A Remarkable Collection of Rare Scriptures in a Small University Library Setting

Directory of Open Access Journals (Sweden)

Teresa Cardin Ellis

2013-04-01

Full Text Available Hardin-Simmons University was given two remarkable collections of rare Bibles and a Sefer Torah with the expressed desire of the donors for the collections to be shared with students, faculty and other constituencies of the university's Richardson Library. The library has tried to fulfill this request while attempting to preserve these treasures for future generations. As small university, without a trained archivist or preservationist, we have utilized resources outside our library and contiue to pursue sources to assist us in the maintenance of these special collections while still engaging them in the educational process.

Expert Systems for Libraries at SCIL [Small Computers in Libraries]'88.

Science.gov (United States)

Kochtanek, Thomas R.; And Others

1988-01-01

Six brief papers on expert systems for libraries cover (1) a knowledge-based approach to database design; (2) getting started in expert systems; (3) using public domain software to develop a business reference system; (4) a music cataloging inquiry system; (5) linguistic analysis of reference transactions; and (6) a model of a reference librarian.…

A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.

Science.gov (United States)

Joshi, Priyanka; Chia, Sean; Habchi, Johnny; Knowles, Tuomas P J; Dobson, Christopher M; Vendruscolo, Michele

2016-03-14

The aggregation process of intrinsically disordered proteins (IDPs) has been associated with a wide range of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. Currently, however, no drug in clinical use targets IDP aggregation. To facilitate drug discovery programs in this important and challenging area, we describe a fragment-based approach of generating small-molecule libraries that target specific IDPs. The method is based on the use of molecular fragments extracted from compounds reported in the literature to inhibit of the aggregation of IDPs. These fragments are used to screen existing large generic libraries of small molecules to form smaller libraries specific for given IDPs. We illustrate this approach by describing three distinct small-molecule libraries to target, Aβ, tau, and α-synuclein, which are three IDPs implicated in Alzheimer's and Parkinson's diseases. The strategy described here offers novel opportunities for the identification of effective molecular scaffolds for drug discovery for neurodegenerative disorders and to provide insights into the mechanism of small-molecule binding to IDPs.

Development of hydrogel TentaGel shell-core beads for ultrahigh throughput solution-phase screening of encoded OBOC combinatorial small molecule libraries.

Science.gov (United States)

Baek, Hyoung Gee; Liu, Ruiwu; Lam, Kit S

2009-01-01

The one-bead one-compound (OBOC) combinatorial library method enables the rapid generation and screening of millions of discrete chemical compounds on beads. Most of the OBOC screening methods require the library compounds to remain tethered to the bead during screening process. Methods have also been developed to release library compounds from immobilized beads for in situ solution phase or "lawn" assays. However, this latter approach, while extremely powerful, is severely limited by the lack of suitable solid supports for such assays. Here, we report on the development of a novel hydrogel TentaGel shell-core (HTSC) bead in which hydrogel is grafted onto the polystyrene-based TentaGel (TG) bead as an outer shell (5-80 mum thick) via free radical surface-initiated polymerization. This novel shell-core bilayer resin enables the preparation of encoded OBOC combinatorial small molecule libraries, such that the library compounds reside on the highly hydrophilic outer layer and the coding tags reside in the polystyrene-based TG core. Using fluorescein as a model small molecule compound, we have demonstrated that fluorescein molecules that have been linked covalently to the hydrogel shell via a disulfide bond could readily diffuse out of the hydrogel layer into the bead surrounding after reduction with dithiothreitol. In contrast, under identical condition, the released fluorescein molecules remained bound to unmodified TG bead. We have prepared an encoded OBOC small molecule library on the novel shell-core beads and demonstrated that the beads can be readily decoded.

A cost-effective method for Illumina small RNA-Seq library preparation using T4 RNA ligase 1 adenylated adapters

Directory of Open Access Journals (Sweden)

Chen Yun-Ru

2012-09-01

Full Text Available Abstract Background Deep sequencing is a powerful tool for novel small RNA discovery. Illumina small RNA sequencing library preparation requires a pre-adenylated 3’ end adapter containing a 5’,5’-adenyl pyrophosphoryl moiety. In the absence of ATP, this adapter can be ligated to the 3’ hydroxyl group of small RNA, while RNA self-ligation and concatenation are repressed. Pre-adenylated adapters are one of the most essential and costly components required for library preparation, and few are commercially available. Results We demonstrate that DNA oligo with 5’ phosphate and 3’ amine groups can be enzymatically adenylated by T4 RNA ligase 1 to generate customized pre-adenylated adapters. We have constructed and sequenced a small RNA library for tomato (Solanum lycopersicum using the T4 RNA ligase 1 adenylated adapter. Conclusion We provide an efficient and low-cost method for small RNA sequencing library preparation, which takes two days to complete and costs around $20 per library. This protocol has been tested in several plant species for small RNA sequencing including sweet potato, pepper, watermelon, and cowpea, and could be readily applied to any RNA samples.

Construction of the BAC Library of Small Abalone (Haliotis diversicolor) for Gene Screening and Genome Characterization.

Science.gov (United States)

Jiang, Likun; You, Weiwei; Zhang, Xiaojun; Xu, Jian; Jiang, Yanliang; Wang, Kai; Zhao, Zixia; Chen, Baohua; Zhao, Yunfeng; Mahboob, Shahid; Al-Ghanim, Khalid A; Ke, Caihuan; Xu, Peng

2016-02-01

The small abalone (Haliotis diversicolor) is one of the most important aquaculture species in East Asia. To facilitate gene cloning and characterization, genome analysis, and genetic breeding of it, we constructed a large-insert bacterial artificial chromosome (BAC) library, which is an important genetic tool for advanced genetics and genomics research. The small abalone BAC library includes 92,610 clones with an average insert size of 120 Kb, equivalent to approximately 7.6× of the small abalone genome. We set up three-dimensional pools and super pools of 18,432 BAC clones for target gene screening using PCR method. To assess the approach, we screened 12 target genes in these 18,432 BAC clones and identified 16 positive BAC clones. Eight positive BAC clones were then sequenced and assembled with the next generation sequencing platform. The assembled contigs representing these 8 BAC clones spanned 928 Kb of the small abalone genome, providing the first batch of genome sequences for genome evaluation and characterization. The average GC content of small abalone genome was estimated as 40.33%. A total of 21 protein-coding genes, including 7 target genes, were annotated into the 8 BACs, which proved the feasibility of PCR screening approach with three-dimensional pools in small abalone BAC library. One hundred fifty microsatellite loci were also identified from the sequences for marker development in the future. The BAC library and clone pools provided valuable resources and tools for genetic breeding and conservation of H. diversicolor.

The Library Macintosh at SCIL [Small Computers in Libraries]'88.

Science.gov (United States)

Valauskas, Edward J.; And Others

1988-01-01

The first of three papers describes the role of Macintosh workstations in a library. The second paper explains why the Macintosh was selected for end-user searching in an academic library, and the third discusses advantages and disadvantages of desktop publishing for librarians. (8 references) (MES)

Cummings, Merrill, and Borrelli’s Inquiry into Small Screen Use by Academic Library Users: Timing is Everything

Directory of Open Access Journals (Sweden)

Catharine Bomhold

2018-01-01

Full Text Available A Review of: Cummings, J., Merrill, A., & Borrelli, S. (2010. The use of handheld mobile devices: Their impact and implications for library services. Library Hi Tech, (281, 22-40. https://doi.org/10.1108/07378831011026670 Abstract Objective – The authors undertook this study to understand the relatively new phenomenon of handheld computing and the use of small-screen devices among academic library users. They sought to determine if users would be inclined to search the online library catalogue on their devices and, by extension, if there would be a growing demand for small-screen compatible library services. Design – Online and paper surveys were used with both closed and open questions. Respondents included students, faculty, and staff at Washington State University (WSU. Setting – Washington State University Library, Pullman, Washington, United States of America. Subjects – The survey was open to any user of the Washington State University (Pullman Library. The 206 respondents included 126 (61.2% undergraduates, 26 (12.6% graduate or professional students, 32 (15.3% WSU employees, and 15 (7.3% faculty members. Methods – A survey was distributed both online and on paper. The online version used Surveymonkey.com and participation was solicited through various social media. It was open for three months during the Spring semester, 2007. The paper version was distributed to all library users on two days in June 2007. Eighty-four online and 122 paper responses were received. Main Results – Most of the respondents (58.4% who owned a personal digital assistant (PDA or Web-enabled cell phone (WECP indicated that they would search the library catalogue on a small-screen device. Responses to the open question “How would you use the OPAC [online public access catalogue] if it was available on a PDA or WECP?” were mixed, both positive and negative. The positive responders noted the possible time savings associated with the availability of

The JBEI quantitative metabolic modeling library (jQMM): a python library for modeling microbial metabolism

DEFF Research Database (Denmark)

Birkel, Garrett W.; Ghosh, Amit; Kumar, Vinay S.

2017-01-01

analysis, new methods for the effective use of the ever more readily available and abundant -omics data (i.e. transcriptomics, proteomics and metabolomics) are urgently needed.Results: The jQMM library presented here provides an open-source, Python-based framework for modeling internal metabolic fluxes......, it introduces the capability to use C-13 labeling experimental data to constrain comprehensive genome-scale models through a technique called two-scale C-13 Metabolic Flux Analysis (2S-C-13 MFA). In addition, the library includes a demonstration of a method that uses proteomics data to produce actionable...... insights to increase biofuel production. Finally, the use of the jQMM library is illustrated through the addition of several Jupyter notebook demonstration files that enhance reproducibility and provide the capability to be adapted to the user's specific needs.Conclusions: jQMM will facilitate the design...

Selected List of Books and Journals for the Small Medical Library

Science.gov (United States)

Brandon, Alfred N.

2012-01-01

This list of 358 books and 123 journals is intended as a selection aid for the small library of a hospital, medical society, clinic, or similar organization. Books and journals are arranged by subject, with the books followed by an author index, and the journals by an alphabetical title listing. PMID:23509428

Communicating the relevance of the library in the age of Google: Improving undergraduate research skills and information literacy though new models of library instruction

Directory of Open Access Journals (Sweden)

Jennifer Rempel

2013-12-01

ón-Aguirre & Fleming-May, 2012; tailoring library instruction to course curricula and assignments (Smith, et al., 2012; and incorporating active, student-centred learning into library instruction sessions (Abate, Gomes, & Linton, 2011. The successful implementation of these measures is ultimately dependent upon communication and collaboration among library staff, faculty, and students. Implementing major changes to library instruction can be challenging for all stakeholders; such challenges will be explored in a discussion of the implementation of a prototype library instruction model developed at Selkirk College, a small undergraduate-focused institution in British Columbia, Canada.

Cloud Computing Platform for an Online Model Library System

Directory of Open Access Journals (Sweden)

Mingang Chen

2013-01-01

Full Text Available The rapid developing of digital content industry calls for online model libraries. For the efficiency, user experience, and reliability merits of the model library, this paper designs a Web 3D model library system based on a cloud computing platform. Taking into account complex models, which cause difficulties in real-time 3D interaction, we adopt the model simplification and size adaptive adjustment methods to make the system with more efficient interaction. Meanwhile, a cloud-based architecture is developed to ensure the reliability and scalability of the system. The 3D model library system is intended to be accessible by online users with good interactive experiences. The feasibility of the solution has been tested by experiments.

Target based screening of small molecule library identifies pregnelonene, a Nrf2 agonist, as a potential radioprotector in zebrafish

International Nuclear Information System (INIS)

Joshi, Jayadev; Ghosh, Subhajit; Dimri, Manali; Shrivastava, Nitisha; Indracanti, Prem Kumar; Ray, Jharna

2014-01-01

Reactive oxygen species, cellular oxidative stress, tissue inflammation and cell death are the downstream consequences of radiation exposures which ultimately could lead to organism death. Present study aims at identifying potential targets and screening of small molecule compound library for identifying novel and effective radioprotectors. In-silco analysis of known radioprotectors revealed three main function, antioxidant, anti-inflammation and antiapoptosis. In this study, a collection of small molecules (John Hopkins Clinical Compound Library, JHCCL) were screened for these different functions using the biological activity database of NCBI with the help of in-house developed python script. Further, filtering of the JHCCL was done by searching for molecules which are known to be active against target of radiobiological significance, Nrf-2. Close observation of potential hits identified, pregnenolone, as an Nrf-2 agonist which was further evaluated for radioprotection in zebrafish model. Pregnenolone rendered significant protection (at 40 μM; added 1 hour prior to 20 Gy gamma radiation) in terms of damage manifestations (pericardial edema, microcephaly, micropthalmia, yolk sac resorption, curvature of spine, blood flow, body length, heart-beat, blood clot, roughness of skin) and survival advantage (60%) when compared to irradiated control. Further, the ability of pregnenolone to act as a neuroprotectant was also carried out using in-house developed software for assessing neuromotor functions. In comparison to radiation alone group, pregnenolone was found to possess significant neuroactive functions and diminished radiation induced neuronal impairment. Over all these results suggests that pregnenolone is an effective radioprotector which warrants further investigation for validation of its radioprotective action in higher vertebrates. Apart from that the utility of approach to screen out bioactivity data base of various chemical compound libraries for possible

Novel p38α MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library

DEFF Research Database (Denmark)

Petersen, L. K.; Blakskjær, P.; Chaikuad, A.

2016-01-01

A highly specific and potent (7 nM cellular IC50) inhibitor of p38α kinase was identified directly from a 12.6 million membered DNA-encoded small molecule library. This was achieved using the high fidelity yoctoReactor technology (yR) for preparing the DNA-encoded library, and a homogeneous...... interactions. Moreover, the crystal structure showed, that although buried in the p38α active site, the original DNA attachment point of the compound was accessible through a channel created by the distorted P-loop conformation. This study demonstrates the usability of DNA-encoded library technologies...

News from the Library: The 'long tail' Library

CERN Multimedia

CERN Library

2012-01-01

"The term 'long tail' has gained popularity in recent times as describing the retailing strategy of selling a large number of unique items with relatively small quantities sold of each usually in addition to selling fewer popular items in large quantities. The long tail was popularized by Chris Anderson, who mentioned Amazon.com, Apple and Yahoo! as examples of businesses applying this strategy." *   If we leave the business environment and move to the world of libraries, we still see this "long tail". Usually, only a small portion of a library's book collection accounts for the majority of its loans. On the other hand, there are a variety of "niche information needs" that might not be met, as libraries cannot afford to build up huge collections of documents available just-in-case. However, the networked environment of today's libraries can offer a solution. Online networks of libraries ca...

Using a Gravity Model to Predict Circulation in a Public Library System.

Science.gov (United States)

Ottensmann, John R.

1995-01-01

Describes the development of a gravity model based upon principles of spatial interaction to predict the circulation of libraries in the Indianapolis-Marion County Public Library (Indiana). The model effectively predicted past circulation figures and was tested by predicting future library circulation, particularly for a new branch library.…

E-Books and New Library Service Models: An Analysis of the Impact of E-Book Technology on Academic Libraries.

Science.gov (United States)

Jantz, Ronald

2001-01-01

Analyzes the implications of electronic book technology (e-books) on academic libraries. Discusses new business models for publishers, including self-publishing, Internet publishing, and partnerships with libraries as publishers; impact on library services, including cataloging, circulation, and digital preservation; user benefits; standards;…

Stochastic hyperfine interactions modeling library

Science.gov (United States)

Zacate, Matthew O.; Evenson, William E.

2011-04-01

The stochastic hyperfine interactions modeling library (SHIML) provides a set of routines to assist in the development and application of stochastic models of hyperfine interactions. The library provides routines written in the C programming language that (1) read a text description of a model for fluctuating hyperfine fields, (2) set up the Blume matrix, upon which the evolution operator of the system depends, and (3) find the eigenvalues and eigenvectors of the Blume matrix so that theoretical spectra of experimental techniques that measure hyperfine interactions can be calculated. The optimized vector and matrix operations of the BLAS and LAPACK libraries are utilized; however, there was a need to develop supplementary code to find an orthonormal set of (left and right) eigenvectors of complex, non-Hermitian matrices. In addition, example code is provided to illustrate the use of SHIML to generate perturbed angular correlation spectra for the special case of polycrystalline samples when anisotropy terms of higher order than A can be neglected. Program summaryProgram title: SHIML Catalogue identifier: AEIF_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEIF_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU GPL 3 No. of lines in distributed program, including test data, etc.: 8224 No. of bytes in distributed program, including test data, etc.: 312 348 Distribution format: tar.gz Programming language: C Computer: Any Operating system: LINUX, OS X RAM: Varies Classification: 7.4 External routines: TAPP [1], BLAS [2], a C-interface to BLAS [3], and LAPACK [4] Nature of problem: In condensed matter systems, hyperfine methods such as nuclear magnetic resonance (NMR), Mössbauer effect (ME), muon spin rotation (μSR), and perturbed angular correlation spectroscopy (PAC) measure electronic and magnetic structure within Angstroms of nuclear probes through the hyperfine interaction. When

Small-Town Dreamers Build $1.8-Million Community Library.

Science.gov (United States)

Fuhr, Sandra

1996-01-01

Describes how the people of Redwood Falls, Minnesota worked together to build a new public library facility in their community. Library personnel and volunteers held various fundraising activities which matched donations from a department store owner and a local grant. Discusses the architecture of the new library which includes computer…

ORIGEN-S data libraries

International Nuclear Information System (INIS)

Ryman, J.C.

1984-01-01

There are five card-image nuclear data libraries: (1) a small light element library for 253 nuclides, (2) a large light element library for 687 nuclides, (3) an actinide library for 101 nuclides, (4) a small fission product library for 461 nuclides, and (5) a large fission product library for 821 nuclides. The data for each nuclide are contained on five card-image records. The first card image contains decay data (half-life, branching fractions, recoverable energy per decay and the fraction of recoverable energy from photons), percent natural abundance, and radioactivity concentration guides. The last four card images contain cross section and (for fission product nuclides) fission yield data for four reactor types (HTGR, LWR, LMFBR, and MSBR), with one card for each reactor type. The card-image nuclear data libraries are the basic libraries for ORIGEN-S. The code can be run using these libraries directly, or it can be run from a binary data library which (prior to any cross section or other nuclear data updating) was created by running the COUPLE code to convert one or more of these card-image libraries

Research on new information service model of the contemporary library

International Nuclear Information System (INIS)

Xin Pingping; Lu Yan

2010-01-01

According to the development of the internet and multimedia technology, the information service models in the contemporary library become both of the traditional and digital information service. The libraries in each country do their best to make the voluminous information and the complex technology be High-integrated in the background management, and also make the front interface be more and more convenient to the users. The essential characteristics of the information service of the contemporary library are all-in-one and humanness. In this article, we will describe several new hot information service models of the contemporary library in detail, such as individualized service, reference service, reference service and strategic information service. (authors)

Building and Sustaining Digital Collections: Models for Libraries and Museums.

Science.gov (United States)

Council on Library and Information Resources, Washington, DC.

In February 2001, the Council on Library and Information Resources (CLIR) and the National Initiative for a Networked Cultural Heritage (NINCH) convened a meeting to discuss how museums and libraries are building digital collections and what business models are available to sustain them. A group of museum and library senior executives met with…

Planning & Urban Affairs Library Manual.

Science.gov (United States)

Knobbe, Mary L., Ed.; Lessel, Janice W., Ed.

Written especially for persons without a library degree who are operating a small urban study or planning agency library on a part-time basis. Subjects covered are: (1) library function and staff function, duties and training; (2) physical layout and equipment of library; (3) establishing and maintaining the library; (4) library administration;…

Microdissection and molecular manipulation of single chromosomes in woody fruit trees with small chromosomes using pomelo (Citrus grandis) as a model. I. Construction of single chromosomal DNA libraries.

Science.gov (United States)

Huang, D; Wu, W; Zhou, Y; Hu, Z; Lu, L

2004-05-01

Construction of single chromosomal DNA libraries by means of chromosome microdissection and microcloning will be useful for genomic research, especially for those species that have not been extensively studied genetically. Application of the technology of microdissection and microcloning to woody fruit plants has not been reported hitherto, largely due to the generally small sizes of metaphase chromosomes and the difficulty of chromosome preparation. The present study was performed to establish a method for single chromosome microdissection and microcloning in woody fruit species using pomelo as a model. The standard karyotype of a pomelo cultivar ( Citrus grandis cv. Guanxi) was established based on 20 prometaphase photomicrographs. According to the standard karyotype, chromosome 1 was identified and isolated with fine glass microneedles controlled by a micromanipulator. DNA fragments ranging from 0.3 kb to 2 kb were acquired from the isolated single chromosome 1 via two rounds of PCR mediated by Sau3A linker adaptors and then cloned into T-easy vectors to generate a DNA library of chromosome 1. Approximately 30,000 recombinant clones were obtained. Evaluation based on 108 randomly selected clones showed that the sizes of the cloned inserts varied from 0.5 kb to 1.5 kb with an average of 860 bp. Our research suggests that microdissection and microcloning of single small chromosomes in woody plants is feasible.

African Journal of Library, Archives and Information Science - Vol 12 ...

African Journals Online (AJOL)

Computer Anxiety, Phobia, Obsession and Work-Stress at the University of Ibadan: Part 2 - Evaluation of a Model. M.A. Tiamiyu, A. Ajayi, W.M. Olatokun. Resource Mobilisation for Library and Information Services Development in Africa. Elizabeth Kiondo. Moving a Small Library in an African Setting. Adriaan Swanepoel ...

Damsel: A Data Model Storage Library for Exascale Science

Energy Technology Data Exchange (ETDEWEB)

Choudhary, Alok [Northwestern Univ., Evanston, IL (United States); Liao, Wei-keng [Northwestern Univ., Evanston, IL (United States)

2014-07-11

Computational science applications have been described as having one of seven motifs (the “seven dwarfs”), each having a particular pattern of computation and communication. From a storage and I/O perspective, these applications can also be grouped into a number of data model motifs describing the way data is organized and accessed during simulation, analysis, and visualization. Major storage data models developed in the 1990s, such as Network Common Data Format (netCDF) and Hierarchical Data Format (HDF) projects, created support for more complex data models. Development of both netCDF and HDF5 was influenced by multi-dimensional dataset storage requirements, but their access models and formats were designed with sequential storage in mind (e.g., a POSIX I/O model). Although these and other high-level I/O libraries have had a beneficial impact on large parallel applications, they do not always attain a high percentage of peak I/O performance due to fundamental design limitations, and they do not address the full range of current and future computational science data models. The goal of this project is to enable exascale computational science applications to interact conveniently and efficiently with storage through abstractions that match their data models. The project consists of three major activities: (1) identifying major data model motifs in computational science applications and developing representative benchmarks; (2) developing a data model storage library, called Damsel, that supports these motifs, provides efficient storage data layouts, incorporates optimizations to enable exascale operation, and is tolerant to failures; and (3) productizing Damsel and working with computational scientists to encourage adoption of this library by the scientific community. The product of this project, Damsel library, is openly available for download from http://cucis.ece.northwestern.edu/projects/DAMSEL. Several case studies and application programming interface

A Usability Evaluation Model for Academic Library Websites: Efficiency, Effectiveness and Learnability

Directory of Open Access Journals (Sweden)

Soohyung Joo

2011-12-01

Full Text Available Purpose – This paper aimed to develop a usability evaluation model and associated survey tool in the context of academic libraries. This study not only proposed a usability evaluation model but also a practical survey tool tailored to academic library websites. Design/methodology – A usability evaluation model has been developed for academic library websites based on literature review and expert consultation. Then, the authors verified the reliability and validity of the usability evaluation model empirically using the survey data from actual users. Statistical analysis, such as descriptive statistics, internal consistency test, and a factor analysis, were applied to ensure both the reliability and validity of the usability evaluation tool. Findings – From the document analysis and expert consultation, this study identified eighteen measurement items to survey the three constructs of the usability, effectiveness, efficiency, and learnability, in academic library websites. The evaluation tool was then validated with regard to data distribution, reliability, and validity. The empirical examination based on 147 actual user responses proved the survey evaluation tool suggested herein is acceptable in assessing academic library website usability. Originality/Value – This research is one of the few studies to engender a practical survey tool in evaluating library website usability. The usability model and corresponding survey tool would be useful for librarians and library administrators in academic libraries who plan to conduct a usability evaluation involving large sample.

A standard library for modeling satellite orbits on a microcomputer

Science.gov (United States)

Beutel, Kenneth L.

1988-03-01

Introductory students of astrodynamics and the space environment are required to have a fundamental understanding of the kinematic behavior of satellite orbits. This thesis develops a standard library that contains the basic formulas for modeling earth orbiting satellites. This library is used as a basis for implementing a satellite motion simulator that can be used to demonstrate orbital phenomena in the classroom. Surveyed are the equations of orbital elements, coordinate systems and analytic formulas, which are made into a standard method for modeling earth orbiting satellites. The standard library is written in the C programming language and is designed to be highly portable between a variety of computer environments. The simulation draws heavily on the standards established by the library to produce a graphics-based orbit simulation program written for the Apple Macintosh computer. The simulation demonstrates the utility of the standard library functions but, because of its extensive use of the Macintosh user interface, is not portable to other operating systems.

Analysing and Navigating Natural Products Space for Generating Small, Diverse, But Representative Chemical Libraries.

Science.gov (United States)

O'Hagan, Steve; Kell, Douglas B

2018-01-01

Armed with the digital availability of two natural products libraries, amounting to some 195 885 molecular entities, we ask the question of how we can best sample from them to maximize their "representativeness" in smaller and more usable libraries of 96, 384, 1152, and 1920 molecules. The term "representativeness" is intended to include diversity, but for numerical reasons (and the likelihood of being able to perform a QSAR) it is necessary to focus on areas of chemical space that are more highly populated. Encoding chemical structures as fingerprints using the RDKit "patterned" algorithm, we first assess the granularity of the natural products space using a simple clustering algorithm, showing that there are major regions of "denseness" but also a great many very sparsely populated areas. We then apply a "hybrid" hierarchical K-means clustering algorithm to the data to produce more statistically robust clusters from which representative and appropriate numbers of samples may be chosen. There is necessarily again a trade-off between cluster size and cluster number, but within these constraints, libraries containing 384 or 1152 molecules can be found that come from clusters that represent some 18 and 30% of the whole chemical space, with cluster sizes of, respectively, 50 and 27 or above, just about sufficient to perform a QSAR. By using the online availability of molecules via the Molport system (www.molport.com), we are also able to construct (and, for the first time, provide the contents of) a small virtual library of available molecules that provided effective coverage of the chemical space described. Consistent with this, the average molecular similarities of the contents of the libraries developed is considerably smaller than is that of the original libraries. The suggested libraries may have use in molecular or phenotypic screening, including for determining possible transporter substrates. © 2017 The Authors. Biotechnology Journal Published by Wiley

SLHAplus: A library for implementing extensions of the standard model

Science.gov (United States)

Bélanger, G.; Christensen, Neil D.; Pukhov, A.; Semenov, A.

2011-03-01

We provide a library to facilitate the implementation of new models in codes such as matrix element and event generators or codes for computing dark matter observables. The library contains an SLHA reader routine as well as diagonalisation routines. This library is available in CalcHEP and micrOMEGAs. The implementation of models based on this library is supported by LanHEP and FeynRules. Program summaryProgram title: SLHAplus_1.3 Catalogue identifier: AEHX_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEHX_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 6283 No. of bytes in distributed program, including test data, etc.: 52 119 Distribution format: tar.gz Programming language: C Computer: IBM PC, MAC Operating system: UNIX (Linux, Darwin, Cygwin) RAM: 2000 MB Classification: 11.1 Nature of problem: Implementation of extensions of the standard model in matrix element and event generators and codes for dark matter observables. Solution method: For generic extensions of the standard model we provide routines for reading files that adopt the standard format of the SUSY Les Houches Accord (SLHA) file. The procedure has been generalized to take into account an arbitrary number of blocks so that the reader can be used in generic models including non-supersymmetric ones. The library also contains routines to diagonalize real and complex mass matrices with either unitary or bi-unitary transformations as well as routines for evaluating the running strong coupling constant, running quark masses and effective quark masses. Running time: 0.001 sec

Damsel: A Data Model Storage Library for Exascale Science

Energy Technology Data Exchange (ETDEWEB)

Koziol, Quincey [The HDF Group, Champaign, IL (United States)

2014-11-26

The goal of this project is to enable exascale computational science applications to interact conveniently and efficiently with storage through abstractions that match their data models. We will accomplish this through three major activities: (1) identifying major data model motifs in computational science applications and developing representative benchmarks; (2) developing a data model storage library, called Damsel, that supports these motifs, provides efficient storage data layouts, incorporates optimizations to enable exascale operation, and is tolerant to failures; and (3) productizing Damsel and working with computational scientists to encourage adoption of this library by the scientific community.

Damsel - A Data Model Storage Library for Exascale Science

Energy Technology Data Exchange (ETDEWEB)

Samatova, Nagiza F

2014-07-18

The goal of this project is to enable exascale computational science applications to interact conveniently and efficiently with storage through abstractions that match their data models. We will accomplish this through three major activities: (1) identifying major data model motifs in computational science applications and developing representative benchmarks; (2) developing a data model storage library, called Damsel, that supports these motifs, provides efficient storage data layouts, incorporates optimizations to enable exascale operation, and is tolerant to failures; and (3) productizing Damsel and working with computational scientists to encourage adoption of this library by the scientific community.

Designing Public Library Websites for Teens: A Conceptual Model

Science.gov (United States)

Naughton, Robin Amanda

2012-01-01

The main goal of this research study was to develop a conceptual model for the design of public library websites for teens (TLWs) that would enable designers and librarians to create library websites that better suit teens' information needs and practices. It bridges a gap in the research literature between user interface design in human-computer…

Exact diagonalization library for quantum electron models

Science.gov (United States)

Iskakov, Sergei; Danilov, Michael

2018-04-01

We present an exact diagonalization C++ template library (EDLib) for solving quantum electron models, including the single-band finite Hubbard cluster and the multi-orbital impurity Anderson model. The observables that can be computed using EDLib are single particle Green's functions and spin-spin correlation functions. This code provides three different types of Hamiltonian matrix storage that can be chosen based on the model.

Engineering modelling. A contribution to the CommonKADS library

Energy Technology Data Exchange (ETDEWEB)

Top, J.L.; Akkermans, J.M.

1993-12-01

Generic knowledge components and models for the task of in particular engineering modelling are presented.It is intended as a contribution to the CommonKADS library. In the first chapter an executive summary is provided. Next, the Conceptual Modelling Language (CML) definitions of the various generic library components are given. In the following two chapters the underlying theory is developed. First, a task-oriented analysis is made, based upon the similarities between modelling and design tasks. Second, an ontological analysis is given, which shows that ontology differentiation constitutes an important problem-solving method (PSM) for engineering modelling, on a par with task-decomposition PSMs. Finally, three different modelling applications, based on existing knowledgeable systems, are analyzed, which analysis illustrates and provides data points for the discussed generic components and models for modelling. 50 figs., 77 refs.

Linking Formal and Informal Science Education: A Successful Model using Libraries, Volunteers and NASA Resources

Science.gov (United States)

Race, M. S.; Lafayette Library; Learning Center Foundation (Lllcf)

2011-12-01

In these times of budget cuts, tight school schedules, and limited opportunities for student field trips and teacher professional development, it is especially difficult to expose elementary and middle school students to the latest STEM information-particularly in the space sciences. Using our library as a facilitator and catalyst, we built a volunteer-based, multi-faceted, curriculum-linked program for students and teachers in local middle schools (Grade 8) and showcased new astronomical and planetary science information using mainly NASA resources and volunteer effort. The project began with the idea of bringing free NASA photo exhibits (FETTU) to the Lafayette and Antioch Libraries for public display. Subsequently, the effort expanded by adding layers of activities that brought space and science information to teachers, students and the pubic at 5 libraries and schools in the 2 cities, one of which serves a diverse, underserved community. Overall, the effort (supported by a pilot grant from the Bechtel Foundation) included school and library based teacher workshops with resource materials; travelling space museum visits with hands-on activities (Chabot-to-Go); separate powerpoint presentations for students and adults at the library; and concurrent ancillary space-related themes for young children's programs at the library. This pilot project, based largely on the use of free government resources and online materials, demonstrated that volunteer-based, standards-linked STEM efforts can enhance curriculum at the middle school, with libraries serving a special role. Using this model, we subsequently also obtained a small NASA-Space Grant award to bring star parties and hand-on science activities to three libraries this Fall, linking with numerous Grade 5 teachers and students in two additional underserved areas of our county. It's not necessary to reinvent the wheel, you just collect the pieces and build on what you already have.

THE REGRESSION MODEL OF IRAN LIBRARIES ORGANIZATIONAL CLIMATE

OpenAIRE

Jahani, Mohammad Ali; Yaminfirooz, Mousa; Siamian, Hasan

2015-01-01

Background: The purpose of this study was to drawing a regression model of organizational climate of central libraries of Iran?s universities. Methods: This study is an applied research. The statistical population of this study consisted of 96 employees of the central libraries of Iran?s public universities selected among the 117 universities affiliated to the Ministry of Health by Stratified Sampling method (510 people). Climate Qual localized questionnaire was used as research tools. For pr...

The Value of Academic Libraries: Library Services as a Predictor of Student Retention

Science.gov (United States)

Murray, Adam; Ireland, Ashley; Hackathorn, Jana

2016-01-01

This study examined the predictive relationship between library use by individual students and their retention status in university settings. The methodology builds on a small number of previous studies to examine library use at the individual level to determine if use of specific library services is predictive of retention for freshmen and…

Predicting Antitumor Activity of Peptides by Consensus of Regression Models Trained on a Small Data Sample

Directory of Open Access Journals (Sweden)

Ivanka Jerić

2011-11-01

Full Text Available Predicting antitumor activity of compounds using regression models trained on a small number of compounds with measured biological activity is an ill-posed inverse problem. Yet, it occurs very often within the academic community. To counteract, up to some extent, overfitting problems caused by a small training data, we propose to use consensus of six regression models for prediction of biological activity of virtual library of compounds. The QSAR descriptors of 22 compounds related to the opioid growth factor (OGF, Tyr-Gly-Gly-Phe-Met with known antitumor activity were used to train regression models: the feed-forward artificial neural network, the k-nearest neighbor, sparseness constrained linear regression, the linear and nonlinear (with polynomial and Gaussian kernel support vector machine. Regression models were applied on a virtual library of 429 compounds that resulted in six lists with candidate compounds ranked by predicted antitumor activity. The highly ranked candidate compounds were synthesized, characterized and tested for an antiproliferative activity. Some of prepared peptides showed more pronounced activity compared with the native OGF; however, they were less active than highly ranked compounds selected previously by the radial basis function support vector machine (RBF SVM regression model. The ill-posedness of the related inverse problem causes unstable behavior of trained regression models on test data. These results point to high complexity of prediction based on the regression models trained on a small data sample.

Landlab: an Open-Source Python Library for Modeling Earth Surface Dynamics

Science.gov (United States)

Gasparini, N. M.; Adams, J. M.; Hobley, D. E. J.; Hutton, E.; Nudurupati, S. S.; Istanbulluoglu, E.; Tucker, G. E.

2016-12-01

Landlab is an open-source Python modeling library that enables users to easily build unique models to explore earth surface dynamics. The Landlab library provides a number of tools and functionalities that are common to many earth surface models, thus eliminating the need for a user to recode fundamental model elements each time she explores a new problem. For example, Landlab provides a gridding engine so that a user can build a uniform or nonuniform grid in one line of code. The library has tools for setting boundary conditions, adding data to a grid, and performing basic operations on the data, such as calculating gradients and curvature. The library also includes a number of process components, which are numerical implementations of physical processes. To create a model, a user creates a grid and couples together process components that act on grid variables. The current library has components for modeling a diverse range of processes, from overland flow generation to bedrock river incision, from soil wetting and drying to vegetation growth, succession and death. The code is freely available for download (https://github.com/landlab/landlab) or can be installed as a Python package. Landlab models can also be built and run on Hydroshare (www.hydroshare.org), an online collaborative environment for sharing hydrologic data, models, and code. Tutorials illustrating a wide range of Landlab capabilities such as building a grid, setting boundary conditions, reading in data, plotting, using components and building models are also available (https://github.com/landlab/tutorials). The code is also comprehensively documented both online and natively in Python. In this presentation, we illustrate the diverse capabilities of Landlab. We highlight existing functionality by illustrating outcomes from a range of models built with Landlab - including applications that explore landscape evolution and ecohydrology. Finally, we describe the range of resources available for new

ModFossa: A library for modeling ion channels using Python.

Science.gov (United States)

Ferneyhough, Gareth B; Thibealut, Corey M; Dascalu, Sergiu M; Harris, Frederick C

2016-06-01

The creation and simulation of ion channel models using continuous-time Markov processes is a powerful and well-used tool in the field of electrophysiology and ion channel research. While several software packages exist for the purpose of ion channel modeling, most are GUI based, and none are available as a Python library. In an attempt to provide an easy-to-use, yet powerful Markov model-based ion channel simulator, we have developed ModFossa, a Python library supporting easy model creation and stimulus definition, complete with a fast numerical solver, and attractive vector graphics plotting.

Microcomputers in the Anesthesia Library.

Science.gov (United States)

Wright, A. J.

The combination of computer technology and library operation is helping to alleviate such library problems as escalating costs, increasing collection size, deteriorating materials, unwieldy arrangement schemes, poor subject control, and the acquisition and processing of large numbers of rarely used documents. Small special libraries such as…

THE REGRESSION MODEL OF IRAN LIBRARIES ORGANIZATIONAL CLIMATE.

Science.gov (United States)

Jahani, Mohammad Ali; Yaminfirooz, Mousa; Siamian, Hasan

2015-10-01

The purpose of this study was to drawing a regression model of organizational climate of central libraries of Iran's universities. This study is an applied research. The statistical population of this study consisted of 96 employees of the central libraries of Iran's public universities selected among the 117 universities affiliated to the Ministry of Health by Stratified Sampling method (510 people). Climate Qual localized questionnaire was used as research tools. For predicting the organizational climate pattern of the libraries is used from the multivariate linear regression and track diagram. of the 9 variables affecting organizational climate, 5 variables of innovation, teamwork, customer service, psychological safety and deep diversity play a major role in prediction of the organizational climate of Iran's libraries. The results also indicate that each of these variables with different coefficient have the power to predict organizational climate but the climate score of psychological safety (0.94) plays a very crucial role in predicting the organizational climate. Track diagram showed that five variables of teamwork, customer service, psychological safety, deep diversity and innovation directly effects on the organizational climate variable that contribution of the team work from this influence is more than any other variables. Of the indicator of the organizational climate of climateQual, the contribution of the team work from this influence is more than any other variables that reinforcement of teamwork in academic libraries can be more effective in improving the organizational climate of this type libraries.

Libraries Today, Libraries Tomorrow: Contemporary Library Practices and the Role of Library Space in the L

Directory of Open Access Journals (Sweden)

Ana Vogrinčič Čepič

2013-09-01

Full Text Available ABSTRACTPurpose: The article uses sociological concepts in order to rethink the changes in library practices. Contemporary trends are discussed with regard to the changing nature of working habits, referring mostly to the new technology, and the (emergence of the third space phenomenon. The author does not regard libraries only as concrete public service institutions, but rather as complex cultural forms, taking in consideration wider social context with a stress on users’ practices in relation to space.Methodology/approach: The article is based on the (self- observation of the public library use, and on the (discourse analysis of internal library documents (i.e. annual reports and plans and secondary sociological literature. As such, the cultural form approach represents a classic method of sociology of culture.Results: The study of relevant material in combination with direct personal experiences reveals socio-structural causes for the change of users’ needs and habits, and points at the difficulty of spatial redefinition of libraries as well as at the power of the discourse.Research limitations: The article is limited to an observation of users’ practices in some of the public libraries in Ljubljana and examines only a small number of annual reports – the discoveries are then further debated from the sociological perspective.Originality/practical implications: The article offers sociological insight in the current issues of the library science and tries to suggest a wider explanation that could answer some of the challenges of the contemporary librarianship.

End-user satisfaction analysis on library management system unnes using technology acceptance model towards national standard of integrated library

Science.gov (United States)

Hardyanto, W.; Purwinarko, A.; Adhi, M. A.

2018-03-01

The library which is the gate of the University should be supported by the existence of an adequate information system, to provide excellent service and optimal to every user. Library management system that has been in existence since 2009 needs to be re-evaluated so that the system can meet the needs of both operator and Unnes user in particular, and users from outside Unnes in general. This study aims to evaluate and improve the existing library management system to produce a system that is accountable and able to meet the needs of end users, as well as produce a library management system that is integrated Unnes. Research is directed to produce evaluation report with Technology Acceptance Model (TAM) approach and library management system integrated with the national standard.

Technology for small and one-person libraries a LITA guide

CERN Document Server

Erlandson, Rene J

2013-01-01

Written for librarians, library staff, and administrators at libraries serving populations of 15,000 or less, this LITA guide shows how to successfully develop, implement, sustain, and grow technology initiatives.

SearchSmallRNA: a graphical interface tool for the assemblage of viral genomes using small RNA libraries data.

Science.gov (United States)

de Andrade, Roberto R S; Vaslin, Maite F S

2014-03-07

Next-generation parallel sequencing (NGS) allows the identification of viral pathogens by sequencing the small RNAs of infected hosts. Thus, viral genomes may be assembled from host immune response products without prior virus enrichment, amplification or purification. However, mapping of the vast information obtained presents a bioinformatics challenge. In order to by pass the need of line command and basic bioinformatics knowledge, we develop a mapping software with a graphical interface to the assemblage of viral genomes from small RNA dataset obtained by NGS. SearchSmallRNA was developed in JAVA language version 7 using NetBeans IDE 7.1 software. The program also allows the analysis of the viral small interfering RNAs (vsRNAs) profile; providing an overview of the size distribution and other features of the vsRNAs produced in infected cells. The program performs comparisons between each read sequenced present in a library and a chosen reference genome. Reads showing Hamming distances smaller or equal to an allowed mismatched will be selected as positives and used to the assemblage of a long nucleotide genome sequence. In order to validate the software, distinct analysis using NGS dataset obtained from HIV and two plant viruses were used to reconstruct viral whole genomes. SearchSmallRNA program was able to reconstructed viral genomes using NGS of small RNA dataset with high degree of reliability so it will be a valuable tool for viruses sequencing and discovery. It is accessible and free to all research communities and has the advantage to have an easy-to-use graphical interface. SearchSmallRNA was written in Java and is freely available at http://www.microbiologia.ufrj.br/ssrna/.

Library Web Site Administration: A Strategic Planning Model For the Smaller Academic Library

Science.gov (United States)

Ryan, Susan M.

2003-01-01

Strategic planning provides a useful structure for creating and implementing library web sites. The planned integration of a library's web site into its mission and objectives ensures that the library's community of users will consider the web site one of the most important information tools the library offers.

A New Model and Its Implementation of Academic Resources Services for Academic Libraries

Directory of Open Access Journals (Sweden)

Yu-Ting Chiang

2006-12-01

Full Text Available Internet has become one of the important channels for retrieval of academic resources in the recent years. The roles and service models of academic libraries has been changed accordingly. Most academic libraries have been providing subject directory (subject gateway for users to browse the highly selected academic resources. On the contrary, few academic libraries managed to provide academic resources for user to retrieve. This article proposes a new model which the libraries will cooperate with search engine providers to support the full-text retrieval for academic resources in a low cost. We discuss the design and implementation of “NTU Scholars Gateway” based on the new model. In addition, the functionalities and future development of NTU Scholars Gateway are discussedas well. [Article content in Chinese

Public library – a lifelong learning opportunity. Activities for adults in the Tolmin public library

Directory of Open Access Journals (Sweden)

Jožica Štendler

2010-12-01

Full Text Available The Libraries Act (2001 steered the development of general library services towards organising lifelong learning activities, fostering reading culture and organising cultural events. Smaller libraries in particular strive in their local environments to become information-education centres and meeting places. The paper presents the activities through which the Ciril Kosmač Library in Tolmin attempts to satisfy the intellectual and cultural needs of its adult users. The example of a small library shows that the cultural mission and educational function are directly linked and intertwined with the social role of libraries in the lives of individuals and the local community.

The Arizona Universities Library Consortium patron-driven e-book model

Directory of Open Access Journals (Sweden)

Jeanne Richardson

2013-03-01

Full Text Available Building on Arizona State University's patron-driven acquisitions (PDA initiative in 2009, the Arizona Universities Library Consortium, in partnership with the Ingram Content Group, created a cooperative patron-driven model to acquire electronic books (e-books. The model provides the opportunity for faculty and students at the universities governed by the Arizona Board of Regents (ABOR to access a core of e-books made accessible through resource discovery services and online catalogs. These books are available for significantly less than a single ABOR university would expend for the same materials. The patron-driven model described is one of many evolving models in digital scholarship, and, although the Arizona Universities Library Consortium reports a successful experience, patron-driven models pose questions to stakeholders in the academic publishing industry.

Differential representation of sunflower ESTs in enriched organ-specific cDNA libraries in a small scale sequencing project

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Heinz Ruth A

2003-09-01

Full Text Available Abstract Background Subtractive hybridization methods are valuable tools for identifying differentially regulated genes in a given tissue avoiding redundant sequencing of clones representing the same expressed genes, maximizing detection of low abundant transcripts and thus, affecting the efficiency and cost effectiveness of small scale cDNA sequencing projects aimed to the specific identification of useful genes for breeding purposes. The objective of this work is to evaluate alternative strategies to high-throughput sequencing projects for the identification of novel genes differentially expressed in sunflower as a source of organ-specific genetic markers that can be functionally associated to important traits. Results Differential organ-specific ESTs were generated from leaf, stem, root and flower bud at two developmental stages (R1 and R4. The use of different sources of RNA as tester and driver cDNA for the construction of differential libraries was evaluated as a tool for detection of rare or low abundant transcripts. Organ-specificity ranged from 75 to 100% of non-redundant sequences in the different cDNA libraries. Sequence redundancy varied according to the target and driver cDNA used in each case. The R4 flower cDNA library was the less redundant library with 62% of unique sequences. Out of a total of 919 sequences that were edited and annotated, 318 were non-redundant sequences. Comparison against sequences in public databases showed that 60% of non-redundant sequences showed significant similarity to known sequences. The number of predicted novel genes varied among the different cDNA libraries, ranging from 56% in the R4 flower to 16 % in the R1 flower bud library. Comparison with sunflower ESTs on public databases showed that 197 of non-redundant sequences (60% did not exhibit significant similarity to previously reported sunflower ESTs. This approach helped to successfully isolate a significant number of new reported sequences

South Dakota State University's Library: A History. Hilton M. Briggs Library Occasional Paper Number 1.

Science.gov (United States)

Brown, Philip

Tracing the history of South Dakota State University's Hilton M. Briggs Library over the past 102 years, this occasional paper describes the development of what is now the largest library (over 1.1 million total pieces) in the South Dakota Library Network from its inception as part of a small land grant college. Administrative eras are reviewed,…

User-focused, User-led: Space Assessment to Transform a Small Academic Library

Directory of Open Access Journals (Sweden)

Christina Hillman

2017-12-01

Full Text Available Abstract Objective – By collecting and analyzing evidence from three data points, researchers sought to understand how library spaces are used. Researchers have used results for evidence based decision making regarding physical library spaces. Methods – Undergraduate researchers, sociology faculty, and librarians used mixed-methods to triangulate findings. Seating sweeps were used to map patrons’ activities in the library. Student-led focus groups discussed patterns of library use, impressions of facilities, and library features and services. The final step included a campus survey developed from seating sweeps and focus group findings. Results – Seating sweeps showed consistent use of the library's main level Learning Commons and upper level quiet spaces; the library’s multipurpose lower level is under-utilized. Students use the main level of the library for collaborative learning, socializing, reading, and computer use. Students use the upper level for quiet study and group work in study rooms. Focus group findings found library use is task-specific. For example, a student may work with classmates on a project using the main level Learning Commons during the day, and then come back at night to use the quiet floor for test preparation. Survey responses highlighted areas in which the library is deficient. For example, respondents cited crowdedness, noise levels, and temperature concerns. Conclusion – These data offer empirical evidence for library space needs. Some data aligns with previous space studies conducted at this library: access to power outlets, lighting, noise, and an outdated environment. Evidence also supports anecdotal concerns of crowding, graduate students lacking designated study space, and the need for quiet study space away from group study space.

Statistical molecular design of balanced compound libraries for QSAR modeling.

Science.gov (United States)

Linusson, A; Elofsson, M; Andersson, I E; Dahlgren, M K

2010-01-01

A fundamental step in preclinical drug development is the computation of quantitative structure-activity relationship (QSAR) models, i.e. models that link chemical features of compounds with activities towards a target macromolecule associated with the initiation or progression of a disease. QSAR models are computed by combining information on the physicochemical and structural features of a library of congeneric compounds, typically assembled from two or more building blocks, and biological data from one or more in vitro assays. Since the models provide information on features affecting the compounds' biological activity they can be used as guides for further optimization. However, in order for a QSAR model to be relevant to the targeted disease, and drug development in general, the compound library used must contain molecules with balanced variation of the features spanning the chemical space believed to be important for interaction with the biological target. In addition, the assays used must be robust and deliver high quality data that are directly related to the function of the biological target and the associated disease state. In this review, we discuss and exemplify the concept of statistical molecular design (SMD) in the selection of building blocks and final synthetic targets (i.e. compounds to synthesize) to generate information-rich, balanced libraries for biological testing and computation of QSAR models.

Modeling a National Collaborative Digital Library for Malaysian Secondary Schools

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N.N. Edzan

2004-09-01

Full Text Available This paper describes the conceptualisation of a model for a collaborative digital library specially tailored for Malaysian secondary schools, which will support classroom teaching and learning. The move towards collaboratively building the contents of a digital library is a fairly recent trend and it simulates an environment where partners are empowered to participate in building and up keeping the knowledge contents of the system. The conceptualisation of a Malaysian digital library is in line with the governments efforts in establishing SMART schools. However, various issues such as identifying local resources, ascertaining the needs of it users, and establishing a framework to meet these needs, must be addressed before the digital library can be fully implemented. It may be approached through the establishment of test beds in a particular learning institution, before nationwide implementation.

UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small molecule natural product libraries

Science.gov (United States)

Generation of natural product libraries containing column fractions, each with only a few small molecules, by a high throughput, automated fractionation system has made it possible to implement an improved dereplication strategy for selection and prioritization of hits in a natural product discovery...

Connecting Library Use to Student Success

Science.gov (United States)

LeMaistre, Tiffany; Shi, Qingmin; Thanki, Sandip

2018-01-01

This study investigated the relationship between use of online library resources and student success at a small, teaching-focused, baccalaureate college. Researchers also measured whether library users were representative of the student population. Use of online library resources was a significant predictor of semester grade point average (GPA),…

Reforming Prison Libraries.

Science.gov (United States)

Coyle, William J.

1989-01-01

Discusses the current widespread acceptance of the public library model for prison libraries, in which preferences of the inmates are the chief consideration in programing and collection development. It is argued that this model results in recreational programs and collections that fail to fulfill the prison library's role in education and…

Modeling of frequency agile devices: development of PKI neuromodeling library based on hierarchical network structure

Science.gov (United States)

Sanchez, P.; Hinojosa, J.; Ruiz, R.

2005-06-01

Recently, neuromodeling methods of microwave devices have been developed. These methods are suitable for the model generation of novel devices. They allow fast and accurate simulations and optimizations. However, the development of libraries makes these methods to be a formidable task, since they require massive input-output data provided by an electromagnetic simulator or measurements and repeated artificial neural network (ANN) training. This paper presents a strategy reducing the cost of library development with the advantages of the neuromodeling methods: high accuracy, large range of geometrical and material parameters and reduced CPU time. The library models are developed from a set of base prior knowledge input (PKI) models, which take into account the characteristics common to all the models in the library, and high-level ANNs which give the library model outputs from base PKI models. This technique is illustrated for a microwave multiconductor tunable phase shifter using anisotropic substrates. Closed-form relationships have been developed and are presented in this paper. The results show good agreement with the expected ones.

The Personal Virtual Library

CERN Document Server

Le Meur, Jean-Yves

1998-01-01

Looking for "library" in the usual search engines of the World Wide Web gives: "Infoseek found 3,593,126 pages containing the word library" and it nicely proposes: "Search only within these 3,59 3,126 pages ?" "Yahoo! Found 1299 categories and 8669 sites for library" "LycOs: 1-10 von 512354 relevanten Ergebnissen" "AltaVista: About 14830527 documents match your query" and at the botto m: "Word count: library: 15466897" ! Excite: Top 10 matches and it does not say how many can be browsed... "Library" on the World Wide Web is really popular. At least fiveteen million pages ar e supposed to contain this word. Half of them may have disappeared by now but one more hit will be added once the search robots will have indexed this document ! The notion of Personal Library i s a modest attempt, in a small environment like a library, to give poor users lost in cyber-libraries the opportunity to keep their own private little shelves - virtually. In this paper, we will l ook at the usual functionalities of library systems...

Nuclear models, experiments and data libraries needed for numerical simulation of accelerator-driven system

International Nuclear Information System (INIS)

Bauge, E.; Bersillon, O.

2000-01-01

This paper presents the transparencies of the speech concerning the nuclear models, experiments and data libraries needed for numerical simulation of Accelerator-Driven Systems. The first part concerning the nuclear models defines the spallation process, the corresponding models (intra-nuclear cascade, statistical model, Fermi breakup, fission, transport, decay and macroscopic aspects) and the code systems. The second part devoted to the experiments presents the angular measurements, the integral measurements, the residual nuclei and the energy deposition. In the last part, dealing with the data libraries, the author details the fundamental quantities as the reaction cross-section, the low energy transport databases and the decay libraries. (A.L.B.)

Pricing Models and Payment Schemes for Library Collections.

Science.gov (United States)

Stern, David

2002-01-01

Discusses new pricing and payment options for libraries in light of online products. Topics include alternative cost models rather than traditional subscriptions; use-based pricing; changes in scholarly communication due to information technology; methods to determine appropriate charges for different organizations; consortial plans; funding; and…

Library Use

DEFF Research Database (Denmark)

Konzack, Lars

2012-01-01

A seminar paper about a survey of role-playing games in public libraries combined with three cases and a presentation of a model.......A seminar paper about a survey of role-playing games in public libraries combined with three cases and a presentation of a model....

Multiscale Computing with the Multiscale Modeling Library and Runtime Environment

NARCIS (Netherlands)

Borgdorff, J.; Mamonski, M.; Bosak, B.; Groen, D.; Ben Belgacem, M.; Kurowski, K.; Hoekstra, A.G.

2013-01-01

We introduce a software tool to simulate multiscale models: the Multiscale Coupling Library and Environment 2 (MUSCLE 2). MUSCLE 2 is a component-based modeling tool inspired by the multiscale modeling and simulation framework, with an easy-to-use API which supports Java, C++, C, and Fortran. We

Generating Collaborative Systems for Digital Libraries: a Model-Driven Approach

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Alessio Malizia

2010-12-01

Full Text Available The design and development of a digital library involves different stakeholders, such as: information architects, librarians, and domain experts, who need to agree on a common language to describe, discuss, and negotiate the services the library has to offer. To this end, high-level, language-neutral models have to be devised. Metamodeling techniques favor the definition of domainspecific visual languages through which stakeholders can share their views and directly manipulate representations of the domain entities. This paper describes CRADLE (Cooperative-Relational Approach to Digital Library Environments, a metamodel-based framework and visual language for the definition of notions and services related to the development of digital libraries. A collection of tools allows the automatic generation of several services, defined with the CRADLE visual language, and of the graphical user interfaces providing access to them for the final user. The effectiveness of the approach is illustrated by presenting digital libraries generated with CRADLE, while the CRADLE environment has been evaluated by using the cognitive dimensions framework.

Biomass Scenario Model Scenario Library: Definitions, Construction, and Description

Energy Technology Data Exchange (ETDEWEB)

Inman, D.; Vimmerstedt, L.; Bush, B.; Peterson, S.

2014-04-01

Understanding the development of the biofuels industry in the United States is important to policymakers and industry. The Biomass Scenario Model (BSM) is a system dynamics model of the biomass-to-biofuels system that can be used to explore policy effects on biofuels development. Because of the complexity of the model, as well as the wide range of possible future conditions that affect biofuels industry development, we have not developed a single reference case but instead developed a set of specific scenarios that provide various contexts for our analyses. The purpose of this report is to describe the scenarios that comprise the BSM scenario library. At present, we have the following policy-focused scenarios in our library: minimal policies, ethanol-focused policies, equal access to policies, output-focused policies, technological diversity focused, and the point-of-production- focused. This report describes each scenario, its policy settings, and general insights gained through use of the scenarios in analytic studies.

a Model Study of Small-Scale World Map Generalization

Science.gov (United States)

Cheng, Y.; Yin, Y.; Li, C. M.; Wu, W.; Guo, P. P.; Ma, X. L.; Hu, F. M.

2018-04-01

With the globalization and rapid development every filed is taking an increasing interest in physical geography and human economics. There is a surging demand for small scale world map in large formats all over the world. Further study of automated mapping technology, especially the realization of small scale production on a large scale global map, is the key of the cartographic field need to solve. In light of this, this paper adopts the improved model (with the map and data separated) in the field of the mapmaking generalization, which can separate geographic data from mapping data from maps, mainly including cross-platform symbols and automatic map-making knowledge engine. With respect to the cross-platform symbol library, the symbol and the physical symbol in the geographic information are configured at all scale levels. With respect to automatic map-making knowledge engine consists 97 types, 1086 subtypes, 21845 basic algorithm and over 2500 relevant functional modules.In order to evaluate the accuracy and visual effect of our model towards topographic maps and thematic maps, we take the world map generalization in small scale as an example. After mapping generalization process, combining and simplifying the scattered islands make the map more explicit at 1 : 2.1 billion scale, and the map features more complete and accurate. Not only it enhance the map generalization of various scales significantly, but achieve the integration among map-makings of various scales, suggesting that this model provide a reference in cartographic generalization for various scales.

Building Component Library: An Online Repository to Facilitate Building Energy Model Creation; Preprint

Energy Technology Data Exchange (ETDEWEB)

Fleming, K.; Long, N.; Swindler, A.

2012-05-01

This paper describes the Building Component Library (BCL), the U.S. Department of Energy's (DOE) online repository of building components that can be directly used to create energy models. This comprehensive, searchable library consists of components and measures as well as the metadata which describes them. The library is also designed to allow contributors to easily add new components, providing a continuously growing, standardized list of components for users to draw upon.

Sustaining librarian vitality: embedded librarianship model for health sciences libraries.

Science.gov (United States)

Wu, Lin; Mi, Misa

2013-01-01

With biomedical information widely accessible from anywhere at any time, health sciences libraries have become less centralized, and they are challenged to stay relevant and vital to the mission and strategic goals of their home institution. One solution is to embed librarians at strategic points in health professions' education, research, and patient care. This article discusses a proposed five-level model of embedded librarianship within the context of health sciences libraries and describes different roles, knowledge, and skills desirable for health sciences librarians working as embedded librarians.

Financing the Electronic Library: Models and Options.

Science.gov (United States)

Waters, Richard L.; Kralisz, Victor Frank

1981-01-01

Places the cost considerations associated with public library automation in a framework of public finance comfortable to most administrators, discusses the importance of experience with use patterns in the electronic library in opening up new and innovative financing methods, and stresses the role of the library in the information industry. (JL)

A Model of RHIC Using the Unified Accelerator Libraries

Energy Technology Data Exchange (ETDEWEB)

Pilat, F. [Brookhaven National Lab. (BNL), Upton, NY (United States); Tepikian, S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Trahern, C. G. [Brookhaven National Lab. (BNL), Upton, NY (United States); Malitsky, N. [Cornell Univ., Ithaca, NY (United States)

1998-01-01

The Unified Accelerator Library (UAL) is an object oriented and modular software environment for accelerator physics which comprises an accelerator object model for the description of the machine (SMF, for Standard Machine Format), a collection of Physics Libraries, and a Perl inte,face that provides a homo­geneous shell for integrating and managing these components. Currently available physics libraries include TEAPOT++, a collection of C++ physics modules conceptually derived from TEAPOT, and DNZLIB, a differential algebra package for map generation. This software environment has been used to build a flat model of RHIC which retains the hierarchical lat­tice description while assigning specific characteristics to individual elements, such as measured field har­monics. A first application of the model and of the simulation capabilities of UAL has been the study of RHIC stability in the presence of siberian snakes and spin rotators. The building blocks of RHIC snakes and rotators are helical dipoles, unconventional devices that can not be modeled by traditional accelerator phys­ics codes and have been implemented in UAL as Taylor maps. Section 2 describes the RHIC data stores, Section 3 the RHIC SMF format and Section 4 the RHIC spe­cific Perl interface (RHIC Shell). Section 5 explains how the RHIC SMF and UAL have been used to study the RHIC dynamic behavior and presents detuning and dynamic aperture results. If the reader is not familiar with the motivation and characteristics of UAL, we include in the Appendix an useful overview paper. An example of a complete set of Perl Scripts for RHIC simulation can also be found in the Appendix.

Using scientific evidence to improve hospital library services: Southern Chapter/Medical Library Association journal usage study.

Science.gov (United States)

Dee, C R; Rankin, J A; Burns, C A

1998-07-01

Journal usage studies, which are useful for budget management and for evaluating collection performance relative to library use, have generally described a single library or subject discipline. The Southern Chapter/Medical Library Association (SC/MLA) study has examined journal usage at the aggregate data level with the long-term goal of developing hospital library benchmarks for journal use. Thirty-six SC/MLA hospital libraries, categorized for the study by size as small, medium, or large, reported current journal title use centrally for a one-year period following standardized data collection procedures. Institutional and aggregate data were analyzed for the average annual frequency of use, average costs per use and non-use, and average percent of non-used titles. Permutation F-type tests were used to measure difference among the three hospital groups. Averages were reported for each data set analysis. Statistical tests indicated no significant differences between the hospital groups, suggesting that benchmarks can be derived applying to all types of hospital libraries. The unanticipated lack of commonality among heavily used titles pointed to a need for uniquely tailored collections. Although the small sample size precluded definitive results, the study's findings constituted a baseline of data that can be compared against future studies.

A Web-Based Electronic Book (e-book) Library: The netLibrary Model.

Science.gov (United States)

Connaway, Lynn Silipigni

2001-01-01

Identifies elements that are important for academic libraries to use in evaluating electronic books, including content; acquisition and collection development; software and hardware standards and protocols; digital rights management; access; archiving; privacy; the market and pricing; and enhancements and ideal features. Describes netLibrary, a…

Applying DEA Technique to Library Evaluation in Academic Research Libraries.

Science.gov (United States)

Shim, Wonsik

2003-01-01

This study applied an analytical technique called Data Envelopment Analysis (DEA) to calculate the relative technical efficiency of 95 academic research libraries, all members of the Association of Research Libraries. DEA, with the proper model of library inputs and outputs, can reveal best practices in the peer groups, as well as the technical…

Two agricultural production data libraries for risk assessment models

International Nuclear Information System (INIS)

Baes, C.F. III; Shor, R.W.; Sharp, R.D.; Sjoreen, A.L.

1985-01-01

Two data libraries based on the 1974 US Census of Agriculture are described. The data packages (AGDATC and AGDATG) are available from the Radiation Shielding Information Center (RSIC), Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831. Agricultural production and land-use information by county (AGDATC) or by 1/2 by 1/2 degree longitude-latitude grid cell (AGDATG) provide geographical resolution of the data. The libraries were designed for use in risk assessment models that simulate the transport of radionuclides from sources of airborne release through food chains to man. However, they are also suitable for use in the assessment of other airborne pollutants that can affect man from a food ingestion pathway such as effluents from synfuels or coal-fired power plants. The principal significance of the data libraries is that they provide default location-specific food-chain transport parameters when site-specific information are unavailable. Plant food categories in the data libraries include leafy vegetables, vegetables and fruits exposed to direct deposition of airborne pollutants, vegetables and fruits protected from direct deposition, and grains. Livestock feeds are also tabulated in four categories: pasture, grain, hay, and silage. Pasture was estimated by a material balance of cattle and sheep inventories, forage feed requirements, and reported harvested forage. Cattle (Bos spp.), sheep (Ovis aries), goat (Capra hircus), hog (Sus scrofa), chicken (Gallus domesticus), and turkey (Meleagris gallopavo) inventories or sales are also tabulated in the data libraries and can be used to provide estimates of meat, eggs, and milk production. Honey production also is given. Population, irrigation, and meteorological information are also listed

In-House Automation of a Small Library Using a Mainframe Computer.

Science.gov (United States)

Waranius, Frances B.; Tellier, Stephen H.

1986-01-01

An automated library routine management system was developed in-house to create system unique to the Library and Information Center, Lunar and Planetary Institute, Houston, Texas. A modular approach was used to allow continuity in operations and services as system was implemented. Acronyms and computer accounts and file names are appended.…

Expedient preparation of nazlinine and a small library of indole alkaloids using flow electrochemistry as an enabling technology.

Science.gov (United States)

Kabeshov, Mikhail A; Musio, Biagia; Murray, Philip R D; Browne, Duncan L; Ley, Steven V

2014-09-05

An expedient synthesis of the indole alkaloid nazlinine is reported. Judicious choice of flow electrochemistry as an enabling technology has permitted the rapid generation of a small library of unnatural relatives of this biologically active molecule. Furthermore, by conducting the key electrochemical Shono oxidation in a flow cell, the loading of electrolyte can be significantly reduced to 20 mol % while maintaining a stable, broadly applicable process.

SCHOOL COMMUNITY PERCEPTION OF LIBRARY APPS AGAINTS LIBRARY EMPOWERMENT

Directory of Open Access Journals (Sweden)

Achmad Riyadi Alberto

2017-07-01

Full Text Available Abstract. This research is motivated by the development of information and communication technology (ICT in the library world so rapidly that allows libraries in the present to develop its services into digital-based services. This study aims to find out the school community’s perception of library apps developed by Riche Cynthia Johan, Hana Silvana, and Holin Sulistyo and its influence on library empowerment at the library of SD Laboratorium Percontohan UPI Bandung. Library apps in this research belong to the context of m-libraries, which is a library that meets the needs of its users by using mobile platforms such as smartphones,computers, and other mobile devices. Empowerment of library is the utilization of all aspects of the implementation of libraries to the best in order to achieve the expected goals. An analysis of the schoolcommunity’s perception of library apps using the Technology Acceptance Model (TAM includes: ease of use, usefulness, usability, usage trends, and real-use conditions. While the empowerment of the library includes aspects: information empowerment, empowerment of learning resources, empowerment of human resources, empowerment of library facilities, and library promotion. The research method used in this research is descriptive method with quantitative approach. Population and sample in this research is school community at SD Laboratorium Percontohan UPI Bandung. Determination of sample criteria by using disproportionate stratified random sampling with the number of samples of 83 respondents. Data analysis using simple linear regression to measure the influence of school community perception about library apps to library empowerment. The result of data analysis shows that there is influence between school community perception about library apps to library empowerment at library of SD Laboratorium Percontohan UPI Bandung which is proved by library acceptance level and library empowerment improvement.

Hyperopt: a Python library for model selection and hyperparameter optimization

Science.gov (United States)

Bergstra, James; Komer, Brent; Eliasmith, Chris; Yamins, Dan; Cox, David D.

2015-01-01

Sequential model-based optimization (also known as Bayesian optimization) is one of the most efficient methods (per function evaluation) of function minimization. This efficiency makes it appropriate for optimizing the hyperparameters of machine learning algorithms that are slow to train. The Hyperopt library provides algorithms and parallelization infrastructure for performing hyperparameter optimization (model selection) in Python. This paper presents an introductory tutorial on the usage of the Hyperopt library, including the description of search spaces, minimization (in serial and parallel), and the analysis of the results collected in the course of minimization. This paper also gives an overview of Hyperopt-Sklearn, a software project that provides automatic algorithm configuration of the Scikit-learn machine learning library. Following Auto-Weka, we take the view that the choice of classifier and even the choice of preprocessing module can be taken together to represent a single large hyperparameter optimization problem. We use Hyperopt to define a search space that encompasses many standard components (e.g. SVM, RF, KNN, PCA, TFIDF) and common patterns of composing them together. We demonstrate, using search algorithms in Hyperopt and standard benchmarking data sets (MNIST, 20-newsgroups, convex shapes), that searching this space is practical and effective. In particular, we improve on best-known scores for the model space for both MNIST and convex shapes. The paper closes with some discussion of ongoing and future work.

Intelligent Libraries and Apomediators: Distinguishing between Library 3.0 and Library 2.0

Science.gov (United States)

Kwanya, Tom; Stilwell, Christine; Underwood, Peter G.

2013-01-01

Using the "point oh" naming system for developments in librarianship is attracting debate about its appropriateness, basis and syntax and the meaning and potential of Library 2.0. Now a new term, Library 3.0, has emerged. Is there is any significant difference between the two models? Using documentary analysis to explore the terms, the…

Development of special libraries in Slovenia

OpenAIRE

Nada Češnovar

2002-01-01

Although Slovenia is a small European country with only 2 million inhabitants, Slovenian librarianship can be compared with any other bigger country. The staffing and information technology in special libraries have been accelerating for the last four decades.Seventeen years have passed since the first meeting of special libraries. When Slovenia attained independence, numerous changes occured in the field of special librarianship.Due to the economic crisis, several special libraries of enterp...

An Integrated Library System: Preliminary Considerations.

Science.gov (United States)

Neroda, Edward

Noting difficulties experienced by small to medium sized colleges in acquiring integrated library computer systems, this position paper outlines issues related to the subject with the intention of increasing familiarity and interest in integrated library systems. The report includes: a brief review of technological advances as they relate to…

Berlin Reflectance Spectral Library (BRSL)

Science.gov (United States)

Henckel, D.; Arnold, G.; Kappel, D.; Moroz, L. V.; Markus, K.

2017-09-01

The Berlin Reflectance Spectral Library (BRSL) provides a collection of reflectance spectra between 0.3 and 17 µm. It was originally dedicated to support space missions to small solar system bodies. Meanwhile the library includes selections of biconical reflectance spectra for spectral data analysis of other planetary bodies as well. The library provides reference spectra of well-characterized terrestrial analogue materials and meteorites for interpretation of remote sensing reflectance spectra of planetary surfaces. We introduce the BRSL, summarize the data available, and access to use them for further relevant applications.

Performance of the libraries in Isfahan University of Medical Sciences based on the EFQM model.

Science.gov (United States)

Karimi, Saeid; Atashpour, Bahareh; Papi, Ahmad; Nouri, Rasul; Hasanzade, Akbar

2014-01-01

Performance measurement is inevitable for university libraries. Hence, planning and establishing a constant and up-to-date measurement system is required for the libraries, especially the university libraries. The primary studies and analyses reveal that the EFQM Excellence Model has been efficient, and the administrative reform program has focused on the implementation of this model. Therefore, on the basis of these facts as well as the need for a measurement system, the researchers measured the performance of libraries in schools and hospitals supported by Isfahan University of Medical Sciences, using the EFQM Organizational Excellence Model. This descriptive research study was carried out by a cross-sectional survey method in 2011. This research study included librarians and library directors of Isfahan University of Medical Sciences (70 people). The validity of the instrument was measured by the specialists in the field of Management and Library Science. To measure the reliability of the questionnaire, the Cronbach's alpha coefficient value was measured (0.93). The t-test, ANOVA, and Spearman's rank correlation coefficient were used for measurements. The data were analyzed by SPSS. Data analysis revealed that the mean score of the performance measurement for the libraries under study and between nine dimensions the highest score was 65.3% for leadership dimension and the lowest scores were 55.1% for people and 55.1% for society results. In general, using the ninth EFQM model the average level of all dimensions, which is in good agreement with normal values, was assessed. However, compared to other results, the criterion people and society results were poor. It is Recommended by forming the expert committee on criterion people and society results by individuals concerned with the various conferences and training courses to improve the aspects.

SU-E-J-93: Development of Pre-Contoured Human Model Library in DICOM-RT Format for the Epidemiological Study of the Radiotherapy Patients

International Nuclear Information System (INIS)

Pyakuryal, A; Lee, C; Lee, C; Pelletier, C; Jung, J

2015-01-01

Purpose: Prior to 3D conformal radiation therapy planning, patient anatomy information was mostly limited to 2D beams-eye-view from the conventional simulator. To analyze the outcomes of such treatments for radiation late effects, 3D computational human models are often used in commercial treatment planning systems (TPSs). However, several underlying difficulties such as time-consuming manual delineation procedures of a large number of structures in the model have always limited its applications. Primary objective of this work was to develop a human model library for the epidemiological study by converting 3D-surface model organs to DICOM-RT format (DICOM-RT structure) using an in-house built software. We converted the ICRP reference human models to DICOM-RT models, which can be readily adopted for various dose calculations. Methods: MATLAB based code were utilized to convert the contour drawings extracted in text-format from the 3D graphic-tool, Rhinoceros into DICOM-RT structure format for 50 different organs of each model using a 16GB dual-core processor. The conversion periods were measured for each DICOM-RT models, and the reconstructed structure volumes were validated against the original 3D-surface models in the TPS. Ten reference hybrid whole-body models (8-pediatric and 2-adults) were automatically processed to create DICOM-RT computational human model library. Results: Mean contour conversion period was found to be 580 (N=2) and 394.5 (N=8) seconds for 50 organs in the adult and pediatric models respectively. A good agreement for large organs (NRMSD <1.0%) and small organs (NRMSD <7.7%) was also observed between the original volumes and corresponding DICOM-RT structure volumes of the organs. Conclusion: The ICRP reference human models were converted into DICOM-RT format to support the epidemiological study using a large cohort of conventional radiotherapy patients. Due to its DICOM-compatibility, the library may be implemented to many other different

SU-E-J-93: Development of Pre-Contoured Human Model Library in DICOM-RT Format for the Epidemiological Study of the Radiotherapy Patients

Energy Technology Data Exchange (ETDEWEB)

Pyakuryal, A; Lee, C [National Cancer Institute, Rockville, MD (United States); Lee, C [University of Michigan, Ann Arbor, MI (United States); Pelletier, C [East Carolina University, Greenville, NC (United States); Jung, J [East Carolina Univ, Greenville, NC (United States)

2015-06-15

Purpose: Prior to 3D conformal radiation therapy planning, patient anatomy information was mostly limited to 2D beams-eye-view from the conventional simulator. To analyze the outcomes of such treatments for radiation late effects, 3D computational human models are often used in commercial treatment planning systems (TPSs). However, several underlying difficulties such as time-consuming manual delineation procedures of a large number of structures in the model have always limited its applications. Primary objective of this work was to develop a human model library for the epidemiological study by converting 3D-surface model organs to DICOM-RT format (DICOM-RT structure) using an in-house built software. We converted the ICRP reference human models to DICOM-RT models, which can be readily adopted for various dose calculations. Methods: MATLAB based code were utilized to convert the contour drawings extracted in text-format from the 3D graphic-tool, Rhinoceros into DICOM-RT structure format for 50 different organs of each model using a 16GB dual-core processor. The conversion periods were measured for each DICOM-RT models, and the reconstructed structure volumes were validated against the original 3D-surface models in the TPS. Ten reference hybrid whole-body models (8-pediatric and 2-adults) were automatically processed to create DICOM-RT computational human model library. Results: Mean contour conversion period was found to be 580 (N=2) and 394.5 (N=8) seconds for 50 organs in the adult and pediatric models respectively. A good agreement for large organs (NRMSD <1.0%) and small organs (NRMSD <7.7%) was also observed between the original volumes and corresponding DICOM-RT structure volumes of the organs. Conclusion: The ICRP reference human models were converted into DICOM-RT format to support the epidemiological study using a large cohort of conventional radiotherapy patients. Due to its DICOM-compatibility, the library may be implemented to many other different

High-performance small-scale solvers for linear Model Predictive Control

DEFF Research Database (Denmark)

Frison, Gianluca; Sørensen, Hans Henrik Brandenborg; Dammann, Bernd

2014-01-01

, with the two main research areas of explicit MPC and tailored on-line MPC. State-of-the-art solvers in this second class can outperform optimized linear-algebra libraries (BLAS) only for very small problems, and do not explicitly exploit the hardware capabilities, relying on compilers for that. This approach...

Open Source Library Management Systems: A Multidimensional Evaluation

Science.gov (United States)

Balnaves, Edmund

2008-01-01

Open source library management systems have improved steadily in the last five years. They now present a credible option for small to medium libraries and library networks. An approach to their evaluation is proposed that takes account of three additional dimensions that only open source can offer: the developer and support community, the source…

Eliminating traditional reference services in an academic health sciences library: a case study

Science.gov (United States)

Schulte, Stephanie J

2011-01-01

Question: How were traditional librarian reference desk services successfully eliminated at one health sciences library? Setting: The analysis was done at an academic health sciences library at a major research university. Method: A gap analysis was performed, evaluating changes in the first eleven months through analysis of reference transaction and instructional session data. Main Results: Substantial increases were seen in the overall number of specialized reference transactions and those conducted by librarians lasting more than thirty minutes. The number of reference transactions overall increased after implementing the new model. Several new small-scale instructional initiatives began, though perhaps not directly related to the new model. Conclusion: Traditional reference desk services were eliminated at one academic health sciences library without negative impact on reference and instructional statistics. Eliminating ties to the confines of the physical library due to staffing reference desk hours removed one significant barrier to a more proactive liaison program. PMID:22022221

Preliminary assessment of Geant4 HP models and cross section libraries by reactor criticality benchmark calculations

DEFF Research Database (Denmark)

Cai, Xiao-Xiao; Llamas-Jansa, Isabel; Mullet, Steven

2013-01-01

Geant4 is an open source general purpose simulation toolkit for particle transportation in matter. Since the extension of the thermal scattering model in Geant4.9.5 and the availability of the IAEA HP model cross section libraries, it is now possible to extend the application area of Geant4......, U and O in uranium dioxide, Al metal, Be metal, and Fe metal. The native HP cross section library G4NDL does not include data for elements with atomic number larger than 92. Therefore, transuranic elements, which have impacts for a realistic reactor, can not be simulated by the combination of the HP...... models and the G4NDL library. However, cross sections of those missing isotopes were made available recently through the IAEA project “new evaluated neutron cross section libraries for Geant4”....

The National Resource Library for Science and Technology in Sweden: A Nordic model of cooperating technology libraries

Science.gov (United States)

Lagar, Gunnar

1994-01-01

The scope of this presentation is to give a state-of-the-art report on the present situation of Nordic technology libraries, to elaborate on a plan for national resource libraries in Sweden, and to share how the Royal Institute of Technology Library in Stockholm (KTHB) has fostered a network of cooperating libraries in order to optimize government funding for the system of resource libraries.

Education and Outreach Programs at the Reagan Library.

Science.gov (United States)

Cumming, Gregory G.

This exploration of the need and potential for education and outreach programs at the Reagan Library begins by examining factors that make the Reagan library unique, i.e., its proximity to Los Angeles and a small town setting, closeness to the Nixon Library and birthplace, and Ronald Reagan's popularity. It is noted that, since the Reagan Library…

A Two-Tiered Model for Analyzing Library Web Site Usage Statistics, Part 1: Web Server Logs.

Science.gov (United States)

Cohen, Laura B.

2003-01-01

Proposes a two-tiered model for analyzing web site usage statistics for academic libraries: one tier for library administrators that analyzes measures indicating library use, and a second tier for web site managers that analyzes measures aiding in server maintenance and site design. Discusses the technology of web site usage statistics, and…

Planetary Image Geometry Library

Science.gov (United States)

Deen, Robert C.; Pariser, Oleg

2010-01-01

The Planetary Image Geometry (PIG) library is a multi-mission library used for projecting images (EDRs, or Experiment Data Records) and managing their geometry for in-situ missions. A collection of models describes cameras and their articulation, allowing application programs such as mosaickers, terrain generators, and pointing correction tools to be written in a multi-mission manner, without any knowledge of parameters specific to the supported missions. Camera model objects allow transformation of image coordinates to and from view vectors in XYZ space. Pointing models, specific to each mission, describe how to orient the camera models based on telemetry or other information. Surface models describe the surface in general terms. Coordinate system objects manage the various coordinate systems involved in most missions. File objects manage access to metadata (labels, including telemetry information) in the input EDRs and RDRs (Reduced Data Records). Label models manage metadata information in output files. Site objects keep track of different locations where the spacecraft might be at a given time. Radiometry models allow correction of radiometry for an image. Mission objects contain basic mission parameters. Pointing adjustment ("nav") files allow pointing to be corrected. The object-oriented structure (C++) makes it easy to subclass just the pieces of the library that are truly mission-specific. Typically, this involves just the pointing model and coordinate systems, and parts of the file model. Once the library was developed (initially for Mars Polar Lander, MPL), adding new missions ranged from two days to a few months, resulting in significant cost savings as compared to rewriting all the application programs for each mission. Currently supported missions include Mars Pathfinder (MPF), MPL, Mars Exploration Rover (MER), Phoenix, and Mars Science Lab (MSL). Applications based on this library create the majority of operational image RDRs for those missions. A

Online Library of Scientific Models, A New Way to Teach, Learn, and Share Learning Experience

Directory of Open Access Journals (Sweden)

Hatem H. Elrefaei

2008-05-01

Full Text Available While scientific models are usually communicated in paper format, the need to reprogram every model by every user results in a huge loss of efforts, time and money, hence lengthening the educational and research developing cycle and loosing the learning experience and expertise gained by every user. We demonstrate a new portal www.imodelit.com that hosts a library of scientific models for electrical engineers in the form of java applets. They are all conformal, informative, with strong input and output filing system. The software design allows a fast developing cycle and it represents a strong infrastructure that can be shared by researchers to develop their own applets to be posted on the library. We aim for a community based library of scientific models that enhances the e-learning process for engineering students.

Development of special libraries in Slovenia

Directory of Open Access Journals (Sweden)

Nada Češnovar

2002-01-01

Full Text Available Although Slovenia is a small European country with only 2 million inhabitants, Slovenian librarianship can be compared with any other bigger country. The staffing and information technology in special libraries have been accelerating for the last four decades.Seventeen years have passed since the first meeting of special libraries. When Slovenia attained independence, numerous changes occured in the field of special librarianship.Due to the economic crisis, several special libraries of enterprises were abolished, while on the other hand, the number of special libraries in public institutions has increased. The article deals with the changes which have influenced the development of special librarianship in Slovenia.

Development of probabilistic risk analysis library

International Nuclear Information System (INIS)

Soga, Shota; Kirimoto, Yukihiro; Kanda, Kenichi

2015-01-01

We developed a library that is designed to perform level 1 Probabilistic Risk Analysis using Binary Decision Diagram (BDD). In particular, our goal is to develop a library that will allow Japanese electric utilities to take the advantages of BDD that can solve Event Tree (ET) and Fault Tree (FT) models analytically. Using BDD, the library supports negation in FT which allows more flexible modeling of ET/FT. The library is written by C++ within an object-oriented framework using open source software. The library itself is a header-only library so that Japanese electric utilities can take advantages of its transparency to speed up development and to build their own software for their specific needs. In this report, the basic capabilities of the library is briefly described. In addition, several applications of the library are demonstrated including validation of MCS evaluation of PRA model and evaluation of corrective and preventive maintenance considering common cause failure. (author)

Comparison of WIMS results using libraries based on new evaluated data files

International Nuclear Information System (INIS)

Trkov, A.; Ganesan, S.; Zidi, T.

1996-01-01

A number of selected benchmark experiments have been modelled with the WIMS-D/4 lattice code. Calculations were performed using multigroup libraries generated from a number of newly released evaluated data files. Data processing was done with the NJOY91.38 code. Since the data processing methods were the same in all cases, the results may serve to determine the impact on integral parameters due to differences in the basic data. The calculated integral parameters were also compared to the measured values. Observed differences were small, which means that there are no essential differences between the evaluated data libraries. The results of the analysis cannot serve to discriminate in terms of quality of the data between the evaluated data libraries considered. For the test cases considered the results with the new, unadjusted libraries are at least as good as those obtained with the old, adjusted WIMS library which is supplied with the code. (author). 16 refs, 3 tabs

Portuguese School Libraries Evaluation Model: An Analysis of Primary Schools' Results for the "Reading and Literacy" Domain

Science.gov (United States)

Martins, Jorge Tiago; Martins, Rosa Maria

2012-01-01

This paper reports the implementation results of the Portuguese School Libraries Evaluation Model, more specifically the results of primary schools self-evaluation of their libraries' reading promotion and information literacy development activities. School libraries that rated their performance as either "Excellent" or "Poor"…

The Managerial Roles of Academic Library Directors: The Mintzberg Model.

Science.gov (United States)

Moskowitz, Michael Ann

1986-01-01

A study based on a model developed by Henry Mintzberg examined the internal and external managerial roles of 126 New England college and university library directors. Survey results indicate that the 97 responding directors were primarily involved with internal managerial roles and work contacts. (CDD)

Literature promotion in Public Libraries

DEFF Research Database (Denmark)

Kann-Christensen, Nanna; Balling, Gitte

2011-01-01

This article discusses a model that can be used in order to analyse notions on literature promotion in public libraries. The model integrates different issues which interact with how literature promotion is understood and thought of in public libraries. Besides cultural policy we regard the logics...... of new public management (NPM) and professional logics in the field of public libraries. Cultural policy along with the identification of underlying logics present among politicians, government officials, managers and librarians/promoters of literature, play an important part in creating an understanding...... of literature promotion in Danish libraries. Thus the basic premise for the development of the model is that cultural policy (Policy) has an important influence on notions on literature promotion and other activities in public libraries, but that cultural policy must be seen in some kind of interaction...

Library Services Funding Assessment

Science.gov (United States)

Lorig, Jonathan A.

2004-01-01

The Glenn Technical Library is a science and engineering library that primarily supports research activities at the Glenn Research Center, and provides selected services to researchers at all of the NASA research centers. Resources available in the library include books, journals, CD-ROMs, and access to various online sources, as well as live reference and inter-library loan services. The collection contains over 77,000 books, 800,000 research reports, and print or online access to over 1,400 journals. Currently the library operates within the Logistics and Technical Information Division, and is funded as an open-access resource within the GRC. Some of the research units at the GRC have recently requested that the library convert to a "pay-for-services" model, in which individual research units could fund only those journal subscriptions for which they have a specific need. Under this model, the library would always maintain a certain minimum level of pooled-expense services, including the ready reference and book collections, and inter-library loan services. Theoretically the "pay-for-services" model would encourage efficient financial allocation, and minimize the extent to which paid journal subscriptions go unused. However, this model also could potentially negate the benefits of group purchases for journal subscriptions and access. All of the major journal publishers offer package subscriptions that compare favorably in cost with the sum of individual subscription costs for a similar selection of titles. Furthermore, some of these subscription packages are "consortium" purchases that are funded collectively by the libraries at multiple NASA research centers; such consortia1 memberships would be difficult for the library to pay, if enough GRC research units were to withdraw their pooled contributions. cost of collectively-funded journal access with the cost of individual subscriptions. My primary task this summer is to create the cost dataset framework, and

Development of the acquisition model of online information resources at Faculty of Medicine Library, Khon Kaen University.

Science.gov (United States)

Thanapaisal, Soodjai; Thanapaisal, Chaiwit

2013-09-01

Faculty of Medicine Library, Khon Kaen University started to acquire online information resources since 2001 with the subscriptions to 2 databases. Nowadays it has 29 items of subscriptions and the expenses on online information resources reach to 17 million baht, more than 70 percent of the information resources budget, serving the academic purposes of the Faculty of Medicine. The problems of online information resources acquisition fall into 4 categories, and lead to 4 aspects conforming the model of the acquisition, comparing or benchmarking with the 4 selected medical school libraries in Bangkok, Chiang Mai, and Songkhla, and discussion with some other Thai and foreign libraries. The acquisition model of online information resources is developed from those problems and proposed for Faculty of Medicine Library, Khon Kaen University as well as for any medical libraries which prefer.

NJOY processed multigroup library for fast reactor applications and point data library for MCNP - Experience and validation

International Nuclear Information System (INIS)

Kim Jung-Do; Gil Choong-Sup

1996-01-01

JEF-1-based 50-group cross section library for fast reactor applications and point data library for continuous-energy Monte Carlo code MCNP have been generated using NJOY91.38 system. They have been examined by analyzing measured integral quantities such as criticality and central reaction rate ratios for 8 small fast critical assemblies. (author). 9 refs, 2 figs, 10 tabs

Solid-Phase Synthesis of Small Molecule Libraries using Double Combinatorial Chemistry

DEFF Research Database (Denmark)

Nielsen, John; Jensen, Flemming R.

1997-01-01

The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can be demons......The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can...

Library system of Italy

Directory of Open Access Journals (Sweden)

Nataša Gerbec

2003-01-01

Full Text Available In the European extent, Italy is the cradle of libraries and library sciences. In the past, Italian national public libraries played an important role through their vast book treasury. But only during the last thirty years have public libraries been developed following the Anglo-American public library model. Italy does not have any uniform or general legislation concerning libraries. On the state level, this area is regulated by some separate acts, while on the regional level there is a collection of various acts and regulations. Libraries are not strictly divided into general categories. It is required that the professionals engaged in Italian libraries should have secondary or university education. The level of their professional tasks depends on the type of library and its capacity. The competency for the development in the field of librarianship is assigned to The Ministry of Cultural and Environment Heritage as well as to its subordinate institutions (Central Institute for the Union catalogue of Italian Libraries and for Bibliographic Information, Central Institute for Book Pathology, Observatory for International Libraries Programmes.

A library treasure hunt – An alternative way to introduce new university students to the library

Directory of Open Access Journals (Sweden)

Kristina Holmin Verdozzi

2013-12-01

Full Text Available Introducing new students to the library and its resources during the first hectic weeks at university can pose a considerable challenge. We have to compete with many other kinds of introductory activities, making new friends, becoming acquainted with the subject, not to mention all the parties and social functions arranged for new students. The traditional lecture, or showing large groups of tired students around the library just wasn't working. So, a few years ago, we started to think about radical new ways of introducing students to the library. We hit upon the idea of arranging a treasure hunt. Students working in small groups have to carry out various tasks at different stations in different libraries. When each task has been successfully completed, a verbal report is made to the librarian at that library, and students can ask questions, before going on to the next task. By carrying out actual tasks, the students become familiar with the important aspects of library resources; learning by doing and having fun at the same time. The "treasure" at the end of the hunt was an apple, a sweet, a pencil, a small LED flashlight and information brochures about the library and the master programme in physics. One of the decisive factors in the success of this activity was the cooperation of lecturers, who integrated it into their introductory programme. It also had high status, as it was a compulsory activity, thanks to the commitment and understanding of lecturers. The treasure hunt is important in the students' later studies as they know which library resources are available, and they recognise the librarians. This lowers the threshold for the further development of the students' information gathering skills. The success of this activity in one of the subjects taught at the Department of Physics has led to the decision to make the library treasure hunt compulsory for all students at the Department, in both the Engineering Faculty and the Science

Content Management for the Virtual Library

Directory of Open Access Journals (Sweden)

Ed Salazar

2006-09-01

Full Text Available Traditional, larger libraries can rely on their physical collection, coffee shops, and study rooms as ways to entice patrons into their library. Yet virtual libraries merely have their online presence to attract students to resources. This can only be achieved by providing a fully functional site that is well designed and organized, allowing patrons to navigate and locate information easily. One such technology significantly improving the overall usefulness of Web sites is a content management system (CMS. Although the CMS is not a novel technology per se, it is a technology smaller libraries cannot afford to ignore. In the fall of 2004, the Northcentral University Electronic Learning Resources Center (ELRC, a small, virtual library, moved from a static to a database-driven Web site. This article explains the importance of a CMS for the virtual or smaller library and describes the methodology used by ELRC to complete the project.

Architectural Optimization of Digital Libraries

Science.gov (United States)

Biser, Aileen O.

1998-01-01

This work investigates performance and scaling issues relevant to large scale distributed digital libraries. Presently, performance and scaling studies focus on specific implementations of production or prototype digital libraries. Although useful information is gained to aid these designers and other researchers with insights to performance and scaling issues, the broader issues relevant to very large scale distributed libraries are not addressed. Specifically, no current studies look at the extreme or worst case possibilities in digital library implementations. A survey of digital library research issues is presented. Scaling and performance issues are mentioned frequently in the digital library literature but are generally not the focus of much of the current research. In this thesis a model for a Generic Distributed Digital Library (GDDL) and nine cases of typical user activities are defined. This model is used to facilitate some basic analysis of scaling issues. Specifically, the calculation of Internet traffic generated for different configurations of the study parameters and an estimate of the future bandwidth needed for a large scale distributed digital library implementation. This analysis demonstrates the potential impact a future distributed digital library implementation would have on the Internet traffic load and raises questions concerning the architecture decisions being made for future distributed digital library designs.

Scanning electron microscope measurement of width and shape of 10nm patterned lines using a JMONSEL-modeled library.

Science.gov (United States)

Villarrubia, J S; Vladár, A E; Ming, B; Kline, R J; Sunday, D F; Chawla, J S; List, S

2015-07-01

The width and shape of 10nm to 12 nm wide lithographically patterned SiO2 lines were measured in the scanning electron microscope by fitting the measured intensity vs. position to a physics-based model in which the lines' widths and shapes are parameters. The approximately 32 nm pitch sample was patterned at Intel using a state-of-the-art pitch quartering process. Their narrow widths and asymmetrical shapes are representative of near-future generation transistor gates. These pose a challenge: the narrowness because electrons landing near one edge may scatter out of the other, so that the intensity profile at each edge becomes width-dependent, and the asymmetry because the shape requires more parameters to describe and measure. Modeling was performed by JMONSEL (Java Monte Carlo Simulation of Secondary Electrons), which produces a predicted yield vs. position for a given sample shape and composition. The simulator produces a library of predicted profiles for varying sample geometry. Shape parameter values are adjusted until interpolation of the library with those values best matches the measured image. Profiles thereby determined agreed with those determined by transmission electron microscopy and critical dimension small-angle x-ray scattering to better than 1 nm. Published by Elsevier B.V.

Scanning electron microscope measurement of width and shape of 10 nm patterned lines using a JMONSEL-modeled library

Energy Technology Data Exchange (ETDEWEB)

Villarrubia, J.S., E-mail: john.villarrubia@nist.gov [Semiconductor and Dimensional Metrology Division, National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States); Vladár, A.E.; Ming, B. [Semiconductor and Dimensional Metrology Division, National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States); Kline, R.J.; Sunday, D.F. [Materials Science and Engineering Division, National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States); Chawla, J.S.; List, S. [Intel Corporation, RA3-252, 5200 NE Elam Young Pkwy, Hillsboro, OR 97124 (United States)

2015-07-15

The width and shape of 10 nm to 12 nm wide lithographically patterned SiO{sub 2} lines were measured in the scanning electron microscope by fitting the measured intensity vs. position to a physics-based model in which the lines' widths and shapes are parameters. The approximately 32 nm pitch sample was patterned at Intel using a state-of-the-art pitch quartering process. Their narrow widths and asymmetrical shapes are representative of near-future generation transistor gates. These pose a challenge: the narrowness because electrons landing near one edge may scatter out of the other, so that the intensity profile at each edge becomes width-dependent, and the asymmetry because the shape requires more parameters to describe and measure. Modeling was performed by JMONSEL (Java Monte Carlo Simulation of Secondary Electrons), which produces a predicted yield vs. position for a given sample shape and composition. The simulator produces a library of predicted profiles for varying sample geometry. Shape parameter values are adjusted until interpolation of the library with those values best matches the measured image. Profiles thereby determined agreed with those determined by transmission electron microscopy and critical dimension small-angle x-ray scattering to better than 1 nm.

Cost Accounting and Analysis for University Libraries.

Science.gov (United States)

Leimkuhler, Ferdinand F.; Cooper, Michael D.

The approach to library planning studied in this report is the use of accounting models to measure library costs and implement program budgets. A cost-flow model for a university library is developed and listed with historical data from the Berkeley General Library. Various comparisons of an exploratory nature are made of the unit costs for…

Linux Adventures on a Laptop. Computers in Small Libraries

Science.gov (United States)

Roberts, Gary

2005-01-01

This article discusses the pros and cons of open source software, such as Linux. It asserts that despite the technical difficulties of installing and maintaining this type of software, ultimately it is helpful in terms of knowledge acquisition and as a beneficial investment librarians can make in themselves, their libraries, and their patrons.…

Booth Library On-Line Circulation System (BLOC

Directory of Open Access Journals (Sweden)

Paladugu V. Rao

1971-06-01

Full Text Available An on-line circulation system developed at a relatively small university library demonstrates that academic libraries with limited funds can develop automated systems utilizing parent institution's computer facilities in a time-sharing mode. In operation since September 1968, using an IBM 360/50 computer and associated peripheral equipment, it provides control over all stack books.

Nanodisc-solubilized membrane protein library reflects the membrane proteome.

Science.gov (United States)

Marty, Michael T; Wilcox, Kyle C; Klein, William L; Sligar, Stephen G

2013-05-01

The isolation and identification of unknown membrane proteins offers the prospect of discovering new pharmaceutical targets and identifying key biochemical receptors. However, interactions between membrane protein targets and soluble ligands are difficult to study in vitro due to the insolubility of membrane proteins in non-detergent systems. Nanodiscs, nanoscale discoidal lipid bilayers encircled by a membrane scaffold protein belt, have proven to be an effective platform to solubilize membrane proteins and have been used to study a wide variety of purified membrane proteins. This report details the incorporation of an unbiased population of membrane proteins from Escherichia coli membranes into Nanodiscs. This solubilized membrane protein library (SMPL) forms a soluble in vitro model of the membrane proteome. Since Nanodiscs contain isolated proteins or small complexes, the SMPL is an ideal platform for interactomics studies and pull-down assays of membrane proteins. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of the protein population before and after formation of the Nanodisc library indicates that a large percentage of the proteins are incorporated into the library. Proteomic identification of several prominent bands demonstrates the successful incorporation of outer and inner membrane proteins into the Nanodisc library.

The Research Funding Service: a model for expanded library services

OpenAIRE

Means, Martha L.

2000-01-01

Traditionally, libraries have provided a modest amount of information about grants and funding opportunities to researchers in need of research funding. Ten years ago, the University of Washington (UW) Health Sciences Libraries and Information Center joined in a cooperative effort with the School of Medicine to develop a complete, library-based grant and funding service for health sciences researchers called the Research Funding Service. The library provided space, access to the library colle...

Automated design of degenerate codon libraries.

Science.gov (United States)

Mena, Marco A; Daugherty, Patrick S

2005-12-01

Degenerate codon libraries are frequently used in protein engineering and evolution studies but are often limited to targeting a small number of positions to adequately limit the search space. To mitigate this, codon degeneracy can be limited using heuristics or previous knowledge of the targeted positions. To automate design of libraries given a set of amino acid sequences, an algorithm (LibDesign) was developed that generates a set of possible degenerate codon libraries, their resulting size, and their score relative to a user-defined scoring function. A gene library of a specified size can then be constructed that is representative of the given amino acid distribution or that includes specific sequences or combinations thereof. LibDesign provides a new tool for automated design of high-quality protein libraries that more effectively harness existing sequence-structure information derived from multiple sequence alignment or computational protein design data.

An Analysis of Academic Research Libraries Assessment Data: A Look at Professional Models and Benchmarking Data

Science.gov (United States)

Lewin, Heather S.; Passonneau, Sarah M.

2012-01-01

This research provides the first review of publicly available assessment information found on Association of Research Libraries (ARL) members' websites. After providing an overarching review of benchmarking assessment data, and of professionally recommended assessment models, this paper examines if libraries contextualized their assessment…

Random small interfering RNA library screen identifies siRNAs that induce human erythroleukemia cell differentiation.

Science.gov (United States)

Fan, Cuiqing; Xiong, Yuan; Zhu, Ning; Lu, Yabin; Zhang, Jiewen; Wang, Song; Liang, Zicai; Shen, Yan; Chen, Meihong

2011-03-01

Cancers are characterized by poor differentiation. Differentiation therapy is a strategy to alleviate malignant phenotypes by inducing cancer cell differentiation. Here we carried out a combinatorial high-throughput screen with a random siRNA library on human erythroleukemia K-562 cell differentiation. Two siRNAs screened from the library were validated to be able to induce erythroid differentiation to varying degrees, determined by CD235 and globin up-regulation, GATA-2 down-regulation, and cell growth inhibition. The screen we performed here is the first trial of screening cancer differentiation-inducing agents from a random siRNA library, demonstrating that a random siRNA library can be considered as a new resource in efforts to seek new therapeutic agents for cancers. As a random siRNA library has a broad coverage for the entire genome, including known/unknown genes and protein coding/non-coding sequences, screening using a random siRNA library can be expected to greatly augment the repertoire of therapeutic siRNAs for cancers.

A case study: the evolution of a "facilitator model" liaison program in an academic medical library.

Science.gov (United States)

Crossno, Jon E; DeShay, Claudia H; Huslig, Mary Ann; Mayo, Helen G; Patridge, Emily F

2012-07-01

What type of liaison program would best utilize both librarians and other library staff to effectively promote library services and resources to campus departments? The case is an academic medical center library serving a large, diverse campus. The library implemented a "facilitator model" program to provide personalized service to targeted clients that allowed for maximum staff participation with limited subject familiarity. To determine success, details of liaison-contact interactions and results of liaison and department surveys were reviewed. Liaisons successfully recorded 595 interactions during the program's first 10 months of existence. A significant majority of departmental contact persons (82.5%) indicated they were aware of the liaison program, and 75% indicated they preferred email communication. The "facilitator model" provides a well-defined structure for assigning liaisons to departments or groups; however, training is essential to ensure that liaisons are able to communicate effectively with their clients.

The Case for Library Management Games

Science.gov (United States)

Buckland, K.; Hindle, A.

1971-01-01

In professional training of librarians, mathematical modeling can be useful in relatively sophisticated library management games if the models simulate the provision and use of library services. (33 references) (MM)

Factors Related Management Skills of High School Library Directors in the Republic of China

Directory of Open Access Journals (Sweden)

Li-ling Kuo

1999-04-01

Full Text Available

頁次：12-34

small;">This study attempted to determine the factors related to the management skills of high school library directors in Taiwan, R. o. C. There were five dimensions of the Level of Management Skills (LMS, namely, professionalism, communication, library knowledge and skills, administration, and instructional leadership. The sample size was 201 randomly selected high school library directors small;">in Taiwan. Data were collected by mail questionnaire from July to September 1996. Correlation analyses were conducted to examine the relationships between the factors of the library directors' sum of the LMS scores and independent variables. The regression equation was drawn. In the full model of the regression analysis, derived independent variables, "Support, circulation volumes, and the type of school," "Education and effort," and "Continuing professional education activities in library science" explained the greatest amount of unique variance in the dependent variable, the sum of the LMS scores. This study suggested establishing the standards of basic abilities for school library directors, arranging local unions of high school library directors in the country, re-arranging the core courses of the library majors, and emphasizing the role of "instructional consultant"

Leadership In The Public Library : Case Study In Tenteram City Public Library

Directory of Open Access Journals (Sweden)

Muhammad Irsyad Al Fatih

2018-01-01

Full Text Available In the formal and informal organization, it is always found someone who is considered more prominent than others, who then appointed or designated as a leader. The Leader of an organization is expected to have leadership qualities, which showed his skills in leading organizations. A leader in the library requires synergy between skills in library management and leadership in general in order to create a good working atmosphere and to encourage the library staff in providing the best services to the patron community. Tenteram City Public library since year of 2018 has never experienced a change of its leader. Research using qualitative approach aimed to identify the leadership of Tenteram City public library leader in developing human resources and library services. Data of this study is gathered through observation and interviews. It is found that the head of the library serves as a role model in imbedding working discipline, he never involved the staff in decision making, the fear of making mistake is the working atmosphere created in the library. The Research found that the head of Tenteram City public library adopts autocratic leadership.

Leadership In The Public Library : Case Study In Tenteram City Public Library

Directory of Open Access Journals (Sweden)

Muhammad Irsyad Alfatih

2017-06-01

In the formal and informal organization, it is always found someone who is considered more prominent than others, who then appointed or designated as a leader. The Leader of an organization is expected to have leadership qualities, which showed his skills in leading organizations. A leader in the library requires synergy between skills in library management and leadership in general in order to create a good working atmosphere and to encourage the library staff in providing the best services to the patron community. Tenteram City Public library since year of 2018 has never experienced a change of its leader. Research using qualitative approach aimed to identify the leadership of Tenteram City public library leader in developing human resources and library services. Data of this study is gathered through observation and interviews. It is found that the head of the library serves as a role model in imbedding working discipline, he never involved the staff in decision making, the fear of making mistake is the working atmosphere created in the library. The Research found that the head of Tenteram City public library adopts autocratic leadership.

TRAC Searchable Research Library

Science.gov (United States)

2016-05-01

Relational Data Modeling (VRDM) computational paradigm. VRDM has the key attributes of being cloud available, using domain semantics for configured...Figure 1. Methodology for TRAC Searchable Research Library Development. ........................... 5 Figure 2. The conceptual model for the cloud ...TRAC Searchable Research Library project was initiated by TRAC- HQ to address a current capability gap in the TRAC organization. Currently TRAC does not

CHIPMUNK: A Virtual Synthesizable Small-Molecule Library for Medicinal Chemistry, Exploitable for Protein-Protein Interaction Modulators.

Science.gov (United States)

Humbeck, Lina; Weigang, Sebastian; Schäfer, Till; Mutzel, Petra; Koch, Oliver

2018-03-20

A common issue during drug design and development is the discovery of novel scaffolds for protein targets. On the one hand the chemical space of purchasable compounds is rather limited; on the other hand artificially generated molecules suffer from a grave lack of accessibility in practice. Therefore, we generated a novel virtual library of small molecules which are synthesizable from purchasable educts, called CHIPMUNK (CHemically feasible In silico Public Molecular UNiverse Knowledge base). Altogether, CHIPMUNK covers over 95 million compounds and encompasses regions of the chemical space that are not covered by existing databases. The coverage of CHIPMUNK exceeds the chemical space spanned by the Lipinski rule of five to foster the exploration of novel and difficult target classes. The analysis of the generated property space reveals that CHIPMUNK is well suited for the design of protein-protein interaction inhibitors (PPIIs). Furthermore, a recently developed structural clustering algorithm (StruClus) for big data was used to partition the sub-libraries into meaningful subsets and assist scientists to process the large amount of data. These clustered subsets also contain the target space based on ChEMBL data which was included during clustering. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Organizational prerequisites for the preservation of library collections in monastery libraries

Directory of Open Access Journals (Sweden)

Maja Krtalić

2012-02-01

libraries. The conceptual approach to heritage preservation in monastery libraries used in this paper is based on the theoretical model of written heritage preservation management that comprises five aspects bringing together the theoretical, strategic, legal, financial, educational, operative, and cultural components. Monastery libraries are facing many problems in protection and preservation of collections. Most of their problems fall under the economic, legal, material and operative aspects of preservation. In addition to the most common limitations, such as financial constraints, inadequate premises for keeping and storing the collections, they often have staff shortages, especially of trained staff with particular knowledge and skills required to protect the collections of such libraries, which brings the educational aspect of preservation into the foreground. Even though the protection and preservation of library collections in monastery libraries is mostly the responsibility of monastery monks, their knowledge is mostly not expert enough and they cannot be the only ones made responsible for preservation. This issue needs to be considered from the strategic and theoretical aspects of written heritage preservation management. One of the major hurdles is the inadequacy of legislation and its lack of recognition of those collections as national heritage. One of the factors that needs to be taken into consideration are changes that occur in the cultural and social contexts, i.e. changes in relations between church orders and communities in which they are active. Based on the data collected and relying on the conceptual model of written heritage preservation management in the Republic of Croatia, the current state of monastery library collections preservation has been established and measures for a systematic and more efficient management of written heritage preservation in monastery libraries have been proposed.

Development and Synthesis of DNA-Encoded Benzimidazole Library.

Science.gov (United States)

Ding, Yun; Chai, Jing; Centrella, Paolo A; Gondo, Chenaimwoyo; DeLorey, Jennifer L; Clark, Matthew A

2018-04-25

Encoded library technology (ELT) is an effective approach to the discovery of novel small-molecule ligands for biological targets. A key factor for the success of the technology is the chemical diversity of the libraries. Here we report the development of DNA-conjugated benzimidazoles. Using 4-fluoro-3-nitrobenzoic acid as a key synthon, we synthesized a 320 million-member DNA-encoded benzimidazole library using Fmoc-protected amino acids, amines and aldehydes as diversity elements. Affinity selection of the library led to the discovery of a novel, potent and specific antagonist of the NK3 receptor.

High-Performance Small-Scale Solvers for Moving Horizon Estimation

DEFF Research Database (Denmark)

Frison, Gianluca; Vukov, Milan; Poulsen, Niels Kjølstad

2015-01-01

implementation techniques focusing on small-scale problems. The proposed MHE solver is implemented using custom linear algebra routines and is compared against implementations using BLAS libraries. Additionally, the MHE solver is interfaced to a code generation tool for nonlinear model predictive control (NMPC...

FilTer BaSe: A web accessible chemical database for small compound libraries.

Science.gov (United States)

Kolte, Baban S; Londhe, Sanjay R; Solanki, Bhushan R; Gacche, Rajesh N; Meshram, Rohan J

2018-03-01

Finding novel chemical agents for targeting disease associated drug targets often requires screening of large number of new chemical libraries. In silico methods are generally implemented at initial stages for virtual screening. Filtering of such compound libraries on physicochemical and substructure ground is done to ensure elimination of compounds with undesired chemical properties. Filtering procedure, is redundant, time consuming and requires efficient bioinformatics/computer manpower along with high end software involving huge capital investment that forms a major obstacle in drug discovery projects in academic setup. We present an open source resource, FilTer BaSe- a chemoinformatics platform (http://bioinfo.net.in/filterbase/) that host fully filtered, ready to use compound libraries with workable size. The resource also hosts a database that enables efficient searching the chemical space of around 348,000 compounds on the basis of physicochemical and substructure properties. Ready to use compound libraries and database presented here is expected to aid a helping hand for new drug developers and medicinal chemists. Copyright © 2017 Elsevier Inc. All rights reserved.

Atlas : A library for numerical weather prediction and climate modelling

Science.gov (United States)

Deconinck, Willem; Bauer, Peter; Diamantakis, Michail; Hamrud, Mats; Kühnlein, Christian; Maciel, Pedro; Mengaldo, Gianmarco; Quintino, Tiago; Raoult, Baudouin; Smolarkiewicz, Piotr K.; Wedi, Nils P.

2017-11-01

The algorithms underlying numerical weather prediction (NWP) and climate models that have been developed in the past few decades face an increasing challenge caused by the paradigm shift imposed by hardware vendors towards more energy-efficient devices. In order to provide a sustainable path to exascale High Performance Computing (HPC), applications become increasingly restricted by energy consumption. As a result, the emerging diverse and complex hardware solutions have a large impact on the programming models traditionally used in NWP software, triggering a rethink of design choices for future massively parallel software frameworks. In this paper, we present Atlas, a new software library that is currently being developed at the European Centre for Medium-Range Weather Forecasts (ECMWF), with the scope of handling data structures required for NWP applications in a flexible and massively parallel way. Atlas provides a versatile framework for the future development of efficient NWP and climate applications on emerging HPC architectures. The applications range from full Earth system models, to specific tools required for post-processing weather forecast products. The Atlas library thus constitutes a step towards affordable exascale high-performance simulations by providing the necessary abstractions that facilitate the application in heterogeneous HPC environments by promoting the co-design of NWP algorithms with the underlying hardware.

Strategy to discover diverse optimal molecules in the small molecule universe.

Science.gov (United States)

Rupakheti, Chetan; Virshup, Aaron; Yang, Weitao; Beratan, David N

2015-03-23

The small molecule universe (SMU) is defined as a set of over 10(60) synthetically feasible organic molecules with molecular weight less than ∼500 Da. Exhaustive enumerations and evaluation of all SMU molecules for the purpose of discovering favorable structures is impossible. We take a stochastic approach and extend the ACSESS framework ( Virshup et al. J. Am. Chem. Soc. 2013 , 135 , 7296 - 7303 ) to develop diversity oriented molecular libraries that can generate a set of compounds that is representative of the small molecule universe and that also biases the library toward favorable physical property values. We show that the approach is efficient compared to exhaustive enumeration and to existing evolutionary algorithms for generating such libraries by testing in the NKp fitness landscape model and in the fully enumerated GDB-9 chemical universe containing 3 × 10(5) molecules.

Construction of high quality Gateway™ entry libraries and their application to yeast two-hybrid for the monocot model plant Brachypodium distachyon

Directory of Open Access Journals (Sweden)

Kumimoto Roderick W

2011-05-01

Full Text Available Abstract Background Monocots, especially the temperate grasses, represent some of the most agriculturally important crops for both current food needs and future biofuel development. Because most of the agriculturally important grass species are difficult to study (e.g., they often have large, repetitive genomes and can be difficult to grow in laboratory settings, developing genetically tractable model systems is essential. Brachypodium distachyon (hereafter Brachypodium is an emerging model system for the temperate grasses. To fully realize the potential of this model system, publicly accessible discovery tools are essential. High quality cDNA libraries that can be readily adapted for multiple downstream purposes are a needed resource. Additionally, yeast two-hybrid (Y2H libraries are an important discovery tool for protein-protein interactions and are not currently available for Brachypodium. Results We describe the creation of two high quality, publicly available Gateway™ cDNA entry libraries and their derived Y2H libraries for Brachypodium. The first entry library represents cloned cDNA populations from both short day (SD, 8/16-h light/dark and long day (LD, 20/4-h light/dark grown plants, while the second library was generated from hormone treated tissues. Both libraries have extensive genome coverage (~5 × 107 primary clones each and average clone lengths of ~1.5 Kb. These entry libraries were then used to create two recombination-derived Y2H libraries. Initial proof-of-concept screens demonstrated that a protein with known interaction partners could readily re-isolate those partners, as well as novel interactors. Conclusions Accessible community resources are a hallmark of successful biological model systems. Brachypodium has the potential to be a broadly useful model system for the grasses, but still requires many of these resources. The Gateway™ compatible entry libraries created here will facilitate studies for multiple user

Electronic Libraries and the Future:Implications for Academic Libraries with East Asian Collections

Directory of Open Access Journals (Sweden)

Zhijia Shen、Susan Anthes

2000-04-01

Full Text Available

頁次：4-17

small;">Academic libraries are stepping into uncharted territories with the advent of electronic books (ebooks and electronic libraries. This article provides an overview of the current status of both electronic books and libraries, including a description of a beta test of a new service netLibrary(tm at the University of Colorado at Boulder. Possible implications of new technology for various aspects of academic librarianship in the areas of acquisition, collection development, preservation, reference, circulation, interlibrary loan, and cataloging are discussed. Particular reference is given to East Asian collections. Benefits as well as liabilities are discussed. The authors raise issues regarding the potential of the new technology, and speculate on possible trends and areas for future research for academic librarians.

The Library as a mediator for e-publishing

DEFF Research Database (Denmark)

Elbæk, Mikael Karstensen; Nondal, Lars

2007-01-01

business model (i.e. finances!) that doesn't encourage an open access publishing strategy. The Copenhagen Business School (CBS) Library provides a low risk environment for small journals related to the business school to make a gradual transition to e-publishing/e-archiving. Whether they at a later stage...... take the full step towards open access publishing remains to be seen. It is our firm belief that this gradual transition is essential for these smaller journals to eventually arrive online at all....

The OPL Sourcebook: A Guide for Solo and Small Libraries.

Science.gov (United States)

Siess, Judith A.

Taking an international approach to reflect the growing number of one-person libraries (OPLs) worldwide, this handbook and directory for OPLs covers organizational culture, customer service, time management and planning, budgeting, accounting, technology, collection development, education, downsizing, outsourcing, and many other key management…

Application Design Library With gamification concept

Directory of Open Access Journals (Sweden)

Nisaul Barokati

2017-03-01

Full Text Available The library is an effort to maintain and improve the efficiency and effectiveness of the learning process. Various means have been used to enhance the library's role in community development. One way is to develop a concept and a different orientation in the management system or the library. The concept in question is gamification. Gamification is a process with the aim of changing jobs or activities that usually go tedious and less enjoyable to be more interesting and fun to do. One approach taken is to reward both virtual and non-virtual that can increase people's motivation to do something, in this case, is to visit and take advantage of the functions and library facilities. This research resulted in a model that features a library application with the concept of gamification. The model can be implemented into an application that will increase visits and activities at the library. Thus the function and the main purpose of the library be met..

The academic library network

Directory of Open Access Journals (Sweden)

Jacek Wojciechowski

2012-01-01

Full Text Available The efficiency of libraries, academic libraries in particular, necessitates organizational changes facilitating or even imposing co-operation. Any structure of any university has to have an integrated network of libraries, with an appropriate division of work, and one that is consolidated as much as it is possible into medium-size or large libraries. Within thus created network, a chance arises to centralize the main library processes based on appropriate procedures in the main library, highly specialized, more effective and therefore cheaper in operation, including a co-ordination of all more important endeavours and tasks. Hierarchically subordinated libraries can be thus more focused on performing their routine service, more and more frequently providing for the whole of the university, and being able to adjust to changeable requirements and demands of patrons and of new tasks resulting from the new model of the university operation. Another necessary change seems to be a universal implementation of an ov rall programme framework that would include all services in the university’s library networks.

PNet: A Python Library for Petri Net Modeling and Simulation

OpenAIRE

Zhu En Chay; Bing Feng Goh; Maurice HT Ling

2016-01-01

Petri Net is a formalism to describe changes between 2 or more states across discrete time and has been used to model many systems. We present PNet – a pure Python library for Petri Net modeling and simulation in Python programming language. The design of PNet focuses on reducing the learning curve needed to define a Petri Net by using a text-based language rather than programming constructs to define transition rules. Complex transition rules can be refined as regular Python functions. To de...

STAR Library Education Network: a hands-on learning program for libraries and their communities

Science.gov (United States)

Dusenbery, P.

2010-12-01

Science and technology are widely recognized as major drivers of innovation and industry (e.g. Rising above the Gathering Storm, 2006). While the focus for education reform is on school improvement, there is considerable research that supports the role that out-of-school experiences can play in student achievement and public understanding of STEM disciplines. Libraries provide an untapped resource for engaging underserved youth and their families in fostering an appreciation and deeper understanding of science and technology topics. Designed spaces, like libraries, allow lifelong, life-wide, and life-deep learning to take place though the research basis for learning in libraries is not as developed as other informal settings like science centers. The Space Science Institute’s National Center for Interactive Learning (NCIL) in partnership with the American Library Association (ALA), the Lunar and Planetary Institute (LPI), and the National Girls Collaborative Project (NGCP) have received funding from NSF to develop a national education project called the STAR Library Education Network: a hands-on learning program for libraries and their communities (or STAR-Net for short). STAR stands for Science-Technology, Activities and Resources. The overarching goal of the project is to reach underserved youth and their families with informal STEM learning experiences. This project will deepen our knowledge of informal/lifelong learning that takes place in libraries and establish a learning model that can be compared to the more established free-choice learning model for science centers and museums. The project includes the development of two STEM hands-on exhibits on topics that are of interest to library staff and their patrons: Discover Earth and Discover Tech. In addition, the project will produce resources and inquiry-based activities that libraries can use to enrich the exhibit experience. Additional resources will be provided through partnerships with relevant

Update on Small Modular Reactors Dynamics System Modeling Tool -- Molten Salt Cooled Architecture

Energy Technology Data Exchange (ETDEWEB)

Hale, Richard Edward [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Cetiner, Sacit M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Fugate, David L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Qualls, A L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Borum, Robert C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Chaleff, Ethan S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Rogerson, Doug W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Batteh, John J. [Modelon Corporation (Sweden); Tiller, Michael M. [Xogeny Corporation, Canton, MI (United States)

2014-08-01

The Small Modular Reactor (SMR) Dynamic System Modeling Tool project is in the third year of development. The project is designed to support collaborative modeling and study of various advanced SMR (non-light water cooled) concepts, including the use of multiple coupled reactors at a single site. The objective of the project is to provide a common simulation environment and baseline modeling resources to facilitate rapid development of dynamic advanced reactor SMR models, ensure consistency among research products within the Instrumentation, Controls, and Human-Machine Interface (ICHMI) technical area, and leverage cross-cutting capabilities while minimizing duplication of effort. The combined simulation environment and suite of models are identified as the Modular Dynamic SIMulation (MoDSIM) tool. The critical elements of this effort include (1) defining a standardized, common simulation environment that can be applied throughout the program, (2) developing a library of baseline component modules that can be assembled into full plant models using existing geometry and thermal-hydraulic data, (3) defining modeling conventions for interconnecting component models, and (4) establishing user interfaces and support tools to facilitate simulation development (i.e., configuration and parameterization), execution, and results display and capture.

Structure-Based Virtual Screening of Commercially Available Compound Libraries.

Science.gov (United States)

Kireev, Dmitri

2016-01-01

Virtual screening (VS) is an efficient hit-finding tool. Its distinctive strength is that it allows one to screen compound libraries that are not available in the lab. Moreover, structure-based (SB) VS also enables an understanding of how the hit compounds bind the protein target, thus laying ground work for the rational hit-to-lead progression. SBVS requires a very limited experimental effort and is particularly well suited for academic labs and small biotech companies that, unlike pharmaceutical companies, do not have physical access to quality small-molecule libraries. Here, we describe SBVS of commercial compound libraries for Mer kinase inhibitors. The screening protocol relies on the docking algorithm Glide complemented by a post-docking filter based on structural protein-ligand interaction fingerprints (SPLIF).

A structured model library for the analysis of electric-vehicle drivetrains; Eine strukturierte Modellbibliothek fuer Analysen an Antriebsstraengen von Elektrofahrzeugen

Energy Technology Data Exchange (ETDEWEB)

Niedzwiedz, Simon; Frei, Stephan [Technische Univ. Dortmund (Germany). AG Bordsysteme

2012-11-01

This contribution presents a concept for developing structured simulation model libraries. The main objectives are securing a reliable functionality of the contained models among each other and meeting the requirements that a model library has to be flexible and easy to manage on one side, while it has to define a comprehensible and distinct order on the other side. These qualities are especially important in bigger or distributed working groups, for ensuring a long-term and efficient usability. For model reusability and continuous further development a consistent structuring is essential. This concept will be exemplified through a structured model library for the analysis of electric-vehicle drivetrains. (orig.)

Cloud Computing and Your Library

Science.gov (United States)

Mitchell, Erik T.

2010-01-01

One of the first big shifts in how libraries manage resources was the move from print-journal purchasing models to database-subscription and electronic-journal purchasing models. Libraries found that this transition helped them scale their resources and provide better service just by thinking a bit differently about their services. Likewise,…

Update on Small Modular Reactors Dynamic System Modeling Tool: Web Application

International Nuclear Information System (INIS)

Hale, Richard Edward; Cetiner, Sacit M.; Fugate, David L.; Batteh, John J; Tiller, Michael M.

2015-01-01

Previous reports focused on the development of component and system models as well as end-to-end system models using Modelica and Dymola for two advanced reactor architectures: (1) Advanced Liquid Metal Reactor and (2) fluoride high-temperature reactor (FHR). The focus of this report is the release of the first beta version of the web-based application for model use and collaboration, as well as an update on the FHR model. The web-based application allows novice users to configure end-to-end system models from preconfigured choices to investigate the instrumentation and controls implications of these designs and allows for the collaborative development of individual component models that can be benchmarked against test systems for potential inclusion in the model library. A description of this application is provided along with examples of its use and a listing and discussion of all the models that currently exist in the library.

Recent Developments in Cambridge College Libraries

Directory of Open Access Journals (Sweden)

Alison Wilson

2006-07-01

Full Text Available Cambridge University has three tiers of libraries available to students: the University Library, departmental (subject libraries and college libraries. Over the past thirty years there has been increasing pressure on the colleges to provide more books, reader places and technical resources in their libraries, with the result that a number of new library buildings, of very different styles, have been opened. Other colleges have opted for refurbishment and extension of existing libraries. These libraries are small (30-100,000 books and intimate, often open 24 hours a day and with generous provision for lending books. Great importance is placed on keeping them at the heart of the college. Challenges for architects are the sensitive sites, restrictions on changes to listed buildings, and the limited space available. The constricted sites cause difficulties for the builders too. I will consider some solutions to these problems with reference to projects in four colleges: Pembroke, Peterhouse, Corpus Christi and Newnham. At Pembroke architects Freeland Rees Roberts have built an extension to a listed building and at Peterhouse they have adapted an adjoining room. Corpus Christi is moving its library to a Victorian building which has been internally redesigned by Wright + Wright. Newnham demolished a 1960s extension in order to develop the plot more efficiently to a design by John Miller + Partners. All the architects have shown sensitivity to the needs of their clients and ingenuity in making intensive use of limited space.

Campus Partner Collections: Expanding the Boundaries of the Library

Science.gov (United States)

Elguindi, Anne C.; Kelshian, Robert; Sandler, Alayne Mundt

2011-01-01

At most colleges and universities, there are a number of small, nonlibrary collections across campus, such as those found in student centers or academic departments. Historically, at American University, partnership with these collections was done through absorbing them into the main library collection. Recently, however, the Library has seen…

MpTheory Java library: a multi-platform Java library for systems biology based on the Metabolic P theory.

Science.gov (United States)

Marchetti, Luca; Manca, Vincenzo

2015-04-15

MpTheory Java library is an open-source project collecting a set of objects and algorithms for modeling observed dynamics by means of the Metabolic P (MP) theory, that is, a mathematical theory introduced in 2004 for modeling biological dynamics. By means of the library, it is possible to model biological systems both at continuous and at discrete time. Moreover, the library comprises a set of regression algorithms for inferring MP models starting from time series of observations. To enhance the modeling experience, beside a pure Java usage, the library can be directly used within the most popular computing environments, such as MATLAB, GNU Octave, Mathematica and R. The library is open-source and licensed under the GNU Lesser General Public License (LGPL) Version 3.0. Source code, binaries and complete documentation are available at http://mptheory.scienze.univr.it. luca.marchetti@univr.it, marchetti@cosbi.eu Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

The Planetary Terrestrial Analogues Library (PTAL)

Science.gov (United States)

Werner, S. C.; Dypvik, H.; Poulet, F.; Rull Perez, F.; Bibring, J.-P.; Bultel, B.; Casanova Roque, C.; Carter, J.; Cousin, A.; Guzman, A.; Hamm, V.; Hellevang, H.; Lantz, C.; Lopez-Reyes, G.; Manrique, J. A.; Maurice, S.; Medina Garcia, J.; Navarro, R.; Negro, J. I.; Neumann, E. R.; Pilorget, C.; Riu, L.; Sætre, C.; Sansano Caramazana, A.; Sanz Arranz, A.; Sobron Grañón, F.; Veneranda, M.; Viennet, J.-C.; PTAL Team

2018-04-01

The Planetary Terrestrial Analogues Library project aims to build and exploit a spectral data base for the characterisation of the mineralogical and geological evolution of terrestrial planets and small solar system bodies.

Modeling of Heat Transfer in Rooms in the Modelica "Buildings" Library

Energy Technology Data Exchange (ETDEWEB)

Wetter, Michael [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Zuo, Wangda [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Nouidui, Thierry Stephane [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

2011-11-01

This paper describes the implementation of the room heat transfer model in the free open-source Modelica \\Buildings" library. The model can be used as a single room or to compose a multizone building model. We discuss how the model is decomposed into submodels for the individual heat transfer phenomena. We also discuss the main physical assumptions. The room model can be parameterized to use different modeling assumptions, leading to linear or non-linear differential algebraic systems of equations. We present numerical experiments that show how these assumptions affect computing time and accuracy for selected cases of the ANSI/ASHRAE Standard 140- 2007 envelop validation tests.

Mass Digitisation by Libraries: Issues concerning Organisation, Quality and Efficiency

Directory of Open Access Journals (Sweden)

Astrid Verheusen

2008-03-01

Full Text Available Ever since the world-wide web made it possible to display graphics on the Internet, libraries have been scanning their older documents and pictures to provide access to them. From the middle of the 1990s thousands of libraries of all sizes began scanning parts of their collections, provided these with metadata and made them available on the web. The emphasis in these first, rather small, digitisation projects was on experimenting with different techniques for both scanning and building interfaces for the Internet. Along the way, methods for quality assurance, project management and business models became more professional. In line with the progress made in the field of digitisation, a profound knowledge of best practices has been developed. However, this knowledge is not available for all cultural heritage institutions who want to digitise their collections. Most of the smaller institutions lack experience and, moreover, the means to digitise in an efficient way. At the same time, the larger libraries are moving towards large-scale digitisation of historical texts while Google has already digitised millions of books from several libraries around the world. Although many libraries welcome the unprecedented access to all this information, Google has also been criticized for the inferior quality of their images, the emphasis on the English language, the violation of copyright laws and the lack of attention for preservation issues. The question therefore arises: can libraries do better than Google?

Library Space: Assessment and Planning through a Space Utilization Study.

Science.gov (United States)

Prentice, Katherine A; Argyropoulos, Erica K

2018-01-01

The objective of this article is to describe the recent space and furniture utilization study conducted through direct observation at the small, academic-centered Schusterman Library. Student workers from the library's reference desk monitored two semesters of use and went on to observe a third semester after electrical power upgrades were installed. Extensive use details were collected about where library patrons sat during which parts of the day, and certain areas of the library were ultimately identified as much more active than others. Overall, the information gathered proved useful to library planning and will be valuable to future space initiatives. This article further demonstrates feasible means for any library to implement a similar study with minimal resources.

About the Library - Betty Petersen Memorial Library

Science.gov (United States)

branch library of the NOAA Central Library. The library serves the NOAA Science Center in Camp Springs , Maryland. History and Mission: Betty Petersen Memorial Library began as a reading room in the NOAA Science Science Center staff and advises the library on all aspects of the library program. Library Newsletters

Evaluation of an FDA approved library against laboratory models of human intestinal nematode infections.

Science.gov (United States)

Keiser, Jennifer; Panic, Gordana; Adelfio, Roberto; Cowan, Noemi; Vargas, Mireille; Scandale, Ivan

2016-07-01

Treatment options for infections with soil-transmitted helminths (STH) - Ascaris lumbricoides, Trichuris trichiura and the two hookworm species, Ancylostoma duodenale and Necator americanus - are limited despite their considerable global health burden. The aim of the present study was to test the activity of an openly available FDA library against laboratory models of human intestinal nematode infections. All 1,600 drugs were first screened against Ancylostoma ceylanicum third-stage larvae (L3). Active compounds were scrutinized and toxic compounds, drugs indicated solely for topical use, and already well-studied anthelmintics were excluded. The remaining hit compounds were tested in parallel against Trichuris muris first-stage larvae (L1), Heligmosomoides polygyrus third-stage larvae (L3), and adult stages of the three species in vitro. In vivo studies were performed in the H. polygyrus and T. muris mice models. Fifty-four of the 1,600 compounds tested revealed an activity of > 60 % against A. ceylanicum L3 (hit rate of 3.4 %), following incubation at 200 μM for 72 h. Twelve compounds progressed into further screens. Adult A. ceylanicum were the least affected (1/12 compounds active at 50 μM), while eight of the 12 test compounds revealed activity against T. muris L1 (100 μM) and adults (50 μM), and H. polygyrus L3 (200 μM). Trichlorfon was the only compound active against all stages of A. ceylanicum, H. polygyrus and T. muris. In addition, trichlorfon achieved high worm burden reductions of 80.1 and 98.9 %, following a single oral dose of 200 mg/kg in the T. muris and H. polygyrus mouse model, respectively. Drug screening on the larval stages of intestinal parasitic nematodes is feasible using small libraries and important given the empty drug discovery and development pipeline for STH infections. Differences and commonalities in drug activities across the different STH species and stages were confirmed. Hits identified might serve as a

CHEMICAL EVOLUTION LIBRARY FOR GALAXY FORMATION SIMULATION

International Nuclear Information System (INIS)

Saitoh, Takayuki R.

2017-01-01

We have developed a software library for chemical evolution simulations of galaxy formation under the simple stellar population (SSP) approximation. In this library, all of the necessary components concerning chemical evolution, such as initial mass functions, stellar lifetimes, yields from Type II and Type Ia supernovae, asymptotic giant branch stars, and neutron star mergers, are compiled from the literature. Various models are pre-implemented in this library so that users can choose their favorite combination of models. Subroutines of this library return released energy and masses of individual elements depending on a given event type. Since the redistribution manner of these quantities depends on the implementation of users’ simulation codes, this library leaves it up to the simulation code. As demonstrations, we carry out both one-zone, closed-box simulations and 3D simulations of a collapsing gas and dark matter system using this library. In these simulations, we can easily compare the impact of individual models on the chemical evolution of galaxies, just by changing the control flags and parameters of the library. Since this library only deals with the part of chemical evolution under the SSP approximation, any simulation codes that use the SSP approximation—namely, particle-base and mesh codes, as well as semianalytical models—can use it. This library is named “CELib” after the term “Chemical Evolution Library” and is made available to the community.

CHEMICAL EVOLUTION LIBRARY FOR GALAXY FORMATION SIMULATION

Energy Technology Data Exchange (ETDEWEB)

Saitoh, Takayuki R., E-mail: saitoh@elsi.jp [Earth-Life Science Institute, Tokyo Institute of Technology, 2-12-1, Ookayama, Meguro, Tokyo, 152-8551 (Japan)

2017-02-01

We have developed a software library for chemical evolution simulations of galaxy formation under the simple stellar population (SSP) approximation. In this library, all of the necessary components concerning chemical evolution, such as initial mass functions, stellar lifetimes, yields from Type II and Type Ia supernovae, asymptotic giant branch stars, and neutron star mergers, are compiled from the literature. Various models are pre-implemented in this library so that users can choose their favorite combination of models. Subroutines of this library return released energy and masses of individual elements depending on a given event type. Since the redistribution manner of these quantities depends on the implementation of users’ simulation codes, this library leaves it up to the simulation code. As demonstrations, we carry out both one-zone, closed-box simulations and 3D simulations of a collapsing gas and dark matter system using this library. In these simulations, we can easily compare the impact of individual models on the chemical evolution of galaxies, just by changing the control flags and parameters of the library. Since this library only deals with the part of chemical evolution under the SSP approximation, any simulation codes that use the SSP approximation—namely, particle-base and mesh codes, as well as semianalytical models—can use it. This library is named “CELib” after the term “Chemical Evolution Library” and is made available to the community.

Encoded libraries of chemically modified peptides.

Science.gov (United States)

Heinis, Christian; Winter, Greg

2015-06-01

The use of powerful technologies for generating and screening DNA-encoded protein libraries has helped drive the development of proteins as pharmaceutical ligands. However the development of peptides as pharmaceutical ligands has been more limited. Although encoded peptide libraries are typically several orders of magnitude larger than classical chemical libraries, can be more readily screened, and can give rise to higher affinity ligands, their use as pharmaceutical ligands is limited by their intrinsic properties. Two of the intrinsic limitations include the rotational flexibility of the peptide backbone and the limited number (20) of natural amino acids. However these limitations can be overcome by use of chemical modification. For example, the libraries can be modified to introduce topological constraints such as cyclization linkers, or to introduce new chemical entities such as small molecule ligands, fluorophores and photo-switchable compounds. This article reviews the chemistry involved, the properties of the peptide ligands, and the new opportunities offered by chemical modification of DNA-encoded peptide libraries. Copyright © 2015. Published by Elsevier Ltd.

A model library for simulation and benchmarking of integrated urban wastewater systems

DEFF Research Database (Denmark)

Saagi, R.; Flores Alsina, Xavier; Kroll, J. S.

2017-01-01

This paper presents a freely distributed, open-source toolbox to predict the behaviour of urban wastewater systems (UWS). The proposed library is used to develop a system-wide Benchmark Simulation Model (BSM-UWS) for evaluating (local/global) control strategies in urban wastewater systems (UWS...

America's Star Libraries, 2010: Top-Rated Libraries

Science.gov (United States)

Lyons, Ray; Lance, Keith Curry

2010-01-01

The "LJ" Index of Public Library Service 2010, "Library Journal"'s national rating of public libraries, identifies 258 "star" libraries. Created by Ray Lyons and Keith Curry Lance, and based on 2008 data from the IMLS, it rates 7,407 public libraries. The top libraries in each group get five, four, or three stars. All included libraries, stars or…

OpenIPSL: Open-Instance Power System Library - Update 1.5 to "iTesla Power Systems Library (iPSL): A Modelica library for phasor time-domain simulations"

Science.gov (United States)

Baudette, Maxime; Castro, Marcelo; Rabuzin, Tin; Lavenius, Jan; Bogodorova, Tetiana; Vanfretti, Luigi

2018-01-01

This paper presents the latest improvements implemented in the Open-Instance Power System Library (OpenIPSL). The OpenIPSL is a fork from the original iTesla Power Systems Library (iPSL) by some of the original developers of the iPSL. This fork's motivation comes from the will of the authors to further develop the library with additional features tailored to research and teaching purposes. The enhancements include improvements to existing models, the addition of a new package of three phase models, and the implementation of automated tests through continuous integration.

Featured Library: Parrish Library

OpenAIRE

Kirkwood, Hal P, Jr

2015-01-01

The Roland G. Parrish Library of Management & Economics is located within the Krannert School of Management at Purdue University. Between 2005 - 2007 work was completed on a white paper that focused on a student-centered vision for the Management & Economics Library. The next step was a massive collection reduction and a re-envisioning of both the services and space of the library. Thus began a 3 phase renovation from a 2 floor standard, collection-focused library into a single floor, 18,000s...

SRADLIB: A C Library for Solar Radiation Modelling

Energy Technology Data Exchange (ETDEWEB)

Balenzategui, J. L. [Ciemat. Madrid (Spain)

2000-07-01

This document shows the result of an exhaustive study about the theoretical and numerical models available in the literature about solar radiation modelling. The purpose of this study is to develop or adapt mathematical models describing the solar radiation specifically for Spain locations as well as to create computer tools able to support the labour of researchers or engineers needing solar radiation data to solve or improve the technical or energetic performance of solar systems. As results of this study and revision, a C library (SRADLIB) is presented as a key for the compilation of the mathematical models from different authors, for the comparison among the different approaches and for its application in computer programs. Different topics related to solar radiation and its modelling are first discussed, including the assumptions and conventions adopted and describing the most accepted and used current state-of-the-art models. some typical problems in the numerical calculation of radiation values are also posed with the proposed solution. The document includes next a complete reference of the developed functions, with many examples of application and calculus. (Author) 24 refs.

SRADLIB: A C Library for Solar Radiation Modelling

International Nuclear Information System (INIS)

Balenzategui, J. L.

1999-01-01

This document shows the result of an exhaustive study about the theoretical and numerical models available in the literature about solar radiation modelling. The purpose of this study is to develop or adapt mathematical models describing the solar radiation specifically for Spain locations as well as to create computer tools able to support the labour of researchers or engineers needing solar radiation data to solve or improve the technical or energetic performance of solar systems. As result of this study and revision, a C library (SRADLIB) is presented as a key tool for the compilation of the mathematical models from different authors, for the comparison among the different approaches and for its application in computer programs. Different topics related to solar radiation and its modelling are first discussed, including the assumptions and conventions adopted and describing the most accepted and used current state-of-the-art models. Some typical problems in the numerical calculation of radiation values are also posed with the proposed solution. The document includes next a complete reference of the developed functions, with many examples of application and calculus. (Author) 24 refs

National Strategies for Public Library Development

DEFF Research Database (Denmark)

Kann-Christensen, Nanna

2010-01-01

policies on the local level are discussed. according to the national goals and cultural policies for libraries. This is done in order to point towards a possible relationship between the political means and ends regarding library development. The two models to be discussed are the systems practiced...... by The Danish Agency for Libraries and Media, and The Swedish Arts Council, who both administer development grants to public libraries. The paper identifies both differences and similarities in both the means to (the political agendas) and the objectives of governmental influence in the libraries.......The economic rationale of New Public Management (NPM) is used in both Sweden and Denmark in order to employ the national cultural policies in local development projects. The paper discusses two different organizational models that are used in order for the national level to be able to exercise...

Multigroup cross section library; WIMS library

International Nuclear Information System (INIS)

Kannan, Umasankari

2000-01-01

The WIMS library has been extensively used in thermal reactor calculations. This multigroup constants library was originally developed from the UKNDL in the late 60's and has been updated in 1986. This library has been distributed with the WIMS-D code by NEA data bank. The references to WIMS library in literature are the 'old' which is the original as developed by the AEA Winfrith and the 'new' which is the current 1986 WIMS library. IAEA has organised a CRP where a new and fully updated WIMS library will soon be available. This paper gives an overview of the definitions of the group constants that go into any basic nuclear data library used for reactor calculations. This paper also outlines the contents of the WIMS library and some of its shortcomings

Interlibrary loan in primary access libraries: challenging the traditional view.

Science.gov (United States)

Dudden, R F; Coldren, S; Condon, J E; Katsh, S; Reiter, C M; Roth, P L

2000-10-01

Primary access libraries serve as the foundation of the National Network of Libraries of Medicine (NN/LM) interlibrary loan (ILL) hierarchy, yet few published reports directly address the important role these libraries play in the ILL system. This may reflect the traditional view that small, primary access libraries are largely users of ILL, rather than important contributors to the effectiveness and efficiency of the national ILL system. This study was undertaken to test several commonly held beliefs regarding ILL system use by primary access libraries. Three hypotheses were developed. HI: Colorado and Wyoming primary access libraries comply with the recommended ILL guideline of adhering to a hierarchical structure, emphasizing local borrowing. H2: The closures of two Colorado Council of Medical Librarians (CCML) primary access libraries in 1996 resulted in twenty-three Colorado primary access libraries' borrowing more from their state resource library in 1997. H3: The number of subscriptions held by Colorado and Wyoming primary access libraries is positively correlated with the number of items they loan and negatively correlated with the number of items they borrow. The hypotheses were tested using the 1992 and 1997 DOCLINE and OCLC data of fifty-four health sciences libraries, including fifty primary access libraries, two state resource libraries, and two general academic libraries in Colorado and Wyoming. The ILL data were obtained electronically and analyzed using Microsoft Word 98, Microsoft Excel 98, and JMP 3.2.2. CCML primary access libraries comply with the recommended guideline to emphasize local borrowing by supplying each other with the majority of their ILLs, instead of overburdening libraries located at higher levels in the ILL hierarchy (H1). The closures of two CCML primary access libraries appear to have affected the entire ILL system, resulting in a greater volume of ILL activity for the state resource library and other DOCLINE libraries higher

Research evaluation support services in biomedical libraries.

Science.gov (United States)

Gutzman, Karen Elizabeth; Bales, Michael E; Belter, Christopher W; Chambers, Thane; Chan, Liza; Holmes, Kristi L; Lu, Ya-Ling; Palmer, Lisa A; Reznik-Zellen, Rebecca C; Sarli, Cathy C; Suiter, Amy M; Wheeler, Terrie R

2018-01-01

The paper provides a review of current practices related to evaluation support services reported by seven biomedical and research libraries. A group of seven libraries from the United States and Canada described their experiences with establishing evaluation support services at their libraries. A questionnaire was distributed among the libraries to elicit information as to program development, service and staffing models, campus partnerships, training, products such as tools and reports, and resources used for evaluation support services. The libraries also reported interesting projects, lessons learned, and future plans. The seven libraries profiled in this paper report a variety of service models in providing evaluation support services to meet the needs of campus stakeholders. The service models range from research center cores, partnerships with research groups, and library programs with staff dedicated to evaluation support services. A variety of products and services were described such as an automated tool to develop rank-based metrics, consultation on appropriate metrics to use for evaluation, customized publication and citation reports, resource guides, classes and training, and others. Implementing these services has allowed the libraries to expand their roles on campus and to contribute more directly to the research missions of their institutions. Libraries can leverage a variety of evaluation support services as an opportunity to successfully meet an array of challenges confronting the biomedical research community, including robust efforts to report and demonstrate tangible and meaningful outcomes of biomedical research and clinical care. These services represent a transformative direction that can be emulated by other biomedical and research libraries.

Rock.XML - Towards a library of rock physics models

Science.gov (United States)

Jensen, Erling Hugo; Hauge, Ragnar; Ulvmoen, Marit; Johansen, Tor Arne; Drottning, Åsmund

2016-08-01

Rock physics modelling provides tools for correlating physical properties of rocks and their constituents to the geophysical observations we measure on a larger scale. Many different theoretical and empirical models exist, to cover the range of different types of rocks. However, upon reviewing these, we see that they are all built around a few main concepts. Based on this observation, we propose a format for digitally storing the specifications for rock physics models which we have named Rock.XML. It does not only contain data about the various constituents, but also the theories and how they are used to combine these building blocks to make a representative model for a particular rock. The format is based on the Extensible Markup Language XML, making it flexible enough to handle complex models as well as scalable towards extending it with new theories and models. This technology has great advantages as far as documenting and exchanging models in an unambiguous way between people and between software. Rock.XML can become a platform for creating a library of rock physics models; making them more accessible to everyone.

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.

Science.gov (United States)

Germain, Andrew R; Carmody, Leigh C; Nag, Partha P; Morgan, Barbara; Verplank, Lynn; Fernandez, Cristina; Donckele, Etienne; Feng, Yuxiong; Perez, Jose R; Dandapani, Sivaraman; Palmer, Michelle; Lander, Eric S; Gupta, Piyush B; Schreiber, Stuart L; Munoz, Benito

2013-03-15

A high-throughput screen (HTS) was conducted against stably propagated cancer stem cell (CSC)-enriched populations using a library of 300,718 compounds from the National Institutes of Health (NIH) Molecular Libraries Small Molecule Repository (MLSMR). A cinnamide analog displayed greater than 20-fold selective inhibition of the breast CSC-like cell line (HMLE_sh_Ecad) over the isogenic control cell line (HMLE_sh_eGFP). Herein, we report structure-activity relationships of this class of cinnamides for selective lethality towards CSC-enriched populations. Copyright © 2013. Published by Elsevier Ltd.

University Library Strategy Development: A Conceptual Model of Researcher Performance to Inform Service Delivery

Science.gov (United States)

Maddox, Alexia; Zhao, Linlin

2017-01-01

This case study presents a conceptual model of researcher performance developed by Deakin University Library, Australia. The model aims to organize research performance data into meaningful researcher profiles, referred to as researcher typologies, which support the demonstration of research impact and value. Three dimensions shaping researcher…

Implementing portal functionality at Wageningen UR Library : combining the old with the new

NARCIS (Netherlands)

Loman, M.E.; Gerritsma, W.

2003-01-01

Library Wageningen UR is a relatively small, but highly specialized academic library serving a population of about 5900 researchers and 4700 students in the life sciences. To better serve the needs of our users portal functionality has been introduced gradually to our Desktop Library. A beginning

Model for Sucker-Rod Pumping Unit Operating Modes Analysis Based on SimMechanics Library

Science.gov (United States)

Zyuzev, A. M.; Bubnov, M. V.

2018-01-01

The article provides basic information about the process of a sucker-rod pumping unit (SRPU) model developing by means of SimMechanics library in the MATLAB Simulink environment. The model is designed for the development of a pump productivity optimal management algorithms, sensorless diagnostics of the plunger pump and pumpjack, acquisition of the dynamometer card and determination of a dynamic fluid level in the well, normalization of the faulty unit operation before troubleshooting is performed by staff as well as equilibrium ratio determining by energy indicators and outputting of manual balancing recommendations to achieve optimal power consumption efficiency. Particular attention is given to the application of various blocks from SimMechanics library to take into account the pumpjack construction principal characteristic and to obtain an adequate model. The article explains in depth the developed tools features for collecting and analysis of simulated mechanism data. The conclusions were drawn about practical implementation possibility of the SRPU modelling results and areas for further development of investigation.

Programming for adults a guide for small- and medium-sized libraries

CERN Document Server

Ranier, Raymond

2005-01-01

This book addresses all aspects of the programming process, from idea to execution, from crafts and entertainment to film, arts and science. Included are sources of funding, contracts and agreements, programming to meet the library's mission, and program evaluation.

Wayfinding Research in Library and Information Studies: State of the Field

Directory of Open Access Journals (Sweden)

Lauren H. Mandel

2017-06-01

Full Text Available Abstract Objective – Often people enter libraries focused on their primary information needs and haven't considered their need for spatial information to find their way to what they need. This presents unique wayfinding information challenges for libraries. Papers on library wayfinding often include some discussion of the lack of wayfinding research in libraries, but apparently there has been no comprehensive review of the LIS literature on wayfinding. Methods – This paper is a comprehensive review of library wayfinding literature, using the Library, Information Science & Technology Abstracts with Full Text (via EBSCOhost database to collect the dataset. Results – Findings indicate a small collection of library wayfinding research, primarily focused on academic libraries. Conclusion – Empirical research in this area is limited. Suggestions for future research on library wayfinding, including potential foci for that research, are presented.

Canadian Academic Library Support for International Faculty: Library Experience and Information Needs of Chinese Visiting Scholars at the University of Western Ontario

Directory of Open Access Journals (Sweden)

Shiyi Xie

2012-12-01

Full Text Available International faculty constitute a relatively small proportion of the library user community in Canadian post-secondary institutions, but they are underserved when compared to other user groups on campus, particularly international students. The author obtained first hand information about Chinese visiting scholars at the University of Western Ontario, and in this paper she presents conclusions from her experience regarding the visiting scholars' use of libraries as well as some recommendations for serving international faculty. The author suggests that academic libraries carefully consider international faculty when planning relevant services for diverse user groups. Providing necessary and satisfying library services for this group of patrons is an excellent opportunity to better serve academic communities and to demonstrate that academic libraries are an important partner in supporting their university's international initiatives.

The structural bioinformatics library: modeling in biomolecular science and beyond.

Science.gov (United States)

Cazals, Frédéric; Dreyfus, Tom

2017-04-01

Software in structural bioinformatics has mainly been application driven. To favor practitioners seeking off-the-shelf applications, but also developers seeking advanced building blocks to develop novel applications, we undertook the design of the Structural Bioinformatics Library ( SBL , http://sbl.inria.fr ), a generic C ++/python cross-platform software library targeting complex problems in structural bioinformatics. Its tenet is based on a modular design offering a rich and versatile framework allowing the development of novel applications requiring well specified complex operations, without compromising robustness and performances. The SBL involves four software components (1-4 thereafter). For end-users, the SBL provides ready to use, state-of-the-art (1) applications to handle molecular models defined by unions of balls, to deal with molecular flexibility, to model macro-molecular assemblies. These applications can also be combined to tackle integrated analysis problems. For developers, the SBL provides a broad C ++ toolbox with modular design, involving core (2) algorithms , (3) biophysical models and (4) modules , the latter being especially suited to develop novel applications. The SBL comes with a thorough documentation consisting of user and reference manuals, and a bugzilla platform to handle community feedback. The SBL is available from http://sbl.inria.fr. Frederic.Cazals@inria.fr. Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

From human monocytes to genome-wide binding sites--a protocol for small amounts of blood: monocyte isolation/ChIP-protocol/library amplification/genome wide computational data analysis.

Directory of Open Access Journals (Sweden)

Sebastian Weiterer

Full Text Available Chromatin immunoprecipitation in combination with a genome-wide analysis via high-throughput sequencing is the state of the art method to gain genome-wide representation of histone modification or transcription factor binding profiles. However, chromatin immunoprecipitation analysis in the context of human experimental samples is limited, especially in the case of blood cells. The typically extremely low yields of precipitated DNA are usually not compatible with library amplification for next generation sequencing. We developed a highly reproducible protocol to present a guideline from the first step of isolating monocytes from a blood sample to analyse the distribution of histone modifications in a genome-wide manner.The protocol describes the whole work flow from isolating monocytes from human blood samples followed by a high-sensitivity and small-scale chromatin immunoprecipitation assay with guidance for generating libraries compatible with next generation sequencing from small amounts of immunoprecipitated DNA.

Model, prediction, and experimental verification of composition and thickness in continuous spread thin film combinatorial libraries grown by pulsed laser deposition

International Nuclear Information System (INIS)

Bassim, N. D.; Schenck, P. K.; Otani, M.; Oguchi, H.

2007-01-01

Pulsed laser deposition was used to grow continuous spread thin film libraries of continuously varying composition as a function of position on a substrate. The thickness of each component that contributes to a library can be empirically modeled to a bimodal cosine power distribution. We deposited ternary continuous spread thin film libraries from Al 2 O 3 , HfO 2 , and Y 2 O 3 targets, at two different background pressures of O 2 : 1.3 and 13.3 Pa. Prior to library deposition, we deposited single component calibration films at both pressures in order to measure and fit the thickness distribution. Following the deposition and fitting of the single component films, we predict both the compositional coverage and the thickness of the libraries. Then, we map the thickness of the continuous spread libraries using spectroscopic reflectometry and measure the composition of the libraries as a function of position using mapping wavelength-dispersive spectrometry (WDS). We then compare the compositional coverage of the libraries and observe that compositional coverage is enhanced in the case of 13.3 Pa library. Our models demonstrate linear correlation coefficients of 0.98 for 1.3 Pa and 0.98 for 13.3 Pa with the WDS

Library 3.0 intelligent libraries and apomediation

CERN Document Server

Kwanya, Tom; Underwood, Peter

2015-01-01

The emerging generation of research and academic library users expect the delivery of user-centered information services. 'Apomediation' refers to the supporting role librarians can give users by stepping in when users need help. Library 3.0 explores the ongoing debates on the "point oh” phenomenon and its impact on service delivery in libraries. This title analyses Library 3.0 and its potential in creating intelligent libraries capable of meeting contemporary needs, and the growing role of librarians as apomediators. Library 3.0 is divided into four chapters. The first chapter introduces and places the topic in context. The second chapter considers "point oh” libraries. The third chapter covers library 3.0 librarianship, while the final chapter explores ways libraries can move towards '3.0'.

Customer service in libraries best practices

CERN Document Server

Harmon, Charles

2013-01-01

In this book, nine librarians from across the country describe their libraries' best practices in this key area. Their contributions range from all-encompassing customer service policies and models any library can both adapt and be proud of to micro-approaches that emphasize offering excellent user-focused technology planning, picture book arrangement with patrons in mind, Web 2.0 tools to connect users with the library, establishing good service delivery chains, and making your library fantastic for homeschoolers.

mr. A C++ library for the matching and running of the Standard Model parameters

International Nuclear Information System (INIS)

Kniehl, Bernd A.; Veretin, Oleg L.; Pikelner, Andrey F.; Joint Institute for Nuclear Research, Dubna

2016-01-01

We present the C++ program library mr that allows us to reliably calculate the values of the running parameters in the Standard Model at high energy scales. The initial conditions are obtained by relating the running parameters in the MS renormalization scheme to observables at lower energies with full two-loop precision. The evolution is then performed in accordance with the renormalization group equations with full three-loop precision. Pure QCD corrections to the matching and running are included through four loops. We also provide a Mathematica interface for this program library.

mr. A C++ library for the matching and running of the Standard Model parameters

Energy Technology Data Exchange (ETDEWEB)

Kniehl, Bernd A.; Veretin, Oleg L. [Hamburg Univ. (Germany). II. Inst. fuer Theoretische Physik; Pikelner, Andrey F. [Hamburg Univ. (Germany). II. Inst. fuer Theoretische Physik; Joint Institute for Nuclear Research, Dubna (Russian Federation). Bogoliubov Lab. of Theoretical Physics

2016-01-15

We present the C++ program library mr that allows us to reliably calculate the values of the running parameters in the Standard Model at high energy scales. The initial conditions are obtained by relating the running parameters in the MS renormalization scheme to observables at lower energies with full two-loop precision. The evolution is then performed in accordance with the renormalization group equations with full three-loop precision. Pure QCD corrections to the matching and running are included through four loops. We also provide a Mathematica interface for this program library.

Croatian library leaders’ views on (their library quality

Directory of Open Access Journals (Sweden)

Kornelija Petr Balog

2014-04-01

Full Text Available The purpose of this paper is to determine and describe the library culture in Croatian public libraries. Semi-structured interviews with 14 library directors (ten public and four academic were conducted. The tentative discussion topics were: definition of quality, responsibility for quality, satisfaction with library services, familiarization with user perspective of library and librarians, monitoring of user expectations and opinions. These interviews incorporate some of the findings of the project Evaluation of library and information services: public and academic libraries. The project investigates library culture in Croatian public and academic libraries and their preparedness for activities of performance measurement. The interviews reveal that library culture has changed positively in the past few years and that library leaders have positive attitude towards quality and evaluation activities. Library culture in Croatian libraries is a relatively new concept and as such was not actively developed and/or created. This article looks into the library culture of Croatian libraries, but at the same time investigates whether there is any trace of culture of assessment in them. Also, this article brings the latest update on views, opinions and atmosphere in Croatian public and academic libraries.

A Model for Designing Library Instruction for Distance Learning

Science.gov (United States)

Rand, Angela Doucet

2013-01-01

Providing library instruction in distance learning environments presents a unique set of challenges for instructional librarians. Innovations in computer-mediated communication and advances in cognitive science research provide the opportunity for designing library instruction that meets a variety of student information seeking needs. Using a…

Walking the talk: is your library a marketing oriented organisation?

OpenAIRE

Ewers, Barbara

2004-01-01

Libraries are increasingly vocal about the need to adopt strategic marketing management which is the process of creating and facilitating the exchange of products of value with others. However, the largest proportion of library and information science literature on marketing deals promotion and public relations which is only a small part of the marketing mix. There seems to have been a fragmented application of marketing principles in the management and operation of libraries because they hav...

Toward Continual Reform: Progress in Academic Libraries in China.

Science.gov (United States)

Ping, Ke

2002-01-01

Traces developments in China's academic libraries: managing human resources, restructuring library developments, revising and implementing new policies, evaluating services and operations, establishing library systems, building new structures, and exploring joint-use library models. Major focus was to improve services for library user. (Author/LRW)

E-book Reader Devices and Libraries

Directory of Open Access Journals (Sweden)

Pažur, I.

2011-03-01

Full Text Available Most library studies thematically related to electronic books don't consider readers of electronic books. Only in recent years librarians conduct studies in which they want to find out readers' opinions about the possibilities, advantages and disadvantages of reading using e-readers, as well as their possible application in the libraries.User studies of e-readers have shown that their opinion is generally positive, but great attachment to traditional books is still present, e-readers are still seen only as an additional tool for reading. Sony with its e-reader (the latest Reader model Daily and Reader Store online bookstore (http://ebookstore.sony.com/is the only one who cooperate with libraries and has made lending electronic books possible. Cooperation was launched in 2009th,and the New York Public Library was the first library that offered such a service.Cooperation between Sony and libraries, indicates clearly what the near future could be if other online booksellers / publishers begin to follow the model of lending e-books through the libraries over the network. However it is possible that a large online bookstores / publishers consider that the further price reduction of e-readers and electronic books will constantly increase their sales, and in that case lending e-books will be unnecessary.Are the libraries ready for this scenario?

Solid-Phase Synthesis of Small Molecule Libraries using Double Combinatorial Chemistry

DEFF Research Database (Denmark)

Nielsen, John; Jensen, Flemming R.

1997-01-01

The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can be demons...

External resources in Libraries: the practice of Fundraising in the State Public Library in Cáceres.

Directory of Open Access Journals (Sweden)

Margarita Pérez Pulido

2013-03-01

Full Text Available Fundraising is presented as a technique of marketing and communication for managing external resources in libraries. The convergence of the fundraising plan and conceptual planning model can prove the importance of fundraising as a planning tool. From the analysis of a case study, Caceres Public Library, are made some improvements to consolidate this practice as an essential element of the planning libraries.

Library of Congress Model, Anaglyph

Science.gov (United States)

2004-01-01

The Shuttle Radar Topography Mission (SRTM) has produced the first high-resolution, near-global elevation dataset of Earth. In recognition of this achievement, and as an illustration of the data, the United States Library of Congress now displays a 'solid terrain model' of Los Angeles and adjacent mountainous terrain. The model was created by carving a high-density foam block using computer-guided drills that referenced the SRTM dataset. The block was then covered with a Landsat satellite image using computer-guided paint guns that referenced both the Landsat image and the SRTM dataset. The view shown here mimics the actual model on display at the Library of Congress and was generated from the same satellite image and elevation data sets. Anaglyph glasses are required to see this view in three-dimensions. Anaglyph glasses cover the left eye with a red filter and cover the right eye with a blue filter. The model shows the Pacific Ocean and Santa Monica Mountains along the Malibu Coast (lower left), San Fernando Valley (left center), downtown Los Angeles (bottom center), San Gabriel and Pomona Valleys (lower right), San Gabriel Mountains (right center to far right), and part of the Mojave Desert (upper right). Colors are enhanced true color with added topographic shading, and elevation differences are exaggerated 1.5 times. The view is toward the north-northwest. The Los Angeles region was chosen for the Library of Congress model because it illustrates so many ways that topography affects the daily lives of people. The region consists of a coastal plain, inland valleys, mountains up to 3068 meters (10,064 feet), and a desert interior. Topography blocks the landward influence of marine airmasses here such that summer temperatures often differ by 40 degrees Fahrenheit (22 C) across this region at a given moment even at similar elevations. Temperatures also typically cool with rising elevation, and winter storms drop most of their moisture in the mountains, leaving

Research support services to small and medium enterprises by university libraries in Uganda: An entrepreneurial and innovation strategy

Directory of Open Access Journals (Sweden)

Robert S. Buwule

2017-10-01

Objectives: The objectives of this study were to: investigate how university libraries in Uganda are managing the universities’ research output; find out how the research output is disseminated to SMEs for their entrepreneurial activities, to understand how SMEs access and use R&I information for their entrepreneurial programmes; and propose feasible strategies of how best university libraries can re-engineer the dissemination of the research output for use by SMEs in their entrepreneurial endeavours. Method: The study used document analysis which is a qualitative data collection method. Empirical literature related to the research variables of the study was reviewed through systematic searching of manual and electronic documents on how university libraries treat their R&I information in relation to entrepreneurship. Results: The findings demonstrate that university libraries can re-engineer their R&I information services for SMEs through: repackaging R&I information in formats and languages easily accessible by SMEs; creating informal social networks for information sharing among SMEs; creation of R&I information library corners; University Library Consortia advocating for this concept; periodical announcements of new R&I information in the library through emails to SMEs; organising SME days in the library; creation of SME pages on the library website; conducting information literacy training sessions for SME entrepreneurs; and adding this concept in the library and information science curricular. Conclusion: This article discusses how university libraries, from a developing country context such as Uganda, can re-engineer research output for SMEs and use it to develop innovative solutions that can contribute positively towards SDGs and the social economic transformation of Africa at large.

La Administracion de las Bibliotecas Escolares (School Library Administration). IFLA Professional Reports, No. 29.

Science.gov (United States)

Galler, Anne M.; Coulter, Joan M.

This manual provides practical information on the planning, organization, and operation of school libraries. Some of the guidelines differentiate between small libraries with minimal collections and larger, better-equipped libraries with more resources. Introductory materials include definitions of terms used in this manual. Guidelines are then…

acme: The Amendable Coal-Fire Modeling Exercise. A C++ Class Library for the Numerical Simulation of Coal-Fires

Science.gov (United States)

Wuttke, Manfred W.

2017-04-01

At LIAG, we use numerical models to develop and enhance understanding of coupled transport processes and to predict the dynamics of the system under consideration. Topics include geothermal heat utilization, subrosion processes, and spontaneous underground coal fires. Although the details make it inconvenient if not impossible to apply a single code implementation to all systems, their investigations go along similar paths: They all depend on the solution of coupled transport equations. We thus saw a need for a modular code system with open access for the various communities to maximize the shared synergistic effects. To this purpose we develop the oops! ( open object-oriented parallel solutions) - toolkit, a C++ class library for the numerical solution of mathematical models of coupled thermal, hydraulic and chemical processes. This is used to develop problem-specific libraries like acme( amendable coal-fire modeling exercise), a class library for the numerical simulation of coal-fires and applications like kobra (Kohlebrand, german for coal-fire), a numerical simulation code for standard coal-fire models. Basic principle of the oops!-code system is the provision of data types for the description of space and time dependent data fields, description of terms of partial differential equations (pde), their discretisation and solving methods. Coupling of different processes, described by their particular pde is modeled by an automatic timescale-ordered operator-splitting technique. acme is a derived coal-fire specific application library, depending on oops!. If specific functionalities of general interest are implemented and have been tested they will be assimilated into the main oops!-library. Interfaces to external pre- and post-processing tools are easily implemented. Thus a construction kit which can be arbitrarily amended is formed. With the kobra-application constructed with acme we study the processes and propagation of shallow coal seam fires in particular in

Tomorrow's Research Library: Vigor or Rigor Mortis?

Science.gov (United States)

Hacken, Richard D.

1988-01-01

Compares, contrasts, and critiques predictions that have been made about the future of research libraries, focusing on the impact of technology on the library's role and users' needs. The discussion includes models for the adaptation of new technologies that may assist in library planning and change. (38 references) (CLB)

The BCRA’s Small Economic Model

OpenAIRE

Pedro Elosegui; Guillermo Escudé; Lorena Garegnani; Juan Martín Sotes Paladino

2007-01-01

The use of macroeconomic forecasting models is a common practice in central banks for monetary policy design, for the analysis of the current economic developments and for medium and long term forecasts. Among those models, the small-scale macroeconomic models stand out. Though relatively simple, they are structured and take into account the transmission mechanisms that relate the main variables of interest: the interest rate, the exchange rate, GDP and inflation. The Small Economic Model (ME...

ZZ-CENPL, Chinese Evaluated Nuclear Parameter Library. ZZ CENPL-DLS, Discrete Level Schemes and Gamma Branching Ratios Library; ZZ CENPL-FBP, Fission Barrier Parameter Library; ZZ CENPL-GDRP, Giant Dipole Resonance Parameter Library; ZZ CENPL-NLD, Nuclear Level Density Parameter Library; ZZ CENPL-MCC, Nuclear Ground State Atomic Masses Library; ZZ CENPL-OMP, Optical Model Parameter Library

International Nuclear Information System (INIS)

Su Zongdi

1995-01-01

Description of program or function: CENPL - GDRP (Giant Dipole Resonance Parameters for Gamma-Ray): - Format: special format described in documentation; - Nuclides: V, Mn, Co, Ni, Cu, Zn, Ga, Ge, As, Se, Rb, Sr, Y, Zr, Nb, Mo, Rh, Pd, Ag, Cd, In, Sn, Sb, Te, I, Cs, Ba, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Ho, Er, Lu, Ta, W, Re, Os, Ir, Pt, Au, Hg, Pb, Bi, Th, U, Np, Pu. - Origin: Experimental values offered by S.S. Dietrich and B.L. Berman. CENPL - FBP (Fission Barrier Parameter Sub-Library): - Format: special format described in documentation; - Nuclides: (1) 51 nuclei region from Th-230 to Cf-255, (2) 46 nuclei region from Th-229 to Cf-253, (3) 24 nuclei region from Pa-232 to Cf-253; - Origin: (1) Lynn, (2) Analysis of experimental data by Back et al., (3) Ohsawa. CENPL - DLS (Discrete level scheme and branch ratio of gamma decay: - Format: Special format described in documentation; - Origin: ENSDF - BNL. CENPL - NLD (Nuclear Level Density): - Format: Special format described in documentation; - Origin: Huang Zhongfu et al. CENPL - OMP (Optical model parameter sub-library): - Format: special format described in documentation ; - Origin: CENDL, ENDF/B-VI, JENDL-3. CENPL - MC (I) and (II) (Atomic masses and characteristic constants for nuclear ground states) : - Format: Brief table format; - Nuclides: 4760 nuclides ranging from Z=0 A=1 to Z=122 A=318. - Origin: Experimental data and systematic results evaluated by Wapstra, theoretical results calculated by Moller, ENSDF - BNL and Nuclear Wallet Cards. CENPL contains the following six sub-libraries: 1. Atomic Masses and Characteristic Constants for nuclear ground states (MCC). This data consists of calculated and in most cases also measured mass excesses, atomic masses, total binding energies, spins, parities, and half-lives of nuclear ground states, abundances, etc. for 4800 nuclides. 2. Discrete Level Schemes and branching ratios of gamma decay (DLS). The data on nuclear discrete levels are based on the Evaluated

Construction of High-Quality Camel Immune Antibody Libraries.

Science.gov (United States)

Romão, Ema; Poignavent, Vianney; Vincke, Cécile; Ritzenthaler, Christophe; Muyldermans, Serge; Monsion, Baptiste

2018-01-01

Single-domain antibodies libraries of heavy-chain only immunoglobulins from camelids or shark are enriched for high-affinity antigen-specific binders by a short in vivo immunization. Thus, potent binders are readily retrieved from relatively small-sized libraries of 10 7 -10 8 individual transformants, mostly after phage display and panning on a purified target. However, the remaining drawback of this strategy arises from the need to generate a dedicated library, for nearly every envisaged target. Therefore, all the procedures that shorten and facilitate the construction of an immune library of best possible quality are definitely a step forward. In this chapter, we provide the protocol to generate a high-quality immune VHH library using the Golden Gate Cloning strategy employing an adapted phage display vector where a lethal ccdB gene has to be substituted by the VHH gene. With this procedure, the construction of the library can be shortened to less than a week starting from bleeding the animal. Our libraries exceed 10 8 individual transformants and close to 100% of the clones harbor a phage display vector having an insert with the length of a VHH gene. These libraries are also more economic to make than previous standard approaches using classical restriction enzymes and ligations. The quality of the Nanobodies that are retrieved from immune libraries obtained by Golden Gate Cloning is identical to those from immune libraries made according to the classical procedure.

A novel Direct Small World network model

Directory of Open Access Journals (Sweden)

LIN Tao

2016-10-01

Full Text Available There is a certain degree of redundancy and low efficiency of existing computer networks.This paper presents a novel Direct Small World network model in order to optimize networks.In this model,several nodes construct a regular network.Then,randomly choose and replot some nodes to generate Direct Small World network iteratively.There is no change in average distance and clustering coefficient.However,the network performance,such as hops,is improved.The experiments prove that compared to traditional small world network,the degree,average of degree centrality and average of closeness centrality are lower in Direct Small World network.This illustrates that the nodes in Direct Small World networks are closer than Watts-Strogatz small world network model.The Direct Small World can be used not only in the communication of the community information,but also in the research of epidemics.

Digital Libraries from Concept to Practice

CERN Document Server

Banciu, D

2007-01-01

The paper represents the result of research in the field of digital libraries functionalities in the context of new Grid infrastructure support. It is defined a new vector of knowledge society, informational vector - content vector. It presents a Grid European project which includes Romanian partners, and it defines on this base a digital library model which can be applied for the libraries in Romania.

Data Content Protection for Virtual Libraries Heritage

Directory of Open Access Journals (Sweden)

Mihai DOINEA

2016-01-01

Full Text Available This paper presents aspects of digital content protection in virtual library systems. The legislation aspects are presented to better emphasize the need of new security mechanisms. Integrated library systems architecture is presented with focus on their main purpose, manipulating and rendering digital content to end-users. The cultural heritage stored in such systems is an important asset that needs to be protected against malicious manipulation. The characteristics of a smart virtual library, supported by an integrated library system, are analyzed and a security model is proposed for implementation, based on its particularities. The model aims to be an interface between the interactions of anonymous users with the Online Public Access Catalog of a virtual library that assures the protection of digital content. Conclusions are drawn to better support the idea of cultural persistence by the use of Information Systems.

Cross-section libraries and kerma factors

International Nuclear Information System (INIS)

Little, R.C.; MacFarlane, R.E.; Seamon, R.E.

1991-01-01

A large amount of data is required in order to accurately simulate various aspects of Cold Neutron Sources using radiation transport codes such as MCNP and TWODANT. In particular, the following types of data are needed: couple neutron/photon transport libraries, neutron thermal S(α,β) data, response function data (including energy deposition), and proton interaction data. This paper concentrates on the coupled neutron/photon transport libraries and energy deposition. Data libraries available to radiation transport codes are obtained as a result of efforts in many areas, including differential and integral measurements, theoretical model codes, data evaluations, data processing, and data testing. A wide variety of data libraries are available to users of radiation transport codes, including pointwise and multigroup libraries. At Los Alamos, the authors generally recommend the use of data libraries derived from ENDF/B-V. It is often important to know how much energy is deposited in various regions of a device. This problem is typically modeled in radiation transport codes by folding the calculated fluences with an energy-dependent 'heating number'. The heating number represents the average energy deposited locally per collision. Calculation of these heating numbers from evaluated data libraries is fraught with difficulty. Many past difficulties related to energy deposition should be resolved by the release of ENDF/B-VI

Libraries for users services in academic libraries

CERN Document Server

Alvite, Luisa

2010-01-01

This book reviews the quality and evolution of academic library services. It revises service trends offered by academic libraries and the challenge of enhancing traditional ones such as: catalogues, repositories and digital collections, learning resources centres, virtual reference services, information literacy and 2.0 tools.studies the role of the university library in the new educational environment of higher educationrethinks libraries in academic contextredefines roles for academic libraries

The Medical Library Association Benchmarking Network: results.

Science.gov (United States)

Dudden, Rosalind Farnam; Corcoran, Kate; Kaplan, Janice; Magouirk, Jeff; Rand, Debra C; Smith, Bernie Todd

2006-04-01

This article presents some limited results from the Medical Library Association (MLA) Benchmarking Network survey conducted in 2002. Other uses of the data are also presented. After several years of development and testing, a Web-based survey opened for data input in December 2001. Three hundred eighty-five MLA members entered data on the size of their institutions and the activities of their libraries. The data from 344 hospital libraries were edited and selected for reporting in aggregate tables and on an interactive site in the Members-Only area of MLANET. The data represent a 16% to 23% return rate and have a 95% confidence level. Specific questions can be answered using the reports. The data can be used to review internal processes, perform outcomes benchmarking, retest a hypothesis, refute a previous survey findings, or develop library standards. The data can be used to compare to current surveys or look for trends by comparing the data to past surveys. The impact of this project on MLA will reach into areas of research and advocacy. The data will be useful in the everyday working of small health sciences libraries as well as provide concrete data on the current practices of health sciences libraries.

The Medical Library Association Benchmarking Network: results*

Science.gov (United States)

Dudden, Rosalind Farnam; Corcoran, Kate; Kaplan, Janice; Magouirk, Jeff; Rand, Debra C.; Smith, Bernie Todd

2006-01-01

Objective: This article presents some limited results from the Medical Library Association (MLA) Benchmarking Network survey conducted in 2002. Other uses of the data are also presented. Methods: After several years of development and testing, a Web-based survey opened for data input in December 2001. Three hundred eighty-five MLA members entered data on the size of their institutions and the activities of their libraries. The data from 344 hospital libraries were edited and selected for reporting in aggregate tables and on an interactive site in the Members-Only area of MLANET. The data represent a 16% to 23% return rate and have a 95% confidence level. Results: Specific questions can be answered using the reports. The data can be used to review internal processes, perform outcomes benchmarking, retest a hypothesis, refute a previous survey findings, or develop library standards. The data can be used to compare to current surveys or look for trends by comparing the data to past surveys. Conclusions: The impact of this project on MLA will reach into areas of research and advocacy. The data will be useful in the everyday working of small health sciences libraries as well as provide concrete data on the current practices of health sciences libraries. PMID:16636703

Making the Invisible Visible: Personas and Mental Models of Distance Education Library Users

Science.gov (United States)

Lewis, Cynthia; Contrino, Jacline

2016-01-01

Gaps between users' and designers' mental models of digital libraries often result in adverse user experiences. This article details an exploratory user research study at a large, predominantly online university serving non-traditional distance education students with the goal of understanding these gaps. Using qualitative data, librarians created…

Conceptualising 'knowledge management' in the context of library and information science using the core/periphery model

Directory of Open Access Journals (Sweden)

O.B. Onyancha

2009-04-01

Full Text Available This study took cognisance of the fact that the term 'knowledge management' lacks a universally accepted definition, and consequently sought to describe the term using the most common co-occurring terms in knowledge management (KM literature as indexed in the Library, Information Science and Technology Abstracts (LISTA database. Using a variety of approaches and analytic techniques (e.g. core/periphery analysis and co-occurrence of words as subject terms, data were analysed using the core/periphery model and social networks through UCINET for Windows, TI, textSTAT and Bibexcel computer-aided software. The study identified the following as the compound terms with which KM co-occurs most frequently: information resources management, information science, information technology, information services, information retrieval, library science, management information systems and libraries. The core single subject terms with which KM can be defined include resources, technology, libraries, systems, services, retrieval, storage, data and computers. The article concludes by offering the library and information science (LIS professionals' general perception of KM based on their use of terms, through which KM can be defined within the context of LIS.

Setting up and Running a School Library. Information Collection and Exchange Publication No. ED204

Science.gov (United States)

Baird, Nicola

2012-01-01

This book explains how teachers can set up and run a successful school library. In it you will find advice and information on how to: (1) set up a small library and build bookshelves; (2) select books for your library; (3) make a written record of your school's books, pamphlets and other library stock such as newspapers, magazines, audio tapes and…

Tandem Mannich/Diels–Alder reactions for the synthesis of indole compound libraries

DEFF Research Database (Denmark)

Wu, Peng; Petersen, Michael Åxman; Petersen, Rico

2016-01-01

A tandem Mannich/Diels–Alder sequence for the synthesis of small-molecule libraries with an indolyl-octahydro-3a,6-epoxy-isoindole core structure is demonstrated in this study. Representative diversification examples based on this scaffold were performed, and a library is being produced within...

Media Magic: Automating a K-12 Library Program in a Rural District.

Science.gov (United States)

Adams, Helen

1994-01-01

Describes the automation process in a library resources center in a small rural school district. Topics discussed include long-range planning; retrospective conversion for an online catalog; library automation software vendors; finances; training; time savings; CD-ROM products; telecomputing; computer literacy skills; professional development…

Library Literacy Programs for English Language Learners. ERIC Digest.

Science.gov (United States)

McMurrer, Eileen; Terrill, Lynda

This digest summarizes the history of public libraries and library literacy programs; describes current delivery models; and discusses initiatives in library literacy, profiling one successful public library program that serves adult English language learners and their families. (Adjunct ERIC Clearinghouse for ESL Literacy Education) (Author/VWL)

Component, Context and Manufacturing Model Library (C2M2L)

Science.gov (United States)

2013-03-01

Penn State team were stored in a relational database for easy access, storage and maintainability. The relational database consisted of a PostGres ...file into a format that can be imported into the PostGres database. This same custom application was used to generate Microsoft Excel templates...Press Break Forming Equipment 4.14 Manufacturing Model Library Database Structure The data storage mechanism for the ARL PSU MML was a PostGres database

An open-source library for the numerical modeling of mass-transfer in solid oxide fuel cells

Science.gov (United States)

Novaresio, Valerio; García-Camprubí, María; Izquierdo, Salvador; Asinari, Pietro; Fueyo, Norberto

2012-01-01

The generation of direct current electricity using solid oxide fuel cells (SOFCs) involves several interplaying transport phenomena. Their simulation is crucial for the design and optimization of reliable and competitive equipment, and for the eventual market deployment of this technology. An open-source library for the computational modeling of mass-transport phenomena in SOFCs is presented in this article. It includes several multicomponent mass-transport models ( i.e. Fickian, Stefan-Maxwell and Dusty Gas Model), which can be applied both within porous media and in porosity-free domains, and several diffusivity models for gases. The library has been developed for its use with OpenFOAM ®, a widespread open-source code for fluid and continuum mechanics. The library can be used to model any fluid flow configuration involving multicomponent transport phenomena and it is validated in this paper against the analytical solution of one-dimensional test cases. In addition, it is applied for the simulation of a real SOFC and further validated using experimental data. Program summaryProgram title: multiSpeciesTransportModels Catalogue identifier: AEKB_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEKB_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU General Public License No. of lines in distributed program, including test data, etc.: 18 140 No. of bytes in distributed program, including test data, etc.: 64 285 Distribution format: tar.gz Programming language:: C++ Computer: Any x86 (the instructions reported in the paper consider only the 64 bit case for the sake of simplicity) Operating system: Generic Linux (the instructions reported in the paper consider only the open-source Ubuntu distribution for the sake of simplicity) Classification: 12 External routines: OpenFOAM® (version 1.6-ext) ( http://www.extend-project.de) Nature of problem: This software provides a library of models for

Training library patrons the ADDIE way

CERN Document Server

Wegener, Debby

2006-01-01

This book takes an informal and in-depth look at the five steps of the ADDIE model - Analysis, Design, Development, Implementation and Evaluation - as used in library training programmes. With hints and tips and practical advice from other trainers, the aims of the book are to (1) make the training of library patrons a simple task and (2) to show library staff that training can be rewarding and extremely satisfying. Anyone who has had to design a library training programme will know that it can be quite a daunting task without guidelines, but when it comes to the various learning theories and

The ENDF/B-VI photon interaction library

International Nuclear Information System (INIS)

Cullen, D.E.; Perkins, S.T.; Plechaty, E.F.

1992-02-01

The ENDF/B-VI photon interaction library includes data to describe the interaction of photons with the elements Z = 1 to 100 over the energy range 10 eV to 100 MeV. This library has been designed to meet the traditional needs of users to model the interaction and transport of primary photons. However, this library contains additional information which used in a combination with our other data libraries can be used to perform much more detailed calculations, e.g., emission of secondary fluorescence photons. This paper describes both traditional and more detailed uses of this library

Effect of updated WIMSD libraries on neutron energy spectrum at irradiation site of Pakistan Research Reactor-1 using 3D modeling

International Nuclear Information System (INIS)

Ahmad, Siraj-ul-Islam; Ahmad, Nasir

2005-01-01

International Atomic Energy Agency (IAEA) has recently released new WIMSD libraries based on current cross-section evaluations. Using these libraries the effect of different evaluated data sets on effective multiplication factor and neutron energy spectrum was studied with the help of 3D reactor simulation code CITATION. Simulation methodology adopted in this work was validated by analyzing IAEA 10 MW benchmark reactor. The k eff values obtained using all newly released libraries are within 0.45% to the experimental value, while the old library released in 1981 resulted in calculated value 1.05% larger than experimental. The flux spectrum obtained for standard fuel element using 3D modeling is smaller in fast energy range and higher in thermal energy range than is calculated using the 1D model for the standard cell. In the flux trap, differences of about -4% to 13% were found in thermal flux using the newly released libraries as compared to that obtained using 1981 WIMSD library. The major differences in the flux spectra between newly available libraries and the 1981 WIMSD library in thermal energy range are due to the differences in cross-sections of hydrogen bound-in-water. The use of only newly available cross-sections of hydrogen bound-in-water with 1981 WIMSD library resulted in significant improvement in value of k eff as well as in the flux spectrum. Moreover the differences among new libraries in the thermal energy range are also due to these cross-sections. Difference in fission spectra from different libraries is responsible for differences of flux spectra in the fast energy range. These differences in flux are reduced significantly in the fast energy range by only replacement of fission spectra

A Feminist Paradigm for Library and Information Science.

Science.gov (United States)

Hannigan, Jane Anne; Crew, Hilary

1993-01-01

Discussion of feminist scholarship and feminist thinking focuses on feminism in librarianship. Topics addressed include research methodologies; implications for library and information science; a feminist model, including constructed knowledge; standpoint theory; benefits of feminist scholarship; and a library model. (Contains 14 references.) (LRW)

A Model Assessing Relevant Factors in Building Minority Library Service.

Science.gov (United States)

Bonin, Kenneth Roy

1983-01-01

Presents research design applicable to definition of minority library service needs for any minority language group in Canada, focusing on French-speaking population outside Quebec. Profiles of the target group's population, culture, needs, and library services are highlighted. Five sources are given. (EJS)

Introduction to the library and information professions

CERN Document Server

Greer, Roger; Fowler, Susan

2013-01-01

In this rapidly changing, knowledge-based society, library and information professionals require a broad understanding of the profession. Introduction to the Library and Information Professions, Second Edition presents a toolbox of models that enable this essential understanding for undergraduate and graduate students in library and information science programs as well as practicing professionals seeking continuing education. The materials in this second edition reflect the latest trends in the library and information profession, including services and issues that stem from new advances in te

Progress on Chinese evaluated nuclear parameters library (CENPL). Pt. 3

International Nuclear Information System (INIS)

Su Zongdi; Ge Zhigang; Zhou Chunmei

1994-01-01

The progress on Chinese evaluated nuclear parameters library (CENPL) is introduced. The setting up work of each sub-library of CENPL has got some new progresses at the past period. These sub-libraries are atomic mass and characteristic constant for nuclear ground state sub-library, discrete level scheme and batch ratio of γ decay sub-library, level density parameter sub-library, giant dipole resonance parameter for γ-ray strength function sub-library and optical model parameter sub-library

iTesla Power Systems Library (iPSL): A Modelica library for phasor time-domain simulations

Science.gov (United States)

Vanfretti, L.; Rabuzin, T.; Baudette, M.; Murad, M.

The iTesla Power Systems Library (iPSL) is a Modelica package providing a set of power system components for phasor time-domain modeling and simulation. The Modelica language provides a systematic approach to develop models using a formal mathematical description, that uniquely specifies the physical behavior of a component or the entire system. Furthermore, the standardized specification of the Modelica language (Modelica Association [1]) enables unambiguous model exchange by allowing any Modelica-compliant tool to utilize the models for simulation and their analyses without the need of a specific model transformation tool. As the Modelica language is being developed with open specifications, any tool that implements these requirements can be utilized. This gives users the freedom of choosing an Integrated Development Environment (IDE) of their choice. Furthermore, any integration solver can be implemented within a Modelica tool to simulate Modelica models. Additionally, Modelica is an object-oriented language, enabling code factorization and model re-use to improve the readability of a library by structuring it with object-oriented hierarchy. The developed library is released under an open source license to enable a wider distribution and let the user customize it to their specific needs. This paper describes the iPSL and provides illustrative application examples.

Welcome to the National Wetlands Research Center Library: Not Just Another Library-A Special Library

Science.gov (United States)

Broussard, Linda

2007-01-01

Libraries are grouped into four major types: public, school, academic, and special. The U.S. Geological Survey's (USGS) National Wetlands Research Center (NWRC) library is classified as a special library because it is sponsored by the Federal government, and the collections focus on a specific subject. The NWRC library is the only USGS library dedicated to wetland science. Library personnel offer expert research services to meet the informational needs of NWRC scientists, managers, and support personnel. The NWRC library participates in international cataloging and resource sharing, which allows libraries from throughout the world to borrow from its collections. This sharing facilitates the research of other governmental agencies, universities, and those interested in the study of wetlands.

Designing Syntax Embeddings and Assimilations for Language Libraries

NARCIS (Netherlands)

Bravenboer, M.; Visser, E.

2009-01-01

Preprint of paper published in: Models in Software Engineering, Lecture Notes in Computer Science 5002, 2008; doi:10.1007/978-3-540-69073-3_5 Language libraries extend regular libraries with domain-specific notation. More precisely, a language library is a combination of a domain-specific language

Use of models in small mammal population studies

International Nuclear Information System (INIS)

Conley, W.; Nichols, J.D.

1978-01-01

The role of models as contributors to the understanding of natural populations of small mammals is reviewed. A philosophy of model use and projections for future work are also included. Categories of biological phenomena reviewed include models on population dynamics (demographic variables and population regulation, dispersal, sex-ratios, predation, population cycles), population responses to environmental conditions, genetics of small mammal populations, competitive interactions, ecosystems and small mammal functions, and control and management of small mammal populations

Assessing Library Automation and Virtual Library Development in Four Academic Libraries in Oyo, Oyo State, Nigeria

Science.gov (United States)

Gbadamosi, Belau Olatunde

2011-01-01

The paper examines the level of library automation and virtual library development in four academic libraries. A validated questionnaire was used to capture the responses from academic librarians of the libraries under study. The paper discovers that none of the four academic libraries is fully automated. The libraries make use of librarians with…

Hijazi Architectural Object Library (haol)

Science.gov (United States)

Baik, A.; Boehm, J.

2017-02-01

As with many historical buildings around the world, building façades are of special interest; moreover, the details of such windows, stonework, and ornaments give each historic building its individual character. Each object of these buildings must be classified in an architectural object library. Recently, a number of researches have been focusing on this topic in Europe and Canada. From this standpoint, the Hijazi Architectural Objects Library (HAOL) has reproduced Hijazi elements as 3D computer models, which are modelled using a Revit Family (RFA). The HAOL will be dependent on the image survey and point cloud data. The Hijazi Object such as Roshan and Mashrabiyah, become as vocabulary of many Islamic cities in the Hijazi region such as Jeddah in Saudi Arabia, and even for a number of Islamic historic cities such as Istanbul and Cairo. These architectural vocabularies are the main cause of the beauty of these heritage. However, there is a big gap in both the Islamic architectural library and the Hijazi architectural library to provide these unique elements. Besides, both Islamic and Hijazi architecture contains a huge amount of information which has not yet been digitally classified according to period and styles. Due to this issue, this paper will be focusing on developing of Heritage BIM (HBIM) standards and the HAOL library to reduce the cost and the delivering time for heritage and new projects that involve in Hijazi architectural styles. Through this paper, the fundamentals of Hijazi architecture informatics will be provided via developing framework for HBIM models and standards. This framework will provide schema and critical information, for example, classifying the different shapes, models, and forms of structure, construction, and ornamentation of Hijazi architecture in order to digitalize parametric building identity.

Library of Advanced Materials for Engineering (LAME) 4.44.

Energy Technology Data Exchange (ETDEWEB)

Plews, Julia A.; Crane, Nathan K; de Frias, Gabriel Jose; Le, San; Littlewood, David John; Merewether, Mark Thomas; Mosby, Matthew David; Pierson, Kendall H.; Porter, Vicki L.; Shelton, Timothy; Thomas, Jesse David; Tupek, Michael R.; Veilleux, Michael; Xavier, Patrick G.

2017-04-01

Accurate and efficient constitutive modeling remains a cornerstone issues for solid mechanics analysis. Over the years, the LAME advanced material model library has grown to address this challenge by implementing models capable of describing material systems spanning soft polymers to s ti ff ceramics including both isotropic and anisotropic responses. Inelastic behaviors including (visco) plasticity, damage, and fracture have all incorporated for use in various analyses. This multitude of options and flexibility, however, comes at the cost of many capabilities, features, and responses and the ensuing complexity in the resulting implementation. Therefore, to enhance confidence and enable the utilization of the LAME library in application, this effort seeks to document and verify the various models in the LAME library. Specifically, the broader strategy, organization, and interface of the library itself is first presented. The physical theory, numerical implementation, and user guide for a large set of models is then discussed. Importantly, a number of verification tests are performed with each model to not only have confidence in the model itself but also highlight some important response characteristics and features that may be of interest to end-users. Finally, in looking ahead to the future, approaches to add material models to this library and further expand the capabilities are presented.

Library of Advanced Materials for Engineering (LAME) 4.48.

Energy Technology Data Exchange (ETDEWEB)

Plews, Julia A.; Crane, Nathan K; de Frias, Gabriel Jose; Le, San; Littlewood, David John; Merewether, Mark Thomas; Mosby, Matthew David; Pierson, Kendall H.; Porter, Vicki L.; Shelton, Timothy; Thomas, Jesse David; Tupek, Michael R.; Veilleux, Michael; Xavier, Patrick G.

2018-03-01

Accurate and efficient constitutive modeling remains a cornerstone issues for solid mechanics analysis. Over the years, the LAME advanced material model library has grown to address this challenge by implement- ing models capable of describing material systems spanning soft polymers to stiff ceramics including both isotropic and anisotropic responses. Inelastic behaviors including (visco)plasticity, damage, and fracture have all incorporated for use in various analyses. This multitude of options and flexibility, however, comes at the cost of many capabilities, features, and responses and the ensuing complexity in the resulting imple- mentation. Therefore, to enhance confidence and enable the utilization of the LAME library in application, this effort seeks to document and verify the various models in the LAME library. Specifically, the broader strategy, organization, and interface of the library itself is first presented. The physical theory, numerical implementation, and user guide for a large set of models is then discussed. Importantly, a number of verifi- cation tests are performed with each model to not only have confidence in the model itself but also highlight some important response characteristics and features that may be of interest to end-users. Finally, in looking ahead to the future, approaches to add material models to this library and further expand the capabilities are presented.

Library thermohydraulic components for training simulators

International Nuclear Information System (INIS)

Castelao Caruana, M. J.; Di Benedetto, A.; Pierini, J.P.

2013-01-01

The thermohydraulic components Library was modeled in MatLab/Simulink®. This library owns Pipe type components (pump, control valve and / or heaters), storage tanks (Open, Closed and Equilibrium Water Vapor-Air) and Heat Exchangers (Co-Current, Counter-Current and U-tubes). Each component can be attached to other components through the component library Header, in order to create a more complex thermal-hydraulic system which in turn can interact with other thermal-hydraulic systems. (author)

Enterprise Reference Library

Science.gov (United States)

Bickham, Grandin; Saile, Lynn; Havelka, Jacque; Fitts, Mary

2011-01-01

Introduction: Johnson Space Center (JSC) offers two extensive libraries that contain journals, research literature and electronic resources. Searching capabilities are available to those individuals residing onsite or through a librarian s search. Many individuals have rich collections of references, but no mechanisms to share reference libraries across researchers, projects, or directorates exist. Likewise, information regarding which references are provided to which individuals is not available, resulting in duplicate requests, redundant labor costs and associated copying fees. In addition, this tends to limit collaboration between colleagues and promotes the establishment of individual, unshared silos of information The Integrated Medical Model (IMM) team has utilized a centralized reference management tool during the development, test, and operational phases of this project. The Enterprise Reference Library project expands the capabilities developed for IMM to address the above issues and enhance collaboration across JSC. Method: After significant market analysis for a multi-user reference management tool, no available commercial tool was found to meet this need, so a software program was built around a commercial tool, Reference Manager 12 by The Thomson Corporation. A use case approach guided the requirements development phase. The premise of the design is that individuals use their own reference management software and export to SharePoint when their library is incorporated into the Enterprise Reference Library. This results in a searchable user-specific library application. An accompanying share folder will warehouse the electronic full-text articles, which allows the global user community to access full -text articles. Discussion: An enterprise reference library solution can provide a multidisciplinary collection of full text articles. This approach improves efficiency in obtaining and storing reference material while greatly reducing labor, purchasing and

Disaster Response and Planning for Libraries.

Science.gov (United States)

Kahn, Miriam B.

Providing a customized disaster response plan to assist libraries in quick recovery, this resource also outlines step to minimize damage and protect materials before trouble strikes. The first section of the book, "Response," contains information how to handle small jobs in-house and suggestions for working with contractors--with an…

MARKETING LIBRARY SERVICES IN ACADEMIC LIBRARIES: A ...

African Journals Online (AJOL)

MARKETING LIBRARY SERVICES IN ACADEMIC LIBRARIES: A TOOL FOR SURVIVAL IN THE ... This article discusses the concept of marketing library and information services as an ... EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT

Libraries and Accessibility: Istanbul Public Libraries Case

Directory of Open Access Journals (Sweden)

Gül Yücel

2016-12-01

Full Text Available In the study; the assessment of accessibility has been conducted in Istanbul public libraries within the scope of public area. Public libraries commonly serve with its user of more than 20 million in total, spread to the general of Turkey, having more than one thousand branches in the centrums and having more than one million registered members. The building principles and standards covering the subjects such as the selection of place, historical and architectural specification of the region, distance to the centre of population and design in a way that the disabled people could benefit from the library services fully have been determined with regulations in the construction of new libraries. There are works for the existent libraries such as access for the disabled, fire safety precautions etc. within the scope of the related standards. Easy access by everyone is prioritized in the public libraries having a significant role in life-long learning. The purpose of the study is to develop solution suggestions for the accessibility problems in the public libraries. The study based on the eye inspection and assessments carried out within the scope of accessibility in the public libraries subsidiary to Istanbul Culture and Tourism Provincial Directorate Library and Publications Department within the provincial borders of Istanbul. The arrangements such as reading halls, study areas, book shelves etc. have been examined within the frame of accessible building standards. Building entrances, ramps and staircases, horizontal and vertical circulation of building etc. have been taken into consideration within the scope of accessible building standards. The subjects such as the reading and studying areas and book shelf arrangements for the library have been assessed within the scope of specific buildings. There are a total of 34 public libraries subsidiary to Istanbul Culture and Tourism Provincial Directorate on condition that 20 ea. of them are in the

Connections for Small Vertex Models

Indian Academy of Sciences (India)

This paper is a first attempt at calssifying connections on small vertex models i.e., commuting squares of the form displayed in (1.2) below. ... obtain necessary conditions for two such `model connections' in (2, ) to be ... Current Issue : Vol.

The Chandra X-ray Observatory PSF Library

Science.gov (United States)

Karovska, M.; Beikman, S. J.; Elvis, M. S.; Flanagan, J. M.; Gaetz, T.; Glotfelty, K. J.; Jerius, D.; McDowell, J. C.; Rots, A. H.

Pre-flight and on-orbit calibration of the Chandra X-Ray Observatory provided a unique base for developing detailed models of the optics and detectors. Using these models we have produced a set of simulations of the Chandra point spread function (PSF) which is available to the users via PSF library files. We describe here how the PSF models are generated and the design and content of the Chandra PSF library files.

Electrical Components Library for HAWC2

DEFF Research Database (Denmark)

Cutululis, Nicolaos A.; Larsen, Torben J.; Sørensen, Poul

and Aalborg University. In this project, the focus is on the development of a simulation platform for wind turbine systems using different simulation tools. This report presents the electric component library developed for use in the aeroelastic code HAWC2. The developed library includes both steady state...... was developed. The model includes the dynamics of the rotor fluxes. The model is suitable for a more detailed investigation of the mechanical - electrical interaction, both under normal and fault operation. For the variable speed wind turbine, a steadystate model, typically used in aeroelastic design...

Production of the next-generation library virtual tour

Science.gov (United States)

Duncan, James M.; Roth, Linda K.

2001-01-01

While many libraries offer overviews of their services through their Websites, only a small number of health sciences libraries provide Web-based virtual tours. These tours typically feature photographs of major service areas along with textual descriptions. This article describes the process for planning, producing, and implementing a next-generation virtual tour in which a variety of media elements are integrated: photographic images, 360-degree “virtual reality” views, textual descriptions, and contextual floor plans. Hardware and software tools used in the project are detailed, along with a production timeline and budget, tips for streamlining the process, and techniques for improving production. This paper is intended as a starting guide for other libraries considering an investment in such a project. PMID:11837254

Public libraries in the library regions in the year 2009

Directory of Open Access Journals (Sweden)

Milena Bon

2011-01-01

Full Text Available Purpose: Regional public libraries were initiated in 2003 to connect professional activities of libraries within regional networks and to ensure coordinated library development in a region in cooperation with the Library System Development Centre at the National and University Library performing a coordinating role. The article analyses the performance of public libraries and their integration in regional library networks in order to find out the level of development of conditions of performance of public libraries.Methodology/approach: Statistical data for the year 2009 were the basis for the overview of library activities of ten library regions with regard to applicable legislation and library standards. The level of regional library activities is compared to the socio-economic situation of statistical regions thus representing a new approach to the presentation of Slovenian’s public libraries’ development.Results: Absolute values indicate better development of nine libraries in the central Slovenia region while relative values offer a totally different picture. Four libraries in the region of Nova Gorica prove the highest level of development.Research limitation: Research is limited to the year 2009 and basic statistical analysis.Originality/practical implications: Findings of the analysis are useful for public libraries to plan their development strategy within a region and for financial bodies to provide for adequate financing for library activities in a specific region. The basic condition for successful public library performance is the even and harmonized development of conditions of performance as recommended by library standards.

Unified accelerator libraries

International Nuclear Information System (INIS)

Malitsky, Nikolay; Talman, Richard

1997-01-01

A 'Universal Accelerator Libraries' (UAL) environment is described. Its purpose is to facilitate program modularity and inter-program and inter-process communication among heterogeneous programs. The goal ultimately is to facilitate model-based control of accelerators

Design of the Modelica Library VehProLib with Non-ideal Gas Models in Engines

OpenAIRE

Andersson, Conny

2015-01-01

This thesis covers the reconstruction and the redesign of the modeling library VehProLib,which is constructed in the modeling language Modelica with help of the modeling toolWolfram SystemModeler. The design choices are discussed and implemented. This thesisalso includes the implementation of a turbocharger package and an initial study of the justificationof the ideal gas law in vehicle modeling. The study is made with help of Van derWaals equation of states as a reference of non-ideal gas mo...

National Libraries Section. General Research Libraries Division. Papers.

Science.gov (United States)

International Federation of Library Associations, The Hague (Netherlands).

Papers on national library services and activities, which were presented at the 1983 International Federation of Library Associations (IFLA) conference, include: (1) "The National Library of China in its Gradual Application of Modern Technology," a discussion by Zhu Nan and Zhu Yan (China) of microform usage and library automation; (2)…

Library 2.0: Service for the Next-Generation Library

Science.gov (United States)

Casey, Michael E.; Savastinuk, Laura C.

2006-01-01

Libraries are changing. Funding limits and customer demands are transforming staffing levels, service models, access to resources, and services to the public. Administrators and taxpayers are seeking more efficient ways of delivering services to achieve greater returns on financial investments. In this article, the author discusses the benefits of…

ILP-2 modeling and virtual screening of an FDA-approved library:a possible anticancer therapy.

Science.gov (United States)

Khalili, Saeed; Mohammadpour, Hemn; Shokrollahi Barough, Mahideh; Kokhaei, Parviz

2016-06-23

The members of the inhibitors of apoptosis protein (IAP) family inhibit diverse components of the caspase signaling pathway, notably caspase 3, 7, and 9. ILP-2 (BIRC-8) is the most recently identified member of the IAPs, mainly interacting with caspase 9. This interaction would eventually lead to death resistance in the case of cancerous cells. Therefore, structural modeling of ILP-2 and finding applicable inhibitors of its interaction with caspase 9 are a compelling challenge. Three main protein modeling approaches along with various model refinement measures were harnessed to achieve a reliable 3D model, using state-of-the-art software. Thereafter, the selected model was employed to perform virtual screening of an FDA approved library. A model built by a combinatorial approach (homology and ab initio approaches) was chosen as the best model. Model refinement processes successfully bolstered the model quality. Virtual screening of the compound library introduced several high affinity inhibitor candidates that interact with functional residues of ILP2. Given the 3D structure of the ILP2 molecule, we found promising inhibitory molecules. In addition to high affinity towards the ILP2 molecule, these molecules interact with residues that play pivotal rules in ILP2-caspase interaction. These molecules would inhibit ILP2-caspase interaction and consequently would lead to reactivated cell apoptosis through the caspases pathway.

The Weapons Laboratory Technical Library: Automating with ’Stilas’

Science.gov (United States)

1990-03-01

version of the system to LC in October 1988. -X- A small business specializing in library automation, SIRSI was founded in 1979 by library and...computer specialists, and has a strong reputation based upon the success of their UNIX-based Unicorn Collection Management System. SIRSI offers a complete...system based on the Unicorn and BRS/ Search systems. The contracted STILAS package includes UNISYS hardware, software written in the C language

DNApi: A De Novo Adapter Prediction Algorithm for Small RNA Sequencing Data.

Science.gov (United States)

Tsuji, Junko; Weng, Zhiping

2016-01-01

With the rapid accumulation of publicly available small RNA sequencing datasets, third-party meta-analysis across many datasets is becoming increasingly powerful. Although removing the 3´ adapter is an essential step for small RNA sequencing analysis, the adapter sequence information is not always available in the metadata. The information can be also erroneous even when it is available. In this study, we developed DNApi, a lightweight Python software package that predicts the 3´ adapter sequence de novo and provides the user with cleansed small RNA sequences ready for down stream analysis. Tested on 539 publicly available small RNA libraries accompanied with 3´ adapter sequences in their metadata, DNApi shows near-perfect accuracy (98.5%) with fast runtime (~2.85 seconds per library) and efficient memory usage (~43 MB on average). In addition to 3´ adapter prediction, it is also important to classify whether the input small RNA libraries were already processed, i.e. the 3´ adapters were removed. DNApi perfectly judged that given another batch of datasets, 192 publicly available processed libraries were "ready-to-map" small RNA sequence. DNApi is compatible with Python 2 and 3, and is available at https://github.com/jnktsj/DNApi. The 731 small RNA libraries used for DNApi evaluation were from human tissues and were carefully and manually collected. This study also provides readers with the curated datasets that can be integrated into their studies.

Using Web Services and XML Harvesting to Achieve a Dynamic Web Site. Computers in Small Libraries

Science.gov (United States)

Roberts, Gary

2005-01-01

Exploiting and contextualizing free information is a natural part of library culture. In this column, Gary Roberts, the information systems and reference librarian at Herrick Library, Alfred University in Alfred, NY, describes how to use XML content on a Web site to link to hundreds of free and useful resources. He gives a general overview of the…

LIBRARY SKILL INSTRUCTION IN NIGERIAN ACADEMIC LIBRARIES

African Journals Online (AJOL)

DJFLEX

www.globaljournalseries.com; Info@globaljournalseries.com. LIBRARY SKILL INSTRUCTION IN NIGERIAN ACADEMIC. LIBRARIES. P. C. AZIAGBA AND E. H. UZOEZI. (Received 10, September 2009; Revision Accepted 8, February 2010). ABSTRACT. This survey was undertaken to portray the level of library involvement ...

E-Services in Danish Research Libraries

DEFF Research Database (Denmark)

Scupola, Ada

2008-01-01

This chapter reports the findings of a case study of e-services adoption at research libraries. The case under consideration is Roskilde University Library (RUB), a research library supporting learning activities at Roskilde University. The research focuses on the main issues that RUB had to deal...... research libraries in Denmark. The main results can be summarized as follows: 1) Adoption of e-services has forced RUB to innovate rapidly. Innovation is driven, among other factors, by ICT developments (technology push), but innovation is also user-driven and pervasive throughout the organization.  2) E...... with in the process of adopting e-services and the future challenges that e-services provide for RUB. The chapter also presents the consequences of e-services adoption for Roskilde University library's organization, its business model and the relationships with customers, publishers (providers of knowledge) and other...

Analysis of LFM-waveform Libraries for Cognitive Tracking Maneuvering Targets

Directory of Open Access Journals (Sweden)

Wang Hongyan

2016-01-01

Full Text Available Based on the idea of the waveform agility in cognitive radars，the waveform libraries for maneuvering target tracking are discussed. LFM-waveform libraries are designed according to different combinations of chirp parameters and FrFT rotation angles. By applying the interact multiple model (IMM algorithm in tracking maneuvering targets, transmitted waveform is called real time from the LFM-waveform libraries. The waveforms are selected from the library according to the criterion of maximum mutual information between the current state of knowledge of the model and the measurement. Simulation results show that waveform library containing certain amount LFM-waveforms can improve the performance of cognitive tracking radar.

E-library Implementation in Library University of Riau

Science.gov (United States)

Yuhelmi; Rismayeti

2017-12-01

This research aims to see how the e-book implementation in Library University of Riau and the obstacle in its implementation. In the Globalization era, digital libraries should be developed or else it will decrease the readers’ interest, with the recent advanced technology, digital libraries are one of the learning tools that can be used to finding an information through the internet access, hence digital libraries or commonly known as E-Library is really helping the students and academic community in finding information. The methods that used in this research is Observation, Interview, and Literature Study. The respondents in this research are the staff who involved in the process of digitization in Library University of Riau. The result of this research shows that implementation of e-library in Library University of Riau is already filled the user needs for now, although there is obstacle faced just like technical problems for example the internet connection speed and the technical problem to convert the format from Microsoft Word .doc to Adobe.pdf

Differences between cross-section libraries for neutron dosimetry

International Nuclear Information System (INIS)

Tardelli, T.C.; Stecher, L.C.; Coelho, T.S.; Castro, V.A. De; Cavalieri, T.A.; Menzel, F.; Giarola, R.S.; Domingos, D.B.; Yoriyaz, H.

2013-01-01

Absorbed dose calculations depend on a consistent set of nuclear data used in simulations in computer codes. Nuclear data are stored in libraries, however, the information available about the differences in dose caused by different libraries are rare. The libraries are processed by a computer system to be able to be used by a radiation transport code. One of the systems capable of processing nuclear data is the NJOY system. The objective of this study is to evaluate the nuclear data libraries for neutrons available in the literature, and to quantify the differences in absorbed dose obtained using the libraries JENDL 4.0, JEFF 3.3.1 and ENDF/B.VII. The absorbed dose calculation was performed on a simple geometric model, as spheres, and in anthropomorphic model of the human body based on the ICRP-110 for neutron transport simulation using the MCNP5 code. The results were compared with literature data. The results obtained with cross sections from the libraries JEFF and ENDF/B.VII have shown to be identical in most cases, except for one case where the difference has exceeded 10%. The results obtained with JENDL library has shown to be considerably different in most cases comparing to other two libraries. Some differences were over 200%. The dose calculations showed differences between the libraries, which is justified by differences in the cross sections. It has been observed that the cross sections values of certain nuclides assume quite different values in different libraries. These differences in turn cause considerable differences in dose calculations. (author)

Three-Dimensional (3D) Printers in Libraries: Perspective and Preliminary Safety Analysis

Science.gov (United States)

Bharti, Neelam; Singh, Shailendra

2017-01-01

As an emerging technology, three-dimensional (3D) printing has gained much attention as a rapid prototyping and small-scale manufacturing technology around the world. In the changing scenario of library inclusion, Makerspaces are becoming a part of most public and academic libraries, and 3D printing is one of the technologies included in…

Library of Congress Model, Perspective View

Science.gov (United States)

2004-01-01

The Shuttle Radar Topography Mission (SRTM) has produced the first high-resolution, near-global elevation dataset of Earth. In recognition of this achievement, and as an illustration of the data, the United States Library of Congress now displays a 'solid terrain model' of Los Angeles and adjacent mountainous terrain. The model was created by carving a high-density foam block using computer-guided drills that referenced the SRTM dataset. The block was then covered with a Landsat satellite image using computer-guided paint guns that referenced both the Landsat image and the SRTM dataset. The view shown here mimics the actual model on display at the Library of Congress and was generated from the same satellite image and elevation data sets. The model shows the Pacific Ocean and Santa Monica Mountains along the Malibu Coast (lower left), San Fernando Valley (left center), downtown Los Angeles (bottom center), San Gabriel and Pomona Valleys (lower right), San Gabriel Mountains (right center to far right), and part of the Mojave Desert (upper right). Colors are enhanced true color with added topographic shading, and elevation differences are exaggerated 1.5 times. The view is toward the north-northwest. The Los Angeles region was chosen for the Library of Congress model because it illustrates so many ways that topography affects the daily lives of people. The region consists of a coastal plain, inland valleys, mountains up to 3068 meters (10,064 feet), and a desert interior. Topography blocks the landward influence of marine airmasses here such that summer temperatures often differ by 40 degrees Fahrenheit (22 C) across this region at a given moment even at similar elevations. Temperatures also typically cool with rising elevation, and winter storms drop most of their moisture in the mountains, leaving little rainfall for areas further inland, thus creating the deserts. Topography also controls the land use pattern. The mountains are mostly very rugged, which greatly

Marketing library and information services in academic libraries in ...

African Journals Online (AJOL)

Marketing library and information services in academic libraries in Niger State, Nigeria. ... This study was designed to investigate the marketing of library services in academic libraries in Niger state, ... EMAIL FULL TEXT EMAIL FULL TEXT

Modelica Library for Building Heating, Ventilation and Air-Conditioning Systems

Energy Technology Data Exchange (ETDEWEB)

Wetter, Michael

2009-06-17

This paper presents a freely available Modelica library for building heating, ventilation and air conditioning systems. The library is based on the Modelica.Fluid library. It has been developed to support research and development of integrated building energy and control systems. The primary applications are controls design, energy analysis and model-based operation. The library contains dynamic and steady-state component models that are applicable for analyzing fast transients when designing control algorithms and for conducting annual simulations when assessing energy performance. For most models, dimensional analysis is used to compute the performance for operating points that differ from nominal conditions. This allows parameterizing models in the absence of detailed geometrical information which is often impractical to obtain during the conceptual design phase of building systems. In the first part of this paper, the library architecture and the main classes are described. In the second part, an example is presented in which we implemented a model of a hydronic heating system with thermostatic radiator valves and thermal energy storage.

Rapid transformation of two libraries using Kotter's Eight Steps of Change.

Science.gov (United States)

Wheeler, Terrie R; Holmes, Kristi L

2017-07-01

Two new directors were each charged by their institutions to catalyze transformational change in their libraries and to develop dynamic and evolving information ecosystems ready for the information challenges of the future. The directors approached this transformational change using a strategic, forward-looking approach. This paper presents examples of actions that served as catalysts for change at the two libraries using Kotter's Eight Steps of Change as a framework. Small and large changes are critical for successfully transforming library services, resources, and personnel. Libraries are faced with incredible pressure to adapt to meet emerging and intensifying information needs on today's academic medical campuses. These pressures offer an opportunity for libraries to accelerate their evolution at the micro and macro levels. This commentary reports the expansion of new services and areas of support, enhancement of professional visibility of the libraries on their campuses, and overall, a more positive and productive environment at the respective institutions.

Active Learning and Teaching: Improving Postsecondary Library Instruction.

Science.gov (United States)

Allen, Eileen E.

1995-01-01

Discusses ways to improve postsecondary library instruction based on theories of active learning. Topics include a historical background of active learning; student achievement and attitudes; cognitive development; risks; active teaching; and instructional techniques, including modified lectures, brainstorming, small group work, cooperative…

Personal Virtual Libraries

Science.gov (United States)

Pappas, Marjorie L.

2004-01-01

Virtual libraries are becoming more and more common. Most states have a virtual library. A growing number of public libraries have a virtual presence on the Web. Virtual libraries are a growing addition to school library media collections. The next logical step would be personal virtual libraries. A personal virtual library (PVL) is a collection…

Progress on chinese evaluated nuclear parameter library: Pt.5

Energy Technology Data Exchange (ETDEWEB)

Zongdi, Su; Zhongfu, Huang; Jianfeng, Liu [and others

1996-06-01

The progress on chinese evaluated nuclear parameter library (v) was introduced. Six sub-libraries, MCC, DLS, NLD, GDP, FBP and OMP, including their data files and management-retrieval code systems have all been finished. All six sub-libraries have been used in nuclear model calculations, nuclear data evaluations and other fields in China. The applied results show that our evaluated nuclear parameter library is satisfactory and convenient.

Design of focused and restrained subsets from extremely large virtual libraries.

Science.gov (United States)

Jamois, Eric A; Lin, Chien T; Waldman, Marvin

2003-11-01

With the current and ever-growing offering of reagents along with the vast palette of organic reactions, virtual libraries accessible to combinatorial chemists can reach sizes of billions of compounds or more. Extracting practical size subsets for experimentation has remained an essential step in the design of combinatorial libraries. A typical approach to computational library design involves enumeration of structures and properties for the entire virtual library, which may be unpractical for such large libraries. This study describes a new approach termed as on the fly optimization (OTFO) where descriptors are computed as needed within the subset optimization cycle and without intermediate enumeration of structures. Results reported herein highlight the advantages of coupling an ultra-fast descriptor calculation engine to subset optimization capabilities. We also show that enumeration of properties for the entire virtual library may not only be unpractical but also wasteful. Successful design of focused and restrained subsets can be achieved while sampling only a small fraction of the virtual library. We also investigate the stability of the method and compare results obtained from simulated annealing (SA) and genetic algorithms (GA).

A protein-dependent side-chain rotamer library.

KAUST Repository

Bhuyan, M.S.; Gao, Xin

2011-01-01

Protein side-chain packing problem has remained one of the key open problems in bioinformatics. The three main components of protein side-chain prediction methods are a rotamer library, an energy function and a search algorithm. Rotamer libraries summarize the existing knowledge of the experimentally determined structures quantitatively. Depending on how much contextual information is encoded, there are backbone-independent rotamer libraries and backbone-dependent rotamer libraries. Backbone-independent libraries only encode sequential information, whereas backbone-dependent libraries encode both sequential and locally structural information. However, side-chain conformations are determined by spatially local information, rather than sequentially local information. Since in the side-chain prediction problem, the backbone structure is given, spatially local information should ideally be encoded into the rotamer libraries. In this paper, we propose a new type of backbone-dependent rotamer library, which encodes structural information of all the spatially neighboring residues. We call it protein-dependent rotamer libraries. Given any rotamer library and a protein backbone structure, we first model the protein structure as a Markov random field. Then the marginal distributions are estimated by the inference algorithms, without doing global optimization or search. The rotamers from the given library are then re-ranked and associated with the updated probabilities. Experimental results demonstrate that the proposed protein-dependent libraries significantly outperform the widely used backbone-dependent libraries in terms of the side-chain prediction accuracy and the rotamer ranking ability. Furthermore, without global optimization/search, the side-chain prediction power of the protein-dependent library is still comparable to the global-search-based side-chain prediction methods.

A protein-dependent side-chain rotamer library.

KAUST Repository

Bhuyan, M.S.

2011-12-14

Protein side-chain packing problem has remained one of the key open problems in bioinformatics. The three main components of protein side-chain prediction methods are a rotamer library, an energy function and a search algorithm. Rotamer libraries summarize the existing knowledge of the experimentally determined structures quantitatively. Depending on how much contextual information is encoded, there are backbone-independent rotamer libraries and backbone-dependent rotamer libraries. Backbone-independent libraries only encode sequential information, whereas backbone-dependent libraries encode both sequential and locally structural information. However, side-chain conformations are determined by spatially local information, rather than sequentially local information. Since in the side-chain prediction problem, the backbone structure is given, spatially local information should ideally be encoded into the rotamer libraries. In this paper, we propose a new type of backbone-dependent rotamer library, which encodes structural information of all the spatially neighboring residues. We call it protein-dependent rotamer libraries. Given any rotamer library and a protein backbone structure, we first model the protein structure as a Markov random field. Then the marginal distributions are estimated by the inference algorithms, without doing global optimization or search. The rotamers from the given library are then re-ranked and associated with the updated probabilities. Experimental results demonstrate that the proposed protein-dependent libraries significantly outperform the widely used backbone-dependent libraries in terms of the side-chain prediction accuracy and the rotamer ranking ability. Furthermore, without global optimization/search, the side-chain prediction power of the protein-dependent library is still comparable to the global-search-based side-chain prediction methods.

America's Star Libraries

Science.gov (United States)

Lyons, Ray; Lance, Keith Curry

2009-01-01

"Library Journal"'s new national rating of public libraries, the "LJ" Index of Public Library Service, identifies 256 "star" libraries. It rates 7,115 public libraries. The top libraries in each group get five, four, or three Michelin guide-like stars. All included libraries, stars or not, can use their scores to learn from their peers and improve…

Erik Gunnar Asplund’s Stockholm Public Library

DEFF Research Database (Denmark)

Andersen, Michael Asgaard

2017-01-01

Stockholm Public Library, which opened on March 31, 1928, was in many ways an innovation in the Nordic countries. Most striking was the fact that lenders could now take books off the shelves themselves, but the central placement of the lending room and the secondary placement of the reading rooms...... also indicated a new way to do libraries. The thoughts embodied in the building became a model for many later libraries. The building is not only testimony to an important period of Nordic architectural history and a recognized masterpiece by the Swedish architect Erik Gunnar Asplund (1885......–1940), it is also part of the history of the Nordic social model that was taking shape in the interwar years. By its function as a public institution and its unique architectural qualities, Stockholm Public Library today stands as an important work of Nordic welfare building....

Closing small open economy models

OpenAIRE

Schmitt-Grohe, Stephanie; Uribe, Martín

2001-01-01

The small open economy model with incomplete asset markets features a steady state that depends on initial conditions and equilibrium dynamics that possess a random walk component. A number of modifications to the standard model have been proposed to induce stationarity. This paper presents a quantitative comparison of these alternative approaches. Five different specifications are considered: (1) A model with an endogenous discount factor (Uzawa-type preferences); (2) A model with a debt-ela...

Efficient Management of High-Throughput Screening Libraries with SAVANAH

DEFF Research Database (Denmark)

List, Markus; Elnegaard, Marlene Pedersen; Schmidt, Steffen

2017-01-01

) sample information from the library to experimental results from the assay plates. All results can be exported to the R statistical environment or piped into HiTSeekR (http://hitseekr.compbio.sdu.dk) for comprehensive follow-up analyses. In summary, SAVANAH supports the HTS community in managing...... for such screens are molecular libraries, that is, microtiter plates with solubilized reagents such as siRNAs, shRNAs, miRNA inhibitors or mimics, and sgRNAs, or small compounds, that is, drugs. These reagents are typically condensed to provide enough material for covering several screens. Library plates thus need...... to be serially diluted before they can be used as assay plates. This process, however, leads to an explosion in the number of plates and samples to be tracked. Here, we present SAVANAH, the first tool to effectively manage molecular screening libraries across dilution series. It conveniently links (connects...

  Cell Penetrating Peptoids (CPPos: Synthesis of a Small Combinatorial Library by Using IRORI MiniKans

Directory of Open Access Journals (Sweden)

Dominik K. Kölmel

2012-11-01

Full Text Available Cell penetrating peptoids (CPPos are potent mimics of the corresponding cell penetrating peptides (CPPs. The synthesis of diverse oligomeric libraries that display a variety of backbone scaffolds and side-chain appendages are a very promising source of novel CPPos, which can be used to either target different cellular organelles or even different tissues and organs. In this study we established the submonomer-based solid phase synthesis of a “proof of principle” peptoid library in IRORI MiniKans to expand the amount for phenotypic high throughput screens of CPPos. The library consisting of tetrameric peptoids [oligo(N-alkylglycines] was established on Rink amide resin in a split and mix approach with hydrophilic and hydrophobic peptoid side chains. All CPPos of the presented library were labeled with rhodamine B to allow for the monitoring of cellular uptake by fluorescent confocal microscopy. Eventually, all the purified peptoids were subjected to live cell imaging to screen for CPPos with organelle specificity. While highly charged CPPos enter the cells by endocytosis with subsequent endosomal release, critical levels of lipophilicity allow other CPPos to specifically localize to mitochondria once a certain lipophilicity threshold is reached.

CHALLENGES AROUND DIGITAL BOOK LENDING LIBRARY

Directory of Open Access Journals (Sweden)

Julio Alonso-Arévalo

2015-03-01

Full Text Available The development and expansion of the global market for electronic books and associated models to lending library are still in a developmental state and uncertainty. After a first stage in which major publishers refused to sell licenses loan at present publishers are putting more e-book titles available to libraries, although with some restrictions. The dominant trend is moving inexorably towards greater availability and access to digital titles to libraries. Once this stage about the limited availability of titles are pending other matters as the issue of licensing costs, with different rates offered to the public, which are increased in some cases up to three or more sometimes the retail price, which further complicates the procurement processes for libraries in a time when budgets are limited, hampering the ability of libraries to acquire adequate collection of digital products. Among other issues, technological and commercial that limit many uses they had libraries in the analog context, ownership and possession of the collection, the same stability, portability across platforms, and the difficulties associated with DRM systems digital rights management.

Lack of Annual Reports Make it Difficult to Analyze Library Strategic Credibility. A Review of: Staines, G. (2009. Towards an assessment of strategic credibility in academic libraries. Library Management, 30(3, 148-162.

Directory of Open Access Journals (Sweden)

Kirsty Thomson

2011-06-01

Full Text Available Objective – To investigate whether libraries achieve strategic credibility by assessing if strategic planning goals match the achievements described in annual reports.Design – Content analysis of annual reports and strategic plans from a sample of Association of Research Libraries (ARL.Setting – Academic libraries in Canada and the United States of America.Subjects – A random sample of 12 Canadian and 16 American academic libraries. All libraries were members of ARL.Methods – The researcher contacted the directors of 28 ARL libraries and asked for copies of their strategic plans and annual reports. She also visited the websites of libraries to obtain the reports. The contents of the strategic plans and annual reports were analyzed, and trends in the Canadian and American strategic plans were identified.Main Results – This study found that only 39% of ARL libraries produce annual reports, making it difficult to assess if libraries have strategic credibility, as their strategic plans cannot be assessed against annual reports. The strategic plans gathered in this study were analyzed and emerging themes were identified. These included physical library space (renovations, expansions or new buildings; offsite storage; assessment (both of the libraries’ services, and of information literacy training; development activities such as fundraising and marketing; and personnel issues. Cultural differences also were found inthe strategic plans, with American libraries being more focused on trends such as digitization and institutional repositories, andCanadian libraries’ plans being more focused on users’ needs. Trends in annual reports were not reported due to the small number ofannual reports in the sample.Conclusion – This study gives a snapshot ofthe trends in strategic plans of ARL members. It shows that many ARL members do not produce an annual report, and that it istherefore difficult to assess if their strategicplans are

More library mashups exploring new ways to deliver library data

CERN Document Server

2015-01-01

Nicole Engard follows up her ground-breaking 2009 book Library Mashups with a fresh collection of mashup projects that virtually any library can emulate, customize, and build upon. In More Library Mashups, Engard and 24 creative library professionals describe how they are mashing up free and inexpensive digital tools and techniques to improve library services and meet everyday (and unexpected) challenges. Examples from libraries of all types are designed to help even non-programmers share and add value to digital content, update and enhance library websites and collections, mashup catalog data, connect to the library's automation system, and use emerging tools like Serendip-o-matic, Umlaut, and Libki to engage users, staff, and the community.

Towards C++ object libraries for accelerator physics

International Nuclear Information System (INIS)

Michelotti, L.

1992-01-01

This paper concerns creation of libraries of reusable objects in the language C ++ for doing accelerator design and analysis. The C ++ language possesses features which lend themselves to writing portable, scientific solftware. The two libraries of C ++ classes (objects) which have been under development are (1) MXYZPTLK, which implements automatic differentiation and (2) BEAMLINE, which provides objects for modeling beam line and accelerator components. A description of the principle classes in these two libraries is presented

Evaluation of a Digital Library by Means of Quality Function Deployment (QFD) and the Kano Model

Science.gov (United States)

Garibay, Cecilia; Gutierrez, Humberto; Figueroa, Arturo

2010-01-01

This paper proposes utilizing a combination of the Quality Function Deployment (QFD)-Kano model as a useful tool to evaluate service quality. The digital library of the University of Guadalajara (Mexico) is presented as a case study. Data to feed the QFD-Kano model was gathered by an online questionnaire that was made available to users on the…

A Framework for Studying Organizational Innovation in Research Libraries

Science.gov (United States)

Jantz, Ronald C.

2012-01-01

The objective of this paper is two-fold: to propose a theoretical framework and model for studying organizational innovation in research libraries and to set forth propositions that can provide directions for future empirical studies of innovation in research libraries. Research libraries can be considered members of a class of organizations…

Library Science Education: A New Role for Academic Libraries

Science.gov (United States)

Wesley, Threasa L.

2018-01-01

Many individuals working in library and information organizations do not hold a master of library science (MLS) degree or other specialized library science credential. Recognizing that this professional gap could be addressed by diversified educational opportunities, the W. Frank Steely Library at Northern Kentucky University in Highland Heights…

Evaluation of usability of Spanish academic library web portals using a cognitive-emotional heuristic model

Directory of Open Access Journals (Sweden)

Daniel Muñoz-Egido

2017-03-01

Full Text Available In this paper a cognitive-emotional usability analysis model based on heuristics was used to analyze eighteen academic library web portals. Starting with a review of existing literature on the subject, a set of seventy-one heuristic criteria grouped into six aspects was designed, to which the metrics developed by SIRIUS were applied. The result of the evaluation reveals that the average usability of websites of university libraries analyzed stands at 72.30 over 100 with a standard deviation of 5.57. The aspects with the lowest scores were Attention and Long Term Memory and Learning, which were therefore approached less satisfactorily from the user’s point of view.

A Model of Building Multi-campus Library Education Ｒesourses Network Based on MPLS VPN

Directory of Open Access Journals (Sweden)

WANG Guang-ze

2017-06-01

Full Text Available For the problems of most merged schools that it is difficulty to integrate the original library education resources network due to scattered campus，and it is inconvenient to use teaching resources for outwork teachers and students，this paper puts forward the technology of using multi － protocol label switching virtual private network ( MPLS VPN to integrate education resources in multi － campus library． Through setting up security tunnel between the library education subnet，MPLS VPN ensure the safety of data transmission，so as achieve the goal of resource integration，optimization and share，implements the exclusive use for the electronic teaching business of library． Experimental data show that this model has advantages compared with traditional VPN networking．

General Maister's Library in the University of Maribor Library: Gaining and Preservation of the General Maister's Private Library in the University of Maribor Library

Directory of Open Access Journals (Sweden)

Vlasta Stavbar

2015-12-01

Full Text Available Rudolf Maister’s book legacy, which is kept in the University of Maribor Library, is the complete legacy of the Maister’s private book collection– the “maistirana”. The Maister’s Library is in the University of Maribor Library possession since 1998, when General Maister’s heirs and the Library signed the deed of donation. 5.945 units of library materials present a special collection, which is divided from the regular library holdings and is kept in a specially designed room. General Maister’s Library is an exception in the University of Maribor Library, since the general practice of libraries is not an exclusive maintenance of the provenience principle and of the original organisation. Because the Maister’s Library consists of materials that are important when researching the Slovene literary and cultural past, it only seems reasonably to strive for the authentic organisation and preserving the library as one integral whole.In order to understand the meaning and the importance of this special library collection for the Slovene cultural heritage, we have to highlight Rudolf Maister as a passionate book lover and as the owner of one of the greatest and the most beautiful private libraries in Slovenia. General Maister started collecting books and organising his collection back in 1912 in Ljubljana; the collection was rearranged thoroughly during the time he was in Maribor; it survived the moves during World War II and after it and it finally found its place in the General Maister’s Library under the patronage of the University of Maribor Library. The rearranging of the shelving system and sorting of the materials patterned after the authentic shelving system in the General’s Maribor apartment took place in 2013. Until then the books were not arranged according to the authentic shelving system. The estimated shelving system reconstruction has reconstructed Maister’s shelving system as authentically as possible, for it is not

Library usage patterns in the electronic information environment. Electronic journals, Use studies, Libraries, Medical libraries

Directory of Open Access Journals (Sweden)

B. Franklin

2004-01-01

Full Text Available This paper examines the methodology and results from Web-based surveys of more than 15,000 networked electronic services users in the United States between July 1998 and June 2003 at four academic health sciences libraries and two large main campus libraries serving a variety of disciplines. A statistically valid methodology for administering simultaneous Web-based and print-based surveys using the random moments sampling technique is discussed and implemented. Results from the Web-based surveys showed that at the four academic health sciences libraries, there were approximately four remote networked electronic services users for each in-house user. This ratio was even higher for faculty, staff, and research fellows at the academic health sciences libraries, where more than five remote users for each in-house user were recorded. At the two main libraries, there were approximately 1.3 remote users for each in-house user of electronic information. Sponsored research (grant funded research accounted for approximately 32% of the networked electronic services activity at the health sciences libraries and 16% at the main campus libraries. Sponsored researchers at the health sciences libraries appeared to use networked electronic services most intensively from on-campus, but not from in the library. The purpose of use for networked electronic resources by patrons within the library is different from the purpose of use of those resources by patrons using the resources remotely. The implications of these results on how librarians reach decisions about networked electronic resources and services are discussed.

Improvements on burnup chain model and group cross section library in the SRAC system

International Nuclear Information System (INIS)

Akie, Hiroshi; Okumura, Keisuke; Takano, Hideki; Ishiguro, Yukio; Kaneko, Kunio.

1992-01-01

Data and functions of the cell burnup calculation of the SRAC system were revised to improve mainly the accuracy of the burnup calculation of high conversion light water reactors (HCLWRs). New burnup chain models were developed in order to treat fission products (FPs) and actinide nuclides in detail. Group cross section library, SRACLIB-JENDL2, was generated based on JENDL-2 nuclear data file. In generating this library, emphasis was placed on FPs and actinides. Also revised were the data such as the average energy release per fission for various actinides. These improved data were verified by performing the burnup analysis of PWR spent fuels. Some new functions were added to the SRAC system for the convenience to yield macroscopic cross sections used in the core burnup process. (author)

A Case Study of a Rural Iowa School Preparing to Meet New State Guidelines for School Libraries

Science.gov (United States)

Krueger, Karla Steege

2009-01-01

A qualitative case study highlighting one rural Iowa elementary school provided insight into the issue of small schools without library programs as they are preparing to meet the Iowa reinstatement of the requirement for school library programs. The site was purposefully chosen because it has been operating without a school library program or…

Deep-sequencing protocols influence the results obtained in small-RNA sequencing.

Directory of Open Access Journals (Sweden)

Joern Toedling

Full Text Available Second-generation sequencing is a powerful method for identifying and quantifying small-RNA components of cells. However, little attention has been paid to the effects of the choice of sequencing platform and library preparation protocol on the results obtained. We present a thorough comparison of small-RNA sequencing libraries generated from the same embryonic stem cell lines, using different sequencing platforms, which represent the three major second-generation sequencing technologies, and protocols. We have analysed and compared the expression of microRNAs, as well as populations of small RNAs derived from repetitive elements. Despite the fact that different libraries display a good correlation between sequencing platforms, qualitative and quantitative variations in the results were found, depending on the protocol used. Thus, when comparing libraries from different biological samples, it is strongly recommended to use the same sequencing platform and protocol in order to ensure the biological relevance of the comparisons.

Library Subject Guides: A Case Study of Evidence-Informed Library Development

Science.gov (United States)

Wakeham, Maurice; Roberts, Angharad; Shelley, Jane; Wells, Paul

2012-01-01

This paper describes the process whereby a university library investigated the value of its subject guides to its users. A literature review and surveys of library staff, library users and other libraries were carried out. Existing library subject guides and those of other higher education libraries were evaluated. The project team reported…

Scientific Digital Libraries, Interoperability, and Ontologies

Science.gov (United States)

Hughes, J. Steven; Crichton, Daniel J.; Mattmann, Chris A.

2009-01-01

Scientific digital libraries serve complex and evolving research communities. Justifications for the development of scientific digital libraries include the desire to preserve science data and the promises of information interconnectedness, correlative science, and system interoperability. Shared ontologies are fundamental to fulfilling these promises. We present a tool framework, some informal principles, and several case studies where shared ontologies are used to guide the implementation of scientific digital libraries. The tool framework, based on an ontology modeling tool, was configured to develop, manage, and keep shared ontologies relevant within changing domains and to promote the interoperability, interconnectedness, and correlation desired by scientists.

Librarians and Libraries Supporting Open Access Publishing

Science.gov (United States)

Richard, Jennifer; Koufogiannakis, Denise; Ryan, Pam

2009-01-01

As new models of scholarly communication emerge, librarians and libraries have responded by developing and supporting new methods of storing and providing access to information and by creating new publishing support services. This article will examine the roles of libraries and librarians in developing and supporting open access publishing…

Empirical spatial econometric modelling of small scale neighbourhood

Science.gov (United States)

Gerkman, Linda

2012-07-01

The aim of the paper is to model small scale neighbourhood in a house price model by implementing the newest methodology in spatial econometrics. A common problem when modelling house prices is that in practice it is seldom possible to obtain all the desired variables. Especially variables capturing the small scale neighbourhood conditions are hard to find. If there are important explanatory variables missing from the model, the omitted variables are spatially autocorrelated and they are correlated with the explanatory variables included in the model, it can be shown that a spatial Durbin model is motivated. In the empirical application on new house price data from Helsinki in Finland, we find the motivation for a spatial Durbin model, we estimate the model and interpret the estimates for the summary measures of impacts. By the analysis we show that the model structure makes it possible to model and find small scale neighbourhood effects, when we know that they exist, but we are lacking proper variables to measure them.

Zoo and Wildlife Libraries: An International Survey

Science.gov (United States)

Coates, Linda L.; Tierney, Kaitlyn Rose

2010-01-01

The conservation and well-being of exotic animals is core to the mission of zoos, aquariums and many small nonprofit wildlife groups. Increasingly, these organizations are committed to scientific research, both basic and applied. To ascertain the current state of the libraries that support their efforts, librarians at the San Diego Zoo conducted…

Library subject guides: A case study of evidence-informed library development

OpenAIRE

Wakeham, Maurice; Roberts, Angharad; Shelley, Jane; Wells, Paul

2012-01-01

This paper describes the process whereby a university library investigated the value of its subject guides to its users. A literature review and surveys of library staff, library users and other libraries were carried out. Existing library subject guides and those of other higher education libraries were evaluated. The project team reported regularly to the wider library team throughout the year long investigation and made recommendations. The project served to develop the professional skills...

Computational mass spectrometry for small molecules

Science.gov (United States)

2013-01-01

The identification of small molecules from mass spectrometry (MS) data remains a major challenge in the interpretation of MS data. This review covers the computational aspects of identifying small molecules, from the identification of a compound searching a reference spectral library, to the structural elucidation of unknowns. In detail, we describe the basic principles and pitfalls of searching mass spectral reference libraries. Determining the molecular formula of the compound can serve as a basis for subsequent structural elucidation; consequently, we cover different methods for molecular formula identification, focussing on isotope pattern analysis. We then discuss automated methods to deal with mass spectra of compounds that are not present in spectral libraries, and provide an insight into de novo analysis of fragmentation spectra using fragmentation trees. In addition, this review shortly covers the reconstruction of metabolic networks using MS data. Finally, we list available software for different steps of the analysis pipeline. PMID:23453222

Patricia Knapp’s Landmark Project to Develop a Plan of Curriculum-Integrated Library Instruction. A review of: Knapp, P. B. (1966. The Monteith College library experiment. New York, NY: Scarecrow Press.

Directory of Open Access Journals (Sweden)

Carol D. Howe

2011-03-01

Full Text Available Objective – To create a college-level, four-year plan of library instruction in which assignments directly relate to students’ course work. To develop tools to assess the plan’s effectiveness in improving students’ library skills and contributing to their overall academic success.Design – Exploratory longitudinal cohort study employing pilot library assignments, interviews, and questionnaires.Setting – Monteith College, one of eleven colleges at Wayne State University. Monteith was a small liberal arts college established in 1959 which stressed innovative teaching methods such as team-teaching, small-group discussion, and independent study (Worrell, 2002.Subjects – Teaching faculty from all three college divisions—social sciences, natural sciences, and humanities—and students at Monteith College. Over the course of the study the college employed between 15 and 30 faculty members and enrolled 300 to 700 students.Methods – The project team consisted of project director Patricia Knapp, a project librarian, and a project research analyst. The team worked with the teaching faculty to develop course-related library assignments. Students completed a series of assignments over several semesters as part of their course requirements. The assignment series changed over the course of the project. Students who entered in the fall of 1959 or the spring of 1960 completed Sequence A consisting of six assignments. Students who entered in the fall of 1960 completed Sequence B, six assignments that were a mixture of original and revised assignments. Students who entered in the spring or fall of 1961 completed two revised library assignments.In the summer of 1961, the investigators conducted the first of two small studies. They interviewed a random sample of 21 Monteith students about their experiences with the library and the required library assignments. The students also completed library performance tests such as choosing a subject heading

Small Animal Models for Evaluating Filovirus Countermeasures.

Science.gov (United States)

Banadyga, Logan; Wong, Gary; Qiu, Xiangguo

2018-05-11

The development of novel therapeutics and vaccines to treat or prevent disease caused by filoviruses, such as Ebola and Marburg viruses, depends on the availability of animal models that faithfully recapitulate clinical hallmarks of disease as it is observed in humans. In particular, small animal models (such as mice and guinea pigs) are historically and frequently used for the primary evaluation of antiviral countermeasures, prior to testing in nonhuman primates, which represent the gold-standard filovirus animal model. In the past several years, however, the filovirus field has witnessed the continued refinement of the mouse and guinea pig models of disease, as well as the introduction of the hamster and ferret models. We now have small animal models for most human-pathogenic filoviruses, many of which are susceptible to wild type virus and demonstrate key features of disease, including robust virus replication, coagulopathy, and immune system dysfunction. Although none of these small animal model systems perfectly recapitulates Ebola virus disease or Marburg virus disease on its own, collectively they offer a nearly complete set of tools in which to carry out the preclinical development of novel antiviral drugs.

The history and library statistics of JAEA library activities

Energy Technology Data Exchange (ETDEWEB)

Itabashi, Keizo [Japan Atomic Energy Agency, Intellectual Resources Dept., Tokai, Ibaraki (Japan)

2012-03-15

The history and library statistics of the Japan Atomic Energy Agency library activity were summarized. Former Japan Atomic Energy Research Institute and the former Japan Nuclear Cycle Development Institute merged in October, 2005, and Japan Atomic Energy Agency is established. Properly speaking, the library statistics of old two corporations should have been summarized, but statistics of the Japan Nuclear Cycle Development Institute is not yet obtained. Then, although it is stated as the Japan Atomic Energy Agency library, it limits to the description about the old Japan Atomic Energy Research Institute library before 2004. (author)

The history and library statistics of JAEA library activities

International Nuclear Information System (INIS)

Itabashi, Keizo

2012-03-01

The history and library statistics of the Japan Atomic Energy Agency library activity were summarized. Former Japan Atomic Energy Research Institute and the former Japan Nuclear Cycle Development Institute merged in October, 2005, and Japan Atomic Energy Agency is established. Properly speaking, the library statistics of old two corporations should have been summarized, but statistics of the Japan Nuclear Cycle Development Institute is not yet obtained. Then, although it is stated as the Japan Atomic Energy Agency library, it limits to the description about the old Japan Atomic Energy Research Institute library before 2004. (author)

Demand Driven Acquisition of E-Books in a Small Online Academic Library: Growing Pains and Assessing Gains

Science.gov (United States)

Longley, Dana H.

2016-01-01

How does a smaller, fully online academic library offer a wide and deep collection of academic level e-books to its distance learners in a sustainable and affordable way? The State University of New York (SUNY) Empire State College Online Library, with a staff of four, has used demand-driven e-book acquisitions since September 2013. Despite…

Reference Services in Australian Academic Libraries are Becoming More Multifaceted, A Review of: Burke, L. “Models of Reference Services in Australian Academic Libraries.” Journal of Librarianship and Information Science 40.4 (2008: 269‐86.

Directory of Open Access Journals (Sweden)

David Herron

2009-09-01

Full Text Available Objective – To investigate the current organizational models for reference work in Australian academic libraries, and how these reference services are staffed.Design – Mixed methods.Setting – Academic universities in Australia.Subjects – Forty Council of Australian University Librarians (CAUL member libraries.Methods – A literature study was undertaken to (1 find a definition of reference services and (2 explore the development of reference service models over time. Statistics from the CAUL member libraries were studied for trends in student population and number of academic and library staff. A web‐based survey, with questions based on the findings in the literature study, was then distributed to the 40 Australian university libraries in 2006. Respondents were asked when the library commenced different reference services in five areas: formats in which the library received and responded to reference queries, information literacy, subject specialization, liaison activities, and collection development. Respondents also answered questions about the organization of the reference department, including: whether they had a separate or integrated model; the size of the reference collections; if they had a librarian dedicated to supporting students studying in remote or distant mode; if the interlibrary loans department was part of the suite of reference services; and if they had a mission or statement of purpose for their reference services department.Main Results – Based on the literature study, the working definition of reference services (1 for the project was “all activities which assist in providing relevant and appropriate information services to patrons” (270, including:•All interactions with patrons to assist them in their searches for information in all media types.•All training by librarians of patrons to be able to access information for themselves.•Activities to help the library stay informed of relevant developments

A credit-card library approach for disrupting protein-protein interactions.

Science.gov (United States)

Xu, Yang; Shi, Jin; Yamamoto, Noboru; Moss, Jason A; Vogt, Peter K; Janda, Kim D

2006-04-15

Protein-protein interfaces are prominent in many therapeutically important targets. Using small organic molecules to disrupt protein-protein interactions is a current challenge in chemical biology. An important example of protein-protein interactions is provided by the Myc protein, which is frequently deregulated in human cancers. Myc belongs to the family of basic helix-loop-helix leucine zipper (bHLH-ZIP) transcription factors. It is biologically active only as heterodimer with the bHLH-ZIP protein Max. Herein, we report a new strategy for the disruption of protein-protein interactions that has been corroborated through the design and synthesis of a small parallel library composed of 'credit-card' compounds. These compounds are derived from a planar, aromatic scaffold and functionalized with four points of diversity. From a 285 membered library, several hits were obtained that disrupted the c-Myc-Max interaction and cellular functions of c-Myc. The IC50 values determined for this small focused library for the disruption of Myc-Max dimerization are quite potent, especially since small molecule antagonists of protein-protein interactions are notoriously difficult to find. Furthermore, several of the compounds were active at the cellular level as shown by their biological effects on Myc action in chicken embryo fibroblast assays. In light of our findings, this approach is considered a valuable addition to the armamentarium of new molecules being developed to interact with protein-protein interfaces. Finally, this strategy for disrupting protein-protein interactions should prove applicable to other families of proteins.

Wikis in Libraries

Directory of Open Access Journals (Sweden)

Matthew Bejune

2007-09-01

Full Text Available Wikis have recently been adopted to support a variety of collaborative activities within libraries. This article and its companion wiki, LibraryWikis (http://librarywikis.pbwiki.com/, seek to document the phenomenon of wikis in libraries. This subject is considered within the framework of computer-supported cooperative work (CSCW. The author identified thirty-three library wikis and developed a classification schema with four categories: (1 collaboration among libraries (45.7 percent; (2 collaboration among library staff (31.4 percent; (3 collaboration among library staff and patrons (14.3 percent; and (4 collaboration among patrons (8.6 percent. Examples of library wikis are presented within the article, as is a discussion for why wikis are primarily utilized within categories I and II and not within categories III and IV. It is clear that wikis have great utility within libraries, and the author urges further application of wikis in libraries.

Assessment of Insert Sizes and Adapter Content in Fastq Data from NexteraXT Libraries

Directory of Open Access Journals (Sweden)

Frances Susan Turner

2014-01-01

Full Text Available The Illumina NexteraXT transposon protocol is a cost effective way to generate paired end libraries. However the resulting insert size is highly sensitive to the concentration of DNA used, and the variation of insert sizes is often large. One consequence of this is some fragments may have an insert shorter than the length of a single read, particularly where the library is designed to produce overlapping paired end reads in order to produce longer continuous sequences. Such small insert sizes mean fewer longer reads, and also result in the presence of adapter at the end of the read. Here is presented a protocol to use publicly available tools to identify read pairs with small insert sizes and so likely to contain adapter, to check the sequence of the adapter, and remove adapter sequence from the reads. This protocol does not require a reference genome or prior knowledge of the sequence to be trimmed. Whilst the presence of fragments with small insert sizes may be a particular problem for NexteraXT libraries, the principle can be applied to any Illumina dataset in which the presence of such small inserts is suspected.

The AHEC library program and consortia development in California.

Science.gov (United States)

Jensen, M A; Maddalena, B

1986-07-01

A brief history of the first Area Health Education Center (AHEC) Library Program in California is presented, with a description of methodology and results. The goals of this program were to develop and improve hospital library resources and services, to train hospital library personnel, and to promote resource sharing in a medically underserved area. The health sciences library consortium that evolved became a model for the ten other library consortia in the state. Based on AHEC's twelve years' experience with consortia, from 1973 to 1985, recommendations are made as to size, composition, leadership, outside funding, group participation, publicity, and linkages.

Inexpensive multiplexed library preparation for megabase-sized genomes.

Directory of Open Access Journals (Sweden)

Michael Baym

Full Text Available Whole-genome sequencing has become an indispensible tool of modern biology. However, the cost of sample preparation relative to the cost of sequencing remains high, especially for small genomes where the former is dominant. Here we present a protocol for rapid and inexpensive preparation of hundreds of multiplexed genomic libraries for Illumina sequencing. By carrying out the Nextera tagmentation reaction in small volumes, replacing costly reagents with cheaper equivalents, and omitting unnecessary steps, we achieve a cost of library preparation of $8 per sample, approximately 6 times cheaper than the standard Nextera XT protocol. Furthermore, our procedure takes less than 5 hours for 96 samples. Several hundred samples can then be pooled on the same HiSeq lane via custom barcodes. Our method will be useful for re-sequencing of microbial or viral genomes, including those from evolution experiments, genetic screens, and environmental samples, as well as for other sequencing applications including large amplicon, open chromosome, artificial chromosomes, and RNA sequencing.

The Medical Library Association Benchmarking Network: development and implementation.

Science.gov (United States)

Dudden, Rosalind Farnam; Corcoran, Kate; Kaplan, Janice; Magouirk, Jeff; Rand, Debra C; Smith, Bernie Todd

2006-04-01

This article explores the development and implementation of the Medical Library Association (MLA) Benchmarking Network from the initial idea and test survey, to the implementation of a national survey in 2002, to the establishment of a continuing program in 2004. Started as a program for hospital libraries, it has expanded to include other nonacademic health sciences libraries. The activities and timelines of MLA's Benchmarking Network task forces and editorial board from 1998 to 2004 are described. The Benchmarking Network task forces successfully developed an extensive questionnaire with parameters of size and measures of library activity and published a report of the data collected by September 2002. The data were available to all MLA members in the form of aggregate tables. Utilization of Web-based technologies proved feasible for data intake and interactive display. A companion article analyzes and presents some of the data. MLA has continued to develop the Benchmarking Network with the completion of a second survey in 2004. The Benchmarking Network has provided many small libraries with comparative data to present to their administrators. It is a challenge for the future to convince all MLA members to participate in this valuable program.

Status of the JEFF Nuclear Data Library

International Nuclear Information System (INIS)

Koning, A.J.; Bersillon, O.; Forrest, R. A.; Jacqmin, R.; Kellett, M.A.; Nouri, A.; Rullhusen, P.

2005-01-01

The status of the Joint Evaluated Fission and Fusion file (JEFF) is described. The next version of the library, JEFF-3.1, comprises a significant update of actinide evaluations, evaluations emerging from European nuclear data projects, the activation library JEFF-3/A, the decay data and fission yield library, and fusion-related data files from the EFF project. The revisions were motivated by the availability of new measurements, modelling capabilities, or trends from integral experiments. Various pre-release validation efforts are underway, mainly for criticality and shielding of thermal and fast systems. This JEFF-3.1 library is expected to provide improved performances with respect to previous releases for a variety of scientific and industrial applications

Status of the JEFF nuclear data library

International Nuclear Information System (INIS)

Koning, A.J.; Duijvestijn, M.C.; Bersillon, O.; Forrest, R.A.; Jacqmin, R.; Kellett, M.A.; Nouri, A.; Rullhusen, P.

2005-03-01

The status of the Joint Evaluated Fission and Fusion file (JEFF) is described. The next version of the library, JEFF-3.1, comprises a significant update of actinide evaluations, evaluations emerging from European nuclear data projects, the activation library JEFF-3/A, the decay data and fission yield library, and fusion-related data files from the EFF project. The revisions were motivated by the availability of new measurements, modelling capabilities, or trends from integral experiments. Various pre-release validation efforts are underway, mainly for criticality and shielding of thermal and fast systems. This JEFF-3.1 library is expected to provide improved performances with respect to previous releases for a variety of scientific and industrial applications

State Virtual Libraries

Science.gov (United States)

Pappas, Marjorie L.

2003-01-01

Virtual library? Electronic library? Digital library? Online information network? These all apply to the growing number of Web-based resource collections managed by consortiums of state library entities. Some, like "INFOhio" and "KYVL" ("Kentucky Virtual Library"), have been available for a few years, but others are just starting. Searching for…

Selling library services and skills in Nigeria: the prospect for library ...

African Journals Online (AJOL)

The paper proffered a model for the domestication of entrepreneurial education in library and information science, while it listed skills for LIS graduates such as Independent and self-employment, Reliable information provision, Effective customers' relation, etc as prospects for entrepreneurship education vis-a-vis tools ...

The Motivational Knowledge Management Model: proposal to apply it in the library sector

Directory of Open Access Journals (Sweden)

Daniel López-Fernández

2016-12-01

Full Text Available In professional environments, attention paid to aspects such as supervisory styles, interpersonal relationships and workers eagerness can have a positive impact on employee motivation and, consequently, on their performance and well-being. To achieve this, knowledge management models such as those presented here can be applied. This model generates diagnoses of motivation and recommendations for improvement, both systematically and scientifically. Consequently, it is especially useful for managers and human resource departments. The proposed model can be adapted to different kinds of professional groups, including those in library and documentation services. The suitability, reliability and usefulness of the proposed model have been empirically checked through case studies with 92 students and 166 professionals. The positive results allow us to conclude that the model is effective and useful for assessing and improving motivation.

Consortia for Electronic Library Provision in Belgium

Directory of Open Access Journals (Sweden)

Julien Van Borm

2001-07-01

Full Text Available E-libraries just like the former paper-based libraries will become increasingly essential and indispensable tools in research and education. Library consortia seem to be the way to get e-libraries started all over the world. However, it is unclear yet whether this is going to be a longlasting workable model. The Belgian research libraries follow the international pattern and are rapidly becoming hybrid libraries especially in business, science, applied sciences and biomedicine (the STM disciplines. Still they have large paper bound collections on board and no library is willing to replace these in the near future by a purely electronic collection of journals. The fear of losing the content and thus the „raison d’être“ of the library and the concern for users not yet familiar with e-information sources are the cornerstone for a prudent, yet conservative policy. Increasingly e-information and e-journals are being taken on board. Paper and electronic go side by side in new hybrid libraries partly also due to the market policy set by the publishers in combining paper and electronic in an attempt to keep or improve the annual turnover reached during the past paper period. The transition from paper to electronic occurred in Belgium somewhat later than in other Western European countries. This confirms the position of Belgium often taking up an average position in Western Europe.

Towards annotating the plant epigenome: the Arabidopsis thaliana small RNA locus map.

Science.gov (United States)

Hardcastle, Thomas J; Müller, Sebastian Y; Baulcombe, David C

2018-04-20

Based on 98 public and internal small RNA high throughput sequencing libraries, we mapped small RNAs to the genome of the model organism Arabidopsis thaliana and defined loci based on their expression using an empirical Bayesian approach. The resulting loci were subsequently classified based on their genetic and epigenetic context as well as their expression properties. We present the results of this classification, which broadly conforms to previously reported divisions between transcriptional and post-transcriptional gene silencing small RNAs, and to PolIV and PolV dependencies. However, we are able to demonstrate the existence of further subdivisions in the small RNA population of functional significance. Moreover, we present a framework for similar analyses of small RNA populations in all species.

Construction of a T7 Human Lung Cancer cDNA Library

Directory of Open Access Journals (Sweden)

Wentao YUE

2008-10-01

Full Text Available Background and objective Currently, only a limited numbers of tumor markers for non small lung cancer (NSCLC diagnosis, new biomarker, such as serum autoantibody may improve the early detection of lung cancer. Our objective is construction human lung squamous carcinoma and adenocarcinoma T7 phage display cDNA library from the tissues of NSCLC patients. Methods mRNA was isolated from a pool of total RNA extract from NSCLC tissues obtained from 5 adenocarcinomas and 5 squamous carcinomas, and then mRNA was reverse transcribed into double stranded cDNA. After digestion, the cDNA was inserted into T7Select 10-3 vector. The phage display cDNA library was constructed by package reaction in vitro and plate proliferation. Plaque assay and PCR were used to evaluate the library.Results Two T7 phage display cDNA library were established. Plaque assay show the titer of lung squamas carcinoma library was 1.8×106 pfu, and the adenocarcinoma library was 5×106 pfu. The phage titer of the amplified library were 3.2×1010 pfu/mL and 2.5×1010 pfu/mL. PCR amplification of random plaque show insert ratio were 100% (24/24 in adenocarcinoma library and 95.8% in human lung squamas carcinoma library (23/24. Insert range from 300 bp to 1 500 bp. Conclusion Two phage display cDNA library from NSCLC were constructed.

Research Library

Science.gov (United States)

Los Alamos National Laboratory Research Library Search Site submit Contact Us | Remote Access Standards Theses/Dissertations Research Help Subject Guides Library Training Video Tutorials Alerts Research Library: delivering essential knowledge services for national security sciences since 1947 Los

Library Systems: FY 2013 Public Libraries Survey (Administrative Entity)

Data.gov (United States)

Institute of Museum and Library Services — Find key information on library systems around the United States.These data include imputed values for libraries that did not submit information in the FY 2013 data...

Library Systems: FY 2012 Public Libraries Survey (Administrative Entity)

Data.gov (United States)

Institute of Museum and Library Services — Find key information on library systems around the United States.These data include imputed values for libraries that did not submit information in the FY 2012 data...

A Model for Managing 3D Printing Services in Academic Libraries

Science.gov (United States)

Scalfani, Vincent F.; Sahib, Josh

2013-01-01

The appearance of 3D printers in university libraries opens many opportunities for advancing outreach, teaching, and research programs. The University of Alabama (UA) Libraries recently adopted 3D printing technology and maintains an open access 3D Printing Studio. The Studio consists of a 3D printer, multiple 3D design workstations, and other…

Managing ebook metadata in academic libraries taming the tiger

CERN Document Server

Frederick, Donna E

2016-01-01

Managing ebook Metadata in Academic Libraries: Taming the Tiger tackles the topic of ebooks in academic libraries, a trend that has been welcomed by students, faculty, researchers, and library staff. However, at the same time, the reality of acquiring ebooks, making them discoverable, and managing them presents library staff with many new challenges. Traditional methods of cataloging and managing library resources are no longer relevant where the purchasing of ebooks in packages and demand driven acquisitions are the predominant models for acquiring new content. Most academic libraries have a complex metadata environment wherein multiple systems draw upon the same metadata for different purposes. This complexity makes the need for standards-based interoperable metadata more important than ever. In addition to complexity, the nature of the metadata environment itself typically varies slightly from library to library making it difficult to recommend a single set of practices and procedures which would be releva...

Library Computing

Science.gov (United States)

Library Computing, 1985

1985-01-01

Special supplement to "Library Journal" and "School Library Journal" covers topics of interest to school, public, academic, and special libraries planning for automation: microcomputer use, readings in automation, online searching, databases of microcomputer software, public access to microcomputers, circulation, creating a…

Methods for the preparation of large quantities of complex single-stranded oligonucleotide libraries.

Science.gov (United States)

Murgha, Yusuf E; Rouillard, Jean-Marie; Gulari, Erdogan

2014-01-01

Custom-defined oligonucleotide collections have a broad range of applications in fields of synthetic biology, targeted sequencing, and cytogenetics. Also, they are used to encode information for technologies like RNA interference, protein engineering and DNA-encoded libraries. High-throughput parallel DNA synthesis technologies developed for the manufacture of DNA microarrays can produce libraries of large numbers of different oligonucleotides, but in very limited amounts. Here, we compare three approaches to prepare large quantities of single-stranded oligonucleotide libraries derived from microarray synthesized collections. The first approach, alkaline melting of double-stranded PCR amplified libraries with a biotinylated strand captured on streptavidin coated magnetic beads results in little or no non-biotinylated ssDNA. The second method wherein the phosphorylated strand of PCR amplified libraries is nucleolyticaly hydrolyzed is recommended when small amounts of libraries are needed. The third method combining in vitro transcription of PCR amplified libraries to reverse transcription of the RNA product into single-stranded cDNA is our recommended method to produce large amounts of oligonucleotide libraries. Finally, we propose a method to remove any primer binding sequences introduced during library amplification.

Libraries on the MOVE.

Science.gov (United States)

Edgar, Jim; And Others

1986-01-01

Presents papers from Illinois State Library and Shawnee Library System's "Libraries on the MOVE" conference focusing on how libraries can impact economic/cultural climate of an area. Topics addressed included information services of rural libraries; marketing; rural library development; library law; information access; interagency…

Stability of a neural network model with small-world connections

International Nuclear Information System (INIS)

Li Chunguang; Chen Guanrong

2003-01-01

Small-world networks are highly clustered networks with small distances among the nodes. There are many biological neural networks that present this kind of connection. There are no special weightings in the connections of most existing small-world network models. However, this kind of simply connected model cannot characterize biological neural networks, in which there are different weights in synaptic connections. In this paper, we present a neural network model with weighted small-world connections and further investigate the stability of this model

Critical Features of Fragment Libraries for Protein Structure Prediction.

Science.gov (United States)

Trevizani, Raphael; Custódio, Fábio Lima; Dos Santos, Karina Baptista; Dardenne, Laurent Emmanuel

2017-01-01

The use of fragment libraries is a popular approach among protein structure prediction methods and has proven to substantially improve the quality of predicted structures. However, some vital aspects of a fragment library that influence the accuracy of modeling a native structure remain to be determined. This study investigates some of these features. Particularly, we analyze the effect of using secondary structure prediction guiding fragments selection, different fragments sizes and the effect of structural clustering of fragments within libraries. To have a clearer view of how these factors affect protein structure prediction, we isolated the process of model building by fragment assembly from some common limitations associated with prediction methods, e.g., imprecise energy functions and optimization algorithms, by employing an exact structure-based objective function under a greedy algorithm. Our results indicate that shorter fragments reproduce the native structure more accurately than the longer. Libraries composed of multiple fragment lengths generate even better structures, where longer fragments show to be more useful at the beginning of the simulations. The use of many different fragment sizes shows little improvement when compared to predictions carried out with libraries that comprise only three different fragment sizes. Models obtained from libraries built using only sequence similarity are, on average, better than those built with a secondary structure prediction bias. However, we found that the use of secondary structure prediction allows greater reduction of the search space, which is invaluable for prediction methods. The results of this study can be critical guidelines for the use of fragment libraries in protein structure prediction.

Comparison of Iranian National Medical Library with digital libraries of selected countries.

Science.gov (United States)

Zare-Farashbandi, Firoozeh; Najafi, Nayere Sadat Soleimanzade; Atashpour, Bahare

2014-01-01

The important role of information and communication technologies and their influence on methods of storing, retrieving information in digital libraries, has not only changed the meanings behind classic library activates but has also created great changes in their services. However, it seems that not all digital libraries provide their users with similar services and only some of them are successful in fulfilling their role in digital environment. The Iranian National Medical library is among those that appear to come short compared to other digital libraries around the world. By knowing the different services provided by digital libraries worldwide, one can evaluate the services provided by Iranian National Medical library. The goal of this study is a comparison between Iranian National Medical library and digital libraries of selected countries. This is an applied study and uses descriptive - survey method. The statistical population is the digital libraries around the world which were actively providing library services between October and December 2011 and were selected by using the key word "Digital Library" in Google search engine. The data-gathering tool was direct access to the websites of these digital libraries. The statistical study is descriptive and Excel software was used for data analysis and plotting of the charts. The findings showed that among the 33 digital libraries investigated worldwide, most of them provided Browse (87.87%), Search (84.84%), and Electronic information retrieval (57.57%) services. The "Help" in public services (48/48%) and "Interlibrary Loan" in traditional services (27/27%) had the highest frequency. The Iranian National Medical library provides more digital services compared to other libraries but has less classic and public services and has less than half of possible public services. Other than Iranian National Medical library, among the 33 libraries investigated, the leaders in providing different services are Library of

Rosetta comparative modeling for library design: Engineering alternative inducer specificity in a transcription factor.

Science.gov (United States)

Jha, Ramesh K; Chakraborti, Subhendu; Kern, Theresa L; Fox, David T; Strauss, Charlie E M

2015-07-01

Structure-based rational mutagenesis for engineering protein functionality has been limited by the scarcity and difficulty of obtaining crystal structures of desired proteins. On the other hand, when high-throughput selection is possible, directed evolution-based approaches for gaining protein functionalities have been random and fortuitous with limited rationalization. We combine comparative modeling of dimer structures, ab initio loop reconstruction, and ligand docking to select positions for mutagenesis to create a library focused on the ligand-contacting residues. The rationally reduced library requirement enabled conservative control of the substitutions by oligonucleotide synthesis and bounding its size within practical transformation efficiencies (∼ 10(7) variants). This rational approach was successfully applied on an inducer-binding domain of an Acinetobacter transcription factor (TF), pobR, which shows high specificity for natural effector molecule, 4-hydroxy benzoate (4HB), but no native response to 3,4-dihydroxy benzoate (34DHB). Selection for mutants with high transcriptional induction by 34DHB was carried out at the single-cell level under flow cytometry (via green fluorescent protein expression under the control of pobR promoter). Critically, this selection protocol allows both selection for induction and rejection of constitutively active mutants. In addition to gain-of-function for 34DHB induction, the selected mutants also showed enhanced sensitivity and response for 4HB (native inducer) while no sensitivity was observed for a non-targeted but chemically similar molecule, 2-hydroxy benzoate (2HB). This is unique application of the Rosetta modeling protocols for library design to engineer a TF. Our approach extends applicability of the Rosetta redesign protocol into regimes without a priori precision structural information. © 2015 Wiley Periodicals, Inc.

E-Books in Academic Libraries: Results of a Survey Carried out in Sweden and Lithuania

Science.gov (United States)

Maceviciute, Elena; Wilson, T. D.; Gudinavicius, Arunas; Šuminas, Andrius

2017-01-01

Introduction: This paper reports on a study of e-books issues in academic libraries in two European countries representative of small language markets--Sweden and Lithuania. Method: Questionnaire surveys, using the same instrument, were carried out in Swedish and Lithuanian academic libraries. Analysis: Quantitative analysis was performed using…

Using Cloud Services for Library IT Infrastructure

OpenAIRE

Erik Mitchell

2010-01-01

Cloud computing comes in several different forms and this article documents how service, platform, and infrastructure forms of cloud computing have been used to serve library needs. Following an overview of these uses the article discusses the experience of one library in migrating IT infrastructure to a cloud environment and concludes with a model for assessing cloud computing.

Generation of a Broad-Group HTGR Library for Use with SCALE

International Nuclear Information System (INIS)

Ellis, Ronald James; Lee, Deokjung; Wiarda, Dorothea; Williams, Mark L.; Mertyurek, Ugur

2012-01-01

With current and ongoing interest in high temperature gas reactors (HTGRs), the U.S. Nuclear Regulatory Commission (NRC) anticipates the need for nuclear data libraries appropriate for use in applications for modeling, assessing, and analyzing HTGR reactor physics and operating behavior. The objective of this work was to develop a broad-group library suitable for production analyses with SCALE for HTGR applications. Several interim libraries were generated from SCALE fine-group 238- and 999-group libraries, and the final broad-group library was created from Evaluated Nuclear Data File/B Version ENDF/B-VII Release 0 cross-section evaluations using new ORNL methodologies with AMPX, SCALE, and other codes. Furthermore, intermediate resonance (IR) methods were applied to the HTGR broadgroup library, and lambda factors and f-factors were incorporated into the library s nuclear data files. A new version of the SCALE BONAMI module named BONAMI-IR was developed to process the IR data in the new library and, thus, eliminate the need for the CENTRM/PMC modules for resonance selfshielding. This report documents the development of the HTGR broad-group nuclear data library and the results of test and benchmark calculations using the new library with SCALE. The 81-group library is shown to model HTGR cases with similar accuracy to the SCALE 238-group library but with significantly faster computational times due to the reduced number of energy groups and the use of BONAMI-IR instead of BONAMI/CENTRM/PMC for resonance self-shielding calculations.

Perspectives on Library Public Services from Four Leaders

Science.gov (United States)

Dallis, Diane

2017-01-01

This article explores and examines the state of library services through interviewing a small group of directors, associate deans, and associate university librarians of public services and identifying common themes and insightful views on this area of librarianship. The participants respond to the same set of questions that cover topics including…

academic libraries embrace Web access

Directory of Open Access Journals (Sweden)

1997-01-01

Full Text Available This article presents the lessons learned when six universitiesin the West Midlands, UK worked collaboratively within the eLib (Electronic Libraries Programme. These libraries and learning resource centres spent two years focused on a culture change in the support provided to education, law, and life sciences subject departments. Their efforts resulted in a mediation Model for networked information. The project manager for TAPin reflects upon the importance of attitudes, infrastructure, staff skills, appearances and service practices in the process of change.

DOLIB: Distributed Object Library

Energy Technology Data Exchange (ETDEWEB)

D' Azevedo, E.F.

1994-01-01

This report describes the use and implementation of DOLIB (Distributed Object Library), a library of routines that emulates global or virtual shared memory on Intel multiprocessor systems. Access to a distributed global array is through explicit calls to gather and scatter. Advantages of using DOLIB include: dynamic allocation and freeing of huge (gigabyte) distributed arrays, both C and FORTRAN callable interfaces, and the ability to mix shared-memory and message-passing programming models for ease of use and optimal performance. DOLIB is independent of language and compiler extensions and requires no special operating system support. DOLIB also supports automatic caching of read-only data for high performance. The virtual shared memory support provided in DOLIB is well suited for implementing Lagrangian particle tracking techniques. We have also used DOLIB to create DONIO (Distributed Object Network I/O Library), which obtains over a 10-fold improvement in disk I/O performance on the Intel Paragon.

DOLIB: Distributed Object Library

Energy Technology Data Exchange (ETDEWEB)

D`Azevedo, E.F.; Romine, C.H.

1994-10-01

This report describes the use and implementation of DOLIB (Distributed Object Library), a library of routines that emulates global or virtual shared memory on Intel multiprocessor systems. Access to a distributed global array is through explicit calls to gather and scatter. Advantages of using DOLIB include: dynamic allocation and freeing of huge (gigabyte) distributed arrays, both C and FORTRAN callable interfaces, and the ability to mix shared-memory and message-passing programming models for ease of use and optimal performance. DOLIB is independent of language and compiler extensions and requires no special operating system support. DOLIB also supports automatic caching of read-only data for high performance. The virtual shared memory support provided in DOLIB is well suited for implementing Lagrangian particle tracking techniques. We have also used DOLIB to create DONIO (Distributed Object Network I/O Library), which obtains over a 10-fold improvement in disk I/O performance on the Intel Paragon.

Multiobjective Bak-Sneppen model on a small-world network

International Nuclear Information System (INIS)

Elettreby, M.F.

2005-01-01

Small-world networks (SWN) are relevant to biological systems. We study the dynamics of the Bak-Sneppen (BS) model on small-world network, including the concepts of extremal dynamics, multiobjective optimization and coherent noise. We find that the small-world structure stabilizes the system. Also, it is more realistic to augment the Bak-Sneppen model by these concepts

Multiobjective Bak-Sneppen model on a small-world network

International Nuclear Information System (INIS)

Elettreby, M.

2004-09-01

Small-world networks (SWN) are relevant to biological systems. We study the dynamics of the Bak-Sneppen (BS) model on small-world network, including the concepts of extremal dynamics, multiobjective optimization and coherent noise. We find that the small-world structure stabilizes the system. Also, it is more realistic to augment the Bak-Sneppen model by these concepts. (author)

The USF Libraries Virtual Library Project: A Blueprint for Development.

Science.gov (United States)

Metz-Wiseman, Monica; Silver, Susan; Hanson, Ardis; Johnston, Judy; Grohs, Kim; Neville, Tina; Sanchez, Ed; Gray, Carolyn

This report of the Virtual Library Planning Committee (VLPC) is intending to serve as a blueprint for the University of South Florida (USF) Libraries as it shifts from print to digital formats in its evolution into a "Virtual Library". A comprehensive planning process is essential for the USF Libraries to make optimum use of technology,…

Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort.

Science.gov (United States)

Jeschek, Markus; Gerngross, Daniel; Panke, Sven

2016-03-31

Rational flux design in metabolic engineering approaches remains difficult since important pathway information is frequently not available. Therefore empirical methods are applied that randomly change absolute and relative pathway enzyme levels and subsequently screen for variants with improved performance. However, screening is often limited on the analytical side, generating a strong incentive to construct small but smart libraries. Here we introduce RedLibs (Reduced Libraries), an algorithm that allows for the rational design of smart combinatorial libraries for pathway optimization thereby minimizing the use of experimental resources. We demonstrate the utility of RedLibs for the design of ribosome-binding site libraries by in silico and in vivo screening with fluorescent proteins and perform a simple two-step optimization of the product selectivity in the branched multistep pathway for violacein biosynthesis, indicating a general applicability for the algorithm and the proposed heuristics. We expect that RedLibs will substantially simplify the refactoring of synthetic metabolic pathways.

A microfluidic DNA library preparation platform for next-generation sequencing.

Science.gov (United States)

Kim, Hanyoup; Jebrail, Mais J; Sinha, Anupama; Bent, Zachary W; Solberg, Owen D; Williams, Kelly P; Langevin, Stanley A; Renzi, Ronald F; Van De Vreugde, James L; Meagher, Robert J; Schoeniger, Joseph S; Lane, Todd W; Branda, Steven S; Bartsch, Michael S; Patel, Kamlesh D

2013-01-01

Next-generation sequencing (NGS) is emerging as a powerful tool for elucidating genetic information for a wide range of applications. Unfortunately, the surging popularity of NGS has not yet been accompanied by an improvement in automated techniques for preparing formatted sequencing libraries. To address this challenge, we have developed a prototype microfluidic system for preparing sequencer-ready DNA libraries for analysis by Illumina sequencing. Our system combines droplet-based digital microfluidic (DMF) sample handling with peripheral modules to create a fully-integrated, sample-in library-out platform. In this report, we use our automated system to prepare NGS libraries from samples of human and bacterial genomic DNA. E. coli libraries prepared on-device from 5 ng of total DNA yielded excellent sequence coverage over the entire bacterial genome, with >99% alignment to the reference genome, even genome coverage, and good quality scores. Furthermore, we produced a de novo assembly on a previously unsequenced multi-drug resistant Klebsiella pneumoniae strain BAA-2146 (KpnNDM). The new method described here is fast, robust, scalable, and automated. Our device for library preparation will assist in the integration of NGS technology into a wide variety of laboratories, including small research laboratories and clinical laboratories.

A microfluidic DNA library preparation platform for next-generation sequencing.

Directory of Open Access Journals (Sweden)

Hanyoup Kim

Full Text Available Next-generation sequencing (NGS is emerging as a powerful tool for elucidating genetic information for a wide range of applications. Unfortunately, the surging popularity of NGS has not yet been accompanied by an improvement in automated techniques for preparing formatted sequencing libraries. To address this challenge, we have developed a prototype microfluidic system for preparing sequencer-ready DNA libraries for analysis by Illumina sequencing. Our system combines droplet-based digital microfluidic (DMF sample handling with peripheral modules to create a fully-integrated, sample-in library-out platform. In this report, we use our automated system to prepare NGS libraries from samples of human and bacterial genomic DNA. E. coli libraries prepared on-device from 5 ng of total DNA yielded excellent sequence coverage over the entire bacterial genome, with >99% alignment to the reference genome, even genome coverage, and good quality scores. Furthermore, we produced a de novo assembly on a previously unsequenced multi-drug resistant Klebsiella pneumoniae strain BAA-2146 (KpnNDM. The new method described here is fast, robust, scalable, and automated. Our device for library preparation will assist in the integration of NGS technology into a wide variety of laboratories, including small research laboratories and clinical laboratories.

Model Penerimaan E-Library (Studi pada Mahasiswa Unisbank

Directory of Open Access Journals (Sweden)

Yohanes Suhari

2015-12-01

Full Text Available Berkaitan dengan rumusan masalah pada penelitian ini, maka tujuan penelitian ini adalah untuk menganalisis: (1 Pengaruh karakteristik sistem terhadap kemudahan yang dirasakan; (2 Pengaruh karakteristik sistem terhadap manfaat yang dirasakan; (3 Pengaruh kemudahan yang dirasakan terhadap manfaat yang dirasakan; (4 Pengaruh kemudahan yang dirasakan terhadap perilaku niat; dan (5 Pengaruh manfaat yang dirasakan terhadap perilaku niat. Populasi penelitian ini adalah mahasiswa universitas stikubank yang telah menggunakan e-library. Responden ditentukan dengan cara dicari di kampus yang memenuhi syarat yaitu telah menggunakan e-library. Teknik pengambilan sampel yang digunakan adalah purposive accidental sampling. Penelitian ini menghasilkan kesimpulan sebagai berikut : (1 Karakteristik sistem berpengaruh positif terhadap kemudahan yang dirasakan. (2 Karakteristik sistem tidak berpengaruh terhadap manfaat yang dirasakan. (3 Kemudahan yang dirasakan berpengaruh positif terhadap manfaat yang dirasakan. (4 Kemudahan yang dirasakan tidak berpengaruh terhadap perilaku niat. (5 Manfaat yang dirasakan berpengaruh positif terhadap perilaku niat.

Our Stories Transforming Our Libraries: The York County Library System

Directory of Open Access Journals (Sweden)

Mina Edmondson

2016-11-01

Full Text Available These narratives chronicle the authors’ journeys to collaborate and discover the transformative impact that stories have on library culture and library staff. This study describes a research collaboration between York County Libraries and Penn State York. In Phase I, we collected stories from library staff as the library system was being challenged to reimage public libraries for the future. The major themes and types of organizational stories identified in the initial narrative project were presented during a county-wide all-staff in-service training. The library District Consultant (first author and the Penn State professor (second author then facilitated a workshop designed to lead staff in their exploration of these topics and generate a written record of their storytelling/discussions. This data became the basis for Phase II of the project and allowed the system to strategically assess its evolving culture and identity.

Digital library initiative in an Indian research library: an experience report

International Nuclear Information System (INIS)

Venkadesan, S.; Narayanan, A.

1999-01-01

Libraries all over the world are transiting from the traditional print only era to the electronic era. The migration to an electronic library involves the understanding of several issues and requirements at the planning stage itself. This paper describes the various aspects of building a digital library system. Experience of implementing certain strategies in the IGCAR library is discussed in detail. The components of the digital library and the various access levels are discussed with examples. Finally, samples of the IGCAR library web site and the Newsletter web site are shown. (author)

Students lead the library the importance of student contributions to the academic library

CERN Document Server

Arnold-Garza, Sara

2017-01-01

In six parts-Students as Employees, Students as Curators, Students as Ambassadors, the Library as Client, Student Groups as Library Leaders, and Students as Library Designers-Students Lead the Library provides case studies of programs and initiatives that seek student input, assistance, and leadership in the academic library. Through the library, students can develop leadership skills, cultivate high levels of engagement, and offer peer learning opportunities. Through the students, libraries can create participatory design processes, enhancement and transformation of the library's core functions, and expressed library value for stakeholders.

Library service delivery, information literacy knowledge: a modelling ...

African Journals Online (AJOL)

Knowledge preservation, access to information and dissemination has rapidly changed the way people seek and use information. The study concluded that the application of IT will encourage self sufficiency in food production, good health and rapid development among the citizenry. Keywords: Library service delivery, ...

Discussion on AI Technology in Information Library Design

OpenAIRE

日比野, 省三; Shozo, HIBINO; 中京大学社会学部

1987-01-01

This paper deals with the discussion on the importance of AI (Artificial Intelligence) Technology in planning and designing a library information system in the near future. First of all, the history of Library and Information Science is reviewed and it is identified that the key technology in the future library will be AI as a mega-trend. After reviewing the concepts of AI technology, a model of a Knowledge-Base system is discussed as a case study, using micro-PROLOG.

The Medical Library Association Benchmarking Network: development and implementation*

Science.gov (United States)

Dudden, Rosalind Farnam; Corcoran, Kate; Kaplan, Janice; Magouirk, Jeff; Rand, Debra C.; Smith, Bernie Todd

2006-01-01

Objective: This article explores the development and implementation of the Medical Library Association (MLA) Benchmarking Network from the initial idea and test survey, to the implementation of a national survey in 2002, to the establishment of a continuing program in 2004. Started as a program for hospital libraries, it has expanded to include other nonacademic health sciences libraries. Methods: The activities and timelines of MLA's Benchmarking Network task forces and editorial board from 1998 to 2004 are described. Results: The Benchmarking Network task forces successfully developed an extensive questionnaire with parameters of size and measures of library activity and published a report of the data collected by September 2002. The data were available to all MLA members in the form of aggregate tables. Utilization of Web-based technologies proved feasible for data intake and interactive display. A companion article analyzes and presents some of the data. MLA has continued to develop the Benchmarking Network with the completion of a second survey in 2004. Conclusions: The Benchmarking Network has provided many small libraries with comparative data to present to their administrators. It is a challenge for the future to convince all MLA members to participate in this valuable program. PMID:16636702

On various metrics used for validation of predictive QSAR models with applications in virtual screening and focused library design.

Science.gov (United States)

Roy, Kunal; Mitra, Indrani

2011-07-01

Quantitative structure-activity relationships (QSARs) have important applications in drug discovery research, environmental fate modeling, property prediction, etc. Validation has been recognized as a very important step for QSAR model development. As one of the important objectives of QSAR modeling is to predict activity/property/toxicity of new chemicals falling within the domain of applicability of the developed models and QSARs are being used for regulatory decisions, checking reliability of the models and confidence of their predictions is a very important aspect, which can be judged during the validation process. One prime application of a statistically significant QSAR model is virtual screening for molecules with improved potency based on the pharmacophoric features and the descriptors appearing in the QSAR model. Validated QSAR models may also be utilized for design of focused libraries which may be subsequently screened for the selection of hits. The present review focuses on various metrics used for validation of predictive QSAR models together with an overview of the application of QSAR models in the fields of virtual screening and focused library design for diverse series of compounds with citation of some recent examples.

Libraries as 'everyday' settings: the Glasgow MCISS project.

Science.gov (United States)

Whitelaw, Sandy; Coburn, Jonathan; Lacey, Marion; McKee, Martin J; Hill, Carol

2017-10-01

A settings-based approach is now well-established in health promotion, initially undertaken in conventional places like schools and workplaces, but more recently being expressed in a wider range of what Torp et al. call 'everyday' settings. In this context, libraries have emerged as another potential setting whose ubiquity and accessibility suggests that they may be particularly effective in addressing health inequalities. Drawing on a case study-the Glasgow Macmillan Cancer Information and Support Services Library project-this paper reports on the potential for seeing 'libraries as settings' and in the context of a set of associated theoretical resources, specifically scrutinizes the nature of initiative implementation. Data were drawn from multiple sources: semi-structured interviews and focus groups with strategic partners and stakeholders, operational staff, project volunteers, service users and members of the general public. Qualitative data were complemented by quantitative insights from surveys with members of the partnership, libraries staff and volunteers. Despite some concerns associated with potentially hostile cultural and financial contexts that might threaten longer term sustainability, insights suggested that in pragmatic terms, the project was attracting sizable 'footfall' and successfully addressing a range of needs. Additionally, the formal implementation processes associated with project implementation were considered to have been highly successful in embedding the model into the library culture. In summary, there is evidence that libraries have the potential to be considered as supportive settings and could act as a model for an emergent vision of what libraries do. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

E-books in academic libraries

CERN Document Server

Mincic-Obradovic, Ksenija

2010-01-01

Written from the perspective of a librarian, this book offers a comprehensive overview of the impact of e-books on academic libraries. The author discusses advantages to both researchers and librarians and provides current examples of innovative uses of e-books in academic contexts. This book reviews the current situation in e-book publishing, and describes problems in managing e-books in libraries caused by the variety of purchase models and varying formats available, and the lack of standardisation. It discusses solutions for providing access and maintaining bibliographic control, looks at v

Impact of whole-building hygrothermal modelling on the assessment of indoor climate in a library building

Energy Technology Data Exchange (ETDEWEB)

Steeman, M.; Janssens, A. [Ghent University, Department of Architecture and Urban Planning, Jozef Plateaustraat 22, B-9000 Gent (Belgium); De Paepe, M. [Ghent University, Department of Flow, Heat and Combustion Mechanics, Sint-Pietersnieuwstraat 41, B-9000 Gent (Belgium)

2010-07-15

This paper focuses on the importance of accurately modelling the hygrothermal interaction between the building and its hygroscopic content for the assessment of the indoor climate. Libraries contain a large amount of stored books which require a stable relative humidity to guarantee their preservation. On the other hand, visitors and staff must be comfortable with the indoor climate. The indoor climate of a new library building is evaluated by means of measurements and simulations. Complaints of the staff are confirmed by measured data during the winter and summer of 2007-2008. For the evaluation of the indoor climate, a building simulation model is used in which the porous books are either described by a HAM model or by a simplified isothermal model. Calculations demonstrate that the HAM model predicts a more stable indoor climate regarding both temperature and relative humidity variations in comparison to the estimations by the simplified model. This is attributed to the ability of the HAM model to account for the effect of temperature variations on moisture storage. Moreover, by applying the HAM model, a good agreement with the measured indoor climate is found. As expected, a larger exposed book surface ameliorates the indoor climate because a more stable indoor relative humidity is obtained. Finally, the building simulation model is used to improve the indoor climate with respect to the preservation of valuable books. Results demonstrate that more stringent interventions on the air handling unit are expected when a simplified approach is used to model the hygroscopic books. (author)

Evaluation of the quality of the college library websites in Iranian medical Universities based on the Stover model.

Science.gov (United States)

Nasajpour, Mohammad Reza; Ashrafi-Rizi, Hasan; Soleymani, Mohammad Reza; Shahrzadi, Leila; Hassanzadeh, Akbar

2014-01-01

Today, the websites of college and university libraries play an important role in providing the necessary services for clients. These websites not only allow the users to access different collections of library resources, but also provide them with the necessary guidance in order to use the information. The goal of this study is the quality evaluation of the college library websites in Iranian Medical Universities based on the Stover model. This study uses an analytical survey method and is an applied study. The data gathering tool is the standard checklist provided by Stover, which was modified by the researchers for this study. The statistical population is the college library websites of the Iranian Medical Universities (146 websites) and census method was used for investigation. The data gathering method was a direct access to each website and filling of the checklist was based on the researchers' observations. Descriptive and analytical statistics (Analysis of Variance (ANOVA)) were used for data analysis with the help of the SPSS software. The findings showed that in the dimension of the quality of contents, the highest average belonged to type one universities (46.2%) and the lowest average belonged to type three universities (24.8%). In the search and research capabilities, the highest average belonged to type one universities (48.2%) and the lowest average belonged to type three universities. In the dimension of facilities provided for the users, type one universities again had the highest average (37.2%), while type three universities had the lowest average (15%). In general the library websites of type one universities had the highest quality (44.2%), while type three universities had the lowest quality (21.1%). Also the library websites of the College of Rehabilitation and the College of Paramedics, of the Shiraz University of Medical Science, had the highest quality scores. The results showed that there was a meaningful difference between the quality

Calculation and analysis of the source term of the reactor core based on different data libraries

International Nuclear Information System (INIS)

Chen Haiying; Zhang Chunming; Wang Shaowei; Lan Bing; Liu Qiaofeng; Han Jingru

2014-01-01

The nuclear fuel in reactor core produces large amount of radioactive nuclides in the fission process. ORIGEN-S can calculate the accumulation and decay of radioactive nuclides in the core by using various forms of data libraries, including card-image library, binary library and ORIGEN-S cross section library generated by ARP through interpolation method. In this paper, the information of each data library was described, and the reactor core inventory was calculated by using Card-image library and ARP library. The radioactivity concentration of typical nuclides with the change of fuel burnup was analyzed. The results showed that the influence of data libraries on the calculation of nuclide radioactivity was various. Compared to Card-image library, the radioactivity of a small part of nuclides calculated by ARP library were larger and the radioactivity of "1"3"4Cs, "1"3"6Cs were calculated smaller by about 15%. For some typical nuclides, with the deepening of fuel burnup, the difference of nuclide radioactivity calculated by the two libraries increased. However, the changes of the ratio of nuclide radioactivity were different. (authors)

Libraries and Learning

Science.gov (United States)

Rainie, Lee

2016-01-01

The majority of Americans think local libraries serve the educational needs of their communities and families pretty well and library users often outpace others in learning activities. But many do not know about key education services libraries provide. This report provides statistics on library usage and presents key education services provided…

Evaluating Public Libraries Using Standard Scores: The Library Quotient.

Science.gov (United States)

O'Connor, Daniel O.

1982-01-01

Describes a method for assessing the performance of public libraries using a standardized scoring system and provides an analysis of public library data from New Jersey as an example. Library standards and the derivation of measurement ratios are also discussed. A 33-item bibliography and three data tables are included. (JL)

The impact of computerisation of library operations on library ...

African Journals Online (AJOL)

The use of computer-based systems in libraries and information units is now a vogue. The era of manual system in library operations is on its way to extinction. Recent developments in information world tend towards a globalized information communication technology (ICT). The library as a dynamic institution cannot afford ...

Library Systems: FY 2014 Public Libraries Survey (Administrative Entity Data)

Data.gov (United States)

Institute of Museum and Library Services — Find key information on library systems around the United States.These data include imputed values for libraries that did not submit information in the FY 2014 data...

ALTA: A BRDF analysis library

OpenAIRE

Belcour , Laurent; Barla , Pascal; Pacanowski , Romain

2014-01-01

International audience; In this document, we introduce ALTA, a cross platform generic open-source library for Bidirectional Reflectance Distribution Function (BRDF) analysis. Among others, ALTA permits to estimate BRDF models parameters from measured data, to perform statistical analysis and also to export BRDF data models in a wide variety of formats.

Fusion of Library, Archive, Museum, Publisher (LAMP: the NTNU Library Experience

Directory of Open Access Journals (Sweden)

Ke, Hao-Ren

2016-06-01

Full Text Available The convergence of libraries, archives, and museums (LAMs has garnered attention in recent years. Extending the tendency further, National Taiwan Normal University (NTNU fuses the library, archive, museum, and publisher (LAMP functionality together in its library. This article elaborates on the LAMP practices of the NTNU Library, which indicates that without creating new units in a university, its library can play a good role of curating invaluable university assets.

The Homeless in the Public Library: Implications for Access to Libraries.

Science.gov (United States)

Simmons, Randall C.

1985-01-01

Discussion of the homeless in American public libraries focuses on harmless individuals who may be considered nuisance by library staff/patrons. Highlights include literature about problem library patrons, national problem, social issues, major themes (offense to others and library staff, balancing rights, and elitism), and implications for…

The effect of call libraries and acoustic filters on the identification of bat echolocation

Science.gov (United States)

Clement, Matthew; Murray, Kevin L; Solick, Donald I; Gruver, Jeffrey C

2014-01-01

Quantitative methods for species identification are commonly used in acoustic surveys for animals. While various identification models have been studied extensively, there has been little study of methods for selecting calls prior to modeling or methods for validating results after modeling. We obtained two call libraries with a combined 1556 pulse sequences from 11 North American bat species. We used four acoustic filters to automatically select and quantify bat calls from the combined library. For each filter, we trained a species identification model (a quadratic discriminant function analysis) and compared the classification ability of the models. In a separate analysis, we trained a classification model using just one call library. We then compared a conventional model assessment that used the training library against an alternative approach that used the second library. We found that filters differed in the share of known pulse sequences that were selected (68 to 96%), the share of non-bat noises that were excluded (37 to 100%), their measurement of various pulse parameters, and their overall correct classification rate (41% to 85%). Although the top two filters did not differ significantly in overall correct classification rate (85% and 83%), rates differed significantly for some bat species. In our assessment of call libraries, overall correct classification rates were significantly lower (15% to 23% lower) when tested on the second call library instead of the training library. Well-designed filters obviated the need for subjective and time-consuming manual selection of pulses. Accordingly, researchers should carefully design and test filters and include adequate descriptions in publications. Our results also indicate that it may not be possible to extend inferences about model accuracy beyond the training library. If so, the accuracy of acoustic-only surveys may be lower than commonly reported, which could affect ecological understanding or management

Evaluation of library preparation methods for Illumina next generation sequencing of small amounts of DNA from foodborne parasites.

Science.gov (United States)

Nascimento, Fernanda S; Wei-Pridgeon, Yuping; Arrowood, Michael J; Moss, Delynn; da Silva, Alexandre J; Talundzic, Eldin; Qvarnstrom, Yvonne

2016-11-01

Illumina library preparation methods for ultra-low input amounts were compared using genomic DNA from two foodborne parasites (Angiostrongylus cantonensis and Cyclospora cayetanensis) as examples. The Ovation Ultralow method resulted in libraries with the highest concentration and produced quality sequencing data, even when the input DNA was in the picogram range. Published by Elsevier B.V.

What in the World Is a State Library? Issues in State Library Management.

Science.gov (United States)

Weaver, Barbara

1990-01-01

Provides an overview of the various roles of state libraries and discusses several issues of concern to all state libraries: the role of the library within state government; resources sharing; school library development; public library development; automation consulting; continuing education for library professionals; and the leadership role of…

Libraries in society

DEFF Research Database (Denmark)

Kristiansson, Michael; Skouvig, Laura Henriette Christine

2008-01-01

The purpose of the paper is to investigate the phenomenon of openness in relation to library development. The term openness is presented and related to library development from historical and theoretical perspectives. The paper elaborates on the differences over time on to how openness has been...... understood in a library setting. Historically, openness in form of the open shelves played a crucial role in developing the modern public library. The paper examines this openness-centred library policy as adopted by Danish public libraries in the beginning of the 20th century by applying the theories...... by Michel Foucault on discourse and power to the introduction of open shelves. Furthermore, the paper discusses current challenges facing the modern public library in coping with openness issues that follow from changes in society and advances in technology. These influences and developments are not least...

From Libraries to ‘Libratories’

Directory of Open Access Journals (Sweden)

Leo Waaijers

2006-04-01

Full Text Available While the eighties of the last century were a time of local automation for libraries and the nineties the decade in which libraries embraced the internet and the WWW, now is the age in which the big search engines and institutional repositories are gaining a firm footing. This heralds a new era in both the evolution of scholarly communication and its agencies themselves, i.e. the libraries. Until now libraries and publishers have developed a digital variant of existing processes and products, i.e. catalogues posted on the Web, scanned copies of articles, e-mail notification about acquisitions or expired lending periods, or traditional journals in a digital jacket. However, the new OAI repositories and services based upon them have given rise to entirely new processes and products, libraries transforming themselves into partners in setting up virtual learning environments, building an institution’s digital showcase, maintaining academics’ personal websites, designing refereed portals and – further into the future – taking part in organising virtual research environments or collaboratories. Libraries are set to metamorphose into ‘libratories’, an imaginary word to express their combined functions of library, repository and collaboratory. In such environments scholarly communication will be liberated from its current copyright bridle while its coverage will be both broader - including primary data, audiovisuals and dynamic models - and deeper, with cross-disciplinary analyses of methodologies and applications of instruments. Universities will make it compulsory to store in their institutional repositories the results of research conducted within their walls for purposes of academic reporting, review committees, and other modes of clarification and explanation. Big search engines will provide access to this profusion of information and organise its mass customisation.

Library fingerprints: a novel approach to the screening of virtual libraries.

Science.gov (United States)

Klon, Anthony E; Diller, David J

2007-01-01

We propose a novel method to prioritize libraries for combinatorial synthesis and high-throughput screening that assesses the viability of a particular library on the basis of the aggregate physical-chemical properties of the compounds using a naïve Bayesian classifier. This approach prioritizes collections of related compounds according to the aggregate values of their physical-chemical parameters in contrast to single-compound screening. The method is also shown to be useful in screening existing noncombinatorial libraries when the compounds in these libraries have been previously clustered according to their molecular graphs. We show that the method used here is comparable or superior to the single-compound virtual screening of combinatorial libraries and noncombinatorial libraries and is superior to the pairwise Tanimoto similarity searching of a collection of combinatorial libraries.

Universal Library for Building Radar Operator Interface

Directory of Open Access Journals (Sweden)

A. A. Karankevich

2014-01-01

Full Text Available The article contains the results of the development of a software library, used for building software interfaces for radars being developed in BMSTU Radioelectronic Technics Scientific and Research Institute. The library is a software application library written in C++ using Qt and OpenGL libraries.The article describes the requirements, that the library is supposed to meet, in particular — cross-platform capabilities and versatility of the solution. The data types, that library uses, are described. The description of theinterface elements developed is shown, and some pictures of their operation are given.The article shows the main interface elements used. They are: «Matrix» that shows twodimensional data, «Waterfall», that is used for time scanning of the parameter specified, and «Plan Position Indicator» that shows circular scan from surveillance radar without geometric distortions.The part «Library implementation» shows the example of radiolocation station interface, that was based on this library, used in the working model of ultrashortpulse radar. Some results of the operation of this interface are also shown. The experiment shows the system working with two people in the field. As people start to move, the system becomes capable of distinguishing moving targets and stationary surface. The article shows the system operation the same way as the system operator can see it through his interface.The conclusion contains brief results of the development, the sphere of application of the software, and the prospects of the further development of the library.

E-Library and Traditonal Library Resources Usage: A Comparative ...

African Journals Online (AJOL)

A comparative usage of e-library and traditional resources in Nigerian libraries was examined in this study. A descriptive survey method was adopted and a purposive sampling technique was used to select the sample and the process produced 125 academic, research, and public libraries in Nigeria. A total of 116 cases ...

Mining olive genome through library sequencing and bioinformatics ...

African Journals Online (AJOL)

As one of the initial steps of olive (Olea europaea L.) genome analysis, a small insert genomic DNA library was constructed (digesting olive genomic DNA with SmaI and cloning the digestion products into pUC19 vector) and randomly picked 83 colonies were sequenced. Analysis of the insert sequences revealed 12 clones ...

Rambrain - a library for virtually extending physical memory

Directory of Open Access Journals (Sweden)

M. Imgrund

2017-01-01

Full Text Available We introduce Rambrain, a user space C++ library that manages memory consumption of data-intense applications. Using Rambrain, one can overcommit memory beyond the size of physical memory present in the system. While there exist other more advanced techniques to solve this problem, Rambrain focuses on saving development time by providing a fast, general and easy-to-use solution. Rambrain takes care of temporarily swapping out data to disk and can handle multiples of the physical memory size present. Rambrain is thread-safe, OpenMP and MPI compatible and supports asynchronous I/O. The library is designed to require minimal changes to existing programs and pose only a small overhead.

A divide-and-conquer algorithm for large-scale de novo transcriptome assembly through combining small assemblies from existing algorithms.

Science.gov (United States)

Sze, Sing-Hoi; Parrott, Jonathan J; Tarone, Aaron M

2017-12-06

While the continued development of high-throughput sequencing has facilitated studies of entire transcriptomes in non-model organisms, the incorporation of an increasing amount of RNA-Seq libraries has made de novo transcriptome assembly difficult. Although algorithms that can assemble a large amount of RNA-Seq data are available, they are generally very memory-intensive and can only be used to construct small assemblies. We develop a divide-and-conquer strategy that allows these algorithms to be utilized, by subdividing a large RNA-Seq data set into small libraries. Each individual library is assembled independently by an existing algorithm, and a merging algorithm is developed to combine these assemblies by picking a subset of high quality transcripts to form a large transcriptome. When compared to existing algorithms that return a single assembly directly, this strategy achieves comparable or increased accuracy as memory-efficient algorithms that can be used to process a large amount of RNA-Seq data, and comparable or decreased accuracy as memory-intensive algorithms that can only be used to construct small assemblies. Our divide-and-conquer strategy allows memory-intensive de novo transcriptome assembly algorithms to be utilized to construct large assemblies.

Building a Library App Portfolio with Redis and Django

Directory of Open Access Journals (Sweden)

Jeremy Nelson

2013-01-01

Full Text Available The Tutt Library at Colorado College is developing a portfolio of library applications for use by patrons and library staff. Developed under an iterative and incremental agile model, these single-use HTML5 applications target multiple devices while using Bootstrap and Django to deliver fast and responsive interfaces to underlying FRBR datastores running on Redis, an advanced NoSQL database server. Two types are delineated: applications for access and discovery, which are available to everyone; and productivity applications, which are primarily for library staff to administer and manage the FRBR-RDA records. The access portfolio includes Book Search, Article Search, Call Number, and Library Hours applications. The productivity side includes an Orders App and a MARC Batch application for ingesting MARC records as FRBR entities using RDA Core attributes. When a critical threshold is reached, the Tutt Library intends to replace its legacy ILS with this library application portfolio.

External Variables as Antecedents of Users Perception in Virtual Library Usage

Directory of Open Access Journals (Sweden)

Olusola I. Akinbobola

2016-05-01

Full Text Available Several studies extended the Technology Acceptance Model (TAM by examining the antecedents of perceived usefulness and perceived ease of use; the present study looks at demographic aspect of external variables in virtual library use among undergraduate students. The purpose of this study is to identify the demographic factors sex, level of study, cumulative grade point average, and computer knowledge that act as external factors that are antecedents of perceived usefulness and perceived ease of use. The university management makes a large investment in the provision of a virtual library; investigation of the virtual library acceptance by students is important. TAM and theory of reasoned action (TRA are utilised to theoretically test a model for the extension and to predict virtual library acceptance and usage. In a survey study, data was collected by using a structured questionnaire given to 394 randomly selected participants in a private university. Data were analysed by Pearson product moment correlation, multiple and hierarchical regression. The result of the study is consistent with TAM factors examined for explaining virtual library usage. The extension model accounts for 2.5% variance in perceived usefulness, 2.1% in perceived ease of use, 11.7% - 15.2% on intention to use and 7.2% on actual use of virtual library. Implications of the findings of the study on user’s virtual library training are discussed.

The Development of National Library Functions in the British Museum Library and the Library of Congress.

Science.gov (United States)

Stewart, Richard Addison

The histories of two national libraries, the British Museum Library and the Library of Congress, are examined with respect to the development of each of three functions: (1) the acquisition and maintenance of a comprehensive collection of the country's publications, usually by copyright deposit; (2) the maintenance of basic research collections in…

Use of library statistics to support library and advisory services and ...

African Journals Online (AJOL)

Statistical information is a vital tool for management and development of organizations. Keeping statistics of activities is basic to the survival and progress of a library and enables the library to measure its performance periodically. The National Library of Nigeria (NLN) places high premium on the library statistics that it ...

Is Your Academic Library Pinning? Academic Libraries and Pinterest

Science.gov (United States)

Thornton, Elaine

2012-01-01

Academic libraries are flocking to online social networking sites in an effort to meet users where they are. Pinterest is the latest of these rapidly growing online social networking tools. The author of this article reports results from a survey on academic libraries' presence on Pinterest. The survey found most academic library pinboards are in…

Library/vendor relationships

CERN Document Server

Brooks, Sam

2014-01-01

A view of the mutual dependence between libraries and vendorsAs technology advances, libraries are forced to reach beyond their own resources to find effective ways to maintain accuracy and superior service levels. Vendors provide databases and integrated library systems that perform those functions for profit. Library/Vendor Relationships examines the increasing cooperation in which libraries find they must participate in, and vice versa, with the vendors that provide system infrastructure and software. Expert contributors provide insights from all sides of this unique collaboration, offering

Personalized Boutique Service: Critical to Academic Library Success?

Science.gov (United States)

Tilley, Elizabeth

2013-01-01

An academic library that focuses on delivering a personalized service is examined within the context of the boutique library model. It is suggested that a critical success factor in adopting a personalized, boutique-style service is acquiring knowledge and insight of our users. This, together with appropriate evaluation, will assist with providing…

Algebraic approach to small-world network models

Science.gov (United States)

Rudolph-Lilith, Michelle; Muller, Lyle E.

2014-01-01

We introduce an analytic model for directed Watts-Strogatz small-world graphs and deduce an algebraic expression of its defining adjacency matrix. The latter is then used to calculate the small-world digraph's asymmetry index and clustering coefficient in an analytically exact fashion, valid nonasymptotically for all graph sizes. The proposed approach is general and can be applied to all algebraically well-defined graph-theoretical measures, thus allowing for an analytical investigation of finite-size small-world graphs.

THERMLIB, Generator and Edit of Program THERMOS-OTA Library. THERLIB, Library Generated for THERMOS from FACEL Library

International Nuclear Information System (INIS)

Rastas, A.

1985-01-01

1 - Description of problem or function: THERMLIB is a code that generates, revises and expands the input data library to the lattice cell code THERMOS-OTA. It can be used to: - create an entirely new library; - modify the data of library materials, remove materials, add materials; - list the library. 2 - Restrictions on the complexity of the problem: Max. of 30 materials may be modified or removed. Max. of 30 new materials may be created. Max. of 50 velocity groups

Initial draft of CSE-UCLA evaluation model based on weighted product in order to optimize digital library services in computer college in Bali

Science.gov (United States)

Divayana, D. G. H.; Adiarta, A.; Abadi, I. B. G. S.

2018-01-01

The aim of this research was to create initial design of CSE-UCLA evaluation model modified with Weighted Product in evaluating digital library service at Computer College in Bali. The method used in this research was developmental research method and developed by Borg and Gall model design. The results obtained from the research that conducted earlier this month was a rough sketch of Weighted Product based CSE-UCLA evaluation model that the design had been able to provide a general overview of the stages of weighted product based CSE-UCLA evaluation model used in order to optimize the digital library services at the Computer Colleges in Bali.

Academic library use of ebooks

CERN Document Server

2014-01-01

This 165-page international study looks closely at how academic libraries are using eBooks. It helps librarians to answer questions such as: how fast is eBook spending growing? Which eBook purchasing models are growing fastest? Subscription models that allow unlimited access” pay per view models? Outright ownership? Other models? What percentage of eBook purchases are through consortia? What percentage direct from publishers? What percentage through aggregators?

How to Use Benchmark and Cross-section Studies to Improve Data Libraries and Models

Science.gov (United States)

Wagner, V.; Suchopár, M.; Vrzalová, J.; Chudoba, P.; Svoboda, O.; Tichý, P.; Krása, A.; Majerle, M.; Kugler, A.; Adam, J.; Baldin, A.; Furman, W.; Kadykov, M.; Solnyshkin, A.; Tsoupko-Sitnikov, S.; Tyutyunikov, S.; Vladimirovna, N.; Závorka, L.

2016-06-01

Improvements of the Monte Carlo transport codes and cross-section libraries are very important steps towards usage of the accelerator-driven transmutation systems. We have conducted a lot of benchmark experiments with different set-ups consisting of lead, natural uranium and moderator irradiated by relativistic protons and deuterons within framework of the collaboration “Energy and Transmutation of Radioactive Waste”. Unfortunately, the knowledge of the total or partial cross-sections of important reactions is insufficient. Due to this reason we have started extensive studies of different reaction cross-sections. We measure cross-sections of important neutron reactions by means of the quasi-monoenergetic neutron sources based on the cyclotrons at Nuclear Physics Institute in Řež and at The Svedberg Laboratory in Uppsala. Measurements of partial cross-sections of relativistic deuteron reactions were the second direction of our studies. The new results obtained during last years will be shown. Possible use of these data for improvement of libraries, models and benchmark studies will be discussed.

Teleporting the library?

DEFF Research Database (Denmark)

Heilesen, Simon

2009-01-01

In 2007, six Danish public libraries established a virtual library, Info Island DK, in Second Life. This article discusses the library project in terms of design. The design processes include the planning and implementation of the virtual library structure and its equipment, as well...... as the organizing and carrying out of activities in the virtual setting. It will be argued that, to a large extent, conventions have determined design and use of the virtual library, and also that design has had an impact on the attitudes and understanding of the participants....

Comprehensive Assessment of Models and Events based on Library tools (CAMEL)

Science.gov (United States)

Rastaetter, L.; Boblitt, J. M.; DeZeeuw, D.; Mays, M. L.; Kuznetsova, M. M.; Wiegand, C.

2017-12-01

At the Community Coordinated Modeling Center (CCMC), the assessment of modeling skill using a library of model-data comparison metrics is taken to the next level by fully integrating the ability to request a series of runs with the same model parameters for a list of events. The CAMEL framework initiates and runs a series of selected, pre-defined simulation settings for participating models (e.g., WSA-ENLIL, SWMF-SC+IH for the heliosphere, SWMF-GM, OpenGGCM, LFM, GUMICS for the magnetosphere) and performs post-processing using existing tools for a host of different output parameters. The framework compares the resulting time series data with respective observational data and computes a suite of metrics such as Prediction Efficiency, Root Mean Square Error, Probability of Detection, Probability of False Detection, Heidke Skill Score for each model-data pair. The system then plots scores by event and aggregated over all events for all participating models and run settings. We are building on past experiences with model-data comparisons of magnetosphere and ionosphere model outputs in GEM2008, GEM-CEDAR CETI2010 and Operational Space Weather Model challenges (2010-2013). We can apply the framework also to solar-heliosphere as well as radiation belt models. The CAMEL framework takes advantage of model simulations described with Space Physics Archive Search and Extract (SPASE) metadata and a database backend design developed for a next-generation Run-on-Request system at the CCMC.

Public Libraries in Bangladesh.

Science.gov (United States)

Khan, M. H.

1984-01-01

Overview of library movement in Bangladesh highlights British (1851-1947) and Pakistan periods (1947-1971), separation of Bangladesh from Pakistan, libraries in development plans (1951-1970), three important public libraries, development of national library, book resources, a library network plan, legislation, finance, leadership, library…

High-throughput screening of small molecule libraries using SAMDI mass spectrometry.

Science.gov (United States)

Gurard-Levin, Zachary A; Scholle, Michael D; Eisenberg, Adam H; Mrksich, Milan

2011-07-11

High-throughput screening is a common strategy used to identify compounds that modulate biochemical activities, but many approaches depend on cumbersome fluorescent reporters or antibodies and often produce false-positive hits. The development of "label-free" assays addresses many of these limitations, but current approaches still lack the throughput needed for applications in drug discovery. This paper describes a high-throughput, label-free assay that combines self-assembled monolayers with mass spectrometry, in a technique called SAMDI, as a tool for screening libraries of 100,000 compounds in one day. This method is fast, has high discrimination, and is amenable to a broad range of chemical and biological applications.

The library catalogue as a retrieval tool in academic libraries: a case ...

African Journals Online (AJOL)

The library catalogue as a retrieval tool in academic libraries: a case study of federal university of technology Owerri library. ... Information Technologist (The) ... be emphasized and made compulsory for a ll library users and strengthening the ...

Building a better fragment library for de novo protein structure prediction.

Directory of Open Access Journals (Sweden)

Saulo H P de Oliveira

Full Text Available Fragment-based approaches are the current standard for de novo protein structure prediction. These approaches rely on accurate and reliable fragment libraries to generate good structural models. In this work, we describe a novel method for structure fragment library generation and its application in fragment-based de novo protein structure prediction. The importance of correct testing procedures in assessing the quality of fragment libraries is demonstrated. In particular, the exclusion of homologs to the target from the libraries to correctly simulate a de novo protein structure prediction scenario, something which surprisingly is not always done. We demonstrate that fragments presenting different predominant predicted secondary structures should be treated differently during the fragment library generation step and that exhaustive and random search strategies should both be used. This information was used to develop a novel method, Flib. On a validation set of 41 structurally diverse proteins, Flib libraries presents both a higher precision and coverage than two of the state-of-the-art methods, NNMake and HHFrag. Flib also achieves better precision and coverage on the set of 275 protein domains used in the two previous experiments of the the Critical Assessment of Structure Prediction (CASP9 and CASP10. We compared Flib libraries against NNMake libraries in a structure prediction context. Of the 13 cases in which a correct answer was generated, Flib models were more accurate than NNMake models for 10. "Flib is available for download at: http://www.stats.ox.ac.uk/research/proteins/resources".

Building a Better Fragment Library for De Novo Protein Structure Prediction

Science.gov (United States)

de Oliveira, Saulo H. P.; Shi, Jiye; Deane, Charlotte M.

2015-01-01

Fragment-based approaches are the current standard for de novo protein structure prediction. These approaches rely on accurate and reliable fragment libraries to generate good structural models. In this work, we describe a novel method for structure fragment library generation and its application in fragment-based de novo protein structure prediction. The importance of correct testing procedures in assessing the quality of fragment libraries is demonstrated. In particular, the exclusion of homologs to the target from the libraries to correctly simulate a de novo protein structure prediction scenario, something which surprisingly is not always done. We demonstrate that fragments presenting different predominant predicted secondary structures should be treated differently during the fragment library generation step and that exhaustive and random search strategies should both be used. This information was used to develop a novel method, Flib. On a validation set of 41 structurally diverse proteins, Flib libraries presents both a higher precision and coverage than two of the state-of-the-art methods, NNMake and HHFrag. Flib also achieves better precision and coverage on the set of 275 protein domains used in the two previous experiments of the the Critical Assessment of Structure Prediction (CASP9 and CASP10). We compared Flib libraries against NNMake libraries in a structure prediction context. Of the 13 cases in which a correct answer was generated, Flib models were more accurate than NNMake models for 10. “Flib is available for download at: http://www.stats.ox.ac.uk/research/proteins/resources”. PMID:25901595

New data libraries and physics data management tools

International Nuclear Information System (INIS)

Han, M; Kim, C H; Seo, H; Pia, M G; Saracco, P; Augelli, M; Hauf, S; Kuster, M; Moneta, L; Quintieri, L

2011-01-01

A number of physics data libraries for Monte Carlo simulation are reviewed. The development of a package for the management of physics data is described: its design, implementation and computational benchmarks. This package improves the data management tools originally developed for Geant4 electromagnetic physics models based on data libraries. The implementation exploits recent evolutions of the C++ libraries appearing in the C++0x draft, which are intended for inclusion in the next C++ ISO Standard. The new tools improve the computational performance of physics data management.

News from the Library

CERN Multimedia

CERN Library

2010-01-01

The LHC Library to be merged with the Central Library. Not everyone knows that CERN Scientific Information Service currently counts three physical libraries on site. The Central Library is located in Building 52 and there are two satellite libraries located respectively in building 30 (the LHC Library) and in building 864 on Prévessin site (the SPS Library). Moreover, the Legal Service Library is located in Building 60. In the past, there have been at CERN up to 6 satellite libraries; they were essential at a time when information was only in paper form and having multiple copies of documents located in several places at CERN was useful to facilitate scientific research. Today, this need is less critical as most of our resources are online. That is why, following a SIPB (Scientific Information Policy Board) decision, the collections of the LHC Library will be merged this summer with the Central collection. This reorganization and centralization of resources will improve loan services. The SP...

Coupled fvGCM-GCE Modeling System, 3D Cloud-Resolving Model and Cloud Library

Science.gov (United States)

Tao, Wei-Kuo

2005-01-01

Recent GEWEX Cloud System Study (GCSS) model comparison projects have indicated that cloud- resolving models (CRMs) agree with observations better than traditional single-column models in simulating various types of clouds and cloud systems from different geographic locations. Current and future NASA satellite programs can provide cloud, precipitation, aerosol and other data at very fine spatial and temporal scales. It requires a coupled global circulation model (GCM) and cloud-scale model (termed a super-parameterization or multi-scale modeling framework, MMF) to use these satellite data to improve the understanding of the physical processes that are responsible for the variation in global and regional climate and hydrological systems. The use of a GCM will enable global coverage, and the use of a CRM will allow for better and more sophisticated physical parameterization. NASA satellite and field campaign cloud related datasets can provide initial conditions as well as validation for both the MMF and CRMs. A seed fund is available at NASA Goddard to build a MMF based on the 2D Goddard Cumulus Ensemble (GCE) model and the Goddard finite volume general circulation model (fvGCM). A prototype MMF in being developed and production runs will be conducted at the beginning of 2005. In this talk, I will present: (1) A brief review on GCE model and its applications on precipitation processes, ( 2 ) The Goddard MMF and the major difference between two existing MMFs (CSU MMF and Goddard MMF), (3) A cloud library generated by Goddard MMF, and 3D GCE model, and (4) A brief discussion on the GCE model on developing a global cloud simulator.

Library Research and Statistics. Research on Libraries and Librarianship in 2002; Number of Libraries in the United States and Canada; Highlights of NCES Surveys; Library Acquisition Expenditures, 2001-2002: U.S. Public, Academic, Special, and Government Libraries; LJ Budget Report: A Precarious Holding Pattern; Price Indexes for Public and Academic Libraries; Library Buildings 2002: The Building Buck Doesn't Stop Here.

Science.gov (United States)

Lynch, Mary Jo; Oder, Norman; Halstead, Kent; Fox, Bette-Lee

2003-01-01

Includes seven reports that discuss research on libraries and librarianship, including academic, public, and school libraries; awards and grants; number of libraries in the United States and Canada; National Center for Education Statistics results; library expenditures for public, academic, special, and government libraries; library budgets; price…

Application of Data Mining in Library-Based Personalized Learning

Directory of Open Access Journals (Sweden)

Lin Luo

2017-12-01

Full Text Available this paper expounds to mine up data with the DBSCAN algorithm in order to help teachers and students find which books they expect in the sea of library. In the first place, the model that DBSCAN algorithm applies in library data miner is proposed, followed by the DBSCAN algorithm improved on demands. In the end, an experiment is cited herein to validate this algorithm. The results show that the book price and the inventory level in the library produce a less impact on the resultant aggregation than the classification of books and the frequency of book borrowings. Library procurers should therefore purchase and subscribe data based on the results from cluster analysis thereby to improve hierarchies and structure distribution of library resources, forging on the library resources to be more scientific and reasonable, while it is also conducive to arousing readers' borrowing interest.

Science & Technology Digital Library

OpenAIRE

Solodovnik, Iryna

2014-01-01

This document contains information on the activities carried out within the project Science & Technology Digital Library and in particular, it describes the Metadata Core Reference Model. Metadata are strategic for semantic interoperability to and, from the repository. Metadata are essential for available and safe management of digital objects, and for their sustainability and preservation. For these reasons, the project needs to define a specific metadata model. The purpose of this document ...

Recent developments in the Sesame equation-of-state library

International Nuclear Information System (INIS)

Bennett, B.I.; Johnson, J.D.; Kerley, G.I.; Rood, G.T.

1978-02-01

The Sesame Library is a computer file of tabular equations of state and other material properties, developed in Group T-4 of the Los Alamos Scientific Laboratory. This report describes some of the theoretical models used in the library, the structure of the data storage and acquisition system, and the computer routines that were developed to access and use the tables in practical applications. It also discusses how non-LASL users can obtain the Sesame data and subroutine libraries

Chat reference service in medical libraries: part 2--Trends in medical school libraries.

Science.gov (United States)

Dee, Cheryl R

2003-01-01

An increasing number of medical school libraries offer chat service to provide immediate, high quality information at the time and point of need to students, faculty, staff, and health care professionals. Part 2 of Chat Reference Service in Medical Libraries presents a snapshot of the current trends in chat reference service in medical school libraries. In late 2002, 25 (21%) medical school libraries provided chat reference. Trends in chat reference services in medical school libraries were compiled from an exploration of medical school library Web sites and informal correspondence from medical school library personnel. Many medical libraries are actively investigating and planning new chat reference services, while others have decided not to pursue chat reference at this time. Anecdotal comments from medical school library staff provide insights into chat reference service.

STUDY TO DEVELOP A RESEARCH PROGRAM FOR THE DESIGN DEVELOPMENT OF MODERN COLLEGE LIBRARIES. FINAL REPORT.

Science.gov (United States)

Historical Evaluation and Research Organization, McLean, VA.

THIS STUDY FORMULATES A RESEARCH PROGRAM TO FACILITATE THE ESTABLISHMENT OF LIBRARIES FOR SMALL LIBERAL ARTS COLLEGES USING MODERN LIBRARY METHODS AND TECHNOLOGY AND NEW TECHNIQUES OF INFORMATION STORAGE, RETRIEVAL AND TRANSFER. AS A RESULT OF INTERVIEWS WITH LIBRARIANS AND OTHERS IN THE UNITED STATES AND EUROPE AND FROM A REVIEW OF CURRENT…

Towards Implementing Library 2.0 Model in Nigerian University ...

African Journals Online (AJOL)

It presents the key features of library 2.0, such as user centered, multi-media ... blogs and wikis, instant messaging (IM), podcasts, social networking, streaming media, ... Recommendations were therefore proffered to include; the partnership of ...

Main Libraries, Branches, and Bookmobiles: FY 2013 Public Libraries Survey (Outlet)

Data.gov (United States)

Institute of Museum and Library Services — Find key information on main libraries, branches, and bookmobiles, including FSCS IDs and location.These data include imputed values for libraries that did not...

Keys to Success for Library Paraprofessionals and Support Staff.

Science.gov (United States)

Leonhardt, Thomas W.

1996-01-01

Suggests that libraries use a military model of organization, in favor of a big-business approach, to address job dissatisfaction among paraprofessional staff. Military concepts that transfer to the library milieu include clear responsibility delineations, demonstrable recognition of the value of individual workers, continuing education programs,…

Five Aspects of Current Trends in German Library Science

Science.gov (United States)

Steierwald, Ulrike

2006-01-01

The specialisation Library Science at the Hochschule Darmstadt/University of Applied Science Darmstadt is the newest academic program in Germany for the higher education of librarians. Five current trends in library science in Germany reflect the new "Darmstadt Model": (1) The delimitation of a specific professional field…

Afghanistan Digital Library Initiative: Revitalizing an Integrated Library System

Directory of Open Access Journals (Sweden)

Yan HAN

2007-12-01

Full Text Available This paper describes an Afghanistan digital library initiative of building an integrated library system (ILS for Afghanistan universities and colleges based on open-source software. As one of the goals of the Afghan eQuality Digital Libraries Alliance, the authors applied systems analysis approach, evaluated different open-source ILSs, and customized the selected software to accommodate users’ needs. Improvements include Arabic and Persian language support, user interface changes, call number label printing, and ISBN-13 support. To our knowledge, this ILS is the first at a large academic library running on open-source software.

Presentation of the selected French libraries and the French library system

Directory of Open Access Journals (Sweden)

Moja Kotar

2007-01-01

Full Text Available The Selected French libraries (Bibliotheque nationale de France, Bibliotheque publique d’information, multimedia library of the Cité des sciences et de l’industrie as well as Paris public libraries are presented in the article. France does not have a union catalogue at the national level, therefore libraries use different platforms for shared cataloguing and compile more union catalogues. According to their needs, French libraries join into consortia for the acquisition of electronic resources, which can be either geographically or thematically delimited or formed by the institutions of the same status. The author believes that the Slovenian library network works well considering much smaller budget for culture and higher education in comparison with France. To improve its performance, more funds would have to be allocated and higher reputation of the library profession achieved, comparable to the situation in France. Digitization of resources is the area where the Slovenian librarianship lags most behind the French one.

Models of Reference Services in Australian Academic Libraries

Science.gov (United States)

Burke, Liz

2008-01-01

This article reports on a project which was undertaken in 2006 to investigate the current modes and methods for delivering reference services in Australian academic libraries. The project included a literature review to assist in providing a definition of reference services as well as a snapshot of statistics showing staff and patron numbers from…

A Structural Contingency Theory Model of Library and Technology Partnerships within an Academic Library Information Commons

Science.gov (United States)

Tuai, Cameron K.

2011-01-01

The integration of librarians and technologists to deliver information services represents a new and potentially costly organizational challenge for many library administrators. To understand better how to control the costs of integration, the research presented here will use structural contingency theory to study the coordination of librarians…