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Sample records for model showed excellent

  1. Model of excellent kindergarten learning for excellent pupils

    NARCIS (Netherlands)

    Dijkstra, Elma; Mooij, Ton; Kirschner, Paul A.

    2012-01-01

    Dijkstra, E. M., Mooij, T., & Kirschner, P. A. (2012, 9 November). Model of excellent kindergarten learning for excellent pupils. Poster presentation at the International ICO Fall School, Girona, Spain.

  2. Model of Excellent Kindergarten Learning for Excellent Pupils

    NARCIS (Netherlands)

    Dijkstra, Elma; Mooij, Ton; Kirschner, Paul A.

    2012-01-01

    Dijkstra, E. M., Mooij, T., & Kirschner, P. A. (2012, 11 October). Model of excellent kindergarten learning for excellent pupils. Poster presentation at the Teacher Expertise Symposium, University of Utrecht, Utrecht, The Netherlands.

  3. Solving rational expectations models using Excel

    DEFF Research Database (Denmark)

    Strulik, Holger

    2004-01-01

    Problems of discrete time optimal control can be solved using backward iteration and Microsoft Excel. The author explains the method in general and shows how the basic models of neoclassical growth and real business cycles are solved......Problems of discrete time optimal control can be solved using backward iteration and Microsoft Excel. The author explains the method in general and shows how the basic models of neoclassical growth and real business cycles are solved...

  4. Production management using the EFQM Excellence Model

    Directory of Open Access Journals (Sweden)

    Janja Škedel

    2016-09-01

    Full Text Available Research Question (RQ: Comparison of production management using the EFQM Excellence Model. Purpose: The aim of the research is based on a comparison of production management using the EFQM Excellence Model, to establish identity and difference. The aim is to improve the management of production and by using the model closer to excellence. Method: An identification method of benchmarking. Results: The results show tolerance, which represent an opportunity to improve production management with excellence. Organization: If we take into account the results of the organization, this would be an asset to the organization. Society: Method comparisons can also be used in the wider environment. Originality: The survey is unique and the first of its kind in the manufacturing organization. Limitations/Future Research: With this research we will gain improvements in production management through design excellence.

  5. Hotel shows health system keys to service excellence.

    Science.gov (United States)

    2003-08-01

    Ritz-Carlton partnership part of broader program pursuing service excellence. Nearly 600 system leaders will participate in day-long seminars. GE, Harvard serve as strategic partners for ongoing educational efforts.

  6. The Business Excellence Model for CSR Implementation?

    Directory of Open Access Journals (Sweden)

    Neergaard Peter

    2014-11-01

    Full Text Available Most of the Fortune 500 companies address Corporate Social Responsibility (CSR on their websites. However, CSR remains a fluffy concept difficult to implement in organization. The European Business Excellence Model has since the introduction in 1992 served as a powerful tool for integrating quality in organizations. CSR was first introduced in the model in 2002. From 2004 the European Foundation for Quality Management (EFQM has been eager to promote the model as an effective tool for implementing CSR.. The article discusses the potentials of the model for this end and illustrates how a 2006 European Award winning company has used the model to integrate CSR. The company adapted the Business Excellence model to improve performance, stimulate innovation and consensus.

  7. The Business Excellence Model for CSR Implementation?

    DEFF Research Database (Denmark)

    Neergaard, Peter; Gjerdrum Pedersen, Esben Rahbek

    2012-01-01

    Most of the Fortune 500 companies address Corporate Social Responsibility (CSR) on their websites. However, CSR remains a fluffy concept difficult to implement in organization. The European Business Excellence Model has since the introduction in 1992 served as a powerful tool for integrating qual...

  8. Visual Basic and Excel in Chemical Modeling

    Science.gov (United States)

    Kaess, Michael; Easter, Jesse; Cohn, Kim

    1998-05-01

    A series of modules were prepared to model some topics in molecular mechanics and computational chemistry. In order to make modules that would be useful in personal, academic or professional situations and to make them easy to use on both IBM and Macintosh compatible computers as well as require little or no computational, advanced mathematical or programming skills we settled on Microsoft Excel as the program of choice. The release of Excel 5.0 incorporates Visual Basic. This allows the use of custom commands, menus, dialog boxes, buttons and custom on-line help.

  9. Excel Modelling - Transparency, Auditing and Business Use

    CERN Document Server

    Allan, Susan

    2009-01-01

    Within Lloyds Banking Group the heritage HBOS Corporate division deals with Corporate loans, and is required to assess these loans for risk in accordance with the Basle Accord regulations. Statistical Risk Rating models are developed by the risk analysts to assess the obligors credit worthiness. It is necessary then to provide the bankers who originated the loan ('Relationship Managers' or RMs) with an assessment tool to generate the loan rating upon which they base their lending decisions. Heritage HBoS Corporate required a new model build system for holding its Risk Rating models in 2006 as a result of more complex models being created to comply with the Basle Accord. The use of Excel was promoted by the IT department for a number of reasons; the Excel solution now in use is reviewed in this paper.

  10. Role modeling excellence in clinical nursing practice.

    Science.gov (United States)

    Perry, R N Beth

    2009-01-01

    Role modeling excellence in clinical nursing practice is the focus of this paper. The phenomenological research study reported involved a group of 8 nurses identified by their colleagues as exemplary. The major theme revealed in this study was that these exemplary nurses were also excellent role models in the clinical setting. This paper details approaches used by these nurses that made them excellent role models. Specifically, the themes of attending to the little things, making connections, maintaining a light-hearted attitude, modeling, and affirming others are presented. These themes are discussed within the framework of Watson [Watson, J., 1989. Human caring and suffering: a subjective model for health services. In: Watson, J., Taylor, R. (Eds.), They Shall Not Hurt: Human Suffering and Human Caring. Colorado University, Boulder, CO] "transpersonal caring" and [Bandura, A., 1997. Social Learning Theory. Prentice Hall, Englewood Cliffs, NJ] "Social Learning Theory." Particular emphasis in the discussion is on how positive role modeling by exemplary practitioners can contribute to the education of clinical nurses in the practice setting.

  11. Use of a business excellence model to improve conservation programs.

    Science.gov (United States)

    Black, Simon; Groombridge, Jim

    2010-12-01

    The current shortfall in effectiveness within conservation biology is illustrated by increasing interest in "evidence-based conservation," whose proponents have identified the need to benchmark conservation initiatives against actions that lead to proven positive effects. The effectiveness of conservation policies, approaches, and evaluation is under increasing scrutiny, and in these areas models of excellence used in business could prove valuable. Typically, conservation programs require years of effort and involve rigorous long-term implementation processes. Successful balance of long-term efforts alongside the achievement of short-term goals is often compromised by management or budgetary constraints, a situation also common in commercial businesses. "Business excellence" is an approach many companies have used over the past 20 years to ensure continued success. Various business excellence evaluations have been promoted that include concepts that could be adapted and applied in conservation programs. We describe a conservation excellence model that shows how scientific processes and results can be aligned with financial and organizational measures of success. We applied the model to two well-documented species conservation programs. In the first, the Po'ouli program, several aspects of improvement were identified, such as more authority for decision making in the field and better integration of habitat management and population recovery processes. The second example, the black-footed ferret program, could have benefited from leadership effort to reduce bureaucracy and to encourage use of best-practice species recovery approaches. The conservation excellence model enables greater clarity in goal setting, more-effective identification of job roles within programs, better links between technical approaches and measures of biological success, and more-effective use of resources. The model could improve evaluation of a conservation program's effectiveness and may be

  12. Overcoming Microsoft Excel's Weaknesses for Crop Model Building and Simulations

    Science.gov (United States)

    Sung, Christopher Teh Boon

    2011-01-01

    Using spreadsheets such as Microsoft Excel for building crop models and running simulations can be beneficial. Excel is easy to use, powerful, and versatile, and it requires the least proficiency in computer programming compared to other programming platforms. Excel, however, has several weaknesses: it does not directly support loops for iterative…

  13. Manufacturing Excellence Approach to Business Performance Model

    Directory of Open Access Journals (Sweden)

    Jesus Cruz Alvarez

    2015-03-01

    Full Text Available Six Sigma, lean manufacturing, total quality management, quality control, and quality function deployment are the fundamental set of tools to enhance productivity in organizations. There is some research that outlines the benefit of each tool into a particular context of firm´s productivity, but not into a broader context of firm´s competitiveness that is achieved thru business performance. The aim of this theoretical research paper is to contribute to this mean and propose a manufacturing excellence approach that links productivity tools into a broader context of business performance.

  14. Proposing an Environmental Excellence Self-Assessment Model

    DEFF Research Database (Denmark)

    Meulengracht Jensen, Peter; Johansen, John; Wæhrens, Brian Vejrum

    2013-01-01

    This paper presents an Environmental Excellence Self-Assessment (EEA) model based on the structure of the European Foundation of Quality Management Business Excellence Framework. Four theoretical scenarios for deploying the model are presented as well as managerial implications, suggesting...... that the EEA model can be used in global organizations to differentiate environmental efforts depending on the maturity stage of the individual sites. Furthermore, the model can be used to support the decision-making process regarding when organizations should embark on more complex environmental efforts...... to continue to realize excellent environmental results. Finally, a development trajectory for environmental excellence is presented....

  15. Applying the model of excellence in dental healthcare

    Directory of Open Access Journals (Sweden)

    Tekić Jasmina

    2015-01-01

    Full Text Available Introduction. Models of excellence are considered a practical tool in the field of management that should help a variety of organizations, including dental, to carry out the measurement of the quality of provided services, and so define their position in relation to excellence. The quality of healthcare implies the degree within which the system of healthcare and health services increases the likelihood of positive treatment outcome. Objective. The aim of the present study was to define a model of excellence in the field of dental healthcare (DHC in the Republic of Serbia and suggest the model of DHC whose services will have the characteristics of outstanding service in the dental practice. Methods. In this study a specially designed questionnaire was used for the assessment of the maturity level of applied management regarding quality in healthcare organizations of the Republic of Serbia. The questionnaire consists of 13 units and a total of 240 questions. Results. The results of the study were discussed involving four areas: (1 defining the main criteria and sub-criteria, (2 the elements of excellence of DHC in the Republic of Serbia, (3 the quality of DHC in the Republic of Serbia, and (4 defining the framework of the model of excellence for the DHC in the Republic of Serbia. The main criteria which defined the framework and implementation model of excellence in the field of DHC in Serbia were: leadership, management, human resources, policy and strategy, other resources, processes, patients’ satisfaction, employee’s satisfaction, impact on society and business results. The model had two main parts: the possibilities for the first five criteria and options for the other four criteria. Conclusion. Excellence in DHC business as well as the excellence of provided dental services are increasingly becoming the norm and good practice, and progressively less the exception.

  16. An Excel[TM] Model of a Radioactive Series

    Science.gov (United States)

    Andrews, D. G. H.

    2009-01-01

    A computer model of the decay of a radioactive series, written in Visual Basic in Excel[TM], is presented. The model is based on the random selection of cells in an array. The results compare well with the theoretical equations. The model is a useful tool in teaching this aspect of radioactivity. (Contains 4 figures.)

  17. Building Higher-Order Markov Chain Models with EXCEL

    Science.gov (United States)

    Ching, Wai-Ki; Fung, Eric S.; Ng, Michael K.

    2004-01-01

    Categorical data sequences occur in many applications such as forecasting, data mining and bioinformatics. In this note, we present higher-order Markov chain models for modelling categorical data sequences with an efficient algorithm for solving the model parameters. The algorithm can be implemented easily in a Microsoft EXCEL worksheet. We give a…

  18. USING THE SOFTWARE MICROSOFT OFFICE EXCEL FOR FINANCIAL MODELING DECISION

    Directory of Open Access Journals (Sweden)

    Bălăc escu Aniela

    2009-05-01

    Full Text Available The use of the software package is today indispensable for modeling of financial decisions. Business organizations will invariably make greater demands of the software than individual users. Excel is an option along with other software applications tailored to the market, and bespoke (in-house software packages. It should be noted that Excel is the leader in the market and as such does set a benchmark.

  19. Designing organizational excellence model for cellulose industry of Iran

    Directory of Open Access Journals (Sweden)

    Seyed Abbas Kazemi

    2012-01-01

    Full Text Available Nowadays organizational excellence is regarded as the world’s most effective and progressive issue and many countries and organizations are attempting in the way of applying excellence. In this way, they attempt to improve such models and according to culture and sociopolitical conditions of each country, they attempt to design several models. The present research has been conducted with principal goal of designing organizational excellence model at cellulose industry of Iran. The study determines its components and aspects, priorities the aspects and components and analyzes relationship among different aspects of organizational excellence model at cellulose industry of Iran. The present research is an applied research with respect to goal and it is a descriptive-analytical method in terms of method. Statistical population of the present research covers all experts in the field of cellulose industry of Iran in which on this basis, the number of statistical sample was 207 people from managers to specialists. Results of research indicate that organizational excellence pattern of cellulose industry is a mixture of different aspects of technical, economic, inner environment, outer environment, motivation and behavioral processes.

  20. Hacker's guide to Microsoft Excel (how to use Excel, shortcuts, modeling, macros, and more)

    CERN Document Server

    Hudson, Kimberly

    2012-01-01

    ABOUT THE BOOK Microsoft Excel is a user-friendly spreadsheet program that lets you organize data, create charts, program time-saving shortcuts, and make reports. It is part of the Microsoft Office Suite. There are multiple versions of Microsoft Excel out there, the latest being part of the Microsoft Office 2010 Suite. Although you may be baffled by Excel now, don't give up! Once you read what Excel can do, you will quickly use simple functions to answer questions, create charts, and increase productivity. MEET THE AUTHOR Kimberly Hudson is a professional writer who lives and works in Ma

  1. Microsoft Office Excel 2007 data analysis and business modeling

    CERN Document Server

    Winston, Wayne L

    2007-01-01

    Master the analysis and business modeling techniques that help you transform your data into bottom-line results. Award-winning business professor and corporate consultant Wayne Winston shares the best of his real-world experience in this practical guide-now updated for Excel 2007. Use Wayne's proven practices and hands-on exercises to help you work smarter, make better decisions, and gain the competitive edge. Solve real-world business problems with Excel 2007! Maximize profits-determine NPV, optimize your product mix, calculate ROICreate best, worst, and most-likely case scenarios for sal

  2. Mathematical Model and Programming in VBA Excel for Package Calculation

    Directory of Open Access Journals (Sweden)

    João Daniel Reis Lessa

    2016-05-01

    Full Text Available The industrial logistics is a fundamental pillar for the survival of companies in the actual increasingly competitive market. It is not exclusively about controlling the flow of external material between suppliers and the company, but for developing a detailed study of how to plan, control, handle and package those materials as well. Logistics activities must ensure the maximum efficiency in using corporate resources once they do not add value to the final product. The creation of a logistic plan, for each piece of the company’s production, has to adapt the demand parameters, seasonal or not, in the timeline. Thus, the definition of packaging (transportation and consumption must adjust in accordance with the demand, in order to allow the logistic planning to work, constantly, with order of economy batches. The packaging calculation for each part in every demand can become well complicated due to the large amount of parts in the production process. Automating the calculation process for choosing the right package for each piece is an effective method in logistics planning. This article will expose a simple and practical mathematical model for automating the packaging calculation and a logic program, created in Visual Basic language in the Excel software, used for creating graphic designs that show how the packages are being filled.

  3. Nanorods of a new metal-biomolecule coordination polymer showing novel bidirectional electrocatalytic activity and excellent performance in electrochemical sensing.

    Science.gov (United States)

    Yang, Jiao; Zhou, Bo; Yao, Jie; Jiang, Xiao-Qing

    2015-05-15

    Metal organic coordination polymers (CPs), as most attractive multifunctional materials, have been studied extensively in many fields. However, metal-biomolecule CPs and CPs' electrochemical properties and applications were studied much less. We focus on this topic aiming at electrochemical biosensors with excellent performance and high biocompatibility. A new nanoscaled metal-biomolecule CP, Mn-tyr, containing manganese and tyrosine, was synthesized hydrothermally and characterized by various techniques, including XRD, TEM, EDS, EDX mapping, elemental analysis, XPS, and IR. Electrode modified with Mn-tyr showed novel bidirectional electrocatalytic ability toward both reduction and oxidation of H2O2, which might be due to Mn. With the assistance of CNTs, the sensing performance of Mn-tyr/CNTs/GCE was improved to a much higher level, with high sensitivity of 543 mA mol(-1) L cm(-2) in linear range of 1.00×10(-6)-1.02×10(-4) mol L(-1), and detection limit of 3.8×10(-7) mol L(-1). Mn-tyr/CNTs/GCE also showed fast response, high selectivity, high steadiness and reproducibility. The excellent performance implies that the metal-biomolecule CPs are promising candidates for using in enzyme-free electrochemical biosensing.

  4. Performance Evaluation Based on EFQM Excellence Model in Sport Organizations

    Directory of Open Access Journals (Sweden)

    Rasoul Faraji

    2012-06-01

    Full Text Available The present study aims to evaluate the performance of physical education (P.E. general office of Tehran province through model of European Foundation for Quality Management (EFQM. Questionnaire approach was used in this study. Therefore validity of the 50-item EFQM questionnaire verified by the experts and the reliability also calculated in a pilot study (α=0.928. 95 questionnaires distributed between subjects (N=n and 80 questionnaires returned and concluded in the statistical analysis. From nine EFQM criteria, the highest scores were gained in key performance results (37.62% and the lowest gained in people results (27.94%. Totally, this organization achieved 337.11 pointes out of a total of 1000. Additionally, there was a strong relationship (r=0.827, p=0.001 between enablers and results (P<0.05. Based on scores gained in the criteria, improving measures in all criteria is essential for this organization, especially in the people criterion from enablers and people results criterion from results domain. Furthermore, it is believed that the physical education area is one of the best fields for application of the excellence model towards the performance excellence and gaining better results and hence, it seems that the model has a high potential in responding to problems commonly seen in sport sector.

  5. Model voor Excellent voor cognitief excellente leerlingen in de onderbouw PO

    NARCIS (Netherlands)

    Dijkstra, Elma; Mooij, Ton; Kirschner, Paul A.

    2012-01-01

    Dijkstra, E. M., Mooij, T., & Kirschner, P. A. (2012, June). Model voor Excellent Onderwijs voor cognitief excellent leerlingen in de onderbouw PO. [Model of Excellent Education for cognitively excellent pupils in kindergarten]. Paper presented at the Onderwijs Research Dagen [Educational Research

  6. Model voor Excellent voor cognitief excellente leerlingen in de onderbouw PO

    NARCIS (Netherlands)

    Dijkstra, Elma; Mooij, Ton; Kirschner, Paul A.

    2012-01-01

    Dijkstra, E. M., Mooij, T., & Kirschner, P. A. (2012, June). Model voor Excellent Onderwijs voor cognitief excellent leerlingen in de onderbouw PO. [Model of Excellent Education for cognitively excellent pupils in kindergarten]. Paper presented at the Onderwijs Research Dagen [Educational Research D

  7. Excel Spreadsheets for Algebra: Improving Mental Modeling for Problem Solving

    Science.gov (United States)

    Engerman, Jason; Rusek, Matthew; Clariana, Roy

    2014-01-01

    This experiment investigates the effectiveness of Excel spreadsheets in a high school algebra class. Students in the experiment group convincingly outperformed the control group on a post lesson assessment. The student responses, teacher observations involving Excel spreadsheet revealed that it operated as a mindtool, which formed the users'…

  8. Best practices in academic mentoring: a model for excellence.

    Science.gov (United States)

    Nick, Jan M; Delahoyde, Theresa M; Del Prato, Darlene; Mitchell, Claudia; Ortiz, Jennifer; Ottley, Clarise; Young, Patricia; Cannon, Sharon B; Lasater, Kathie; Reising, Deanna; Siktberg, Linda

    2012-01-01

    Mentoring is important for the recruitment and retention of qualified nurse faculty, their ongoing career development, and leadership development. However, what are current best practices of mentoring? The purpose of this paper is to provide an overview of a model for excellence in establishing a formal mentoring program for academic nurse educators. Six themes for establishing a formal mentoring program are presented, highlighting best practices in mentoring as culled from experience and the literature. Themes reflect aims to achieve appropriately matched dyads, establish clear mentorship purpose and goals, solidify the dyad relationship, advocate for and guide the protégé, integrate the protégé into the academic culture, and mobilize institutional resources for mentoring support. Attending to the six themes will help mentors achieve important protégé outcomes, such as orientation to the educator role, integration into the academic community, development of teaching, scholarship, and service skills, as well as leadership development. The model is intended to be generalizable for faculty teaching in a variety of academic nursing institution types and sizes. Mentoring that integrates the six themes assists faculty members to better navigate the academic environment and more easily transition to new roles and responsibilities.

  9. Best Practices in Academic Mentoring: A Model for Excellence

    Directory of Open Access Journals (Sweden)

    Jan M. Nick

    2012-01-01

    Full Text Available Mentoring is important for the recruitment and retention of qualified nurse faculty, their ongoing career development, and leadership development. However, what are current best practices of mentoring? The purpose of this paper is to provide an overview of a model for excellence in establishing a formal mentoring program for academic nurse educators. Six themes for establishing a formal mentoring program are presented, highlighting best practices in mentoring as culled from experience and the literature. Themes reflect aims to achieve appropriately matched dyads, establish clear mentorship purpose and goals, solidify the dyad relationship, advocate for and guide the protégé, integrate the protégé into the academic culture, and mobilize institutional resources for mentoring support. Attending to the six themes will help mentors achieve important protégé outcomes, such as orientation to the educator role, integration into the academic community, development of teaching, scholarship, and service skills, as well as leadership development. The model is intended to be generalizable for faculty teaching in a variety of academic nursing institution types and sizes. Mentoring that integrates the six themes assists faculty members to better navigate the academic environment and more easily transition to new roles and responsibilities.

  10. Best Practices in Academic Mentoring: A Model for Excellence

    Science.gov (United States)

    Nick, Jan M.; Delahoyde, Theresa M.; Del Prato, Darlene; Mitchell, Claudia; Ortiz, Jennifer; Ottley, Clarise; Young, Patricia; Cannon, Sharon B.; Lasater, Kathie; Reising, Deanna; Siktberg, Linda

    2012-01-01

    Mentoring is important for the recruitment and retention of qualified nurse faculty, their ongoing career development, and leadership development. However, what are current best practices of mentoring? The purpose of this paper is to provide an overview of a model for excellence in establishing a formal mentoring program for academic nurse educators. Six themes for establishing a formal mentoring program are presented, highlighting best practices in mentoring as culled from experience and the literature. Themes reflect aims to achieve appropriately matched dyads, establish clear mentorship purpose and goals, solidify the dyad relationship, advocate for and guide the protégé, integrate the protégé into the academic culture, and mobilize institutional resources for mentoring support. Attending to the six themes will help mentors achieve important protégé outcomes, such as orientation to the educator role, integration into the academic community, development of teaching, scholarship, and service skills, as well as leadership development. The model is intended to be generalizable for faculty teaching in a variety of academic nursing institution types and sizes. Mentoring that integrates the six themes assists faculty members to better navigate the academic environment and more easily transition to new roles and responsibilities. PMID:22685645

  11. A Survey of Level of Excellence in National Library and Archives of I.R. of Iran Based on EFQM Excellence Model

    Directory of Open Access Journals (Sweden)

    Elaheh Hassanzadeh

    2013-03-01

    Full Text Available EFQM excellence model as a framework for evaluation and improvement in organizations indicates some advantages which an excellent organization should achieve. Furthermore, based on its position and the type of service it offers, NLAI needs an all-out study using EFQM model. So the current research aimed at determining level of excellence in NLAI based on EFQM excellence model. The research method was descriptive. Statistical society consisted of top and middle managers of NLAI. Data was gathered through the proportionate EFQM's 90 questions questionnaire. The results from descriptive statistics showed that the mean of NLAI performance self-assessment was acquired in 9 criteria of EFQM model: leadership 56 out of 100, policy and strategy 34 out of 80, people 52 out of 90, partnership and resources 62 out of 90, processes 41 out of 140, customer results 80 out of 200, people results40 out of 90, society results 31 out of 60, key performance results 96 out of 150. Finally, the NLAI gained 492 out of 1000 points. Among all the criteria of the model, partnership criteria and resources have achieved the highest score (62 points of 90 and process criteria lowest score (41 points of 140. Therefore NLAI should be improving the process to meet the complete satisfaction and added value for users and other stakeholders. The results also showed that the EFQM was a good framework for self-assessment on of the EFQM model at NLAI and a good system for identifying strengths and areas for improvement.

  12. [Application of three compartment model and response surface model to clinical anesthesia using Microsoft Excel].

    Science.gov (United States)

    Abe, Eiji; Abe, Mari

    2011-08-01

    With the spread of total intravenous anesthesia, clinical pharmacology has become more important. We report Microsoft Excel file applying three compartment model and response surface model to clinical anesthesia. On the Microsoft Excel sheet, propofol, remifentanil and fentanyl effect-site concentrations are predicted (three compartment model), and probabilities of no response to prodding, shaking, surrogates of painful stimuli and laryngoscopy are calculated using predicted effect-site drug concentration. Time-dependent changes in these calculated values are shown graphically. Recent development in anesthetic drug interaction studies are remarkable, and its application to clinical anesthesia with this Excel file is simple and helpful for clinical anesthesia.

  13. Bringing Excellence to Automotive

    Science.gov (United States)

    Večeřa, Pavel; Paulová, Iveta

    2012-12-01

    Market situation and development in recent years shows, that organization's ability to meet customer requirements is not enough. Successful organizations are able to exceed the expectations of all stakeholders. They are building their excellence systematically. Our contribution basically how the excellence in automotive is created using EFQM Excellence Model in Total Quality Management.

  14. an integrated service excellence model for strategic military test and ...

    African Journals Online (AJOL)

    gerhardc

    The purpose of this article is to introduce an Integrated Service Excellence ... processes exist in these facilities without any common quality assurance and control ... provide strategic military test and evaluation facility services and to continuously .... customer satisfaction surveys where customer inputs should be considered.

  15. Duration Modeling in Undergraduate Econometrics Curriculum via Excel

    Directory of Open Access Journals (Sweden)

    Ismail H. Genc

    2004-01-01

    Full Text Available The main goal of an Econometrics course is to prepare students for more advanced levels of study and make them able to cope with the empirical problems they are likely to face. In recent years, there has been a tendency to purge merely theoretical topics from the econometric textbooks by including only time honored methods. Survival analysis, however, has so far failed to attract the attention of textbook writers. I conjecture that the general perception of the issue as an advanced topic as well as software barriers have led to this attitude. In this study, I work out an Excel file to outline the fundamental concepts of duration analysis at an introductory level. The file so generated may also be used by practitioners in appropriate cases with minimal learning cost. As such, I hope to dissipate the myth of difficulty associated with this subject matter.

  16. The Y-12 Plant - a model for environmental excellence

    Energy Technology Data Exchange (ETDEWEB)

    1994-11-01

    The Department of Energy`s Y-12 Plant, located in Oak Ridge, Tennessee, occupies more than 800 acres and has a work force of over 4,000 employees. The Y-12 Plant is managed by Martin Marietta Energy Systems, Inc., a subsidiary of Martin Marietta Corporation. Although mission emphases at the Y-12 Plant have evolved and changed with the easing of international tensions, the Plant continues to serve as a key manufacturing unit and technology demonstration center for the Department of Energy and the nation. The Y-12 Plant has undergone many changes in the last 14 years. One of the most dramatic changes has occurred in the environmental programs with measurable improvements in environmental quality, the development of an award-winning pollution prevention program, and the institution of an environmentally-conscious work ethic among the work force. Because the plant is committed to achieving excellence, not just compliance with laws and regulations, a highly structured, multimedia environmental management program is in place. This program, combined with a commitment to protect the environment while striving for continued improvement, has placed Y-12 in the position to reach excellence. As a result of the Y-12 Plant`s changing mission, they are now working closely with American industry through technology transfer to share their experiences and {open_quotes}lessons learned{close_quotes}--including environmental and pollution prevention technology. To facilitate this effort, the Oak Ridge Centers for Manufacturing Technology has been established at the Y-12 Plant. Through the Centers, the Oak Ridge staff applies skills, capabilities, and facilities developed over a 50-year history of the Oak Ridge Complex to a variety of peacetime missions. The services found at the Centers are a key to helping America`s businesses--both small and large--compete in the global marketplace while protecting the nations environment and conserving its resources.

  17. The Y-12 Plant - a model for environmental excellence

    Energy Technology Data Exchange (ETDEWEB)

    1994-11-01

    The Department of Energy`s Y-12 Plant, located in Oak Ridge, Tennessee, occupies more than 800 acres and has a work force of over 4,000 employees. The Y-12 Plant is managed by Martin Marietta Energy Systems, Inc., a subsidiary of Martin Marietta Corporation. Although mission emphases at the Y-12 Plant have evolved and changed with the easing of international tensions, the Plant continues to serve as a key manufacturing unit and technology demonstration center for the Department of Energy and the nation. The Y-12 Plant has undergone many changes in the last 14 years. One of the most dramatic changes has occurred in the environmental programs with measurable improvements in environmental quality, the development of an award-winning pollution prevention program, and the institution of an environmentally-conscious work ethic among the work force. Because the plant is committed to achieving excellence, not just compliance with laws and regulations, a highly structured, multimedia environmental management program is in place. This program, combined with a commitment to protect the environment while striving for continued improvement, has placed Y-12 in the position to reach excellence. As a result of the Y-12 Plant`s changing mission, they are now working closely with American industry through technology transfer to share their experiences and {open_quotes}lessons learned{close_quotes}--including environmental and pollution prevention technology. To facilitate this effort, the Oak Ridge Centers for Manufacturing Technology has been established at the Y-12 Plant. Through the Centers, the Oak Ridge staff applies skills, capabilities, and facilities developed over a 50-year history of the Oak Ridge Complex to a variety of peacetime missions. The services found at the Centers are a key to helping America`s businesses--both small and large--compete in the global marketplace while protecting the nations environment and conserving its resources.

  18. Parametric modeling of arch dam based on Excel-VBA and APDL%基于Excel-VBA与APDL的拱坝参数化建模方法

    Institute of Scientific and Technical Information of China (English)

    周强

    2015-01-01

    Modeling of arch dam is growing more and more difficult as its complex shape. To get the re-quired coordinates of arch dam modeling, this paper does secondary development of Excel by VBA. And acquired coordinates could generate executable APDL code, which would make establishing double-cur-vature arch dam model more quickly and efficiently. It could save a lot of time for the next simulation analysis and calculation of arch dam. The result shows that the parameterized modeling of arch dam be-comes more convenient and accurate by the method combining Excel-VBA and APDL.%由于拱坝体形较为复杂,拱坝建模难度较大.笔者利用VBA对Excel进行二次开发,得出拱坝建模中所需的点坐标.根据这些点坐标生成ANSYS中可执行的APDL代码,快捷高效地建立了双曲拱坝模型,为此后的拱坝仿真计算创造了条件.实例表明,Excel-VBA与APDL的结合使用,可以使ANSYS中拱坝的参数化建模更为方便和准确.

  19. Excellence in Physics Education Award: Modeling Theory for Physics Instruction

    Science.gov (United States)

    Hestenes, David

    2014-03-01

    All humans create mental models to plan and guide their interactions with the physical world. Science has greatly refined and extended this ability by creating and validating formal scientific models of physical things and processes. Research in physics education has found that mental models created from everyday experience are largely incompatible with scientific models. This suggests that the fundamental problem in learning and understanding science is coordinating mental models with scientific models. Modeling Theory has drawn on resources of cognitive science to work out extensive implications of this suggestion and guide development of an approach to science pedagogy and curriculum design called Modeling Instruction. Modeling Instruction has been widely applied to high school physics and, more recently, to chemistry and biology, with noteworthy results.

  20. A Dynamic Network Model to Explain the Development of Excellent Human Performance.

    Science.gov (United States)

    Den Hartigh, Ruud J R; Van Dijk, Marijn W G; Steenbeek, Henderien W; Van Geert, Paul L C

    2016-01-01

    Across different domains, from sports to science, some individuals accomplish excellent levels of performance. For over 150 years, researchers have debated the roles of specific nature and nurture components to develop excellence. In this article, we argue that the key to excellence does not reside in specific underlying components, but rather in the ongoing interactions among the components. We propose that excellence emerges out of dynamic networks consisting of idiosyncratic mixtures of interacting components such as genetic endowment, motivation, practice, and coaching. Using computer simulations we demonstrate that the dynamic network model accurately predicts typical properties of excellence reported in the literature, such as the idiosyncratic developmental trajectories leading to excellence and the highly skewed distributions of productivity present in virtually any achievement domain. Based on this novel theoretical perspective on excellent human performance, this article concludes by suggesting policy implications and directions for future research.

  1. A dynamic network model to explain the development of excellent human performance

    Directory of Open Access Journals (Sweden)

    Ruud J.R. Den Hartigh

    2016-04-01

    Full Text Available Across different domains, from sports to science, some individuals accomplish excellent levels of performance. For over 150 years, researchers have debated the roles of specific nature and nurture components to develop excellence. In this article, we argue that the key to excellence does not reside in specific underlying components, but rather in the ongoing interactions among the components. We propose that excellence emerges out of dynamic networks consisting of idiosyncratic mixtures of interacting components such as genetic endowment, motivation, practice, and coaching. Using computer simulations we demonstrate that the dynamic network model accurately predicts typical properties of excellence reported in the literature, such as the idiosyncratic developmental trajectories leading to excellence and the highly skewed distributions of productivity present in virtually any achievement domain. Based on this novel theoretical perspective on excellent human performance, this article concludes by suggesting policy implications and directions for future research.

  2. A Dynamic Network Model to Explain the Development of Excellent Human Performance

    Science.gov (United States)

    Den Hartigh, Ruud J. R.; Van Dijk, Marijn W. G.; Steenbeek, Henderien W.; Van Geert, Paul L. C.

    2016-01-01

    Across different domains, from sports to science, some individuals accomplish excellent levels of performance. For over 150 years, researchers have debated the roles of specific nature and nurture components to develop excellence. In this article, we argue that the key to excellence does not reside in specific underlying components, but rather in the ongoing interactions among the components. We propose that excellence emerges out of dynamic networks consisting of idiosyncratic mixtures of interacting components such as genetic endowment, motivation, practice, and coaching. Using computer simulations we demonstrate that the dynamic network model accurately predicts typical properties of excellence reported in the literature, such as the idiosyncratic developmental trajectories leading to excellence and the highly skewed distributions of productivity present in virtually any achievement domain. Based on this novel theoretical perspective on excellent human performance, this article concludes by suggesting policy implications and directions for future research. PMID:27148140

  3. Excel simulations

    CERN Document Server

    Verschuuren, Gerard M

    2013-01-01

    Covering a variety of Excel simulations, from gambling to genetics, this introduction is for people interested in modeling future events, without the cost of an expensive textbook. The simulations covered offer a fun alternative to the usual Excel topics and include situations such as roulette, password cracking, sex determination, population growth, and traffic patterns, among many others.

  4. Redesigning Schools to Reach Every Student with Excellent Teachers: Financial Planning for Time-Technology Swap--Rotation Model

    Science.gov (United States)

    Public Impact, 2012

    2012-01-01

    This brief shows how teachers in a Time-Technology swap school model may earn more, sustainably. In this model, schools use age-appropriate portions of digital learning (as little as about an hour daily per student) to free the time of excellent teachers to teach more students and potentially to collaborate with peers. By teaching more students,…

  5. A 3D MOF showing unprecedented solvent-induced single-crystal-to-single-crystal transformation and excellent CO2 adsorption selectivity at room temperature.

    Science.gov (United States)

    Qin, Tao; Gong, Jun; Ma, Junhan; Wang, Xin; Wang, Yonghua; Xu, Yan; Shen, Xuan; Zhu, Dunru

    2014-12-28

    A water stable porous 3D metal-organic framework, [Cu3L2(μ3-OH)2(μ2-H2O)]·2DMA (1, mother crystal, H2L = 2,2'-dinitrobiphenyl-4,4'-dicarboxylic acid, DMA = N,N-dimethylacetamide), shows unprecedented irreversible solvent-induced substitutions of bridging aqua ligands and guest-exchanges in single-crystal-to-single-crystal (SCSC) transformations at room temperature (RT), producing quantitatively three daughter crystals, [Cu3L2(μ3-OH)2]·2S (2: 2A, S = acetone; 2B, S = 2-propanol; 2C, S = 2-butanol), which exhibit reversible interconversion by guest-exchanges at RT in SCSC transformations. MOF 1 shows excellent separation selectivity (128) of CO2/N2 at RT and is a better sorbent of micro-solid-phase extraction (μ-SPE) than currently known benchmark ZIF-8.

  6. Physiologically based pharmacokinetic modeling using microsoft excel and visual basic for applications.

    Science.gov (United States)

    Marino, Dale J

    2005-01-01

    Abstract Physiologically based pharmacokinetic (PBPK) models are mathematical descriptions depicting the relationship between external exposure and internal dose. These models have found great utility for interspecies extrapolation. However, specialized computer software packages, which are not widely distributed, have typically been used for model development and utilization. A few physiological models have been reported using more widely available software packages (e.g., Microsoft Excel), but these tend to include less complex processes and dose metrics. To ascertain the capability of Microsoft Excel and Visual Basis for Applications (VBA) for PBPK modeling, models for styrene, vinyl chloride, and methylene chloride were coded in Advanced Continuous Simulation Language (ACSL), Excel, and VBA, and simulation results were compared. For styrene, differences between ACSL and Excel or VBA compartment concentrations and rates of change were less than +/-7.5E-10 using the same numerical integration technique and time step. Differences using VBA fixed step or ACSL Gear's methods were generally <1.00E-03, although larger differences involving very small values were noted after exposure transitions. For vinyl chloride and methylene chloride, Excel and VBA PBPK model dose metrics differed by no more than -0.013% or -0.23%, respectively, from ACSL results. These differences are likely attributable to different step sizes rather than different numerical integration techniques. These results indicate that Microsoft Excel and VBA can be useful tools for utilizing PBPK models, and given the availability of these software programs, it is hoped that this effort will help facilitate the use and investigation of PBPK modeling.

  7. Sales Training for Army Recruiter Success: Modeling the Sales Strategies and Skills of Excellent Recruiters

    Science.gov (United States)

    1987-11-01

    strategies used by excellent Army recruiters. Neurolinguistic programming (NLP) was used as the protocol for modeling performance and acquiring...Behavioral and Social Sciences 3001 Eisenhower Avenue, Alexandria, VA 22333-5600 10. PROGRAM ELEMENT. PROJECT. TASK ARE* 4 WORK UNIT...Modeling ’Expert knowledge,, Neurolinguistics Knowledge engineering; Recruiting Sales, &’ Sales cycle Sales skills Sales strategies 20

  8. The EFQM Excellence Model: An Exploratory Attempt for Assessing the Hellenic National Sport Federations

    Directory of Open Access Journals (Sweden)

    Dimitris Karastathis

    2014-06-01

    Full Text Available The EFQM Excellence Model is an advanced tool for organizations’ improvement, which is based on the principles of the theoretical frame of Total Quality Management (Michalska, 2008. The aim of this study was a first attempt to assess the Hellenic National Sport Federations’ (HNSFs organizational-managerial operations and the investigation of their readiness degree for the application of Management Excellence’s processes, according to European Foundation of Quality Management (EFQM Excellence Model. An adaptive questionnaire, which was developed according to the managerial and functional environment of the HNSFs, was used to reflect the perception of people serving at the HNSFs about the application of quality management’s and management excellence’s practices. One hundred respondents from 18 HNSFs participated in this study. According to the results, processes of management’s excellence do exist and are indeed applied, but neither often, nor systematically. Moreover, there is a differentiation in perceptions between the three hierarchical administrative groups. It is concluded that in this particular moment a management excellence program may prove difficult to be applied in the HNSFs, unless there is common perception and agreement between the parties involved, on: a the meaning of management’s excellence and b the profits it may produce for the sport organization.

  9. Brothers in Excellence: An Empowerment Model for the Career Development of African American Boys

    Science.gov (United States)

    Grimmett, Marc A.

    2010-01-01

    The author describes Brothers in Excellence (BE), a conceptual model for understanding African American boys and helping them to be successful. BE addresses 3 domains of development proposed to be essential to the success of all African American boys: identity development, social development, and career development. (Contains 1 figure.)

  10. Towards a Multi-Stakeholder-Driven Model for Excellence in Higher Education Curriculum Development

    Science.gov (United States)

    Meyer, M. H.; Bushney, M. J.

    2008-01-01

    A multi-stakeholder-driven model for excellence in higher education curriculum development has been developed. It is based on the assumption that current efforts to curriculum development take place within a framework of limited stakeholder consultation. A total of 18 multiple stakeholders are identified, including learners, alumni, government,…

  11. The Center of Excellence Model for Information Services. CLIR Publication No. 163

    Science.gov (United States)

    Kirchner, Joy; Diaz, José; Henry, Geneva; Fliss, Susan; Culshaw, John; Gendron, Heather; Cawthorne, Jon E.

    2015-01-01

    In 2013, The Andrew W. Mellon Foundation awarded a group of seven librarians from the Research Library Leadership Fellows program of the Association of Research Libraries (ARL) a planning grant to examine the center of excellence (CoE) model for information services. Used in a variety of industries, CoEs are designed to attract the most talented…

  12. Partnership for Excellence (PFE) Evaluation Project: A Special Review of the PFE Transfer Model.

    Science.gov (United States)

    Armstrong, William

    Californias public and legislative demands over transfer performance as exemplified by the Partnerships for Excellence (PFE) Transfer model reflect a growing national trend. According to the Education Commission of the States, there has been a shift in the national mood from concern about fiscal accountability in education to one of educational…

  13. Towards a Multi-Stakeholder-Driven Model for Excellence in Higher Education Curriculum Development

    Science.gov (United States)

    Meyer, M. H.; Bushney, M. J.

    2008-01-01

    A multi-stakeholder-driven model for excellence in higher education curriculum development has been developed. It is based on the assumption that current efforts to curriculum development take place within a framework of limited stakeholder consultation. A total of 18 multiple stakeholders are identified, including learners, alumni, government,…

  14. The Center for Nursing Excellence: A Health System Model for Intentional Improvement and Innovation.

    Science.gov (United States)

    Clavelle, Joanne T; Goodwin, Miki

    2016-11-01

    An innovative Center for Nursing Excellence model that supports structural empowerment and the achievement of exemplary nursing, patient, and organizational outcomes was implemented in 2 separate health systems in the western United States. Formal leadership roles for nursing practice, research, professional education, and Magnet® continual readiness are aligned to ensure that Magnet designation is attained and maintained in system hospitals.

  15. TQM and firms performance: An EFQM excellence model research based survey

    Directory of Open Access Journals (Sweden)

    Santos-Vijande, M. L.

    2007-01-01

    Full Text Available The purpose of this article is to develop an instrument for measuring TQM implementation following the European Foundation for Quality Management Excellence Model and to provide empirical evidence on the relationship between management practices and measures of business performance in the model. To this end, the study employs survey data collected from Spanish manufacturing and service firms. Confirmatory factor analysis is used to test the psychometric properties of the measurement scales and the hypothesized relationships between total quality management practices and organizational performance are examined using structural equation modeling. The findings of the research indicate that the adoption of the TQM practices suggested in the EFQM Excellence Model allows firms to outperform their competitors in the results criteria included in the Model. Therefore, this paper provides a valuable benchmarking data for firms as it substantiates the EFQM Enabler’s contribution to the attainment of competitive advantage.

  16. Group excellence: a model for the application of Japanese management to mental health centers.

    Science.gov (United States)

    Davidson, S

    1986-01-01

    Mental health centers and other government sponsored service organizations need highly effective management techniques. In this era of tightening budgets, the Japanese Management System may be a way of increasing both excellence and employee satisfaction. Managers who choose to explore this system may need a concise, written model as a guide to the ingenious, extensive, and paradoxical Japanese Management System. The System centers around quality control circles--autonomous problem-solving groups that strive for excellence. Composed of hierarchically interlocking groups, it uses a wide selection of group cohesion techniques to inspire esprit de corps, and an interlocking set of rewards governs behavior at every level. Decision making is collective (although supervisors retain veto power), and execution of ideas, once agreed upon, is quick and consistent. The System operates holistically, enthusiastically, with a high degree of excellence and mutual concern.

  17. Developing Excellence in Gifted Children: Adaptation of Actiotope Model of Giftedness for Turkey

    Directory of Open Access Journals (Sweden)

    Marilena Z. LEANA-TASCILAR

    2014-06-01

    Full Text Available Excellence is one of the most important goals of education. It is proposed that the development of excellence be interpreted as a process of adaptation to certain environments, specifically the acquisition of functional action repertoires in talent domains. Two types of regulation are distinguished, homeostatic and allostatic regulation. There are endogenous and exogenous resources that effect education system and excellence. This provides two types of capitals the educational and the learning capital. The educational capital includes the economical and exogenous resources; while the learning capital includes endogenous resources and the characteristics that individuals have. The systemic approach is important for the development of excellence, especially for gifted students. According to systemic approach we can’t consider the gifted students independent from the environment that they live. The resources effect the development of excellence in the gifted students. Therefore, the aim of this paper is to introduce the Actiotope Model of Giftedness to the Turkish researchers and to create a new perspective for the gifted education in Turkey with underlying the importance of mentorship, parental training, self regulated learning, and planning.

  18. ShowFlow: A practical interface for groundwater modeling

    Energy Technology Data Exchange (ETDEWEB)

    Tauxe, J.D.

    1990-12-01

    ShowFlow was created to provide a user-friendly, intuitive environment for researchers and students who use computer modeling software. What traditionally has been a workplace available only to those familiar with command-line based computer systems is now within reach of almost anyone interested in the subject of modeling. In the case of this edition of ShowFlow, the user can easily experiment with simulations using the steady state gaussian plume groundwater pollutant transport model SSGPLUME, though ShowFlow can be rewritten to provide a similar interface for any computer model. Included in this thesis is all the source code for both the ShowFlow application for Microsoft{reg sign} Windows{trademark} and the SSGPLUME model, a User's Guide, and a Developer's Guide for converting ShowFlow to run other model programs. 18 refs., 13 figs.

  19. Designing Excellence and Quality Model for Training Centers of Primary Health Care: A Delphi Method Study

    Directory of Open Access Journals (Sweden)

    Jafar-Sadegh TABRIZI

    2015-10-01

    Full Text Available Background: Excellence and quality models are comprehensive methods for improving the quality of healthcare. The aim of this study was to design excellence and quality model for training centers of primary health care using Delphi method. Methods: In this study, Delphi method was used. First, comprehensive information were collected using literature review. In extracted references, 39 models were identified from 34 countries and related sub-criteria and standards were extracted from 34 models (from primary 39 models. Then primary pattern including 8 criteria, 55 sub-criteria, and 236 standards was developed as a Delphi questionnaire and evaluated in four stages by 9 specialists of health care system in Tabriz and 50 specialists from all around the country.Results: Designed primary model (8 criteria, 55 sub-criteria, and 236 standards were concluded with 8 criteria, 45 sub-criteria, and 192 standards after 4 stages of evaluations by specialists. Major criteria of the model are leadership, strategic and operational planning, resource management, information analysis, human resources management, process management, costumer results, and functional results, where the top score was assigned as 1000 by specialists. Functional results had the maximum score of 195 whereas planning had the minimum score of 60. Furthermore the most and the least sub-criteria was for leadership with 10 sub-criteria and strategic planning with 3 sub-criteria, respectively. Conclusion: The model that introduced in this research has been designed following 34 reference models of the world. This model could provide a proper frame for managers of health system in improving quality. Keywords: Quality model, Excellence model, Training centers, Primary cares, Iran

  20. Business statistics for competitive advantage with Excel 2016 basics, model building, simulation and cases

    CERN Document Server

    Fraser, Cynthia

    2016-01-01

    The revised Fourth Edition of this popular textbook is redesigned with Excel 2016 to encourage business students to develop competitive advantages for use in their future careers as decision makers. Students learn to build models using logic and experience, produce statistics using Excel 2016 with shortcuts, and translate results into implications for decision makers. The textbook features new examples and assignments on global markets, including cases featuring Chipotle and Costco. Exceptional managers know that they can create competitive advantages by basing decisions on performance response under alternative scenarios, and managers need to understand how to use statistics to create such advantages. Statistics, from basic to sophisticated models, are illustrated with examples using real data such as students will encounter in their roles as managers. A number of examples focus on business in emerging global markets with particular emphasis on emerging markets in Latin America, China, and India. Results are...

  1. AN INTEGRATED SERVICE EXCELLENCE MODEL FOR MILITARY TEST AND EVALUATION FACILITIES

    Directory of Open Access Journals (Sweden)

    Gerhard De Coning

    2011-08-01

    Full Text Available The purpose of this article is to introduce an Integrated Service Excellence Model (ISEM for empowering the leadership core of the capital-intensive military test and evaluation facilities to provide strategic military test and evaluation services and to continuously improve service excellence by ensuring that all activities necessary to design, develop and implement a test and evaluation service are effective and efficient. In order to develop the ISEM, various management tools and productivity and quality models were identified and tested through an empirical study conducted amongst the various test and evaluation facilities’ leadership core. Solutions to financial, human resource and environmental challenges as well as quality standards were built into the ISEM. Governance principles and leadership perceptions and recommendations further contributed to the development of the ISEM.

  2. Multidisciplinary Management: Model of Excellence in the Management Applied to Products and Services

    OpenAIRE

    Guerreiro, Evandro,; Costa Neto, Pedro,; Moreira Filho, Ulysses,

    2014-01-01

    Part 1: Knowledge-Based Performance Improvement; International audience; The Multidisciplinary Management is the guiding vision of modern organizations and the systems thinking which requires new approaches to organizational excellence and quality management process. The objective of this article is to present a model for multidisciplinary management of quality applied to products and services based on American, Japanese, and Brazilian National Quality Awards. The methodology used to build th...

  3. The EFQM Excellence Model: An Exploratory Attempt for Assessing the Hellenic National Sport Federations

    OpenAIRE

    Dimitris Karastathis; Υiannis Afthinos; Dimitris Gargalianos; Nicholas D Theodorakis

    2014-01-01

    The EFQM Excellence Model is an advanced tool for organizations’ improvement, which is based on the principles of the theoretical frame of Total Quality Management (Michalska, 2008). The aim of this study was a first attempt to assess the Hellenic National Sport Federations’ (HNSFs) organizational-managerial operations and the investigation of their readiness degree for the application of Management Excellence’s processes, according to European Foundation of Quality Management (EFQM) Excellen...

  4. USING THE SOUTH AFRICAN EXCELLENCE MODEL TO FOCUS IMPROVEMENT STRATEGIES IN SOUTH AFRICA.

    Directory of Open Access Journals (Sweden)

    Bruce R Smit

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: South African companies wish to join the world class family. As the Malcolm Baldrige Quality Award in the USA and the European Quality Award in Europe have been effected, the South African Quality Institute (SAQI pioneered and developed a National Quality Award together with leading South African companies. The South African Award model is a full hybrid of the Malcolm Baldrige and European Foundation Quality models. The awards process is now managed by the South African Excellence Foundation. This model enables companies to assess their excellence levels and use benchmarks towards improved quality, service and costs. The model has been ratified by the administrators of both of the aforementioned awards. The criteria in the award lend themselves to measurement by self assessment. This paper explains the model and its application as a foundation to strategic planning.

    AFRIKAANSE OPSOMMING: Maatskapye in Suid Afrika moet op die wereldmark kan presteer. Amerika het die Malcolm Baldrige Kwaliteitstoekenning en Europa die Europese Kwaliteitstoekenning.vir uitmuntende prestasie in die besigheidswereld daargestel. Die Suid Afrikaanse Kwaliteitsinstituut (SAQI het in 1997 'n Suid Afrikaanse eweknie ontwikkel. Die Suid Afrikaanse Kwaliteitstoekenning is deur die administrateurs van eersgenoemde pryse aanvaar. Die lokale Kwaliteitstoekennings word tans deur die Suid Afrikaanse Uitmuntentheidfondasie geadministreer. Die Kwaliteitstoekenning model kan gebruik word am self-meting toe te pas met die doel om besigheids prestasie te verbeter. Hierdie geskrif stel die Suid Afrikaanse model daar stel en verduidelik hoe dit vir strategiese beplanning toegepas kan word.

  5. Is there any link between accreditation programs and the models of organizational excellence?

    Directory of Open Access Journals (Sweden)

    Fernando Tobal Berssaneti

    Full Text Available Abstract OBJECTIVE To evaluate whether accredited health organizations perform better management practices than non-accredited ones. METHOD The study was developed in two stages: a literature review, and a study of multiple cases in 12 healthcare organizations in the state of São Paulo, Brazil. It surveyed articles comparing hospital accreditation with the EFQM (European Foundation for Quality Management model of excellence in management. According to the pertinent literature, the accreditation model and the EFQM model are convergent and supplementary in some aspects. RESULTS With 99% confidence, one can say that there is evidence that accredited organizations scored better in the evaluation based on the EFQM model in comparison to non-accredited organizations. This result was also confirmed in the comparison of results between the categories Facilitators and Results in the EFQM model. CONCLUSION There is convergence between the accreditation model and the EFQM excellence model, suggesting that accreditation helps the healthcare sector to implement the best management practices already used by other business sectors.

  6. Evaluation of sustainable development using business excellence model in used motor oil industries

    Directory of Open Access Journals (Sweden)

    Malek Hassanpour

    2014-10-01

    Full Text Available Business and commerce are a chance to create wealth and economic development in companies and industries. Leader of companies must be containing a sense of relief and hope as one of the factors of production and wealth to enhance trust, cooperation between the organization and the community. In order to achieve at the Business Excellence (BE is emphasized to the need for the simultaneous measurement of organizational performance on the Critical Success Factors (CSFs, environmental, social issues and challenges. Objective of current study was to evaluate of sustainable development in used motor oil industry using BE models. Therefore, a framework was discussed as distinct from other common practices to measure performance of an industry. The models allow multi -dimensional focuses on different indicators of the organization's internal, external and CSFs. The check list method was used to collect data in site of industry in the present study. Then, obtained results were surveyed by models such as the Malcolm Baldrige National Quality Award (MBNQA, European Federation for Quality Management (EFQM and Kanji’s Business Excellence Model (KBEM. Results of current analyze indicated that despite the fact that these models and approaches are different, but they are same in term of shared concepts. Finally, we can be able to say that the simultaneous implementation of these models and approaches can be a suitable process in the study of sustainable development of organizations. According to the obtained results of models, the case study industry was in sustainable development conditions.

  7. RELATIONSHIP BETWEEN ISO 9001 CERTIFICATION MATURITY AND EFQM BUSINESS EXCELLENCE MODEL RESULTS

    Directory of Open Access Journals (Sweden)

    Luis Miguel Fonseca

    2015-07-01

    Full Text Available Purpose: This exploratory research evaluates if there a relationship between the number of years since an organization has achieved ISO 9001 certification and the highest level of recognition received by the same organization with the EFQM Business Excellence Model.Methodology/Approach: After state of the art review a detailed comparison between both models was made. Fifty two Portuguese organizations were considered and Correlation coefficient Spearman Rho was used to investigate the possible relationships.Findings: Conclusion is that there is indeed a moderate positive correlation between these two variables, the higher the number of years of ISO 9001 certification, the higher the results of the organization EFQM model evaluation and recognition. This supports the assumption that ISO 9001 International Standard by incorporating many of the principles present in the EFQM Business Excellence Model is consistent with this model and can be considered as a step towards that direction.Research Limitation/implication: Due to the dynamic nature of these models that might change over time and the possible time delays between implementation and results, more in-depth studies like experimental design or a longitudinal quasi-experimental design could be used to confirm the results of this investigation.Originality/Value of paper: This research gives additional insights on conjunct studies of both models. The use of external evaluation results carried out by the independent EFQM assessors minimizes the possible bias of previous studies accessing the value of ISO 9001 certification.

  8. Reciprocal Ontological Models Show Indeterminism Comparable to Quantum Theory

    Science.gov (United States)

    Bandyopadhyay, Somshubhro; Banik, Manik; Bhattacharya, Some Sankar; Ghosh, Sibasish; Kar, Guruprasad; Mukherjee, Amit; Roy, Arup

    2016-12-01

    We show that within the class of ontological models due to Harrigan and Spekkens, those satisfying preparation-measurement reciprocity must allow indeterminism comparable to that in quantum theory. Our result implies that one can design quantum random number generator, for which it is impossible, even in principle, to construct a reciprocal deterministic model.

  9. Reciprocal Ontological Models Show Indeterminism Comparable to Quantum Theory

    Science.gov (United States)

    Bandyopadhyay, Somshubhro; Banik, Manik; Bhattacharya, Some Sankar; Ghosh, Sibasish; Kar, Guruprasad; Mukherjee, Amit; Roy, Arup

    2017-02-01

    We show that within the class of ontological models due to Harrigan and Spekkens, those satisfying preparation-measurement reciprocity must allow indeterminism comparable to that in quantum theory. Our result implies that one can design quantum random number generator, for which it is impossible, even in principle, to construct a reciprocal deterministic model.

  10. Writing Excel Macros with VBA

    CERN Document Server

    Roman, Steven

    2008-01-01

    To achieve the maximum control and flexibility from Microsoft® Excel often requires careful custom programming using the VBA (Visual Basic for Applications) language. Writing Excel Macros with VBA, 2nd Edition offers a solid introduction to writing VBA macros and programs, and will show you how to get more power at the programming level: focusing on programming languages, the Visual Basic Editor, handling code, and the Excel object model.

  11. Excel 2010 for dummies

    CERN Document Server

    Harvey, Greg

    2010-01-01

    The bestselling Excel book on the market, updated for Excel 2010 As the world's leading spreadsheet application, Excel has a huge user base. The release of Office 2010 brings major changes to Excel, so Excel For Dummies comes to the rescue once more! In the friendly and non-threatening For Dummies style, this popular guide shows beginners how to get up and running with Excel and helps more experienced users get comfortable with new features.Excel is the number one spreadsheet application worldwide, and Excel For Dummies is the number one guide to using i

  12. Is there any link between accreditation programs and the models of organizational excellence?

    Science.gov (United States)

    Berssaneti, Fernando Tobal; Saut, Ana Maria; Barakat, Májida Farid; Calarge, Felipe Araujo

    2016-01-01

    To evaluate whether accredited health organizations perform better management practices than non-accredited ones. The study was developed in two stages: a literature review, and a study of multiple cases in 12 healthcare organizations in the state of São Paulo, Brazil. It surveyed articles comparing hospital accreditation with the EFQM (European Foundation for Quality Management) model of excellence in management. According to the pertinent literature, the accreditation model and the EFQM model are convergent and supplementary in some aspects. With 99% confidence, one can say that there is evidence that accredited organizations scored better in the evaluation based on the EFQM model in comparison to non-accredited organizations. This result was also confirmed in the comparison of results between the categories Facilitators and Results in the EFQM model. There is convergence between the accreditation model and the EFQM excellence model, suggesting that accreditation helps the healthcare sector to implement the best management practices already used by other business sectors. Avaliar se as organizações de saúde acreditadas possuem melhores práticas de gestão do que as não acreditadas. A pesquisa foi dividida em duas etapas: revisão da literatura e estudo de casos múltiplos com 12 organizações de saúde, localizadas no estado de São Paulo ‒ Brasil. Foram pesquisados artigos que comparavam a acreditação hospitalar com o modelo de excelência em gestão da EFQM (European Foundation for Quality Management), sendo que a literatura pertinente considera que o modelo de acreditação e o modelo da EFQM são convergentes e, ao mesmo tempo, complementares em determinados aspectos. Com 99% de confiança, pode-se afirmar que há evidência de que as organizações com acreditação obtiveram uma pontuação maior na avaliação baseada no modelo EFQM comparativamente às organizações não acreditadas. Este resultado também se confirmou na comparação dos

  13. From representing to modelling knowledge: Proposing a two-step training for excellence in concept mapping

    Directory of Open Access Journals (Sweden)

    Joana G. Aguiar

    2017-09-01

    Full Text Available Training users in the concept mapping technique is critical for ensuring a high-quality concept map in terms of graphical structure and content accuracy. However, assessing excellence in concept mapping through structural and content features is a complex task. This paper proposes a two-step sequential training in concept mapping. The first step requires the fulfilment of low-order cognitive objectives (remember, understand and apply to facilitate novices’ development into good Cmappers by honing their knowledge representation skills. The second step requires the fulfilment of high-order cognitive objectives (analyse, evaluate and create to grow good Cmappers into excellent ones through the development of knowledge modelling skills. Based on Bloom’s revised taxonomy and cognitive load theory, this paper presents theoretical accounts to (1 identify the criteria distinguishing good and excellent concept maps, (2 inform instructional tasks for concept map elaboration and (3 propose a prototype for training users on concept mapping combining online and face-to-face activities. The proposed training application and the institutional certification are the next steps for the mature use of concept maps for educational as well as business purposes.

  14. Improving Conceptual Understanding and Representation Skills Through Excel-Based Modeling

    Science.gov (United States)

    Malone, Kathy L.; Schunn, Christian D.; Schuchardt, Anita M.

    2017-08-01

    The National Research Council framework for science education and the Next Generation Science Standards have developed a need for additional research and development of curricula that is both technologically model-based and includes engineering practices. This is especially the case for biology education. This paper describes a quasi-experimental design study to test the effectiveness of a model-based curriculum focused on the concepts of natural selection and population ecology that makes use of Excel modeling tools (Modeling Instruction in Biology with Excel, MBI-E). The curriculum revolves around the bio-engineering practice of controlling an invasive species. The study takes place in the Midwest within ten high schools teaching a regular-level introductory biology class. A post-test was designed that targeted a number of common misconceptions in both concept areas as well as representational usage. The results of a post-test demonstrate that the MBI-E students significantly outperformed the traditional classes in both natural selection and population ecology concepts, thus overcoming a number of misconceptions. In addition, implementing students made use of more multiple representations as well as demonstrating greater fascination for science.

  15. Multi-factor Analysis Model for Improving Profit Management Using Excel in Shellfish Farming Projects

    Institute of Scientific and Technical Information of China (English)

    Zhuming; ZHAO; Changlin; LIU; Xiujuan; SHAN; Jin; YU

    2013-01-01

    By using a farm’s data in Yantai City and the theory of Cost-Volume-Profit analysis and the financial management methods,this paper construct a multi-factor analysis model for improving profit management using Excel 2007 in Shellfish farming projects and describes the procedures to construct a multi-factor analysis model.The model can quickly calculate the profit,improve the level of profit management,find out the breakeven point and enhance the decision-making efficiency of businesses etc.It is also a thought of the application to offer suggestions for government decisions and economic decisions for corporations as a simple analysis tool.While effort has been exerted to construct a four-variable model,some equally important variables may not be discussed sufficiently due to limitation of the paper’s space and the authors’knowledge.All variables can be listed in EXCEL 2007 and can be associated in a logical way to manage the profit of shellfish farming projects more efficiently and more practically.

  16. Using the business excellence model to develop a strategy for a healthcare organisation.

    Science.gov (United States)

    Naylor, G

    1999-01-01

    This article examines the appropriateness of the Business Excellence Model in developing a strategy for Bolton Hospitals NHS Trust to measure organisational performance. The need for a strategy to measure organisational performance and to improve organisational performance was highlighted with the production of the Government White Paper, The New NHS: Modern and Dependable. At the heart of recommendations there is emphasis on improving quality and driving efficiency. Greater emphasis will be placed on organisations measuring their performance. By utilising the conceptual framework, which consisted of The European Foundation for Quality Management (EFQM) Model, it became evident that, although tools were in existence within Bolton Hospitals to measure organisational performance, several critical areas needed addressing. By addressing these key areas, the organisation could begin to work towards its goal of business excellence. The conclusions drawn from this project demonstrated that there was scope for Bolton Hospitals to improve on organisational performance. It was highlighted that the Trust was functioning well in some areas of the EFQM Model, but not in others. For Bolton Hospitals NHS Trust to improve organisational performance, the EFQM Model should be adopted.

  17. Excel Center

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Citigroup,one of the World top 500 companies,has now settled in Excel Center,Financial Street. The opening ceremony of Excel Center and the entry ceremony of Citigroup in the center were held on March 31.Government leaders of Xicheng District,the Excel CEO and the heads of Asia-Pacific Region leaders of Citibank all participated in the ceremony.

  18. Visual Basic, Excel-based fish population modeling tool—The pallid sturgeon example

    Science.gov (United States)

    Moran, Edward H.; Wildhaber, Mark L.; Green, Nicholas S.; Albers, Janice L.

    2016-02-10

    The model presented in this report is a spreadsheet-based model using Visual Basic for Applications within Microsoft Excel (http://dx.doi.org/10.5066/F7057D0Z) prepared in cooperation with the U.S. Army Corps of Engineers and U.S. Fish and Wildlife Service. It uses the same model structure and, initially, parameters as used by Wildhaber and others (2015) for pallid sturgeon. The difference between the model structure used for this report and that used by Wildhaber and others (2015) is that variance is not partitioned. For the model of this report, all variance is applied at the iteration and time-step levels of the model. Wildhaber and others (2015) partition variance into parameter variance (uncertainty about the value of a parameter itself) applied at the iteration level and temporal variance (uncertainty caused by random environmental fluctuations with time) applied at the time-step level. They included implicit individual variance (uncertainty caused by differences between individuals) within the time-step level.The interface developed for the model of this report is designed to allow the user the flexibility to change population model structure and parameter values and uncertainty separately for every component of the model. This flexibility makes the modeling tool potentially applicable to any fish species; however, the flexibility inherent in this modeling tool makes it possible for the user to obtain spurious outputs. The value and reliability of the model outputs are only as good as the model inputs. Using this modeling tool with improper or inaccurate parameter values, or for species for which the structure of the model is inappropriate, could lead to untenable management decisions. By facilitating fish population modeling, this modeling tool allows the user to evaluate a range of management options and implications. The goal of this modeling tool is to be a user-friendly modeling tool for developing fish population models useful to natural resource

  19. Visual Basic, Excel-based fish population modeling tool - The pallid sturgeon example

    Science.gov (United States)

    Moran, Edward H.; Wildhaber, Mark L.; Green, Nicholas S.; Albers, Janice L.

    2016-02-10

    The model presented in this report is a spreadsheet-based model using Visual Basic for Applications within Microsoft Excel (http://dx.doi.org/10.5066/F7057D0Z) prepared in cooperation with the U.S. Army Corps of Engineers and U.S. Fish and Wildlife Service. It uses the same model structure and, initially, parameters as used by Wildhaber and others (2015) for pallid sturgeon. The difference between the model structure used for this report and that used by Wildhaber and others (2015) is that variance is not partitioned. For the model of this report, all variance is applied at the iteration and time-step levels of the model. Wildhaber and others (2015) partition variance into parameter variance (uncertainty about the value of a parameter itself) applied at the iteration level and temporal variance (uncertainty caused by random environmental fluctuations with time) applied at the time-step level. They included implicit individual variance (uncertainty caused by differences between individuals) within the time-step level.The interface developed for the model of this report is designed to allow the user the flexibility to change population model structure and parameter values and uncertainty separately for every component of the model. This flexibility makes the modeling tool potentially applicable to any fish species; however, the flexibility inherent in this modeling tool makes it possible for the user to obtain spurious outputs. The value and reliability of the model outputs are only as good as the model inputs. Using this modeling tool with improper or inaccurate parameter values, or for species for which the structure of the model is inappropriate, could lead to untenable management decisions. By facilitating fish population modeling, this modeling tool allows the user to evaluate a range of management options and implications. The goal of this modeling tool is to be a user-friendly modeling tool for developing fish population models useful to natural resource

  20. A Solved Model to Show Insufficiency of Quantitative Adiabatic Condition

    Institute of Scientific and Technical Information of China (English)

    LIU Long-Jiang; LIU Yu-Zhen; TONG Dian-Min

    2009-01-01

    The adiabatic theorem is a useful tool in processing quantum systems slowly evolving,but its practical application depends on the quantitative condition expressed by Hamiltonian's eigenvalues and eigenstates,which is usually taken as a sufficient condition.Recently,the sumciency of the condition was questioned,and several counterex amples have been reported.Here we present a new solved model to show the insufficiency of the traditional quantitative adiabatic condition.

  1. Business performance assessment and the EFQM Excellence Model 2010 (case study

    Directory of Open Access Journals (Sweden)

    Mária Antošová

    2015-01-01

    Full Text Available The application of the latest management methods becomes today, during the ongoing European integration processes, a requisite for the success of the business within the environment of international markets. In this paper, the authors pay attention to the expansion of the organizational knowledge base with an application of a new management method. They are dealing with assessment of the organization performance, the issue of its effectiveness and the increasing economic efficiency, on an example of a selected mining company as a case study. In order to detect weaknesses in the company reviewed and to offer suggestions for improvement, which may move the company towards prosperity, the authors carried out the performance assessment by using the EFQM Excellence Model 2010. The aim of this paper is to introduce the business performance assessment model in terms of the European standards that will allow the use of latest management methods in the environment of both the Slovak and European companies.

  2. Development of the ECLSS Sizing Analysis Tool and ARS Mass Balance Model Using Microsoft Excel

    Science.gov (United States)

    McGlothlin, E. P.; Yeh, H. Y.; Lin, C. H.

    1999-01-01

    The development of a Microsoft Excel-compatible Environmental Control and Life Support System (ECLSS) sizing analysis "tool" for conceptual design of Mars human exploration missions makes it possible for a user to choose a certain technology in the corresponding subsystem. This tool estimates the mass, volume, and power requirements of every technology in a subsystem and the system as a whole. Furthermore, to verify that a design sized by the ECLSS Sizing Tool meets the mission requirements and integrates properly, mass balance models that solve for component throughputs of such ECLSS systems as the Water Recovery System (WRS) and Air Revitalization System (ARS) must be developed. The ARS Mass Balance Model will be discussed in this paper.

  3. A Dynamic Network Model to Explain the Development of Excellent Human Performance

    NARCIS (Netherlands)

    Den Hartigh, Ruud J.R.; Van Dijk, Marijn W.G.; Steenbeek, Henderien W.; Van Geert, Paul L.C.

    2016-01-01

    Across different domains, from sports to science, some individuals accomplish excellent levels of performance. For over 150 years, researchers have debated the roles of specific nature and nurture components to develop excellence. In this article, we argue that the key to excellence does not reside

  4. A Dynamic Network Model to Explain the Development of Excellent Human Performance

    NARCIS (Netherlands)

    Den Hartigh, Ruud J.R.; Van Dijk, Marijn W.G.; Steenbeek, Henderien W.; Van Geert, Paul L.C.

    2016-01-01

    Across different domains, from sports to science, some individuals accomplish excellent levels of performance. For over 150 years, researchers have debated the roles of specific nature and nurture components to develop excellence. In this article, we argue that the key to excellence does not reside

  5. Excellence in cost-effective inpatient specialist palliative care in the NHS - a new model.

    Science.gov (United States)

    Grogan, Eleanor; Paes, Paul; Peel, Tim

    2016-02-01

    There is little in the literature describing hospital specialist palliative care units (PCUs) within the NHS. This paper describes how specialist PCUs can be set up within and be entirely funded by the NHS, and outlines some of the challenges and successes of the units. Having PCUs within hospitals has offered patients increased choice over their place of care and death; perhaps not surprisingly leading to a reduced death rate in the acute hospital. However, since the opening of the PCUs there has also been an increased home death rate. The PCUs are well received by patients, families and other staff within the hospital. We believe they offer a model for excellence in cost-effective inpatient specialist palliative care within the NHS.

  6. [Strive for excellence and addiction to body movement: a risk model in high-level athletes].

    Science.gov (United States)

    Carrier, C

    2000-04-01

    Champion athletes strive to attain a personal goal defined by a socially constructed image of psychomotor performance to be accomplished at the moment of the championship celebration. This intrapsychic process is initiated by a transformation of the body, programmed and controlled by repeated training. The athlete's body becomes accustomed to ritualized obsessive movements, favoring the feeling of self-fulfillment solely during muscular effort (contraction/relaxation, displacement). This social goal of excellence implies personal adaptation involving an addictive link to movement: a mechanism uniquely valid in high level sports. Twelve years experience in psychological support of high-level athletes participating in Olympic sports has led to an analysis of this adaptive mechanism and a proposed psychopathological model of its invasion of the athlete's psychic economy.

  7. Performance Evaluation of Sadoghi Hospital Based on «EFQM» Organizational Excellence Model

    Directory of Open Access Journals (Sweden)

    A Sanayeei

    2013-04-01

    Full Text Available Introduction: Realm of health care that organizations have faced in recent years has been described with high level of dynamism and development. To survive in such conditions, performance evaluation can have an effective role in satisfying proper quality for services. This study aimed to evaluate the performance of Shahid Sadoghi Yazd hospital through EFQM approach. Methods: This was a descriptive cross-sectional study. Data collection instrument was EFQM organization Excellence Model questionnaire which was completed by all the managers. The research data was gathered from a sample of 302 patients, staff, personnel and medical staff working in different parts of the hospital. Random stratified samples were selected and descriptive statistics were utilized in order to analyze the data. Results: The results revealed that Shahid Sadoughi hospital acquired 185.41 points out of the total 500 points considered in the model EFQM. In other words, the rating reflects the fact that regarding the defined desired position, the hospital has not achieved the desired rating. Conclusion: Since the hospital performance is posited in a low-middle class, much more attention is required in regard to therapeutic management in this hospital. Therefore, codifying an efficient and effective program to improve the hospital performance is necessary. Furthermore, it seems that EFQM model can be considered as a comprehensive model for performance evaluation in hospitals.

  8. Defining excellence.

    Science.gov (United States)

    Mehl, B

    1993-05-01

    Excellence in the pharmacy profession, particularly pharmacy management, is defined. Several factors have a significant effect on the ability to reach a given level of excellence. The first is the economic and political climate in which pharmacists practice. Stricter controls, reduced resources, and the velocity of change all necessitate nurturing of values and a work ethic to maintain excellence. Excellence must be measured by the services provided with regard to the resources available; thus, the ability to achieve excellence is a true test of leadership and innovation. Excellence is also time dependent, and today's innovation becomes tomorrow's standard. Programs that raise the level of patient care, not those that aggrandize the profession, are the most important. In addition, basic services must be practiced at a level of excellence. Quality assessment is a way to improve care and bring medical treatment to a higher plane of excellence. For such assessment to be effective and not punitive, the philosophy of the program must be known, and the goal must be clear. Excellence in practice is dependent on factors such as political and social norms, standards of practice, available resources; perceptions, time, the motivation to progress to a higher level, and the continuous innovation required to reshape the profession to meet the needs of society.

  9. Lumpy - an interactive Lumped Parameter Modeling code based on MS Access and MS Excel.

    Science.gov (United States)

    Suckow, A.

    2012-04-01

    areas. For a user defined choice of up to five parameters (mean residence times and dispersion parameters of the two sub-LPM plus the mixing ratios of the two models) the best fit can be determined. Fits can be assessed using different methods for the Goodness Of Fit. Input and output data are send to MS Excel for interactive display of modeling result and comparison with measurements. Excel only serves as data display; computations are performed in AB throughout. Lumpy allows display of time series and any combination of tracer vs. tracer plot. In the latter, the possible output data space assessable by the input variables can be displayed, to check if any of the model combinations under consideration is able to explain the measured data. Comparison and fit to measurements is possible after each of the two sub-models and after mixing these two. The talk will demonstrate the usefulness of this approach with examples from the Croatian Karst (Babinka 2007), the Fischa tracer test (Stolp et al., 2010) and the 30 years monthly tritium time series of the Danube (Aggarwal et al., 2010).

  10. APPLYING THE EFQM EXCELLENCE MODEL AT THE GERMAN STUDY LINE WITH FOCUS ON THE CRITERION

    Directory of Open Access Journals (Sweden)

    ILIES LIVIU

    2013-07-01

    Full Text Available This article presents a stage of the implementation process of the EFQM Model in a higher education institution, namely at the German study line within the Faculty of Economics and Business Administration, “Babeș - Bolyai” University, Cluj –Napoca. Actually, designing this model for the higher education sector means highlighting the basis for the implementation of a Total Quality Management model, seen as a holistic dimension for the perception of quality in an organization. By means of the EFQM method, the authors try to identify the performance degree of the criterion ,,Customer Results”, related to the students’ satisfaction level. The students are seen as primary customers of the higher education sector and have an essential role in defining the quality dimensions. On the one hand, the customers of the higher education sector can surface the status quo of the quality in the institution and on the other hand they can improve the quality. Actually, the continuous improvement of quality is highly linked to performance. From this point of view, the European Foundation for Quality Management model is a practical tool in order to support the analysis of the opportunities within higher education institutions. Therefore, this model offers a customer focused approach, because many higher education institutions consider the students to be the heart of teaching and researching. Further, the fundamental concepts are defined and the focus is pointed in the direction of customer approach, which highlight the idea that excellence is creating added value for customers. Anticipating and identifying the current and the future needs of the students by developing a balanced range of relevant dimensions and indicators means taking an appropriate action based on the holistic view of quality in an organization. Focusing and understanding students’ and other customers’ requirements, their needs and expectations, follows the idea that performance can

  11. APPLICATION OF ISO 9001 AND EFQM EXCELLENCE MODEL WITHIN HIGHER EDUCATION INSTITUTIONS: PRACTICAL EXPERIENCES ANALYSIS

    Directory of Open Access Journals (Sweden)

    Ramune Kasperaviciute

    2013-06-01

    Full Text Available Purpose – to systemise and analyse practical experiences of the application of the EFQM Excellence Model (EM and ISO 9001 standard within Higher education institutions (HEIs. There is an aim to understand: 1 what are the main motives of the application of the analysed quality management (QM means within academic institutions; 2 what are the most common issues occurring during the implementation; 3 what are the most common benefits. Design/methodology/approach – practical experiences of HEIs from various countries are analysed and the data from 30 case studies (17 case studies focus on experiences applying ISO 9001 standard for quality management system (QMS development and 13 case studies focus on experiences implementing EFQM EM summarized. The sample of the research was formed after review of relevant scientific researches between 1995 and 2013 available in EBSCO, Emerald Management Journal Collection, ProQuest, JSTOR, Sage Publications: Sage Journal Online databases. Selection criteria of case studies was application of ISO 9001 and EFQM EM in HEIs from various countries. Research methods: systematic scientific literature analysis, content analysis. Findings – the research revealed that the main motives of HEIs to apply ISO 9001 and the EFQM EM are related the most common to internal institutional needs, competitiveness in the market and requirements of the stakeholders. 18 fundamental issues of the application of the means were identified which are more often related to institutional problems than to standard/model issues. The implementation of both means within academic institutions conditioned the benefits linked with internal institutional changes. The most significant general benefits are related to the goals of the means and cultural changes of the institution. Research limitations/implications – case studies publicised in English and Lithuanian languages only were analysed in the article. The inclusion of available researches

  12. Trends in Education Excellence Gaps: A 12-Year International Perspective via the Multilevel Model for Change

    Science.gov (United States)

    Rutkowski, David; Rutkowski, Leslie; Plucker, Jonathan A.

    2012-01-01

    A recent study in the USA documented the existence and growth of "excellence gaps" among students. These gaps are similar to the minimum competency achievement gaps that proliferate in policy discussions in many Western countries, but excellence gaps focus on the highest level of achievement rather than minimum competency. We extend this…

  13. Trends in Education Excellence Gaps: A 12-Year International Perspective via the Multilevel Model for Change

    Science.gov (United States)

    Rutkowski, David; Rutkowski, Leslie; Plucker, Jonathan A.

    2012-01-01

    A recent study in the USA documented the existence and growth of "excellence gaps" among students. These gaps are similar to the minimum competency achievement gaps that proliferate in policy discussions in many Western countries, but excellence gaps focus on the highest level of achievement rather than minimum competency. We extend this…

  14. Showing that the race model inequality is not violated

    DEFF Research Database (Denmark)

    Gondan, Matthias; Riehl, Verena; Blurton, Steven Paul

    2012-01-01

    important being race models and coactivation models. Redundancy gains consistent with the race model have an upper limit, however, which is given by the well-known race model inequality (Miller, 1982). A number of statistical tests have been proposed for testing the race model inequality in single...... participants and groups of participants. All of these tests use the race model as the null hypothesis, and rejection of the null hypothesis is considered evidence in favor of coactivation. We introduce a statistical test in which the race model prediction is the alternative hypothesis. This test controls...

  15. Excellent approach to modeling urban expansion by fuzzy cellular automata: agent base model

    Science.gov (United States)

    Khajavigodellou, Yousef; Alesheikh, Ali A.; Mohammed, Abdulrazak A. S.; Chapi, Kamran

    2014-09-01

    Recently, the interaction between humans and their environment is the one of important challenges in the world. Landuse/ cover change (LUCC) is a complex process that includes actors and factors at different social and spatial levels. The complexity and dynamics of urban systems make the applicable practice of urban modeling very difficult. With the increased computational power and the greater availability of spatial data, micro-simulation such as the agent based and cellular automata simulation methods, has been developed by geographers, planners, and scholars, and it has shown great potential for representing and simulating the complexity of the dynamic processes involved in urban growth and land use change. This paper presents Fuzzy Cellular Automata in Geospatial Information System and remote Sensing to simulated and predicted urban expansion pattern. These FCA-based dynamic spatial urban models provide an improved ability to forecast and assess future urban growth and to create planning scenarios, allowing us to explore the potential impacts of simulations that correspond to urban planning and management policies. A fuzzy inference guided cellular automata approach. Semantic or linguistic knowledge on Land use change is expressed as fuzzy rules, based on which fuzzy inference is applied to determine the urban development potential for each pixel. The model integrates an ABM (agent-based model) and FCA (Fuzzy Cellular Automata) to investigate a complex decision-making process and future urban dynamic processes. Based on this model rapid development and green land protection under the influences of the behaviors and decision modes of regional authority agents, real estate developer agents, resident agents and non- resident agents and their interactions have been applied to predict the future development patterns of the Erbil metropolitan region.

  16. Showing that the race model inequality is not violated

    DEFF Research Database (Denmark)

    Gondan, Matthias; Riehl, Verena; Blurton, Steven Paul

    2012-01-01

    important being race models and coactivation models. Redundancy gains consistent with the race model have an upper limit, however, which is given by the well-known race model inequality (Miller, 1982). A number of statistical tests have been proposed for testing the race model inequality in single...... participants and groups of participants. All of these tests use the race model as the null hypothesis, and rejection of the null hypothesis is considered evidence in favor of coactivation. We introduce a statistical test in which the race model prediction is the alternative hypothesis. This test controls...... the Type I error if a theory predicts that the race model prediction holds in a given experimental condition. © 2011 Psychonomic Society, Inc....

  17. Showing that the race model inequality is not violated

    DEFF Research Database (Denmark)

    Gondan, Matthias; Riehl, Verena; Blurton, Steven Paul

    2012-01-01

    important being race models and coactivation models. Redundancy gains consistent with the race model have an upper limit, however, which is given by the well-known race model inequality (Miller, 1982). A number of statistical tests have been proposed for testing the race model inequality in single...... participants and groups of participants. All of these tests use the race model as the null hypothesis, and rejection of the null hypothesis is considered evidence in favor of coactivation. We introduce a statistical test in which the race model prediction is the alternative hypothesis. This test controls...... the Type I error if a theory predicts that the race model prediction holds in a given experimental condition. © 2011 Psychonomic Society, Inc....

  18. From research excellence to brand relevance: A model for higher education reputation building

    Directory of Open Access Journals (Sweden)

    Nina Overton-de Klerk

    2016-05-01

    Full Text Available In this article we propose a novel approach to reputation development at higher education institutions. Global reputation development at higher education institutions is largely driven by research excellence, is predominantly measured by research output, and is predominantly reflected in hierarchical university rankings. The ranking becomes equated with brand equity. We argue that the current approach to reputation development in higher education institutions is modernist and linear. This is strangely out-of-kilter with the complexities of a transforming society in flux, the demands of a diversity of stakeholders, and the drive towards transdisciplinarity, laterality, reflexivity and relevance in science. Good research clearly remains an important ingredient of a university's brand value. However, a case can be made for brand relevance, co-created in collaboration with stakeholders, as an alternative and non-linear way of differentiation. This approach is appropriate in light of challenges in strategic science globally as well as trends and shifts in the emerging paradigm of strategic communication. In applying strategic communication principles to current trends and issues in strategic science and the communication thereof, an alternative model for strategic reputation building at higher education institutions is developed.

  19. Conceptualizing strategic business model innovation leadership for business survival and business model innovation excellence

    DEFF Research Database (Denmark)

    Lindgren, Peter; Abdullah, Maizura Ailin

    2013-01-01

    Too many businesses are being marginalized by blind "business model innovations (BMIs)" and simple "BMIs". As documented in previous research (Markides 2008, Lindgren 2012), most businesses perform BMIs at a reactive level i.e. perceiving what the market, customers and network partners might want...... rather than what they actually demand. Few businesses have the ability to proactively lead BMIs and on a strategic level lead BMIs to something that fits the business’s long term perspective (Hamel 2011). Apple, Ryanair, Facebook, Zappo are some businesses that have shown BMI Leadership (BMIL......) in a proactive way - and more importantly, as some examples of first level BMIL. The overall aim of the BMIL is to prevent businesses from being marginalized by the BMI and thereby to optimize the business’s total BMI investment. The literature research and case research we studied gave us some important...

  20. Conceptualizing strategic business model innovation leadership for business survival and business model innovation excellence

    DEFF Research Database (Denmark)

    Lindgren, Peter; Abdullah, Maizura Ailin

    2013-01-01

    Too many businesses are being marginalized by blind "business model innovations (BMIs)" and simple "BMIs". As documented in previous research (Markides 2008, Lindgren 2012), most businesses perform BMIs at a reactive level i.e. perceiving what the market, customers and network partners might want...... rather than what they actually demand. Few businesses have the ability to proactively lead BMIs and on a strategic level lead BMIs to something that fits the business’s long term perspective (Hamel 2011). Apple, Ryanair, Facebook, Zappo are some businesses that have shown BMI Leadership (BMIL......) in a proactive way - and more importantly, as some examples of first level BMIL. The overall aim of the BMIL is to prevent businesses from being marginalized by the BMI and thereby to optimize the business’s total BMI investment. The literature research and case research we studied gave us some important...

  1. Showing Automatically Generated Students' Conceptual Models to Students and Teachers

    Science.gov (United States)

    Perez-Marin, Diana; Pascual-Nieto, Ismael

    2010-01-01

    A student conceptual model can be defined as a set of interconnected concepts associated with an estimation value that indicates how well these concepts are used by the students. It can model just one student or a group of students, and can be represented as a concept map, conceptual diagram or one of several other knowledge representation…

  2. Collaborative Workshops and Student Academic Performance in Introductory College Mathematics Courses: A Study of a Treisman Model Math Excel Program.

    Science.gov (United States)

    Duncan, Hollis; Dick, Thomas

    2000-01-01

    Describes the Treisman model which involves supplemental workshops in which college students solve problems in collaborative learning groups. Reports on the effectiveness of Math Excel, an implementation of the Treisman model for introductory mathematics courses at Oregon State University over five academic terms. Reveals a significant effect on…

  3. Master VISUALLY Excel 2010

    CERN Document Server

    Marmel, Elaine

    2010-01-01

    The complete visual reference on Excel basics. Aimed at visual learners who are seeking an all-in-one reference that provides in-depth coveage of Excel from a visual viewpoint, this resource delves into all the newest features of Excel 2010. You'll explore Excel with helpful step-by-step instructions that show you, rather than tell you, how to navigate Excel, work with PivotTables and PivotCharts, use macros to streamline work, and collaborate with other users in one document.: This two-color guide features screen shots with specific, numbered instructions so you can learn the actions you need

  4. Excel 2010 Made Simple

    CERN Document Server

    Katz, Abbott

    2011-01-01

    Get the most out of Excel 2010 with Excel 2010 Made Simple - learn the key features, understand what's new, and utilize dozens of time-saving tips and tricks to get your job done. Over 500 screen visuals and clear-cut instructions guide you through the features of Excel 2010, from formulas and charts to navigating around a worksheet and understanding Visual Basic for Applications (VBA) and macros. Excel 2010 Made Simple takes a practical and highly effective approach to using Excel 2010, showing you the best way to complete your most common spreadsheet tasks. You'll learn how to input, format,

  5. Excel 2013 formulas

    CERN Document Server

    Walkenbach, John

    2013-01-01

    Maximize the power of Excel 2013 formulas with this must-have Excel reference John Walkenbach, known as ""Mr. Spreadsheet,"" is a master at deciphering complex technical topics and Excel formulas are no exception. This fully updated book delivers more than 800 pages of Excel 2013 tips, tricks, and techniques for creating formulas that calculate, developing custom worksheet functions with VBA, debugging formulas, and much more. Demonstrates how to use all the latest features in Excel 2013 Shows how to create financial formulas and tap into the power of array formulas

  6. Towards excellence in asthma management (TEAM): a populational disease-management model.

    Science.gov (United States)

    Boulet, Louis-Philippe; Thivierge, Robert L; Amesse, André; Nunes, Fatima; Francoeur, Suzanne; Collet, Jean-Paul

    2002-06-01

    Asthma management is not always optimal, and deficiencies such as inadequate treatment and insufficient patient education are often reported. Towards Excellence in Asthma Management (TEAM) is a four-phase disease management program of the Quebec Asthma Education Network (QAEN), to be carried out over a 5-year period. The program aims to achieve a continuous improvement of asthma management by caregivers and patients. The first phase, completed in January 2000, consisted of determining the actual level of asthma-associated morbidity and mortality in various Quebec regions. The second phase, which began in September 1999, included three parts: 1. Definition of the burden of asthma, taking into account the socioeconomic consequences of the disease and the quality of life of the patients, 2. Comparison of current medical practices with the Canadian Asthma Consensus Guidelines for adult and pediatric populations, 3. Evaluation of the level of compliance with medical treatment and with the environmental changes recommended to asthmatic patients. This phase is carried out via a cohort study of physicians, mainly general practitioners and pediatricians, generating a patient cohort study, in addition to substudies evaluating specific aspects of asthma care. Once the care gap is identified, it will be possible to define, apply, and evaluate a series of interventions for physicians, other health professionals, and patients. The interventions will be particularly targeted at regions where asthma incidence and morbidity are higher. We hope that this model of disease management will progressively reduce the burden associated with asthma, and potentially other chronic diseases, and will result in the more effective use of health services.

  7. Why Excel?

    Science.gov (United States)

    Barreto, Humberto

    2015-01-01

    This article is not the usual Excel pedagogy fare in that it does not provide an application or example taught via a spreadsheet. Instead, it briefly reviews the history of spreadsheets in the economics classroom and explores the current environment, with an emphasis on modern learning theory. The conclusion is not surprising: spreadsheets improve…

  8. Sourcing Excellence

    DEFF Research Database (Denmark)

    Adeyemi, Oluseyi

    2011-01-01

    Sourcing Excellence is one of the key performance indicators (KPIs) in this world of ever changing sourcing strategies. Manufacturing companies need to access and diagnose the reliability and competencies of existing suppliers in order to coordinate and develop them. This would help in managing...

  9. Excellence in Business Education (A "FRUCE" Model for Higher Education Commission-Recognized Business Schools in Pakistan)

    Science.gov (United States)

    Kolachi, Nadir Ali; Mohammad, Jan

    2013-01-01

    The paper develops a new model of the essential factors required to be a top business school in the world for the benefit of schools recognized by the Higher Education Commission (HEC) in Pakistan. Globally, top business schools are those that excel in research, attract strong faculty, and successfully foster student development. The present…

  10. ETV TEST REPORT OF CONTROL OF BIOAEROSOLS IN HVAC SYSTEMS GLASFLOSS INDUSTRIES EXCEL FILTER, MODEL SBG24242898

    Science.gov (United States)

    The Environmental Technology Verification report discusses the technology and performance of the Excel Filter, Model SBG24242898 air filter for dust and bioaerosol filtration manufactured by Glasfloss Industries, Inc. The pressure drop across the filter was 82 Pa clean and 348 Pa...

  11. Apfel's excellent match

    Science.gov (United States)

    1997-01-01

    Apfel's excellent match: This series of photos shows a water drop containing a surfactant (Triton-100) as it experiences a complete cycle of superoscillation on U.S. Microgravity Lab-2 (USML-2; October 1995). The time in seconds appears under the photos. The figures above the photos are the oscillation shapes predicted by a numerical model. The time shown with the predictions is nondimensional. Robert Apfel (Yale University) used the Drop Physics Module on USML-2 to explore the effect of surfactants on liquid drops. Apfel's research of surfactants may contribute to improvements in a variety of industrial processes, including oil recovery and environmental cleanup.

  12. SUPERPOSE-An excel visual basic program for fracture modeling based on the stress superposition method

    Science.gov (United States)

    Ismail Ozkaya, Sait

    2014-03-01

    An Excel Visual Basic program, SUPERPOSE, is presented to predict the distribution, relative size and strike of tensile and shear fractures on anticlinal structures. The program is based on the concept of stress superposition; addition of curvature-related local tensile stress and regional far-field stress. The method accurately predicts fractures on many Middle East Oil Fields that were formed under a strike slip regime as duplexes, flower structures or inverted structures. The program operates on the Excel platform. The program reads the parameters and structural grid data from an Excel template and writes the results to the same template. The program has two routines to import structural grid data in the Eclipse and Zmap formats. The platform of SUPERPOSE is a single layer structural grid of a given cell size (e.g. 50×50 m). In the final output, a single tensile or two conjugate shear fractures are placed in each cell if fracturing criteria are satisfied; otherwise the cell is left blank. Strike of the representative fracture(s) is calculated and exact, but the length is an index of fracture porosity (fracture density×length×aperture) within that cell.

  13. Excel 2010 bible

    CERN Document Server

    Walkenbach, John

    2010-01-01

    A comprehensive reference to the newest version of the world's most popular spreadsheet application: Excel 2010 John Walkenbach's name is synonymous with excellence in computer books that decipher complex technical topics. Known as ""Mr. Spreadsheet,"" Walkenbach shows you how to maximize the power of all the new features of Excel 2010. An authoritative reference, this perennial bestseller proves itself indispensable no matter your level of skill, from Excel beginners and intermediate users to power users and potential power users everywhere. Fully updated for the new release, this

  14. DEVELOPMENT OF RIVER FLOOD ROUTING MODEL USING NON-LINEAR MUSKINGUM EQUATION AND EXCEL TOOL 'GANetXL'

    Directory of Open Access Journals (Sweden)

    Briti Sundar Sil

    2016-01-01

    Full Text Available Flood routing is of utmost importance to water resources engineers and hydrologist. Muskingum model is one of the popular methods for river flood routing which often require a huge computational work. To solve the routing parameters, most of the established methods require knowledge about different computer programmes and sophisticated models. So, it is beneficial to have a tool which is comfortable to users having more knowledge about everyday decision making problems rather than the development of computational models as the programmes. The use of micro-soft excel and its relevant tool like solver by the practicing engineers for normal modeling tasks has become common over the last few decades. In excel environment, tools are based on graphical user interface which are very comfortable for the users for handling database, modeling, data analysis and programming. GANetXL is an add-in for Microsoft Excel, a leading commercial spreadsheet application for Windows and MAC operating systems. GANetXL is a program that uses a Genetic Algorithm to solve a wide range of single and multi-objective problems. In this study, non-linear Muskingum routing parameters are solved using GANetXL. Statistical Model performances are compared with the earlier results and found satisfactory.

  15. Sourcing Excellence

    DEFF Research Database (Denmark)

    Adeyemi, Oluseyi

    2011-01-01

    Sourcing Excellence is one of the key performance indicators (KPIs) in this world of ever changing sourcing strategies. Manufacturing companies need to access and diagnose the reliability and competencies of existing suppliers in order to coordinate and develop them. This would help in managing...... in manufacturing companies. In addition, an advanced approach to sourcing involves integrating and coordinating suppliers, common materials, processes, designs and technologies across worldwide buying, design and operating locations. However, since most manufacturing companies do not have well-developed suppliers...... for global sourcing strategies in place, improvement opportunities in this area are attractive and as yet largely unrealized. Shifting from a narrow, cost-reduction emphasis with suppliers to an emphasis on globally integrated and coordinated sourcing strategies with well-developed suppliers would improve...

  16. TQM AND BUSINESS EXCELLENCE

    Directory of Open Access Journals (Sweden)

    ANDREEA IONICĂ

    2010-01-01

    Full Text Available Our paper discuss the „hot” topic of Business Excellence (BE aiming to highlight and clarify the connections with Total Quality Management (TQM. Thus, we describe the quality movement from inspection to statistical quality control and the „Japanese Age” of quality followed then by Total Quality Control (TQC and TQM developments that drived to the models of BE. After that, we present some perspectives of defining the excellence at national and international level and an overview of BE models with focus on the referential ones. Finally, we attempt to sketch the coordinates of the "journey" through TQM towards excellence in Romania.

  17. An exercise to teach quantitative analysis and modeling using Excel-based analysis of the carbon cycle in the anthropocene

    Science.gov (United States)

    Stoll, Heather

    2013-04-01

    A computer modeling exercise was created to allows students to investigate the consequences of fossil fuel burning and land use change on the amount of carbon dioxide in the atmosphere. Students work with a simple numerical model of the carbon cycle which is rendered in Excel, and conduct a set of different sensitivity tests with different amounts and rate of C additions, and then graph and discuss their results. In the recommended approach, the model is provided to students without the biosphere and in class the formulas to integrate this module are typed into Excel simultaneously by instructor and students, helping students understand how the larger model is set up. In terms of content, students learn to recognize the redistribution of fossil fuel carbon between the ocean and atmosphere, and distinguish the consequences of rapid vs slow rates of addition of fossil fuel CO2 and the reasons for this difference. Students become familiar with the use of formulas in Excel and working with a large (300 rows, 20 columns) worksheet and gain competence in graphical representation of multiple scenarios. Students learn to appreciate the power and limitations of numerical models of complex cycles, the concept of inverse and forward models, and sensitivity tests. Finally, students learn that a reasonable hypothesis, may be "reasonable" but still not quantitatively sufficient - in this case, that the "Industrial Revolution" was not the source of increasing atmospheric CO2 from 1750-1900. The described activity is available to educators on the Teach the Earth portal of the Science Education Research Center (SERC) http://serc.carleton.edu/quantskills/activities/68751.html.

  18. From the model of integral attention to the creation of centers of excellence in rheumatoid arthritis.

    Science.gov (United States)

    Santos-Moreno, Pedro; Castañeda, Oswaldo; Garro, Boris; Flores, Dennis; Sánchez, Guillermo; Castro, Carlos

    2015-03-01

    For the Pan American Health Organization (PAHO), the care of patients with chronic diseases currently experiences fragmentation in attention, generating poor performance of health services. Thus, comprehensive health care strategies arise to mitigate these problems; one of them are Centers of Excellence (CoEs), which aim to obtain high quality results in health from the adequate and minimum use of resources. The objective of this study was to describe the history and current context of the CoE in comprehensive care in patients with rheumatoid arthritis (RA). A systematic search of the literature terms (MeSH) was performed. The bases used were PubMed, Ebsco Host, Lilacs, Science Direct, Ovid, and Google (gray literature). The source of the information was evaluated to determine its quality. International standards focus the CoEs starting from comprehensive management of patients with RA and patient volume, continuous improvement, and quality of health care, constituting an interdisciplinary team. The REAL-PANLAR group suggested that the inclusion of the strategy "Treat to Target", and patient education improves patient conditions and understanding of the disease. RA is a prevalent and costly disease. The creation of comprehensive care centers of the CoE type is an initiative that improves the prognosis of RA. This document aims to encourage rheumatologists and scientific societies to structure CoE in an interdisciplinary endeavor.

  19. Applications of Excel to the mathematics modeling teaching%Excel在数学建模教学中的应用

    Institute of Scientific and Technical Information of China (English)

    赵伟斌

    2009-01-01

    This paper focuses on the mathematics modeling teaching. Since AHP method is widely used in object decision problem, a new way different from traditional method adapting simple office software Excel is explored. Excel's statistics analysis kit can offer a fast, effective and direct solving method to such problem.%本文从数学建模课程教学方面进行尝试,针对数学建模目标决策分析中应用广泛的层次分析法,改变传统教学模式,利用常规、简单的Excel软件中的统计分析功能,探寻求解此类数学问题的快速、有效、直接的方法.

  20. People management as indicator of business excellence

    DEFF Research Database (Denmark)

    Haffer, Rafal; Kristensen, Kai

    2010-01-01

    Purpose – This paper aims to show the importance of people management as a key indicator of business excellence based on four research projects, conducted on the samples of Polish (in the years 2004-2005 and 2006-2007) and Danish companies (in 1999 and 2005). Design/methodology/approach – EFQM...... it possible to compare developing Polish and developed Danish companies in their initiatives aiming at business excellence. Findings – The results indicate significant negligence in the management of human resources as one of the initiatives towards business excellence of Polish enterprises before Poland...... Excellence Model indicators were used as the evaluation criteria for the studies. The data were next estimated as a structural equation model by partial least squares using SmartPLS software. That estimation was conducted on the model of the Danish Business Excellence Index methodology. Presented data make...

  1. Clinical Scholar Model: providing excellence in clinical supervision of nursing students.

    Science.gov (United States)

    Preheim, Gayle; Casey, Kathy; Krugman, Mary

    2006-01-01

    The Clinical Scholar Model (CSM) is a practice-education partnership focused on improving the outcomes of clinical nursing education by bridging the academic and service settings. An expert clinical nurse serves as a clinical scholar (CS) to coordinate, supervise, and evaluate the clinical education of nursing students in collaboration with school of nursing faculty. This article describes the model's evolution, how the model is differentiated from traditional clinical instruction roles and responsibilities, and the benefits to the collaborating clinical agency and school of nursing.

  2. Development of a Microsoft Excel tool for one-parameter Rasch model of continuous items: an application to a safety attitude survey

    Directory of Open Access Journals (Sweden)

    Tsair-Wei Chien

    2017-01-01

    Full Text Available Abstract Background Many continuous item responses (CIRs are encountered in healthcare settings, but no one uses item response theory’s (IRT probabilistic modeling to present graphical presentations for interpreting CIR results. A computer module that is programmed to deal with CIRs is required. To present a computer module, validate it, and verify its usefulness in dealing with CIR data, and then to apply the model to real healthcare data in order to show how the CIR that can be applied to healthcare settings with an example regarding a safety attitude survey. Methods Using Microsoft Excel VBA (Visual Basic for Applications, we designed a computer module that minimizes the residuals and calculates model’s expected scores according to person responses across items. Rasch models based on a Wright map and on KIDMAP were demonstrated to interpret results of the safety attitude survey. Results The author-made CIR module yielded OUTFIT mean square (MNSQ and person measures equivalent to those yielded by professional Rasch Winsteps software. The probabilistic modeling of the CIR module provides messages that are much more valuable to users and show the CIR advantage over classic test theory. Conclusions Because of advances in computer technology, healthcare users who are familiar to MS Excel can easily apply the study CIR module to deal with continuous variables to benefit comparisons of data with a logistic distribution and model fit statistics.

  3. Achieveing Organizational Excellence Through

    Directory of Open Access Journals (Sweden)

    Mehdi Abzari

    2009-04-01

    Full Text Available AbstractToday, In order to create motivation and desirable behavior in employees, to obtain organizational goals,to increase human resources productivity and finally to achieve organizational excellence, top managers oforganizations apply new and effective strategies. One of these strategies to achieve organizational excellenceis creating desirable corporate culture. This research has been conducted to identify the path to reachorganizational excellence by creating corporate culture according to the standards and criteria oforganizational excellence. The result of the so-called research is this paper in which researchers foundtwenty models and components of corporate culture and based on the Industry, organizational goals andEFQM model developed a model called "The Eskimo model of Culture-Excellence". The method of theresearch is survey and field study and the questionnaires were distributed among 116 managers andemployees. To assess the reliability of questionnaires, Cronbach alpha was measured to be 95% in the idealsituation and 0/97 in the current situation. Systematic sampling was done and in the pre-test stage 45questionnaires were distributed. A comparison between the current and the ideal corporate culture based onthe views of managers and employees was done and finally it has been concluded that corporate culture isthe main factor to facilitate corporate excellence and success in order to achieve organizational effectiveness.The contribution of this paper is that it proposes a localized –applicable model of corporate excellencethrough reinforcing corporate culture.

  4. Does ACCEL Excel as a Model of Giftedness? A Reply to Commentators

    Science.gov (United States)

    Sternberg, Robert J.

    2017-01-01

    In this essay, I respond to commentators on my article on the Active Concerned Citizenship and Ethical Leadership (ACCEL) model for understanding giftedness. I cover a number of topics that arose in or out of the commentaries, in particular, systems inertia; toxic leadership; teaching for creativity; flight from reality; the role of science,…

  5. Sustainable Enterprise Excellence

    DEFF Research Database (Denmark)

    Edgeman, Rick

    2013-01-01

    Structured Abstract Purpose: Sustainable Enterprise Excellence (SEE) is defined and developed through integration and expansion of business excellence modeling and sustainability thought. The intent is to enable simple yet reliable enterprise assessment of triple bottom line (TBL) performance...... and produce actionable enterprise foresight that can enable next best practices and sources of sustainable competitive advantage through innovation. Methodology: Key elements of SEE are identified from various business excellence and sustainability reporting sources, including the Global Reporting Initiative......, the UN Global Compact 10 Principles, and criteria of the European Quality Award and America’s Baldrige National Quality Award. From these a model and key criteria are distilled, maturity scales developed, and a simple means of assessment presented. Findings: A compact model and supporting maturity...

  6. Regression analysis understanding and building business and economic models using Excel

    CERN Document Server

    Wilson, J Holton

    2012-01-01

    The technique of regression analysis is used so often in business and economics today that an understanding of its use is necessary for almost everyone engaged in the field. This book will teach you the essential elements of building and understanding regression models in a business/economic context in an intuitive manner. The authors take a non-theoretical treatment that is accessible even if you have a limited statistical background. It is specifically designed to teach the correct use of regression, while advising you of its limitations and teaching about common pitfalls. This book describe

  7. Advanced methods for modeling water-levels and estimating drawdowns with SeriesSEE, an Excel add-in

    Science.gov (United States)

    Halford, Keith; Garcia, C. Amanda; Fenelon, Joe; Mirus, Benjamin B.

    2012-12-21

    Water-level modeling is used for multiple-well aquifer tests to reliably differentiate pumping responses from natural water-level changes in wells, or “environmental fluctuations.” Synthetic water levels are created during water-level modeling and represent the summation of multiple component fluctuations, including those caused by environmental forcing and pumping. Pumping signals are modeled by transforming step-wise pumping records into water-level changes by using superimposed Theis functions. Water-levels can be modeled robustly with this Theis-transform approach because environmental fluctuations and pumping signals are simulated simultaneously. Water-level modeling with Theis transforms has been implemented in the program SeriesSEE, which is a Microsoft® Excel add-in. Moving average, Theis, pneumatic-lag, and gamma functions transform time series of measured values into water-level model components in SeriesSEE. Earth tides and step transforms are additional computed water-level model components. Water-level models are calibrated by minimizing a sum-of-squares objective function where singular value decomposition and Tikhonov regularization stabilize results. Drawdown estimates from a water-level model are the summation of all Theis transforms minus residual differences between synthetic and measured water levels. The accuracy of drawdown estimates is limited primarily by noise in the data sets, not the Theis-transform approach. Drawdowns much smaller than environmental fluctuations have been detected across major fault structures, at distances of more than 1 mile from the pumping well, and with limited pre-pumping and recovery data at sites across the United States. In addition to water-level modeling, utilities exist in SeriesSEE for viewing, cleaning, manipulating, and analyzing time-series data.

  8. The EFQM excellence model: European and Dutch experiences with the EFQM approach in health care. European Foundation for Quality Management.

    Science.gov (United States)

    Nabitz, U; Klazinga, N; Walburg, J

    2000-06-01

    One way to meet the challenges in creating a high performance organization in health care is the approach of the European Foundation for Quality Management (EFQM). The Foundation is in the tradition of the American Malcolm Baldrige Award and was initiated by the European Commission and 14 European multi-national organizations in 1988. The essence of the approach is the EFQM Model, which can be used as a self-assessment instrument on all levels of a health care organization and as an auditing instrument for the Quality Award. In 1999 the EFQM Model was revised but its principles remained the same. In The Netherlands many health care organizations apply the EFQM Model. In addition to improvement projects, peer review of professional practices, accreditation and certification, the EFQM Approach is used mainly as a framework for quality management and as a conceptualization for organizational excellence. The Dutch National Institute for Quality, the Instituut Nederlandse Kwaliteit, delivers training and supports self-assessment and runs the Dutch quality award programme. Two specific guidelines for health care organizations, 'Positioning and Improving' and 'Self-Assessment', have been developed and are used frequently. To illustrate the EFQM approach in The Netherlands, the improvement project of the Jellinek Centre is described. The Jellinek Centre conducted internal and external assessments and received in 1996, as the first health care organization, the Dutch Quality Prize.

  9. VOLATILECALC: A silicate melt-H2O-CO2 solution model written in Visual Basic for excel

    Science.gov (United States)

    Newman, S.; Lowenstern, J. B.

    2002-01-01

    We present solution models for the rhyolite-H2O-CO2 and basalt-H2O-CO2 systems at magmatic temperatures and pressures below ~ 5000 bar. The models are coded as macros written in Visual Basic for Applications, for use within MicrosoftR Excel (Office'98 and 2000). The series of macros, entitled VOLATILECALC, can calculate the following: (1) Saturation pressures for silicate melt of known dissolved H2O and CO2 concentrations and the corresponding equilibrium vapor composition; (2) open- and closed-system degassing paths (melt and vapor composition) for depressurizing rhyolitic and basaltic melts; (3) isobaric solubility curves for rhyolitic and basaltic melts; (4) isoplethic solubility curves (constant vapor composition) for rhyolitic and basaltic melts; (5) polybaric solubility curves for the two end members and (6) end member fugacities of H2O and CO2 vapors at magmatic temperatures. The basalt-H2O-CO2 macros in VOLATILECALC are capable of calculating melt-vapor solubility over a range of silicate-melt compositions by using the relationships provided by Dixon (American Mineralogist 82 (1997) 368). The output agrees well with the published solution models and experimental data for silicate melt-vapor systems for pressures below 5000 bar. ?? 2002 Elsevier Science Ltd. All rights reserved.

  10. Sector-Wide Transformational Leadership--How Effectively Is the EFQM Excellence Model[R] Used in the UK FE Sector?

    Science.gov (United States)

    Cartmell, Jonathan; Binsardi, Ben; McLean, Alexis

    2011-01-01

    This seminal study investigates the use of the EFQM Excellence Model[R] in the UK Further Education sector. Following initial interviews with Senior Managers and Quality Consultants, an online survey was sent to Principals and Senior Managers in all Colleges across the UK to critically investigate the relationship between the use of the Model and…

  11. A model comparison approach shows stronger support for economic models of fertility decline.

    Science.gov (United States)

    Shenk, Mary K; Towner, Mary C; Kress, Howard C; Alam, Nurul

    2013-05-14

    The demographic transition is an ongoing global phenomenon in which high fertility and mortality rates are replaced by low fertility and mortality. Despite intense interest in the causes of the transition, especially with respect to decreasing fertility rates, the underlying mechanisms motivating it are still subject to much debate. The literature is crowded with competing theories, including causal models that emphasize (i) mortality and extrinsic risk, (ii) the economic costs and benefits of investing in self and children, and (iii) the cultural transmission of low-fertility social norms. Distinguishing between models, however, requires more comprehensive, better-controlled studies than have been published to date. We use detailed demographic data from recent fieldwork to determine which models produce the most robust explanation of the rapid, recent demographic transition in rural Bangladesh. To rigorously compare models, we use an evidence-based statistical approach using model selection techniques derived from likelihood theory. This approach allows us to quantify the relative evidence the data give to alternative models, even when model predictions are not mutually exclusive. Results indicate that fertility, measured as either total fertility or surviving children, is best explained by models emphasizing economic factors and related motivations for parental investment. Our results also suggest important synergies between models, implicating multiple causal pathways in the rapidity and degree of recent demographic transitions.

  12. Excel Data Analysis your visual blueprint for creating and analyzing data, charts and PivotTables

    CERN Document Server

    Etheridge, Denise

    2010-01-01

    Advanced techniques for Excel power users. Crunch and analyze Excel data the way the professionals do with this clean, uncluttered, visual guide to advanced Excel techniques. Using numerous screenshots and easy-to-follow numbered steps, this book clearly shows you how to perform professional-level modeling, charting, data access, data slicing, and other functions. You'll find super techniques for getting the most out of Excel's statistical and financial functions, Excel PivotTables and PivotCharts, Excel Solver and BackSolver, and more.: Provides a clear look at power-using Excel, the world's

  13. TK Modeler version 1.0, a Microsoft® Excel®-based modeling software for the prediction of diurnal blood/plasma concentration for toxicokinetic use.

    Science.gov (United States)

    McCoy, Alene T; Bartels, Michael J; Rick, David L; Saghir, Shakil A

    2012-07-01

    TK Modeler 1.0 is a Microsoft® Excel®-based pharmacokinetic (PK) modeling program created to aid in the design of toxicokinetic (TK) studies. TK Modeler 1.0 predicts the diurnal blood/plasma concentrations of a test material after single, multiple bolus or dietary dosing using known PK information. Fluctuations in blood/plasma concentrations based on test material kinetics are calculated using one- or two-compartment PK model equations and the principle of superposition. This information can be utilized for the determination of appropriate dosing regimens based on reaching a specific desired C(max), maintaining steady-state blood/plasma concentrations, or other exposure target. This program can also aid in the selection of sampling times for accurate calculation of AUC(24h) (diurnal area under the blood concentration time curve) using sparse-sampling methodologies (one, two or three samples). This paper describes the construction, use and validation of TK Modeler. TK Modeler accurately predicted blood/plasma concentrations of test materials and provided optimal sampling times for the calculation of AUC(24h) with improved accuracy using sparse-sampling methods. TK Modeler is therefore a validated, unique and simple modeling program that can aid in the design of toxicokinetic studies.

  14. Excel 2007 Charts

    CERN Document Server

    Walkenbach, John

    2008-01-01

    Excel, the top number-crunching tool, now offers a vastly improved charting function to help you give those numbers dimension and relativity. John Walkenbach, a.k.a. Mr. Spreadsheet, clearly explains all these charting features and shows you how to choose the right chart for your needs. You'll learn to modify data within the chart, deal with missing data, format your chart, use trend lines, construct "impossible" charts, create charts from pivot tables, dress them up with graphics, and more. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.

  15. The Exploration and Practice of Gradually Industrialization Model in Software Engineering Education: A Factual Instance of the Excellent Engineer Plan of China

    Science.gov (United States)

    Liu, Shu; Ma, Peijun; Li, Dong

    2012-01-01

    The current education model and practices in the Higher education sector in China have been successful in educating students for academic excellence, for producing industry-linked and practice-oriented graduates, who could quickly fit into the industrial working environment, has been a problem. There is a big gap between the theoretical knowledge…

  16. The Exploration and Practice of Gradually Industrialization Model in Software Engineering Education: A Factual Instance of the Excellent Engineer Plan of China

    Science.gov (United States)

    Liu, Shu; Ma, Peijun; Li, Dong

    2012-01-01

    The current education model and practices in the Higher education sector in China have been successful in educating students for academic excellence, for producing industry-linked and practice-oriented graduates, who could quickly fit into the industrial working environment, has been a problem. There is a big gap between the theoretical knowledge…

  17. Evaluating University-Industry Collaboration: The European Foundation of Quality Management Excellence Model-Based Evaluation of University-Industry Collaboration

    Science.gov (United States)

    Kauppila, Osmo; Mursula, Anu; Harkonen, Janne; Kujala, Jaakko

    2015-01-01

    The growth in university-industry collaboration has resulted in an increasing demand for methods to evaluate it. This paper presents one way to evaluate an organization's collaborative activities based on the European Foundation of Quality Management excellence model. Success factors of collaboration are derived from literature and compared…

  18. TerCharts: a VBA-MS Excel multiternary and multipurpose charting utility for data analysis, presentation, and modeling in environmental and earth sciences

    Science.gov (United States)

    Esawi, E. K.

    2009-03-01

    TerCharts is a comprehensive, fast, flexible, and versatile ternary charting utility that can be used for ternary data presentation analysis and modeling across many scientific disciplines. TerCharts is developed using Microsoft (MS) Excel 2003 and Visual Basic for Applications (VBA) which is an object oriented programming language developed by MS as a tool to enhance the capabilities of MS products. The Excel-VBA interface is important because normally chemical, geochemical, and mineralogical data used in teaching and basic research are processed using Excel spreadsheets, making TerCharts a more convenient tool for generating ternary charts which in turn can be used for data presentation and analysis. Ternary charts generated by this utility can be improved, edited, and modified utilizing MS Excel’s powerful charting and editing techniques.

  19. Using user models in Matlab® within the Aspen Plus® interface with an Excel® link

    Directory of Open Access Journals (Sweden)

    Javier Fontalvo Alzate

    2014-07-01

    Full Text Available Process intensification and new technologies require tools for process design that can be integrated into well-known simulation software, such as Aspen Plus®. Thus, unit operations that are not included in traditional Aspen Plus software packages can be simulated with Matlab® and integrated within the Aspen Plus interface. In this way, the user can take advantage of all of the tools of Aspen Plus, such as optimization, sensitivity analysis and cost estimation. This paper gives a detailed description of how to implement this integration. The interface between Matlab and Aspen Plus is accomplished by sending the relevant information from Aspen Plus to Excel, which feeds the information to a Matlab routine. Once the Matlab routine processes the information, it is returned to Excel and to Aspen Plus. This paper includes the Excel and Matlab template files so the reader can implement their own simulations. By applying the protocol described here, a hybrid distillation-vapor permeation system has been simulated as an example of the applications that can be implemented. For the hybrid system, the effect of membrane selectivity on membrane area and reboiler duty for the partial dehydration of ethanol is studied. Very high selectivities are not necessarily required for an optimum hybrid distillation and vapor permeation system.

  20. BUSINESS EXCELLENCE AS A CRUCIAL COMPONENT FOR ORGANIZATION COMPETITIVENESS

    Directory of Open Access Journals (Sweden)

    Zeljko Pozega

    2014-12-01

    Full Text Available Background: Business excellence represents one of the most valuable management means of achieving competitive advantage of organizations. Modern and global market demands new organizational approaches for the long-term improvement at all organization levels. Objectives: This paper is concerned with the level of business excellence in Sibenik-Knin County and the level of knowledge about the EFQM model. Moreover, this paper is concerned with the level of knowledge of the top management concerning the business excellence and quality principles. Methods/Approach: For the purpose of this paper, the research was conducted among organizations in Sibenik-Knin County. Results: The results showed that the organizations in Sibenik-Knin County lack the initiatives for the systematic approach and implementation of business excellence model, but poses the knowledge about the basic concepts of business excellence. Conclusions: The research had showed that the organizations believe that the ISO certification is sufficient for strengthening competitive advantage and organization success.

  1. Excel 2013 simplified

    CERN Document Server

    McFedries, Paul

    2013-01-01

    A friendly, visual approach to learning the basics of Excel 2013 As the world's leading spreadsheet program, Excel is a spreadsheet and data analysis tool that is part of the Microsoft Office suite. The new Excel 2013 includes new features and functionalities that require users of older versions to re-learn the application. However, whether you're switching from an earlier version or learning Excel for the first time, this easy-to-follow visual guide gets you going with Excel 2013 quickly and easily. Numbered steps as well as full-color screen shots, concise information, and helpfu

  2. Excel Dashboards & Reports

    CERN Document Server

    Alexander, Michael

    2010-01-01

    The go to resource for how to use Excel dashboards and reports to better conceptualize data. Many Excel books do an adequate job of discussing the individual functions and tools that can be used to create an "Excel Report." What they don't offer is the most effective ways to present and report data. Offering a comprehensive review of a wide array of technical and analytical concepts, Excel Reports and Dashboards helps Excel users go from reporting data with simple tables full of dull numbers, to presenting key information through the use of high-impact, meaningful reports and dashboards that w

  3. Assessing the "Rothstein Falsification Test": Does It Really Show Teacher Value-Added Models Are Biased?

    Science.gov (United States)

    Goldhaber, Dan; Chaplin, Duncan Dunbar

    2015-01-01

    In an influential paper, Jesse Rothstein (2010) shows that standard value-added models (VAMs) suggest implausible and large future teacher effects on past student achievement. This is the basis of a falsification test that "appears" to indicate bias in typical VAM estimates of teacher contributions to student learning on standardized…

  4. Model Penilaian dan Pemilihan Trade Show Bagi Industri Kreatif di Sektor Mode

    Directory of Open Access Journals (Sweden)

    Afrin Fauzya Rizana

    2017-07-01

    Full Text Available The article identifies the criteria for choosing a trade show and develops a basic model of exhibition selection for creative industry players before deciding to participate in a trade show. It is necessary to ensure that expenses in terms of business, money, and time, will be worth the results. Based on literature review and interviews, six criteria were used, namely location, booth position, organizational reputation, cost estimation, prestige, and reputation of other participants. After selection criteria are identified, then calculations are performed to measure the criteria weight by using the AHP approach. Based on weight calculations, it was found that booth positions had the highest importance weight, followed by trade show location, organizers reputation, cost estimation, prestige and reputation of other participants. The weight value is then used to calculate the trade show's prediction value. The predicted value generated from the model is then compared to the value of the past data. The model has an accuracy rate of 89% and does not have a significant difference between the value generated by the model and the value of the past data.

  5. Quality Management and Business Excellence

    OpenAIRE

    Vasile Dinu

    2017-01-01

    An excellent organization involves much more than the implementation and the certification of one or more models of management systems. It means developing techniques and tools of busin excellence which lead the organization to outstanding performance on quality, costs and deadlines in order to meet the expectations of all their stakeholders. Such an approach is needed especially in the context of an economy marked by globalization, extremely complex and dynamic that causes spectacular change...

  6. 库存-运输系统整合优化Excel模型求解%The Excel Model of Inventory/Transportation Integrated Optimization

    Institute of Scientific and Technical Information of China (English)

    于文玲; 莫云萍

    2011-01-01

    The paper puts forward an inventory/transport integrated optimization model using software Excel Solver, the calculated logistics cost of which is much less than that of the traditional inventory/ transportation model. The software Excel Solver is to shown to be of quite impressive capability in solving inventory and transportation planning problems.%提出了库存-运输整合优化模型,将库存与运输问题看作一个系统整体考虑,比传统的将库存、运输单独考虑的物流成本要少的多.通过Excel模型的建立与求解,展现了Excel软件在规划求解方面的不可忽视的作用.

  7. Pomalidomide shows significant therapeutic activity against CNS lymphoma with a major impact on the tumor microenvironment in murine models.

    Science.gov (United States)

    Li, Zhimin; Qiu, Yushi; Personett, David; Huang, Peng; Edenfield, Brandy; Katz, Jason; Babusis, Darius; Tang, Yang; Shirely, Michael A; Moghaddam, Mehran F; Copland, John A; Tun, Han W

    2013-01-01

    Primary CNS lymphoma carries a poor prognosis. Novel therapeutic agents are urgently needed. Pomalidomide (POM) is a novel immunomodulatory drug with anti-lymphoma activity. CNS pharmacokinetic analysis was performed in rats to assess the CNS penetration of POM. Preclinical evaluation of POM was performed in two murine models to assess its therapeutic activity against CNS lymphoma. The impact of POM on the CNS lymphoma immune microenvironment was evaluated by immunohistochemistry and immunofluorescence. In vitro cell culture experiments were carried out to further investigate the impact of POM on the biology of macrophages. POM crosses the blood brain barrier with CNS penetration of ~ 39%. Preclinical evaluations showed that it had significant therapeutic activity against CNS lymphoma with significant reduction in tumor growth rate and prolongation of survival, that it had a major impact on the tumor microenvironment with an increase in macrophages and natural killer cells, and that it decreased M2-polarized tumor-associated macrophages and increased M1-polarized macrophages when macrophages were evaluated based on polarization status. In vitro studies using various macrophage models showed that POM converted the polarization status of IL4-stimulated macrophages from M2 to M1, that M2 to M1 conversion by POM in the polarization status of lymphoma-associated macrophages is dependent on the presence of NK cells, that POM induced M2 to M1 conversion in the polarization of macrophages by inactivating STAT6 signaling and activating STAT1 signaling, and that POM functionally increased the phagocytic activity of macrophages. Based on our findings, POM is a promising therapeutic agent for CNS lymphoma with excellent CNS penetration, significant preclinical therapeutic activity, and a major impact on the tumor microenvironment. It can induce significant biological changes in tumor-associated macrophages, which likely play a major role in its therapeutic activity against CNS

  8. Sustainable Enterprise Excellence

    DEFF Research Database (Denmark)

    Edgeman, Rick; Williams, Joseph; Eskildsen, Jacob Kjær

    , supply chain, customer-related, human capital, financial, marketplace, societal, and environmental performance. Sustainable Enterprise Excellence integrates ethical, efficient and effective (E3) enterprise governance with 3E (equity, ecology, economy) Triple Top Line strategy throughout enterprise...... culture and activities to produce Triple Bottom Line 3P (people, planet, profit) performance that are simultaneously pragmatic, innovative and supportive of R3 (Edgeman, 2013). Sustainable Enterprise Excellence (Edgeman & Eskildsen, 2013) or SEE is analogous to Business & Performance Excellence. The role...

  9. C3-Luc Cells Are an Excellent Model for Evaluation of Cellular Immunity following HPV16L1 Vaccination.

    Directory of Open Access Journals (Sweden)

    Li-Li Li

    Full Text Available C3 and TC-1 are the two model cell lines most commonly used in studies of vaccines and drugs against human papillomavirus (HPV infection. Because C3 cells contain both the HPV16 E and L genes, but TC-1 cells contain only the HPV16 E genes, C3 cells are usually used as the model cell line in studies targeting the HPV16 L protein. However, expression of the L1 protein is difficult to detect in C3 cells using common methods. In our study, Short tandem repeat analysis (STR was used to demonstrate that C3 cells are indeed derived from mice, PCR results show that HPV16 L1, E6 and E7 genes were detected in C3 genomic DNA, and RT-PCR results demonstrated that L1 transcription had occurred in C3 cells. However, the expression of C3 protein was not found in the results of western blot and immunohistochemistry (IHC. Growth and proliferation of C3 were inhibited by mice spleen lymphocytes that had been immunized with a vaccine against HPV16L1. The luciferase gene was integrated into C3 cells, and it was confirmed that addition of the exogenous gene had no effect on C3 cells by comparing cell growth and tumor formation with untransformed cells. Cells stably expressing luciferase (C3-luc were screened and subcutaneously injected into the mice. Tumors became established and were observed using a Spectrum Pre-clinical in Vivo Imaging System. Tumor size of mice in the different groups at various time points was calculated by counting photons. The sensitivity of the animals to the vaccine was quantified by statistical comparison. Ten or 30 days following injection of the C3-luc cells, tumor size differed significantly between the PBS and vaccine groups, indicating that C3 cells were susceptible to vaccination even after tumors were formed in vivo.

  10. Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show repetitive grooming after induced fear.

    Science.gov (United States)

    Xu, Meiyu; Li, Lina; Ohtsu, Hiroshi; Pittenger, Christopher

    2015-05-19

    Tics, such as are seen in Tourette syndrome (TS), are common and can cause profound morbidity, but they are poorly understood. Tics are potentiated by psychostimulants, stress, and sleep deprivation. Mutations in the gene histidine decarboxylase (Hdc) have been implicated as a rare genetic cause of TS, and Hdc knockout mice have been validated as a genetic model that recapitulates phenomenological and pathophysiological aspects of the disorder. Tic-like stereotypies in this model have not been observed at baseline but emerge after acute challenge with the psychostimulant d-amphetamine. We tested the ability of an acute stressor to stimulate stereotypies in this model, using tone fear conditioning. Hdc knockout mice acquired conditioned fear normally, as manifested by freezing during the presentation of a tone 48h after it had been paired with a shock. During the 30min following tone presentation, knockout mice showed increased grooming. Heterozygotes exhibited normal freezing and intermediate grooming. These data validate a new paradigm for the examination of tic-like stereotypies in animals without pharmacological challenge and enhance the face validity of the Hdc knockout mouse as a pathophysiologically grounded model of tic disorders.

  11. Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy.

    Science.gov (United States)

    de Munck, Estefanía; Palomo, Valle; Muñoz-Sáez, Emma; Perez, Daniel I; Gómez-Miguel, Begoña; Solas, M Teresa; Gil, Carmen; Martínez, Ana; Arahuetes, Rosa M

    2016-01-01

    Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that has no effective treatment up to date. Drug discovery tasks have been hampered due to the lack of knowledge in its molecular etiology together with the limited animal models for research. Recently, a motor neuron disease animal model has been developed using β-N-methylamino-L-alanine (L-BMAA), a neurotoxic amino acid related to the appearing of ALS. In the present work, the neuroprotective role of VP2.51, a small heterocyclic GSK-3 inhibitor, is analysed in this novel murine model together with the analysis of autophagy. VP2.51 daily administration for two weeks, starting the first day after L-BMAA treatment, leads to total recovery of neurological symptoms and prevents the activation of autophagic processes in rats. These results show that the L-BMAA murine model can be used to test the efficacy of new drugs. In addition, the results confirm the therapeutic potential of GSK-3 inhibitors, and specially VP2.51, for the disease-modifying future treatment of motor neuron disorders like ALS.

  12. Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy

    Science.gov (United States)

    de Munck, Estefanía; Palomo, Valle; Muñoz-Sáez, Emma; Perez, Daniel I.; Gómez-Miguel, Begoña; Solas, M. Teresa; Gil, Carmen; Martínez, Ana; Arahuetes, Rosa M.

    2016-01-01

    Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that has no effective treatment up to date. Drug discovery tasks have been hampered due to the lack of knowledge in its molecular etiology together with the limited animal models for research. Recently, a motor neuron disease animal model has been developed using β-N-methylamino-L-alanine (L-BMAA), a neurotoxic amino acid related to the appearing of ALS. In the present work, the neuroprotective role of VP2.51, a small heterocyclic GSK-3 inhibitor, is analysed in this novel murine model together with the analysis of autophagy. VP2.51 daily administration for two weeks, starting the first day after L-BMAA treatment, leads to total recovery of neurological symptoms and prevents the activation of autophagic processes in rats. These results show that the L-BMAA murine model can be used to test the efficacy of new drugs. In addition, the results confirm the therapeutic potential of GSK-3 inhibitors, and specially VP2.51, for the disease-modifying future treatment of motor neuron disorders like ALS. PMID:27631495

  13. Ascidians as excellent chordate models for studying the development of the nervous system during embryogenesis and metamorphosis.

    Science.gov (United States)

    Sasakura, Yasunori; Mita, Kaoru; Ogura, Yosuke; Horie, Takeo

    2012-04-01

    The swimming larvae of the chordate ascidians possess a dorsal hollowed central nervous system (CNS), which is homologous to that of vertebrates. Despite the homology, the ascidian CNS consists of a countable number of cells. The simple nervous system of ascidians provides an excellent experimental system to study the developmental mechanisms of the chordate nervous system. The neural fate of the cells consisting of the ascidian CNS is determined in both autonomous and non-autonomous fashion during the cleavage stage. The ascidian neural plate performs the morphogenetic movement of neural tube closure that resembles that in vertebrate neural tube formation. Following neurulation, the CNS is separated into five distinct regions, whose homology with the regions of vertebrate CNS has been discussed. Following their larval stage, ascidians undergo a metamorphosis and become sessile adults. The metamorphosis is completed quickly, and therefore the metamorphosis of ascidians is a good experimental system to observe the reorganization of the CNS during metamorphosis. A recent study has shown that the major parts of the larval CNS remain after the metamorphosis to form the adult CNS. In contrast to such a conserved manner of CNS reorganization, most larval neurons disappear during metamorphosis. The larval glial cells in the CNS are the major source for the formation of the adult CNS, and some of the glial cells produce adult neurons.

  14. MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy.

    Directory of Open Access Journals (Sweden)

    Lore Becker

    Full Text Available Recently, mutations in the mitochondrial translation optimization factor 1 gene (MTO1 were identified as causative in children with hypertrophic cardiomyopathy, lactic acidosis and respiratory chain defect. Here, we describe an MTO1-deficient mouse model generated by gene trap mutagenesis that mirrors the human phenotype remarkably well. As in patients, the most prominent signs and symptoms were cardiovascular and included bradycardia and cardiomyopathy. In addition, the mutant mice showed a marked worsening of arrhythmias during induction and reversal of anaesthesia. The detailed morphological and biochemical workup of murine hearts indicated that the myocardial damage was due to complex I deficiency and mitochondrial dysfunction. In contrast, neurological examination was largely normal in Mto1-deficient mice. A translational consequence of this mouse model may be to caution against anaesthesia-related cardiac arrhythmias which may be fatal in patients.

  15. Transchromosomic cell model of Down syndrome shows aberrant migration, adhesion and proteome response to extracellular matrix

    Directory of Open Access Journals (Sweden)

    Cotter Finbarr E

    2009-08-01

    Full Text Available Abstract Background Down syndrome (DS, caused by trisomy of human chromosome 21 (HSA21, is the most common genetic birth defect. Congenital heart defects (CHD are seen in 40% of DS children, and >50% of all atrioventricular canal defects in infancy are caused by trisomy 21, but the causative genes remain unknown. Results Here we show that aberrant adhesion and proliferation of DS cells can be reproduced using a transchromosomic model of DS (mouse fibroblasts bearing supernumerary HSA21. We also demonstrate a deacrease of cell migration in transchromosomic cells independently of their adhesion properties. We show that cell-autonomous proteome response to the presence of Collagen VI in extracellular matrix is strongly affected by trisomy 21. Conclusion This set of experiments establishes a new model system for genetic dissection of the specific HSA21 gene-overdose contributions to aberrant cell migration, adhesion, proliferation and specific proteome response to collagen VI, cellular phenotypes linked to the pathogenesis of CHD.

  16. Estimating carbon and showing impacts of drought using satellite data in regression-tree models

    Science.gov (United States)

    Boyte, Stephen; Wylie, Bruce K.; Howard, Danny; Dahal, Devendra; Gilmanov, Tagir G.

    2018-01-01

    Integrating spatially explicit biogeophysical and remotely sensed data into regression-tree models enables the spatial extrapolation of training data over large geographic spaces, allowing a better understanding of broad-scale ecosystem processes. The current study presents annual gross primary production (GPP) and annual ecosystem respiration (RE) for 2000–2013 in several short-statured vegetation types using carbon flux data from towers that are located strategically across the conterminous United States (CONUS). We calculate carbon fluxes (annual net ecosystem production [NEP]) for each year in our study period, which includes 2012 when drought and higher-than-normal temperatures influence vegetation productivity in large parts of the study area. We present and analyse carbon flux dynamics in the CONUS to better understand how drought affects GPP, RE, and NEP. Model accuracy metrics show strong correlation coefficients (r) (r ≥ 94%) between training and estimated data for both GPP and RE. Overall, average annual GPP, RE, and NEP are relatively constant throughout the study period except during 2012 when almost 60% less carbon is sequestered than normal. These results allow us to conclude that this modelling method effectively estimates carbon dynamics through time and allows the exploration of impacts of meteorological anomalies and vegetation types on carbon dynamics.

  17. Beginning Microsoft Excel 2010

    CERN Document Server

    Katz, Abbott

    2010-01-01

    Beginning Microsoft Excel 2010 is a practical, step-by-step guide to getting started with the world's most widely used spreadsheet application. The book offers a hands-on approach to learning how to create and edit spreadsheets, use various calculation formulas, employ charts/graphs, and get work done efficiently. Microsoft is rolling out several new features with Excel 2010 - perhaps the most notable is the ability to use Excel 2010 online and this collaborate on a project in real time. Beginning Microsoft Office 2010 keeps you up-to-date with all of these new features and more. What you'll l

  18. Excel for Cost Engineers

    Science.gov (United States)

    Butts, Glenn C.

    2007-01-01

    Excel is a powerful tool with a plethora of largely unused capabilities that can make the life of an engineer cognizant of them a great deal easier. This paper offers tips, tricks and techniques for better worksheets. Including the use of data validation, conditional formatting, subtotals, text formulas, custom functions and much more. It is assumed that the reader will have a cursory understanding of Excel so the basics will not be covered, if you get hung up try Excel's built in help menus, or a good book.

  19. Excel dashboards and reports

    CERN Document Server

    Alexander, Michael

    2013-01-01

    Learn to use Excel dashboards and reports to better conceptualize data Updated for all the?latest features and capabilities of Excel 2013, this go-to resource provides you with in-depth coverage of the individual functions and tools that can be used to create?compelling Excel reports. Veteran author Michael Alexander walks you through the most effective ways to present and report data. Featuring a comprehensive review of a wide array of technical and analytical concepts, this essential guide helps you go from reporting data with simple tables full of dull numbers to presenting

  20. Excel 2003 for dummies

    CERN Document Server

    Harvey, Greg

    2013-01-01

    Every time you turn around, you run into Excel. It's on yourPC at work. It's on your PC at home. You get Excel files fromyour boss. Wouldn't you like to understand this powerfulMicrosoft Office spreadsheet program, once and for all? Now, youcan crunch financial data, add sparkle to presentations, convertstatic lists of numbers into impressive charts, and discover whatall the shouting's about regarding databases, formulas, andcells. You may even decide that getting organized with a goodspreadsheet is downright useful and fun! Flip open Excel 2003 For Dummies, and you'llquickly start getting th

  1. Excel2003 Formulas

    CERN Document Server

    Walkenbach, John

    2011-01-01

    Everything you need to know about* Mastering operators, error values, naming techniques, and absolute versus relative references* Debugging formulas and using the auditing tools* Importing and exporting XML files and mapping the data to specific cells* Using Excel 2003's rights management feature* Working magic with array formulas* Developing custom formulas to produce the results you needHere's the formula for Excel excellenceFormulas are the lifeblood of spreadsheets, and no one can bring a spreadsheet to life like John Walkenbach. In this detailed reference guide, he delves deeply into unde

  2. DEVELOPMENT OF RIVER FLOOD ROUTING MODEL USING NON-LINEAR MUSKINGUM EQUATION AND EXCEL TOOL 'GANetXL'

    OpenAIRE

    Briti Sundar Sil; Angana Borah; Subhrajyoti Deb; Biplab Das

    2016-01-01

    Flood routing is of utmost importance to water resources engineers and hydrologist. Muskingum model is one of the popular methods for river flood routing which often require a huge computational work. To solve the routing parameters, most of the established methods require knowledge about different computer programmes and sophisticated models. So, it is beneficial to have a tool which is comfortable to users having more knowledge about everyday decision making problems rather than the develop...

  3. Rubber particle proteins, HbREF and HbSRPP, show different interactions with model membranes.

    Science.gov (United States)

    Berthelot, Karine; Lecomte, Sophie; Estevez, Yannick; Zhendre, Vanessa; Henry, Sarah; Thévenot, Julie; Dufourc, Erick J; Alves, Isabel D; Peruch, Frédéric

    2014-01-01

    The biomembrane surrounding rubber particles from the hevea latex is well known for its content of numerous allergen proteins. HbREF (Hevb1) and HbSRPP (Hevb3) are major components, linked on rubber particles, and they have been shown to be involved in rubber synthesis or quality (mass regulation), but their exact function is still to be determined. In this study we highlighted the different modes of interactions of both recombinant proteins with various membrane models (lipid monolayers, liposomes or supported bilayers, and multilamellar vesicles) to mimic the latex particle membrane. We combined various biophysical methods (polarization-modulation-infrared reflection-adsorption spectroscopy (PM-IRRAS)/ellipsometry, attenuated-total reflectance Fourier-transform infrared (ATR-FTIR), solid-state nuclear magnetic resonance (NMR), plasmon waveguide resonance (PWR), fluorescence spectroscopy) to elucidate their interactions. Small rubber particle protein (SRPP) shows less affinity than rubber elongation factor (REF) for the membranes but displays a kind of "covering" effect on the lipid headgroups without disturbing the membrane integrity. Its structure is conserved in the presence of lipids. Contrarily, REF demonstrates higher membrane affinity with changes in its aggregation properties, the amyloid nature of REF, which we previously reported, is not favored in the presence of lipids. REF binds and inserts into membranes. The membrane integrity is highly perturbed, and we suspect that REF is even able to remove lipids from the membrane leading to the formation of mixed micelles. These two homologous proteins show affinity to all membrane models tested but neatly differ in their interacting features. This could imply differential roles on the surface of rubber particles.

  4. Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme.

    Science.gov (United States)

    Bai, Ren-Yuan; Staedtke, Verena; Aprhys, Colette M; Gallia, Gary L; Riggins, Gregory J

    2011-09-01

    Glioblastoma multiforme (GBM) is the most common and aggressive brain cancer, and despite treatment advances, patient prognosis remains poor. During routine animal studies, we serendipitously observed that fenbendazole, a benzimidazole antihelminthic used to treat pinworm infection, inhibited brain tumor engraftment. Subsequent in vitro and in vivo experiments with benzimidazoles identified mebendazole as the more promising drug for GBM therapy. In GBM cell lines, mebendazole displayed cytotoxicity, with half-maximal inhibitory concentrations ranging from 0.1 to 0.3 µM. Mebendazole disrupted microtubule formation in GBM cells, and in vitro activity was correlated with reduced tubulin polymerization. Subsequently, we showed that mebendazole significantly extended mean survival up to 63% in syngeneic and xenograft orthotopic mouse glioma models. Mebendazole has been approved by the US Food and Drug Administration for parasitic infections, has a long track-record of safe human use, and was effective in our animal models with doses documented as safe in humans. Our findings indicate that mebendazole is a possible novel anti-brain tumor therapeutic that could be further tested in clinical trials.

  5. Striving for Excellence

    DEFF Research Database (Denmark)

    Hattke, Fabian; Blaschke, Steffen

    2015-01-01

    in administrative or leading positions and policy makers concerned with higher education. The more diverse a top management team is in terms of multiple disciplinary backgrounds, the more likely they succeed in driving the university towards academic excellence. Originality/value: - The study is among the first......Purpose: - The purpose of this paper is to evaluate the influence of top management team diversity on academic excellence in universities. Academic excellence is conceptualized as successfully gaining funds for inter-organizational research collaborations, interdisciplinary graduate schools......, and high ranked scientific reputation. Design/methodology/approach: -The study applies upper echelon theory to universities. Three hypotheses are developed: 1) (Overall) top management team heterogeneity is positively associated with successful funding of excellence clusters, 2) (Overall) top management...

  6. Sustainable Enterprise Excellence

    DEFF Research Database (Denmark)

    Edgeman, Rick; Williams, Joseph; Eskildsen, Jacob Kjær

    Sustainable Enterprise Excellence balances complementary and competing interests of key stakeholder segments, including society and the natural environment and increases the likelihood of superior and sustainable competitive positioning and hence long-term enterprise success that is defined......, supply chain, customer-related, human capital, financial, marketplace, societal, and environmental performance. Sustainable Enterprise Excellence integrates ethical, efficient and effective (E3) enterprise governance with 3E (equity, ecology, economy) Triple Top Line strategy throughout enterprise...... culture and activities to produce Triple Bottom Line 3P (people, planet, profit) performance that are simultaneously pragmatic, innovative and supportive of R3 (Edgeman, 2013). Sustainable Enterprise Excellence (Edgeman & Eskildsen, 2013) or SEE is analogous to Business & Performance Excellence. The role...

  7. Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationships.

    Science.gov (United States)

    Keeney, Paula M; Dunham, Lisa D; Quigley, Caitlin K; Morton, Stephanie L; Bergquist, Kristen E; Bennett, James P

    2009-12-01

    Sporadic Parkinson's disease (sPD) is a nervous system-wide disease that presents with a bradykinetic movement disorder and frequently progresses to include depression and cognitive impairment. Cybrid models of sPD are based on expression of sPD platelet mitochondrial DNA (mtDNA) in neural cells and demonstrate some similarities to sPD brains. In sPD and CTL cybrids we characterized aspects of mitochondrial biogenesis, mtDNA genomics, composition of the respirasome and the relationships among isolated mitochondrial and intact cell respiration. Cybrid mtDNA levels varied and correlated with expression of PGC-1 alpha, a transcriptional co-activator regulator of mitochondrial biogenesis. Levels of mtDNA heteroplasmic mutations were asymmetrically distributed across the mitochondrial genome; numbers of heteroplasmies were more evenly distributed. Neither levels nor numbers of heteroplasmies distinguished sPD from CTL. sPD cybrid mitochondrial ETC subunit protein levels were not altered. Isolated mitochondrial complex I respiration rates showed limited correlation with whole cell complex I respiration rates in both sPD and CTL cybrids. Intact cell respiration during the normoxic-anoxic transition yielded K(m) values for oxygen that directly related to respiration rates in CTL but not in sPD cell lines. Both sPD and CTL cybrid cells are substantially heterogeneous in mitochondrial genomic and physiologic properties. Our results suggest that mtDNA depletion may occur in sPD neurons and could reflect impairment of mitochondrial biogenesis. Cybrids remain a valuable model for some aspects of sPD but their heterogeneity mitigates against a simple designation of sPD phenotype in this cell model.

  8. Striving for Excellence

    DEFF Research Database (Denmark)

    Hattke, Fabian; Blaschke, Steffen

    2015-01-01

    no significant effects. Besides top management team composition, we find that a high number of faculties and a broad inclusion of internal status groups (students, tenured faculty, academic and administrative staff) and external stakeholders in decision making processes may enhance academic excellence......, the study contributes to the body of literature on strategic leadership in pluralistic organizations. It highlights the importance of heterogeneous governance structures and modular organization designs for achieving academic excellence. Practical implications: - The paper may inform practitioners...

  9. Fundamental mathematical model shows that applied electrical field enhances chemotherapy delivery to tumors.

    Science.gov (United States)

    Moarefian, Maryam; Pascal, Jennifer A

    2016-02-01

    Biobarriers imposed by the tumor microenvironment create a challenge to deliver chemotherapeutics effectively. Electric fields can be used to overcome these biobarriers in the form of electrochemotherapy, or by applying an electric field to tissue after chemotherapy has been delivered systemically. A fundamental understanding of the underlying physical phenomena governing tumor response to an applied electrical field is lacking. Building upon the work of Pascal et al. [1], a mathematical model that predicts the fraction of tumor killed due to a direct current (DC) applied electrical field and chemotherapy is developed here for tumor tissue surrounding a single, straight, cylindrical blood vessel. Results show the typical values of various parameters related to properties of the electrical field, tumor tissue and chemotherapy drug that have the most significant influence on the fraction of tumor killed. We show that the applied electrical field enhances tumor death due to chemotherapy and that the direction and magnitude of the applied electrical field have a significant impact on the fraction of tumor killed. Published by Elsevier Inc.

  10. Aerobic Toluene Degraders in the Rhizosphere of a Constructed Wetland Model Show Diurnal Polyhydroxyalkanoate Metabolism.

    Science.gov (United States)

    Lünsmann, Vanessa; Kappelmeyer, Uwe; Taubert, Anja; Nijenhuis, Ivonne; von Bergen, Martin; Heipieper, Hermann J; Müller, Jochen A; Jehmlich, Nico

    2016-07-15

    Constructed wetlands (CWs) are successfully applied for the treatment of waters contaminated with aromatic compounds. In these systems, plants provide oxygen and root exudates to the rhizosphere and thereby stimulate microbial degradation processes. Root exudation of oxygen and organic compounds depends on photosynthetic activity and thus may show day-night fluctuations. While diurnal changes in CW effluent composition have been observed, information on respective fluctuations of bacterial activity are scarce. We investigated microbial processes in a CW model system treating toluene-contaminated water which showed diurnal oscillations of oxygen concentrations using metaproteomics. Quantitative real-time PCR was applied to assess diurnal expression patterns of genes involved in aerobic and anaerobic toluene degradation. We observed stable aerobic toluene turnover by Burkholderiales during the day and night. Polyhydroxyalkanoate synthesis was upregulated in these bacteria during the day, suggesting that they additionally feed on organic root exudates while reutilizing the stored carbon compounds during the night via the glyoxylate cycle. Although mRNA copies encoding the anaerobic enzyme benzylsuccinate synthase (bssA) were relatively abundant and increased slightly at night, the corresponding protein could not be detected in the CW model system. Our study provides insights into diurnal patterns of microbial processes occurring in the rhizosphere of an aquatic ecosystem. Constructed wetlands are a well-established and cost-efficient option for the bioremediation of contaminated waters. While it is commonly accepted knowledge that the function of CWs is determined by the interplay of plants and microorganisms, the detailed molecular processes are considered a black box. Here, we used a well-characterized CW model system treating toluene-contaminated water to investigate the microbial processes influenced by diurnal plant root exudation. Our results indicated stable

  11. Use of a Microsoft Excel based add-in program to calculate plasma sinistrin clearance by a two-compartment model analysis in dogs.

    Science.gov (United States)

    Steinbach, Sarah M L; Sturgess, Christopher P; Dunning, Mark D; Neiger, Reto

    2015-06-01

    Assessment of renal function by means of plasma clearance of a suitable marker has become standard procedure for estimation of glomerular filtration rate (GFR). Sinistrin, a polyfructan solely cleared by the kidney, is often used for this purpose. Pharmacokinetic modeling using adequate software is necessary to calculate disappearance rate and half-life of sinistrin. The purpose of this study was to describe the use of a Microsoft excel based add-in program to calculate plasma sinistrin clearance, as well as additional pharmacokinetic parameters such as transfer rates (k), half-life (t1/2) and volume of distribution (Vss) for sinistrin in dogs with varying degrees of renal function.

  12. A Comparison of Video Modeling, Text-Based Instruction, and No Instruction for Creating Multiple Baseline Graphs in Microsoft Excel

    Science.gov (United States)

    Tyner, Bryan C.; Fienup, Daniel M.

    2015-01-01

    Graphing is socially significant for behavior analysts; however, graphing can be difficult to learn. Video modeling (VM) may be a useful instructional method but lacks evidence for effective teaching of computer skills. A between-groups design compared the effects of VM, text-based instruction, and no instruction on graphing performance.…

  13. Quality Management and Business Excellence

    Directory of Open Access Journals (Sweden)

    Vasile Dinu

    2017-02-01

    Full Text Available An excellent organization involves much more than the implementation and the certification of one or more models of management systems. It means developing techniques and tools of busin excellence which lead the organization to outstanding performance on quality, costs and deadlines in order to meet the expectations of all their stakeholders. Such an approach is needed especially in the context of an economy marked by globalization, extremely complex and dynamic that causes spectacular changes in the business environment by integrating quality management principles on purpose to develop sustainable excellence. Not coincidentally, the new edition of the European excellence model EFQM integrates for the first time the principle "managing with agility“ with the principles: “developing organizational capability”, “harnessing creativity & innovation”, “adding value to the customer”, “sustaining outstanding results” for the organization and “creating a sustainable future”. Also, the new model for quality management system defined by the edition from 2015 of ISO 9000 standards , promotes the process-based approach, incorporating the cycle "Plan - Do − Check − Act" (PDCA and the risk-based thinking, focusing on organizational change and innovation, in order to ensure a sustainable performance in business. Noteworthy is the endeavor for the development of a high-level structure for all international standards for management systems, aiming to harmonize these standards to facilitate the implementation of integrated management systems (quality − environment − security − social responsibility.

  14. A comparison of video modeling, text-based instruction, and no instruction for creating multiple baseline graphs in Microsoft Excel.

    Science.gov (United States)

    Tyner, Bryan C; Fienup, Daniel M

    2015-09-01

    Graphing is socially significant for behavior analysts; however, graphing can be difficult to learn. Video modeling (VM) may be a useful instructional method but lacks evidence for effective teaching of computer skills. A between-groups design compared the effects of VM, text-based instruction, and no instruction on graphing performance. Participants who used VM constructed graphs significantly faster and with fewer errors than those who used text-based instruction or no instruction. Implications for instruction are discussed.

  15. Customer satisfaction and business excellence

    DEFF Research Database (Denmark)

    Kristensen, Kai; Martensen, Anne; Grønholdt, Lars

    , customer loyalty and performance, and optimal customer satisfaction is characterized which will help management choose the right quality parameters for improvement. Second, the paper describes empirical evidence that customer satisfaction measures, based on a modelling approach, have impact on economic......The topic for this paper is the link between customer satisfaction and business performance, which makes it possible to use customer satisfaction measures as basis for creating business excellence. First, the paper presents microeconomic models for the relationship between customer satisfaction...

  16. Customer satisfaction and business excellence

    DEFF Research Database (Denmark)

    Kristensen, Kai; Martensen, Anne; Grønholdt, Lars

    The topic for this paper is the link between customer satisfaction and business performance, which makes it possible to use customer satisfaction measures as basis for creating business excellence. First, the paper presents microeconomic models for the relationship between customer satisfaction......, customer loyalty and performance, and optimal customer satisfaction is characterized which will help management choose the right quality parameters for improvement. Second, the paper describes empirical evidence that customer satisfaction measures, based on a modelling approach, have impact on economic...

  17. Vortexlet models of flapping flexible wings show tuning for force production and control

    Energy Technology Data Exchange (ETDEWEB)

    Mountcastle, A M [Department of Organismic and Evolutionary Biology, Harvard University, Concord Field Station, Bedford, MA 01730 (United States); Daniel, T L, E-mail: mtcastle@u.washington.ed [Department of Biology, University of Washington, Seattle, WA 98195 (United States)

    2010-12-15

    Insect wings are compliant structures that experience deformations during flight. Such deformations have recently been shown to substantially affect induced flows, with appreciable consequences to flight forces. However, there are open questions related to the aerodynamic mechanisms underlying the performance benefits of wing deformation, as well as the extent to which such deformations are determined by the boundary conditions governing wing actuation together with mechanical properties of the wing itself. Here we explore aerodynamic performance parameters of compliant wings under periodic oscillations, subject to changes in phase between wing elevation and pitch, and magnitude and spatial pattern of wing flexural stiffness. We use a combination of computational structural mechanics models and a 2D computational fluid dynamics approach to ask how aerodynamic force production and control potential are affected by pitch/elevation phase and variations in wing flexural stiffness. Our results show that lift and thrust forces are highly sensitive to flexural stiffness distributions, with performance optima that lie in different phase regions. These results suggest a control strategy for both flying animals and engineering applications of micro-air vehicles.

  18. SC-535, a Novel Oral Multikinase Inhibitor, Showed Potent Antitumor Activity in Human Melanoma Models

    Directory of Open Access Journals (Sweden)

    Xin Chen

    2013-07-01

    Full Text Available Background: Melanoma is considered as one of the most aggressive and deadliest cancers and current targeted therapies of melanoma often suffer limited efficacy or drug resistance. Discovery of novel multikinase inhibitors as anti-melanoma drug candidates is still needed. Methods: In this investigation, we assessed the in vitro and in vivo anti-melanoma activities of SC-535, which is a novel small molecule multikinase inhibitor discovered by us recently. We analyzed inhibitory effects of SC-535 on various melanoma cell lines and human umbilical vascular endothelial cells (HUVEC in vitro. Tumor xenografts in athymic mice were used to examine the in vivo activity of SC-535. Results: SC-535 could efficiently inhibit vascular endothelial growth factor receptor (VEGFR 1/2/3, B-RAF, and C-RAF kinases. It showed significant antiangiogenic potencies both in vitro and in vivo and considerable anti-proliferative ability against several melanoma cell lines. Oral administration of SC-535 resulted in dose-dependent suppression of tumor growth in WM2664 and C32 xenograft mouse models. Studies of mechanisms of action indicated that SC-535 suppressed the tumor angiogenesis and induced G2/M phase cell cycle arrest in human melanoma cells. SC-535 possesses favorable pharmacokinetic properties. Conclusion: All of these results support SC-535 as a potential candidate for clinical studies in patients with melanoma.

  19. Progesterone Treatment Shows Benefit in Female Rats in a Pediatric Model of Controlled Cortical Impact Injury.

    Directory of Open Access Journals (Sweden)

    Rastafa I Geddes

    Full Text Available We recently showed that progesterone treatment can reduce lesion size and behavioral deficits after moderate-to-severe bilateral injury to the medial prefrontal cortex in immature male rats. Whether there are important sex differences in response to injury and progesterone treatment in very young subjects has not been given sufficient attention. Here we investigated progesterone's effects in the same model of brain injury but with pre-pubescent females.Twenty-eight-day-old female Sprague-Dawley rats received sham (n = 14 or controlled cortical impact (CCI (n = 21 injury, were given progesterone (8 mg/kg body weight or vehicle injections on post-injury days (PID 1-7, and underwent behavioral testing from PID 9-27. Brains were evaluated for lesion size at PID 28.Lesion size in vehicle-treated female rats with CCI injury was smaller than that previously reported for similarly treated age-matched male rats. Treatment with progesterone reduced the effect of CCI on extent of damage and behavioral deficits.Pre-pubescent female rats with midline CCI injury to the frontal cortex have reduced morphological and functional deficits following progesterone treatment. While gender differences in susceptibility to this injury were observed, progesterone treatment produced beneficial effects in young rats of both sexes following CCI.

  20. EROBATIC SHOW

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    Visitors look at plane models of the Commercial Aircraft Corp. of China, developer of the count,s first homegrown large passenger jet C919, during the Singapore Airshow on February 16. The biennial event is the largest airshow in Asia and one of the most important aviation and defense shows worldwide. A number of Chinese companies took part in the event during which Okay Airways, the first privately owned aidine in China, signed a deal to acquire 12 Boeing 737 jets.

  1. Showing a model's eye movements in examples does not improve learning of problem-solving tasks

    NARCIS (Netherlands)

    van Marlen, Tim; van Wermeskerken, Margot; Jarodzka, Halszka; van Gog, Tamara

    2016-01-01

    Eye movement modeling examples (EMME) are demonstrations of a computer-based task by a human model (e.g., a teacher), with the model's eye movements superimposed on the task to guide learners' attention. EMME have been shown to enhance learning of perceptual classification tasks; however, it is an

  2. Showing a model's eye movements in examples does not improve learning of problem-solving tasks

    NARCIS (Netherlands)

    van Marlen, Tim; van Wermeskerken, Margot; Jarodzka, Halszka; van Gog, Tamara

    2016-01-01

    Eye movement modeling examples (EMME) are demonstrations of a computer-based task by a human model (e.g., a teacher), with the model's eye movements superimposed on the task to guide learners' attention. EMME have been shown to enhance learning of perceptual classification tasks; however, it is an o

  3. What Can the Bohr-Sommerfeld Model Show Students of Chemistry in the 21st Century?

    Science.gov (United States)

    Niaz, Mansoor; Cardellini, Liberato

    2011-01-01

    Bohr's model of the atom is considered to be important by general chemistry textbooks. A shortcoming of this model was that it could not explain the spectra of atoms containing more than one electron. To increase the explanatory power of the model, Sommerfeld hypothesized the existence of elliptical orbits. This study aims to elaborate a framework…

  4. Elements of Engineering Excellence

    Science.gov (United States)

    Blair, J. C.; Ryan, R. S.; Schutzenhofer

    2012-01-01

    The inspiration for this Contract Report (CR) originated in discussions with the director of Marshall Space Flight Center (MSFC) Engineering who asked that we investigate the question: "How do you achieve excellence in aerospace engineering?" Engineering a space system is a complex activity. Avoiding its inherent potential pitfalls and achieving a successful product is a challenge. This CR presents one approach to answering the question of how to achieve Engineering Excellence. We first investigated the root causes of NASA major failures as a basis for developing a proposed answer to the question of Excellence. The following discussions integrate a triad of Technical Understanding and Execution, Partnership with the Project, and Individual and Organizational Culture. The thesis is that you must focus on the whole process and its underlying culture, not just on the technical aspects. In addition to the engineering process, emphasis is given to the need and characteristics of a Learning Organization as a mechanism for changing the culture.

  5. The national post-baccalaureate graduate nurse residency program: a model for excellence in transition to practice.

    Science.gov (United States)

    Krugman, Mary; Bretschneider, Joan; Horn, Phyllis B; Krsek, Cathleen A; Moutafis, Roxanne A; Smith, Marion Oare

    2006-01-01

    The Chief Nursing Officers (CNOs) of the University HealthSystems Consortium (UHC) of Academic Hospitals desired to increase the numbers of baccalaureate graduate nurses hired by their facilities and provide a more consistent, uniform transition into practice for these graduate nurses. A partnership between the UHC CNOs and the American Association of Colleges of Nursing (AACN) led to establishing a National Post-Baccalaureate Graduate Nurse Residency Program. The structure, curriculum, and outcomes measures were developed and the program was implemented, with growth from six original pilot sites to 34 academic hospitals. Outcomes from the first year of program operation at these six sites show a high rate of retention, decreased stress by graduate nurses over time, improved organization and prioritization of care, and increased satisfaction in the first year of practice.

  6. Paternity analysis in Excel.

    Science.gov (United States)

    Rocheta, Margarida; Dionísio, F Miguel; Fonseca, Luís; Pires, Ana M

    2007-12-01

    Paternity analysis using microsatellite information is a well-studied subject. These markers are ideal for parentage studies and fingerprinting, due to their high-discrimination power. This type of data is used to assign paternity, to compute the average selfing and outcrossing rates and to estimate the biparental inbreeding. There are several public domain programs that compute all this information from data. Most of the time, it is necessary to export data to some sort of format, feed it to the program and import the output to an Excel book for further processing. In this article we briefly describe a program referred from now on as Paternity Analysis in Excel (PAE), developed at IST and IBET (see the acknowledgments) that computes paternity candidates from data, and other information, from within Excel. In practice this means that the end user provides the data in an Excel sheet and, by pressing an appropriate button, obtains the results in another Excel sheet. For convenience PAE is divided into two modules. The first one is a filtering module that selects data from the sequencer and reorganizes it in a format appropriate to process paternity analysis, assuming certain conventions for the names of parents and offspring from the sequencer. The second module carries out the paternity analysis assuming that one parent is known. Both modules are written in Excel-VBA and can be obtained at the address (www.math.ist.utl.pt/~fmd/pa/pa.zip). They are free for non-commercial purposes and have been tested with different data and against different software (Cervus, FaMoz, and MLTR).

  7. Managing data using Excel

    CERN Document Server

    Gardener, Mark

    2015-01-01

    Microsoft Excel is a powerful tool that can transform the way you use data. This book explains in comprehensive and user-friendly detail how to manage, make sense of, explore and share data, giving scientists at all levels the skills they need to maximize the usefulness of their data. Readers will learn how to use Excel to: * Build a dataset - how to handle variables and notes, rearrangements and edits to data. * Check datasets - dealing with typographic errors, data validation and numerical errors. * Make sense of data - including datasets for regression and correlation; summarizing data

  8. Excel 2010 For Dummies

    CERN Document Server

    Harvey, Greg

    2012-01-01

    Crunch numbers, create spreadsheets, and get up to speed on Excel 2010! This friendly book gets you started with the basics of Excel 2010, such as creating a spreadsheet from scratch, selecting commands from the Ribbon, customizing the Quick Access toolbar, creating simple formulas, moving and copying data with drag and drop, using the AutoCorrect and AutoFill features, and more. Navigate effectively - see how the Ribbon interface and the Backstage View give you access to all the tools you need for every task Be a mover and a shaker - move and copy data with cut, copy, and paste or drag and dr

  9. Searching for excellence

    Science.gov (United States)

    Yager, Robert E.

    Visits to six school districts which were identified by the National Science Teachers Association's Search for Excellence program were made during 1983 by teams of 17 researchers. The reports were analyzed in search for common characteristics that can explain the requirements necessary for excellent science programs. The results indicate that creative ideas, administrative and community involvement, local ownership and pride, and well-developed in-service programs and implementation strategies are vital. Exceptional teachers with boundless energies also seem to exist where exemplary science programs are found.

  10. 略谈服装表演模特的训练方式%On the Training Mode of Fashion Show Models

    Institute of Scientific and Technical Information of China (English)

    潘晓玲

    2014-01-01

    Fashion show is an art of showing a model’s body in certain sense. This paper analyzes how an excellent model shows his or her own unique charm in the T-stage through training mainly from basic physical training; stage performance training and performance experience.%服装表演在某种意义上是展示模特形体的艺术。文章着重阐述了一名优秀的模特如何通过训练在T台上展示自己独特的魅力,主要从基础形体训练、舞台表演训练、表演经验积累3个方面进行了论述。

  11. EDITORIAL AGREEMENT TOWARDS EXCELLENCE

    Directory of Open Access Journals (Sweden)

    Julián A. Herrera M

    2009-06-01

    Full Text Available Colombia Médica was recently classified by COLCIENCIAS in A1 category as a fair recognition by its long undertaking of scientific publication during four decades, achieving articles to be consulted and informed in twenty two international data bases, including Institute for Scientific Information (ISI-Thomson, and having an impact factor (SCIMAGO. All of this is by being devoted to an outstanding quality: excellence.In the beginning Colombia Médica was printed out on paper with one thousand copies quarterly for national distribution and extended exchange requested by libraries from prestigious universities over the world. Web publication of the journal was a decisive step to increase its diffusion at a long scale. International data bases information of reading people show that a very important part of consultation (60% is done over the five continent´s countries surpassing the mean of one thousand consults per day.A journal importance may be measured by its level of contribution to new knowledge, academic debate of highly controversial topics having as central axle scientific contribution frontiers and state of the art, which is reflected by the degree of article quotation in highest level publications. Investigators from twenty countries of three continents have communicated their research contributions in Colombia Médica; this demonstrates and proves the journal visibility both for regular readers and for the international scientific community.La Universidad del Valle is a superior education institution distinguished by national government due to its excellence patterns and classified by SCIMAGO as the Colombian public university of high standing scientific visibility. Institutional support to research, in all dimensions, has made possible to Colombia Médica the development of internal regulations that obey to university structure, maintaining at the same time an editorial independence which preserves its high standards.Colombia M

  12. Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection.

    Science.gov (United States)

    Stec, Jozef; Onajole, Oluseye K; Lun, Shichun; Guo, Haidan; Merenbloom, Benjamin; Vistoli, Giulio; Bishai, William R; Kozikowski, Alan P

    2016-07-14

    Our team had previously identified certain indolecarboxamides that represented a new chemical scaffold that showed promising anti-TB activity at both an in vitro and in vivo level. Based on mutational analysis using bacteria found resistant to one of these indolecarboxamides, we identified the trehalose monomycolate transporter MmpL3 as the likely target of these compounds. In the present work, we now further elaborate on the SAR of these compounds, which has led in turn to the identification of a new analog, 4,6-difluoro-N-((1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)-1H-indole-2-carboxamide (26), that shows excellent activity against drug-sensitive (MIC = 0.012 μM; SI ≥ 16000), multidrug-resistant (MDR), and extensively drug-resistant (XDR) Mycobacterium tuberculosis strains, has superior ADMET properties, and shows excellent activity in the TB aerosol lung infection model. Compound 26 is also shown to work in synergy with rifampin. Because of these properties, we believe that indolecarboxamide 26 is a possible candidate for advancement to human clinical trials.

  13. Enlisting Excel--Again

    Science.gov (United States)

    Parramore, Keith

    2009-01-01

    In Volume 26, Number 2, we reported on a group case study run for level 3 mathematics students at the University of Brighton. At the core of the study was a quadratic assignment problem, and we reported on attempts by students to use Excel to solve the problem, and on the attendant difficulties. We provided an elegant solution. In this article, we…

  14. Excellence in School Science.

    Science.gov (United States)

    Rakow, Steven J.

    1985-01-01

    Lists objectives for excellence/exemplary programs in middle/junior high school science as perceived by a group of middle/junior high school science teachers. These objectives focus on: (1) goals; (2) curricula; (3) instruction; (4) teachers; and (5) evaluation. (JN)

  15. The Guideline Implementability Decision Excellence Model (GUIDE-M): a mixed methods approach to create an international resource to advance the practice guideline field.

    Science.gov (United States)

    Brouwers, Melissa C; Makarski, Julie; Kastner, Monika; Hayden, Leigh; Bhattacharyya, Onil

    2015-03-15

    Practice guideline (PG) implementability refers to PG features that promote their use. While there are tools and resources to promote PG implementability, none are based on an evidence-informed and multidisciplinary perspective. Our objectives were to (i) create a comprehensive and evidence-informed model of PG implementability, (ii) seek support for the model from the international PG community, (iii) map existing implementability tools on to the model, (iv) prioritize areas for further investigation, and (v) describe how the model can be used by PG developers, users, and researchers. A mixed methods approach was used. Using our completed realist review of the literature of seven different disciplines as the foundation, an iterative consensus process was used to create the beta version of the model. This was followed by (i) a survey of international stakeholders (guideline developers and users) to gather feedback and to refine the model, (ii) a content analysis comparing the model to existing PG tools, and (iii) a strategy to prioritize areas of the model for further research by members of the research team. The Guideline Implementability for Decision Excellence Model (GUIDE-M) is comprised of 3 core tactics, 7 domains, 9 subdomains, 44 attributes, and 40 subattributes and elements. Feedback on the beta version was received from 248 stakeholders from 34 countries. The model was rated as logical, relevant, and appropriate. Seven PG tools were selected and compared to the GUIDE-M: very few tools targeted the Contextualization and Deliberations domain. Also, fewer of the tools addressed PG appraisal than PG development and reporting functions. These findings informed the research priorities identified by the team. The GUIDE-M provides an evidence-informed international and multidisciplinary conceptualization of PG implementability. The model can be used by PG developers to help them create more implementable recommendations, by clinicians and other users to help them

  16. WAVECALC: an Excel-VBA spreadsheet to model the characteristics of fully developed waves and their influence on bottom sediments in different water depths

    Science.gov (United States)

    Le Roux, Jacobus P.; Demirbilek, Zeki; Brodalka, Marysia; Flemming, Burghard W.

    2010-10-01

    The generation and growth of waves in deep water is controlled by winds blowing over the sea surface. In fully developed sea states, where winds and waves are in equilibrium, wave parameters may be calculated directly from the wind velocity. We provide an Excel spreadsheet to compute the wave period, length, height and celerity, as well as horizontal and vertical particle velocities for any water depth, bottom slope, and distance below the reference water level. The wave profile and propagation can also be visualized for any water depth, modeling the sea surface change from sinusoidal to trochoidal and finally cnoidal profiles into shallow water. Bedload entrainment is estimated under both the wave crest and the trough, using the horizontal water particle velocity at the top of the boundary layer. The calculations are programmed in an Excel file called WAVECALC, which is available online to authorized users. Although many of the recently published formulas are based on theoretical arguments, the values agree well with several existing theories and limited field and laboratory observations. WAVECALC is a user-friendly program intended for sedimentologists, coastal engineers and oceanographers, as well as marine ecologists and biologists. It provides a rapid means to calculate many wave characteristics required in coastal and shallow marine studies, and can also serve as an educational tool.

  17. Simple solvable energy-landscape model that shows a thermodynamic phase transition and a glass transition.

    Science.gov (United States)

    Naumis, Gerardo G

    2012-06-01

    When a liquid melt is cooled, a glass or phase transition can be obtained depending on the cooling rate. Yet, this behavior has not been clearly captured in energy-landscape models. Here, a model is provided in which two key ingredients are considered in the landscape, metastable states and their multiplicity. Metastable states are considered as in two level system models. However, their multiplicity and topology allows a phase transition in the thermodynamic limit for slow cooling, while a transition to the glass is obtained for fast cooling. By solving the corresponding master equation, the minimal speed of cooling required to produce the glass is obtained as a function of the distribution of metastable states.

  18. Modeled hydrologic metrics show links between hydrology and the functional composition of stream assemblages.

    Science.gov (United States)

    Patrick, Christopher J; Yuan, Lester L

    2017-07-01

    Flow alteration is widespread in streams, but current understanding of the effects of differences in flow characteristics on stream biological communities is incomplete. We tested hypotheses about the effect of variation in hydrology on stream communities by using generalized additive models to relate watershed information to the values of different flow metrics at gauged sites. Flow models accounted for 54-80% of the spatial variation in flow metric values among gauged sites. We then used these models to predict flow metrics in 842 ungauged stream sites in the mid-Atlantic United States that were sampled for fish, macroinvertebrates, and environmental covariates. Fish and macroinvertebrate assemblages were characterized in terms of a suite of metrics that quantified aspects of community composition, diversity, and functional traits that were expected to be associated with differences in flow characteristics. We related modeled flow metrics to biological metrics in a series of stressor-response models. Our analyses identified both drying and base flow instability as explaining 30-50% of the observed variability in fish and invertebrate community composition. Variations in community composition were related to variations in the prevalence of dispersal traits in invertebrates and trophic guilds in fish. The results demonstrate that we can use statistical models to predict hydrologic conditions at bioassessment sites, which, in turn, we can use to estimate relationships between flow conditions and biological characteristics. This analysis provides an approach to quantify the effects of spatial variation in flow metrics using readily available biomonitoring data. © 2017 by the Ecological Society of America.

  19. Reexamination of the State of the Art Cloud Modeling Shows Real Improvements

    Energy Technology Data Exchange (ETDEWEB)

    Muehlbauer, Andreas D.; Grabowski, Wojciech W.; Malinowski, S. P.; Ackerman, Thomas P.; Bryan, George; Lebo, Zachary; Milbrandt, Jason; Morrison, H.; Ovchinnikov, Mikhail; Tessendorf, Sarah; Theriault, Julie M.; Thompson, Gregory

    2013-05-25

    Following up on an almost thirty year long history of International Cloud Modeling Workshops, that started out with a meeting in Irsee, Germany in 1985, the 8th International Cloud Modeling Workshop was held in July 2012 in Warsaw, Poland. The workshop, hosted by the Institute of Geophysics at the University of Warsaw, was organized by Szymon Malinowski and his local team of students and co-chaired by Wojciech Grabowski (NCAR/MMM) and Andreas Muhlbauer (University of Washington). International Cloud Modeling Workshops have been held traditionally every four years typically during the week before the International Conference on Clouds and Precipitation (ICCP) . Rooted in the World Meteorological Organization’s (WMO) weather modification program, the core objectives of the Cloud Modeling Workshop have been centered at the numerical modeling of clouds, cloud microphysics, and the interactions between cloud microphysics and cloud dynamics. In particular, the goal of the workshop is to provide insight into the pertinent problems of today’s state-of-the-art of cloud modeling and to identify key deficiencies in the microphysical representation of clouds in numerical models and cloud parameterizations. In recent years, the workshop has increasingly shifted the focus toward modeling the interactions between aerosols and clouds and provided case studies to investigate both the effects of aerosols on clouds and precipitation as well as the impact of cloud and precipitation processes on aerosols. This time, about 60 (?) scientists from about 10 (?) different countries participated in the workshop and contributed with discussions, oral and poster presentations to the workshop’s plenary and breakout sessions. Several case leaders contributed to the workshop by setting up five observationally-based case studies covering a wide range of cloud types, namely, marine stratocumulus, mid-latitude squall lines, mid-latitude cirrus clouds, Arctic stratus and winter-time orographic

  20. An Excel-lent Card Trick

    Science.gov (United States)

    Zullo, Holly S.

    2011-01-01

    Card tricks based on mathematical principles can be a great way to get students interested in exploring some important mathematical ideas. In this article, the author discusses a simple spreadsheet implementation that shows students why the card trick works and allows them to explore several variations. As an added bonus, students are introduced…

  1. Phenolic Acids from Wheat Show Different Absorption Profiles in Plasma: A Model Experiment with Catheterized Pigs

    DEFF Research Database (Denmark)

    Nørskov, Natalja; Hedemann, Mette Skou; Theil, Peter Kappel

    2013-01-01

    The concentration and absorption of the nine phenolic acids of wheat were measured in a model experiment with catheterized pigs fed whole grain wheat and wheat aleurone diets. Six pigs in a repeated crossover design were fitted with catheters in the portal vein and mesenteric artery to study the ...

  2. Hypothyroidism with scholastic excellence

    Directory of Open Access Journals (Sweden)

    S Salini

    2015-01-01

    Full Text Available A 9-year-old boy had presented with not gaining adequate height with complaints of constipation from 5 years, lethargy and loss of appetite from past 6 months. He was diagnosed to have hypothyroidism with high thyroid antibody levels. Though he was stunted his neurocognition and scholastic performance was excellent as evidenced by his school rank cards. His physical symptoms had improved after thyroxin supplement

  3. 混合影响模型在渔具选择性分析中的Excel VBA实现%Implementation of mixed effect model in selectivity analysis of fishing gears based on Excel VBA

    Institute of Scientific and Technical Information of China (English)

    白伦; 张健

    2013-01-01

    影响渔具选择性的因素包含可控因素和不可控因素,因此混合影响模型成为了渔具选择性研究中分析网次间差异的常用模型,但目前对于这一模型的具体实现方法的讨论较少.本文从混合影响模型在拖网渔具选择性分析中的模型原理出发,通过Excel的VBA编程功能,实现了模型分析的自动化,并实现模型拟合和模型简化及优劣性判断.使用实例分析和对比后发现基于Excel VBA的这一实现方法不仅可快速、简便地进行混合影响的定性和定量分析及简化和比较,而且还有助于了解模型实现的具体方法,进而根据实际需要对模型进行修改和补充,可为今后开展渔具选择性研究提供参考.

  4. Animal Models for Muscular Dystrophy Show Different Patterns of Sarcolemmal Disruption

    OpenAIRE

    1997-01-01

    Genetic defects in a number of components of the dystrophin–glycoprotein complex (DGC) lead to distinct forms of muscular dystrophy. However, little is known about how alterations in the DGC are manifested in the pathophysiology present in dystrophic muscle tissue. One hypothesis is that the DGC protects the sarcolemma from contraction-induced damage. Using tracer molecules, we compared sarcolemmal integrity in animal models for muscular dystrophy and in muscular dystrophy patient samples. Ev...

  5. A Model Lesson: Finland Shows Us What Equal Opportunity Looks Like

    Science.gov (United States)

    Sahlberg, Pasi

    2012-01-01

    International indicators show that Finland has one of the most educated citizenries in the world, provides educational opportunities in an egalitarian manner, and makes efficient use of resources. But at the beginning of the 1990s, education in Finland was nothing special in international terms. The performance of Finnish students on international…

  6. A Murine Model of Candida glabrata Vaginitis Shows No Evidence of an Inflammatory Immunopathogenic Response

    Science.gov (United States)

    Nash, Evelyn E.; Peters, Brian M.; Lilly, Elizabeth A.; Noverr, Mairi C.; Fidel, Paul L.

    2016-01-01

    Candida glabrata is the second most common organism isolated from women with vulvovaginal candidiasis (VVC), particularly in women with uncontrolled diabetes mellitus. However, mechanisms involved in the pathogenesis of C. glabrata-associated VVC are unknown and have not been studied at any depth in animal models. The objective of this study was to evaluate host responses to infection following efforts to optimize a murine model of C. glabrata VVC. For this, various designs were evaluated for consistent experimental vaginal colonization (i.e., type 1 and type 2 diabetic mice, exogenous estrogen, varying inocula, and co-infection with C. albicans). Upon model optimization, vaginal fungal burden and polymorphonuclear neutrophil (PMN) recruitment were assessed longitudinally over 21 days post-inoculation, together with vaginal concentrations of IL-1β, S100A8 alarmin, lactate dehydrogenase (LDH), and in vivo biofilm formation. Consistent and sustained vaginal colonization with C. glabrata was achieved in estrogenized streptozotocin-induced type 1 diabetic mice. Vaginal PMN infiltration was consistently low, with IL-1β, S100A8, and LDH concentrations similar to uninoculated mice. Biofilm formation was not detected in vivo, and co-infection with C. albicans did not induce synergistic immunopathogenic effects. This data suggests that experimental vaginal colonization of C. glabrata is not associated with an inflammatory immunopathogenic response or biofilm formation. PMID:26807975

  7. The PROMETHEUS bundled payment experiment: slow start shows problems in implementing new payment models.

    Science.gov (United States)

    Hussey, Peter S; Ridgely, M Susan; Rosenthal, Meredith B

    2011-11-01

    Fee-for-service payment is blamed for many of the problems observed in the US health care system. One of the leading alternative payment models proposed in the Affordable Care Act of 2010 is bundled payment, which provides payment for all of the care a patient needs over the course of a defined clinical episode, instead of paying for each discrete service. We evaluated the initial "road test" of PROMETHEUS Payment, one of several bundled payment pilot projects. The project has faced substantial implementation challenges, and none of the three pilot sites had executed contracts or made bundled payments as of May 2011. The pilots have taken longer to set up than expected, primarily because of the complexity of the payment model and the fact that it builds on the existing fee-for-service payment system and other complexities of health care. Participants continue to see promise and value in the bundled payment model, but the pilot results suggest that the desired benefits of this and other payment reforms may take time and considerable effort to materialize.

  8. A Murine Model of Candida glabrata Vaginitis Shows No Evidence of an Inflammatory Immunopathogenic Response.

    Directory of Open Access Journals (Sweden)

    Evelyn E Nash

    Full Text Available Candida glabrata is the second most common organism isolated from women with vulvovaginal candidiasis (VVC, particularly in women with uncontrolled diabetes mellitus. However, mechanisms involved in the pathogenesis of C. glabrata-associated VVC are unknown and have not been studied at any depth in animal models. The objective of this study was to evaluate host responses to infection following efforts to optimize a murine model of C. glabrata VVC. For this, various designs were evaluated for consistent experimental vaginal colonization (i.e., type 1 and type 2 diabetic mice, exogenous estrogen, varying inocula, and co-infection with C. albicans. Upon model optimization, vaginal fungal burden and polymorphonuclear neutrophil (PMN recruitment were assessed longitudinally over 21 days post-inoculation, together with vaginal concentrations of IL-1β, S100A8 alarmin, lactate dehydrogenase (LDH, and in vivo biofilm formation. Consistent and sustained vaginal colonization with C. glabrata was achieved in estrogenized streptozotocin-induced type 1 diabetic mice. Vaginal PMN infiltration was consistently low, with IL-1β, S100A8, and LDH concentrations similar to uninoculated mice. Biofilm formation was not detected in vivo, and co-infection with C. albicans did not induce synergistic immunopathogenic effects. This data suggests that experimental vaginal colonization of C. glabrata is not associated with an inflammatory immunopathogenic response or biofilm formation.

  9. Turn-Taking Model in the Chinese Recruitment Reality show-BelongtoYou

    Institute of Scientific and Technical Information of China (English)

    AI Fan-qing

    2014-01-01

    Based on the theories of conversational analysis proposed by Sacks et al,this paper chooses excerpts of candidates’inter-view from the Chinese recruitment reality TV show BelongtoYou in Tianjin TV. Through analyzing the excerpt, how the rules of turn-taking are applied in this program will be demonstrated. And the features of turn-taking strategies used by the host,candi-dates and bosses will be concluded.

  10. Global thermal niche models of two European grasses show high invasion risks in Antarctica.

    Science.gov (United States)

    Pertierra, Luis R; Aragón, Pedro; Shaw, Justine D; Bergstrom, Dana M; Terauds, Aleks; Olalla-Tárraga, Miguel Ángel

    2016-12-14

    The two non-native grasses that have established long-term populations in Antarctica (Poa pratensis and Poa annua) were studied from a global multidimensional thermal niche perspective to address the biological invasion risk to Antarctica. These two species exhibit contrasting introduction histories and reproductive strategies and represent two referential case studies of biological invasion processes. We used a multistep process with a range of species distribution modelling techniques (ecological niche factor analysis, multidimensional envelopes, distance/entropy algorithms) together with a suite of thermoclimatic variables, to characterize the potential ranges of these species. Their native bioclimatic thermal envelopes in Eurasia, together with the different naturalized populations across continents, were compared next. The potential niche of P. pratensis was wider at the cold extremes; however, P. annua life history attributes enable it to be a more successful colonizer. We observe that particularly cold summers are a key aspect of the unique Antarctic environment. In consequence, ruderals such as P. annua can quickly expand under such harsh conditions, whereas the more stress-tolerant P. pratensis endures and persist through steady growth. Compiled data on human pressure at the Antarctic Peninsula allowed us to provide site-specific biosecurity risk indicators. We conclude that several areas across the region are vulnerable to invasions from these and other similar species. This can only be visualized in species distribution models (SDMs) when accounting for founder populations that reveal nonanalogous conditions. Results reinforce the need for strict management practices to minimize introductions. Furthermore, our novel set of temperature-based bioclimatic GIS layers for ice-free terrestrial Antarctica provide a mechanism for regional and global species distribution models to be built for other potentially invasive species.

  11. A new bovine conjunctiva model shows that Listeria monocytogenes invasion is associated with lysozyme resistance.

    Science.gov (United States)

    Warren, Jessica; Owen, A Rhys; Glanvill, Amy; Francis, Asher; Maboni, Grazieli; Nova, Rodrigo J; Wapenaar, Wendela; Rees, Catherine; Tötemeyer, Sabine

    2015-08-31

    Listerial keratoconjunctivitis ('silage eye') is a wide spread problem in ruminants causing economic losses to farmers and impacts negatively on animal welfare. It results from direct entry of Listeria monocytogenes into the eye, often following consumption of contaminated silage. An isolation protocol for bovine conjunctival swabbing was developed and used to sample both infected and healthy eyes bovine eyes (n=46). L. monocytogenes was only isolated from one healthy eye sample, and suggests that this organism can be present without causing disease. To initiate a study of this disease, an infection model was developed using isolated conjunctiva explants obtained from cattle eyes post slaughter. Conjunctiva were cultured and infected for 20 h with a range of L. monocytogenes isolates (n=11), including the healthy bovine eye isolate and also strains isolated from other bovine sources, such as milk or clinical infections. Two L. monocytogenes isolates (one from a healthy eye and one from a cattle abortion) were markedly less able to invade conjunctiva explants, but one of those was able to efficiently infect Caco2 cells indicating that it was fully virulent. These two isolates were also significantly more sensitive to lysozyme compared to most other isolates tested, suggesting that lysozyme resistance is an important factor when infecting bovine conjunctiva. In conclusion, we present the first bovine conjunctiva explant model for infection studies and demonstrate that clinical L. monocytogenes isolates from cases of bovine keratoconjunctivitis are able to infect these tissues.

  12. Progesterone treatment shows benefit in a pediatric model of moderate to severe bilateral brain injury.

    Directory of Open Access Journals (Sweden)

    Rastafa I Geddes

    Full Text Available PURPOSE: Controlled cortical impact (CCI models in adult and aged Sprague-Dawley (SD rats have been used extensively to study medial prefrontal cortex (mPFC injury and the effects of post-injury progesterone treatment, but the hormone's effects after traumatic brain injury (TBI in juvenile animals have not been determined. In the present proof-of-concept study we investigated whether progesterone had neuroprotective effects in a pediatric model of moderate to severe bilateral brain injury. METHODS: Twenty-eight-day old (PND 28 male Sprague Dawley rats received sham (n = 24 or CCI (n = 47 injury and were given progesterone (4, 8, or 16 mg/kg per 100 g body weight or vehicle injections on post-injury days (PID 1-7, subjected to behavioral testing from PID 9-27, and analyzed for lesion size at PID 28. RESULTS: The 8 and 16 mg/kg doses of progesterone were observed to be most beneficial in reducing the effect of CCI on lesion size and behavior in PND 28 male SD rats. CONCLUSION: Our findings suggest that a midline CCI injury to the frontal cortex will reliably produce a moderate TBI comparable to what is seen in the adult male rat and that progesterone can ameliorate the injury-induced deficits.

  13. V OLATILEC ALC: a silicate melt-H 2O-CO 2 solution model written in Visual Basic for excel

    Science.gov (United States)

    Newman, Sally; Lowenstern, Jacob B.

    2002-06-01

    We present solution models for the rhyolite-H 2O-CO 2 and basalt-H 2O-CO 2 systems at magmatic temperatures and pressures below ˜5000 bar. The models are coded as macros written in Visual Basic for Applications, for use within Microsoft ® Excel (Office'98 and 2000). The series of macros, entitled V OLATILEC ALC, can calculate the following: (1) Saturation pressures for silicate melt of known dissolved H 2O and CO 2 concentrations and the corresponding equilibrium vapor composition; (2) open- and closed-system degassing paths (melt and vapor composition) for depressurizing rhyolitic and basaltic melts; (3) isobaric solubility curves for rhyolitic and basaltic melts; (4) isoplethic solubility curves (constant vapor composition) for rhyolitic and basaltic melts; (5) polybaric solubility curves for the two end members and (6) end member fugacities of H 2O and CO 2 vapors at magmatic temperatures. The basalt-H 2O-CO 2 macros in V OLATILEC ALC are capable of calculating melt-vapor solubility over a range of silicate-melt compositions by using the relationships provided by Dixon (American Mineralogist 82 (1997) 368). The output agrees well with the published solution models and experimental data for silicate melt-vapor systems for pressures below 5000 bar.

  14. A model SN2 reaction ‘on water’ does not show rate enhancement

    Science.gov (United States)

    Nelson, Katherine V.; Benjamin, Ilan

    2011-05-01

    Molecular dynamics calculations of the benchmark nucleophilic substitution reaction (SN2) Cl- + CH3Cl are carried out at the water liquid/vapor interface. The reaction free energy profile and the activation free energy are determined as a function of the reactants' location normal to the surface. The activation free energy remains almost constant relative to that in bulk water, despite the fact that the barrier is expected to significantly decrease as the reaction is carried out near the vapor phase. We show that this is due to the combined effects of a clustering of water molecules around the nucleophile and a relatively weak hydration of the transition state.

  15. In vitro and in vivo models of Huntington's disease show alterations in the endocannabinoid system.

    Science.gov (United States)

    Bari, Monica; Battista, Natalia; Valenza, Marta; Mastrangelo, Nicolina; Malaponti, Marinella; Catanzaro, Giuseppina; Centonze, Diego; Finazzi-Agrò, Alessandro; Cattaneo, Elena; Maccarrone, Mauro

    2013-07-01

    In this study, we analyzed the components of the endocannabinoid system (ECS) in R6/2 mice, a widely used model of Huntington's disease (HD). We measured the endogenous content of N-arachidonoylethanolamine and 2-arachidonoylglycerol and the activity of their biosynthetic enzymes (N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D and diacylglycerol lipase, respectively) and hydrolytic enzymes [fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase, respectively] and of their target receptors (type 1 cannabinoid receptor, type 2 cannabinoid receptor, and transient receptor potential vanilloid-1) in the brains of wild-type and R6/2 mice of different ages, as well as in the striatum and cortex of 12-week-old animals. In addition, we measured FAAH activity in lymphocytes of R6/2 mice. In the whole brains of 12-week-old R6/2 mice, we found reductions in N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D activity, diacylglycerol lipase activity and cannabinoid receptor binding, mostly associated with changes in the striatum but not in the cortex, as well as an increase in 2-arachidonoylglycerol content as compared with wild-type littermates, without any other change in ECS elements. Then, our analysis was extended to HD43 cells, an inducible cellular model of HD derived from rat ST14A cells. In both induced and noninduced conditions, we demonstrated a fully functional ECS. Overall, our data suggest that the ECS is differently affected in mouse and human HD, and that HD43 cells are suitable for high-throughput screening of FAAH-oriented drugs affecting HD progression.

  16. Excel 2013 power programming with VBA

    CERN Document Server

    Walkenbach, John

    2013-01-01

    Maximize your Excel 2013 experience using VBA application development The new Excel 2013 boasts updated features, enhanced power, and new capabilities. Naturally, that means John Walkenbach returns with a new edition of his bestselling VBA Programming book and covers all the methods and tools you need to know in order to program with Excel. With this comprehensive guide, ""Mr. Spreadsheet"" shows you how to maximize your Excel experience using professional spreadsheet application development tips from his own personal bookshelf. Featuring a complete introduction to Visual Basic f

  17. A zebrafish model of glucocorticoid resistance shows serotonergic modulation of the stress response

    Directory of Open Access Journals (Sweden)

    Brian eGriffiths

    2012-10-01

    Full Text Available One function of glucocorticoids is to restore homeostasis after an acute stress response by providing negative feedback to stress circuits in the brain. Loss of this negative feedback leads to elevated physiological stress and may contribute to depression, anxiety and post-traumatic stress disorder. We investigated the early, developmental effects of glucocorticoid signaling deficits on stress physiology and related behaviors using a mutant zebrafish, grs357, with non-functional glucocorticoid receptors. These mutants are morphologically inconspicuous and adult-viable. A previous study of adult grs357 mutants showed loss of glucocorticoid-mediated negative feedback and elevated physiological and behavioral stress markers. Already at five days post-fertilization, mutant larvae had elevated whole body cortisol, increased expression of pro-opiomelanocortin (POMC, the precursor of adrenocorticotropic hormone (ACTH, and failed to show normal suppression of stress markers after dexamethasone treatment. Mutant larvae had larger auditory-evoked startle responses compared to wildtype sibling controls (grwt, despite having lower spontaneous activity levels. Fluoxetine (Prozac treatment in mutants decreased startle responding and increased spontaneous activity, making them behaviorally similar to wildtype. This result mirrors known effects of selective serotonin reuptake inhibitors (SSRIs in modifying glucocorticoid signaling and alleviating stress disorders in human patients. Our results suggest that larval grs357 zebrafish can be used to study behavioral, physiological and molecular aspects of stress disorders. Most importantly, interactions between glucocorticoid and serotonin signaling appear to be highly conserved among vertebrates, suggesting deep homologies at the neural circuit level and opening up new avenues for research into psychiatric conditions.

  18. The atherogenic Scarb1 null mouse model shows a high bone mass phenotype.

    Science.gov (United States)

    Martineau, Corine; Martin-Falstrault, Louise; Brissette, Louise; Moreau, Robert

    2014-01-01

    Scavenger receptor class B, type I (SR-BI), the Scarb1 gene product, is a receptor associated with cholesteryl ester uptake from high-density lipoproteins (HDL), which drives cholesterol movement from peripheral tissues toward the liver for excretion, and, consequently, Scarb1 null mice are prone to atherosclerosis. Because studies have linked atherosclerosis incidence with osteoporosis, we characterized the bone metabolism in these mice. Bone morphometry was assessed through microcomputed tomography and histology. Marrow stromal cells (MSCs) were used to characterize influence of endogenous SR-BI in cell functions. Total and HDL-associated cholesterol in null mice were increased by 32-60%, correlating with its role in lipoprotein metabolism. Distal metaphyses from 2- and 4-mo-old null mice showed correspondingly 46 and 37% higher bone volume fraction associated with a higher number of trabeculae. Histomorphometric analyses in 2-mo-old null male mice revealed 1.42-fold greater osteoblast surface, 1.37-fold higher percent mineralizing surface, and 1.69-fold enhanced bone formation rate. In vitro assays for MSCs from null mice revealed 37% higher proliferation rate, 48% more alkaline phosphatase activity, 70% greater mineralization potential and a 2-fold osterix (Sp7) expression, yet a 0.5-fold decrease in caveolin-1 (Cav1) expression. Selective uptake levels of HDL-associated cholesteryl oleate and estradiol were similar between MSC from wild-type and Scarb1 null mice, suggesting that its contribution to this process is not its main role in these cells. However, Scarb1 knockout stunted the HDL-dependent regulation of Cav1 genic expression. Scarb1 null mice are not prone to osteoporosis but show higher bone mass associated with enhanced bone formation.

  19. NMR Metabolomics Show Evidence for Mitochondrial Oxidative Stress in a Mouse Model of Polycystic Ovary Syndrome.

    Science.gov (United States)

    Selen, Ebru Selin; Bolandnazar, Zeinab; Tonelli, Marco; Bütz, Daniel E; Haviland, Julia A; Porter, Warren P; Assadi-Porter, Fariba M

    2015-08-07

    Polycystic ovary syndrome (PCOS) is associated with metabolic and endocrine disorders in women of reproductive age. The etiology of PCOS is still unknown. Mice prenatally treated with glucocorticoids exhibit metabolic disturbances that are similar to those seen in women with PCOS. We used an untargeted nuclear magnetic resonance (NMR)-based metabolomics approach to understand the metabolic changes occurring in the plasma and kidney over time in female glucocorticoid-treated (GC-treated) mice. There are significant changes in plasma amino acid levels (valine, tyrosine, and proline) and their intermediates (2-hydroxybutyrate, 4-aminobutyrate, and taurine), whereas in kidneys, the TCA cycle metabolism (citrate, fumarate, and succinate) and the pentose phosphate (PP) pathway products (inosine and uracil) are significantly altered (p metabolic substrates in the plasma and kidneys of treated mice are associated with altered amino acid metabolism, increased cytoplasmic PP, and increased mitochondrial activity, leading to a more oxidized state. This study identifies biomarkers associated with metabolic dysfunction in kidney mitochondria of a prenatal gluococorticoid-treated mouse model of PCOS that may be used as early predictive biomarkers of oxidative stress in the PCOS metabolic disorder in women.

  20. Metabolic remodeling agents show beneficial effects in the dystrophin-deficient mdx mouse model

    Directory of Open Access Journals (Sweden)

    Jahnke Vanessa E

    2012-08-01

    Full Text Available Abstract Background Duchenne muscular dystrophy is a genetic disease involving a severe muscle wasting that is characterized by cycles of muscle degeneration/regeneration and culminates in early death in affected boys. Mitochondria are presumed to be involved in the regulation of myoblast proliferation/differentiation; enhancing mitochondrial activity with exercise mimetics (AMPK and PPAR-delta agonists increases muscle function and inhibits muscle wasting in healthy mice. We therefore asked whether metabolic remodeling agents that increase mitochondrial activity would improve muscle function in mdx mice. Methods Twelve-week-old mdx mice were treated with two different metabolic remodeling agents (GW501516 and AICAR, separately or in combination, for 4 weeks. Extensive systematic behavioral, functional, histological, biochemical, and molecular tests were conducted to assess the drug(s' effects. Results We found a gain in body and muscle weight in all treated mice. Histologic examination showed a decrease in muscle inflammation and in the number of fibers with central nuclei and an increase in fibers with peripheral nuclei, with significantly fewer activated satellite cells and regenerating fibers. Together with an inhibition of FoXO1 signaling, these results indicated that the treatments reduced ongoing muscle damage. Conclusions The three treatments produced significant improvements in disease phenotype, including an increase in overall behavioral activity and significant gains in forelimb and hind limb strength. Our findings suggest that triggering mitochondrial activity with exercise mimetics improves muscle function in dystrophin-deficient mdx mice.

  1. Male Wistar rats show individual differences in an animal model of conformity.

    Science.gov (United States)

    Jolles, Jolle W; de Visser, Leonie; van den Bos, Ruud

    2011-09-01

    Conformity refers to the act of changing one's behaviour to match that of others. Recent studies in humans have shown that individual differences exist in conformity and that these differences are related to differences in neuronal activity. To understand the neuronal mechanisms in more detail, animal tests to assess conformity are needed. Here, we used a test of conformity in rats that has previously been evaluated in female, but not male, rats and assessed the nature of individual differences in conformity. Male Wistar rats were given the opportunity to learn that two diets differed in palatability. They were subsequently exposed to a demonstrator that had consumed the less palatable food. Thereafter, they were exposed to the same diets again. Just like female rats, male rats decreased their preference for the more palatable food after interaction with demonstrator rats that had eaten the less palatable food. Individual differences existed for this shift, which were only weakly related to an interaction between their own initial preference and the amount consumed by the demonstrator rat. The data show that this conformity test in rats is a promising tool to study the neurobiology of conformity.

  2. Drag—An EXCEL visual basic program for modeling fault drag using cubic splines and calculation of minimum dip and strike separation

    Science.gov (United States)

    Ozkaya, S. I.; Mattner, J.

    1996-06-01

    An EXCEL visual basic program is presented for modeling fault drag using cubic splines. The objective of the program is to estimate minimum dip and strike separation using dip measurements in the vicinity of a fault. The program is useful especially for estimating stratigraphic separation in the subsurface environment where only limited structural information is available from dipmeter logs. A modified cubic spline curve fitting procedure is used to model bedding trace within the fault drag zone. The solution procedure is based on the assumption that the dip angle is the same at equal distances away from the fault trace on a cross-section or map projection within the fault drag zone on the same side of the fault. On a cross-section perpendicular to the strike of a fault, the distance between the points of intersection of the fault trace with dragged bed and projection of the undisturbed bed gives half of the minimum dip separation. On a map projection, this distance is equal to half of the strike separation.

  3. Excel 2010 Workbook for Dummies

    CERN Document Server

    Harvey, Greg

    2010-01-01

    Reinforce your understanding of Excel with these Workbook exercises. Boost your knowledge of important Excel tasks by putting your skills to work in real-world situations. The For Dummies Workbook format provides more than 100 exercises that help you create actual results with Excel so you can gain proficiency. Perfect for students, people learning Excel on their own, and financial professionals who must plan and execute complex projects in Excel, Excel 2010 Workbook For Dummies helps you discover all the ways this program can work for you.: Excel is the world's most popular number-crunching p

  4. The Quest for Educational Excellence

    Directory of Open Access Journals (Sweden)

    Kathleen A. Tobin

    2015-04-01

    Full Text Available A review of the book “The Global Fourth Way: The Quest for Educational Excellence.” By Andy Hargreaves and Dennis Shirley. Thousand Oaks, CA: Corwin, 2012. ISBN: 978-1412987868 Individual chapters in The Global Fourth Way center on examples of high performance in Finland, Singapore, Alberta (Canada, Ontario (Canada, England, and California (US. Each captures the essence of educational models, practices, and issues in the region at large, before focusing on specific cases that support key values in their proposal.

  5. Excel-Based Business Analysis

    CERN Document Server

    Anari, Ali

    2012-01-01

    ai"The trend is your friend"is a practical principle often used by business managers, who seek to forecast future sales, expenditures, and profitability in order to make production and other operational decisions. The problem is how best to identify and discover business trends and utilize trend information for attaining objectives of firms.This book contains an Excel-based solution to this problem, applying principles of the authors' "profit system model" of the firm that enables forecasts of trends in sales, expenditures, profits and other business variables. The program,

  6. Men and women with bisexual identities show bisexual patterns of sexual attraction to male and female "swimsuit models".

    Science.gov (United States)

    Lippa, Richard A

    2013-02-01

    Do self-identified bisexual men and women actually show bisexual patterns of sexual attraction and interest? To answer this question, I studied bisexual men's and women's sexual attraction to photographed male and female "swimsuit models" that varied in attractiveness. Participants (663 college students and gay pride attendees, including 14 self-identified bisexual men and 17 self-identified bisexual women) rated their degree of sexual attraction to 34 male and 34 female swimsuit models. Participants' viewing times to models were unobtrusively assessed. Results showed that bisexual men and women showed bisexual patterns of attraction and viewing times to photo models, which strongly distinguished them from same-sex heterosexual and homosexual participants. In contrast to other groups, which showed evidence of greater male than female category specificity, bisexual men and women did not differ in category specificity. Results suggest that there are subsets of men and women who display truly bisexual patterns of sexual attraction and interest.

  7. Determinants of Excellent Kindergarten Learning of Excellent Pupils

    NARCIS (Netherlands)

    Dijkstra, Elma; Mooij, Ton; Kirschner, Paul A.

    2013-01-01

    Dijkstra, E. M., Mooij, T., & Kirschner, P. A. (2013, 27 August). Determinants of Excellent Kindergarten Learning of Excellent Pupils. In J. Kornmann (Chair), Cognitive Abilities and Instructional Designs. Symposium conducted at the EARLI 2013 conference, Munich, Germany.

  8. Show Time

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正> Story: Show Time!The whole class presents the story"Under the Sea".Everyone is so excited and happy.Both Leo and Kathy show their parentsthe characters of the play."Who’s he?"asks Kathy’s mom."He’s the prince."Kathy replies."Who’s she?"asks Leo’s dad."She’s the queen."Leo replieswith a smile.

  9. Snobbish Show

    Institute of Scientific and Technical Information of China (English)

    YIN PUMIN

    2010-01-01

    @@ The State Administration of Radio,Film and Television (SARFT),China's media watchdog,issued a new set of mles on June 9 that strictly regulate TV match-making shows,which have been sweeping the country's primetime programming. "Improper social and love values such as money worship should not be presented in these shows.Humiliation,verbal attacks and sex-implied vulgar content are not allowed" the new roles said.

  10. 我国医疗卫生组织应用卓越绩效模式的实践与探讨%Study on the application of performance excellence model in Chinese med-ical and health organization

    Institute of Scientific and Technical Information of China (English)

    郑杰; 赵雪竹; 张金玉; 杨红; 王潇; 王志伟

    2014-01-01

    卓越绩效模式是一种组织综合绩效管理的有效方法和工具,在世界数十个国家和地区的数千家组织中得以应用并取得了良好效果,已成为追求卓越绩效表现的国际标准并被广泛认可。在医改中引入卓越绩效模式有助于改善医疗卫生体系绩效。本文介绍了卓越绩效模式的概念、独特性以及医疗卫生组织应用卓越绩效模式的意义,对卓越绩效模式在国内外医疗卫生组织中的应用情况进行比较分析。目前卓越绩效模式在国内医疗卫生组织的应用较少,卓越绩效模式还未能充分发挥其潜力。国内卓越绩效评审应进一步明确对医疗卫生组织的导向,加强制度保障和组织管理,促进卓越绩效模式在医疗卫生组织中的应用。%The performance excellence model is an effective method and tool for comprehensive performance manage-ment, which has been extremely successful in promoting performance excellence of thousands of organizations across many countries and regions around the world, it has truly become accepted as a global benchmark and worldwide stan-dard for performance excellence. Implementing the performance excellence model as part of healthcare reform can as-sist in transforming healthcare systems to achieve positive outcomes. This paper introduces the concept, uniqueness, application value and practical significance, application of performance excellence model in health care organizations at home and abroad. At present, the application of performance excellence model in the domestic health care organizations is insufficient, that is performance excellence model failed to reach its full potential. The appraisal about performance excellence model should definite the orientation of health care organizations, which is helpful to promote the advanced idea and the management method of performance excellence model.

  11. Plot showing ATLAS limits on Standard Model Higgs production in the mass range 110-150 GeV

    CERN Multimedia

    ATLAS Collaboration

    2011-01-01

    The combined upper limit on the Standard Model Higgs boson production cross section divided by the Standard Model expectation as a function of mH is indicated by the solid line. This is a 95% CL limit using the CLs method in in the low mass range. The dotted line shows the median expected limit in the absence of a signal and the green and yellow bands reflect the corresponding 68% and 95% expected

  12. Plot showing ATLAS limits on Standard Model Higgs production in the mass range 100-600 GeV

    CERN Multimedia

    ATLAS Collaboration

    2011-01-01

    The combined upper limit on the Standard Model Higgs boson production cross section divided by the Standard Model expectation as a function of mH is indicated by the solid line. This is a 95% CL limit using the CLs method in the entire mass range. The dotted line shows the median expected limit in the absence of a signal and the green and yellow bands reflect the corresponding 68% and 95% expected

  13. Idea of Quality Versus Idea of Excellence

    Directory of Open Access Journals (Sweden)

    Marko Kiauta

    2012-12-01

    Full Text Available This study investigates professionals on the field of quality, are responsible to give to customer honest clarification of fundamental ideas. Quality movement is losing credibility with suggesting that the idea of quality is replacing with the idea of excellence. Findings are based on more than 25 years of practice in professional promotion of quality: in consulting on private and public sector, from 1990 lead auditor at SIQ (Slovenian Institute of Quality, from 1998 lead assessor – commission for Slovenian Excellence Quality Award. Theory is developed based on: Noriaki Kano theory of Attractive quality, Tito Conti ideas on TQM and applications problems of Excellence model, Practical case of General Hospital Novo Mesto (in 1998 first attempt of using EM, than forced to build QMS based on ISO 9001 and then returned to practice EM. Findings: We really need to amplify and to understand the concept of quality in a much wider way. To treat excellence related activities separated from all others quality management activities is not god solution. The name of EFQM Excellence Model should be replaced with Quality Management Model. Research limitations/implications: This paper present findings mainly based on practice in Slovenia and especially in public sector where practicing of CAF is not giving expected benefits. Practical implications: The three styles of quality management (improvements to reach demands, improvements to reach expectations, improvements to react on new conditions and needs should be connected with personal development. Theory is developed based on: Noriaki Kano theory of Attractive quality, Tito Conti ideas on TQM and applications problems of Excellence model. We need integration moments. Integration is other word for creativity and health. It leads to integrity. Excellence is only one of three states of quality. If we ask: How? The answer is bad, good or excellent. All three are possible states of the same parameter.

  14. Statistical analysis with Excel for dummies

    CERN Document Server

    Schmuller, Joseph

    2013-01-01

    Take the mystery out of statistical terms and put Excel to work! If you need to create and interpret statistics in business or classroom settings, this easy-to-use guide is just what you need. It shows you how to use Excel's powerful tools for statistical analysis, even if you've never taken a course in statistics. Learn the meaning of terms like mean and median, margin of error, standard deviation, and permutations, and discover how to interpret the statistics of everyday life. You'll learn to use Excel formulas, charts, PivotTables, and other tools to make sense of everything fro

  15. 101 Ready-To-Use Excel Macros

    CERN Document Server

    Alexander, Michael

    2012-01-01

    Save time and be more productive with this helpful guide to Excel macros! While most books about Excel macros offer only minor examples, usually aimed at illustrating a particular topic, this invaluable resource provides you with the tools needed to efficiently and effectively program Excel macros immediately. Step-by-step instructions show you how to create VBA macros and explain how to customize your applications to look and work exactly as you want them to. By the end of the book, you will understand how each featured macro works, be able to reuse the macros included in the book and online,

  16. EXCEL VBA的动态数据透视表及结合差分建模技术在医院统计工作中的应用%Application of EXCEL VBA Based Dynamic PivotTable Integrated with Difference Modeling for Hospital Accounting

    Institute of Scientific and Technical Information of China (English)

    赵峰

    2007-01-01

    利用EXCEL VBA自动控制数据透视表结合SpreadSheet法差分建模技术,从科学、高效、实用的角度出发判别分析医院统计数据的性态,既弥补了现行HIS在统计预测分析等方面的不足,又能快速有效的提高医院统计工作质量.Application of EXCEL VBA Based Dynamic PivotTable Integrated with Difference Modeling for Hospital Accounting /Feng ZHAO// China Digital Medicine. -2007,2 (6): 39 to 40

  17. Hill-type muscle model parameters determined from experiments on single muscles show large animal-to-animal variation.

    Science.gov (United States)

    Blümel, Marcus; Guschlbauer, Christoph; Daun-Gruhn, Silvia; Hooper, Scott L; Büschges, Ansgar

    2012-11-01

    Models built using mean data can represent only a very small percentage, or none, of the population being modeled, and produce different activity than any member of it. Overcoming this "averaging" pitfall requires measuring, in single individuals in single experiments, all of the system's defining characteristics. We have developed protocols that allow all the parameters in the curves used in typical Hill-type models (passive and active force-length, series elasticity, force-activation, force-velocity) to be determined from experiments on individual stick insect muscles (Blümel et al. 2012a). A requirement for means to not well represent the population is that the population shows large variation in its defining characteristics. We therefore used these protocols to measure extensor muscle defining parameters in multiple animals. Across-animal variability in these parameters can be very large, ranging from 1.3- to 17-fold. This large variation is consistent with earlier data in which extensor muscle responses to identical motor neuron driving showed large animal-to-animal variability (Hooper et al. 2006), and suggests accurate modeling of extensor muscles requires modeling individual-by-individual. These complete characterizations of individual muscles also allowed us to test for parameter correlations. Two parameter pairs significantly co-varied, suggesting that a simpler model could as well reproduce muscle response.

  18. Striving for Excellence

    DEFF Research Database (Denmark)

    Hattke, Fabian; Blaschke, Steffen

    2015-01-01

    public universities from 2008-2013. Multiple-regression analysis is applied to test the hypotheses. Findings: - Our results indicate that disciplinary and educational diversity of upper echelons has a positive effect on the outcomes. Other top management team characteristics (age, gender, etc.) show...

  19. Contribution of Lean Management to Excellence

    Directory of Open Access Journals (Sweden)

    López-Fresno Palmira

    2014-11-01

    Full Text Available To continuously and systematically improve efficiency and efficacy of processes, organizations need the implication of all employees in continuous improvement and innovation through suitable Quality Management Programs (QMPs. Effectiveness of these programs is directly linked to the requirement employees understand the methodologies and tools used for QM and the benefits that will derivate from their implementation, individually and collectively, so they can commit and implicate. Lean Management is a friendly methodology to continuously and systematically achieve process improvement, so helping the organization seeking operational excellence that contributes to overall excellence. This paper identifies Critical Success Factors (CSFs for an effective implementation of QMPs, suggests Lean Management as an easy-to-understand, powerful and friendly methodology for operational excellence and overall excellence, and presents a case experience of implementation of Lean Management in a health care organization that applies the EFQM model, and the lessons learnt.

  20. Plectasin shows intracellular activity against Staphylococcus aureus in human THP-1 monocytes and in a mouse peritonitis model

    DEFF Research Database (Denmark)

    Brinch, Karoline Sidelmann; Sandberg, Anne; Baudoux, Pierre

    2009-01-01

    was maintained (maximal relative efficacy [E(max)], 1.0- to 1.3-log reduction in CFU) even though efficacy was inferior to that of extracellular killing (E(max), >4.5-log CFU reduction). Animal studies included a novel use of the mouse peritonitis model, exploiting extra- and intracellular differentiation assays...... concentration. These findings stress the importance of performing studies of extra- and intracellular activity since these features cannot be predicted from traditional MIC and killing kinetic studies. Application of both the THP-1 and the mouse peritonitis models showed that the in vitro results were similar...

  1. Excel VBA 24-hour trainer

    CERN Document Server

    Urtis, Tom

    2015-01-01

    Master VBA automation quickly and easily to get more out of Excel Excel VBA 24-Hour Trainer, 2nd Edition is the quick-start guide to getting more out of Excel, using Visual Basic for Applications. This unique book/video package has been updated with fifteen new advanced video lessons, providing a total of eleven hours of video training and 45 total lessons to teach you the basics and beyond. This self-paced tutorial explains Excel VBA from the ground up, demonstrating with each advancing lesson how you can increase your productivity. Clear, concise, step-by-step instructions are combined wit

  2. Teaching physics using Microsoft Excel

    Science.gov (United States)

    Uddin, Zaheer; Ahsanuddin, Muhammad; Khan, Danish Ahmed

    2017-09-01

    Excel is both ubiquitous and easily understandable. Most people from every walk of life know how to use MS office and Excel spreadsheets. Students are also familiar with spreadsheets. Most students know how to use spreadsheets for data analysis. Besides basic use of Excel, some important aspects of spreadsheets are highlighted in this article. MS Excel can be used to visualize effects of various parameters in a physical system. It can be used as a simulating tool; simulation of wind data has been done through spreadsheets in this study. Examples of Lissajous figures and a damped harmonic oscillator are presented in this article.

  3. Excel data analysis for dummies

    CERN Document Server

    Nelson, Stephen L

    2014-01-01

    Harness the power of Excel to discover what your numbers are hiding Excel Data Analysis For Dummies, 2nd Edition is the ultimate guide to getting the most out of your data. Veteran Dummies author Stephen L. Nelson guides you through the basic and not-so-basic features of Excel to help you discover the gems hidden in your rough data. From input, to analysis, to visualization, the book walks you through the steps that lead to superior data analysis. Excel is the number-one spreadsheet application, with ever-expanding capabilities. If you're only using it to balance the books, you're missing out

  4. His Excellency Mr Farukh Amil

    CERN Multimedia

    hugho, Chemli

    2017-01-01

    His Excellency Mr Farukh Amil Ambassador Extraordinary and Plenipotentiary Permanent Representative of the Islamic Republic of Pakistan to the United Nations Office and other international organisations in Geneva

  5. Learn Excel 2011 for Mac

    CERN Document Server

    Hart-Davis, Guy

    2011-01-01

    Microsoft Excel 2011 for Mac OS X is a powerful application, but many of its most impressive features can be difficult to find. Learn Excel 2011 for Mac by Guy Hart-Davis is a practical, hands-on approach to learning all of the details of Excel 2011 in order to get work done efficiently on Mac OS X. From using formulas and functions to creating databases, from analyzing data to automating tasks, you'll learn everything you need to know to put this powerful application to use for a variety of tasks. What you'll learn * The secrets of the Excel for Mac interface! * How to create effective workbo

  6. Challenges to Business Excellence: Some Empirical Evidence

    Directory of Open Access Journals (Sweden)

    Brown Alan

    2014-11-01

    Full Text Available The business excellence models are used by many organisations around the world as a strategic driver for business improvement and in some cases as the basis for applications for awards based on the models. These include the Baldrige, EFQM, Australian Business Excellence Framework and many other national and regional models. Whilst many award recipients showcase their achievements, comparatively little is known about the challenges and impediments they face in reaching and sustaining high levels of success as evidenced by winning awards. This paper seeks to identify challenges faced by examining the experience of a sample of Australian Business Excellence Award winners. Findings suggest that the primary challenges include; leadership support, drive and consistency throughout the organisation and communicating strategy and making it meaningful for people at all levels. The study also found variability in challenges across organisations.

  7. Attributes for Measuring Equity and Excellence in District Operation.

    Science.gov (United States)

    DeMoulin, Donald F.; Guyton, John W.

    In the quest for excellence, school districts have a variety of indicators or attributes available by which to gauge their progress. This model, used By the Equity and Excellence Research school districts in Mississippi, monitors achievement in relation to educational excellence. Team members established a list of attributes and various means of…

  8. Departmental Excellence: Constituencies in Tension.

    Science.gov (United States)

    Arnett, Ronald C.; Fritz, Janie M. Harden

    1999-01-01

    Places the question of departmental excellence within "the winds of historicity and temporality" and the political demands of multiple constituencies. Concludes that the task for every department that wants to pursue excellence is to know, understand, and operate within the hidden curriculum of a campus that socializes faculty to the…

  9. 101 ready-to-use Excel formulas

    CERN Document Server

    Alexander, Michael

    2014-01-01

    Mr. Spreadsheet has done it again with 101 easy-to-apply Excel formulas 101 Ready-to-Use Excel Formulas is filled with the most commonly-used, real-world Excel formulas that can be repurposed and put into action, saving you time and increasing your productivity. Each segment of this book outlines a common business or analysis problem that needs to be solved and provides the actual Excel formulas to solve the problem-along with detailed explanation of how the formulas work. Written in a user-friendly style that relies on a tips and tricks approach, the book details how to perform everyday Excel tasks with confidence. 101 Ready-to-Use Excel Formulas is sure to become your well-thumbed reference to solve your workplace problems. The recipes in the book are structured to first present the problem, then provide the formula solution, and finally show how it works so that it can be customized to fit your needs. The companion website to the book allows readers to easily test the formulas and provides visual confirmat...

  10. Skeletal Muscle Differentiation on a Chip Shows Human Donor Mesoangioblasts' Efficiency in Restoring Dystrophin in a Duchenne Muscular Dystrophy Model.

    Science.gov (United States)

    Serena, Elena; Zatti, Susi; Zoso, Alice; Lo Verso, Francesca; Tedesco, F Saverio; Cossu, Giulio; Elvassore, Nicola

    2016-12-01

    : Restoration of the protein dystrophin on muscle membrane is the goal of many research lines aimed at curing Duchenne muscular dystrophy (DMD). Results of ongoing preclinical and clinical trials suggest that partial restoration of dystrophin might be sufficient to significantly reduce muscle damage. Different myogenic progenitors are candidates for cell therapy of muscular dystrophies, but only satellite cells and pericytes have already entered clinical experimentation. This study aimed to provide in vitro quantitative evidence of the ability of mesoangioblasts to restore dystrophin, in terms of protein accumulation and distribution, within myotubes derived from DMD patients, using a microengineered model. We designed an ad hoc experimental strategy to miniaturize on a chip the standard process of muscle regeneration independent of variables such as inflammation and fibrosis. It is based on the coculture, at different ratios, of human dystrophin-positive myogenic progenitors and dystrophin-negative myoblasts in a substrate with muscle-like physiological stiffness and cell micropatterns. Results showed that both healthy myoblasts and mesoangioblasts restored dystrophin expression in DMD myotubes. However, mesoangioblasts showed unexpected efficiency with respect to myoblasts in dystrophin production in terms of the amount of protein produced (40% vs. 15%) and length of the dystrophin membrane domain (210-240 µm vs. 40-70 µm). These results show that our microscaled in vitro model of human DMD skeletal muscle validated previous in vivo preclinical work and may be used to predict efficacy of new methods aimed at enhancing dystrophin accumulation and distribution before they are tested in vivo, reducing time, costs, and variability of clinical experimentation. This study aimed to provide in vitro quantitative evidence of the ability of human mesoangioblasts to restore dystrophin, in terms of protein accumulation and distribution, within myotubes derived from

  11. The Strategic Study of National Quality Award through Business Excellence Model - The IBM, Panasonic and E.SUN Bank Cases in Taiwan

    Directory of Open Access Journals (Sweden)

    Shih-Lung Fu

    2009-10-01

    Full Text Available Quality is a dignity to a country and also masterpiece and bedrock for the development of a country. To recover economical prosperity immediately right from the II world war, Japan founded Demin Quality Award to encourage the improvement of quality and promote the whole scale of competence core for enterprises in 1951. All the products produced by Japan are entirely favoured by the customers around the world during the period of 1975. The Japanese made automobiles, electronics and appliances are inexpensive and competitive enough to sluggish the economy growth of USA. To counter the serious threats and regain the advantage of the market, the United States finally founded Malcolm Baldrige National Quality Award, MBNQA to provide a series of standards for excellence performance in 1987. European Excellence Award was set up by the European Foundation for Quality Management, EFQM for advancing the superiority of tech development in 1991. Among the developing countries, there is no exception can be made for the emerging countries, especially in area of Aisa. Taiwan is the first country in Asia to establish Taiwan National Quality Award, TNQA in 1990 to represent the great honour of quality, also the first national quality award in this area. As the candidate with the great potential to be developed country in this region, not only Taiwan is struggling to advance its technology, but also promote the quality issues by quality related policies of government. Therefore, this paper is to examine the process of involvement in the promotion to Taiwan National Quality Award for three different enterprises, the 1assessment of various dimension in company through spot visit by judges of TNQA, and the analysis of interview record from the superior executives for the further research and introductive contribution of this award. Conclusively, this paper is trying to draw the overview of how to improve the excellence of quality in the practice of business

  12. Connecting with The Biggest Loser: an extended model of parasocial interaction and identification in health-related reality TV shows.

    Science.gov (United States)

    Tian, Yan; Yoo, Jina H

    2015-01-01

    This study investigates audience responses to health-related reality TV shows in the setting of The Biggest Loser. It conceptualizes a model for audience members' parasocial interaction and identification with cast members and explores antecedents and outcomes of parasocial interaction and identification. Data analysis suggests the following direct relationships: (1) audience members' exposure to the show is positively associated with parasocial interaction, which in turn is positively associated with identification, (2) parasocial interaction is positively associated with exercise self-efficacy, whereas identification is negatively associated with exercise self-efficacy, and (3) exercise self-efficacy is positively associated with exercise behavior. Indirect effects of parasocial interaction and identification on exercise self-efficacy and exercise behavior are also significant. We discuss the theoretical and practical implications of these findings.

  13. Teach yourself visually complete Excel

    CERN Document Server

    McFedries, Paul

    2013-01-01

    Get the basics of Excel and then go beyond with this new instructional visual guide While many users need Excel just to create simple worksheets, many businesses and professionals rely on the advanced features of Excel to handle things like database creation and data analysis. Whatever project you have in mind, this visual guide takes you step by step through what each step should look like. Veteran author Paul McFedries first presents the basics and then gradually takes it further with his coverage of designing worksheets, collaborating between worksheets, working with visual data

  14. A novel, selective inhibitor of fibroblast growth factor receptors that shows a potent broad spectrum of antitumor activity in several tumor xenograft models.

    Science.gov (United States)

    Zhao, Genshi; Li, Wei-Ying; Chen, Daohong; Henry, James R; Li, Hong-Yu; Chen, Zhaogen; Zia-Ebrahimi, Mohammad; Bloem, Laura; Zhai, Yan; Huss, Karen; Peng, Sheng-Bin; McCann, Denis J

    2011-11-01

    The fibroblast growth factor receptors (FGFR) are tyrosine kinases that are present in many types of endothelial and tumor cells and play an important role in tumor cell growth, survival, and migration as well as in maintaining tumor angiogenesis. Overexpression of FGFRs or aberrant regulation of their activities has been implicated in many forms of human malignancies. Therefore, targeting FGFRs represents an attractive strategy for development of cancer treatment options by simultaneously inhibiting tumor cell growth, survival, and migration as well as tumor angiogenesis. Here, we describe a potent, selective, small-molecule FGFR inhibitor, (R)-(E)-2-(4-(2-(5-(1-(3,5-Dichloropyridin-4-yl)ethoxy)-1H-indazol-3yl)vinyl)-1H-pyrazol-1-yl)ethanol, designated as LY2874455. This molecule is active against all 4 FGFRs, with a similar potency in biochemical assays. It exhibits a potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in several tumor xenograft models representing the major FGF/FGFR relevant tumor histologies including lung, gastric, and bladder cancers and multiple myeloma, and with a well-defined pharmacokinetic/pharmacodynamic relationship. LY2874455 also exhibits a 6- to 9-fold in vitro and in vivo selectivity on inhibition of FGF- over VEGF-mediated target signaling in mice. Furthermore, LY2874455 did not show VEGF receptor 2-mediated toxicities such as hypertension at efficacious doses. Currently, this molecule is being evaluated for its potential use in the clinic.

  15. Restless led syndrome model Drosophila melanogaster show successful olfactory learning and 1-day retention of the acquired memory

    Directory of Open Access Journals (Sweden)

    Mika F. Asaba

    2013-09-01

    Full Text Available Restless Legs Syndrome (RLS is a prevalent but poorly understood disorder that ischaracterized by uncontrollable movements during sleep, resulting in sleep disturbance.Olfactory memory in Drosophila melanogaster has proven to be a useful tool for the study ofcognitive deficits caused by sleep disturbances, such as those seen in RLS. A recently generatedDrosophila model of RLS exhibited disturbed sleep patterns similar to those seen in humans withRLS. This research seeks to improve understanding of the relationship between cognitivefunctioning and sleep disturbances in a new model for RLS. Here, we tested learning andmemory in wild type and dBTBD9 mutant flies by Pavlovian olfactory conditioning, duringwhich a shock was paired with one of two odors. Flies were then placed in a T-maze with oneodor on either side, and successful associative learning was recorded when the flies chose theside with the unpaired odor. We hypothesized that due to disrupted sleep patterns, dBTBD9mutant flies would be unable to learn the shock-odor association. However, the current studyreports that the recently generated Drosophila model of RLS shows successful olfactorylearning, despite disturbed sleep patterns, with learning performance levels matching or betterthan wild type flies.

  16. Textbooks for Responsible Data Analysis in Excel

    Science.gov (United States)

    Garrett, Nathan

    2015-01-01

    With 27 million users, Excel (Microsoft Corporation, Seattle, WA) is the most common business data analysis software. However, audits show that almost all complex spreadsheets have errors. The author examined textbooks to understand why responsible data analysis is taught. A purposeful sample of 10 textbooks was coded, and then compared against…

  17. Textbooks for Responsible Data Analysis in Excel

    Science.gov (United States)

    Garrett, Nathan

    2015-01-01

    With 27 million users, Excel (Microsoft Corporation, Seattle, WA) is the most common business data analysis software. However, audits show that almost all complex spreadsheets have errors. The author examined textbooks to understand why responsible data analysis is taught. A purposeful sample of 10 textbooks was coded, and then compared against…

  18. Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons.

    Directory of Open Access Journals (Sweden)

    Patrick Aldrin-Kirk

    Full Text Available Synucleinopathies, characterized by intracellular aggregation of α-synuclein protein, share a number of features in pathology and disease progression. However, the vulnerable cell population differs significantly between the disorders, despite being caused by the same protein. While the vulnerability of dopamine cells in the substantia nigra to α-synuclein over-expression, and its link to Parkinson's disease, is well studied, animal models recapitulating the cortical degeneration in dementia with Lewy-bodies (DLB are much less mature. The aim of this study was to develop a first rat model of widespread progressive synucleinopathy throughout the forebrain using adeno-associated viral (AAV vector mediated gene delivery. Through bilateral injection of an AAV6 vector expressing human wild-type α-synuclein into the forebrain of neonatal rats, we were able to achieve widespread, robust α-synuclein expression with preferential expression in the frontal cortex. These animals displayed a progressive emergence of hyper-locomotion and dysregulated response to the dopaminergic agonist apomorphine. The animals receiving the α-synuclein vector displayed significant α-synuclein pathology including intra-cellular inclusion bodies, axonal pathology and elevated levels of phosphorylated α-synuclein, accompanied by significant loss of cortical neurons and a progressive reduction in both cortical and striatal ChAT positive interneurons. Furthermore, we found evidence of α-synuclein sequestered by IBA-1 positive microglia, which was coupled with a distinct change in morphology. In areas of most prominent pathology, the total α-synuclein levels were increased to, on average, two-fold, which is similar to the levels observed in patients with SNCA gene triplication, associated with cortical Lewy body pathology. This study provides a novel rat model of progressive cortical synucleinopathy, showing for the first time that cholinergic interneurons are vulnerable

  19. Excel formulas and functions for dummies

    CERN Document Server

    Bluttman, Ken

    2013-01-01

    Learn to use Excel for practical, day-to-day calculations Excel is a powerful program with more than 300 built-in functions that can be used to perform an almost infinite number of calculations. This friendly book shows you how to use the 150 most valuable ones in real-world situations: to compare the cost of buying vs. leasing a car, calculate classroom grades, or evaluate investment performance, for example. Another 85 specialized functions are also described. Detailed, step-by-step instructions help you understand how functions work within formulas and how you can use them t

  20. In vitro and in vivo models of cerebral ischemia show discrepancy in therapeutic effects of M2 macrophages.

    Directory of Open Access Journals (Sweden)

    Virginie Desestret

    Full Text Available THE INFLAMMATORY RESPONSE FOLLOWING ISCHEMIC STROKE IS DOMINATED BY INNATE IMMUNE CELLS: resident microglia and blood-derived macrophages. The ambivalent role of these cells in stroke outcome might be explained in part by the acquisition of distinct functional phenotypes: classically (M1 and alternatively activated (M2 macrophages. To shed light on the crosstalk between hypoxic neurons and macrophages, an in vitro model was set up in which bone marrow-derived macrophages were co-cultured with hippocampal slices subjected to oxygen and glucose deprivation. The results showed that macrophages provided potent protection against neuron cell loss through a paracrine mechanism, and that they expressed M2-type alternative polarization. These findings raised the possibility of using bone marrow-derived M2 macrophages in cellular therapy for stroke. Therefore, 2 million M2 macrophages (or vehicle were intravenously administered during the subacute stage of ischemia (D4 in a model of transient middle cerebral artery occlusion. Functional neuroscores and magnetic resonance imaging endpoints (infarct volumes, blood-brain barrier integrity, phagocytic activity assessed by iron oxide uptake were longitudinally monitored for 2 weeks. This cell-based treatment did not significantly improve any outcome measure compared with vehicle, suggesting that this strategy is not relevant to stroke therapy.

  1. C22-bronchial and T7-alveolar epithelial cell lines of the immortomouse are excellent murine cell culture model systems to study pulmonary peroxisome biology and metabolism.

    Science.gov (United States)

    Karnati, Srikanth; Palaniswamy, Saranya; Alam, Mohammad Rashedul; Oruqaj, Gani; Stamme, Cordula; Baumgart-Vogt, Eveline

    2016-03-01

    In pulmonary research, temperature-sensitive immortalized cell lines derived from the lung of the "immortomouse" (H-2k(b)-tsA58 transgenic mouse), such as C22 club cells and T7 alveolar epithelial cells type II (AECII), are frequently used cell culture models to study CC10 metabolism and surfactant synthesis. Even though peroxisomes are highly abundant in club cells and AECII and might fulfill important metabolic functions therein, these organelles have never been investigated in C22 and T7 cells. Therefore, we have characterized the peroxisomal compartment and its associated gene transcription in these cell lines. Our results show that peroxisomes are highly abundant in C22 and T7 cells, harboring a common set of enzymes, however, exhibiting specific differences in protein composition and gene expression patterns, similar to the ones observed in club cells and AECII in situ in the lung. C22 cells contain a lower number of larger peroxisomes, whereas T7 cells possess more numerous tubular peroxisomes, reflected also by higher levels of PEX11 proteins. Moreover, C22 cells harbor relatively higher amounts of catalase and antioxidative enzymes in distinct subcellular compartments, whereas T7 cells exhibit higher levels of ABCD3 and plasmalogen synthesizing enzymes as well as nuclear receptors of the PPAR family. This study suggest that the C22 and T7 cell lines of the immortomouse lung are useful models to study the regulation and metabolic function of the peroxisomal compartment and its alterations by paracrine factors in club cells and AECII.

  2. New nonlinear multivariable model shows the relationship between central corneal thickness and HRTII topographic parameters in glaucoma patients

    Directory of Open Access Journals (Sweden)

    Dimitrios Kourkoutas

    2009-04-01

    Full Text Available Dimitrios Kourkoutas1,2, Gerasimos Georgopoulos1, Antonios Maragos1, et al1Department of Ophthalmology, Medical School, Athens University, Athens, Greece; 2Department of Ophthalmology, 417 Hellenic Army Shared Fund Hospital, Athens, GreecePurpose: In this paper a new nonlinear multivariable regression method is presented in order to investigate the relationship between the central corneal thickness (CCT and the Heidelberg Retina Tomograph (HRTII optic nerve head (ONH topographic measurements, in patients with established glaucoma.Methods: Forty nine eyes of 49 patients with glaucoma were included in this study. Inclusion criteria were patients with (a HRT II ONH imaging of good quality (SD 30 < μm, (b reliable Humphrey visual field tests (30-2 program, and (c bilateral CCT measurements with ultrasonic contact pachymetry. Patients were classified as glaucomatous based on visual field and/or ONH damage. The relationship between CCT and topographic parameters was analyzed by using the new nonlinear multivariable regression model.Results: In the entire group, CCT was 549.78 ± 33.08 μm (range: 484–636 μm; intraocular pressure (IOP was 16.4 ± 2.67 mmHg (range: 11–23 mmHg; MD was −3.80 ± 4.97 dB (range: 4.04 – [−20.4] dB; refraction was −0.78 ± 2.46 D (range: −6.0 D to +3.0 D. The new nonlinear multivariable regression model we used indicated that CCT was significantly related (R2 = 0.227, p < 0.01 with rim volume nasally and type of diagnosis.Conclusions: By using the new nonlinear multivariable regression model, in patients with established glaucoma, our data showed that there is a statistically significant correlation between CCT and HRTII ONH structural measurements, in glaucoma patients.Keywords: central corneal thickness, glaucoma, optic nerve head, HRT 

  3. Phases and Actions of the Evolution of the Concept of Quality in Canada and Australia – A Theoretical Modelling of the Development of Knowledge in Business Performance in the XXI Century - The Approach to Excellence

    Directory of Open Access Journals (Sweden)

    Cristina Raluca Popescu

    2015-05-01

    Full Text Available In the paper “Phases and Actions of the Evolution of the Concept of Quality in Canada and Australia – A Theoretical Modelling of the Development of Knowledge in Business Performance in the XXI Century - The Approach to Excellence” the authors present the basic features of the phases and actions of the evolution of the concept of quality in Canada and Australia, as a theoretical modelling of the development of knowledge in business performance in the XXI century in order to improve the organizational processes so that excellence can be achieved.

  4. Excel for Scientists and Engineers

    CERN Document Server

    Verschuuren, Dr Gerard

    2005-01-01

    For scientists and engineers tired of trying to learn Excel with examples from accounting, this self-paced tutorial is loaded with informative samples from the world of science and engineering. Techniques covered include creating a multifactorial or polynomial trendline, generating random samples with various characteristics, and tips on when to use PEARSON instead of CORREL. Other science- and engineering-related Excel features such as making columns touch each other for a histogram, unlinking a chart from its data, and pivoting tables to create frequency distributions are also covered.

  5. Defining excellence in vascular neurosurgery.

    Science.gov (United States)

    Sanai, Nader; Spetzler, Robert F

    2010-01-01

    Success as a vascular neurosurgeon almost always begins with passion, an inherent love for the work that drives an insatiable desire for personal improvement. A personal definition of excellence in vascular neurosurgery includes several fundamental qualities: mastery of the basics, refinement of technique, advancement of technology, investigative study, advanced decision making, microsurgical innovation, a well-rounded surgical armamentarium, and a lifelong commitment to teaching. Ultimately, the reward for these efforts is the ability to influence generations to come, particularly as one follows the rising careers of former trainees, each redefining the term "excellence" in vascular neurosurgery.

  6. Automating Partial Period Bond Valuation with Excel's Day Counting Functions

    Science.gov (United States)

    Vicknair, David; Spruell, James

    2009-01-01

    An Excel model for calculating the actual price of bonds under a 30 day/month, 360 day/year day counting assumption by nesting the DAYS360 function within the PV function is developed. When programmed into an Excel spreadsheet, the model can accommodate annual and semiannual payment bonds sold on or between interest dates using six fundamental…

  7. Patient satisfaction: focusing on "excellent".

    Science.gov (United States)

    Otani, Koichiro; Waterman, Brian; Faulkner, Kelly M; Boslaugh, Sarah; Burroughs, Thomas E; Dunagan, W Claiborne

    2009-01-01

    In an emerging competitive market such as healthcare, managers should focus on achieving excellent ratings to distinguish their organization from others. When it comes to customer loyalty, "excellent" has a different meaning. Customers who are merely satisfied often do not come back. The purpose of this study was to find out what influences adult patients to rate their overall experience as "excellent." The study used patient satisfaction data collected from one major academic hospital and four community hospitals. After conducting a multiple logistic regression analysis, certain attributes were shown to be more likely than others to influence patients to rate their experiences as excellent. The study revealed that staff care is the most influential attribute, followed by nursing care. These two attributes are distinctively stronger drivers of overall satisfaction than are the other attributes studied (i.e., physician care, admission process, room, and food). Staff care and nursing care are under the control of healthcare managers. If improvements are needed, they can be accomplished through training programs such as total quality management or continuous quality improvement, through which staff employees and nurses learn to be sensitive to patients' needs. Satisfying patients' needs is the first step toward having loyal patients, so hospitals that strive to ensure their patients are completely satisfied are more likely to prosper.

  8. Using Excel in the Classroom.

    Science.gov (United States)

    Summerville, Jennifer; Morrow, Jean; Howell, Dusti

    Microsoft Excel is a sophisticated and flexible reporting, planning, and presentation tool that teachers can use effectively for curriculum prep, class projects, budget planning and reporting, and even as a database. This book, a how-to guide for teachers at all grade levels, provides information on the fundamentals of creating powerful…

  9. Leadership, excellence, creativity and innovation

    OpenAIRE

    Coulson-Thomas, Colin

    2016-01-01

    Raises questions about the meaning, purpose and practice of contemporary leadership in relation to excellence, creativity and innovation, covering leadership qualities, the context and requirements of leadership, leadership at different stages of development, creativity and innovation, CEOs and top down leadership, entrepreneurship and shared leadership, leading the network organisation, shared and collective leadership, the role and contribution of boards, key questions for boards, leadershi...

  10. Leadership, excellence, creativity and innovation

    OpenAIRE

    Coulson-Thomas, Colin

    2016-01-01

    Raises questions about the meaning, purpose and practice of contemporary leadership in relation to excellence, creativity and innovation, covering leadership qualities, the context and requirements of leadership, leadership at different stages of development, creativity and innovation, CEOs and top down leadership, entrepreneurship and shared leadership, leading the network organisation, shared and collective leadership, the role and contribution of boards, key questions for boards, leadershi...

  11. Langerhans cell histiocytosis of atlantoaxial joint in a middle-aged man presenting with deafness as first symptom and soft-tissue mass at neck showing excellent response to radiotherapy alone: Report of an extremely rare and unusual clinical condition and review of literature

    Science.gov (United States)

    Mondal, Dodul; Julka, P. K.; Jana, Manisha; Walia, Ritika; Chaudhuri, Tamojit

    2014-01-01

    Langerhans cell histiocytosis (LCH) is a disorder of clonal proliferation of dendritic cell mainly occurring in children. Spine involvement is rare. This usually presents with pain and torticollis when neck is involved. Histopathology with immunohistochemistry is confirmatory. Local curative therapy with excision or curettage is used for localized disease. Radiotherapy is usually reserved for selected cases. Systemic chemotherapy is the treatment of choice for widespread systemic disease. In this article, we present an unusual presentation of atlantoaxial LCH with mastoid involvement resulting in hearing loss as the first symptom and quadruparesis in a middle aged male patient, which was also associated with soft-tissue mass at the nape of the neck and deafness. The patient was treated with radical radiotherapy, which provided excellent response to the disease. Involvement of atlantoaxial joint and temporal bone associated with soft-tissue mass neck and deafness in a middle-aged man is an extremely rare clinical situation. PMID:25506166

  12. Surface Spectroscopy Center Of Excellence Project

    Science.gov (United States)

    Wooden, Diane

    2014-01-01

    We propose to develop a national center of excellence in Regolith Radiative Transfer (RRT), i.e., in modeling spectral reflectivity and emissivity of grainy or structured surfaces. The focus is the regime where the structural elements of grainy surfaces have grain sizes and separations of tens of microns, comparable to the wavelengths carrying diagnostic compositional information. This regime is of fundamental interest to remote sensing of planetary and terrestrial surfaces.

  13. Basic statistics with Microsoft Excel: a review.

    Science.gov (United States)

    Divisi, Duilio; Di Leonardo, Gabriella; Zaccagna, Gino; Crisci, Roberto

    2017-06-01

    The scientific world is enriched daily with new knowledge, due to new technologies and continuous discoveries. The mathematical functions explain the statistical concepts particularly those of mean, median and mode along with those of frequency and frequency distribution associated to histograms and graphical representations, determining elaborative processes on the basis of the spreadsheet operations. The aim of the study is to highlight the mathematical basis of statistical models that regulate the operation of spreadsheets in Microsoft Excel.

  14. The Relationship Between Job Satisfaction And Organizational Excellence In Sport Organizations

    Directory of Open Access Journals (Sweden)

    Rasoul Faraji

    2012-06-01

    Full Text Available The main purpose of the study was to determine the relationship between job satisfaction and organizational excellence in physical education (P.E. general offices of Iran's provinces. A survey that contains European Foundation for Quality Management (EFQM criteria and Oldham & Huckman's (1975 job satisfaction questionnaire are applied to P.E. general offices of Iran's provinces (ten provinces selected by classified random manner. Validity of the questionnaires verified by the experts and their reliability also calculated in a pilot study (α=0.928 and α=0.83 respectively for EFQM and job satisfaction questionnaires. 550 questionnaires distributed among the staff however, 337 questionnaires were returned and included in statistical analyze. The results showed significant relationship between job satisfaction and all EFQM excellence model criteria (p<0.05. About job satisfaction, there was no significant difference in between the ten selected organizations. However, a significant difference observed between selected provinces’ organizational excellence (p<0.05. The relationship between job satisfaction and organizational excellence shows that organizations (specially sport organizations that are going to implementing organizational excellence model such as EFQM, should be aware of job satisfaction which has a supporting role for the successful implementation. Furthermore, it seems that similar employment rules were the reason for non-significant differences among the selected organizations' job satisfaction. On the other hand, it seems that numerous factors affecting EFQM criteria can induce significant differences in the organizational excellence scores of these organizations.

  15. Bioavailability of particulate metal to zebra mussels: Biodynamic modelling shows that assimilation efficiencies are site-specific

    Energy Technology Data Exchange (ETDEWEB)

    Bourgeault, Adeline, E-mail: bourgeault@ensil.unilim.fr [Cemagref, Unite de Recherche Hydrosystemes et Bioprocedes, 1 rue Pierre-Gilles de Gennes, 92761 Antony (France); FIRE, FR-3020, 4 place Jussieu, 75005 Paris (France); Gourlay-France, Catherine, E-mail: catherine.gourlay@cemagref.fr [Cemagref, Unite de Recherche Hydrosystemes et Bioprocedes, 1 rue Pierre-Gilles de Gennes, 92761 Antony (France); FIRE, FR-3020, 4 place Jussieu, 75005 Paris (France); Priadi, Cindy, E-mail: cindy.priadi@eng.ui.ac.id [LSCE/IPSL CEA-CNRS-UVSQ, Avenue de la Terrasse, 91198 Gif-sur-Yvette (France); Ayrault, Sophie, E-mail: Sophie.Ayrault@lsce.ipsl.fr [LSCE/IPSL CEA-CNRS-UVSQ, Avenue de la Terrasse, 91198 Gif-sur-Yvette (France); Tusseau-Vuillemin, Marie-Helene, E-mail: Marie-helene.tusseau@ifremer.fr [IFREMER Technopolis 40, 155 rue Jean-Jacques Rousseau, 92138 Issy-Les-Moulineaux (France)

    2011-12-15

    This study investigates the ability of the biodynamic model to predict the trophic bioaccumulation of cadmium (Cd), chromium (Cr), copper (Cu), nickel (Ni) and zinc (Zn) in a freshwater bivalve. Zebra mussels were transplanted to three sites along the Seine River (France) and collected monthly for 11 months. Measurements of the metal body burdens in mussels were compared with the predictions from the biodynamic model. The exchangeable fraction of metal particles did not account for the bioavailability of particulate metals, since it did not capture the differences between sites. The assimilation efficiency (AE) parameter is necessary to take into account biotic factors influencing particulate metal bioavailability. The biodynamic model, applied with AEs from the literature, overestimated the measured concentrations in zebra mussels, the extent of overestimation being site-specific. Therefore, an original methodology was proposed for in situ AE measurements for each site and metal. - Highlights: > Exchangeable fraction of metal particles did not account for the bioavailability of particulate metals. > Need for site-specific biodynamic parameters. > Field-determined AE provide a good fit between the biodynamic model predictions and bioaccumulation measurements. - The interpretation of metal bioaccumulation in transplanted zebra mussels with biodynamic modelling highlights the need for site-specific assimilation efficiencies of particulate metals.

  16. Experimental results showing the internal three-component velocity field and outlet temperature contours for a model gas turbine combustor

    CSIR Research Space (South Africa)

    Meyers, BC

    2011-09-01

    Full Text Available ,2]. These inconsistencies are especially great when combustion is simulated when there are already flow inconsistencies after modeling the flow in cold flow simulations. To enable the improvement of CFD modeling and techniques, a CFD test case has been created to aid.... [7], attempts have to be made to ensure that as many of the factors that influence the combustor flow should be included in the tests. The combustor in which these experiments were performed is a full, non-premixed, cylindrical, can-type combustor...

  17. Samuel P. Massie Chair of Excellence Program

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, James H

    2014-12-15

    Abstract In 1994 the Department of Energy established the DOE Chair of Excellence Professorship in Environmental Disciplines Program. In 2004, the Massie Chair of Excellence Professor at Howard University transitioned from Dr. Edward Martin to Dr. James H. Johnson, Jr. At the time of his appointment Dr. Johnson served as professor of civil engineering and Dean of the College of Engineering, Architecture and Computer Sciences. Program activities under Dr. Johnson were in the following areas: • Increase the institution’s capacity to conduct scientific research and technical investigations at the cutting-edge. • Promote interactions, collaborations and partnerships between the private sector, Federal agencies, majority research institutes and other HBCUs. • Assist other HBCUs in reaching parity in engineering and related fields. • Mentor young investigators and be a role model for students.

  18. Samuel P. Massie Chair of Excellence Program

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, James H. [Howard Univ., Washington, DC (United States)

    2014-12-01

    Abstract In 1994 the Department of Energy established the DOE Chair of Excellence Professorship in Environmental Disciplines Program. In 2004, the Massie Chair of Excellence Professor at Howard University transitioned from Dr. Edward Martin to Dr. James H. Johnson, Jr. At the time of his appointment Dr. Johnson served as professor of civil engineering and Dean of the College of Engineering, Architecture and Computer Sciences. Program activities under Dr. Johnson were in the following areas: • Increase the institution’s capacity to conduct scientific research and technical investigations at the cutting-edge. • Promote interactions, collaborations and partnerships between the private sector, Federal agencies, majority research institutes and other HBCUs. • Assist other HBCUs in reaching parity in engineering and related fields. • Mentor young investigators and be a role model for students.

  19. Business Excellence in Kazakh Higher Education Institutions

    Directory of Open Access Journals (Sweden)

    Hatice Camgoz Akdag

    2011-07-01

    Full Text Available The aim of this paper is to deepen and to encourage further research for sustaining quality improvement in Kazakh Higher Education Institutions. This paper is explaining the Kazakh education system and is also trying to figure out whether if it fits to the European Foundation for Quality Management (EFQM excellence model. The paper is based on literature concerning the Kazakh Higher Education system.  The pros and cons are also mentioned in the paper. In accordance to this it is easier to find the strengths and weaknesses of the system and finally a list of factors are given in order to be a guide of excellence for the Kazakh Higher Education Institutes.

  20. Understanding Statistical Mechanics and Biophysics Using Excel

    Science.gov (United States)

    Nelson, Peter

    2009-03-01

    A new approach to teaching statistical mechanics and biophysics is presented using the classic two-box system from statistical mechanics as an example. This approach makes advanced physics concepts accessible to a broad audience including undergraduates with no calculus background. Students develop a simple Excel spreadsheet that implements a kinetic Monte Carlo (kMC) simulation algorithm ``from scratch''. The students discover for themselves the properties of the system by analyzing the simulation output in a directed, activity-based exercise. By changing the number and initial distribution of the particles, students see how the system approaches equilibrium and how system variability changes with system size. A finite difference solution is also implemented in Excel, and students compare its predictions with the kMC results. This approach is quite different from using ``canned'' computer demonstrations, as students design, implement and debug the simulation themselves -- ensuring that they understand the model system intimately.

  1. An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model

    DEFF Research Database (Denmark)

    Kempf, Stefan J; Metaxas, Athanasios; Ibáñez-Vea, María

    2016-01-01

    The aim of this study was to elucidate the molecular signature of Alzheimer's disease-associated amyloid pathology.We used the double APPswe/PS1ΔE9 mouse, a widely used model of cerebral amyloidosis, to compare changes in proteome, including global phosphorylation and sialylated N-linked glycosyl...

  2. An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer´s mouse model

    DEFF Research Database (Denmark)

    Kempf, Stefan; Metaxas, Athanasios; Vea, Maria Ibanez

    2016-01-01

    The aim of this study was to elucidate the molecular signature of Alzheimer ́s disease-associated amyloid pathology. We used the double APPswe/PS1ΔE9 mouse, a widely used model of cerebral amyloidosis, to compare changes in proteome, including global phosphorylation and sialylated N-linked glycos...

  3. A test of the intergenerational conflict model in Indonesia shows no evidence of earlier menopause in female-dispersing groups.

    Science.gov (United States)

    Snopkowski, Kristin; Moya, Cristina; Sear, Rebecca

    2014-08-07

    Menopause remains an evolutionary puzzle, as humans are unique among primates in having a long post-fertile lifespan. One model proposes that intergenerational conflict in patrilocal populations favours female reproductive cessation. This model predicts that women should experience menopause earlier in groups with an evolutionary history of patrilocality compared with matrilocal groups. Using data from the Indonesia Family Life Survey, we test this model at multiple timescales: deep historical time, comparing age at menopause in ancestrally patrilocal Chinese Indonesians with ancestrally matrilocal Austronesian Indonesians; more recent historical time, comparing age at menopause in ethnic groups with differing postmarital residence within Indonesia and finally, analysing age at menopause at an individual-level, assuming a woman facultatively adjusts her age at menopause based on her postmarital residence. We find a significant effect only at the intermediate timescale where, contrary to predictions, ethnic groups with a history of multilocal postnuptial residence (where couples choose where to live) have the slowest progression to menopause, whereas matrilocal and patrilocal ethnic groups have similar progression rates. Multilocal residence may reduce intergenerational conflicts between women, thus influencing reproductive behaviour, but our results provide no support for the female-dispersal model of intergenerational conflict as an explanation of menopause.

  4. Demonstrating Chirality: Using a Mirror with Physical Models To Show Non-superimposability of Chiral Molecules with Their Mirror Images.

    Science.gov (United States)

    Collins, Michael J.

    2001-01-01

    Presents a remarkable demonstration on chiralty in molecules and the existence of enantiomers, also known as non-superimposable mirror images. Uses a mirror, a physical model of a molecule, and a bit of trickery involving the non-superimposable mirror image. (Author/NB)

  5. Assessing the Rothstein Test: Does It Really Show Teacher Value-Added Models Are Biased? Working Paper 5

    Science.gov (United States)

    Goldhaber, Dan; Chaplin, Duncan

    2012-01-01

    In a provocative and influential paper, Jesse Rothstein (2010) finds that standard value-added models (VAMs) suggest implausible future teacher effects on past student achievement, a finding that obviously cannot be viewed as causal. This is the basis of a falsification test (the Rothstein falsification test) that appears to indicate bias in VAM…

  6. Assessing the "Rothstein Test": Does It Really Show Teacher Value-Added Models Are Biased? Working Paper 71

    Science.gov (United States)

    Goldhaber, Dan; Chaplin, Duncan

    2012-01-01

    In a provocative and influential paper, Jesse Rothstein (2010) finds that standard value-added models (VAMs) suggest implausible future teacher effects on past student achievement, a finding that obviously cannot be viewed as causal. This is the basis of a falsification test (the Rothstein falsification test) that appears to indicate bias in VAM…

  7. The Kallikrein Inhibitor from Bauhinia bauhinioides (BbKI) shows antithrombotic properties in venous and arterial thrombosis models.

    Science.gov (United States)

    Brito, Marlon V; de Oliveira, Cleide; Salu, Bruno R; Andrade, Sonia A; Malloy, Paula M D; Sato, Ana C; Vicente, Cristina P; Sampaio, Misako U; Maffei, Francisco H A; Oliva, Maria Luiza V

    2014-05-01

    The Bauhinia bauhinioides Kallikrein Inhibitor (BbKI) is a Kunitz-type serine peptidase inhibitor of plant origin that has been shown to impair the viability of some tumor cells and to feature a potent inhibitory activity against human and rat plasma kallikrein (Kiapp 2.4 nmol/L and 5.2 nmol/L, respectively). This inhibitory activity is possibly responsible for an effect on hemostasis by prolonging activated partial thromboplastin time (aPTT). Because the association between cancer and thrombosis is well established, we evaluated the possible antithrombotic activity of this protein in venous and arterial thrombosis models. Vein thrombosis was studied in the vena cava ligature model in Wistar rats, and arterial thrombosis in the photochemical induced endothelium lesion model in the carotid artery of C57 black 6 mice. BbKI at a concentration of 2.0 mg/kg reduced the venous thrombus weight by 65% in treated rats in comparison to rats in the control group. The inhibitor prolonged the time for total artery occlusion in the carotid artery model mice indicating that this potent plasma kallikrein inhibitor prevented thrombosis.

  8. A test of the intergenerational conflict model in Indonesia shows no evidence of earlier menopause in female-dispersing groups

    Science.gov (United States)

    Snopkowski, Kristin; Moya, Cristina; Sear, Rebecca

    2014-01-01

    Menopause remains an evolutionary puzzle, as humans are unique among primates in having a long post-fertile lifespan. One model proposes that intergenerational conflict in patrilocal populations favours female reproductive cessation. This model predicts that women should experience menopause earlier in groups with an evolutionary history of patrilocality compared with matrilocal groups. Using data from the Indonesia Family Life Survey, we test this model at multiple timescales: deep historical time, comparing age at menopause in ancestrally patrilocal Chinese Indonesians with ancestrally matrilocal Austronesian Indonesians; more recent historical time, comparing age at menopause in ethnic groups with differing postmarital residence within Indonesia and finally, analysing age at menopause at an individual-level, assuming a woman facultatively adjusts her age at menopause based on her postmarital residence. We find a significant effect only at the intermediate timescale where, contrary to predictions, ethnic groups with a history of multilocal postnuptial residence (where couples choose where to live) have the slowest progression to menopause, whereas matrilocal and patrilocal ethnic groups have similar progression rates. Multilocal residence may reduce intergenerational conflicts between women, thus influencing reproductive behaviour, but our results provide no support for the female-dispersal model of intergenerational conflict as an explanation of menopause. PMID:24966311

  9. Combining Mat lab with Excel to Work Out Liner Planning Model of Material Field Planning of Dike Project%Matlab 与 Excel 联合求解堤防工程土料场规划的线性规划模型

    Institute of Scientific and Technical Information of China (English)

    刘森; 刘琳

    2015-01-01

    堤防工程,尤其是沿线较长堤防的料场规划问题,一直是施工组织设计中的难点和重点.文章利用Mat lab和Excel联合求解堤防工程土料场规划的线性规划模型,由于Met lab这一数学软件将高性能的数值计算和可视化集成在一起,并提供了大量的内置函数,思路清晰,便于理解,运算结果一目了然,能很好的指导施工、节省投资.%The dike project,especially the planning problem about long material field along it,is always being the difficulty and key of construction organization design.Combining Mat lab with Excel to work out the liner planning model of the soil material field along the dike project,Met lab,the math software integrates high value calculation with visualization,clear to think,easy to study,the calculation results stick out a mile,is good in guiding the construction and saving the investment.

  10. Empowering boards to become instruments of innovation and excellence

    OpenAIRE

    Coulson-Thomas, Colin

    2016-01-01

    Examines the roles of directors, boards and CEOs in relation to excellence, innovation, innovative business models, leadership and human capital and the digital economy, aspects of leadership and the new, collective and shared leadership required for creativity, innovation and entrepreneurship. Written to encourage discussion at the 2016 Dubai Global Convention and 26th World Congress for Business Excellence & Innovation.

  11. A Mouse Model of Hyperproliferative Human Epithelium Validated by Keratin Profiling Shows an Aberrant Cytoskeletal Response to Injury

    Directory of Open Access Journals (Sweden)

    Samal Zhussupbekova

    2016-07-01

    Full Text Available A validated animal model would assist with research on the immunological consequences of the chronic expression of stress keratins KRT6, KRT16, and KRT17, as observed in human pre-malignant hyperproliferative epithelium. Here we examine keratin gene expression profile in skin from mice expressing the E7 oncoprotein of HPV16 (K14E7 demonstrating persistently hyperproliferative epithelium, in nontransgenic mouse skin, and in hyperproliferative actinic keratosis lesions from human skin. We demonstrate that K14E7 mouse skin overexpresses stress keratins in a similar manner to human actinic keratoses, that overexpression is a consequence of epithelial hyperproliferation induced by E7, and that overexpression further increases in response to injury. As stress keratins modify local immunity and epithelial cell function and differentiation, the K14E7 mouse model should permit study of how continued overexpression of stress keratins impacts on epithelial tumor development and on local innate and adaptive immunity.

  12. Personality characteristics of excellent lean managers

    DEFF Research Database (Denmark)

    Nielsen, Jacob Steendahl; Boer, Harry; Lindgren, Peter

    2016-01-01

    Today many Danish companies are implementing Lean and hereby trying to implement a continuous improvement (CI) program and culture. We have observed that companies can easily implement the artifacts of CI, such as Kaizen boards, Kaizen meetings, Performance management (KPI), A3 and PDCA reports......, and analytical tools. However, many companies struggle with developing a CI culture and DNA. Reasons for this can be many but the authors of this paper believe that one of the main reasons is the mindset and personality of the Lean managers. This paper addresses the question: Which personality traits should...... excellent Lean managers have? Based on an assessment done by a panel of Lean experts composed from 26 different Danish companies, this paper presents a profile description of an excellent Lean manager, which encompasses 16 different personality traits. A comparison with the average Dane shows some important...

  13. On the Duty of Excellence

    Directory of Open Access Journals (Sweden)

    Pierre-Jean Labarriere

    1998-12-01

    Full Text Available The Greek term apntí. art of moderation, strategy of happiness, is a fundamental attitude not addressed by the mere "moral" connotation of the terms merit and virtue. It defines, instead, a leve! of excellency reconciliating the interior and the exterior. theory and praxis, knowledge and action. Far from any hard stoicism, virtue is a force in movement; it translates if necessary the human capacity of "changing circumstances. "As a true road of sense displayed "with and for others" (Ricoeur, virtue assumes a poietic dimension expressed by a certain power of creation, where not only the individual but also the political are at stake.

  14. A network model shows the importance of coupled processes in the microbial N cycle in the Cape Fear River Estuary

    Science.gov (United States)

    Hines, David E.; Lisa, Jessica A.; Song, Bongkeun; Tobias, Craig R.; Borrett, Stuart R.

    2012-06-01

    Estuaries serve important ecological and economic functions including habitat provision and the removal of nutrients. Eutrophication can overwhelm the nutrient removal capacity of estuaries and poses a widely recognized threat to the health and function of these ecosystems. Denitrification and anaerobic ammonium oxidation (anammox) are microbial processes responsible for the removal of fixed nitrogen and diminish the effects of eutrophication. Both of these microbial removal processes can be influenced by direct inputs of dissolved inorganic nitrogen substrates or supported by microbial interactions with other nitrogen transforming pathways such as nitrification and dissimilatory nitrate reduction to ammonium (DNRA). The coupling of nitrogen removal pathways to other transformation pathways facilitates the removal of some forms of inorganic nitrogen; however, differentiating between direct and coupled nitrogen removal is difficult. Network modeling provides a tool to examine interactions among microbial nitrogen cycling processes and to determine the within-system history of nitrogen involved in denitrification and anammox. To examine the coupling of nitrogen cycling processes, we built a nitrogen budget mass balance network model in two adjacent 1 cm3 sections of bottom water and sediment in the oligohaline portion of the Cape Fear River Estuary, NC, USA. Pathway, flow, and environ ecological network analyses were conducted to characterize the organization of nitrogen flow in the estuary and to estimate the coupling of nitrification to denitrification and of nitrification and DNRA to anammox. Centrality analysis indicated NH4+ is the most important form of nitrogen involved in removal processes. The model analysis further suggested that direct denitrification and coupled nitrification-denitrification had similar contributions to nitrogen removal while direct anammox was dominant to coupled forms of anammox. Finally, results also indicated that partial

  15. 基于卓越工程师培养模式的产学研合作教育%On Cooperative Education of Industry, Learning and Re-search Based on Excellent Engineer Training Model

    Institute of Scientific and Technical Information of China (English)

    曾利军; 刘卉; 李泽军

    2013-01-01

    In order to improve the traditional closed cooperative education model of industry, learning and research, the coopera-tive education of industry, learning and research based on excel-lent engineer training model is proposed. The idea of this model is to give full play to the respective advantages of scientific re-search units, schools and enterprises, and enhance students' practical engineering ability through integrating the teaching re-sources and environment and the respective teaching and scien-tific research equipment of the three. This will also organically combine teachers' theoretical teaching and practical engineering ability with their scientific research ability. At the same time, it is also an education model of cultivating interdisciplinary talents with high quality, high skill and high employment ability, which takes account of the geographical locations and conditions of cer-tain schools.%为改善传统封闭的产学研合作教育模式,提出了一种基于卓越工程师培养模式的产学研合作教育。其思路是充分发挥科研单位、学校和企业各自优势,通过整合三者的教学资源和教学环境以及各自不同的教学科研设备以此来加强学生实际工程能力。将教师的理论教学和工程实践生产能力以及科研能力有机结合起来,同时考虑学校自身的地理位置和条件以培养高素质、高能力以及高就业能力的复合型人才。

  16. Technology Tips: Two Useful Functions for Excel Grade Books

    Science.gov (United States)

    Lobo, Glen E.

    2006-01-01

    The topic of this month's department is writing macros in Excel. The examples given are of use to teachers who maintain their grade books in Excel, and show, for example, how to drop the lowest or choose the highest scores from a student's record. The Surfing Note cites a collection of online tools and resources for professional development…

  17. Bamboo Leaf Flavones and Tea Polyphenols Show a Lipid-lowering Effect in a Rat Model of Hyperlipidemia.

    Science.gov (United States)

    Yang, C; Yifan, L; Dan, L; Qian, Y; Ming-yan, J

    2015-12-01

    At present, most of the lipid-lowering drugs are western medicines, which have a lot of adverse reactions. Zhucha, an age-old Uyghur medicine, is made up of bamboo leaves and tea (green tea), which has good efficacy and lipid-lowering effect. The purpose of this study was to undertake a pharmacodynamic examination of the optimal proportions of bamboo leaf flavones and tea polyphenols required to achieve lipid lowering in rats. A hyperlipidemia rat model was used to examine the lipid lowering effects of bamboo leaf flavones and tea polyphenols. Wistar rats were divided into 13 groups including one hyperlipidemia model group and 2 positive drug groups as well as experimental groups (9 groups dosed with different proportions of bamboo leaf flavones and tea polyphenols, the 3 dosages of bamboo leaf flavones were 75 mg/kg/d, 50 mg/kg/d and 25 mg/kg/d respectively, the 3 dosages of tea polyphenol were 750 mg/kg/d, 500 mg/kg/d and 250 mg/kg/d). The weight, the levels of triglyceride (TG) and high-density lipoprotein cholesterol (HDL) were determined. A high dose of bamboo leaf flavones (75 mg/kg/d) combined with a medium dose of tea polyphenols (500 mg/kg/d) was deemed to be optimal for achieving a lipid-lowering effect, the weight had the smallest increase and the level of TG and HDL was similar to positive control. The bamboo leaf flavones and tea polyphenols were mixed according to a certain proportion (1:6.7), and the mixture achieved a lipid-lowering effect and might prove to be useful as a natural lipid-lowering agent.

  18. Pridopidine, a dopamine stabilizer, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model.

    Science.gov (United States)

    Squitieri, Ferdinando; Di Pardo, Alba; Favellato, Mariagrazia; Amico, Enrico; Maglione, Vittorio; Frati, Luigi

    2015-11-01

    Huntington disease (HD) is a neurodegenerative disorder for which new treatments are urgently needed. Pridopidine is a new dopaminergic stabilizer, recently developed for the treatment of motor symptoms associated with HD. The therapeutic effect of pridopidine in patients with HD has been determined in two double-blind randomized clinical trials, however, whether pridopidine exerts neuroprotection remains to be addressed. The main goal of this study was to define the potential neuroprotective effect of pridopidine, in HD in vivo and in vitro models, thus providing evidence that might support a potential disease-modifying action of the drug and possibly clarifying other aspects of pridopidine mode-of-action. Our data corroborated the hypothesis of neuroprotective action of pridopidine in HD experimental models. Administration of pridopidine protected cells from apoptosis, and resulted in highly improved motor performance in R6/2 mice. The anti-apoptotic effect observed in the in vitro system highlighted neuroprotective properties of the drug, and advanced the idea of sigma-1-receptor as an additional molecular target implicated in the mechanism of action of pridopidine. Coherent with protective effects, pridopidine-mediated beneficial effects in R6/2 mice were associated with an increased expression of pro-survival and neurostimulatory molecules, such as brain derived neurotrophic factor and DARPP32, and with a reduction in the size of mHtt aggregates in striatal tissues. Taken together, these findings support the theory of pridopidine as molecule with disease-modifying properties in HD and advance the idea of a valuable therapeutic strategy for effectively treating the disease. © 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  19. Actinobacteria from Termite Mounds Show Antiviral Activity against Bovine Viral Diarrhea Virus, a Surrogate Model for Hepatitis C Virus

    Directory of Open Access Journals (Sweden)

    Marina Aiello Padilla

    2015-01-01

    Full Text Available Extracts from termite-associated bacteria were evaluated for in vitro antiviral activity against bovine viral diarrhea virus (BVDV. Two bacterial strains were identified as active, with percentages of inhibition (IP equal to 98%. Both strains were subjected to functional analysis via the addition of virus and extract at different time points in cell culture; the results showed that they were effective as posttreatments. Moreover, we performed MTT colorimetric assays to identify the CC50, IC50, and SI values of these strains, and strain CDPA27 was considered the most promising. In parallel, the isolates were identified as Streptomyces through 16S rRNA gene sequencing analysis. Specifically, CDPA27 was identified as S. chartreusis. The CDPA27 extract was fractionated on a C18-E SPE cartridge, and the fractions were reevaluated. A 100% methanol fraction was identified to contain the compound(s responsible for antiviral activity, which had an SI of 262.41. GC-MS analysis showed that this activity was likely associated with the compound(s that had a peak retention time of 5 min. Taken together, the results of the present study provide new information for antiviral research using natural sources, demonstrate the antiviral potential of Streptomyces chartreusis compounds isolated from termite mounds against BVDV, and lay the foundation for further studies on the treatment of HCV infection.

  20. Developing versus developed companies in Business Excellence initiatives

    DEFF Research Database (Denmark)

    Haffer, Rafal; Kristensen, Kai

    2008-01-01

    of correlations between EFQM model indicators and performance results. The data are next estimated as a structural equation model by partial least squares using SmartPLS software (Ringle et al., 2005). That estimation is conducted on the model of the Danish Business Excellence Index methodology (Kristensen et al...... results from the Business Excellence Model as a proxy for actual financial results in Poland. Data and results from a similar study done in Denmark are also described; thus, a comparison between developing Polish companies and developed Danish ones is included. Poland and Denmark are used as cases of......The paper reports the advance of Polish companies in Business Excellence initiatives. It indicates how these activities influence their performance. EFQM Excellence Model indicators are used as the evaluation criteria for the study. The performance variable is introduced to ensure the calculation...

  1. An inducible transgenic mouse model for immune mediated hepatitis showing clearance of antigen expressing hepatocytes by CD8+ T cells.

    Directory of Open Access Journals (Sweden)

    Marcin Cebula

    Full Text Available The liver has the ability to prime immune responses against neo antigens provided upon infections. However, T cell immunity in liver is uniquely modulated by the complex tolerogenic property of this organ that has to also cope with foreign agents such as endotoxins or food antigens. In this respect, the nature of intrahepatic T cell responses remains to be fully characterized. To gain deeper insight into the mechanisms that regulate the CD8+ T cell responses in the liver, we established a novel OVA_X_CreER(T2 mouse model. Upon tamoxifen administration OVA antigen expression is observed in a fraction of hepatocytes, resulting in a mosaic expression pattern. To elucidate the cross-talk of CD8+ T cells with antigen-expressing hepatocytes, we adoptively transferred K(b/OVA257-264-specific OT-I T cells to OVA_X_CreER(T2 mice or generated triple transgenic OVA_X CreER(T2_X_OT-I mice. OT-I T cells become activated in OVA_X_CreER(T2 mice and induce an acute and transient hepatitis accompanied by liver damage. In OVA_X_CreER(T2_X_OT-I mice, OVA induction triggers an OT-I T cell mediated, fulminant hepatitis resulting in 50% mortality. Surviving mice manifest a long lasting hepatitis, and recover after 9 weeks. In these experimental settings, recovery from hepatitis correlates with a complete loss of OVA expression indicating efficient clearance of the antigen-expressing hepatocytes. Moreover, a relapse of hepatitis can be induced upon re-induction of cured OVA_X_CreER(T2_X_OT-I mice indicating absence of tolerogenic mechanisms. This pathogen-free, conditional mouse model has the advantage of tamoxifen inducible tissue specific antigen expression that reflects the heterogeneity of viral antigen expression and enables the study of intrahepatic immune responses to both de novo and persistent antigen. It allows following the course of intrahepatic immune responses: initiation, the acute phase and antigen clearance.

  2. Clarithromycin and dexamethasone show similar anti-inflammatory effects on distinct phenotypic chronic rhinosinusitis: an explant model study.

    Science.gov (United States)

    Zeng, Ming; Li, Zhi-Yong; Ma, Jin; Cao, Ping-Ping; Wang, Heng; Cui, Yong-Hua; Liu, Zheng

    2015-06-06

    Phenotype of chronic rhinosinusitis (CRS) may be an important determining factor of the efficacy of anti-inflammatory treatments. Although both glucocorticoids and macrolide antibiotics have been recommended for the treatment of CRS, whether they have different anti-inflammatory functions for distinct phenotypic CRS has not been completely understood. The aim of this study is to compare the anti-inflammatory effects of clarithromycin and dexamethasone on sinonasal mucosal explants from different phenotypic CRS ex vivo. Ethmoid mucosal tissues from CRSsNP patients (n = 15), and polyp tissues from eosinophilic (n = 13) and non-eosinophilic (n = 12) CRSwNP patients were cultured in an ex vivo explant model with or without dexamethasone or clarithromycin treatment for 24 h. After culture, the production and/or expression of anti-inflammatory molecules, epithelial-derived cytokines, pro-inflammatory cytokines, T helper (Th)1, Th2 and Th17 cytokines, chemokines, dendritic cell relevant markers, pattern recognition receptors (PRRs), and tissue remodeling factors were detected in tissue explants or culture supernatants by RT-PCR or ELISA, respectively. We found that both clarithromycin and dexamethasone up-regulated the production of anti-inflammatory mediators (Clara cell 10-kDa protein and interleukin (IL)-10), whereas down-regulated the production of Th2 response and eosinophilia promoting molecules (thymic stromal lymphopoietin, IL-25, IL-33, CD80, CD86, OX40 ligand, programmed cell death ligand 1, CCL17, CCL22, CCL11, CCL5, IL-5, IL-13, and eosinophilic cationic protein) and Th1 response and neutrophilia promoting molecules (CXCL8, CXCL5, CXCL10, CXCL9, interferon-γ, and IL-12), from sinonasal mucosa from distinct phenotypic CRS. In contrast, they had no effect on IL-17A production. The expression of PRRs (Toll-like receptors and melanoma differentiation-associated gene 5) was induced, and the production of tissue remodeling factors (transforming growth factor-β1

  3. Teaching excellence in nursing education: a caring framework.

    Science.gov (United States)

    Sawatzky, Jo-Ann V; Enns, Carol L; Ashcroft, Terri J; Davis, Penny L; Harder, B Nicole

    2009-01-01

    Nursing education plays a central role in the ability to practice effectively. It follows that an optimally educated nursing workforce begets optimal patient care. A framework for excellence in nursing education could guide the development of novice educators, establish the basis for evaluating teaching excellence, and provide the impetus for research in this area. However, a review of the social sciences and nursing literature as well as a search for existing models for teaching excellence revealed an apparent dearth of evidence specific to excellence in nursing education. Therefore, we developed the Caring Framework for Excellence in Nursing Education. This framework evolved from a review of the generic constructs that exemplify teaching excellence: excellence in teaching practice, teaching scholarship, and teaching leadership. Nursing is grounded in the ethic of caring. Hence, caring establishes the foundation for this uniquely nursing framework. Because a teaching philosophy is intimately intertwined with one's nursing philosophy and the ethic of caring, it is also fundamental to the caring framework. Ideally, this framework will contribute to excellence in nursing education and as a consequence excellence in nursing practice and optimal patient care.

  4. Individual Diet Modeling Shows How to Balance the Diet of French Adults with or without Excessive Free Sugar Intakes

    Directory of Open Access Journals (Sweden)

    Anne Lluch

    2017-02-01

    Full Text Available Dietary changes needed to achieve nutritional adequacy for 33 nutrients were determined for 1719 adults from a representative French national dietary survey. For each individual, an iso-energy nutritionally adequate diet was generated using diet modeling, staying as close as possible to the observed diet. The French food composition table was completed with free sugar (FS content. Results were analyzed separately for individuals with FS intakes in their observed diets ≤10% or >10% of their energy intake (named below FS-ACCEPTABLE and FS-EXCESS, respectively. The FS-EXCESS group represented 41% of the total population (average energy intake of 14.2% from FS. Compared with FS-ACCEPTABLE individuals, FS-EXCESS individuals had diets of lower nutritional quality and consumed more energy (2192 vs. 2123 kcal/day, particularly during snacking occasions (258 vs. 131 kcal/day (all p-values < 0.01. In order to meet nutritional targets, for both FS-ACCEPTABLE and FS-EXCESS individuals, the main dietary changes in optimized diets were significant increases in fresh fruits, starchy foods, water, hot beverages and plain yogurts; and significant decreases in mixed dishes/sandwiches, meat/eggs/fish and cheese. For FS-EXCESS individuals only, the optimization process significantly increased vegetables and significantly decreased sugar-sweetened beverages, sweet products and fruit juices. The diets of French adults with excessive intakes of FS are of lower nutritional quality, but can be optimized via specific dietary changes.

  5. Individual Diet Modeling Shows How to Balance the Diet of French Adults with or without Excessive Free Sugar Intakes.

    Science.gov (United States)

    Lluch, Anne; Maillot, Matthieu; Gazan, Rozenn; Vieux, Florent; Delaere, Fabien; Vaudaine, Sarah; Darmon, Nicole

    2017-02-20

    Dietary changes needed to achieve nutritional adequacy for 33 nutrients were determined for 1719 adults from a representative French national dietary survey. For each individual, an iso-energy nutritionally adequate diet was generated using diet modeling, staying as close as possible to the observed diet. The French food composition table was completed with free sugar (FS) content. Results were analyzed separately for individuals with FS intakes in their observed diets ≤10% or >10% of their energy intake (named below FS-ACCEPTABLE and FS-EXCESS, respectively). The FS-EXCESS group represented 41% of the total population (average energy intake of 14.2% from FS). Compared with FS-ACCEPTABLE individuals, FS-EXCESS individuals had diets of lower nutritional quality and consumed more energy (2192 vs. 2123 kcal/day), particularly during snacking occasions (258 vs. 131 kcal/day) (all p-values fresh fruits, starchy foods, water, hot beverages and plain yogurts; and significant decreases in mixed dishes/sandwiches, meat/eggs/fish and cheese. For FS-EXCESS individuals only, the optimization process significantly increased vegetables and significantly decreased sugar-sweetened beverages, sweet products and fruit juices. The diets of French adults with excessive intakes of FS are of lower nutritional quality, but can be optimized via specific dietary changes.

  6. Individual Diet Modeling Shows How to Balance the Diet of French Adults with or without Excessive Free Sugar Intakes

    Science.gov (United States)

    Lluch, Anne; Maillot, Matthieu; Gazan, Rozenn; Vieux, Florent; Delaere, Fabien; Vaudaine, Sarah; Darmon, Nicole

    2017-01-01

    Dietary changes needed to achieve nutritional adequacy for 33 nutrients were determined for 1719 adults from a representative French national dietary survey. For each individual, an iso-energy nutritionally adequate diet was generated using diet modeling, staying as close as possible to the observed diet. The French food composition table was completed with free sugar (FS) content. Results were analyzed separately for individuals with FS intakes in their observed diets ≤10% or >10% of their energy intake (named below FS-ACCEPTABLE and FS-EXCESS, respectively). The FS-EXCESS group represented 41% of the total population (average energy intake of 14.2% from FS). Compared with FS-ACCEPTABLE individuals, FS-EXCESS individuals had diets of lower nutritional quality and consumed more energy (2192 vs. 2123 kcal/day), particularly during snacking occasions (258 vs. 131 kcal/day) (all p-values cheese. For FS-EXCESS individuals only, the optimization process significantly increased vegetables and significantly decreased sugar-sweetened beverages, sweet products and fruit juices. The diets of French adults with excessive intakes of FS are of lower nutritional quality, but can be optimized via specific dietary changes. PMID:28230722

  7. An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model

    Science.gov (United States)

    Kempf, Stefan J.; Metaxas, Athanasios; Ibáñez-Vea, María; Darvesh, Sultan; Finsen, Bente; Larsen, Martin R.

    2016-01-01

    The aim of this study was to elucidate the molecular signature of Alzheimer's disease-associated amyloid pathology. We used the double APPswe/PS1ΔE9 mouse, a widely used model of cerebral amyloidosis, to compare changes in proteome, including global phosphorylation and sialylated N-linked glycosylation patterns, pathway-focused transcriptome and neurological disease-associated miRNAome with age-matched controls in neocortex, hippocampus, olfactory bulb and brainstem. We report that signalling pathways related to synaptic functions associated with dendritic spine morphology, neurite outgrowth, long-term potentiation, CREB signalling and cytoskeletal dynamics were altered in 12 month old APPswe/PS1ΔE9 mice, particularly in the neocortex and olfactory bulb. This was associated with cerebral amyloidosis as well as formation of argyrophilic tangle-like structures and microglial clustering in all brain regions, except for brainstem. These responses may be epigenetically modulated by the interaction with a number of miRNAs regulating spine restructuring, Aβ expression and neuroinflammation. We suggest that these changes could be associated with development of cognitive dysfunction in early disease states in patients with Alzheimer's disease. PMID:27144524

  8. Amniotic fluid stem cells with low γ-interferon response showed behavioral improvement in Parkinsonism rat model.

    Directory of Open Access Journals (Sweden)

    Yu-Jen Chang

    Full Text Available Amniotic fluid stem cells (AFSCs are multipotent stem cells that may be used in transplantation medicine. In this study, AFSCs established from amniocentesis were characterized on the basis of surface marker expression and differentiation potential. To further investigate the properties of AFSCs for translational applications, we examined the cell surface expression of human leukocyte antigens (HLA of these cells and estimated the therapeutic effect of AFSCs in parkinsonian rats. The expression profiles of HLA-II and transcription factors were compared between AFSCs and bone marrow-derived mesenchymal stem cells (BMMSCs following treatment with γ-IFN. We found that stimulation of AFSCs with γ-IFN prompted only a slight increase in the expression of HLA-Ia and HLA-E, and the rare HLA-II expression could also be observed in most AFSCs samples. Consequently, the expression of CIITA and RFX5 was weakly induced by γ-IFN stimulation of AFSCs compared to that of BMMSCs. In the transplantation test, Sprague Dawley rats with 6-hydroxydopamine lesioning of the substantia nigra were used as a parkinsonian-animal model. Following the negative γ-IFN response AFSCs injection, apomorphine-induced rotation was reduced by 75% in AFSCs engrafted parkinsonian rats but was increased by 53% in the control group after 12-weeks post-transplantation. The implanted AFSCs were viable, and were able to migrate into the brain's circuitry and express specific proteins of dopamine neurons, such as tyrosine hydroxylase and dopamine transporter. In conclusion, the relative insensitivity AFSCs to γ-IFN implies that AFSCs might have immune-tolerance in γ-IFN inflammatory conditions. Furthermore, the effective improvement of AFSCs transplantation for apomorphine-induced rotation paves the way for the clinical application in parkinsonian therapy.

  9. An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model.

    Science.gov (United States)

    Krumm, Stefanie A; Yan, Dan; Hovingh, Elise S; Evers, Taylor J; Enkirch, Theresa; Reddy, G Prabhakar; Sun, Aiming; Saindane, Manohar T; Arrendale, Richard F; Painter, George; Liotta, Dennis C; Natchus, Michael G; von Messling, Veronika; Plemper, Richard K

    2014-04-16

    Measles virus is a highly infectious morbillivirus responsible for major morbidity and mortality in unvaccinated humans. The related, zoonotic canine distemper virus (CDV) induces morbillivirus disease in ferrets with 100% lethality. We report an orally available, shelf-stable pan-morbillivirus inhibitor that targets the viral RNA polymerase. Prophylactic oral treatment of ferrets infected intranasally with a lethal CDV dose reduced viremia and prolonged survival. Ferrets infected with the same dose of virus that received post-infection treatment at the onset of viremia showed low-grade viral loads, remained asymptomatic, and recovered from infection, whereas control animals succumbed to the disease. Animals that recovered also mounted a robust immune response and were protected against rechallenge with a lethal CDV dose. Drug-resistant viral recombinants were generated and found to be attenuated and transmission-impaired compared to the genetic parent virus. These findings may pioneer a path toward an effective morbillivirus therapy that could aid measles eradication by synergizing with vaccination to close gaps in herd immunity due to vaccine refusal.

  10. Impact, productivity, and scientific excellence

    CERN Document Server

    Kaur, Jasleen; Menczer, Filippo; Flammini, Alessandro; Radicchi, Filippo

    2014-01-01

    Citation metrics are becoming pervasive in the quantitative evaluation of scholars, journals and institutions. More then ever before, hiring, promotion, and funding decisions rely on a variety of impact metrics that cannot disentangle quality from productivity, and are biased by factors such as discipline and academic age. Biases affecting the evaluation of single papers are compounded when one aggregates citation-based metrics across an entire publication record. It is not trivial to compare the quality of two scholars that during their careers have published at different rates in different disciplines in different periods of time. We propose a novel solution based on the generation of a statistical baseline specifically tailored on the academic profile of each researcher. By decoupling productivity and impact, our method can determine whether a certain level of impact can be explained by productivity alone, or additional ingredients of scientific excellence are necessary. The method is flexible enough to al...

  11. Manufacturing Excellence Approach to Business Performance Model

    OpenAIRE

    Jesus Cruz Alvarez; Carlos Monge Perry

    2015-01-01

    Six Sigma, lean manufacturing, total quality management, quality control, and quality function deployment are the fundamental set of tools to enhance productivity in organizations. There is some research that outlines the benefit of each tool into a particular context of firm´s productivity, but not into a broader context of firm´s competitiveness that is achieved thru business performance. The aim of this theoretical research paper is to contribute to this mean and propose a manufacturing ex...

  12. An Optimal Model to Calculate the Income and Risk of Asset Combined Investments with Excel%应用Excel求解资产组合投资收益与风险的优化模型

    Institute of Scientific and Technical Information of China (English)

    宁云才; 张丽华; 李祥仪

    2001-01-01

    This paper introduces simple programming with VBA which is built in Excel. An optimal model of calculating the income and risk of asset combined investments is illustrated. How to realize repeated problem-solving and result optimization is also presented.%本文结合资产组合投资收益与风险的优化模型的求解,介绍在Excel中可以利用其内嵌的VBA进行简单编程,即可以实现系列化自动反复规划求解、保存优化结果的一些程序化方法和技巧。

  13. Graphing techniques for materials laboratory using Excel

    Science.gov (United States)

    Kundu, Nikhil K.

    1994-01-01

    Engineering technology curricula stress hands on training and laboratory practices in most of the technical courses. Laboratory reports should include analytical as well as graphical evaluation of experimental data. Experience shows that many students neither have the mathematical background nor the expertise for graphing. This paper briefly describes the procedure and data obtained from a number of experiments such as spring rate, stress concentration, endurance limit, and column buckling for a variety of materials. Then with a brief introduction to Microsoft Excel the author explains the techniques used for linear regression and logarithmic graphing.

  14. Data analysis for physical scientists featuring Excel

    CERN Document Server

    Kirkup, Les

    2012-01-01

    The ability to summarise data, compare models and apply computer-based analysis tools are vital skills necessary for studying and working in the physical sciences. This textbook supports undergraduate students as they develop and enhance these skills. Introducing data analysis techniques, this textbook pays particular attention to the internationally recognised guidelines for calculating and expressing measurement uncertainty. This new edition has been revised to incorporate Excel® 2010. It also provides a practical approach to fitting models to data using non-linear least squares, a powerful technique which can be applied to many types of model. Worked examples using actual experimental data help students understand how the calculations apply to real situations. Over 200 in-text exercises and end-of-chapter problems give students the opportunity to use the techniques themselves and gain confidence in applying them. Answers to the exercises and problems are given at the end of the book.

  15. ITMO Photonics: center of excellence

    Science.gov (United States)

    Voznesenskaya, Anna; Bougrov, Vladislav; Kozlov, Sergey; Vasilev, Vladimir

    2016-09-01

    ITMO University, the leading Russian center in photonics research and education, has the mission to train highlyqualified competitive professionals able to act in conditions of fast-changing world. This paradigm is implemented through creation of a strategic academic unit ITMO Photonics, the center of excellence concentrating organizational, scientific, educational, financial, laboratory and human resources. This Center has the following features: dissemination of breakthrough scientific results in photonics such as advanced photonic materials, ultrafast optical and quantum information, laser physics, engineering and technologies, into undergraduate and graduate educational programs through including special modules into the curricula and considerable student's research and internships; transformation of the educational process in accordance with the best international educational practices, presence in the global education market in the form of joint educational programs with leading universities, i.e. those being included in the network programs of international scientific cooperation, and international accreditation of educational programs; development of mechanisms for the commercialization of innovative products - results of scientific research; securing financial sustainability of research in the field of photonics of informationcommunication systems via funding increase and the diversification of funding sources. Along with focusing on the research promotion, the Center is involved in science popularization through such projects as career guidance for high school students; interaction between student's chapters of international optical societies; invited lectures of World-famous experts in photonics; short educational programs in optics, photonics and light engineering for international students; contests, Olympics and grants for talented young researchers; social events; interactive demonstrations.

  16. Comments on the Paper `A new basic 1-dimensional 1-layer model obtains excellent agreement with the observed Earth temperature' by Rainer Link and Horst-Joachim L\\"udecke

    CERN Document Server

    Kramm, Gerhard

    2011-01-01

    In our comments on the paper of Link and L\\"udecke we document that these authors used rather improper quotations of our paper. They also argued on the basis of false claims regarding our mathematical and physical description of both the global energy balance model of Schneider and Mass and the Dines-type two-layer energy balance model for the Earth-atmosphere system. They completely disregarded the respective literature. They claimed excellent agreement between their predicted Earth's surface temperature and the observed one even though they only reproduced the temperature by an inverse application of the power law of Stefan and Boltzmann. They also claimed that their result for the increase in the Earth's surface temperature of about 1.1 K due to the doubling of the atmospheric CO2 concentration is in good agreement with the IPCC value if no feedback is considered. However, beside the fact that this result is not based on model predictions, it also disagrees with the definition of the anthropogenic radiativ...

  17. Realisatie van Excel Kwadraat in de praktijk

    NARCIS (Netherlands)

    Dijkstra, Elma

    2013-01-01

    Dijkstra, E. M. (2013, 2 July). Realisatie van Excel Kwadraat in de praktijk [Realization of Excellent Education in practice]. Presentation held at the OLK-meeting, ITS, Radboud University, Nijmegen, The Netherlands.

  18. Business excellence journey in countries in transition

    Directory of Open Access Journals (Sweden)

    Pavel Castka

    2001-01-01

    Full Text Available This paper describes the journey toward business excellence regarding the influence of the contemporary global environment, as well as the specifics of the environment in countries in transition (the environment in the Czech Republic is taken as a representative model. Closer focus is given on problems connected with productivity, effectivity, innovation, quality and certification, use of IT/IS and on problems with participation of employees. The abovementioned characteristics make up the goals of a change to a process-oriented company. In regard of business downturn in many companies in the post-communist environment, these goals are achievable by radical change using the ideas of Business Process Reengineering (BPR and the process-oriented model described at the end of this paper.

  19. BENCHMARKING WORKSHOPS AS A TOOL TO RAISE BUSINESS EXCELLENCE

    Directory of Open Access Journals (Sweden)

    Milos Jelic

    2011-03-01

    Full Text Available Annual competition for national award for business excellence appears to be a good opportunity for participating organizations to demonstrate their practices particularly those ones which enable them to excel. National quality award competition in Serbia (and Montenegro, namely "OSKAR KVALITETA" started in 1995 but was limited to competition cycle only. However, upon establishing Fund for Quality Culture and Excellence - FQCE in 2002, which took over OSKAR KVALITETA model, several changes took place. OSKAR KVALITETA turned to be annual competition in business excellence, but at the same time FQCE started to offer much wider portfolio of its services including levels of excellence programs, assessment and self-assessment training courses and benchmarking workshops. These benchmarking events have hosted by Award winners or other laureates in OSKAR KVALITETA competition who demonstrated excellence in regard of some particular criteria thus being in position to share their practice with other organizations. For six years experience in organizing benchmarking workshops FQCE scored 31 workshops covering major part of model issues. Increasing level of participation on the workshops and distinct positive trends of participants expressed satisfaction may serve as a reliable indicator that the workshops have been effective in actuating people to think and move in business excellence direction.

  20. Tutorial: simulating chromatography with Microsoft Excel Macros.

    Science.gov (United States)

    Kadjo, Akinde; Dasgupta, Purnendu K

    2013-04-22

    Chromatography is one of the cornerstones of modern analytical chemistry; developing an instinctive feeling for how chromatography works will be invaluable to future generation of chromatographers. Specialized software programs exist that handle and manipulate chromatographic data; there are also some that simulate chromatograms. However, the algorithm details of such software are not transparent to a beginner. In contrast, how spreadsheet tools like Microsoft Excel™ work is well understood and the software is nearly universally available. We show that the simple repetition of an equilibration process at each plate (a spreadsheet row) followed by discrete movement of the mobile phase down by a row, easily automated by a subroutine (a "Macro" in Excel), readily simulates chromatography. The process is readily understood by a novice. Not only does this permit simulation of isocratic and simple single step gradient elution, linear or multistep gradients are also easily simulated. The versatility of a transparent and easily understandable computational platform further enables the simulation of complex but commonly encountered chromatographic scenarios such as the effects of nonlinear isotherms, active sites, column overloading, on-column analyte degradation, etc. These are not as easily simulated by available software. Views of the separation as it develops on the column and as it is seen by an end-column detector are both available in real time. Excel 2010™ also permits a 16-level (4-bit) color gradation of numerical values in a column/row; this permits visualization of a band migrating down the column, much as Tswett may have originally observed, but in a numerical domain. All parameters of relevance (partition constants, elution conditions, etc.) are readily changed so their effects can be examined. Illustrative Excel spreadsheets are given in the Supporting Information; these are easily modified by the user or the user can write his/her own routine.

  1. Techniques for managing behaviour in pediatric dentistry: comparative study of live modelling and tell-show-do based on children's heart rates during treatment.

    Science.gov (United States)

    Farhat-McHayleh, Nada; Harfouche, Alice; Souaid, Philippe

    2009-05-01

    Tell-show-do is the most popular technique for managing children"s behaviour in dentists" offices. Live modelling is used less frequently, despite the satisfactory results obtained in studies conducted during the 1980s. The purpose of this study was to compare the effects of these 2 techniques on children"s heart rates during dental treatments, heart rate being the simplest biological parameter to measure and an increase in heart rate being the most common physiologic indicator of anxiety and fear. For this randomized, controlled, parallel-group single-centre clinical trial, children 5 to 9 years of age presenting for the first time to the Saint Joseph University dental care centre in Beirut, Lebanon, were divided into 3 groups: those in groups A and B were prepared for dental treatment by means of live modelling, the mother serving as the model for children in group A and the father as the model for children in group B. The children in group C were prepared by a pediatric dentist using the tell-show-do method. Each child"s heart rate was monitored during treatment, which consisted of an oral examination and cleaning. A total of 155 children met the study criteria and participated in the study. Children who received live modelling with the mother as model had lower heart rates than those who received live modelling with the father as model and those who were prepared by the tell-show-do method (p dentistry.

  2. An Excel macro for generating trilinear plots.

    Science.gov (United States)

    Shikaze, Steven G; Crowe, Allan S

    2007-01-01

    This computer note describes a method for creating trilinear plots in Microsoft Excel. Macros have been created in MS Excel's internal language: Visual Basic for Applications (VBA). A simple form has been set up to allow the user to input data from an Excel worksheet. The VBA macro is used to convert the triangular data (which consist of three columns of percentage data) into X-Y data. The macro then generates the axes, labels, and grid for the trilinear plot. The X-Y data are plotted as scatter data in Excel. By providing this macro in Excel, users can create trilinear plots in a quick, inexpensive manner.

  3. BUSINESS EXCELLENCE AS A CRUCIAL COMPONENT FOR ORGANIZATION COMPETITIVENESS

    OpenAIRE

    Zeljko Pozega; Boris Crnkovic; Ana Udovicic

    2014-01-01

    Background: Business excellence represents one of the most valuable management means of achieving competitive advantage of organizations. Modern and global market demands new organizational approaches for the long-term improvement at all organization levels. Objectives: This paper is concerned with the level of business excellence in Sibenik-Knin County and the level of knowledge about the EFQM model. Moreover, this paper is concerned with the level of knowledge of the top management concerni...

  4. The Brain Bowl: Competitive Excellence.

    Science.gov (United States)

    Raepple, Roger R.; Ehlert, David L.

    1984-01-01

    Describes the Florida Community College Brain Bowl, as a model for recognizing outstanding academic achievement, in a contest in which two competing community college teams answer faculty-prepared questions from various disciplines. (DMM)

  5. Redesigning Schools to Reach Every Student with Excellent Teachers: Summary of Teacher Career Paths

    Science.gov (United States)

    Public Impact, 2012

    2012-01-01

    These career paths match Public Impact's school models that use job redesign and technology to extend the reach of excellent teachers to more students, for more pay, within budget. Most models create new roles and teams enabling all teachers and staff to develop and contribute to excellence. In "reach-extended roles," excellent teachers…

  6. Physically and chemically stable ionic liquid-infused textured surfaces showing excellent dynamic omniphobicity

    Directory of Open Access Journals (Sweden)

    Daniel F. Miranda

    2014-05-01

    Full Text Available A fluorinated and hydrophobic ionic liquid (IL, 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl imide, effectively served as an advantageous lubricating liquid for the preparation of physically and chemically stable omniphobic surfaces based on slippery liquid-infused porous surfaces. Here, we used particulate microstructures as supports, prepared by the chemical vapor deposition of 1,3,5,7-tetramethylcyclotetrasiloxane and subsequent surface modification with (3-aminopropyltriethoxysilane. Confirmed by SEM and contact angle measurements, the resulting IL-infused microtextured surfaces are smooth and not only water but also various low surface tension liquids can easily slide off at low substrate tilt angles of <5°, even after exposure to high temperature, vacuum, and UV irradiation.

  7. Physically and chemically stable ionic liquid-infused textured surfaces showing excellent dynamic omniphobicity

    Energy Technology Data Exchange (ETDEWEB)

    Miranda, Daniel F.; Urata, Chihiro; Masheder, Benjamin; Dunderdale, Gary J.; Hozumi, Atsushi, E-mail: a.hozumi@aist.go.jp [National Institute of Advanced Industrial Science and Technology (AIST), 2266-98, Anagahora, Shimo-Shidami, Moriyama-ku, Nagoya, Aichi 463-8560 (Japan); Yagihashi, Makoto [Nagoya Municipal Industrial Research Institute, Rokuban, Atsuta-ku, Nagoya 456-0058 (Japan)

    2014-05-01

    A fluorinated and hydrophobic ionic liquid (IL), 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl) imide, effectively served as an advantageous lubricating liquid for the preparation of physically and chemically stable omniphobic surfaces based on slippery liquid-infused porous surfaces. Here, we used particulate microstructures as supports, prepared by the chemical vapor deposition of 1,3,5,7-tetramethylcyclotetrasiloxane and subsequent surface modification with (3-aminopropyl)triethoxysilane. Confirmed by SEM and contact angle measurements, the resulting IL-infused microtextured surfaces are smooth and not only water but also various low surface tension liquids can easily slide off at low substrate tilt angles of <5°, even after exposure to high temperature, vacuum, and UV irradiation.

  8. Longfeng Textile Strives for Excellence

    Institute of Scientific and Technical Information of China (English)

    Zhao Fei

    2011-01-01

    The reporter of the magazine found an opportunity to have an interview with Wu Xiujian, vice- general manager of Longfeng Textile, in terms of its products, marketing, competitive advantages, the feeling of the show, etc.

  9. Viral Innovation, Sustainability, and Excellence

    DEFF Research Database (Denmark)

    Edgeman, Rick; Eskildsen, Jacob Kjær

    Enterprises strive to be economically sustainable. In doing so, they either contribute to or detract from environmental and social sustainability. Sustainability is hence multi-dimensional with formulations that include the familiar triple-bottom-line and BEST models. Any assessment regimen...... and practices into enterprises and is spearheaded by the Interdisciplinary Center for Organizational Architecture at Aarhus University (Denmark), the Center for Research in Organization& Management at Bocconi University (Italy), Vienna University of Economics & Business (Austria), and the Northstar Initiative...... for these models include Biophysical/Environmental, Business/Economic, and Societal dimensions with the BEST model adding a Technological dimension that refers predominantly to infrastructure, that is, to the built-environment. Integration across these sustainability dimensions is challenging, but can...

  10. Pension fund excellence creating value for stakeholders

    CERN Document Server

    Ambachtsheer, Keith P.

    1998-01-01

    Internationally recognized experts in the field introduce their "business excellence paradigm". In this book, two leading pension fund experts lay out a comprehensive plan for effective fund management. With the help of domestic and global case studies they critically assess current approaches to pension fund management and isolate what works and what doesn't using their unique critically acclaimed "run-it-like-a-business" model. Keith P. Ambachtsheer (Toronto, Canada) is principle at KPA Advisory Service, Inc., a pension fund management consulting firm. He runs The Ambachtsheer Letter and cofounded Cost Effective Measurement, Inc., which monitors the performance of 300 of the world's largest asset funds. D. Don Ezra (Toronto, Canada) is Director of European Consulting at Frank Russell Co. His previous books include The Struggle for Pension Fund Wealth.

  11. Viral Innovation, Sustainability, and Excellence

    DEFF Research Database (Denmark)

    Edgeman, Rick; Eskildsen, Jacob Kjær

    Enterprises strive to be economically sustainable. In doing so, they either contribute to or detract from environmental and social sustainability. Sustainability is hence multi-dimensional with formulations that include the familiar triple-bottom-line and BEST models. Any assessment regimen for t...

  12. Perform data envelopment analysis in MS Excel based on models of C2R and C2GS2%Excel VBA基于C2R和C2GS2模型实现数据包络分析的方法

    Institute of Scientific and Technical Information of China (English)

    章燕丽; 李显文; 高越明; 吕旭东

    2008-01-01

    数据包络分析用来评价具有多输入、多输出的决策单元之间的相对有效性.本文基于两个DEA数学模型C2R和C2GS2的等价线性规划模型,利用Fxcel 2003强大的数字处理分析功能并结合其线性规划求解工具,运用Excel VBA语言实现了一种使用简单方便的DEA分析方法.

  13. The application of Excel-based financial modeling in calculating financing lease%基于Excel的财务建模在融资租赁计算中的应用

    Institute of Scientific and Technical Information of China (English)

    何学武; 刘灿红

    2014-01-01

    The Accounting Standards for Enterprises No.21-Leases specifies enterprises should adopt actual interest rate method to share the unrecognized financing fees for financing leasing assets during the lease term. It's complex and inaccurate to caculate the share of terminal financial charges by hands,the Excel-based financial modeling can solve these problems clearly and is convenient for financial staff to deal with this kind of business.%《企业会计准则第21号--租赁》规定,在租赁期内,企业要采用实际利率法分摊融资租入资产的未确认融资费用。在手工方式下计算每期应确认的融资费用分摊额既复杂又不准确,利用Excel财务建模建立计算模型,可巧妙地解决这一问题,为会计实务工作者处理此类业务带来方便。

  14. Measuring research excellence in the EU

    DEFF Research Database (Denmark)

    Sørensen, Mads P.; Bloch, Carter Walter; Young, Mitchell

    In 2013, the European Union unveiled its new ‘Composite Indicator for Scientific and Technological Research Excellence’, marking a turning point in how excellence is understood and used in European policy. This is not an isolated occurrence; policy-based interest in excellence is growing all over...... the world. The heightened focus on excellence and in particular, attempts to define it through quantitative indicators can have important implications for research policy and for the conduct of research itself. This paper examines how the European Union’s understanding of excellence has evolved in recent...... years, from the presentation of the Lisbon strategy in 2000 to the current Europe 2020 strategy. We find a distinct shift in the understanding of excellence and how success in the knowledge-based economy should be achieved: in the early period, excellence is a fuzzy concept, intrinsically embedded...

  15. An integrated model of transcription factor diffusion shows the importance of intersegmental transfer and quaternary protein structure for target site finding.

    Directory of Open Access Journals (Sweden)

    Hugo G Schmidt

    Full Text Available We present a computational model of transcription factor motion that explains both the observed rapid target finding of transcription factors, and how this motion influences protein and genome structure. Using the Smoldyn software, we modelled transcription factor motion arising from a combination of unrestricted 3D diffusion in the nucleoplasm, sliding along the DNA filament, and transferring directly between filament sections by intersegmental transfer. This presents a fine-grain picture of the way in which transcription factors find their targets two orders of magnitude faster than 3D diffusion alone allows. Eukaryotic genomes contain sections of nucleosome free regions (NFRs around the promoters; our model shows that the presence and size of these NFRs can be explained as their acting as antennas on which transcription factors slide to reach their targets. Additionally, our model shows that intersegmental transfer may have shaped the quaternary structure of transcription factors: sequence specific DNA binding proteins are unusually enriched in dimers and tetramers, perhaps because these allow intersegmental transfer, which accelerates target site finding. Finally, our model shows that a 'hopping' motion can emerge from 3D diffusion on small scales. This explains the apparently long sliding lengths that have been observed for some DNA binding proteins observed in vitro. Together, these results suggest that transcription factor diffusion dynamics help drive the evolution of protein and genome structure.

  16. Investigating Complexity Using Excel and Visual Basic.

    Science.gov (United States)

    Zetie, K. P.

    2001-01-01

    Shows how some of the simple ideas in complexity can be investigated using a spreadsheet and a macro written in Visual Basic. Shows how the sandpile model of Bak, Chao, and Wiesenfeld can be simulated and animated. The model produces results that cannot easily be predicted from its properties. (Author/MM)

  17. 信息熵赋权的大学生综合素质评价模型的EXCEL求解%The Information Entropy Empowerment of College Students Comprehensive Quality Evaluation Model of EXCEL to Solve

    Institute of Scientific and Technical Information of China (English)

    陈华喜; 许庆兵; 姚保峰

    2012-01-01

    How to scientifically evaluate the comprehensive quality of college students in colleges and uni-versities is the presence of a urgent problem to be solved. Based on comprehensive, feasibility, level and principle of using accelerating genetic algorithm based on the fuzzy analytic hierarchy process (ahp) after screening index construction of college students comprehensive quality evaluation index system, with the objective based on entropy weight method to weighting at all levels, and combining the fuzzy comprehen- sive evaluation method to establish a college students' comprehensive quality evaluation model, and finally gives out the model of solving method EXCEL.%如何科学地评价大学生的综合素质是摆在当前高等院校面前的一个亟待解决的问题.本文依据全面性、可行性、层次性等原则,对基于加速遗传算法的模糊层次分析法筛选指标后构建的大学生综合素质评价指标体系,用基于信息熵的客观赋权方法对各级指标赋权,进而结合模糊综合评判法建立了一个大学生综合素质评价模型,最后给出了该模型的EXCEL求解方法.

  18. Technical Excellence: A Requirement for Good Engineering

    Science.gov (United States)

    Gill, Paul S.; Vaughan, William W.

    2008-01-01

    Technical excellence is a requirement for good engineering. Technical excellence has many different ways of expressing itself within engineering. NASA has initiatives that address the enhancement of the Agency's technical excellence and thrust to maintain the associated high level of performance by the Agency on current programs/projects and as it moves into the Constellation Program and the return to the Moon with plans to visit Mars. This paper addresses some of the key initiatives associated with NASA's technical excellence thrust. Examples are provided to illustrate some results being achieved and plans to enhance these initiatives.

  19. Excel 2003 Power Programming with VBA

    CERN Document Server

    Walkenbach, John

    2008-01-01

    "Today, no accomplished Excel programmer can afford to be without John's book. The value of Excel 2003 Power Programming with VBA is double most other books-simultaneously the premier reference and best learning tool for Excel VBA."--Loren Abdulezer, Author of Excel Best Practices for BusinessEverything you need to know about:* Creating stellar UserForms and custom dialog box alternatives * Working with VBA subprocedures and function procedures * Incorporating event-handling and interactions with other applications * Building user-friendly toolbars, menus, and help systems * Manipulating files

  20. What every engineer should know about excel

    CERN Document Server

    Holman, J P

    2006-01-01

    INTRODUCTIONGetting the Most from ExcelConventionsOutline of MISCELLANEOUS OPERATIONS IN EXCEL AND WORDIntroductionPrint Screen or Screen DumpCustom Keyboard Setup for Symbols in WordViewing or Printing Column and Row Headings and Gridlines in ExcelAssorted InstructionsMoving Objects in Small Increments (Nudging)Formatting Objects in Word, Including WrappingFormatting Objects in ExcelUse of Photo-Editing Software in Word, Including WrappingCopying Cell Formulas: Effect of Relative and Absolute AddressesCopying Formulas by Dragging the Fill HandleShortcut for Changing the Status of Cell Address

  1. Bayesian Analysis Made Simple An Excel GUI for WinBUGS

    CERN Document Server

    Woodward, Philip

    2011-01-01

    From simple NLMs to complex GLMMs, this book describes how to use the GUI for WinBUGS - BugsXLA - an Excel add-in written by the author that allows a range of Bayesian models to be easily specified. With case studies throughout, the text shows how to routinely apply even the more complex aspects of model specification, such as GLMMs, outlier robust models, random effects Emax models, auto-regressive errors, and Bayesian variable selection. It provides brief, up-to-date discussions of current issues in the practical application of Bayesian methods. The author also explains how to obtain free so

  2. The Pursuit of Excellence through Education.

    Science.gov (United States)

    Ferrari, Michel, Ed.

    In this book theorists and researchers present a range of perspectives on how to promote excellence in education, providing an opportunity for expression to those who stress transformation of educational practice and those who emphasize individual abilities. In part 1, The Individual Pursuit of Excellence, the chapters are: (1) Learning from…

  3. Getting the Best out of Excel

    Science.gov (United States)

    Heys, Chris

    2008-01-01

    Excel, Microsoft's spreadsheet program, offers several tools which have proven useful in solving some optimization problems that arise in operations research. We will look at two such tools, the Excel modules called Solver and Goal Seek--this after deriving an equation, called the "cash accumulation equation", to be used in conjunction with them.

  4. Standards of Excellence in Budget Presentation.

    Science.gov (United States)

    Bolton, Denny G.; Harmer, W. Gary

    This guide describes the Meritorious Budget Awards Program recognizing excellence in school system budgeting awarded by the Association of School Business Officials. The award is designed to help school business administrators achieve a high standard of excellence in budget presentations. Chapters provide the expectations and relevant criteria…

  5. Using Microsoft Excel to Generate Usage Statistics

    Science.gov (United States)

    Spellman, Rosemary

    2011-01-01

    At the Libraries Service Center, statistics are generated on a monthly, quarterly, and yearly basis by using four Microsoft Excel workbooks. These statistics provide information about what materials are being requested and by whom. They also give details about why certain requests may not have been filled. Utilizing Excel allows for a shallower…

  6. Animating ground water levels with Excel.

    Science.gov (United States)

    Shikaze, Steven G; Crowe, Allan S

    2003-01-01

    This note describes the use of Microsoft Excel macros (programs written in Excel's internal language, Visual Basic for Applications) to create simple onscreen animations of transient ground water data within Excel. Compared to many specialized visualization software packages, the use of Excel macros is much cheaper, much simpler, and can rapidly be learned. The Excel macro can also be used to create individual GIF files for each animation frame. This series of frames can then be used to create an AVI video file using any of a number of graphics packages, such as Corel PhotoPaint. The technique is demonstrated through a macro that animates changes in the elevation of a water table along a transect over several years.

  7. From VBA to VSTO Is Excel's New Engine Right for You?

    CERN Document Server

    Verschuuren, Dr Gerard M

    2006-01-01

    This Excel user's guide to VSTO-the new Excel Macro programming language being promoted by Microsoft-shows how to perform the equivalent VBA actions with VSTO. The differences between the VSTO and VBA development environments are explained, helping Excel users decide if they should embrace VSTO or seek out other technologies.

  8. TOP PRIORITI QMS PRINCIPLES FOR ACHIEVING BUSINESS EXCELLENCE

    Directory of Open Access Journals (Sweden)

    Aleksandar Vujović

    2010-06-01

    Full Text Available The main target of this paper is to select top priority principles of QMS for achieving business excellence. This could be done from the standpoint of significant of principles. That means that. organization should make more attention to this principles in the way for making excellent results. This paper has been developed as a tendency of researchers in the Center for quality-Faculty of mechanical engineering in Podgorica to establish a model for improvement of business processes performances based on quality management system through comparison with top organizational performances characterized by criteria i.e. particularities of the business excellence model. Correlation of principles of the quality management system with QMS principles has been established to that effect. Weight coefficients have been also determined for each principle individually. Thereby key principles were identified, namely priorities in terms of achieving business excellence i.e. areas (principles were given priorities, that is to say principles that play the biggest part in achieving business excellence.

  9. Advanced Excel for scientific data analysis

    CERN Document Server

    De Levie, Robert

    2004-01-01

    Excel is by far the most widely distributed data analysis software but few users are aware of its full powers. Advanced Excel For Scientific Data Analysis takes off from where most books dealing with scientific applications of Excel end. It focuses on three areas-least squares, Fourier transformation, and digital simulation-and illustrates these with extensive examples, often taken from the literature. It also includes and describes a number of sample macros and functions to facilitate common data analysis tasks. These macros and functions are provided in uncompiled, computer-readable, easily

  10. Microsoft Office Excel 2003 Inside Out

    CERN Document Server

    Stinson, Craig

    2003-01-01

    Hey, you know your way around a spreadsheet-so now dig into Excel 2003 and really put your data to work! This supremely organized reference packs hundreds of timesaving solutions, troubleshooting tips, and handy workarounds in concise, fast-answer format. It's all muscle and no fluff. Discover the best and fastest ways to perform everyday tasks, and challenge yourself to new levels of Excel mastery! Build on what you already know about Excel and quickly dive into what's newLearn how the experts design more powerful spreadsheetsSharpen your core to advanced document editing and formatting skil

  11. Promoting sustainable excellence through diversity in research careers

    CERN Document Server

    CERN. Geneva; Dr. Vinkenburg, Claartje; Guinot, Genevieve

    2015-01-01

    Excellence is a non-negotiable in science, a necessary condition for a successful careers as well as the funding of research projects. Scientific excellence is the sole criterion used by the European Research Council (ERC) to award frontier research grants. However, statistics show that there are still persistent inequalities between men and women scientists in ERC funding success as well as other career outcomes. Dr. Claartje Vinkenburg, of the VU University of Amsterdam, will illustrate two projects commissioned by the ERC Gender Balance Working Group to uncover and address this phenomenon. The first project [ERCAREER (Vinkenburg PI, 2012-2014)] is about unconventional careers and career breaks, and studies the gendered nature of career paths of ERC applicants. Findings show that “conventional careers” in science are inextricably tied to normative beliefs about the ideal academic, mobility, independence, and excellence. Allowing unconventional careers to address the issue results in ir...

  12. Excellence in the Knowledge-Based Economy: From Scientific to Research Excellence

    Science.gov (United States)

    Sørensen, Mads P.; Bloch, Carter; Young, Mitchell

    2016-01-01

    In 2013, the European Union (EU) unveiled its new "Composite Indicator for Scientific and Technological Research Excellence." This is not an isolated occurrence; policy-based interest in excellence is growing all over the world. The heightened focus on excellence and, in particular, attempts to define it through quantitative indicators…

  13. What Makes an Excellent Lecturer? Academics' Perspectives on the Discourse of "Teaching Excellence" in Higher Education

    Science.gov (United States)

    Wood, Margaret; Su, Feng

    2017-01-01

    In the context of the Teaching Excellence Framework (TEF), we examine academics' perspectives on the discourse of "teaching excellence" based on an empirical study with 16 participants from five post-1992 universities. The article reports the findings on academics' views of the term and concept of "teaching excellence",…

  14. A Multiple siRNA-Based Anti-HIV/SHIV Microbicide Shows Protection in Both In Vitro and In Vivo Models.

    Directory of Open Access Journals (Sweden)

    Sandhya Boyapalle

    Full Text Available Human immunodeficiency virus (HIV types 1 and 2 (HIV-1 and HIV-2 are the etiologic agents of AIDS. Most HIV-1 infected individuals worldwide are women, who acquire HIV infections during sexual contact. Blocking HIV mucosal transmission and local spread in the female lower genital tract is important in preventing infection and ultimately eliminating the pandemic. Microbicides work by destroying the microbes or preventing them from establishing an infection. Thus, a number of different types of microbicides are under investigation, however, the lack of their solubility and bioavailability, and toxicity has been major hurdles. Herein, we report the development of multifunctional chitosan-lipid nanocomplexes that can effectively deliver plasmids encoding siRNA(s as microbicides without adverse effects and provide significant protection against HIV in both in vitro and in vivo models. Chitosan or chitosan-lipid (chlipid was complexed with a cocktail of plasmids encoding HIV-1-specific siRNAs (psiRNAs and evaluated for their efficacy in HEK-293 cells, PBMCs derived from nonhuman primates, 3-dimensional human vaginal ectocervical tissue (3D-VEC model and also in non-human primate model. Moreover, prophylactic administration of the chlipid to deliver a psiRNA cocktail intravaginally with a cream formulation in a non-human primate model showed substantial reduction of SHIV (simian/human immunodeficiency virus SF162 viral titers. Taken together, these studies demonstrate the potential of chlipid-siRNA nanocomplexes as a potential genetic microbicide against HIV infections.

  15. A Multiple siRNA-Based Anti-HIV/SHIV Microbicide Shows Protection in Both In Vitro and In Vivo Models.

    Science.gov (United States)

    Boyapalle, Sandhya; Xu, Weidong; Raulji, Payal; Mohapatra, Subhra; Mohapatra, Shyam S

    2015-01-01

    Human immunodeficiency virus (HIV) types 1 and 2 (HIV-1 and HIV-2) are the etiologic agents of AIDS. Most HIV-1 infected individuals worldwide are women, who acquire HIV infections during sexual contact. Blocking HIV mucosal transmission and local spread in the female lower genital tract is important in preventing infection and ultimately eliminating the pandemic. Microbicides work by destroying the microbes or preventing them from establishing an infection. Thus, a number of different types of microbicides are under investigation, however, the lack of their solubility and bioavailability, and toxicity has been major hurdles. Herein, we report the development of multifunctional chitosan-lipid nanocomplexes that can effectively deliver plasmids encoding siRNA(s) as microbicides without adverse effects and provide significant protection against HIV in both in vitro and in vivo models. Chitosan or chitosan-lipid (chlipid) was complexed with a cocktail of plasmids encoding HIV-1-specific siRNAs (psiRNAs) and evaluated for their efficacy in HEK-293 cells, PBMCs derived from nonhuman primates, 3-dimensional human vaginal ectocervical tissue (3D-VEC) model and also in non-human primate model. Moreover, prophylactic administration of the chlipid to deliver a psiRNA cocktail intravaginally with a cream formulation in a non-human primate model showed substantial reduction of SHIV (simian/human immunodeficiency virus SF162) viral titers. Taken together, these studies demonstrate the potential of chlipid-siRNA nanocomplexes as a potential genetic microbicide against HIV infections.

  16. Introduction to statistics using Microsoft Excel

    CERN Document Server

    Remenyi, Dan; English, Joseph

    2011-01-01

    This book explains the statistical concepts and then uses Microsoft Excel functions to illustrate how to get results using the appropriate techniques which will help researchers directly with their research.

  17. Fostering a culture of service excellence.

    Science.gov (United States)

    Lasserre, Christine

    2010-01-01

    Patients' level of satisfaction with healthcare providers can have profound implications for operational and clinical outcomes. Are your organizational leaders fostering a practice culture of "service excellence"? Has your organization defined what "service excellence" means? Do your employees have a clear understanding of your expectations for service delivery? Medical practice leaders can improve patients' level of satisfaction by adopting and fostering a culture of service excellence in their practice. Strengthening the practice-patient relationship through patient-service initiatives can lead to improved patient perception of care quality and overall satisfaction with their healthcare providers. When patients feel wanted and well cared for by their healthcare providers, they are less likely to be noncompliant and more likely to achieve positive clinical outcomes. Operationally, service-excellence initiatives will have a profound impact on patient retention and new referrals, and possibly a reduction of litigious risks.

  18. A proposed adaptation of the European Foundation for Quality Management Excellence Model to physical activity programmes for the elderly - development of a quality self-assessment tool using a modified Delphi process

    Directory of Open Access Journals (Sweden)

    Marques Ana I

    2011-09-01

    Full Text Available Abstract Background There has been a growing concern in designing physical activity (PA programmes for elderly people, since evidence suggests that such health promotion interventions may reduce the deleterious effects of the ageing process. Complete programme evaluations are a necessary prerequisite to continuous quality improvements. Being able to refine, adapt and create tools that are suited to the realities and contexts of PA programmes for the elderly in order to support its continuous improvement is, therefore, crucial. Thus, the aim of this study was to develop a self-assessment tool for PA programmes for the elderly. Methods A 3-round Delphi process was conducted via the Internet with 43 national experts in PA for the elderly, management and delivery of PA programmes for the elderly, sports management, quality management and gerontology, asking experts to identify the propositions that they considered relevant for inclusion in the self-assessment tool. Experts reviewed a list of proposed statements, based on the criteria and sub-criteria from the European Foundation for Quality Management Excellence Model (EFQM and PA guidelines for older adults and rated each proposition from 1 to 8 (disagree to agree and modified and/or added propositions. Propositions receiving either bottom or top scores of greater than 70% were considered to have achieved consensus to drop or retain, respectively. Results In round 1, of the 196 originally-proposed statements (best practice principles, the experts modified 41, added 1 and achieved consensus on 93. In round 2, a total of 104 propositions were presented, of which experts modified 39 and achieved consensus on 53. In the last round, of 51 proposed statements, the experts achieved consensus on 19. After 3 rounds of rating, experts had not achieved consensus on 32 propositions. The resulting tool consisted of 165 statements that assess nine management areas involved in the development of PA programmes for

  19. Limitations of Using Microsoft Excel Version 2016 (MS Excel 2016) for Statistical Analysis for Medical Research.

    Science.gov (United States)

    Tanavalee, Chotetawan; Luksanapruksa, Panya; Singhatanadgige, Weerasak

    2016-06-01

    Microsoft Excel (MS Excel) is a commonly used program for data collection and statistical analysis in biomedical research. However, this program has many limitations, including fewer functions that can be used for analysis and a limited number of total cells compared with dedicated statistical programs. MS Excel cannot complete analyses with blank cells, and cells must be selected manually for analysis. In addition, it requires multiple steps of data transformation and formulas to plot survival analysis graphs, among others. The Megastat add-on program, which will be supported by MS Excel 2016 soon, would eliminate some limitations of using statistic formulas within MS Excel.

  20. Core values: the pre-condition for Business Excellence

    DEFF Research Database (Denmark)

    Dahlgaard, Su Mi Park; Dahlgaard, Jens Jørn; Edgeman, Rick L.

    1998-01-01

    Systemic leadership deployment for Business Excellence demands transformation of our mental models. This requires a profound understanding of so called core values (intangibles) and their relation to the traditional tangibles (goals and core competencies). Often these core values are not clearly...... identified and they are seldom deployed with the same enthusiasm as the goals and core competencies needed for Business Excellence. It is assumed herein that if core values are neglected in the policy deployment process that it will never be possible to achieve Business Excellence. The paper has been divided...... Leadership System consists of two elements which we refer to as Core Value and Competence subsystems. The second section of this paper compares the conclusions of this selective analysis with the contents of a training package for leadership and human motivation that has been developed and deployed in both...

  1. Hippocampal gene expression analysis using the ORESTES methodology shows that homer 1a mRNA is upregulated in the acute period of the pilocarpine epilepsy model.

    Science.gov (United States)

    Avedissian, Marcelo; Longo, Beatriz M; Jaqueta, Carolina B; Schnabel, Beatriz; Paiva, Paulo B; Mello, Luiz Eugênio A M; Briones, Marcelo R S

    2007-01-01

    In the study of temporal lobe epilepsy (TLE) the characterization of genes expressed in the hippocampus is of central importance for understanding their roles in epileptogenic mechanisms. Although several large-scale studies on TLE gene expression have been reported, precise assignment of individual genes associated with this syndrome is still debatable. Here we investigated differentially expressed genes by comparison of mRNAs from normal and epileptic rat hippocampus in the pilocarpine model of epilepsy. For this we used a powerful EST sequencing methodology, ORESTES (Open Reading frame Expressed Sequence Tags), which generates sequence datasets enriched for mRNAs open reading frames (ORFs) rather than simple 5' and 3' ends of mRNAs. Analysis of our sequences shows that ORESTES readily enables the identification of epilepsy associated ORFs. PFAM analysis of protein motifs present in our ORESTES epilepsy database revealed diverse important protein family domains, such as cytoskeletal, cell signaling and protein kinase domains, which could be involved in processes underlying epileptogenesis. More importantly, we show that the expression of homer 1a, known to be coupled to mGluR and NMDA synaptic transmission, is associated with pilocarpine induced status epilepticus (SE). The combined use of the pilocarpine model of epilepsy with the ORESTES technique can significantly contribute to the identification of specific genes and proteins related to TLE. This is the first study applying a large-scale method for rapid shotgun sequencing directed to ORFs in epilepsy research.

  2. Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease.

    Science.gov (United States)

    Grealish, Shane; Diguet, Elsa; Kirkeby, Agnete; Mattsson, Bengt; Heuer, Andreas; Bramoulle, Yann; Van Camp, Nadja; Perrier, Anselme L; Hantraye, Philippe; Björklund, Anders; Parmar, Malin

    2014-11-06

    Considerable progress has been made in generating fully functional and transplantable dopamine neurons from human embryonic stem cells (hESCs). Before these cells can be used for cell replacement therapy in Parkinson's disease (PD), it is important to verify their functional properties and efficacy in animal models. Here we provide a comprehensive preclinical assessment of hESC-derived midbrain dopamine neurons in a rat model of PD. We show long-term survival and functionality using clinically relevant MRI and PET imaging techniques and demonstrate efficacy in restoration of motor function with a potency comparable to that seen with human fetal dopamine neurons. Furthermore, we show that hESC-derived dopamine neurons can project sufficiently long distances for use in humans, fully regenerate midbrain-to-forebrain projections, and innervate correct target structures. This provides strong preclinical support for clinical translation of hESC-derived dopamine neurons using approaches similar to those established with fetal cells for the treatment of Parkinson's disease. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  3. Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson’s Disease

    Science.gov (United States)

    Grealish, Shane; Diguet, Elsa; Kirkeby, Agnete; Mattsson, Bengt; Heuer, Andreas; Bramoulle, Yann; Van Camp, Nadja; Perrier, Anselme L.; Hantraye, Philippe; Björklund, Anders; Parmar, Malin

    2014-01-01

    Summary Considerable progress has been made in generating fully functional and transplantable dopamine neurons from human embryonic stem cells (hESCs). Before these cells can be used for cell replacement therapy in Parkinson’s disease (PD), it is important to verify their functional properties and efficacy in animal models. Here we provide a comprehensive preclinical assessment of hESC-derived midbrain dopamine neurons in a rat model of PD. We show long-term survival and functionality using clinically relevant MRI and PET imaging techniques and demonstrate efficacy in restoration of motor function with a potency comparable to that seen with human fetal dopamine neurons. Furthermore, we show that hESC-derived dopamine neurons can project sufficiently long distances for use in humans, fully regenerate midbrain-to-forebrain projections, and innervate correct target structures. This provides strong preclinical support for clinical translation of hESC-derived dopamine neurons using approaches similar to those established with fetal cells for the treatment of Parkinson’s disease. PMID:25517469

  4. Climate envelope modeling and dispersal simulations show little risk of range extension of the Shipworm, Teredo navalis (L., in the Baltic sea.

    Directory of Open Access Journals (Sweden)

    Christin Appelqvist

    Full Text Available The shipworm, Teredo navalis, is absent from most of the Baltic Sea. In the last 20 years, increased frequency of T. navalis has been reported along the southern Baltic Sea coasts of Denmark, Germany, and Sweden, indicating possible range-extensions into previously unoccupied areas. We evaluated the effects of historical and projected near-future changes in salinity, temperature, and oxygen on the risk of spread of T. navalis in the Baltic. Specifically, we developed a simple, GIS-based, mechanistic climate envelope model to predict the spatial distribution of favourable conditions for adult reproduction and larval metamorphosis of T. navalis, based on published environmental tolerances to these factors. In addition, we used a high-resolution three-dimensional hydrographic model to simulate the probability of spread of T. navalis larvae within the study area. Climate envelope modeling showed that projected near-future climate change is not likely to change the overall distribution of T. navalis in the region, but will prolong the breeding season and increase the risk of shipworm establishment at the margins of the current range. Dispersal simulations indicated that the majority of larvae were philopatric, but those that spread over a wider area typically spread to areas unfavourable for their survival. Overall, therefore, we found no substantive evidence for climate-change related shifts in the distribution of T. navalis in the Baltic Sea, and no evidence for increased risk of spread in the near-future.

  5. The Pitfalls of Testing in the Quest of Excellence.

    Science.gov (United States)

    Goodwin, Coleen R.

    This document presents five scenarios, each referring to a means of assessing learning. These examples are then used to discuss pitfalls faced when tests are used to assess learning, and the conclusion is reached that testing should play a supportive role only, not a major role in the quest for excellence. Effective schools research shows that…

  6. Synthesis, Modelling, and Anticonvulsant Studies of New Quinazolines Showing Three Highly Active Compounds with Low Toxicity and High Affinity to the GABA-A Receptor.

    Science.gov (United States)

    Zayed, Mohamed F; Ihmaid, Saleh K; Ahmed, Hany E A; El-Adl, Khaled; Asiri, Ahmed M; Omar, Abdelsattar M

    2017-01-24

    Some novel fluorinated quinazolines (5a-j) were designed and synthesized to be evaluated for their anticonvulsant activity and their neurotoxicity. Structures of all newly synthesized compounds were confirmed by their infrared (IR), mass spectrometry (MS) spectra, ¹H nuclear magnetic resonance (NMR), (13)C-NMR, and elemental analysis (CHN). The anticonvulsant activity was evaluated by a subcutaneous pentylenetetrazole (scPTZ) test and maximal electroshock (MES)-induced seizure test, while neurotoxicity was evaluated by a rotorod test. The molecular docking was performed for all newly-synthesized compounds to assess their binding affinities to the GABA-A receptor in order to rationalize their anticonvulsant activities in a qualitative way. The data obtained from the molecular modeling was correlated with that obtained from the biological screening. These data showed considerable anticonvulsant activity for all newly-synthesized compounds. Compounds 5b, 5c, and 5d showed the highest binding affinities toward the GABA-A receptor, along with the highest anticonvulsant activities in experimental mice. These compounds also showed low neurotoxicity and low toxicity in the median lethal dose test compared to the reference drugs. A GABA enzymatic assay was performed for these highly active compounds to confirm the obtained results and explain the possible mechanism for anticonvulsant action. The most active compounds might be used as leads for future modification and optimization.

  7. Showing Value (Editorial

    Directory of Open Access Journals (Sweden)

    Denise Koufogiannakis

    2009-06-01

    librarians on student achievement. Todd notes, “If we do not show value, we will not have a future. Evidence-based practice is not about the survival of school librarians, it’s about the survival of our students” (40. In this issue we feature school libraries and their connection to evidence based practice. Former Editor-in-Chief, Lindsay Glynn, began putting the wheels in motion for this feature almost a year ago. She invited Carol Gordon and Ross Todd to act as guest editors of the section, drawing upon their contacts and previous work in this field. The result is an issue with five feature articles exploring different aspects of the connection between school libraries and evidence based practice, from the theoretical to the practical. In addition, there is a thought-provoking Commentary by David Loertscher, asking whether we need the evolutionary model of evidence based practice, or something more revolutionary!In addition to the Feature section, we have a well-rounded issue with articles on the topics of library human resources, and the development of a scholars’ portal. As well, there are a record 10 evidence summaries and our educational EBL101 column. I hope there is something for everyone in this issue of EBLIP – enjoy, and see you soon in Stockholm!

  8. Creating cultures of excellence: Strategies and outcomes

    Directory of Open Access Journals (Sweden)

    Michael Mintrom

    2014-12-01

    Full Text Available Research findings on effective support for learning, the development of expertise, and the psychology of success suggest that the pursuit of excellence is teachable. Within the emerging field of research and practice termed “the scholarship of teaching and learning,” considerable effort has been made to document the practices of teachers who, by various measures, have been deemed excellent. In contrast, no effort has been made to codify how students can be trained to self-consciously build behaviors that generate excellent outcomes. This article reports on a multi-year effort to create cultures of excellence among cohorts of graduate students. A statistical analysis of subsequent student performance on a significant, related task indicates that explicitly promoting a culture of excellence among course participants can have a positive and sustained impact on their individual practices. Comments from subsequent student reflections further support this claim. The teaching strategies reported here could be refined, replicated, and reinvented to good effect across higher education. They are also of special relevance to those delivering professional development training to early- and mid-career professionals.

  9. Combined MRI and 31P-MRS Investigations of the ACTA1(H40Y) Mouse Model of Nemaline Myopathy Show Impaired Muscle Function and Altered Energy Metabolism

    Science.gov (United States)

    Gineste, Charlotte; Le Fur, Yann; Vilmen, Christophe; Le Troter, Arnaud; Pecchi, Emilie; Cozzone, Patrick J.; Hardeman, Edna C.; Bendahan, David; Gondin, Julien

    2013-01-01

    Nemaline myopathy (NM) is the most common disease entity among non-dystrophic skeletal muscle congenital diseases. Mutations in the skeletal muscle α-actin gene (ACTA1) account for ∼25% of all NM cases and are the most frequent cause of severe forms of NM. So far, the mechanisms underlying muscle weakness in NM patients remain unclear. Additionally, recent Magnetic Resonance Imaging (MRI) studies reported a progressive fatty infiltration of skeletal muscle with a specific muscle involvement in patients with ACTA1 mutations. We investigated strictly noninvasively the gastrocnemius muscle function of a mouse model carrying a mutation in the ACTA1 gene (H40Y). Skeletal muscle anatomy (hindlimb muscles and fat volumes) and energy metabolism were studied using MRI and 31Phosphorus magnetic resonance spectroscopy. Skeletal muscle contractile performance was investigated while applying a force-frequency protocol (from 1–150 Hz) and a fatigue protocol (80 stimuli at 40 Hz). H40Y mice showed a reduction of both absolute (−40%) and specific (−25%) maximal force production as compared to controls. Interestingly, muscle weakness was associated with an improved resistance to fatigue (+40%) and an increased energy cost. On the contrary, the force frequency relationship was not modified in H40Y mice and the extent of fatty infiltration was minor and not different from the WT group. We concluded that the H40Y mouse model does not reproduce human MRI findings but shows a severe muscle weakness which might be related to an alteration of intrinsic muscular properties. The increased energy cost in H40Y mice might be related to either an impaired mitochondrial function or an alteration at the cross-bridges level. Overall, we provided a unique set of anatomic, metabolic and functional biomarkers that might be relevant for monitoring the progression of NM disease but also for assessing the efficacy of potential therapeutic interventions at a preclinical level. PMID:23613869

  10. A water-soluble extract from Cucurbita moschata shows anti-obesity effects by controlling lipid metabolism in a high fat diet-induced obesity mouse model.

    Science.gov (United States)

    Choi, Hyounjeong; Eo, Haekwan; Park, Kyoungcheol; Jin, Mirim; Park, Eun-Jin; Kim, Seon-Hee; Park, Jeong Euy; Kim, Sunyoung

    2007-08-01

    During the screening of a variety of plant sources for their anti-obesity activity, it was found that a water-soluble extract, named PG105, prepared from stem parts of Cucurbita moschata, contains potent anti-obesity activities in a high fat diet-induced obesity mouse model. In this animal model, increases in body weight and fat storage were suppressed by 8-week oral administration of PG105 at 500 mg/kg, while the overall amount of food intake was not affected. Furthermore, PG105 protected the development of fatty liver and increased the hepatic beta-oxidation activity. Results from blood analysis showed that the levels of triglyceride and cholesterol were significantly lowered by PG105 administration, and also that the level of leptin was reduced, while that of adiponectin was increased. To understand the underlying mechanism at the molecular level, the effects of PG105 were examined on the expression of the genes involved in lipid metabolism by Northern blot analysis. In the liver of PG105-treated mice, the mRNA level of lipogenic genes such as SREBP-1c and SCD-1 was decreased, while that of lipolytic genes such as PPARalpha, ACO-1, CPT-1, and UCP-2 was modestly increased. Our data suggest that PG105 may have great potential as a novel anti-obesity agent in that both inhibition of lipid synthesis and acceleration of fatty acid breakdown are induced by this reagent.

  11. Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington’s disease

    Science.gov (United States)

    Zeng, Yixuan; Guo, Wenyuan; Xu, Guangqing; Wang, Qinmei; Feng, Luyang; Long, Simei; Liang, Fengyin; Huang, Yi; Lu, Xilin; Li, Shichang; Zhou, Jiebin; Burgunder, Jean-Marc; Pang, Jiyan; Pei, Zhong

    2016-01-01

    Huntington’s disease is an autosomal-dominant neurodegenerative disorder, with chorea as the most prominent manifestation. The disease is caused by abnormal expansion of CAG codon repeats in the IT15 gene, which leads to the expression of a glutamine-rich protein named mutant Huntingtin (Htt). Because of its devastating disease burden and lack of valid treatment, development of more effective therapeutics for Huntington’s disease is urgently required. Xyloketal B, a natural product from mangrove fungus, has shown protective effects against toxicity in other neurodegenerative disease models such as Parkinson’s and Alzheimer’s diseases. To identify potential neuroprotective molecules for Huntington’s disease, six derivatives of xyloketal B were screened in a Caenorhabditis elegans Huntington’s disease model; all six compounds showed a protective effect. Molecular docking studies indicated that compound 1 could bind to residues GLN369 and GLN393 of the mutant Htt protein, forming a stable trimeric complex that can prevent the formation of mutant Htt aggregates. Taken together, we conclude that xyloketal derivatives could be novel drug candidates for treating Huntington’s disease. Molecular target analysis is a good method to simulate the interaction between proteins and drug compounds. Further, protective candidate drugs could be designed in future using the guidance of molecular docking results. PMID:27110099

  12. Polysaccharides from the Medicinal Mushroom Cordyceps taii Show Antioxidant and Immunoenhancing Activities in a D-Galactose-Induced Aging Mouse Model

    Directory of Open Access Journals (Sweden)

    Jian-Hui Xiao

    2012-01-01

    Full Text Available Cordyceps taii, an edible medicinal mushroom native to south China, is recognized as an unparalleled resource of healthy foods and drug discovery. In the present study, the antioxidant pharmacological properties of C. taii were systematically investigated. In vitro assays revealed the scavenging activities of the aqueous extract and polysaccharides of C. taii against various free radicals, that is, 1,1-diphenyl-2-picrylhydrazyl radical, hydroxyl radical, and superoxide anion radical. The EC50 values for superoxide anion-free radical ranged from 2.04 mg/mL to 2.49 mg/mL, which was at least 2.6-fold stronger than that of antioxidant thiourea. The polysaccharides also significantly enhanced the antioxidant enzyme activities (superoxide dismutase, catalase, and glutathione peroxidase and markedly decreased the malondialdehyde production of lipid peroxidation in a D-galactose-induced aging mouse model. Interestingly, the immune function of the administration group was significantly boosted compared with the D-galactose-induced aging model group. Therefore, the C. taii polysaccharides possessed potent antioxidant activity closely associated with immune function enhancement and free radical scavenging. These findings suggest that the polysaccharides are a promising source of natural antioxidants and antiaging drugs. Consequently, a preliminary chemical investigation was performed using gas chromatography-mass spectroscopy and revealed that the polysaccharides studied were mainly composed of glucose, mannose, and galactose. Fourier-transform infrared spectra also showed characteristic polysaccharide absorption bands.

  13. Polysaccharides from the Medicinal Mushroom Cordyceps taii Show Antioxidant and Immunoenhancing Activities in a D-Galactose-Induced Aging Mouse Model

    Science.gov (United States)

    Xiao, Jian-Hui; Xiao, Dai-Min; Chen, Dai-Xiong; Xiao, Yu; Liang, Zong-Qi; Zhong, Jian-Jiang

    2012-01-01

    Cordyceps taii, an edible medicinal mushroom native to south China, is recognized as an unparalleled resource of healthy foods and drug discovery. In the present study, the antioxidant pharmacological properties of C. taii were systematically investigated. In vitro assays revealed the scavenging activities of the aqueous extract and polysaccharides of C. taii against various free radicals, that is, 1,1-diphenyl-2-picrylhydrazyl radical, hydroxyl radical, and superoxide anion radical. The EC50 values for superoxide anion-free radical ranged from 2.04 mg/mL to 2.49 mg/mL, which was at least 2.6-fold stronger than that of antioxidant thiourea. The polysaccharides also significantly enhanced the antioxidant enzyme activities (superoxide dismutase, catalase, and glutathione peroxidase) and markedly decreased the malondialdehyde production of lipid peroxidation in a D-galactose-induced aging mouse model. Interestingly, the immune function of the administration group was significantly boosted compared with the D-galactose-induced aging model group. Therefore, the C. taii polysaccharides possessed potent antioxidant activity closely associated with immune function enhancement and free radical scavenging. These findings suggest that the polysaccharides are a promising source of natural antioxidants and antiaging drugs. Consequently, a preliminary chemical investigation was performed using gas chromatography-mass spectroscopy and revealed that the polysaccharides studied were mainly composed of glucose, mannose, and galactose. Fourier-transform infrared spectra also showed characteristic polysaccharide absorption bands. PMID:22536281

  14. Show them the money? The role of pay, managerial need support, and justice in a self-determination theory model of intrinsic work motivation.

    Science.gov (United States)

    Olafsen, Anja H; Halvari, Hallgeir; Forest, Jacques; Deci, Edward L

    2015-08-01

    The link between money and motivation has been a debated topic for decades, especially in work organizations. However, field studies investigating the amount of pay in relation to employee motivation is lacking and there have been calls for empirical studies addressing compensation systems and motivation in the work domain. The purpose of this study was to examine outcomes associated with the amount of pay, and perceived distributive and procedural justice regarding pay in relation to those for perceived managerial need support. Participants were 166 bank employees who also reported on their basic psychological need satisfaction and intrinsic work motivation. SEM-analyses tested a self-determination theory (SDT) model, with satisfaction of the competence and autonomy needs as an intervening variable. The primary findings were that amount of pay and employees' perceived distributive justice regarding their pay were unrelated to employees' need satisfaction and intrinsic work motivation, but procedural justice regarding pay did affect these variables. However, managerial need support was the most important factor for promoting need satisfaction and intrinsic work motivation both directly, indirectly, and as a moderator in the model. Hence, the results of the present organizational field study support earlier laboratory experiments within the SDT framework showing that monetary rewards did not enhance intrinsic motivation. This seems to have profound implications for organizations concerned about motivating their employees.

  15. Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington's disease.

    Science.gov (United States)

    Zeng, Yixuan; Guo, Wenyuan; Xu, Guangqing; Wang, Qinmei; Feng, Luyang; Long, Simei; Liang, Fengyin; Huang, Yi; Lu, Xilin; Li, Shichang; Zhou, Jiebin; Burgunder, Jean-Marc; Pang, Jiyan; Pei, Zhong

    2016-01-01

    Huntington's disease is an autosomal-dominant neurodegenerative disorder, with chorea as the most prominent manifestation. The disease is caused by abnormal expansion of CAG codon repeats in the IT15 gene, which leads to the expression of a glutamine-rich protein named mutant Huntingtin (Htt). Because of its devastating disease burden and lack of valid treatment, development of more effective therapeutics for Huntington's disease is urgently required. Xyloketal B, a natural product from mangrove fungus, has shown protective effects against toxicity in other neurodegenerative disease models such as Parkinson's and Alzheimer's diseases. To identify potential neuroprotective molecules for Huntington's disease, six derivatives of xyloketal B were screened in a Caenorhabditis elegans Huntington's disease model; all six compounds showed a protective effect. Molecular docking studies indicated that compound 1 could bind to residues GLN369 and GLN393 of the mutant Htt protein, forming a stable trimeric complex that can prevent the formation of mutant Htt aggregates. Taken together, we conclude that xyloketal derivatives could be novel drug candidates for treating Huntington's disease. Molecular target analysis is a good method to simulate the interaction between proteins and drug compounds. Further, protective candidate drugs could be designed in future using the guidance of molecular docking results.

  16. Significant blockade of multiple receptor tyrosine kinases by MGCD516 (Sitravatinib), a novel small molecule inhibitor, shows potent anti-tumor activity in preclinical models of sarcoma.

    Science.gov (United States)

    Patwardhan, Parag P; Ivy, Kathryn S; Musi, Elgilda; de Stanchina, Elisa; Schwartz, Gary K

    2016-01-26

    Sarcomas are rare but highly aggressive mesenchymal tumors with a median survival of 10-18 months for metastatic disease. Mutation and/or overexpression of many receptor tyrosine kinases (RTKs) including c-Met, PDGFR, c-Kit and IGF1-R drive defective signaling pathways in sarcomas. MGCD516 (Sitravatinib) is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth. In the present study, we evaluated the efficacy of MGCD516 both in vitro and in mouse xenograft models in vivo. MGCD516 treatment resulted in significant blockade of phosphorylation of potential driver RTKs and induced potent anti-proliferative effects in vitro. Furthermore, MGCD516 treatment of tumor xenografts in vivo resulted in significant suppression of tumor growth. Efficacy of MGCD516 was superior to imatinib and crizotinib, two other well-studied multi-kinase inhibitors with overlapping target specificities, both in vitro and in vivo. This is the first report describing MGCD516 as a potent multi-kinase inhibitor in different models of sarcoma, superior to imatinib and crizotinib. Results from this study showing blockade of multiple driver signaling pathways provides a rationale for further clinical development of MGCD516 for the treatment of patients with soft-tissue sarcoma.

  17. The BACHD Rat Model of Huntington Disease Shows Signs of Fronto-Striatal Dysfunction in Two Operant Conditioning Tests of Short-Term Memory

    Science.gov (United States)

    Clemensson, Laura Emily; Riess, Olaf; Nguyen, Huu Phuc

    2017-01-01

    The BACHD rat is a recently developed transgenic animal model of Huntington disease, a progressive neurodegenerative disorder characterized by extensive loss of striatal neurons. Cognitive impairments are common among patients, and characterization of similar deficits in animal models of the disease is therefore of interest. The present study assessed the BACHD rats' performance in the delayed alternation and the delayed non-matching to position test, two Skinner box-based tests of short-term memory function. The transgenic rats showed impaired performance in both tests, indicating general problems with handling basic aspects of the tests, while short-term memory appeared to be intact. Similar phenotypes have been found in rats with fronto-striatal lesions, suggesting that Huntington disease-related neuropathology might be present in the BACHD rats. Further analyses indicated that the performance deficit in the delayed alternation test might be due to impaired inhibitory control, which has also been implicated in Huntington disease patients. The study ultimately suggests that the BACHD rats might suffer from neuropathology and cognitive impairments reminiscent of those of Huntington disease patients. PMID:28045968

  18. The BACHD Rat Model of Huntington Disease Shows Signs of Fronto-Striatal Dysfunction in Two Operant Conditioning Tests of Short-Term Memory.

    Science.gov (United States)

    Clemensson, Erik Karl Håkan; Clemensson, Laura Emily; Riess, Olaf; Nguyen, Huu Phuc

    2017-01-01

    The BACHD rat is a recently developed transgenic animal model of Huntington disease, a progressive neurodegenerative disorder characterized by extensive loss of striatal neurons. Cognitive impairments are common among patients, and characterization of similar deficits in animal models of the disease is therefore of interest. The present study assessed the BACHD rats' performance in the delayed alternation and the delayed non-matching to position test, two Skinner box-based tests of short-term memory function. The transgenic rats showed impaired performance in both tests, indicating general problems with handling basic aspects of the tests, while short-term memory appeared to be intact. Similar phenotypes have been found in rats with fronto-striatal lesions, suggesting that Huntington disease-related neuropathology might be present in the BACHD rats. Further analyses indicated that the performance deficit in the delayed alternation test might be due to impaired inhibitory control, which has also been implicated in Huntington disease patients. The study ultimately suggests that the BACHD rats might suffer from neuropathology and cognitive impairments reminiscent of those of Huntington disease patients.

  19. Daily supplementation of D-ribose shows no therapeutic benefits in the MHC-I transgenic mouse model of inflammatory myositis.

    Directory of Open Access Journals (Sweden)

    William Coley

    Full Text Available BACKGROUND: Current treatments for idiopathic inflammatory myopathies (collectively called myositis focus on the suppression of an autoimmune inflammatory response within the skeletal muscle. However, it has been observed that there is a poor correlation between the successful suppression of muscle inflammation and an improvement in muscle function. Some evidence in the literature suggests that metabolic abnormalities in the skeletal muscle underlie the weakness that continues despite successful immunosuppression. We have previously shown that decreased expression of a purine nucleotide cycle enzyme, adenosine monophosphate deaminase (AMPD1, leads to muscle weakness in a mouse model of myositis and may provide a mechanistic basis for muscle weakness. One of the downstream metabolites of this pathway, D-ribose, has been reported to alleviate symptoms of myalgia in patients with a congenital loss of AMPD1. Therefore, we hypothesized that supplementing exogenous D-ribose would improve muscle function in the mouse model of myositis. We treated normal and myositis mice with daily doses of D-ribose (4 mg/kg over a 6-week time period and assessed its effects using a battery of behavioral, functional, histological and molecular measures. RESULTS: Treatment with D-ribose was found to have no statistically significant effects on body weight, grip strength, open field behavioral activity, maximal and specific forces of EDL, soleus muscles, or histological features. Histological and gene expression analysis indicated that muscle tissues remained inflamed despite treatment. Gene expression analysis also suggested that low levels of the ribokinase enzyme in the skeletal muscle might prevent skeletal muscle tissue from effectively utilizing D-ribose. CONCLUSIONS: Treatment with daily oral doses of D-ribose showed no significant effect on either disease progression or muscle function in the mouse model of myositis.

  20. The Great Cometary Show

    Science.gov (United States)

    2007-01-01

    its high spatial and spectral resolution, it was possible to zoom into the very heart of this very massive star. In this innermost region, the observations are dominated by the extremely dense stellar wind that totally obscures the underlying central star. The AMBER observations show that this dense stellar wind is not spherically symmetric, but exhibits a clearly elongated structure. Overall, the AMBER observations confirm that the extremely high mass loss of Eta Carinae's massive central star is non-spherical and much stronger along the poles than in the equatorial plane. This is in agreement with theoretical models that predict such an enhanced polar mass-loss in the case of rapidly rotating stars. ESO PR Photo 06c/07 ESO PR Photo 06c/07 RS Ophiuchi in Outburst Several papers from this special feature focus on the later stages in a star's life. One looks at the binary system Gamma 2 Velorum, which contains the closest example of a star known as a Wolf-Rayet. A single AMBER observation allowed the astronomers to separate the spectra of the two components, offering new insights in the modeling of Wolf-Rayet stars, but made it also possible to measure the separation between the two stars. This led to a new determination of the distance of the system, showing that previous estimates were incorrect. The observations also revealed information on the region where the winds from the two stars collide. The famous binary system RS Ophiuchi, an example of a recurrent nova, was observed just 5 days after it was discovered to be in outburst on 12 February 2006, an event that has been expected for 21 years. AMBER was able to detect the extension of the expanding nova emission. These observations show a complex geometry and kinematics, far from the simple interpretation of a spherical fireball in extension. AMBER has detected a high velocity jet probably perpendicular to the orbital plane of the binary system, and allowed a precise and careful study of the wind and the shockwave

  1. Predictors of excellent response to lithium

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Hellmund, Gunnar; Andersen, Per Kragh

    2011-01-01

    The aim of this study was to identify sociodemographic and clinical predictors of excellent response, that is, 'cure' of future affective episodes, to lithium in monotherapy. We used nationwide registers to identify all patients with a diagnosis of bipolar disorder in psychiatric hospital settings...... who were prescribed lithium from 1995 to 2006 in Denmark (N=3762). Excellent lithium responders were defined as patients who after a stabilization lithium start-up period of 6 months, continued lithium in monotherapy without getting hospitalized. The rate of excellent response to lithium...... in monotherapy was 8.9% [95% confidence interval (CI): 7.9-9.9] at 5-year follow-up and 5.4% (95% CI: 4.4-6.3) at 10-year follow-up. The rate of nonresponse to lithium monotherapy was significantly increased for female patients [hazards ratio (HR)=1.12, 95% CI: 1.04-1.21) and for patients with a depressive index...

  2. Auto Draw from Excel Input Files

    Science.gov (United States)

    Strauss, Karl F.; Goullioud, Renaud; Cox, Brian; Grimes, James M.

    2011-01-01

    The design process often involves the use of Excel files during project development. To facilitate communications of the information in the Excel files, drawings are often generated. During the design process, the Excel files are updated often to reflect new input. The problem is that the drawings often lag the updates, often leading to confusion of the current state of the design. The use of this program allows visualization of complex data in a format that is more easily understandable than pages of numbers. Because the graphical output can be updated automatically, the manual labor of diagram drawing can be eliminated. The more frequent update of system diagrams can reduce confusion and reduce errors and is likely to uncover symmetric problems earlier in the design cycle, thus reducing rework and redesign.

  3. Microsoft Excel: a tool for research.

    Directory of Open Access Journals (Sweden)

    Luis Orlando Pérez González

    2006-12-01

    Full Text Available Frequently, our professionals in their research activity, lack of some knowledge and skills to deal with strong as well as complex statistical systems like SPSS; even these last are not available occasionally, and they have to look for other partners help. Besides, sometimes Microsoft Excel is undervaluated as a tool for research. This software could be of much help for this aim. Excel is basically an electronic calculation sheet, but it is much more, it is a very good option to solve most statistical needs in our researches.

  4. Excellence in the Surface Coast Guard.

    Science.gov (United States)

    1984-12-01

    up to a point of excellence." One captain described the influence structure o the different people as a pyramid . The CO is the top, followed by the... pyramid or in this case, the deteriation of a unit’s ability to complete its missions. "Everyone must make a contribution to the excellence of a un.i.t...units so as to satisfy the hierarchy of needs as described by Maslow . The captains of both cutters we visited are firm believers in McGregor’s Theory

  5. Investigaiting the cultivating model of“excellent engineer program”on the environmental enginnering%环境工程专业“卓越工程师计划”培养模式探讨

    Institute of Scientific and Technical Information of China (English)

    张瑾; 刘洁雪

    2016-01-01

    “卓越工程师计划”是基于传统教学模式基础上的工程实践教学改革,更注重大学生工程素质和能力的培养。以学校环境工程专业为改革对象,全面分析与探讨实施环境工程专业卓越工程师计划的必然性、基础与措施。通过改革与完善现有的课程教学体系与校内外多维实践教学基地的建立,实现了学校培养工程应用型人才的目的,满足了国家培养人才的需求。研究结果对于卓越工程计划及在其它专业方面的教学改革,具有一定的参考价值。%The"excellent engineer program"is to teaching reform of engineering practice based on the traditional theory tea-ching, which puts more emphasis on the training of engineering quality and ability. Selecting the major of envrionmental en-ginneering of our school as research object, we systimatically analyzed its actual situation of the practical teaching require-ments and problems, then investigated the inevitability, basis and measures of application of"excellent engineer program"into the major of environmental enginneering. Based on the reform and compensation of the present teaching class systems and con-struction of practical teaching foundation in various fields, we realized the cultivation object of our school and met the requi-rements of national cultivation talents. The obtained results provides a case for the study of"Excellent engineer program".

  6. Long-term field data and climate-habitat models show that orangutan persistence depends on effective forest management and greenhouse gas mitigation.

    Directory of Open Access Journals (Sweden)

    Stephen D Gregory

    Full Text Available BACKGROUND: Southeast Asian deforestation rates are among the world's highest and threaten to drive many forest-dependent species to extinction. Climate change is expected to interact with deforestation to amplify this risk. Here we examine whether regional incentives for sustainable forest management will be effective in improving threatened mammal conservation, in isolation and when combined with global climate change mitigation. METHODOLOGY/PRINCIPAL FINDINGS: Using a long time-series of orangutan nest counts for Sabah (2000-10, Malaysian Borneo, we evaluated the effect of sustainable forest management and climate change scenarios, and their interaction, on orangutan spatial abundance patterns. By linking dynamic land-cover and downscaled global climate model projections, we determine the relative influence of these factors on orangutan spatial abundance and use the resulting statistical models to identify habitat crucial for their long-term conservation. We show that land-cover change the degradation of primary forest had the greatest influence on orangutan population size. Anticipated climate change was predicted to cause reductions in abundance in currently occupied populations due to decreased habitat suitability, but also to promote population growth in western Sabah by increasing the suitability of presently unoccupied regions. CONCLUSIONS/SIGNIFICANCE: We find strong quantitative support for the Sabah government's proposal to implement sustainable forest management in all its forest reserves during the current decade; failure to do so could result in a 40 to 80 per cent regional decline in orangutan abundance by 2100. The Sabah orangutan is just one (albeit iconic example of a forest-dependent species that stands to benefit from sustainable forest management, which promotes conservation of existing forests.

  7. Long-Term Field Data and Climate-Habitat Models Show That Orangutan Persistence Depends on Effective Forest Management and Greenhouse Gas Mitigation

    Science.gov (United States)

    Gregory, Stephen D.; Brook, Barry W.; Goossens, Benoît; Ancrenaz, Marc; Alfred, Raymond; Ambu, Laurentius N.; Fordham, Damien A.

    2012-01-01

    Background Southeast Asian deforestation rates are among the world’s highest and threaten to drive many forest-dependent species to extinction. Climate change is expected to interact with deforestation to amplify this risk. Here we examine whether regional incentives for sustainable forest management will be effective in improving threatened mammal conservation, in isolation and when combined with global climate change mitigation. Methodology/Principal Findings Using a long time-series of orangutan nest counts for Sabah (2000–10), Malaysian Borneo, we evaluated the effect of sustainable forest management and climate change scenarios, and their interaction, on orangutan spatial abundance patterns. By linking dynamic land-cover and downscaled global climate model projections, we determine the relative influence of these factors on orangutan spatial abundance and use the resulting statistical models to identify habitat crucial for their long-term conservation. We show that land-cover change the degradation of primary forest had the greatest influence on orangutan population size. Anticipated climate change was predicted to cause reductions in abundance in currently occupied populations due to decreased habitat suitability, but also to promote population growth in western Sabah by increasing the suitability of presently unoccupied regions. Conclusions/Significance We find strong quantitative support for the Sabah government’s proposal to implement sustainable forest management in all its forest reserves during the current decade; failure to do so could result in a 40 to 80 per cent regional decline in orangutan abundance by 2100. The Sabah orangutan is just one (albeit iconic) example of a forest-dependent species that stands to benefit from sustainable forest management, which promotes conservation of existing forests. PMID:22970145

  8. Development of a novel pink-eyed dilution mouse model showing progressive darkening of the eyes and coat hair with aging.

    Science.gov (United States)

    Ishikawa, Akira; Sugiyama, Makoto; Hondo, Eiichi; Kinoshita, Keiji; Yamagishi, Yuki

    2015-01-01

    Oca2(p-cas) (oculocutaneous albinism II; pink-eyed dilution castaneus) is a coat color mutant gene on mouse chromosome 7 that arose spontaneously in wild Mus musculus castaneus mice. Mice homozygous for Oca2(p-cas) usually exhibit pink eyes and gray coat hair on the non-agouti genetic background, and this ordinary phenotype remains unchanged throughout life. During breeding of a mixed strain carrying this gene on the C57BL/6J background, we discovered a novel spontaneous mutation that causes darkening of the eyes and coat hair with aging. In this study, we developed a novel mouse model showing this unique phenotype. Gross observations revealed that the pink eyes and gray coat hair of the novel mutant young mice became progressively darker in color by approximately 3 months after birth. Light and transmission-electron microscopic observations revealed a marked increase in melanin pigmentation of coat hair shafts and choroid of the eye in the novel mice compared to that in the ordinary mice. Sequence analysis of Oca2(p-cas) revealed a 4.1-kb deletion involving exons 15 and 16 of its wild-type gene. However, there was no sequence difference between the two types of mutant mice. Mating experiments suggested that the novel mutant phenotype was not inherited in a simple fashion, due to incomplete penetrance. The novel spontaneous mutant mouse is the first example of progressive hair darkening animals and is an essential animal model for understanding of the regulation mechanisms of melanin biosynthesis with aging.

  9. Lineær programmering med Excel

    DEFF Research Database (Denmark)

    Lynggaard, Peter

    Publikationen giver en introduktion til faget "Lineær programmering". Formulering og løsning bygger på, at modellerne opstilles og løses i et Excel-regneark. Fremgangsmåden er forklaret trin for trin, således at hæftet kan bruges som selvstudiemateriale. Indholdsfortegnelse Generelt om styring og...

  10. University employees recognized for communications excellence

    OpenAIRE

    Greiner, Lori A.

    2007-01-01

    Eight employees in the Virginia Tech Office of University Relations and the College of Agriculture and Life Sciences received awards at the Association for Communications Excellence (ACE) conference. The 2007 ACE International Conference was held in Albuquerque, NM on June 16-19.

  11. Teaching excellence: what great teachers teach us.

    Science.gov (United States)

    Johnson-Farmer, Barbara; Frenn, Marilyn

    2009-01-01

    Given the shortage of nurse educators, we sought to better understand teaching excellence because it is crucial for developing the next generation of nurses. A grounded theory approach was used. The sample included 17 respondents, thought to be excellent teachers, from universities across the United States. Consenting respondents were asked, "What do you do to bring nursing to life with your students?" Using line-by-line coding and the constant comparative method, five major themes emerged: (a) engagement, (b) relevance, (c) student centeredness, (d) facilitation of learning, and (e) dynamic process of becoming an excellent nursing educator. We found that the core category, engagement, included the faculty being (a) current and knowledgeable, (b) being clear in communication of objectives/outcomes, (c) being student centered, (d) being able to draw all students into active questioning and learning so that the process of discovery is enjoyable, and (e) using multiple strategies in teaching the content. The process of becoming an excellent teacher involved "change from 'instiller' to 'facilitator' and laid the foundation for continued development of my teaching self." Those beginning to teach or seeking to improve their teaching may find the results enlightening.

  12. Humour: An Excellent EFL Teaching Device.

    Science.gov (United States)

    Guindal, Albert Lopez

    Humor is an excellent teaching tool because, in addition to preventing classroom boredom and monotony, it introduces lateral aspects of language such as irony, sarcasm, mockery, elision, ellipsis, and euphemism. Humor in language can be approached interactively or structurally through a variety of activities. It can be used to expand vocabulary,…

  13. Introduction to 3D Graphics through Excel

    Science.gov (United States)

    Benacka, Jan

    2013-01-01

    The article presents a method of explaining the principles of 3D graphics through making a revolvable and sizable orthographic parallel projection of cuboid in Excel. No programming is used. The method was tried in fourteen 90 minute lessons with 181 participants, which were Informatics teachers, undergraduates of Applied Informatics and gymnasium…

  14. Evaluation of Principals; Leadership Excellence Achievement Plan.

    Science.gov (United States)

    Redfern, George B.; Hersey, Paul W.

    1981-01-01

    The Leadership Excellence Achievement Plan (LEAP) presented here is a way for principals to improve leadership ability with an emphasis on evaluation. It first recommends formulating a precise definition of the principal's job divided into three areas: technical competencies, administrative skills, and performance goals. Among the technical…

  15. Achieving Excellence: Mastery Learning in Legal Education.

    Science.gov (United States)

    Feinman, J. M.; Feldman, Marc

    1985-01-01

    Law schools should require excellence of all students, and mastery learning is a technique useful for structuring entire curricula or course segments to achieve high standards. A Rutgers course in contracts, torts, and legal research and writing developed to apply mastery learning strategies has proven successful. (MSE)

  16. Expanding Educational Excellence: The Power of Schools

    Science.gov (United States)

    Coleman, Mary Ruth; Winn, Donna-Marie; Harradine, Christine

    2012-01-01

    In this paper, the authors explore four major barriers to academic success that must be addressed, briefly describe two projects that have worked to address these barriers, and make recommendations for moving forward as they work to expand educational excellence for all students. They provide examples of the myriad ways in which schools have the…

  17. Curriculum for Excellence: "A Brilliant Idea, But…"

    Science.gov (United States)

    Priestley, Mark; Minty, Sarah

    2013-01-01

    Scotland's Curriculum for Excellence typifies many international trends in curricular policy, through its emphasis on generic skills and competencies, its focus on pedagogy and its apparent extension of autonomy to teachers as agents of change. Such curricula pose considerable challenges to school systems, where prevailing practices are often at…

  18. Spreading of Excellence in Serious Gaming

    NARCIS (Netherlands)

    Westera, Wim; Berta, Riccardo; Moreno-Ger, Pablo; Bellotti, Francesco; Nadolski, Rob; Padrón-Nápoles, Carmen Luisa; Boyle, Liz; Beligan, Daniel; Baalsrud Hauge, Jannicke

    2014-01-01

    Westera, W., Berta, R., Moreno-Ger, P., Bellotti, F., Nadolski, R., Padrón-Nápoles, C. L., Boyle, L., Beligan, D., & Baalsrud Hauge, J. (2013, December 12). Spreading of Excellence in Serious Gaming. Presentation on the GALA project review meeting. Luxembourg: European Commission.

  19. 76 FR 6774 - Equity and Excellence Commission

    Science.gov (United States)

    2011-02-08

    ... Equity and Excellence Commission AGENCY: Office for Civil Rights, Department of Education. ACTION: Notice... view this document, as well as all other documents of this Department published in the Federal Register...: Russlynn Ali, Assistant Secretary, Office for Civil Rights. BILLING CODE 4000-01-P...

  20. Spreading of Excellence in Serious Gaming

    NARCIS (Netherlands)

    Westera, Wim; Berta, Riccardo; Moreno-Ger, Pablo; Bellotti, Francesco; Nadolski, Rob; Padrón-Nápoles, Carmen Luisa; Boyle, Liz; Beligan, Daniel; Baalsrud Hauge, Jannicke

    2014-01-01

    Westera, W., Berta, R., Moreno-Ger, P., Bellotti, F., Nadolski, R., Padrón-Nápoles, C. L., Boyle, L., Beligan, D., & Baalsrud Hauge, J. (2013, December 12). Spreading of Excellence in Serious Gaming. Presentation on the GALA project review meeting. Luxembourg: European Commission.

  1. Exploring the Interactions of the Dietary Plant Flavonoids Fisetin and Naringenin with G-Quadruplex and Duplex DNA, Showing Contrasting Binding Behavior: Spectroscopic and Molecular Modeling Approaches.

    Science.gov (United States)

    Bhattacharjee, Snehasish; Chakraborty, Sandipan; Sengupta, Pradeep K; Bhowmik, Sudipta

    2016-09-01

    Guanine-rich sequences have the propensity to fold into a four-stranded DNA structure known as a G-quadruplex (G4). G4 forming sequences are abundant in the promoter region of several oncogenes and become a key target for anticancer drug binding. Here we have studied the interactions of two structurally similar dietary plant flavonoids fisetin and naringenin with G4 as well as double stranded (duplex) DNA by using different spectroscopic and modeling techniques. Our study demonstrates the differential binding ability of the two flavonoids with G4 and duplex DNA. Fisetin more strongly interacts with parallel G4 structure than duplex DNA, whereas naringenin shows stronger binding affinity to duplex rather than G4 DNA. Molecular docking results also corroborate our spectroscopic results, and it was found that both of the ligands are stacked externally in the G4 DNA structure. C-ring planarity of the flavonoid structure appears to be a crucial factor for preferential G4 DNA recognition of flavonoids. The goal of this study is to explore the critical effects of small differences in the structure of closely similar chemical classes of such small molecules (flavonoids) which lead to the contrasting binding properties with the two different forms of DNA. The resulting insights may be expected to facilitate the designing of the highly selective G4 DNA binders based on flavonoid scaffolds.

  2. Adjunctive treatment of brexpiprazole with fluoxetine shows a rapid antidepressant effect in social defeat stress model: Role of BDNF-TrkB signaling

    Science.gov (United States)

    Ma, Min; Ren, Qian; Yang, Chun; Zhang, Ji-chun; Yao, Wei; Dong, Chao; Ohgi, Yuta; Futamura, Takashi; Hashimoto, Kenji

    2016-01-01

    Addition of low doses of the atypical antipsychotic drug brexpiprazole with selective serotonin reuptake inhibitors (SSRIs) could promote antidepressant effect in patients with major depressive disorder although the precise mechanisms underlying the action of the combination are unknown. Combination of low dose of brexpiprazole (0.1 mg/kg) and SSRI fluoxetine (10 mg/kg) could promote a rapid antidepressant effect in social defeat stress model although brexpiprazole or fluoxetine alone did not show antidepressant effect. Furthermore, the combination significantly improved alterations in the brain-derived neurotrophic factor (BDNF) - TrkB signaling and dendritic spine density in the prefrontal cortex, hippocampus, and nucleus accumbens in the susceptible mice after social defeat stress. Interestingly, TrkB antagonist ANA-12 significantly blocked beneficial effects of combination of brexpiprazole and fluoxetine on depression-like phenotype. These results suggest that BDNF-TrkB signaling plays a role in the rapid antidepressant action of the combination of brexpiprazole and fluoxetine. PMID:27991542

  3. The Health Show

    OpenAIRE

    Swann, David

    2011-01-01

    Dr David Swann interviewed on The Health Show, Series 1, Episode 5, 2011 for BBC World about the award-winning 21st Century Nursing Bag. BBC World News reaches 241million people every week, available in 296 million homes, 1.8 million hotel rooms and has the highest average viewership on a weekday of any international news channel. The Health Show is a new 26-part series for BBC World News covering the most important news stories from around the world.

  4. SARNET: Severe accident research network of excellence

    Energy Technology Data Exchange (ETDEWEB)

    Albiol, T.; Van Dorsselaere, J. P. [IRSN, DPAM, F-13115 St Paul Les Durance (France); Chaumont, B. [IRSN, DSR, SAGR, F-92262 Fontenay Aux Roses (France); Haste, T. [Paul Scherrer Inst, NES, LTH, OVGA 312, CH-5232 Villigen (Switzerland); Journeau, Ch. [CEA Cadarache, DEN, STRI, LMA, F-13115 St Paul Les Durance (France); Meyer, L. [Forschungszentrum Karlsruhe, D-76021 Karlsruhe (Germany); Sehgal, Bal Raj [KTH, AlbaNova Univ Ctr, S-10691 Stockholm (Sweden); Schwinges, Bernd [Gesell Anlagen and Reaktorsicherheit GRS mbH, D-50667 Cologne (Germany); Beraha, D. [GRS mbH, Forschungsgelande, D-85748 Garching (Germany); Annunziato, A. [Commiss European Communities, JRC, IPSC, I-21020 Ispra, VA (Italy); Zeyen, R. [Commiss European Communities, JRC IE, IRSN DPAM DIR, F-13115 St Paul Les Durance (France)

    2010-07-01

    Fifty-one organisations network in SARNET (Severe Accident Research Network of Excellence) their research capacities in order to resolve the most important pending issues for enhancing, with regard to Severe Accidents (SA), the safety of existing and future Nuclear Power Plants (NPPs). This project. co-funded by the European Commission (EC) under the 6. Framework Programme, has been defined in order to optimise the use of the available means and to constitute sustainable research groups in the European Union. SARNET tackles the fragmentation that may exist between the different national R and D programmes, in defining common research programmes and developing common computer tools and methodologies for safety assessment. SARNET comprises most of the organisations involved in SA research in Europe, plus Canada. To reach these objectives, all the organisations networked in SARNET contributed to a joint Programme of Activities, which consisted of: Implementation of an advanced communication tool for accessing all project information, fostering exchange of information, and managing documents; Harmonization and re-orientation of the research programmes, and definition of new ones; Analysis of the experimental results provided by research programmes in order to elaborate a common understanding of relevant phenomena; Development of the ASTEC code (integral computer code used to predict the NPP behaviour during a postulated SA), which capitalizes in terms of physical models the knowledge produced within SARNET; Development of Scientific Databases in which all the results of research programmes are stored in a common format (DATANET); Development of a common methodology for Probabilistic Safety Assessment of NPPs; Development of short courses and writing a textbook on Severe Accidents for students and researchers; Promotion of personnel mobility amongst various European organisations. This paper presents the major achievements after four and a half years of operation of the

  5. "Medicine show." Alice in Doctorland.

    Science.gov (United States)

    1987-01-01

    This is an excerpt from the script of a 1939 play provided to the Institute of Social Medicine and Community Health by the Library of Congress Federal Theater Project Collection at George Mason University Library, Fairfax, Virginia, pages 2-1-8 thru 2-1-14. The Federal Theatre Project (FTP) was part of the New Deal program for the arts 1935-1939. Funded by the Works Progress Administration (WPA) its goal was to employ theater professionals from the relief rolls. A number of FTP plays deal with aspects of medicine and public health. Pageants, puppet shows and documentary plays celebrated progress in medical science while examining social controversies in medical services and the public health movement. "Medicine Show" sharply contrasts technological wonders with social backwardness. The play was rehearsed by the FTP but never opened because funding ended. A revised version ran on Broadway in 1940. The preceding comments are adapted from an excellent, well-illustrated review of five of these plays by Barabara Melosh: "The New Deal's Federal Theatre Project," Medical Heritage, Vol. 2, No. 1 (Jan/Feb 1986), pp. 36-47.

  6. Sales Training for Army Recruiter Success: Interviews with Excellent Recruiters

    Science.gov (United States)

    1987-11-01

    merit of an expert modeling system of the skills and strategies used by excel- lent Army recruiters. Neurolinguistic programming (NLP) was used as the...7. AUTHOR(&) 8. CONTRACT OR GRANT NUMBER(s) Steven R. Frieman 9. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT, TASK U.S...Recruiting 2M AUSTIRACT (rcnttm ame r orw am nssry i Identify by block number) s-This report describes a program of research on communication strategies and

  7. Appreciative Management – A Management based on Excellence

    OpenAIRE

    Simona PONEA

    2010-01-01

    Appreciative management support organizations, especially in the process of development of the human resources. Appreciative management considered as a management based on excellence, is based on the filosophy of appreciative inquiry. Any organization can apply this model starting with the process of recruitment. The process of employment requires each time a new beginning for the organization. New employees should be introduced carefully in the organizational culture and also must be provide...

  8. Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington’s disease

    Directory of Open Access Journals (Sweden)

    Zeng YX

    2016-04-01

    Full Text Available Yixuan Zeng,1,2,* Wenyuan Guo,1,* Guangqing Xu,3 Qinmei Wang,4 Luyang Feng,1,2 Simei Long,1 Fengyin Liang,1 Yi Huang,1 Xilin Lu,1 Shichang Li,5 Jiebin Zhou,5 Jean-Marc Burgunder,6 Jiyan Pang,5 Zhong Pei1,2 1Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Disease, The First Affiliated Hospital, Sun Yat-sen University, 2Guangzhou Center, Chinese Huntington’s Disease Network, 3Department of Rehabilitation, The First Affiliated Hospital, 4Key laboratory on Assisted Circulation, Ministry of Health, Department of Cardiovascular Medicine of the First Affiliated Hospital, 5School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 6Swiss Huntington’s Disease Center, Department of Neurology, University of Bern, Bern, Switzerland *These authors contributed equally to this work Abstract: Huntington’s disease is an autosomal-dominant neurodegenerative disorder, with chorea as the most prominent manifestation. The disease is caused by abnormal expansion of CAG codon repeats in the IT15 gene, which leads to the expression of a glutamine-rich protein named mutant Huntingtin (Htt. Because of its devastating disease burden and lack of valid treatment, development of more effective therapeutics for Huntington’s disease is urgently required. Xyloketal B, a natural product from mangrove fungus, has shown protective effects against toxicity in other neurodegenerative disease models such as Parkinson’s and Alzheimer’s diseases. To identify potential neuroprotective molecules for Huntington’s disease, six derivatives of xyloketal B were screened in a Caenorhabditis elegans Huntington’s disease model; all six compounds showed a protective effect. Molecular docking studies indicated that compound 1 could bind to residues GLN369 and GLN393 of the mutant Htt protein, forming a

  9. Academic excellence workshops in chemistry and physics

    Science.gov (United States)

    Mills, Susan Rose

    In the mid-1970's, Uri Treisman, at the University of California, Berkeley, developed an academic excellence workshop program that had important successes in increasing minority student achievement and persistence in calculus. The present dissertation research is an in-depth study of chemistry and physics workshops at the California State Polytechnic University, Pomona. Data for the first, longitudinal component of this study were obtained by tracking to Spring 1998 all workshop minority students, i.e., Latino, African American, and Native American workshop students, a random sample of non-workshop minority students, and a random sample of non-targeted students, i.e., Anglo and Asian students, enrolled in first-quarter General Chemistry or Physics during specific quarters of 1992 or 1993. Data for the second component were obtained by administering questionnaires, conducting interviews, and observing science students during Fall, 1996. Workshop participation was a significant predictor of first-quarter course grade for minority students in both chemistry and physics, while verbal and mathematics Scholastic Aptitude Test (SAT) scores were not significant predictors of beginning course grade for minority science students. The lack of predictive ability of the SAT and the importance of workshop participation in minority students' beginning science course performance are results with important implications for educators and students. In comparing pre-college achievement measures for workshop and non-targeted students, non-targeted students' mathematics SAT scores were significantly higher than chemistry and physics workshop students' scores. Nonetheless, workshop participation "leveled the field" as workshop and non-targeted students performed similarly in beginning science courses. Positive impacts of workshop participation on achievement, persistence, efficiency, social integration, and self-confidence support the continued and expanded funding of workshop programs

  10. MELTS_Excel: A Microsoft Excel-based MELTS interface for research and teaching of magma properties and evolution

    Science.gov (United States)

    Gualda, Guilherme A. R.; Ghiorso, Mark S.

    2015-01-01

    thermodynamic modeling software MELTS is a powerful tool for investigating crystallization and melting in natural magmatic systems. Rhyolite-MELTS is a recalibration of MELTS that better captures the evolution of silicic magmas in the upper crust. The current interface of rhyolite-MELTS, while flexible, can be somewhat cumbersome for the novice. We present a new interface that uses web services consumed by a VBA backend in Microsoft Excel©. The interface is contained within a macro-enabled workbook, where the user can insert the model input information and initiate computations that are executed on a central server at OFM Research. Results of simple calculations are shown immediately within the interface itself. It is also possible to combine a sequence of calculations into an evolutionary path; the user can input starting and ending temperatures and pressures, temperature and pressure steps, and the prevailing oxidation conditions. The program shows partial updates at every step of the computations; at the conclusion of the calculations, a series of data sheets and diagrams are created in a separate workbook, which can be saved independently of the interface. Additionally, the user can specify a grid of temperatures and pressures and calculate a phase diagram showing the conditions at which different phases are present. The interface can be used to apply the rhyolite-MELTS geobarometer. We demonstrate applications of the interface using an example early-erupted Bishop Tuff composition. The interface is simple to use and flexible, but it requires an internet connection. The interface is distributed for free from http://melts.ofm-research.org.

  11. A Fashion Show

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    <正>Story: The yearly fashion show day.The children take turns to walk on the stage and show the class their favorite clothes.Now it’s Joe’s and Phoebe’s turn.Joe walks on the stage and says,“My shorts are blue.Do you like my blue shorts?”On the other side of the stage, Phoebe is wearing her favorite pink skirt.“My skirt is pink.Do you like my pink skirt?”asks

  12. On not showing scalps

    DEFF Research Database (Denmark)

    Marselis, Randi Lorenz

    2016-01-01

    proposed by Janet Marstine, the editor of the Routledge Companion to Museum Ethics, I show how the museum succeeded in engaging users in questions of museum ethics. However, this specific debate on human remains in museums developed into an encounter between a global, museological discourse...

  13. Violence and TV Shows

    OpenAIRE

    ÖZTÜRK, Yrd. Doç. Dr. Şinasi

    2008-01-01

    This study aims to discuss theories on theviolent effects of TV shows on viewers, especiallyon children. Therefore, this study includes a briefdiscussion of definitions of violence, discussionof violence theories, main results of researcheson televised violence, measuring TV violence,perception of televised violence, individualdifferences and reactions to TV violence,aggressiveness and preferences for TV violence.

  14. Honored Teacher Shows Commitment.

    Science.gov (United States)

    Ratte, Kathy

    1987-01-01

    Part of the acceptance speech of the 1985 National Council for the Social Studies Teacher of the Year, this article describes the censorship experience of this honored social studies teacher. The incident involved the showing of a videotape version of the feature film entitled "The Seduction of Joe Tynan." (JDH)

  15. A Visionary Show

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Seduction. Distinction. Relax. Pulsation. These are the "style universes" on display at Première Vision, heralded as "The World’s Premiere Fabric Show." Started more than 35 years ago by 15 French weavers, Première Vision has expanded beyond its

  16. Honored Teacher Shows Commitment.

    Science.gov (United States)

    Ratte, Kathy

    1987-01-01

    Part of the acceptance speech of the 1985 National Council for the Social Studies Teacher of the Year, this article describes the censorship experience of this honored social studies teacher. The incident involved the showing of a videotape version of the feature film entitled "The Seduction of Joe Tynan." (JDH)

  17. Identification of rhesus macaque genital microbiota by 16S pyrosequencing shows similarities to human bacterial vaginosis: implications for use as an animal model for HIV vaginal infection.

    Science.gov (United States)

    Spear, Gregory T; Gilbert, Douglas; Sikaroodi, Masoumeh; Doyle, Lara; Green, Linda; Gillevet, Patrick M; Landay, Alan L; Veazey, Ronald S

    2010-02-01

    The composition of the lower genital tract microbiota in women is believed to affect the risk of sexually acquiring HIV. Since macaque genital microbiota could similarly impact vaginal infection with SIV we identified microbiota in 11 rhesus macaques using multitag pyrosequencing of the 16S rRNA gene. The microbiota was polymicrobial with a median of nine distinct bacterial taxa per macaque (range 3-16 taxa, each constituting 1% or more of the sequences). Taxa frequently found included Peptoniphilus, Sneathia, Porphyromonas, Mobiluncus, Atopobacter, Dialister, Thioreductor, Prevotella, and Streptococcus, many of which are also frequently found in women with bacterial vaginosis. Lactobacillus sequences (mostly L. johnsonii) were found in only four macaques but were not predominant in any (median of 0% of sequences, range 0-39%). All macaques were resampled 6 months after the first time point to determine the stability of the microbiota. The microbiota remained polymicrobial with a median of 10 taxa (range 6-18). Microbial patterns remained similar for six of the macaques, changed substantially in two, and had a mixed pattern in three. Significant sialidase enzyme activity, a marker of bacteria vaginosis in women, was detected in genital fluid from 9/11 and 8/11 macaques from the first and second time points, respectively. These results show that the macaque lower genital microbiota resembled a bacteria vaginosis-type microbiota in women and suggest that the microbiota of macaques in captivity promote rather than protect against vaginal infection with SIV. These results also suggest macaques could be used as an animal model to study some aspects of bacterial vaginosis.

  18. A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy.

    Science.gov (United States)

    Sciorati, Clara; Miglietta, Daniela; Buono, Roberta; Pisa, Viviana; Cattaneo, Dario; Azzoni, Emanuele; Brunelli, Silvia; Clementi, Emilio

    2011-09-01

    A resolutive therapy for muscular dystrophies, a heterogeneous group of genetic diseases leading to muscular degeneration and in the severe forms to death, is still lacking. Since inflammation and defects in nitric oxide generation are recognized key pathogenic events in muscular dystrophy, we have analysed the effects of a derivative of ibuprofen, NCX 320, belonging to the class of cyclooxygenase inhibiting nitric oxide donator (CINOD), in the α-sarcoglycan null mice, a severe mouse model of dystrophy. NCX 320 was administered daily in the diet for 8months starting 1month from weaning. Muscle functional recovery was evaluated by free wheel and treadmill tests at 8months. Serum creatine kinase activity, as well as the number of diaphragm inflammatory infiltrates and necrotic fibres, was measured as indexes of skeletal muscle damage. Muscle regeneration was evaluated in diaphragm and tibialis anterior muscles, measuring the numbers of centronucleated fibres and of myogenic precursor cells. NCX 320 mitigated muscle damage, reducing significantly serum creatine kinase activity, the number of necrotic fibres and inflammatory infiltrates. Moreover, NCX 320 stimulated muscle regeneration increasing significantly the number of myogenic precursor cells and regenerating fibres. All these effects concurred in inducing a significant improvement of muscle function, as assessed by both free wheel and treadmill tests. These results describe the properties of a new compound incorporating nitric oxide donation together with anti-inflammatory properties, showing that it is effective in slowing muscle dystrophy progression long term. Of importance, this new compound deserves specific attention for its potential in the therapy of muscular dystrophy given that ibuprofen is well tolerated in paediatric patients and with a profile of safety that makes it suitable for chronic treatment such as the one required in muscular dystrophies.

  19. Integrating Excel Spreadsheets into the Introductory Astronomy Laboratory

    Science.gov (United States)

    Keohane, Jonathan W.; Bartlett, J. L.; Bloom, S. D.; Foy, J. P.; Thurman, H. O.

    2008-05-01

    and the transparency of the earth's atmosphere, using a sundial and a calorimeter.Binary StarsThe students use photodiodes and oscilloscopes to measure the light curve of a model eclipsing binary star.Distance and Age of the PleiadesThe students gather data using the CLEA lab of the same name, but they plot an HR diagram along with a distance dependent standard main sequence using Excel. This lab uses luminosities and the inverse square law, instead of absolute magnitudes and the distance modulus.Hubble's LawThe students gather data using the CLEA lab of the same name, but they use Excel for all the analysis. This lab also favors the inverse square law over the distance modulus to calculate distances.

  20. Shanghai Shows Its Heart

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The city known as China’s economic powerhouse showed a more caring face as host of the Special Olympic Games Between October 2 and 11,the Special Olympics Summer Games were hosted in Shanghai,the first time the 40-year-old athletic com- petition for people with intellectual disabilities came to a developing country. This Special Olympics was also larger than all previous games in temps of the number of athletes.

  1. Center of excellence in laser medicine

    Energy Technology Data Exchange (ETDEWEB)

    Parrish, J.A.

    1992-01-01

    Achievements during the first six months of funding to prepare for a Center of Excellence in biomedical laser development include limited specific research projects within the Center's three broad interest areas, and program development to establish the Center and its activities. Progress in the three interest areas -- new medical laser systems development, optical diagnostics, and photosensitization, is reported. Feasibility studies and prototype development were emphasized, to enhance establishing a substantial Center through future support. Specific projects are an optimized laser-catheter system for reversal of vasospasm; optical detection of major skin burn depth and cancers using fluorescent drugs, and photosensitization of vascular tissues. In addition, an interdepartmental Laser Center was established at MGH to enhance collaborations and institutional committment to the Center of Excellence. Competitive postdoctoral research fellowships, with provision for matching funds from other departments, have been announced.

  2. Independent School Libraries Perspectives on excellence

    CERN Document Server

    HAND, DORCAS

    2010-01-01

    Independent School Libraries: Perspectives on Excellence offers readers insights into best practices in library services for school communities, using examples drawn from independent schools of various sizes, descriptions, and locations across the United States. Two overview essays introduce a statistical analysis of independent schools. Each of the remaining essays provides perspective on a different aspect of library practice, including staffing, advocacy, assessment, technology, collaboration, programs beyond the curriculum, intellectual freedom and privacy, budgeting, accreditation, disast

  3. Living excellence: life after Magnet designation.

    Science.gov (United States)

    Malloch, Kathy

    2009-01-01

    The achievement of Magnet recognition is the beginning of a new way of being as an organization. Strategies to support innovation leadership, value-based decision making, agility, sustainability of excellence, technology advancements, and lifelong learning are discussed within the framework of the Magnet organization. Behaviors and challenges of living the expectations of the Magnet organization are presented as opportunities to assist healthcare leaders in this important work.

  4. Gervais High School: 100% Committed to Excellence

    Science.gov (United States)

    Principal Leadership, 2013

    2013-01-01

    Gervais High School--with a senior class of 80 and a total enrollment of 337--may be small in size compared to its neighbors, but it has demonstrated over the last four years the ability to think big in pursuit of excellence. A decade ago, Gervais had a well-earned reputation in Oregon's Willamette Valley as a drug-ridden, gang-infested…

  5. [Biostatistics with Excel software or similar].

    Science.gov (United States)

    Couraud, S

    2009-12-01

    Many practitioners, especially young ones, find biostatistical analysis fastidious. However, there is a very usual tool for most basic calculations: Excel((c)) and similar software. This article proposes to help the reader, step by step, carry out many statistical functions. Although this paper does not avoid the advice of a specialist, it lets the reader become familiar with the rules of basic statistics and calculus.

  6. Leadership for Business Excellence: The Gender Perspective

    OpenAIRE

    DREW, EILEEN PATRICIA

    2008-01-01

    PUBLISHED The adoption of appropriate forms of leadership in response to modern organizational needs has become a major strand of management theory and underpins the pursuit of Total Quality/Business Excellence. With some notable exceptions, most of the leadership literature ignores the gender dimension of leadership This gender blindness and the association ofh management and leadership with men is being challenged through feminist/gender studies drawing upon ideas about po...

  7. An EXCEL macro for importing log ASCII standard (LAS) files into EXCEL worksheets

    Science.gov (United States)

    Özkaya, Sait Ismail

    1996-02-01

    An EXCEL 5.0 macro is presented for converting a LAS text file into an EXCEL worksheet. Although EXCEL has commands for importing text files and parsing text lines, LAS files must be decoded line-by-line because three different delimiters are used to separate fields of differing length. The macro is intended to eliminate manual decoding of LAS version 2.0. LAS is a floppy disk format for storage and transfer of log data as text files. LAS was proposed by the Canadian Well Logging Society. The present EXCEL macro decodes different sections of a LAS file, separates, and places the fields into different columns of an EXCEL worksheet. To import a LAS file into EXCEL without errors, the file must not contain any unrecognized symbols, and the data section must be the last section. The program does not check for the presence of mandatory sections or fields as required by LAS rules. Once a file is incorporated into EXCEL, mandatory sections and fields may be inspected visually.

  8. Visual Basic: Programming in Excel 2000%Excel 2000中使用Visual Basic编程

    Institute of Scientific and Technical Information of China (English)

    刘朝晖; 杨小影

    2002-01-01

    很多人都在使用Excel,但大多数人并不了解如何利用Excel 2000 Visual Basic语句访问Excel中工作表的Range对象、表格行和列等对象,以及如何利用Excel工作表常用的事件进行编程等,文章阐述了这些问题并在最后以一个编程实例详细地说明了如何在Excel 2000中使用Visual Basic编程.

  9. Antimalarial iron chelator, FBS0701, shows asexual and gametocyte Plasmodium falciparum activity and single oral dose cure in a murine malaria model.

    Directory of Open Access Journals (Sweden)

    Patricia Ferrer

    Full Text Available Iron chelators for the treatment of malaria have proven therapeutic activity in vitro and in vivo in both humans and mice, but their clinical use is limited by the unsuitable absorption and pharmacokinetic properties of the few available iron chelators. FBS0701, (S3"-(HO-desazadesferrithiocin-polyether [DADFT-PE], is an oral iron chelator currently in Phase 2 human studies for the treatment of transfusional iron overload. The drug has very favorable absorption and pharmacokinetic properties allowing for once-daily use to deplete circulating free iron with human plasma concentrations in the high µM range. Here we show that FBS0701 has inhibition concentration 50% (IC(50 of 6 µM for Plasmodium falciparum in contrast to the IC(50 for deferiprone and deferoxamine at 15 and 30 µM respectively. In combination, FBS0701 interfered with artemisinin parasite inhibition and was additive with chloroquine or quinine parasite inhibition. FBS0701 killed early stage P. falciparum gametocytes. In the P. berghei Thompson suppression test, a single dose of 100 mg/kg reduced day three parasitemia and prolonged survival, but did not cure mice. Treatment with a single oral dose of 100 mg/kg one day after infection with 10 million lethal P. yoelii 17XL cured all the mice. Pretreatment of mice with a single oral dose of FBS0701 seven days or one day before resulted in the cure of some mice. Plasma exposures and other pharmacokinetics parameters in mice of the 100 mg/kg dose are similar to a 3 mg/kg dose in humans. In conclusion, FBS0701 demonstrates a single oral dose cure of the lethal P. yoelii model. Significantly, this effect persists after the chelator has cleared from plasma. FBS0701 was demonstrated to remove labile iron from erythrocytes as well as enter erythrocytes to chelate iron. FBS0701 may find clinically utility as monotherapy, a malarial prophylactic or, more likely, in combination with other antimalarials.

  10. Research on Localization of Reality TV Shows with For-eign Model and Chinese Design:A Case Study on the Hit Show"Where are We Going, Dad?"%国外模式中国设计,电视真人秀节目的本土化改造研究--以《爸爸去哪儿》热播为例

    Institute of Scientific and Technical Information of China (English)

    吴妍彦; 刘珺

    2014-01-01

    "Where are We Going, Dad?"is a parent-child reality TV show presented by Hu'nan Satellite TV (HNTV) in October 2013, and it has been a big hit once broadcasting. The factors making it a success are not only the pursuit of perfection by its excellent production team, but also the innovative practice of lo-calization in its spread and operation. In the background of the current hit reality TV shows, this paper attempted to explore the latest idea of programs with foreign model and Chinese design from the perspective of localized spread, and reiterated that the success of a TV program needs the innovative practice of local-ized spread in addition to the reference of model and content.%《爸爸去哪儿》是湖南卫视于2013年10月推出的一档亲子真人秀节目,一经播出,该节目就引发了收视狂潮。《爸爸去哪儿》赢效因素不仅是由于优秀制作团队的精益求精,更在于它在传播运作上本土化的创新实践。本文试图在时下真人秀节目热映的背景下从本土化传播的角度探析国外模式中国设计的节目的最新理念,再次说明电视节目的成功除了模式借鉴和内容借鉴之外,还需要进行本土化的传播创新实践。

  11. 浅谈Excel XP的教学

    Institute of Scientific and Technical Information of China (English)

    江军强

    2008-01-01

    Excel XP是Office XP办公软件的重要组成郜分,本文通过讲述Excel XP的功能特点、Excel XP的重点难点、Excel XP的学习方法,结合具体的教学实践,介绍了如何掌握Excel XP的使用、提高Excel XP的教学效果.

  12. Developing nurses' intercultural/intraprofessional communication skills using the EXCELLence in Cultural Experiential Learning and Leadership (EXCELL) Social Interaction Maps.

    Science.gov (United States)

    Henderson, Saras; Barker, Michelle

    2017-09-27

    To examine how the use of Social Interaction Maps (SIMs), a tool in the EXCELL (EXCELLence in Cultural Experiential Learning and Leadership) Program can enhance the development of nurses' intercultural/intraprofessional communication skills. Nurses face communication challenges when interacting with others from similar background as well as those from a culturally and linguistically diverse (CALD) background. We used the EXCELL Program's Social Interaction Maps (SIMs) tool to foster intercultural/intraprofessional communication skills in nurses. SIMs describe verbal and non-verbal communication behaviours that model ways of communicating in a culturally appropriate manner. The Maps include four stages of an interaction, namely: Approach, Bridging, Communicating and Departing using the acronym ABCD. Qualitative approach was used with a purposeful sample of nurses enrolled in a postgraduate course. Fifteen participants were recruited. The SIM tool was taught to participants in a workshop where they engaged in sociocultural communication activities using scenarios. Participants were asked to apply SIMs in their workplaces. Six weeks later participants completed a semi-structured open-ended questionnaire and participated in a discussion forum on their experience of using SIMs. Data were content analysed. Four themes identified in the use of the SIMS were: (i) enhancing self-awareness of communication skills; (ii) promoting skills in being non-confrontational during difficult interactions; (iii) highlighting the importance of A (Approach) and B (Bridging) in interaction with others; (iv)awareness of how others interpret what is said C (Communicating), and discussing to resolve issues before closure D (Departing). Application of the EXCELL Social Interaction Mapping tool was shown to be useful in developing intercultural/intraprofessional communication skills in nurses. Professional development programs that incorporate EXCELL Social Interaction Maps can enhance nurses

  13. Not a "reality" show.

    Science.gov (United States)

    Wrong, Terence; Baumgart, Erica

    2013-01-01

    The authors of the preceding articles raise legitimate questions about patient and staff rights and the unintended consequences of allowing ABC News to film inside teaching hospitals. We explain why we regard their fears as baseless and not supported by what we heard from individuals portrayed in the filming, our decade-long experience making medical documentaries, and the full un-aired context of the scenes shown in the broadcast. The authors don't and can't know what conversations we had, what documents we reviewed, and what protections we put in place in each televised scene. Finally, we hope to correct several misleading examples cited by the authors as well as their offhand mischaracterization of our program as a "reality" show.

  14. Estimation of pharmacokinetic parameters from non-compartmental variables using Microsoft Excel.

    Science.gov (United States)

    Dansirikul, Chantaratsamon; Choi, Malcolm; Duffull, Stephen B

    2005-06-01

    This study was conducted to develop a method, termed 'back analysis (BA)', for converting non-compartmental variables to compartment model dependent pharmacokinetic parameters for both one- and two-compartment models. A Microsoft Excel spreadsheet was implemented with the use of Solver and visual basic functions. The performance of the BA method in estimating pharmacokinetic parameter values was evaluated by comparing the parameter values obtained to a standard modelling software program, NONMEM, using simulated data. The results show that the BA method was reasonably precise and provided low bias in estimating fixed and random effect parameters for both one- and two-compartment models. The pharmacokinetic parameters estimated from the BA method were similar to those of NONMEM estimation.

  15. Public medical shows.

    Science.gov (United States)

    Walusinski, Olivier

    2014-01-01

    In the second half of the 19th century, Jean-Martin Charcot (1825-1893) became famous for the quality of his teaching and his innovative neurological discoveries, bringing many French and foreign students to Paris. A hunger for recognition, together with progressive and anticlerical ideals, led Charcot to invite writers, journalists, and politicians to his lessons, during which he presented the results of his work on hysteria. These events became public performances, for which physicians and patients were transformed into actors. Major newspapers ran accounts of these consultations, more like theatrical shows in some respects. The resultant enthusiasm prompted other physicians in Paris and throughout France to try and imitate them. We will compare the form and substance of Charcot's lessons with those given by Jules-Bernard Luys (1828-1897), Victor Dumontpallier (1826-1899), Ambroise-Auguste Liébault (1823-1904), Hippolyte Bernheim (1840-1919), Joseph Grasset (1849-1918), and Albert Pitres (1848-1928). We will also note their impact on contemporary cinema and theatre.

  16. Excellence in the knowledge-based economy: from scientific to research excellence

    DEFF Research Database (Denmark)

    Sørensen, Mads P.; Bloch, Carter Walter; Young, Mitchell

    2016-01-01

    In 2013, the European Union (EU) unveiled its new ‘Composite Indicator for Scientific and Technological Research Excellence’. This is not an isolated occurrence; policy-based interest in excellence is growing all over the world. The heightened focus on excellence and, in particular, attempts....... This change is evidenced by the ‘Composite Indicator for Scientific and Technological Research Excellence’, its rationale and its components....

  17. University Students' Conceptions of an Excellent Physical Education Teacher in China

    Science.gov (United States)

    Song, Lihua; Chen, Junjun

    2013-01-01

    This study investigated how university students perceive an excellent physical education (PE) teacher at the university level. A sample of 2000 university students at four universities in China responded to a 53-item questionnaire. A 6-factor, 28-item model of an excellent teacher in PE was subsequently generated with a statistical good fit, using…

  18. University Students' Conceptions of an Excellent Physical Education Teacher in China

    Science.gov (United States)

    Song, Lihua; Chen, Junjun

    2013-01-01

    This study investigated how university students perceive an excellent physical education (PE) teacher at the university level. A sample of 2000 university students at four universities in China responded to a 53-item questionnaire. A 6-factor, 28-item model of an excellent teacher in PE was subsequently generated with a statistical good fit, using…

  19. Redesigning Schools to Reach Every Student with Excellent Teachers: Financial Planning Summary

    Science.gov (United States)

    Public Impact, 2012

    2012-01-01

    This brief summarizes the ways that schools and their teachers can simultaneously reach more students with excellent teaching, expand teachers' career opportunities, and sustainably fund higher pay and other priorities. This is based on Public Impact's school models that use job redesign and technology to extend the reach of excellent teachers to…

  20. ACTIVATED SLUDGE DESIGN ON MS.EXCEL 8.0

    Directory of Open Access Journals (Sweden)

    Köksal SARICAOĞLU

    2000-01-01

    Full Text Available In this study, the planing of the Activated Sludge Method used on Environmental Engineering, was done by MS Excel 8.0, which very commonly used for spread sheet design. The program contained five sections. They are; the "DATA" section to enter the available data for calculations, the "RESULTS" section to show the outcomes of calculations, the "DETERMINATION of DIMENSIONS" section to determine the dimensions of the reactor, the "CALCULATION of AIR DIFFUSER" section to calculate the dimensions and capacity of air diffuser and the "EVALUATION" section to evaluate the results of calculations according to the criteria. The aim of this study was, to demonstrate that every engineer ca do easily needed programs related to her or his field using Excel's functions although can not know about any program language.

  1. Automated Image-based modeling, low-cost survey methods to show the hidden geometry. The Church of S. Eligio in Naples

    Directory of Open Access Journals (Sweden)

    Mara Capone

    2015-07-01

    Full Text Available  The paper is a part of a research on Angevin Gothic buildings in Naples. The aim is to define a methodological path to understand Gothic in Naples in relation to the original French models. The Church of S.Eligio, built in 1270 by Charles I of Anjou, is one of the most important buildings to reconstruct the development of Gothic in Naples. Through the study of archival records and the survey, aimed at defining the exact geometric configuration, the goal was to reconstruct the evolution of the building, to identify existing and alleged regulator lines. In our research we tested Automated immage based modeling, techniques based on the use of photographic images for 3D data collection, to formulate and verify hypotheses, to compare the geometric configuration with the theoretical models, to analyze the layers and to reveal the regulator lines

  2. Excel 2013 for human resource management statistics a guide to solving practical problems

    CERN Document Server

    Quirk, Thomas J

    2016-01-01

    This book shows how Microsoft Excel is able to teach human resource management statistics effectively. Similar to the previously published Excel 2010 for Human Resource Management Statistics, it is a step-by-step exercise-driven guide for students and practitioners who need to master Excel to solve practical human resource management problems. If understanding statistics isn’t your strongest suit, you are not especially mathematically-inclined, or if you are wary of computers, this is the right book for you. Excel, a widely available computer program for students and managers, is also an effective teaching and learning tool for quantitative analyses in human resource management courses. Its powerful computational ability and graphical functions make learning statistics much easier than in years past. However, Excel 2013 for Human Resource Management Statistics: A Guide to Solving Practical Problems is the first book to capitalize on these improvements by teaching students and managers how to apply Excel to ...

  3. Excel 2013 for physical sciences statistics a guide to solving practical problems

    CERN Document Server

    Quirk, Thomas J; Horton, Howard F

    2016-01-01

    This book shows the capabilities of Microsoft Excel in teaching physical sciences statistics effectively. Similar to the previously published Excel 2010 for Physical Sciences Statistics, this book is a step-by-step exercise-driven guide for students and practitioners who need to master Excel to solve practical science problems. If understanding statistics isn’t your strongest suit, you are not especially mathematically-inclined, or if you are wary of computers, this is the right book for you. Excel, a widely available computer program for students and managers, is also an effective teaching and learning tool for quantitative analyses in science courses. Its powerful computational ability and graphical functions make learning statistics much easier than in years past. However, Excel 2013 for Physical Sciences Statistics: A Guide to Solving Practical Problems is the first book to capitalize on these improvements by teaching students and managers how to apply Excel to statistical techniques necessary in their ...

  4. Excel 2016 for business statistics a guide to solving practical problems

    CERN Document Server

    Quirk, Thomas J

    2016-01-01

    This book shows the capabilities of Microsoft Excel in teaching business statistics effectively. Similar to the previously published Excel 2010 for Business Statistics, this book is a step-by-step exercise-driven guide for students and practitioners who need to master Excel to solve practical business problems. If understanding statistics isn’t your strongest suit, you are not especially mathematically-inclined, or if you are wary of computers, this is the right book for you. Excel, a widely available computer program for students and managers, is also an effective teaching and learning tool for quantitative analyses in business courses. Its powerful computational ability and graphical functions make learning statistics much easier than in years past. However, Excel 2016 for Business Statistics: A Guide to Solving Practical Problems is the first book to capitalize on these improvements by teaching students and managers how to apply Excel to statistical techniques necessary in their courses and work. Each ch...

  5. Excel 2016 for social science statistics a guide to solving practical problems

    CERN Document Server

    Quirk, Thomas J

    2016-01-01

    This book shows the capabilities of Microsoft Excel in teaching social science statistics effectively. Similar to the previously published Excel 2013 for Social Sciences Statistics, this book is a step-by-step exercise-driven guide for students and practitioners who need to master Excel to solve practical social science problems. If understanding statistics isn’t your strongest suit, you are not especially mathematically-inclined, or if you are wary of computers, this is the right book for you. Excel, a widely available computer program for students and managers, is also an effective teaching and learning tool for quantitative analyses in social science courses. Its powerful computational ability and graphical functions make learning statistics much easier than in years past. However, Excel 2016 for Social Science Statistics: A Guide to Solving Practical Problems is the first book to capitalize on these improvements by teaching students and managers how to apply Excel to statistical techniques necessary in ...

  6. Excel 2016 for engineering statistics a guide to solving practical problems

    CERN Document Server

    Quirk, Thomas J

    2016-01-01

    This book shows the capabilities of Microsoft Excel in teaching engineering statistics effectively. Similar to the previously published Excel 2013 for Engineering Statistics, this book is a step-by-step exercise-driven guide for students and practitioners who need to master Excel to solve practical engineering problems. If understanding statistics isn’t your strongest suit, you are not especially mathematically-inclined, or if you are wary of computers, this is the right book for you. Excel, a widely available computer program for students and managers, is also an effective teaching and learning tool for quantitative analyses in engineering courses. Its powerful computational ability and graphical functions make learning statistics much easier than in years past. However,Excel 2016 for Engineering Statistics: A Guide to Solving Practical Problems is the first book to capitalize on these improvements by teaching students and managers how to apply Excel to statistical techniques necessary in their courses and...

  7. The new indicators of accounts receivable excellence.

    Science.gov (United States)

    Lampi, G L

    1996-01-01

    Calculation of AR days will continue to be a valuable internal measurement tool of accounts receivable excellence. As healthcare organizations move toward managed care through a mix of reimbursement systems--many with conflicting incentives--the director of patient accounting must approach each system separately and ensure that the hospital receives all of the reimbursement to which it is entitled. The director of patient accounting must understand the industry and recognize that healthcare reimbursement will almost certainly continue to become more complex rather than simpler. Creativity will be a necessity, and good luck will be an advantage.

  8. Training for excellence; Formacion para la excelencia

    Energy Technology Data Exchange (ETDEWEB)

    Lucas Soriano, S.

    2011-07-01

    The reliability of the Human Factor is based on competence, which is understood to be the body of knowledge, skills and attitudes that, acquired through training and experience, lead to excellent performance and have a bearing on the economic efficiency, improvement and availability of the operation of nuclear installations. In order to improve this reliability, training programs are designed and developed methodology using a Systematic Approach to Training (SAT); they are implemented in learning environments as close as possible to reality or in the workplace itself, with highly qualified instructors and a level of demand according to the job position and the requirements of national and international qualification standards. (Author) 7 refs.

  9. Assessing the "Rothstein Falsification Test": Does It Really Show Teacher Value-Added Models Are Biased? CEDR Working Paper No. 2012 1.3

    Science.gov (United States)

    Goldhaber, Dan; Chaplin, Duncan

    2012-01-01

    In a provocative and influential paper, Jesse Rothstein (2010) finds that standard value added models (VAMs) suggest implausible future teacher effects on past student achievement, a finding that obviously cannot be viewed as causal. This is the basis of a falsification test (the Rothstein falsification test) that appears to indicate bias in VAM…

  10. Cross-biome transplants of plant litter show decomposition models extend to a broader climatic range but lose predictability at the decadal time scale

    Science.gov (United States)

    William S. Currie; Mark E. Harmon; Ingrid C. Burke; Stephen C. Hart; William J. Parton; Whendee L. Silver

    2009-01-01

    We analyzed results from 10-year long field incubations of foliar and fine root litter from the Long-term lntersite Decomposition Experiment Team (LIDET) study. We tested whether a variety of climate and litter quality variables could be used to develop regression models of decomposition parameters across wide ranges in litter quality and climate and whether these...

  11. Le choix de l'excellence

    CERN Document Server

    Collins, Jim

    2012-01-01

    Dix ans après le succès mondial de De la performance à l'excellence (Good to Great), Jim Collins et son associé Morten T. Hansen s'interrogent ici sur la nature de l excellence en période d incertitude. Pourquoi, dans un contexte chaotique, certaines entreprises sont florissantes et d autres non ? Comment, en ces temps troublés, réussir à diriger et vaincre l adversité pour dominer son marché ? La chance peut-elle sérieusement être envisagée comme un facteur de réussite ? À l issue d un programme de recherche ambitieux et rigoureux qui a duré neuf ans, les auteurs exposent dans cet ouvrage les nouveaux principes pour bâtir une entreprise réellement excellente. Leurs conclusions sont, comme toujours, étonnantes. Ils soulignent notamment que la course à l innovation n est pas toujours la meilleure voie à suivre, que discipline et créativité peuvent aller de concert et que malgré le changement permanent, les meilleures décisions sont rarement prises dans l urgence. Quant aux leaders, on...

  12. Multi-Chemotherapeutic Schedules Containing the pan-FGFR Inhibitor ARQ 087 are Safe and Show Antitumor Activity in Different Xenograft Models.

    Science.gov (United States)

    Chilà, Rosaria; Hall G, Terence; Abbadessa, Giovanni; Broggini, Massimo; Damia, Giovanna

    2017-02-02

    ARQ 087 is a multi-tyrosine kinase inhibitor with potent activity against the FGFR receptor family, currently in Phase I clinical studies for the treatment of advanced solid tumors. The compound has a very safe profile and induces tumor regressions in FGFR-driven models. The feasibility of combining ARQ 087 with chemotherapy was investigated in FGFR deregulated human xenografts. Nude mice were transplanted subcutaneously with H1581, and when tumor masses reached 150 mg, were randomized to receive vehicle, ARQ 087, paclitaxel, carboplatin as single agents or in combination. Similar experimental conditions were applied in nude mice bearing SNU16 and MFE296 xenografts, with the inclusion of capecitabine in the former xenograft model. In the different xenograft models, the drugs given as single agents ranged from very active to partially active. The double combinations were more active than the single ones, but the triple combinations were the most active. In particular, the combination of ARQ 087 + paclitaxel + carboplatin in H1581 bearing mice was able to induce tumor regression in all the mice, with 6/8 mice tumor free at day 140 after tumor transplant. Of note, no toxic deaths nor premature stopping or delaying of drug administration were observed. The data herein reported demonstrated the feasibility of using xenografts models for poli-chemotherapeutic trials mimicking the best standard of care in treatment of specific tumor type and that ARQ 087, a new pan-FGFR inhibitor, can be safely combined with standard cytotoxic chemotherapeutic drugs with apparently no sign of cumulative toxicity and an associated increased antitumor effect.

  13. Use of a serum-free epidermal culture model to show deleterious effects of epidermal growth factor on morphogenesis and differentiation.

    Science.gov (United States)

    Chen, C S; Lavker, R M; Rodeck, U; Risse, B; Jensen, P J

    1995-01-01

    The presence of serum has limited the utility of many culture models for the study of cytokine effects because its complexity and variability can confound the interpretation of data. In the present study, a serum-free skin co-culture model was used to investigate the effect of exogenous epidermal growth factor (EGF) on epidermal proliferation and differentiation. Human keratinocytes cultured on collagen rafts at the air-liquid interface produced a well-differentiated epithelium that resembled normal epidermis. Keratin filaments, membrane-coating granules, and keratohyalin granules were all observed. Epidermal differentiation markers keratin K1/K10, involucrin, and transglutaminase were localized in most of the suprabasal layers, whereas profilaggrin/filaggrin was confined to the granular layers and stratum corneum. In the continual presence of 10-20 ng/mL EGF, the epidermis was less organized, thinner, and less proliferative. EGF also depressed several indicators of differentiation: The number of keratohyalin granules and membrane-coating granules was greatly decreased; antigen expression of profilaggrin/filaggrin appeared diminished by immunocytochemical staining; frequent nuclear retention was noted in the relatively thickened stratum corneum-like layers. As detected by immunohistochemical staining, the expression of EGF receptor in the epidermis was reduced by exogenous EGF. These data illustrate that EGF cannot be considered a simple mitogen. Our findings also underscore the importance of using sophisticated culture models to assess complex cytokine effects that may be dependent on the architecture of a differentiating epidermis.

  14. F1 (CBA×C57) mice show superior hearing in old age relative to their parental strains: hybrid vigor or a new animal model for "golden ears"?

    Science.gov (United States)

    Frisina, Robert D; Singh, Ameet; Bak, Matthew; Bozorg, Sara; Seth, Rahul; Zhu, Xiaoxia

    2011-09-01

    Age-related hearing loss - presbycusis - is the most common communication problem and third most prevalent chronic medical disorder of the aged. The CBA and C57BL/6 mouse strains are useful for studying features of presbycusis. The CBA loses its hearing slowly, like most humans. Because the C57 develops a rapid, high frequency hearing loss by middle age, it has an "old" ear but a relatively young brain, a model that helps separate peripheral (cochlear) from central (brain) etiologies. This field of sensory neuroscience lacks a good mouse model for the 5-10% of aged humans with normal cochlear sensitivity, but who have trouble perceiving speech in background noise. We hypothesized that F1 (CBA×C57) hybrids would have better hearing than either parental strain. Measurements of peripheral auditory sensitivity supported this hypothesis, however, a rapid decline in the auditory efferent feedback system, did not. Therefore, F1s might be an optimal model for studying cases where the peripheral hearing is quite good in old age; thereby allowing isolation of central auditory changes due to brain neurodegeneration.

  15. Measuring performance at trade shows

    DEFF Research Database (Denmark)

    Hansen, Kåre

    2004-01-01

    Trade shows is an increasingly important marketing activity to many companies, but current measures of trade show performance do not adequately capture dimensions important to exhibitors. Based on the marketing literature's outcome and behavior-based control system taxonomy, a model is built...... that captures a outcome-based sales dimension and four behavior-based dimensions (i.e. information-gathering, relationship building, image building, and motivation activities). A 16-item instrument is developed for assessing exhibitors perceptions of their trade show performance. The paper presents evidence...

  16. John Walkenbach's Favorite Excel 2010 Tips and Tricks

    CERN Document Server

    Walkenbach, John

    2010-01-01

    Build robust Excel 2010 apps quickly and efficiently. Known as "Mr. Spreadsheet," John Walkenbach's name is synonymous with excellence in computer books that explain the complexities of various topics. With this collection of favorite Excel tips and tricks, you get a unique look at ways to make Excel 2010 more efficient than you ever imagined. Packed with easy-to-understand advice regarding all aspects of Excel, this book shares improved ways of speeding up application development with Excel and maximizing the power of Excel to create robust applications.: Addresses the extensive cha

  17. A model for aryl hydrocarbon receptor-activated gene expression shows potency and efficacy changes and predicts squelching due to competition for transcription co-activators.

    Directory of Open Access Journals (Sweden)

    Ted W Simon

    Full Text Available A stochastic model of nuclear receptor-mediated transcription was developed based on activation of the aryl hydrocarbon receptor (AHR by 2,3,7,8-tetrachlorodibenzodioxin (TCDD and subsequent binding the activated AHR to xenobiotic response elements (XREs on DNA. The model was based on effects observed in cells lines commonly used as in vitro experimental systems. Following ligand binding, the AHR moves into the cell nucleus and forms a heterodimer with the aryl hydrocarbon nuclear translocator (ARNT. In the model, a requirement for binding to DNA is that a generic coregulatory protein is subsequently bound to the AHR-ARNT dimer. Varying the amount of coregulator available within the nucleus altered both the potency and efficacy of TCDD for inducing for transcription of CYP1A1 mRNA, a commonly used marker for activation of the AHR. Lowering the amount of available cofactor slightly increased the EC50 for the transcriptional response without changing the efficacy or maximal response. Further reduction in the amount of cofactor reduced the efficacy and produced non-monotonic dose-response curves (NMDRCs at higher ligand concentrations. The shapes of these NMDRCs were reminiscent of the phenomenon of squelching. Resource limitations for transcriptional machinery are becoming apparent in eukaryotic cells. Within single cells, nuclear receptor-mediated gene expression appears to be a stochastic process; however, intercellular communication and other aspects of tissue coordination may represent a compensatory process to maintain an organism's ability to respond on a phenotypic level to various stimuli within an inconstant environment.

  18. Cell therapy using retinal progenitor cells shows therapeutic effect in a chemically-induced rotenone mouse model of Leber hereditary optic neuropathy.

    Science.gov (United States)

    Mansergh, Fiona C; Chadderton, Naomi; Kenna, Paul F; Gobbo, Oliviero L; Farrar, G Jane

    2014-11-01

    Primary mitochondrial disorders occur at a prevalence of one in 10 000; ∼50% of these demonstrate ocular pathology. Leber hereditary optic neuropathy (LHON) is the most common primary mitochondrial disorder. LHON results from retinal ganglion cell pathology, which leads to optic nerve degeneration and blindness. Over 95% of cases result from one of the three common mutations in mitochondrial genes MTND1, MTND4 and MTND6, which encode elements of the complex I respiratory chain. Various therapies for LHON are in development, for example, intravitreal injection of adeno-associated virus carrying either the yeast NDI1 gene or a specific subunit of mammalian Complex I have shown visual improvement in animal models. Given the course of LHON, it is likely that in many cases prompt administration may be necessary before widespread cell death. An alternative approach for therapy may be the use of stem cells to protect visual function; this has been evaluated by us in a rotenone-induced model of LHON. Freshly dissected embryonic retinal cells do not integrate into the ganglion cell layer (GCL), unlike similarly obtained photoreceptor precursors. However, cultured retinal progenitor cells can integrate in close proximity to the GCL, and act to preserve retinal function as assessed by manganese-enhanced magnetic resonance imaging, optokinetic responses and ganglion cell counts. Cell therapies for LHON therefore represent a promising therapeutic approach, and may be of particular utility in treating more advanced disease.

  19. Simplifying CEA through Excel, VBA, and Subeq

    Science.gov (United States)

    Foster, Ryan

    2004-01-01

    Many people use compound equilibrium programs for very different reasons, varying from refrigerators to light bulbs to rockets. A commonly used equilibrium program is CEA. CEA can take various inputs such as pressure, temperature, and volume along with numerous reactants and run them through equilibrium equations to obtain valuable output information, including products formed and their relative amounts. A little over a year ago, Bonnie McBride created the program subeq with the goal to simplify the calling of CEA. Subeq was also designed to be called by other programs, including Excel, through the use of Visual Basic for Applications (VBA). The largest advantage of using Excel is that it allows the user to input the information in a colorful and user-friendly environment while allowing VBA to run subeq, which is in the form of a FORTRAN DLL (Dynamic Link Library). Calling subeq in this form makes it much faster than if it were converted to VBA. Since subeq requires such large lists of reactant and product names, all of which can't be passed in as an array, subeq had to be changed to accept very long strings of reactants and products. To pass this string and adjust the transfer of input and output parameters, the subeq DLL had to be changed. One program that does this is Compaq Visual FORTRAN, which allows DLLs to be edited, debugged, and compiled. Compaq Visual FORTRAN uses FORTRAN 90/95, which has additional features to that of FORTRAN 77. My goals this summer include finishing up the excel spreadsheet of subeq, which I started last summer, and putting it on the Internet so that others can use it without having to download my spreadsheet. To finish up the spreadsheet I will need to work on debugging current options and problems. I will also work on making it as robust as possible, so that all errors that may arise will be clearly communicated to the user. New features will be added old ones will be changed as I receive comments from people using the spreadsheet

  20. The it girl''s guide to becoming an Excel diva

    CERN Document Server

    Babaian, Ani

    2009-01-01

    Apply Excel daily and smooth out life''s wrinklesWho knew a spreadsheet could do as much for you as your favorite moisturizer? Become a Microsoft Excel Diva with this sassy guide and discover what hip IT Girls already know: smart is beautiful. Impress the heck out of everyone at work with your stylish reports. Do a budget and see exactly what you can spend on shoes. Get better organized. Who has time for dull technical manuals? Learn all of Microsoft Excel''s secrets in this girl-talk guide.Welcome to the party!Relax, refresh, and reward yourself at the end of each chapter with fun, stress-reducing chats, like why soy Chai lattes are better than regular lattes. Don''t miss these gems!* Meet Microsoft(r) Excel(r) 2007, the Louis Vuitton of spreadsheets* Join the conversation with these basic Excel terms* Learn the fine art of Excel formulas and functions* Dress up Excel data with SmartArt, WordArt, and other chic accessories* Build a shopping spree budget from scratch* Show off by adding Excel data into Word a...

  1. Human papillomavirus 16 L1-E7 chimeric virus like particles show prophylactic and therapeutic efficacy in murine model of cervical cancer.

    Science.gov (United States)

    Sharma, Chandresh; Dey, Bindu; Wahiduzzaman, Mohammed; Singh, Neeta

    2012-08-03

    Cervical cancer is found to be associated with human papillomavirus (HPV) infection, with HPV16 being the most prevalent. An effective vaccine against HPV can thus, be instrumental in controlling cervical cancer. An ideal HPV vaccine should aim to generate both humoral immune response to prevent new infection as well as cell-mediated immunity to eliminate established infection. In this study, we have generated a potential preventive and therapeutic candidate vaccine against HPV16. We expressed and purified recombinant HPV16 L1(ΔN26)-E7(ΔC38) protein in E. coli which was assembled into chimeric virus like particles (CVLPs) in vitro. These CVLPs were able to induce neutralizing antibodies and trigger cell-mediated immune response, in murine model of cervical cancer, exhibiting antitumor efficacy. Hence, this study has aimed to provide a vaccine candidate possessing both, prophylactic and therapeutic efficacy against HPV16 associated cervical cancer.

  2. N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity.

    Science.gov (United States)

    Abeywardane, Asitha; Caviness, Gary; Choi, Younggi; Cogan, Derek; Gao, Amy; Goldberg, Daniel; Heim-Riether, Alexander; Jeanfavre, Debra; Klein, Elliott; Kowalski, Jennifer A; Mao, Wang; Miller, Craig; Moss, Neil; Ramsden, Philip; Raymond, Ernest; Skow, Donna; Smith-Keenan, Lana; Snow, Roger J; Wu, Frank; Wu, Jiang-Ping; Yu, Yang

    2016-11-01

    Compound 1 ((4-amino-3,5-dichlorophenyl)-1-(4-methylpiperidin-1-yl)-4-(2-nitroimidazol-1-yl)-1-oxobutane-2-sulfonamido) was discovered to be a 690nM antagonist of human CCR10 Ca(2+) flux. Optimization delivered (2R)-4-(2-cyanopyrrol-1-yl)-S-(1H-indol-4-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutane-2-sulfonamido (eut-22) that is 300 fold more potent a CCR10 antagonist than 1 and eliminates potential toxicity, mutagenicity, and drug-drug-interaction liabilities often associated with nitroaryls and anilines. eut-22 is highly selective over other GPCR's, including a number of other chemokine receptors. Finally, eut-22 is efficacious in the murine DNFB model of contact hypersensitivity. The efficacy of this compound provides further evidence for the role of CCR10 in dermatological inflammatory conditions.

  3. A national neurological excellence centers network.

    Science.gov (United States)

    Pazzi, S; Cristiani, P; Cavallini, A

    1998-02-01

    The most relevant problems related to the management of neurological disorders are (i) the frequent hospitalization in nonspecialist departments, with the need for neurological consultation, and (ii) the frequent requests of GPs for highly specialized investigations that are very expensive and of little value in arriving at a correct diagnosis. In 1996, the Consorzio di Bioingegneria e Informatica Medica in Italy realized the CISNet project (in collaboration with the Consorzio Istituti Scientifici Neuroscienze e Tecnologie Biomediche and funded by the Centro Studi of the National Public Health Council) for the implementation of a national neurological excellence centers network (CISNet). In the CISNet project, neurologists will be able to give on-line interactive consultation and off-line consulting services identifying correct diagnostic/therapeutic procedures, evaluating the need for both examination in specialist centers and admission to specialized centers, and identifying the most appropriate ones.

  4. Guaranteeing CERN’s excellence: consolidate experience

    CERN Multimedia

    Staff Association

    2014-01-01

    For its missions CERN requires staff with solid experience in all its domains of activity The Organization has several missions: fundamental research, technical developments and innovation, training the several hundreds of associates, fellows and students, while at the same time taking care of more than 10000 users. In order to guarantee excellence in all of these areas, CERN has to put in place an efficient personnel policy. Such a policy must allow the Organization to recruit collaborators with the highest competence from all Member States, and to keep and motivate them during their entire professional career. But, more importantly, the Organization has to be able to count on a stable workforce. It needs staff with experience gained over a long period in the fields of accelerators, detectors, and operating procedures, if it is to fulfil successfully its important mission of training and knowledge transfer, which is very much appreciated by our Member states, since it highlights a visible return on invest...

  5. Total quality management: achieving service excellence.

    Science.gov (United States)

    Adelson, R

    1997-01-01

    Total Quality Management (TQM) provides a philosophy and a method for organizational renewal and redesign. It is based on the principle that productive work is accomplished through processes. Improving these processes requires the office team to objectively measure performance, discover root causes of problems, take corrective action, determine the effect of these actions, and secure achievements. TQM is a technique that provides a series of steps and set of tools. Through staff involvement and a desire for quality improvement, organizations involved in total quality note the accompanying satisfaction in taking constructive action, improving patient relations, and achieving service excellence. In today's competitive delivery environment, implementation of TQM can result in more satisfied patients, higher staff morale, and a more effective office team.

  6. VIP Visit Her Excellency Dr Dalia Grybauskaite

    CERN Multimedia

    2016-01-01

    Her Excellency Dr Dalia Grybauskaite President Republic of Lithuania. Wednesday 20 January 2016. General introduction to CERN’s activities by CERN Director-General F. Gianotti. CERN Director-General introduces CMS Collaboration Deputy Spokesperson K. Borras and CMS Lithuanians A. Rinkevicius with V. Rapsevicius. Met by J. Shiers, IT Department Data Preservation Project Leader, and walk to 1st floor Data Centre Visit Point. CERN Data Centre Visit Point, 1st floor, building 513. View the robotic arms of the CERN IT data centre automated libraries (J. Shiers) CERN Computer Centre, building 513, level -1. Physics hands-on and virtual visit with a High School class in Lithuania (S. Schmeling) CERN S’cool Lab, building 143. Meeting with the Lithuanian community at CERN. Signature of the Guest Book with CERN Director-General witnessed by the Lithuanian community at CERN. Family photograph with the Lithuanian community at CERN.

  7. Excel spreadsheet in teaching numerical methods

    Science.gov (United States)

    Djamila, Harimi

    2017-09-01

    One of the important objectives in teaching numerical methods for undergraduates’ students is to bring into the comprehension of numerical methods algorithms. Although, manual calculation is important in understanding the procedure, it is time consuming and prone to error. This is specifically the case when considering the iteration procedure used in many numerical methods. Currently, many commercial programs are useful in teaching numerical methods such as Matlab, Maple, and Mathematica. These are usually not user-friendly by the uninitiated. Excel spreadsheet offers an initial level of programming, which it can be used either in or off campus. The students will not be distracted with writing codes. It must be emphasized that general commercial software is required to be introduced later to more elaborated questions. This article aims to report on a teaching numerical methods strategy for undergraduates engineering programs. It is directed to students, lecturers and researchers in engineering field.

  8. The Multi-Target Drug M30 Shows Pro-Cognitive and Anti-Inflammatory Effects in a Rat Model of Alzheimer's Disease.

    Science.gov (United States)

    Pimentel, Luisa S; Allard, Simon; Do Carmo, Sonia; Weinreb, Orly; Danik, Marc; Hanzel, Cecilia E; Youdim, Moussa B; Cuello, A Claudio

    2015-01-01

    Current therapies for Alzheimer's disease (AD) offer partial symptomatic relief and do not modify disease progression. There is substantial evidence indicating a disease onset years before clinical diagnosis, at which point no effective therapy has been found. In this study, we investigated the efficacy of a new multi-target drug, M30, at relatively early stages of the AD-like amyloid pathology in a robust rat transgenic model. McGill-R-Thy1-APP transgenic rats develop the full AD-like amyloid pathology in a progressive fashion, and have a minimal genetic burden. McGill rats were given 5 mg/kg M30 or vehicle per os, every 2 days for 4 months, starting at a stage where the transgenic animals suffer detectable cognitive impairments. At the completion of the treatment, cognitive functions were assessed with Novel Object Location and Novel Object Recognition tests. The brains were then analyzed to assess amyloid-β (Aβ) burden and the levels of key inflammatory markers. Long-term treatment with M30 was associated with both the prevention and the reversal of transgene-related cognitive decline. The effects on cognition were accompanied by a shift of the Aβ-immunoreactive material toward an amyloid plaque aggregated molecular form, diminished molecular signs of CNS inflammation and a change in microglia morphology toward a surveying phenotype. This study is the first to demonstrate the therapeutic potential of M30 in a rat model of the AD amyloid pathology. It provides a rationale for further investigations with M30 and with potential multi-target approaches to delay, prevent or reverse the progression the AD pathology at early disease-stages.

  9. PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel.

    Science.gov (United States)

    Zhang, Yong; Huo, Meirong; Zhou, Jianping; Xie, Shaofei

    2010-09-01

    This study presents PKSolver, a freely available menu-driven add-in program for Microsoft Excel written in Visual Basic for Applications (VBA), for solving basic problems in pharmacokinetic (PK) and pharmacodynamic (PD) data analysis. The program provides a range of modules for PK and PD analysis including noncompartmental analysis (NCA), compartmental analysis (CA), and pharmacodynamic modeling. Two special built-in modules, multiple absorption sites (MAS) and enterohepatic circulation (EHC), were developed for fitting the double-peak concentration-time profile based on the classical one-compartment model. In addition, twenty frequently used pharmacokinetic functions were encoded as a macro and can be directly accessed in an Excel spreadsheet. To evaluate the program, a detailed comparison of modeling PK data using PKSolver and professional PK/PD software package WinNonlin and Scientist was performed. The results showed that the parameters estimated with PKSolver were satisfactory. In conclusion, the PKSolver simplified the PK and PD data analysis process and its output could be generated in Microsoft Word in the form of an integrated report. The program provides pharmacokinetic researchers with a fast and easy-to-use tool for routine and basic PK and PD data analysis with a more user-friendly interface.

  10. Enhancing Mathematical Graphical Displays in Excel through Animation

    Directory of Open Access Journals (Sweden)

    Deane Arganbright

    2006-01-01

    Full Text Available Enhancing Mathematical Graphical Displays in Excel through AnimationThe use of spreadsheets in teaching mathematics has increased significantly in recent years. One can implement mathematical algorithms, models, visualizations, and applications naturally and effectively through interactive spreadsheet constructions and creative graphical displays. This paper demonstrates techniques that enable educators to design animated graphical displays in their spreadsheet constructions in order to produce powerful classroom demonstrations to enhance mathematical understanding, while also presenting students with new ideas for incorporating attractive visual components in their mathematical assignments and projects.

  11. Appreciative Management – A Management based on Excellence

    Directory of Open Access Journals (Sweden)

    Simona PONEA

    2010-04-01

    Full Text Available Appreciative management support organizations, especially in the process of development of the human resources. Appreciative management considered as a management based on excellence, is based on the filosophy of appreciative inquiry. Any organization can apply this model starting with the process of recruitment. The process of employment requires each time a new beginning for the organization. New employees should be introduced carefully in the organizational culture and also must be provided with an confortable environment. Appreciative management provide an innovative way of development of any organization. Is very important as well that the manager know how to apply amoung with this the process of peer education and also peer supervision.

  12. Macrophage inflammatory protein-1α shows predictive value as a risk marker for subjects and sites vulnerable to bone loss in a longitudinal model of aggressive periodontitis.

    Directory of Open Access Journals (Sweden)

    Daniel H Fine

    Full Text Available Improved diagnostics remains a fundamental goal of biomedical research. This study was designed to assess cytokine biomarkers that could predict bone loss (BL in localized aggressive periodontitis. 2,058 adolescents were screened. Two groups of 50 periodontally healthy adolescents were enrolled in the longitudinal study. One group had Aggregatibacter actinomycetemcomitans (Aa, the putative pathogen, while the matched cohort did not. Cytokine levels were assessed in saliva and gingival crevicular fluid (GCF. Participants were sampled, examined, and radiographed every 6 months for 2-3 years. Disease was defined as radiographic evidence of BL. Saliva and GCF was collected at each visit, frozen, and then tested retrospectively after detection of BL. Sixteen subjects with Aa developed BL. Saliva from Aa-positive and Aa-negative healthy subjects was compared to subjects who developed BL. GCF was collected from 16 subjects with BL and from another 38 subjects who remained healthy. GCF from BL sites in the 16 subjects was compared to healthy sites in these same subjects and to healthy sites in subjects who remained healthy. Results showed that cytokines in saliva associated with acute inflammation were elevated in subjects who developed BL (i.e., MIP-1α MIP-1β IL-α, IL-1β and IL-8; p<0.01. MIP-1α was elevated 13-fold, 6 months prior to BL. When MIP-1α levels were set at 40 pg/ml, 98% of healthy sites were below that level (Specificity; whereas, 93% of sites with BL were higher (Sensitivity, with comparable Predictive Values of 98%; p<0.0001; 95% C.I. = 42.5-52.7. MIP-1α consistently showed elevated levels as a biomarker for BL in both saliva and GCF, 6 months prior to BL. MIP-1α continues to demonstrate its strong candidacy as a diagnostic biomarker for both subject and site vulnerability to BL.

  13. 75 FR 37776 - Office of Postsecondary Education; Overview Information Centers of Excellence for Veteran Student...

    Science.gov (United States)

    2010-06-30

    ... responsibility is to coordinate the model program; monitoring the rates of veteran student enrollment... document the applicant's current activities to support veteran student enrollment, persistence, and... Office of Postsecondary Education; Overview Information Centers of Excellence for Veteran Student...

  14. Analysis of Knowledge Management Effectiveness on Business Excellence Using System Dynamics

    Directory of Open Access Journals (Sweden)

    mohammad dehghani saryazdi

    2014-05-01

    Full Text Available It can be claimed that an organization is approaching excellence when it achieves acceptable results besides providing appropriate infrastructures and following right processes. Excellence models, such as European Foundation of Quality Management (EFQM, try to establish a tradeoff between enablers and outcomes in evaluating organizational performance. One of those enablers is Knowledge Management (KM, which is gaining increasing attentions nowadays regarding the soaring significance of knowledge resources. In order to evaluate the KM processes, a comprehensive model is required, which should be able to capture all aspects of KM. One of such models is Knowledge Management Assessment Tool (KMAT. This research is an effort to find the relationship between knowledge and business excellence through system dynamics tool. In other words, this research exploits system dynamics in order to measure the effects of KM on business excellence using a dynamic model based upon a combination of KMAT and EFQM.

  15. Analysis of the Fgfr2C342Y mouse model shows condensation defects due to misregulation of Sox9 expression in prechondrocytic mesenchyme

    Science.gov (United States)

    Peskett, Emma; Kumar, Samin; Baird, William; Jaiswal, Janhvi; Li, Ming; Patel, Priyanca; Britto, Jonathan A.

    2017-01-01

    ABSTRACT Syndromic craniosynostosis caused by mutations in FGFR2 is characterised by developmental pathology in both endochondral and membranous skeletogenesis. Detailed phenotypic characterisation of features in the membranous calvarium, the endochondral cranial base and other structures in the axial and appendicular skeleton has not been performed at embryonic stages. We investigated bone development in the Crouzon mouse model (Fgfr2C342Y) at pre- and post-ossification stages to improve understanding of the underlying pathogenesis. Phenotypic analysis was performed by whole-mount skeletal staining (Alcian Blue/Alizarin Red) and histological staining of sections of CD1 wild-type (WT), Fgfr2C342Y/+ heterozygous (HET) and Fgfr2C342Y/C342Y homozygous (HOM) mouse embryos from embryonic day (E)12.5-E17.5 stages. Gene expression (Sox9, Shh, Fgf10 and Runx2) was studied by in situ hybridisation and protein expression (COL2A1) by immunohistochemistry. Our analysis has identified severely decreased osteogenesis in parts of the craniofacial skeleton together with increased chondrogenesis in parts of the endochondral and cartilaginous skeleton in HOM embryos. The Sox9 expression domain in tracheal and basi-cranial chondrocytic precursors at E13.5 in HOM embryos is increased and expanded, correlating with the phenotypic observations which suggest FGFR2 signalling regulates Sox9 expression. Combined with abnormal staining of type II collagen in pre-chondrocytic mesenchyme, this is indicative of a mesenchymal condensation defect. An expanded spectrum of phenotypic features observed in the Fgfr2C342Y/C342Y mouse embryo paves the way towards better understanding the clinical attributes of human Crouzon–Pfeiffer syndrome. FGFR2 mutation results in impaired skeletogenesis; however, our findings suggest that many phenotypic aberrations stem from a primary failure of pre-chondrogenic/osteogenic mesenchymal condensation and link FGFR2 to SOX9, a principal regulator of skeletogenesis

  16. Program impact pathway analysis of a social franchise model shows potential to improve infant and young child feeding practices in Vietnam.

    Science.gov (United States)

    Nguyen, Phuong H; Menon, Purnima; Keithly, Sarah C; Kim, Sunny S; Hajeebhoy, Nemat; Tran, Lan M; Ruel, Marie T; Rawat, Rahul

    2014-10-01

    By mapping the mechanisms through which interventions are expected to achieve impact, program impact pathway (PIP) analysis lays out the theoretical causal links between program activities, outcomes, and impacts. This study examines the pathways through which the Alive & Thrive (A&T) social franchise model is intended to improve infant and young child feeding (IYCF) practices in Vietnam. Mixed methods were used, including qualitative interviews with franchise management board members (n = 12), surveys with health providers (n = 120), counseling observations (n = 160), and household surveys (n = 2045). Six PIP components were assessed: 1) franchise management, 2) training and IYCF knowledge of health providers, 3) service delivery, 4) program exposure and utilization, 5) maternal behavioral determinants (knowledge, beliefs, and intentions) toward optimal IYCF practices, and 6) IYCF practices. Data were collected from A&T-intensive areas (A&T-I; mass media + social franchise) and A&T-nonintensive areas (A&T-NI; mass media only) by using a cluster-randomized controlled trial design. Data from 2013 were compared with baseline where similar measures were available. Results indicate that mechanisms are in place for effective management of the franchise system, despite challenges to routine monitoring. A&T training was associated with increased capacity of providers, resulting in higher-quality IYCF counseling (greater technical knowledge and communication skills during counseling) in A&T-I areas. Franchise utilization increased from 10% in 2012 to 45% in 2013 but fell below the expected frequency of 9-15 contacts per mother-child dyad. Improvements in breastfeeding knowledge, beliefs, intentions, and practices were greater among mothers in A&T-I areas than among those in A&T-NI areas. In conclusion, there are many positive changes along the impact pathway of the franchise services, but challenges in utilization and demand creation should be addressed to achieve the full

  17. A novel underuse model shows that inactivity but not ovariectomy determines the deteriorated material properties and geometry of cortical bone in the tibia of adult rats.

    Science.gov (United States)

    Miyagawa, Kazuaki; Kozai, Yusuke; Ito, Yumi; Furuhama, Takami; Naruse, Kouji; Nonaka, Kiichi; Nagai, Yumiko; Yamato, Hideyuki; Kashima, Isamu; Ohya, Keiichi; Aoki, Kazuhiro; Mikuni-Takagaki, Yuko

    2011-07-01

    Our goal in this study was to determine to what extent the physiologic consequences of ovariectomy (OVX) in bones are exacerbated by a lack of daily activity such as walking. We forced 14-week-old female rats to be inactive for 15 weeks with a unique experimental system that prevents standing and walking while allowing other movements. Tibiae, femora, and 4th lumbar vertebrae were analyzed by peripheral quantitative computed tomography (pQCT), microfocused X-ray computed tomography (micro-CT), histology, histomorphometry, Raman spectroscopy, and the three-point bending test. Contrary to our expectation, the exacerbation was very much limited to the cancellous bone parameters. Parameters of femur and tibia cortical bone were affected by the forced inactivity but not by OVX: (1) cross-sectional moment of inertia was significantly smaller in Sham-Inactive rat bones than that of their walking counterparts; (2) the number of sclerostin-positive osteocytes per unit cross-sectional area was larger in Sham-Inactive rat bones than in Sham-Walking rat bones; and (3) material properties such as ultimate stress of inactive rat tibia was lower than that of their walking counterparts. Of note, the additive effect of inactivity and OVX was seen only in a few parameters, such as the cancellous bone mineral density of the lumbar vertebrae and the structural parameters of cancellous bone in the lumbar vertebrae/tibiae. It is concluded that the lack of daily activity is detrimental to the strength and quality of cortical bone in the femur and tibia of rats, while lack of estrogen is not. Our inactive rat model, with the older rats, will aid the study of postmenopausal osteoporosis, the etiology of which may be both hormonal and mechanical.

  18. A novel therapeutic with two SNAP-25 inactivating proteases shows long-lasting anti-hyperalgesic activity in a rat model of neuropathic pain.

    Science.gov (United States)

    Wang, Jiafu; Casals, Laura; Zurawski, Tomas; Meng, Jianghui; Moriarty, Orla; Nealon, John; Edupuganti, Om Prakash; Dolly, Oliver

    2017-03-24

    A pressing need exists for long-acting, non-addictive medicines to treat chronic pain, a major societal burden. Botulinum neurotoxin type A (BoNT/A) complex - a potent, specific and prolonged inhibitor of neuro-exocytosis - gives some relief in several pain disorders, but not for all patients. A study objective was to modify BoNT/A to overcome its inability to block transmitter release elicited by high [Ca(2+)]i and increase its restricted analgesic effects. This was achieved by fusing a BoNT/A gene to that for the light chain (LC) of type/E. The resultant purified protein, LC/E-BoNT/A, entered cultured sensory neurons and, unlike BoNT/A, inhibited release of calcitonin gene-related peptide evoked by capsaicin. Western blotting revealed that this improvement could be due to a more extensive truncation by LC/E of synaptosomal-associated protein of Mr = 25 k, essential for neuro-exocytosis. When tested in a rat spared nerve injury (SNI) model, a single intra-plantar (IPL) injection of LC/E-BoNT/A alleviated for ∼2 weeks mechanical and cold hyper-sensitivities, in a dose-dependent manner. The highest non-paralytic dose (75 U/Kg, IPL) proved significantly more efficacious than BoNT/A (15 U/Kg, IPL) or repeated systemic pregabalin (10 mg/ml, intraperitoneal), a clinically-used pain modulator. Effects of repeated or delayed injections of this fusion protein highlighted its analgesic potential. Attenuation of mechanical hyperalgesia was extended by a second administration when the effect of the first had diminished. When injected 5 weeks after injury, LC/E-BoNT/A also reversed fully-established mechanical and cold hyper-sensitivity. Thus, combining advantageous features of BoNT/E and/A yields an efficacious, locally-applied and long-acting anti-hyperalgesic.

  19. Next-generation sequencing shows West Nile virus quasispecies diversification after a single passage in a carrion crow (Corvus corone) in vivo infection model.

    Science.gov (United States)

    Dridi, M; Rosseel, T; Orton, R; Johnson, P; Lecollinet, S; Muylkens, B; Lambrecht, B; Van Borm, S

    2015-10-01

    West Nile virus (WNV) occurs as a population of genetic variants (quasispecies) infecting a single animal. Previous low-resolution viral genetic diversity estimates in sampled wild birds and mosquitoes, and in multiple-passage adaptation studies in vivo or in cell culture, suggest that WNV genetic diversification is mostly limited to the mosquito vector. This study investigated genetic diversification of WNV in avian hosts during a single passage using next-generation sequencing. Wild-captured carrion crows were subcutaneously infected using a clonal Middle-East WNV. Blood samples were collected 2 and 4 days post-infection. A reverse-transcription (RT)-PCR approach was used to amplify the WNV genome directly from serum samples prior to next-generation sequencing resulting in an average depth of at least 700 ×  in each sample. Appropriate controls were sequenced to discriminate biologically relevant low-frequency variants from experimentally introduced errors. The WNV populations in the wild crows showed significant diversification away from the inoculum virus quasispecies structure. By contrast, WNV populations in intracerebrally infected day-old chickens did not diversify from that of the inoculum. Where previous studies concluded that WNV genetic diversification is only experimentally demonstrated in its permissive insect vector species, we have experimentally shown significant diversification of WNV populations in a wild bird reservoir species.

  20. The Use of Operational Excellence Principles in a University Hospital

    Directory of Open Access Journals (Sweden)

    Eric R. Edelman

    2017-07-01

    Full Text Available The introduction of Operational Excellence in the Maastricht University Medical Center (MUMC+ has been the first of its kind and scale for a university hospital. The policy makers of the MUMC+ have combined different elements from various other business, management, and healthcare philosophies and frameworks into a unique mix. This paper summarizes the journey of developing this system and its most important aspects. Special attention is paid to the role of the operating rooms and the improvements that have taken place there, because of their central role in the working of the hospital. The MUMC+ is the leading tertiary healthcare center for the South-East region of The Netherlands and beyond. Regional, national, and international developments encouraged the MUMC+ to start significantly reorganizing its care processes from 2009 onward. First experiments with Lean Six Sigma and Business Modeling were combined with lessons learned from other centers around the world to form the MUMC+’s own type of Operational Excellence. At the time of writing, many improvement projects of different types have been successfully completed. Every single department in the hospital now uses Operational Excellence and design thinking in general as a method to develop new models of care. An evaluation in 2014 revealed several opportunities for improvement. A large number of projects were in progress, but 75% of all projects had not been completed, despite the first projects being initiated back in 2012. This led to a number of policy changes, mainly focusing on more intensive monitoring of projects and trying to do more improvement projects directly under the responsibility of the line manager. Focusing on patient value, continuous improvement, and the reduction of waste have proven to be very fitting principles for healthcare in general and specifically for application in a university hospital. Approaching improvement at a systems level while directly involving the

  1. The Use of Operational Excellence Principles in a University Hospital.

    Science.gov (United States)

    Edelman, Eric R; Hamaekers, Ankie E W; Buhre, Wolfgang F; van Merode, Godefridus G

    2017-01-01

    The introduction of Operational Excellence in the Maastricht University Medical Center (MUMC+) has been the first of its kind and scale for a university hospital. The policy makers of the MUMC+ have combined different elements from various other business, management, and healthcare philosophies and frameworks into a unique mix. This paper summarizes the journey of developing this system and its most important aspects. Special attention is paid to the role of the operating rooms and the improvements that have taken place there, because of their central role in the working of the hospital. The MUMC+ is the leading tertiary healthcare center for the South-East region of The Netherlands and beyond. Regional, national, and international developments encouraged the MUMC+ to start significantly reorganizing its care processes from 2009 onward. First experiments with Lean Six Sigma and Business Modeling were combined with lessons learned from other centers around the world to form the MUMC+'s own type of Operational Excellence. At the time of writing, many improvement projects of different types have been successfully completed. Every single department in the hospital now uses Operational Excellence and design thinking in general as a method to develop new models of care. An evaluation in 2014 revealed several opportunities for improvement. A large number of projects were in progress, but 75% of all projects had not been completed, despite the first projects being initiated back in 2012. This led to a number of policy changes, mainly focusing on more intensive monitoring of projects and trying to do more improvement projects directly under the responsibility of the line manager. Focusing on patient value, continuous improvement, and the reduction of waste have proven to be very fitting principles for healthcare in general and specifically for application in a university hospital. Approaching improvement at a systems level while directly involving the people on the work

  2. The Use of Operational Excellence Principles in a University Hospital

    Science.gov (United States)

    Edelman, Eric R.; Hamaekers, Ankie E. W.; Buhre, Wolfgang F.; van Merode, Godefridus G.

    2017-01-01

    The introduction of Operational Excellence in the Maastricht University Medical Center (MUMC+) has been the first of its kind and scale for a university hospital. The policy makers of the MUMC+ have combined different elements from various other business, management, and healthcare philosophies and frameworks into a unique mix. This paper summarizes the journey of developing this system and its most important aspects. Special attention is paid to the role of the operating rooms and the improvements that have taken place there, because of their central role in the working of the hospital. The MUMC+ is the leading tertiary healthcare center for the South-East region of The Netherlands and beyond. Regional, national, and international developments encouraged the MUMC+ to start significantly reorganizing its care processes from 2009 onward. First experiments with Lean Six Sigma and Business Modeling were combined with lessons learned from other centers around the world to form the MUMC+’s own type of Operational Excellence. At the time of writing, many improvement projects of different types have been successfully completed. Every single department in the hospital now uses Operational Excellence and design thinking in general as a method to develop new models of care. An evaluation in 2014 revealed several opportunities for improvement. A large number of projects were in progress, but 75% of all projects had not been completed, despite the first projects being initiated back in 2012. This led to a number of policy changes, mainly focusing on more intensive monitoring of projects and trying to do more improvement projects directly under the responsibility of the line manager. Focusing on patient value, continuous improvement, and the reduction of waste have proven to be very fitting principles for healthcare in general and specifically for application in a university hospital. Approaching improvement at a systems level while directly involving the people on the work

  3. A Drosophila model of dominant inclusion body myopathy type 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects.

    Science.gov (United States)

    Suggs, Jennifer A; Melkani, Girish C; Glasheen, Bernadette M; Detor, Mia M; Melkani, Anju; Marsan, Nathan P; Swank, Douglas M; Bernstein, Sanford I

    2017-06-01

    Individuals with inclusion body myopathy type 3 (IBM3) display congenital joint contractures with early-onset muscle weakness that becomes more severe in adulthood. The disease arises from an autosomal dominant point mutation causing an E706K substitution in myosin heavy chain type IIa. We have previously expressed the corresponding myosin mutation (E701K) in homozygous Drosophila indirect flight muscles and recapitulated the myofibrillar degeneration and inclusion bodies observed in the human disease. We have also found that purified E701K myosin has dramatically reduced actin-sliding velocity and ATPase levels. Since IBM3 is a dominant condition, we now examine the disease state in heterozygote Drosophila in order to gain a mechanistic understanding of E701K pathogenicity. Myosin ATPase activities in heterozygotes suggest that approximately equimolar levels of myosin accumulate from each allele. In vitro actin sliding velocity rates for myosin isolated from the heterozygotes were lower than the control, but higher than for the pure mutant isoform. Although sarcomeric ultrastructure was nearly wild type in young adults, mechanical analysis of skinned indirect flight muscle fibers revealed a 59% decrease in maximum oscillatory power generation and an approximately 20% reduction in the frequency at which maximum power was produced. Rate constant analyses suggest a decrease in the rate of myosin attachment to actin, with myosin spending decreased time in the strongly bound state. These mechanical alterations result in a one-third decrease in wing beat frequency and marginal flight ability. With aging, muscle ultrastructure and function progressively declined. Aged myofibrils showed Z-line streaming, consistent with the human heterozygote phenotype. Based upon the mechanical studies, we hypothesize that the mutation decreases the probability of the power stroke occurring and/or alters the degree of movement of the myosin lever arm, resulting in decreased in vitro

  4. A Drosophila model of dominant inclusion body myopathy type 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects

    Directory of Open Access Journals (Sweden)

    Jennifer A. Suggs

    2017-06-01

    Full Text Available Individuals with inclusion body myopathy type 3 (IBM3 display congenital joint contractures with early-onset muscle weakness that becomes more severe in adulthood. The disease arises from an autosomal dominant point mutation causing an E706K substitution in myosin heavy chain type IIa. We have previously expressed the corresponding myosin mutation (E701K in homozygous Drosophila indirect flight muscles and recapitulated the myofibrillar degeneration and inclusion bodies observed in the human disease. We have also found that purified E701K myosin has dramatically reduced actin-sliding velocity and ATPase levels. Since IBM3 is a dominant condition, we now examine the disease state in heterozygote Drosophila in order to gain a mechanistic understanding of E701K pathogenicity. Myosin ATPase activities in heterozygotes suggest that approximately equimolar levels of myosin accumulate from each allele. In vitro actin sliding velocity rates for myosin isolated from the heterozygotes were lower than the control, but higher than for the pure mutant isoform. Although sarcomeric ultrastructure was nearly wild type in young adults, mechanical analysis of skinned indirect flight muscle fibers revealed a 59% decrease in maximum oscillatory power generation and an approximately 20% reduction in the frequency at which maximum power was produced. Rate constant analyses suggest a decrease in the rate of myosin attachment to actin, with myosin spending decreased time in the strongly bound state. These mechanical alterations result in a one-third decrease in wing beat frequency and marginal flight ability. With aging, muscle ultrastructure and function progressively declined. Aged myofibrils showed Z-line streaming, consistent with the human heterozygote phenotype. Based upon the mechanical studies, we hypothesize that the mutation decreases the probability of the power stroke occurring and/or alters the degree of movement of the myosin lever arm, resulting in

  5. Excel 2010 all-in-one for dummies

    CERN Document Server

    Harvey, Greg

    2010-01-01

    A comprehensive, up-to-date, user-friendly guide to Excel 2010 Excel is the standard for spreadsheet applications and is used worldwide, but it's not always user-friendly. That makes it a perfect For Dummies topic, and this handy all-in-one guide covers all the essentials, the new features, how to analyze data with Excel, and much more. Eight minibooks address Excel basics, worksheet design, formulas and functions, worksheet collaboration and review, charts and graphics, data management, data analysis, and Excel and VBA.Excel is the leading spreadsheet/data analysis s

  6. Fabrication of high nitrogen austenitic stainless steels with excellent mechanical and pitting corrosion properties

    Institute of Scientific and Technical Information of China (English)

    Hua-bing Li; Zhou-hua Jiang; Yang Cao; Zu-rui Zhang

    2009-01-01

    18Cr18Mn2Mo0.9N high nitrogen austenitic stainless steel exhibits high strength and good ductility at room temperature. The steel shows typical duc-tile-brittle transition behavior and excellent pitting corrosion resistance properties.

  7. Females excel at basic face perception.

    Science.gov (United States)

    McBain, Ryan; Norton, Dan; Chen, Yue

    2009-02-01

    Females are generally better than males at recognizing facial emotions. However, it is not entirely clear whether and in what way females may also excel at non-affective face recognition. Here, we tested males and females on two perceptual face recognition tasks that involved only neutral expressions: detection and identity discrimination. On face detection (Experiment 1), females were significantly more accurate than males in detecting upright faces. This gender difference was reduced during inverted face detection, and not present during tree detection, suggesting that the magnitude of the gender difference for performance co-varies with the extent to which face processing mechanisms are involved. On facial identity discrimination (Experiment 2), females again outperformed males, particularly when face images were masked by visual noise, or the delay between comparison face images was extended from 0.5 to 3s. These results reveal a female advantage in processing face-specific information and underscore the role of perceptual factors in socially relevant gender differences.

  8. CERN, a laboratory of social excellence

    CERN Multimedia

    Staff Association

    2012-01-01

    The HR 2012 Forum, where Human Resources (HR) professionals meet and present innovative services and tools in the HR sector, was held on 3rd and 4th October at Palexpo, Geneva. CERN won the 3rd HR Innovation Award for the Long-Term Saved Leave Scheme (LTSLS) for its novelty and innovation. The award was presented to Jean-Marc Saint Viteux, Deputy-Head of HR Department. This is excellent news for our Organization. One can say that the Long-Term Saved Leave Scheme (LTSLS) originated from proposals by the Staff Association in 1996, based on general considerations on a framework for flexible working time arrangements. This article recalls the history of our work on this topic, which resulted in the implementation of PRP and various variants of a saved leave scheme. In a future issue of Echo, we will come back on other elements of CERN's social policy that we would like to improve upon to ensure a better work-life balance.  Indeed, a good employer must offer a working environment that allows an...

  9. The nature of excellent clinicians at an academic health science center: a qualitative study.

    Science.gov (United States)

    Mahant, Sanjay; Jovcevska, Vesna; Wadhwa, Anupma

    2012-12-01

    To understand the nature of excellent clinicians at an academic health science center by exploring how and why excellent clinicians achieve high performance. From 2008 to 2010, the authors conducted a qualitative study using a grounded theory approach. Members of the Clinical Advisory Committee in the Department of Pediatrics at the University of Toronto nominated peers whom they saw as excellent clinicians. The authors then conducted in-depth interviews with the most frequently nominated clinicians. They audio-recorded and transcribed the interviews and coded the transcripts to identify emergent themes. From interviews with 13 peer-nominated, excellent clinicians, a model emerged. Dominant themes fell into three categories: (1) core philosophy, (2) deliberate activities, and (3) everyday practice. Excellent clinicians are driven by a core philosophy defined by high intrinsic motivation and passion for patient care and humility. They refine their clinical skills through two deliberate activities-reflective clinical practice and scholarship. Their high performance in everyday practice is characterized by clinical skills and cognitive ability, people skills, engagement, and adaptability. A rich theory emerged explaining how excellent clinicians, driven by a core philosophy and engaged in deliberate activities, achieve high performance in everyday practice. This theory of the nature of excellent clinicians provides a holistic perspective of individual performance, informs medical education, supports faculty career development, and promotes clinical excellence in the culture of academic medicine.

  10. Excel 2013 for educational and psychological statistics a guide to solving practical problems

    CERN Document Server

    Quirk, Thomas J

    2015-01-01

    This is the first book to show the capabilities of Microsoft Excel to teach educational and psychological statistics effectively. It is a step-by-step exercise-driven guide for students and practitioners who need to master Excel to solve practical problems in education and psychology. If understanding statistics isn’t your strongest suit, you are not especially mathematically-inclined, or if you are wary of computers, this is the right book for you. Excel, a widely available computer program for students and practitioners, is also an effective teaching and learning tool for quantitative analyses in statistics courses. Its powerful computational ability and graphical functions make learning statistics much easier than in years past. However, Excel 2013 for Educational and Psychological Statistics: A Guide to Solving Practical Problems is the first book to capitalize on these improvements by teaching students and practitioners how to apply Excel to statistical techniques necessary in their courses and work. E...

  11. Excel 2013 for health services management statistics a guide to solving practical problems

    CERN Document Server

    Quirk, Thomas J

    2016-01-01

    This book shows the capabilities of Microsoft Excel to teach health services management statistics effectively. Similar to the previously published Excel 2010 for Health Services Management Statistics, this book is a step-by-step exercise-driven guide for students and practitioners who need to master Excel to solve practical health services management problems. If understanding statistics isn’t your strongest suit, you are not especially mathematically-inclined, or if you are wary of computers, this is the right book for you. Excel, a widely available computer program for students and managers, is also an effective teaching and learning tool for quantitative analyses in health services management courses. Its powerful computational ability and graphical functions make learning statistics much easier than in years past. However, Excel 2013 for Health Services Management Statistics: A Guide to Solving Practical Problems is the first book to capitalize on these improvements by teaching students and managers ho...

  12. Excel 2010 for health services management statistics a guide to solving practical problems

    CERN Document Server

    Quirk, Thomas J

    2014-01-01

    This is the first book to show the capabilities of Microsoft Excel to teach health services management statistics effectively. It is a step-by-step exercise-driven guide for students and practitioners who need to master Excel to solve practical health services management problems. If understanding statistics isn’t your strongest suit, you are not especially mathematically-inclined, or if you are wary of computers, this is the right book for you.   Excel, a widely available computer program for students and managers, is also an effective teaching and learning tool for quantitative analyses in health services management courses. Its powerful computational ability and graphical functions make learning statistics much easier than in years past. However, Excel 2010 for Health Services Management Statistics: A Guide to Solving Practical Problems is the first book to capitalize on these improvements by teaching students and managers how to apply Excel to statistical techniques necessary in their courses and work....

  13. Excel 2016 for educational and psychological statistics a guide to solving practical problems

    CERN Document Server

    Quirk, Thomas J

    2016-01-01

    This book shows the capabilities of Microsoft Excel in teaching educational and psychological statistics effectively. Similar to the previously published Excel 2013 for Educational and Psychological Statistics, this book is a step-by-step exercise-driven guide for students and practitioners who need to master Excel to solve practical education and psychology problems. If understanding statistics isn’t your strongest suit, you are not especially mathematically-inclined, or if you are wary of computers, this is the right book for you. Excel, a widely available computer program for students and managers, is also an effective teaching and learning tool for quantitative analyses in education and psychology courses. Its powerful computational ability and graphical functions make learning statistics much easier than in years past. However, Excel 2016 for Educational and Psychological Statistics: A Guide to Solving Practical Problems is the first book to capitalize on these improvements by teaching students and man...

  14. Excel 2016 for health services management statistics a guide to solving problems

    CERN Document Server

    Quirk, Thomas J

    2016-01-01

    This book shows the capabilities of Microsoft Excel in teaching health services management statistics effectively. Similar to the previously published Excel 2013 for Health Services Management Statistics, this book is a step-by-step exercise-driven guide for students and practitioners who need to master Excel to solve practical health service management problems. If understanding statistics isn’t your strongest suit, you are not especially mathematically-inclined, or if you are wary of computers, this is the right book for you. Excel, a widely available computer program for students and managers, is also an effective teaching and learning tool for quantitative analyses in health service courses. Its powerful computational ability and graphical functions make learning statistics much easier than in years past. However, Excel 2016 for Health Services Management Statistics: A Guide to Solving Practical Problems is the first book to capitalize on these improvements by teaching students and managers how to apply...

  15. Excel 2016 for marketing statistics a guide to solving practical problems

    CERN Document Server

    Quirk, Thomas J

    2016-01-01

    This is the first book to show the capabilities of Microsoft Excel in teaching marketing statistics effectively. It is a step-by-step exercise-driven guide for students and practitioners who need to master Excel to solve practical marketing problems. If understanding statistics isn’t your strongest suit, you are not especially mathematically-inclined, or if you are wary of computers, this is the right book for you. Excel, a widely available computer program for students and managers, is also an effective teaching and learning tool for quantitative analyses in marketing courses. Its powerful computational ability and graphical functions make learning statistics much easier than in years past. However, Excel 2016 for Marketing Statistics: A Guide to Solving Practical Problems is the first book to capitalize on these improvements by teaching students and managers how to apply Excel to statistical techniques necessary in their courses and work. Each chapter explains statistical formulas and directs the reader t...

  16. Excel 2016 for human resource management statistics a guide to solving practical problems

    CERN Document Server

    Quirk, Thomas J

    2016-01-01

    This book shows the capabilities of Microsoft Excel in teaching human resource management statistics effectively. Similar to the previously published Excel 2013 for Human Resource Management Statistics, this book is a step-by-step exercise-driven guide for students and practitioners who need to master Excel to solve practical human resource management problems. If understanding statistics isn’t your strongest suit, you are not especially mathematically-inclined, or if you are wary of computers, this is the right book for you. Excel, a widely available computer program for students and managers, is also an effective teaching and learning tool for quantitative analyses in human resource management courses. Its powerful computational ability and graphical functions make learning statistics much easier than in years past. However, Excel 2016 for Human Resource Management Statistics: A Guide to Solving Practical Problems is the first book to capitalize on these improvements by teaching students and managers how ...

  17. Tokyo Motor Show 2003; Tokyo Motor Show 2003

    Energy Technology Data Exchange (ETDEWEB)

    Joly, E.

    2004-01-01

    The text which follows present the different techniques exposed during the 37. Tokyo Motor Show. The report points out the great tendencies of developments of the Japanese automobile industry. The hybrid electric-powered vehicles or those equipped with fuel cells have been highlighted by the Japanese manufacturers which allow considerable budgets in the research of less polluting vehicles. The exposed models, although being all different according to the manufacturer, use always a hybrid system: fuel cell/battery. The manufacturers have stressed too on the intelligent systems for navigation and safety as well as on the design and comfort. (O.M.)

  18. Three-dimensional echocardiography with tissue harmonic imaging shows excellent reproducibility in assessment of left ventricular volumes

    DEFF Research Database (Denmark)

    Kim, Won Yong; Søgaard, Peter; Egeblad, Henrik;

    2001-01-01

    We studied the reproducibility of repeated measurements of left ventricular (LV) volumes by 2-dimensional (biplane method of disks) and 3-dimensional echocardiography (coaxial scanning) with tissue harmonic imaging. Ten healthy subjects underwent estimation of LV volumes by transthoracic echocard......We studied the reproducibility of repeated measurements of left ventricular (LV) volumes by 2-dimensional (biplane method of disks) and 3-dimensional echocardiography (coaxial scanning) with tissue harmonic imaging. Ten healthy subjects underwent estimation of LV volumes by transthoracic...

  19. [Educational intervention for the expression of cognitive excellence].

    Science.gov (United States)

    Sastre-Riba, Sylvia

    2015-02-25

    The aim of the study is a reflection on the current standing of giftedness research and the effectiveness of gifted education in order to facilitate its optimal developmental trajectory from potential to eminence. The necessity of rethinking high intellectual ability as a developmental process is exposed from a new paradigm sustained by research results that could lead us to a better understanding of its nature and functioning as the product of the inter-relation of predictor factors and psychosocial modulators across the development, and the participation of executive functions on cognitive management. Rethinking giftedness education is needed, too, in order to prepare young people for outstanding achievement or eminence. Finally, one of the actual effective models of intervention for gifted learners to excellence is exposed and exemplified: the integrated curriculum model.

  20. 国内外大型先进企业开放式创新的动因与模式%Motivations and Models of Open Innovation at Chinese and Overseas Large-scale Excellent Enterprises

    Institute of Scientific and Technical Information of China (English)

    袁磊; 杨虹; 何艳青

    2015-01-01

    Open innovation is the main model for enterprises’ technological creation in the knowledge-based economic era. Based on the study of Shell, Petrobras, GE and China’s Huawei, this paper analyzes motivations of enterprises’ open innovation including support of main business development, expansion of new businesses, access to target market, enhancement of technological capacity, promotion of industrial technological position, acceleration of research process, reduction of cost, and fulfillment of national and social responsibilities. The operational models include purchase of technological patents, acquisition of technology, government-industry-university-research collaboration, launch of joint industrial projects, and raising fund or providing support for external innovation activities. Open innovation should be in line with the industrial development and the enterprises’ strategic demand. Based on the efforts to improve its independent ability for innovation, the enterprise should make full use of various external resources, tighten control over intellectual property, adopt opener and more lfexible management pattern, and establish perfect information monitoring network.%开放式创新是知识经济时代企业技术创新的主要发展模式,研究了壳牌、巴西国家石油公司、GE和我国华为公司等具体实践,分析了企业开放式创新的动因主要包括支持主营业务发展、开拓新业务、进入目标市场、增强技术能力、提高行业技术地位、加快研发进程、降低成本和担当国家与社会责任等,运行模式多采取购买技术专利、技术并购、政产学研合作、组织联合工业项目、为外部创新活动融资或提供协助等,指出实施开放式创新需要符合行业特点和自身战略需求,要在依靠和提高自主创新能力的基础上充分利用各种外部资源,加强知识产权管理,采取更加开放、灵活的管理模式,建立完善的信息监测网络。