contour drawings extracted in text-format from the 3D graphic-tool, Rhinoceros into DICOM-RT structure format for 50 different organs of each model using a 16GB dual-core processor. The conversion periods were measured for each DICOM-RT models, and the reconstructed structure volumes were validated against the original 3D-surface models in the TPS. Ten reference hybrid whole-body models (8-pediatric and 2-adults) were automatically processed to create DICOM-RT computational human model library. Results: Mean contour conversion period was found to be 580 (N=2) and 394.5 (N=8) seconds for 50 organs in the adult and pediatric models respectively. A good agreement for large organs (NRMSD <1.0%) and small organs (NRMSD <7.7%) was also observed between the original volumes and corresponding DICOM-RT structure volumes of the organs. Conclusion: The ICRP reference human models were converted into DICOM-RT format to support the epidemiological study using a large cohort of conventional radiotherapy patients. Due to its DICOM-compatibility, the library may be implemented to many other different

  7. Microscopic nuclear models for astrophysics: The Brussels BRUSLIB nuclear library and beyond

    Science.gov (United States)

    Arnould, M.; Goriely, S.

    2006-10-01

    Astrophysics is in need of a broad variety of nuclear data. This concerns static ground state properties, characteristics of excited nuclei, spontaneous decay properties, or interactions of nuclei with (mainly) nucleons, α-particles or photons. A strong theoretical activity complementing laboratory efforts is also mandatory. A large variety of highly ‘exotic’ laboratory-unreachable nuclei are indeed involved in the astrophysics modelling. Even when laboratory-studied nuclei are considered, theory has very often to be called for. Mastering the huge volume of nuclear information and making it available in an accurate and usable form for incorporation into astrophysics models is clearly of pivotal importance. The recognition of this necessity has been the driving motivation for the construction of the Brussels library (BRUSLIB) of computed data of astrophysics relevance. It provides an extended information in tabular form on masses, nuclear level densities and partition functions, fission barriers, and thermonuclear reaction rates. In addition of the unprecedented broadness of its scope, BRUSLIB has the unique and most important feature of relying to the largest possible extent on global and coherent microscopic nuclear models. The models of this sort that we have developed to predict the basic properties of the nuclei and of their interactions are briefly reviewed. The content of the BRUSLIB library that relies on these models is described, as well as a user-friendly nuclear network generator (NETGEN) complementing BRUSLIB. Finally, an application of BRUSLIB and NETGEN to the p-process nucleosynthesis during He detonation in sub-Chandrasekhar CO white dwarfs is proposed.

  8. Microscopic nuclear models for astrophysics: The Brussels BRUSLIB nuclear library and beyond

    Energy Technology Data Exchange (ETDEWEB)

    Arnould, M. [Institut d Astronomie et d Astrophysique, CP 226, Universite Libre de Bruxelles, 1050 Brussels (Belgium)]. E-mail: marnould@astro.ulb.ac.be; Goriely, S. [Institut d Astronomie et d Astrophysique, CP 226, Universite Libre de Bruxelles, 1050 Brussels (Belgium)

    2006-10-17

    Astrophysics is in need of a broad variety of nuclear data. This concerns static ground state properties, characteristics of excited nuclei, spontaneous decay properties, or interactions of nuclei with (mainly) nucleons, {alpha}-particles or photons. A strong theoretical activity complementing laboratory efforts is also mandatory. A large variety of highly 'exotic' laboratory-unreachable nuclei are indeed involved in the astrophysics modelling. Even when laboratory-studied nuclei are considered, theory has very often to be called for. Mastering the huge volume of nuclear information and making it available in an accurate and usable form for incorporation into astrophysics models is clearly of pivotal importance. The recognition of this necessity has been the driving motivation for the construction of the Brussels library (BRUSLIB) of computed data of astrophysics relevance. It provides an extended information in tabular form on masses, nuclear level densities and partition functions, fission barriers, and thermonuclear reaction rates. In addition of the unprecedented broadness of its scope, BRUSLIB has the unique and most important feature of relying to the largest possible extent on global and coherent microscopic nuclear models. The models of this sort that we have developed to predict the basic properties of the nuclei and of their interactions are briefly reviewed. The content of the BRUSLIB library that relies on these models is described, as well as a user-friendly nuclear network generator (NETGEN) complementing BRUSLIB. Finally, an application of BRUSLIB and NETGEN to the p-process nucleosynthesis during He detonation in sub-Chandrasekhar CO white dwarfs is proposed.

  9. Finite Elements Modeling in Diagnostics of Small Closed Pneumothorax.

    Science.gov (United States)

    Lorkowski, J; Mrzygłód, M; Grzegorowska, O

    2015-01-01

    Posttraumatic pneumothorax still remains to be a serious clinical problem and requires a comprehensive diagnostic and monitoring during treatment. The aim of this paper is to present a computer method of modeling of small closed pneumothorax. Radiological images of 34 patients of both sexes with small closed pneumothorax were taken into consideration. The control group consisted of X-rays of 22 patients treated because of tension pneumothorax. In every single case the model was correlated with the clinical manifestations. The procedure of computational rapid analysis (CRA) for in silico analysis of surgical intervention was introduced. It included implementation of computerize tomography images and their automatic conversion into 3D finite elements model (FEM). In order to segmentize the 3D model, an intelligent procedure of domain recognition was used. In the final step, a computer simulation project of fluid-structure interaction was built, using the ANSYS\\Workbench environment of multi-physics analysis. The FEM model and computer simulation project were employed in the analysis in order to optimize surgical intervention. The model worked out well and was compatible with the clinical manifestations of pneumothorax. We conclude that the created FEM model is a promising tool for facilitation of diagnostic procedures and prognosis of treatment in the case of small closed pneumothorax.

  10. PROPOSAL OF A MODEL MANAGEMENT TO SMALL DESIGN COMPANIES

    Directory of Open Access Journals (Sweden)

    Otávio José de OLIVEIRA

    2008-11-01

    Full Text Available The main purpose of this paper is the proposition of a management model specifically developed for small building design firms, aligned with their needs and particularities. The field research was conducted with a qualitative approach through the analysis of four case studies in small building design firms acting mainly in São Paulo City. The data collection was accomplished through semi-structured interviews, direct observation and analysis of documents. The proposed model includes guidance to the management of the core processes and activities of small building design firms, such as: organizational structure; strategic planning; planning and control of design process; costs management; sales management; information systems; human resources management; services added to the design; and performance evaluation. Key-words: design firms; design process; building construction.

  11. Design and Modelling of Small Scale Low Temperature Power Cycles

    DEFF Research Database (Denmark)

    Wronski, Jorrit

    impact on the work output of the expander.The final part of this report deals with the performance of plate heat exchangers. Several plate heat exchanger correlations were reviewed focussing on their applicability to ORC systems. A framework for dynamic heat exchanger modelling was developed......he work presented in this report contributes to the state of the art within design and modelling of small scale low temperature power cycles. The study is divided into three main parts: (i) fluid property evaluation, (ii) expansion device investigations and (iii) heat exchanger performance...... times and below 10−7 away from the phase boundaries.Regarding expansion devices for small scale organic Rankine cycle (ORC) systems,this work focussed on reciprocating machines. A prototype of a reciprocating expander with a swept volume of 736 cm3 was tested and modelled. he model was written in object...

  12. Waste Reduction Model (WARM) Resources for Small Businesses and Organizations

    Science.gov (United States)

    This page provides a brief overview of how EPA’s Waste Reduction Model (WARM) can be used by small businesses and organizations. The page includes a brief summary of uses of WARM for the audience and links to other resources.

  13. On the small-time behavior of stochastic logistic models

    Directory of Open Access Journals (Sweden)

    Dung Tien Nguyen

    2017-09-01

    Full Text Available In this paper we investigate the small-time behaviors of the solution to  a stochastic logistic model. The obtained results allow us to estimate the number of individuals in the population and can be used to study stochastic prey-predator systems.

  14. Small-Scale Helicopter Automatic Autorotation: Modeling, Guidance, and Control

    NARCIS (Netherlands)

    Taamallah, S.

    2015-01-01

    Our research objective consists in developing a, model-based, automatic safety recovery system, for a small-scale helicopter Unmanned Aerial Vehicle (UAV) in autorotation, i.e. an engine OFF flight condition, that safely flies and lands the helicopter to a pre-specified ground location. In pursuit o

  15. The Academic Knowledge Management Model of Small Schools in Thailand

    Science.gov (United States)

    Tumtuma, Chamnan; Chantarasombat, Chalard; Yeamsang, Theerawat

    2015-01-01

    The Academic Knowledge Management Model of Small Schools in Thailand was created by research and development. The quantitative and qualitative data were collected via the following steps: a participatory workshop meeting, the formation of a team according to knowledge base, field study, brainstorming, group discussion, activities carried out…

  16. Small data global existence for a fluid-structure model

    Science.gov (United States)

    Ignatova, Mihaela; Kukavica, Igor; Lasiecka, Irena; Tuffaha, Amjad

    2017-02-01

    We address the system of partial differential equations modeling motion of an elastic body inside an incompressible fluid. The fluid is modeled by the incompressible Navier-Stokes equations while the structure is represented by the damped wave equation with interior damping. The additional boundary stabilization γ, considered in our previous paper, is no longer necessary. We prove the global existence and exponential decay of solutions for small initial data in a suitable Sobolev space.

  17. How to Use Benchmark and Cross-section Studies to Improve Data Libraries and Models

    Science.gov (United States)

    Wagner, V.; Suchopár, M.; Vrzalová, J.; Chudoba, P.; Svoboda, O.; Tichý, P.; Krása, A.; Majerle, M.; Kugler, A.; Adam, J.; Baldin, A.; Furman, W.; Kadykov, M.; Solnyshkin, A.; Tsoupko-Sitnikov, S.; Tyutyunikov, S.; Vladimirovna, N.; Závorka, L.

    2016-06-01

    Improvements of the Monte Carlo transport codes and cross-section libraries are very important steps towards usage of the accelerator-driven transmutation systems. We have conducted a lot of benchmark experiments with different set-ups consisting of lead, natural uranium and moderator irradiated by relativistic protons and deuterons within framework of the collaboration “Energy and Transmutation of Radioactive Waste”. Unfortunately, the knowledge of the total or partial cross-sections of important reactions is insufficient. Due to this reason we have started extensive studies of different reaction cross-sections. We measure cross-sections of important neutron reactions by means of the quasi-monoenergetic neutron sources based on the cyclotrons at Nuclear Physics Institute in Řež and at The Svedberg Laboratory in Uppsala. Measurements of partial cross-sections of relativistic deuteron reactions were the second direction of our studies. The new results obtained during last years will be shown. Possible use of these data for improvement of libraries, models and benchmark studies will be discussed.

  18. Self-consistent 2-phase AGN torus models: SED library for observers

    CERN Document Server

    Siebenmorgen, Ralf; Efstathiou, Andreas

    2015-01-01

    We assume that dust near active galactic nuclei (AGN) is distributed in a torus-like geometry, which may be described by a clumpy medium or a homogeneous disk or as a combination of the two (i.e. a 2-phase medium). The dust particles considered are fluffy and have higher submillimeter emissivities than grains in the diffuse ISM. The dust-photon interaction is treated in a fully self-consistent three dimensional radiative transfer code. We provide an AGN library of spectral energy distributions (SEDs). Its purpose is to quickly obtain estimates of the basic parameters of the AGN, such as the intrinsic luminosity of the central source, the viewing angle, the inner radius, the volume filling factor and optical depth of the clouds, and the optical depth of the disk midplane, and to predict the flux at yet unobserved wavelengths. The procedure is simple and consists of finding an element in the library that matches the observations. We discuss the general properties of the models and in particular the 10mic. silic...

  19. Models for blisks with large blends and small mistuning

    Science.gov (United States)

    Tang, Weihan; Epureanu, Bogdan I.; Filippi, Sergio

    2017-03-01

    Small deviations of the structural properties of individual sectors of blisks, referred to as mistuning, can lead to localization of vibration energy and drastically increased forced responses. Similar phenomena are observed in blisks with large damages or repair blends. Such deviations are best studied statistically because they are random. In the absence of cyclic symmetry, the computational cost to predict the vibration behavior of blisks becomes prohibitively high. That has lead to the development of various reduced-order models (ROMs). Existing approaches are either for small mistuning, or are computationally expensive and thus not effective for statistical analysis. This paper discusses a reduced-order modeling method for blisks with both large and small mistuning, which requires low computational effort. This method utilizes the pristine, rogue and interface modal expansion (PRIME) method to model large blends. PRIME uses only sector-level cyclic modes strategically combined together to create a reduction basis which yields ROMs that efficiently and accurately model large mistuning. To model small mistuning, nodal energy weighted transformation (NEWT) is integrated with PRIME, resulting in N-PRIME, which requires only sector-level calculations to create a ROM which captures both small and large mistuning with minimized computational effort. The combined effects of large blends and small mistuning are studied using N-PRIME for a dual flow path system and for a conventional blisk. The accuracy of the N-PRIME method is validated against full-order finite element analyses for both natural and forced response computations, including displacement amplitudes and surface stresses. Results reveal that N-PRIME is capable of accurately predicting the dynamics of a blisk with severely large mistuning, along with small random mistuning throughout each sector. Also, N-PRIME can accurately capture modes with highly localized motions. A statistical analysis is performed to

  20. A semi-empirical library of galaxy spectra for Gaia classification based on SDSS data and PÉGASE models

    Science.gov (United States)

    Tsalmantza, P.; Karampelas, A.; Kontizas, M.; Bailer-Jones, C. A. L.; Rocca-Volmerange, B.; Livanou, E.; Bellas-Velidis, I.; Kontizas, E.; Vallenari, A.

    2012-01-01

    Aims: This paper is the third in a series implementing a classification system for Gaia observations of unresolved galaxies. The system makes use of template galaxy spectra in order to determine spectral classes and estimate intrinsic astrophysical parameters. In previous work we used synthetic galaxy spectra produced by PÉGASE.2 code to simulate Gaia observations and to test the performance of support vector machine (SVM) classifiers and parametrizers. Here we produce a semi-empirical library of galaxy spectra by fitting SDSS spectra with the previously produced synthetic libraries. We present (1) the semi-empirical library of galaxy spectra; (2) a comparison between the observed and synthetic spectra; and (3) first results of classification and parametrization experiments with simulated Gaia spectrophotometry of this library. Methods: We use χ2-fitting to fit SDSS galaxy spectra with the synthetic library in order to construct a semi-empirical library of galaxy spectra in which (1) the real spectra are extended by the synthetic ones in order to cover the full wavelength range of Gaia; and (2) astrophysical parameters are assigned to the SDSS spectra by the best fitting synthetic spectrum. The SVM models were trained with and applied to semi-empirical spectra. Tests were performed for the classification of spectral types and the estimation of the most significant galaxy parameters (in particular redshift, mass to light ratio and star formation history). Results: We produce a semi-empirical library of 33 670 galaxy spectra covering the wavelength range 250 to 1050 nm at a sampling of 1 nm or less. Using the results of the fitting of the SDSS spectra with our synthetic library, we investigate the range of the input model parameters that produces spectra which are in good agreement with observations. In general the results are very good for the majority of the synthetic spectra of early type, spiral and irregular galaxies, while they reveal problems in the models

  1. A small world model for the spread of HIV infection

    Directory of Open Access Journals (Sweden)

    Israel T. Vieira

    2011-08-01

    Full Text Available It has long been recognised that the structure of social networks plays an important role in the dynamics of disease propagation. The spread of HIV usually results from a complex network of social interactions and other factors related to culture, sexual behaviour, demography, geography and disease characteristics, as well as the availability, accessibility and delivery of healthcare. The small world phenomenon has been used for representing social network interactions. It states that, given some random connections, the degrees of separation between any two individuals within a population can be very small. In this paper we present a discrete event simulation model which uses a variant of the small world network model to represent social interactions and the sexual transmission of HIV within a population. We use the model to demonstrate the importance of the choice of topology and initial distribution of infection, and capture the direct and non-linear relationship between the probability of a casual partnership (small world randomness parameter and the spread of HIV.

  2. Small signal frequency domain model of an HVDC converter

    Energy Technology Data Exchange (ETDEWEB)

    Osauskas, C.M.; Hume, D.J.; Wood, A.R. [UnIversity of Canterbury, Christchurch (New Zealand). Dept. of Electrical and Electronic Engineering

    2001-11-01

    A small-signal analytic frequency domain model of a 6-pulse HVDC converter is presented. The model consists of a set of explicit algebraic equations which relate the transfer of distortion from AC voltage, DC current and firing angle modulation, to AC current and DC voltage. The equations represent the linearisation of the transfers around a base operating point, and are derived from a piecewise linear description of the AC current and DC voltage waveforms. The model provides an understanding of the transfer of distortion by the converter and is in excellent agreement with time domain simulations. (author)

  3. Prediction Model for Bankruptcy in Micro and Small Enterprises (MSEs

    Directory of Open Access Journals (Sweden)

    Magda Gabriela Sánchez Trujillo

    2014-07-01

    Full Text Available The main purpose of this research is to validate and improve the Weighted Ratio Valuation Model (RPV model in micro and small enterprises in Central Mexico, in order to propose an alternative to financial valuation methods to anticipate bankruptcy in this sector of the economy. To achieve this objective, the study proposes the empirical application of Mosqueda 2010. The results shed important information that allowed the identification of variables that lead to bankruptcy, making risk detection more accurate, which, in turn, made it possible to validate and consolidate the model. 1024x768 Normal 0 21 false false false

  4. Corona graphs as a model of small-world networks

    Science.gov (United States)

    Lv, Qian; Yi, Yuhao; Zhang, Zhongzhi

    2015-11-01

    We introduce recursive corona graphs as a model of small-world networks. We investigate analytically the critical characteristics of the model, including order and size, degree distribution, average path length, clustering coefficient, and the number of spanning trees, as well as Kirchhoff index. Furthermore, we study the spectra for the adjacency matrix and the Laplacian matrix for the model. We obtain explicit results for all the quantities of the recursive corona graphs, which are similar to those observed in real-life networks.

  5. Modeling and Parameter Estimation of a Small Wind Generation System

    Directory of Open Access Journals (Sweden)

    Carlos A. Ramírez Gómez

    2013-11-01

    Full Text Available The modeling and parameter estimation of a small wind generation system is presented in this paper. The system consists of a wind turbine, a permanent magnet synchronous generator, a three phase rectifier, and a direct current load. In order to estimate the parameters wind speed data are registered in a weather station located in the Fraternidad Campus at ITM. Wind speed data were applied to a reference model programed with PSIM software. From that simulation, variables were registered to estimate the parameters. The wind generation system model together with the estimated parameters is an excellent representation of the detailed model, but the estimated model offers a higher flexibility than the programed model in PSIM software.

  6. Library rooms or Library halls

    Directory of Open Access Journals (Sweden)

    Alfredo Serrai

    2013-12-01

    windows from which the light was supposed to come, left free space at the centre of the hall, where the desks, statues, globes and astrolabes were placed. A new flourishing of library rooms according to this view was largely due to the genius of Francesco Borromini, who designed and built the Hall of the Library Vallicelliana modeled on the one of the Barberina Library, and then subsequently worked at the Hall of the library of the Sapienza, the Innocenziana and the Pamphilia. Borromini was therfore the main force behind some of the major projects of Saloni of the Baroque, and his architectural solutions became a paradigm for the design of such environments. In the following centuries, many Library Halls were built troughout Europe, increasingly differentiating each other both for the celebratory function of their collections, and for their role as testimony of civilization and culture of the time in which they arose.

  7. Modeling the Non-Linear Behavior of Library Cells for an Accurate Static Noise Analysis

    CERN Document Server

    Forzan, Cristiano

    2011-01-01

    In signal integrity analysis, the joint effect of propagated noise through library cells, and of the noise injected on a quiet net by neighboring switching nets through coupling capacitances, must be considered in order to accurately estimate the overall noise impact on design functionality and performances. In this work the impact of the cell non-linearity on the noise glitch waveform is analyzed in detail, and a new macromodel that allows to accurately and efficiently modeling the non-linear effects of the victim driver in noise analysis is presented. Experimental results demonstrate the effectiveness of our method, and confirm that existing noise analysis approaches based on linear superposition of the propagated and crosstalk-injected noise can be highly inaccurate, thus impairing the sign-off functional verification phase.

  8. A small-world network model of facial emotion recognition.

    Science.gov (United States)

    Takehara, Takuma; Ochiai, Fumio; Suzuki, Naoto

    2016-01-01

    Various models have been proposed to increase understanding of the cognitive basis of facial emotions. Despite those efforts, interactions between facial emotions have received minimal attention. If collective behaviours relating to each facial emotion in the comprehensive cognitive system could be assumed, specific facial emotion relationship patterns might emerge. In this study, we demonstrate that the frameworks of complex networks can effectively capture those patterns. We generate 81 facial emotion images (6 prototypes and 75 morphs) and then ask participants to rate degrees of similarity in 3240 facial emotion pairs in a paired comparison task. A facial emotion network constructed on the basis of similarity clearly forms a small-world network, which features an extremely short average network distance and close connectivity. Further, even if two facial emotions have opposing valences, they are connected within only two steps. In addition, we show that intermediary morphs are crucial for maintaining full network integration, whereas prototypes are not at all important. These results suggest the existence of collective behaviours in the cognitive systems of facial emotions and also describe why people can efficiently recognize facial emotions in terms of information transmission and propagation. For comparison, we construct three simulated networks--one based on the categorical model, one based on the dimensional model, and one random network. The results reveal that small-world connectivity in facial emotion networks is apparently different from those networks, suggesting that a small-world network is the most suitable model for capturing the cognitive basis of facial emotions.

  9. Scaling and percolation in the small-world network model

    Energy Technology Data Exchange (ETDEWEB)

    Newman, M. E. J. [Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, New Mexico 87501 (United States); Watts, D. J. [Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, New Mexico 87501 (United States)

    1999-12-01

    In this paper we study the small-world network model of Watts and Strogatz, which mimics some aspects of the structure of networks of social interactions. We argue that there is one nontrivial length-scale in the model, analogous to the correlation length in other systems, which is well-defined in the limit of infinite system size and which diverges continuously as the randomness in the network tends to zero, giving a normal critical point in this limit. This length-scale governs the crossover from large- to small-world behavior in the model, as well as the number of vertices in a neighborhood of given radius on the network. We derive the value of the single critical exponent controlling behavior in the critical region and the finite size scaling form for the average vertex-vertex distance on the network, and, using series expansion and Pade approximants, find an approximate analytic form for the scaling function. We calculate the effective dimension of small-world graphs and show that this dimension varies as a function of the length-scale on which it is measured, in a manner reminiscent of multifractals. We also study the problem of site percolation on small-world networks as a simple model of disease propagation, and derive an approximate expression for the percolation probability at which a giant component of connected vertices first forms (in epidemiological terms, the point at which an epidemic occurs). The typical cluster radius satisfies the expected finite size scaling form with a cluster size exponent close to that for a random graph. All our analytic results are confirmed by extensive numerical simulations of the model. (c) 1999 The American Physical Society.

  10. 论新信息环境下中小型图书馆信息资源建设%Discussion on Information Resources Construction of Small and Medium-sized Libraries in the New Information Environment

    Institute of Scientific and Technical Information of China (English)

    叶菁

    2015-01-01

    论述了新信息环境下中小型图书馆信息资源建设的定位,探讨了新信息环境下中小型图书馆信息资源建设的有效对策.%This paper discusses the positioning of information resources construction of small and medium-sized libraries in the new information environment, and probes into some effective countermeasures for small and medium-sized libraries to carry out the information resources construction in new information environment.

  11. Quasi-Bayesian software reliability model with small samples

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jin; TU Jun-xiang; CHEN Zhuo-ning; YAN Xiao-guang

    2009-01-01

    In traditional Bayesian software reliability models,it was assume that all probabilities are precise.In practical applications the parameters of the probability distributions are often under uncertainty due to strong dependence on subjective information of experts' judgments on sparse statistical data.In this paper,a quasi-Bayesian software reliability model using interval-valued probabilities to clearly quantify experts' prior beliefs on possible intervals of the parameters of the probability distributions is presented.The model integrates experts' judgments with statistical data to obtain more convincible assessments of software reliability with small samples.For some actual data sets,the presented model yields better predictions than the Jelinski-Moranda (JM) model using maximum likelihood (ML).

  12. Digestion modeling in the small intestine: impact of dietary fiber.

    Science.gov (United States)

    Taghipoor, M; Barles, G; Georgelin, C; Licois, J R; Lescoat, P

    2014-12-01

    In this work, the modeling of the digestion in the small intestine is developed by investigating specifically the effects of dietary fiber. As our previous model, this new version takes into account the three main phenomena of digestion: transit of the bolus, degradation of feedstuffs and absorption through the intestinal wall. However the two main physiochemical characteristics of dietary fiber, namely viscosity and water holding capacity, lead us to substantially modify our initial model by emphasizing the role of water and its intricated dynamics with dry matter in the bolus. Various numerical simulations given by this new model are qualitatively in agreement with the positive effect of insoluble dietary fiber on the velocity of bolus and on its degradation all along the small intestine. These simulations reproduce the negative effect of soluble dietary fiber on digestion as it has been experimentally observed. Although, this model is generic and contains a large number of parameters but, to the best of our knowledge, it is among the first qualitative dynamical models of fiber influence on intestinal digestion.

  13. Thermal Model Description of Collisions of Small Nuclei

    CERN Document Server

    Cleymans, J.; Oeschler, H.; Redlich, K.; Sharma, N.

    2016-01-01

    The dependence of particle production on the size of the colliding nuclei is analyzed in terms of the thermal model using the canonical ensemble. The concept of strangeness correlation in clusters of sub-volume $V_c$ is used to account for the suppression of strangeness. A systematic analysis is presented of the predictions of the thermal model for particle production in collisions of small nuclei. The pattern of the maxima in particle ratios of strange particles to pions as a function of beam energy is quite special, as they do not occur at the same beam energy and are sensitive to system size. In particular, the $\\Lambda/\\pi^+$ ratio shows a clear maximum even for the smallest systems while the maximum in the K$^+/\\pi^+$ ratio disappears in small systems.

  14. DEVELOPMENT MODEL OF UNDER DEVELOPED SMALL ISLAND IN SUMENEP

    Directory of Open Access Journals (Sweden)

    Sudarti Sudarti

    2011-09-01

    Full Text Available The purpose of this study is to build a Geographic Information System and Management Information System models of development of small islands in Sumenep. Based on the identification of economic potential there are few regions such as Nonggunong, Gayam, Ra'as, and Sapeken which have large contribution toward the rice plant production. The whole districts of the islands in Sumenep are the base of cow, horse, chicken and livestock commodities. Sapeken have significant contribution for marine fish. Giligenting, Nonggunong, Gayam, and Arjasa have large potential for brackish fish. Moreover, Gili-genting also has a great contribution for fresh fish.Keywords: Development model, under-developed area, small islandsJEL classification numbers: O13, O14

  15. Populating a Library of Reusable H-Boms Assessment of a Feasible Image Based Modeling Workflow

    Science.gov (United States)

    Santagati, C.; Lo Turco, M.; D'Agostino, G.

    2017-08-01

    The paper shows the intermediate results of a research activity aimed at populating a library of reusable Historical Building Object Models (H-BOMs) by testing a full digital workflow that takes advantages from using Structure from Motion (SfM) models and is centered on the geometrical/stylistic/materic analysis of the architectural element (portal, window, altar). The aim is to find common (invariant) and uncommon (variant) features in terms of identification of architectural parts and their relationships, geometrical rules, dimensions and proportions, construction materials and measure units, in order to model archetypal shapes from which it is possible to derive all the style variations. At this regard, a set of 14th - 16th century gothic portals of the catalan-aragonese architecture in Etnean area of Eastern Sicily has been studied and used to assess the feasibility of the identified workflow. This approach tries to answer the increasingly demand for guidelines and standards in the field of Cultural Heritage Conservation to create and manage semantic-aware 3D models able to include all the information (both geometrical and alphanumerical ones) concerning historical buildings and able to be reused in several projects.

  16. A Revised Model for Dosimetry in the Human Small Intestine

    Energy Technology Data Exchange (ETDEWEB)

    John Poston; Nasir U. Bhuiyan; R. Alex Redd; Neil Parham; Jennifer Watson

    2005-02-28

    A new model for an adult human gastrointestinal tract (GIT) has been developed for use in internal dose estimations to the wall of the GIT and to the other organs and tissues of the body from radionuclides deposited in the lumenal contents of the five sections of the GIT. These sections were the esophasgus, stomach, small intestine, upper large intestine, and the lower large intestine. The wall of each section was separated from its lumenal contents.

  17. Digestion Modelling in the Small Intestine : Impact of Dietary Fibre

    CERN Document Server

    Taghipoor, Masoomeh; Georgelin, Christine; Licois, Jean-René; Lescoat, Philippe

    2012-01-01

    In this work, we continue the modelling of the digestion in the small intestine, started in a previous article, by investigating the effects of dietary fibre. We recall that this model aims at taking into account the three main phenomena of the digestion, namely the transit of the bolus, the degradation of feedstuffs and the absorption through the intestinal wall. In order to study the role of dietary fibre on digestion, we model their two principal physiochemical characteristics which interact with the function of the small intestine, i.e. viscosity and water holding capacity. This leads us to consider some features of digestion which have not been taken into account previously, in particular the interrelationship between the evolution of dry matter and water in the bolus. The numerical results are in agreement with the positive effect of insoluble dietary fibre on the velocity of bolus along the small intestine and on its degradation. These results highlight the negative effect of soluble dietary fibre on d...

  18. Modelling small-patterned neuronal networks coupled to microelectrode arrays

    Science.gov (United States)

    Massobrio, Paolo; Martinoia, Sergio

    2008-09-01

    Cultured neurons coupled to planar substrates which exhibit 'well-defined' two-dimensional network architectures can provide valuable insights into cell-to-cell communication, network dynamics versus topology, and basic mechanisms of synaptic plasticity and learning. In the literature several approaches were presented to drive neuronal growth, such as surface modification by silane chemistry, photolithographic techniques, microcontact printing, microfluidic channel flow patterning, microdrop patterning, etc. This work presents a computational model fit for reproducing and explaining the dynamics exhibited by small-patterned neuronal networks coupled to microelectrode arrays (MEAs). The model is based on the concept of meta-neuron, i.e., a small spatially confined number of actual neurons which perform single macroscopic functions. Each meta-neuron is characterized by a detailed morphology, and the membrane channels are modelled by simple Hodgkin-Huxley and passive kinetics. The two main findings that emerge from the simulations can be summarized as follows: (i) the increasing complexity of meta-neuron morphology reflects the variations of the network dynamics as a function of network development; (ii) the dynamics displayed by the patterned neuronal networks considered can be explained by hypothesizing the presence of several short- and a few long-term distance interactions among small assemblies of neurons (i.e., meta-neurons).

  19. Model Predictive Control for a Small Scale Unmanned Helicopter

    Directory of Open Access Journals (Sweden)

    Jianfu Du

    2008-11-01

    Full Text Available Kinematical and dynamical equations of a small scale unmanned helicoper are presented in the paper. Based on these equations a model predictive control (MPC method is proposed for controlling the helicopter. This novel method allows the direct accounting for the existing time delays which are used to model the dynamics of actuators and aerodynamics of the main rotor. Also the limits of the actuators are taken into the considerations during the controller design. The proposed control algorithm was verified in real flight experiments where good perfomance was shown in postion control mode.

  20. Point process models for household distributions within small areal units

    Directory of Open Access Journals (Sweden)

    Zack W. Almquist

    2012-06-01

    Full Text Available Spatio-demographic data sets are increasingly available worldwide, permitting ever more realistic modeling and analysis of social processes ranging from mobility to disease trans- mission. The information provided by these data sets is typically aggregated by areal unit, for reasons of both privacy and administrative cost. Unfortunately, such aggregation does not permit fine-grained assessment of geography at the level of individual households. In this paper, we propose to partially address this problem via the development of point pro- cess models that can be used to effectively simulate the location of individual households within small areal units.

  1. Small velocity and finite temperature variations in kinetic relaxation models

    KAUST Repository

    Markowich, Peter

    2010-01-01

    A small Knuden number analysis of a kinetic equation in the diffusive scaling is performed. The collision kernel is of BGK type with a general local Gibbs state. Assuming that the flow velocity is of the order of the Knudsen number, a Hilbert expansion yields a macroscopic model with finite temperature variations, whose complexity lies in between the hydrodynamic and the energy-transport equations. Its mathematical structure is explored and macroscopic models for specific examples of the global Gibbs state are presented. © American Institute of Mathematical Sciences.

  2. ORDEM2010 and MASTER-2009 Modeled Small Debris Population Comparison

    Science.gov (United States)

    Krisko, Paula H.; Flegel, S.

    2010-01-01

    The latest versions of the two premier orbital debris engineering models, NASA s ORDEM2010 and ESA s MASTER-2009, have been publicly released. Both models have gone through significant advancements since inception, and now represent the state-of-the-art in orbital debris knowledge of their respective agencies. The purpose of these models is to provide satellite designers/operators and debris researchers with reliable estimates of the artificial debris environment in near-Earth orbit. The small debris environment within the size range of 1 mm to 1 cm is of particular interest to both human and robotic spacecraft programs. These objects are much more numerous than larger trackable debris but are still large enough to cause significant, if not catastrophic, damage to spacecraft upon impact. They are also small enough to elude routine detection by existing observation systems (radar and telescope). Without reliable detection the modeling of these populations has always coupled theoretical origins with supporting observational data in different degrees. This paper details the 1 mm to 1 cm orbital debris populations of both ORDEM2010 and MASTER-2009; their sources (both known and presumed), current supporting data and theory, and methods of population analysis. Fluxes on spacecraft for chosen orbits are also presented and discussed within the context of each model.

  3. Loss-improved electroacoustical modeling of small Helmholtz resonators.

    Science.gov (United States)

    Starecki, Tomasz

    2007-10-01

    Modeling of small Helmholtz resonators based on electroacoustical analogies often results in significant disagreement with measurements, as existing models do not take into account some losses that are observed in practical implementations of such acoustical circuits, e.g., in photoacoustic Helmholtz cells. The paper presents a method which introduces loss corrections to the transmission line model, resulting in substantial improvement of simulations. Values of the loss corrections obtained from comparison of frequency responses of practically implemented resonators with computer simulations are presented in tabular and graphical form. A simple analytical function that can be used for interpolation or extrapolation of the loss corrections for other dimensions of the Helmholtz resonators is also given. Verification of such a modeling method against an open two-cavity Helmholtz structure shows very good agreement between measurements and simulations.

  4. Conceptualising 'knowledge management' in the context of library and information science using the core/periphery model

    Directory of Open Access Journals (Sweden)

    O.B. Onyancha

    2009-04-01

    Full Text Available This study took cognisance of the fact that the term 'knowledge management' lacks a universally accepted definition, and consequently sought to describe the term using the most common co-occurring terms in knowledge management (KM literature as indexed in the Library, Information Science and Technology Abstracts (LISTA database. Using a variety of approaches and analytic techniques (e.g. core/periphery analysis and co-occurrence of words as subject terms, data were analysed using the core/periphery model and social networks through UCINET for Windows, TI, textSTAT and Bibexcel computer-aided software. The study identified the following as the compound terms with which KM co-occurs most frequently: information resources management, information science, information technology, information services, information retrieval, library science, management information systems and libraries. The core single subject terms with which KM can be defined include resources, technology, libraries, systems, services, retrieval, storage, data and computers. The article concludes by offering the library and information science (LIS professionals' general perception of KM based on their use of terms, through which KM can be defined within the context of LIS.

  5. A New Theoretical Library of High-resolution Stellar Spectra for UV-Optical Population Synthesis Models

    Science.gov (United States)

    Bertone, E.; Rodriguez-Merino, L.; Chavez, M.; Buzzoni, A.

    2003-06-01

    We present a new theoretical library of stellar spectra covering the wavelength interval from 850 to 7000 Å. The library consists of two datasets, one including the far UV-blue spectral region from 850 to 4750 Å at inverse spectral resolution R = 50000, and the latter spanning the range 3500-7000 Å at R = 500000. Both sets are based on the SYNTHE series of codes developed by R.L. Kurucz. For its comprehensive range of physical parameters (i.e. T[eff], logg and [M/H]) and higher spectral resolution, this is the most advanced spectral library currently available in the literature, and could profitably be used for population synthesis models and abundance studies of single stars.

  6. Determining Criteria to Measuring of the E-readiness Level of Academic Libraries Based of IUP Model

    Directory of Open Access Journals (Sweden)

    Yaghoub Norouzi

    2012-03-01

    Full Text Available Preparation of a community or organization to take part and benefit from development of information and communication technology defined as e-readiness. The aim of this study was determining criteria to measuring of the e-readiness level of academic libraries. In this regard, the published literature in the field of e-readiness reviewed, and eventually the IUP (Information Utilization Potential model cited as a reference. Then, using the Delphi method and library and information science experts' help, e-readiness assessment indicators were presented for academic libraries. After customization and performing statistical analysis, indicators in the form of five basic dimensions (including the organization and management, human resources, data, information and communication technologies, and the relationship with the environment, including 82 sub-criteria confirmed. It was hope that the results of current research findings to bring the right tool for the custodians and researchers.

  7. A Model for Managing 3D Printing Services in Academic Libraries

    Science.gov (United States)

    Scalfani, Vincent F.; Sahib, Josh

    2013-01-01

    The appearance of 3D printers in university libraries opens many opportunities for advancing outreach, teaching, and research programs. The University of Alabama (UA) Libraries recently adopted 3D printing technology and maintains an open access 3D Printing Studio. The Studio consists of a 3D printer, multiple 3D design workstations, and other…

  8. A Basic Hybrid Library Support Model to Distance Learners in Sudan

    Science.gov (United States)

    Abdelrahman, Omer Hassan

    2012-01-01

    Distance learning has flourished in Sudan during the last two decades; more and more higher education institutions offer distance learning programmes to off-campus students. Like on-campus students, distance learners should have access to appropriate library and information support services. They also have specific needs for library and…

  9. Accessibility, Collaboration, and Staffing: Revamping the Model for Academic Library Video Collections

    Science.gov (United States)

    McGeary, Bryan James

    2015-01-01

    This column contains information on how students in graduate library and information science programs participate in a forum to discuss key issues they see in academic library public services, to envision what they feel librarians in public service have to offer to academia, to state their visions for the profession, or to tell of research that is…

  10. A Model for Assessing the Service Quality of University Library Websites

    Directory of Open Access Journals (Sweden)

    Chung-Min Wu

    2013-01-01

    Full Text Available Evaluating the e-service quality is essential to organizations. The future of e-libraries has a vital place in universities. Libraries need to use websites as means to provide access to information resources, news and events. The importance of assessing e-service quality of libraries is significant. Previous researchers have developed many methods for assessing e-service quality. However, most of them only focus on the independent hierarchical structure. In this paper, we would like to figure out the criteria for assessing the service quality of library websites from university students’ viewpoints. According to interdependent criteria, the analytic network process (ANP approach is employed to (i generate the priority weights of each criterion; (ii measure the service quality of university library websites. 12 web-based service criteria are identified according to 3144 university students’ viewpoints based on fuzzy Delphi method. On the basis of past studies, we divide 12 criteria into 3 perspectives, namely, system, efficiency, and information quality to measure the service quality of university library websites. On the basis of 3 perspectives and 12 important criteria, service quality of university library websites could be measured more effectively. Moreover, the practical application to measure the service quality of the old and new versions of one university library website presented in Section 5 is generic and also suitable to be exploited for Taiwanese universities.

  11. A Model for Managing 3D Printing Services in Academic Libraries

    Science.gov (United States)

    Scalfani, Vincent F.; Sahib, Josh

    2013-01-01

    The appearance of 3D printers in university libraries opens many opportunities for advancing outreach, teaching, and research programs. The University of Alabama (UA) Libraries recently adopted 3D printing technology and maintains an open access 3D Printing Studio. The Studio consists of a 3D printer, multiple 3D design workstations, and other…

  12. 图书馆移动服务模式研究%Research on the Mobile Service Model of Libraries

    Institute of Scientific and Technical Information of China (English)

    谢强; 牛现云; 赵娜; 高宏

    2012-01-01

    目前,图书馆移动服务主要实现方式为短(彩)信方式、基于浏览器的服务方式、客户端(移动)应用程序,服务内容主要有续借、预约等图书流通相关服务及信息公告、移动阅读等。但是无论从实现技术还是服务内容来看,服务模式都具有一定的局限性。因此,从发展角度及广泛适用性来看,图书馆移动服务模式应该包括延伸型图书馆移动服务、单一型图书馆移动服务、融合型图书馆移动服务。%At present,mobile services of libraries are mainly implemented by short(multimedia) message services,browser-based services and the client Application(APP).The mobile service content of libraries primarily includes book circulation services such as renew and booking,information bulletin,mobile reading,and so on.However,no matter in the view of implementation technique or service content,there are certain limitations to mobile service models.The mobile service model of libraries should be considered from development perspective,as well as extensive applicability,it should include extended type mobile services of libraries,single type mobile services of libraries,mobile services of libraries based on the network convergence.

  13. Modeling impact of small Kansas landfills on underlying aquifers

    Science.gov (United States)

    Sophocleous, M.; Stadnyk, N.G.; Stotts, M.

    1996-01-01

    Small landfills are exempt from compliance with Resource Conservation and Recovery Act Subtitle D standards for liner and leachate collection. We investigate the ramifications of this exemption under western Kansas semiarid environments and explore the conditions under which naturally occurring geologic settings provide sufficient protection against ground-water contamination. The methodology we employed was to run water budget simulations using the Hydrologic Evaluation of Landfill Performance (HELP) model, and fate and transport simulations using the Multimedia Exposure Assessment Model (MULTIMED) for several western Kansas small landfill scenarios in combination with extensive sensitivity analyses. We demonstrate that requiring landfill cover, leachate collection system (LCS), and compacted soil liner will reduce leachate production by 56%, whereas requiring only a cover without LCS and liner will reduce leachate by half as much. The most vulnerable small landfills are shown to be the ones with no vegetative cover underlain by both a relatively thin vadose zone and aquifer and which overlie an aquifer characterized by cool temperatures and low hydraulic gradients. The aquifer-related physical and chemical parameters proved to be more important than vadose zone and biodegradation parameters in controlling leachate concentrations at the point of compliance. ??ASCE.

  14. Approach to General Data Model of GIS Symbol Library and Symbol Library Data Exchange XML Schema%GIS符号库通用数据模型及其数据交换格式的研究

    Institute of Scientific and Technical Information of China (English)

    李青元; 苏德国; 李洪省; 刘皓晨; 孙立坚

    2009-01-01

    Symbol portrayal is an important function of GIS.Sharing symbolic information in different GIS platforms is neces-sary for GIS applications and users.This paper discusses the necessity,possibility and solution technique of sharing a symbol library in different GIS platforms.The route map is designed as follows:first,to set up a general data model for the symbol li-brary,then to design a standard exchange format,and finally to call on the GIS manufacturer to provide the interchange tools for their symbol library for the standard exchange format.This paper analyzes the general characteristics of GIS symbolic li-brary,gives a symbol library model and a draft of XML schema of the symbol library exchange format.

  15. A simple physical model predicts small exon length variations.

    Directory of Open Access Journals (Sweden)

    2006-04-01

    Full Text Available One of the most common splice variations are small exon length variations caused by the use of alternative donor or acceptor splice sites that are in very close proximity on the pre-mRNA. Among these, three-nucleotide variations at so-called NAGNAG tandem acceptor sites have recently attracted considerable attention, and it has been suggested that these variations are regulated and serve to fine-tune protein forms by the addition or removal of a single amino acid. In this paper we first show that in-frame exon length variations are generally overrepresented and that this overrepresentation can be quantitatively explained by the effect of nonsense-mediated decay. Our analysis allows us to estimate that about 50% of frame-shifted coding transcripts are targeted by nonsense-mediated decay. Second, we show that a simple physical model that assumes that the splicing machinery stochastically binds to nearby splice sites in proportion to the affinities of the sites correctly predicts the relative abundances of different small length variations at both boundaries. Finally, using the same simple physical model, we show that for NAGNAG sites, the difference in affinities of the neighboring sites for the splicing machinery accurately predicts whether splicing will occur only at the first site, splicing will occur only at the second site, or three-nucleotide splice variants are likely to occur. Our analysis thus suggests that small exon length variations are the result of stochastic binding of the spliceosome at neighboring splice sites. Small exon length variations occur when there are nearby alternative splice sites that have similar affinity for the splicing machinery.

  16. Library system of Italy

    Directory of Open Access Journals (Sweden)

    Nataša Gerbec

    2003-01-01

    Full Text Available In the European extent, Italy is the cradle of libraries and library sciences. In the past, Italian national public libraries played an important role through their vast book treasury. But only during the last thirty years have public libraries been developed following the Anglo-American public library model. Italy does not have any uniform or general legislation concerning libraries. On the state level, this area is regulated by some separate acts, while on the regional level there is a collection of various acts and regulations. Libraries are not strictly divided into general categories. It is required that the professionals engaged in Italian libraries should have secondary or university education. The level of their professional tasks depends on the type of library and its capacity. The competency for the development in the field of librarianship is assigned to The Ministry of Cultural and Environment Heritage as well as to its subordinate institutions (Central Institute for the Union catalogue of Italian Libraries and for Bibliographic Information, Central Institute for Book Pathology, Observatory for International Libraries Programmes.

  17. Development of a system model for advanced small modular reactors.

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, Tom Goslee,; Holschuh, Thomas Vernon,

    2014-01-01

    This report describes a system model that can be used to analyze three advance small modular reactor (SMR) designs through their lifetime. Neutronics of these reactor designs were evaluated using Monte Carlo N-Particle eXtended (MCNPX/6). The system models were developed in Matlab and Simulink. A major thrust of this research was the initial scoping analysis of Sandias concept of a long-life fast reactor (LLFR). The inherent characteristic of this conceptual design is to minimize the change in reactivity over the lifetime of the reactor. This allows the reactor to operate substantially longer at full power than traditional light water reactors (LWRs) or other SMR designs (e.g. high temperature gas reactor (HTGR)). The system model has subroutines for lifetime reactor feedback and operation calculations, thermal hydraulic effects, load demand changes and a simplified SCO2 Brayton cycle for power conversion.

  18. Design and modeling of an on-silicon spiral inductor library using improved EM simulations

    Science.gov (United States)

    Goni-Iturri, A.; Khemchandani, S. L.; del Pino, F. J.; Garcia, J.; Gonzalez, B.; Hernandez, A.

    2005-06-01

    This paper deals with the design and modeling of integrated spiral inductors for RF applications by means of a general purpose Electromagnetic (EM) simulator. These tools allow optimizing flexibly the inductor layout structure. The inductor performance can be obtained by using a three-dimensional design tool or a two-dimensional one. Planar 2-D or so called 2.5-Ds simulators are faster and accept complex coil geometries. We have used one of these simulators, the Advanced Design System planar EM simulator, Momentum, from Agilent. The inductor quality factor (Q) is limited, among other phenomena, by the series resistance of the metal traces and the substrate losses. Therefore the simulator requires an accurate set up of the process and simulator parameters and a correct algorithm to model metal thickness to rely on simulation results. In this paper we analyze and compare these different approaches. A high-quality factor inductor library on a 0.35 μm SiGe technology at 5 GHz is also designed in this work using the proper simulator set up. Nine of the inductors have been fabricated and measured to test the simulator reliability. Measurements taken over a frequency range from 500 MHz to 10GHz show a good agreement with 2.5-EM simulations.

  19. A distributed, collaborative, structuring model for a clinical-guideline digital-library.

    Science.gov (United States)

    Shahar, Yuval; Shalom, Erez; Mayaffit, Alon; Young, Ohad; Galperin, Maya; Martins, Susana; Goldstein, Mary

    2003-01-01

    The Digital Electronic Guideline Library (DeGeL) is a Web-based framework and a set of distributed tools that facilitate gradual conversion of clinical guidelines from free text, through semi-structured text, to a fully structured, executable representation. Thus, guidelines exist in a hybrid, multiple-format representation The three formats support increasingly sophisticated computational tasks. The tools perform semantic markup, classification, search, and browsing, and support computational modules that we are developing, for run-time application and retrospective quality assessment. We describe the DeGeL architecture and its collaborative-authoring authorization model, which is based on (1) multiple medical-specialty authoring groups, each including a group manager who controls group authorizations, and (2) a hierarchical authorization model based on the different functions involved in the hybrid guideline-specification process. We have implemented the core modules of the DeGeL architecture and demonstrated distributed markup and retrieval using the knowledge roles of two guidelines ontologies (Asbru and GEM). We are currently evaluating several of the DeGeL tools.

  20. Library Automation

    OpenAIRE

    Dhakne, B. N.; Giri, V. V.; Waghmode, S. S.

    2010-01-01

    New technologies library provides several new materials, media and mode of storing and communicating the information. Library Automation reduces the drudgery of repeated manual efforts in library routine. By use of library automation collection, Storage, Administration, Processing, Preservation and communication etc.

  1. The Modeling Library of Eavesdropping Methods in Quantum Cryptography Protocols by Model Checking

    Science.gov (United States)

    Yang, Fan; Yang, Guowu; Hao, Yujie

    2016-07-01

    The most crucial issue of quantum cryptography protocols is its security. There exists many ways to attack the quantum communication process. In this paper, we present a model checking method for modeling the eavesdropping in quantum information protocols. So when the security properties of a certain protocol are needed to be verified, we can directly use the models which are already built. Here we adopt the probabilistic model checking tool—PRISM to model these attack methods. The verification results show that the detection rate of eavesdropping is approximately close to 1 when enough photons are transmitted.

  2. Autonomous Navigation of Small Uavs Based on Vehicle Dynamic Model

    Science.gov (United States)

    Khaghani, M.; Skaloud, J.

    2016-03-01

    This paper presents a novel approach to autonomous navigation for small UAVs, in which the vehicle dynamic model (VDM) serves as the main process model within the navigation filter. The proposed method significantly increases the accuracy and reliability of autonomous navigation, especially for small UAVs with low-cost IMUs on-board. This is achieved with no extra sensor added to the conventional INS/GNSS setup. This improvement is of special interest in case of GNSS outages, where inertial coasting drifts very quickly. In the proposed architecture, the solution to VDM equations provides the estimate of position, velocity, and attitude, which is updated within the navigation filter based on available observations, such as IMU data or GNSS measurements. The VDM is also fed with the control input to the UAV, which is available within the control/autopilot system. The filter is capable of estimating wind velocity and dynamic model parameters, in addition to navigation states and IMU sensor errors. Monte Carlo simulations reveal major improvements in navigation accuracy compared to conventional INS/GNSS navigation system during the autonomous phase, when satellite signals are not available due to physical obstruction or electromagnetic interference for example. In case of GNSS outages of a few minutes, position and attitude accuracy experiences improvements of orders of magnitude compared to inertial coasting. It means that during such scenario, the position-velocity-attitude (PVA) determination is sufficiently accurate to navigate the UAV to a home position without any signal that depends on vehicle environment.

  3. Atmospheric dispersion modelling over complex terrain at small scale

    Science.gov (United States)

    Nosek, S.; Janour, Z.; Kukacka, L.; Jurcakova, K.; Kellnerova, R.; Gulikova, E.

    2014-03-01

    Previous study concerned of qualitative modelling neutrally stratified flow over open-cut coal mine and important surrounding topography at meso-scale (1:9000) revealed an important area for quantitative modelling of atmospheric dispersion at small-scale (1:3300). The selected area includes a necessary part of the coal mine topography with respect to its future expansion and surrounding populated areas. At this small-scale simultaneous measurement of velocity components and concentrations in specified points of vertical and horizontal planes were performed by two-dimensional Laser Doppler Anemometry (LDA) and Fast-Response Flame Ionization Detector (FFID), respectively. The impact of the complex terrain on passive pollutant dispersion with respect to the prevailing wind direction was observed and the prediction of the air quality at populated areas is discussed. The measured data will be used for comparison with another model taking into account the future coal mine transformation. Thus, the impact of coal mine transformation on pollutant dispersion can be observed.

  4. Increased diversity of libraries from libraries: chemoinformatic analysis of bis-diazacyclic libraries.

    Science.gov (United States)

    López-Vallejo, Fabian; Nefzi, Adel; Bender, Andreas; Owen, John R; Nabney, Ian T; Houghten, Richard A; Medina-Franco, José L

    2011-05-01

    Combinatorial libraries continue to play a key role in drug discovery. To increase structural diversity, several experimental methods have been developed. However, limited efforts have been performed so far to quantify the diversity of the broadly used diversity-oriented synthetic libraries. Herein, we report a comprehensive characterization of 15 bis-diazacyclic combinatorial libraries obtained through libraries from libraries, which is a diversity-oriented synthetic approach. Using MACCS keys, radial and different pharmacophoric fingerprints as well as six molecular properties, it was demonstrated the increased structural and property diversity of the libraries from libraries over the individual libraries. Comparison of the libraries to existing drugs, NCI diversity, and the Molecular Libraries Small Molecule Repository revealed the structural uniqueness of the combinatorial libraries (mean similarity <0.5 for any fingerprint representation). In particular, bis-cyclic thiourea libraries were the most structurally dissimilar to drugs retaining drug-like character in property space. This study represents the first comprehensive quantification of the diversity of libraries from libraries providing a solid quantitative approach to compare and contrast the diversity of diversity-oriented synthetic libraries with existing drugs or any other compound collection.

  5. Selected Aspects Of Modelling Of Non-Linear Behaviour Of Concrete During Tensile Test Using Multiplas Library

    Directory of Open Access Journals (Sweden)

    Hokeš Filip

    2015-12-01

    Full Text Available The subject of this paper is to describe some of the aspects manifesting in the use of the elastoplastic material model library multiPlas, which was developed to support non-linear computations in the ANSYS system. The text focuses on the analysis of numerical simulations of a virtual tension test in several case studies, thereby the text endeavours to describe the problems connected with modelling non-linear behaviour of concrete in a tensile area.

  6. Building a Scoring Model for Small and Medium Enterprises

    Directory of Open Access Journals (Sweden)

    Răzvan Constantin CARACOTA

    2010-09-01

    Full Text Available The purpose of the paper is to produce a scoring model for small and medium enterprises seeking financing through a bank loan. To analyze the loan application, scoring system developed for companies is as follows: scoring quantitative factors and scoring qualitative factors. We have estimated the probability of default using logistic regression. Regression coefficients determination was made with a solver in Excel using five ratios as input data. Analyses and simulations were conducted on a sample of 113 companies, all accepted for funding. Based on financial information obtained over two years, 2007 and 2008, we could establishe and appreciate the default value.

  7. Small-signal, continuous, exact model of PWM voltage regulators

    Science.gov (United States)

    Burkhardt, W.; Maranesi, P.; Varoli, V.

    1985-02-01

    The small-signal time-continuous open-loop response of buck, boost, and buck-boost pulse-width-modulation (PWM) voltage regulators using MOSFET switches in their power stages is modeled, applying a time-domain sampling theorem (Woodward, 1953) to obtain the Fourier open-loop transfer function corresponding to the comb function describing the response at the chopping instants only. The results are presented graphically along with simplified circuit diagrams of the PWM devices, and the accuracy and computational efficiency of the analytical approach are indicated.

  8. SWIM: A Simple Model to Generate Small Mobile Worlds

    CERN Document Server

    Mei, Alessandro

    2008-01-01

    This paper presents small world in motion (SWIM), a new mobility model for ad-hoc networking. SWIM is relatively simple, is easily tuned by setting just a few parameters, and generates traces that look real--synthetic traces have the same statistical properties of real traces. SWIM shows both experimentally and theoretically the presence of the power law and exponential decay dichotomy of inter-contact times, and, most importantly, our experiments show that it can predict very accurately the performance of forwarding protocols.

  9. SCHOOL COMMUNITY PERCEPTION OF LIBRARY APPS AGAINTS LIBRARY EMPOWERMENT

    Directory of Open Access Journals (Sweden)

    Achmad Riyadi Alberto

    2017-07-01

    Full Text Available Abstract. This research is motivated by the development of information and communication technology (ICT in the library world so rapidly that allows libraries in the present to develop its services into digital-based services. This study aims to find out the school community’s perception of library apps developed by Riche Cynthia Johan, Hana Silvana, and Holin Sulistyo and its influence on library empowerment at the library of SD Laboratorium Percontohan UPI Bandung. Library apps in this research belong to the context of m-libraries, which is a library that meets the needs of its users by using mobile platforms such as smartphones,computers, and other mobile devices. Empowerment of library is the utilization of all aspects of the implementation of libraries to the best in order to achieve the expected goals. An analysis of the schoolcommunity’s perception of library apps using the Technology Acceptance Model (TAM includes: ease of use, usefulness, usability, usage trends, and real-use conditions. While the empowerment of the library includes aspects: information empowerment, empowerment of learning resources, empowerment of human resources, empowerment of library facilities, and library promotion. The research method used in this research is descriptive method with quantitative approach. Population and sample in this research is school community at SD Laboratorium Percontohan UPI Bandung. Determination of sample criteria by using disproportionate stratified random sampling with the number of samples of 83 respondents. Data analysis using simple linear regression to measure the influence of school community perception about library apps to library empowerment. The result of data analysis shows that there is influence between school community perception about library apps to library empowerment at library of SD Laboratorium Percontohan UPI Bandung which is proved by library acceptance level and library empowerment improvement.

  10. Parameterization of small intestinal water volume using PBPK modeling.

    Science.gov (United States)

    Maharaj, Anil; Fotaki, Nikoletta; Edginton, Andrea

    2015-01-25

    To facilitate accurate predictions of oral drug disposition, mechanistic absorption models require optimal parameterization. Furthermore, parameters should maintain a biological basis to establish confidence in model predictions. This study will serve to calculate an optimal parameter value for small intestinal water volume (SIWV) using a model-based approach. To evaluate physiologic fidelity, derived volume estimates will be compared to experimentally-based SIWV determinations. A compartmental absorption and transit (CAT) model, created in Matlab-Simulink®, was integrated with a whole-body PBPK model, developed in PK-SIM 5.2®, to provide predictions of systemic drug disposition. SIWV within the CAT model was varied between 52.5mL and 420mL. Simulations incorporating specific SIWV values were compared to pharmacokinetic data from compounds exhibiting solubility induced non-proportional changes in absorption using absolute average fold-error. Correspondingly, data pertaining to oral administration of acyclovir and chlorothiazide were utilized to derive estimates of SIWV. At 400mg, a SIWV of 116mL provided the best estimates of acyclovir plasma concentrations. A similar SIWV was found to best depict the urinary excretion pattern of chlorothiazide at a dose of 100mg. In comparison, experimentally-based estimates of SIWV within adults denote a central tendency between 86 and 167mL. The derived SIWV (116mL) represents the optimal parameter value within the context of the developed CAT model. This result demonstrates the biological basis of the widely utilized CAT model as in vivo SIWV determinations correspond with model-based estimates.

  11. A small group learning model for evidence-based medicine

    Directory of Open Access Journals (Sweden)

    Al Achkar M

    2016-10-01

    Full Text Available Morhaf Al Achkar, M Kelly Davies Department of Family Medicine, Indiana University School of Medicine, Indianapolis, IN, USA Background: Evidence-based medicine (EBM skills are invaluable tools for residents and practicing physicians. The purpose of this study is to evaluate the effectiveness of small-group learning models in teaching fundamental EBM skills. Methods: The intervention consisted of an EBM bootcamp divided into four 2-hour sessions across 4-week rotations. Residents worked in small groups of three to four to explore fundamentals of EBM through interactive dialogue and mock clinical scenario practice. The intervention’s effectiveness was evaluated using pre- and post-assessments. Results: A total of 40 (93.0% residents out of a potential 43 participated in the EBM bootcamps across the 3 years. There was significant improvement of 3.28 points on self-assessed EBM skills from an average of 9.66–12.945 out of a maximum score of 15 (P=0.000. There was significant improvement of 1.68 points on the EBM skills test from an average of 6.02–7.71 out of a maximum score of 9 (P=0.00. All residents (100% agreed or strongly agreed that EBM is important for a physician’s clinical practice. This view did not change after the training. Conclusion: A brief small-group interactive workshop in EBM basic skills at the start of residency was effective in developing fundamental EBM skills. Keywords: evidence-based medicine, resident training, small group

  12. The Personal Virtual Library

    CERN Document Server

    Le Meur, Jean-Yves

    1998-01-01

    Looking for "library" in the usual search engines of the World Wide Web gives: "Infoseek found 3,593,126 pages containing the word library" and it nicely proposes: "Search only within these 3,59 3,126 pages ?" "Yahoo! Found 1299 categories and 8669 sites for library" "LycOs: 1-10 von 512354 relevanten Ergebnissen" "AltaVista: About 14830527 documents match your query" and at the botto m: "Word count: library: 15466897" ! Excite: Top 10 matches and it does not say how many can be browsed... "Library" on the World Wide Web is really popular. At least fiveteen million pages ar e supposed to contain this word. Half of them may have disappeared by now but one more hit will be added once the search robots will have indexed this document ! The notion of Personal Library i s a modest attempt, in a small environment like a library, to give poor users lost in cyber-libraries the opportunity to keep their own private little shelves - virtually. In this paper, we will l ook at the usual functionalities of library systems...

  13. Computer-aided pulmonary image analysis in small animal models

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Ziyue; Mansoor, Awais; Mollura, Daniel J. [Center for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda, Maryland 32892 (United States); Bagci, Ulas, E-mail: ulasbagci@gmail.com [Center for Research in Computer Vision (CRCV), University of Central Florida (UCF), Orlando, Florida 32816 (United States); Kramer-Marek, Gabriela [The Institute of Cancer Research, London SW7 3RP (United Kingdom); Luna, Brian [Microfluidic Laboratory Automation, University of California-Irvine, Irvine, California 92697-2715 (United States); Kubler, Andre [Department of Medicine, Imperial College London, London SW7 2AZ (United Kingdom); Dey, Bappaditya; Jain, Sanjay [Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 (United States); Foster, Brent [Department of Biomedical Engineering, University of California-Davis, Davis, California 95817 (United States); Papadakis, Georgios Z. [Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda, Maryland 32892 (United States); Camp, Jeremy V. [Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky 40202 (United States); Jonsson, Colleen B. [National Institute for Mathematical and Biological Synthesis, University of Tennessee, Knoxville, Tennessee 37996 (United States); Bishai, William R. [Howard Hughes Medical Institute, Chevy Chase, Maryland 20815 and Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 (United States); Udupa, Jayaram K. [Medical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States)

    2015-07-15

    Purpose: To develop an automated pulmonary image analysis framework for infectious lung diseases in small animal models. Methods: The authors describe a novel pathological lung and airway segmentation method for small animals. The proposed framework includes identification of abnormal imaging patterns pertaining to infectious lung diseases. First, the authors’ system estimates an expected lung volume by utilizing a regression function between total lung capacity and approximated rib cage volume. A significant difference between the expected lung volume and the initial lung segmentation indicates the presence of severe pathology, and invokes a machine learning based abnormal imaging pattern detection system next. The final stage of the proposed framework is the automatic extraction of airway tree for which new affinity relationships within the fuzzy connectedness image segmentation framework are proposed by combining Hessian and gray-scale morphological reconstruction filters. Results: 133 CT scans were collected from four different studies encompassing a wide spectrum of pulmonary abnormalities pertaining to two commonly used small animal models (ferret and rabbit). Sensitivity and specificity were greater than 90% for pathological lung segmentation (average dice similarity coefficient > 0.9). While qualitative visual assessments of airway tree extraction were performed by the participating expert radiologists, for quantitative evaluation the authors validated the proposed airway extraction method by using publicly available EXACT’09 data set. Conclusions: The authors developed a comprehensive computer-aided pulmonary image analysis framework for preclinical research applications. The proposed framework consists of automatic pathological lung segmentation and accurate airway tree extraction. The framework has high sensitivity and specificity; therefore, it can contribute advances in preclinical research in pulmonary diseases.

  14. Design and modeling of small scale multiple fracturing experiments

    Energy Technology Data Exchange (ETDEWEB)

    Cuderman, J F

    1981-12-01

    Recent experiments at the Nevada Test Site (NTS) have demonstrated the existence of three distinct fracture regimes. Depending on the pressure rise time in a borehole, one can obtain hydraulic, multiple, or explosive fracturing behavior. The use of propellants rather than explosives in tamped boreholes permits tailoring of the pressure risetime over a wide range since propellants having a wide range of burn rates are available. This technique of using the combustion gases from a full bore propellant charge to produce controlled borehole pressurization is termed High Energy Gas Fracturing (HEGF). Several series of HEGF, in 0.15 m and 0.2 m diameter boreholes at 12 m depths, have been completed in a tunnel complex at NTS where mineback permitted direct observation of fracturing obtained. Because such large experiments are costly and time consuming, smaller scale experiments are desirable, provided results from small experiments can be used to predict fracture behavior in larger boreholes. In order to design small scale gas fracture experiments, the available data from previous HEGF experiments were carefully reviewed, analytical elastic wave modeling was initiated, and semi-empirical modeling was conducted which combined predictions for statically pressurized boreholes with experimental data. The results of these efforts include (1) the definition of what constitutes small scale experiments for emplacement in a tunnel complex at the Nevada Test Site, (2) prediction of average crack radius, in ash fall tuff, as a function of borehole size and energy input per unit length, (3) definition of multiple-hydraulic and multiple-explosive fracture boundaries as a function of boreholes size and surface wave velocity, (4) semi-empirical criteria for estimating stress and acceleration, and (5) a proposal that multiple fracture orientations may be governed by in situ stresses.

  15. Comparing interval estimates for small sample ordinal CFA models.

    Science.gov (United States)

    Natesan, Prathiba

    2015-01-01

    Robust maximum likelihood (RML) and asymptotically generalized least squares (AGLS) methods have been recommended for fitting ordinal structural equation models. Studies show that some of these methods underestimate standard errors. However, these studies have not investigated the coverage and bias of interval estimates. An estimate with a reasonable standard error could still be severely biased. This can only be known by systematically investigating the interval estimates. The present study compares Bayesian, RML, and AGLS interval estimates of factor correlations in ordinal confirmatory factor analysis models (CFA) for small sample data. Six sample sizes, 3 factor correlations, and 2 factor score distributions (multivariate normal and multivariate mildly skewed) were studied. Two Bayesian prior specifications, informative and relatively less informative were studied. Undercoverage of confidence intervals and underestimation of standard errors was common in non-Bayesian methods. Underestimated standard errors may lead to inflated Type-I error rates. Non-Bayesian intervals were more positive biased than negatively biased, that is, most intervals that did not contain the true value were greater than the true value. Some non-Bayesian methods had non-converging and inadmissible solutions for small samples and non-normal data. Bayesian empirical standard error estimates for informative and relatively less informative priors were closer to the average standard errors of the estimates. The coverage of Bayesian credibility intervals was closer to what was expected with overcoverage in a few cases. Although some Bayesian credibility intervals were wider, they reflected the nature of statistical uncertainty that comes with the data (e.g., small sample). Bayesian point estimates were also more accurate than non-Bayesian estimates. The results illustrate the importance of analyzing coverage and bias of interval estimates, and how ignoring interval estimates can be misleading

  16. Modelling and Model-Based-Designed PID Control of the JT-60SA Cryogenic System Using the Simcryogenics Library

    Science.gov (United States)

    Bonne, F.; Bonnay, P.; Hoa, C.; Mahoudeau, G.; Rousset, B.

    2017-02-01

    This papers deals with the Japan Torus-60 Super Advanced fusion experiment JT-60SA cryogenic system. A presentation of the JT-60SA cryogenic system model, from 300K to 4.4K -using the Matlab/Simulink/Simscape Simcryogenics library- will be given. As a first validation of our modelling strategy, the obtained operating point will be compared with the one obtained from HYSYS simulations. In the JT60-SA tokamak, pulsed heat loads are expected to be coming from the plasma and must be handled properly, using both appropriate refrigerator architecture and appropriate control model, to smooth the heat load. This paper presents model-based designed PID control schemes to control the helium mass inside the phase separator. The helium mass inside the phase separator as been chosen to be the variable of interest in the phase separator since it is independent of the pressure which can vary from 1 bar to 1.8 bar during load smoothing. Dynamics simulations will be shown to assess the legitimacy of the proposed strategy. This work is partially supported through the French National Research Agency (ANR), task agreement ANR-13-SEED-0005.

  17. Experience in Computer-Assisted XML-Based Modelling in the Context of Libraries

    CERN Document Server

    Niinimäki, M

    2003-01-01

    In this paper, we introduce a software called Meta Data Visualisation (MDV) that (i) assists the user with a graphical user interface in the creation of his specific document types, (ii) creates a database according to these document types, (iii) allows the user to browse the database, and (iv) uses native XML presentation of the data in order to allow queries or data to be exported to other XML-based systems. We illustrate the use of MDV and XML modelling using library-related examples to build a bibliographic database. In our opinion, creating document type descriptions corresponds to conceptual and logical database design in a database design process. We consider that this design can be supported with a suitable set of tools that help the designer concentrate on conceptual issues instead of implementation issues. Our hypothesis is that using the methodology presented in this paper we can create XML databases that are useful and relevant, and with which MDV works as a user interface.

  18. 15种氨基酸随机肽库的小盒式DNA编码文库的构建%Construction of a DNA Library in Small Cassette Encoding Random Peptide Consisting of 15 Amino Acids

    Institute of Scientific and Technical Information of China (English)

    卢明锋; 康寿凯; 张月杰; 张红雨

    2012-01-01

    采用小盒式DNA编码文库的构建策略,选取在进化上可能起源较早的15种氨基酸,按照其简并密码子合成了一个为10个随机氨基酸编码的小盒式DNA模板,经过连续3轮的PCR扩增、酶切及连接的小盒式文库组装过程,成功构建了一个文库容量达1.31×1012/ml,随机编码区长达97个氨基酸的小盒式DNA编码文库.%Using a small cassette DNA encoding library construction strategies, DNA template encoding 10 random amino acids was synthesized according to degenerate codon of a 15 kinds amino acids set. After three consecutive small cassette library assembly process including PCR amplification, digestion and connection, a small cassette DNA encoding library which a random coding region with length up to 97 amino acids was successfully constructed, and library capacity was 1.31×1012 /ml.

  19. High resolution modeling of a small urban catchment

    Science.gov (United States)

    Skouri-Plakali, Ilektra; Ichiba, Abdellah; Gires, Auguste; Tchiguirinskaia, Ioulia; Schertzer, Daniel

    2016-04-01

    Flooding is one of the most complex issues that urban environments have to deal with. In France, flooding remains the first natural risk with 72% of decrees state of natural disaster issued between October 1982 and mid-November 2014. Flooding is a result of meteorological extremes that are usually aggravated by the hydrological behavior of urban catchments and human factors. The continuing urbanization process is indeed changing the whole urban water cycle by limiting the infiltration and promoting runoff. Urban environments are very complex systems due to their extreme variability, the interference between human activities and natural processes but also the effect of the ongoing urbanization process that changes the landscape and hardly influences their hydrologic behavior. Moreover, many recent works highlight the need to simulate all urban water processes at their specific temporal and spatial scales. However, considering urban catchments heterogeneity still challenging for urban hydrology, even after advances noticed in term of high-resolution data collection and computational resources. This issue is more to be related to the architecture of urban models being used and how far these models are ready to take into account the extreme variability of urban catchments. In this work, high spatio-temporal resolution modeling is performed for a small and well-equipped urban catchment. The aim of this work is to identify urban modeling needs in terms of spatial and temporal resolution especially for a very small urban area (3.7 ha urban catchment located in the Perreux-sur-Marne city at the southeast of Paris) MultiHydro model was selected to carry out this work, it is a physical based and fully distributed model that interacts four existing modules each of them representing a portion of the water cycle in urban environments. MultiHydro was implemented at 10m, 5m and 2m resolution. Simulations were performed at different spatio-temporal resolutions and analyzed with

  20. A Scalable Cloud Library Empowering Big Data Management, Diagnosis, and Visualization of Cloud-Resolving Models

    Science.gov (United States)

    Zhou, S.; Tao, W. K.; Li, X.; Matsui, T.; Sun, X. H.; Yang, X.

    2015-12-01

    A cloud-resolving model (CRM) is an atmospheric numerical model that can numerically resolve clouds and cloud systems at 0.25~5km horizontal grid spacings. The main advantage of the CRM is that it can allow explicit interactive processes between microphysics, radiation, turbulence, surface, and aerosols without subgrid cloud fraction, overlapping and convective parameterization. Because of their fine resolution and complex physical processes, it is challenging for the CRM community to i) visualize/inter-compare CRM simulations, ii) diagnose key processes for cloud-precipitation formation and intensity, and iii) evaluate against NASA's field campaign data and L1/L2 satellite data products due to large data volume (~10TB) and complexity of CRM's physical processes. We have been building the Super Cloud Library (SCL) upon a Hadoop framework, capable of CRM database management, distribution, visualization, subsetting, and evaluation in a scalable way. The current SCL capability includes (1) A SCL data model enables various CRM simulation outputs in NetCDF, including the NASA-Unified Weather Research and Forecasting (NU-WRF) and Goddard Cumulus Ensemble (GCE) model, to be accessed and processed by Hadoop, (2) A parallel NetCDF-to-CSV converter supports NU-WRF and GCE model outputs, (3) A technique visualizes Hadoop-resident data with IDL, (4) A technique subsets Hadoop-resident data, compliant to the SCL data model, with HIVE or Impala via HUE's Web interface, (5) A prototype enables a Hadoop MapReduce application to dynamically access and process data residing in a parallel file system, PVFS2 or CephFS, where high performance computing (HPC) simulation outputs such as NU-WRF's and GCE's are located. We are testing Apache Spark to speed up SCL data processing and analysis.With the SCL capabilities, SCL users can conduct large-domain on-demand tasks without downloading voluminous CRM datasets and various observations from NASA Field Campaigns and Satellite data to a

  1. The Study of Analytical Model of Library Electronic Resources Usage-A Case of Medical Electronic Resources

    Directory of Open Access Journals (Sweden)

    Chung-Yen Yu

    2014-10-01

    Full Text Available With the advents of internet, the importance of electronic resources is growing. Due to the increasing expensiveness of electronic resources, university libraries normally received budgets from parent institutions annually. They necessarily applied effective and systematic methods for decision making in electronic resources purchase or re-subscription. However, there are some difficulties in practices: First of all, libraries are unable to receive user records; second, the COUNTER statistics does not include details about users and their affiliation. As a result, one cannot conduct advanced user analysis based on the usage of users, institutions, and departments. To overcome the difficulties, this study presents a feasible model to analyze electronic resource usage effectively and flexibly. We set up a proxy server to collect actual usage raw data. By analyzing items in internet browsing records, associated with original library automatic system, this study aims at exploring how to use effective ways to analyze big data of website log data. We also propose the process of how original data to be transformed, cleared, integrated, and demonstrated. This study adopted a medical university library and its subscription of medical electronic resources as a case. Our data analysis includes (1 year of subscription,(2 title of journal, (3 affiliation, (4 subjects, and (5 specific journal requirements, etc. The findings of the study are contributed to obtain further understanding in policy making and user behavior analysis. The integrated data provides multiple applications in informatics research, information behavior, bibliomining, presenting diverse views and extended issues for further discussion.

  2. Soybean yield modeling using bootstrap methods for small samples

    Energy Technology Data Exchange (ETDEWEB)

    Dalposso, G.A.; Uribe-Opazo, M.A.; Johann, J.A.

    2016-11-01

    One of the problems that occur when working with regression models is regarding the sample size; once the statistical methods used in inferential analyzes are asymptotic if the sample is small the analysis may be compromised because the estimates will be biased. An alternative is to use the bootstrap methodology, which in its non-parametric version does not need to guess or know the probability distribution that generated the original sample. In this work we used a set of soybean yield data and physical and chemical soil properties formed with fewer samples to determine a multiple linear regression model. Bootstrap methods were used for variable selection, identification of influential points and for determination of confidence intervals of the model parameters. The results showed that the bootstrap methods enabled us to select the physical and chemical soil properties, which were significant in the construction of the soybean yield regression model, construct the confidence intervals of the parameters and identify the points that had great influence on the estimated parameters. (Author)

  3. Digestion of starch in a dynamic small intestinal model.

    Science.gov (United States)

    Jaime-Fonseca, M R; Gouseti, O; Fryer, P J; Wickham, M S J; Bakalis, S

    2016-12-01

    The rate and extent of starch digestion have been linked with important health aspects, such as control of obesity and type-2 diabetes. In vitro techniques are often used to study digestion and simulated nutrient absorption; however, the effect of gut motility is often disregarded. The present work aims at studying fundamentals of starch digestion, e.g. the effect of viscosity on digestibility, taking into account both biochemical and engineering (gut motility) parameters. New small intestinal model (SIM) that realistically mimics gut motility (segmentation) was used to study digestibility and simulated oligosaccharide bio accessibility of (a) model starch solutions; (b) bread formulations. First, the model was compared with the rigorously mixed stirred tank reactor (STR). Then the effects of enzyme concentration/flow rate, starch concentration, and digesta viscosity (addition of guar gum) were evaluated. Compared to the STR, the SIM showed presence of lag phase when no digestive processes could be detected. The effects of enzyme concentration and flow rate appeared to be marginal in the region of mass transfer limited reactions. Addition of guar gum reduced simulated glucose absorption by up to 45 % in model starch solutions and by 35 % in bread formulations, indicating the importance of chyme rheology on nutrient bioaccessibility. Overall, the work highlights the significance of gut motility in digestive processes and offers a powerful tool in nutritional studies that, additionally to biochemical, considers engineering aspects of digestion. The potential to modulate food digestibility and nutrient bioaccessibility by altering food formulation is indicated.

  4. Small World Model-Based Polylogarithmic Routing Using Mobile Nodes

    Institute of Scientific and Technical Information of China (English)

    Jie Wu; Shu-Hui Yang

    2008-01-01

    The use of mobile nodes to improve network system performance has drawn considerable attention recently.The movement-assisted model considers mobility as a desirable feature, where routing is based on the store-carry-forward paradigm with random or controlled movement of resource rich mobile nodes. The application of such a model has been used in several emerging networks, including mobile ad hoc networks (MANETs), wireless sensor networks (WSNs), and delay tolerant networks (DTNs). It is well known that mobility increases the capacity of MANETs by reducing the number of relays for routing, prolonging the lifespan of WSNs by using mobile nodes in place of bottleneck static sensors, and ensuring network connectivity in DTNs using mobile nodes to connect different parts of a disconnected network. Trajectory planning and the coordination of mobile nodes are two important design issues aiming to optimize or balance several measures,including delay, average number of relays, and moving distance. In this paper, we propose a new controlled mobility model with an expected polylogarithmic number of relays to achieve a good balance among several contradictory goals, including delay, the number of relays, and moving distance. The model is based on the small-world model where each static node has "short" link connections to its nearest neighbors and "long" link connections to other nodes following a certain probability distribution. Short links are regular wireless connections whereas long links are implemented using mobile nodes. Various issues are considered, including trade-offs between delay and average number of relays, selection of the number of mobilenodes, and selection of the number of long links. The effectiveness of the proposed model is evaluated analytically as well as through simulation.

  5. Flexible modeling frameworks to replace small ensembles of hydrological models and move toward large ensembles?

    Science.gov (United States)

    Addor, Nans; Clark, Martyn P.; Mizukami, Naoki

    2017-04-01

    Climate change impacts on hydrological processes are typically assessed using small ensembles of hydrological models. That is, a handful of hydrological models are typically driven by a larger number of climate models. Such a setup has several limitations. Because the number of hydrological models is small, only a small proportion of the model space is sampled, likely leading to an underestimation of the uncertainties in the projections. Further, sampling is arbitrary: although hydrological models should be selected to provide a representative sample of existing models (in terms of complexity and governing hypotheses), they are instead usually selected based on legacy reasons. Furthermore, running several hydrological models currently constitutes a practical challenge because each model must be setup and calibrated individually. Finally, and probably most importantly, the differences between the projected impacts cannot be directly related to differences between hydrological models, because the models are different in almost every possible aspect. We are hence in a situation in which different hydrological models deliver different projections, but for reasons that are mostly unclear, and in which the uncertainty in the projections is probably underestimated. To overcome these limitations, we are experimenting with the flexible modeling framework FUSE (Framework for Understanding Model Errors). FUSE enables to construct conceptual models piece by piece (in a "pick and mix" approach), so it can be used to generate a large number of models that mimic existing models and/or models that differ from other models in single targeted respect (e.g. how baseflow is generated). FUSE hence allows for controlled modeling experiments, and for a more systematic and exhaustive sampling of the model space. Here we explore climate change impacts over the contiguous USA on a 12km grid using two groups of three models: the first group involves the commonly used models VIC, PRMS and HEC

  6. Update on Small Modular Reactors Dynamic System Modeling Tool: Web Application

    Energy Technology Data Exchange (ETDEWEB)

    Hale, Richard Edward [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Cetiner, Sacit M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Fugate, David L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Batteh, John J [Modelon Corporation (Sweden); Tiller, Michael M. [Xogeny Corporation (United States)

    2015-01-01

    Previous reports focused on the development of component and system models as well as end-to-end system models using Modelica and Dymola for two advanced reactor architectures: (1) Advanced Liquid Metal Reactor and (2) fluoride high-temperature reactor (FHR). The focus of this report is the release of the first beta version of the web-based application for model use and collaboration, as well as an update on the FHR model. The web-based application allows novice users to configure end-to-end system models from preconfigured choices to investigate the instrumentation and controls implications of these designs and allows for the collaborative development of individual component models that can be benchmarked against test systems for potential inclusion in the model library. A description of this application is provided along with examples of its use and a listing and discussion of all the models that currently exist in the library.

  7. Small Area Model-Based Estimators Using Big Data Sources

    Directory of Open Access Journals (Sweden)

    Marchetti Stefano

    2015-06-01

    Full Text Available The timely, accurate monitoring of social indicators, such as poverty or inequality, on a finegrained spatial and temporal scale is a crucial tool for understanding social phenomena and policymaking, but poses a great challenge to official statistics. This article argues that an interdisciplinary approach, combining the body of statistical research in small area estimation with the body of research in social data mining based on Big Data, can provide novel means to tackle this problem successfully. Big Data derived from the digital crumbs that humans leave behind in their daily activities are in fact providing ever more accurate proxies of social life. Social data mining from these data, coupled with advanced model-based techniques for fine-grained estimates, have the potential to provide a novel microscope through which to view and understand social complexity. This article suggests three ways to use Big Data together with small area estimation techniques, and shows how Big Data has the potential to mirror aspects of well-being and other socioeconomic phenomena.

  8. Electron Transport through Models for Small-World Nanomaterials

    Science.gov (United States)

    Solomon, Lazarus; Novotny, Mark

    2008-03-01

    We investigate the quantum transport of (spinless) electrons through simplified models related to small-world nanomaterials. We employ a tight-binding Hamiltonian, and obtain the transmission coefficient from a matrix solution of the associated time-independent Schrödinger Equation. The system studied corresponds to d=1 semi-infinite input and output leads, connected to a `blob' of N atoms. We first present exact results for N inter-connected atoms, a fully-connected graph. The exact solution, for any N, is given both for symmetric and non-symmetric connections between the `blob' and the input/output. We then present numerical results obtained by removing some of the connections within the N-site `blob', thereby approaching transport through a small-world nanomaterial [1-4]. [1] S. Caliskan, M.A. Novotny, and J.I. Cerd'a, J. Appl. Phys., 102, 013707 (2007). [2] M.A. Novotny et al., J. Appl. Phys., 97, 10B309 (2005). [3] M.A. Novotny and S.M. Wheeler, Braz. J. Physics 34, 395 (2004). [4] J. Yancey, M.A. Novotny, and S.R. Gwaltney, 2008 March Meeting presentation.

  9. Simple Electromagnetic Modeling of Small Airplanes: Neural Network Approach

    Directory of Open Access Journals (Sweden)

    P. Tobola

    2009-04-01

    Full Text Available The paper deals with the development of simple electromagnetic models of small airplanes, which can contain composite materials in their construction. Electromagnetic waves can penetrate through the surface of the aircraft due to the specific electromagnetic properties of the composite materials, which can increase the intensity of fields inside the airplane and can negatively influence the functionality of the sensitive avionics. The airplane is simulated by two parallel dielectric layers (the left-hand side wall and the right-hand side wall of the airplane. The layers are put into a rectangular metallic waveguide terminated by the absorber in order to simulate the illumination of the airplane by the external wave (both of the harmonic nature and pulse one. Thanks to the simplicity of the model, the parametric analysis can be performed, and the results can be used in order to train an artificial neural network. The trained networks excel in further reduction of CPU-time demands of an airplane modeling.

  10. ICT evaluation models and performance of medium and small enterprises

    Directory of Open Access Journals (Sweden)

    Bayaga Anass

    2014-01-01

    Full Text Available Building on prior research related to (1 impact of information communication technology (ICT and (2 operational risk management (ORM in the context of medium and small enterprises (MSEs, the focus of this study was to investigate the relationship between (1 ICT operational risk management (ORM and (2 performances of MSEs. To achieve the focus, the research investigated evaluating models for understanding the value of ICT ORM in MSEs. Multiple regression, Repeated-Measures Analysis of Variance (RM-ANOVA and Repeated-Measures Multivariate Analysis of Variance (RM-MANOVA were performed. The findings of the distribution revealed that only one variable made a significant percentage contribution to the level of ICT operation in MSEs, the Payback method (β = 0.410, p < .000. It may thus be inferred that the Payback method is the prominent variable, explaining the variation in level of evaluation models affecting ICT adoption within MSEs. Conclusively, in answering the two questions (1 degree of variability explained and (2 predictors, the results revealed that the variable contributed approximately 88.4% of the variations in evaluation models affecting ICT adoption within MSEs. The analysis of variance also revealed that the regression coefficients were real and did not occur by chance

  11. Small-scale behaviour in deterministic reaction models

    Energy Technology Data Exchange (ETDEWEB)

    Politi, Paolo [Istituto dei Sistemi Complessi, Consiglio Nazionale delle Ricerche, Via Madonna del Piano 10, 50019 Sesto Fiorentino (Italy); Ben-Avraham, Daniel, E-mail: paolo.politi@isc.cnr.i, E-mail: benavraham@clarkson.ed [Physics Department, Clarkson University, Potsdam, NY 13699-5820 (United States)

    2010-10-08

    In a recent paper published in this journal (2009 J. Phys. A: Math. Theor. 42 495004) we studied a one-dimensional particles system where nearest particles attract with a force inversely proportional to a power {alpha} of their distance and coalesce upon encounter. Numerics yielded a distribution function h(z) for the gap between neighbouring particles, with h(z) {approx} z{sup {beta}({alpha})} for small z and {beta}({alpha}) > {alpha}. We can now prove analytically that in the strict limit of z {yields} 0, {beta} = {alpha} for {alpha} > 0, corresponding to the mean-field result, and we compute the length scale where the mean field breaks down. More generally, in that same limit correlations are negligible for any similar reaction model where attractive forces diverge with vanishing distance. The actual meaning of the measured exponent {beta}({alpha}) remains an open question.

  12. Two agricultural production data libraries for risk assessment models. [Ovis aries; Capra hircus; Sus scrofa; Gallus domesticus; Meleagris gallopavo

    Energy Technology Data Exchange (ETDEWEB)

    Baes, C.F. III; Shor, R.W.; Sharp, R.D.; Sjoreen, A.L.

    1985-01-01

    Two data libraries based on the 1974 US Census of Agriculture are described. The data packages (AGDATC and AGDATG) are available from the Radiation Shielding Information Center (RSIC), Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831. Agricultural production and land-use information by county (AGDATC) or by 1/2 by 1/2 degree longitude-latitude grid cell (AGDATG) provide geographical resolution of the data. The libraries were designed for use in risk assessment models that simulate the transport of radionuclides from sources of airborne release through food chains to man. However, they are also suitable for use in the assessment of other airborne pollutants that can affect man from a food ingestion pathway such as effluents from synfuels or coal-fired power plants. The principal significance of the data libraries is that they provide default location-specific food-chain transport parameters when site-specific information are unavailable. Plant food categories in the data libraries include leafy vegetables, vegetables and fruits exposed to direct deposition of airborne pollutants, vegetables and fruits protected from direct deposition, and grains. Livestock feeds are also tabulated in four categories: pasture, grain, hay, and silage. Pasture was estimated by a material balance of cattle and sheep inventories, forage feed requirements, and reported harvested forage. Cattle (Bos spp.), sheep (Ovis aries), goat (Capra hircus), hog (Sus scrofa), chicken (Gallus domesticus), and turkey (Meleagris gallopavo) inventories or sales are also tabulated in the data libraries and can be used to provide estimates of meat, eggs, and milk production. Honey production also is given. Population, irrigation, and meteorological information are also listed.

  13. In Vitro Sensitivity Profiling Of Neuroblastoma Cells Against A Comprehensive Small Molecule Kinase Inhibitor Library To Identify Agents For Future Therapeutic Studies.

    Science.gov (United States)

    Singh, Anjali; Meier-Stephenson, Vanessa; Jayanthan, Aarthi; Narendran, Aru

    2016-11-22

    Solid tumors represent one of the most widespread causes of death in children across the world. Neuroblastoma (NB) constitutes about 8% of all childhood tumors, yet accounts for more than 15% of death, with an unacceptable overall survival rate. Despite the current multimodal therapeutic approaches involving surgery, radiation, chemotherapy with myeloablative therapy and hematopoietic stem cell rescue, there is growing realization of the limitations of conventional agents to improve the outcome in high risk metastatic disease. Hence, efforts have intensified to identify new targets and novel therapeutic approaches to improve cure rates in these children. Among the significant number of new therapeutics that are being evaluated for cancer each year, the agents that have been developed for common adult malignancies have the added advantage of having usable toxicity data already available for consideration. To identify potential therapeutic targets, we screened a small molecule library of 151 small kinase inhibitors against NB cell lines. Based on our initial screening data, we further examined the potential of Bcr-Abl targeting small molecule inhibitors to affect the growth and survival of NB cells. Our findings confirm the diversity in activity among the currently available Bcr-Abl inhibitors, possibly reflecting the molecular heterogeneity and off-target activity in each combination. In depth analyses of ponatinib, an orally bioavailable multi-target kinase inhibitor and an effective agent in the treatment of refractory Philadelphia chromosome (Ph) positive leukemia, show growth inhibition at sub-micromolar concentrations. In addition, we also identified the potential of this agent to interfere with insulin-like growth factor-1 receptor (IGF-1R) signaling pathways and Src activity. Ponatinib also induced apoptosis, indicated by caspase-9 and PARP cleavage. Furthermore, at sub-lethal conditions ponatinib significantly inhibited the ability of these cells to migrate

  14. Bayesian model comparison and model averaging for small-area estimation

    OpenAIRE

    Aitkin, Murray; Liu, Charles C.; Chadwick, Tom

    2009-01-01

    This paper considers small-area estimation with lung cancer mortality data, and discusses the choice of upper-level model for the variation over areas. Inference about the random effects for the areas may depend strongly on the choice of this model, but this choice is not a straightforward matter. We give a general methodology for both evaluating the data evidence for different models and averaging over plausible models to give robust area effect distributions. We reanalyze the data of Tsutak...

  15. SIMPLIFIED MATHEMATICAL MODEL OF SMALL SIZED UNMANNED AIRCRAFT VEHICLE LAYOUT

    Directory of Open Access Journals (Sweden)

    2016-01-01

    Full Text Available Strong reduction of new aircraft design period using new technology based on artificial intelligence is the key problem mentioned in forecasts of leading aerospace industry research centers. This article covers the approach to devel- opment of quick aerodynamic design methods based on artificial intelligence neural system. The problem is being solved for the classical scheme of small sized unmanned aircraft vehicle (UAV. The principal parts of the method are the mathe- matical model of layout, layout generator of this type of aircraft is built on aircraft neural networks, automatic selection module for cleaning variety of layouts generated in automatic mode, robust direct computational fluid dynamics method, aerodynamic characteristics approximators on artificial neural networks.Methods based on artificial neural networks have intermediate position between computational fluid dynamics methods or experiments and simplified engineering approaches. The use of ANN for estimating aerodynamic characteris-tics put limitations on input data. For this task the layout must be presented as a vector with dimension not exceeding sev-eral hundred. Vector components must include all main parameters conventionally used for layouts description and com- pletely replicate the most important aerodynamics and structural properties.The first stage of the work is presented in the paper. Simplified mathematical model of small sized UAV was developed. To estimate the range of geometrical parameters of layouts the review of existing vehicle was done. The result of the work is the algorithm and computer software for generating the layouts based on ANN technolo-gy. 10000 samples were generated and the dataset containig geometrical and aerodynamic characteristics of layoutwas created.

  16. RecA-assisted rapid enrichment of specific clones from model DNA libraries.

    Science.gov (United States)

    Teintze, M; Arzimanoglou, I I; Lovelace, C I; Xu, Z J; Rigas, B

    1995-06-26

    An approach to library screening is being developed, in which the desired clone is "fished" out of a mixture of all the recombinants in a library with a RecA-coated probe. In the current embodiment of this method, we used as a probe the (+) strand of an M13 phage containing a fragment of the human albumin gene and a (dA)49 stretch. We screened a library of two plasmids, one containing the same albumin fragment as the probe, and one heterologous to the probe in 50-100 fold molar excess. The plasmids were linearized. Probe and library were reacted in the presence of RecA, the mixture was loaded onto an oligo(dT) column, which retained the probe-target complex by base-pairing to the dAs of the probe, the uncaptured plasmids were washed, and the probe-target complex was released from the column, religated and propagated into E. coli. Recovery of the homologous target was 15-28%, and enrichment for the homologous plasmid was 200 to 400-fold. This approach may provide a general method for expedited DNA library screening.

  17. Modelling transition states of a small once-through boiler

    Energy Technology Data Exchange (ETDEWEB)

    Talonpoika, T. [Lappeenranta Univ. of Technology (Finland). Dept. of Energy Technology

    1997-12-31

    the model gives results that are logical in the directions of the charges, and the order of magnitude of the time scale of charges is also as expected. The results of the tests on the process fluid side show that the model gives reasonable results both on temperature charges that cause small alterations in the process state and on mass flow rate charges causing very great alterations. The test runs show that the dynamic model has no problems in calculating cases in which the temperature of the entering heat source suddenly goes below that of the tube wall or the process fluid. (author) 7 refs.

  18. Modelling hourly rates of evaporation from small lakes

    Directory of Open Access Journals (Sweden)

    R. J. Granger

    2011-01-01

    Full Text Available The paper presents the results of a field study of open water evaporation carried out on three small lakes in Western and Northern Canada. In this case small lakes are defined as those for which the temperature above the water surface is governed by the upwind land surface conditions; that is, a continuous boundary layer exists over the lake, and large-scale atmospheric effects such as entrainment do not come into play. Lake evaporation was measured directly using eddy covariance equipment; profiles of wind speed, air temperature and humidity were also obtained over the water surfaces. Observations were made as well over the upwind land surface.

    The major factors controlling open water evaporation were examined. The study showed that for time periods shorter than daily, the open water evaporation bears no relationship to the net radiation; the wind speed is the most significant factor governing the evaporation rates, followed by the land-water temperature contrast and the land-water vapour pressure contrast. The effect of the stability on the wind field was demonstrated; relationships were developed relating the land-water wind speed contrast to the land-water temperature contrast. The open water period can be separated into two distinct evaporative regimes: the warming period in the Spring, when the land is warmer than the water, the turbulent fluxes over water are suppressed; and the cooling period, when the water is warmer than the land, the turbulent fluxes over water are enhanced.

    Relationships were developed between the hourly rates of lake evaporation and the following significant variables and parameters (wind speed, land-lake temperature and humidity contrasts, and the downwind distance from shore. The result is a relatively simple versatile model for estimating the hourly lake evaporation rates. The model was tested using two independent data sets. Results show that the modelled evaporation follows the observed values

  19. A method for using solid modeling CAD software to create an implant library for the fabrication of a custom abutment.

    Science.gov (United States)

    Zhang, Jing; Zhang, Rimei; Ren, Guanghui; Zhang, Xiaojie

    2017-02-01

    This article describes a method that incorporates the solid modeling CAD software Solidworks with a dental milling machine to fabricate individual abutments in house. This process involves creating an implant library with 3-dimensional (3D) models and manufacturing a base, scan element, abutment, and crown anatomy. The 3D models can be imported into any dental computer-aided design and computer-aided (CAD-CAM) manufacturing system. This platform increases abutment design flexibility, as the base and scan elements can be designed to fit several shapes as needed to meet clinical requirements. Copyright © 2016 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

  20. The Data Model Resource Book A Library of Universal Data Models for All Enterprises

    CERN Document Server

    Silverston, Len

    2008-01-01

    A quick and reliable way to build proven databases for core business functionsIndustry experts raved about The Data Model Resource Book when it was first published in March 1997 because it provided a simple, cost-effective way to design databases for core business functions. Len Silverston has now revised and updated the hugely successful First Edition, while adding a companion volume to take care of more specific requirements of different businesses. Each volume is accompanied by a CD-ROM, which is sold separately. Each CD-ROM provides powerful design templates discussed in the books in a rea

  1. Community Digital Library Requirements for the Southern California Earthquake Center Community Modeling Environment (SCEC/CME)

    Science.gov (United States)

    Moore, R.; Faerman, M.; Minster, J.; Day, S. M.; Ely, G.

    2003-12-01

    A community digital library provides support for ingestion, organization, description, preservation, and access of digital entities. The technologies that traditionally provide these capabilities are digital libraries (ingestion, organization, description), persistent archives (preservation) and data grids (access). We present a design for the SCEC community digital library that incorporates aspects of all three systems. Multiple groups have created integrated environments that sustain large-scale scientific data collections. By examining these projects, the following stages of implementation can be identified: \\begin{itemize} Definition of semantic terms to associate with relevant information. This includes definition of uniform content descriptors to describe physical quantities relevant to the scientific discipline, and creation of concept spaces to define how the uniform content descriptors are logically related. Organization of digital entities into logical collections that make it simple to browse and manage related material. Definition of services that are used to access and manipulate material in the collection. Creation of a preservation environment for the long-term management of the collection. Each community is faced with heterogeneity that is introduced when data is distributed across multiple sites, or when multiple sets of collection semantics are used, and or when multiple scientific sub-disciplines are federated. We will present the relevant standards that simplify the implementation of the SCEC community library, the resource requirements for different types of data sets that drive the implementation, and the digital library processes that the SCEC community library will support. The SCEC community library can be viewed as the set of processing steps that are required to build the appropriate SCEC reference data sets (SCEC approved encoding format, SCEC approved descriptive metadata, SCEC approved collection organization, and SCEC managed storage

  2. Library Computing

    Science.gov (United States)

    Library Computing, 1985

    1985-01-01

    Special supplement to "Library Journal" and "School Library Journal" covers topics of interest to school, public, academic, and special libraries planning for automation: microcomputer use, readings in automation, online searching, databases of microcomputer software, public access to microcomputers, circulation, creating a…

  3. Digital Libraries

    CERN Document Server

    Papy, Fabrice

    2008-01-01

    Of vital interest to all librarians and information specialists, this book presents all aspects of the effects of digitization of today's and tomorrow's libraries. From social to technical issues, Digital Libraries includes chapters on the growth of the role of librarian, the reader experience, cataloging, search engines, OPAC, law, ergonomic studies, and the future of libraries.

  4. Biomedical Libraries

    Science.gov (United States)

    Pizer, Irwin H.

    1978-01-01

    Biomedical libraries are discussed as a distinct and specialized group of special libraries and their unique services and user interactions are described. The move toward professional standards, as evidenced by the Medical Library Association's new certification program, and the current state of development for a new section of IFLA established…

  5. Cell and small animal models for phenotypic drug discovery

    Directory of Open Access Journals (Sweden)

    Szabo M

    2017-06-01

    Full Text Available Mihaly Szabo,1 Sara Svensson Akusjärvi,1 Ankur Saxena,1 Jianping Liu,2 Gayathri Chandrasekar,1 Satish S Kitambi1 1Department of Microbiology Tumor, and Cell Biology, 2Department of Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden Abstract: The phenotype-based drug discovery (PDD approach is re-emerging as an alternative platform for drug discovery. This review provides an overview of the various model systems and technical advances in imaging and image analyses that strengthen the PDD platform. In PDD screens, compounds of therapeutic value are identified based on the phenotypic perturbations produced irrespective of target(s or mechanism of action. In this article, examples of phenotypic changes that can be detected and quantified with relative ease in a cell-based setup are discussed. In addition, a higher order of PDD screening setup using small animal models is also explored. As PDD screens integrate physiology and multiple signaling mechanisms during the screening process, the identified hits have higher biomedical applicability. Taken together, this review highlights the advantages gained by adopting a PDD approach in drug discovery. Such a PDD platform can complement target-based systems that are currently in practice to accelerate drug discovery. Keywords: phenotype, screening, PDD, discovery, zebrafish, drug

  6. Applying DEA Technique to Library Evaluation in Academic Research Libraries.

    Science.gov (United States)

    Shim, Wonsik

    2003-01-01

    This study applied an analytical technique called Data Envelopment Analysis (DEA) to calculate the relative technical efficiency of 95 academic research libraries, all members of the Association of Research Libraries. DEA, with the proper model of library inputs and outputs, can reveal best practices in the peer groups, as well as the technical…

  7. 图书馆文化塑造刍议%On the Modeling of the Library Culture

    Institute of Scientific and Technical Information of China (English)

    蒋向红

    2001-01-01

    图书馆文化塑造是一个循环往复,不断提高的过程,其步骤包括基 础调研、目标设计、指导实践、完善提高四个环节,而创立图书馆文化礼仪,塑造图书馆文化楷模,创造图书馆文化氛围是图书馆文化塑造的基本形式。%The modeling of the library culture is a spirally progressing proce dure,which includes four stages: survey, objective design,guidance of practice and improvement. Adopting acceptable protocols, establishing fit example s and creating good environments constitute the main contents of the library cult ure.

  8. A theoretical model to predict customer satisfaction in relation to service quality in selected university libraries in Sri Lanka

    Directory of Open Access Journals (Sweden)

    Chaminda Jayasundara

    2009-01-01

    Full Text Available University library administrators in Sri Lanka have begun to search for alternative ways to satisfy their clientele on the basis of service quality. This article aims at providing a theoretical model to facilitate the identification of service quality attributes and domains that may be used to predict customer satisfaction from a service quality perspective. The effectiveness of existing service quality models such as LibQUAL, SERVQUAL and SERVPREF have been questioned. In that regard, this study developed a theoretical model for academic libraries in Sri Lanka based on the disconfirmation and performance-only paradigms. These perspectives were considered by researchers to be the core mechanism to develop service quality/customer satisfaction models. The attributes and domain identification of service quality was carried out with a stratified sample of 263 participants selected from postgraduate and undergraduate students and academic staff members from the faculties of Arts in four universities in Sri Lanka. The study established that responsiveness, supportiveness, building environment, collection and access, furniture and facilities, technology, Web services and service delivery were quality domains which can be used to predict customer satisfaction. The theoretical model is unique in its domain structure compared to the existing models. The model needs to be statistically tested to make it valid and parsimonious.

  9. Computational model for simulation small testing launcher, technical solution

    Energy Technology Data Exchange (ETDEWEB)

    Chelaru, Teodor-Viorel, E-mail: teodor.chelaru@upb.ro [University POLITEHNICA of Bucharest - Research Center for Aeronautics and Space, Str. Ghe Polizu, nr. 1, Bucharest, Sector 1 (Romania); Cristian, Barbu, E-mail: barbucr@mta.ro [Military Technical Academy, Romania, B-dul. George Coşbuc, nr. 81-83, Bucharest, Sector 5 (Romania); Chelaru, Adrian, E-mail: achelaru@incas.ro [INCAS -National Institute for Aerospace Research Elie Carafoli, B-dul Iuliu Maniu 220, 061126, Bucharest, Sector 6 (Romania)

    2014-12-10

    The purpose of this paper is to present some aspects regarding the computational model and technical solutions for multistage suborbital launcher for testing (SLT) used to test spatial equipment and scientific measurements. The computational model consists in numerical simulation of SLT evolution for different start conditions. The launcher model presented will be with six degrees of freedom (6DOF) and variable mass. The results analysed will be the flight parameters and ballistic performances. The discussions area will focus around the technical possibility to realize a small multi-stage launcher, by recycling military rocket motors. From technical point of view, the paper is focused on national project 'Suborbital Launcher for Testing' (SLT), which is based on hybrid propulsion and control systems, obtained through an original design. Therefore, while classical suborbital sounding rockets are unguided and they use as propulsion solid fuel motor having an uncontrolled ballistic flight, SLT project is introducing a different approach, by proposing the creation of a guided suborbital launcher, which is basically a satellite launcher at a smaller scale, containing its main subsystems. This is why the project itself can be considered an intermediary step in the development of a wider range of launching systems based on hybrid propulsion technology, which may have a major impact in the future European launchers programs. SLT project, as it is shown in the title, has two major objectives: first, a short term objective, which consists in obtaining a suborbital launching system which will be able to go into service in a predictable period of time, and a long term objective that consists in the development and testing of some unconventional sub-systems which will be integrated later in the satellite launcher as a part of the European space program. This is why the technical content of the project must be carried out beyond the range of the existing suborbital

  10. From human monocytes to genome-wide binding sites--a protocol for small amounts of blood: monocyte isolation/ChIP-protocol/library amplification/genome wide computational data analysis.

    Directory of Open Access Journals (Sweden)

    Sebastian Weiterer

    Full Text Available Chromatin immunoprecipitation in combination with a genome-wide analysis via high-throughput sequencing is the state of the art method to gain genome-wide representation of histone modification or transcription factor binding profiles. However, chromatin immunoprecipitation analysis in the context of human experimental samples is limited, especially in the case of blood cells. The typically extremely low yields of precipitated DNA are usually not compatible with library amplification for next generation sequencing. We developed a highly reproducible protocol to present a guideline from the first step of isolating monocytes from a blood sample to analyse the distribution of histone modifications in a genome-wide manner.The protocol describes the whole work flow from isolating monocytes from human blood samples followed by a high-sensitivity and small-scale chromatin immunoprecipitation assay with guidance for generating libraries compatible with next generation sequencing from small amounts of immunoprecipitated DNA.

  11. Lung fibrosis: drug screening and disease biomarker identification with a lung slice culture model and subtracted cDNA Library.

    Science.gov (United States)

    Guo, Tong; Lok, Ka Yee; Yu, Changhe; Li, Zhuo

    2014-09-01

    Pulmonary fibrosis is a progressive and irreversible disorder with no appropriate cure. A practical and effective experimental model that recapitulates the disease will greatly benefit the research community and, ultimately, patients. In this study, we tested the lung slice culture (LSC) system for its potential use in drug screening and disease biomarker identification. Fibrosis was induced by treating rat lung slices with 1ng/ml TGF-β1 and 2.5μM CdCl2, quantified by measuring the content of hydroxyproline, and confirmed by detecting the expression of collagen type III alpha 1 (Col3α1) and connective tissue growth factor (CTGF) genes. The anti-fibrotic effects of pirfenidone, spironolactone and eplerenone were assessed by their capability to reduce hydroxyproline content. A subtractive hybridisation technique was used to create two cDNA libraries (subtracted and unsubtracted) from lung slices. The housekeeping gene glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was employed to assess the subtraction efficiency of the subtracted cDNA library. Clones from the two libraries were sequenced and the genes were identified by performing a BLAST search on the NCBI GenBank database. Furthermore, the relevance of the genes to fibrosis formation was verified. The results presented here show that fibrosis was effectively induced in cultured lung slices, which exhibited significantly elevated levels of hydroxyproline and Col3α1/CTGF gene expression. Several inhibitors have demonstrated their anti-fibrotic effects by significantly reducing hydroxyproline content. The subtracted cDNA library, which was enriched for differentially expressed genes, was used to successfully identify genes associated with fibrosis. Collectively, the results indicate that our LSC system is an effective model for the screening of drug candidates and for disease biomarker identification.

  12. How Do We Manage? Project Management in Libraries: An Investigation

    National Research Council Canada - National Science Library

    Jenn Anne Horwath

    2012-01-01

    Despite the fact that libraries are undertaking projects to accomplish their goals and objectives, there is little information in the library literature about how libraries, large and small, are managing their projects...

  13. An open-source library for the numerical modeling of mass-transfer in solid oxide fuel cells

    Science.gov (United States)

    Novaresio, Valerio; García-Camprubí, María; Izquierdo, Salvador; Asinari, Pietro; Fueyo, Norberto

    2012-01-01

    The generation of direct current electricity using solid oxide fuel cells (SOFCs) involves several interplaying transport phenomena. Their simulation is crucial for the design and optimization of reliable and competitive equipment, and for the eventual market deployment of this technology. An open-source library for the computational modeling of mass-transport phenomena in SOFCs is presented in this article. It includes several multicomponent mass-transport models ( i.e. Fickian, Stefan-Maxwell and Dusty Gas Model), which can be applied both within porous media and in porosity-free domains, and several diffusivity models for gases. The library has been developed for its use with OpenFOAM ®, a widespread open-source code for fluid and continuum mechanics. The library can be used to model any fluid flow configuration involving multicomponent transport phenomena and it is validated in this paper against the analytical solution of one-dimensional test cases. In addition, it is applied for the simulation of a real SOFC and further validated using experimental data. Program summaryProgram title: multiSpeciesTransportModels Catalogue identifier: AEKB_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEKB_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU General Public License No. of lines in distributed program, including test data, etc.: 18 140 No. of bytes in distributed program, including test data, etc.: 64 285 Distribution format: tar.gz Programming language:: C++ Computer: Any x86 (the instructions reported in the paper consider only the 64 bit case for the sake of simplicity) Operating system: Generic Linux (the instructions reported in the paper consider only the open-source Ubuntu distribution for the sake of simplicity) Classification: 12 External routines: OpenFOAM® (version 1.6-ext) ( http://www.extend-project.de) Nature of problem: This software provides a library of models for

  14. Organising the Digitisation of Collections at a National or International Level: Models for Research Library Development

    Directory of Open Access Journals (Sweden)

    Daniel Renoult

    2000-06-01

    Full Text Available Libraries today, amongst other research institutions, are solicited more and more to take part in programmes of digitisation of their collections. Apart from the way these programmes affect the public image of the institution and the prestige that is to be gained, participating in these programmes leads us to consider not only technical decisions but above all long term strategic choices.

  15. Democratizing Human Genome Project Information: A Model Program for Education, Information and Debate in Public Libraries.

    Science.gov (United States)

    Pollack, Miriam

    The "Mapping the Human Genome" project demonstrated that librarians can help whomever they serve in accessing information resources in the areas of biological and health information, whether it is the scientists who are developing the information or a member of the public who is using the information. Public libraries can guide library…

  16. Common Ground: Exploring Compatibilities between the Linked Data Models of the Library of Congress and OCLC

    Science.gov (United States)

    Godby, Carol Jean; Denenberg, Ray

    2015-01-01

    Jointly released by OCLC and the Library of Congress, this white paper compares and contrasts the compatible linked data initiatives at both institutions. It is an executive summary of a more detailed technical analysis that will be released later this year. The white paper summarizes the recent activity of the Bibliographic Framework Initiative…

  17. Depository Libraries and Public Services.

    Science.gov (United States)

    Kessler, Ridley

    1998-01-01

    Discusses the Wright State University (Ohio) Library policy directive on customer service, and suggests this document as a model to follow in setting up service standards or guidelines for depository-library services. Draft-depository library public-service guidelines for government information in electronic format are appended. (JAK)

  18. Mobile library services best practices

    CERN Document Server

    Harmon, Charles

    2013-01-01

    Mobile Library Services provides 11 proven ways to reach out to mobile users and increase your library's relevance to their day-to-day lives. Librarians detail how they created mobile apps to how they went mobile on a shoestring budget. Written by public, academic, and special librarians, these 11 best practices offer models for libraries of every type and size.

  19. Reference Services in Australian Academic Libraries are Becoming More Multifaceted, A Review of: Burke, L. “Models of Reference Services in Australian Academic Libraries.” Journal of Librarianship and Information Science 40.4 (2008: 269‐86.

    Directory of Open Access Journals (Sweden)

    David Herron

    2009-09-01

    Full Text Available Objective – To investigate the current organizational models for reference work in Australian academic libraries, and how these reference services are staffed.Design – Mixed methods.Setting – Academic universities in Australia.Subjects – Forty Council of Australian University Librarians (CAUL member libraries.Methods – A literature study was undertaken to (1 find a definition of reference services and (2 explore the development of reference service models over time. Statistics from the CAUL member libraries were studied for trends in student population and number of academic and library staff. A web‐based survey, with questions based on the findings in the literature study, was then distributed to the 40 Australian university libraries in 2006. Respondents were asked when the library commenced different reference services in five areas: formats in which the library received and responded to reference queries, information literacy, subject specialization, liaison activities, and collection development. Respondents also answered questions about the organization of the reference department, including: whether they had a separate or integrated model; the size of the reference collections; if they had a librarian dedicated to supporting students studying in remote or distant mode; if the interlibrary loans department was part of the suite of reference services; and if they had a mission or statement of purpose for their reference services department.Main Results – Based on the literature study, the working definition of reference services (1 for the project was “all activities which assist in providing relevant and appropriate information services to patrons” (270, including:•All interactions with patrons to assist them in their searches for information in all media types.•All training by librarians of patrons to be able to access information for themselves.•Activities to help the library stay informed of relevant developments

  20. Developing a Suitable Model for Water Uptake for Biodegradable Polymers Using Small Training Sets

    Directory of Open Access Journals (Sweden)

    Loreto M. Valenzuela

    2016-01-01

    Full Text Available Prediction of the dynamic properties of water uptake across polymer libraries can accelerate polymer selection for a specific application. We first built semiempirical models using Artificial Neural Networks and all water uptake data, as individual input. These models give very good correlations (R2>0.78 for test set but very low accuracy on cross-validation sets (less than 19% of experimental points within experimental error. Instead, using consolidated parameters like equilibrium water uptake a good model is obtained (R2=0.78 for test set, with accurate predictions for 50% of tested polymers. The semiempirical model was applied to the 56-polymer library of L-tyrosine-derived polyarylates, identifying groups of polymers that are likely to satisfy design criteria for water uptake. This research demonstrates that a surrogate modeling effort can reduce the number of polymers that must be synthesized and characterized to identify an appropriate polymer that meets certain performance criteria.

  1. Cost Accounting and Analysis for University Libraries.

    Science.gov (United States)

    Leimkuhler, Ferdinand F.; Cooper, Michael D.

    The approach to library planning studied in this report is the use of accounting models to measure library costs and implement program budgets. A cost-flow model for a university library is developed and listed with historical data from the Berkeley General Library. Various comparisons of an exploratory nature are made of the unit costs for…

  2. Modeling Small Scale Solar Powered ORC Unit for Standalone Application

    Directory of Open Access Journals (Sweden)

    Enrico Bocci

    2012-01-01

    Full Text Available When the electricity from the grid is not available, the generation of electricity in remote areas is an essential challenge to satisfy important needs. In many developing countries the power generation from Diesel engines is the applied technical solution. However the cost and supply of fuel make a strong dependency of the communities on the external support. Alternatives to fuel combustion can be found in photovoltaic generators, and, with suitable conditions, small wind turbines or microhydroplants. The aim of the paper is to simulate the power generation of a generating unit using the Rankine Cycle and using refrigerant R245fa as a working fluid. The generation unit has thermal solar panels as heat source and photovoltaic modules for the needs of the auxiliary items (pumps, electronics, etc.. The paper illustrates the modeling of the system using TRNSYS platform, highlighting standard and “ad hoc” developed components as well as the global system efficiency. In the future the results of the simulation will be compared with the data collected from the 3 kW prototype under construction in the Tuscia University in Italy.

  3. Libraries Today, Libraries Tomorrow: Contemporary Library Practices and the Role of Library Space in the L

    Directory of Open Access Journals (Sweden)

    Ana Vogrinčič Čepič

    2013-09-01

    Full Text Available ABSTRACTPurpose: The article uses sociological concepts in order to rethink the changes in library practices. Contemporary trends are discussed with regard to the changing nature of working habits, referring mostly to the new technology, and the (emergence of the third space phenomenon. The author does not regard libraries only as concrete public service institutions, but rather as complex cultural forms, taking in consideration wider social context with a stress on users’ practices in relation to space.Methodology/approach: The article is based on the (self- observation of the public library use, and on the (discourse analysis of internal library documents (i.e. annual reports and plans and secondary sociological literature. As such, the cultural form approach represents a classic method of sociology of culture.Results: The study of relevant material in combination with direct personal experiences reveals socio-structural causes for the change of users’ needs and habits, and points at the difficulty of spatial redefinition of libraries as well as at the power of the discourse.Research limitations: The article is limited to an observation of users’ practices in some of the public libraries in Ljubljana and examines only a small number of annual reports – the discoveries are then further debated from the sociological perspective.Originality/practical implications: The article offers sociological insight in the current issues of the library science and tries to suggest a wider explanation that could answer some of the challenges of the contemporary librarianship.

  4. Public Opinion and the Funding of Public Libraries.

    Science.gov (United States)

    Allen, Bryce

    2003-01-01

    This investigation compared self-reported use of public libraries and public opinion about library services with levels of per-capita library funding over time. Results showed a small relationship between self-reported use of libraries and levels of library funding. There was no relationship between public opinion and funding levels. Non-economic…

  5. Stochastic modelling and diffusion modes for POD models and small-scale flow analysis

    CERN Document Server

    Resseguier, Valentin; Heitz, Dominique; Chapron, Bertrand

    2016-01-01

    We introduce a stochastic modelling in the constitution of fluid flow reduced-order models. This framework introduces a spatially inhomogeneous random field to represent the unresolved small-scale velocity component. Such a decomposition of the velocity in terms of a smooth large-scale velocity component and a rough, highly oscillating, component gives rise, without any supplementary assumption, to a large-scale flow dynamics that includes a modified advection term together with an inhomogeneous diffusion term. Both of those terms, related respectively to turbophoresis and mixing effects, depend on the variance of the unre-solved small-scale velocity component. They bring to the reduced system an explicit subgrid term enabling to take into account the action of the truncated modes. Besides, a decomposition of the variance tensor in terms of diffusion modes provides a meaningful statistical representation of the stationary or nonstationary structuration of the small-scale velocity and of its action on the reso...

  6. 图书馆个性化服务模式的展望%Prospect of Individualization Service Model in Library

    Institute of Scientific and Technical Information of China (English)

    冯莉; 刘甲

    2011-01-01

    针对图书馆的个性化服务模式展望作者提出了图书馆个性化服务的模式含义.以及图书馆个性化信息服务模式的实现进行阐述.%The author put forward the meaning of library's individualization service in view of the model of library's individualization service. It also discusses the realization method of library's individualization service.

  7. SERVQUAL MODEL IMPLEMENTATION FOR EVALUATING QUALITY SERVICE OF THE LIBRARY OF HIGHER EDUCATIONINSTITUTION IN BOTUCATU REGION

    OpenAIRE

    2014-01-01

    Currently technology colleges are growing and gaining market share. So, it is of paramount importance a careful evaluation of the most important components in an institution of higher education, the library, which is fundamental for the development of future professionals. Therefore, the implementation of a tool to measure and compare results through user satisfaction in relation to services provided to a particular service is required. SERVQUAL is a measurement tool, used in t...

  8. Subject indexing in the Portuguese polytechnic libraries: proposing a simplified model to make it possible

    OpenAIRE

    Martins, Mª Catarina Barradas

    2014-01-01

    Academic libraries are still working based on the traditional documentation techniques of cataloguing and indexing. The research about subject access in OPACs has demonstrated that inadequate indexing policies have negative influence on the way users search the catalogs: subject indexing and retrieval have a direct correspondence. Searching by subject in bibliographic catalogs must be, as much as possible, a successful experience for the users, and consistent subject indexes contribute to a m...

  9. The academic library network

    Directory of Open Access Journals (Sweden)

    Jacek Wojciechowski

    2012-01-01

    Full Text Available The efficiency of libraries, academic libraries in particular, necessitates organizational changes facilitating or even imposing co-operation. Any structure of any university has to have an integrated network of libraries, with an appropriate division of work, and one that is consolidated as much as it is possible into medium-size or large libraries. Within thus created network, a chance arises to centralize the main library processes based on appropriate procedures in the main library, highly specialized, more effective and therefore cheaper in operation, including a co-ordination of all more important endeavours and tasks. Hierarchically subordinated libraries can be thus more focused on performing their routine service, more and more frequently providing for the whole of the university, and being able to adjust to changeable requirements and demands of patrons and of new tasks resulting from the new model of the university operation. Another necessary change seems to be a universal implementation of an ov rall programme framework that would include all services in the university’s library networks.

  10. SOSpin, a C++ library for Yukawa decomposition in $\\mathsf{SO}(2N)$ models

    CERN Document Server

    Cardoso, Nuno; Gonçalves, Nuno; Simoes, C

    2015-01-01

    We present in this paper the SOSpin library, which calculates an analytic decomposition of the Yukawa interactions invariant under any $\\mathsf{SO}(2N)$ group in terms of an $\\mathsf{SU}(N)$ basis. We make use of the oscillator expansion formalism, where the $\\mathsf{SO}(2N)$ spinor representations are expressed in terms of creation and annihilation operators of a Grassmann algebra. These noncommutative operators and their products are simulated in SOSpin through the implementation of doubly-linked-list data structures. These data structures were determinant to achieve a higher performance in the simplification of large products of creation and annihilation operators. We illustrate the use of our library with complete examples of how to decompose Yukawa terms invariant under $\\mathsf{SO}(2N)$ in terms of $\\mathsf{SU}(N)$ degrees of freedom for $N=2$ and $5$. We further demonstrate, with an example for $\\mathsf{SO}(4)$, that higher dimensional field-operator terms can also be processed with our library. Finall...

  11. Multiobjective Bak-Sneppen model on a small-world network

    Energy Technology Data Exchange (ETDEWEB)

    Elettreby, M.F. [Department of Mathematics, Faculty of Science, Mansoura University, Mansoura 35516 (Egypt)] e-mail: mohfathy@mans.edu.eg

    2005-11-01

    Small-world networks (SWN) are relevant to biological systems. We study the dynamics of the Bak-Sneppen (BS) model on small-world network, including the concepts of extremal dynamics, multiobjective optimization and coherent noise. We find that the small-world structure stabilizes the system. Also, it is more realistic to augment the Bak-Sneppen model by these concepts.

  12. A geometric growth model interpolating between regular and small-world networks

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Zhongzhi [Department of Computer Science and Engineering, Fudan University, Shanghai 200433 (China); Zhou, Shuigeng [Department of Computer Science and Engineering, Fudan University, Shanghai 200433 (China); Wang, Zhiyong [Department of Computer Science and Engineering, Fudan University, Shanghai 200433 (China); Shen, Zhen [Department of Computer Science and Engineering, Fudan University, Shanghai 200433 (China)

    2007-09-28

    We propose a geometric growth model which interpolates between one-dimensional linear graphs and small-world networks. The model undergoes a transition from large to small worlds. We study the topological characteristics by both theoretical predictions and numerical simulations, which are in good accordance with each other. Our geometrically growing model is a complementarity for the static WS model.

  13. Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture.

    Science.gov (United States)

    de Wilde, Adriaan H; Jochmans, Dirk; Posthuma, Clara C; Zevenhoven-Dobbe, Jessika C; van Nieuwkoop, Stefan; Bestebroer, Theo M; van den Hoogen, Bernadette G; Neyts, Johan; Snijder, Eric J

    2014-08-01

    Coronaviruses can cause respiratory and enteric disease in a wide variety of human and animal hosts. The 2003 outbreak of severe acute respiratory syndrome (SARS) first demonstrated the potentially lethal consequences of zoonotic coronavirus infections in humans. In 2012, a similar previously unknown coronavirus emerged, Middle East respiratory syndrome coronavirus (MERS-CoV), thus far causing over 650 laboratory-confirmed infections, with an unexplained steep rise in the number of cases being recorded over recent months. The human MERS fatality rate of ∼ 30% is alarmingly high, even though many deaths were associated with underlying medical conditions. Registered therapeutics for the treatment of coronavirus infections are not available. Moreover, the pace of drug development and registration for human use is generally incompatible with strategies to combat emerging infectious diseases. Therefore, we have screened a library of 348 FDA-approved drugs for anti-MERS-CoV activity in cell culture. If such compounds proved sufficiently potent, their efficacy might be directly assessed in MERS patients. We identified four compounds (chloroquine, chlorpromazine, loperamide, and lopinavir) inhibiting MERS-CoV replication in the low-micromolar range (50% effective concentrations [EC(50)s], 3 to 8 μM). Moreover, these compounds also inhibit the replication of SARS coronavirus and human coronavirus 229E. Although their protective activity (alone or in combination) remains to be assessed in animal models, our findings may offer a starting point for treatment of patients infected with zoonotic coronaviruses like MERS-CoV. Although they may not necessarily reduce viral replication to very low levels, a moderate viral load reduction may create a window during which to mount a protective immune response.

  14. Structural libraries of protein models for multiple species to understand evolution of the renin-angiotensin system.

    Science.gov (United States)

    Prokop, Jeremy W; Petri, Victoria; Shimoyama, Mary E; Watanabe, Ingrid K M; Casarini, Dulce E; Leeper, Thomas C; Bilinovich, Stephanie M; Jacob, Howard J; Santos, Robson A S; Martins, Almir S; Araujo, Fabiano C; Reis, Fernando M; Milsted, Amy

    2015-05-01

    The details of protein pathways at a structural level provides a bridge between genetics/molecular biology and physiology. The renin-angiotensin system is involved in many physiological pathways with informative structural details in multiple components. Few studies have been performed assessing structural knowledge across the system. This assessment allows use of bioinformatics tools to fill in missing structural voids. In this paper we detail known structures of the renin-angiotensin system and use computational approaches to estimate and model components that do not have their protein structures defined. With the subsequent large library of protein structures, we then created a species specific protein library for human, mouse, rat, bovine, zebrafish, and chicken for the system. The rat structural system allowed for rapid screening of genetic variants from 51 commonly used rat strains, identifying amino acid variants in angiotensinogen, ACE2, and AT1b that are in contact positions with other macromolecules. We believe the structural map will be of value for other researchers to understand their experimental data in the context of an environment for multiple proteins, providing pdb files of proteins for the renin-angiotensin system in six species. With detailed structural descriptions of each protein, it is easier to assess a species for use in translating human diseases with animal models. Additionally, as whole genome sequencing continues to decrease in cost, tools such as molecular modeling will gain use as an initial step in designing efficient hypothesis driven research, addressing potential functional outcomes of genetic variants with precompiled protein libraries aiding in rapid characterizations.

  15. Library Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Carnegie Library of Pittsburgh locations including address, coordinates, phone number, square footage, and standard operating hours.

  16. Cost Models in Digital Archiving: An overview of Life Cycle Management at the National Library of the Netherlands

    Directory of Open Access Journals (Sweden)

    Erik Oltmans

    2004-10-01

    Full Text Available The number of institutions that are either considering the implementation of a digital archive or already started with an operational digital archive service is increasing. While technological and organisational challenges are well-studied and in few cases even well-defined, the subject of costs often remains untouched, which in many cases prevent organisations from new initiatives. In this paper two leading digital preservation techniques - migration and emulation - will be discussed in terms of life cycle management and associated cost models. Both techniques are studied and considered for implementation at the Koninklijke Bibliotheek, National Library of the Netherlands.

  17. Modeling a Library Web Site Redesign Process: Developing a User-Centered Web Site Through Usability Testing

    Directory of Open Access Journals (Sweden)

    Danielle A. Becker

    2013-03-01

    Full Text Available This article presents a model for creating a strong, user-centered web presence by pairing usability testing and the design process. Four rounds of usability testing were conducted throughout the process of building a new academic library web site. Participants were asked to perform tasks using a talk-aloud protocol. Tasks were based on guiding principles of web usability that served as a framework for the new site. Results from this study show that testing throughout the design process is an effective way to build a web site that not only reflects user needs and preferences, but can be easily changed as new resources and technologies emerge.

  18. A Model Job Training Program for Summer Youth: Library Interns at Grambling State University, A.C. Lewis Memorial Library, Grambling, Louisiana.

    Science.gov (United States)

    Carroll, Sally; Stokley, Sandra

    1999-01-01

    A six-week university library intern program sponsored by the Job Training Partnership Act investigated the impact of 12 economically disadvantaged high school students working at Grambling State University (Louisiana). Interns succeeded, learned skills later described on their resumes and job application letters, and gained self-esteem and job…

  19. America's Star Libraries: Top-Rated Libraries

    Science.gov (United States)

    Lance, Keith Curry; Lyons, Ray

    2009-01-01

    "Library Journal"'s national rating of public libraries, the "LJ" Index of Public Library Service 2009, Round 2, identifies 258 "star" libraries. Created by Keith Curry Lance and Ray Lyons and based on 2007 data from the IMLS, it rates 7,268 public libraries. The top libraries in each group get five, four, or three stars. All included libraries,…

  20. America's Star Libraries: Top-Rated Libraries

    Science.gov (United States)

    Lance, Keith Curry; Lyons, Ray

    2009-01-01

    "Library Journal"'s national rating of public libraries, the "LJ" Index of Public Library Service 2009, Round 2, identifies 258 "star" libraries. Created by Keith Curry Lance and Ray Lyons and based on 2007 data from the IMLS, it rates 7,268 public libraries. The top libraries in each group get five, four, or three stars. All included libraries,…

  1. 图书馆精神的救赎——榜样教育%Salvation of Library Spirit --Model Education

    Institute of Scientific and Technical Information of China (English)

    陈文革

    2011-01-01

    The reason of library job burnout is the intelligence materialization. Library job burnout embodys development economism, social values orientated at money, cognitive bias of librarian values and library engaged in business. Library job burnout endangers the development of librarians and libraries, its substance is lack of library spirit. Model education could nurture library spirit effectively and overcome job burnout, so as to promote the development of librarianship.%图书馆职业懈怠产生的原因在于智力物化,具体表现为发展唯经济论、社会价值取向金钱化、图书馆员价值认知偏差、图书馆经营化4个方面。图书馆职业懈怠危害了馆员个人和图书馆事业的发展,其实质是图书馆精神缺失。开展图书馆榜样教育可以有效培育图书馆精神,克服职业懈怠,从而推动图书馆事业发展。

  2. Enantioselective Benzylic Hydroxylation Catalysed by P450 Monooxygenases: Characterisation of a P450cam Mutant Library and Molecular Modelling.

    Science.gov (United States)

    Eichler, Anja; Gricman, Łukasz; Herter, Susanne; Kelly, Paul P; Turner, Nicholas J; Pleiss, Jürgen; Flitsch, Sabine L

    2016-03-02

    Cytochrome P450 monooxygenases can catalyse the stereoselective C-H activation of a very broad range of substrates. Prediction and control of enantioselectivity of this enzyme class is of great interest for the synthesis of high-value chiral molecules. Here we have used a combination of molecular dynamics simulations and experimental screening to study the enantioselectivity of a library of active-site mutants of chimeric P450cam-RhFRed towards the benzylic hydroxylation of structurally related regioisomers of ethylmethylbenzene. Small variations either in substrate structure or in enzyme active site architecture were shown to lead to dramatic changes in enantioselectivity; this was broadly in agreement with computational predictions. In addition to validating computational approaches, these studies have provided us with a deeper understanding of effects that might control stereoselectivity in these biooxidation reactions.

  3. An expressed sequence tag (EST library for Drosophila serrata, a model system for sexual selection and climatic adaptation studies

    Directory of Open Access Journals (Sweden)

    McGraw Elizabeth A

    2009-01-01

    Full Text Available Abstract Background The native Australian fly Drosophila serrata belongs to the highly speciose montium subgroup of the melanogaster species group. It has recently emerged as an excellent model system with which to address a number of important questions, including the evolution of traits under sexual selection and traits involved in climatic adaptation along latitudinal gradients. Understanding the molecular genetic basis of such traits has been limited by a lack of genomic resources for this species. Here, we present the first expressed sequence tag (EST collection for D. serrata that will enable the identification of genes underlying sexually-selected phenotypes and physiological responses to environmental change and may help resolve controversial phylogenetic relationships within the montium subgroup. Results A normalized cDNA library was constructed from whole fly bodies at several developmental stages, including larvae and adults. Assembly of 11,616 clones sequenced from the 3' end allowed us to identify 6,607 unique contigs, of which at least 90% encoded peptides. Partial transcripts were discovered from a variety of genes of evolutionary interest by BLASTing contigs against the 12 Drosophila genomes currently sequenced. By incorporating into the cDNA library multiple individuals from populations spanning a large portion of the geographical range of D. serrata, we were able to identify 11,057 putative single nucleotide polymorphisms (SNPs, with 278 different contigs having at least one "double hit" SNP that is highly likely to be a real polymorphism. At least 394 EST-associated microsatellite markers, representing 355 different contigs, were also found, providing an additional set of genetic markers. The assembled EST library is available online at http://www.chenowethlab.org/serrata/index.cgi. Conclusion We have provided the first gene collection and largest set of polymorphic genetic markers, to date, for the fly D. serrata. The EST

  4. A complete library of X-ray pulsars in the Magellanic Clouds: A new resource for modeling the time evolution of luminosity and pulse profile

    Science.gov (United States)

    Yang, Jun; Laycock, Silas; Christodoulou, Dimitris; Fingerman, Samuel; Cappallo, Rigel; Zezas, Andreas; Antoniou, Vallia; Hong, Jaesub; Ho, Wynn; Coe, Malcolm; Klus, Helen

    2016-01-01

    We have collected and analyzed all XMM-Newton and Chandra (˜ 300) observations of the known pulsars in the Small & Large Magellanic Clouds (SMC, LMC). We aim to classify various pulsar properties with amplitude logLX = 33 ˜ 38 erg/s and incorporate the related parameters in theoretical models. With the high time-resolution data from the European Photon Imaging Camera (EPIC) and the latest calibration files and the Science Analysis System (SAS) software from High Energy Astrophysics Science Archive Research Center Software (HEASOFT), our pipeline generates a suite of useful products for each pulsar detection: point-source event lists, pulse profiles, periodograms, and spectra for the broad energy band, the soft band (0.2-2 keV), and the hard band (2-12 keV). Of 59 SMC pulsars in the EPIC field of view, we were able to measure 29 with pulse periods and power spectra. From XMM for example, for 16 of them, we find 12 are spinning up and 4 are spinning down. We also compare the observed pulse profiles to geometric models of the pulsars in order to constrain the magnetospheric parameters of each of these sources. Our motivation is to provide a library for time domain studies and profile modeling.

  5. Learning Commons in Academic Libraries

    Directory of Open Access Journals (Sweden)

    Larisa González Martínez

    2015-01-01

    Full Text Available Like all human creations, institutions transform and evolve over time. Libraries also have changed to respond the needs of its users. Academic libraries physical spaces are one of the turned aspects, an example are the Learning Commons (spaces for collaborative work in academic libraries. The main purpose of this paper is to expose the characteristics of the Learning Commons model with a brief account of the history of planning and construction of academic libraries. This paper also aims to present the manner in which a Learning Commons has been implemented at the library of Instituto Tecnológico y de Estudios Superiores de Monterrey (ITESM, Campus Monterrey in Mexico.

  6. Model-based Small Area Estimates of Cancer Risk Factors and Screening Behaviors - Small Area Estimates

    Science.gov (United States)

    These model-based estimates use two surveys, the Behavioral Risk Factor Surveillance System (BRFSS) and the National Health Interview Survey (NHIS). The two surveys are combined using novel statistical methodology.

  7. Rethinking library service to distance education students: analyzing the embedded librarian model.

    Science.gov (United States)

    Sullo, Elaine; Harrod, Tom; Butera, Gisela; Gomes, Alexandra

    2012-01-01

    Since fall 2009, reference librarians at The George Washington University's Himmelfarb Health Sciences Library have been embedded in online classes through Blackboard within the School of Nursing and School of Medicine and Health Sciences. The authors sought to determine the types of questions asked of the librarian, with the goal of informing future interactions with distance education classes to help develop a standard "protocol" for working with this population of students. Eighty-two questions were categorized and qualitatively analyzed. The findings have prompted librarians to explore tools such as Elluminate Live!, a tool that allows librarians to provide synchronous instruction within the Blackboard environment.

  8. Library Research.

    Science.gov (United States)

    Wright, Nancy Kirkpatrick

    This workbook, designed for a Library Research course at Yavapai College, provides 15 lessons in advanced library reference skills. Each lesson provides explanatory text and reinforcement exercises. After Lesson I introduces specialized dictionaries and encyclopedias (e.g., for foreign languages, medicine, music, economics, social sciences, and…

  9. Privatizing Libraries

    Science.gov (United States)

    Jerrard, Jane; Bolt, Nancy; Strege, Karen

    2012-01-01

    This timely special report from ALA Editions provides a succinct but comprehensive overview of the "privatization" of public libraries. It provides a history of the trend of local and state governments privatizing public services and assets, and then examines the history of public library privatization right up to the California…

  10. Privatizing Libraries

    Science.gov (United States)

    Jerrard, Jane; Bolt, Nancy; Strege, Karen

    2012-01-01

    This timely special report from ALA Editions provides a succinct but comprehensive overview of the "privatization" of public libraries. It provides a history of the trend of local and state governments privatizing public services and assets, and then examines the history of public library privatization right up to the California legislation…

  11. 微量RNA的cDNA PCR文库的构建%The Construction of cDNA PCR Library from a Small Amount of RNA

    Institute of Scientific and Technical Information of China (English)

    李晶泉; 袁晓东; 汤敏谦

    2001-01-01

    By the method of PCR (Polymerase Chain Reaction),we have constructed the cDNA PCR library from mRNA.The cDNA PCR library can amplify the original cDNA up to hundreds of times.With the total RNA of human K562 cultured cell,the cDNA of β-Actin has been obtained by the methods of cDNA PCR library and reverse transcription respectively.As contrast,the amount of β-Actin′s cDNA from the cDNA PCR library is much higher than from reverse transcription.75pg total RNA of human K562 Cultured cell is employed to construct 50μl cDNA PCR library,and the cDNA of β-Actin can even be detected by using 1μl of the library as template to perform the PCR.Therefore cDNA PCR library can greatly enlarge the amount of information.%使用PCR(polymerase chain reaction)技术,调制了mRNA的cDNA PCR文库,实验证明,cDNA PCR文库能使原cDNA的量放大数百倍。同时,使用人体K562培养细胞的总RNA,对cDNA PCR文库法和反转录中的β-Actin的cDNA量进行了比较,cDNA PCR文库法中的β-Actin的cDNA量大大高于反转录中的β-Actin的cDNA量。使用75pg的人体K562培养细胞的总RNA,调制成50μl的cDNA PCR文库,使用1μl的cDNA PCR文库进行PCR反应时,可对文库中的β-Actin的cDNA进行PCR检测。因此,cDNA PCR文库显示了良好的信息放大性能。

  12. Experimental models of small intestinal transplantation in rats: orthotopic versus heterotopic model.

    Directory of Open Access Journals (Sweden)

    Nakao A

    2002-04-01

    Full Text Available Two kinds of surgical models of small intestinal transplantation (SITx in rats, namely heterotopic (HIT and orthotopic transplantion (OIT, have been reviewed. In OIT, the small intestine of the recipient is removed and the transplanted intestine replaces it in continuity. On the other hand, in the HIT model, the small intestinal grafts are rendered dysfunctional without alimentary tract continuity. Histological evidence showed that acute rejection appeared earlier in HIT as compared to OIT. Hyperplasia and hypertrophy of the muscularis externa produced in the chronic rejection process were more pronounced in HIT allografts. The HIT grafts showed severe mucosal atrophy due to the lack of intraluminal trophic factors, because oral feedings can stimulate tropic hormones for mucosal growth, and provide nutrients for enterocytes. Intestinal permeability was consistently higher after HIT than after OIT. The HIT grafts demonstrated less contractility and less response to chemical stimulation than did OIT grafts. The OIT models are advantageous in studies of intraluminal nutrients, and intestinal secretions in these models might modulate the intestinal immune status and possibly delay rejection. The superior intestinal barrier function and the delayed onset of rejection in OIT rats suggest that nutrients and other factors in the succus entericus are important for the maintenance of intestinal graft function.

  13. Interior Ballistics Modeling Applied to Small Arms Systems

    Science.gov (United States)

    1979-06-01

    ball cartridge M2, Projectile weight 150 grains (9.72 x I0-3 kg) Propellant weight 49.9 grains (3.23 x l0" kg) Bore area 0.0732 in.’ (4.72 x 10" mi...recoil (ref. Si). The small bore area of small arms also creates greater problems with heat transfer and erosion (ref. 52). Gas Transmission Systems...34 Olin Corporation, Winchester Western Division Technical Report WWR-68-2, 15 January 1968 I 11. B.W. Brodman , M.P. Devine, and M.T. Gurbarg

  14. Large Spectral Library Problem

    Energy Technology Data Exchange (ETDEWEB)

    Chilton, Lawrence K.; Walsh, Stephen J.

    2008-10-03

    Hyperspectral imaging produces a spectrum or vector at each image pixel. These spectra can be used to identify materials present in the image. In some cases, spectral libraries representing atmospheric chemicals or ground materials are available. The challenge is to determine if any of the library chemicals or materials exist in the hyperspectral image. The number of spectra in these libraries can be very large, far exceeding the number of spectral channels collected in the ¯eld. Suppose an image pixel contains a mixture of p spectra from the library. Is it possible to uniquely identify these p spectra? We address this question in this paper and refer to it as the Large Spectral Library (LSL) problem. We show how to determine if unique identi¯cation is possible for any given library. We also show that if p is small compared to the number of spectral channels, it is very likely that unique identi¯cation is possible. We show that unique identi¯cation becomes less likely as p increases.

  15. EST sequencing and fosmid library construction in a non-model moth, Mamestra brassicae, for comparative mapping.

    Science.gov (United States)

    Kamimura, Manabu; Tateishi, Ken; Tanaka-Okuyama, Makiko; Okabe, Takuya; Shibata, Fukashi; Sahara, Ken; Yasukochi, Yuji

    2012-11-01

    Genome data are useful for both basic and applied research; however, it is difficult to carry out large-scale genome analyses using species with limited genetic or genomic resources. Here, we describe a cost-effective method to analyze the genome of a non-model species, using the cabbage moth, Mamestra brassicae (Lepidoptera: Noctuidae). First, we conducted expression sequence tag (EST) analysis. In this analysis, we performed PCR-based prescreening of a non-normalized embryonic cDNA library to eliminate already sequenced cDNAs from further sequencing, which significantly increased the percentage of unique genes. Next, we constructed a fosmid library of M. brassicae and isolated 120 clones containing 119 putative single copy genes by PCR-based screening with primer sets designed from the ESTs. Finally, we showed that the isolated fosmid clones could be used as probes for multicolor fluorescence in situ hybridization (FISH) analysis against an M. brassicae chromosome and confirmed conserved gene order between M. brassicae and the silkworm, Bombyx mori. Thus, we developed new genomic resources for comparative genome analysis in M. brassicae using robust and relatively low cost methods that can be applied to any non-model organism.

  16. Grading Model of College Library Crisis Management%高校图书馆危机管理之分级模式

    Institute of Scientific and Technical Information of China (English)

    裴允; 陈颖颖; 郭楠; 赵婷

    2011-01-01

    高校图书馆危机管理的能力与成效直接关系到图书馆服务的质量及声誉,甚至关系到学校的整体形象.本文根据危机的强度与频度对高校图书馆的危机进行分级,并制定相应的预警和对策,为高校图书馆危机管理提供了一个全新的管理模式.%The ability and effectiveness of university library crisis management are directly related to library services quality and reputation, even to the school's overall image.Based on the intensity and frequency of the crisis, the university library crises are graded, and appropriate early warning and response are made, providing a new management model for crisis management of university library.

  17. 图书馆知识共享空间模型构建研究%Research on a Model of Library Knowledge Commons

    Institute of Scientific and Technical Information of China (English)

    朱红涛; 周九常; 胡守敏

    2011-01-01

    图书馆知识共享空间是满足用户知识共享活动服务需求的重要平台和场所。文章在界定图书馆知识共享空间概念的基础上,分析图书馆知识共享空间运行需求,构建出包括知识共享平台、知识资源供给等模块的图书馆知识共享空间模型。%Library knowledge commons is an important platform and location by which libraries provide services for users' knowledge sharing.Based on defining the conception of library knowledge commons,the authors analyze its operating needs,and then construct a model of library knowledge commons,which includes knowledge sharing platform,knowledge resources supply,and other modules.

  18. News from the Library: The 'long tail' Library

    CERN Multimedia

    CERN Library

    2012-01-01

    "The term 'long tail' has gained popularity in recent times as describing the retailing strategy of selling a large number of unique items with relatively small quantities sold of each usually in addition to selling fewer popular items in large quantities. The long tail was popularized by Chris Anderson, who mentioned Amazon.com, Apple and Yahoo! as examples of businesses applying this strategy." *   If we leave the business environment and move to the world of libraries, we still see this "long tail". Usually, only a small portion of a library's book collection accounts for the majority of its loans. On the other hand, there are a variety of "niche information needs" that might not be met, as libraries cannot afford to build up huge collections of documents available just-in-case. However, the networked environment of today's libraries can offer a solution. Online networks of libraries ca...

  19. SiRNA sequence model: redesign algorithm based on available genome-wide libraries.

    Science.gov (United States)

    Kozak, Karol

    2013-12-01

    The evolution of RNA interference (RNAi) and the development of technologies exploiting its biology have enabled scientists to rapidly examine the consequences of depleting a particular gene product in cells. Design tools have been developed based on experimental data to increase the knockdown efficiency of siRNAs. Not all siRNAs that are developed to a given target mRNA are equally effective. Currently available design algorithms take an accession, identify conserved regions among their transcript space, find accessible regions within the mRNA, design all possible siRNAs for these regions, filter them based on multi-scores thresholds, and then perform off-target filtration. These different criteria are used by commercial suppliers to produce siRNA genome-wide libraries for different organisms. In this article, we analyze existing siRNA design algorithms and evaluate weight of design parameters for libraries produced in the last decade. We proved that not all essential parameters are currently applied by siRNA vendors. Based on our evaluation results, we were able to suggest an siRNA sequence pattern. The findings in our study can be useful for commercial vendors improving the design of RNAi constructs, by addressing both the issue of potency and the issue of specificity.

  20. inverse gaussian model for small area estimation via gibbs sampling

    African Journals Online (AJOL)

    ADMIN

    ... for the factor effects is motivated from the context of the ... extremely useful in small area estimation theory, where one can ... study as the ten regions stratified by six education classes. .... The expectation of a function g(θ) of the parameters is ...... money income. .... included in the paper in the interest of saving space.

  1. Testing predictions of small brood models using parasitoid wasps

    NARCIS (Netherlands)

    Guinnee, M.A.; Bernal, J.S.; Bezemer, T.M.; Fidgen, J.G.; Hardy, I.C.W.; Mayhew, P.J.; Mills, N.J.; West, S.A.

    2005-01-01

    Question: How is variation in offspring size (between broods) related to brood size? Hypotheses: Variance in offspring size (between broods) should decrease with increasing brood size as predicted by Charnov and colleagues' (Charnov and Downhower, 1995; Charnov et al., 1995) small brood invariant.

  2. 建立圖書館自動化系統的標準評鑑模式 Building a Standard Evaluative Model for Library Information System

    Directory of Open Access Journals (Sweden)

    Ya-ning Chen

    2002-03-01

    Full Text Available 無Library automation has been developed for 30 years nearly in Taiwan since 1973. after a serious literature review on the topic of library automation evaluation in Taiwan, only several papers have been discussed, but most for them focus on case study. This paper aims to construct a standard evaluative model for library automation system both for selection and usage. The proposed model is composed of four key components by follows: identifying the past and current trends, four facets and related content of evaluation model, evaluation principles, methods and criteria, as well as the model is exemplified into four stages. Finally, additional five issues are raised as a conclusion: cost benefits and efficiency, risk distributed, partnership relation, and librarians' skills and ability.

  3. Library Resources and Services for Faculty.

    Science.gov (United States)

    Bonn, Robert; And Others

    This pamphlet was designed to acquaint faculty at the John Jay College of Criminal Justice with general non-criminal justice services available in the college library for their own research and study. Emphasis is placed on using the reference collection of a small library and the expertise of the library staff to identify and locate information…

  4. Managing Illinois Libraries: Providing Services Customers Value.

    Science.gov (United States)

    Walzer, Norman; Stott, Karen; Sutton, Lori

    Public libraries are an important asset in virtually any size community, but especially in small towns where many social institutions are in decline or have left. Libraries increase the quality of life, help attract new residents, and support the quality of life that is essential to attracting businesses. Results from surveys of library users,…

  5. Growing small-world networks based on a modified BA model

    CERN Document Server

    Xu, Xinping; Li, Wei

    2006-01-01

    We propose a simple growing model for the evolution of small-world networks. It is introduced as a modified BA model in which all the edges connected to the new nodes are made locally to the creator and its nearest neighbors. It is found that this model can produce small-world networks with power-law degree distributions. Properties of our model, including the degree distribution, clustering, and the average path length are compared with that of the BA model. Since most real networks are both scale-free and small-world networks, our model may provide a satisfactory description for empirical characteristics of real networks.

  6. Small-world phenomena in physics: the Ising model

    Energy Technology Data Exchange (ETDEWEB)

    Gitterman, M. [Department of Physics, Bar-Ilan University, Ramat-Gan (Israel)

    2000-12-01

    The Ising system with a small fraction of random long-range interactions is the simplest example of small-world phenomena in physics. Considering the latter both in an annealed and in a quenched state we conclude that: (a) the existence of random long-range interactions leads to a phase transition in the one-dimensional case and (b) there is a minimal average number p of these interactions per site (p<1 in the annealed state, and p{approx_equal}1 in the quenched state) needed for the appearance of the phase transition. Note that the average number of these bonds, pN/2, is much smaller than the total number of bonds, N{sup 2}/2. (author)

  7. Impact of multicollinearity on small sample hydrologic regression models

    Science.gov (United States)

    Kroll, Charles N.; Song, Peter

    2013-06-01

    Often hydrologic regression models are developed with ordinary least squares (OLS) procedures. The use of OLS with highly correlated explanatory variables produces multicollinearity, which creates highly sensitive parameter estimators with inflated variances and improper model selection. It is not clear how to best address multicollinearity in hydrologic regression models. Here a Monte Carlo simulation is developed to compare four techniques to address multicollinearity: OLS, OLS with variance inflation factor screening (VIF), principal component regression (PCR), and partial least squares regression (PLS). The performance of these four techniques was observed for varying sample sizes, correlation coefficients between the explanatory variables, and model error variances consistent with hydrologic regional regression models. The negative effects of multicollinearity are magnified at smaller sample sizes, higher correlations between the variables, and larger model error variances (smaller R2). The Monte Carlo simulation indicates that if the true model is known, multicollinearity is present, and the estimation and statistical testing of regression parameters are of interest, then PCR or PLS should be employed. If the model is unknown, or if the interest is solely on model predictions, is it recommended that OLS be employed since using more complicated techniques did not produce any improvement in model performance. A leave-one-out cross-validation case study was also performed using low-streamflow data sets from the eastern United States. Results indicate that OLS with stepwise selection generally produces models across study regions with varying levels of multicollinearity that are as good as biased regression techniques such as PCR and PLS.

  8. Introducing an Information-Seeking Skill in a School Library to Students with Autism Spectrum Disorder: Using Video Modeling and Least-to-Most Prompts

    Science.gov (United States)

    Markey, Patricia T.

    2015-01-01

    This study investigated the effectiveness of a video peer modeling and least-to-most prompting intervention in the school library setting, targeting the instructional delivery of an information-literacy skill to students with Autism Spectrum Disorder (ASD). Research studies have evaluated the effectiveness of video-modeling procedures in the…

  9. Design Practice of a Library Management System for Small and Medium Military Hospitals under LAMP Environment%LAMP环境下开发部队中小型医院图书馆系统的设计实践

    Institute of Scientific and Technical Information of China (English)

    周宏宇; 任慧朋

    2015-01-01

    This paper described the application status and advantages of LAMP (Linux+ApacheHTTP+MySQL+PHP) environment. And the design and development of a library management system under LAMP environment for small and medium military hospitals was detailed. The system was constructed with the B/S (Browser/Server) architecture and compiled with PHP language. After six months of running and debugging, the Web-based library management system reflected the great advantages in the military hospital, which veriifed the feasibility of application of three-tier architecture for B/S mode in development of the library management system.%本文介绍了LAMP(Linux+ApacheHTTP+MySQL+PHP)环境的应用现状和优势,并详细介绍了在LAMP系统环境下开发部署Web方式的军队中小型医院图书管理系统的全过程。系统采用B/S构架,以PHP语言编译,经过半年的运行调试,Web方式的图书管理系统在军队医院体现出极大的优势,验证了利用三层架构的B/S模式开发医院图书管理系统的可行性。

  10. Cooperation Model and Future Development Between NGO and Libraries%NGO与图书馆的合作模式及发展方向

    Institute of Scientific and Technical Information of China (English)

    张治理

    2011-01-01

    This paper learns successful experience from NGO of developed countries, analyzes NGO' s role and issues in the process of Chinese library development, including cooperation models, NGO' s impact on library service and construction as well as some cooperation issues needed to be solved between NGO and library. On the basis of that, it proposes that the Library Society of China should play an important role in bringing NGO into library community to advance the development of Chinese libraries.%借鉴发达国家NGO的成功经验,分析NGO在中国图书馆发展过程中的状况和问题,包括NGO与图书馆的合作形式、NGO对图书馆建设与服务的影响及NGO与图书馆合作中一些亟待解决的问题。在此基础上,提出问题的解决方法:充分发挥中国图书馆学会的作用,将NGO有效地引入到图书馆事业中来,从而推动中国图书馆事业的发展。

  11. Multiscale measurement error models for aggregated small area health data.

    Science.gov (United States)

    Aregay, Mehreteab; Lawson, Andrew B; Faes, Christel; Kirby, Russell S; Carroll, Rachel; Watjou, Kevin

    2016-08-01

    Spatial data are often aggregated from a finer (smaller) to a coarser (larger) geographical level. The process of data aggregation induces a scaling effect which smoothes the variation in the data. To address the scaling problem, multiscale models that link the convolution models at different scale levels via the shared random effect have been proposed. One of the main goals in aggregated health data is to investigate the relationship between predictors and an outcome at different geographical levels. In this paper, we extend multiscale models to examine whether a predictor effect at a finer level hold true at a coarser level. To adjust for predictor uncertainty due to aggregation, we applied measurement error models in the framework of multiscale approach. To assess the benefit of using multiscale measurement error models, we compare the performance of multiscale models with and without measurement error in both real and simulated data. We found that ignoring the measurement error in multiscale models underestimates the regression coefficient, while it overestimates the variance of the spatially structured random effect. On the other hand, accounting for the measurement error in multiscale models provides a better model fit and unbiased parameter estimates.

  12. Evolution of the 'Trick' Dynamic Software Executive and Model Libraries for Reusable Flight Software Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In response to a need for cost-effective small satellite missions, Odyssey Space Research is proposing the development of a common flight software executive and a...

  13. Structure-based design of combinatorial mutagenesis libraries.

    Science.gov (United States)

    Verma, Deeptak; Grigoryan, Gevorg; Bailey-Kellogg, Chris

    2015-05-01

    The development of protein variants with improved properties (thermostability, binding affinity, catalytic activity, etc.) has greatly benefited from the application of high-throughput screens evaluating large, diverse combinatorial libraries. At the same time, since only a very limited portion of sequence space can be experimentally constructed and tested, an attractive possibility is to use computational protein design to focus libraries on a productive portion of the space. We present a general-purpose method, called "Structure-based Optimization of Combinatorial Mutagenesis" (SOCoM), which can optimize arbitrarily large combinatorial mutagenesis libraries directly based on structural energies of their constituents. SOCoM chooses both positions and substitutions, employing a combinatorial optimization framework based on library-averaged energy potentials in order to avoid explicitly modeling every variant in every possible library. In case study applications to green fluorescent protein, β-lactamase, and lipase A, SOCoM optimizes relatively small, focused libraries whose variants achieve energies comparable to or better than previous library design efforts, as well as larger libraries (previously not designable by structure-based methods) whose variants cover greater diversity while still maintaining substantially better energies than would be achieved by representative random library approaches. By allowing the creation of large-scale combinatorial libraries based on structural calculations, SOCoM promises to increase the scope of applicability of computational protein design and improve the hit rate of discovering beneficial variants. While designs presented here focus on variant stability (predicted by total energy), SOCoM can readily incorporate other structure-based assessments, such as the energy gap between alternative conformational or bound states.

  14. Academic Libraries

    Science.gov (United States)

    Library Journal, 1970

    1970-01-01

    Building data is given for the following academic libraries: (1) Rosary College, River Forest, Illinois; (2) Abilene Christian College, Abilene, Texas; (3) University of California, San Diego, La Jolla, California. (MF)

  15. Optimization of small portable hoist load-capacity model

    Science.gov (United States)

    Tang, Yuanheng; Yin, Hao; Liang, Zuotang; Xu, Cheng

    2017-04-01

    Small Portable Hoist (SPH) is needed in many special occasions; the load-capacity (LC) is one of the most important metrics. There are few researches direct related on SPH and the LC is calculated by Euler's formula in most published related literatures. Because of the SPH's unique, experimental research is carried out on the LC, an optimization of Euler's formula is got by analyzing the effects of wrap angle φ, end tension FB, and relative size of r and R. This optimization is more accurate and it deepens the understanding of the friction between wheel and the bending rope.

  16. Modeling the amide I bands of small peptides

    NARCIS (Netherlands)

    Jansen, Thomas la Cour; Dijkstra, Arend G.; Watson, Tim M.; Hirst, Jonathan D.; Knoester, Jasper

    2006-01-01

    In this paper different floating oscillator models for describing the amide I band of peptides and proteins are compared with density functional theory (DFT) calculations. Models for the variation of the frequency shifts of the oscillators and the nearest-neighbor coupling between them with respect

  17. CellLab-CTS 2015: a Python library for continuous-time stochastic cellular automaton modeling using Landlab

    Science.gov (United States)

    Tucker, G. E.; Hobley, D. E. J.; Hutton, E.; Gasparini, N. M.; Istanbulluoglu, E.; Adams, J. M.; Nudurupati, S. S.

    2015-11-01

    CellLab-CTS 2015 is a Python-language software library for creating two-dimensional, continuous-time stochastic (CTS) cellular automaton models. The model domain consists of a set of grid nodes, with each node assigned an integer state-code that represents its condition or composition. Adjacent pairs of nodes may undergo transitions to different states, according to a user-defined average transition rate. A model is created by writing a Python code that defines the possible states, the transitions, and the rates of those transitions. The code instantiates, initializes, and runs one of four object classes that represent different types of CTS model. CellLab-CTS provides the option of using either square or hexagonal grid cells. The software provides the ability to treat particular grid-node states as moving particles, and to track their position over time. Grid nodes may also be assigned user-defined properties, which the user can update after each transition through the use of a callback function. As a component of the Landlab modeling framework, CellLab-CTS models take advantage of a suite of Landlab's tools and capabilities, such as support for standardized input and output.

  18. Cloud Computing and Your Library

    Science.gov (United States)

    Mitchell, Erik T.

    2010-01-01

    One of the first big shifts in how libraries manage resources was the move from print-journal purchasing models to database-subscription and electronic-journal purchasing models. Libraries found that this transition helped them scale their resources and provide better service just by thinking a bit differently about their services. Likewise,…

  19. Cloud Computing and Your Library

    Science.gov (United States)

    Mitchell, Erik T.

    2010-01-01

    One of the first big shifts in how libraries manage resources was the move from print-journal purchasing models to database-subscription and electronic-journal purchasing models. Libraries found that this transition helped them scale their resources and provide better service just by thinking a bit differently about their services. Likewise,…

  20. Binary choices in small and large groups: A unified model

    Science.gov (United States)

    Bischi, Gian-Italo; Merlone, Ugo

    2010-02-01

    Two different ways to model the diffusion of alternative choices within a population of individuals in the presence of social externalities are known in the literature. While Galam’s model of rumors spreading considers a majority rule for interactions in several groups, Schelling considers individuals interacting in one large group, with payoff functions that describe how collective choices influence individual preferences. We incorporate these two approaches into a unified general discrete-time dynamic model for studying individual interactions in variously sized groups. We first illustrate how the two original models can be obtained as particular cases of the more general model we propose, then we show how several other situations can be analyzed. The model we propose goes beyond a theoretical exercise as it allows modeling situations which are relevant in economic and social systems. We consider also other aspects such as the propensity to switch choices and the behavioral momentum, and show how they may affect the dynamics of the whole population.

  1. Hydrological Modelling of Small Scale Processes in a Wetland Habitat

    DEFF Research Database (Denmark)

    Johansen, Ole; Jensen, Jacob Birk; Pedersen, Morten Lauge

    2009-01-01

    Numerical modelling of the hydrology in a Danish rich fen area has been conducted. By collecting various data in the field the model has been successfully calibrated and the flow paths as well as the groundwater discharge distribution have been simulated in details. The results of this work have...... shown that distributed numerical models can be applied to local scale problems and that natural springs, ditches, the geological conditions as well as the local topographic variations have a significant influence on the flow paths in the examined rich fen area....

  2. Architectural Optimization of Digital Libraries

    Science.gov (United States)

    Biser, Aileen O.

    1998-01-01

    This work investigates performance and scaling issues relevant to large scale distributed digital libraries. Presently, performance and scaling studies focus on specific implementations of production or prototype digital libraries. Although useful information is gained to aid these designers and other researchers with insights to performance and scaling issues, the broader issues relevant to very large scale distributed libraries are not addressed. Specifically, no current studies look at the extreme or worst case possibilities in digital library implementations. A survey of digital library research issues is presented. Scaling and performance issues are mentioned frequently in the digital library literature but are generally not the focus of much of the current research. In this thesis a model for a Generic Distributed Digital Library (GDDL) and nine cases of typical user activities are defined. This model is used to facilitate some basic analysis of scaling issues. Specifically, the calculation of Internet traffic generated for different configurations of the study parameters and an estimate of the future bandwidth needed for a large scale distributed digital library implementation. This analysis demonstrates the potential impact a future distributed digital library implementation would have on the Internet traffic load and raises questions concerning the architecture decisions being made for future distributed digital library designs.

  3. Small Scale Drop Tower Test for Practice Torpedo Impact Modelling

    Science.gov (United States)

    2012-06-01

    Table E3. Tensile test results for the aluminium 6061 -T6 model hull plates. 2 coupons were cut with their length parallel to the long side of the...and without stiffeners and aluminium plate without stiffeners. A qualitative comparison of the results for the three model hull forms shows that...stiffeners tend to limit the extent of the dent, that aluminium plate has a greater elastic response than that of both stiffened and unstiffened steel

  4. Evaluation model of reinforcement structures of Small mass movement

    Directory of Open Access Journals (Sweden)

    Gustavo Antonio Piazza

    2015-04-01

    Full Text Available Mass movements can be the result of elevated precipitation events and inadequate policies of land use. This study aims at diagnosing the performance of a hillside stabilization structure that suffered a landslide in the meteorological event at the Itajaí Valley in 2008, and to propose a simple method for evaluating reinforcement structures of small mass movement. The study area is located at BR–470 – km 45, near to the city limit of Gaspar and Blumenau, in Santa Catarina, South Brazil. Tests were performed to determine the infiltration rate and soil moisture, as well as a survey of the floristic composition and slope. The mass movement still takes place and the stabilization structure is compromised. The use of gabion wall and other geotechnical techniques for environmental recovery were insufficient to provide the hillside stabilization. To a greater efficiency we suggest: slope reduction; soil compaction; suitable planting species (ecologic succession; and implementation of a comprehensive drainage system.

  5. Computational approaches for efficiently modelling of small atmospheric clusters

    DEFF Research Database (Denmark)

    Elm, Jonas; Mikkelsen, Kurt Valentin

    2014-01-01

    Utilizing a comprehensive test set of 205 clusters of atmospheric relevance, we investigate how different DFT functionals (M06-2X, PW91, ωB97X-D) and basis sets (6-311++G(3df,3pd), 6-31++G(d,p), 6-31+G(d)) affect the thermal contribution to the Gibbs free energy and single point energy. Reducing...... the basis set used in the geometry and frequency calculation from 6-311++G(3df,3pd) → 6-31++G(d,p) implies a significant speed-up in computational time and only leads to small errors in the thermal contribution to the Gibbs free energy and subsequent coupled cluster single point energy calculation....

  6. Encoded library technology screening of hepatitis C virus NS4B yields a small-molecule compound series with in vitro replicon activity.

    Science.gov (United States)

    Arico-Muendel, Christopher; Zhu, Zhengrong; Dickson, Hamilton; Parks, Derek; Keicher, Jesse; Deng, Jianghe; Aquilani, Leah; Coppo, Frank; Graybill, Todd; Lind, Kenneth; Peat, Andrew; Thomson, Michael

    2015-01-01

    To identify novel antivirals to the hepatitis C virus (HCV) NS4B protein, we utilized encoded library technology (ELT), which enables purified proteins not amenable to standard biochemical screening methods to be tested against large combinatorial libraries in a short period of time. We tested NS4B against several DNA-encoded combinatorial libraries (DEL) and identified a single DEL feature that was subsequently progressed to off-DNA synthesis. The most active of the initial synthesized compounds had 50% inhibitory concentrations (IC50s) of 50 to 130 nM in a NS4B radioligand binding assay and 300 to 500 nM in an HCV replicon assay. Chemical optimization yielded compounds with potencies as low as 20 nM in an HCV genotype 1b replicon assay, 500 nM against genotype 1a, and 5 μM against genotype 2a. Through testing against other genotypes and genotype 2a-1b chimeric replicons and from resistance passage using the genotype 1b replicon, we confirmed that these compounds were acting on the proposed first transmembrane region of NS4B. A single sequence change (F98L) was identified as responsible for resistance, and it was thought to largely explain the relative lack of potency of this series against genotype 2a. Unlike other published series that appear to interact with this region, we did not observe sensitivity to amino acid substitutions at positions 94 and 105. The discovery of this novel compound series highlights ELT as a valuable approach for identifying direct-acting antivirals to nonenzymatic targets.

  7. 高校图书馆学科服务模式探讨%Discussion on Academic Library Subject Service Model

    Institute of Scientific and Technical Information of China (English)

    潘可

    2012-01-01

    Subject service is an advanced concept to run a library and a new service model for international library community.With the development of user information needs and inforamtion environment as well as the requirements of self-development for libraries,subject service is a long-term trend for academic libraries.Through the research on current subject services implemented in Hubei academic libraries,the thesis indicates that establishing a subject team is a suitable subject service model for our academic libraies.%学科服务是国际图书馆界的一种先进的办馆理念和全新服务模式。随着用户信息需求、信息环境的变化以及图书馆自身发展的要求,图书馆实行学科服务是一个长期的趋势。通过湖北省高校图书馆学科服务的调研分析,认为学科团队是适合我国高校图书馆发展现状的学科服务模式。

  8. Small Signal Model for VSC-HVDC Connected DFIG-Based Offshore Wind Farms

    Directory of Open Access Journals (Sweden)

    Kai Liao

    2014-01-01

    Full Text Available Large-scale offshore wind farms are integrated with onshore ac grids through the voltage source converter based high voltage direct current (VSC-HVDC transmission system. The impact on the stability of the ac grids will be significant. The small signal model of a wind farm connected with voltage source converter based dc transmission system is studied in this paper. A suitable model for small signal stability analysis is presented. The control system of wind generator and the HVDC system has also been modeled in this model for small signal stability analysis. The impact of the control parameters on the network stability is investigated.

  9. How to Make Small and Medium-sized Public Libraries the Symbol of "Urbanization"%中小型公共图书馆在城镇化建设中的现状及对策

    Institute of Scientific and Technical Information of China (English)

    边晓红

    2014-01-01

    The background of this paper is based on the occasion of "National Promotion of the Healthy Development of Urbanization Plan"and "National Public Librarianship in the 'Twelve -Five'plan".This paper presents the priority significance of developing small and medium -sized cities and libraries in this two plans ,indicates that with the healthy development of urbanization and public librarianship ,small and medium -sized library will become the symbol of urbanization .%本文解读了《全国促进城镇化健康发展规划》、《全国公共图书馆事业发展“十二五”规划》和重点发展中小城市与中小型图书馆的意义与目标,指出随着我国城镇化建设进程和公共图书馆事业的发展,中小型公共图书馆将成为城镇化建设的标志。

  10. From Large to Small Scales: Global Models of the ISM

    CERN Document Server

    D'Avillez, M A

    2004-01-01

    We review large scale modelling of the ISM with emphasis on the importance to include the disk-halo-disk duty cycle and to use a dynamical refinement of the grid (in regions where steep variations of density and pressure occur) for a realistic modelling of the ISM. We also discuss the necessity of convergence of the simulation results by comparing 0.625, 1.25 and 2.5 pc resolution simulations and show that a minimum grid resolution of 1.25 pc is required for quantitatively reliable results, as there is a rapid convergence for $\\Delta x \\leq 1.1$ pc.

  11. Early Tracking Behavior in Small-field Quintessence Models

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    We study several quintessence models which are exotic at Q = 0, anduse a simple constraint Q ≥ H/2π to check when they enter the tracking regime,disregarding the details of inflation. We find that it can also give strong constraintsfor V = V0Q-α, which has to enter the tracking regime after lnz ~ 10, while forthe supergravity model V = V0Q-αexp(kQ2/2), the constraint is much weaker. Forthe exponential form of inverse power-law potential V = Voexp(λ/Q), it exhibits noconstraints.

  12. Greedy Learning of Graphical Models with Small Girth

    Science.gov (United States)

    2013-01-01

    incoherence assumption to guarantee its success. In [18] Bento et al. showed that even for a large class of Ising models the incoherence conditions are not...O ( p2 + p (ξ+1) ) Bento et al. ∆ degree limited, Ising model, correlation decay Ω ( ∆2 (1−2∆ tanh θ)2 log p ) O ( p2 ) TABLE I: Performance...gradually decreases as the path distance between the corresponding nodes increase in the graph G. In [18] Bento et al. showed that learning graphical

  13. A semi-empirical library of galaxy spectra for Gaia classification based on SDSS data and PEGASE models

    CERN Document Server

    Tsalmantza, P; Kontizas, M; Bailer-Jones, C A L; Rocca-Volmerange, B; Livanou, E; Bellas-Velidis, I; Kontizas, E; Vallenari, A

    2011-01-01

    Aims:This paper is the third in a series implementing a classification system for Gaia observations of unresolved galaxies. The system makes use of template galaxy spectra in order to determine spectral classes and estimate intrinsic astrophysical parameters. In previous work we used synthetic galaxy spectra produced by PEGASE.2 code to simulate Gaia observations and to test the performance of Support Vector Machine (SVM) classifiers and parametrizers. Here we produce a semi-empirical library of galaxy spectra by fitting SDSS spectra with the previously produced synthetic libraries. We present (1) the semi-empirical library of galaxy spectra, (2) a comparison between the observed and synthetic spectra, and (3) first results of claassification and parametrization experiments with simulated Gaia spectrophotometry of this library. Methods: We use chi2-fitting to fit SDSS galaxy spectra with the synthetic library in order to construct a semi-empirical library of galaxy spectra in which (1) the real spectra are ex...

  14. Modelling the exposure to chemicals for risk assessment: a comprehensive library of multimedia and PBPK models for integration, prediction, uncertainty and sensitivity analysis - the MERLIN-Expo tool.

    Science.gov (United States)

    Ciffroy, P; Alfonso, B; Altenpohl, A; Banjac, Z; Bierkens, J; Brochot, C; Critto, A; De Wilde, T; Fait, G; Fierens, T; Garratt, J; Giubilato, E; Grange, E; Johansson, E; Radomyski, A; Reschwann, K; Suciu, N; Tanaka, T; Tediosi, A; Van Holderbeke, M; Verdonck, F

    2016-10-15

    MERLIN-Expo is a library of models that was developed in the frame of the FP7 EU project 4FUN in order to provide an integrated assessment tool for state-of-the-art exposure assessment for environment, biota and humans, allowing the detection of scientific uncertainties at each step of the exposure process. This paper describes the main features of the MERLIN-Expo tool. The main challenges in exposure modelling that MERLIN-Expo has tackled are: (i) the integration of multimedia (MM) models simulating the fate of chemicals in environmental media, and of physiologically based pharmacokinetic (PBPK) models simulating the fate of chemicals in human body. MERLIN-Expo thus allows the determination of internal effective chemical concentrations; (ii) the incorporation of a set of functionalities for uncertainty/sensitivity analysis, from screening to variance-based approaches. The availability of such tools for uncertainty and sensitivity analysis aimed to facilitate the incorporation of such issues in future decision making; (iii) the integration of human and wildlife biota targets with common fate modelling in the environment. MERLIN-Expo is composed of a library of fate models dedicated to non biological receptor media (surface waters, soils, outdoor air), biological media of concern for humans (several cultivated crops, mammals, milk, fish), as well as wildlife biota (primary producers in rivers, invertebrates, fish) and humans. These models can be linked together to create flexible scenarios relevant for both human and wildlife biota exposure. Standardized documentation for each model and training material were prepared to support an accurate use of the tool by end-users. One of the objectives of the 4FUN project was also to increase the confidence in the applicability of the MERLIN-Expo tool through targeted realistic case studies. In particular, we aimed at demonstrating the feasibility of building complex realistic exposure scenarios and the accuracy of the

  15. Microcomputers and School Libraries in the United Kingdom: Part I.

    Science.gov (United States)

    Pain-Lewins, Helen; Watson, Linda

    1990-01-01

    Discussion of the use of microcomputers in school libraries in the United Kingdom focuses on three models of school library computerization: (1) a library management-centered model, which addresses routine library operations; (2) a pupil-centered information skills model; and (3) a curriculum-centered model, which furthers pupil learning in…

  16. Stooke Small Body Shape Models V2.0

    Science.gov (United States)

    Stooke, P.

    2016-10-01

    This data set contains Philip Stooke shape models for 243 Ida, 253 Mathilde, 951 Gaspra, comet Halley, J5 Amalthea, J14 Thebe, N7 Larissa, N8 Proteus, S10 Janus, S11 Epimetheus, S16 Prometheus, and S17 Pandora, based on optical data from the NEAR, Galileo, Giotto, Vega 1, Vega 2, and Voyager missions.

  17. Stellar population synthesis models between 2.5 and 5 {\\mu}m based on the empirical IRTF stellar library

    CERN Document Server

    Röck, B; Peletier, R F; Knapen, J H; Falcón-Barroso, J

    2015-01-01

    We present the first single-burst stellar population models in the infrared wavelength range between 2.5 and 5 {\\mu}m which are exclusively based on empirical stellar spectra. Our models take as input 180 spectra from the stellar IRTF (Infrared Telescope Facility) library. Our final single-burst stellar population models are calculated based on two different sets of isochrones and various types of initial mass functions of different slopes, ages larger than 1 Gyr and metallicities between [Fe/H] = -0.70 and 0.26. They are made available online to the scientific community on the MILES web page. We analyse the behaviour of the Spitzer [3.6]-[4.5] colour calculated from our single stellar population models and find only slight dependences on both metallicity and age. When comparing to the colours of observed early-type galaxies, we find a good agreement for older, more massive galaxies that resemble a single-burst population. Younger, less massive and more metal-poor galaxies show redder colours with respect to ...

  18. Modeling Flash Floods in Small Ungaged Watersheds using Embedded GIS

    OpenAIRE

    Knocke, Ethan William

    2006-01-01

    Effective prediction of localized flash flood regions for an approaching rainfall event requires an in-depth knowledge of the land surface and stream characteristics of the forecast area. Flash Flood Guidance (FFG) is currently formulated once or twice a day at the county level by River Forecast Centers (RFC) in the U.S. using modeling systems that contain coarse, generalized land and stream characteristics and hydrologic runoff techniques that often are not calibrated for the forecast regio...

  19. America's Star Libraries

    Science.gov (United States)

    Lyons, Ray; Lance, Keith Curry

    2009-01-01

    "Library Journal"'s new national rating of public libraries, the "LJ" Index of Public Library Service, identifies 256 "star" libraries. It rates 7,115 public libraries. The top libraries in each group get five, four, or three Michelin guide-like stars. All included libraries, stars or not, can use their scores to learn from their peers and improve…

  20. America's Star Libraries

    Science.gov (United States)

    Lyons, Ray; Lance, Keith Curry

    2009-01-01

    "Library Journal"'s new national rating of public libraries, the "LJ" Index of Public Library Service, identifies 256 "star" libraries. It rates 7,115 public libraries. The top libraries in each group get five, four, or three Michelin guide-like stars. All included libraries, stars or not, can use their scores to learn from their peers and improve…

  1. Overview of KRAS-Driven Genetically Engineered Mouse Models of Non-Small Cell Lung Cancer.

    Science.gov (United States)

    Sheridan, Clare; Downward, Julian

    2015-01-01

    KRAS, the most frequently mutated oncogene in non-small cell lung cancer, has been utilized extensively to model human lung adenocarcinomas. The results from such studies have enhanced considerably an understanding of the relationship between KRAS and the development of lung cancer. Detailed in this overview are the features of various KRAS-driven genetically engineered mouse models (GEMMs) of non-small cell lung cancer, their utilization, and the potential of these models for the study of lung cancer biology.

  2. Barnes maze testing strategies with small and large rodent models.

    Science.gov (United States)

    Rosenfeld, Cheryl S; Ferguson, Sherry A

    2014-02-26

    Spatial learning and memory of laboratory rodents is often assessed via navigational ability in mazes, most popular of which are the water and dry-land (Barnes) mazes. Improved performance over sessions or trials is thought to reflect learning and memory of the escape cage/platform location. Considered less stressful than water mazes, the Barnes maze is a relatively simple design of a circular platform top with several holes equally spaced around the perimeter edge. All but one of the holes are false-bottomed or blind-ending, while one leads to an escape cage. Mildly aversive stimuli (e.g. bright overhead lights) provide motivation to locate the escape cage. Latency to locate the escape cage can be measured during the session; however, additional endpoints typically require video recording. From those video recordings, use of automated tracking software can generate a variety of endpoints that are similar to those produced in water mazes (e.g. distance traveled, velocity/speed, time spent in the correct quadrant, time spent moving/resting, and confirmation of latency). Type of search strategy (i.e. random, serial, or direct) can be categorized as well. Barnes maze construction and testing methodologies can differ for small rodents, such as mice, and large rodents, such as rats. For example, while extra-maze cues are effective for rats, smaller wild rodents may require intra-maze cues with a visual barrier around the maze. Appropriate stimuli must be identified which motivate the rodent to locate the escape cage. Both Barnes and water mazes can be time consuming as 4-7 test trials are typically required to detect improved learning and memory performance (e.g. shorter latencies or path lengths to locate the escape platform or cage) and/or differences between experimental groups. Even so, the Barnes maze is a widely employed behavioral assessment measuring spatial navigational abilities and their potential disruption by genetic, neurobehavioral manipulations, or drug

  3. COMBINATORIAL LIBRARIES

    DEFF Research Database (Denmark)

    1997-01-01

    The invention provides a method for the production of a combinatorial library of compound of general formula (I) using solid phase methodologies. The cleavage of the array of immobilised compounds of the phthalimido type from the solid support matrix is accomplished by using an array of dinucleop......The invention provides a method for the production of a combinatorial library of compound of general formula (I) using solid phase methodologies. The cleavage of the array of immobilised compounds of the phthalimido type from the solid support matrix is accomplished by using an array...... of dinucleophiles, e.g. hydrazines (hydrazinolysis) or N-hydroxylamines, whereby a combinatorial dimension is introduced in the cleavage step. The invention also provides a compound library....

  4. The Value of Academic Libraries: Library Services as a Predictor of Student Retention

    Science.gov (United States)

    Murray, Adam; Ireland, Ashley; Hackathorn, Jana

    2016-01-01

    This study examined the predictive relationship between library use by individual students and their retention status in university settings. The methodology builds on a small number of previous studies to examine library use at the individual level to determine if use of specific library services is predictive of retention for freshmen and…

  5. Handling a Small Dataset Problem in Prediction Model by employ Artificial Data Generation Approach: A Review

    Science.gov (United States)

    Lateh, Masitah Abdul; Kamilah Muda, Azah; Yusof, Zeratul Izzah Mohd; Azilah Muda, Noor; Sanusi Azmi, Mohd

    2017-09-01

    The emerging era of big data for past few years has led to large and complex data which needed faster and better decision making. However, the small dataset problems still arise in a certain area which causes analysis and decision are hard to make. In order to build a prediction model, a large sample is required as a training sample of the model. Small dataset is insufficient to produce an accurate prediction model. This paper will review an artificial data generation approach as one of the solution to solve the small dataset problem.

  6. SEMICONDUCTOR DEVICES Intrinsic stability of an HBT based on a small signal equivalent circuit model

    Science.gov (United States)

    Yanhu, Chen; Huajun, Shen; Xinyu, Liu; Huijun, Li; Hui, Xu; Ling, Li

    2010-12-01

    Intrinsic stability of the heterojunction bipolar transistor (HBT) was analyzed and discussed based on a small signal equivalent circuit model. The stability factor of the HBT device was derived based on a compact T-type small signal equivalent circuit model of the HBT. The effect of the mainly small signal model parameters of the HBT on the stability of the HBT was thoroughly examined. The discipline of parameter optimum to improve the intrinsic stability of the HBT was achieved. The theoretic analysis results of the stability were also used to explain the experimental results of the stability of the HBT and they were verified by the experimental results.

  7. From structure from motion to historical building information modeling: populating a semantic-aware library of architectural elements

    Science.gov (United States)

    Santagati, Cettina; Lo Turco, Massimiliano

    2017-01-01

    In recent years, we have witnessed a huge diffusion of building information modeling (BIM) approaches in the field of architectural design, although very little research has been undertaken to explore the value, criticalities, and advantages attributable to the application of these methodologies in the cultural heritage domain. Furthermore, the last developments in digital photogrammetry lead to the easy generation of reliable low-cost three-dimensional textured models that could be used in BIM platforms to create semantic-aware objects that could compose a specific library of historical architectural elements. In this case, the transfer between the point cloud and its corresponding parametric model is not so trivial and the level of geometrical abstraction could not be suitable with the scope of the BIM. The aim of this paper is to explore and retrace the milestone works on this crucial topic in order to identify the unsolved issues and to propose and test a unique and simple workflow practitioner centered and based on the use of the latest available solutions for point cloud managing into commercial BIM platforms.

  8. Practice & Investigation in Digital Information Service of the Small and Medium Military Hospital Libraries%军队中小型医院图书馆数字信息服务的实践与探讨

    Institute of Scientific and Technical Information of China (English)

    张优琴; 曹宏伟; 江有琴; 邱景; 彭东亮

    2011-01-01

    本文从数据库建设、依托军字一号建立信息服务栏目、利用地域优势建立馆际协作三个方面,介绍了医院图书馆开展数字信息服务的具体做法.建议军队中小型医院图书馆应加大电子文献收藏比例、注重军事医学特色数字资源建设、充分利用医院局域网络、建立因特网电子阅览室,并提出配置的馆员要适应数字信息服务模式.%This article is mainly about the digital information construction on hospital libraries in three aspects, i.e. the construction of database, No. 1 Military Medical Project and cooperation between libraries by exploiting the region advantage. It is suggested that the ratio of electronic information from the military libraries of all levels should be enhanced; special digital resources should be lay stress on construction with military characteristics, hospital local area net should made full use and internet electronic reading rooms should be found, as well as the librarians should be qualified with digital information service model.

  9. Application of microgels as polymer supports for organic synthesis: preparation of a small phthalide library, a scavenger, and a borohydride reagent.

    Science.gov (United States)

    Shimomura, Osamu; Clapham, Bruce; Spanka, Carsten; Mahajan, Suresh; Janda, Kim D

    2002-01-01

    Microgel polymers containing a series of functional groups have been prepared. These microgels were composed of cross-linked poly(styrene) and were prepared by radical polymerization in solution. The microgel polymers exhibit good solubility in an array of different organic solvents, and in addition, they can be efficiently precipitated by the addition of methanol and isolated by filtration. A nine-member phthalide library was synthesized using an aminomethyl-functionalized microgel 5. To further demonstrate the versatility of these microgel polymers, tris(2-aminoethyl)amino microgel 11 was examined as a scavenger reagent to remove unreacted isocyanate after a urea synthesis. Finally, a microgel-supported ammonium borohydride reagent 14 was successfully prepared and used as a reducing agent. Notable features of these microgels are that in all applications the progress of the reaction could be monitored by standard NMR techniques and their preparation is performed using common glassware and techniques found in all organic laboratories.

  10. Synthesis and preliminary biological evaluation of a small library of hybrid compounds based on Ugi isocyanide multicomponent reactions with a marine natural product scaffold.

    Science.gov (United States)

    Avilés, Edward; Prudhomme, Jacques; Le Roch, Karine G; Franzblau, Scott G; Chandrasena, Kevin; Mayer, Alejandro M S; Rodríguez, Abimael D

    2015-11-15

    A mixture-based combinatorial library of five Ugi adducts (4-8) incorporating known antitubercular and antimalarial pharmacophores was successfully synthesized, starting from the naturally occurring diisocyanide 3, via parallel Ugi four-center three-component reactions (U-4C-3CR). The novel α-acylamino amides obtained were evaluated for their antiinfective potential against laboratory strains of Mycobacterium tuberculosis H37Rv and chloroquine-susceptible 3D7 Plasmodium falciparum. Interestingly, compounds 4-8 displayed potent in vitro antiparasitic activity with higher cytotoxicity in comparison to their diisocyanide precursor 3, with the best compound exhibiting an IC50 value of 3.6 nM. Additionally, these natural product inspired hybrids potently inhibited in vitro thromboxane B2 (TXB2) and superoxide anion (O2(-)) generation from Escherichia coli lipopolysaccharide (LPS)-activated rat neonatal microglia, with concomitant low short-term toxicity.

  11. Constructing A Small Strain Potential for Multi-Scale Modeling

    CERN Document Server

    Mallik, A; Cheng, H P; Dufty, J W; Mallik, Aditi; Runge, Keith; Cheng, Hai-Ping; Dufty, James W.; Mallik, Aditi; Runge, Keith; Cheng, Hai-Ping; Dufty, James W.

    2005-01-01

    For problems relating to fracture, a consistent embedding of a quantum (QM) domain in its classical (CM) environment requires that the classical system should yield the same structure and elastic properties as the QM domain for states near equilibrium. It is proposed that an appropriate classical potential can be constructed using ab initio data on the equilibrium and weakly strained configurations calculated from the quantum description, rather than the more usual approach of fitting to a wide range of empirical data. The scheme is illustrated in detail for a model system, silica nanorod that has the proper stiochiometric ratio of Si:O as observed in real silica. The potential is chosen to be pairwise additive, with the same pair potential functional form as familiar phenomenological TTAM potential. Here, the parameters are determined using a genetic algorithm with force data obtained directly from a quantum calculation. The resulting potential gives excellent agreement with properties of the reference quant...

  12. Models for physics of the very small and very large

    CERN Document Server

    Buckholtz, Thomas J

    2016-01-01

    This monograph tackles three challenges. First, show math that matches known elementary particles. Second, apply the math to match other known physics data. Third, predict future physics data The math features solutions to isotropic pairs of isotropic quantum harmonic oscillators. This monograph matches some solutions to known elementary particles. Matched properties include spin and types of interactions in which the particles partake Other solutions point to possible elementary particles This monograph applies the math and the extended particle list. Results narrow gaps between physics data and theory. Results pertain to elementary particles, astrophysics, and cosmology For example, this monograph predicts properties for beyond-the-Standard-Model elementary particles, proposes descriptions of dark matter and dark energy, provides new relationships between known physics constants, includes theory that dovetails with the ratio of dark matter to ordinary matter, includes math that dovetails with the number of ...

  13. Continuous opinion model in small world directed networks

    CERN Document Server

    Gandica, Yérali; Vázquez, Gerardo J; Rojas, Sergio

    2010-01-01

    In the compromise model of continuous opinions proposed by Deffuant et al, the states of two agents in a network can start to converge if they are neighbors and if their opinions are sufficiently close to each other, below a given threshold of tolerance $\\epsilon$. In directed networks, if agent i is a neighbor of agent j, j need not be a neighbor of i. In Watts-Strogatz networks we performed simulations to find the averaged number of final opinions $$ and their distribution as a function of $\\epsilon$ and of the network structural disorder. In directed networks $$ exhibits a rich structure, being larger than in undirected networks for higher values of $\\epsilon$, and smaller for lower values of $\\epsilon$.

  14. A Library on the Robot Operating System (ROS) for Model Predictive Control implementation

    OpenAIRE

    Diaz Martinez, Rene Alexander

    2014-01-01

    Model Predictive Control is a receding horizon control technique that is based on making predictions in the future for a determined number of steps, using a model of the system to be controlled. This thesis report is centered around Model Predictive Control (MPC) and its application. In this thesis, there are two main goals: firstly, is the development of a software structure that uses the properties of Object Oriented Programming (OOP) and the Robot Operative System (ROS) to ease the use of ...

  15. The Dreyfus Model of Skill Acquisition: A Career Development Framework for Succession Planning and Management in Academic Libraries

    Science.gov (United States)

    Hall-Ellis, Sylvia D.; Grealy, Deborah S.

    2013-01-01

    Succession planning and management are critical parts of strategic planning for libraries in the twenty-first century. Making certain that the right people are in place with the prerequisite training and experience to assume leadership positions is a vital part of strategic planning and talent management in libraries that rely on teams of people…

  16. The Dreyfus Model of Skill Acquisition: A Career Development Framework for Succession Planning and Management in Academic Libraries

    Science.gov (United States)

    Hall-Ellis, Sylvia D.; Grealy, Deborah S.

    2013-01-01

    Succession planning and management are critical parts of strategic planning for libraries in the twenty-first century. Making certain that the right people are in place with the prerequisite training and experience to assume leadership positions is a vital part of strategic planning and talent management in libraries that rely on teams of people…

  17. IDENTIFICATION OF ACTIVE BACTERIAL COMMUNITIES IN A MODEL DRINKING WATER BIOFILM SYSTEM USING 16S RRNA-BASED CLONE LIBRARIES

    Science.gov (United States)

    Recent phylogenetic studies have used DNA as the target molecule for the development of environmental 16S rDNA clone libraries. As DNA may persist in the environment, DNA-based libraries cannot be used to identify metabolically active bacteria in water systems. In this study, a...

  18. Literature promotion in Public Libraries

    DEFF Research Database (Denmark)

    Kann-Christensen, Nanna; Balling, Gitte

    2011-01-01

    This article discusses a model that can be used in order to analyse notions on literature promotion in public libraries. The model integrates different issues which interact with how literature promotion is understood and thought of in public libraries. Besides cultural policy we regard the logics...... of new public management (NPM) and professional logics in the field of public libraries. Cultural policy along with the identification of underlying logics present among politicians, government officials, managers and librarians/promoters of literature, play an important part in creating an understanding...... of literature promotion in Danish libraries. Thus the basic premise for the development of the model is that cultural policy (Policy) has an important influence on notions on literature promotion and other activities in public libraries, but that cultural policy must be seen in some kind of interaction...

  19. Literature promotion in Public Libraries

    DEFF Research Database (Denmark)

    Kann-Christensen, Nanna; Balling, Gitte

    2011-01-01

    This article discusses a model that can be used in order to analyse notions on literature promotion in public libraries. The model integrates different issues which interact with how literature promotion is understood and thought of in public libraries. Besides cultural policy we regard the logics...... of new public management (NPM) and professional logics in the field of public libraries. Cultural policy along with the identification of underlying logics present among politicians, government officials, managers and librarians/promoters of literature, play an important part in creating an understanding...... of literature promotion in Danish libraries. Thus the basic premise for the development of the model is that cultural policy (Policy) has an important influence on notions on literature promotion and other activities in public libraries, but that cultural policy must be seen in some kind of interaction...

  20. Small- and large-signal modeling of InP HBTs in transferred-substrate technology

    DEFF Research Database (Denmark)

    Johansen, Tom Keinicke; Rudolph, Matthias; Jensen, Thomas

    2014-01-01

    In this paper, the small- and large-signal modeling of InP heterojunction bipolar transistors (HBTs) in transferred substrate (TS) technology is investigated. The small-signal equivalent circuit parameters for TS-HBTs in two-terminal and three-terminal configurations are determined by employing...

  1. The Accuracy of Inference in Small Samples of Dynamic Panel Data Models

    NARCIS (Netherlands)

    Bun, M.J.G.; Kiviet, J.F.

    2001-01-01

    Through Monte Carlo experiments the small sample behavior is examined of various inference techniques for dynamic panel data models when both the time-series and cross-section dimensions of the data set are small. The LSDV technique and corrected versions of it are compared with IV and GMM regarding

  2. Influence of Different Connectivity Topologies in Small World Networks Modeling Earthquakes

    Institute of Scientific and Technical Information of China (English)

    LINMin; CHENTian-Lun

    2004-01-01

    We introduce the Olami-Feder-Christensen (OFC) model on a square lattice with some "rewired" longrange connections having the properties of small world networks. We find that our model displays the power-law behavior, and connectivity topologies are very important to model's avalanche dynamical behaviors. Our model has some behaviors different from the OFC model on a small world network with "added" long-range connections in our previous work [LIN Min, ZHAO Xiao-Wei, and CHEN Tian-Lun, Commun. Theor. Phys. (Beijing, China) 41 (2004) 557.].

  3. Momentum Fractions carried by quarks and gluons in models of proton structure functions at small $x$

    CERN Document Server

    Choudhury, D K; Kalita, K

    2016-01-01

    The paper reports analysis of momentum fractions carried by quarks and gluons in models of Proton structure functions at small $x$. First, we analyze the model proposed by Lastovicka based on self-similarity sometime back. We then make a similar analysis for a second model based on the same notion which is also free from singularity in $x$ : $0models are then compared with a recent QCD based Froissart bound compatible model of proton structure function at small $x$, suggested by Block, Durand, Ha and McKay. The results are then compared with the corresponding study in perturbative and Lattice QCD.

  4. Influence of Different Connectivity Topologies in Small World Networks Modeling Earthquakes

    Institute of Scientific and Technical Information of China (English)

    LIN Min; CHEN Tian-Lun

    2004-01-01

    We introduce the Olami-Feder-Christensen (OFC) model on a squarelattice with some "rewired" long-range connections having the properties of small world networks. We find that our model displays the power-law behavior,and connectivity topologies are very important to model's avalanche dynamical behaviors. Our model has some behaviorsdifferent from the OFC model on a small world network with "added" long-range connections in our previous work [LINMin, ZHAO Xiao-Wei, and CHEN Tian-Lun, Commun. Theor. Phys. (Beijing, China) 41 (2004) 557.].

  5. Island operation - modelling of a small hydro power system

    Energy Technology Data Exchange (ETDEWEB)

    Skarp, Stefan

    2000-02-01

    Simulation is a useful tool for investigating a system behaviour. It is a way to examine operating situations without having to perform them in reality. If someone for example wants to test an operating situation where the system possibly will demolish, a computer simulation could be a both cheaper and safer way than to do the test in reality. This master thesis performs and analyses a simulation, modelling an electronic power system. The system consists of a minor hydro power station, a wood refining industry, and interconnecting power system components. In the simulation situation the system works in a so called island operation. The thesis aims at making a capacity analysis of the current system. Above all, the goal is to find restrictions in load power profile of the consumer, under given circumstances. The computer software used in simulations is Matlab and its additional program PSB (Power System Blockset). The work has been carried out in co-operation with the power supplier Skellefteaa Kraft, where the problem formulation of this master thesis was founded.

  6. Magnetic field diffusion modeling of a small enclosed firing system

    Energy Technology Data Exchange (ETDEWEB)

    Warne, L.K.; Merewether, K.O.

    1996-01-01

    Intense magnetic fields exist in the immediate vicinity of a lightning strike (and near power lines). Conducting barriers increase the rise time (and thus decrease the rise rate) interior to the barrier, but typically do not prevent penetration of the magnetic field, since the lightning current fall time may be larger than the barrier diffusion time. Thus, substantial energy is present in the interior field, although the degradation of rise rate makes it more difficult to couple into electrical circuits. This report assesses the threat posed by the diffusive magnetic field to interior components and wire loops (where voltages are induced). Analytical and numerical bounding analyses are carried out on a pill box shaped conducting barrier to develop estimates for the worst case magnetic field threats inside the system. Worst case induced voltages and energies are estimated and compared with threshold charge voltages and energies on the output capacitor of the system. Variability of these quantities with respect to design parameters are indicated. The interior magnetic field and induced voltage estimates given in this report can be used as excitations for more detailed interior and component models.

  7. Planetary Image Geometry Library

    Science.gov (United States)

    Deen, Robert C.; Pariser, Oleg

    2010-01-01

    The Planetary Image Geometry (PIG) library is a multi-mission library used for projecting images (EDRs, or Experiment Data Records) and managing their geometry for in-situ missions. A collection of models describes cameras and their articulation, allowing application programs such as mosaickers, terrain generators, and pointing correction tools to be written in a multi-mission manner, without any knowledge of parameters specific to the supported missions. Camera model objects allow transformation of image coordinates to and from view vectors in XYZ space. Pointing models, specific to each mission, describe how to orient the camera models based on telemetry or other information. Surface models describe the surface in general terms. Coordinate system objects manage the various coordinate systems involved in most missions. File objects manage access to metadata (labels, including telemetry information) in the input EDRs and RDRs (Reduced Data Records). Label models manage metadata information in output files. Site objects keep track of different locations where the spacecraft might be at a given time. Radiometry models allow correction of radiometry for an image. Mission objects contain basic mission parameters. Pointing adjustment ("nav") files allow pointing to be corrected. The object-oriented structure (C++) makes it easy to subclass just the pieces of the library that are truly mission-specific. Typically, this involves just the pointing model and coordinate systems, and parts of the file model. Once the library was developed (initially for Mars Polar Lander, MPL), adding new missions ranged from two days to a few months, resulting in significant cost savings as compared to rewriting all the application programs for each mission. Currently supported missions include Mars Pathfinder (MPF), MPL, Mars Exploration Rover (MER), Phoenix, and Mars Science Lab (MSL). Applications based on this library create the majority of operational image RDRs for those missions. A

  8. The Evolution of the Theory of Library x.0 Reasoning and Model Construction%关于Library x.0理论的演变推理与模型构建

    Institute of Scientific and Technical Information of China (English)

    路茂林

    2011-01-01

    通过对从Library 1.0到Library 2.0、Library x.0的演变过程,提出了图书馆球行关系模型,并在此基础上通过空间拓展模型对Library 1.0到Library x.0的理论作了演变推理,构建出Library 2.0理论的未来发展趋势--Library x.0,并提出了Library x.0的涵义,为Library 2.0理论的延续作了启发性的研究.

  9. Spatial and Temporal Behaviors in a Modified Evolution Model Based on Small World Network

    Institute of Scientific and Technical Information of China (English)

    ZHAO Xiao-Wei; ZHOU Li-Ming; CHEN Tian-Lun

    2004-01-01

    In this paper, we introduce a new modified evolution model on a small world network. In our model,the spatial and temporal correlations and the spatial-temporal evolve pattern of mutating nodes exhibit some particular behaviors different from those of the original BS evolution model. More importantly, these behaviors will change with φ, the density of short paths in our network.

  10. A Modified Earthquake Model of Self-Organized Criticality on Small World Networks

    Institute of Scientific and Technical Information of China (English)

    LIN Min; ZHAO Xiao-Wei; CHEN Tian-Lun

    2004-01-01

    A modified Olami Feder-Christensen model of self-organized criticality on a square lattice with the properties of small world networks has been studied.We find that our model displays power-law behavior and the exponent τ of the model depends on φ,the density of long-range connections in our network.

  11. DNA Microarray-based Ecotoxicological Biomarker Discovery in a Small Fish Model Species

    Science.gov (United States)

    This paper addresses several issues critical to use of zebrafish oligonucleotide microarrays for computational toxicology research on endocrine disrupting chemicals using small fish models, and more generally, the use of microarrays in aquatic toxicology.

  12. Testing Library Specifications by Verifying Conformance Tests

    DEFF Research Database (Denmark)

    Kiniry, Joseph Roland; Zimmerman, Daniel; Hyland, Ralph

    2012-01-01

    the Formal CTD Process (FCTD), to address this problem. Although FCTD is primarily targeted toward those who write Java libraries (or specifications for existing Java libraries) using the Java Modeling Language (JML), its techniques are broadly applicable. The key to FCTD is its novel usage of library......Formal specifications of standard libraries are necessary when statically verifying software that uses those libraries. Library specifications must be both correct, accurately reflecting library behavior, and useful, describing library behavior in sufficient detail to allow static verification...... of client programs. Specication and verification researchers regularly face the question of whether the library specications we use are correct and useful, and we have collectively provided no good answers. Over the past few years we have created and refined a software engineering process, which we call...

  13. The DSET Tool Library: A software approach to enable data exchange between climate system models

    Energy Technology Data Exchange (ETDEWEB)

    McCormick, J. [Lawrence Livermore National Lab., CA (United States)

    1994-12-01

    Climate modeling is a computationally intensive process. Until recently computers were not powerful enough to perform the complex calculations required to simulate the earth`s climate. As a result standalone programs were created that represent components of the earth`s climate (e.g., Atmospheric Circulation Model). However, recent advances in computing, including massively parallel computing, make it possible to couple the components forming a complete earth climate simulation. The ability to couple different climate model components will significantly improve our ability to predict climate accurately and reliably. Historically each major component of the coupled earth simulation is a standalone program designed independently with different coordinate systems and data representations. In order for two component models to be coupled, the data of one model must be mapped to the coordinate system of the second model. The focus of this project is to provide a general tool to facilitate the mapping of data between simulation components, with an emphasis on using object-oriented programming techniques to provide polynomial interpolation, line and area weighting, and aggregation services.

  14. Validation of Nonlinear Bipolar Transistor Model by Small-Signal Measurements

    DEFF Research Database (Denmark)

    Vidkjær, Jens; Porra, V.; Zhu, J.;

    1992-01-01

    A new method for the validity analysis of nonlinear transistor models is presented based on DC-and small-signal S-parameter measurements and realistic consideration of the measurement and de-embedding errors and singularities of the small-signal equivalent circuit. As an example, some analysis...... results for an extended Gummel Poon model are presented in the case of a UHF bipolar power transistor....

  15. Mathematical model of a novel small magnetorheological damper by using outer magnetic field

    Directory of Open Access Journals (Sweden)

    Liutian Huang

    2017-03-01

    Full Text Available In order to realize small loading and small damping, a mini Magneto-rheological fluid (MRF damper is suggested by using new method of outer coils, and its physical model is established firstly. It was found that the landing force is only 1.74∼8N, the landing force is the third-order function with the current by polynomial fitting of the experimental data, which shows a force-current model. The results of force-displacement and force-velocity indicate that it has nonlinear hysteretic damping characteristics. Based on the new mini-mode principle and the damping characteristics, an improved nonlinear dynamics model is proposed, and its parameter expressions are obtained by parameter identification and regression fitting. Model curves fit well with experimental curves, and the improved model has fully demonstrated the dynamic characteristics of the mini-MRF damper. It will provide scientific method and physical model for the small MRF damper development.

  16. Thermodynamic modeling of small scale biomass gasifiers: Development and assessment of the ''Multi-Box'' approach.

    Science.gov (United States)

    Vakalis, Stergios; Patuzzi, Francesco; Baratieri, Marco

    2016-04-01

    Modeling can be a powerful tool for designing and optimizing gasification systems. Modeling applications for small scale/fixed bed biomass gasifiers have been interesting due to their increased commercial practices. Fixed bed gasifiers are characterized by a wide range of operational conditions and are multi-zoned processes. The reactants are distributed in different phases and the products from each zone influence the following process steps and thus the composition of the final products. The present study aims to improve the conventional 'Black-Box' thermodynamic modeling by means of developing multiple intermediate 'boxes' that calculate two phase (solid-vapor) equilibriums in small scale gasifiers. Therefore the model is named ''Multi-Box''. Experimental data from a small scale gasifier have been used for the validation of the model. The returned results are significantly closer with the actual case study measurements in comparison to single-stage thermodynamic modeling.

  17. Growing Small-World Networks Based on a Modified BA Model

    Institute of Scientific and Technical Information of China (English)

    XU Xin-Ping; LIU Feng; LI Wei

    2006-01-01

    @@ We modify the (Barabási-Albert) BA model for the evolution of small-world networks. It is introduced as a modified BA model in which all the edges connected to the new node are made locally to the old node and its nearest neighbours. It is found that this model can produce small-world networks with power-law degree distributions. Properties of our model, including the degree distribution, clustering, average path length and degree correlation coefficient are compared with that of the BA model. Since most real networks are both scale free and small-world networks, our model may provide a satisfactory description for empirical characteristics of real networks.

  18. Evaluación de las bibliotecas digitales: su teoría y modelos Theory and models of assessment of digital libraries

    Directory of Open Access Journals (Sweden)

    Araceli Noguez-Ortiz

    2010-12-01

    Full Text Available Para entender cabalmente la biblioteca digital se requiere no sólo captar su concepto y caracterización, también es necesario relacionarla con los conceptos teóricos de modelo y evaluación; el estudio combinado de estas dos facetas nos lleva a comprender la combinación precisa: teoría de los modelos, modelos de evaluación y por último al modelo de evaluación de las bibliotecas digitales.To fully understand the digital library, one must grasp not only the concept and its features, but also relate it to theoretical modeling and assessment concepts. The study of these two characteristics helps provide an understanding of how modeling theory and assessment models combine to yield the specific evaluation model for digital libraries.

  19. Intelligent Libraries and Apomediators: Distinguishing between Library 3.0 and Library 2.0

    Science.gov (United States)

    Kwanya, Tom; Stilwell, Christine; Underwood, Peter G.

    2013-01-01

    Using the "point oh" naming system for developments in librarianship is attracting debate about its appropriateness, basis and syntax and the meaning and potential of Library 2.0. Now a new term, Library 3.0, has emerged. Is there is any significant difference between the two models? Using documentary analysis to explore the terms, the…

  20. Medicine's Library Lifeline.

    Science.gov (United States)

    Shipman, Jean; Homan, Michael

    2003-01-01

    Discusses how librarians in the new role of "informationist" can help doctors and researches of medical information. Describes existing models of the informationist; potential benefits of working across professional boundaries outside the library; professional requirements; and unresolved issues for the new role, including potential licensing…

  1. ECONOMETRIC MODELING OF THE DYNAMICS OF VOLUMES HYDROCARBONS OF SMALL OIL AND GAS ENTERPRISES

    Directory of Open Access Journals (Sweden)

    GORLOV A.V.

    2015-01-01

    Full Text Available In this paper investigates the principles of functioning of small oil and gas enterprises of Russia. The basic characteristics and socio-economic tasks performed by the small oil and gas enterprises. Made correlation and regression analysis, a result of which the pair correlation coefficients between the indicator of development of small oil and gas enterprises (volumes hydrocarbons and the factors that characterize the work environment of their operation; built regressions, describing the process of development of small oil and gas enterprises. With a view to forecasting the development of small oil and gas enterprises built production function of Cobb-Douglas and selected econometric model, has good predictive properties. Made predictive calculations dynamics of volumes hydrocarbons of small oil and gas enterprises on formulating scenarios for the planning period (2015-2016 years.

  2. Bayesian Predictive Inference of a Proportion Under a Twofold Small-Area Model

    Directory of Open Access Journals (Sweden)

    Nandram Balgobin

    2016-03-01

    Full Text Available We extend the twofold small-area model of Stukel and Rao (1997; 1999 to accommodate binary data. An example is the Third International Mathematics and Science Study (TIMSS, in which pass-fail data for mathematics of students from US schools (clusters are available at the third grade by regions and communities (small areas. We compare the finite population proportions of these small areas. We present a hierarchical Bayesian model in which the firststage binary responses have independent Bernoulli distributions, and each subsequent stage is modeled using a beta distribution, which is parameterized by its mean and a correlation coefficient. This twofold small-area model has an intracluster correlation at the first stage and an intercluster correlation at the second stage. The final-stage mean and all correlations are assumed to be noninformative independent random variables. We show how to infer the finite population proportion of each area. We have applied our models to synthetic TIMSS data to show that the twofold model is preferred over a onefold small-area model that ignores the clustering within areas. We further compare these models using a simulation study, which shows that the intracluster correlation is particularly important.

  3. DOLIB: Distributed Object Library

    Energy Technology Data Exchange (ETDEWEB)

    D`Azevedo, E.F.; Romine, C.H.

    1994-10-01

    This report describes the use and implementation of DOLIB (Distributed Object Library), a library of routines that emulates global or virtual shared memory on Intel multiprocessor systems. Access to a distributed global array is through explicit calls to gather and scatter. Advantages of using DOLIB include: dynamic allocation and freeing of huge (gigabyte) distributed arrays, both C and FORTRAN callable interfaces, and the ability to mix shared-memory and message-passing programming models for ease of use and optimal performance. DOLIB is independent of language and compiler extensions and requires no special operating system support. DOLIB also supports automatic caching of read-only data for high performance. The virtual shared memory support provided in DOLIB is well suited for implementing Lagrangian particle tracking techniques. We have also used DOLIB to create DONIO (Distributed Object Network I/O Library), which obtains over a 10-fold improvement in disk I/O performance on the Intel Paragon.

  4. Small-signal modelling and control of photovoltaic based water pumping system.

    Science.gov (United States)

    Ghosh, Arun; Ganesh Malla, Siva; Narayan Bhende, Chandrasekhar

    2015-07-01

    This paper studies small-signal modelling and control design for a photovoltaic (PV) based water pumping system without energy storage. First, the small-signal model is obtained and then, using this model, two proportional-integral (PI) controllers, where one controller is used to control the dc-link voltage and the other one to control the speed of induction motor, are designed to meet control goals such as settling time and peak overshoot of the closed loop responses. The loop robustness of the design is also studied. For a given set of system parameters, simulations are carried out to validate the modelling and the control design.

  5. Complex Behavior in a Selective Aging Neuron Model Based on Small World Networks

    Institute of Scientific and Technical Information of China (English)

    LUO Min-Jie; ZHANG Gui-Qing; LIU Qiu-Yu; CHEN Tian-Lun

    2008-01-01

    Complex behavior in a selective aging simple neuron model based on small world networks is investigated. The basic elements of the model are endowed with the main features of a neuron function. The structure of the selective aging neuron model is discussed. We also give some properties of the new network and find that the neuron model displays a power-law behavior. If the brain network is small world-like network, the mean avalanche size is almost the same unless the aging parameter is big enough.

  6. A methodology for linking 2D overland flow models with the sewer network model SWMM 5.1 based on dynamic link libraries.

    Science.gov (United States)

    Leandro, Jorge; Martins, Ricardo

    2016-01-01

    Pluvial flooding in urban areas is characterized by a gradually varying inundation process caused by surcharge of the sewer manholes. Therefore urban flood models need to simulate the interaction between the sewer network and the overland flow in order to accurately predict the flood inundation extents. In this work we present a methodology for linking 2D overland flow models with the storm sewer model SWMM 5. SWMM 5 is a well-known free open-source code originally developed in 1971. The latest major release saw its structure re-written in C ++ allowing it to be compiled as a command line executable or through a series of calls made to function inside a dynamic link library (DLL). The methodology developed herein is written inside the same DLL in C + +, and is able to simulate the bi-directional interaction between both models during simulation. Validation is done in a real case study with an existing urban flood coupled model. The novelty herein is that the new methodology can be added to SWMM without the need for editing SWMM's original code. Furthermore, it is directly applicable to other coupled overland flow models aiming to use SWMM 5 as the sewer network model.

  7. Mass Digitisation by Libraries: Issues concerning Organisation, Quality and Efficiency

    Directory of Open Access Journals (Sweden)

    Astrid Verheusen

    2008-03-01

    Full Text Available Ever since the world-wide web made it possible to display graphics on the Internet, libraries have been scanning their older documents and pictures to provide access to them. From the middle of the 1990s thousands of libraries of all sizes began scanning parts of their collections, provided these with metadata and made them available on the web. The emphasis in these first, rather small, digitisation projects was on experimenting with different techniques for both scanning and building interfaces for the Internet. Along the way, methods for quality assurance, project management and business models became more professional. In line with the progress made in the field of digitisation, a profound knowledge of best practices has been developed. However, this knowledge is not available for all cultural heritage institutions who want to digitise their collections. Most of the smaller institutions lack experience and, moreover, the means to digitise in an efficient way. At the same time, the larger libraries are moving towards large-scale digitisation of historical texts while Google has already digitised millions of books from several libraries around the world. Although many libraries welcome the unprecedented access to all this information, Google has also been criticized for the inferior quality of their images, the emphasis on the English language, the violation of copyright laws and the lack of attention for preservation issues. The question therefore arises: can libraries do better than Google?

  8. Construct DTPB Model by Using DEMATEL: A Study of a University Library Website

    Science.gov (United States)

    Lee, Yu-Cheng; Hsieh, Yi-Fang; Guo, Yau-Bin

    2013-01-01

    Purpose: Traditional studies on a decomposed theory of planned behavior (DTPB) analyze the relationship of variables through a structural equation model. If certain variables do not fully comply with the independent hypothesis, it is not possible to conduct proper analysis, which leads to false conclusions. To solve these problems, the aim of this…

  9. Carbon stars in the X-shooter Spectral Library. II. Comparison with models

    Science.gov (United States)

    Gonneau, A.; Lançon, A.; Trager, S. C.; Aringer, B.; Nowotny, W.; Peletier, R. F.; Prugniel, P.; Chen, Y.-P.; Lyubenova, M.

    2017-05-01

    In a previous paper, we assembled a collection of medium-resolution spectra of 35 carbon stars, covering optical and near-infrared wavelengths from 400 to 2400 nm. The sample includes stars from the Milky Way and the Magellanic Clouds, with a variety of (J-Ks) colors and pulsation properties. In the present paper, we compare these observations to a new set of high-resolution synthetic spectra, based on hydrostatic model atmospheres. We find that the broad-band colors and the molecular-band strengths measured by spectrophotometric indices match those of the models when (J-Ks) is bluer than about 1.6, while the redder stars require either additional reddening or dust emission or both. Using a grid of models to fit the full observed spectra, we estimate the most likely atmospheric parameters Teff, log (g), [Fe/H] and C/O. These parameters derived independently in the optical and near-infrared are generally consistent when (J-Ks) expected for this sample. The reddest stars ((J-Ks) > 1.6) are divided into two families, characterized by the presence or absence of an absorption feature at 1.53 μm, generally associated with HCN and C2H2. Stars from the first family begin to be more affected by circumstellar extinction. The parameters found using optical or near-infrared wavelengths are still compatible with each other, but the error bars become larger. In stars showing the 1.53 μm feature, which are all large-amplitude variables, the effects of pulsation are strong and the spectra are poorly matched with hydrostatic models. For these, atmospheric parameters could not be derived reliably, and dynamical models are needed for proper interpretation. Based on observations collected at the European Southern Observatory, Paranal, Chile, Prog. ID 084.B-0869(A/B), 085.B-0751(A/B), 189.B-0925(A/B/C/D).

  10. STUDY ON THE PERFORMANCE EVALUATION MODELS OF SMALL AND MEDIUM ENTERPRISES IN ROMANIA

    Directory of Open Access Journals (Sweden)

    Ionela-Carmen, PIRNEA

    2013-10-01

    Full Text Available In the current economic context, market by the globalization of the requirements of the European integration process, there is a growing interest in the business performance, so that they substantially improve their competitiveness in the European requirements. The paper highlights some of the results of a study conducted by the author in the doctoral program. One aim of this study was to determine the usability of business excellence models to assess the performance of small and medium enterprises in Romania. The research was conducted by the author in 2011-2012, in 173 small and medium enterprises in Romania. The research has shown that small and medium enterprises in Romania are concerned with the use of a business excellence model either Romanian or European model. Although uses a model of excellence in business, yet they meet certain criteria of the EFQM European Excellence Model.

  11. Library news

    CERN Multimedia

    CERN Library

    2010-01-01

    The CERN Library has been providing electronic access to the "Techniques de l'Ingénieur" database for the past 8 months. As a reminder, this is a multidisciplinary database of over 4000 technical and scientific articles in French, covering a broad range of topics such as mechanical engineering, safety, electronics and the environment. In a few simple steps, you can create your own account, select the types of documents you are interested in and configure your settings so as to receive alerts when articles in your field of activity are published. You can now access this resource from outside CERN using the "remote access to electronic resources" service. Further information is available here. Direct access to the database. Remote access to electronic resources. If you have any questions or comments, don't hesitate to contact us at: library.desk@cern.ch.

  12. Digital Libraries from Concept to Practice

    CERN Document Server

    Banciu, D

    2007-01-01

    The paper represents the result of research in the field of digital libraries functionalities in the context of new Grid infrastructure support. It is defined a new vector of knowledge society, informational vector - content vector. It presents a Grid European project which includes Romanian partners, and it defines on this base a digital library model which can be applied for the libraries in Romania.

  13. 知识联盟图书馆知识共享模型研究%Research on the Knowledge Sharing Model of Knowkedge Consortia Library

    Institute of Scientific and Technical Information of China (English)

    周艳

    2011-01-01

    通过对当今图书馆的知识共享现状进行分析,讨论研究知识共享的各种影响因素及策略分析,在对原有模型分析研究的基础上提出了新的模型架构,并通过对知识共享模型的研究,探讨提升知识联盟图书馆的意义。%Based on analysis the current status of knowledge sharing of the library,This article discusses the various factors affecting knowledge sharing and policy analysis,proposes new model structure based on the study of the original model.It is to explore the significance of the library to enhance knowledge alliance by the research of knowledge sharing model.

  14. Research data services in academic libraries: the essential list

    OpenAIRE

    Doñate-Cifuentes, Ana; Peset, Fernanda; Ferrer-Sapena, Antonia; García, Consol

    2016-01-01

    Study about research data services in academic library settings (America and Europe). The aim of our work is to build a list with the essential data services for the small libraries with a little budget, and describe the European situation.

  15. Does the Foreign Income Shock in a Small Open Economy DSGE Model Fit Croatian Data?

    OpenAIRE

    Arčabić, Vladimir; Globan, Tomislav; Nadoveza, Ozana; Rogić Dumančić, Lucija; Tica, Josip

    2016-01-01

    The paper compares theoretical impulse response functions from a DSGE model for a small open economy with an empirical VAR model estimated for the Croatian economy. The theoretical model fits the data well as long as monetary policy is modelled as a fixed exchange rate regime. The paper considers only a foreign output gap shock. A positive foreign shock increases domestic GDP and prices and decreases terms of trade, which is in compliance with theoretical assumptions. Interest rates behave di...

  16. Library Benchmarking

    Directory of Open Access Journals (Sweden)

    Wiji Suwarno

    2017-02-01

    Full Text Available The term benchmarking has been encountered in the implementation of total quality (TQM or in Indonesian termed holistic quality management because benchmarking is a tool to look for ideas or learn from the library. Benchmarking is a processof measuring and comparing for continuous business process of systematic and continuous measurement, the process of measuring and comparing for continuous business process of an organization to get information that can help these organization improve their performance efforts.

  17. Small World Effects in a Harmonious Unifying Hybrid Preferential Model Networks

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Small world effects in the harmonious unifying hybrid preferential model (HUHPM) networks are studied both numerically and analytically. The idea and method of the HUHPM is applied to three typical examples of unweighted BA model, weighted BBV model, and the TDE model, so-called HUHPM-BA, HUHPM-BBV and HUHPM-TDE networks. Comparing the HUHPM with current typical models above, it is found that the HUHPM networks has the smallest average path length and the biggest average clustering coefficient. The results demonstrate that the HUHPM is more suitable not only for the un-weighted models but also for the weighted models.

  18. Free/Open source integrated library management systems: comparative analysis of Koha, PHPMyLibrary and OpenBiblio

    OpenAIRE

    Vimal Kumar, V.

    2005-01-01

    Integrated library management systems can cut costs and enhance the efficiency of library services and therefore are absolutely necessary for the management of house keeping operations. But small and medium- size libraries face a difficult situation due to the high cost of commercial library management systems, foreign or Indian, available in the market. Naturally libraries without much financial resources need a cost effective way to automate their services. Free/Open source software was ...

  19. Free/Open source integrated library management systems: comparative analysis of Koha, PHPMyLibrary and OpenBiblio

    OpenAIRE

    Vimal Kumar, V.

    2005-01-01

    Integrated library management systems can cut costs and enhance the efficiency of library services and therefore are absolutely necessary for the management of house keeping operations. But small and medium- size libraries face a difficult situation due to the high cost of commercial library management systems, foreign or Indian, available in the market. Naturally libraries without much financial resources need a cost effective way to automate their services. Free/Open source software was ...

  20. The Study of Analytical Model of Library Electronic Resources Usage-A Case of Medical Electronic Resources

    OpenAIRE

    Chung-Yen Yu; Jiann-Cherng Shieh

    2014-01-01

    With the advents of internet, the importance of electronic resources is growing. Due to the increasing expensiveness of electronic resources, university libraries normally received budgets from parent institutions annually. They necessarily applied effective and systematic methods for decision making in electronic resources purchase or re-subscription. However, there are some difficulties in practices: First of all, libraries are unable to receive user records; second, the COUNTER statistics ...