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Sample records for model proposed earlier

  1. Proposed reliability cost model

    Science.gov (United States)

    Delionback, L. M.

    1973-01-01

    The research investigations which were involved in the study include: cost analysis/allocation, reliability and product assurance, forecasting methodology, systems analysis, and model-building. This is a classic example of an interdisciplinary problem, since the model-building requirements include the need for understanding and communication between technical disciplines on one hand, and the financial/accounting skill categories on the other. The systems approach is utilized within this context to establish a clearer and more objective relationship between reliability assurance and the subcategories (or subelements) that provide, or reenforce, the reliability assurance for a system. Subcategories are further subdivided as illustrated by a tree diagram. The reliability assurance elements can be seen to be potential alternative strategies, or approaches, depending on the specific goals/objectives of the trade studies. The scope was limited to the establishment of a proposed reliability cost-model format. The model format/approach is dependent upon the use of a series of subsystem-oriented CER's and sometimes possible CTR's, in devising a suitable cost-effective policy.

  2. Proposed Reliability/Cost Model

    Science.gov (United States)

    Delionback, L. M.

    1982-01-01

    New technique estimates cost of improvement in reliability for complex system. Model format/approach is dependent upon use of subsystem cost-estimating relationships (CER's) in devising cost-effective policy. Proposed methodology should have application in broad range of engineering management decisions.

  3. The 'model omnitron' proposed experiment

    International Nuclear Information System (INIS)

    Sestero, A.

    1997-05-01

    The Model Omitron is a compact tokamak experiment which is designed by the Fusion Engineering Unit of ENEA and CITIF CONSORTIUM. The building of Model Omitron would allow for full testing of Omitron engineering, and partial testing of Omitron physics -at about 1/20 of the cost that has been estimated for the larger parent machine. In particular, due to the unusually large ohmic power densities (up to 100 times the nominal value in the Frascati FTU experiment), in Model Omitron the radial energy flux is reaching values comparable or higher than envisaged of the larger ignition experiments Omitron, Ignitor and Iter. Consequently, conditions are expected to occur at the plasma border in the scrape-off layer of Model Omitron, which are representative of the quoted larger experiments. Moreover, since all this will occur under ohmic heating alone, one will hopefully be able to derive an energy transport model fo the ohmic heating regime that is valid over a range of plasma parameters (in particular, of the temperature parameter) wider than it was possible before. In the Model Omitron experiment, finally - by reducing the plasma current and/or the toroidal field down to, say, 1/3 or 1/4 of the nominal values -additional topics can be tackled, such as: large safety-factor configurations (of interest for improving confinement), large aspect-ratio configurations (of interest for the investigation of advanced concepts in tokamaks), high beta (with RF heating -also of interest for the investigation of advanced concepts in tokamaks), long pulse discharges (of interest for demonstrating stationary conditions in the current profile)

  4. Women's Language Model: A Proposal.

    Science.gov (United States)

    Dumas, Bethany K.

    It is possible to think of women's language in terms of the model implied by the following statement. Insofar as native speakers of English are concerned, the language of women in America has four sets of components: those shared with the language of men in America; those shared, in varying proportions, with other women living in patriarchies;…

  5. Aerosol exposure to Rift Valley fever virus causes earlier and more severe neuropathology in the murine model, which has important implications for therapeutic development.

    Directory of Open Access Journals (Sweden)

    Christopher Reed

    Full Text Available Rift Valley fever virus (RVFV is an important mosquito-borne veterinary and human pathogen that can cause severe disease including acute-onset hepatitis, delayed-onset encephalitis, retinitis and blindness, or a hemorrhagic syndrome. Currently, no licensed vaccine or therapeutics exist to treat this potentially deadly disease. Detailed studies describing the pathogenesis of RVFV following aerosol exposure have not been completed and candidate therapeutics have not been evaluated following an aerosol exposure. These studies are important because while mosquito transmission is the primary means for human infection, it can also be transmitted by aerosol or through mucosal contact. Therefore, we directly compared the pathogenesis of RVFV following aerosol exposure to a subcutaneous (SC exposure in the murine model by analyzing survival, clinical observations, blood chemistry, hematology, immunohistochemistry, and virus titration of tissues. Additionally, we evaluated the effectiveness of the nucleoside analog ribavirin administered prophylactically to treat mice exposed by aerosol and SC. The route of exposure did not significantly affect the survival, chemistry or hematology results of the mice. Acute hepatitis occurred despite the route of exposure. However, the development of neuropathology occurred much earlier and was more severe in mice exposed by aerosol compared to SC exposed mice. Mice treated with ribavirin and exposed SC were partially protected, whereas treated mice exposed by aerosol were not protected. Early and aggressive viral invasion of brain tissues following aerosol exposure likely played an important role in ribavirin's failure to prevent mortality among these animals. Our results highlight the need for more candidate antivirals to treat RVFV infection, especially in the case of a potential aerosol exposure. Additionally, our study provides an account of the key pathogenetic differences in RVF disease following two potential

  6. Health benefits, costs, and cost-effectiveness of earlier eligibility for adult antiretroviral therapy and expanded treatment coverage: a combined analysis of 12 mathematical models.

    Science.gov (United States)

    Eaton, Jeffrey W; Menzies, Nicolas A; Stover, John; Cambiano, Valentina; Chindelevitch, Leonid; Cori, Anne; Hontelez, Jan A C; Humair, Salal; Kerr, Cliff C; Klein, Daniel J; Mishra, Sharmistha; Mitchell, Kate M; Nichols, Brooke E; Vickerman, Peter; Bakker, Roel; Bärnighausen, Till; Bershteyn, Anna; Bloom, David E; Boily, Marie-Claude; Chang, Stewart T; Cohen, Ted; Dodd, Peter J; Fraser, Christophe; Gopalappa, Chaitra; Lundgren, Jens; Martin, Natasha K; Mikkelsen, Evelinn; Mountain, Elisa; Pham, Quang D; Pickles, Michael; Phillips, Andrew; Platt, Lucy; Pretorius, Carel; Prudden, Holly J; Salomon, Joshua A; van de Vijver, David A M C; de Vlas, Sake J; Wagner, Bradley G; White, Richard G; Wilson, David P; Zhang, Lei; Blandford, John; Meyer-Rath, Gesine; Remme, Michelle; Revill, Paul; Sangrujee, Nalinee; Terris-Prestholt, Fern; Doherty, Meg; Shaffer, Nathan; Easterbrook, Philippa J; Hirnschall, Gottfried; Hallett, Timothy B

    2014-01-01

    New WHO guidelines recommend initiation of antiretroviral therapy for HIV-positive adults with CD4 counts of 500 cells per μL or less, a higher threshold than was previously recommended. Country decision makers have to decide whether to further expand eligibility for antiretroviral therapy accordingly. We aimed to assess the potential health benefits, costs, and cost-effectiveness of various eligibility criteria for adult antiretroviral therapy and expanded treatment coverage. We used several independent mathematical models in four settings-South Africa (generalised epidemic, moderate antiretroviral therapy coverage), Zambia (generalised epidemic, high antiretroviral therapy coverage), India (concentrated epidemic, moderate antiretroviral therapy coverage), and Vietnam (concentrated epidemic, low antiretroviral therapy coverage)-to assess the potential health benefits, costs, and cost-effectiveness of various eligibility criteria for adult antiretroviral therapy under scenarios of existing and expanded treatment coverage, with results projected over 20 years. Analyses assessed the extension of eligibility to include individuals with CD4 counts of 500 cells per μL or less, or all HIV-positive adults, compared with the previous (2010) recommendation of initiation with CD4 counts of 350 cells per μL or less. We assessed costs from a health-system perspective, and calculated the incremental cost (in US$) per disability-adjusted life-year (DALY) averted to compare competing strategies. Strategies were regarded very cost effective if the cost per DALY averted was less than the country's 2012 per-head gross domestic product (GDP; South Africa: $8040; Zambia: $1425; India: $1489; Vietnam: $1407) and cost effective if the cost per DALY averted was less than three times the per-head GDP. In South Africa, the cost per DALY averted of extending eligibility for antiretroviral therapy to adult patients with CD4 counts of 500 cells per μL or less ranged from $237 to $1691 per

  7. Proposal for an ecoradiological centre model

    International Nuclear Information System (INIS)

    Perovic, S.M.; Zunic, Z.; Demajo, M.; Konjevic, N.

    1998-01-01

    The problem of establishing an optimal Ecoradiological Centre Model is studied in some detail for the town of Kotor which is under the protection of the World Cultural and Natural Heritage. The proposed structure of the Centre is analyzed from the view of Engineering, Education and Scientific parameters. This Model is suitable for implementation as a network Centre Model for the state of Montenegro. Further, the modelling strategy of the ecoradiological condition control of natural, construction, bio and technological systems is elaborated. The proposal includes the ecoradiological monitoring, radioactive and electromagnetic radiation processing and protection for different natural zones as well as their different geostructures, aerial and hydrogeological conditions. The programme also includes all housing objects (hotels, flats, houses, office premises etc.). Here will also be presented the radiation protection and recommendations for the implementation of Title VII of the European Basic Safety Standards Directive (BSS), concerning significant increase in exposure due to natural radiation sources. Also, the proposal of Local Radiation Protection for the town of Kotor is presented. Our proposal for an Ecoradiological Centre Model presented here is in a form of a pilot programme, applicable also for other towns and states. (author)

  8. A proposed general model of information behaviour.

    Directory of Open Access Journals (Sweden)

    2003-01-01

    Full Text Available Presents a critical description of Wilson's (1996 global model of information behaviour and proposes major modification on the basis of research into information behaviour of managers, conducted in Poland. The theoretical analysis and research results suggest that Wilson's model has certain imperfections, both in its conceptual content, and in graphical presentation. The model, for example, cannot be used to describe managers' information behaviour, since managers basically are not the end users of external from organization or computerized information services, and they acquire information mainly through various intermediaries. Therefore, the model cannot be considered as a general model, applicable to every category of information users. The proposed new model encompasses the main concepts of Wilson's model, such as: person-in-context, three categories of intervening variables (individual, social and environmental, activating mechanisms, cyclic character of information behaviours, and the adoption of a multidisciplinary approach to explain them. However, the new model introduces several changes. They include: 1. identification of 'context' with the intervening variables; 2. immersion of the chain of information behaviour in the 'context', to indicate that the context variables influence behaviour at all stages of the process (identification of needs, looking for information, processing and using it; 3. stress is put on the fact that the activating mechanisms also can occur at all stages of the information acquisition process; 4. introduction of two basic strategies of looking for information: personally and/or using various intermediaries.

  9. A proposed experiment on ball lightning model

    International Nuclear Information System (INIS)

    Ignatovich, Vladimir K.; Ignatovich, Filipp V.

    2011-01-01

    Highlights: → We propose to put a glass sphere inside an excited gas. → Then to put a light ray inside the glass in a whispering gallery mode. → If the light is resonant to gas excitation, it will be amplified at every reflection. → In ms time the light in the glass will be amplified, and will melt the glass. → A liquid shell kept integer by electrostriction forces is the ball lightning model. -- Abstract: We propose an experiment for strong light amplification at multiple total reflections from active gaseous media.

  10. Media Accountability Systems: Models, proposals and outlooks

    Directory of Open Access Journals (Sweden)

    Luiz Martins da Silva

    2007-06-01

    Full Text Available This paper analyzes one of the basic actions of SOS-Imprensa, the mechanism to assure Media Accountability with the goal of proposing a synthesis of models for the Brazilian reality. The article aims to address the possibilities of creating and improving mechanisms to stimulate the democratic press process and to mark out and assure freedom of speech and personal rights with respect to the media. Based on the Press Social Responsibility Theory, the hypothesis is that the experiences analyzed (Communication Council, Press Council, Ombudsman and Readers Council are alternatives for accountability, mediation and arbitration, seeking visibility, trust and public support in favor of fairer media.

  11. A Proposed Conceptual Model of Military Medical Readiness

    National Research Council Canada - National Science Library

    Van Hall, Brian M

    2007-01-01

    .... The basis for the proposed conceptual model builds on common and accepted latent variable and theoretical modeling techniques proposed by healthcare scholars, organizational theorists, mathematical...

  12. The 'OMITRON' and 'MODEL OMITRON' proposed experiments

    International Nuclear Information System (INIS)

    Sestero, A.

    1997-12-01

    In the present paper the main features of the OMITRON and MODEL OMITRON proposed high field tokamaks are illustrated. Of the two, OMITRON is an ambitious experiment, aimed at attaining plasma burning conditions. its key physics issues are discussed, and a comparison is carried out with corresponding physics features in ignition experiments such as IGNITOR and ITER. Chief asset and chief challenge - in both OMITRON and MODEL OMITRON is the conspicuous 20 Tesla toroidal field value on the plasma axis. The advanced features of engineering which consent such a reward in terms of toroidal magnet performance are discussed in convenient depth and detail. As for the small, propaedeutic device MODEL OMITRON among its goals one must rank the purpose of testing key engineering issues in vivo, which are vital for the larger and more expensive parent device. Besides that, however - as indicated by ad hoc performed scoping studies - the smaller machine is found capable also of a number of quite interesting physics investigations in its own right

  13. Estimating the Impact of Earlier ART Initiation and Increased Testing Coverage on HIV Transmission among Men Who Have Sex with Men in Mexico using a Mathematical Model.

    Science.gov (United States)

    Caro-Vega, Yanink; del Rio, Carlos; Lima, Viviane Dias; Lopez-Cervantes, Malaquias; Crabtree-Ramirez, Brenda; Bautista-Arredondo, Sergio; Colchero, M Arantxa; Sierra-Madero, Juan

    2015-01-01

    To estimate the impact of late ART initiation on HIV transmission among men who have sex with men (MSM) in Mexico. An HIV transmission model was built to estimate the number of infections transmitted by HIV-infected men who have sex with men (MSM-HIV+) MSM-HIV+ in the short and long term. Sexual risk behavior data were estimated from a nationwide study of MSM. CD4+ counts at ART initiation from a representative national cohort were used to estimate time since infection. Number of MSM-HIV+ on treatment and suppressed were estimated from surveillance and government reports. Status quo scenario (SQ), and scenarios of early ART initiation and increased HIV testing were modeled. We estimated 14239 new HIV infections per year from MSM-HIV+ in Mexico. In SQ, MSM take an average 7.4 years since infection to initiate treatment with a median CD4+ count of 148 cells/mm3(25th-75th percentiles 52-266). In SQ, 68% of MSM-HIV+ are not aware of their HIV status and transmit 78% of new infections. Increasing the CD4+ count at ART initiation to 350 cells/mm3 shortened the time since infection to 2.8 years. Increasing HIV testing to cover 80% of undiagnosed MSM resulted in a reduction of 70% in new infections in 20 years. Initiating ART at 500 cells/mm3 and increasing HIV testing the reduction would be of 75% in 20 years. A substantial number of new HIV infections in Mexico are transmitted by undiagnosed and untreated MSM-HIV+. An aggressive increase in HIV testing coverage and initiating ART at a CD4 count of 500 cells/mm3 in this population would significantly benefit individuals and decrease the number of new HIV infections in Mexico.

  14. Child-Labor Proposal Eyes Private Model

    Science.gov (United States)

    Cech, Scott J.

    2007-01-01

    Proposed child-labor-rule changes--the most ambitious in 30 years--would carve out a permanent exemption to U.S. Department of Labor regulations for the work-study program run by a national network of Roman Catholic high schools. The program is a requirement of the Chicago-based Cristo Rey Network, which now has 12 high schools around the country…

  15. A Proposed Curriculum Model for Geriatric Optometry.

    Science.gov (United States)

    Rosenbloom, Albert A.

    1985-01-01

    A model for a geriatric optometry curriculum that defines key content areas and addresses the values essential for effective practice and basic therapeutic modalities used in treatment regimens with older adults is outlined. (MSE)

  16. A proposed model for construction project management ...

    African Journals Online (AJOL)

    Keywords: Communication skills and leadership model, construction project ..... help a manager handle stress and break tension (Gido & Clements,. 2012: 331; Harrin .... production and management of projects, the higher the demand for.

  17. A proposed model for construction project management ...

    African Journals Online (AJOL)

    Log in or Register to get access to full text downloads. ... (decision-making, problem-solving, listening, verbal competency, motivation, persuasion, ... Keywords: Communication skills and leadership model, construction project management, ...

  18. Alzheimer's and Dementia Testing for Earlier Diagnosis

    Science.gov (United States)

    ... for Earlier Diagnosis What if we could diagnose Alzheimer's before symptoms started? The hope is, future treatments ... diagnosis is among the most active areas in Alzheimer's science, and funding from the Alzheimer's Association has ...

  19. A Proposal for a Flexible Trend Specification in DSGE Models

    Directory of Open Access Journals (Sweden)

    Slanicay Martin

    2016-06-01

    Full Text Available In this paper I propose a flexible trend specification for estimating DSGE models on log differences. I demonstrate this flexible trend specification on a New Keynesian DSGE model of two economies, which I consequently estimate on data from the Czech economy and the euro area, using Bayesian techniques. The advantage of the trend specification proposed is that the trend component and the cyclical component are modelled jointly in a single model. The proposed trend specification is flexible in the sense that smoothness of the trend can be easily modified by different calibration of some of the trend parameters. The results suggest that this method is capable of finding a very reasonable trend in the data. Moreover, comparison of forecast performance reveals that the proposed specification offers more reliable forecasts than the original variant of the model.

  20. A Proposed Systems Model for Socializing the Graduate Writer

    Science.gov (United States)

    Jones, David R.

    2018-01-01

    Although researchers chorus the need to support graduate students toward higher levels of writing proficiency, their findings lack a holistic model for doing so. A model emerges upon scrutiny of the factors that have been implicated in supporting writing proficiency. In the proposed model, a socialization theory fits as a proximal process into the…

  1. A proposed best practice model validation framework for banks

    Directory of Open Access Journals (Sweden)

    Pieter J. (Riaan de Jongh

    2017-06-01

    Full Text Available Background: With the increasing use of complex quantitative models in applications throughout the financial world, model risk has become a major concern. The credit crisis of 2008–2009 provoked added concern about the use of models in finance. Measuring and managing model risk has subsequently come under scrutiny from regulators, supervisors, banks and other financial institutions. Regulatory guidance indicates that meticulous monitoring of all phases of model development and implementation is required to mitigate this risk. Considerable resources must be mobilised for this purpose. The exercise must embrace model development, assembly, implementation, validation and effective governance. Setting: Model validation practices are generally patchy, disparate and sometimes contradictory, and although the Basel Accord and some regulatory authorities have attempted to establish guiding principles, no definite set of global standards exists. Aim: Assessing the available literature for the best validation practices. Methods: This comprehensive literature study provided a background to the complexities of effective model management and focussed on model validation as a component of model risk management. Results: We propose a coherent ‘best practice’ framework for model validation. Scorecard tools are also presented to evaluate if the proposed best practice model validation framework has been adequately assembled and implemented. Conclusion: The proposed best practice model validation framework is designed to assist firms in the construction of an effective, robust and fully compliant model validation programme and comprises three principal elements: model validation governance, policy and process.

  2. A Proposed Conceptual Model of Military Medical Readiness

    National Research Council Canada - National Science Library

    Van Hall, Brian M

    2007-01-01

    .... The purpose of this research is to consolidate existing literature on the latent variable of medical readiness, and to propose a composite theoretical model of medical readiness that may provide...

  3. Linear regression crash prediction models : issues and proposed solutions.

    Science.gov (United States)

    2010-05-01

    The paper develops a linear regression model approach that can be applied to : crash data to predict vehicle crashes. The proposed approach involves novice data aggregation : to satisfy linear regression assumptions; namely error structure normality ...

  4. Gamification in online education: proposal for a participatory learning model

    Directory of Open Access Journals (Sweden)

    Fabiana Bigão Silva

    2017-09-01

    Full Text Available Empirical studies have suggested limitations on the form of application of gamification mechanics in the context of online education. These mechanics have been applied without reference to a theoretical model dedicated to this type of education. The objective of the paper is to propose a model for a gamified platform for online education that contributes to a more participatory learning, taking into account the different student profiles. Based on literature review about approaches to gamification systems design, a set of steps was followed in order to develop a generic model for a framework dedicated to online education. The model proposed is based on the Educational Gamification Design Principles proposed by Dicheva et al. (2015. The model may contribute to the promotion of participatory learning, taking into account the different student profiles. The results of such evaluation will be published in the future.

  5. A Modified Microfinance Model Proposed for the United States

    Directory of Open Access Journals (Sweden)

    Eldon H Bernstein

    2014-07-01

    While the goal in the traditional model in developing markets is the elimination of poverty, we show how those critical conditions help to explain the lack of success in the United States.  We propose a modified model whose goal is the creation of an entrepreneurial venture or improving the performance of an existing small enterprise.

  6. Proposal for product development model focused on ce certification methodology

    Directory of Open Access Journals (Sweden)

    Nathalia Marcia Goulart Pinheiro

    2015-09-01

    Full Text Available This paper presents a critical analysis comparing 21 product development models in order to identify whether these structures meet the demands Product Certification of the European Community (CE. Furthermore, it presents a product development model, comprising the steps in the models analyzed, including improvements in activities for referred product certification. The proposed improvements are justified by the growing quest for the internationalization of products and processes within companies.

  7. A proposed residual stress model for oblique turning

    International Nuclear Information System (INIS)

    Elkhabeery, M. M.

    2001-01-01

    A proposed mathematical model is presented for predicting the residual stresses caused by turning. Effects of change in tool free length, cutting speed, feed rate, and the tensile strength of work piece material on the maximum residual stress are investigated. The residual stress distribution in the surface region due to turning under unlubricated condition is determined using a deflection etching technique. To reduce the number of experiments required and build the mathematical model for these variables, Response Surface Methodology (RSM) is used. In addition, variance analysis and an experimental check are conducted to determine the prominent parameters and the adequacy of the model. The results show that the tensile stress of the work piece material, cutting speed, and feed rate have significant effects on the maximum residual stresses. The proposed model, that offering good correlation between the experimental and predicted results, is useful in selecting suitable cutting parameters for the machining of different materials. (author)

  8. Main features of the proposed NCRP respiratory tract model

    International Nuclear Information System (INIS)

    Phalen, R.F.; Fisher, G.L.; Moss, O.R.; Schlesinger, R.B.; Swift, D.L.

    1991-01-01

    The proposed NCRP respiratory tract dosimetry model regions include the naso-oro-pharyngo-laryngeal (NOPL), the tracheobronchial (TB), the pulmonary (P), and the lymph nodes (LN). Input aerosol concentrations are derived from a consideration of particle-size-dependent inspirability. Particle deposition in the respiratory tract is modelled using the mechanisms of inertial impaction, sedimentation and diffusion. The rates of absorption of particles, and transport to the blood, have been derived from clearance data from people and laboratory animals. The effect of body growth on particle deposition is considered. Particle clearance rates are assumed to be independent of age. The proposed respiratory tract model differs significantly from the 1966 Task Group Model in that (1) inspirability is considered; (2) new sub-regions of the respiratory tract are considered; (3) absorption of materials by the blood is treated in a more sophisticated fashion; and (4) body size (and thus age) is taken into account. (author)

  9. Proposed higher order continuum-based models for an elastic ...

    African Journals Online (AJOL)

    Three new variants of continuum-based models for an elastic subgrade are proposed. The subgrade is idealized as a homogenous, isotropic elastic layer of thickness H overlying a firm stratum. All components of the stress tensor in the subgrade are taken into account. Reasonable assumptions are made regarding the ...

  10. A Proposed Model of Jazz Theory Knowledge Acquisition

    Science.gov (United States)

    Ciorba, Charles R.; Russell, Brian E.

    2014-01-01

    The purpose of this study was to test a hypothesized model that proposes a causal relationship between motivation and academic achievement on the acquisition of jazz theory knowledge. A reliability analysis of the latent variables ranged from 0.92 to 0.94. Confirmatory factor analyses of the motivation (standardized root mean square residual…

  11. Proposal of a theoretical model for the practical nurse

    Directory of Open Access Journals (Sweden)

    Dolores Abril Sabater

    2010-01-01

    Full Text Available AIM: To determine which model of nursing is proposed by care professionals and the reason for their choice. METHOD: cross-sectional, descriptive study design. The main variable: Nursing Models and Theories. As secondary variables were collected: age, gender, years of work experience, nursing model of basic training, and course/s related. We used a self-elaborated, anonymous questionnaire, passed between April - May, 2006. Not random sample.RESULTS: 546 nurses were invited, answered 205. 38 % response rate. Virginia Henderson was the more selected model (33%, however, 42% left the question blank, 12% indicated that they wanted to work under the guidance of a model. They selected a specifically model: Knowledge of the model to their training, standardization in other centers, the characteristics of the model itself and identification with its philosophy. They are not decided by a model by ignorance, lack of time and usefulness. CONCLUSIONS: The model chosen mostly for their daily work was Virginia Henderson model, so that knowledge of a model is the main reason for their election. Professionals who choose not to use the model in their practice realize offers and calling for resources, besides to explain the lack of knowledge on this topic. To advance the nursing profession is necessary that nurse is thought over widely on the abstract concepts of the theory in our context.

  12. Bayesian inference of chemical kinetic models from proposed reactions

    KAUST Repository

    Galagali, Nikhil

    2015-02-01

    © 2014 Elsevier Ltd. Bayesian inference provides a natural framework for combining experimental data with prior knowledge to develop chemical kinetic models and quantify the associated uncertainties, not only in parameter values but also in model structure. Most existing applications of Bayesian model selection methods to chemical kinetics have been limited to comparisons among a small set of models, however. The significant computational cost of evaluating posterior model probabilities renders traditional Bayesian methods infeasible when the model space becomes large. We present a new framework for tractable Bayesian model inference and uncertainty quantification using a large number of systematically generated model hypotheses. The approach involves imposing point-mass mixture priors over rate constants and exploring the resulting posterior distribution using an adaptive Markov chain Monte Carlo method. The posterior samples are used to identify plausible models, to quantify rate constant uncertainties, and to extract key diagnostic information about model structure-such as the reactions and operating pathways most strongly supported by the data. We provide numerical demonstrations of the proposed framework by inferring kinetic models for catalytic steam and dry reforming of methane using available experimental data.

  13. Tacit knowledge in academia: a proposed model and measurement scale.

    Science.gov (United States)

    Leonard, Nancy; Insch, Gary S

    2005-11-01

    The authors propose a multidimensional model of tacit knowledge and develop a measure of tacit knowledge in academia. They discuss the theory and extant literature on tacit knowledge and propose a 6-factor model. Experiment 1 is a replication of a recent study of academic tacit knowledge using the scale developed and administered at an Israeli university (A. Somech & R. Bogler, 1999). The results of the replication differed from those found in the original study. For Experiment 2, the authors developed a domain-specific measure of academic tacit knowledge, the Academic Tacit Knowledge Scale (ATKS), and used this measure to explore the multidimensionality of tacit knowledge proposed in the model. The results of an exploratory factor analysis (n=142) followed by a confirmatory factor analysis (n=286) are reported. The sample for both experiments was 428 undergraduate students enrolled at a large public university in the eastern United States. Results indicated that a 5-factor model of academic tacit knowledge provided a strong fit for the data.

  14. Proposal of a new biokinetic model for niobium

    International Nuclear Information System (INIS)

    Oliveira, Roges

    2006-01-01

    There are two niobium isotopes generated in nuclear power plants: 95 Nb and 94 Nb. Workers and members of the public are subjects to intake these radionuclides in accident situation. For dose calculation purpose, it is very important to develop a model that describes in a more realistic way the kinetics of niobium inside of the human body. Presently the model adopted by ICRP (ICRP, 1989) is based on animal studies and describes the behavior of niobium in human being in a simple manner. The new model proposal describes the kinetics of the niobium from the intake into the blood until the excretion, doing this in a more realistic form and considering not only data from animals but data from human beings as well. For this objective, a workers group of a niobium extraction and processing industry exposed to stable niobium (93 Nb) in oxide insoluble form with associated uranium, was monitored for uranium and niobium determination in urinary and fecal excretion, by mass spectrometry. Based in the ratios of the niobium concentration in urinary and faecal excretion of this workers and animal data study, a new biokinetic model for niobium was proposed, with the followings modifications relative to ICRP model: a new compartment that represents muscular tissue; the fractions which are deposited into the compartment are modified; a third component in the retention equation of the bone tissue; introduction of recirculation between organs and blood. The new model was applied for a case of accidental intake and described adequately the experimental data

  15. The Associative Basis of Scientific Creativity: A Model Proposal

    Directory of Open Access Journals (Sweden)

    Esra Kanli

    2014-06-01

    Full Text Available Creativity is accepted as an important part of scientific skills. Scientific creativity proceeds from a need or urge to solve a problem, and in-volves the production of original and useful ideas or products. Existing scientific creativity theories and tests do not feature the very im-portant thinking processes, such as analogical and associative thinking, which can be consid-ered crucial in creative scientific problem solv-ing. Current study’s aim is to provide an alter-native model and explicate the associative basis of scientific creativity. Emerging from the re-viewed theoretical framework, Scientific Asso-ciations Model is proposed. This model claims that, similarity and mediation constitutes the basis of creativity and focuses on three compo-nents namely; associative thinking, analogical thinking (analogical reasoning & analogical problem solving and insight which are consid-ered to be main elements of scientific associa-tive thinking.

  16. PROPOSAL OF A MODEL MANAGEMENT TO SMALL DESIGN COMPANIES

    Directory of Open Access Journals (Sweden)

    Otávio José de OLIVEIRA

    2008-11-01

    Full Text Available The main purpose of this paper is the proposition of a management model specifically developed for small building design firms, aligned with their needs and particularities. The field research was conducted with a qualitative approach through the analysis of four case studies in small building design firms acting mainly in São Paulo City. The data collection was accomplished through semi-structured interviews, direct observation and analysis of documents. The proposed model includes guidance to the management of the core processes and activities of small building design firms, such as: organizational structure; strategic planning; planning and control of design process; costs management; sales management; information systems; human resources management; services added to the design; and performance evaluation. Key-words: design firms; design process; building construction.

  17. Patent portfolio management: literature review and a proposed model.

    Science.gov (United States)

    Conegundes De Jesus, Camila Kiyomi; Salerno, Mario Sergio

    2018-05-09

    Patents and patent portfolios are gaining attention in the last decades, from the called 'pro-patent era' to the recent billionaire transactions involving patent portfolios. The field is growing in importance, both theoretically and practically and despite having substantial literature on new product development portfolio management, we have not found an article relating this theory to patent portfolios. Areas covered: The paper develops a systematic literature review on patent portfolio management to organize the evolution and tendencies of patent portfolio management, highlighting distinctive features of patent portfolio management. Interview with IP manager of three life sciences companies, including a leading multinational group provided relevant information about patent portfolio management. Expert opinion: Based on the systematic literature review on portfolio management, more specifically, on new product development portfolio theory, and interview the paper proposes the paper proposes a reference model to manage patent portfolios. The model comprises four stages aligned with the three goals of the NPD portfolio management: 1 - Linking strategy of the Company's NPD Portfolio to Patent Portfolio; 2 - Balancing the portfolio in buckets; 3 - Patent Valuation (maximizing valuation); 4 - Regularly reviewing the patent portfolio.

  18. The evaluation of doctoral thesis. A model proposal

    Directory of Open Access Journals (Sweden)

    de-Miguel, Mario

    2010-04-01

    Full Text Available The aim of this work is the development of a model that can be used as a framework for evaluators and PhD tribunal members, either during the previous administrative processing phase or at the actual exposition and viva on doctoral dissertations. To this end, once reviewed the existing literature and normative, a new proposal is laid out on the main aspects and criteria to be analysed and assessed from any given scientific work, thus introducing a tool that facilitates and specifies this work. Our model is intended to be an open proposal on which we would welcome any contribution and suggestion. El objetivo del presente trabajo es la elaboración de un modelo que pueda ser utilizado como marco de referencia por los evaluadores y miembros de tribunales de las tesis doctorales tanto en la fase previa a la tramitación administrativa como en el acto de exposición y defensa de la misma. Para ello, una vez revisada la literatura y la normativa vigente al respecto, efectuamos una propuesta sobre los principales aspectos y criterios que deben ser objeto de análisis y valoración en todo trabajo científico, y presentamos una herramienta que facilita y precisa esta tarea. Nuestro modelo constituye una propuesta abierta sobre la que esperamos aportaciones y sugerencias.

  19. "The Actualized Neurosurgeon": A Proposed Model of Surgical Resident Development.

    Science.gov (United States)

    Lipsman, Nir; Khan, Osaama; Kulkarni, Abhaya V

    2017-03-01

    Modern neurosurgical training is both physically and emotionally demanding, posing significant challenges, new and old, to residents as well as programs attempting to train safe, competent surgeons. Models to describe resident development, such as the Accreditation Council for Graduate Medical Education competencies and milestones, address the acquisition of specific skills but largely ignore the stresses and pressures unique to each stage of resident training. We propose an alternative model of resident development adapted from the developmental psychology literature. Our model identifies the challenges that must be met at each stage of junior, intermediate, and senior and chief residency, leading ultimately to an "actualized" neurosurgeon (i.e., one who has maximized his or her potential). Failure to overcome any 1 of these challenges can lead to specific long-lasting consequences, including regret, identity crisis, incompetence, and bitterness. In contrast, the actualized surgeon is one who has successfully acquired the virtues of hope, will, purpose, fidelity, productivity, leadership, competence, and wisdom. The actualized surgeon not only functions safely, confidently, and professionally, but also successfully navigates the challenges of residency and emerges from them having fulfilled his or her maximal potential. This developmental perspective provides an individualized description of healthy surgical development. Our model allows programs to identify the basis for residents who fail to progress, counsel residents during their training, and perhaps help identify resident candidates who are better prepared to meet the developmental challenges of residency training. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Modeling Instruction of David Hestenes: a proposal of thematic modeling cycle and discussion of scientific literacy

    Directory of Open Access Journals (Sweden)

    Ednilson Sergio Ramalho de Souza

    2016-07-01

    Full Text Available The pedagogical work with mathematical modeling assumes investigate situations of reality. However, mental models formed from the contact with the experiential world are generally incompatible with the conceptual models. So David Hestenes supports the view that one of the biggest challenges of teaching and learning in science and mathematics is to coordinate conceptual models with mental models, which led to the elaboration of a didactic in mathematical modeling: Modeling Instruction. Our goal is to present a proposal for thematic modeling cycle drawn up in hestenesianos assumptions and discuss possibilities for scientific literacy. The main question was to know how to emerge indicators for scientific literacy for the proposed cycle. This is a bibliographic research in order to identify the available literature contributions on the subject and raise the possibility and challenges for the brazilian teaching science and mathematics. Preliminary results indicate that the proposed modeling cycle can develop indicators for scientific literacy of different natures.

  1. Proposal of a pedagogical model for mathematics teacher education

    Directory of Open Access Journals (Sweden)

    Alfonso Jiménez Espinosa

    2011-01-01

    Full Text Available This research-based article reflects on mathematics teacher education, and proposes a pedagogical model for this purpose, called Gradual Research Pedagogical Model (MPGI. This model considers the central curricular elements of any academic education process: student, teacher and contents, with evaluation as transversal element for analysis and feedback. The training of future teachers is constituted by three moments, each with its specific emphasis: the first is “contextualization”, which aims at having the student understand his or her new academic role, and identify and overcome his or her academic weak points, the second is “knowledge foundation”, which offers basic education in the fields of mathematics and pedagogy, as well as sensibilization towards social issues, opening up the student’s possibilities as leader and agent of change, and lastly, “knowledge immersion”, which is centered on research and the identification and study of topics and problems of the mathematical discipline as well as the pedagogical field.

  2. Databases for highway inventories. Proposal for a new model

    Energy Technology Data Exchange (ETDEWEB)

    Perez Casan, J.A.

    2016-07-01

    Database models for highway inventories are based on classical schemes for relational databases: many related tables, in which the database designer establishes, a priori, every detail that they consider relevant for inventory management. This kind of database presents several problems. First, adapting the model and its applications when new database features appear is difficult. In addition, the different needs of different sets of road inventory users are difficult to fulfil with these schemes. For example, maintenance management services, road authorities and emergency services have different needs. In addition, this kind of database cannot be adapted to new scenarios, such as other countries and regions (that may classify roads or name certain elements differently). The problem is more complex if the language used in these scenarios is not the same as that used in the database design. In addition, technicians need a long time to learn to use the database efficiently. This paper proposes a flexible, multilanguage and multipurpose database model, which gives an effective and simple solution to the aforementioned problems. (Author)

  3. Corporate Social Responsibility And Islamic Business Organizations: A Proposed Model

    Directory of Open Access Journals (Sweden)

    Rusnah Muhamad

    2008-01-01

    Full Text Available The issue of corporate social responsibility (CSR has been of growing concern among business communities in recent years. Various corporate leaders maintain that business is considered to contribute fully to the society if it is effi cient, profi table and socially responsible. Islam is considered as addin (a way of life, thus, providing comprehensive guidelines in every aspects of the believers’ life. It is the aim of this paper to propose an Islamic model of corporate social responsibility based on human relationships with the God (hablun min’Allah; with other fellow human being (hablun min’an-nas and with the environment.Keywords : Corporate Social Responsibility, Islamic Business Organization

  4. Methodology Using MELCOR Code to Model Proposed Hazard Scenario

    Energy Technology Data Exchange (ETDEWEB)

    Gavin Hawkley

    2010-07-01

    This study demonstrates a methodology for using the MELCOR code to model a proposed hazard scenario within a building containing radioactive powder, and the subsequent evaluation of a leak path factor (LPF) (or the amount of respirable material which that escapes a facility into the outside environment), implicit in the scenario. This LPF evaluation will analyzes the basis and applicability of an assumed standard multiplication of 0.5 × 0.5 (in which 0.5 represents the amount of material assumed to leave one area and enter another), for calculating an LPF value. The outside release is dependsent upon the ventilation/filtration system, both filtered and un-filtered, and from other pathways from the building, such as doorways (, both open and closed). This study is presents ed to show how the multiple leak path factorsLPFs from the interior building can be evaluated in a combinatory process in which a total leak path factorLPF is calculated, thus addressing the assumed multiplication, and allowing for the designation and assessment of a respirable source term (ST) for later consequence analysis, in which: the propagation of material released into the environmental atmosphere can be modeled and the dose received by a receptor placed downwind can be estimated and the distance adjusted to maintains such exposures as low as reasonably achievableALARA.. Also, this study will briefly addresses particle characteristics thatwhich affect atmospheric particle dispersion, and compares this dispersion with leak path factorLPF methodology.

  5. QAM: PROPOSED MODEL FOR QUALITY ASSURANCE IN CBSS

    Directory of Open Access Journals (Sweden)

    Latika Kharb

    2015-08-01

    Full Text Available Component-based software engineering (CBSE / Component-Based Development (CBD lays emphasis on decomposition of the engineered systems into functional or logical components with well-defined interfaces used for communication across the components. Component-based software development approach is based on the idea to develop software systems by selecting appropriate off-the-shelf components and then to assemble them with a well-defined software architecture. Because the new software development paradigm is much different from the traditional approach, quality assurance for component-based software development is a new topic in the software engineering research community. Because component-based software systems are developed on an underlying process different from that of the traditional software, their quality assurance model should address both the process of components and the process of the overall system. Quality assurance for component-based software systems during the life cycle is used to analyze the components for achievement of high quality component-based software systems. Although some Quality assurance techniques and component based approach to software engineering have been studied, there is still no clear and well-defined standard or guidelines for component-based software systems. Therefore, identification of the quality assurance characteristics, quality assurance models, quality assurance tools and quality assurance metrics, are under urgent need. As a major contribution in this paper, I have proposed QAM: Quality Assurance Model for component-based software development, which covers component requirement analysis, component development, component certification, component architecture design, integration, testing, and maintenance.

  6. Assimilating the Future for Better Forecasts and Earlier Warnings

    Science.gov (United States)

    Du, H.; Wheatcroft, E.; Smith, L. A.

    2016-12-01

    Multi-model ensembles have become popular tools to account for some of the uncertainty due to model inadequacy in weather and climate simulation-based predictions. The current multi-model forecasts focus on combining single model ensemble forecasts by means of statistical post-processing. Assuming each model is developed independently or with different primary target variables, each is likely to contain different dynamical strengths and weaknesses. Using statistical post-processing, such information is only carried by the simulations under a single model ensemble: no advantage is taken to influence simulations under the other models. A novel methodology, named Multi-model Cross Pollination in Time, is proposed for multi-model ensemble scheme with the aim of integrating the dynamical information regarding the future from each individual model operationally. The proposed approach generates model states in time via applying data assimilation scheme(s) to yield truly "multi-model trajectories". It is demonstrated to outperform traditional statistical post-processing in the 40-dimensional Lorenz96 flow. Data assimilation approaches are originally designed to improve state estimation from the past to the current time. The aim of this talk is to introduce a framework that uses data assimilation to improve model forecasts at future time (not to argue for any one particular data assimilation scheme). Illustration of applying data assimilation "in the future" to provide early warning of future high-impact events is also presented.

  7. A Proposed Model for Protein Crystal Nucleation and Growth

    Science.gov (United States)

    Pusey, Marc; Curreri, Peter A. (Technical Monitor)

    2002-01-01

    How does one take a molecule, strongly asymmetric in both shape and charge distribution, and assemble it into a crystal? We propose a model for the nucleation and crystal growth process for tetragonal lysozyme, based upon fluorescence, light, neutron, and X-ray scattering data, size exclusion chromatography experiments, dialysis kinetics, AFM, and modeling of growth rate data, from this and other laboratories. The first species formed is postulated to be a 'head to side' dimer. Through repeating associations involving the same intermolecular interactions this grows to a 4(sub 3) helix structure, that in turn serves as the basic unit for nucleation and subsequent crystal growth. High salt attenuates surface charges while promoting hydrophobic interactions. Symmetry facilitates subsequent helix-helix self-association. Assembly stability is enhanced when a four helix structure is obtained, with each bound to two neighbors. Only two unique interactions are required. The first are those for helix formation, where the dominant interaction is the intermolecular bridging anion. The second is the anti-parallel side-by-side helix-helix interaction, guided by alternating pairs of symmetry related salt bridges along each side. At this stage all eight unique positions of the P4(sub3)2(sub 1),2(sub 1) unit cell are filled. The process is one of a) attenuating the most strongly interacting groups, such that b) the molecules begin to self-associate in defined patterns, so that c) symmetry is obtained, which d) propagates as a growing crystal. Simple and conceptually obvious in hindsight, this tells much about what we are empirically doing when we crystallize macromolecules. By adjusting the growth parameters we are empirically balancing the intermolecular interactions, preferentially attenuating the dominant strong (for lysozyme the charged groups) while strengthening the lesser strong (hydrophobic) interactions. In the general case for proteins the lack of a singularly defined

  8. Neutronic characteristics of coupled moderator proposed in integrated model

    International Nuclear Information System (INIS)

    Teshigawara, Makoto; Meigo, Shin-ichiro; Sakata, Hideaki; Kai, Tetsuya; Harada, Masahide; Ikeda, Yujiro; Watanabe, Noboru

    2001-05-01

    A pulsed spallation source for the materials science and the life science is currently developing for its construction in the High Intensity Proton Accelerator Project proposed jointly by the Japan Atomic Energy Research Institute (JAERI) and the High Energy Accelerator Research Organization (KEK). This report presents the analytical results of the neutronic characteristics of the coupled moderator based on the analytical results obtained by using an integrated model which has established on the extensive neutronic and technical study. Total heat deposition in a hydrogen (H 2 ) moderator working as the main moderator was about 420 W/MW. Maximum nuclear heat density in the H 2 moderator was about 1 W/cm 3 /MW. Also total heat deposition in a premoderator was about 9.2 kW/MW. The heat density of the premoderator was comparable to that of the moderator vessel made of aluminum alloy. The heat density of the premoderator and the moderator vessel is about 1.2-2 times higher than that of the hydrogen moderator. The temperature from 300 K to 400 K of the premoderator did not affect on neutron intensity of the H 2 moderator. This suggested an engineering advantage on the thermal and hydraulic design. 6000 or 7000 type of a aluminum alloy was considered from the viewpoint of the neutron beam transmission. The proton beams scattered by the proton beam window did not affect on the nuclear heating in the H 2 moderator. The heat deposition in the H 2 moderator and the neutron intensity of the H 2 moderator did not depend on the proton beam profile but it did on the distance between the proton beam and the moderator. (author)

  9. A New Method of Earlier Kick Assessment Using ANFIS

    Directory of Open Access Journals (Sweden)

    Fatemeh Deregeh

    2013-01-01

    Full Text Available The late detection of the kick (the entrance of underground fluids into oil wells leads to oil well blowouts. It causes human life loss and imposes a great deal of expenses on the petroleum industry. This paper presents the application of adaptive neuro-fuzzy inference system designed for an earlier kick detection using measurable drilling parameters. In order to generate the initial fuzzy inference system, subtractive clustering is utilized. The training set contains 50 data samples and there are 362 data samples for testing the proposed method. Also, ANFIS structure is examined at different radii (the parameter of subtractive clustering. Different conformations are tested to get the earliest detection and the lowest false alarms while facing kick. Eventually, ANFIS verifies the danger exposure depth of about 28.6 meters before the depth that the kick was sensed by crew. Such an assessment gives the rig crew enough time to prepare for the danger and stop the operation before being exposed to high pressure zones.

  10. Identified research directions for using manufacturing knowledge earlier in the product lifecycle.

    Science.gov (United States)

    Hedberg, Thomas D; Hartman, Nathan W; Rosche, Phil; Fischer, Kevin

    2017-01-01

    Design for Manufacturing (DFM), especially the use of manufacturing knowledge to support design decisions, has received attention in the academic domain. However, industry practice has not been studied enough to provide solutions that are mature for industry. The current state of the art for DFM is often rule-based functionality within Computer-Aided Design (CAD) systems that enforce specific design requirements. That rule-based functionality may or may not dynamically affect geometry definition. And, if rule-based functionality exists in the CAD system, it is typically a customization on a case-by-case basis. Manufacturing knowledge is a phrase with vast meanings, which may include knowledge on the effects of material properties decisions, machine and process capabilities, or understanding the unintended consequences of design decisions on manufacturing. One of the DFM questions to answer is how can manufacturing knowledge, depending on its definition, be used earlier in the product lifecycle to enable a more collaborative development environment? This paper will discuss the results of a workshop on manufacturing knowledge that highlights several research questions needing more study. This paper proposes recommendations for investigating the relationship of manufacturing knowledge with shape, behavior, and context characteristics of product to produce a better understanding of what knowledge is most important. In addition, the proposal includes recommendations for investigating the system-level barriers to reusing manufacturing knowledge and how model-based manufacturing may ease the burden of knowledge sharing. Lastly, the proposal addresses the direction of future research for holistic solutions of using manufacturing knowledge earlier in the product lifecycle.

  11. a Proposal for Generalization of 3d Models

    Science.gov (United States)

    Uyar, A.; Ulugtekin, N. N.

    2017-11-01

    In recent years, 3D models have been created of many cities around the world. Most of the 3D city models have been introduced as completely graphic or geometric models, and the semantic and topographic aspects of the models have been neglected. In order to use 3D city models beyond the task, a generalization is necessary. CityGML is an open data model and XML-based format for the storage and exchange of virtual 3D city models. Level of Details (LoD) which is an important concept for 3D modelling, can be defined as outlined degree or prior representation of real-world objects. The paper aim is first describes some requirements of 3D model generalization, then presents problems and approaches that have been developed in recent years. In conclude the paper will be a summary and outlook on problems and future work.

  12. Bayesian inference of chemical kinetic models from proposed reactions

    KAUST Repository

    Galagali, Nikhil; Marzouk, Youssef M.

    2015-01-01

    © 2014 Elsevier Ltd. Bayesian inference provides a natural framework for combining experimental data with prior knowledge to develop chemical kinetic models and quantify the associated uncertainties, not only in parameter values but also in model

  13. IMPROVING THE INTEROPERABILITY OF DISASTER MODELS: A CASE STUDY OF PROPOSING FIREML FOR FOREST FIRE MODEL

    Directory of Open Access Journals (Sweden)

    W. Jiang

    2018-04-01

    Full Text Available This paper presents a new standardized data format named Fire Markup Language (FireML, extended by the Geography Markup Language (GML of OGC, to elaborate upon the fire hazard model. The proposed FireML is able to standardize the input and output documents of a fire model for effectively communicating with different disaster management systems to ensure a good interoperability. To demonstrate the usage of FireML and testify its feasibility, an adopted forest fire spread model being compatible with FireML is described. And a 3DGIS disaster management system is developed to simulate the dynamic procedure of forest fire spread with the defined FireML documents. The proposed approach will enlighten ones who work on other disaster models' standardization work.

  14. Improving the Interoperability of Disaster Models: a Case Study of Proposing Fireml for Forest Fire Model

    Science.gov (United States)

    Jiang, W.; Wang, F.; Meng, Q.; Li, Z.; Liu, B.; Zheng, X.

    2018-04-01

    This paper presents a new standardized data format named Fire Markup Language (FireML), extended by the Geography Markup Language (GML) of OGC, to elaborate upon the fire hazard model. The proposed FireML is able to standardize the input and output documents of a fire model for effectively communicating with different disaster management systems to ensure a good interoperability. To demonstrate the usage of FireML and testify its feasibility, an adopted forest fire spread model being compatible with FireML is described. And a 3DGIS disaster management system is developed to simulate the dynamic procedure of forest fire spread with the defined FireML documents. The proposed approach will enlighten ones who work on other disaster models' standardization work.

  15. Proposing a Capability Perspective on Digital Business Models

    OpenAIRE

    Bärenfänger, Rieke; Otto, Boris

    2015-01-01

    Business models comprehensively describe the functioning of businesses in contemporary economic, technological, and societal environments. This paper focuses on the characteristics of digital business models from the perspective of capability research and develops a capability model for digital businesses. Following the design science research (DSR) methodology, multiple evaluation and design iterations were performed. Contributions to the design process came from IS/IT practice and the resea...

  16. A proposed model for paradigmatic relations within an emergent discipline

    Directory of Open Access Journals (Sweden)

    Jack D. Glazier

    2002-01-01

    Full Text Available This article is the vehicle for purposing a model for mapping the processual change associated with disciplinary and paradigmatic development. Change of this sort is contingent on the degree of consistency achieved within theory groups. Consistency, in this case, is equated theory and paradigm dominance. The symbolic interactionist tradition supplies the assumptions on which the model is grounded. Examination of the model is accomplished by contrasting it with Thomas Kuhn’s theory. The recent history of library and information science education in the U.S. serves as context and exemplar for application of the model

  17. Proposing an Environmental Excellence Self-Assessment Model

    DEFF Research Database (Denmark)

    Meulengracht Jensen, Peter; Johansen, John; Wæhrens, Brian Vejrum

    2013-01-01

    that the EEA model can be used in global organizations to differentiate environmental efforts depending on the maturity stage of the individual sites. Furthermore, the model can be used to support the decision-making process regarding when organizations should embark on more complex environmental efforts......This paper presents an Environmental Excellence Self-Assessment (EEA) model based on the structure of the European Foundation of Quality Management Business Excellence Framework. Four theoretical scenarios for deploying the model are presented as well as managerial implications, suggesting...

  18. Proposal of a probabilistic dose-response model

    International Nuclear Information System (INIS)

    Barrachina, M.

    1997-01-01

    A biologically updated dose-response model is presented as an alternative to the linear-quadratic model currently in use for cancer risk assessment. The new model is based on the probability functions for misrepair and/or unrepair of DNA lesions, in terms of the radiation damage production rate in the cell (supposedly, a stem cell) and its repair-rate constant. The model makes use, interpreting it on the basis of misrepair probabilities, of the ''dose and dose-rate effectiveness factor'' of ICRP, and provides the way for a continuous extrapolation between the high and low dose-rate regions, ratifying the ''linear non-threshold hypothesis'' as the main option. Anyhow, the model throws some doubts about the additive property of the dose. (author)

  19. A Proposed Conceptual Model to Measure Unwarranted Practice Variation

    National Research Council Canada - National Science Library

    Barr, Andrew M

    2007-01-01

    .... Employing a unit of analysis of the U.S. Army healthcare system and utilizing research by Wennberg and the Institute of Medicine, a model describing healthcare quality in terms of unwarranted practice variation and healthcare outcomes...

  20. comparative analysis of some existing kinetic models with proposed

    African Journals Online (AJOL)

    IGNATIUS NWIDI

    two statistical parameters namely; linear regression coefficient of correlation (R2) and ... Keynotes: Heavy metals, Biosorption, Kinetics Models, Comparative analysis, Average Relative Error. 1. ... If the flow rate is low, a simple manual batch.

  1. Proposal for a new CAPE-OPEN Object Model

    Science.gov (United States)

    Process simulation applications require the exchange of significant amounts of data between the flowsheet environment, unit operation model, and thermodynamic server. Packing and unpacking various data types and exchanging data using structured text-based architectures, including...

  2. 2012 Community Earth System Model (CESM) Tutorial - Proposal to DOE

    Energy Technology Data Exchange (ETDEWEB)

    Holland, Marika [National Center for Atmospheric Research, Boulder, CO (United States); Bailey, David A [National Center for Atmospheric Research, Boulder, CO (United States)

    2013-03-18

    The Community Earth System Model (CESM) is a fully-coupled, global climate model that provides state-of-the-art computer simulations of the Earth's past, present, and future climate states. This document provides the agenda and list of participants for the conference. Web materials for all lectures and practical sessions available from: http://www.cesm.ucar.edu/events/tutorials/073012/ .

  3. a Proposed Benchmark Problem for Scatter Calculations in Radiographic Modelling

    Science.gov (United States)

    Jaenisch, G.-R.; Bellon, C.; Schumm, A.; Tabary, J.; Duvauchelle, Ph.

    2009-03-01

    Code Validation is a permanent concern in computer modelling, and has been addressed repeatedly in eddy current and ultrasonic modeling. A good benchmark problem is sufficiently simple to be taken into account by various codes without strong requirements on geometry representation capabilities, focuses on few or even a single aspect of the problem at hand to facilitate interpretation and to avoid that compound errors compensate themselves, yields a quantitative result and is experimentally accessible. In this paper we attempt to address code validation for one aspect of radiographic modeling, the scattered radiation prediction. Many NDT applications can not neglect scattered radiation, and the scatter calculation thus is important to faithfully simulate the inspection situation. Our benchmark problem covers the wall thickness range of 10 to 50 mm for single wall inspections, with energies ranging from 100 to 500 keV in the first stage, and up to 1 MeV with wall thicknesses up to 70 mm in the extended stage. A simple plate geometry is sufficient for this purpose, and the scatter data is compared on a photon level, without a film model, which allows for comparisons with reference codes like MCNP. We compare results of three Monte Carlo codes (McRay, Sindbad and Moderato) as well as an analytical first order scattering code (VXI), and confront them to results obtained with MCNP. The comparison with an analytical scatter model provides insights into the application domain where this kind of approach can successfully replace Monte-Carlo calculations.

  4. Product/Service-Systems: Proposal for models and terminology

    DEFF Research Database (Denmark)

    Matzen, Detlef; Tan, Adrian; Andreasen, Mogens Myrup

    2005-01-01

    very blurred and ill defined. This paper will try to identify the fundamental characteristics of PSS and propose a system of concepts that can be used to describe and discuss the phenomenon, for the purpose of developing new PSS solutions. Coming from a tradition of product development research......Over recent years a growing number of studies and research programmes have been conducted on the issue of product/service-systems (PSS) [1, 2] and results have been presented at this row of symposia [3, 4]. These studies usually analyse the potential of integrated solutions to reduce...... the environmental impacts of human consumption activity or optimise a company’s ability to cope with the influences arising from the emerging globalisation of economic and business activities. Since there has not been worked on a coherent terminology for the terms and concepts used in PSS research, the area remains...

  5. Psychological debriefing (PD of trauma: a proposed model for Africa

    Directory of Open Access Journals (Sweden)

    E L Van Dyk

    2010-03-01

    Full Text Available Africa is a continent with severe trauma. Traumatic events include experiences of child soldiers, people living in war and conflict zones, and people struggling with the HIV/AIDS pandemic. These events cause high levels of trauma. The trauma causes psychological disorders like post traumatic stress disorder, acute stress disorder and combat stress reaction, specific in the military environment. This article focuses on a better understanding of the implications of trauma for military people and civilians. It discusses the different theories and models of psychological debriefing. Lastly the article discusses psychological debriefing models for military forces and the civil ian population to prevent severe psychopathology after traumatic incidents in Africa.

  6. Queering Constructs: Proposing a Dynamic Gender and Sexuality Model

    Science.gov (United States)

    Jourian, T. J.

    2015-01-01

    Higher education educators commonly understand social identities, including gender, to be fluid and dynamic. Lev's (2004) model of four components of sexual identity is commonly used to demonstrate the fluidity of sex, gender, and sexuality for individuals, but it does little to address the fixedness of those constructs. Through a multipronged…

  7. Proposing a Metaliteracy Model to Redefine Information Literacy

    Science.gov (United States)

    Jacobson, Trudi E.; Mackey, Thomas P.

    2013-01-01

    Metaliteracy is envisioned as a comprehensive model for information literacy to advance critical thinking and reflection in social media, open learning settings, and online communities. At this critical time in higher education, an expansion of the original definition of information literacy is required to include the interactive production and…

  8. Hemodynamic parameters change earlier than tissue oxygen tension in hemorrhage.

    Science.gov (United States)

    Pestel, Gunther J; Fukui, Kimiko; Kimberger, Oliver; Hager, Helmut; Kurz, Andrea; Hiltebrand, Luzius B

    2010-05-15

    Untreated hypovolemia results in impaired outcome. This study tests our hypothesis whether general hemodynamic parameters detect acute blood loss earlier than monitoring parameters of regional tissue beds. Eight pigs (23-25 kg) were anesthetized and mechanically ventilated. A pulmonary artery catheter and an arterial catheter were inserted. Tissue oxygen tension was measured with Clark-type electrodes in the jejunal and colonic wall, in the liver, and subcutaneously. Jejunal microcirculation was assessed by laser Doppler flowmetry (LDF). Intravascular volume was optimized using difference in pulse pressure (dPP) to keep dPP below 13%. Sixty minutes after preparation, baseline measurements were taken. At first, 5% of total blood volume was withdrawn, followed by another 5% increment, and then in 10% increments until death. After withdrawal of 5% of estimated blood volume, dPP increased from 6.1% +/- 3.0% to 20.8% +/- 2.7% (P < 0.01). Mean arterial pressure (MAP), mean pulmonary artery pressure (PAP) and pulmonary artery occlusion pressure (PAOP) decreased with a blood loss of 10% (P < 0.01). Cardiac output (CO) changed after a blood loss of 20% (P < 0.05). Tissue oxygen tension in central organs, and blood flow in the jejunal muscularis decreased (P < 0.05) after a blood loss of 20%. Tissue oxygen tension in the skin, and jejunal mucosa blood flow decreased (P < 0.05) after a blood loss of 40% and 50%, respectively. In this hemorrhagic pig model systemic hemodynamic parameters were more sensitive to detect acute hypovolemia than tissue oxygen tension measurements or jejunal LDF measurements. Acute blood loss was detected first by dPP. Copyright (c) 2010 Elsevier Inc. All rights reserved.

  9. Proposing a Formalised Model for Mindful Information Systems Offshoring

    Science.gov (United States)

    Costello, Gabriel J.; Coughlan, Chris; Donnellan, Brian; Gadatsch, Andreas

    The central thesis of this chapter is that mathematical economics can provide a novel approach to the examination of offshoring business decisions and provide an impetus for future research in the area. A growing body of research indicates that projected cost savings from IT offshoring projects are not being met. Furthermore, evidence suggests that decision-making processes have been more emotional than rational, and that many offshoring arrangements have been rushed into without adequate analysis of the true costs involved. Building on the concept of mindfulness and mindlessness introduced to the IS literature by Swanson and Ramiller, a cost equation is developed using “deductive reasoning rather than inductive study” in the tradition of mathematical economics. The model endeavours to capture a wide range of both the quantitative and qualitative parameters. Although the economic model is illustrated against the background of a European scenario, the theoretical framework is generic and applicable to organisations in any global location.

  10. Proposal for a telehealth concept in the translational research model.

    Science.gov (United States)

    Silva, Angélica Baptista; Morel, Carlos Médicis; Moraes, Ilara Hämmerli Sozzi de

    2014-04-01

    To review the conceptual relationship between telehealth and translational research. Bibliographical search on telehealth was conducted in the Scopus, Cochrane BVS, LILACS and MEDLINE databases to find experiences of telehealth in conjunction with discussion of translational research in health. The search retrieved eight studies based on analysis of models of the five stages of translational research and the multiple strands of public health policy in the context of telehealth in Brazil. The models were applied to telehealth activities concerning the Network of Human Milk Banks, in the Telemedicine University Network. The translational research cycle of human milk collected, stored and distributed presents several integrated telehealth initiatives, such as video conferencing, and software and portals for synthesizing knowledge, composing elements of an information ecosystem, mediated by information and communication technologies in the health system. Telehealth should be composed of a set of activities in a computer mediated network promoting the translation of knowledge between research and health services.

  11. Convective effects in a regulatory and proposed fire model

    International Nuclear Information System (INIS)

    Wix, S.D.; Hohnstreiter, G.F.

    1995-01-01

    Radiation is the dominant mode of heat transfer in large fires. However, convection can be as much as 10 to 20 percent of the total heat transfer to an object in a large fire. The current radioactive material transportation packaging regulations include convection as a mode of heat transfer in the accident condition scenario. The current International Atomic Energy Agency Safety Series 6 packaging regulation states ''the convection coefficient shall be that value which the designer can justify if the package were exposed to the specified fire''. The current Title 10, Code of Federal Regulations, Part 71 (10CFR71) packaging regulation states ''when significant, convection heat input must be included on the basis of still, ambient air at 800 degrees C (1475 degrees F)''. Two questions that can arise in an analysts mind from an examination of the packaging regulations is whether convection is significant and whether convection should be included in the design analysis of a radioactive materials transportation container. The objective of this study is to examine the convective effects on an actual radioactive materials transportation package using a regulatory and a proposed thermal boundary condition

  12. Proposal of a model of mammalian neural induction

    Science.gov (United States)

    Levine, Ariel J.; Brivanlou, Ali H.

    2009-01-01

    How does the vertebrate embryo make a nervous system? This complex question has been at the center of developmental biology for many years. The earliest step in this process – the induction of neural tissue – is intimately linked to patterning of the entire early embryo, and the molecular and embryological basis these processes are beginning to emerge. Here, we analyze classic and cutting-edge findings on neural induction in the mouse. We find that data from genetics, tissue explants, tissue grafting, and molecular marker expression support a coherent framework for mammalian neural induction. In this model, the gastrula organizer of the mouse embryo inhibits BMP signaling to allow neural tissue to form as a default fate – in the absence of instructive signals. The first neural tissue induced is anterior and subsequent neural tissue is posteriorized to form the midbrain, hindbrain, and spinal cord. The anterior visceral endoderm protects the pre-specified anterior neural fate from similar posteriorization, allowing formation of forebrain. This model is very similar to the default model of neural induction in the frog, thus bridging the evolutionary gap between amphibians and mammals. PMID:17585896

  13. A proposal of a renormalizable Nambu-Jona-Lasinio model

    Science.gov (United States)

    Cabo Montes de Oca, Alejandro

    2018-03-01

    A local and gauge invariant gauge field model including Nambu-Jona-Lasinio (NJL) and QCD Lagrangian terms in its action is introduced. Surprisingly, it becomes power counting renormalizable. This occurs thanks to the presence of action terms which modify the quark propagators, to become more decreasing that the Dirac one at large momenta in a Lee-Wick form, implying power counting renormalizability. The appearance of finite quark masses already in the tree approximation in the scheme is determined by the fact that the new action terms explicitly break chiral invariance. In this starting work we present the renormalized Feynman diagram expansion of the model and derive the formula for the degree of divergence of the diagrams. An explanation for the usual exclusion of the added Lagrangian terms is presented. In addition, the primitíve divergent graphs are identified. We start their evaluation by calculating the simpler contribution to the gluon polarization operator. The divergent and finite parts both result transverse as required by gauge invariance. The full evaluation of the various primitive divergences, which are required for completely defining the counterterm Feynman expansion will be considered in coming works, for further allowing to discuss the flavour symmetry breaking and unitarity.

  14. The earlier identification of the seedless characteristic of the wampee

    African Journals Online (AJOL)

    Jane

    2010-12-13

    Dec 13, 2010 ... the production of new seedless wampee cultivars in recent years were operated. ... increase burliness rate in hybridization. In order to earlier ... methods is greatly limited due to a long juvenile phase of ... Plant materials .... This fragment may be linked ... reduce high temperature which affected pollen germi-.

  15. Prescription stimulant use is associated with earlier onset of psychosis.

    Science.gov (United States)

    Moran, Lauren V; Masters, Grace A; Pingali, Samira; Cohen, Bruce M; Liebson, Elizabeth; Rajarethinam, R P; Ongur, Dost

    2015-12-01

    A childhood history of attention deficit hyperactivity disorder (ADHD) is common in psychotic disorders, yet prescription stimulants may interact adversely with the physiology of these disorders. Specifically, exposure to stimulants leads to long-term increases in dopamine release. We therefore hypothesized that individuals with psychotic disorders previously exposed to prescription stimulants will have an earlier onset of psychosis. Age of onset of psychosis (AOP) was compared in individuals with and without prior exposure to prescription stimulants while controlling for potential confounding factors. In a sample of 205 patients recruited from an inpatient psychiatric unit, 40% (n = 82) reported use of stimulants prior to the onset of psychosis. Most participants were prescribed stimulants during childhood or adolescence for a diagnosis of ADHD. AOP was significantly earlier in those exposed to stimulants (20.5 vs. 24.6 years stimulants vs. no stimulants, p drugs of abuse, and family history of a first-degree relative with psychosis, the association between stimulant exposure and earlier AOP remained significant. There was a significant gender × stimulant interaction with a greater reduction in AOP for females, whereas the smaller effect of stimulant use on AOP in males did not reach statistical significance. In conclusion, individuals with psychotic disorders exposed to prescription stimulants had an earlier onset of psychosis, and this relationship did not appear to be mediated by IQ or cannabis. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Comprehensive methods for earlier detection and monitoring of forest decline

    Science.gov (United States)

    Jennifer Pontius; Richard Hallett

    2014-01-01

    Forested ecosystems are threatened by invasive pests, pathogens, and unusual climatic events brought about by climate change. Earlier detection of incipient forest health problems and a quantitatively rigorous assessment method is increasingly important. Here, we describe a method that is adaptable across tree species and stress agents and practical for use in the...

  17. A proposed model of e-trust for electronic banking

    Directory of Open Access Journals (Sweden)

    Neda Yousefi

    2015-11-01

    Full Text Available Customer’s trust is the most important and one of the key factors of success in e-commerce. However, trust is the essential aspects of e-banking adoption and the main element for building long-term relationships with the bank's customers. So the purpose of this research is to investigate the factors influencing on customer′s trust in e-banking services and prioritize them. Therefore, designed questionnaire was distributed among 177 electronic service customers in number of banks in the city of Karaj, Iran. Likert quintuplet scales were used to measure the variables. After collecting the questionnaires, the data were analyzed by structural equation modeling (by using LISREL 8.5. The results revealed that quality of electronic services such as ease of use, privacy and security, individual characteristics of customers such as disposition to trust and features of bank such as reputation, size and dependence on government, have had the greatest effect on customer′s trust in e-banking services.

  18. Proposed changes to the NDS introductory material. Revisions to the earlier version of this document

    International Nuclear Information System (INIS)

    Reich, C.W.

    2001-01-01

    This paper includes some comments of the previously submitted paper under the same title referring especially to the following: general policies in treatment of α decay hindrance factors, ground states, γ and β transitions, magnetic moments, regions of strong nuclear deformation, α decay

  19. Social Security reform: evaluating current proposals. Latest results of the EBRI-SSASIM2 policy simulation model.

    Science.gov (United States)

    Copeland, C; VanDerhei, J; Salisbury, D L

    1999-06-01

    The present Social Security program has been shown to be financially unsustainable in the future without modification to the current program. The purpose of this Issue Brief, EBRI's fourth in a series on Social Security reform, is threefold: to illustrate new features of the EBRI-SSASIM2 policy simulation model not available in earlier EBRI publications, to expand quantitative analysis to specific proposals, and to evaluate the uncertainty involved in proposals that rely on equity investment. This analysis compares the Gregg/Breaux-Kolbe/Stenholm (GB-KS) and Moynihan/Kerrey proposals with three generic or "traditional" reforms: increasing taxes, reducing benefits, and/or increasing the retirement age. Both proposals would create individual accounts by "carving out" funds from current Social Security payroll taxes. This analysis also examines other proposed changes that would "add on" to existing Social Security funds through the use of general revenue transfers and/or investment in the equities market. President Clinton has proposed a general revenue transfer and the collective investment of some of the OASDI trust fund assets in equities. Reps. Archer and Shaw have proposed a general revenue tax credit to establish individual accounts that would be invested partially in the equities markets. When comparing Social Security reform proposals that would specifically alter benefit levels, the Moynihan/Kerrey bill compares quite favorably with the other proposals in both benefit levels and payback ratios, when individuals elect to use the individual account option. In contrast, the GB-KS bills do not compare quite as favorably for their benefit levels, but do compare favorably in terms of payback ratios. An important comparison in these bills is the administrative costs of managing the individual accounts, since benefits can be lowered by up to 23 percent when going from the assumed low to high administrative costs. Moreover, allowing individuals to decide whether to

  20. A proposed wind shift model for the German reactor safety study

    International Nuclear Information System (INIS)

    Aldrich, D.C.; Bayer, A.; Schueckler, M.

    1979-04-01

    To account for hourly wind direction changes, a wind shift model has been proposed. Using hourly recorded wind speed and direction data, the model modifies the angular distribution of radionuclide concentrations calculated by a straightline model, and is intended to better represent the concentrations in areas close to the reactor where potential doses might exceed the threshold level for early fatalities. 115 weather sequences were used, both with and without the proposed wind shift model, to calculate probability distributions for early fatalities. The use of the proposed model results in a reduction of the mean and peak values of that distribution by 36% and 29%, respectively. (orig./HP) [de

  1. Proposal for operator's mental model using the concept of multilevel flow modeling

    International Nuclear Information System (INIS)

    Yoshimura, Seiichi; Takano, Kenichi; Sasou, Kunihide

    1995-01-01

    It is necessary to analyze an operator's thinking process and a operator team's intension forming process for preventing human errors in a highly advanced huge system like a nuclear power plant. Central Research Institute of Electric Power Industry is promoting a research project to establish human error prevention countermeasures by modeling the thinking and intension forming process. The important is the future prediction and the cause identification when abnormal situations occur in a nuclear power plant. The concept of Multilevel Flow Modeling (MFM) seems to be effective as an operator's mental model which performs the future prediction and the cause identification. MFM is a concept which qualitatively describes the plant functions by energy and mass flows and also describes the plant status by breaking down the targets in a hierarchical manner which a plant should achieve. In this paper, an operator's mental model using the concept of MFM was proposed and a nuclear power plant diagnosis support system using MFM was developed. The system evaluation test by personnel who have operational experience in nuclear power plants revealed that MFM was superior in the future prediction and the cause identification to a traditional nuclear power plant status display system which used mimics and trends. MFM proved to be useful as an operator's mental model by the test. (author)

  2. Prescription Stimulant Use is Associated with Earlier Onset of Psychosis

    OpenAIRE

    Moran, Lauren V.; Masters, Grace A.; Pingali, Samira; Cohen, Bruce M.; Liebson, Elizabeth; Rajarethinam, R.P.; Ongur, Dost

    2015-01-01

    A childhood history of attention deficit hyperactivity disorder (ADHD) is common in psychotic disorders, yet prescription stimulants may interact adversely with the physiology of these disorders. Specifically, exposure to stimulants leads to long-term increases in dopamine release. We therefore hypothesized that individuals with psychotic disorders previously exposed to prescription stimulants will have an earlier onset of psychosis. Age of onset of psychosis (AOP) was compared in individuals...

  3. A New Proposed Cost Model for List Accessing Problem using Buffering

    OpenAIRE

    Mohanty, Rakesh; Bhoi, Seetaya; Tripathy, Sasmita

    2011-01-01

    There are many existing well known cost models for the list accessing problem. The standard cost model developed by Sleator and Tarjan is most widely used. In this paper, we have made a comprehensive study of the existing cost models and proposed a new cost model for the list accessing problem. In our proposed cost model, for calculating the processing cost of request sequence using a singly linked list, we consider the access cost, matching cost and replacement cost. The cost of processing a...

  4. Earlier vegetation green-up has reduced spring dust storms.

    Science.gov (United States)

    Fan, Bihang; Guo, Li; Li, Ning; Chen, Jin; Lin, Henry; Zhang, Xiaoyang; Shen, Miaogen; Rao, Yuhan; Wang, Cong; Ma, Lei

    2014-10-24

    The observed decline of spring dust storms in Northeast Asia since the 1950s has been attributed to surface wind stilling. However, spring vegetation growth could also restrain dust storms through accumulating aboveground biomass and increasing surface roughness. To investigate the impacts of vegetation spring growth on dust storms, we examine the relationships between recorded spring dust storm outbreaks and satellite-derived vegetation green-up date in Inner Mongolia, Northern China from 1982 to 2008. We find a significant dampening effect of advanced vegetation growth on spring dust storms (r = 0.49, p = 0.01), with a one-day earlier green-up date corresponding to a decrease in annual spring dust storm outbreaks by 3%. Moreover, the higher correlation (r = 0.55, p storm outbreak ratio (the ratio of dust storm outbreaks to times of strong wind events) indicates that such effect is independent of changes in surface wind. Spatially, a negative correlation is detected between areas with advanced green-up dates and regional annual spring dust storms (r = -0.49, p = 0.01). This new insight is valuable for understanding dust storms dynamics under the changing climate. Our findings suggest that dust storms in Inner Mongolia will be further mitigated by the projected earlier vegetation green-up in the warming world.

  5. PROPOSED SUITE OF MODELS FOR ESTIMATING DOSE RESULTING FROM EXPOSURES BY THE DERMAL ROUTE

    Science.gov (United States)

    Recent risk assessment guidance emphasizes consideration of mechanistic factors for influencing disposition of a toxicant. To incorporate mechanistic information into risk assessment, a suite of models is proposed for use in characterizing and quantifying dosimetry of toxic age...

  6. An Analytical Analysis of Hydraulic Jump in Triangular Channel: A Proposed Model

    Science.gov (United States)

    Khan, S. A.

    2013-05-01

    The paper presents the theoretical study of hydraulic jump in triangular channel section. Presuming the jump as one dimensional free shear layer with hydrostatic pressure distribution across it and using momentum equation, specific force equation is obtained. Using the specific force equation and eddy viscosity equation, analytical models for sequent depth, dimensionless profile, turbulent shear stress distribution and energy loss for various initial Froude numbers have been obtained. The proposed models for sequent depth and energy loss are also compared with the other developed models. The proposed energy loss model also provides the energy loss at any point along the jump, while this provision is not available in the models of other investigators. Newton-Raphson and Runge-Kutta methods are used for the solution of the proposed model. The outcome of this study can be used in the design of stilling basin floor and side walls on permeable foundations.

  7. Alcoholism. Earlier diagnosis and definition of the problem.

    Science.gov (United States)

    Girard, D E; Carlton, B E

    1978-07-01

    There are important measurements of alcoholism that are poorly understood by physicians. Professional attitudes toward alcoholic patients are often counterproductive. Americans spend about $30 billion on alcohol a year and most adults drink alcohol. Even though traditional criteria allow for recognition of the disease, diagnosis is often made late in the natural course, when intervention fails. Alcoholism is a major health problem and accounts for 10 percent of total health care costs. Still, this country's 10 million adult alcoholics come from a pool of heavy drinkers with well defined demographic characteristics. These social, cultural and familial traits, along with subtle signs of addiction, allow for earlier diagnosis. Although these factors alone do not establish a diagnosis of alcoholism, they should alert a physician that significant disease may be imminent. Focus must be directed to these aspects of alcoholism if containment of the problem is expected.

  8. 78 FR 38091 - Airworthiness Criteria: Proposed Airship Design Criteria for Lockheed Martin Aeronautics Model...

    Science.gov (United States)

    2013-06-25

    ..., 2012 Lockheed Martin Aeronautics submitted an application for type certification for the model LMZ1M..., views, or arguments as they may desire. Commenters should identify the proposed design criteria on the... Lockheed Martin Aeronautics submitted an application for type certification for the model LMZ1M airship...

  9. Proposed Model of Information Behaviour in Crisis: The Case of Hurricane Sandy

    Science.gov (United States)

    Lopatovska, Irene; Smiley, Bobby

    2013-01-01

    Introduction: The paper proposes a model of information behaviour in crisis. No previous model has attempted to integrate information resources, information behaviour and needs of the storm-affected communities within the temporal stages of a natural disaster. Method: The study was designed as autoethnography. The data were collected through a…

  10. Non-monotonic reasoning in conceptual modeling and ontology design: A proposal

    CSIR Research Space (South Africa)

    Casini, G

    2013-06-01

    Full Text Available -1 2nd International Workshop on Ontologies and Conceptual Modeling (Onto.Com 2013), Valencia, Spain, 17-21 June 2013 Non-monotonic reasoning in conceptual modeling and ontology design: A proposal Giovanni Casini1 and Alessandro Mosca2 1...

  11. The Proposed Model of Collaborative Virtual Learning Environment for Introductory Programming Course

    Science.gov (United States)

    Othman, Mahfudzah; Othman, Muhaini

    2012-01-01

    This paper discusses the proposed model of the collaborative virtual learning system for the introductory computer programming course which uses one of the collaborative learning techniques known as the "Think-Pair-Share". The main objective of this study is to design a model for an online learning system that facilitates the…

  12. BLAM (Benthic Light Availability Model): A Proposed Model of Hydrogeomorphic Controls on Light in Rivers

    Science.gov (United States)

    Julian, J. P.; Doyle, M. W.; Stanley, E. H.

    2006-12-01

    Light is vital to the dynamics of aquatic ecosystems. It drives photosynthesis and photochemical reactions, affects thermal structure, and influences behavior of aquatic biota. Despite the fundamental role of light to riverine ecosystems, light studies in rivers have been mostly neglected because i) boundary conditions (e.g., banks, riparian vegetation) make ambient light measurements difficult, and ii) the optical water quality of rivers is highly variable and difficult to characterize. We propose a benthic light availability model (BLAM) that predicts the percent of incoming photosynthetically active radiation (PAR) available at the river bed. BLAM was developed by quantifying light attenuation of the five hydrogeomorphic controls that dictate riverine light availability: topography, riparian vegetation, channel geometry, optical water quality, and water depth. BLAM was calibrated using hydrogeomorphic data and light measurements from two rivers: Deep River - a 5th-order, turbid river in central North Carolina, and Big Spring Creek - a 2nd-order, optically clear stream in central Wisconsin. We used a series of four PAR sensors to measure i) above-canopy PAR, ii) PAR above water surface, iii) PAR below water surface, and iv) PAR on stream bed. These measurements were used to develop empirical light attenuation coefficients, which were then used in combination with optical water quality measurements, shading analyses, channel surveys, and flow records to quantify the spatial and temporal variability in riverine light availability. Finally, we apply BLAM to the Baraboo River - a 6th-order, 120-mile, unimpounded river in central Wisconsin - in order to characterize light availability along the river continuum (from headwaters to mouth).

  13. A Framework Proposal For Choosing A New Business Implementation Model In Henkel

    OpenAIRE

    Li, Tsz Wan

    2015-01-01

    Henkel's New Business team is a corporate venturing unit that explores corporate entrepreneurial activities on behalf of Henkel Adhesives Technologies. The new business ideas are implemented through one of these models: incubator, venturing or innovation ecosystem. In current practice, there is no systematic framework in place to choose the implementation model. The goal of the thesis is to propose a framework for choosing the most appropriate model for implementation of a new business idea i...

  14. Two-Dimensional Model Test Study of New Western Breakwater Proposal for Port of Hanstholm

    DEFF Research Database (Denmark)

    Eldrup, Mads Røge; Andersen, Thomas Lykke

    The present report presents results from a two-dimensional model test study carried out at Aalborg University in December 2016 with the proposed trunk section for the new western breakwater in Port of Hanstholm. The objectives of the model tests were to study the stability of the armour layer, toe...... erosion, overtopping and transmission. The scale used for the model tests was 1:61.5. Unless otherwise specified all values given in this report are prototype values converted from the model to prototype according to the Froude model law....

  15. Outcomes of arthroscopic lateral epicondylitis release: Should we treat earlier?

    Science.gov (United States)

    Soeur, L; Desmoineaux, P; Devillier, A; Pujol, N; Beaufils, P

    2016-10-01

    When managed conservatively, lateral epicondylitis often subsides only after considerable time, during which social and occupational activities are severely disrupted. If conservative management fails, a recently introduced option is arthroscopic release of the extensor carpi radialis brevis (ECRB). The primary objective of this study was to compare clinical outcomes of this procedure according to preoperative symptom duration. Earlier arthroscopic release is associated with better functional outcomes. Consecutive patients with arthroscopically managed lateral epicondylitis were included in a retrospective study. Arthroscopy was performed only after at least 6 months of conservative treatment. The criteria to evaluate the clinical outcomes were the Nirschl and Quick-DASH scores, muscle strength, time to pain relief, and percentage of functional recovery. Thirty-five patients were evaluated at a median of 4 years (range: 1-12 years) after surgery. Mean preoperative symptom duration was 18 months (range: 6-106 months) with a mean sick leave duration of 2.3±4.9 months. Postoperatively, mean time to recovery was 37.5 days (range: 7 days to 5 years) and mean sick leave duration was 2.4±2.4 months. The mean Quick-DASH score was 15.9±19.1. The Nirschl score improved significantly, from 26.4±7.9 to 66.3±16.3. The initial muscle strength deficit was 10.1±33.2% and muscle strength at last follow-up was increased by 4.3±30.3%. Symptom duration showed no correlations with any of the clinical outcome measures. Outcomes after arthroscopic release were not associated with symptom duration in this study. Nevertheless, the good clinical outcomes support treatment with arthroscopic release after only 6 months of conservative management. IV, retrospective study. Copyright © 2016. Published by Elsevier Masson SAS.

  16. Cardiac Complications, Earlier Treatment, and Initial Disease Severity in Kawasaki Disease.

    Science.gov (United States)

    Abrams, Joseph Y; Belay, Ermias D; Uehara, Ritei; Maddox, Ryan A; Schonberger, Lawrence B; Nakamura, Yosikazu

    2017-09-01

    To assess if observed higher observed risks of cardiac complications for patients with Kawasaki disease (KD) treated earlier may reflect bias due to confounding from initial disease severity, as opposed to any negative effect of earlier treatment. We used data from Japanese nationwide KD surveys from 1997 to 2004. Receipt of additional intravenous immunoglobulin (IVIG) (data available all years) or any additional treatment (available for 2003-2004) were assessed as proxies for initial disease severity. We determined associations between earlier or later IVIG treatment (defined as receipt of IVIG on days 1-4 vs days 5-10 of illness) and cardiac complications by stratifying by receipt of additional treatment or by using logistic modeling to control for the effect of receiving additional treatment. A total of 48 310 patients with KD were included in the analysis. In unadjusted analysis, earlier IVIG treatment was associated with a higher risk for 4 categories of cardiac complications, including all major cardiac complications (risk ratio, 1.10; 95% CI, 1.06-1.15). Stratifying by receipt of additional treatment removed this association, and earlier IVIG treatment became protective against all major cardiac complications when controlling for any additional treatment in logistic regressions (OR, 0.90; 95% CI, 0.80-1.00). Observed higher risks of cardiac complications among patients with KD receiving IVIG treatment on days 1-4 of the illness are most likely due to underlying higher initial disease severity, and patients with KD should continue to be treated with IVIG as early as possible. Published by Elsevier Inc.

  17. The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas.

    Science.gov (United States)

    Kessler, R C; Aguilar-Gaxiola, S; Alonso, J; Bromet, E J; Gureje, O; Karam, E G; Koenen, K C; Lee, S; Liu, H; Pennell, B-E; Petukhova, M V; Sampson, N A; Shahly, V; Stein, D J; Atwoli, L; Borges, G; Bunting, B; de Girolamo, G; Gluzman, S F; Haro, J M; Hinkov, H; Kawakami, N; Kovess-Masfety, V; Navarro-Mateu, F; Posada-Villa, J; Scott, K M; Shalev, A Y; Ten Have, M; Torres, Y; Viana, M C; Zaslavsky, A M

    2017-09-19

    Although earlier trauma exposure is known to predict posttraumatic stress disorder (PTSD) after subsequent traumas, it is unclear whether this association is limited to cases where the earlier trauma led to PTSD. Resolution of this uncertainty has important implications for research on pretrauma vulnerability to PTSD. We examined this issue in the World Health Organization (WHO) World Mental Health (WMH) Surveys with 34 676 respondents who reported lifetime trauma exposure. One lifetime trauma was selected randomly for each respondent. DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) PTSD due to that trauma was assessed. We reported in a previous paper that four earlier traumas involving interpersonal violence significantly predicted PTSD after subsequent random traumas (odds ratio (OR)=1.3-2.5). We also assessed 14 lifetime DSM-IV mood, anxiety, disruptive behavior and substance disorders before random traumas. We show in the current report that only prior anxiety disorders significantly predicted PTSD in a multivariate model (OR=1.5-4.3) and that these disorders interacted significantly with three of the earlier traumas (witnessing atrocities, physical violence victimization and rape). History of witnessing atrocities significantly predicted PTSD after subsequent random traumas only among respondents with prior PTSD (OR=5.6). Histories of physical violence victimization (OR=1.5) and rape after age 17 years (OR=17.6) significantly predicted only among respondents with no history of prior anxiety disorders. Although only preliminary due to reliance on retrospective reports, these results suggest that history of anxiety disorders and history of a limited number of earlier traumas might usefully be targeted in future prospective studies as distinct foci of research on individual differences in vulnerability to PTSD after subsequent traumas.Molecular Psychiatry advance online publication, 19 September 2017; doi:10.1038/mp.2017.194.

  18. The Motivational Knowledge Management Model: proposal to apply it in the library sector

    Directory of Open Access Journals (Sweden)

    Daniel López-Fernández

    2016-12-01

    Full Text Available In professional environments, attention paid to aspects such as supervisory styles, interpersonal relationships and workers eagerness can have a positive impact on employee motivation and, consequently, on their performance and well-being. To achieve this, knowledge management models such as those presented here can be applied. This model generates diagnoses of motivation and recommendations for improvement, both systematically and scientifically. Consequently, it is especially useful for managers and human resource departments. The proposed model can be adapted to different kinds of professional groups, including those in library and documentation services. The suitability, reliability and usefulness of the proposed model have been empirically checked through case studies with 92 students and 166 professionals. The positive results allow us to conclude that the model is effective and useful for assessing and improving motivation.

  19. The ERICAM model: a proposal for amelioration of nuclear liability by funding on the capital markets

    International Nuclear Information System (INIS)

    Tyran, J.R.

    1995-01-01

    The ERICAM model (Environmental Risk Internalization through Capital Markets) includes the capital markets as a source contributing to the coverage of risks due to nuclear activites, thus enhancing the effectiveness and functions of the nuclear liability law. The model proposed will allow higher amounts for compensation and will increase financial security, flow of information, and efficient use of resources. The implementation of the model can be achieved on the financing side by issuing Nuke bonds, linking accident-specific options to government bonds. This will essentially increase the risk coverage compared to present means, and will be a pin-pointed addition to the existing layer system. There are three institutions proposed to act as mediators in the implementation of the model: A government authority to supervise the trade in Nuke bonds. Risk-bearing associations in oder to enhance the model's efficiency, and to reduce transaction costs. Rating agencies that will reduce the expenditure for information. (orig./HP) [de

  20. Proposal for a Method for Business Model Performance Assessment: Toward an Experimentation Tool for Business Model Innovation

    Directory of Open Access Journals (Sweden)

    Antonio Batocchio

    2017-04-01

    Full Text Available The representation of business models has been recently widespread, especially in the pursuit of innovation. However, defining a company’s business model is sometimes limited to discussion and debates. This study observes the need for performance measurement so that business models can be data-driven. To meet this goal, the work proposed as a hypothesis the creation of a method that combines the practices of the Balanced Scorecard with a method of business models representation – the Business Model Canvas. Such a combination was based on study of conceptual adaptation, resulting in an application roadmap. A case study application was performed to check the functionality of the proposition, focusing on startup organizations. It was concluded that based on the performance assessment of the business model it is possible to propose the search for change through experimentation, a path that can lead to business model innovation.

  1. A proposed strategy for the validation of ground-water flow and solute transport models

    International Nuclear Information System (INIS)

    Davis, P.A.; Goodrich, M.T.

    1991-01-01

    Ground-water flow and transport models can be thought of as a combination of conceptual and mathematical models and the data that characterize a given system. The judgment of the validity or invalidity of a model depends both on the adequacy of the data and the model structure (i.e., the conceptual and mathematical model). This report proposes a validation strategy for testing both components independently. The strategy is based on the philosophy that a model cannot be proven valid, only invalid or not invalid. In addition, the authors believe that a model should not be judged in absence of its intended purpose. Hence, a flow and transport model may be invalid for one purpose but not invalid for another. 9 refs

  2. Perceptual sensitivity to spectral properties of earlier sounds during speech categorization.

    Science.gov (United States)

    Stilp, Christian E; Assgari, Ashley A

    2018-02-28

    Speech perception is heavily influenced by surrounding sounds. When spectral properties differ between earlier (context) and later (target) sounds, this can produce spectral contrast effects (SCEs) that bias perception of later sounds. For example, when context sounds have more energy in low-F 1 frequency regions, listeners report more high-F 1 responses to a target vowel, and vice versa. SCEs have been reported using various approaches for a wide range of stimuli, but most often, large spectral peaks were added to the context to bias speech categorization. This obscures the lower limit of perceptual sensitivity to spectral properties of earlier sounds, i.e., when SCEs begin to bias speech categorization. Listeners categorized vowels (/ɪ/-/ɛ/, Experiment 1) or consonants (/d/-/g/, Experiment 2) following a context sentence with little spectral amplification (+1 to +4 dB) in frequency regions known to produce SCEs. In both experiments, +3 and +4 dB amplification in key frequency regions of the context produced SCEs, but lesser amplification was insufficient to bias performance. This establishes a lower limit of perceptual sensitivity where spectral differences across sounds can bias subsequent speech categorization. These results are consistent with proposed adaptation-based mechanisms that potentially underlie SCEs in auditory perception. Recent sounds can change what speech sounds we hear later. This can occur when the average frequency composition of earlier sounds differs from that of later sounds, biasing how they are perceived. These "spectral contrast effects" are widely observed when sounds' frequency compositions differ substantially. We reveal the lower limit of these effects, as +3 dB amplification of key frequency regions in earlier sounds was enough to bias categorization of the following vowel or consonant sound. Speech categorization being biased by very small spectral differences across sounds suggests that spectral contrast effects occur

  3. Two-Dimensional Model Test Study of New Western Breakwater Proposal for Port of Hanstholm

    OpenAIRE

    Eldrup, Mads Røge; Andersen, Thomas Lykke

    2016-01-01

    The present report presents results from a two-dimensional model test study carried out at Aalborg University in December 2016 with the proposed trunk section for the new western breakwater in Port of Hanstholm. The objectives of the model tests were to study the stability of the armour layer, toe erosion, overtopping and transmission. The scale used for the model tests was 1:61.5. Unless otherwise specified all values given in this report are prototype values converted from the model to prot...

  4. Evaluation of a proposed optimization method for discrete-event simulation models

    Directory of Open Access Journals (Sweden)

    Alexandre Ferreira de Pinho

    2012-12-01

    Full Text Available Optimization methods combined with computer-based simulation have been utilized in a wide range of manufacturing applications. However, in terms of current technology, these methods exhibit low performance levels which are only able to manipulate a single decision variable at a time. Thus, the objective of this article is to evaluate a proposed optimization method for discrete-event simulation models based on genetic algorithms which exhibits more efficiency in relation to computational time when compared to software packages on the market. It should be emphasized that the variable's response quality will not be altered; that is, the proposed method will maintain the solutions' effectiveness. Thus, the study draws a comparison between the proposed method and that of a simulation instrument already available on the market and has been examined in academic literature. Conclusions are presented, confirming the proposed optimization method's efficiency.

  5. Proposal of a Model for effective Management and Development of virtual Teams

    Directory of Open Access Journals (Sweden)

    Petr Skyrik

    2010-10-01

    Full Text Available The main aim of this paper is to present a pilot proposal of a model of “Virtual Development Management System” (ViDeMaS which will facilitate more effective management and development of virtual teams. Management and development of virtual teams is not a simple concept. It comprises a body of knowledge from a number of fields and scientific disciplines. The complexity of the concept may not be simplified as it is absolutely essential for full understanding of its nature. In order to gain better orientation in the concept, different perspectives will be used in the description of the model, which will enable us to achieve the goal of the work and to present the main results of the work (creation of a model for Virtual Development Management System. The present paper thus describes from different perspectives the proposal of a sufficiently detailed and complex model that may be utilized both on theoretical and application level.

  6. DEVELOPING AND PROPOSING A CONCEPTUAL MODEL OF THE FLOW EXPERIENCE DURING ONLINE INFORMATION SEARCH

    Directory of Open Access Journals (Sweden)

    Lazoc Alina

    2012-07-01

    Full Text Available Information search is an essential part of the consumer`s decision making process. The online medium offers new opportunities and challenges for information search activities (in and outside the marketing context. We are interested in the way human information experiences and behaviors are affected by this. Very often online games and social web activities are perceived as challenging, engaging and enjoyable, while online information search is far below this evaluation. Our research proposal implies that using the online medium for information search may provoke enjoyable experiences through the flow state, which may in turn positively influence an individual`s exploratory information behavior and encourage his/her pro-active market behavior. The present study sets out to improve the understanding of the online medium`s impact on human`s exploratory behavior. We hypothesize that the inclusion of the online flow experience in our research model will better explain exploratory information search behaviors. A 11-component conceptual framework is proposed to explain the manifestations of flow, its personal and technological determinants and its behavioral consequence in the context of online information search. Our research has the primary purpose to present an integrated online flow model. Its secondary objective is to stimulate extended research in the area of informational behaviors in the digital age. The paper is organized in three sections. In the first section we briefly report the analysis results of the most relevant online flow theory literature and, drawing on it, we are trying to identify variables and relationships among these. In the second part we propose a research model and use prior flow models to specify a range of testable hypothesis. Drawing on the conceptual model developed, the last section of our study presents the final conclusions and proposes further steps in evaluating the model`s validity. Future research directions

  7. The New Digital Media Value Network: Proposing an Interactive Model of Digital Media Value Activities

    Directory of Open Access Journals (Sweden)

    Sylvia Chan-Olmsted

    2016-07-01

    Full Text Available This study models the dynamic nature of today’s media markets using the framework of value-adding activities in the provision and consumption of media products. The proposed user-centric approach introduces the notion that the actions of external users, social media, and interfaces affect the internal value activities of media firms via a feedback loop, and therefore should themselves be considered value activities. The model also suggests a more comprehensive list of indicators for value assessment.

  8. Space-Time Uncertainty and Cosmology: a Proposed Quantum Model of the Universe [ 245Kb

    Directory of Open Access Journals (Sweden)

    Tosto S.

    2013-10-01

    Full Text Available The paper introduces a cosmological model of the quantum universe. The aim of the model is (i to identify the possible mechanism that governs the matter/antimatter ratio existing in the universe and concurrently to propose (ii a reasonable growth mechanism of the universe and (iii a possible explanation of the dark energy. The concept of timespace uncertainty, on which is based the present quantum approach, has been proven able to bridge quantum mechanics and relativity.

  9. Comparison of two analytical models of blanking and proposal of a new model

    NARCIS (Netherlands)

    Klingenberg, W; Singh, UP

    With the development of accurate Finite Element models of the punching/blanking process by the present authors and other researchers, important possibilities emerged to model and analyse the process in a research environment. However, Finite Element models are less well suited for use in a

  10. Proposal for intake model for workers at IPEN-CNEN/SP who handle 131 I

    International Nuclear Information System (INIS)

    Todo, A.S.; Potiens Junior, A.J.; Gaburo, J.C.; Sanches, M.P.; Oliveira, E.M.

    1997-01-01

    The intake model for the two groups of workers at IPEN-CNEN/SP is presented. They handle iodine compounds during the processing of irradiated targets and at labeling of radiopharmaceutical compounds. The intake model for the workers are proposed from the knowledge of the activities carried out in the plant and the internal monitoring program of the workers. In this study, the intake is considered to be taken uniformly during the days of major activities carried out by the workers. In practice, the application of this model has be shown suitable, for the studied groups

  11. PTSD's latent structure in Malaysian tsunami victims: assessing the newly proposed Dysphoric Arousal model.

    Science.gov (United States)

    Armour, Cherie; Raudzah Ghazali, Siti; Elklit, Ask

    2013-03-30

    The underlying latent structure of Posttraumatic Stress Disorder (PTSD) is widely researched. However, despite a plethora of factor analytic studies, no single model has consistently been shown as superior to alternative models. The two most often supported models are the Emotional Numbing and the Dysphoria models. However, a recently proposed five-factor Dysphoric Arousal model has been gathering support over and above existing models. Data for the current study were gathered from Malaysian Tsunami survivors (N=250). Three competing models (Emotional Numbing/Dysphoria/Dysphoric Arousal) were specified and estimated using Confirmatory Factor Analysis (CFA). The Dysphoria model provided superior fit to the data compared to the Emotional Numbing model. However, using chi-square difference tests, the Dysphoric Arousal model showed a superior fit compared to both the Emotional Numbing and Dysphoria models. In conclusion, the current results suggest that the Dysphoric Arousal model better represents PTSD's latent structure and that items measuring sleeping difficulties, irritability/anger and concentration difficulties form a separate, unique PTSD factor. These results are discussed in relation to the role of Hyperarousal in PTSD's on-going symptom maintenance and in relation to the DSM-5. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  12. A proposed model for the transfer of environmental tritium to man and tritium metabolism in model animals

    International Nuclear Information System (INIS)

    Saito, Masahiro; Ishida, M.R.

    1987-01-01

    To evaluate the accumulated dose in human bodies due to the environmental tritium, it is of required to establish an adequate model for the tritium transfer from the environment to man and to obtain enough information on the metabolic behaviour of tritium in animal bodies using model animal system. In this report, first we describe about a proposed model for the transfer of environmental tritium to man and secondly mention briefly about the recent works on the tritium metabolism in newborn animals which have been treated as a model system of tritium intake through food chain. (author)

  13. A proposal for operator team behavior model and operator's thinking mechanism

    International Nuclear Information System (INIS)

    Yoshimura, Seiichi; Takano, Kenichi; Sasou, Kunihide

    1995-01-01

    Operating environment in huge systems like nuclear power plants or airplanes is changing rapidly with the advance of computer technology. It is necessary to elucidate thinking process of operators and decision-making process of an operator team in abnormal situations, in order to prevent human errors under such environment. The Central Research Institute of Electric Power Industry is promoting a research project to establish human error prevention countermeasures by modeling and simulating the thinking process of operators and decision-making process of an operator team. In the previous paper, application of multilevel flow modeling was proposed to a mental model which conducts future prediction and cause identification, and the characteristics were verified by experienced plant operators. In this paper, an operator team behavior model and a fundamental operator's thinking mechanism especially 'situation understanding' are proposed, and the proposals are evaluated by experiments using a full-scale simulator. The results reveal that some assumptions such as 'communication is done between a leader and a follower' are almost appropriate and that the situation understanding can be represented by 'probable candidates for cause, determination of a parameter which changes when an event occurs, determination of parameters which are influenced by the change of the previous parameter, determination of a principal parameter and future prediction of the principal parameter'. (author)

  14. Predictability and possible earlier awareness of extreme precipitation across Europe

    Science.gov (United States)

    Lavers, David; Pappenberger, Florian; Richardson, David; Zsoter, Ervin

    2017-04-01

    Extreme hydrological events can cause large socioeconomic damages in Europe. In winter, a large proportion of these flood episodes are associated with atmospheric rivers, a region of intense water vapour transport within the warm sector of extratropical cyclones. When preparing for such extreme events, forecasts of precipitation from numerical weather prediction models or river discharge forecasts from hydrological models are generally used. Given the strong link between water vapour transport (integrated vapour transport IVT) and heavy precipitation, it is possible that IVT could be used to warn of extreme events. Furthermore, as IVT is located in extratropical cyclones, it is hypothesized to be a more predictable variable due to its link with synoptic-scale atmospheric dynamics. In this research, we firstly provide an overview of the predictability of IVT and precipitation forecasts, and secondly introduce and evaluate the ECMWF Extreme Forecast Index (EFI) for IVT. The EFI is a tool that has been developed to evaluate how ensemble forecasts differ from the model climate, thus revealing the extremeness of the forecast. The ability of the IVT EFI to capture extreme precipitation across Europe during winter 2013/14, 2014/15, and 2015/16 is presented. The results show that the IVT EFI is more capable than the precipitation EFI of identifying extreme precipitation in forecast week 2 during forecasts initialized in a positive North Atlantic Oscillation (NAO) phase. However, the precipitation EFI is superior during the negative NAO phase and at shorter lead times. An IVT EFI example is shown for storm Desmond in December 2015 highlighting its potential to identify upcoming hydrometeorological extremes.

  15. THE PROPOSED MODEL OF COLLABORATIVE VIRTUAL LEARNING ENVIRONMENT FOR INTRODUCTORY PROGRAMMING COURSE

    Directory of Open Access Journals (Sweden)

    Mahfudzah OTHMAN

    2012-01-01

    Full Text Available This paper discusses the proposed model of the collaborative virtual learning system for the introductory computer programming course which uses one of the collaborative learning techniques known as the “Think-Pair-Share”. The main objective of this study is to design a model for an online learning system that facilitates the collaborative learning activities in a virtual environment such as online communications and pair or small group discussions. In order to model the virtual learning environment, the RUP methodology has been used where it involves the data collection phase and the analysis and design phase. Fifty respondents have been randomly selected to participate in the data collection phase to investigate the students’ interest and learning styles as well as their learning preferences. The results have shown the needs for the development of online small group discussions that can be used as an alternative learning style for programming courses. The proposed design of the virtual learning system named as the Online Collaborative Learning System or OCLS is being depicted using the object-oriented models which are the use-case model and class diagram in order to show the concise processes of virtual “Think-Pair-Share” collaborative activities. The “Think-Pair-Share” collaborative learning technique that is being used in this model has been chosen because of its simplicity and relatively low-risk. This paper also presents the proposed model of the system’s architecture that will become the guidelines for the physical development of OCLS using the web-based applications.

  16. THEORETICAL AND EXPERIMENTAL CONTRIBUTIONS CONCERNING THE PROPOSED MODEL FOR THE DISC-TYPED ROTARY ULTRASONIC MOTOR

    Directory of Open Access Journals (Sweden)

    Oana CHIVU

    2010-10-01

    Full Text Available In this work the proposed model for type-disk, ultrasonic motor rotating, elliptic movement to surface beam. A sinusoidal vibration of the vertical displacement in the z-direction, Assume that the vertical displacement of the neutral plane, equals the product of the slope of the neutral plane and half of the beam height, the tangential velocity vs at the upper surface is given.

  17. Proposal of a Modelling of the Innovation Process in an International Manufacturing Company

    Directory of Open Access Journals (Sweden)

    Pauline Lacom

    2017-07-01

    Full Text Available Nowadays, to cope with the competition, and to ensure the durability of their activities, companies have to be able to innovate. Manufacturing companies operating in a B2B market often perceive innovation as a technological result. However, innovation is often more characterized as a process. The needs of the users, and not only the technology, can achieve innovation. In this context, our paper intends to determine how to involve better the users in the innovation process of an international manufacturing company, which is, according to us, representative of the current manufacturing companies. The aim of our research paper is to help manufacturing companies to manage innovation led by users, and to implement their innovation process so that they will be able to set up specific tools for each action of the process. The study proposes a diagram-based language Structured Analysis and Design Technique (SADT that is based on the normative guide FD X50-271 of the French national organization for standardization (AFNOR. The SADT model we propose usefully complements this guide, to make the innovation process more understandable, practical and operational, for manufacturing companies, which are often helpless when faced with the subject. A critical analysis of the model we propose completed in a manufacturing company through semi-structured interviews of the innovation team and questionnaire for all the employees shows the application of the model in the company.

  18. Stress, autonomic imbalance, and the prediction of metabolic risk: A model and a proposal for research.

    Science.gov (United States)

    Wulsin, Lawson; Herman, James; Thayer, Julian F

    2018-03-01

    Devising novel prevention strategies for metabolic disorders will depend in part on the careful elucidation of the common pathways for developing metabolic risks. The neurovisceral integration model has proposed that autonomic imbalance plays an important role in the pathway from acute and chronic stress to cardiovascular disease. Though generally overlooked by clinicians, autonomic imbalance (sympathetic overactivity and/or parasympathetic underactivity) can be measured and modified by methods that are available in primary care. This review applies the neurovisceral integration concept to the clinical setting by proposing that autonomic imbalance plays a primary role in the development of metabolic risks. We present a testable model, a systematic review of the evidence in support of autonomic imbalance as a predictor for metabolic risks, and specific approaches to test this model as a guide to future research on the role of stress in metabolic disorders. We propose that autonomic imbalance deserves consideration by researchers, clinicians, and policymakers as a target for early interventions to prevent metabolic disorders. Published by Elsevier Ltd.

  19. A proposed defect tracking model for classifying the inserted defect reports to enhance software quality control.

    Science.gov (United States)

    Sultan, Torky; Khedr, Ayman E; Sayed, Mostafa

    2013-01-01

    NONE DECLARED Defect tracking systems play an important role in the software development organizations as they can store historical information about defects. There are many research in defect tracking models and systems to enhance their capabilities to be more specifically tracking, and were adopted with new technology. Furthermore, there are different studies in classifying bugs in a step by step method to have clear perception and applicable method in detecting such bugs. This paper shows a new proposed defect tracking model for the purpose of classifying the inserted defects reports in a step by step method for more enhancement of the software quality.

  20. Elders recall an earlier tsunami on Indian Ocean shores

    Science.gov (United States)

    Kakar, Din Mohammad; Naeem, Ghazala; Usman, Abdullah; Hasan, Haider; Lohdi, Hira; Srinivasalu, Seshachalam; Andrade, Vanessa; Rajendran, C.P.; Naderi Beni, Abdolmajid; Hamzeh, Mohammad Ali; Hoffmann, Goesta; Al Balushi, Noora; Gale, Nora; Kodijat, Ardito; Fritz, Hermann M.; Atwater, Brian F.

    2014-01-01

    Ten years on, the Indian Ocean tsunami of 26 December 2004 still looms large in efforts to reduce coastal risk. The disaster has spurred worldwide advances in tsunami detection and warning, tsunami-risk assessment, and tsunami awareness [Satake, 2014]. Nearly a lifetime has passed since the northwestern Indian Ocean last produced a devastating tsunami. Documentation of this tsunami, in November 1945, was hindered by international instability in the wake of the Second World War and, in British India, by the approach of independence and partition. The parent earthquake, of magnitude 8.1, was widely recorded, and the tsunami registered on tide gauges, but intelligence reports and newspaper articles say little about inundation limits while permitting a broad range of catalogued death tolls. What has been established about the 1945 tsunami falls short of what's needed today for ground-truthing inundation models, estimating risk to enlarged populations, and anchoring awareness campaigns in local facts. Recent efforts to reduce coastal risk around the Arabian Sea include a project in which eyewitnesses to the 1945 tsunami were found and interviewed (Fig. 1), and related archives were gathered. Results are being made available through UNESCO's Indian Ocean Tsunami Information Center in hopes of increasing scientific understanding and public awareness of the region's tsunami hazards.

  1. [Impact of small-area context on health: proposing a conceptual model].

    Science.gov (United States)

    Voigtländer, S; Mielck, A; Razum, O

    2012-11-01

    Recent empirical studies stress the impact of features related to the small-area context on individual health. However, so far there exists no standard explanatory model that integrates the different kinds of such features and that conceptualises their relation to individual characteristics of social inequality. A review of theoretical publications on the relationship between social position and health as well as existing conceptual models for the impact of features related to the small-area context on health was undertaken. In the present article we propose a conceptual model for the health impact of the small-area context. This model conceptualises the location of residence as one dimension of social inequality that affects health through the resources as well as stressors which are inherent in the small-area context. The proposed conceptual model offers an orientation for future empirical studies and can serve as a basis for further discussions concerning the health relevance of the small-area context. © Georg Thieme Verlag KG Stuttgart · New York.

  2. Assessment of nutritional status in the elderly: a proposed function-driven model.

    Science.gov (United States)

    Engelheart, Stina; Brummer, Robert

    2018-01-01

    There is no accepted or standardized definition of 'malnutrition'. Hence, there is also no definition of what constitutes an adequate nutritional status. In elderly people, assessment of nutritional status is complex and is complicated by multi-morbidity and disabilities combined with nutrition-related problems, such as dysphagia, decreased appetite, fatigue, and muscle weakness. We propose a nutritional status model that presents nutritional status from a comprehensive functional perspective. This model visualizes the complexity of the nutritional status in elderly people. The presented model could be interpreted as the nutritional status is conditional to a person's optimal function or situation. Another way of looking at it might be that a person's nutritional status affects his or her optimal situation. The proposed model includes four domains: (1) physical function and capacity; (2) health and somatic disorders; (3) food and nutrition; and (4) cognitive, affective, and sensory function. Each domain has a major impact on nutritional status, which in turn has a major impact on the outcome of each domain. Nutritional status is a multifaceted concept and there exist several knowledge gaps in the diagnosis, prevention, and optimization of treatment of inadequate nutritional status in elderly people. The nutritional status model may be useful in nutritional assessment research, as well as in the clinical setting.

  3. A proposed model of psychodynamic psychotherapy linked to Erik Erikson's eight stages of psychosocial development.

    Science.gov (United States)

    Knight, Zelda Gillian

    2017-09-01

    Just as Freud used stages of psychosexual development to ground his model of psychoanalysis, it is possible to do the same with Erik Erikson's stages of development with regards to a model of psychodynamic psychotherapy. This paper proposes an eight-stage model of psychodynamic psychotherapy linked to Erik Erikson's eight stages of psychosocial development. Various suggestions are offered. One such suggestion is that as each of Erikson's developmental stages is triggered by a crisis, in therapy it is triggered by the client's search. The resolution of the search often leads to the development of another search, which implies that the therapy process comprises a series of searches. This idea of a series of searches and resolutions leads to the understanding that identity is developmental and therapy is a space in which a new sense of identity may emerge. The notion of hope is linked to Erikson's stage of Basic Trust and the proposed model of therapy views hope and trust as essential for the therapy process. Two clinical vignettes are offered to illustrate these ideas. Psychotherapy can be approached as an eight-stage process and linked to Erikson's eight stages model of development. Psychotherapy may be viewed as a series of searches and thus as a developmental stage resolution process, which leads to the understanding that identity is ongoing throughout the life span. Copyright © 2017 John Wiley & Sons, Ltd.

  4. Energetic models: a proposal of integrated planning; Modelos energeticos: uma proposta de planejamento integrado

    Energy Technology Data Exchange (ETDEWEB)

    Pereira Junior, Amaro Olimpio; Soares, Jeferson Borghetti; Araujo, Mauro Almeida [Empresa de Pesquisa Energetica (EPE), Brasilia, DF (Brazil)]. E-mails: amaro.pereira@epe.gov.br; jeferson.soares@epe.gov.br; mauro.almeida@epe.gov.br; La Rovere, Emilio Lebre [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Coordenacao dos Programas de Pos-Graduacao de Engenharia. Programa de Planejamento Estrategico]. E-mail: emilio@ppe.ufrj.br; Costa, Ricardo Cunha da [Banco Nacional de Desenvolvimento Economico e Social (BNDES), Rio de Janeiro, RJ (Brazil)]. E-mail: rcco@bndes.gov.br

    2006-07-01

    Top-down, bottom-up and hybrid models for representing energy system are often used in energy planning. However, in developing countries some of their assumptions do not apply: markets are not developed and not competitive; informal economies are representative; there are huge social inequalities; regulatory changes are not completed; there exist constraints to capital flow; etc. All theses problems need to be well represented in order to have energy analysis more consistent. In this work, it is proposed a multi-sector dynamic recursive model that incorporates consumer behaviors, energy policies, technical progress and factors of production substitution. The static result feeds detailed energy models that provide updated values for the next step equilibrium. This approach takes advantages not only in terms of computation but also in terms of the consistence between economy and energy modeling. (author)

  5. Money Earlier or Later? Simple Heuristics Explain Intertemporal Choices Better than Delay Discounting1

    Science.gov (United States)

    Marzilli Ericson, Keith M.; White, John Myles; Laibson, David; Cohen, Jonathan D.

    2015-01-01

    Heuristic models have been proposed for many domains of choice. We compare heuristic models of intertemporal choice, which can account for many of the known intertemporal choice anomalies, to discounting models. We conduct an out-of-sample, cross-validated comparison of intertemporal choice models. Heuristic models outperform traditional utility discounting models, including models of exponential and hyperbolic discounting. The best performing models predict choices by using a weighted average of absolute differences and relative (percentage) differences of the attributes of the goods in a choice set. We conclude that heuristic models explain time-money tradeoff choices in experiments better than utility discounting models. PMID:25911124

  6. Effects of earlier sea ice breakup on survival and population size of polar bears in western Hudson Bay

    Science.gov (United States)

    Regehr, E.V.; Lunn, N.J.; Amstrup, Steven C.; Stirling, I.

    2007-01-01

    Some of the most pronounced ecological responses to climatic warming are expected to occur in polar marine regions, where temperature increases have been the greatest and sea ice provides a sensitive mechanism by which climatic conditions affect sympagic (i.e., with ice) species. Population-level effects of climatic change, however, remain difficult to quantify. We used a flexible extension of Cormack-Jolly-Seber capture-recapture models to estimate population size and survival for polar bears (Ursus maritimus), one of the most ice-dependent of Arctic marine mammals. We analyzed data for polar bears captured from 1984 to 2004 along the western coast of Hudson Bay and in the community of Churchill, Manitoba, Canada. The Western Hudson Bay polar bear population declined from 1,194 (95% CI = 1,020-1,368) in 1987 to 935 (95% CI = 794-1,076) in 2004. Total apparent survival of prime-adult polar bears (5-19 yr) was stable for females (0.93; 95% CI = 0.91-0.94) and males (0.90; 95% CI = 0.88-0.91). Survival of juvenile, subadult, and senescent-adult polar bears was correlated with spring sea ice breakup date, which was variable among years and occurred approximately 3 weeks earlier in 2004 than in 1984. We propose that this correlation provides evidence for a causal association between earlier sea ice breakup (due to climatic warming) and decreased polar bear survival. It may also explain why Churchill, like other communities along the western coast of Hudson Bay, has experienced an increase in human-polar bear interactions in recent years. Earlier sea ice breakup may have resulted in a larger number of nutritionally stressed polar bears, which are encroaching on human habitations in search of supplemental food. Because western Hudson Bay is near the southern limit of the species' range, our findings may foreshadow the demographic responses and management challenges that more northerly polar bear populations will experience if climatic warming in the Arctic continues as

  7. Citygml and the Streets of New York - a Proposal for Detailed Street Space Modelling

    Science.gov (United States)

    Beil, C.; Kolbe, T. H.

    2017-10-01

    Three-dimensional semantic city models are increasingly used for the analysis of large urban areas. Until now the focus has mostly been on buildings. Nonetheless many applications could also benefit from detailed models of public street space for further analysis. However, there are only few guidelines for representing roads within city models. Therefore, related standards dealing with street modelling are examined and discussed. Nearly all street representations are based on linear abstractions. However, there are many use cases that require or would benefit from the detailed geometrical and semantic representation of street space. A variety of potential applications for detailed street space models are presented. Subsequently, based on related standards as well as on user requirements, a concept for a CityGML-compliant representation of street space in multiple levels of detail is developed. In the course of this process, the CityGML Transportation model of the currently valid OGC standard CityGML2.0 is examined to discover possibilities for further developments. Moreover, a number of improvements are presented. Finally, based on open data sources, the proposed concept is implemented within a semantic 3D city model of New York City generating a detailed 3D street space model for the entire city. As a result, 11 thematic classes, such as roadbeds, sidewalks or traffic islands are generated and enriched with a large number of thematic attributes.

  8. [Social determinants of odontalgia in epidemiological studies: theoretical review and proposed conceptual model].

    Science.gov (United States)

    Bastos, João Luiz Dornelles; Gigante, Denise Petrucci; Peres, Karen Glazer; Nedel, Fúlvio Borges

    2007-01-01

    The epidemiological literature has been limited by the absence of a theoretical framework reflecting the complexity of causal mechanisms for the occurrence of health phenomena / disease conditions. In the field of oral epidemiology, such lack of theory also prevails, since dental caries the leading topic in oral research has been often studied through a biological and reductionist viewpoint. One of the most important consequences of dental caries is dental pain (odontalgia), which has received little attention in studies with sophisticated theoretical models and powerful designs to establish causal relationships. The purpose of this study is to review the scientific literature on the determinants of odontalgia and to discuss theories proposed for the explanation of the phenomenon. Conceptual models and emerging theories on the social determinants of oral health are revised, in an attempt to build up links with the bio-psychosocial pain model, proposing a more elaborate causal model for odontalgia. The framework suggests causal pathways between social structure and oral health through material, psychosocial and behavioral pathways. Aspects of the social structure are highlighted in order to relate them to odontalgia, stressing their importance in discussions of causal relationships in oral health research.

  9. Proposal of custom made wrist orthoses based on 3D modelling and 3D printing.

    Science.gov (United States)

    Abreu de Souza, Mauren; Schmitz, Cristiane; Marega Pinhel, Marcelo; Palma Setti, Joao A; Nohama, Percy

    2017-07-01

    Accessibility to three-dimensional (3D) technologies, such as 3D scanning systems and additive manufacturing (like 3D printers), allows a variety of 3D applications. For medical applications in particular, these modalities are gaining a lot of attention enabling several opportunities for healthcare applications. The literature brings several cases applying both technologies, but none of them focus on the spreading of how this technology could benefit the health segment. This paper proposes a new methodology, which employs both 3D modelling and 3D printing for building orthoses, which could better fit the demands of different patients. Additionally, there is an opportunity for sharing expertise, as it represents a trendy in terms of the maker-movement. Therefore, as a result of the proposed approach, we present a case study based on a volunteer who needs an immobilization orthosis, which was built for exemplification of the whole process. This proposal also employs freely available 3D models and software, having a strong social impact. As a result, it enables the implementation and effective usability for a variety of built to fit solutions, hitching useful and smarter technologies for the healthcare sector.

  10. Money earlier or later? Simple heuristics explain intertemporal choices better than delay discounting does.

    Science.gov (United States)

    Ericson, Keith M Marzilli; White, John Myles; Laibson, David; Cohen, Jonathan D

    2015-06-01

    Heuristic models have been proposed for many domains involving choice. We conducted an out-of-sample, cross-validated comparison of heuristic models of intertemporal choice (which can account for many of the known intertemporal choice anomalies) and discounting models. Heuristic models outperformed traditional utility-discounting models, including models of exponential and hyperbolic discounting. The best-performing models predicted choices by using a weighted average of absolute differences and relative percentage differences of the attributes of the goods in a choice set. We concluded that heuristic models explain time-money trade-off choices in experiments better than do utility-discounting models. © The Author(s) 2015.

  11. A Proposed Analytical Model for Integrated Pick-and-Sort Systems

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    Recep KIZILASLAN

    2013-11-01

    Full Text Available In this study we present an analytical approach for integration of order picking and sortation operations which are the most important, labour intensive and costly activity for warehouses. Main aim is to investigate order picking and sorting efficiencies under different design issues as a function of order wave size. Integrated analytical model is proposed to estimate the optimum order picking and order sortation efficiency. The model, which has been tested by simulations with different illustrative examples, calculates the optimum wave size that solves the trade-off between picking and sorting operations and makes the order picking and sortations efficiency maximum. Our model also allow system designer to predict the order picking and sorting capacity for different system configurations. This study presents an innovative approach for integrated warehouse operations.

  12. Nanometrology, Standardization and Regulation of Nanomaterials in Brazil: A Proposal for an Analytical-Prospective Model

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    Ana Rusmerg Giménez Ledesma

    2013-05-01

    Full Text Available The main objective of this paper is to propose an analytical-prospective model as a tool to support decision-making processes concerning metrology, standardization and regulation of nanomaterials in Brazil, based on international references and ongoing initiatives in the world. In the context of nanotechnology development in Brazil, the motivation for carrying out this research was to identify potential benefits of metrology, standardization and regulation of nanomaterials production, from the perspective of future adoption of the model by the main stakeholders of development of these areas in Brazil. The main results can be summarized as follows: (i an overview of international studies on metrology, standardization and regulation of nanomaterials, and nanoparticles, in special; (ii the analytical-prospective model; and (iii the survey questionnaire and the roadmapping tool for metrology, standardization and regulation of nanomaterials in Brazil, based on international references and ongoing initiatives in the world.

  13. Proposed model for fuel-coolant mixing during a core-melt accident

    International Nuclear Information System (INIS)

    Corradini, M.L.

    1983-01-01

    If complete failure of normal and emergency coolant flow occurs in a light water reactor, fission product decay heat would eventually cause melting of the reactor fuel and cladding. The core melt may then slump into the lower plenum and later into the reactor cavity and contact residual liquid water. A model is proposed to describe the fuel-coolant mixing process upon contact. The model is compared to intermediate scale experiments being conducted at Sandia. The modelling of this mixing process will aid in understanding three important processes: (1) fuel debris sizes upon quenching in water, (2) the hydrogen source term during fuel quench, and (3) the rate of steam production. Additional observations of Sandia data indicate that the steam explosion is affected by this mixing process

  14. Proposal of a congestion control technique in LAN networks using an econometric model ARIMA

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    Joaquín F Sánchez

    2017-01-01

    Full Text Available Hasty software development can produce immediate implementations with source code unnecessarily complex and hardly readable. These small kinds of software decay generate a technical debt that could be big enough to seriously affect future maintenance activities. This work presents an analysis technique for identifying architectural technical debt related to non-uniformity of naming patterns; the technique is based on term frequency over package hierarchies. The proposal has been evaluated on projects of two popular organizations, Apache and Eclipse. The results have shown that most of the projects have frequent occurrences of the proposed naming patterns, and using a graph model and aggregated data could enable the elaboration of simple queries for debt identification. The technique has features that favor its applicability on emergent architectures and agile software development.

  15. Organizational intellectual capital and the role of the nurse manager: A proposed conceptual model.

    Science.gov (United States)

    Gilbert, Jason H; Von Ah, Diane; Broome, Marion E

    Nurse managers must leverage both the human capital and social capital of the teams they lead in order to produce quality outcomes. Little is known about the relationship between human capital and social capital and how these concepts may work together to produce organizational outcomes through leadership of nurses. The purpose of this article was to explore the concepts of human capital and social capital as they relate to nursing leadership in health care organizations. Specific aims included (a) to synthesize the literature related to human capital and social capital in leadership, (b) to refine the conceptual definitions of human capital and social capital with associated conceptual antecedents and consequences, and (c) to propose a synthesized conceptual model guiding further empirical research of social capital and human capital in nursing leadership. A systematic integrative review of leadership literature using criteria informed by Whittemore and Knafl (2005) was completed. CINAHL Plus with Full Text, Academic Search Premier, Business Source Premier, Health Business FullTEXT, MEDLINE, and PsychINFO databases were searched for the years 1995 to 2016 using terms "human capital," "social capital," and "management." Analysis of conceptual definitions, theoretical and conceptual models, antecedents and consequences, propositions or hypotheses, and empirical support for 37 articles fitting review criteria resulted in the synthesis of the proposed Gilbert Conceptual Model of Organizational Intellectual Capital. The Gilbert Conceptual Model of Organizational Intellectual Capital advances the propositions of human capital theory and social capital theory and is the first model to conceptualize the direct and moderating effects that nurse leaders have on the human capital and social capital of the teams they lead. This model provides a framework for further empirical study and may have implications for practice, organizational policy, and education related to nursing

  16. Proposal for a model for competitiveness analysis in environmental sustainability in automotive segment companies

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    Luís Henrique Rodrigues

    2018-06-01

    Full Text Available The competitive landscape for companies has been changing over time, featuring an increase in competitiveness in cost, quality, reliability, agility and more recently by a concern for environmental and social factors. This work aims to propose an exploratory analysis model to evaluate companies’ sustainability competitiveness. The model proposes the grouping of companies into clusters, ranking them according to the adoption of lean manufacturing practices, environmental management and human resources, and allocating them into quadrants according to the higher or lower production of waste in their manufacturing processes. The adherence to the model is made with a sample of automotive segment companies (auto parts and motor vehicle manufacturers. The work is classified as one of a practical nature, exploratory, qualitative, and using the survey method. The conclusion that 37.5% of auto parts companies are grouped into clusters that lead to the reduction of waste, with practices in lean manufacturing and environmental management which adjust to competitive factors in the sustainability of motor vehicle manufacturers, is noteworthy.

  17. Modeling fault rupture hazard for the proposed repository at Yucca Mountain, Nevada

    International Nuclear Information System (INIS)

    Coppersmith, K.J.; Youngs, R.R.

    1992-01-01

    In this paper as part of the Electric Power Research Institute's High Level Waste program, the authors have developed a preliminary probabilistic model for assessing the hazard of fault rupture to the proposed high level waste repository at Yucca Mountain. The model is composed of two parts: the earthquake occurrence model that describes the three-dimensional geometry of earthquake sources and the earthquake recurrence characteristics for all sources in the site vicinity; and the rupture model that describes the probability of coseismic fault rupture of various lengths and amounts of displacement within the repository horizon 350 m below the surface. The latter uses empirical data from normal-faulting earthquakes to relate the rupture dimensions and fault displacement amounts to the magnitude of the earthquake. using a simulation procedure, we allow for earthquake occurrence on all of the earthquake sources in the site vicinity, model the location and displacement due to primary faults, and model the occurrence of secondary faulting in conjunction with primary faulting

  18. Earlier time to aerobic exercise is associated with faster recovery following acute sport concussion.

    Science.gov (United States)

    Lawrence, David Wyndham; Richards, Doug; Comper, Paul; Hutchison, Michael G

    2018-01-01

    To determine whether earlier time to initiation of aerobic exercise following acute concussion is associated with time to full return to (1) sport and (2) school or work. A retrospective stratified propensity score survival analysis of acute (≤14 days) concussion was used to determine whether time (days) to initiation of aerobic exercise post-concussion was associated with, both, time (days) to full return to (1) sport and (2) school or work. A total of 253 acute concussions [median (IQR) age, 17.0 (15.0-20.0) years; 148 (58.5%) males] were included in this study. Multivariate Cox regression models identified that earlier time to aerobic exercise was associated with faster return to sport and school/work adjusting for other covariates, including quintile propensity strata. For each successive day in delay to initiation of aerobic exercise, individuals had a less favourable recovery trajectory. Initiating aerobic exercise at 3 and 7 days following injury was associated with a respective 36.5% (HR, 0.63; 95% CI, 0.53-0.76) and 73.2% (HR, 0.27; 95% CI, 0.16-0.45) reduced probability of faster full return to sport compared to within 1 day; and a respective 45.9% (HR, 0.54; 95% CI, 0.44-0.66) and 83.1% (HR, 0.17; 95% CI, 0.10-0.30) reduced probability of faster full return to school/work. Additionally, concussion history, symptom severity, LOC deleteriously influenced concussion recovery. Earlier initiation of aerobic exercise was associated with faster full return to sport and school or work. This study provides greater insight into the benefits and safety of aerobic exercise within the first week of the injury.

  19. Proposed Core Competencies and Empirical Validation Procedure in Competency Modeling: Confirmation and Classification.

    Science.gov (United States)

    Baczyńska, Anna K; Rowiński, Tomasz; Cybis, Natalia

    2016-01-01

    Competency models provide insight into key skills which are common to many positions in an organization. Moreover, there is a range of competencies that is used by many companies. Researchers have developed core competency terminology to underline their cross-organizational value. The article presents a theoretical model of core competencies consisting of two main higher-order competencies called performance and entrepreneurship. Each of them consists of three elements: the performance competency includes cooperation, organization of work and goal orientation, while entrepreneurship includes innovativeness, calculated risk-taking and pro-activeness. However, there is lack of empirical validation of competency concepts in organizations and this would seem crucial for obtaining reliable results from organizational research. We propose a two-step empirical validation procedure: (1) confirmation factor analysis, and (2) classification of employees. The sample consisted of 636 respondents (M = 44.5; SD = 15.1). Participants were administered a questionnaire developed for the study purpose. The reliability, measured by Cronbach's alpha, ranged from 0.60 to 0.83 for six scales. Next, we tested the model using a confirmatory factor analysis. The two separate, single models of performance and entrepreneurial orientations fit quite well to the data, while a complex model based on the two single concepts needs further research. In the classification of employees based on the two higher order competencies we obtained four main groups of employees. Their profiles relate to those found in the literature, including so-called niche finders and top performers. Some proposal for organizations is discussed.

  20. A Proposed Model for Selecting Measurement Procedures for the Assessment and Treatment of Problem Behavior.

    Science.gov (United States)

    LeBlanc, Linda A; Raetz, Paige B; Sellers, Tyra P; Carr, James E

    2016-03-01

    Practicing behavior analysts frequently assess and treat problem behavior as part of their ongoing job responsibilities. Effective measurement of problem behavior is critical to success in these activities because some measures of problem behavior provide more accurate and complete information about the behavior than others. However, not every measurement procedure is appropriate for every problem behavior and therapeutic circumstance. We summarize the most commonly used measurement procedures, describe the contexts for which they are most appropriate, and propose a clinical decision-making model for selecting measurement produces given certain features of the behavior and constraints of the therapeutic environment.

  1. Proposal of Constraints Analysis Method Based on Network Model for Task Planning

    Science.gov (United States)

    Tomiyama, Tomoe; Sato, Tatsuhiro; Morita, Toyohisa; Sasaki, Toshiro

    Deregulation has been accelerating several activities toward reengineering business processes, such as railway through service and modal shift in logistics. Making those activities successful, business entities have to regulate new business rules or know-how (we call them ‘constraints’). According to the new constraints, they need to manage business resources such as instruments, materials, workers and so on. In this paper, we propose a constraint analysis method to define constraints for task planning of the new business processes. To visualize each constraint's influence on planning, we propose a network model which represents allocation relations between tasks and resources. The network can also represent task ordering relations and resource grouping relations. The proposed method formalizes the way of defining constraints manually as repeatedly checking the network structure and finding conflicts between constraints. Being applied to crew scheduling problems shows that the method can adequately represent and define constraints of some task planning problems with the following fundamental features, (1) specifying work pattern to some resources, (2) restricting the number of resources for some works, (3) requiring multiple resources for some works, (4) prior allocation of some resources to some works and (5) considering the workload balance between resources.

  2. From representing to modelling knowledge: Proposing a two-step training for excellence in concept mapping

    Directory of Open Access Journals (Sweden)

    Joana G. Aguiar

    2017-09-01

    Full Text Available Training users in the concept mapping technique is critical for ensuring a high-quality concept map in terms of graphical structure and content accuracy. However, assessing excellence in concept mapping through structural and content features is a complex task. This paper proposes a two-step sequential training in concept mapping. The first step requires the fulfilment of low-order cognitive objectives (remember, understand and apply to facilitate novices’ development into good Cmappers by honing their knowledge representation skills. The second step requires the fulfilment of high-order cognitive objectives (analyse, evaluate and create to grow good Cmappers into excellent ones through the development of knowledge modelling skills. Based on Bloom’s revised taxonomy and cognitive load theory, this paper presents theoretical accounts to (1 identify the criteria distinguishing good and excellent concept maps, (2 inform instructional tasks for concept map elaboration and (3 propose a prototype for training users on concept mapping combining online and face-to-face activities. The proposed training application and the institutional certification are the next steps for the mature use of concept maps for educational as well as business purposes.

  3. APC-PC Combined Scheme in Gilbert Two State Model: Proposal and Study

    Science.gov (United States)

    Bulo, Yaka; Saring, Yang; Bhunia, Chandan Tilak

    2017-04-01

    In an automatic repeat request (ARQ) scheme, a packet is retransmitted if it gets corrupted due to transmission errors caused by the channel. However, an erroneous packet may contain both erroneous bits and correct bits and hence it may still contain useful information. The receiver may be able to combine this information from multiple erroneous copies to recover the correct packet. Packet combining (PC) is a simple and elegant scheme of error correction in transmitted packet, in which two received copies are XORed to obtain the bit location of erroneous bits. Thereafter, the packet is corrected by bit inversion of bit located as erroneous. Aggressive packet combining (APC) is a logic extension of PC primarily designed for wireless communication with objective of correcting error with low latency. PC offers higher throughput than APC, but PC does not correct double bit errors if occur in same bit location of erroneous copies of the packet. A hybrid technique is proposed to utilize the advantages of both APC and PC while attempting to remove the limitation of both. In the proposed technique, applications of APC-PC on Gilbert two state model has been studied. The simulation results show that the proposed technique offers better throughput than the conventional APC and lesser packet error rate than PC scheme.

  4. The Uses and Dependency Model of Mass Communication.

    Science.gov (United States)

    Rubin, Alan M.; Windahl, Sven

    1986-01-01

    Responds to criticism of the uses and gratification model by proposing a modified model integrating the dependency perspective. Suggests that this integrated model broadens the heuristic application of the earlier model. (MS)

  5. A model proposal concerning balance scorecard application integrated with resource consumption accounting in enterprise performance management

    Directory of Open Access Journals (Sweden)

    ORHAN ELMACI

    2014-06-01

    Full Text Available The present study intended to investigate the “Balance Scorecard (BSC model integrated with Resource Consumption Accounting (RCA” which helps to evaluate the enterprise as matrix structure in its all parts. It aims to measure how much tangible and intangible values (assets of enterprises contribute to the enterprises. In other words, it measures how effectively, actively, and efficiently these values (assets are used. In short, it aims to measure sustainable competency of enterprises. As expressing the effect of tangible and intangible values (assets of the enterprise on the performance in mathematical and statistical methods is insufficient, it is targeted that RCA Method integrated with BSC model is based on matrix structure and control models. The effects of all complex factors in the enterprise on the performance (productivity and efficiency estimated algorithmically with cause and effect diagram. The contributions of matrix structures for reaching the management functional targets of the enterprises that operate in market competitive environment increasing day to day, is discussed. So in the context of modern management theories, as a contribution to BSC approach which is in the foreground in today’s administrative science of enterprises in matrix organizational structures, multidimensional performance evaluation model -RCA integrated with BSC Model proposal- is presented as strategic planning and strategic evaluation instrument.

  6. A Proposed Model for Measuring Performance of the University-Industry Collaboration in Open Innovation

    Directory of Open Access Journals (Sweden)

    Anca Draghici

    2017-06-01

    Full Text Available The paper aims to present a scientific approach to the creation, testing and validation of a model for performance measurement for university-industry collaboration (UIC. The main idea of the design process is to capitalize on existing success factors, facilitators and opportunities (motivation factors, knowledge transfer channels and identified benefits and to diminish or avoid potential threats and barriers that might interfere with such collaborations. The main purpose of the applied methodology is to identify solutions and measures to overcome the disadvantages, conflicts or risk issues and to facilitate the open innovation of industrial companies and universities. The methodology adopted was differentiated by two perspectives: (1 a business model reflecting the university perspective along with an inventory of key performance indicators (KPIs; (2 a performance measurement model (including performance criteria and indicators and an associated methodology (assimilated to an audit that could help companies increase collaboration with universities in the context of open innovation. In addition, in order to operationalize the proposed model (facilitating practical implementation, an Excel tool has been created to help identifying potential sources of innovation. The main contributions of the research concern the expansion of UICs knowledge to enhance open innovation and to define an effective performance measurement model and instrument (tested and validated by a case study for companies.

  7. The proposed 'concordance-statistic for benefit' provided a useful metric when modeling heterogeneous treatment effects.

    Science.gov (United States)

    van Klaveren, David; Steyerberg, Ewout W; Serruys, Patrick W; Kent, David M

    2018-02-01

    Clinical prediction models that support treatment decisions are usually evaluated for their ability to predict the risk of an outcome rather than treatment benefit-the difference between outcome risk with vs. without therapy. We aimed to define performance metrics for a model's ability to predict treatment benefit. We analyzed data of the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) trial and of three recombinant tissue plasminogen activator trials. We assessed alternative prediction models with a conventional risk concordance-statistic (c-statistic) and a novel c-statistic for benefit. We defined observed treatment benefit by the outcomes in pairs of patients matched on predicted benefit but discordant for treatment assignment. The 'c-for-benefit' represents the probability that from two randomly chosen matched patient pairs with unequal observed benefit, the pair with greater observed benefit also has a higher predicted benefit. Compared to a model without treatment interactions, the SYNTAX score II had improved ability to discriminate treatment benefit (c-for-benefit 0.590 vs. 0.552), despite having similar risk discrimination (c-statistic 0.725 vs. 0.719). However, for the simplified stroke-thrombolytic predictive instrument (TPI) vs. the original stroke-TPI, the c-for-benefit (0.584 vs. 0.578) was similar. The proposed methodology has the potential to measure a model's ability to predict treatment benefit not captured with conventional performance metrics. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Proposing a model for limiting earning management practices: The case of Jordanian listed firms

    Directory of Open Access Journals (Sweden)

    Dea’a Al-Deen Al-Sraheen

    2016-11-01

    Full Text Available The key objective of this paper is to propose a model for limiting earning management practices among manufacturing firms in Jordan. In order to do so, two independent variables are examined in this paper, namely, political influence and CEO Duality. Discretionary total accruals according to the modified Jones model (1991 was used in order to estimate the level of earnings management, which is the dependent variable. The sample comprised 64 companies for the financial year 2013. The results suggest that a positive and significant association existed among both political influence and CEO duality and earning management. This means that both independent variables exacerbated earnings management. Further research is required to determine what urgent legislation should be developed to restrict the presence of members who have political connections on the board of directors. Also, the need exists for the separation of roles of Chairman and CEO to ensure the independence and complying with the requirements of corporate governance.

  9. Proposed Model for Integrating RAMS Method in the Design Process in Construction

    Directory of Open Access Journals (Sweden)

    Saad Al-Jibouri

    2010-05-01

    Full Text Available There is a growing trend in the Netherlands for outsourcing public construction activities to the private sector through the use of integrated contracts. There is also an increasing emphasis from public clients on the use of RAMS and life cycle costing (LCC in the design process of infrastructural projects to improve the performance of designed systems and optimize the project cost. RAMS is an acronym for `reliability, availability, maintainability and safety' and represents a collection of techniques to provide predictions of the performance targets of the required system. Increasingly, RAMS targets are being specified in invitation to tender or contract documents and the parties responsible for the design are required to provide evidence of its application in their design. Recent evidence from practice, complemented with a literature study, has shown that the knowledge and application of RAMS in infrastructural designs are in their infancy compared with other industrial sectors and many designers in construction do not have the necessary knowledge and experience to apply it. This paper describes a proposed model for the integration of RAMS and LCC into the design process in construction. A variation of the model for the application of RAMS in `design, build, finance and maintain' (DBFM contracts that include maintenance requirements is also proposed. The two models involve providing guidelines to simplify the application of RAMs by the designers. The model has been validated for its practicality and usefulness during a workshop by experienced designers. DOI: 10.3763/aedm.2008.0100 Published in the Journal AEDM - Volume 5, Number 4, 2009 , pp. 179-192(14

  10. AN EFFECTIVE RISK-PREVENTIVE MODEL PROPOSAL FOR OCCUPATIONAL ACCIDENTS AT SHIPYARDS

    Directory of Open Access Journals (Sweden)

    Ozge Acuner

    2016-03-01

    Full Text Available According to the statistics of occupational accidents, it is observed that the number of accidents occurred in shipbuilding industry is high and the rate of deaths and serious injuries among these accidents is higher than in other industries. However, the number of the studies to prevent these accidents in both industrial and scientific practices is considerably low. Therefore, the objective of this study is to develop an efficient risk preventive model in accordance with occupational health and safety regulations for industrial organizations. The approach proposed in this study differs from those described in the literature, because it is based on fuzzy set theory in order to cope with uncertainties on probability and severity definitions in terms of occupational health and safety. Furthermore, in this paper, risk severity is considered in terms of harm to worker, harm to environment, and harm to hardware, whereas in the literature, risk severity is generally considered solely in terms of only harm to worker. Then, risk magnitude is obtained by utilizing fuzzy inference system. The proposed approach is applied to a shipyard located in the Marmara Region in order to illustrate the applicability of the model.

  11. Proposed retention model for human inhalation exposure to 241AmO2

    International Nuclear Information System (INIS)

    Mewhinney, J.A.; Griffith, W.C.; Muggenburg, B.A.

    1980-01-01

    A dosimetry model based on a four-year study in Beagle dogs was developed to predict patterns of absorbed radiation doses for people exposed by inhalation to 241 AmO 2 . Following a single inhalation exposure to one of three sizes of monodisperse or a polydisperse aerosol of 241 AmO 2 , pairs of dogs were sacrificed at 8, 32, 64 and 256 days, and 2 and 4 years. For about 80% of the initial lung burden, the retention halftimes were 11, 18, 26 and 27 days for the 0.75, 1.5 and 3.0 μm aerodynamic diameter and the 1.8 μm activity median aerodynamic diameter aerosols, respectively. For the remaining 20% of the initial lung burden, the retention halftimes were between 200 to 300 days with no apparent particle size influence. Additional 241 Am metabolic studies reported in the literature using inhalation exposure or injection of the citrate complex were synthesized in the model as were eleven reported cases of human inhalation exposure. This model is compared to the ICRP II and TGLD lung models, both developed by analogy to Pu metabolism. The proposed model differs from these latter models in two important areas: (a) lung retention of 241 AmO 2 could not be adapted to the classifications used in these models, and (b) the fractional translocation from lung to other organs is 2 to 8 times larger. These factors considerably alter the predicted radiation dose distribution among organs and lead to the conclusion that derived radiation protection standards for 241 AmO 2 inhalation exposure should be modified. (author)

  12. On the scale similarity in large eddy simulation. A proposal of a new model

    International Nuclear Information System (INIS)

    Pasero, E.; Cannata, G.; Gallerano, F.

    2004-01-01

    validity of the proposed model was tested through channel flow simulation with friction-velocity-based Reynolds numbers ranging from 180 to 2340. (author)

  13. Information Systems Success In Public Administration: Proposal For An Exploratory Model

    Directory of Open Access Journals (Sweden)

    Deyvison de Lima Oliveira

    2015-12-01

    Full Text Available Investments in Information Systems (IS have been significantly increasing and hence the relevance of the studies on the IS success is persistent. Delone and Mclean (2003 developed an IS successful model which is a benchmark for researches in the area, however, in the perspective of the public sector, studies are still rare. In this research it was sought to propose an exploratory model of successful IS in public administration, from the identification of each construct items of the Delone and McLean (2003 original model, through multiple case studies in three Municipalities and a Town Hall of the Southern Cone of Rondônia state, in Brazil. Based on the empirical research, it was found that the IS success factors in municipal public administration are close to those factors indicated in the reviewed literature, however, showing some particularities of the public sector. A model of successful factors and items of IS, from the confrontation between literature and empirical data, is presented in the end of this work.

  14. Socio-economic vulnerability to natural hazards - proposal for an indicator-based model

    Science.gov (United States)

    Eidsvig, U.; McLean, A.; Vangelsten, B. V.; Kalsnes, B.; Ciurean, R. L.; Argyroudis, S.; Winter, M.; Corominas, J.; Mavrouli, O. C.; Fotopoulou, S.; Pitilakis, K.; Baills, A.; Malet, J. P.

    2012-04-01

    Vulnerability assessment, with respect to natural hazards, is a complex process that must consider multiple dimensions of vulnerability, including both physical and social factors. Physical vulnerability refers to conditions of physical assets, and may be modeled by the intensity and magnitude of the hazard, the degree of physical protection provided by the natural and built environment, and the physical robustness of the exposed elements. Social vulnerability refers to the underlying factors leading to the inability of people, organizations, and societies to withstand impacts from the natural hazards. Social vulnerability models can be used in combination with physical vulnerability models to estimate both direct losses, i.e. losses that occur during and immediately after the impact, as well as indirect losses, i.e. long-term effects of the event. Direct impact of a landslide typically includes casualties and damages to buildings and infrastructure while indirect losses may e.g. include business closures or limitations in public services. The direct losses are often assessed using physical vulnerability indicators (e.g. construction material, height of buildings), while indirect losses are mainly assessed using social indicators (e.g. economical resources, demographic conditions). Within the EC-FP7 SafeLand research project, an indicator-based method was proposed to assess relative socio-economic vulnerability to landslides. The indicators represent the underlying factors which influence a community's ability to prepare for, deal with, and recover from the damage associated with landslides. The proposed model includes indicators representing demographic, economic and social characteristics as well as indicators representing the degree of preparedness and recovery capacity. Although the model focuses primarily on the indirect losses, it could easily be extended to include more physical indicators which account for the direct losses. Each indicator is individually

  15. A Proposed Model for Assessing Organisational Culture Towards Achieving Business Objectives

    Directory of Open Access Journals (Sweden)

    Hafez Salleh

    2011-09-01

    Full Text Available Most of the traditional business performances measures are based on productivity and process criteria, which mainly focus on method of investment appraisal such as payback method, return on investment (ROI, cost-benefits analysis (CBA, net present value (NPV, internal rate of return (IRR. However, the measurement scales of business performance are not limited to those measures. One element that has strong correlation to the business performances is ‘organisational culture’. Many studies proved that one of the significant criteria for achieving desired business objectives is the right organisational culture within workplace. Basically, the measurement of organisational culture is reflecting on two distinct elements: organisational culture and business objectives. In broader perspective, an organisation is considered effective if it meets its business objectives. This paper aims to present and discuss the preliminary culture model to indicate the culture performance within organisational. The model has been developed through literature review, expert opinion and experience which is anticipated of being able to potentially measure the culture capability of organisations across industries to “successfully achieve business objectives”. The model is composed of six progressive stages of maturity that an organisation can achieve its culture performance. For each maturity stage, the model describes a set of characteristics that must be in place for the company to achieve each stage. The validity of the proposed model will be tested by a few case studies. The idea is to provide managers with a qualitative measurement tools to enable them to identify where culture improvements are required within their organisations and to indicate their readiness for achieving business objectives.

  16. Global model of zenith tropospheric delay proposed based on EOF analysis

    Science.gov (United States)

    Sun, Langlang; Chen, Peng; Wei, Erhu; Li, Qinzheng

    2017-07-01

    Tropospheric delay is one of the main error budgets in Global Navigation Satellite System (GNSS) measurements. Many empirical correction models have been developed to compensate this delay, and models which do not require meteorological parameters have received the most attention. This study established a global troposphere zenith total delay (ZTD) model, called Global Empirical Orthogonal Function Troposphere (GEOFT), based on the empirical orthogonal function (EOF, also known as geographically weighted PCAs) analysis method and the Global Geodetic Observing System (GGOS) Atmosphere data from 2012 to 2015. The results showed that ZTD variation could be well represented by the characteristics of the EOF base function Ek and associated coefficients Pk. Here, E1 mainly signifies the equatorial anomaly; E2 represents north-south asymmetry, and E3 and E4 reflects regional variation. Moreover, P1 mainly reflects annual and semiannual variation components; P2 and P3 mainly contains annual variation components, and P4 displays semiannual variation components. We validated the proposed GEOFT model using tropospheric delay data of GGOS ZTD grid data and the tropospheric product of the International GNSS Service (IGS) over the year 2016. The results showed that GEOFT model has high accuracy with bias and RMS of -0.3 and 3.9 cm, respectively, with respect to the GGOS ZTD data, and of -0.8 and 4.1 cm, respectively, with respect to the global IGS tropospheric product. The accuracy of GEOFT demonstrating that the use of the EOF analysis method to characterize ZTD variation is reasonable.

  17. A proposed centralised distribution model for the South African automotive component industry

    Directory of Open Access Journals (Sweden)

    Micheline J. Naude

    2009-12-01

    Full Text Available Purpose: This article explores the possibility of developing a distribution model, similar to the model developed and implemented by the South African pharmaceutical industry, which could be implemented by automotive component manufacturers for supply to independent retailers. Problem Investigated: The South African automotive components distribution chain is extensive with a number of players of varying sizes, from the larger spares distribution groups to a number of independent retailers. Distributing to the smaller independent retailers is costly for the automotive component manufacturers. Methodology: This study is based on a preliminary study of an explorative nature. Interviews were conducted with a senior staff member from a leading automotive component manufacturer in KwaZulu Natal and nine participants at a senior management level at five of their main customers (aftermarket retailers. Findings: The findings from the empirical study suggest that the aftermarket component industry is mature with the role players well established. The distribution chain to the independent retailer is expensive in terms of transaction and distribution costs for the automotive component manufacturer. A proposed centralised distribution model for supply to independent retailers has been developed which should reduce distribution costs for the automotive component manufacturer in terms of (1 the lowest possible freight rate; (2 timely and controlled delivery; and (3 reduced congestion at the customer's receiving dock. Originality: This research is original in that it explores the possibility of implementing a centralised distribution model for independent retailers in the automotive component industry. Furthermore, there is a dearth of published research on the South African automotive component industry particularly addressing distribution issues. Conclusion: The distribution model as suggested is a practical one and should deliver added value to automotive

  18. MODEL REQUEST FOR PROPOSALS TO PROVIDE ENERGY AND OTHER ATTRIBUTES FROM AN OFFSHORE WIND POWER PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    Jeremy Firestone; Dawn Kurtz Crompton

    2011-10-22

    This document provides a model RFP for new generation. The 'base' RFP is for a single-source offshore wind RFP. Required modifications are noted should a state or utility seek multi-source bids (e.g., all renewables or all sources). The model is premised on proposals meeting threshold requirements (e.g., a MW range of generating capacity and a range in terms of years), RFP issuer preferences (e.g., likelihood of commercial operation by a date certain, price certainty, and reduction in congestion), and evaluation criteria, along with a series of plans (e.g., site, environmental effects, construction, community outreach, interconnection, etc.). The Model RFP places the most weight on project risk (45%), followed by project economics (35%), and environmental and social considerations (20%). However, if a multi-source RFP is put forward, the sponsor would need to either add per-MWh technology-specific, life-cycle climate (CO2), environmental and health impact costs to bid prices under the 'Project Economics' category or it should increase the weight given to the 'Environmental and Social Considerations' category.

  19. A proposed model for assessing service quality in small machining and industrial maintenance companies

    Directory of Open Access Journals (Sweden)

    Morvam dos Santos Netto

    2014-11-01

    Full Text Available Machining and industrial maintenance services include repair (corrective maintenance of equipments, activities involving the assembly-disassembly of equipments, fault diagnosis, machining operations, forming operations, welding processes, assembly and test of equipments. This article proposes a model for assessing the quality of services provided by small machining and industrial maintenance companies, since there is a gap in the literature regarding this issue and because the importance of small service companies in socio-economic development of the country. The model is an adaptation of the SERVQUAL instrument and the criteria determining the quality of services are designed according to the service cycle of a typical small machining and industrial maintenance company. In this sense, the Moments of Truth have been considered in the preparation of two separate questionnaires. The first questionnaire contains 24 statements that reflect the expectations of customers, and the second one contains 24 statements that measure perceptions of service performance. An additional item was included in each questionnaire to assess, respectively, the overall expectation about the services and the overall company performance. Therefore, it is a model that considers the interfaces of the client/supplier relationship, the peculiarities of the machining and industrial maintenance service sector and the company size.

  20. A data envelopment analysis based model for proposing safety improvements: a FMEA approach

    International Nuclear Information System (INIS)

    Garcia, Pauli A. de A.; Barbosa Junior, Gilberto V.; Melo, P.F. Frutuoso e

    2005-01-01

    When performing a probabilistic safety assessment, one important step is the identification of the critical or weak points of all systems to be considered. By properly ranking these critical points, improvement recommendations may be proposed, in order to reduce the associated risks. Many tools are available for the identification of critical points, like the Failure Mode and Effect Analysis (FMEA) and the Hazard and Operability Studies (HAZOP). Once the failure modes or deviations are identified, indices associated to the occurrence probabilities, detection potential, and the effects severity, are assigned to them, and so the failure modes or deviations ranking is performed. It is common practice to assign risk priority numbers for this purpose. These numbers are obtained by multiplying the three aforementioned indices, which typically vary from 1 to 10 (natural numbers). Here, the greater the index, the worst the situation. In this paper, a data envelopment analysis (DEA) based model is used to identify the most critical failure modes or deviations and, by means of their respective distances to the boundary, to assess the improvement percentage for each index of each failure mode or deviation. Starting from this identification procedure, the decision maker can more efficiently propose improvement actions, like reliability allocation, detection design, protective barriers, etc. (author)

  1. Futility Disputes: A Review of the Literature and Proposed Model for Dispute Navigation Through Trust Building.

    Science.gov (United States)

    Leland, Brian D; Torke, Alexia M; Wocial, Lucia D; Helft, Paul R

    2017-10-01

    Futility disputes in the intensive care unit setting have received significant attention in the literature over the past several years. Although the idea of improving communication in an attempt to resolve these challenging situations has been regularly discussed, the concept and role of trust building as the means by which communication improves and disputes are best navigated is largely absent. We take this opportunity to review the current literature on futility disputes and argue the important role of broken trust in these encounters, highlighting current evidence establishing the necessity and utility of trust in both medical decision-making and effective communication. Finally, we propose a futility dispute navigation model built upon improved communication through trust building.

  2. The role of tourism public-private partnerships in regional development: a conceptual model proposal

    Directory of Open Access Journals (Sweden)

    Mário Franco

    Full Text Available Tourism is characterized as being a sector that stands out as one of the business activities with the greatest potential for worldwide expansion, and as an engine for economic growth. If at the national level, the appeal of tourism is significant, on the local level this sector presents itself as an essential tool in regional development, as a means to avoid regional desertification and stagnation, stimulating the potential of more undeveloped regions. In such a competitive sector as tourism, companies should develop synergies and achieve competitive advantage. In this context, public-private partnerships play an important role in regional development. The aim of this paper is to present a theoretical context that combines different concepts and elements to explain and understand the public-private partnership phenomenon in tourism. A conceptual model of the role of public-private partnerships will be proposed in order to contribute to successful regional development.

  3. Cognitive processes and neural basis of language switching: proposal of a new model.

    Science.gov (United States)

    Moritz-Gasser, Sylvie; Duffau, Hugues

    2009-12-09

    Although studies on bilingualism are abundant, cognitive processes and neural foundations of language switching received less attention. The aim of our study is to provide new insights to this still open question: do dedicated region(s) for language switching exist or is this function underlain by a distributed circuit of interconnected brain areas, part of a more general cognitive system? On the basis of recent behavioral, neuroimaging, and brain stimulation studies, we propose an original 'hodological' model of language switching. This process might be subserved by a large-scale cortico-subcortical network, with an executive system (prefrontal cortex, anterior cingulum, caudate nucleus) controlling a more dedicated language subcircuit, which involves postero-temporal areas, supramarginal and angular gyri, Broca's area, and the superior longitudinal fasciculus.

  4. Computational Approaches to Modeling Artificial Emotion -– An overview of the Proposed Solutions

    Directory of Open Access Journals (Sweden)

    Zdzislaw eKOWALCZUK

    2016-04-01

    Full Text Available Cybernetic approach to modeling artificial emotion through the use of different theories of psychology is considered in this paper, presenting a review of twelve proposed solutions: ActAffAct, FLAME, EMA, ParleE, FearNot!, FAtiMA, WASABI, Cathexis, KARO, MAMID, FCM, and xEmotion. The main motivation for this study is founded on the hypothesis that emotions can play a definite utility role of scheduling variables in the construction of intelligent autonomous systems, agents and mobile robots. In this review we also include an innovative and panoptical, comprehensive system, referred to as the Intelligent System of Decision-making (ISD, which has been employed in practical applications of various autonomous units, and which applies as its part the xEmotion, taking into consideration the personal aspects of emotions, affects (short term emotions and mood (principally, long term emotions.

  5. A proposed simulation optimization model framework for emergency department problems in public hospital

    Science.gov (United States)

    Ibrahim, Ireen Munira; Liong, Choong-Yeun; Bakar, Sakhinah Abu; Ahmad, Norazura; Najmuddin, Ahmad Farid

    2015-12-01

    The Emergency Department (ED) is a very complex system with limited resources to support increase in demand. ED services are considered as good quality if they can meet the patient's expectation. Long waiting times and length of stay is always the main problem faced by the management. The management of ED should give greater emphasis on their capacity of resources in order to increase the quality of services, which conforms to patient satisfaction. This paper is a review of work in progress of a study being conducted in a government hospital in Selangor, Malaysia. This paper proposed a simulation optimization model framework which is used to study ED operations and problems as well as to find an optimal solution to the problems. The integration of simulation and optimization is hoped can assist management in decision making process regarding their resource capacity planning in order to improve current and future ED operations.

  6. An integrated ethical approach to bioethical decision-making: A proposed model for ministers

    Directory of Open Access Journals (Sweden)

    Magdalena C. de Lange

    2012-10-01

    Full Text Available This article outlined a model for guidance in ‘doing’ bioethics in a Reformed context. The proposed model suggested that in order to arrive at responsible ethical decisions, one must refer to both contextual elements and theory. The theoretical grounding for this model was based on the integration of a deontological and virtue ethics approach, arguing that virtue enables persons to know and desire the right moral ends and motivates them to carry out appropriate action toward achieving these ends. An integrative model opens up the possibility whereby bioethics as a systematic tool provides the individual decision-maker with the critical-reflective skills and justification for the ultimate choice that is lacking in the general decision-making processes. This could lead to clearer thinking and increased confidence in the justification of decisions within the Reformed tradition. The proposed hermeneutical perspective on ethical decision-making represents a shift in views about the nature of knowledge and the process of how we come to know. The key to this hermeneutical approach is to acknowledge the dialectic between the universal and the subjectivity of human relations. Working in specific religious communities, one needs to take cognisance of the fact that knowledge is situated in the context of human relationships in which the interpreter participates when articulating the meaning of bioethical experiences. Another aspect that is anticipated lies in the realisation that people struggling with bioethical dilemmas should not be viewed as isolated individuals, but as members of a broader faith community. ‘n Geïntegreerde etiese benadering tot bioetiese besluitneming: Voorgestelde model vir predikante. Hierdie artikel het ‘n model geskets wat moontlike riglyne aantoon vir die  beoefening  van  bioetiek  binne  ‘n  Gereformeerde  konteks.  Die  voorgestelde  model argumenteer dat verwysing na beide kontekstuele elemente en teorie

  7. 3-Dimensional Flow Modeling of a Proposed Hanford Waste Treatment Plant Ion-Exchange Column Design

    International Nuclear Information System (INIS)

    ALEMAN, SEBASTIAN

    2002-01-01

    Historically, it has been assumed that the inlet and outlet low activity waste plenums would be designed such that a nearly uniform velocity profile would be maintained at every axial cross-section (i.e., providing nearly 100 percent use of the resin bed). With this proposed design, we see a LAW outlet distributor that results in significant non-axial velocity gradients in the bottom regions of the bed with the potential to reduce the effectiveness'' of the overall resin bed. The magnitude of this efficiency reduction depends upon how far up-gradient of the LAW outlet these non-axial velocities persist and to what extent a ''dead-zone'' is established beneath the LAW outlet. This can impact loading and elution performance of the ion-exchange facility. Currently, no experimental studies are planned. The primary objective of this work was, through modeling, to assess the fluid dynamic impact on ''effective'' resin volume of the full-scale column based on its normal operation using a recently proposed LAW outlet distributor. The analysis effort was limited to 3-D flow only analyses (i.e., no follow on transport analyses) with 3-D particle tracking to approximate the impact that a nonaxial velocity profile would have on bed ''effectiveness''. Additional analyses were performed to estimate under nominal operating conditions the thermal temperature rise across a loaded resin bed and within its particles. Hydrogen bubble formation is not considered in the heat transfer analysis or in the determination of minimum flowrate. All modeling objectives were met

  8. Automating Construction of Machine Learning Models With Clinical Big Data: Proposal Rationale and Methods.

    Science.gov (United States)

    Luo, Gang; Stone, Bryan L; Johnson, Michael D; Tarczy-Hornoch, Peter; Wilcox, Adam B; Mooney, Sean D; Sheng, Xiaoming; Haug, Peter J; Nkoy, Flory L

    2017-08-29

    To improve health outcomes and cut health care costs, we often need to conduct prediction/classification using large clinical datasets (aka, clinical big data), for example, to identify high-risk patients for preventive interventions. Machine learning has been proposed as a key technology for doing this. Machine learning has won most data science competitions and could support many clinical activities, yet only 15% of hospitals use it for even limited purposes. Despite familiarity with data, health care researchers often lack machine learning expertise to directly use clinical big data, creating a hurdle in realizing value from their data. Health care researchers can work with data scientists with deep machine learning knowledge, but it takes time and effort for both parties to communicate effectively. Facing a shortage in the United States of data scientists and hiring competition from companies with deep pockets, health care systems have difficulty recruiting data scientists. Building and generalizing a machine learning model often requires hundreds to thousands of manual iterations by data scientists to select the following: (1) hyper-parameter values and complex algorithms that greatly affect model accuracy and (2) operators and periods for temporally aggregating clinical attributes (eg, whether a patient's weight kept rising in the past year). This process becomes infeasible with limited budgets. This study's goal is to enable health care researchers to directly use clinical big data, make machine learning feasible with limited budgets and data scientist resources, and realize value from data. This study will allow us to achieve the following: (1) finish developing the new software, Automated Machine Learning (Auto-ML), to automate model selection for machine learning with clinical big data and validate Auto-ML on seven benchmark modeling problems of clinical importance; (2) apply Auto-ML and novel methodology to two new modeling problems crucial for care

  9. [Acute kidney injury after pediatric cardiac surgery: risk factors and outcomes. Proposal for a predictive model].

    Science.gov (United States)

    Cardoso, Bárbara; Laranjo, Sérgio; Gomes, Inês; Freitas, Isabel; Trigo, Conceição; Fragata, Isabel; Fragata, José; Pinto, Fátima

    2016-02-01

    To characterize the epidemiology and risk factors for acute kidney injury (AKI) after pediatric cardiac surgery in our center, to determine its association with poor short-term outcomes, and to develop a logistic regression model that will predict the risk of AKI for the study population. This single-center, retrospective study included consecutive pediatric patients with congenital heart disease who underwent cardiac surgery between January 2010 and December 2012. Exclusion criteria were a history of renal disease, dialysis or renal transplantation. Of the 325 patients included, median age three years (1 day-18 years), AKI occurred in 40 (12.3%) on the first postoperative day. Overall mortality was 13 (4%), nine of whom were in the AKI group. AKI was significantly associated with length of intensive care unit stay, length of mechanical ventilation and in-hospital death (p<0.01). Patients' age and postoperative serum creatinine, blood urea nitrogen and lactate levels were included in the logistic regression model as predictor variables. The model accurately predicted AKI in this population, with a maximum combined sensitivity of 82.1% and specificity of 75.4%. AKI is common and is associated with poor short-term outcomes in this setting. Younger age and higher postoperative serum creatinine, blood urea nitrogen and lactate levels were powerful predictors of renal injury in this population. The proposed model could be a useful tool for risk stratification of these patients. Copyright © 2015 Sociedade Portuguesa de Cardiologia. Published by Elsevier España. All rights reserved.

  10. B220 analysis with the local lymph node assay: proposal for a more flexible prediction model.

    Science.gov (United States)

    Betts, Catherine J; Dearman, Rebecca J; Kimber, Ian; Ryan, Cindy A; Gerberick, G Frank; Lalko, Jon; Api, Anne Marie

    2007-01-01

    The mouse local lymph node assay (LLNA) has been developed and validated for the identification of chemicals that have the potential to induce skin sensitisation. In common with other predictive test methods the accuracy of the LLNA is not absolute and experience has revealed that a few chemicals, including for instance a minority of skin irritants, may elicit false-positive reactions in the assay. To improve further the performance of the LLNA, and to eliminate or reduce false-positives, there has been interest in an adjunct method in which the ability of chemicals to cause increases in the frequency of B220(+) lymphocytes in skin-draining lymph nodes is measured. Previous studies suggest that the use of B220 analyses aligned with the standard LLNA may serve to distinguish further between contact allergens and skin irritants. In the original predictive model, chemicals were regarded as being skin sensitisers if they were able to induce a 1.25-fold or greater increase in the percentage of B220(+) cells within lymph nodes compared with concurrent vehicle controls. Although this first prediction model has proven useful, in the light of more recent experience, and specifically as a consequence of some variability observed in the frequency of B220(+) lymphocytes in nodes taken from vehicle control-treated animals, it is timely now to reconsider and refine the model. As a result a new prediction model is proposed in which reliance on the use of absolute thresholds is reduced, and in which small changes in control values can be better accommodated. (c) 2007 John Wiley & Sons, Ltd.

  11. Nuclear Power Plant Life Management - Challenges and Proposal for a Unified Model Integrating Safety and Economics

    International Nuclear Information System (INIS)

    Contri, Paolo; Elsing, Bernhard

    2011-01-01

    In recent years many electric utilities and nuclear power plants adopted policies for improved coordination of both safety and non-safety programs, called plant life management (PLIM), also in view on plant life extension programs, but mainly for an optimisation of operating costs. The implementation of PLIM programs has followed many different approaches, being intrinsically dependent on the national regulatory framework and technical traditions. In Countries with some experience, the PLIM program proved very convenient, especially when coupled with Maintenance, Surveillance an Inspection (MS and I) optimization: average savings are reported in the range of 20-30% of total (maintenance) costs. A unified European model for PLIM was developed at the JRC-Institute for Energy with the support of a network of stakeholders (SENUF), and validated at some EU nuclear plants. This paper provides a summary of the model features, the result of its validation at some plants and summarises the perceived scientific/technological challenges on which JRC proposes to focus, based upon its competencies and skills, having in mind both the European and world-wide context and its potential evolution. (author)

  12. A proposal of ecologic taxes based on thermo-economic performance of heat engine models

    International Nuclear Information System (INIS)

    Barranco-Jimenez, M. A.; Ramos-Gayosso, I.; Rosales, M. A.; Angulo-Brown, F.

    2009-01-01

    Within the context of Finite-Time Thermodynamics (FTT) a simplified thermal power plant model (the so-called Novikov engine) is analyzed under economical criteria by means of the concepts of profit function and the costs involved in the performance of the power plant. In this study, two different heat transfer laws are used, the so called Newton's law of cooling and the Dulong-Petit's law of cooling. Two FTT optimization criteria for the performance analysis are used: the maximum power regime (MP) and the so-called ecological criterion. This last criterion leads the engine model towards a mode of performance that appreciably diminishes the engine's wasted energy. In this work, it is shown that the energy-unit price produced under maximum power conditions is cheaper than that produced under maximum ecological (ME) conditions. This was accomplished by using a typical definition of profits function stemming from economics. The MP-regime produces considerably more wasted energy toward the environment, thus the MP energy-unit price is subsidized by nature. Due to this fact, an ecological tax is proposed, which could be a certain function of the price difference between the MP and ME modes of power production. (author)

  13. Proposal of a model for sales and operations planning (S&OP maturity evaluation

    Directory of Open Access Journals (Sweden)

    Carolina Belotti Pedroso

    2017-11-01

    Full Text Available Abstract A successful S&OP implementation can bring many benefits to organizations, and after its implementation, the S&OP process can evolve and reach higher levels of maturity. Considering that, only through a measurement system, goals and benefits can be achieved, thus, it is essential to assess S&OP maturity level. Many papers on literature adopt a quantitative perspective on S&OP, but just few of them deal with uncertainty present in S&OP decision-making, such as maturity model assessment process that carries subjectivity and uncertainty. Thus, this study proposes a decision making model based on fuzzy theory to evaluate and to categorize S&OP maturity levels and to suggest strategies to increase S&OP maturity. A pilot application was conducted in two manufacturing organizations that have implemented the S&OP process. The results, according to the performance presented, suggest different actions must be taken in terms of ensuring enablers to S&OP implementation.

  14. A Proposal of Ecologic Taxes Based on Thermo-Economic Performance of Heat Engine Models

    Directory of Open Access Journals (Sweden)

    Fernando Angulo-Brown

    2009-11-01

    Full Text Available Within the context of Finite-Time Thermodynamics (FTT a simplified thermal power plant model (the so-called Novikov engine is analyzed under economical criteria by means of the concepts of profit function and the costs involved in the performance of the power plant. In this study, two different heat transfer laws are used, the so called Newton’s law of cooling and the Dulong-Petit’s law of cooling. Two FTT optimization criteria for the performance analysis are used: the maximum power regime (MP and the so-called ecological criterion. This last criterion leads the engine model towards a mode of performance that appreciably diminishes the engine’s wasted energy. In this work, it is shown that the energy-unit price produced under maximum power conditions is cheaper than that produced under maximum ecological (ME conditions. This was accomplished by using a typical definition of profits function stemming from economics. The MP-regime produces considerably more wasted energy toward the environment, thus the MP energy-unit price is subsidized by nature. Due to this fact, an ecological tax is proposed, which could be a certain function of the price difference between the MP and ME modes of power production.

  15. Competency-Based University Undergraduate Teaching Management: Proposal for a Conceptual Model

    Directory of Open Access Journals (Sweden)

    Rodolfo Schmal

    2005-12-01

    Full Text Available The human resources societies and their organizations can count on are more and more relevant. In that sense, a major challenge faced by universities is to give students the appropriate background to be professionals with the profile the current scenario requires. This article focuses the management of university careers. Historically, many careers have emphasized knowledge, especially abstract knowledge. Today, the trend is to address aspects that reach beyond cognition, and focus the attention in effective competencies that include procedures and attitudes. Such approach allows the opportunity of defining a holistic management of careers, reaching beyond the sheer teaching of disciplines. Concurrently, the availability of information methods and tools will contribute for the definition and implementation of a design process that can work with explicit criteria and transformations. The article proposes a conceptual model to represent the objects, and their attributes and associations that are considered of interest for the management of university teaching under a competency focus. A second stage should implement such model through the construction of an information system that supports the management of corresponding careers.

  16. A proposed model of factors influencing hydrogen fuel cell vehicle acceptance

    Science.gov (United States)

    Imanina, N. H. Noor; Kwe Lu, Tan; Fadhilah, A. R.

    2016-03-01

    Issues such as environmental problem and energy insecurity keep worsening as a result of energy use from household to huge industries including automotive industry. Recently, a new type of zero emission vehicle, hydrogen fuel cell vehicle (HFCV) has received attention. Although there are argues on the feasibility of hydrogen as the future fuel, there is another important issue, which is the acceptance of HFCV. The study of technology acceptance in the early stage is a vital key for a successful introduction and penetration of a technology. This paper proposes a model of factors influencing green vehicle acceptance, specifically HFCV. This model is built base on two technology acceptance theories and other empirical studies of vehicle acceptance. It aims to provide a base for finding the key factors influencing new sustainable energy fuelled vehicle, HFCV acceptance which is achieved by explaining intention to accept HFCV. Intention is influenced by attitude, subjective norm and perceived behavioural control from Theory of Planned Behaviour and personal norm from Norm Activation Theory. In the framework, attitude is influenced by perceptions of benefits and risks, and social trust. Perceived behavioural control is influenced by government interventions. Personal norm is influenced by outcome efficacy and problem awareness.

  17. A proposal of ecologic taxes based on thermo-economic performance of heat engine models

    Energy Technology Data Exchange (ETDEWEB)

    Barranco-Jimenez, M. A. [Departamento de Ciencias Basicas, Escuela Superior de Computo del IPN, Av. Miguel Bernal Esq. Juan de Dios Batiz U.P. Zacatenco CP 07738, D.F. (Mexico); Ramos-Gayosso, I. [Unidad de Administracion de Riesgos, Banco de Mexico, 5 de Mayo, Centro, D.F. (Mexico); Rosales, M. A. [Departamento de Fisica y Matematicas, Universidad de las Americas, Puebla Exhacienda Sta. Catarina Martir, Cholula 72820, Puebla (Mexico); Angulo-Brown, F. [Departamento de Fisica, Escuela Superior de Fisica y Matematicas del IPN, Edif. 9 U.P. Zacatenco CP 07738, D.F. (Mexico)

    2009-07-01

    Within the context of Finite-Time Thermodynamics (FTT) a simplified thermal power plant model (the so-called Novikov engine) is analyzed under economical criteria by means of the concepts of profit function and the costs involved in the performance of the power plant. In this study, two different heat transfer laws are used, the so called Newton's law of cooling and the Dulong-Petit's law of cooling. Two FTT optimization criteria for the performance analysis are used: the maximum power regime (MP) and the so-called ecological criterion. This last criterion leads the engine model towards a mode of performance that appreciably diminishes the engine's wasted energy. In this work, it is shown that the energy-unit price produced under maximum power conditions is cheaper than that produced under maximum ecological (ME) conditions. This was accomplished by using a typical definition of profits function stemming from economics. The MP-regime produces considerably more wasted energy toward the environment, thus the MP energy-unit price is subsidized by nature. Due to this fact, an ecological tax is proposed, which could be a certain function of the price difference between the MP and ME modes of power production. (author)

  18. Proposal for a New Model for Highway Records in the Republic of Croatia

    Directory of Open Access Journals (Sweden)

    Rinaldo Paar

    2012-05-01

    Full Text Available Highways are public roads, whose function is to integrate Croatia in the European transport system, link the regions of Croatia and facilitate transit traffic. They are public property for general use, owned by the Republic of Croatia, and they cannot be the subject of acquisition or other proprietary rights of any kind. Today, there are two types of highway record-keeping. The first is conducted by leading companies authorised to manage highways in order to develop a highway database, or create a highway register. The second is conducted by land-management systems; the Cadastre and Land Registry. They are the official public registers for keeping records of land plots, buildings and other structures, and their ownership. Procedures that need to be implemented in the second type of record-keeping often get "stuck" in practice. Based on the problems identified in this model and an analysis of the state of record-keeping, a proposal for a new model for highway records in the Cadastre and Land Registry is given. Keywords: highways; building plot; expropriation; record; Cadastre; Land Registry

  19. Proposal of a stationary model of dispersion diagnoses of pollutants chemically non-reactivate, applied for mobile sources in Bogota

    International Nuclear Information System (INIS)

    Ruiz Murcia, Jose Franklln; Pabon Caicedo, Jose Daniel

    2002-01-01

    The following document presents a semi empirical model to calculate concentrations of monoxide of carbon in surface by mobile sources. This model considers three basic components: meteorology, emissions and atmospheric chemistry. Scientifically, the propose model is sustained en the fact that the quality of the air depends of the weather's conditions and the numbers of source that is emitting

  20. Circulation Modeling for Proposed Port Facility at Ponce and Guayanilla, Puerto Rico

    National Research Council Canada - National Science Library

    Scheffner, Norman

    2002-01-01

    ... of Ponce and Guayanilla, Puerto Rico. Impacts of the proposed construction were determined by conducting numerical simulations of tidal and storm surge circulation at the project sites using with and without the proposed port facilities...

  1. Incorporating the user perspective into a proposed model for assessing success of SHS implementations

    Directory of Open Access Journals (Sweden)

    Hans Holtorf

    2015-10-01

    Full Text Available Modern energy can contribute to development in multiple ways while approximately 20% of world's populations do not yet have access to electricity. Solar Home Systems (SHSs consists of a PV module, a charge controller and a battery supply in the range of 100 Wh/d in Sunbelt countries. The question addressed in this paper is how SHS users approach success of their systems and how these user's views can be integrated in to an existing model of success. Information was obtained on the user's approach to their SHSs by participatory observation, interviews with users and by self-observation undertaken by the lead author while residing under SHS electricity supply conditions. It was found that success of SHSs from the users' point of view is related to the ability of these systems to reduce the burdens of supplying energy services to homesteads. SHSs can alleviate some energy supply burdens, and they can improve living conditions by enabling communication on multiple levels and by addressing convenience and safety concerns. However, SHSs do not contribute to the energy services which are indispensable for survival, nor to the thermal energy services required and desired in dwellings of Sunbelt countries. The elements of three of the four components of our previously proposed model of success have been verified and found to be appropriate, namely the user's self-set goals, their importance and SHSs' success factors. The locally appropriate, and scientifically satisfactory, measurement of the level of achievement of self-set goals, the fourth component of our model of success, remains an interesting area for future research.

  2. Proposed best modeling practices for assessing the effects of ecosystem restoration on fish

    Science.gov (United States)

    Rose, Kenneth A; Sable, Shaye; DeAngelis, Donald L.; Yurek, Simeon; Trexler, Joel C.; Graf, William L.; Reed, Denise J.

    2015-01-01

    Large-scale aquatic ecosystem restoration is increasing and is often controversial because of the economic costs involved, with the focus of the controversies gravitating to the modeling of fish responses. We present a scheme for best practices in selecting, implementing, interpreting, and reporting of fish modeling designed to assess the effects of restoration actions on fish populations and aquatic food webs. Previous best practice schemes that tended to be more general are summarized, and they form the foundation for our scheme that is specifically tailored for fish and restoration. We then present a 31-step scheme, with supporting text and narrative for each step, which goes from understanding how the results will be used through post-auditing to ensure the approach is used effectively in subsequent applications. We also describe 13 concepts that need to be considered in parallel to these best practice steps. Examples of these concepts include: life cycles and strategies; variability and uncertainty; nonequilibrium theory; biological, temporal, and spatial scaling; explicit versus implicit representation of processes; and model validation. These concepts are often not considered or not explicitly stated and casual treatment of them leads to mis-communication and mis-understandings, which in turn, often underlie the resulting controversies. We illustrate a subset of these steps, and their associated concepts, using the three case studies of Glen Canyon Dam on the Colorado River, the wetlands of coastal Louisiana, and the Everglades. Use of our proposed scheme will require investment of additional time and effort (and dollars) to be done effectively. We argue that such an investment is well worth it and will more than pay back in the long run in effective and efficient restoration actions and likely avoided controversies and legal proceedings.

  3. A System Thinking Model Proposal for Enterprise Application Integration (EAI Evaluation Completeness

    Directory of Open Access Journals (Sweden)

    Irene Nakiyimba

    2014-01-01

    Full Text Available Research has identified a number of approaches for evaluating Enterprise Application Integration (EAI. The majority of these approaches focus primarily on the technical functional and non-functional capabil¬ities of an EAI solution. Although, where the technical dimensions have received considerable attention from researchers, other dimensions needed for EAI evaluation, such as stakeholder feedback, have not re¬ceived explicit consideration. As a result, attaining a consummate EAI solution is still a major challenge for many enterprises. The current EAI evaluation models simply provide piecemeal insights towards the evaluation criteria variables from limited stakeholder perceptions and do not help to understand EAI evaluation as a dynamic, feedback, time based and non-linear problem. Different stakeholders view the outcome of an EAI project from different perspectives and therefore will more likely than not arrive at different conclusions. To achieve a consensus among stakeholder perceptions, we represent EAI evaluation as a feedback analysis problem from multi-stakeholder perceptions for proper alignment with business goals, vision and mission. This paper proposes the application of System Dynamics (SD model towards guiding policy analysis for evaluating criteria factors from multi-stakeholders perceptions for EAI adoption; this will provide for holistic evaluation where emphasis is the importance of evaluation as whole (not piece meal perceptions and the interdependence of evaluation criteria factors from the diverse stakeholder perceptions is analyzed. In this paper we present a case-study performed at a large portion of the East African banking system. A total of 800 responses to questionnaires are analyzed to formulate a systems thinking model, which in turn allows us to analyze feedback loops between different stakeholders with distinct evaluation criteria. Findings result in a structured and holistic systems thinking model which

  4. Nutrition factors predict earlier acquisition of motor and language milestones among young children in Haiti.

    Science.gov (United States)

    Iannotti, Lora; Jean Louis Dulience, Sherlie; Wolff, Patricia; Cox, Katherine; Lesorogol, Carolyn; Kohl, Patricia

    2016-09-01

    To examine the nutrition-related factors associated with motor and language development among young children living in a poor urban area of Haiti. Children aged 6-11 months (n = 583) were enrolled and followed monthly for one year. World Health Organization motor developmental milestones and vowel and consonant counts were assessed. Longitudinal regression models were applied to assess the association of anthropometric, dietary intake, infectious disease morbidity and socio-economic and demographic factors on developmental outcomes. At baseline, 9.4% were stunted or length-for-age Z score < -2, and 30.2% were mild-to-moderately stunted or length-for-age Z score < -1. Stunting status was significantly associated with motor and phonetic language acquisition at each time point during infancy. Several nutrition factors significantly predicted earlier achievement of motor and language development outcomes in longitudinal models: child anthropometry; breastfeeding and complementary feeding frequencies; dietary diversity; egg and oil intake; and reduced infectious disease morbidities. Increases in the length-for-age Z score significantly predicted all motor and language outcomes and yielded the best fit models compared to other anthropometric indicators (p < 0.001). Child development interventions may be enhanced by incorporating nutrition strategies such as improved diet quality, breastfeeding promotion and diarrhoeal disease mitigation. ©2016 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  5. In-utero cigarette smoke exposure and the risk of earlier menopause

    NARCIS (Netherlands)

    Honorato, Talita C; Haadsma, Maaike L; Land, Jolande A; Boezen, Marike H; Hoek, Annemieke; Groen, Henk

    2018-01-01

    OBJECTIVE: Cigarette smoking is a risk factor for earlier menopause. Animal studies show that in-utero smoke exposure is toxic to developing ovaries. Our aim was to evaluate whether in-utero smoke exposed women reach menopause earlier compared with nonexposed women. METHODS: This is a cohort study

  6. Proposed Model for Translational Research at a Teaching-Intensive College of Pharmacy.

    Science.gov (United States)

    Ulrich, Erin; Grady, Sarah; Vonderhaar, Jacqueline; Ruplin, Andrew

    2017-08-08

    Many American colleges of pharmacy are small, private, teaching institutions. Faculty are required to maintain a research agenda, although the publication quota is less compared with their publicly funded college of pharmacy peers. Faculty at these smaller schools conduct research with very little internal or external funding. This tends to lead to smaller, less impactful research findings. Translational research is becoming popular for research faculty as it bridges theory to practice. The Knowledge-to-Action (KTA) framework presents the steps to conduct translational research. To apply and determine if the KTA framework would be able to produce practice-impactful research at an institution that does not depend on grant funding as part of faculty research agendas. An interdisciplinary team was formed with providers at the clinical faculty's practice site. As the team moved through the KTA steps, authors documented the roles of each team member. It was clear that many different types of teams were formed throughout the KTA process. These teams were then categorized according to the Interdisciplinary Teamwork System. The final result is a proposed model of types of teams and required member roles that are necessary within each KTA step for faculty to conduct practice-impactful research at a small, private, teaching institution without substantial grant funding awards. Applying the KTA framework, two impactful original research manuscripts were developed over two academic years. Furthermore, the practitioners at the clinical faculty member's site were very pleased with the ease of conducting research, as they were never required to take a lead role. In addition, both faculty members alternated lead and support role allowing for a decreased burden of workload while producing theory-driven research. The KTA framework can create a model for translational research and may be particularly beneficial to small teaching institutions to conduct impactful research. Copyright

  7. Parent and family impact of autism spectrum disorders: a review and proposed model for intervention evaluation.

    Science.gov (United States)

    Karst, Jeffrey S; Van Hecke, Amy Vaughan

    2012-09-01

    Raising a child with an autism spectrum disorder (ASD) can be an overwhelming experience for parents and families. The pervasive and severe deficits often present in children with ASD are associated with a plethora of difficulties in caregivers, including decreased parenting efficacy, increased parenting stress, and an increase in mental and physical health problems compared with parents of both typically developing children and children with other developmental disorders. In addition to significant financial strain and time pressures, high rates of divorce and lower overall family well-being highlight the burden that having a child with an ASD can place on families. These parent and family effects reciprocally and negatively impact the diagnosed child and can even serve to diminish the positive effects of intervention. However, most interventions for ASD are evaluated only in terms of child outcomes, ignoring parent and family factors that may have an influence on both the immediate and long-term effects of therapy. It cannot be assumed that even significant improvements in the diagnosed child will ameliorate the parent and family distress already present, especially as the time and expense of intervention can add further family disruption. Thus, a new model of intervention evaluation is proposed, which incorporates these factors and better captures the transactional nature of these relationships.

  8. [Proposed difficult airway teaching methodology. Presentation of an interactive fresh frozen cadaver model].

    Science.gov (United States)

    Catalá Bauset, J C; de Andres Ibañez, J A; Valverde Navarro, A; Martinez Soriano, F

    2014-04-01

    The aim of this paper is to present a methodology based on the use of fresh-frozen cadavers for training in the management of the airway, and to evaluate the degree of satisfaction among learning physicians. About 6 fresh-frozen cadavers and 14 workstations were prepared where participants were trained in the different skills needed for airway management. The details of preparation of the cadavers are described. The level of satisfaction of the participant was determined using a Likert rating scale of 5 points, at each of the 14 stations, as well as the overall assessment and clinical usefulness of the course. The mean overall evaluation of the course and its usefulness was 4.75 and 4.9, out of 5, respectively. All parts of the course were rated above 4 out of 5. The high level of satisfaction of the course remained homogeneous in the 2 editions analysed. The overall satisfaction of the course was not finally and uniquely determined by any of its particular parts. The fresh cadaver model for training physicians in techniques of airway management is a proposal satisfactory to the participant, and with a realism that approaches the live patient. Copyright © 2013 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España. All rights reserved.

  9. Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution

    Science.gov (United States)

    Niida, Atsushi; Shimamura, Teppei; Hirata, Hidenari; Sugimachi, Keishi; Sawada, Genta; Iwaya, Takeshi; Kurashige, Junji; Shinden, Yoshiaki; Iguchi, Tomohiro; Eguchi, Hidetoshi; Chiba, Kenichi; Shiraishi, Yuichi; Nagae, Genta; Yoshida, Kenichi; Nagata, Yasunobu; Haeno, Hiroshi; Yamamoto, Hirofumi; Ishii, Hideshi; Doki, Yuichiro; Iinuma, Hisae; Sasaki, Shin; Nagayama, Satoshi; Yamada, Kazutaka; Yachida, Shinichi; Kato, Mamoru; Shibata, Tatsuhiro; Oki, Eiji; Saeki, Hiroshi; Shirabe, Ken; Oda, Yoshinao; Maehara, Yoshihiko; Komune, Shizuo; Mori, Masaki; Suzuki, Yutaka; Yamamoto, Ken; Aburatani, Hiroyuki; Ogawa, Seishi; Miyano, Satoru; Mimori, Koshi

    2016-01-01

    Understanding intratumor heterogeneity is clinically important because it could cause therapeutic failure by fostering evolutionary adaptation. To this end, we profiled the genome and epigenome in multiple regions within each of nine colorectal tumors. Extensive intertumor heterogeneity is observed, from which we inferred the evolutionary history of the tumors. First, clonally shared alterations appeared, in which C>T transitions at CpG site and CpG island hypermethylation were relatively enriched. Correlation between mutation counts and patients’ ages suggests that the early-acquired alterations resulted from aging. In the late phase, a parental clone was branched into numerous subclones. Known driver alterations were observed frequently in the early-acquired alterations, but rarely in the late-acquired alterations. Consistently, our computational simulation of the branching evolution suggests that extensive intratumor heterogeneity could be generated by neutral evolution. Collectively, we propose a new model of colorectal cancer evolution, which is useful for understanding and confronting this heterogeneous disease. PMID:26890883

  10. The Brazilian Unified National Health System: Proposal of a Cost-effectiveness Evaluation Model

    Directory of Open Access Journals (Sweden)

    Lilian Ribeiro de Oliveira

    2016-04-01

    Full Text Available The Brazilian Unified National Health System (Sistema Único de Saúde [SUS] is in a prominent position compared to the existing social policies. One of the new tools used by SUS is known as Performance Index of the Unified Health System (Índice de Desempenho do Sistema Único de Saúde [IDSUS], which is intended to measure the performance of each municipality. Therefore, the aim of this study was to propose a model of cost-effectiveness to compare IDSUS performance against total revenues achieved in Homogeneous Group 2, consisting of 94 municipalities and analysed using data from IDSUS and the System Information of the Public Budget for Health Care (Sistema de Informação do Orçamento Público em Saúde [SIOPS] for the year 2011. After structuring this data, we carried out descriptive statistical and cluster analysis in order to group similar municipalities in accordance with established variables: IDSUS performance, population and total revenue in health per capita. Even with the division of municipalities into homogeneous groups and after using variables such as population and revenue to regroup them, the results showed there are municipalities with heterogeneous characteristics. Another finding is in the use and intersection of two distinct databases (IDSUS and SIOPS, which allowed for visualizing the impact of health care revenue on the municipalities performance.

  11. A qualitative model for strategic analysis of organizations. Application and alternative proposal on a study case

    Directory of Open Access Journals (Sweden)

    Santiago Ferro Moreno

    2015-12-01

    Full Text Available The strategic analysis of organizations is based on the internal and external environments, in order to identify positive and negative variables and factors. The interrelation and timing of these strategic forces are essential to create alternative solutions that tend to achieve the organizational objectives.The normative prospective has theorical and methodological foundations to create a desired future and from it, be able to identify impelling and restraining forces that have influence on the particular problematic situation (go from the current situation to a better one in a certain time.The aim of this article is to analyze on a strategic way a real case with a normative-prospective model that considers the temporal dynamics of the factors impact and variables in time allowing to suggest alternative solutions.Semi-structured interviews were performed with all the employees of this case and structured observations and workshops with the commercial and general management.In consequence, with the results, the desired, current and improved situations were built. Additionally, forces were identified classified and appreciated and lastly solutions were suggested. With the proposed prospective method, alternative solutions could be constructed in order to settle temporary organizational objectives. No constraints were found to use the current method in other cases.Keywords: Strategic forces, Normative prospective, Problematic situations, Strategies

  12. Evaluation of six NEHRP B/C crustal amplification models proposed for use in western North America

    Science.gov (United States)

    Boore, David; Campbell, Kenneth W.

    2016-01-01

    We evaluate six crustal amplification models based on National Earthquake Hazards Reduction Program (NEHRP) B/C crustal profiles proposed for use in western North America (WNA) and often used in other active crustal regions where crustal properties are unknown. One of the models is based on an interpolation of generic rock velocity profiles previously proposed for WNA and central and eastern North America (CENA), in conjunction with material densities based on an updated velocity–density relationship. A second model is based on the velocity profile used to develop amplification factors for the Next Generation Attenuation (NGA)‐West2 project. A third model is based on a near‐surface velocity profile developed from the NGA‐West2 site database. A fourth model is based on velocity and density profiles originally proposed for use in CENA but recently used to represent crustal properties in California. We propose two alternatives to this latter model that more closely represent WNA crustal properties. We adopt a value of site attenuation (κ0) for each model that is either recommended by the author of the model or proposed by us. Stochastic simulation is used to evaluate the Fourier amplification factors and their impact on response spectra associated with each model. Based on this evaluation, we conclude that among the available models evaluated in this study the NEHRP B/C amplification model of Boore (2016) best represents median crustal amplification in WNA, although the amplification models based on the crustal profiles of Kamai et al. (2013, 2016, unpublished manuscript, see Data and Resources) and Yenier and Atkinson (2015), the latter adjusted to WNA crustal properties, can be used to represent epistemic uncertainty.

  13. A new approach for modeling the peak utility impacts from a proposed CUAC standard

    Energy Technology Data Exchange (ETDEWEB)

    LaCommare, Kristina Hamachi; Gumerman, Etan; Marnay, Chris; Chan, Peter; Coughlin, Katie

    2004-08-01

    This report describes a new Berkeley Lab approach for modeling the likely peak electricity load reductions from proposed energy efficiency programs in the National Energy Modeling System (NEMS). This method is presented in the context of the commercial unitary air conditioning (CUAC) energy efficiency standards. A previous report investigating the residential central air conditioning (RCAC) load shapes in NEMS revealed that the peak reduction results were lower than expected. This effect was believed to be due in part to the presence of the squelch, a program algorithm designed to ensure changes in the system load over time are consistent with the input historic trend. The squelch applies a system load-scaling factor that scales any differences between the end-use bottom-up and system loads to maintain consistency with historic trends. To obtain more accurate peak reduction estimates, a new approach for modeling the impact of peaky end uses in NEMS-BT has been developed. The new approach decrements the system load directly, reducing the impact of the squelch on the final results. This report also discusses a number of additional factors, in particular non-coincidence between end-use loads and system loads as represented within NEMS, and their impacts on the peak reductions calculated by NEMS. Using Berkeley Lab's new double-decrement approach reduces the conservation load factor (CLF) on an input load decrement from 25% down to 19% for a SEER 13 CUAC trial standard level, as seen in NEMS-BT output. About 4 GW more in peak capacity reduction results from this new approach as compared to Berkeley Lab's traditional end-use decrement approach, which relied solely on lowering end use energy consumption. The new method has been fully implemented and tested in the Annual Energy Outlook 2003 (AEO2003) version of NEMS and will routinely be applied to future versions. This capability is now available for use in future end-use efficiency or other policy analysis

  14. Proposal of the mathematical model of the aquifer for interpretation of measurements of natural isotopes in the water

    International Nuclear Information System (INIS)

    Nawalany, M.

    1975-01-01

    Mathematical models applied in isotope hydrology are presented in the paper. The most commonly used deterministic models are discussed in the first part of the paper including the piston flow and good mixing models. The model of nonideal mixing is introduced by the author into the hydrological considerations. This model is a generalization of the good mixing model and allows for different processes of mixing of natural isotopes in waters of hydrological systems. The most important stochastic model i.e. the dispersive model is discussed too. The ''three-velocities'' model is proposed the first time by the author. The ''three-velocities'' model differs from the other ones in following properties: it includes finite flow velocity of the tracer particles, it takes into account the presence of stagnant water, it satisfied the law of fluid continuity, it is convergent to the piston-flow model in limit. However the model proposed describes dispersion phenomenon and satisfied the tracer conservation law (i.e. standarization) - the two properties characteristic of all the models. The author's strong belief is that the user (hydrologist) having at his disposal given below review of the models will be able to choose the most adequate model in given hydrological conditions. (author)

  15. Advocating for School Psychologists in Response to the APA's Proposed "Model Act for State Licensure of Psychologists"

    Science.gov (United States)

    Skalski, Anastasia Kalamaros

    2009-01-01

    On March 6, 2009, the APA Model Licensure Act Task Force released its second draft of the policy document known as the proposed "Model Act for State Licensure of Psychologists". This policy document serves as guidance to state legislatures for how they should set up their psychology licensing laws. The general expectations promoted in the model…

  16. Leveraging ISI Multi-Model Prediction for Navy Operations: Proposal to the Office of Naval Research

    Science.gov (United States)

    2013-09-30

    Operations: Proposal to the Office of Naval Research” PI: Benjamin Kirtman University of Miami – RSMAS Meteorology and Physical Oceanography...Prediction for Navy Operations: Proposal to the Office of Naval Research 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d

  17. Modeling commuter preferences for the proposed bus rapid transit in Dar-es-Salaam

    NARCIS (Netherlands)

    Nkurunziza, A.; Zuidgeest, M.H.P.; Brussel, M.J.G.; van Maarseveen, M.F.A.M.

    2012-01-01

    The paper analyzes individual commuter preferences towards the proposed bus rapid transit (BRT) system in Dar-es-Salaam, Tanzania. The objective of the survey was to identify how commuters perceive and value the proposed BRT service quality attributes. A stated preference survey of potential users

  18. A proposal on alternative sampling-based modeling method of spherical particles in stochastic media for Monte Carlo simulation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Song Hyun; Lee, Jae Yong; KIm, Do Hyun; Kim, Jong Kyung [Dept. of Nuclear Engineering, Hanyang University, Seoul (Korea, Republic of); Noh, Jae Man [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-08-15

    Chord length sampling method in Monte Carlo simulations is a method used to model spherical particles with random sampling technique in a stochastic media. It has received attention due to the high calculation efficiency as well as user convenience; however, a technical issue regarding boundary effect has been noted. In this study, after analyzing the distribution characteristics of spherical particles using an explicit method, an alternative chord length sampling method is proposed. In addition, for modeling in finite media, a correction method of the boundary effect is proposed. Using the proposed method, sample probability distributions and relative errors were estimated and compared with those calculated by the explicit method. The results show that the reconstruction ability and modeling accuracy of the particle probability distribution with the proposed method were considerably high. Also, from the local packing fraction results, the proposed method can successfully solve the boundary effect problem. It is expected that the proposed method can contribute to the increasing of the modeling accuracy in stochastic media.

  19. A proposal on alternative sampling-based modeling method of spherical particles in stochastic media for Monte Carlo simulation

    International Nuclear Information System (INIS)

    Kim, Song Hyun; Lee, Jae Yong; KIm, Do Hyun; Kim, Jong Kyung; Noh, Jae Man

    2015-01-01

    Chord length sampling method in Monte Carlo simulations is a method used to model spherical particles with random sampling technique in a stochastic media. It has received attention due to the high calculation efficiency as well as user convenience; however, a technical issue regarding boundary effect has been noted. In this study, after analyzing the distribution characteristics of spherical particles using an explicit method, an alternative chord length sampling method is proposed. In addition, for modeling in finite media, a correction method of the boundary effect is proposed. Using the proposed method, sample probability distributions and relative errors were estimated and compared with those calculated by the explicit method. The results show that the reconstruction ability and modeling accuracy of the particle probability distribution with the proposed method were considerably high. Also, from the local packing fraction results, the proposed method can successfully solve the boundary effect problem. It is expected that the proposed method can contribute to the increasing of the modeling accuracy in stochastic media

  20. Cigarette smoking and depression comorbidity: systematic review and proposed theoretical model.

    Science.gov (United States)

    Mathew, Amanda R; Hogarth, Lee; Leventhal, Adam M; Cook, Jessica W; Hitsman, Brian

    2017-03-01

    Despite decades of research on co-occurring smoking and depression, cessation rates remain consistently lower for depressed smokers than for smokers in the general population, highlighting the need for theory-driven models of smoking and depression. This paper provides a systematic review with a particular focus upon psychological states that disproportionately motivate smoking in depression, and frame an incentive learning theory account of smoking-depression co-occurrence. We searched PubMed, Scopus, PsychINFO and CINAHL to December 2014, which yielded 852 papers. Using pre-established eligibility criteria, we identified papers focused on clinical issues and motivational mechanisms underlying smoking in established, adult smokers (i.e. maintenance, quit attempts and cessation/relapse) with elevated symptoms of depression. Two reviewers determined independently whether papers met review criteria. We included 297 papers in qualitative synthesis. Our review identified three primary mechanisms that underlie persistent smoking among depressed smokers: low positive affect, high negative affect and cognitive impairment. We propose a novel application of incentive learning theory which posits that depressed smokers experience greater increases in the expected value of smoking in the face of these three motivational states, which promotes goal-directed choice of smoking behavior over alternative actions. The incentive learning theory accounts for current evidence on how depression primes smoking behavior and provides a unique framework for conceptualizing psychological mechanisms of smoking maintenance among depressed smokers. Treatment should focus upon correcting adverse internal states and beliefs about the high value of smoking in those states to improve cessation outcomes for depressed smokers. © 2016 Society for the Study of Addiction.

  1. Analysis of Participation Banks in Turkey in Terms of Agency Theory and a Model Proposal

    Directory of Open Access Journals (Sweden)

    Musa GÜN

    2016-04-01

    Full Text Available The agency theory considers the problems between agents and principal and aims to reduce the agency costs arising from these problems.  The theory could be applied in various fields and in many different areas where principal-agent relations occur. Participation banks in Turkey operating banking services based on Islamic principals are able to implement many different banking facilities. They could be regarded as supplementary alternatives to the conventional banks and thus, participation banks provide depth and financial product range in the banking sector.  There are many different studies on several fields and subjects about participation banks and Islamic banks both in national and in international literature.  However, the studies discussing the fatwa structure in the context of agency theory are very rare especially for the participation banks in Turkey. Thus, this study examines the Sariah advisory board mechanism of the participation banks in particular within the scope of agency problems and it focuses on a model proposal that could resolve agency cost. In Turkey, there is not a nationwide nor a Shariah agency or institution which control, regulate and/or supervise the services, operations, and activities of the participation banks, in accordance with Islamic concepts. In this context, the establishment of an independent Islamic Supervisory Council will help to reduce agency costs. Furthermore, sustainability and stability of Islamic financial markets will increase together with issuing appropriate financial products in compliance with Shariah principles and thus the Council will help Istanbul to achieve the goal of being the financial center.

  2. A PROPOSAL FOR A SUSTAINABLE MODEL BASED UPON UNDERWATER TOURISM RESEARCH IN AYVALIK

    Directory of Open Access Journals (Sweden)

    A. GÖKDENİZ

    2013-03-01

    Full Text Available Underwater sports are the activities being done with the aims of witnessing the beauties, hunting, taking photos, the ecology and the archaeology of underwater analysing or finding out the human being’s boundaries by improving the physical and psychological skills of men. The initial aim of this project is to increase the underwater flora and the fauna heritage of Ayvalık and to bring them in tourism. Ayvalık is on the west coast of Turkey. It is getting more and more famous with its underwater richness. Also, to form a new underwater sports centre in order to contribute to the improvement of the region. By providing visual attractiveness, the tourists related to underwater sports will pay attention to Ayvalık and underwater tourism will contribute much to the economy of the region. The aim of this project is to improve the underwater sports which is now a hobby than a sport. In Ayvalık Underwater World study, we dealt with 247 divers and 4 underwater sports club. In this study, we analysed the expectation, satisfaction, demographic and economic level of 247 divers about the services in the region. Interview technique has been used in the study on the 4 underwater sports clubs which are hosting divers. As a conclusion, a report has been prepared in which detailed information and proposals are presented by developing a sustainable marketing model concerned with the underwater sports for those who want to possess information, shareholders of the sector and make analyse about tourism.

  3. A proposed agglomerate model for oxygen reduction in the catalyst layer of proton exchange membrane fuel cells

    International Nuclear Information System (INIS)

    Zhang, Xiaoxian; Gao, Yuan; Ostadi, Hossein; Jiang, Kyle; Chen, Rui

    2014-01-01

    Highlights: • We developed a new agglomerate model to describe oxygen reduction reaction. • We showed how to calculate the model parameters from catalyst layer structure. • We verified the agglomerate model. - Abstract: Oxygen diffusion and reduction in the catalyst layer of PEM fuel cell is an important process in fuel cell modelling, but models able to link the reduction rate to catalyst-layer structure are lack; this paper makes such an effort. We first link the average reduction rate over the agglomerate within a catalyst layer to a probability that an oxygen molecule, which is initially on the agglomerate surface, will enter and remain in the agglomerate at any time in the absence of any electrochemical reaction. We then propose a method to directly calculate distribution function of this probability and apply it to two catalyst layers with contrasting structures. A formula is proposed to describe these calculated distribution functions, from which the agglomerate model is derived. The model has two parameters and both can be independently calculated from catalyst layer structures. We verify the model by first showing that it is an improvement and able to reproduce what the spherical model describes, and then testing it against the average oxygen reductions directly calculated from pore-scale simulations of oxygen diffusion and reaction in the two catalyst layers. The proposed model is simple, but significant as it links the average oxygen reduction to catalyst layer structures, and its two parameters can be directly calculated rather than by calibration

  4. A proposed cell model for multiple-occurrence regional landslide events: Implications for landslide susceptibility mapping

    Science.gov (United States)

    Crozier, M. J.

    2017-10-01

    Multiple-occurrence regional landslide events (MORLEs) consist of hundreds to thousands of shallow landslides occurring more or less simultaneously within defined areas, ranging from tens to thousands of square kilometres. While MORLEs can be triggered by rainstorms and earthquakes, this paper is confined to those landslide events triggered by rainstorms. Globally, MORLEs occur in a range of geological settings in areas of moderate to steep slopes subject to intense rainstorms. Individual landslides in rainstorm-triggered events are dominantly small, shallow debris and earth flows, and debris and earth slides involving regolith or weathered bedrock. The model used to characterise these events assumes that energy distribution within the event area is represented on the land surface by a cell structure; with maximum energy expenditure within an identifiable core and rapid dissipation concentrically away from the centre. The version of the model presented here has been developed for rainfall-triggered landslide events. It proposes that rainfall intensity can be used to determine different critical landslide response zones within the cell (referred to as core, middle, and periphery zones). These zones are most readily distinguished by two conditions: the proportion of the slope that fails and the particular type of the slope stability factor that assumes dominance in determining specific sites of landslide occurrence. The latter condition means that the power of any slope stability factor to distinguish between stable and unstable sites varies throughout the affected area in accordance with the landslide response zones within the cell; certain factors critical for determining the location of landslide sites in one part of the event area have little influence in other parts of the event area. The implication is that landslide susceptibility maps (and subsequently derived mitigation measures) based on conventional slope stability factors may have only limited validity

  5. A Proposal of New Spherical Particle Modeling Method Based on Stochastic Sampling of Particle Locations in Monte Carlo Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Song Hyun; Kim, Do Hyun; Kim, Jong Kyung [Hanyang Univ., Seoul (Korea, Republic of); Noh, Jea Man [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    To the high computational efficiency and user convenience, the implicit method had received attention; however, it is noted that the implicit method in the previous studies has low accuracy at high packing fraction. In this study, a new implicit method, which can be used at any packing fraction with high accuracy, is proposed. In this study, the implicit modeling method in the spherical particle distributed medium for using the MC simulation is proposed. A new concept in the spherical particle sampling was developed to solve the problems in the previous implicit methods. The sampling method was verified by simulating the sampling method in the infinite and finite medium. The results show that the particle implicit modeling with the proposed method was accurately performed in all packing fraction boundaries. It is expected that the proposed method can be efficiently utilized for the spherical particle distributed mediums, which are the fusion reactor blanket, VHTR reactors, and shielding analysis.

  6. Does menopause start earlier in smokers? Evidence from the Pro-Saude Study

    Directory of Open Access Journals (Sweden)

    Paula de Holanda Mendes

    2013-12-01

    Full Text Available OBJECTIVES: cigarette smoking has been the modifiable risk factor most consistently associated with earlier menopause. This preliminary study based on cross-sectional data aimed to analyze the association between smoking status and age of onset of menopause in a Brazilian population. METHODS: a cross-sectional study was carried out with 1,222 female employees of Rio de Janeiro university campuses aged over 35 years who were at risk of natural menopause. A Cox proportional hazards model was used to investigate the association between smoking status and age at the onset of menopause, adjusting for education, parity and alcohol consumption. RESULTS: current smokers showed a 56% increase in the risk of menopause, being 1.8 years younger at menopause onset compared with women who had never smoked. However, no differences were observed between former smokers and women who had never smoked. The adjusted median age at menopause was 49.5 years for current smokers and 51.3 years for women who had never smoked (p<0.05. CONCLUSIONS: the results suggest a deleterious but potentially reversible effect of smoking on the age of onset of menopause, which should receive greater attention in tobacco control efforts. Longitudinal analyses of this association will be carried out in the future in a follow-up study of this population.

  7. Polymorphism in ficolin-1 ( FCN1 ) gene is associated with an earlier ...

    Indian Academy of Sciences (India)

    -1 (FCN1) gene is associated with an earlier onset of type 1 diabetes mellitus in children and adolescents from northeast Brazil. ZILMA PEREIRA DOS ANJOSA MANUELLA MARIA SILVA SANTOS NATASSIA JAVORSKI RODRIGUES ...

  8. Proposal for Classifying the Severity of Speech Disorder Using a Fuzzy Model in Accordance with the Implicational Model of Feature Complexity

    Science.gov (United States)

    Brancalioni, Ana Rita; Magnago, Karine Faverzani; Keske-Soares, Marcia

    2012-01-01

    The objective of this study is to create a new proposal for classifying the severity of speech disorders using a fuzzy model in accordance with a linguistic model that represents the speech acquisition of Brazilian Portuguese. The fuzzy linguistic model was run in the MATLAB software fuzzy toolbox from a set of fuzzy rules, and it encompassed…

  9. Emerging identities: A proposed model for an interactive science curriculum for First Nations students

    Science.gov (United States)

    Sable, Trudy

    Mi'kmaw students face a complexity of personal, cultural, and social conditions within contemporary educational systems that affect their continued participation in the educational process offered within Atlantic Canada. Despite a variety of approaches developed by educators to address the high drop out rate and lack of interest in science, the statistics remain largely unchanged. Aboriginal educators are calling for a "new story" in education that better meets the needs of Aboriginal students. This study attempts to identify the conditions and contexts necessary to bridge the gap that currently exists for Aboriginal students in science studies. The research investigates the basic relationship between learning in general and the meaning-making processes engaged in by students of a Grade 7/8 class within a Mi'kmaw reserve school. It leads to a proposal for an alternative pedagogy, or a new narrative, for teaching science to Aboriginal students and the foundations for a culturally interactive science curriculum. For educators to understand the complexity of issues affecting Mi'kmaw student achievement in science requires a theoretical framework that allows the students' lived experience to emerge. Toward this end, the research includes both phenomenological and ethnographic approaches to understanding the lived experiences and cultural narratives based on interviews with the students, a field trip within the community, and a trial chemistry lesson. I examined how these students perceive themselves in different contexts and how their sense of identity establishes the meaningfulness of particular educational content. I also assessed how person, community/cultural and social contexts affect the students' learning. Part of creating this new narrative requires recognizing knowledge, including science, as a cultural product Taking this cultural view of scientific knowledge allows us to view learning as a process of identity formation and culture as a system of symbols

  10. Development-based Trust: Proposing and Validating a New Trust Measurement Model for Buyer-Seller Relationships

    Directory of Open Access Journals (Sweden)

    José Mauro da Costa Hernandez

    2010-04-01

    Full Text Available This study proposes and validates a trust measurement model for buyer-seller relationships. Baptized as development-based trust, the model encompasses three dimensions of trust: calculus-based, knowledge-based and identification-based. In addition to recognizing that trust is a multidimensional construct, the model also assumes that trust can evolve to take on a different character depending on the stage of the relationship. In order to test the proposed model and compare it to the characteristic-based trust measurement model, the measure most frequently used in the buyer-seller relationship literature, data were collected from 238 clients of an IT product wholesaler. The results show that the scales are valid and reliable and the proposed development-based trust measurement model is superior to the characteristic-based trust measurement model in terms of its ability to explain certain variables of interest in buyer-seller relationships (long-term relationship orientation, information sharing, behavioral loyalty and future intentions. Implications for practice, limitations and suggestions for future studies are discussed.

  11. Study on a model for future occupational health: proposal for an occupational health service model in Japan.

    Science.gov (United States)

    Higashi, Toshiaki

    2006-10-01

    The Study Model for Future Occupational Health (funded by a research grant from the Ministry of Health, Welfare and Labor) is a joint research project involving various organizations and agencies undertaken from 2002 to 2004. Society has undergone a dramatic transformation due to technological developments and internationalization. At the same time a low birth rate and an aging population have resulted in an increase in both the percentage of workers experiencing strong anxiety and stress in relation to their jobs and the working environment and the number of suicides. As a natural consequence, occupational health services are now expected to provide EAP, consulting and other functions that were formerly considered outside the realm of occupational health. In consideration of this background, the present study propose the following issues to provide a model for future occupational health services that meet the conditions presently confronted by each worker. 1. How to provide occupational health services and occupational physicians' services: 1) a basic time of 20 minutes of occupational health services per year should be allotted to each worker and to all workers; 2) the obligatory regulations should be revised to expand the obligation from businesses each with 50 or more employees under the present laws to businesses each with 30 or more employees. 2. Providers of occupational health services and occupational physicians' services: (1) reinforcement of outside occupational health agencies; (2) fostering occupational health consultant firms; (3) development of an institute of occupational safety and health; (4) support of activities by authorized occupational physicians in the field; (5) expanding of joint selection of occupational physicians including subsidy increase and the extension of a period of subsidy to five hears; (6) licensing of new entry into occupational health undertaking. 3. Introduction of new report system: (1) establishment of the obligation to

  12. In Pursuit of Social Betterment: A Proposal to Evaluate the Da Vinci Learning Model

    Science.gov (United States)

    Henry, Gary T.

    2005-01-01

    The author presents a proposal that is roughly based on a contingency-based theory of evaluation developed in his book, "Evaluation: An Integrated Framework for Understanding, Guiding, and Improving Policies and Programs" (Mark, Henry, and Julnes, 2000). He and his coauthors stated in this book that social betterment was the ultimate goal of…

  13. Absenteeism in Undergraduate Business Education: A Proposed Model and Exploratory Investigation

    Science.gov (United States)

    Burke, Lisa A.

    2010-01-01

    One issue in undergraduate business education remaining underexamined is student absenteeism. In this article, the literature on undergraduate absenteeism is reviewed culminating in a proposed conceptual framework to guide future research, and an exploratory investigation of management students' attitudes about absenteeism is conducted.…

  14. Biological consequences of earlier snowmelt from desert dust deposition in alpine landscapes.

    Science.gov (United States)

    Steltzer, Heidi; Landry, Chris; Painter, Thomas H; Anderson, Justin; Ayres, Edward

    2009-07-14

    Dust deposition to mountain snow cover, which has increased since the late 19(th) century, accelerates the rate of snowmelt by increasing the solar radiation absorbed by the snowpack. Snowmelt occurs earlier, but is decoupled from seasonal warming. Climate warming advances the timing of snowmelt and early season phenological events (e.g., the onset of greening and flowering); however, earlier snowmelt without warmer temperatures may have a different effect on phenology. Here, we report the results of a set of snowmelt manipulations in which radiation-absorbing fabric and the addition and removal of dust from the surface of the snowpack advanced or delayed snowmelt in the alpine tundra. These changes in the timing of snowmelt were superimposed on a system where the timing of snowmelt varies with topography and has been affected by increased dust loading. At the community level, phenology exhibited a threshold response to the timing of snowmelt. Greening and flowering were delayed before seasonal warming, after which there was a linear relationship between the date of snowmelt and the timing of phenological events. Consequently, the effects of earlier snowmelt on phenology differed in relation to topography, which resulted in increasing synchronicity in phenology across the alpine landscape with increasingly earlier snowmelt. The consequences of earlier snowmelt from increased dust deposition differ from climate warming and include delayed phenology, leading to synchronized growth and flowering across the landscape and the opportunity for altered species interactions, landscape-scale gene flow via pollination, and nutrient cycling.

  15. Proposed Robot Scheme with 5 DoF and Dynamic Modelling Using Maple Software

    Directory of Open Access Journals (Sweden)

    Shala Ahmet

    2017-11-01

    Full Text Available In this paper is represented Dynamical Modelling of robots which is commonly first important step of Modelling, Analysis and Control of robotic systems. This paper is focused on using Denavit-Hartenberg (DH convention for kinematics and Newton-Euler Formulations for dynamic modelling of 5 DoF - Degree of Freedom of 3D robot. The process of deriving of dynamical model is done using Software Maple. Derived Dynamical Model of 5 DoF robot is converted for Matlab use for future analysis, control and simulations.

  16. Proposed Model for a Streamlined, Cohesive, and Optimized K-12 STEM Curriculum with a Focus on Engineering

    Science.gov (United States)

    Locke, Edward

    2009-01-01

    This article presents a proposed model for a clear description of K-12 age-possible engineering knowledge content, in terms of the selection of analytic principles and predictive skills for various grades, based on the mastery of mathematics and science pre-requisites, as mandated by national or state performance standards; and a streamlined,…

  17. An analysis of a three-factor model proposed by the Danish Society of Actuaries for forecasting and risk analysis

    DEFF Research Database (Denmark)

    Jørgensen, Peter Løchte; Slipsager, Søren Kærgaard

    2016-01-01

    This paper provides the explicit solution to the three-factor diffusion model recently proposed by the Danish Society of Actuaries to the Danish industry of life insurance and pensions. The solution is obtained by use of the known general solution to multidimensional linear stochastic differential...

  18. Numerical Differentiation Methods for Computing Error Covariance Matrices in Item Response Theory Modeling: An Evaluation and a New Proposal

    Science.gov (United States)

    Tian, Wei; Cai, Li; Thissen, David; Xin, Tao

    2013-01-01

    In item response theory (IRT) modeling, the item parameter error covariance matrix plays a critical role in statistical inference procedures. When item parameters are estimated using the EM algorithm, the parameter error covariance matrix is not an automatic by-product of item calibration. Cai proposed the use of Supplemented EM algorithm for…

  19. New proposal of moderator temperature coefficient estimation method using gray-box model in NPP, (1)

    International Nuclear Information System (INIS)

    Mori, Michitsugu; Kagami, Yuichi; Kanemoto, Shigeru; Enomoto, Mitsuhiro; Tamaoki, Tetsuo; Kawamura, Shinichiro

    2004-01-01

    The purpose of the present paper is to establish a new void reactivity coefficient (VRC) estimation method based on gray box modeling concept. The gray box model consists of a point kinetics model as the first principle model and a fitting model of moderator temperature kinetics. Applying Kalman filter and maximum likehood estimation algorithms to the gray box model, MTC can be estimated. The verification test is done by Monte Carlo simulation, and, it is shown that the present method gives the best estimation results comparing with the conventional methods from the viewpoints of non-biased and smallest scattering estimation performance. Furthermore, the method is verified via real plant data analysis. The reason of good performance of the present method is explained by proper definition of likelihood function based on explicit expression of observation and system noise in the gray box model. (author)

  20. Recent gestational diabetes was associated with mothers stopping predominant breastfeeding earlier in a multi-ethnic population.

    Science.gov (United States)

    Baerug, Anne; Sletner, Line; Laake, Petter; Fretheim, Atle; Løland, Beate Fossum; Waage, Christin W; Birkeland, Kåre I; Jenum, Anne Karen

    2018-06-01

    It has previously been shown that breastfeeding may reduce the risk of type 2 diabetes in mothers with recent gestational diabetes mellitus (GDM). This study compared the cessation of predominant breastfeeding in mothers with and without recent GDM in a multi-ethnic population. From May 2008 to May 2010, healthy pregnant women attending antenatal care provided by community health services in Eastern Oslo, Norway were recruited. We included 616 women-58% non-Western-and interviewed and examined them at a mean of 15 and 28 weeks of gestation and 14 weeks' postpartum. Cox regression models examined the association between GDM, as assessed by the 2013 World Health Organization criteria, and breastfeeding cessation. Overall, 190 of the 616 (31%) mothers had GDM and they ended predominant breastfeeding earlier than mothers without GDM, with an adjusted hazard ratio (aHR) of 1.33 and 95% confidence interval (95% CI) of 1.01-1.77. Mothers of South Asian origin ended predominant breastfeeding earlier than Western European mothers in the adjusted analysis (aHR 1.53, 95% CI: 1.04-2.25), but Middle Eastern mothers did not. Recent gestational diabetes was associated with earlier cessation of predominant breastfeeding in Western European and non-Western women. ©2018 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  1. Daily Use, Especially of High-Potency Cannabis, Drives the Earlier Onset of Psychosis in Cannabis Users

    Science.gov (United States)

    Di Forti, Marta; Sallis, Hannah; Allegri, Fabio; Trotta, Antonella; Ferraro, Laura; Stilo, Simona A.; Marconi, Arianna; La Cascia, Caterina; Reis Marques, Tiago; Pariante, Carmine; Dazzan, Paola; Mondelli, Valeria; Paparelli, Alessandra; Kolliakou, Anna; Prata, Diana; Gaughran, Fiona; David, Anthony S.; Morgan, Craig; Stahl, Daniel; Khondoker, Mizanur; MacCabe, James H.; Murray, Robin M.

    2014-01-01

    Cannabis use is associated with an earlier age of onset of psychosis (AOP). However, the reasons for this remain debated. Methods: We applied a Cox proportional hazards model to 410 first-episode psychosis patients to investigate the association between gender, patterns of cannabis use, and AOP. Results: Patients with a history of cannabis use presented with their first episode of psychosis at a younger age (mean years = 28.2, SD = 8.0; median years = 27.1) than those who never used cannabis (mean years = 31.4, SD = 9.9; median years = 30.0; hazard ratio [HR] = 1.42; 95% CI: 1.16–1.74; P cannabis at age 15 or younger had an earlier onset of psychosis (mean years = 27.0, SD = 6.2; median years = 26.9) than those who had started after 15 years (mean years = 29.1, SD = 8.5; median years = 27.8; HR = 1.40; 95% CI: 1.06–1.84; P = .050). Importantly, subjects who had been using high-potency cannabis (skunk-type) every day had the earliest onset (mean years = 25.2, SD = 6.3; median years = 24.6) compared to never users among all the groups tested (HR = 1.99; 95% CI: 1.50- 2.65; P cannabis had an onset an average of 6 years earlier than that of non-cannabis users. Conclusions: Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users. PMID:24345517

  2. Collaborative Proposal: Transforming How Climate System Models are Used: A Global, Multi-Resolution Approach

    Energy Technology Data Exchange (ETDEWEB)

    Estep, Donald

    2013-04-15

    Despite the great interest in regional modeling for both weather and climate applications, regional modeling is not yet at the stage that it can be used routinely and effectively for climate modeling of the ocean. The overarching goal of this project is to transform how climate models are used by developing and implementing a robust, efficient, and accurate global approach to regional ocean modeling. To achieve this goal, we will use theoretical and computational means to resolve several basic modeling and algorithmic issues. The first task is to develop techniques for transitioning between parameterized and high-fidelity regional ocean models as the discretization grid transitions from coarse to fine regions. The second task is to develop estimates for the error in scientifically relevant quantities of interest that provide a systematic way to automatically determine where refinement is needed in order to obtain accurate simulations of dynamic and tracer transport in regional ocean models. The third task is to develop efficient, accurate, and robust time-stepping schemes for variable spatial resolution discretizations used in regional ocean models of dynamics and tracer transport. The fourth task is to develop frequency-dependent eddy viscosity finite element and discontinuous Galerkin methods and study their performance and effectiveness for simulation of dynamics and tracer transport in regional ocean models. These four projects share common difficulties and will be approach using a common computational and mathematical toolbox. This is a multidisciplinary project involving faculty and postdocs from Colorado State University, Florida State University, and Penn State University along with scientists from Los Alamos National Laboratory. The completion of the tasks listed within the discussion of the four sub-projects will go a long way towards meeting our goal of developing superior regional ocean models that will transform how climate system models are used.

  3. Later endogenous circadian temperature nadir relative to an earlier wake time in older people

    Science.gov (United States)

    Duffy, J. F.; Dijk, D. J.; Klerman, E. B.; Czeisler, C. A.

    1998-01-01

    The contribution of the circadian timing system to the age-related advance of sleep-wake timing was investigated in two experiments. In a constant routine protocol, we found that the average wake time and endogenous circadian phase of 44 older subjects were earlier than that of 101 young men. However, the earlier circadian phase of the older subjects actually occurred later relative to their habitual wake time than it did in young men. These results indicate that an age-related advance of circadian phase cannot fully account for the high prevalence of early morning awakening in healthy older people. In a second study, 13 older subjects and 10 young men were scheduled to a 28-h day, such that they were scheduled to sleep at many circadian phases. Self-reported awakening from scheduled sleep episodes and cognitive throughput during the second half of the wake episode varied markedly as a function of circadian phase in both groups. The rising phase of both rhythms was advanced in the older subjects, suggesting an age-related change in the circadian regulation of sleep-wake propensity. We hypothesize that under entrained conditions, these age-related changes in the relationship between circadian phase and wake time are likely associated with self-selected light exposure at an earlier circadian phase. This earlier exposure to light could account for the earlier clock hour to which the endogenous circadian pacemaker is entrained in older people and thereby further increase their propensity to awaken at an even earlier time.

  4. The impact of preventive maintenance practices on manufacturing performance: A proposed model for SMEs in Malaysia

    Science.gov (United States)

    Lazim, Halim Mad; Taib, Che Azlan; Lamsali, Hendrik; Saleh, Mohamed Najib; Subramaniam, Chandrakantan

    2016-08-01

    Preventive maintenance (PM) plays important role to avoid or mitigate potential stoppages and disruptions of equipment or machinery from occurring in daily operations. PM emphasized total employee involvement and it is important for companies as well as Small and Medium Sized Enterprises (SMEs). SME sectors contribution to the Malaysian economy makes up 95% of the total manufacturers, however PM remain relatively lacking. The ability, reliability and effective maintenance management is highly important in order to achieve desired manufacturing performance. Therefore, organizational capability in planning, controlling, implementing and monitoring PM activities is important. Furthermore, empirical evidence on the potential impact of PM practices towards manufacturing performance with organizational capability as a moderating effect is still limited and indecisive. Henceforth, this paper aims to explore and investigate potential relationships between PM practices and manufacturing performance moderated by organizational capability in the contact of Malaysian SMEs in the manufacturing sector. Correspondently, the study intends to propose a new research framework and hypotheses to examine the abovementioned relationships. The proposed framework includes PM team, PM strategy and planned maintenance as the determinants, while organizational capability serves as the moderating variable. Manufacturing performance will be viewed in terms of innovation and financial factors. Proposed research direction and conclusion are discussed at the end of the study.

  5. Earlier Right Ventricular Pacing in Cardiac Resynchronization Therapy for a Patient with Right Axis Deviation.

    Science.gov (United States)

    Hattori, Yusuke; Ishibashi, Kohei; Noda, Takashi; Okamura, Hideo; Kanzaki, Hideaki; Anzai, Toshihisa; Yasuda, Satoshi; Kusano, Kengo

    2017-09-01

    We describe the case of a 37-year-old woman who presented with complete right bundle branch block and right axis deviation. She was admitted to our hospital due to severe heart failure and was dependent on inotropic agents. Cardiac resynchronization therapy was initiated but did not improve her condition. After the optimization of the pacing timing, we performed earlier right ventricular pacing, which led to an improvement of her heart failure. Earlier right ventricular pacing should be considered in patients with complete right bundle branch block and right axis deviation when cardiac resynchronization therapy is not effective.

  6. Proposal for a Graded Authorisation Model for the Use of Ionising Radiation in Ireland

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-10-15

    The Radiological Protection Institute of Ireland RPII intends to refocus, streamline and modernise its regulation of the use of ionising radiation in Ireland. This report provides detailed proposals for establishing a graded approach to authorisation in which regulators will be able to focus on higher risk practices by simplifying requirements placed on those of lower risk, without compromising the safety or security of the Irish population. These proposals build on RPII strategic analyses that seek to navigate a course between the competing pressures of public sector reform and the rapid technological changes in medical and nuclear arenas, which challenge the licensing and advisory functions of RPII. A graded approach to authorisation provides the potential for a sustainable basis for future regulation in Ireland. Such an approach would be in line with the forthcoming EURATOM Basic Safety Standards and with general current regulatory trends, which are moving away from one-size-fits-all approaches towards more adaptive, interactive and transparent regulation. In seeking this reform, the RPII also aims to fully utilize the benefits of the internet and electronic communications and to improve the transparency of its processes. These proposals have been developed using a robust, comprehensive project methodology involving a root and branch analysis of current and potential future approaches to authorisation. A series of facilitated workshops were held, punctuated by intensive periods of focused co-enquiry, involving all members of the RPII Regulatory Service. This approach made the fullest use of the decades of expertise and knowledge of these staff. It also provided the platform for developing a common vision of a graded approach to authorisation; for agreeing the criteria for differentiating between levels of authorisation; for collecting the necessary evidence for decision-making and for identifying the implications of these decisions. The graded approach presented

  7. Proposal for a Graded Authorisation Model for the Use of Ionising Radiation in Ireland

    International Nuclear Information System (INIS)

    2012-10-01

    The Radiological Protection Institute of Ireland RPII intends to refocus, streamline and modernise its regulation of the use of ionising radiation in Ireland. This report provides detailed proposals for establishing a graded approach to authorisation in which regulators will be able to focus on higher risk practices by simplifying requirements placed on those of lower risk, without compromising the safety or security of the Irish population. These proposals build on RPII strategic analyses that seek to navigate a course between the competing pressures of public sector reform and the rapid technological changes in medical and nuclear arenas, which challenge the licensing and advisory functions of RPII. A graded approach to authorisation provides the potential for a sustainable basis for future regulation in Ireland. Such an approach would be in line with the forthcoming EURATOM Basic Safety Standards and with general current regulatory trends, which are moving away from one-size-fits-all approaches towards more adaptive, interactive and transparent regulation. In seeking this reform, the RPII also aims to fully utilize the benefits of the internet and electronic communications and to improve the transparency of its processes. These proposals have been developed using a robust, comprehensive project methodology involving a root and branch analysis of current and potential future approaches to authorisation. A series of facilitated workshops were held, punctuated by intensive periods of focused co-enquiry, involving all members of the RPII Regulatory Service. This approach made the fullest use of the decades of expertise and knowledge of these staff. It also provided the platform for developing a common vision of a graded approach to authorisation; for agreeing the criteria for differentiating between levels of authorisation; for collecting the necessary evidence for decision-making and for identifying the implications of these decisions. The graded approach presented

  8. Tourism Cluster Competitiveness and Sustainability: Proposal for a Systemic Model to Measure the Impact of Tourism on Local Development

    Directory of Open Access Journals (Sweden)

    Sieglinde Kindl da Cunha

    2005-07-01

    Full Text Available This article proposes a model to measure tourism cluster impact on local development with a view to assessing tourism cluster interaction, competitiveness and sustainability impacts on the economy, society and the environment. The theoretical basis for this model is founded on cluster concept and typology adapting and integrating the systemic competitiveness and sustainability concepts within economic, social, cultural, environmental and political dimensions. The proposed model shows a holistic, multidisciplinary and multi-sector view of local development brought back through a systemic approach to the concepts of competitiveness, social equity and sustainability. Its results make possible strategic guidance to agents responsible for public sector tourism policies, as well as the strategies for competitiveness, competition, cooperation and sustainability in private companies and institutions.

  9. Mathematical Modelling in Engineering: A Proposal to Introduce Linear Algebra Concepts

    Science.gov (United States)

    Cárcamo Bahamonde, Andrea; Gómez Urgelles, Joan; Fortuny Aymemí, Josep

    2016-01-01

    The modern dynamic world requires that basic science courses for engineering, including linear algebra, emphasise the development of mathematical abilities primarily associated with modelling and interpreting, which are not exclusively calculus abilities. Considering this, an instructional design was created based on mathematical modelling and…

  10. Inconsistency of Bayesian Inference for Misspecified Linear Models, and a Proposal for Repairing It

    NARCIS (Netherlands)

    Grünwald, P.; van Ommen, T.

    2017-01-01

    We empirically show that Bayesian inference can be inconsistent under misspecification in simple linear regression problems, both in a model averaging/selection and in a Bayesian ridge regression setting. We use the standard linear model, which assumes homoskedasticity, whereas the data are

  11. Inconsistency of Bayesian inference for misspecified linear models, and a proposal for repairing it

    NARCIS (Netherlands)

    P.D. Grünwald (Peter); T. van Ommen (Thijs)

    2017-01-01

    textabstractWe empirically show that Bayesian inference can be inconsistent under misspecification in simple linear regression problems, both in a model averaging/selection and in a Bayesian ridge regression setting. We use the standard linear model, which assumes homoskedasticity, whereas the data

  12. A Proposed Model of Retransformed Qualitative Data within a Mixed Methods Research Design

    Science.gov (United States)

    Palladino, John M.

    2009-01-01

    Most models of mixed methods research design provide equal emphasis of qualitative and quantitative data analyses and interpretation. Other models stress one method more than the other. The present article is a discourse about the investigator's decision to employ a mixed method design to examine special education teachers' advocacy and…

  13. Proposed development of a radionuclide washoff model for the German Reactor Safety Study

    International Nuclear Information System (INIS)

    Helton, J.C.

    1982-11-01

    This report presents a brief overview of the possible development of a model for the attenuation of radionuclide concentrations in urban environments due to rainfall/runoff relationships. The following sequence of actions is suggested: (1) preliminary review, (2) exploratory modeling, (3) detailed literature review, (4) development of mathematical model, (5) development of computer model, and (6) model review including verification and sensitivity analysis. To facilitate the initiation of the indicated efforts, an introduction to the relevant literature is provided. Further, the following topics are also briefly discussed: (1) radionuclide transport and removal in the terrestrial environment, (2) need for a description of the chemical and physical forms of the radionuclides released in a reactor accident, and (3) potential importance of surface-water contamination. (orig./HP) [de

  14. Proposals for measuring transversity distributions in deep inelastic electron scattering and a model for E-704 asymmetries

    International Nuclear Information System (INIS)

    Artru, X.

    1993-10-01

    The principles of the measurement of the quark transversity distributions in semi-inclusive deep inelastic electron scattering are presented, which form the basis of Hydrogen jet target in the LEP tunnel (HELP) and one of the European Laboratory For Electron (ELFE) proposals. A string model for Collins-type asymmetry in polarized quark fragmentation function is proposed. A possible role of the Collins effect in the single spin asymmetries observed by experiment E 704 at Fermilab is suggested. (author) 13 refs., 3 figs

  15. A self-report measure for the ICD-11 dimensional trait model proposal: The personality inventory for ICD-11.

    Science.gov (United States)

    Oltmanns, Joshua R; Widiger, Thomas A

    2018-02-01

    Proposed for the 11th edition of the World Health Organization's International Classification of Diseases (ICD-11) is a dimensional trait model for the classification of personality disorder (Tyrer, Reed, & Crawford, 2015). The ICD-11 proposal consists of 5 broad domains: negative affective, detachment, dissocial, disinhibition, and anankastic (Mulder, Horwood, Tyrer, Carter, & Joyce, 2016). Several field trials have examined this proposal, yet none has included a direct measure of the trait model. The purpose of the current study was to develop and provide initial validation for the Personality Inventory for ICD-11 (PiCD), a self-report measure of this proposed 5-domain maladaptive trait model. Item selection and scale construction proceeded through 3 initial data collections assessing potential item performance. Two subsequent studies were conducted for scale validation. In Study 1, the PiCD was evaluated in a sample of 259 MTurk participants (who were or had been receiving mental health treatment) with respect to 2 measures of general personality structure: The Eysenck Personality Questionnaire-Revised and the 5-Dimensional Personality Test. In Study 2, the PiCD was evaluated in an additional sample of 285 participants with respect to 2 measures of maladaptive personality traits: The Personality Inventory for DSM-5 and the Computerized Adaptive Test for Personality Disorders. Study 3 provides an item-level exploratory structural equation model with the combined samples from Studies 1 and 2. The results are discussed with respect to the validity of the measure and the potential benefits for future research in having a direct, self-report measure of the ICD-11 trait proposal. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  16. The respiratory tract deposition model proposed by the ICRP Task Group

    International Nuclear Information System (INIS)

    James, A.C.; Briant, J.K.; Stahlhofen, W.; Rudolf, G.; Gehr, P.

    1990-11-01

    The Task Group has developed a new model of the deposition of inhaled aerosols in each anatomical region of the respiratory tract. The model is used to evaluate the fraction of airborne activity that is deposited in respiratory regions having distinct retention characteristics and clearance pathways: the anterior nares, the extrathoracic airways of the naso- and oropharynx and larynx, the bronchi, the bronchioles, and the alveolated airways of the lung. Drawn from experimental data on total and regional deposition in human subjects, the model is based on extrapolation of these data by means of a detailed theoretical model of aerosol transport and deposition within the lung. The Task Group model applies to all practical conditions, and for aerosol particles and vapors from atomic size up to very coarse aerosols with an activity median aerodynamic diameter of 100 μm. The model is designed to predict regional deposition in different subjects, including adults of either sex, children of various ages, and infants, and also to account for anatomical differences among Caucasian and non-Caucasian subjects. The Task Group model represents aerosol inhalability and regional deposition in different subjects by algebraic expressions of aerosol size, breathing rates, standard lung volumes, and scaling factors for airway dimensions. 35 refs., 13 figs., 2 tabs

  17. Time-Dependent Toroidal Compactification Proposals and the Bianchi Type I Model: Classical and Quantum Solutions

    Directory of Open Access Journals (Sweden)

    L. Toledo Sesma

    2016-01-01

    Full Text Available We construct an effective four-dimensional model by compactifying a ten-dimensional theory of gravity coupled with a real scalar dilaton field on a time-dependent torus. This approach is applied to anisotropic cosmological Bianchi type I model for which we study the classical coupling of the anisotropic scale factors with the two real scalar moduli produced by the compactification process. Under this approach, we present an isotropization mechanism for the Bianchi I cosmological model through the analysis of the ratio between the anisotropic parameters and the volume of the Universe which in general keeps constant or runs into zero for late times. We also find that the presence of extra dimensions in this model can accelerate the isotropization process depending on the momenta moduli values. Finally, we present some solutions to the corresponding Wheeler-DeWitt (WDW equation in the context of standard quantum cosmology.

  18. A methodology proposal for collaborative business process elaboration using a model-driven approach

    Science.gov (United States)

    Mu, Wenxin; Bénaben, Frédérick; Pingaud, Hervé

    2015-05-01

    Business process management (BPM) principles are commonly used to improve processes within an organisation. But they can equally be applied to supporting the design of an Information System (IS). In a collaborative situation involving several partners, this type of BPM approach may be useful to support the design of a Mediation Information System (MIS), which would ensure interoperability between the partners' ISs (which are assumed to be service oriented). To achieve this objective, the first main task is to build a collaborative business process cartography. The aim of this article is to present a method for bringing together collaborative information and elaborating collaborative business processes from the information gathered (by using a collaborative situation framework, an organisational model, an informational model, a functional model and a metamodel and by using model transformation rules).

  19. Contextual Influences on Financial Behavior: A Proposed Model for Adult Financial Literacy Education

    Science.gov (United States)

    Way, Wendy L.

    2014-01-01

    This chapter presents an ecological model that highlights the importance of considering multiple contextual influences on behavior as well as other factors that may impact learning when designing research and practice aimed at enhancing financial capability.

  20. Interleukin-1 may link helplessness-hopelessness with cancer progression: A proposed model

    OpenAIRE

    Argaman, M; Gidron, Y; Ariad, S

    2005-01-01

    A model of the relations between psychological factors and cancer progression should include brain and systemic components and their link with critical cellular stages in cancer progression. We present a psychoneuroimmunological (PNI) model that links helplessness-hopelessness (HH) with cancer progression via interleukin-1β (IL-1β). IL-1β was elevated in the brain following exposure to inescapable shock, and HH was minimized by antagonizing cerebral IL-1β. Elevated cerebral IL-1β increased ca...

  1. Proposing a Model of Co-Regulated Learning for Graduate Medical Education.

    Science.gov (United States)

    Rich, Jessica V

    2017-08-01

    Primarily grounded in Zimmerman's social cognitive model of self-regulation, graduate medical education is guided by principles that self-regulated learning takes place within social context and influence, and that the social context and physical environment reciprocally influence persons and their cognition, behavior, and development. However, contemporary perspectives on self-regulation are moving beyond Zimmerman's triadic reciprocal orientation to models that consider social transactions as the central core of regulated learning. Such co-regulated learning models emphasize shared control of learning and the role more advanced others play in scaffolding novices' metacognitive engagement.Models of co-regulated learning describe social transactions as periods of distributed regulation among individuals, which instrumentally promote or inhibit the capacity for individuals to independently self-regulate. Social transactions with other regulators, including attending physicians, more experienced residents, and allied health care professionals, are known to mediate residents' learning and to support or hamper the development of their self-regulated learning competence. Given that social transactions are at the heart of learning-oriented assessment and entrustment decisions, an appreciation for co-regulated learning is likely important for advancing medical education research and practice-especially given the momentum of new innovations such as entrustable professional activities.In this article, the author explains why graduate medical educators should consider adopting a model of co-regulated learning to complement and extend Zimmerman's models of self-regulated learning. In doing so, the author suggests a model of co-regulated learning and provides practical examples of how the model is relevant to graduate medical education research and practice.

  2. Baseline requirements of the proposed action for the Transportation Management Division routing models

    International Nuclear Information System (INIS)

    Johnson, P.E.; Joy, D.S.

    1995-02-01

    The potential impacts associated with the transportation of hazardous materials are important to shippers, carriers, and the general public. This is particularly true for shipments of radioactive material. The shippers are primarily concerned with safety, security, efficiency, and equipment requirements. The carriers are concerned with the potential impact that radioactive shipments may have on their operations--particularly if such materials are involved in an accident. The general public has also expressed concerns regarding the safety of transporting radioactive and other hazardous materials through their communities. Because transportation routes are a central concern in hazardous material transport, the prediction of likely routes is the first step toward resolution of these issues. In response to these routing needs, several models have been developed over the past fifteen years at Oak Ridge National Laboratory (ORNL). The HIGHWAY routing model is used to predict routes for truck transportation, the INTERLINE routing model is used to predict both rail and barge routes, and the AIRPORT locator model is used to determine airports with specified criteria near a specific location. As part of the ongoing improvement of the US Department of Energy's (DOE) Environmental Management Transportation Management Division's (EM-261) computer systems and development efforts, a Baseline Requirements Assessment Session on the HIGHWAY, INTERLINE, and AIRPORT models was held at ORNL on April 27, 1994. The purpose of this meeting was to discuss the existing capabilities of the models and data bases and to review enhancements of the models and data bases to expand their usefulness. The results of the Baseline Requirements Assessment Section will be discussed in this report. The discussions pertaining to the different models are contained in separate sections

  3. An Empirical Based Proposal for Mass Customization Business Model in Footwear Industry

    OpenAIRE

    Pourabdollahian , Golboo; Corti , Donatella; Galbusera , Chiara; Silva , Julio ,

    2012-01-01

    Part 2: Design, Manufacturing and Production Management; International audience; This research aims at developing a business model for companies in the footwear industry interested in implementing Mass Customization with the goal of offering to the market products which perfectly match customers’ needs. The studies on mass customization are actually mostly focused on product development and production system aspects. This study extends the business modeling including also Supply Chain aspects...

  4. Smoking is associated with earlier time to revision of total knee arthroplasty.

    Science.gov (United States)

    Lim, Chin Tat; Goodman, Stuart B; Huddleston, James I; Harris, Alex H S; Bhowmick, Subhrojyoti; Maloney, William J; Amanatullah, Derek F

    2017-10-01

    Smoking is associated with early postoperative complications, increased length of hospital stay, and an increased risk of revision after total knee arthroplasty (TKA). However, the effect of smoking on time to revision TKA is unknown. A total of 619 primary TKAs referred to an academic tertiary center for revision TKA were retrospectively stratified according to the patient smoking status. Smoking status was then analyzed for associations with time to revision TKA using a Chi square test. The association was also analyzed according to the indication for revision TKA. Smokers (37/41, 90%) have an increased risk of earlier revision for any reason compared to non-smokers (274/357, 77%, p=0.031). Smokers (37/41, 90%) have an increased risk of earlier revision for any reason compared to ex-smokers (168/221, 76%, p=0.028). Subgroup analysis did not reveal a difference in indication for revision TKA (p>0.05). Smokers are at increased risk of earlier revision TKA when compared to non-smokers and ex-smokers. The risk for ex-smokers was similar to that of non-smokers. Smoking appears to have an all-or-none effect on earlier revision TKA as patients who smoked more did not have higher risk of early revision TKA. These results highlight the need for clinicians to urge patients not to begin smoking and encourage smokers to quit smoking prior to primary TKA. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Family history of atrial fibrillation is associated with earlier-onset and more symptomatic atrial fibrillation

    DEFF Research Database (Denmark)

    Gundlund, Anna; Fosbøl, Emil Loldrup; Kim, Sunghee

    2016-01-01

    BACKGROUND: We addressed whether patients with a family history of atrial fibrillation (AF) were diagnosed as having AF earlier in life, were more symptomatic, and had worse outcomes compared with those without a family history of AF. METHODS: Using the ORBIT-AF, we compared symptoms and disease...

  6. Optimal HIV testing and earlier care: the way forward in Europe

    DEFF Research Database (Denmark)

    Coenen, T; Lundgren, J; Lazarus, Jeff

    2008-01-01

    The articles in this supplement were developed from a recent pan-European conference entitled 'HIV in Europe 2007: Working together for optimal testing and earlier care', which took place on 26-27 November in Brussels, Belgium. The conference, organized by a multidisciplinary group of experts rep...

  7. Do BRCA1/2 mutation carriers have an earlier onset of natural menopause?

    NARCIS (Netherlands)

    van Tilborg, Theodora C.; Broekmans, Frank J.; Pijpe, Anouk; Schrijver, Lieske H.; Mooij, Thea M.; Oosterwijk, Jan C.; Verhoef, Senno; Garcia, Encarna B. Gomez; van Zelst-Stams, Wendy A.; Adank, Muriel A.; van Asperen, Christi J.; van Doorn, Helena C.; van Os, Theo A.; Bos, Anna M.; Rookus, Matti A.; Ausems, Margreet G.

    Objective: It has been hypothesized that BRCA1/2 mutation carriers have an earlier age at natural menopause (ANM), although to date findings are inconclusive. This study assessed the influence of BRCA mutation status on ANM, and aimed to explore the reasons of inconsistency in the literature.

  8. Earlier activity from XTE J1739-302/IGR J17391-3021 detected by INTEGRAL

    DEFF Research Database (Denmark)

    Chenevez, Jérôme; Beckmann, V.; Kuulkers, E.

    2008-01-01

    The recently reported outburst from the supergiant fast X-ray transient XTE J1739-302/IGR J17391-3021 (ATEL #1466) began already about five hours earlier than the Swift/BAT trigger on 2008-04-08. The INTEGRAL/JEM-X monitor detected a flare starting at 16:18 (UTC) on the same day during recent Gal...

  9. Use of metformin earlier in pregnancy predicts supplemental insulin therapy in women with gestational diabetes.

    Science.gov (United States)

    McGrath, Rachel T; Glastras, Sarah J; Hocking, Samantha; Fulcher, Gregory R

    2016-06-01

    The use of metformin in gestational diabetes is safe and effective, yet some women require additional insulin therapy to achieve glycaemic targets. We found a significant association between earlier gestational age at initiation of metformin therapy and the necessity for supplemental insulin in women treated with metformin during pregnancy. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  10. Place-Based Investment Model of Talent Development: A Proposed Model for Developing and Reinvesting Talents within the Community

    Science.gov (United States)

    Paul, Kristina Ayers; Seward, Kristen K.

    2016-01-01

    The place-based investment model (PBIM) of talent development is a programming model for developing talents of high-potential youth in ways that could serve as an investment in the community. In this article, we discuss the PBIM within rural contexts. The model is grounded in three theories--Moon's personal talent development theory, Sternberg's…

  11. A comparative study of the proposed models for the components of the national health information system.

    Science.gov (United States)

    Ahmadi, Maryam; Damanabi, Shahla; Sadoughi, Farahnaz

    2014-04-01

    National Health Information System plays an important role in ensuring timely and reliable access to Health information, which is essential for strategic and operational decisions that improve health, quality and effectiveness of health care. In other words, using the National Health information system you can improve the quality of health data, information and knowledge used to support decision making at all levels and areas of the health sector. Since full identification of the components of this system - for better planning and management influential factors of performanceseems necessary, therefore, in this study different attitudes towards components of this system are explored comparatively. This is a descriptive and comparative kind of study. The society includes printed and electronic documents containing components of the national health information system in three parts: input, process and output. In this context, search for information using library resources and internet search were conducted, and data analysis was expressed using comparative tables and qualitative data. The findings showed that there are three different perspectives presenting the components of national health information system Lippeveld and Sauerborn and Bodart model in 2000, Health Metrics Network (HMN) model from World Health Organization in 2008, and Gattini's 2009 model. All three models outlined above in the input (resources and structure) require components of management and leadership, planning and design programs, supply of staff, software and hardware facilities and equipment. Plus, in the "process" section from three models, we pointed up the actions ensuring the quality of health information system, and in output section, except for Lippeveld Model, two other models consider information products and use and distribution of information as components of the national health information system. the results showed that all the three models have had a brief discussion about the

  12. The Relationship between entrepreneurial orientation, entrepreneurial competencies, entrepreneurial leadership, and firm performance: A proposed model

    Directory of Open Access Journals (Sweden)

    Chijioke Nwachukwu

    2017-06-01

    Full Text Available This study develops a conceptual model and propositions for researchers to explore the direct and indirect relationship between entrepreneurial orientation, entrepreneurial competencies, entrepreneurial leadership and firm performance. Authors searched various databases including ProQuest, EBSCOhost databases, Scopus for peer reviewed Journals, books, and other relevant publications on the subject. A conceptual review provides direction for researchers to empirically examine the direct relationships between entrepreneurial orientation (EO, entrepreneurial competencies (EC, and firm performance and the mediating effect of entrepreneurial leadership (EL in the relationship between EO, EC, and firm performance. We suggest the use of entrepreneurial orientation scale (EOS, The entrecomp framework (2016, Renko et al., 2015 entrepreneurial leadership styles scale (ENTRELEAD, and Santos & Brito (2012 subjective measurement model for firm performance for measurement of the constructs of EO, EC, EL and performance. For researchers and academics, the model provides a basis for further research by testing empirically the validity of the model. Testing of this model could provide a better understanding of the EO, EC constructs that better predicts strategic and financial performance.

  13. Distinguishing between depression and anxiety: a proposal for an extension of the tripartite model.

    Science.gov (United States)

    den Hollander-Gijsman, M E; de Beurs, E; van der Wee, N J A; van Rood, Y R; Zitman, F G

    2010-05-01

    The aim of the current study was to develop scales that assess symptoms of depression and anxiety and can adequately differentiate between depression and anxiety disorders, and also can distinguish within anxiety disorders. As point of departure, we used the tripartite model of Clark and Watson that discerns three dimensions: negative affect, positive affect and physiological hyperarousal. Analyses were performed on the data of 1449 patients, who completed the Mood and Anxiety Symptoms Questionnaire (MASQ) and the Brief Symptom Inventory (BSI). From this, 1434 patients were assessed with a standardized diagnostic interview. A model with five dimensions was found: depressed mood, lack of positive affect, somatic arousal, phobic fear and hostility. The scales appear capable to differentiate between patients with a mood and with an anxiety disorder. Within the anxiety disorders, somatic arousal was specific for patients with panic disorder. Phobic fear was associated with panic disorder, simple phobia and social anxiety disorder, but not with generalized anxiety disorder. We present a five-factor model as an extension of the tripartite model. Through the addition of phobic fear, anxiety is better represented than in the tripartite model. The new scales are capable to accurately differentiate between depression and anxiety disorders, as well as between several anxiety disorders. (c) 2009 Elsevier Masson SAS. All rights reserved.

  14. Proposing a Compartmental Model for Leprosy and Parameterizing Using Regional Incidence in Brazil.

    Science.gov (United States)

    Smith, Rebecca Lee

    2016-08-01

    Hansen's disease (HD), or leprosy, is still considered a public health risk in much of Brazil. Understanding the dynamics of the infection at a regional level can aid in identification of targets to improve control. A compartmental continuous-time model for leprosy dynamics was designed based on understanding of the biology of the infection. The transmission coefficients for the model and the rate of detection were fit for each region using Approximate Bayesian Computation applied to paucibacillary and multibacillary incidence data over the period of 2000 to 2010, and model fit was validated on incidence data from 2011 to 2012. Regional variation was noted in detection rate, with cases in the Midwest estimated to be infectious for 10 years prior to detection compared to 5 years for most other regions. Posterior predictions for the model estimated that elimination of leprosy as a public health risk would require, on average, 44-45 years in the three regions with the highest prevalence. The model is easily adaptable to other settings, and can be studied to determine the efficacy of improved case finding on leprosy control.

  15. On the development of LWR fuel analysis code (1). Analysis of the FEMAXI code and proposal of a new model

    International Nuclear Information System (INIS)

    Lemehov, Sergei; Suzuki, Motoe

    2000-01-01

    This report summarizes the review on the modeling features of FEMAXI code and proposal of a new theoretical equation model of clad creep on the basis of irradiation-induced microstructure change. It was pointed out that plutonium build-up in fuel matrix and non-uniform radial power profile at high burn-up affect significantly fuel behavior through the interconnected effects with such phenomena as clad irradiation-induced creep, fission gas release, fuel thermal conductivity degradation, rim porous band formation and associated fuel swelling. Therefore, these combined effects should be properly incorporated into the models of the FEMAXI code so that the code can carry out numerical analysis at the level of accuracy and elaboration that modern experimental data obtained in test reactors have. Also, the proposed new mechanistic clad creep model has a general formalism which allows the model to be flexibly applied for clad behavior analysis under normal operation conditions and power transients as well for Zr-based clad materials by the use of established out-of-pile mechanical properties. The model has been tested against experimental data, while further verification is needed with specific emphasis on power ramps and transients. (author)

  16. Proposal of a new biokinetic model for niobium; Proposta de um novo modelo biocinetico para o niobio

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Roges

    2006-07-01

    There are two niobium isotopes generated in nuclear power plants: 95 Nb and 94 Nb. Workers and members of the public are subjects to intake these radionuclides in accident situation. For dose calculation purpose, it is very important to develop a model that describes in a more realistic way the kinetics of niobium inside of the human body. Presently the model adopted by ICRP (ICRP, 1989) is based on animal studies and describes the behavior of niobium in human being in a simple manner. The new model proposal describes the kinetics of the niobium from the intake into the blood until the excretion, doing this in a more realistic form and considering not only data from animals but data from human beings as well. For this objective, a workers group of a niobium extraction and processing industry exposed to stable niobium (93 Nb) in oxide insoluble form with associated uranium, was monitored for uranium and niobium determination in urinary and fecal excretion, by mass spectrometry. Based in the ratios of the niobium concentration in urinary and faecal excretion of this workers and animal data study, a new biokinetic model for niobium was proposed, with the followings modifications relative to ICRP model: a new compartment that represents muscular tissue; the fractions which are deposited into the compartment are modified; a third component in the retention equation of the bone tissue; introduction of recirculation between organs and blood. The new model was applied for a case of accidental intake and described adequately the experimental data.

  17. Proposed Pharmacological Countermeasures Against Apoptotic Cell Death in Experimental Models Mimicking Space Environment Damage

    Science.gov (United States)

    Lulli, Matteo; Papucci, Laura; Witort, Ewa; Donnini, Martino; Lapucci, Andrea; Lazzarano, Stefano; Mazzoni, Tiziano; Simoncini, Madine; Falciani, Piergiuseppe; Capaccioli, Sergio

    2008-06-01

    Several damaging agents have been suggested to affect human vision during long term space travels. Recently, apoptosis induced by DNA-damaging agents has emerged as frequent pathogenetic mechanism of ophthalmologic pathologies. Here, we propose two countermeasures: coenzyme Q10 and bcl-2 downregulation preventing antisense oligoribonucleotides (ORNs), aimed to inhibit cellular apoptotic death. Our studies have been carried out on retina and neuronal cultured cells treated with the following apoptotic stimuli mimicking space environment: a several-day exposure to either 3H-labeled tymidine or to the genotoxic drug doxorubicin, UV irradiation, hypoxia and glucose/growth factor starvation (Locke medium). The preliminary results clearly indicate that CoQ10, as well as bcl-2 down-regulation preventing ORNs, significantly counteract apoptosis in response to different DNA damaging agents in cultured eye and in neuronal cells. This supports the possibility that both could be optimal countermeasures against ophthalmologic lesions during space explorations.

  18. A proposed adaptive step size perturbation and observation maximum power point tracking algorithm based on photovoltaic system modeling

    Science.gov (United States)

    Huang, Yu

    Solar energy becomes one of the major alternative renewable energy options for its huge abundance and accessibility. Due to the intermittent nature, the high demand of Maximum Power Point Tracking (MPPT) techniques exists when a Photovoltaic (PV) system is used to extract energy from the sunlight. This thesis proposed an advanced Perturbation and Observation (P&O) algorithm aiming for relatively practical circumstances. Firstly, a practical PV system model is studied with determining the series and shunt resistances which are neglected in some research. Moreover, in this proposed algorithm, the duty ratio of a boost DC-DC converter is the object of the perturbation deploying input impedance conversion to achieve working voltage adjustment. Based on the control strategy, the adaptive duty ratio step size P&O algorithm is proposed with major modifications made for sharp insolation change as well as low insolation scenarios. Matlab/Simulink simulation for PV model, boost converter control strategy and various MPPT process is conducted step by step. The proposed adaptive P&O algorithm is validated by the simulation results and detail analysis of sharp insolation changes, low insolation condition and continuous insolation variation.

  19. Mathematical modelling in engineering: A proposal to introduce linear algebra concepts

    Directory of Open Access Journals (Sweden)

    Andrea Dorila Cárcamo

    2016-03-01

    Full Text Available The modern dynamic world requires that basic science courses for engineering, including linear algebra, emphasize the development of mathematical abilities primarily associated with modelling and interpreting, which aren´t limited only to calculus abilities. Considering this, an instructional design was elaborated based on mathematic modelling and emerging heuristic models for the construction of specific linear algebra concepts:  span and spanning set. This was applied to first year engineering students. Results suggest that this type of instructional design contributes to the construction of these mathematical concepts and can also favour first year engineering students understanding of key linear algebra concepts and potentiate the development of higher order skills.

  20. Management of information in development projects – a proposed integrated model

    Directory of Open Access Journals (Sweden)

    C. Bester

    2008-11-01

    Full Text Available The first section of the article focuses on the need for development in Africa and the specific challenges of development operations. It describes the need for a holistic and integrated information management model as part of the project management body of knowledge aimed at managing the information flow between communities and development project teams. It is argued that information, and access to information, is crucial in development projects and can therefore be seen as a critical success factor in any development project. In the second section of the article, the three information areas of the holistic and integrated information management model are described. In the section thereafter we suggest roles and actions for information managers to facilitate information processes integral to the model. These processes seek to create a developing information community that aligns itself with the development project, and supports and sustains it.

  1. Conceptual Nuclear Design Of Two Models Of Research Reactor Proposed For Vietnam

    International Nuclear Information System (INIS)

    Nguyen Nhi Dien; Huynh Ton Nghiem; Le Vinh Vinh; Vo Doan Hai Dang

    2007-01-01

    The joint study on the development of a new research reactor model for Vietnam was done. The KAERI (Korea Atomic Energy Research Institute) experts and DNRI (Dalat Nuclear Research Institute) researchers developed an advanced HANARO reactor (AHR), a 20-MW open-tank-in-pool type reactor, upward cooled and moderated by light water, reflected by heavy water and rod type fuel assemblies used. Based on the AHR model, a MTR reactor with plate fuel assemblies was developed. Computer codes named MCNP and MVP/BURN were used. Major analyses have been done for the relevant nuclear design parameters such as the neutron flux and power distributions, reactivity coefficients, control rod worth, etc. in both with clean, unperturbed core and equilibrium core condition. In case of AHR model, calculation results using MVP/BURN and MCNP codes were compared with the results using HELIOS and MCNP codes by KAERI experts and they are in a good agreement. (author)

  2. Toward a new model of scientific publishing: Discussion and a proposal

    Directory of Open Access Journals (Sweden)

    Dwight eKravitz

    2011-12-01

    Full Text Available The current system of publishing in the neurosciences, is notable for its redundancy, inconsistency, sluggishness, and opacity. These problems persist, and grow worse, because of a continuing failure to fully leverage new technology. Online access has eliminated space limits within peer-reviewed journals, yet we continue to deny publication. Each submission of a rejected manuscript requires the entire machinery of peer review to creak to life. This redundancy causes delays, inconsistency, and increases the burden on authors, reviewers, and editors. Further, reviewers serve a key role in the process but their performance is not tracked; yet alone rewarded. This misalignment of incentives contributes to the inconsistency and sluggishness that pervades peer review. The current system also interferes with the primary purpose of modern journals, providing a quick way of prioritizing the literature. Reviews are written to gauge publication rather than scientific merit and there is no guarantee that the journal’s criteria agree with those of an individual researcher, making any prioritization opaque and noisy at best.The focus of this special issue is the future form of post-publication reception, and the development of a marketplace where a paper rises and falls based on its reception from the field. However, the information that accompanies a paper into the marketplace is as important as the marketplace’s mechanics. Beyond suggestions as to the mechanisms of reception, we propose an update to the system of publishing in which publication is guaranteed, but pre-publication peer review still occurs, giving the authors the opportunity to revise their work following a mini pre-reception from the field. This step also provides a consistent set of rankings and reviews to the marketplace, allowing for early prioritization and stabilizing its early dynamics. We further propose to improve the general quality of reviewing by providing tangible rewards to

  3. A proposal of parameter determination method in the residual strength degradation model for the prediction of fatigue life (I)

    International Nuclear Information System (INIS)

    Kim, Sang Tae; Jang, Seong Soo

    2001-01-01

    The static and fatigue tests have been carried out to verify the validity of a generalized residual strength degradation model. And a new method of parameter determination in the model is verified experimentally to account for the effect of tension-compression fatigue loading of spheroidal graphite cast iron. It is shown that the correlation between the experimental results and the theoretical prediction on the statistical distribution of fatigue life by using the proposed method is very reasonable. Furthermore, it is found that the correlation between the theoretical prediction and the experimental results of fatigue life in case of tension-tension fatigue data in composite material appears to be reasonable. Therefore, the proposed method is more adjustable in the determination of the parameter than maximum likelihood method and minimization technique

  4. Antimanic efficacy of retigabine in a proposed mouse model of bipolar disorder

    DEFF Research Database (Denmark)

    Nielsen, Ditte Dencker; Bak-Jensen, Henriette Husum

    2010-01-01

    use of amphetamine in humans can result in depression symptoms it was explored if a state of anhedonia could be assessed by testing saccharine preference before and during the withdrawal period of the model. The tested antimanic drugs (lithium, valproate, carbamazepine and lamotrigine) all attenuated...

  5. A Proposal to Elicit Usability Requirements within a Model-Driven Development Environment

    NARCIS (Netherlands)

    Isela Ormeno, Y; Panach, I; Condori-Fernandez, O.N.; Pastor, O.

    2014-01-01

    Nowadays there are sound Model-Driven Development (MDD) methods that deal with functional requirements, but in general, usability is not considered from the early stages of the development. Analysts that work with MDD implement usability features manually once the code has been generated. This

  6. Models Provide Specificity: Testing a Proposed Mechanism of Visual Working Memory Capacity Development

    Science.gov (United States)

    Simmering, Vanessa R.; Patterson, Rebecca

    2012-01-01

    Numerous studies have established that visual working memory has a limited capacity that increases during childhood. However, debate continues over the source of capacity limits and its developmental increase. Simmering (2008) adapted a computational model of spatial cognitive development, the Dynamic Field Theory, to explain not only the source…

  7. A review of international pharmacy-based minor ailment services and proposed service design model.

    Science.gov (United States)

    Aly, Mariyam; García-Cárdenas, Victoria; Williams, Kylie; Benrimoj, Shalom I

    2018-01-05

    The need to consider sustainable healthcare solutions is essential. An innovative strategy used to promote minor ailment care is the utilisation of community pharmacists to deliver minor ailment services (MASs). Promoting higher levels of self-care can potentially reduce the strain on existing resources. To explore the features of international MASs, including their similarities and differences, and consider the essential elements to design a MAS model. A grey literature search strategy was completed in June 2017 to comply with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses standard. This included (1) Google/Yahoo! search engines, (2) targeted websites, and (3) contact with commissioning organisations. Executive summaries, table of contents and title pages of documents were reviewed. Key characteristics of MASs were extracted and a MAS model was developed. A total of 147 publications were included in the review. Key service elements identified included eligibility, accessibility, staff involvement, reimbursement systems. Several factors need to be considered when designing a MAS model; including contextualisation of MAS to the market. Stakeholder engagement, service planning, governance, implementation and review have emerged as key aspects involved with a design model. MASs differ in their structural parameters. Consideration of these parameters is necessary when devising MAS aims and assessing outcomes to promote sustainability and success of the service. Copyright © 2018 Elsevier Inc. All rights reserved.

  8. Analyzing “Etka Chain Stores” Strategies and Proposing Optimal Strategies; Using SWOT Model based on Fuzzy Logic

    OpenAIRE

    Mohammad Aghaei; Amin Asadollahi; Elham Vahedi; Mahdi Pirooz

    2013-01-01

    To maintain and achieve optimal growth, development and to be more competitive, organizations need a comprehensive and coherent plan compatible with their objectives and goals which is called strategic planning. This research aims to analyse strategically “Etka Chain Stores” and to propose optimal strategies by using SWOT model and based on fuzzy logic. The scope of this research is limited to “Etka Chain stores in Tehran”. As instrumentation, a questioner, consisting of 138 questions, was us...

  9. An analysis of a three-factor model proposed by the Danish Society of Actuaries for forecasting and risk analysis

    OpenAIRE

    Jørgensen, Peter Løchte; Slipsager, Søren Kærgaard

    2016-01-01

    This paper provides the explicit solution to the three-factor diffusion model recently proposed by the Danish Society of Actuaries to the Danish industry of life insurance and pensions. The solution is obtained by use of the known general solution to multidimensional linear stochastic differential equation systems. With offset in the explicit solution, we establish the conditional distribution of the future state variables which allows for exact simulation. Using exact simulation, we illustra...

  10. Sports Management for Sports Massification Planned and Executed by Social Organizations. Critics to Models, Experiences and Proposal Methodological Accompaniment

    OpenAIRE

    Lorenza Antonia Reyes de Duran

    2016-01-01

    The proposal analysis, interpretation, disassembly, self-criticism and guidance is born and comes from work experience planned mass sports and social organizations opposed-not in the conventional sense comparative-private business models and sport, state and management. The contribution made by the sports management experience from positions of power, either state or business are undeniable and its impact is difficult to express in numbers for its humanistic value, which is incalculable. Howe...

  11. PTM Modeling of Dredged Suspended Sediment at Proposed Polaris Point and Ship Repair Facility CVN Berthing Sites - Apra Harbor, Guam

    Science.gov (United States)

    2017-09-01

    sedimentation outside of the channel footprint. For example, dredging near the edge of the footprint can be confined to time periods when tidal currents...Cases 1 or 2 due to the lower loss rate. Sedimentation rates outside the channel prism are further reduced because all sediment is introduced in the...ER D C/ CH L TR -1 7- 16 PTM Modeling of Dredged Suspended Sediment at Proposed Polaris Point and Ship Repair Facility CVN Berthing

  12. Proposing a Hybrid Model Based on Robson's Classification for Better Impact on Trends of Cesarean Deliveries.

    Science.gov (United States)

    Hans, Punit; Rohatgi, Renu

    2017-06-01

    To construct a hybrid model classification for cesarean section (CS) deliveries based on the woman-characteristics (Robson's classification with additional layers of indications for CS, keeping in view low-resource settings available in India). This is a cross-sectional study conducted at Nalanda Medical College, Patna. All the women delivered from January 2016 to May 2016 in the labor ward were included. Results obtained were compared with the values obtained for India, from secondary analysis of WHO multi-country survey (2010-2011) by Joshua Vogel and colleagues' study published in "The Lancet Global Health." The three classifications (indication-based, Robson's and hybrid model) applied for categorization of the cesarean deliveries from the same sample of data and a semiqualitative evaluations done, considering the main characteristics, strengths and weaknesses of each classification system. The total number of women delivered during study period was 1462, out of which CS deliveries were 471. Overall, CS rate calculated for NMCH, hospital in this specified period, was 32.21% ( p  = 0.001). Hybrid model scored 23/23, and scores of Robson classification and indication-based classification were 21/23 and 10/23, respectively. Single-study centre and referral bias are the limitations of the study. Given the flexibility of the classifications, we constructed a hybrid model based on the woman-characteristics system with additional layers of other classification. Indication-based classification answers why, Robson classification answers on whom, while through our hybrid model we get to know why and on whom cesarean deliveries are being performed.

  13. Cernavoda Unit 2: - BOP 3D model proposal for a possible organization of site activities

    International Nuclear Information System (INIS)

    Ghiesura, G.; Scarsin, Sioli; Orlandi, S.

    1999-01-01

    The scope of this activity is to define characteristics and advantages of the 3D model of Cernavoda BOP to this set up at site for engineering and construction activities. This model will provide a modern and proven tool able to strongly support the site activities with particular regard to the following: 1. engineering activities, - plant arrangement 'double check' for resolution of clashing; - easy management of future design changes; - real time plant configuration updating as soon as any design modification is approved and integrated in the model; - preparation of high quality documentation for procurement, construction and commissioning; - prompt availability of the as built configuration of the plant as soon as the last modification is frozen; 2. material procurement activities, - definition of the priorities in the construction material procurement according to the construction planning by area; - inventory list of equipment, pipes, fittings, valves, cable trays and ventilation ducts to be installed in each construction area; 3. construction activities, - definition of construction sequences, with particular reference in the congested areas, for piping cable trays (electrical and C-and-I) and ventilations ducts; - definition of piping spools by construction contractors; - follow-up of the activities in each area (i.e. construction, painting, insulation, flushing, pressure testing, etc); 4. turn-over and commissioning, - check of the progress. The success of this approach is based on the following: i) proper management of the remote workstations providing easy and reliable access to the model; ii) subdivision of the Integrated Building in construction areas, whose detail design may be allotted to Romanian organizations with multidisciplinary tasks; iii) integration in the model of the remote developed engineering in order to validate the details of the design. (authors)

  14. Equivalent flow rate concept used in near field transport model COMP23 - Proposed values for SR 97

    International Nuclear Information System (INIS)

    Moreno, L.

    1998-11-01

    SKB is using NUCTRAN to calculate transport of radionuclides from a possible defective canister into the far field. NUCTRAN is included in the Performance Assessment model chain that calculates the release from the canister into the biosphere. In the chain, NUCTRAN is denoted COMP23. In order to calculate the transport of radionuclides by diffusion into the flowing water in the rock, NUCTRAN uses the concept of equivalent flow rate, Q eq . To calculate the value of Q eq in the different paths, COMP23 needs information about the Darcy velocity, the geometry of the system, material properties and the flow porosity in the rock. At present, this information is supplied to COMP23 by means of three parameters. The aim of this note is to propose a method to calculate the flow equivalent within the SR 97 project. Estimated intervals of the factors to adopt HYDRASTAR results to COMP23 are presented. Since it is difficult to give general validity to the factors, solely proposed factor intervals are presented to obtain equivalent flow rate values for COMP23. To obtain accurate equivalent flow rate values, information about the hydraulic conditions at canister locations in the groundwater model should be available for the near field model or the Q eq values could be calculated directly in the groundwater flow model. One of the main tasks in the SR 97 project is to show the barrier performance of the rock using different alternative models for flow and transport. In addition, the Alternative Model Project (AMP) aims to show how robust the assessment model description is, in terms of relevant far field performance measures. In the AMP, three main approaches were used, namely, the Stochastic Continuum approach, the Channel Network model and the Discrete Feature Network model

  15. A Proposed Educational Model to Improve the Operations of Knowledge-Exchange between MOE and Higher Education Institutions in Jordan

    Directory of Open Access Journals (Sweden)

    Husni Ana,am Ali Salem

    2017-12-01

    Full Text Available The purpose of this study was to build a proposed educational model for improving knowledge-exchange processes between the Ministry of Education and Higher Education institutions in Jordan. The sample of the study consisted of (301 educational leaders: (158 academic staff members from the Faculty of Educational Sciences – University of Jordan – and the Faculty of Education in Yarmouk University; and (143 members from the center of Jordanian Ministry of Education for the academic year 2016/2017. To achieve the aims of the study, the researcher built a questionnaire, consisting of (88 items as tool for collecting data. The research tool was checked for its validity and reliability semantics. To analyze the data, means and standard deviation were used. The results of the study showed that the educational leaders rated the degree of practicing knowledge-exchange processes between Jordanian Ministry of Education and Higher Education institutions in Jordan as (moderate. Also, they rated the obstacles that face knowledge-exchange processes as (moderate. The study concluded with a proposed educational model for improving knowledge-exchange processes between the Ministry of Education and Higher Education institutions in Jordan, and recommended to be approved and applied in Jordan. Keywords: A Proposed educational model, Knowledge-exchange processes, Practicing degree, Obstacles, Jordanian Universities, Jordanian Ministry of Education

  16. What Factors Lead Companies to Adopt Social Media in their processes: Proposal and Test of a Measurement Model

    Directory of Open Access Journals (Sweden)

    Jozé Braz de Araújo

    2016-01-01

    Full Text Available The objective of this study was to understand which factors lead companies to use social media to achieve results. For that, a theoretical model was proposed and tested. Data was collected using a survey of 237 companies. In the analysis we analysis used the structural eq uation modeling technique. The results show that the social media relative advantage and its observability were important factors to social media organizational adoption. We also found that big companies with more formalized organizational structure (OS t end to adopt social media more than small ones with no formal OS. The companies studied showed strong organizational disposition for innovation adoption.

  17. [The carrier model of neurology in Hungary: a proposal for the solution until 2020].

    Science.gov (United States)

    Bereczki, Dániel; Csiba, László; Komoly, Sámuel; Vécsei, László; Ajtay, András

    2011-11-30

    Based on our previous survey on the capacities of neurological services and on the predictable changes in the neurologist workforce in Hungary, we present a proposal for the organization of the structure of neurological services in the future. We discuss the diagnostic groups treated by neurologists, the neurological services and their progressive organization. Using the current capacities as baseline, we propose patient groups to be treated by neurologists in the future, and the levels of services. Based on the tendencies seen in the last years we suggest to consider to allocate acute stroke services exclusively to stroke units in neurological departments, and we identify a few other diagnostic groups where neurology should have a larger share in patient care. We define three levels for inpatient care: university departments, regional/county hospitals, city hospitals. Instead of minimum criteria we assign outpatient and inpatient standards that are functional from the economic point of view as well. University departments cover all areas of neurological services, have a function in graduate and postgraduate training, and on a regional basis they participate in professional quality assurance activities at the county and city hospital levels, and would have a more independent role in residency training. As far as patient care is concerned, the task of the regional/county hospitals would be similar to that of university departments - without the exclusively university functions. A general neurological service would be offered at the city hospital level - the representation of all subspecialties of neurology is not required. Neurorehabilitation would be organized at special units of neurological wards at the city hospital level, at independent neurorehabilitation wards in regional/county hospitals, and also as an outpatient service offered at the patients' home. The most significant organizational change would affect the outpatient neurological services. In addition

  18. Formation of calcareous nodules in loess-paleosol sequences: Reviews of existing models with a proposed new "per evapotranspiration model"

    Science.gov (United States)

    Li, Yanrong; Zhang, Weiwei; Aydin, Adnan; Deng, Xiaohong

    2018-04-01

    Loess is a product of aeolian deposition during Quaternary glaciation cycles. Loess-paleosol sequences are rich in calcareous nodules (CNs). In the literature, two models are widely cited for the formation of CNs, namely "per descendum" and "per ascendum". However, there has been no direct testing or monitoring to support either of these contradictory models. This paper reviews a large number of multidisciplinary literature to evaluate the consistency, reliability and rationality of these two models. Three main conclusions are drawn: (1) the causative factors (variation of pH value along loess-paleosol sequence, decrease of CO2 partial pressure, and reduction of solvent water) that are used to support the per descendum model do not completely explain the supersaturation of infiltration solution with CaCO3, thereby making this model questionable; (2) the per ascendum model explains the formation of CNs along narrow horizons through upward evaporation; however, it fails to produce sporadic distributions and irregular shapes of nodules on loess slope faces and the frequent appearance of nodules around plant roots. In order to reconcile these deficiencies, we conducted an extensive field survey in various parts of Shanxi province. Based on this new set of observations, it was concluded that the "per ascendum" model can be extended to explain all occurrences of CNs. This extended model is called "per evapotranspiration".

  19. Modeling oscillatory dynamics in brain microcircuits as a way to help uncover neurological disease mechanisms: A proposal

    Energy Technology Data Exchange (ETDEWEB)

    Skinner, F. K. [Toronto Western Research Institute, University Health Network, Krembil Discovery Tower, Toronto Western Hospital, 60 Leonard Street, 7th floor, 7KD411, Toronto, Ontario M5T 2S8 (Canada); Department of Medicine (Neurology), University of Toronto, 200 Elizabeth Street, Toronto, Ontario M5G 2C4 (Canada); Department of Physiology, University of Toronto Medical Sciences Building, 3rd Floor, 1 King' s College Circle, Toronto, Ontario M5S 1A8 (Canada); Ferguson, K. A. [Toronto Western Research Institute, University Health Network, Krembil Discovery Tower, Toronto Western Hospital, 60 Leonard Street, 7th floor, 7KD411, Toronto, Ontario M5T 2S8 (Canada); Department of Physiology, University of Toronto Medical Sciences Building, 3rd Floor, 1 King' s College Circle, Toronto, Ontario M5S 1A8 (Canada)

    2013-12-15

    There is an undisputed need and requirement for theoretical and computational studies in Neuroscience today. Furthermore, it is clear that oscillatory dynamical output from brain networks is representative of various behavioural states, and it is becoming clear that one could consider these outputs as measures of normal and pathological brain states. Although mathematical modeling of oscillatory dynamics in the context of neurological disease exists, it is a highly challenging endeavour because of the many levels of organization in the nervous system. This challenge is coupled with the increasing knowledge of cellular specificity and network dysfunction that is associated with disease. Recently, whole hippocampus in vitro preparations from control animals have been shown to spontaneously express oscillatory activities. In addition, when using preparations derived from animal models of disease, these activities show particular alterations. These preparations present an opportunity to address challenges involved with using models to gain insight because of easier access to simultaneous cellular and network measurements, and pharmacological modulations. We propose that by developing and using models with direct links to experiment at multiple levels, which at least include cellular and microcircuit, a cycling can be set up and used to help us determine critical mechanisms underlying neurological disease. We illustrate our proposal using our previously developed inhibitory network models in the context of these whole hippocampus preparations and show the importance of having direct links at multiple levels.

  20. Interleukin-1 may link helplessness-hopelessness with cancer progression: a proposed model.

    Science.gov (United States)

    Argaman, Miriam; Gidron, Yori; Ariad, Shmuel

    2005-01-01

    A model of the relations between psychological factors and cancer progression should include brain and systemic components and their link with critical cellular stages in cancer progression. We present a psychoneuroimmunological (PNI) model that links helplessness-hopelessness (HH) with cancer progression via interleukin-1beta (IL-1beta). IL-1beta was elevated in the brain following exposure to inescapable shock, and HH was minimized by antagonizing cerebral IL-1beta. Elevated cerebral IL-1beta increased cancer metastasis in animals. Inescapable shock was associated with systemic elevations of IL-1beta and peripheral IL-1beta was associated with escape from apoptosis, angiogenesis, and metastasis. Involvement of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis are discussed. Future studies need to identify the role of additional factors in this PNI pathway.

  1. Proposing an Aggregate Production Planning Model by Goal Programming Approach, a Case Study

    Directory of Open Access Journals (Sweden)

    Mansoureh Farzam Rad

    2014-06-01

    Full Text Available Production planning is one of the most important functions in the process of production management. Production planning in the intermediate range of time is termed as aggregate production planning (APP. Aggregate production planning is an important upper level planning activity in a production management system. The present study tries to suggest an aggregate production planning model for products of Hafez tile factory during one year. Due to this fact that the director of the company seeks 3 main objectives to determine the optimal production rate, the linear goal planning method was employed. After solving the problem, in order to examine the efficiency and the distinctiveness of this method in compare to linear programming, the problem was modeled just by considering one objective then was solved by linear programming approach. The findings revealed the goal programming with multi objectives resulted more appropriate solution rather than linear programming with just one objective.

  2. A Proposed Model for Measuring Performance of the University-Industry Collaboration in Open Innovation

    OpenAIRE

    Anca Draghici; Larisa Ivascu; Adrian Mateescu; George Draghici

    2017-01-01

    The paper aims to present a scientific approach to the creation, testing and validation of a model for performance measurement for university-industry collaboration (UIC). The main idea of the design process is to capitalize on existing success factors, facilitators and opportunities (motivation factors, knowledge transfer channels and identified benefits) and to diminish or avoid potential threats and barriers that might interfere with such collaborations. The main purpose ...

  3. Proposing a Model for Successful Application of Knowledge Sharing II (Social Knowledge Sharing) within Organizations

    OpenAIRE

    Mehdi Shamizanjani; Seyed Mohammad Ghasemtabar Shahri

    2014-01-01

    The main purpose of this research is the development of a success model of Knowledge Sharing 2.0 (social knowledge sharing) through organizations. A three-step strategy is used in this research as stated below: In the first step, identification of social software and extraction of factors effective on success of each for knowledge sharing were obtained from literature review. Execution of Delphi method and identification of critical factors were done in the second step. At l...

  4. Silver Entrepreneurship Agenda in Malaysia: A Proposed Model for Productive Aging

    Directory of Open Access Journals (Sweden)

    Aizzat Mohd Nasurdin

    2012-03-01

    Full Text Available This paper aims at proposing a framework for productive aging among those aged 45-plus or retiree via entrepreneurial initiatives, known as ‘silver entrepreneurs’. Evidence has shown that the number of Malaysians aged population is estimated to be more than 1.4 million and is projected to increase to 3.3 million in the year 2020 (Mafauzy, 2000. It is acknowledged that a group of these will comprise of professionals who are aged 45-plus and retirees with relevant industry experience as well as knowledge and well-established networks built up over their working careers which will enable them to effectively identify entrepreneurial opportunities and secure resources efficiently to exploit them. However, there is little research on and understanding of what drives these ‘silver entrepreneurs’, with most of the research, focussed on entrepreneurial ventures started by 18-35 year-olds.  This means that policy-makers are ill-equipped to develop specific measures that will assist retirees into a second or sunset career in entrepreneurship.  This research aims to bridge the gap by assessing the profile and motivations of silver entrepreneurs in Malaysia with a specific focus on understanding the internal and external factors that affect their intentions to start new ventures as well as factors that affect the success and growth of these ventures. 

  5. A proposal for a determination method of element division on an analytical model for finite element elastic waves propagation analysis

    International Nuclear Information System (INIS)

    Ishida, Hitoshi; Meshii, Toshiyuki

    2010-01-01

    This study proposes an element size selection method named the 'Impact-Meshing (IM) method' for a finite element waves propagation analysis model, which is characterized by (1) determination of element division of the model with strain energy in the whole model, (2) static analysis (dynamic analysis in a single time step) with boundary conditions which gives a maximum change of displacement in the time increment and inertial (impact) force caused by the displacement change. In this paper, an example of application of the IM method to 3D ultrasonic wave propagation problem in an elastic solid is described. These examples showed an analysis result with a model determined by the IM method was convergence and calculation time for determination of element subdivision was reduced to about 1/6 by the IM Method which did not need determination of element subdivision by a dynamic transient analysis with 100 time steps. (author)

  6. Is Smaller Better? A Proposal to Use Bacteria For Neuroscientific Modeling

    Directory of Open Access Journals (Sweden)

    Archana Ram

    2018-02-01

    Full Text Available Bacteria are easily characterizable model organisms with an impressively complicated set of abilities. Among them is quorum sensing, a cell-cell signaling system that may have a common evolutionary origin with eukaryotic cell-cell signaling. The two systems are behaviorally similar, but quorum sensing in bacteria is more easily studied in depth than cell-cell signaling in eukaryotes. Because of this comparative ease of study, bacterial dynamics are also more suited to direct interpretation than eukaryotic dynamics, e.g., those of the neuron. Here we review literature on neuron-like qualities of bacterial colonies and biofilms, including ion-based and hormonal signaling, and a phenomenon similar to the graded action potential. This suggests that bacteria could be used to help create more accurate and detailed biological models in neuroscientific research. More speculatively, bacterial systems may be considered an analog for neurons in biologically based computational research, allowing models to better harness the tremendous ability of biological organisms to process information and make decisions.

  7. A Proposal for the Time Domain Modeling of Split Air Conditioners for Consumer Reimbursement Studies

    Science.gov (United States)

    Rezende, Paulo Henrique Oliveira; Almeida Junior, Afonso Bernardino; Gondim, Isaque Nogueira; Oliveira, José Carlos

    2015-04-01

    This paper deals with computer application procedures for the evaluation of the causal consistency between anomalous phenomena manifested in electrical networks, along with the physical damage associated with electrical equipment and possible reimbursement requests. The focus is on the development of an air conditioner appliance model of the type known as split founded upon a representation, in the time domain, in accordance with the Alternative Transients Program (ATP) simulator requirements. This approach permits investigations concerning the performance of the product when submitted to ideal and non-ideal supply conditions. Once the equipment model is implemented in the program, a set of investigative studies are carried out to show the device performance under specific energy quality disturbance conditions. In addition, there are still the results for the validation of the process established through the correlation between computational performance of the air conditioner with corresponding studies carried out experimentally, which are presented herein. Moreover, once the effectiveness of the developed model is verified, it is implemented into the Requests for Reimbursement Software. Investigations related to the correlation between disturbances and the levels of thermal and dielectric tolerance are then performed aiming at illustrating the use of the research results for the reimbursement analyzes purposes.

  8. The adoption of sustainable innovations: The role of instrumental, environmental, and symbolic attributes for earlier and later adopters

    NARCIS (Netherlands)

    H. Noppers, E.; Keizer, K.; Bockarjova, M.; Steg, L.

    2015-01-01

    We investigated motivations of potential earlier and later adopters for adopting sustainable innovations. A large questionnaire study revealed that potential earlier adopters of innovative cars evaluated the symbolic attributes of electric cars, but not the instrumental and environmental attributes,

  9. Reduction of Glucose Metabolism in Olfactory Bulb is an Earlier Alzheimer's Disease-related Biomarker in 5XFAD Mice

    Directory of Open Access Journals (Sweden)

    Nai-An Xiao

    2015-01-01

    Conclusions: The decline of (18F-FDG uptake in the olfactory bulb occurs earlier than other incidents, serving as an earlier in vivo biological marker of AD in 5XFAD mice and making early diagnosis of AD possibly.

  10. Effective Solar Indices for Ionospheric Modeling: A Review and a Proposal for a Real-Time Regional IRI

    Science.gov (United States)

    Pignalberi, A.; Pezzopane, M.; Rizzi, R.; Galkin, I.

    2018-01-01

    The first part of this paper reviews methods using effective solar indices to update a background ionospheric model focusing on those employing the Kriging method to perform the spatial interpolation. Then, it proposes a method to update the International Reference Ionosphere (IRI) model through the assimilation of data collected by a European ionosonde network. The method, called International Reference Ionosphere UPdate (IRI UP), that can potentially operate in real time, is mathematically described and validated for the period 9-25 March 2015 (a time window including the well-known St. Patrick storm occurred on 17 March), using IRI and IRI Real Time Assimilative Model (IRTAM) models as the reference. It relies on foF2 and M(3000)F2 ionospheric characteristics, recorded routinely by a network of 12 European ionosonde stations, which are used to calculate for each station effective values of IRI indices IG_{12} and R_{12} (identified as IG_{{12{eff}}} and R_{{12{eff}}}); then, starting from this discrete dataset of values, two-dimensional (2D) maps of IG_{{12{eff}}} and R_{{12{eff}}} are generated through the universal Kriging method. Five variogram models are proposed and tested statistically to select the best performer for each effective index. Then, computed maps of IG_{{12{eff}}} and R_{{12{eff}}} are used in the IRI model to synthesize updated values of foF2 and hmF2. To evaluate the ability of the proposed method to reproduce rapid local changes that are common under disturbed conditions, quality metrics are calculated for two test stations whose measurements were not assimilated in IRI UP, Fairford (51.7°N, 1.5°W) and San Vito (40.6°N, 17.8°E), for IRI, IRI UP, and IRTAM models. The proposed method turns out to be very effective under highly disturbed conditions, with significant improvements of the foF2 representation and noticeable improvements of the hmF2 one. Important improvements have been verified also for quiet and moderately disturbed

  11. Hydrogeologic modelling in support of a proposed Deep Geologic Repository in Canada for low and intermediate level radioactive waste

    Energy Technology Data Exchange (ETDEWEB)

    Sykes, J.F.; Normani, S.D.; Yin, Y. [Waterloo Univ., ON (Canada). Dept. of Civil and Environmental Engineering; Sykes, E.A.; Jensen, M.R. [Nuclear Waste Management Organization, Toronto, ON (Canada)

    2009-07-01

    Ontario Power Generation (OPG) has proposed the construction of a Deep Geologic Repository (DGR) for low and intermediate level radioactive waste at the Bruce site on the shore of Lake Huron near Tiverton, Ontario. The DGR is to be excavated at a depth of about 680 m within argillaceous limestones of Ordovician age. A saturated regional-scale and site-scale numerical modelling study has been completed in order to evaluate the safety of storing radioactive waste at the site and to better understand the geochemistry and hydrogeology of the formations surrounding the proposed DGR. This paper reported on the regional-scale base-case modelling and analysis of the measured pressure profile in deep boreholes at the DGR site. The numerical modelling study provided a framework to investigate the groundwater flow system as it relates to, and potentially affects, the safety and long-term performance of the DGR. A saturated groundwater flow model was also developed using FRAC3DVS-OPG. The objective of regional-scale groundwater modelling of the Paleozoic sedimentary sequence underlying southwestern Ontario was to provide a basis for the assembly and integration of site-specific geoscientific data and to explain the influence of parameter and scenario uncertainty on predicted long-term geosphere barrier performance. The base-case analysis showed that solute transport in the Ordovician and lower Silurian is diffusion dominant. For the base-case parameters, the estimated mean life expectancy for the proposed DGR is more than 8 million years. The possible presence of a gas phase in the rock between the Cambrian and the Niagaran was not considered in the analyses of this paper. 9 refs., 2 tabs., 10 figs.

  12. Compulsive Buying: Earlier Illicit Drug Use, Impulse Buying, Depression, and Adult ADHD Symptoms

    Science.gov (United States)

    Brook, Judith S.; Zhang, Chenshu; Brook, David W.; Leukefeld, Carl G.

    2015-01-01

    This longitudinal study examined the association between psychosocial antecedents, including illicit drug use, and adult compulsive buying (CB) across a 29-year time period from mean age 14 to mean age 43. Participants originally came from a community-based random sample of residents in two upstate New York counties. Multivariate linear regression analysis was used to study the relationship between the participant’s earlier psychosocial antecedents and adult CB in the fifth decade of life. The results of the multivariate linear regression analyses showed that gender (female), earlier adult impulse buying (IB), depressive mood, illicit drug use, and concurrent ADHD symptoms were all significantly associated with adult CB at mean age 43. It is important that clinicians treating CB in adults should consider the role of drug use, symptoms of ADHD, IB, depression, and family factors in CB. PMID:26165963

  13. Evaluation of the safety of the operating nuclear power plants built to earlier standards

    International Nuclear Information System (INIS)

    Menteseoglu, S.

    2001-01-01

    The objective of this paper is to provide practical assistance on judging the safety of a nuclear power plant, on the basis of a comparison with current safety standards and operational practices. For nuclear power plants built to earlier standards for which there are questions about the adequacy of the maintenance of the plant design and operational practices, a safety review against current standards and practices can be considered a high priority. The objective of reviewing nuclear power plants built to earlier standards against current standards and practices is to determine whether there are any deviations which would have an impact on plant safety. The safety significance of the issues identified should be judged according to their implications for plant design and operation in terms of basic safety concepts such as defence in depth and safety culture. In addition, this paper provides assistance on the prioritization of corrective measures and their implementation so as to approach an acceptable level of safety

  14. Compulsive buying: Earlier illicit drug use, impulse buying, depression, and adult ADHD symptoms.

    Science.gov (United States)

    Brook, Judith S; Zhang, Chenshu; Brook, David W; Leukefeld, Carl G

    2015-08-30

    This longitudinal study examined the association between psychosocial antecedents, including illicit drug use, and adult compulsive buying (CB) across a 29-year time period from mean age 14 to mean age 43. Participants originally came from a community-based random sample of residents in two upstate New York counties. Multivariate linear regression analysis was used to study the relationship between the participant's earlier psychosocial antecedents and adult CB in the fifth decade of life. The results of the multivariate linear regression analyses showed that gender (female), earlier adult impulse buying (IB), depressive mood, illicit drug use, and concurrent ADHD symptoms were all significantly associated with adult CB at mean age 43. It is important that clinicians treating CB in adults should consider the role of drug use, symptoms of ADHD, IB, depression, and family factors in CB. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  15. A vantage from space can detect earlier drought onset: an approach using relative humidity.

    Science.gov (United States)

    Farahmand, Alireza; AghaKouchak, Amir; Teixeira, Joao

    2015-02-25

    Each year, droughts cause significant economic and agricultural losses across the world. The early warning and onset detection of drought is of particular importance for effective agriculture and water resource management. Previous studies show that the Standard Precipitation Index (SPI), a measure of precipitation deficit, detects drought onset earlier than other indicators. Here we show that satellite-based near surface air relative humidity data can further improve drought onset detection and early warning. This paper introduces the Standardized Relative Humidity Index (SRHI) based on the NASA Atmospheric Infrared Sounder (AIRS) observations. The results indicate that the SRHI typically detects the drought onset earlier than the SPI. While the AIRS mission was not originally designed for drought monitoring, we show that its relative humidity data offers a new and unique avenue for drought monitoring and early warning. We conclude that the early warning aspects of SRHI may have merit for integration into current drought monitoring systems.

  16. Evaluation of risks associated with nuclear facilities: Variation of results according to the models proposed

    International Nuclear Information System (INIS)

    Hubert, Ph.

    1983-01-01

    The methods employed in evaluating radiological risk are based, by and large, on the non-threshold linear relationships proposed by the ICRP and the Advisory Committee on the Biological Effects of Ionizing Radiations (BEIR) of the US Academy of Sciences in its 1972 report. Recently, the contentious discussions surrounding the latest BEIR report and the publication of new estimates of the doses received at Hiroshima and Nagasaki have reopened the controversy surrounding dose-effect relationships. The chief point at issue is the shape of this relationship - whether or not it is linear and whether it has a threshold - and the role of radiation in carcinogenesis, both in association with other risk factors and as an independent factor. The present paper leaves the theoretical questions aside and instead shows how, by marshalling information on irradiated human populations, a sequence of calculations can be set up to enable specialists to assign numerical values to the coefficients for these relationships. In an empirical approach such as this, theoretical hypotheses are no longer the sole factors at work. Comparatively pragmatic choices, such as the sample on the basis of which the curves are adjusted, the survival tables used, or even the simplifications made in taking account of sex and age, can also influence the result obtained. Sensitivity analyses are presented for the value of the coefficient of cancer induction per unit dose, showing that controversial theoretical options such as the transformation of a linear into a quadratic linear relationship have no greater effect on the result than other more contingent choices. Lastly, the implications of these sensitivity analyses for the practical application of dose-risk relationships are examined in relation to impact studies, optimization procedures, etc. (author)

  17. Proposing Telecardiology Services on Cloud for Different Medical Institutions: A Model of Reference.

    Science.gov (United States)

    de la Torre-Díez, Isabel; Garcia-Zapirain, Begoña; López-Coronado, Miguel; Rodrigues, Joel J P C

    2017-08-01

    For a cloud-based telecardiology solution to be established in any scenario, it is necessary to ensure optimum levels of security, as patient's data will not be in the same place from where access is gained. The main objective of this article is to present a secure, cloud-based solution for a telecardiology service in different scenarios: a hospital, a health center in a city, and a group of health centers in a rural area. iCanCloud software is used to simulate the scenarios. The first scenario will be a city hospital with over 220,000 patients at its emergency services, and ∼1 million outpatient consultations. For the health center in a city, it serves ∼107,000 medical consultations and 16,700 pediatric consultations/year. In the last scenario, a group of health centers in a rural area serve an average 437.08 consultations/month and around 15.6 a day. Each one of the solutions proposed shares common features including the following: secure authentication through smart cards, the use of StorageGRID technology, and load balancers. For all cases, the cloud is private and the estimated price of the solution would cost around 450 €/month. Thanks to the research conducted in this work, it has been possible to provide an adapted solution in the form of a telecardiology service for a hospital, city health center, and rural health centers that offer security, privacy, and robustness, and is also optimum for a large number of cloud requests.

  18. Estimation of parasitic losses in a proposed mesoscale resonant engine: Experiment and model

    Science.gov (United States)

    Preetham, B. S.; Anderson, M.; Richards, C.

    2014-02-01

    A resonant engine in which the piston-cylinder assembly is replaced by a flexible cavity is realized at the mesoscale using flexible metal bellows to demonstrate the feasibility of the concept. A four stroke motoring technique is developed and measurements are performed to determine parasitic losses. A non-linear lumped parameter model is developed to evaluate the engine performance. Experimentally, the heat transfer and friction effects are separated by varying the engine speed and operating frequency. The engine energy flow diagram showing the energy distribution among various parasitic elements reveals that the friction loss in the bellows is smaller than the sliding friction loss in a typical piston-cylinder assembly.

  19. A proposed study on the transplacental transport of parabens in the human placental perfusion model

    DEFF Research Database (Denmark)

    Mathiesen, Line; Zuri, Giuseppina; Andersen, Maria H

    2013-01-01

    , but the available data are sparse. The aim is to develop a method for estimating fetal exposure, via the placenta, to the most commonly-used parabens, by using a human placental perfusion model. The use of human tissue is vital for determining human fetal exposure, because animal studies are of little relevance...... to determine the transport kinetics of these parabens across the human placenta, and to investigate placental metabolism, including differences in transport due to molecular characteristics. This will facilitate assessment of the risks associated with the use of paraben-containing products during pregnancy....

  20. Respect for the complexity of human learning: a proposal for a new model of teacher training

    Directory of Open Access Journals (Sweden)

    Lori R. Muskat

    1998-02-01

    Full Text Available "Inclusion" is hard to implement worldwide. In the U.S.A. and Canada, one obstacle is the division between "general" and "special" education. To facilitate inclusion of exceptional students, a new model of teacher training is needed. This piece introduces the System for Understanding Individual Learning Performance (S.U.I.L.P.. Derived from neuropsychology, cross-cultural psychology, education, and sociology, the S.U.I.L.P. provides a holistic framework and common vocabulary for understanding learning performance in all learners--across development and different contexts. It also establishes avenues for collaboration and eventual merging of general and special education.

  1. Non-adversarial justice and the coroner's court: a proposed therapeutic, restorative, problem-solving model.

    Science.gov (United States)

    King, Michael S

    2008-12-01

    Increasingly courts are using new approaches that promote a more comprehensive resolution of legal problems, minimise any negative effects that legal processes have on participant wellbeing and/or that use legal processes to promote participant wellbeing. Therapeutic jurisprudence, restorative justice, mediation and problem-solving courts are examples. This article suggests a model for the use of these processes in the coroner's court to minimise negative effects of coroner's court processes on the bereaved and to promote a more comprehensive resolution of matters at issue, including the determination of the cause of death and the public health and safety promotion role of the coroner.

  2. Bringing Emotions into Legal Education Through the Experimental Learning Model: A Proposal

    OpenAIRE

    Lidia Rodak

    2017-01-01

    The paper calls for the integration of theory and practice in legal education through integrating emotions into learning process. The ideas it aims to put forward have their roots in the work of the American educational psychologist, David A. Kolb. Using the Experiential Learning Theory Model, he elaborated on, the paper demonstrates how it can be adapted to suit legal education and what the benefits are for legal education.Este artículo propone integrar la teoría y la prá...

  3. A Hepatocellular Carcinoma Case in a Patient Who had Immunity to Hepatitis B Virus Earlier.

    Science.gov (United States)

    Ates, Ihsan; Kaplan, Mustafa; Demirci, Selim; Altiparmak, Emin

    2016-01-01

    Hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver. Hepatitis B virus infection is one of the most important etilogical factors of HCC. In this case report, a patient with HCC previously infected and having ongoing immunity against hepatitis B virus will be discussed. Ates I, Kaplan M, Demirci S, Altiparmak E. A Hepatocellular Carcinoma Case in a Patient Who had Immunity to Hepatitis B Virus Earlier. Euroasian J Hepato-Gastroenterol 2016;6(1):82-83.

  4. Earlier adolescent substance use onset predicts stronger connectivity between reward and cognitive control brain networks

    Directory of Open Access Journals (Sweden)

    David G. Weissman

    2015-12-01

    Discussion: The regions that demonstrated significant positive linear relationships between the number of adolescent years using substances and connectivity with NAcc are nodes in the right frontoparietal network, which is central to cognitive control. The coupling of reward and cognitive control networks may be a mechanism through which earlier onset of substance use is related to brain function over time, a trajectory that may be implicated in subsequent substance use disorders.

  5. XML-based formulation of field theoretical models. A proposal for a future standard and data base for model storage, exchange and cross-checking of results

    International Nuclear Information System (INIS)

    Demichev, A.; Kryukov, A.; Rodionov, A.

    2002-01-01

    We propose an XML-based standard for formulation of field theoretical models. The goal of creation of such a standard is to provide a way for an unambiguous exchange and cross-checking of results of computer calculations in high energy physics. At the moment, the suggested standard implies that models under consideration are of the SM or MSSM type (i.e., they are just SM or MSSM, their submodels, smooth modifications or straightforward generalizations). (author)

  6. Model validation and the role of the proposed Rock Characterisation Facility at Sellafield. Proof of evidence

    International Nuclear Information System (INIS)

    Wallace, H.

    1996-01-01

    Proof of Evidence is given by an expert witness on behalf of Greenpeace Ltd as part of their submission to a Planning Inquiry in 1995 hearing the application of UK Nirex Ltd for permission to construct an underground Rock Characterisation Facility (RCF) at a site near Sellafield. The RCF is part of an investigation by Nirex into a suitable site for the disposal of radioactive waste. An examination of the groundwater flow models used by Nirex and the procedure for their validation have led to the following conclusions: no evidence has been presented by Nirex to show that the construction of the RCF will improve the confidence they claim to have in the site; the prospects are slim for validating the models of present groundwater flow so that they satisfy the criteria to meet the risk target; it is extremely unlikely that results from the RCF will increase confidence in a safety assessment of this site; all the evidence available to date suggests that the risk assessment is not, and will not become, robust to variations in flux through the repository. (1 figure; 8 references). (UK)

  7. Net modelling of energy mix among European Countries: A proposal for ruling new scenarios

    International Nuclear Information System (INIS)

    Dassisti, M.; Carnimeo, L.

    2012-01-01

    European energy policy pursues the objective of a sustainable, competitive and secure supply of energy. In 2007, the European Commission adopted an energy policy for Europe, which was supported by several documents on different aspects of energy and included an action plan to meet the major energy challenges Europe has to face. A farsighted diversified yearly mix of energies was suggested to countries, aiming at increasing security of supply and efficiency, but a wide and contemporary view of energy interchanges between states was not available. In a previous work of the same authors, energy import/export interchanges between European States were used to develop a geographic overview at one-glance. In this paper, the enhanced Interchange Energy Network (IEN) is investigated from a modelling point of view, as a Small-World Net, by supposing that connections can exist between States with a probability depending also on economic/political relations between countries. -- Highlights: ► Different view of the imports and exports of electric energy flows between European for potential use in ruling exchanges. ► Panel data from 1996 to 2008 as part of a network of exchanges was considered from Eurostat official database. ► The European import/export energy flows modelled as a network with Small-World phenomena, interpreting the evolution over the years. ► Interesting behavioural features as outcome derived, as shown for the case example of the Germany.

  8. RAMI modeling of selected balance of plant systems for the proposed Accelerator Production of Tritium (APT) project

    International Nuclear Information System (INIS)

    Radder, J.A.; Cramer, D.S.

    1997-01-01

    In order to meet Department of Energy (DOE) Defense Program requirements for tritium in the 2005-2007 time frame, new production capability must be made available. The Accelerator Production of Tritium (APT) Plant is being considered as an alternative to nuclear reactor production of tritium, which has been the preferred method in the past. The proposed APT plant will use a high-power proton accelerator to generate thermal neutrons that will be captured in 3 He to produce tritium (3H). It is expected that the APT Plant will be built and operated at the DOE's Savannah River Site (SRS) in Aiken, South Carolina. Discussion is focused on Reliability, Availability, Maintainability, and Inspectability (RAMI) modeling of recent conceptual designs for balance of plant (BOP) systems in the proposed APT Plant. In the conceptual designs for balance of plant (BOP) systems in the proposed APT Plant. In the conceptual design phase, system RAMI estimates are necessary to identify the best possible system alternative and to provide a valid picture of the cost effectiveness of the proposed system for comparison with other system alternatives. RAMI estimates in the phase must necessarily be based on generic data. The objective of the RAMI analyses at the conceptual design stage is to assist the designers in achieving an optimum design which balances the reliability and maintainability requirements among the subsystems and components

  9. Do emotional support and classroom organization earlier in the year set the stage for higher quality instruction?

    Science.gov (United States)

    Curby, Timothy W; Rimm-Kaufman, Sara E; Abry, Tashia

    2013-10-01

    Many teachers believe that providing greater emotional and organizational supports in the beginning of the year strengthens their ability to teach effectively as the year progresses. Some interventions, such as the Responsive Classroom (RC) approach, explicitly embed this sequence into professional development efforts. We tested the hypothesis that earlier emotional and organizational supports set the stage for improved instruction later in the year in a sample of third- and fourth-grade teachers enrolled in a randomized controlled trial of the RC approach. Further, we examined the extent to which the model generalized for teachers using varying levels of RC practices as well as whether or not teachers were in the intervention or control groups. Teachers' emotional, organizational, and instructional interactions were observed using the Classroom Assessment Scoring System (Pianta, La Paro, & Hamre, 2008) on five occasions throughout the year. Results indicated a reciprocal relation between emotional and instructional supports. Specifically, higher levels of emotional support earlier in the year predicted higher instructional support later in the year. Also, higher levels of instructional support earlier in the year predicted higher emotional support later in the year. Classroom organization was not found to have longitudinal associations with the other domains across a year. This pattern was robust when controlling for the use of RC practices as well as across intervention and control groups. Further, teachers' use of RC practices predicted higher emotional support and classroom organization throughout the year, suggesting the malleability of this teacher characteristic. Discussion highlights the connection between teachers' emotional and instructional supports and how the use of RC practices improves teachers' emotionally supportive interactions with students. Copyright © 2013 Society for the Study of School Psychology. Published by Elsevier Ltd. All rights

  10. Evaluating the impact a proposed family planning model would have on maternal and infant mortality in Afghanistan.

    Science.gov (United States)

    Rahmani, Ahmad Masoud; Wade, Benjamin; Riley, William

    2015-01-01

    This study aimed to assess the potential impact a proposed family planning model would have on reducing maternal and infant mortality in Afghanistan. Afghanistan has a high total fertility rate, high infant mortality rate, and high maternal mortality rate. Afghanistan also has tremendous socio-cultural barriers to and misconceptions about family planning services. We applied predictive statistical models to a proposed family planning model for Afghanistan to better understand the impact increased family planning can have on Afghanistan's maternal mortality rate and infant mortality rate. We further developed a sensitivity analysis that illustrates the number of maternal and infant deaths that can be averted over 5 years according to different increases in contraceptive prevalence rates. Incrementally increasing contraceptive prevalence rates in Afghanistan from 10% to 60% over the course of 5 years could prevent 11,653 maternal deaths and 317,084 infant deaths, a total of 328,737 maternal and infant deaths averted. Achieving goals in reducing maternal and infant mortality rates in Afghanistan requires a culturally relevant approach to family planning that will be supported by the population. The family planning model for Afghanistan presents such a solution and holds the potential to prevent hundreds of thousands of deaths. Copyright © 2013 John Wiley & Sons, Ltd.

  11. Proposing a Qualitative Approach for Corporate Competitive Capability Modeling in High-Tech Business (Case study: Software Industry

    Directory of Open Access Journals (Sweden)

    Mahmoud Saremi Saremi

    2010-09-01

    Full Text Available The evolution of global business trend for ICT-based products in recent decades shows the intensive activity of pioneer developing countries to gain a powerful competitive position in global software industry. In this research, with regard to importance of competition issue for top managers of Iranian software companies, a conceptual model has been developed for Corporate Competitive Capability concept. First, after describing the research problem, we present a comparative review of recent theories of firm and competition that has been applied by different researchers in the High-Tech and Knowledge Intensive Organization filed. Afterwards, with a detailed review of literature and previous research papers, an initial research framework and applied research method has been proposed. The main and final section of paper assigned to describing the result of research in different steps of qualitative modeling process. The agreed concepts are related to corporate competitive capability, the elicited and analyzed experts Cause Map, the elicited collective causal maps, and the final proposed model for software industry are the modeling results for this paper.

  12. [Proposing a physiological model for Emergency Department. Operating principles, classification of overcrowding and guidelines for redesign].

    Science.gov (United States)

    Herrera Carranza, M; Aguado Correa, F; Padilla Garrido, N; López Camacho, F

    2017-04-30

    The operation of Emergency Departments (ED) is determined by demand, their own organizational structures and the connection to other medical care levels. When these elements are not simultaneous, it hinders patient flow and decreases capacity, making it necessary to employ a systemic approach to the chain of emergency care as a single operational entity. With this theoretical orientation, we suggest a conceptual model similar to the physiological cardiac output, in which the preload is the demand, the contractile or flow pump is the organizational structure, the afterload is the hospital, the pre-ED valve is primary care and outpatient emergencies, and the post-ED valve is the diagnostic support services and the specialist consultants. Based on this theoretical approach we classify the different types of ED overcrowding and systematise its causes and the different waiting lists that it generates, which can help to redesign the service and avoid its saturation.

  13. Proposed model for biomineralization of novel nanohydroxyapatite/vertically aligned multiwalled carbon nanotube scaffolds

    Directory of Open Access Journals (Sweden)

    Tayra Rodrigues Brazil

    2013-06-01

    Full Text Available For the first time, the growth mechanism of biominerals formed on plate-like nanohydroxyapatite (nHAp electrodeposited on superhydrophilic vertically aligned multi-walled carbon nanotubes (VAMWCNT-O2 is presented and a model for the specific growth preference is discussed. VAMWCNT-O2 films were obtained by microwave-assisted chemical vapor deposition method and funcionalized by oxygen plasma. nHAp/VAMWCNT-O2 nanocomposites were fabricated with a direct electrodeposition of the thin nHAp films onto the VAMWCNT-O2 films. The biomineralized "scaffolds" were obtained by soaking nHAp/VAMWCNT-O2 in simulated body fluid for 7, 14 and 21 days. Results show that the carboxyl functional groups directly attached onto VAMWCNT tips after oxygen plasma treatment were essential for the acceleration of the OH- formation and the deposition of plate-like nHAp crystals.

  14. Model's proposal in health for the indigenous towns of the Amazonian area

    International Nuclear Information System (INIS)

    Suarez Mutis, Martha Cecilia

    2001-01-01

    the author refers to the indigenous communities which should not be considered alone in the speeches, like one of the high-priority groups for the attention of the state and the society, but rather it is fundamental to think a model in health that allows to overcome the cultural barriers and the existent distrust in front of our society, as well as the contempt that they still have some sectors in the indigenous communities. The new constitutional order of Colombia conceives to the country like a nation multi-ethnic and pluri-cultural. The article 7 of the constitution promulgated in 1991 assign to the state the obligation of to recognize and to protect the ethnic diversity. The paper makes reference to the antecedents, organization of the services of health, basic plan of attention, obligatory plan of health, training and its installation in the amazons

  15. Proposed model for biomineralization of novel nanohydroxyapatite/vertically aligned multiwalled carbon nanotube scaffolds

    Energy Technology Data Exchange (ETDEWEB)

    Brazil, Tayra Rodrigues; Neves, Marcele Florencio das; Marciano, Fernanda Roberta; Lobo, Anderson Oliveira, E-mail: aolobo@univap.br [Universidade do Vale do Paraiba (UniVap), Sao Jose dos Campos, SP (Brazil). Lab. de Nanotecnologia Biomedica; Regiani, Inacio [Instituto Tecnologico de Aeronautica (ITA), Sao Jose dos Campos, SP (Brazil)

    2013-11-01

    For the first time, the growth mechanism of biominerals formed on plate-like nanohydroxyapatite (nHAp) electrodeposited on superhydrophilic vertically aligned multi-walled carbon nanotubes (VAMWCNT-O{sub 2} ) is presented and a model for the specific growth preference is discussed. VAMWCNT-O{sub 2} films were obtained by microwave-assisted chemical vapor deposition method and functionalized by oxygen plasma. nHAp/VAMWCNT-O{sub 2} nanocomposites were fabricated with a direct electrodeposition of the thin nHAp films onto the VAMWCNT-O{sub 2} films. The biomineralized 'scaffolds' were obtained by soaking nHAp/VAMWCNT-O{sub 2} in simulated body fluid for 7, 14 and 21 days. Results show that the carboxyl functional groups directly attached onto VAMWCNT tips after oxygen plasma treatment were essential for the acceleration of the OH- formation and the deposition of plate-like nHAp crystals (author)

  16. Proposed model for biomineralization of novel nanohydroxyapatite/vertically aligned multiwalled carbon nanotube scaffolds

    Energy Technology Data Exchange (ETDEWEB)

    Brazil, Tayra Rodrigues; Neves, Marcele Florencio das; Marciano, Fernanda Roberta; Lobo, Anderson Oliveira, E-mail: aolobo@univap.br [Universidade do Vale do Paraiba (UniVap), Sao Jose dos Campos, SP (Brazil). Lab. de Nanotecnologia Biomedica; Regiani, Inacio [Instituto Tecnologico de Aeronautica (ITA), Sao Jose dos Campos, SP (Brazil)

    2013-11-01

    For the first time, the growth mechanism of biominerals formed on plate-like nanohydroxyapatite (nHAp) electrodeposited on superhydrophilic vertically aligned multi-walled carbon nanotubes (VAMWCNT-O{sub 2} ) is presented and a model for the specific growth preference is discussed. VAMWCNT-O{sub 2} films were obtained by microwave-assisted chemical vapor deposition method and functionalized by oxygen plasma. nHAp/VAMWCNT-O{sub 2} nanocomposites were fabricated with a direct electrodeposition of the thin nHAp films onto the VAMWCNT-O{sub 2} films. The biomineralized 'scaffolds' were obtained by soaking nHAp/VAMWCNT-O{sub 2} in simulated body fluid for 7, 14 and 21 days. Results show that the carboxyl functional groups directly attached onto VAMWCNT tips after oxygen plasma treatment were essential for the acceleration of the OH- formation and the deposition of plate-like nHAp crystals (author)

  17. Predicting the effects of proposed Mississippi River diversions on oyster habitat quality; application of an oyster habitat suitability index model

    Science.gov (United States)

    Soniat, Thomas M.; Conzelmann, Craig P.; Byrd, Jason D.; Roszell, Dustin P.; Bridevaux, Joshua L.; Suir, Kevin J.; Colley, Susan B.

    2013-01-01

    In an attempt to decelerate the rate of coastal erosion and wetland loss, and protect human communities, the state of Louisiana developed its Comprehensive Master Plan for a Sustainable Coast. The master plan proposes a combination of restoration efforts including shoreline protection, marsh creation, sediment diversions, and ridge, barrier island, and hydrological restoration. Coastal restoration projects, particularly the large-scale diversions of fresh water from the Mississippi River, needed to supply sediment to an eroding coast potentially impact oyster populations and oyster habitat. An oyster habitat suitability index model is presented that evaluates the effects of a proposed sediment and freshwater diversion into Lower Breton Sound. Voluminous freshwater, needed to suspend and broadly distribute river sediment, will push optimal salinities for oysters seaward and beyond many of the existing reefs. Implementation and operation of the Lower Breton Sound diversion structure as proposed would render about 6,173 ha of hard bottom immediately east of the Mississippi River unsuitable for the sustained cultivation of oysters. If historical harvests are to be maintained in this region, a massive and unprecedented effort to relocate private leases and restore oyster bottoms would be required. Habitat suitability index model results indicate that the appropriate location for such efforts are to the east and north of the Mississippi River Gulf Outlet.

  18. A PROPOSAL FORECASTING MODEL FOR THE GROWTH OF THE MOBILE TELEPHONE MARKET IN BRAZIL

    Directory of Open Access Journals (Sweden)

    Luís Fernando Ascenção Guedes

    2009-10-01

    Full Text Available The element that characterizes the information era is the key role of communication and connectivity, broadly speaking, in social life. Among the ways in which users can enter voice or data networks, one of the most prominent is mobile telephony.Therefore, determining the number of mobile phones in operation in Brazil over the next few years is a relevant issue for the strategic planning of firms in this sector. Thus, this article aims to define a mathematical model suitable for calculating the number of mobile phones in operation in Brazil in forthcoming years, as a function of the behavior of the following variables during the course of time: GDP per capita, population and percentage GDP growth.To this end, a quantitative study was conducted, based on secondary data taken from preceding survey; then a linear and polynomial regression was employed to correlate GDP per capita with mobile phone density. The results showed high correlation (97.5% between phone density and Brazil’s GDP growth from 2004 to 2007. This correlation is also high in Russia, India and China.Moreover, we found that the limiting value of good correlation between GDP per capita and mobile phone density is roughly US$20,000.00 and that the limit of mobile telephony penetration is approximately 120%. Thus, taking into account several economic growth rates, we estimate that the penetration of mobile telephony will take 5 to 11 years to reach its upper limit in Brazil.Key words: Mobile telephony. Prediction model. Telecommunications.

  19. Peer review CALMET/CALPUFF dispersion modelling analysis : Proposed Duke Point generation facility Georgia Strait Crossing pipeline

    International Nuclear Information System (INIS)

    2002-01-01

    A peer review of the air quality dispersion modeling analysis for the proposed gas-fired plant at Duke Point in the vicinity of Nanaimo, British Columbia was required, and SENES Consultants Limited (SENES) was commissioned to perform it. British Columbia Hydro had requested that Levelton Engineering Ltd. prepare an air quality impact assessment, and it was submitted to be included in Vancouver Island Generation Project (VIGP) permit application. This permit application was for the Joint Panel Review of the Georgia Strait Crossing Pipeline (GSX) Project and the British Columbia Environmental Assessment Office. The CALMET/CALPUFF Modelling System had been used by Levelton to conduct the air quality dispersion modelling analysis. Copies of the input and output files that had been used for the conduct of the modelling analysis were provided to SENES. The ability for SENES to reproduce the modelling results that had been published in the GSX application represented the first step in the peer review. This was accomplished by running the files received from Levelton into the CALMET/CALPUFF models. A detailed review of the methodology selected by Levelton during the conduct of the dispersion modelling analysis was then initiated by SENES. Some deficiencies were identified by SENES, despite concurrence with the overall conceptual approach adopted by Levelton. The deficiencies concerned meteorological data; startup, partial load and upset conditions; pollutant emissions; health risk assessment; cumulative impact on ambient particulate matter 10 concentrations; and collateral environmental impacts. refs., 2 tabs., 21 figs

  20. Modeling the Hydrogeochemical Transport of Radionuclides through Engineered Barriers System in the Proposed LLW Disposal Site of Taiwan - 12082

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Wen-Sheng [Hydrotech Research Institute, National Taiwan University, Taipei, Taiwan (China); Liu, Chen-Wuing; Tsao, Jui-Hsuan [Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan (China); Li, Ming-Hsu [Institute of Hydrological and Oceanic Sciences, National Central University, Jhongli, Taiwan (China)

    2012-07-01

    A proposed site for final disposal of low-level radioactive waste located in Daren Township of Taitung County along the southeastern coast has been on the selected list in Taiwan. The geology of the Daren site consists of argillite and meta-sedimentary rocks. A mined cavern design with a tunnel system of 500 m below the surface is proposed. Concrete is used as the main confinement material for the engineered barrier. To investigate the hydrogeochemical transport of radionuclides through engineered barriers system, HYDROGEOCHEM5.0 model was applied to simulate the complex chemical interactions among radionuclides, the cement minerals of the concrete, groundwater flow, and transport in the proposed site. The simulation results showed that the engineered barriers system with the side ditch efficiently drained the ground water and lowered the concentration of the concrete degradation induced species (e.g., hydrogen ion, sulfate, and chloride). The velocity of groundwater observed at side ditch gradually decreased with time due to the fouling of pore space by the mineral formation of ettringite and thaumasite. The short half-life of Co-60, Sr-90 and Cs-137 significantly reduced the concentrations, whereas the long half-life of I-129(1.57x10{sup 7} years) and Am-241(432 years) remain stable concentrations at the interface of waste canister and concrete barrier after 300 years. The mineral saturation index (SI) was much less than zero due to the low aqueous concentration of radionuclide, so that the precipitation formation of Co-60, Sr-90, I-129, Cs-137 and Am-241 related minerals were not found. The effect of adsorption/desorption (i.e., surface complexation model) could be a crucial geochemical mechanism for the modeling of liquid-solid phase behavior of radionuclide in geochemically dynamic environments. Moreover, the development of advanced numerical models that are coupled with hydrogeochemical transport and dose assessment of radionuclide is required in the future

  1. A new proposal for laparoscopic left colectomy in a rat model

    Directory of Open Access Journals (Sweden)

    Leonardo de Castro Durães

    2013-04-01

    Full Text Available PURPOSE: To evaluate the feasibility and safety of a new technique for laparoscopic segmental colectomy and primary anastomosis in the left colon of rats. METHODS: Thirty rats were randomly assigned to three groups of ten animals each. All animals underwent segmental resection of the left colon and end-to-end anastomosis. In Group I, the animals underwent laparoscopic surgery with carbon dioxide pneumoperitoneum at a pressure of 5 mmHg. In Group II, the animals underwent pneumoperitoneum with carbon dioxide at a pressure of 12 mmHg. In Group III, the control group, the animals underwent open surgery. All animals were reopened on the 7th postoperative day and were evaluated for peritonitis, abscesses, anastomotic dehiscence and bowel obstruction, and the anastomosis bursting pressure was measured. RESULTS: No obstructions, peritonitis or abscesses were found in any of the animals. An animal in Group I exhibited a blocked anastomosis leakage. The average anastomosis bursting pressure in the 30 animals was 187.02 ± 68.35 mmHg. There was no significant difference in the anastomosis bursting pressure among the groups (p = 0.503 CONCLUSION: The laparoscopic experimental model was feasible and safe for segmental colectomy and anastomosis of the left colon in rats.

  2. Bringing Emotions into Legal Education Through the Experimental Learning Model: A Proposal

    Directory of Open Access Journals (Sweden)

    Lidia Rodak

    2017-12-01

    Full Text Available The paper calls for the integration of theory and practice in legal education through integrating emotions into learning process. The ideas it aims to put forward have their roots in the work of the American educational psychologist, David A. Kolb. Using the Experiential Learning Theory Model, he elaborated on, the paper demonstrates how it can be adapted to suit legal education and what the benefits are for legal education.Este artículo propone integrar la teoría y la práctica en la educación jurídica, a través de la integración de las emociones en el proceso de aprendizaje. La propuesta se sustenta en el pensamiento elaborado por el psicólogo de la educación norteamericano David A. Kolb. El artículo demuestra que se puede adaptar la Teoría del Modelo de Aprendizaje Experiencial que él construyó a la educación en Derecho, y las ventajas que implicaría. DOWNLOAD THIS PAPER FROM SSRN: https://ssrn.com/abstract=3075147

  3. Genetic Determinants of Cardio-Metabolic Risk: A Proposed Model for Phenotype Association and Interaction

    Science.gov (United States)

    Blackett, Piers R; Sanghera, Dharambir K

    2012-01-01

    This review provides a translational and unifying summary of metabolic syndrome genetics and highlights evidence that genetic studies are starting to unravel and untangle origins of the complex and challenging cluster of disease phenotypes. The associated genes effectively express in the brain, liver, kidney, arterial endothelium, adipocytes, myocytes and β cells. Progression of syndrome traits has been associated with ectopic lipid accumulation in the arterial wall, visceral adipocytes, myocytes, and liver. Thus it follows that the genetics of dyslipidemia, obesity, and non-alcoholic fatty liver (NAFLD) disease are central in triggering progression of the syndrome to overt expression of disease traits, and have become a key focus of interest for early detection and for designing prevention and treatments. To support the “birds’ eye view” approach we provide a road-map depicting commonality and interrelationships between the traits and their genetic and environmental determinants based on known risk factors, metabolic pathways, pharmacological targets, treatment responses, gene networks, pleiotropy, and association with circadian rhythm. Although only a small portion of the known heritability is accounted for and there is insufficient support for clinical application of gene-based prediction models, there is direction and encouraging progress in a rapidly moving field that is beginning to show clinical relevance. PMID:23351585

  4. Genetic determinants of cardiometabolic risk: a proposed model for phenotype association and interaction.

    Science.gov (United States)

    Blackett, Piers R; Sanghera, Dharambir K

    2013-01-01

    This review provides a translational and unifying summary of metabolic syndrome genetics and highlights evidence that genetic studies are starting to unravel and untangle origins of the complex and challenging cluster of disease phenotypes. The associated genes effectively express in the brain, liver, kidney, arterial endothelium, adipocytes, myocytes, and β cells. Progression of syndrome traits has been associated with ectopic lipid accumulation in the arterial wall, visceral adipocytes, myocytes, and liver. Thus, it follows that the genetics of dyslipidemia, obesity, and nonalcoholic fatty liver disease are central in triggering progression of the syndrome to overt expression of disease traits and have become a key focus of interest for early detection and for designing prevention and treatments. To support the "birds' eye view" approach, we provide a road-map depicting commonality and interrelationships between the traits and their genetic and environmental determinants based on known risk factors, metabolic pathways, pharmacologic targets, treatment responses, gene networks, pleiotropy, and association with circadian rhythm. Although only a small portion of the known heritability is accounted for and there is insufficient support for clinical application of gene-based prediction models, there is direction and encouraging progress in a rapidly moving field that is beginning to show clinical relevance. Copyright © 2013 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  5. Genetics of borderline personality disorder: systematic review and proposal of an integrative model.

    Science.gov (United States)

    Amad, Ali; Ramoz, Nicolas; Thomas, Pierre; Jardri, Renaud; Gorwood, Philip

    2014-03-01

    Borderline personality disorder (BPD) is one of the most common mental disorders and is characterized by a pervasive pattern of emotional lability, impulsivity, interpersonal difficulties, identity disturbances, and disturbed cognition. Here, we performed a systematic review of the literature concerning the genetics of BPD, including familial and twin studies, association studies, and gene-environment interaction studies. Moreover, meta-analyses were performed when at least two case-control studies testing the same polymorphism were available. For each gene variant, a pooled odds ratio (OR) was calculated using fixed or random effects models. Familial and twin studies largely support the potential role of a genetic vulnerability at the root of BPD, with an estimated heritability of approximately 40%. Moreover, there is evidence for both gene-environment interactions and correlations. However, association studies for BPD are sparse, making it difficult to draw clear conclusions. According to our meta-analysis, no significant associations were found for the serotonin transporter gene, the tryptophan hydroxylase 1 gene, or the serotonin 1B receptor gene. We hypothesize that such a discrepancy (negative association studies but high heritability of the disorder) could be understandable through a paradigm shift, in which "plasticity" genes (rather than "vulnerability" genes) would be involved. Such a framework postulates a balance between positive and negative events, which interact with plasticity genes in the genesis of BPD. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Functional and structural changes of human erythrocyte catalase induced by cimetidine: proposed model of binding.

    Science.gov (United States)

    Yazdi, Fatemeh; Minai-Tehrani, Dariush; Jahngirvand, Mahboubeh; Almasirad, Ali; Mousavi, Zahra; Masoud, Masoudeh; Mollasalehi, Hamidreza

    2015-06-01

    In erythrocyte, catalase plays an important role to protect cells from hydrogen peroxide toxicity. Hydrogen peroxide is a byproduct compound which is produced during metabolic pathway of cells. Cimetidine, a histamine H2 receptor antagonist, is used for gastrointestinal tract diseases and prevents the extra release of gastric acid. In this study, the effect of cimetidine on the activity of human erythrocyte catalase was investigated. Erythrocytes were broken by hypotonic solution. The supernatant was used for catalase assay and kinetics study. Lineweaver-Burk plot was performed to determine the type of inhibition. The kinetics data revealed that cimetidine inhibited the catalase activity by mixed inhibition. The IC50 (1.54 μM) and Ki (0.45 μM) values of cimetidine determined that the drug was bound to the enzyme with high affinity. Circular dichroism and fluorescence measurement showed that the binding of cimetidine to the enzyme affected the content of secondary structure of the enzyme as well as its conformational changes. Docking studies were carried out to detect the site in which the drug was bound to the enzyme. Molecular modeling and energy calculation of the binding showed that the cyanoguanidine group of the drug connected to Asp59 via two hydrogen bonds, while the imidazole group of the drug interacted with Phe64 in the enzyme by a hydrophobic interaction. In conclusion, cimetidine could bind to human erythrocyte catalase, and its interaction caused functional and conformational changes in the enzyme.

  7. Alpins and thibos vectorial astigmatism analyses: proposal of a linear regression model between methods

    Directory of Open Access Journals (Sweden)

    Giuliano de Oliveira Freitas

    2013-10-01

    Full Text Available PURPOSE: To determine linear regression models between Alpins descriptive indices and Thibos astigmatic power vectors (APV, assessing the validity and strength of such correlations. METHODS: This case series prospectively assessed 62 eyes of 31 consecutive cataract patients with preoperative corneal astigmatism between 0.75 and 2.50 diopters in both eyes. Patients were randomly assorted among two phacoemulsification groups: one assigned to receive AcrySof®Toric intraocular lens (IOL in both eyes and another assigned to have AcrySof Natural IOL associated with limbal relaxing incisions, also in both eyes. All patients were reevaluated postoperatively at 6 months, when refractive astigmatism analysis was performed using both Alpins and Thibos methods. The ratio between Thibos postoperative APV and preoperative APV (APVratio and its linear regression to Alpins percentage of success of astigmatic surgery, percentage of astigmatism corrected and percentage of astigmatism reduction at the intended axis were assessed. RESULTS: Significant negative correlation between the ratio of post- and preoperative Thibos APVratio and Alpins percentage of success (%Success was found (Spearman's ρ=-0.93; linear regression is given by the following equation: %Success = (-APVratio + 1.00x100. CONCLUSION: The linear regression we found between APVratio and %Success permits a validated mathematical inference concerning the overall success of astigmatic surgery.

  8. Estimating shaking-induced casualties and building damage for global earthquake events: a proposed modelling approach

    Science.gov (United States)

    So, Emily; Spence, Robin

    2013-01-01

    Recent earthquakes such as the Haiti earthquake of 12 January 2010 and the Qinghai earthquake on 14 April 2010 have highlighted the importance of rapid estimation of casualties after the event for humanitarian response. Both of these events resulted in surprisingly high death tolls, casualties and survivors made homeless. In the Mw = 7.0 Haiti earthquake, over 200,000 people perished with more than 300,000 reported injuries and 2 million made homeless. The Mw = 6.9 earthquake in Qinghai resulted in over 2,000 deaths with a further 11,000 people with serious or moderate injuries and 100,000 people have been left homeless in this mountainous region of China. In such events relief efforts can be significantly benefitted by the availability of rapid estimation and mapping of expected casualties. This paper contributes to ongoing global efforts to estimate probable earthquake casualties very rapidly after an earthquake has taken place. The analysis uses the assembled empirical damage and casualty data in the Cambridge Earthquake Impacts Database (CEQID) and explores data by event and across events to test the relationships of building and fatality distributions to the main explanatory variables of building type, building damage level and earthquake intensity. The prototype global casualty estimation model described here uses a semi-empirical approach that estimates damage rates for different classes of buildings present in the local building stock, and then relates fatality rates to the damage rates of each class of buildings. This approach accounts for the effect of the very different types of buildings (by climatic zone, urban or rural location, culture, income level etc), on casualties. The resulting casualty parameters were tested against the overall casualty data from several historical earthquakes in CEQID; a reasonable fit was found.

  9. Proposal of a Holistic Model to Support Local-Level Evidence-Based Practice

    Directory of Open Access Journals (Sweden)

    Said Shahtahmasebi

    2010-01-01

    Full Text Available In response to a central drive for evidence-based practice, there have been many research support schemes, setups, and other practices concentrating on facilitating access to external research, such as the Centre for Evidence Based Healthcare Aotearoa, the Cochrane Collaboration, and the York Centre for Reviews and Dissemination. Very little attention has been paid to supporting internal research in terms of local evidence and internal research capabilities. The whole evidence-based practice movement has alienated internal decision makers and, thus, very little progress has been made in the context of evidence informing local policy formation. Health and social policies are made centrally based on dubious claims and often evidence is sought after implementation. For example, on record, most health care practitioners appear to agree with the causal link between depression and mental illness (sometimes qualified with other social factors with suicide; off the record, even some psychiatrists doubt that such a link is applicable to the population as a whole. Therefore, be it through misplaced loyalty or a lack of support for internal researchers/decision makers, local evidence informing local decision making may have been ignored in favour of external evidence. In this paper, we present a practical holistic model to support local evidence-based decision making. This approach is more relevant in light of a new approach to primary health care of “local knowledge” complementing external evidence. One possible outcome would be to network with other regional programmes around the world to share information and identify “best” practices, such as the “Stop Youth Suicide Campaign”(www.stopyouthsuicide.com.

  10. HIV Cell-to-Cell Spread Results in Earlier Onset of Viral Gene Expression by Multiple Infections per Cell.

    Directory of Open Access Journals (Sweden)

    Mikaël Boullé

    2016-11-01

    Full Text Available Cell-to-cell spread of HIV, a directed mode of viral transmission, has been observed to be more rapid than cell-free infection. However, a mechanism for earlier onset of viral gene expression in cell-to-cell spread was previously uncharacterized. Here we used time-lapse microscopy combined with automated image analysis to quantify the timing of the onset of HIV gene expression in a fluorescent reporter cell line, as well as single cell staining for infection over time in primary cells. We compared cell-to-cell spread of HIV to cell-free infection, and limited both types of transmission to a two-hour window to minimize differences due to virus transit time to the cell. The mean time to detectable onset of viral gene expression in cell-to-cell spread was accelerated by 19% in the reporter cell line and by 35% in peripheral blood mononuclear cells relative to cell-free HIV infection. Neither factors secreted by infected cells, nor contact with infected cells in the absence of transmission, detectably changed onset. We recapitulated the earlier onset by infecting with multiple cell-free viruses per cell. Surprisingly, the acceleration in onset of viral gene expression was not explained by cooperativity between infecting virions. Instead, more rapid onset was consistent with a model where the fastest expressing virus out of the infecting virus pool sets the time for infection independently of the other co-infecting viruses.

  11. Proposing a Model to present Factors which Affect e-SCM Risk and their Impacts on Organizational Performance

    Directory of Open Access Journals (Sweden)

    ali rajabzadeh ghatari

    2010-03-01

    Full Text Available Companies strive to improve market share, grow corporate profit, and gain strategic advantage. In order to achieve these goals, supply chain competency must be placed at the heart of a company’s business model. Using e-Commerce and information and communication technologies (ICT in today’s changing demands of business has made organizations more responsive and flexible. E-Commerce and Internet have changed the nature of supply chains and re-defined how customers obtain wisdom of products, services, selection, purchasing and using them. Advent of ICT and new business environment has caused emerge of electronic supply chains. This research has proposed a model for presenting factors which affect electronic supply chain’s risk; besides the influence of the risk on financial and non-financial organization’s performance indicators. Studying the influence of the risk on organization’s performance is conducted in a sample of electronic and telecommunication companies. In order to measure these relationships, using correlation and structural equation modeling (SEM techniques proposed that electronic supply chain risk identification and management have significant impact on organization’s performance improvement.

  12. Self-rated health, multimorbidity and depression in Mexican older adults: Proposal and evaluation of a simple conceptual model.

    Science.gov (United States)

    Bustos-Vázquez, Eduardo; Fernández-Niño, Julián Alfredo; Astudillo-Garcia, Claudia Iveth

    2017-04-01

    Self-rated health is an individual and subjective conceptualization involving the intersection of biological, social and psychological factors. It provides an invaluable and unique evaluation of a person's general health status. To propose and evaluate a simple conceptual model to understand self-rated health and its relationship to multimorbidity, disability and depressive symptoms in Mexican older adults. We conducted a cross-sectional study based on a national representative sample of 8,874 adults of 60 years of age and older. Self-perception of a positive health status was determined according to a Likert-type scale based on the question: "What do you think is your current health status?" Intermediate variables included multimorbidity, disability and depressive symptoms, as well as dichotomous exogenous variables (sex, having a partner, participation in decision-making and poverty). The proposed conceptual model was validated using a general structural equation model with a logit link function for positive self-rated health. A direct association was found between multimorbidity and positive self-rated health (OR=0.48; 95% CI: 0.42-0.55), disability and positive self-rated health (OR=0.35; 95% CI: 0.30-0.40), depressive symptoms and positive self-rated health (OR=0.38; 95% CI: 0.34-0.43). The model also validated indirect associations between disability and depressive symptoms (OR=2.25; 95% CI: 2.01- 2.52), multimorbidity and depressive symptoms (OR=1.79; 95% CI: 1.61-2.00) and multimorbidity and disability (OR=1.98; 95% CI: 1.78-2.20). A parsimonious theoretical model was empirically evaluated, which enabled identifying direct and indirect associations with positive self-rated health.

  13. Integrated model of biopurification system for home sewage. A proposal for peri-urban communities from south center of Chile

    International Nuclear Information System (INIS)

    Parra Pierart, Izaul; Chiang Rojas, Gustavo

    2013-01-01

    The rapid growth of world population and its impacts has led to search new sources of water supply. Wastewater constitutes an additional source to satisfy the demand of this resource. Diverse researchers have designed alternatives for improve its processing and promote its utilization. This study examines some alternatives of bio-purification and proposes a conceptual design of a hybrid system that combines the use of a bio filter with artificial wetlands. The model designed contributes to improve water resources management and has educational, landscape and environmental benefits for peri-urban communities. Besides constitutes an alternative to promote more efficiently natural resources management at the local level.

  14. Earlier Pulmonary Valve Replacement in Down Syndrome Patients Following Tetralogy of Fallot Repair.

    Science.gov (United States)

    Sullivan, Rachel T; Frommelt, Peter C; Hill, Garick D

    2017-08-01

    The association between Down syndrome and pulmonary hypertension could contribute to more severe pulmonary regurgitation after tetralogy of Fallot repair and possibly earlier pulmonary valve replacement. We compared cardiac magnetic resonance measures of pulmonary regurgitation and right ventricular dilation as well as timing of pulmonary valve replacement between those with and without Down syndrome after tetralogy of Fallot repair. Review of our surgical database from 2000 to 2015 identified patients with tetralogy of Fallot with pulmonary stenosis. Those with Down syndrome were compared to those without. The primary outcome of interest was time from repair to pulmonary valve replacement. Secondary outcomes included pulmonary regurgitation and indexed right ventricular volume on cardiac magnetic resonance imaging. The cohort of 284 patients included 35 (12%) with Down syndrome. Transannular patch repair was performed in 210 (74%). Down syndrome showed greater degree of pulmonary regurgitation (55 ± 14 vs. 37 ± 16%, p = 0.01) without a significantly greater rate of right ventricular dilation (p = 0.09). In multivariable analysis, Down syndrome (HR 2.3, 95% CI 1.2-4.5, p = 0.02) and transannular patch repair (HR 5.5, 95% CI 1.7-17.6, p = 0.004) were significant risk factors for valve replacement. Those with Down syndrome had significantly lower freedom from valve replacement (p = 0.03). Down syndrome is associated with an increased degree of pulmonary regurgitation and earlier pulmonary valve replacement after tetralogy of Fallot repair. These patients require earlier assessment by cardiac magnetic resonance imaging to determine timing of pulmonary valve replacement and evaluation for and treatment of preventable causes of pulmonary hypertension.

  15. Insight Into Illness and Cognition in Schizophrenia in Earlier and Later Life.

    Science.gov (United States)

    Gerretsen, Philip; Voineskos, Aristotle N; Graff-Guerrero, Ariel; Menon, Mahesh; Pollock, Bruce G; Mamo, David C; Mulsant, Benoit H; Rajji, Tarek K

    2017-04-01

    Impaired insight into illness in schizophrenia is associated with illness severity and deficits in premorbid intellectual function, executive function, and memory. A previous study of patients aged 60 years and older found that illness severity and premorbid intellectual function accounted for variance in insight impairment. As such, we aimed to test whether similar relationships would be observed in earlier life. A retrospective analysis was performed on 1 large sample of participants (n = 171) with a DSM-IV-TR diagnosis of schizophrenia aged 19 to 79 years acquired from 2 studies: (1) a psychosocial intervention trial for older persons with schizophrenia (June 2008 to May 2014) and (2) a diffusion tensor imaging and genetics study of psychosis across the life span (February 2007 to December 2013). We assessed insight into illness using the Positive and Negative Syndrome Scale (PANSS) item G12 and explored its relationship to illness severity (PANSS total modified), premorbid intellectual function (Wechsler Test of Adult Reading [WTAR]), and cognition. Insight impairment was more severe in later life (≥ 60 years) than in earlier years (t = -3.75, P insight was explained by PANSS total modified (Exp[B] = 1.070, P insight, they did not independently contribute to its variance. However, the relationships between impaired insight and illness severity and between impaired insight and cognition, particularly working memory, were stronger in later life than in earlier life. These results suggest an opportunity for intervention may exist with cognitive-enhancing neurostimulation or medications to improve insight into illness in schizophrenia across the life span. Original study registered on ClinicalTrials.gov (identifier: NCT00832845). © Copyright 2017 Physicians Postgraduate Press, Inc.

  16. Assumption and program of the earlier stage construction of L/ILW disposal site

    International Nuclear Information System (INIS)

    Li Xuequn; Chen Shi; Li Xinbang

    1993-01-01

    The authors analysed the production and treatment of low- and intermediate-level radwastes (L/ILW) in China. Some problems and situation in this field are introduced. Over the past ten years, preliminary efforts have been made by CNNC (China National Nuclear Corporation) in policy, law and rules, developing program, management system, siting, engineering techniques, and safety assessment for radwaste disposal. The investment of the earlier stage work of L/ILW disposal site construction is estimated, the program and assumption to disposal site construction of the L/ILW are reviewed

  17. Earlier nesting by generalist predatory bird is associated with human responses to climate change.

    Science.gov (United States)

    Smith, Shawn H; Steenhof, Karen; McClure, Christopher J W; Heath, Julie A

    2017-01-01

    Warming temperatures cause temporal changes in growing seasons and prey abundance that drive earlier breeding by birds, especially dietary specialists within homogeneous habitat. Less is known about how generalists respond to climate-associated shifts in growing seasons or prey phenology, which may occur at different rates across land cover types. We studied whether breeding phenology of a generalist predator, the American kestrel (Falco sparverius), was associated with shifts in growing seasons and, presumably, prey abundance, in a mosaic of non-irrigated shrub/grasslands and irrigated crops/pastures. We examined the relationship between remotely-sensed normalized difference vegetation index (NDVI) and abundance of small mammals that, with insects, constitute approximately 93% of kestrel diet biomass. We used NDVI to estimate the start of the growing season (SoGS) in irrigated and non-irrigated lands from 1992 to 2015 and tested whether either estimate of annual SoGS predicted the timing of kestrel nesting. Finally, we examined relationships among irrigated SoGS, weather and crop planting. NDVI was a useful proxy for kestrel prey because it predicted small mammal abundance and past studies showed that NDVI predicts insect abundance. NDVI-estimated SoGS advanced significantly in irrigated lands (β = -1·09 ± 0·30 SE) but not in non-irrigated lands (β = -0·57 ± 0·53). Average date of kestrel nesting advanced 15 days in the past 24 years and was positively associated with the SoGS in irrigated lands, but not the SoGS in non-irrigated lands. Advanced SoGS in irrigated lands was related to earlier planting of crops after relatively warm winters, which were more common in recent years. Despite different patterns of SoGS change between land cover types, kestrel nesting phenology shifted with earlier prey availability in irrigated lands. Kestrels may preferentially track prey in irrigated lands over non-irrigated lands because of higher quality prey on

  18. Proposing a New Approach for Supplier Selection Based on Kraljic’s Model Using FMEA and Integer Linear Programming

    Directory of Open Access Journals (Sweden)

    S. Mohammad Arabzad

    2012-06-01

    Full Text Available In recent years, numerous methods have been proposed to deal with supplier evaluation and selection problem, but a point which has been usually neglected by researchers is the role of purchasing items. The aim of this paper is to propose an integrated approach to select suppliers and allocate orders on the basis of the nature of the purchasing items which means that this issue plays an important role in supplier selection and order allocation. Therefore, items are first categorized according to the Kraljic’s model by the use of FMEA technique. Then, suppliers are categorized and evaluated in four phases with respect to different types of purchasing items (Strategic, Bottleneck, Leverage and Routine. Finally, an integer linear programming is utilized to allocate purchasing orders to suppliers. Furthermore, an empirical example is conducted to illustrate the stage of proposed approach. Results imply that ranking of suppliers and allocation of purchasing items based on the nature of purchasing items will create more capabilities in managing purchasing items and suppliers .

  19. The Role of Interpersonal Relations in Healthcare Team Communication and Patient Safety: A Proposed Model of Interpersonal Process in Teamwork.

    Science.gov (United States)

    Lee, Charlotte Tsz-Sum; Doran, Diane Marie

    2017-06-01

    Patient safety is compromised by medical errors and adverse events related to miscommunications among healthcare providers. Communication among healthcare providers is affected by human factors, such as interpersonal relations. Yet, discussions of interpersonal relations and communication are lacking in healthcare team literature. This paper proposes a theoretical framework that explains how interpersonal relations among healthcare team members affect communication and team performance, such as patient safety. We synthesized studies from health and social science disciplines to construct a theoretical framework that explicates the links among these constructs. From our synthesis, we identified two relevant theories: framework on interpersonal processes based on social relation model and the theory of relational coordination. The former involves three steps: perception, evaluation, and feedback; and the latter captures relational communicative behavior. We propose that manifestations of provider relations are embedded in the third step of the framework on interpersonal processes: feedback. Thus, varying team-member relationships lead to varying collaborative behavior, which affects patient-safety outcomes via a change in team communication. The proposed framework offers new perspectives for understanding how workplace relations affect healthcare team performance. The framework can be used by nurses, administrators, and educators to improve patient safety, team communication, or to resolve conflicts.

  20. Sports Management for Sports Massification Planned and Executed by Social Organizations. Critics to Models, Experiences and Proposal Methodological Accompaniment

    Directory of Open Access Journals (Sweden)

    Lorenza Antonia Reyes de Duran

    2016-08-01

    Full Text Available The proposal analysis, interpretation, disassembly, self-criticism and guidance is born and comes from work experience planned mass sports and social organizations opposed-not in the conventional sense comparative-private business models and sport, state and management. The contribution made by the sports management experience from positions of power, either state or business are undeniable and its impact is difficult to express in numbers for its humanistic value, which is incalculable. However, it is urgent to emphasize the products and results achieved by some social organizations related to sport; as are the reference cases in Higuerón and the municipality Independence of Yaracuy state. From a dialectical analysis of reality, we try to understand the complex system that involves high-level sports management and performance, we introduce in the praxical notions of sporting activity and associated approach applied to social and community work. As opening and closing action research processes, we will make a proposal to accompany sports management concerning overcrowding by and from social organizations. This proposal is constructed from an innovative, flexible, open, inclusive and social, community and organizational curriculum relevance.

  1. Feasibility analysis in the expansion proposal of the nuclear power plant Laguna Verde: application of real options, binomial model

    International Nuclear Information System (INIS)

    Hernandez I, S.; Ortiz C, E.; Chavez M, C.

    2011-11-01

    At the present time, is an unquestionable fact that the nuclear electrical energy is a topic of vital importance, no more because eliminates the dependence of the hydrocarbons and is friendly with the environment, but because is also a sure and reliable energy source, and represents a viable alternative before the claims in the growing demand of electricity in Mexico. Before this panorama, was intended several scenarios to elevate the capacity of electric generation of nuclear origin with a variable participation. One of the contemplated scenarios is represented by the expansion project of the nuclear power plant Laguna Verde through the addition of a third reactor that serves as detonator of an integral program that proposes the installation of more nuclear reactors in the country. Before this possible scenario, the Federal Commission of Electricity like responsible organism of supplying energy to the population should have tools that offer it the flexibility to be adapted to the possible changes that will be presented along the project and also gives a value to the risk to future. The methodology denominated Real Options, Binomial model was proposed as an evaluation tool that allows to quantify the value of the expansion proposal, demonstrating the feasibility of the project through a periodic visualization of their evolution, all with the objective of supplying a financial analysis that serves as base and justification before the evident apogee of the nuclear energy that will be presented in future years. (Author)

  2. Full Field and Anomaly Initialisation using a low order climate model: a comparison, and proposals for advanced formulations

    Science.gov (United States)

    Weber, Robin; Carrassi, Alberto; Guemas, Virginie; Doblas-Reyes, Francisco; Volpi, Danila

    2014-05-01

    Full Field (FFI) and Anomaly Initialisation (AI) are two schemes used to initialise seasonal-to-decadal (s2d) prediction. FFI initialises the model on the best estimate of the actual climate state and minimises the initial error. However, due to inevitable model deficiencies, the trajectories drift away from the observations towards the model's own attractor, inducing a bias in the forecast. AI has been devised to tackle the impact of drift through the addition of this bias onto the observations, in the hope of gaining an initial state closer to the model attractor. Its goal is to forecast climate anomalies. The large variety of experimental setups, global coupled models, and observational networks adopted world-wide have led to varying results with regards to the relative performance of AI and FFI. Our research is firstly motivated in a comparison of these two initialisation approaches under varying circumstances of observational errors, observational distributions, and model errors. We also propose and compare two advanced schemes for s2d prediction. Least Square Initialisation (LSI) intends to propagate observational information of partially initialized systems to the whole model domain, based on standard practices in data assimilation and using the covariance of the model anomalies. Exploring the Parameters Uncertainty (EPU) is an online drift correction technique applied during the forecast run after initialisation. It is designed to estimate, and subtract, the bias in the forecast related to parametric error. Experiments are carried out using an idealized coupled dynamics in order to facilitate better control and robust statistical inference. Results show that an improvement of FFI will necessitate refinements in the observations, whereas improvements in AI are subject to model advances. A successful approximation of the model attractor using AI is guaranteed only when the differences between model and nature probability distribution functions (PDFs) are

  3. Evaluation of the existing triple point path models with new experimental data: proposal of an original empirical formulation

    Science.gov (United States)

    Boutillier, J.; Ehrhardt, L.; De Mezzo, S.; Deck, C.; Magnan, P.; Naz, P.; Willinger, R.

    2018-03-01

    With the increasing use of improvised explosive devices (IEDs), the need for better mitigation, either for building integrity or for personal security, increases in importance. Before focusing on the interaction of the shock wave with a target and the potential associated damage, knowledge must be acquired regarding the nature of the blast threat, i.e., the pressure-time history. This requirement motivates gaining further insight into the triple point (TP) path, in order to know precisely which regime the target will encounter (simple reflection or Mach reflection). Within this context, the purpose of this study is to evaluate three existing TP path empirical models, which in turn are used in other empirical models for the determination of the pressure profile. These three TP models are the empirical function of Kinney, the Unified Facilities Criteria (UFC) curves, and the model of the Natural Resources Defense Council (NRDC). As discrepancies are observed between these models, new experimental data were obtained to test their reliability and a new promising formulation is proposed for scaled heights of burst ranging from 24.6-172.9 cm/kg^{1/3}.

  4. Proposal for a model to assess the effect of seismic activity on the triggering of debris flows

    Science.gov (United States)

    Vidar Vangelsten, Bjørn; Liu, Zhongqiang; Eidsvig, Unni; Luna, Byron Quan; Nadim, Farrokh

    2013-04-01

    Landslide triggered by earthquakes is a serious threat for many communities around the world, and in some cases is known to have caused 25-50% of the earthquake fatalities. Seismic shaking can contribute to the triggering of debris flows either during the seismic event or indirectly by increasing the susceptibility of the slope to debris flow during intense rainfall in a period after the seismic event. The paper proposes a model to quantify both these effects. The model is based on an infinite slope formulation where precipitation and earthquakes influence the slope stability as follows: (1) During the shaking, the factor of safety is reduced due to cyclic pore pressure build-up where the cyclic pore pressure is modelled as a function of earthquake duration and intensity (measured as number of equivalent shear stress cycles and cyclic shear stress magnitude) and in-situ soil conditions (measured as average normalised shear stress). The model is calibrated using cyclic triaxial and direct simple shear (DSS) test data on clay and sand. (2) After the shaking, the factor of safety is modified using a combined empirical and analytical model that links observed earthquake induced changes in rainfall thresholds for triggering of debris flow to an equivalent reduction in soil shear strength. The empirical part uses data from past earthquakes to propose a conceptual model linking a site-specific reduction factor for rainfall intensity threshold (needed to trigger debris flows) to earthquake magnitude, distance from the epicentre and time period after the earthquake. The analytical part is a hydrological model for transient rainfall infiltration into an infinite slope in order to translate the change in rainfall intensity threshold into an equivalent reduction in soil shear strength. This is generalised into a functional form giving a site-specific shear strength reduction factor as function of earthquake history and soil conditions. The model is suitable for hazard and risk

  5. The green electricity market model. Proposal for an optional, cost-neutral direct marketing model for supplying electricity customers

    International Nuclear Information System (INIS)

    Heinemann, Ronald

    2014-01-01

    One of the main goals of the Renewable Energy Law (EEG) is the market integration of renewable energy resources. For this purpose it has introduced compulsory direct marketing on the basis of a moving market premium. At the same time the green electricity privilege, a regulation which made it possible for customers to be supplied with electricity from EEG plants, has been abolished without substitution with effect from 1 August 2014. This means that, aside from other direct marketing channels, which will not be economically viable save for in a few exceptional cases, it will no longer be possible in future to sell electricity from EEG plants to electricity customers under the designation ''electricity from renewable energy''. The reason for this is that electricity sold under the market premium model can no longer justifiably be said to originate from renewable energy. As a consequence, almost all green electricity products sold in Germany carry a foreign green electricity certificate.

  6. Skin-to-skin contact is associated with earlier breastfeeding attainment in preterm infants.

    Science.gov (United States)

    Oras, Paola; Thernström Blomqvist, Ylva; Hedberg Nyqvist, Kerstin; Gradin, Maria; Rubertsson, Christine; Hellström-Westas, Lena; Funkquist, Eva-Lotta

    2016-07-01

    This study investigated the effects of skin-to-skin contact on breastfeeding attainment, duration and infant growth in preterm infants, as this has not been sufficiently explored. A prospective longitudinal study on Kangaroo mother care was carried out, comprising 104 infants with a gestational age of 28 + 0 to 33 + 6 and followed up to one year of corrected age. Parents and staff recorded the duration of skin-to skin contact during the stay in the neonatal intensive care unit (NICU). Medical data were collected through patient records, and follow-up questionnaires were filled in by parents. The 53 infants who attained full breastfeeding in the NICU did so at a median (range) of 35 + 0 (32 + 1 to 37 + 5) weeks of postmenstrual age, and skin-to-skin contact was the only factor that influenced earlier attainment in the regression analysis (R(2) 0.215 p skin-to-skin contact during the stay in the NICU did not affect the duration of breastfeeding or infant growth after discharge. Furthermore, infant growth was not affected by the feeding strategy of exclusive, partial breastfeeding or no breastfeeding. A longer daily duration of skin-to-skin contact in the NICU was associated with earlier attainment of exclusive breastfeeding. ©2016 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  7. The semiquantitative three-phase bone scintigraphy on hemiplegic patients with earlier complex regional pain syndrome

    International Nuclear Information System (INIS)

    Li Fang; Liu Xingdang; Lu Zhihui; Liu Congjin

    2010-01-01

    Objective: To investigate the difference between the early phases and delay phase of three-phase bone scintigraphy on hemiplegic patients with earlier complex regional pain syndrome (CRPS). Methods: Twenty-nine stroke patients with hemiplegia complicating CRPS received three-phase bone scintigraphy after intravenous injection of 99 Tc m -methylene diphosphonate (MDP). The region of interest (ROI) technique was used to obtain the radioactive counts of involved joints and contralateral sites on wrists, metacarpophalangeal, proximal interphalangeal and distal interphalangeal joints. The total counts of these four sites in each patient were then obtained and the total uptake ratios of involved joints/contralateral joints for each phase were calculated to compare the difference among the three phases. Wilcoxon test and ANOVA were used in data analyses. Results: The involved joints of hemiplegic side displayed higher tracer uptake. There were significant differences of the radioactive counts between involved joints and uninvolved ones in the perfusion, pool and delay phase (Wilcoxon test, Z: -4.73 to -2.10, P<0.05). There was no significant difference of total uptake ratios of involved joints/contralateral joints among the three phases (ANOVA, F = 0. 807, P < 0.05). Conclusions: Due to higher bone seeking agent accumulation on three-phase bone scintigraphy, both early phases and delay phase imaging showed similar value in stroke patients with hemiplegia complicating earlier CRPS. (authors)

  8. Earlier adolescent substance use onset predicts stronger connectivity between reward and cognitive control brain networks.

    Science.gov (United States)

    Weissman, David G; Schriber, Roberta A; Fassbender, Catherine; Atherton, Olivia; Krafft, Cynthia; Robins, Richard W; Hastings, Paul D; Guyer, Amanda E

    2015-12-01

    Early adolescent onset of substance use is a robust predictor of future substance use disorders. We examined the relation between age of substance use initiation and resting state functional connectivity (RSFC) of the core reward processing (nucleus accumbens; NAcc) to cognitive control (prefrontal cortex; PFC) brain networks. Adolescents in a longitudinal study of Mexican-origin youth reported their substance use annually from ages 10 to 16 years. At age 16, 69 adolescents participated in a resting state functional magnetic resonance imaging scan. Seed-based correlational analyses were conducted using regions of interest in bilateral NAcc. The earlier that adolescents initiated substance use, the stronger the connectivity between bilateral NAcc and right dorsolateral PFC, right dorsomedial PFC, right pre-supplementary motor area, right inferior parietal lobule, and left medial temporal gyrus. The regions that demonstrated significant positive linear relationships between the number of adolescent years using substances and connectivity with NAcc are nodes in the right frontoparietal network, which is central to cognitive control. The coupling of reward and cognitive control networks may be a mechanism through which earlier onset of substance use is related to brain function over time, a trajectory that may be implicated in subsequent substance use disorders. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  9. Light pollution is associated with earlier tree budburst across the United Kingdom.

    Science.gov (United States)

    Ffrench-Constant, Richard H; Somers-Yeates, Robin; Bennie, Jonathan; Economou, Theodoros; Hodgson, David; Spalding, Adrian; McGregor, Peter K

    2016-06-29

    The ecological impact of night-time lighting is of concern because of its well-demonstrated effects on animal behaviour. However, the potential of light pollution to change plant phenology and its corresponding knock-on effects on associated herbivores are less clear. Here, we test if artificial lighting can advance the timing of budburst in trees. We took a UK-wide 13 year dataset of spatially referenced budburst data from four deciduous tree species and matched it with both satellite imagery of night-time lighting and average spring temperature. We find that budburst occurs up to 7.5 days earlier in brighter areas, with the relationship being more pronounced for later-budding species. Excluding large urban areas from the analysis showed an even more pronounced advance of budburst, confirming that the urban 'heat-island' effect is not the sole cause of earlier urban budburst. Similarly, the advance in budburst across all sites is too large to be explained by increases in temperature alone. This dramatic advance of budburst illustrates the need for further experimental investigation into the impact of artificial night-time lighting on plant phenology and subsequent species interactions. As light pollution is a growing global phenomenon, the findings of this study are likely to be applicable to a wide range of species interactions across the world. © 2016 The Authors.

  10. PROPOSAL FOR A MEASUREMENT MODEL FOR SOFTWARE TESTS WITH A FOCUS ON THE MANAGEMENT OF OUTSOURCED SERVICES

    Directory of Open Access Journals (Sweden)

    Angelica Toffano Seidel Calazans

    2012-08-01

    Full Text Available The need for outsourcing IT services has shown a significant growth over the past few years. This article presents a proposal for a measurement model for Software Tests with a focus on the management of these outsourced services by governmental organizations. The following specific goals were defined: to identify and analyze the test process; to identify and analyze the existing standards that govern the hiring of IT services and to propose a Measurement Model for outsourced services of this type. As to the analysis of the data collected (documentary research and semi-structured interviews, content analysis was adopted, and in order to prepare the metrics, the GQM – Goal, Questions, Metrics – approach was used. The result was confirmed by semi-structured interviews. Here is what the research identifies as possible: to establish objective and measurable criteria for a measurement size as the input to evaluate the efforts and deadlines involved; to follow up the test sub-processes and to evaluate the service quality. Therefore, the management of this type of service hiring can be done more efficiently.

  11. Proposed heat transfer model for the gas-liquid heat transfer effects observed in the Stanford Research Institute scaled tests

    International Nuclear Information System (INIS)

    Corradini, M.; Sonin, A.A.; Todreas, N.

    1976-12-01

    In 1971-72, the Stanford Research Institute conducted a series of scaled experiments which simulated a sodium-vapor expansion in a hypothetical core disruptive accident (HCDA) for the Fast Flux Test Facility. A non-condensible explosive source was used to model the pressure-volume expansion characteristics of sodium vapor as predicted by computer code calculations. Rigid piston-cylinder experiments ( 1 / 10 and 1 / 30 scale) were undertaken to determine these expansion characteristics. The results showed that the pressure-volume characteristics depend significantly on the presence of water in the cylinder reducing the work output by about 50 percent when a sufficient water depth was present. The study presented proposes that the mechanism of heat transfer between the water and high temperature gas was due to area enhancement by Taylor instabilities at the gas-liquid interface. A simple heat transfer model is proposed which describes this energy transport process and agrees well with the experimental data from both scaled experiments. The consequences of this analysis suggest that an estimate of the heat transfer to the cold slug during a full-scale HCDA due to sodium vapor expansion and the accompanying reduction in mechanical work energy warrants further investigation. The implication of this analysis is that for either sodium or fuel vapor expansion in an HCDA, there is an inherent heat transfer mechanism which significantly reduces the work output of the expanding bubble

  12. ROPUESTA DE MODELO EN CINCO CAPAS PARA APLICACIONES WEB I PROPOSAL OF A FIVE LAYERS MODEL FOR WEB APPLICATIONS

    Directory of Open Access Journals (Sweden)

    Loly Valentina Gómez Fermín

    2018-04-01

    Full Text Available The ability to create cross-platform programs is a goal for many software developers; however, it is complex to achieve. At present, web applications have been introduced as the chosen way to achieve this desired goal, but being the project tied to a software or hardware platform it is, inevitably, subject to obsolescence. This is not unique to the client application, but also applies to the server side, so that when developing software, even unwillingly, there are strings attached to a database and other applications. Because of this, to develop systems capable of operating with multiple databases and not dependent on a specific platform becomes a Herculean task for a development team. Therefore, this research proposes a working model which enables web applications capable of operating in a layered structure, where each defined layer can be replaced without the need to rewrite the other, and allowing real abstraction for application on any platform software or hardware, both on the client and server sides. For this purpose, the research is supported by Sommerville (2005, who presents a detailed classification of models of software development, according to its organization and modular decomposition, which layed the basis for the development of this proposal. This research is documentary in nature, since it is based on the collection of bibliographic material relating to existing software architectures.

  13. Proposed Model of Predicting the Reduced Yield Axial Load of Reinforced Concrete Columns Due to Casting Deficiency Effect

    Directory of Open Access Journals (Sweden)

    Achillopoulou Dimitra

    2014-12-01

    Full Text Available The study deals with the investigation of the effect of casting deficiencies- both experimentally and analytically on axial yield load or reinforced concrete columns. It includes 6 specimens of square section (150x150x500 mm of 24.37 MPa nominal concrete strength with 4 longitudinal steel bars of 8 mm (500 MPa nominal strength with confinement ratio ωc=0.15. Through casting procedure the necessary provisions defined by International Standards were not applied strictly in order to create construction deficiencies. These deficiencies are quantified geometrically without the use of expensive and expertise non-destructive methods and their effect on the axial load capacity of the concrete columns is calibrated trough a novel and simplified prediction model extracted by an experimental and analytical investigation that included 6 specimens. It is concluded that: a even with suitable repair, load reduction up to 22% is the outcome of the initial construction damage presence, b the lower dispersion is noted for the section damage index proposed, c extended damage alters the failure mode to brittle accompanied with longitudinal bars buckling, d the proposed model presents more than satisfying results to the load capacity prediction of repaired columns.

  14. Disturbed flow mediated modulation of shear forces on endothelial plane: A proposed model for studying endothelium around atherosclerotic plaques

    Science.gov (United States)

    Balaguru, Uma Maheswari; Sundaresan, Lakshmikirupa; Manivannan, Jeganathan; Majunathan, Reji; Mani, Krishnapriya; Swaminathan, Akila; Venkatesan, Saravanakumar; Kasiviswanathan, Dharanibalan; Chatterjee, Suvro

    2016-06-01

    Disturbed fluid flow or modulated shear stress is associated with vascular conditions such as atherosclerosis, thrombosis, and aneurysm. In vitro simulation of the fluid flow around the plaque micro-environment remains a challenging approach. Currently available models have limitations such as complications in protocols, high cost, incompetence of co-culture and not being suitable for massive expression studies. Hence, the present study aimed to develop a simple, versatile model based on Computational Fluid Dynamics (CFD) simulation. Current observations of CFD have shown the regions of modulated shear stress by the disturbed fluid flow. To execute and validate the model in real sense, cell morphology, cytoskeletal arrangement, cell death, reactive oxygen species (ROS) profile, nitric oxide production and disturbed flow markers under the above condition were assessed. Endothelium at disturbed flow region which had been exposed to low shear stress and swirling flow pattern showed morphological and expression similarities with the pathological disturbed flow environment reported previously. Altogether, the proposed model can serve as a platform to simulate the real time micro-environment of disturbed flow associated with eccentric plaque shapes and the possibilities of studying its downstream events.

  15. The catastrophic dieback of Typha domingensis in a drained and restored East Mediterranean wetland: re-examining proposed models

    Directory of Open Access Journals (Sweden)

    R. Simhayov

    2012-01-01

    Full Text Available We experimentally tested two geochemical models which have been proposed as potential mechanisms leading to the catastrophic dieback of Typha domingensis in constructed Lake Agmon within the drained Hula peatland, northern Israel. An elaborate lysimeter station simulating the conditions imposed by sulphide toxicity and P deficiency models was used to test them experimentally. Rhizosphere pH and redox potential were monitored in situ in real time throughout the summers of 2007 and 2008. A comparative study of redox-reduction simulation was coupled with periodic sampling and analysis of sulphide and other reducing species. N and P were determined in the plant tissues to compute the N:P nutrient limitation index and evaluate nutrient deficiencies. The sulphide toxicity model was not accepted as a viable mechanism because Typha domingensis stands did not show any signs of stress, even when growing in rhizosphere with a sulphide concentration three times that during the actual dieback in 1996. The P limitation model was not supported by the N:P index, which indicated N (16 limitation. Since Typha has now returned and is thriving in Lake Agmon and adjacent drainage canals, we suggest a self-thinning mechanism followed by normal succession of macrophytes in this relatively young constructed wetland as the most logical mechanism to explain the observed dieback.

  16. Investigating the empirical support for therapeutic targets proposed by the temporal experience of pleasure model in schizophrenia: A systematic review.

    Science.gov (United States)

    Edwards, Clementine J; Cella, Matteo; Tarrier, Nicholas; Wykes, Til

    2015-10-01

    Anhedonia and amotivation are substantial predictors of poor functional outcomes in people with schizophrenia and often present a formidable barrier to returning to work or building relationships. The Temporal Experience of Pleasure Model proposes constructs which should be considered therapeutic targets for these symptoms in schizophrenia e.g. anticipatory pleasure, memory, executive functions, motivation and behaviours related to the activity. Recent reviews have highlighted the need for a clear evidence base to drive the development of targeted interventions. To review systematically the empirical evidence for each TEP model component and propose evidence-based therapeutic targets for anhedonia and amotivation in schizophrenia. Following PRISMA guidelines, PubMed and PsycInfo were searched using the terms "schizophrenia" and "anhedonia". Studies were included if they measured anhedonia and participants had a diagnosis of schizophrenia. The methodology, measures and main findings from each study were extracted and critically summarised for each TEP model construct. 80 independent studies were reviewed and executive functions, emotional memory and the translation of motivation into actions are highlighted as key deficits with a strong evidence base in people with schizophrenia. However, there are many relationships that are unclear because the empirical work is limited by over-general tasks and measures. Promising methods for research which have more ecological validity include experience sampling and behavioural tasks assessing motivation. Specific adaptations to Cognitive Remediation Therapy, Cognitive Behavioural Therapy and the utilisation of mobile technology to enhance representations and emotional memory are recommended for future development. Copyright © 2015. Published by Elsevier B.V.

  17. Onset of rigor mortis is earlier in red muscle than in white muscle.

    Science.gov (United States)

    Kobayashi, M; Takatori, T; Nakajima, M; Sakurada, K; Hatanaka, K; Ikegaya, H; Matsuda, Y; Iwase, H

    2000-01-01

    Rigor mortis is thought to be related to falling ATP levels in muscles postmortem. We measured rigor mortis as tension determined isometrically in three rat leg muscles in liquid paraffin kept at 37 degrees C or 25 degrees C--two red muscles, red gastrocnemius (RG) and soleus (SO) and one white muscle, white gastrocnemius (WG). Onset, half and full rigor mortis occurred earlier in RG and SO than in WG both at 37 degrees C and at 25 degrees C even though RG and WG were portions of the same muscle. This suggests that rigor mortis directly reflects the postmortem intramuscular ATP level, which decreases more rapidly in red muscle than in white muscle after death. Rigor mortis was more retarded at 25 degrees C than at 37 degrees C in each type of muscle.

  18. Multiscale Model Simulations of Temperature and Relative Humidity for the License Application of the Proposed Yucca Mountain Repository

    Science.gov (United States)

    Buscheck, T.; Glascoe, L.; Sun, Y.; Gansemer, J.; Lee, K.

    2003-12-01

    For the proposed Yucca Mountain geologic repository for high-level nuclear waste, the planned method of disposal involves the emplacement of cylindrical packages containing the waste inside horizontal tunnels, called emplacement drifts, bored several hundred meters below the ground surface. The emplacement drifts reside in highly fractured, partially saturated volcanic tuff. An important phenomenological consideration for the licensing of the proposed repository at Yucca Mountain is the generation of decay heat by the emplaced waste and the consequences of this decay heat. Changes in temperature will affect the hydrologic and chemical environment at Yucca Mountain. A thermohydrologic-modeling tool is necessary to support the performance assessment of the Engineered Barrier System (EBS) of the proposed repository. This modeling tool must simultaneously account for processes occurring at a scale of a few tens of centimeters around individual waste packages, for processes occurring around the emplacement drifts themselves, and for processes occurring at the multi-kilometer scale of the mountain. Additionally, many other features must be considered including non-isothermal, multiphase-flow in fractured porous rock of variable liquid-phase saturation and thermal radiation and convection in open cavities. The Multiscale Thermohydrologic Model (MSTHM) calculates the following thermohydrologic (TH) variables: temperature, relative humidity, liquid-phase saturation, evaporation rate, air-mass fraction, gas-phase pressure, capillary pressure, and liquid- and gas-phase fluxes. The TH variables are determined as a function of position along each of the emplacement drifts in the repository and as a function of waste-package (WP) type. These variables are determined at various generic locations within the emplacement drifts, including the waste package and drip-shield surfaces and in the invert; they are also determined at various generic locations in the adjoining host rock

  19. IN BANGLADESH DIABETES STARTS EARLIER NOW THAN 10 YEARS BACK: A BIRDEM STUDY

    Directory of Open Access Journals (Sweden)

    Parvin Akter Khanam

    2008-01-01

    Full Text Available BIRDEM is the largest referral center of diabetes in the world. It registered more than 300,000 diabetic patients from 1956 to 2005. This retrospective study compared the biophysical characteristics of diabetic patients registered in 1995 to those registered in 2005. Information on social (income, education, clinical (height, weight, blood pressure and oral glucose tolerance (OGTT of patients registered in 1995 and 2005 were retrieved from the BIRDEM registry. The age group ³ 20y was considered eligible. Overall, there were 11489 patients for 1995 and 19580 for 2005. Compared with the registry of 1995, a significant increase of registry for female patients were observed (39.5 vs. 46.7%, p<0.001 and also the rural population (31.9 vs. 47.4%, p<0.001. Likewise, the number of poor social class was also found higher in 2005 (5.2 vs. 25.5%, p<0.001. Young aged (<40y registry was also significantly higher in 2005 (34.4 vs. 37.1%, p<0.001. Compared with the registered patients of 1995, adjusted for sex and area, those of 2005 had a significantly higher BMI, higher FPG and higher 2hPG (for all, p<0.001. In contrast, a significantly lower age, lower height and lower blood pressure were observed in those of 2005. We conclude that the age at registration for diabetes has decreased significantly in 2005 compared to that in 1995 indicating an earlier onset of diabetes. Significantly higher obesity in the year 2005 than 1995 indicates that there has been an increase in obesity that might be an important contributing factor for earlier onset of diabetes. Ibrahim Med. Coll. J. 2008; 2(1: 1-3

  20. Clinical presentation of retinoblastoma in Alexandria: A step toward earlier diagnosis.

    Science.gov (United States)

    Soliman, Sameh E; Eldomiaty, Wesam; Goweida, Mohamed B; Dowidar, Amgad

    2017-01-01

    To evaluate the clinical presentation of retinoblastoma in Alexandria, Egypt, correlate the timing of accurate diagnosis with the presence of advanced disease and identify causes of delayed presentation. Retrospective noncomparative single institution study reviews demographic and clinical data of all new children with retinoblastoma presenting to Alexandria Main University ocular oncology clinic (OOC) from January 2012 to June 2014. Diagnosis time was from initial parental complaint to retinoblastoma diagnosis and referral time was from retinoblastoma diagnosis to presentation to the Alexandria OCC. Delayed Diagnosis and referral were counted if >2 weeks. Advanced presentation is defined as clinical TNMH (8th edition) staging of cT2 or cT3 (international intraocular retinoblastoma classification group D or E) in at least one eye or the presence of extra-ocular disease (cT4). Seventy eyes of 47 children were eligible: 52% unilateral, 7% with family history and 96% presented with leukocorea. Sixty-four percent of children had advanced intraocular disease and none had extra-ocular disease. Delayed presentation occurred in 58% of children and was significantly associated with advanced disease in both unilaterally and bilaterally affected children (p = 0.003, 0.002 respectively). The delay in diagnosis was more in unilateral cases while the delay in referral was more in bilateral cases. The main cause of delayed presentation in unilateral retinoblastoma was misdiagnosis (30%) while parental shopping for second medical opinion (30%) was the main cause in bilateral children. Delayed diagnosis is a problem affecting retinoblastoma management. Better medical education and training, health education and earlier screening are recommended to achieve earlier diagnosis.

  1. Do BRCA1/2 mutation carriers have an earlier onset of natural menopause?

    Science.gov (United States)

    van Tilborg, Theodora C; Broekmans, Frank J; Pijpe, Anouk; Schrijver, Lieske H; Mooij, Thea M; Oosterwijk, Jan C; Verhoef, Senno; Gómez Garcia, Encarna B; van Zelst-Stams, Wendy A; Adank, Muriel A; van Asperen, Christi J; van Doorn, Helena C; van Os, Theo A; Bos, Anna M; Rookus, Matti A; Ausems, Margreet G

    2016-08-01

    It has been hypothesized that BRCA1/2 mutation carriers have an earlier age at natural menopause (ANM), although to date findings are inconclusive. This study assessed the influence of BRCA mutation status on ANM, and aimed to explore the reasons of inconsistency in the literature. Cross-sectional assessment from an ongoing nationwide cohort study among members of BRCA1/2 mutated families. Information was obtained by a standardized questionnaire. Kaplan-Meier curves were constructed, and Cox regression was used to assess the association between BRCA1/2 mutation status and ANM. Adjustments were made for birth cohort, family, smoking, use of hormonal contraceptives, and parity. A total of 1,208 BRCA1/2 mutation carriers and 2,211 proven noncarriers were included. Overall, no association was found between BRCA1/2 mutation status and ANM (adjusted hazard ratio [HR] = 1.06 [95% CI, 0.87-1.30]). We examined if the null finding was due to informative censoring by uptake of risk-reducing salpingo-oophorectomy. Indeed, within the oldest birth cohort, in which the percentage of surgical menopause events was lowest and comparable between carriers and noncarriers, the HR for earlier natural menopause in carriers was 1.45 (95% CI, 1.09-1.94). The second oldest birth cohort, however, demonstrated a decreased HR (0.67 [95% CI, 0.46-0.98]), and thus no trend over birth cohorts was found. Various types of selection bias hamper the comparison of ANM between BRCA1/2 mutation carriers and noncarriers, genetically tested in the clinic.

  2. Proposal of a model of system of identification for domestic animals: a comparison between brazilian and international laws

    Directory of Open Access Journals (Sweden)

    Nicolau Cardoso Neto

    2016-09-01

    Full Text Available The relationship between humans and pets, especially dogs and cats is taking gigantic proportions, this can be seen by the data recently published by IBGE, where it was verified that the number of pets grows more than the number of child birth (IBGE, 2015. As so foreseen, the purpose of this study is to acknowledge which is the federal juridical basis related to the registration of Domestic Animals in Brazil, comparing them with the international legal standards that can be of reference, such as Canada, United States of America, Republic of Ireland and United Kingdom. This increase in pet population shows problems of many dimensions that relate to several causes in urban centers, especially when referring to zoonosis and conflicts that come from irresponsible ownership, bringing up a public health issue. The intension was to verify the possibility to adequate them to the reality encountered in Brazil, creating a model of identification for the Domestic Animals in urban areas in this country. As for that, the article addresses themes related to responsible ownership, animal welfare and models of registration already accomplished in the mentioned countries. At the end the article presents the proposal of a model for a system of identification of the Domestic Animals.

  3. Three-dimensional modeling of unsaturated flow in the vicinity of proposed exploratory shaft facilities at Yucca Mountain, Nevada

    International Nuclear Information System (INIS)

    Rockhold, M.L.; Sagar, B.; Connelly, M.P.

    1992-04-01

    This report describes the results of a study to investigate the influence of proposed exploratory shafts on the moisture distribution within unsaturated, fractured rock at Yucca Mountain, Nevada. The long-term effects of exploratory shafts at Yucca Mountain are important in the estimation of potential waste migration and fate, while short-term effects may be important in the planning and interpretation of tests performed at the site. The PORFLO-3 computer code was used for simulation of moisture flow through the geologic units adjacent to the ESF. Rather than represent fractures as discrete elements, an equivalent continuum was stipulated, in which the fractured units were assigned equivalent or composite hydrologic properties. Explicit treatment of fractures is not feasible because of the extremely large number of fractures contained in the site-scale problem and the difficulties in characterizing and modeling the fracture geometries

  4. A Model Proposal on the Use of Creative Tourism Experiences in Congress Tourism and the Congress Marketing Mix

    Directory of Open Access Journals (Sweden)

    Özen Kırant Yozcu

    2010-04-01

    Full Text Available Congress tourism has a great importance for the extension of the tourism season, enhancement of employment opportunities and tourism revenues, promotion and efficient use of the facilities in the area. Creative Tourism provides an authentic feel for a local culture through informal, hands-on workshops and creative experiences. Ensuring that the attendants of congress tourism take part in creative tourism activities may be an example of the synergy to be achieved by including creative tourism in thecongress marketing mix. In this study the tourism marketing mix, programming, packaging, partnership, people, product, price, promotion, place, are adapted for congress tourism and a model which illustrates how to use the creative tourism experiences and activities within the marketing mix is proposed.

  5. A model for determining when an analysis contains sufficient detail to provide adequate NEPA coverage for a proposed action

    International Nuclear Information System (INIS)

    Eccleston, C.H.

    1994-11-01

    Neither the National Environmental Policy Act (NEPA) nor its subsequent regulations provide substantive guidance for determining the Level of detail, discussion, and analysis that is sufficient to adequately cover a proposed action. Yet, decisionmakers are routinely confronted with the problem of making such determinations. Experience has shown that no two decisionmakers are Likely to completely agree on the amount of discussion that is sufficient to adequately cover a proposed action. one decisionmaker may determine that a certain Level of analysis is adequate, while another may conclude the exact opposite. Achieving a consensus within the agency and among the public can be problematic. Lacking definitive guidance, decisionmakers and critics alike may point to a universe of potential factors as the basis for defending their claim that an action is or is not adequately covered. Experience indicates that assertions are often based on ambiguous opinions that can be neither proved nor disproved. Lack of definitive guidance slows the decisionmaking process and can result in project delays. Furthermore, it can also Lead to inconsistencies in decisionmaking, inappropriate Levels of NEPA documentation, and increased risk of a project being challenged for inadequate coverage. A more systematic and less subjective approach for making such determinations is obviously needed. A paradigm for reducing the degree of subjectivity inherent in such decisions is presented in the following paper. The model is specifically designed to expedite the decisionmaking process by providing a systematic approach for making these determination. In many cases, agencies may find that using this model can reduce the analysis and size of NEPA documents

  6. Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy.

    Science.gov (United States)

    Babayan, Simon A; Read, Andrew F; Lawrence, Rachel A; Bain, Odile; Allen, Judith E

    2010-10-19

    Humans and other mammals mount vigorous immune assaults against helminth parasites, yet there are intriguing reports that the immune response can enhance rather than impair parasite development. It has been hypothesized that helminths, like many free-living organisms, should optimize their development and reproduction in response to cues predicting future life expectancy. However, immune-dependent development by helminth parasites has so far eluded such evolutionary explanation. By manipulating various arms of the immune response of experimental hosts, we show that filarial nematodes, the parasites responsible for debilitating diseases in humans like river blindness and elephantiasis, accelerate their development in response to the IL-5 driven eosinophilia they encounter when infecting a host. Consequently they produce microfilariae, their transmission stages, earlier and in greater numbers. Eosinophilia is a primary host determinant of filarial life expectancy, operating both at larval and at late adult stages in anatomically and temporally separate locations, and is implicated in vaccine-mediated protection. Filarial nematodes are therefore able to adjust their reproductive schedules in response to an environmental predictor of their probability of survival, as proposed by evolutionary theory, thereby mitigating the effects of the immune attack to which helminths are most susceptible. Enhancing protective immunity against filarial nematodes, for example through vaccination, may be less effective at reducing transmission than would be expected and may, at worst, lead to increased transmission and, hence, pathology.

  7. Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy.

    Directory of Open Access Journals (Sweden)

    Simon A Babayan

    Full Text Available Humans and other mammals mount vigorous immune assaults against helminth parasites, yet there are intriguing reports that the immune response can enhance rather than impair parasite development. It has been hypothesized that helminths, like many free-living organisms, should optimize their development and reproduction in response to cues predicting future life expectancy. However, immune-dependent development by helminth parasites has so far eluded such evolutionary explanation. By manipulating various arms of the immune response of experimental hosts, we show that filarial nematodes, the parasites responsible for debilitating diseases in humans like river blindness and elephantiasis, accelerate their development in response to the IL-5 driven eosinophilia they encounter when infecting a host. Consequently they produce microfilariae, their transmission stages, earlier and in greater numbers. Eosinophilia is a primary host determinant of filarial life expectancy, operating both at larval and at late adult stages in anatomically and temporally separate locations, and is implicated in vaccine-mediated protection. Filarial nematodes are therefore able to adjust their reproductive schedules in response to an environmental predictor of their probability of survival, as proposed by evolutionary theory, thereby mitigating the effects of the immune attack to which helminths are most susceptible. Enhancing protective immunity against filarial nematodes, for example through vaccination, may be less effective at reducing transmission than would be expected and may, at worst, lead to increased transmission and, hence, pathology.

  8. Proposal of performance indicators/model for Operational Readiness Verification (ORV) at restart after a planned shutdown

    International Nuclear Information System (INIS)

    Hollnagel, Erik; Nygren, Magnus

    2005-12-01

    The objectives of the study reported here were to propose a model that can be used in the analysis of possible future ORV-related events and to outline a set of performance indicators that can be used by the inspectorate to assess a utility's level of readiness if an ORV-event should take place. Together the two objectives serve to improve the inspectorate's ability to ensure that the utilities maintain an adequate capability to respond. The background for the current study is the nine ORV events that occurred in Sweden between 1995- 1998, as well as the findings of a previous study of safety during outage and restart of nuclear power plants project. This study found that the three levels or types of tests that occur in ORV were used according to need rather than according to a predefined arrangement or procedure, and that tasks were adapted relative to the different types of embedding and the degree of correspondence between nominal and actual ORV. The organisation's coping with the complexity of ORV was discussed by the relation between expectations and surprises, how planning was used as control, attention to details, and the practices of shift changes. It is a truism that accidents are analysed and interpreted relative to a commonly accepted understanding of their nature. This understanding is, however, relative rather than absolute, and has changed significantly during the last decade. In the 1990s, accidents were analysed step by step, and explanations and recommendations therefore emphasised specific rather than generic solutions. The present study illustrates this by going through the responses to the nine ORV events. Following that, the nine events are analysed anew using a contemporary understanding of accidents (a systemic model), which emphasises that incidents more often arise from context induced performance variability than from failures of people. The alternative interpretation provided by a systemic model is illustrated by a detailed analysis of

  9. Earlier onset of motor deficits in mice with double mutations in Dyt1 and Sgce.

    Science.gov (United States)

    Yokoi, Fumiaki; Yang, Guang; Li, Jindong; DeAndrade, Mark P; Zhou, Tong; Li, Yuqing

    2010-10-01

    DYT1 early-onset generalized torsion dystonia is an inherited movement disorder caused by mutations in DYT1 coding for torsinA with ∼30% penetrance. Most of the DYT1 dystonia patients exhibit symptoms during childhood and adolescence. On the other hand, DYT1 mutation carriers without symptoms during these periods mostly do not exhibit symptoms later in their life. Little is known about what controls the timing of the onset, a critical issue for DYT1 mutation carriers. DYT11 myoclonus-dystonia is caused by mutations in SGCE coding for ε-sarcoglycan. Two dystonia patients from a single family with double mutations in DYT1 and SGCE exhibited more severe symptoms. A recent study suggested that torsinA contributes to the quality control of ε-sarcoglycan. Here, we derived mice carrying mutations in both Dyt1 and Sgce and found that these double mutant mice showed earlier onset of motor deficits in beam-walking test. A novel monoclonal antibody against mouse ε-sarcoglycan was developed by using Sgce knock-out mice to avoid the immune tolerance. Western blot analysis suggested that functional deficits of torsinA and ε-sarcoglycan may independently cause motor deficits. Examining additional mutations in other dystonia genes may be beneficial to predict the onset in DYT1 mutation carriers.

  10. Safety of reactors built according to earlier standards (WWER 440/V230 type)

    International Nuclear Information System (INIS)

    Misak, J.; Rohar, S.

    1995-01-01

    The problems of safety of WWER-440/V-230 type reactors are discussed, and the following conclusions are made. (1) The reactors have a very good operational record. (2) The reactors have serious design shortcomings, which should be eliminated by safety upgrading. Core damage frequency should be further reduced. (3) PSA methods constitute an appropriate tool for assessment of plant vulnerability to some initiating events and malfunctions, for prioritization of upgrading measures and for tolerability of deviations from current safety standards. (4) The most important safety merits, such as a large thermal inertia and low rupture probability, should be properly taken into account in the analysis. (5) Extensive safety upgrading is feasible and can lead to a considerable risk reduction. In certain circumstances such upgrading is the least expensive option even though the total cost is much higher than the initial plant construction cost. (6) Properly upgraded, the reactor units may be operable until better power resources are available within the country. (7) The existing gap between the technological and political judgements of nuclear safety should be reduced continuously by information exchange improvements. (8) A unified approach to nuclear safety should be adopted for all nuclear reactors (not just WWERs) built to earlier standards. 5 tabs., 1 fig

  11. Earlier Snowmelt Changes the Ratio Between Early and Late Season Forest Productivity

    Science.gov (United States)

    Knowles, J. F.; Molotch, N. P.; Trujillo, E.; Litvak, M. E.

    2017-12-01

    Future projections of declining snowpack and increasing potential evaporation associated with climate warming are predicted to advance the timing of snowmelt in mountain ecosystems globally. This scenario has direct implications for snowmelt-driven forest productivity, but the net effect of temporally shifting moisture dynamics is unknown with respect to the annual carbon balance. Accordingly, this study uses both satellite- and tower-based observations to document the forest productivity response to snowpack and potential evaporation variability between 1989 and 2012 throughout the southern Rocky Mountain ecoregion, USA. These results show that a combination of low snow accumulation and record high potential evaporation in 2012 resulted in the 34-year minimum ecosystem productivity that could be indicative of future conditions. Moreover, early and late season productivity were significantly and inversely related, suggesting that future shifts toward earlier or reduced snowmelt could increase late-season moisture stress to vegetation and thus restrict productivity despite a longer growing season. This relationship was further subject to modification by summer precipitation, and the controls on the early/late season productivity ratio are explored within the context of ecosystem carbon storage in the future. Any perturbation to the carbon cycle at this scale represents a potential feedback to climate change since snow-covered forests represent an important global carbon sink.

  12. Proposed Method for Disaggregation of Secondary Data: The Model for External Reliance of Localities in the Coastal Management Zone (MERLIN-CMZ)

    Science.gov (United States)

    The Model for External Reliance of Localities In (MERLIN) Coastal Management Zones is a proposed solution to allow scaling of variables to smaller, nested geographies. Utilizing a Principal Components Analysis and data normalization techniques, smaller scale trends are linked to ...

  13. Can theory be embedded in visual interventions to promote self-management? A proposed model and worked example.

    Science.gov (United States)

    Williams, B; Anderson, A S; Barton, K; McGhee, J

    2012-12-01

    Nurses are increasingly involved in a range of strategies to encourage patient behaviours that improve self-management. If nurses are to be involved in, or indeed lead, the development of such interventions then processes that enhance the likelihood that they will lead to evidence that is both robust and usable in practice are required. Although behavioural interventions have been predominantly based on written text or the spoken word increasing numbers are now drawing on visual media to communicate their message, despite only a growing evidence base to support it. The use of such media in health interventions is likely to increase due to technological advances enabling easier and cheaper production, and an increasing social preference for visual forms of communication. However, the development of such media is often highly pragmatic and developed intuitively rather than with theory and evidence informing their content and form. Such a process may be at best inefficient and at worst potentially harmful. This paper performs two functions. Firstly, it discusses and argues why visual based interventions may be a powerful media for behaviour change; and secondly, it proposes a model, developed from the MRC Framework for the Development and Evaluation of Complex Interventions, to guide the creation of theory informed visual interventions. It employs a case study of the development of an intervention to motivate involvement in a lifestyle intervention among people with increased cardiovascular risk. In doing this we argue for a step-wise model which includes: (1) the identification of a theoretical basis and associated concepts; (2) the development of visual narrative to establish structure; (3) the visual rendering of narrative and concepts; and (4) the assessment of interpretation and impact among the intended patient group. We go on to discuss the theoretical and methodological limitations of the model. Copyright © 2012 Elsevier Ltd. All rights reserved.

  14. Proposal of a clinical typing system and generation of a prognostic model in patients with nasopharyngeal carcinoma from Southern China.

    Science.gov (United States)

    Sun, Peng; Chen, Cui; Chen, Xin-Lin; Cheng, Yi-Kan; Zeng, Lei; Zeng, Zhi-Jian; Liu, Li-Zhi; Su, Yong; Gu, Mo-Fa

    2014-01-01

    To propose a novel clinical typing classification focusing on the distinct progression patterns of nasopharyngeal carcinoma (NPC), to supplement our knowledge of the clinical-biological behavior, to provide useful knowledge for treatment planning, and to contribute to basic research in NPC. 632 consecutive patients were retrospectively reviewed and analyzed according to the novel typing system. We considered that NPC can be divided into 5 types as follows: limited (L), ascending (A), descending (D) ascending- descending (mixed) (AD), and distant metastasis types (M). The distribution of these clinical types, their association with Epstein-Barr virus (EBV) serology and prognostic value were explored. 55 (8.70%), 59 (9.34%), 177 (28.01%), 321 (50.79%) and 20 (3.16%) patients were classified as Type L, A, D, AD and M, respectively. EBV (VCA)-IgA titers, EBV early antigen (EA)-IgA serum titers, and capsid antigen lg(EBV DNA) were positively associated with the clinical typing (pTypes L, A, D, AD and M were 100, 100, 95.10, 88.20 and 59.30%, respectively (ptype, which were independent predictors of OS (multivariate Cox proportional model). The prognostic model stratified patients into 4 risk subgroups. The 3-year OS rates of the low, intermediate, high and extremely high risk groups were 99.5, 90.0, 85.5 and 53.2%, respectively (ptyping system and prognostic model can supplement TNM classification, and may help design novel treatment strategies, evaluate risk stratification and investigate the varied biological characteristics of NPC.

  15. Model simulations of potential contribution of the proposed Huangpu Gate to flood control in the Lake Taihu basin of China

    Science.gov (United States)

    Zhang, Hanghui; Liu, Shuguang; Ye, Jianchun; Yeh, Pat J.-F.

    2017-10-01

    The Lake Taihu basin (36 895 km2), one of the most developed regions in China located in the hinterland of the Yangtze River Delta, has experienced increasing flood risk. The largest flood in history occurred in 1999 with a return period estimate of 200 years, considerably larger than the current capacity of the flood defense with a design return period of 50 years. Due to its flat saucer-like terrain, the capacity of the flood control system in this basin depends on flood control infrastructures and peripheral tidal conditions. The Huangpu River, an important river of the basin connecting Lake Taihu upstream and Yangtze River estuaries downstream, drains two-fifths of the entire basin. Since the water level in the Huangpu River is significantly affected by the high tide conditions in estuaries, constructing an estuary gate is considered an effective solution for flood mitigation. The main objective of this paper is to assess the potential contributions of the proposed Huangpu Gate to the flood control capacity of the basin. To achieve this goal, five different scenarios of flooding conditions and the associated gate operations are considered by using numerical model simulations. Results of quantitative analyses show that the Huangpu Gate is effective for evacuating floodwaters. It can help to reduce both peak values and duration of high water levels in Lake Taihu to benefit surrounding areas along the Taipu Canal and the Huangpu River. The contribution of the gate to the flood control capacity is closely associated with its operation modes and duration. For the maximum potential contribution of the gate, the net outflow at the proposed site is increased by 52 %. The daily peak level is decreased by a maximum of 0.12 m in Lake Taihu, by maxima of 0.26-0.37 and 0.46-0.60 m in the Taipu Canal and the Huangpu River, respectively, and by 0.05-0.39 m in the surrounding areas depending on the local topography. It is concluded that the proposed Huangpu Gate can reduce

  16. Proposed actions are no actions: re-modeling an ontology design pattern with a realist top-level ontology.

    Science.gov (United States)

    Seddig-Raufie, Djamila; Jansen, Ludger; Schober, Daniel; Boeker, Martin; Grewe, Niels; Schulz, Stefan

    2012-09-21

    Ontology Design Patterns (ODPs) are representational artifacts devised to offer solutions for recurring ontology design problems. They promise to enhance the ontology building process in terms of flexibility, re-usability and expansion, and to make the result of ontology engineering more predictable. In this paper, we analyze ODP repositories and investigate their relation with upper-level ontologies. In particular, we compare the BioTop upper ontology to the Action ODP from the NeOn an ODP repository. In view of the differences in the respective approaches, we investigate whether the Action ODP can be embedded into BioTop. We demonstrate that this requires re-interpreting the meaning of classes of the NeOn Action ODP in the light of the precepts of realist ontologies. As a result, the re-design required clarifying the ontological commitment of the ODP classes by assigning them to top-level categories. Thus, ambiguous definitions are avoided. Classes of real entities are clearly distinguished from classes of information artifacts. The proposed approach avoids the commitment to the existence of unclear future entities which underlies the NeOn Action ODP. Our re-design is parsimonious in the sense that existing BioTop content proved to be largely sufficient to define the different types of actions and plans. The proposed model demonstrates that an expressive upper-level ontology provides enough resources and expressivity to represent even complex ODPs, here shown with the different flavors of Action as proposed in the NeOn ODP. The advantage of ODP inclusion into a top-level ontology is the given predetermined dependency of each class, an existing backbone structure and well-defined relations. Our comparison shows that the use of some ODPs is more likely to cause problems for ontology developers, rather than to guide them. Besides the structural properties, the explanation of classification results were particularly hard to grasp for 'self-sufficient' ODPs as

  17. Earlier surgical intervention in congenital heart disease results in better outcome and resource utilization.

    Science.gov (United States)

    Panni, Roheena Z; Ashfaq, Awais; Amanullah, Muhammad M

    2011-12-29

    Congenital heart disease (CHD) accounts for a major proportion of disease in the pediatric age group. The objective of the study was to estimate the cost of illness associated with CHD pre, intra and postoperatively; among patients referred to a tertiary care hospital in Karachi, Pakistan. This is the first study conducted to estimate the cost of managing CHD in Pakistan. A prevalence based cost of illness study design was used to estimate the cost of cardiac surgery (corrective & palliative) for congenital heart defects in children ≤ 5 years of age from June 2006 to June 2009. A total of 120 patients were enrolled after obtaining an informed consent and the data was collected using a pre-tested questionnaire. The mean age at the time of surgery in group A (1-12 mo age) was 6.08 ± 2.80 months and in group B (1-5 yrs) was 37.10 ± 19.94 months. The cost of surgical admission was found to be significantly higher in the older group, p = 0.001. The total number and cost of post-operative outpatient visits was also higher in group B, p = 0.003. Pre and post operative hospital admissions were not found to be significantly different among the two groups, p = 0.166 and 0.627, respectively. The number of complications were found to be different between the two groups (p = 0.019). Majority of these were contributed by hemorrhage and post-operative seizures. This study concluded that significant expenditure is incurred by people with CHD; with the implication that resources could be saved by earlier detection and awareness campaigns.

  18. Selection for earlier flowering crop associated with climatic variations in the Sahel.

    Directory of Open Access Journals (Sweden)

    Yves Vigouroux

    Full Text Available Climate changes will have an impact on food production and will require costly adaptive responses. Adapting to a changing environment will be particularly challenging in sub-Saharan Africa where climate change is expected to have a major impact. However, one important phenomenon that is often overlooked and is poorly documented is the ability of agro-systems to rapidly adapt to environmental variations. Such an adaptation could proceed by the adoption of new varieties or by the adaptation of varieties to a changing environment. In this study, we analyzed these two processes in one of the driest agro-ecosystems in Africa, the Sahel. We performed a detailed study in Niger where pearl millet is the main crop and covers 65% of the cultivated area. To assess how the agro-system is responding to recent recurrent drought, we analyzed samples of pearl millet landraces collected in the same villages in 1976 and 2003 throughout the entire cultivated area of Niger. We studied phenological and morphological differences in the 1976 and 2003 collections by comparing them over three cropping seasons in a common garden experiment. We found no major changes in the main cultivated varieties or in their genetic diversity. However, we observed a significant shift in adaptive traits. Compared to the 1976 samples, samples collected in 2003 displayed a shorter lifecycle, and a reduction in plant and spike size. We also found that an early flowering allele at the PHYC locus increased in frequency between 1976 and 2003. The increase exceeded the effect of drift and sampling, suggesting a direct effect of selection for earliness on this gene. We conclude that recurrent drought can lead to selection for earlier flowering in a major Sahelian crop. Surprisingly, these results suggest that diffusion of crop varieties is not the main driver of short term adaptation to climatic variation.

  19. Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests.

    Science.gov (United States)

    Felipo, Vicente; Urios, Amparo; Giménez-Garzó, Carla; Cauli, Omar; Andrés-Costa, Maria-Jesús; González, Olga; Serra, Miguel A; Sánchez-González, Javier; Aliaga, Roberto; Giner-Durán, Remedios; Belloch, Vicente; Montoliu, Carmina

    2014-09-07

    To assess whether non invasive blood flow measurement by arterial spin labeling in several brain regions detects minimal hepatic encephalopathy. Blood flow (BF) was analyzed by arterial spin labeling (ASL) in different brain areas of 14 controls, 24 cirrhotic patients without and 16 cirrhotic patients with minimal hepatic encephalopathy (MHE). Images were collected using a 3 Tesla MR scanner (Achieva 3T-TX, Philips, Netherlands). Pulsed ASL was performed. Patients showing MHE were detected using the battery Psychometric Hepatic Encephalopathy Score (PHES) consisting of five tests. Different cognitive and motor functions were also assessed: alterations in selective attention were evaluated using the Stroop test. Patients and controls also performed visuo-motor and bimanual coordination tests. Several biochemical parameters were measured: serum pro-inflammatory interleukins (IL-6 and IL-18), 3-nitrotyrosine, cGMP and nitrates+nitrites in plasma, and blood ammonia. Bivariate correlations were evaluated. In patients with MHE, BF was increased in cerebellar hemisphere (P = 0.03) and vermis (P = 0.012) and reduced in occipital lobe (P = 0.017). BF in cerebellar hemisphere was also increased in patients without MHE (P = 0.02). Bimanual coordination was impaired in patients without MHE (P = 0.05) and much more in patients with MHE (P battery and with CFF. BF in cerebellar hemisphere correlates with plasma cGMP and nitric oxide (NO) metabolites. BF in vermis cerebellar also correlates with NO metabolites and with 3-nitrotyrosine. IL-18 in plasma correlates with BF in thalamus and occipital lobe. Non invasive BF determination in cerebellum using ASL may detect MHE earlier than the PHES. Altered NO-cGMP pathway seems to be associated to altered BF in cerebellum.

  20. Analysis of radioactive corrosion test specimens by means of ICP-MS. Comparison with earlier methods

    International Nuclear Information System (INIS)

    Forsyth, Roy

    1997-07-01

    In June 1992, an ICP-MS instrument (Inductively Coupled Plasma-Mass Spectrometry) was commissioned for use with radioactive sample solutions at Studsvik Nuclear's Hot Cell Laboratory. For conventional environmental samples the instrument permits the simultaneous analysis of many trace elements, but the software used in evaluation of the mass spectra is based on a library of isotopic compositions relevant only for elements in the lithosphere. Fission products and actinides, however, have isotopic compositions which are significantly different from the natural elements, and which also vary with the burnup of the nuclear fuel specimen. Consequently, a spread-sheet had to be developed which could evaluate the mass spectra with these isotopic compositions. Following these preparations, a large number of samples (about 200) from SKB's experimental programme for the study of spent fuel corrosion have been analyzed by the ICP-MS technique. Many of these samples were archive solutions of samples which had been taken earlier in the programme. This report presents a comparison of the analytical results for uranium, plutonium, cesium, strontium and technetium by both the ICP-MS technique, and the previously used analytical methods. For three products, a satisfactory agreement between the results from the various methods was obtained, but for uranium and plutonium the ICP-MS method gave results which were 10-20% higher than the conventional methods. The comparison programme has also shown, not unexpectedly, that significant losses of plutonium from solution had occurred, by precipitation and/or absorption, in the archive solutions during storage. It can be expected that such losses also occur for the other actinides, and consequently, all the analytical results for actinides in older archive solutions must be treated with great caution. 9 refs

  1. Metamorphosis Is Ancestral for Crown Euarthropods, and Evolved in the Cambrian or Earlier.

    Science.gov (United States)

    Wolfe, Joanna M

    2017-09-01

    Macroevolutionary developmental biology employs fossilized ontogenetic data and phylogenetic comparative methods to probe the evolution of development at ancient nodes. Despite the prevalence of ecologically differentiated larval forms in marine invertebrates, it has been frequently presumed that the ancestors of arthropods were direct developers, and that metamorphosis may not have evolved until the Ordovician or later. Using fossils and new dated phylogenies, I infer that metamorphosis was likely ancestral for crown arthropods, contradicting this assumption. Based on a published morphological dataset encompassing 217 exceptionally preserved fossil and 96 extant taxa, fossils were directly incorporated into both the topology and age estimates, as in "tip dating" analyses. Using data from post-embryonic fossils representing 25 species throughout stem and crown arthropod lineages (as well as most of the 96 extant taxa), characters for metamorphosis were assigned based on inferred ecological changes in development (e.g., changes in habitat and adaptive landscape). Under all phylogenetic hypotheses, metamorphosis was supported as most likely ancestral to both ecdysozoans and euarthropods. Care must be taken to account for potential drastic post-embryonic morphological changes in evolutionary analyses. Many stem group euarthrpods may have had ecologically differentiated larval stages that did not preserve in the fossil record. Moreover, a complex life cycle and planktonic ecology may have evolved in the Ediacaran or earlier, and may have typified the pre-Cambrian explosion "wormworld" prior to the origin of crown group euarthropods. © The Author 2017. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

  2. Multiscale Thermohydrologic Model Analyses of Heterogeneity and Thermal-Loading Factors for the Proposed Repository at Yucca Mountain

    International Nuclear Information System (INIS)

    Glascoe, L.G.; Buscheck, T.A.; Gansemer, J.; Sun, Y.; Lee, K.

    2002-01-01

    The MultiScale ThermoHydrologic Model (MSTHM) predicts thermohydrologic (TH) conditions in emplacement drifts and the adjoining host rock throughout the proposed nuclear-waste repository at Yucca Mountain. The MSTHM is a computationally efficient approach that accounts for TH processes occurring at a scale of a few tens of centimeters around individual waste packages and emplacement drifts, and for heat flow at the multi-kilometer scale at Yucca Mountain. The modeling effort presented here is an early investigation of the repository and is simulated at a lower temperature mode and with a different panel loading than the repository currently being considered for license application. We present these recent lower temperature mode MSTHM simulations that address the influence of repository-scale thermal-conductivity heterogeneity and the influence of preclosure operational factors affecting thermal-loading conditions. We can now accommodate a complex repository layout with emplacement drifts lying in non-parallel planes using a superposition process that combines results from multiple mountain-scale submodels. This development, along with other improvements to the MSTHM, enables more rigorous analyses of preclosure operational factors. These improvements include the ability to (1) predict TH conditions on a drift-by-drift basis, (2) represent sequential emplacement of waste packages along the drifts, and (3) incorporate distance- and time-dependent heat-removal efficiency associated with drift ventilation. Alternative approaches to addressing repository-scale thermal-conductivity heterogeneity are investigated. We find that only one of the four MSTHM submodel types needs to incorporate thermal-conductivity heterogeneity. For a particular repository design, we find that the most influential parameters are (1) percolation-flux distribution, (2) thermal-conductivity heterogeneity within the host-rock units, (3) the sequencing of waste-package emplacement, and (4) the

  3. Technological Innovation Projects: Proposal For an Integrative Model Between Project Management and Knowledge Management in a Customer-Supplier Perspective

    Directory of Open Access Journals (Sweden)

    Edval da Silva Tavares

    2014-10-01

    Full Text Available In face of strong competition, companies in Brazil have increased their financial investments in automation, offering new products and services and reducing operating costs. These companies are focusing their efforts on core competencies and, therefore, they often lack the internal expertise to implement new projects, especially those that bring technological innovation. For this reason, we use the processes of outsourcing or subcontracting to help implement such projects. The unit of analysis in this study is the project and the object of the study to analyze the process of knowledge transfer from a provider to a customer during the duration of the project, which involves new technologies. The main motivation of this work is to address the acquisition and retention of new knowledge related to projects designed for business customers. We have developed a study of three cases of multiple financial firms that buy new technologies and two suppliers of information technology. As a practical result, a management model of knowledge transfer and retention of knowledge in client companies is proposed and incorporated into project management.

  4. Sustainable production of broiler chicken and laying hen: bibliographical review and proposal of a model for small producers

    Directory of Open Access Journals (Sweden)

    Diana Milena Soler F.

    2011-05-01

    Full Text Available The peasant production of broiler chicken and laying hens in the world is wide, being the developing countries which most productions of this type arise. 'ese backyard holdings play an important role as they ensure the consumption of protein products and a subsistence economy to poor families. Due to the low number of technical and scientific studies on these extensive systems in the department of Boyacá, this work aimed to establish by general literature review the world, national and regional state of the art in the production of broiler chicken and alternatively laying hen, and as specific objectives, to produce an analysis of the diferent managements and plans and propose a production model that suits the needs of small producers. the results of the world’s state of the art showed that all countries have a variety of peasant farms, but there is a clear path to commercialization of these poultry farming products, renowned for their safety and quality of nutrients. In some municipalities in Boyacá, these farmers have favorable production systems and yields earnings due to the reduced production costs by the introduction of crop products and recyclable materials, and also have no significant environmental impacts, however, health management is poor and animal feeding starts to rely on concentrated foods.

  5. The Anti-Inflammatory Effects of Acupuncture and Their Relevance to Allergic Rhinitis: A Narrative Review and Proposed Model

    Directory of Open Access Journals (Sweden)

    John L. McDonald

    2013-01-01

    Full Text Available Classical literature indicates that acupuncture has been used for millennia to treat numerous inflammatory conditions, including allergic rhinitis. Recent research has examined some of the mechanisms underpinning acupuncture's anti-inflammatory effects which include mediation by sympathetic and parasympathetic pathways. The hypothalamus-pituitary-adrenal (HPA axis has been reported to mediate the antioedema effects of acupuncture, but not antihyperalgesic actions during inflammation. Other reported anti-inflammatory effects of acupuncture include an antihistamine action and downregulation of proinflammatory cytokines (such as TNF-α, IL-1β, IL-6, and IL-10, proinflammatory neuropeptides (such as SP, CGRP, and VIP, and neurotrophins (such as NGF and BDNF which can enhance and prolong inflammatory response. Acupuncture has been reported to suppress the expression of COX-1, COX-2, and iNOS during experimentally induced inflammation. Downregulation of the expression and sensitivity of the transient receptor potential vallinoid 1 (TRPV1 after acupuncture has been reported. In summary, acupuncture may exert anti-inflammatory effects through a complex neuro-endocrino-immunological network of actions. Many of these generic anti-inflammatory effects of acupuncture are of direct relevance to allergic rhinitis; however, more research is needed to elucidate specifically how immune mechanisms might be modulated by acupuncture in allergic rhinitis, and to this end a proposed model is offered to guide further research.

  6. Proposing a Model for Patient Admission and NFC Mobile Payment by Biometric Identification and Smart Health Card

    Directory of Open Access Journals (Sweden)

    Mahdi Barkhordari Firouzabadi

    2016-02-01

    Full Text Available Abstract Following the advances in mobile communication and information technology, smart phones have been used in a wide variety of commercial, social, entertainment, file sharing and health transactions and applications. The current procedures in healthcare environment for patient registration, appointment scheduling and payment are time consuming and somehow tiresome. Traditionally, patients were supposed to fill out registration forms, wait for being called, and finally stand in long lines for payment procedures. In some places, appointment could be done online via web but still the patient has to walk in with appointment card and in our case, provide the insurance booklet to the front desk personnel to pay for services and receive discounts for insurance. Therefore, the present study intended to propose a model using Near Field Communication-enabled mobile application for a medical clinic which currently offers online and call services for making an appointment, though patient waiting time is still too much in the current process of payment for services.

  7. Competitive advantage and the existence of the multinational corporation: earlier research and the role of frictions

    OpenAIRE

    Asmussen, Christian Geisler; Foss, Nicolai J.

    2014-01-01

    This article provides a counterpoint to Hashai and Buckley’s article ‘Is competitive advantage a necessary condition for the emergence of the multinational enterprise?’We agree with their conclusion that it is, in fact, not a necessary condition, but argue that the theoretical reasons behind this are different and more diverse than the ones they propose. We suggest that much extant economic theory is, in fact, consistent with their view that firms may internationalize without owning or achiev...

  8. Semantic integration of scientific publications and research data: proposal of model of expanded publication for the area of nuclear sciences

    International Nuclear Information System (INIS)

    Sales, Luana Farias

    2014-01-01

    applied to the specificity of Nuclear Sciences. This was accomplished in two ways: through a literature review, for purposes of analysis and qualitative interpretation of the general concepts; and through the domain analysis approach that allowed empirically analyze the particular application area. As a final result was obtained a proposal of guidelines for a national policy for digital curation, and a model of scientific publication to the Nuclear Sciences area, in which the research data are linked to the academic publications by means of semantic relations systematized into taxonomy built for this purpose. Graphic models are used as a tool to represent and synthesize the resulting concepts. As a conclusion it is observed: changes in the scholarly communication cycle, the possibility of building a new scientific model as relevant standard to the practice of a more open and more collaborative science, and feasibility of incorporating the principles and theories of librarianship and Information Science for the organization of technical and scientific knowledge in the world of eScience. (author)

  9. Earlier reperfusion in patients with ST-elevation Myocardial infarction by use of helicopter

    Science.gov (United States)

    2012-01-01

    Background In patients with ST-elevation myocardial infarction (STEMI) reperfusion therapy should be initiated as soon as possible. This study evaluated whether use of a helicopter for transportation of patients is associated with earlier initiation of reperfusion therapy. Material and methods A prospective study was conducted, including patients with STEMI and symptom duration less than 12 hours, who had primary percutaneous coronary intervention (PPCI) performed at Aarhus University Hospital in Skejby. Patients with a health care system delay (time from emergency call to first coronary intervention) of more than 360 minutes were excluded. The study period ran from 1.1.2011 until 31.12.2011. A Western Denmark Helicopter Emergency Medical Service (HEMS) project was initiated 1.6.2011 for transportation of patients with time-critical illnesses, including STEMI. Results The study population comprised 398 patients, of whom 376 were transported by ambulance Emergency Medical Service (EMS) and 22 by HEMS. Field-triage directly to the PCI-center was used in 338 of patients. The median system delay was 94 minutes among those field-triaged, and 168 minutes among those initially admitted to a local hospital. Patients transported by EMS and field-triaged were stratified into four groups according to transport distance from the scene of event to the PCI-center: ≤25 km., 26–50 km., 51–75 km. and > 75 km. For these groups, the median system delay was 78, 89, 99, and 141 minutes. Among patients transported by HEMS and field-triaged the estimated median transport distance by ground transportation was 115 km, and the observed system delay was 107 minutes. Based on second order polynomial regression, it was estimated that patients with a transport distance of >60 km to the PCI-center may benefit from helicopter transportation, and that transportation by helicopter is associated with a system delay of less than 120 minutes even at a transport distance up to 150 km

  10. Coping and emotional distress during acute hospitalization in older persons with earlier trauma: the case of Holocaust survivors.

    Science.gov (United States)

    Kimron, Lee; Cohen, Miri

    2012-06-01

    Older persons with earlier trauma are often more vulnerable to stresses of old age. To examine the levels of emotional distress in relation to cognitive appraisal of acute hospitalization and coping strategies in Holocaust survivors compared with an age- and education-matched group of elderly persons without Holocaust experience. This is a cross-sectional study of 63 Holocaust survivors, 65 years and older, hospitalized for an acute illness, and 57 age-, education- and hospital unit-matched people without Holocaust experience. Participants completed appraisal and coping strategies (COPE) questionnaires, and the brief symptoms inventory (BSI-18). Holocaust survivors reported higher levels of emotional distress, appraised the hospitalization higher as a threat and lower as a challenge, and used more emotion-focused and less problem-focused or support-seeking coping strategies than the comparison group. Study variables explained 65% of the variance of emotional distress; significant predictors of emotional distress in the final regression model were not having a partner and more use of emotion-focused coping. The latter mediated the relation of group variable and challenge appraisal to emotional distress. Health professionals must be aware of the potential impact of the hospital environment on the survivors of Holocaust as well as survivors of other trauma. Being sensitive to their specific needs may reduce the negative impact of hospitalization.

  11. Models including electron correlation in relation to Fock's proposed expansion of the ground-state wave function of He-like atomic ions

    Energy Technology Data Exchange (ETDEWEB)

    Glasser, M. L.; March, N. H.; Nieto, L. M. [Departamento de Fisica Teorica, Atomica y Optica, Universidad de Valladolid, ES-47011 Valladolid, Spain and Department of Physics, Clarkson University, Potsdam, New York 13699 (United States); Department of Physics, University of Antwerp, BE-2020 Antwerp, Belgium and Department of Theoretical Chemistry, University of Oxford, Oxford OX1 2JD (United Kingdom); Departamento de Fisica Teorica, Atomica y Optica, Universidad de Valladolid, ES-47011 Valladolid (Spain)

    2011-12-15

    Here attention is first drawn to the importance of gaining insight into Fock's early proposal for expanding the ground-state wave function for He-like atomic ions in hyperspherical coordinates. We approach the problem via two solvable models, namely, (i) the s-term model put forth by Temkin [Phys. Rev. 126, 130 (1962)] and (ii) the Hookean atom model proposed by Kestner and Sinanoglu [Phys. Rev. 128, 2687 (1962)]. In both cases the local kinetic energy can be obtained explicitly in hyperspherical coordinates. Separation of variables occurs in both model wave functions, though in a different context in the two cases. Finally, a k-space formulation is proposed that should eventually result in distinctive identifying characteristics of Fock's nonanalyticities for He-like atomic ions when both electrons are close to the nucleus.

  12. Knowledge Management Implementation at the Women’s Branch of the Institute of Public Administration in Saudi Arabia: A Proposed Model

    Directory of Open Access Journals (Sweden)

    Eiman Saud Abokhodiar

    2014-05-01

    Full Text Available This article aims to introduce a proposed model of knowledge management implementation at the Women’s Branch of the Institute of Public Administration (WIPA. The model was built after a review and analysis of literature related to knowledge management implementation in higher education institutions. The research includes three sections. The first section deals with a theoretical framework of knowledge management, including a knowledge management definition, components of knowledge management systems, an academic knowledge framework, an organizational knowledge framework, and processes of knowledge management. The second section reviews and discusses the proposed model of knowledge management implementation at WIPA. Finally, the article concludes with a discussion of the success factors and expected barriers to the proposed model.

  13. Methodology proposal for the development of Tillage Models - (Part II) Indexes of physical-mechanic characterization of the soil and development of a tillage model

    International Nuclear Information System (INIS)

    Lozano Osorno Fernando; Castillo Herran, Bernardo

    1999-01-01

    A proposal was presented for the elaboration of tillage models that allows making decisions on systems of soil preparation (including the option of zero tillage) starting with measurements of the condition of these. After following a plan of sampling of diverse physical-mechanics parameters of the soil and of a statistical process of correlation, they were chosen as representative variables: the apparent density, the cone index, the content of humidity and the cohesion (torsion box, proves in situ); not only such parameters are very related to each other, but rather they also make possible to estimate other variables of interest like the total porosity appropriately, the macro-porosity, the hydraulic conductivity and in general the soil resistance, which makes viable to choose methods of removal of the soil in function of the initial state of the same one. In the proven case it could verify the possibility to establish systems of tillage reduction

  14. Hydrogeologic modelling in support of a proposed deep geologic repository in Canada for low and intermediate level radioactive waste - 16264

    International Nuclear Information System (INIS)

    Sykes, Jonathan F.; Normani, Stefano D.; Yin, Yong; Sykes, Eric A.; Jensen, Mark R.

    2009-01-01

    A Deep Geologic Repository (DGR) for Low and Intermediate Level radioactive waste has been proposed by Ontario Power Generation for the Bruce Nuclear Power Development site in Ontario, Canada. The DGR is to be constructed at a depth of about 680 m below ground surface within the argillaceous Ordovician limestone of the Cobourg Formation. This paper describes a regional-scale geologic conceptual model for the DGR site and analyzes flow system evolution using the FRAC3DVSOPG flow and transport model. This provides a framework for the assembly and integration of site-specific geo-scientific data that explains and illustrates the factors that influence the predicted long-term performance of the geosphere barrier. In the geologic framework of the Province of Ontario, the Bruce DGR is located at the eastern edge of the Michigan Basin. Borehole logs covering Southern Ontario combined with site specific data have been used to define the structural contours at the regional and site scale of the 31 sedimentary strata that may be present above the Precambrian crystalline basement rock. The regional-scale domain encompasses an 18.500 km 2 region extending from Lake Huron to Georgian Bay. The groundwater zone below the Devonian is characterized by units containing stagnant water having high concentrations of total dissolved solids that can exceed 300 g/l. The computational sequence involves the calculation of steady-state density independent flow that is used as the initial condition for the determination of pseudo-equilibrium for a density dependent flow system that has an initial TDS distribution developed from observed data. Long-term simulations that consider future glaciation scenarios include the impact of ice thickness and permafrost. The selection of the performance measure used to evaluate a groundwater system is important. The traditional metric of average water particle travel time is inappropriate for geologic units such as the Ordovician where solute transport is

  15. Reprint of "A proposed cell model for multiple-occurrence regional landslide events: Implications for landslide susceptibility mapping"

    Science.gov (United States)

    Crozier, M. J.

    2018-04-01

    Multiple-occurrence regional landslide events (MORLEs) consist of hundreds to thousands of shallow landslides occurring more or less simultaneously within defined areas, ranging from tens to thousands of square kilometres. While MORLEs can be triggered by rainstorms and earthquakes, this paper is confined to those landslide events triggered by rainstorms. Globally, MORLEs occur in a range of geological settings in areas of moderate to steep slopes subject to intense rainstorms. Individual landslides in rainstorm-triggered events are dominantly small, shallow debris and earth flows, and debris and earth slides involving regolith or weathered bedrock. The model used to characterise these events assumes that energy distribution within the event area is represented on the land surface by a cell structure; with maximum energy expenditure within an identifiable core and rapid dissipation concentrically away from the centre. The version of the model presented here has been developed for rainfall-triggered landslide events. It proposes that rainfall intensity can be used to determine different critical landslide response zones within the cell (referred to as core, middle, and periphery zones). These zones are most readily distinguished by two conditions: the proportion of the slope that fails and the particular type of the slope stability factor that assumes dominance in determining specific sites of landslide occurrence. The latter condition means that the power of any slope stability factor to distinguish between stable and unstable sites varies throughout the affected area in accordance with the landslide response zones within the cell; certain factors critical for determining the location of landslide sites in one part of the event area have little influence in other parts of the event area. The implication is that landslide susceptibility maps (and subsequently derived mitigation measures) based on conventional slope stability factors may have only limited validity

  16. Capturing the role of awareness and information search processes on Choice Set Formation in Models of Activity-Travel Behavior

    NARCIS (Netherlands)

    Arentze, T.A.; Timmermans, H.J.P.

    2004-01-01

    Individuals choose locations for conducting specific activities generally under limited information conditions and update their mental map during traveling and implementing activities. In an earlier study, we proposed a Bayesian belief network to model an individual's mental map and spatial

  17. Progressively implementation of the new degrees at E.T.S. of Agriculture Engineering and extinction of the earlier degrees

    Science.gov (United States)

    Arce, A.; Caniego, J.; Vazquez, J.; Serrano, A.; Tarquis, A. M.; Cartagena, M. C.

    2012-04-01

    The Bologna process is to improve the quality of education, mobility, diversity and the competitiveness and involves three fundamental changes: transform of the structure of titles, changing in methods of teaching and implementation of the systems of quality assurance. Once that the new degrees have been implemented with this structure, and began at E.T.S. of Agriculture Engineering (ETSIA) at Madrid from 2010-2011 course, the main aim of this work is to deeply study the changes in teaching methodology as well as progressively implementation of the educational planning of the three new degrees: Engineering and Agronomic Graduate, Food Industry Engineering Graduate and Agro-environmental Graduate. Each one of them presents 240 ECTS with a common first course and will have access to an official Master in Agronomic Engineering. As part as an educational innovation project awarded by the Technical University of Madrid (UPM) to improve educational quality, the second course has been designed with the main objective to continue the educative model implemented last course. This model identifies several teaching activities and represents a proper teaching style at ETSIA-UPM. At the same time, a monitoring and development coordination plans have been established. On the other hand, a procedure to extinguish the earlier plans of Agriculture Engineering was also defined. Other activities related to this Project were the information improvement of the grades, in particular at High Schools centers, improving the processes of reception, counseling and tutoring and mentoring. Likewise, cooperative working workshops and programs to support the teaching of English language were implemented. Satisfaction surveys and opinion polls were done to professors and students involved in first course in order to test several aspects of this project. The students surveys were analyzed taking in account the academic results and their participation in mentoring activities giving a highly

  18. Porphyromonas crevioricanis is an earlier heterotypic synonym of Porphyromonas cansulci and has priority.

    Science.gov (United States)

    Sakamoto, Mitsuo; Ohkuma, Moriya

    2013-02-01

    A DNA-DNA hybridization experiment was carried out to clarify the relationship between Porphyromonas crevioricanis and Porphyromonas cansulci. The taxonomic standing of these two species was unclear so far because of the high 16S rRNA gene sequence similarity value (99.9 %). The DNA-DNA relatedness values between P. crevioricanis JCM 15906(T) and P. cansulci JCM 13913(T) were above 91 % (91-99 %). In addition, P. crevioricanis JCM 15906(T) exhibited high hsp60 gene sequence similarity with P. cansulci JCM 13913(T) (100 %). The hsp60 gene sequence analysis and the DNA-DNA relatedness values demonstrated that P. crevioricanis JCM 15906(T) and P. cansulci JCM 13913(T) are a single species. Based on these data, we propose Porphyromonas cansulci as a later heterotypic synonym of Porphyromonas crevioricanis.

  19. Analogy, an Alternative Model.
 Critics to the standard model of analogical problems solving and proposals for an alternative one

    Directory of Open Access Journals (Sweden)

    Ricardo A. Minervino

    2016-02-01

    Full Text Available The authors made an extension of Hofstadter‘s criticisms against the standard approach in analogical thinking represented by the structure-mapping theory of Gentner and the multiconstraint theory of Holyoak and Thagard. Based on this extension, they proposed a non-serial model of analogical problem solving. Against the standard approach, the model postulates that: (a people detect and evaluate differences between mapped elements before the subprocess of inference generation and consider them in order to control it, and (b properties of an element that explain why the element could fill a certain role in the base problem resolution (PERs play a crucial role in these detection and evaluation operations, and also in post-inferences subprocesses. An experiment showed that: (a people detect and evaluate the relevance of differences between mapped elements before inference generation, (b that they inhibit the generation of literal inferences when they face relevant differences, and (c that they stop the subprocess when they recognize insuperable ones. The results also showed that base PERs are reactivated at different moments of analogical transfer. The data obtained are incompatible with the standard theories of analogical thinking, which treat inference generation as a syntactic mechanism and exclude contextual semantic analysis from the study of analogy. 

  20. A proposal for both plasma ion- and electron-temperature diagnostics under simultaneous incidence of particles and x-rays into a semiconductor on the basis of a proposed model for a semiconductor detector response

    International Nuclear Information System (INIS)

    Numakura, T; Cho, T; Kohagura, J; Hirata, M; Minami, R; Yoshida, M; Nakashima, Y; Tamano, T; Yatsu, K; Miyoshi, S

    2003-01-01

    A method is proposed for obtaining radial profiles of plasma temperatures of both plasma ion (T i ) and electron (T e ) simultaneously by the use of a semiconductor detector array. The method is based on our developed particle-response model for a semiconductor detector; in particular, the response theory is constructed for giving the applicability in particle energies ranging down to a kiloelectronvolt. Calculated results from our model are in fairly good agreement with experimental data on the detector response of incident particle beams with energies in the range 100 eV to a few kiloelectronvolts. On the basis of the verification of the proposed model, an idea of the use of a developed semiconductor detector array covered with 'reliably unbreakable' ultrathin SiO 2 'dead-layer filters' having various nanometre-order thicknesses is applied for simultaneous T i and T e analyses by using charge-exchange neutral particles and x-rays from plasmas. Radial profiles of T i and T e are obtained in a single plasma discharge alone, and the data reliability is independently cross-checked by a radial scan of a conventional charge-exchange neutral-particle analyser system as well as a 50-channel microchannel plate x-ray diagnostics system in the GAMMA 10 tandem mirror

  1. Earlier reviews concluded that Seed dormancy is one of the least ...

    African Journals Online (AJOL)

    All Mankind

    2012-11-01

    Nov 1, 2012 ... Effect of temperature is discussed in thermal-time model. (Ellis et al. 1986 ... and hydro parameters) explains the growth of seeds in a better way as ... the time for a given germination percentage tg, and is a constant for that ...

  2. Modeling Unobserved Consideration Sets for Household Panel Data

    NARCIS (Netherlands)

    J.E.M. van Nierop; R. Paap (Richard); B. Bronnenberg; Ph.H.B.F. Franses (Philip Hans)

    2000-01-01

    textabstractWe propose a new method to model consumers' consideration and choice processes. We develop a parsimonious probit type model for consideration and a multinomial probit model for choice, given consideration. Unlike earlier models of consideration ours is not prone to the curse of

  3. The Proposal Concept of Development and Implementation in Strategy of Sustainable Corporate Social Responsibility in the Context of the HCS Model 3E

    Science.gov (United States)

    Sakál, Peter; Hrdinová, Gabriela

    2016-06-01

    This article is the result of a conceptual design methodology for the development of a sustainable strategy of sustainable corporate social responsibility (SCSR) in the context of the HCS model 3E formed, as a co-author within the stated grants and dissertation. On the basis of the use of propositional logic, the SCSR procedure is proposed for incorporation into the corporate strategy of sustainable development and the integrated management system (IMS) of the industrial enterprise. The aim of this article is the proposal of the concept of development and implementation strategy of SCSR in the context of the HCS model 3E.

  4. Thesis Proposal

    DEFF Research Database (Denmark)

    Sloth, Erik

    2010-01-01

    Strukturen i Thesis proposal er følgende: Først præsenteres mine konkrete empiriske forskningsprojekter som skal munde ud i afhandlingens artikler. Jeg præsenterer herefter de teoretiske overvejelser omkring oplevelsesbegrebet og forbrugerkulturteori som danner baggrund for at jeg er nået frem til...

  5. The modeling of contaminant flow during proposed treatment of U.S. Department of Energy low-level radioactive mixed wastes

    International Nuclear Information System (INIS)

    Dolak, D.A.; Wilkins, B.D.; Kotek, T.J.; Wang, Y.Y.; Meshkov, N.K.

    1995-01-01

    Estimations of waste materials throughput and the potential radiological and chemical releases resulting from the proposed treatment of US Department of Energy (DOE) low-level mixed wastes (LLMWs) were used to support analyses of risks and costs associated with various waste management alternatives outlined in the Office of Environmental Management Programmatic Environmental Impact Statement (EM PEIS). The modeling of material flow and contaminant releases through a consolidated waste management flowchart was performed by the WASTE MGMT computational model developed by Argonne National Laboratory. This paper (1) briefly describes the process used to model estimated material and contaminant flow through the proposed treatment scenarios for the EM PEIS, (2) discusses the key site- and/or waste-stream-dependent factors involved in the determination of radiological and chemical emissions, and (3) explains the assumptions used to integrate the available LLMW database with the computational model

  6. Modelling magma-drift interaction at the proposed high-level radioactive waste repository at Yucca Mountain, Nevada, USA

    NARCIS (Netherlands)

    Woods, Andrew W.; Sparks, Steve; Bokhove, Onno; Lejeune, Anne-Marie; Connor, Charles B.; Hill, Britain E.

    2002-01-01

    We examine the possible ascent of alkali basalt magma containing 2 wt percent water through a dike and into a horizontal subsurface drift as part of a risk assessment for the proposed high-level radioactive waste repository beneath Yucca Mountain, Nevada, USA. On intersection of the dike with the

  7. Meeting the Needs of Chinese English Language Learners at Writing Centers in America: A Proposed Culturally Responsive Model

    Science.gov (United States)

    Wang, Peizhen; Machado, Crystal

    2015-01-01

    This paper describes the ways in which Writing Centers (WC) currently serve English Language Learners (ELL) at American universities. The authors argue that the pedagogy offered at these centers does not always meet the needs of the Chinese ELLs who make up the largest population of ELLs at American universities. The proposed supplemental model…

  8. Collaborative Proposal: Improving Decadal Prediction of Arctic Climate Variability and Change Using a Regional Arctic System Model (RASM)

    Energy Technology Data Exchange (ETDEWEB)

    Maslowski, Wieslaw [Naval Postgraduate School, Monterey, CA (United States). Dept. of Oceanography; Cassano, John J. [Univ. of Colorado, Boulder, CO (United States); Gutowski, Jr., William J. [Iowa State Univ., Ames, IA (United States); Lipscomb, William H. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Nijssen, Bart [Univ. of Washington, Seattle, WA (United States); Roberts, Andrew [Naval Postgraduate School, Monterey, CA (United States). Dept. of Oceanography; Robertson, William [Univ. of Texas, El Paso, TX (United States); Tulaczyk, Slawek [Univ. of California, Santa Cruz, CA (United States); Zeng, Xubin [Univ. of Arizona, Tucson, AZ (United States)

    2011-05-15

    The primary outcome of the project was the development of the Regional Arctic System Model (RASM) and evaluation of its individual model components, coupling among them and fully coupled model results. Overall, we have demonstrated that RASM produces realistic mean and seasonal surface climate as well as its interannual and decadal variability and trends.

  9. Engaging Struggling Adolescent Readers through Situational Interest: A Model Proposing the Relationships among Extrinsic Motivation, Oral Reading Proficiency, Comprehension, and Academic Achievement

    Science.gov (United States)

    Paige, David D.

    2011-01-01

    Reading ability and motivation among adolescents across the country continues to be problematic, as only slightly more than one-third read at a proficient level (Grigg, Donahue, & Dion, 2007; Unrau & Schlackman, 2006). Hidi and Renninger (2006) have proposed a four-phase model of situational interest that suggests how activities involving…

  10. Proposal for a Revised Programme of Studies at the Faculty of Engineering, Ondo State University Using the Pedagogical Model at AUC as Reference

    DEFF Research Database (Denmark)

    Jørgensen, Mogens B.; Borch, Ole; Esan, A. A.

    by AUC Staff. It will, of course, remain a requirement that minimum requirements laid down by the National Universities Commission are met. This was taken into account when preparing the proposal. The report is seen as a first important step towards the introduction of the AUC pedagogical model at OSUA...

  11. Real external predictivity of QSAR models: how to evaluate it? Comparison of different validation criteria and proposal of using the concordance correlation coefficient.

    Science.gov (United States)

    Chirico, Nicola; Gramatica, Paola

    2011-09-26

    The main utility of QSAR models is their ability to predict activities/properties for new chemicals, and this external prediction ability is evaluated by means of various validation criteria. As a measure for such evaluation the OECD guidelines have proposed the predictive squared correlation coefficient Q(2)(F1) (Shi et al.). However, other validation criteria have been proposed by other authors: the Golbraikh-Tropsha method, r(2)(m) (Roy), Q(2)(F2) (Schüürmann et al.), Q(2)(F3) (Consonni et al.). In QSAR studies these measures are usually in accordance, though this is not always the case, thus doubts can arise when contradictory results are obtained. It is likely that none of the aforementioned criteria is the best in every situation, so a comparative study using simulated data sets is proposed here, using threshold values suggested by the proponents or those widely used in QSAR modeling. In addition, a different and simple external validation measure, the concordance correlation coefficient (CCC), is proposed and compared with other criteria. Huge data sets were used to study the general behavior of validation measures, and the concordance correlation coefficient was shown to be the most restrictive. On using simulated data sets of a more realistic size, it was found that CCC was broadly in agreement, about 96% of the time, with other validation measures in accepting models as predictive, and in almost all the examples it was the most precautionary. The proposed concordance correlation coefficient also works well on real data sets, where it seems to be more stable, and helps in making decisions when the validation measures are in conflict. Since it is conceptually simple, and given its stability and restrictiveness, we propose the concordance correlation coefficient as a complementary, or alternative, more prudent measure of a QSAR model to be externally predictive.

  12. A study on an efficient prediction of welding deformation for T-joint laser welding of sandwich panel PART I : Proposal of a heat source model

    Directory of Open Access Journals (Sweden)

    Jae Woong Kim

    2013-09-01

    Full Text Available The use of I-Core sandwich panel has increased in cruise ship deck structure since it can provide similar bending strength with conventional stiffened plate while keeping lighter weight and lower web height. However, due to its thin plate thickness, i.e. about 4~6 mm at most, it is assembled by high power CO2 laser welding to minimize the welding deformation. This research proposes a volumetric heat source model for T-joint of the I-Core sandwich panel and a method to use shell element model for a thermal elasto-plastic analysis to predict welding deformation. This paper, Part I, focuses on the heat source model. A circular cone type heat source model is newly suggested in heat transfer analysis to realize similar melting zone with that observed in experiment. An additional suggestion is made to consider negative defocus, which is commonly applied in T-joint laser welding since it can provide deeper penetration than zero defocus. The proposed heat source is also verified through 3D thermal elasto-plastic analysis to compare welding deformation with experimental results. A parametric study for different welding speeds, defocus values, and welding powers is performed to investigate the effect on the melting zone and welding deformation. In Part II, focuses on the proposed method to employ shell element model to predict welding deformation in thermal elasto-plastic analysis instead of solid element model.

  13. Holistic self-management education and support: a proposed public health model for improving women's health in Zimbabwe.

    Science.gov (United States)

    Kanchense, Jane Handina Murigwa

    2006-08-01

    The primary health care model of public health has been implemented in many countries around the globe since the Declaration of Alma Ata in 1978, without pilot testing the primary health care model. Therefore, many public health researchers have sought methods of improving primary health care by creating evidence-based models. Many of these researchers recognize the role of behavioral models in public health. These offshoots of primary health care include the ecological, care, central human capabilities, and the SPECIES models. Holistic self-management education and support is a capacity-building philosophy that ensures active involvement of consumers of health care in the planning and implementation and evaluation of health care services. It helps consumers of health care to achieve the desired improved quality of health and life in managing and sustaining their health at the grassroots level. The care model addresses disease management ideals of the in the original primary health care model. The SPECIES model addresses those aspects of the primary health care model that include the cultural and social factors, as well as individual health education and support in the original primary health care model. The ecological model offers an improvement of the socioeconomic ideal in the original primary health care model. Improving the health of individuals will prevent illness, thereby reducing health care costs and lessening the current strain on an overburdened health care system in Zimbabwe. Holistic self-management education and support links health care delivery systems with social processes. It is a best practices model that could better serve Zimbabwean girls and women by contributing positively to the national challenges in health care, thereby meeting the Zimbabwean primary health care and safe motherhood goals. It is here recommended that holistic self-management education and support must be pilot tested before being adopted as the most appropriate model for

  14. An earlier time of scan is associated with greater threat-related amygdala reactivity.

    Science.gov (United States)

    Baranger, David A A; Margolis, Seth; Hariri, Ahmad R; Bogdan, Ryan

    2017-08-01

    Time-dependent variability in mood and anxiety suggest that related neural phenotypes, such as threat-related amygdala reactivity, may also follow a diurnal pattern. Here, using data from 1,043 young adult volunteers, we found that threat-related amygdala reactivity was negatively coupled with time of day, an effect which was stronger in the left hemisphere (β = -0.1083, p-fdr = 0.0012). This effect was moderated by subjective sleep quality (β = -0.0715, p-fdr = 0.0387); participants who reported average and poor sleep quality had relatively increased left amygdala reactivity in the morning. Bootstrapped simulations suggest that similar cross-sectional samples with at least 300 participants would be able to detect associations between amygdala reactivity and time of scan. In control analyses, we found no associations between time and V1 activation. Our results provide initial evidence that threat-related amygdala reactivity may vary diurnally, and that this effect is potentiated among individuals with average to low sleep quality. More broadly, our results suggest that considering time of scan in study design or modeling time of scan in analyses, as well as collecting additional measures of circadian variation, may be useful for understanding threat-related neural phenotypes and their associations with behavior, such as fear conditioning, mood and anxiety symptoms, and related phenotypes. © The Author (2017). Published by Oxford University Press.

  15. Adolescent internalizing symptoms and negative life events: the sensitizing effects of earlier life stress and cortisol.

    Science.gov (United States)

    Ruttle, Paula L; Armstrong, Jeffrey M; Klein, Marjorie H; Essex, Marilyn J

    2014-11-01

    Although adolescence is marked by increased negative life events and internalizing problems, few studies investigate this association as an ongoing longitudinal process. Moreover, while there are considerable individual differences in the degree to which these phenomena are linked, little is known about the origins of these differences. The present study examines early life stress (ELS) exposure and early-adolescent longitudinal afternoon cortisol level as predictors of the covariation between internalizing symptoms and negative life events across high school. ELS was assessed by maternal report during infancy, and the measure of cortisol was derived from assessments at ages 11, 13, and 15 years. Life events and internalizing symptoms were assessed at ages 15, 17, and 18 years. A two-level hierarchical linear model revealed that ELS and cortisol were independent predictors of the covariation of internalizing symptoms and negative life events. Compared to those with lower levels of ELS, ELS-exposed adolescents displayed tighter covariation between internalizing symptoms and negative life events. Adolescents with lower longitudinal afternoon cortisol displayed tighter covariation between negative life events and internalizing symptoms, while those with higher cortisol demonstrated weaker covariation, partially due to increased levels of internalizing symptoms when faced with fewer negative life events.

  16. Distribution of stoneflies of the family Taeniopterygidae (Plecoptera) in the Czech Republic: earlier data, new records and recent distributional changes

    Czech Academy of Sciences Publication Activity Database

    Bojková, J.; Soldán, Tomáš; Špaček, J.; Straka, M.

    2011-01-01

    Roč. 60, č. 3 (2011), s. 239-258 ISSN 1211-3026 Grant - others:Czech Science Foundation(CZ) GAP505/10/P302 Program:GP Institutional research plan: CEZ:AV0Z50070508 Keywords : Plecoptera * Taeniopterygidae * historical and earlier data Subject RIV: EH - Ecology, Behaviour

  17. Are cause of subfertility and in vitro fertilization treatment risk factors for an earlier start of menopauze?

    NARCIS (Netherlands)

    de Boer, E.J.; den Tonkelaar, I.; Burger, C.W.; van Leeuwen, F.E.

    2005-01-01

    Objective: To study whether women diagnosed with unexplained subfertility reach the menopause transition and natural menopause earlier than women with tubal subfertility, in an in vitro fertilization (FVF)-treated population, and to examine the influence of the number of FVT cycles on the occurrence

  18. Natural selection for earlier male arrival to breeding grounds through direct and indirect effects in a migratory songbird

    NARCIS (Netherlands)

    Velmala, William; Helle, Samuli; Ahola, Markus P.; Klaassen, M.R.J.; Lehikoinen, Esa; Rainio, Kalle; Sirkia, Paivi M.; Laaksonen, Toni

    2015-01-01

    For migratory birds, the earlier arrival of males to breeding grounds is often expected to have fitness benefits. However, the selection differential on male arrival time has rarely been decomposed into the direct effect of male arrival and potential indirect effects through female traits. We

  19. Overweight or obese BMI is associated with earlier, but not later survival after common acute illnesses.

    Science.gov (United States)

    Prescott, Hallie C; Chang, Virginia W

    2018-02-06

    Obesity has been associated with improved short-term mortality following common acute illness, but its relationship with longer-term mortality is unknown. Observational study of U.S. Health and Retirement Study (HRS) participants with federal health insurance (fee-for-service Medicare) coverage, hospitalized with congestive heart failure (N = 4287), pneumonia (N = 4182), or acute myocardial infarction (N = 2001), 1996-2012. Using cox proportional hazards models, we examined the association between overweight or obese BMI (BMI ≥ 25.0 kg/m 2 ) and mortality to 5 years after hospital admission, adjusted for potential confounders measured at the same time as BMI, including age, race, sex, education, partnership status, income, wealth, and smoking status. Body mass index (BMI) was calculated from self-reported height and weight collected at the HRS survey prior to hospitalization (a median 1.1 year prior to hospitalization). The referent group was patients with a normal BMI (18.5 to BMI was associated with lower mortality at 1 year after hospitalization for congestive heart failure, pneumonia, and acute myocardial infarction-with adjusted hazard ratios of 0.68 (95% CI 0.59-0.79), 0.74 (95% CI: 0.64-0.84), and 0.65 (95%CI: 0.53-0.80), respectively. Among participants who lived to one year, however, subsequent survival was similar between patients with normal versus overweight/obese BMI. In older Americans, overweight or obese BMI was associated with improved survival following hospitalization for congestive heart failure, pneumonia, and acute myocardial infarction. This association, however, is limited to the shorter-term. Conditional on surviving to one year, we did not observe a survival advantage associated with excess weight.

  20. Spatial and Temporal Variation in Primary Productivity (NDVI) of Coastal Alaskan Tundra: Decreased Vegetation Growth Following Earlier Snowmelt

    Science.gov (United States)

    Gamon, John A.; Huemmrich, K. Fred; Stone, Robert S.; Tweedie, Craig E.

    2015-01-01

    In the Arctic, earlier snowmelt and longer growing seasons due to warming have been hypothesized to increase vegetation productivity. Using the Normalized Difference Vegetation Index (NDVI) from both field and satellite measurements as an indicator of vegetation phenology and productivity, we monitored spatial and temporal patterns of vegetation growth for a coastal wet sedge tundra site near Barrow, Alaska over three growing seasons (2000-2002). Contrary to expectation, earlier snowmelt did not lead to increased productivity. Instead, productivity was associated primarily with precipitation and soil moisture, and secondarily with growing degree days, which, during this period, led to reduced growth in years with earlier snowmelt. Additional moisture effects on productivity and species distribution, operating over a longer time scale, were evident in spatial NDVI patterns associated with microtopography. Lower, wetter regions dominated by graminoids were more productive than higher, drier locations having a higher percentage of lichens and mosses, despite the earlier snowmelt at the more elevated sites. These results call into question the oft-stated hypothesis that earlier arctic growing seasons will lead to greater vegetation productivity. Rather, they agree with an emerging body of evidence from recent field studies indicating that early-season, local environmental conditions, notably moisture and temperature, are primary factors determining arctic vegetation productivity. For this coastal arctic site, early growing season conditions are strongly influenced by microtopography, hydrology, and regional sea ice dynamics, and may not be easily predicted from snowmelt date or seasonal average air temperatures alone. Our comparison of field to satellite NDVI also highlights the value of in-situ monitoring of actual vegetation responses using field optical sampling to obtain detailed information on surface conditions not possible from satellite observations alone.

  1. The rat as a model for orthodontic tooth movement--a critical review and a proposed solution

    NARCIS (Netherlands)

    Ren, Yijin; Maltha, Jaap C; Kuijpers-Jagtman, Anne Marie

    2004-01-01

    The aims of this study were to perform a systematic review of the use of rats as a model for experimental tooth movement, to give a critical evaluation of the use of elastics as a force delivery system, and to describe a newly designed well-defined model for tooth movement in rats. The literature

  2. Development of a 3-dimensional calculation model of the Danish research reactor DR3 to analyse a proposal to a new core design called ring-core

    Energy Technology Data Exchange (ETDEWEB)

    Nonboel, E

    1985-07-01

    A 3-dimensional calculation model of the Danish research reactor DR3 has been developed. Demands of a more effective utilization of the reactor and its facilities has required a more detailed calculation tool than applied so far. A great deal of attention has been devoted to the treatment of the coarse control arms. The model has been tested against measurements with satisfying results. Furthermore the model has been used to analyse a proposal to a new core design called ring-core where 4 central fuel elements are replaced by 4 dummy elements to increase the thermal flux in the center of the reactor. (author)

  3. Proposed method of the modeling and simulation of corrosion product behavior in the primary cooling system of fast breeder reactors

    International Nuclear Information System (INIS)

    Matuo, Youichirou; Miyahara, Shinya; Izumi, Yoshinobu

    2011-01-01

    Radioactive corrosion products (CP) are main cause of personal radiation exposure during maintenance without fuel failure in FBR plants. In order to establish the techniques of radiation dose estimation for worker in radiation-controlled area, Program SYstem for Corrosion Hazard Evaluation code 'PSYCHE' has been developed. The PSYCHE is based on the Solution-Precipitation model. The CP transfer calculation using the Solution-Precipitation model needs a fitting factor for the calculation of the precipitation of CP. This fitting factor must be determined based on the measured values in reactors that have operating experience. For this reason, the inability to make accurate predictions for reactor without measured values is a major issue. In this study, in addition to existing Solution-Precipitation model in PSYCHE, a transfer-model of CP species in particle form was applied to calculations of CP behavior in the primary cooling system of fast breeder reactor MONJU. Based on the calculated results, we estimated the contribution of CP deposition in the particle-form. It was suggested that the improved model including transfer-model of CP species in particle-form could be used for evaluation of CP transfer and radiation-source distribution in place of conventional Solution-Precipitation model with fitting factor in the PSYCHE. Moreover, it was predicted that CP particles would tend to be deposited in region with high-flow rate of coolant. (author)

  4. Modeling and Proposed Molecular Mechanism of Hydroxyurea Through Docking and Molecular Dynamic Simulation to Curtail the Action of Ribonucleotide Reductase.

    Science.gov (United States)

    Iman, Maryam; Khansefid, Zeynab; Davood, Asghar

    2016-01-01

    Ribonucleotide Reductase (RNR) is an important anticancer chemotherapy target. It has main key role in DNA synthesis and cell growth. Therefore several RNR inhibitors, such as hydroxyurea, have entered the clinical trials. Based on our proposed mechanism, radical site of RNR protein reacts with hydroxyurea in which hydroxyurea is converted into its oxidized form compound III, and whereby the tyrosyl radical is converted into a normal tyrosine residue. In this study, docking and molecular dynamics simulations were used for proposed molecular mechanism of hydroxyurea in RNR inhibition as anticancer agent. The binding affinity of hydroxyurea and compound III to RNR was studied by docking method. The docking study was performed for the crystal structure of human RNR with the radical scavenger Hydroxyurea and its oxidized form to inhibit the human RNR. hydroxyurea and compound III bind at the active site with Tyr-176, which are essential for free radical formation. This helps to understand the functional aspects and also aids in the development of novel inhibitors for the human RNR2. To confirm the binding mode of inhibitors, the molecular dynamics (MD) simulations were performed using GROMACS 4.5.5, based upon the docked conformation of inhibitors. Both of the studied compounds stayed in the active site. The results of MD simulations confirmed the binding mode of ligands, accuracy of docking and the reliability of active conformations which were obtained by AutoDock. MD studies confirm our proposed mechanism in which compound III reacts with the active site residues specially Tyr-176, and inhibits the radical generation and subsequently inhibits the RNR enzyme.

  5. What is the physical meaning of mass in view of wave-particle duality? A proposed model

    OpenAIRE

    Chang, Donald C.

    2004-01-01

    Mass is an important concept in classical mechanics, which regards a particle as a corpuscular object. But according to wave-particle duality, we know a free particle can behave like a wave. Is there a wave property that corresponds to the mass of a particle? This is an interesting question that has not been extensively explored before. We suggest that this problem can be approached by treating the mass on the same footing as energy and momentum. Here we propose that, all particles are excita...

  6. Paying for quality not quantity: a wisconsin health maintenance organization proposes an incentive model for reimbursement of chiropractic services.

    Science.gov (United States)

    Pursel, Kevin J; Jacobson, Martin; Stephenson, Kathy

    2012-07-01

    The purpose of this study is to describe a reimbursement model that was developed by one Health Maintenance Organization (HMO) to transition from fee-for-service to add a combination of pay for performance and reporting model of reimbursement for chiropractic care. The previous incentive program used by the HMO provided best-practice education and additional reimbursement incentives for achieving the National Committee for Quality Assurance Back Pain Recognition Program (NCQA-BPRP) recognition status. However, this model had not leveled costs between doctors of chiropractic (DCs). Therefore, the HMO management aimed to develop a reimbursement model to incentivize providers to embrace existing best-practice models and report existing quality metrics. The development goals included the following: it should (1) be as financially predictable as the previous system, (2) cost no more on a per-member basis, (3) meet the coverage needs of its members, and (4) be able to be operationalized. The model should also reward DCs who embraced best practices with compensation, not simply tied to providing more procedures, the new program needed to (1) cause little or no disruption in current billing, (2) be grounded achievable and defined expectations for improvement in quality, and (3) be voluntary, without being unduly punitive, should the DC choose not to participate in the program. The generated model was named the Comprehensive Chiropractic Quality Reimbursement Methodology (CCQRM; pronounced "Quorum"). In this hybrid model, additional reimbursement, beyond pay-for-procedures will be based on unique payment interpretations reporting selected, existing Physician Quality Reporting System (PQRS) codes, meaningful use of electronic health records, and achieving NCQA-BPRP recognition. This model aims to compensate providers using pay-for-performance, pay-for-quality reporting, pay-for-procedure methods. The CCQRM reimbursement model was developed to address the current needs of one

  7. Model outputs for each hotspot site to identify the likely environmental, economic and social effects of proposed remediation strategies

    DEFF Research Database (Denmark)

    Fleskens, Luuk; Irvine, Brian; Kirkby, Mike

    2012-01-01

    Portuguese sites) a fire severity index under current conditions and under different technologies. The DESMICE model is informed by WB3 WOCAT database records, economic WB4 experimental results, additionally requested data on spatial variability of costs and benefits, and secondary data. It applies spatially...... multiple stakeholders in very different contexts into the modelling process, in order to enhance both the realism and relevance of outputs for policy and practice; b) site-selection modelling is being applied to land degradation mitigation to enable landscape-scale assessments of the most economically....... Biophysical models (e.g. PESERA) should be able to separate immediate and gradual aspects. Ongoing degradation in the without case is not yet implicitly considered. Analysis of robustness to climatic variability and prices is also essential. Finally, factors such as attitude towards conservation and risk...

  8. Scoring of Decomposition: A Proposed Amendment to the Method When Using a Pig Model for Human Studies.

    Science.gov (United States)

    Keough, Natalie; Myburgh, Jolandie; Steyn, Maryna

    2017-07-01

    Decomposition studies often use pigs as proxies for human cadavers. However, differences in decomposition sequences/rates relative to humans have not been scientifically examined. Descriptions of five main decomposition stages (humans) were developed and refined by Galloway and later by Megyesi. However, whether these changes/processes are alike in pigs is unclear. Any differences can have significant effects when pig models are used for human PMI estimation. This study compared human decomposition models to the changes observed in pigs. Twenty pigs (50-90 kg) were decomposed over five months and decompositional features recorded. Total body scores (TBS) were calculated. Significant differences were observed during early decomposition between pigs and humans. An amended scoring system to be used in future studies was developed. Standards for PMI estimation derived from porcine models may not directly apply to humans and may need adjustment. Porcine models, however, remain valuable to study variables influencing decomposition. © 2016 American Academy of Forensic Sciences.

  9. Proposal and experimental validation of analytical models for seismic and vibration isolation devices in nuclear and non-nuclear facilities

    International Nuclear Information System (INIS)

    Serino, G.; Bonacina, G.; Bettinali, F.

    1993-01-01

    Two analytical-experimental models of HDLRBs having different levels of approximations are presented. Comparison with available experimental data shows that a non-linear hysteretic model, defined by three rubber parameters only, allows a very good complete simulation of the dynamic behavior of the isolation devices. A simpler equivalent linear viscous model reproduces less exactly the experimental behavior, but permits a good prediction of peak response values in the earthquake analysis of an isolated structure, if bearing stiffness and damping parameters are properly selected. The models have been used in preliminary design and subsequent check of the isolation system of two different types of Gas-Insulated Electric Substations (GIS), in view of possible future installation of isolated GISes in areas of high seismic risk. (author)

  10. Preliminary proposal of a Nb3Sn quadrupole model for the low β insertions of the LHC

    International Nuclear Information System (INIS)

    Ambrosio, G.; Ametrano, F.; Bellomo, G.; Broggi, F.; Rossi, L.; Volpini, G.

    1995-09-01

    In recent years Nb 3 Sn based conductors have shown wide applicability for superconducting magnets in many research areas like high field solenoids for laboratory experiment, for NMR spectroscopy and high field magnets for fusion. Nb 3 Sn technology is progressing fast, increasing both technical reliability and availability. The Nb 3 Sn technology, which has a higher critical field than NbTi, seems attractive for IR (Insertion Region) quadrupoles of large colliders . In this paper it is proposed the construction of a superconducting quadrupole wound with Nb 3 Sn cable for a second generation IR inner triplet low β quadrupoles, for the Large Hadron Collider at CERN. The low β quadrupoles, control the beam focusing at collision points, therefore a gain in term of focus strength and/or coil aperture can increase significantly machine performance. Two are the main steps for the whole project: 1) design and construction of a 1 metre long quadrupole to demonstrate the actual feasibility, which is the subject of this proposal; 2) study for integration of the quadrupole in the machine and final design of 5 m long quadrupoles finalized to the LHC

  11. Preliminary proposal of a Nb{sub 3}Sn quadrupole model for the low {beta} insertions of the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosio, G; Ametrano, F; Bellomo, G; Broggi, F; Rossi, L; Volpini, G [Milan Univ. (Italy). Dip. di Fisica; [INFN, Sezione di Milano (Italy). Laboratorio Acceleratori e Superconduttivita` Applicata

    1995-09-01

    In recent years Nb{sub 3}Sn based conductors have shown wide applicability for superconducting magnets in many research areas like high field solenoids for laboratory experiment, for NMR spectroscopy and high field magnets for fusion. Nb{sub 3}Sn technology is progressing fast, increasing both technical reliability and availability. The Nb{sub 3}Sn technology, which has a higher critical field than NbTi, seems attractive for IR (Insertion Region) quadrupoles of large colliders . In this paper it is proposed the construction of a superconducting quadrupole wound with Nb{sub 3}Sn cable for a second generation IR inner triplet low {beta} quadrupoles, for the Large Hadron Collider at CERN. The low {beta} quadrupoles, control the beam focusing at collision points, therefore a gain in term of focus strength and/or coil aperture can increase significantly machine performance. Two are the main steps for the whole project: (1) design and construction of a 1 metre long quadrupole to demonstrate the actual feasibility, which is the subject of this proposal; (2) study for integration of the quadrupole in the machine and final design of 5 m long quadrupoles finalized to the LHC.

  12. Information-sharing to promote informed choice in prenatal screening in the spirit of the SOGC clinical practice guideline: a proposal for an alternative model.

    Science.gov (United States)

    Vanstone, Meredith; Kinsella, Elizabeth Anne; Nisker, Jeff

    2012-03-01

    The 2011 SOGC clinical practice guideline "Prenatal Screening for Fetal Aneuploidy in Singleton Pregnancies" recommends that clinicians offer prenatal screening to all pregnant women and provide counselling in a non-directive manner. Non-directive counselling is intended to facilitate autonomous decision-making and remove the clinician's views regarding a particular course of action. However, recent research in genetic counselling raises concerns that non-directive counselling is neither possible nor desirable, and that it may not be the best way to facilitate informed choice. We propose an alternative model of information-sharing specific to prenatal screening that combines attributes of the models of informative decision-making and shared decision-making. Our proposed model is intended to provide clinicians with a strategy to communicate information about prenatal screening in a way that facilitates a shared deliberative process and autonomous decision-making. Our proposed model may better prepare a pregnant woman to make an informed choice about participating in prenatal screening on the basis of her consideration of the medical information provided by her clinician and her particular circumstances and values.

  13. A proposal of constitutive creep model for soft rock to be applied to numerical analysis for mechanical interaction in the underground facilities

    International Nuclear Information System (INIS)

    Sawada, Masataka; Okada, Tetsuji

    2005-01-01

    In the case that the underground facilities of high-level nuclear waste disposal are constructed in soft rock mass, it is predicted that time-dependent behavior of rock has an important role both on the stability of surrounding rock mass after excavation and on the super long-term stability of barrier system. Existing creep model that has been applied to excavation problems in electric power industry is not sufficient in order to evaluate long-term behavior of the facility constructed in soft rock mass. Therefore, it is necessary to develop an appropriate creep model for soft rock. In this research, we try to develop a prototype of numerical tool for evaluating the stability during and after the excavation and super long-term stability after back-filling. Firstly, a simple rheological model for time-dependent behavior of soft rock is proposed. It is the key feature of this model that two different types of rheological model can be selected in order to describe both failure and non-failure processes. Rock continues to deform until failure in the case where stress applied to the rock exceeds its residual strength, although deformation of the rock finally ceases in the other cases. The applicability of this model is investigated by comparing the calculated results with those in laboratory test results. The proposed model can describe the time-dependent and dilatancy behavior of mudstone of Tertiary period observed in the drained triaxial creep test. Next, we apply the proposed model to the problem of time-dependent behavior of rock mass around a deposition hole. Numerical simulation of excavation problem and long-term mechanical interaction between buffer material and surrounding rock mass is carried out using a hydrological - mechanical coupled FEM code that includes the proposed model. Several mechanical models can be selected in order to apply to the mechanical behavior of materials consisting of underground facility. The main results obtained from this simulation

  14. Reconstruction of middle-west Pangaea in and around Mediterranean Sea : A proposal of Pangaea model A3

    Science.gov (United States)

    Kwon, O.-hyeok; Cheong, Hyeong-Bin

    2017-04-01

    In this study, we examined the formation process of Pangaea during the period from mid-Paleozoic to early Mesozoic (300myr-200myr), and reconstructed the Pangaea from a new point of view. The reconstruction of Pangaea on the globe was performed in more elaborate way using the software G-plate than the related, previous study, by trying to put the landmass pieces together with accuracy in and around the Mediterranean Sea: We shall refer to this as Pangaea A3 model. Following the A3 model, the Pangaea seems to have been formed by the collision of Laurasia and the Gondwana. At that time the Pangaea existed as a huge landmass exclusive of the Siberia without any inland sea. However, the Laurasia broke out of the Gondwana soon after the formation. During the separation process it made an anticlockwise rotation with respect to the Gondwana. At this time, the South America also separated from the Africa, which made anticlockwise rotation, too. Until now, the Pangaea has been known to be represented as so-called C-shape. In this model the gap between the Gondwana and Laurasia becomes broader toward the east and the Tethys sea existed between them. While being in good agreement with the C-shape model, the present Pangaea model explains its formation process. One distinction between the two models is that the Tethys sea in the present model is narrower than that in the C-shape model, and it consists of a long waterway and large circular inland-sea (marine crust). The Pangaea did not undergo significant change between 300 myr and 200 myr except that the Cimmeria blocks, which were originally located in the northern edge of the continent, broke away and finally collided to the Laurasia in the course of northward drifting. New findings in the present study are believed to have improved the understanding of the Pangaea over the previous studies. The results may be summarized as follows. Firstly, the Pangaea A3 model exhibits almost complete fit of continents and landmasses

  15. Full-field and anomaly initialization using a low-order climate model: a comparison and proposals for advanced formulations

    Science.gov (United States)

    Carrassi, A.; Weber, R. J. T.; Guemas, V.; Doblas-Reyes, F. J.; Asif, M.; Volpi, D.

    2014-04-01

    Initialization techniques for seasonal-to-decadal climate predictions fall into two main categories; namely full-field initialization (FFI) and anomaly initialization (AI). In the FFI case the initial model state is replaced by the best possible available estimate of the real state. By doing so the initial error is efficiently reduced but, due to the unavoidable presence of model deficiencies, once the model is let free to run a prediction, its trajectory drifts away from the observations no matter how small the initial error is. This problem is partly overcome with AI where the aim is to forecast future anomalies by assimilating observed anomalies on an estimate of the model climate. The large variety of experimental setups, models and observational networks adopted worldwide make it difficult to draw firm conclusions on the respective advantages and drawbacks of FFI and AI, or to identify distinctive lines for improvement. The lack of a unified mathematical framework adds an additional difficulty toward the design of adequate initialization strategies that fit the desired forecast horizon, observational network and model at hand. Here we compare FFI and AI using a low-order climate model of nine ordinary differential equations and use the notation and concepts of data assimilation theory to highlight their error scaling properties. This analysis suggests better performances using FFI when a good observational network is available and reveals the direct relation of its skill with the observational accuracy. The skill of AI appears, however, mostly related to the model quality and clear increases of skill can only be expected in coincidence with model upgrades. We have compared FFI and AI in experiments in which either the full system or the atmosphere and ocean were independently initialized. In the former case FFI shows better and longer-lasting improvements, with skillful predictions until month 30. In the initialization of single compartments, the best

  16. Collaborative Proposal: Improving Decadal Prediction of Arctic Climate Variability and Change Using a Regional Arctic System Model (RASM)

    Energy Technology Data Exchange (ETDEWEB)

    Maslowski, Wieslaw [Naval Postgraduate School, Monterey, CA (United States)

    2016-10-17

    This project aims to develop, apply and evaluate a regional Arctic System model (RASM) for enhanced decadal predictions. Its overarching goal is to advance understanding of the past and present states of arctic climate and to facilitate improvements in seasonal to decadal predictions. In particular, it will focus on variability and long-term change of energy and freshwater flows through the arctic climate system. The project will also address modes of natural climate variability as well as extreme and rapid climate change in a region of the Earth that is: (i) a key indicator of the state of global climate through polar amplification and (ii) which is undergoing environmental transitions not seen in instrumental records. RASM will readily allow the addition of other earth system components, such as ecosystem or biochemistry models, thus allowing it to facilitate studies of climate impacts (e.g., droughts and fires) and of ecosystem adaptations to these impacts. As such, RASM is expected to become a foundation for more complete Arctic System models and part of a model hierarchy important for improving climate modeling and predictions.

  17. To achieve an earlier IFN-γ response is not sufficient to control Mycobacterium tuberculosis infection in mice.

    Science.gov (United States)

    Vilaplana, Cristina; Prats, Clara; Marzo, Elena; Barril, Carles; Vegué, Marina; Diaz, Jorge; Valls, Joaquim; López, Daniel; Cardona, Pere-Joan

    2014-01-01

    The temporo-spatial relationship between the three organs (lung, spleen and lymph node) involved during the initial stages of Mycobacterium tuberculosis infection has been poorly studied. As such, we performed an experimental study to evaluate the bacillary load in each organ after aerosol or intravenous infection and developed a mathematical approach using the data obtained in order to extract conclusions. The results showed that higher bacillary doses result in an earlier IFN-γ response, that a certain bacillary load (BL) needs to be reached to trigger the IFN-γ response, and that control of the BL is not immediate after onset of the IFN-γ response, which might be a consequence of the spatial dimension. This study may have an important impact when it comes to designing new vaccine candidates as it suggests that triggering an earlier IFN-γ response might not guarantee good infection control, and therefore that additional properties should be considered for these candidates.

  18. An inhibitor of polyamine synthesis arrests cells at an earlier stage of G1 than does calcium deprivation.

    OpenAIRE

    Cheetham, B F

    1983-01-01

    Methylglyoxal bis(guanylhydrazone) completely inhibits the induction of thymidine kinase after serum stimulation of quiescent fibroblasts only if added within 3 h after serum, whereas calcium deprivation blocks this induction up to 12 h after serum stimulation. Experiments in which one of these blocks was imposed as the other was released confirmed that cells blocked by methylglyoxal bis(guanylhydrazone) are arrested at an earlier stage in G1 than cells blocked by calcium deprivation.

  19. An inhibitor of polyamine synthesis arrests cells at an earlier stage of G1 than does calcium deprivation.

    Science.gov (United States)

    Cheetham, B F

    1983-01-01

    Methylglyoxal bis(guanylhydrazone) completely inhibits the induction of thymidine kinase after serum stimulation of quiescent fibroblasts only if added within 3 h after serum, whereas calcium deprivation blocks this induction up to 12 h after serum stimulation. Experiments in which one of these blocks was imposed as the other was released confirmed that cells blocked by methylglyoxal bis(guanylhydrazone) are arrested at an earlier stage in G1 than cells blocked by calcium deprivation. PMID:6843551

  20. The Earlier the Better? Taking the AP® in 10th Grade. Research Report No. 2012-10

    Science.gov (United States)

    Rodriguez, Awilda; McKillip, Mary E. M.; Niu, Sunny X.

    2013-01-01

    In this report, the authors examine the impact of scoring a 1 or 2 on an AP® Exam in 10th grade on later AP Exam participation and performance. As access to AP courses increases within and across schools, a growing number of students are taking AP courses and exams in the earlier grades of high school. Using a matched sample of AP and no-AP…

  1. Earlier flowering did not alter pollen limitation in an early flowering shrub under short-term experimental warming

    OpenAIRE

    Pan, Cheng-Chen; Feng, Qi; Zhao, Ha-Lin; Liu, Lin-De; Li, Yu-Lin; Li, Yu-Qiang; Zhang, Tong-Hui; Yu, Xiao-Ya

    2017-01-01

    In animal pollinated plants, phenological shifts caused by climate change may have important ecological consequences. However, no empirical evidence exists at present on the consequences that flowering phenology shifts have on the strength of pollen limitation under experimental warming. Here, we investigated the effects of experimental warming on flowering phenology, flower density, reproductive success, and pollen limitation intensity in Caragana microphylla and evaluated whether earlier fl...

  2. A radioactive seed implant on a rabbit's liver following a voxel model representation for dosimetric proposals

    Energy Technology Data Exchange (ETDEWEB)

    Campos, Tarcisio P.R.; Andrade, Joao Paulo Lopes de; Costa, Igor Temponi; Teixeira, Cleuza H. [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Programa de Pos-graduacao em Ciencias e Tecnicas Nucleares]. E-mail: campos@nuclear.ufmg

    2005-07-01

    Animal models have been used in experimentation with ionizing radiation. The evaluation of the energy absorbed per unit tissue mass in vivo transported by nuclear particles is a task to be performed before experimentation. Stochastic or deterministic methodology can be applied, however the dosimetric protocols applied in radiotherapy center cannot be applied directly due to the inherent small geometry and chemical composition of the animal distinct from human. The present article addresses a method in development that will predict the dose distribution into the rabbit thorax based on the solution of the transport phenomena in a voxel model. The model will be applied to simulate a seed implant experiment on a rabbit. Herein, the construction of the three-dimensional voxel model anthropomorphic -anthropometrics to the rabbit is presented. The model is assembling from a set of computer tomography of the rabbit. The computational phantom of the thorax starts at the digitalisation of the CT images, tissue definition, and color image representation of each tissue and organ. The chemical composition and mass density of each tissue is evaluated as similar date presented by ICRU-44. To treat the images, a code namely SISCODES, developed in house, was used. The in vivo experiment that will be simulated is also described. That is a implant of five seeds of 1.6x2 mm performed in a rabbit's liver. The perspective of this work is the application of the model in dosimetric studies predicting the dose distribution around the seed's implanted in vivo experiments. (author)

  3. Proposed mechanistic description of dose-dependent BDE-47 urinary elimination in mice using a physiologically based pharmacokinetic model

    Energy Technology Data Exchange (ETDEWEB)

    Emond, Claude, E-mail: claude.emond@umontreal.ca [BioSimulation Consulting Inc., Newark, DE (United States); Departments of Environmental and Occupational Health, Medicine Faculty, University of Montreal, Montreal, Quebec (Canada); Sanders, J. Michael, E-mail: sander10@mail.nih.gov [National Cancer Institute, Research Triangle Park, NC (United States); Wikoff, Daniele, E-mail: dwikoff@toxstrategies.com [ToxStrategies, Austin, TX (United States); Birnbaum, Linda S., E-mail: birnbaumls@niehs.nih.gov [National Cancer Institute, Research Triangle Park, NC (United States)

    2013-12-01

    Polybrominated diphenyl ethers (PBDEs) have been used in a wide variety of consumer applications as additive flame retardants. In North America, scientists have noted continuing increases in the levels of PBDE congeners measured in human serum. Some recent studies have found that PBDEs are associated with adverse health effects in humans, in experimental animals, and wildlife. This laboratory previously demonstrated that urinary elimination of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) is saturable at high doses in mice; however, this dose-dependent urinary elimination has not been observed in adult rats or immature mice. Thus, the primary objective of this study was to examine the mechanism of urinary elimination of BDE-47 in adult mice using a physiologically based pharmacokinetic (PBPK) model. To support this objective, additional laboratory data were collected to evaluate the predictions of the PBPK model using novel information from adult multi-drug resistance 1a/b knockout mice. Using the PBPK model, the roles of mouse major urinary protein (a blood protein carrier) and P-glycoprotein (an apical membrane transporter in proximal tubule cells in the kidneys, brain, intestines, and liver) were investigated in BDE-47 elimination. The resulting model and new data supported the major role of m-MUP in excretion of BDE-47 in the urine of adult mice, and a lesser role of P-gp as a transporter of BDE-47 in mice. This work expands the knowledge of BDE-47 kinetics between species and provides information for determining the relevancy of these data for human risk assessment purposes. - Highlights: • We report the first study on PBPK model on flame retardant in mice for BDE-47. • We examine mechanism of urinary elimination of BDE-47 in mice using a PBPK model. • We investigated roles of m-MUP and P-gp as transporters in urinary elimination.

  4. Earlier BMI rebound and lower pre-rebound BMI as risk of obesity among Japanese preschool children.

    Science.gov (United States)

    Kato, N; Isojima, T; Yokoya, S; Tanaka, T; Ono, A; Yokomichi, H; Yamagata, Z; Tanaka, S; Matsubara, H; Ishikuro, M; Kikuya, M; Chida, S; Hosoya, M; Kuriyama, S; Kure, S

    2018-01-01

    Longitudinal growth data of children were analyzed to clarify the relationship between the timing of body mass index (BMI) rebound and obesity risk in later ages. Of 54 558 children born between April 2004 and March 2005 and longitudinally measured in April and October every year in the preschool period, 15 255 children were analyzed wherein no longitudinal measurement is missing after 1 year of age. BMI rebound age was determined as the age with smallest BMI value across longitudinal individual data after 1 year of age. Rebound age was compared between overweight and non-overweight groups. The subjects were divided into groups based on the timing of rebound. The sex- and age-adjusted mean of the BMI, height and weight s.d. scores for age group, along with 6 months weight and height gain, were compared among groups using analysis of covariance. Among those who were overweight at 66-71 months of age, BMI rebound age obtained at approximately 3 years of age was compared with the non-overweight group, whose BMI rebound age was utmost 66 months or later (PBMI age group showed that earlier BMI rebound results in larger BMI (PBMI rebound earlier than 30 months of age, low BMI was observed (PBMI rebound among groups with rebound age earlier than 60 months of age (PBMI rebound timing with pre-rebound low BMI leads to greater childhood obesity risk; hence, early detection and prevention is necessary for such cases.

  5. Study on the noncoincidence effect phenomenon using matrix isolated Raman spectra and the proposed structural organization model of acetone in condense phase

    Science.gov (United States)

    Xu, Wenwen; Wu, Fengqi; Zhao, Yanying; Zhou, Ran; Wang, Huigang; Zheng, Xuming; Ni, Bukuo

    2017-03-01

    The isotropic and anisotropic Raman spectra of acetone and deuterated acetone isolated in an argon matrix have been recorded for the understanding of noncoincidence effect (NCE) phenomenon. According to the matrix isolated Raman spectra and DFT calculations, we proposed aggregated model for the explanations of the acetone C=O vibration NCE phenomenon and its concentration effect. The experimental data were in consistence with the DFT calculations performed at the B3LYP-D3/6-311 G (d,p) levels based on the proposed model. The experimental identification of the monomer, dimer and trimer are reported here, and the dynamic of the transformation from monomer to aggregated structure can be easily controlled by tuning annealing temperature.

  6. From Personal Growth (1966) to Personal Growth and Social Agency (2016)--Proposing an Invigorated Model for the 21st Century

    Science.gov (United States)

    Goodwyn, Andrew

    2017-01-01

    The Personal Growth (PG) model, as outlined by John Dixon in 1967, is unquestionably still recognisable to English teachers, remaining aligned to their philosophy of teaching English. This article traces a key aspect of the history of Personal Growth and explores present continuities traceable to Dartmouth in 1966, in suggesting an invigorated…

  7. The Legacy of Rational Budgeting Models in Education and a Proposal for the Future. Project Report No. 83-A21.

    Science.gov (United States)

    Brackett, John; And Others

    This paper represents a backdrop from which to consider the development of a planning and budgeting model for local education agencies. The first part of the presentation describes the demands and external pressures that affect resource allocation decisions in school districts. The ability of local school officials to link the cost consequences…

  8. Higher dose rate Gamma Knife radiosurgery may provide earlier and longer-lasting pain relief for patients with trigeminal neuralgia.

    Science.gov (United States)

    Lee, John Y K; Sandhu, Sukhmeet; Miller, Denise; Solberg, Timothy; Dorsey, Jay F; Alonso-Basanta, Michelle

    2015-10-01

    Gamma Knife radiosurgery (GKRS) utilizes cobalt-60 as its radiation source, and thus dose rate varies as the fixed source decays over its half-life of approximately 5.26 years. This natural decay results in increasing treatment times when delivering the same cumulative dose. It is also possible, however, that the biological effective dose may change based on this dose rate even if the total dose is kept constant. Because patients are generally treated in a uniform manner, radiosurgery for trigeminal neuralgia (TN) represents a clinical model whereby biological efficacy can be tested. The authors hypothesized that higher dose rates would result in earlier and more complete pain relief but only if measured with a sensitive pain assessment tool. One hundred thirty-three patients were treated with the Gamma Knife Model 4C unit at a single center by a single neurosurgeon during a single cobalt life cycle from January 2006 to May 2012. All patients were treated with 80 Gy with a single 4-mm isocenter without blocking. Using an output factor of 0.87, dose rates ranged from 1.28 to 2.95 Gy/min. The Brief Pain Inventory (BPI)-Facial was administered before the procedure and at the first follow-up office visit 1 month from the procedure (mean 1.3 months). Phone calls were made to evaluate patients after their procedures as part of a retrospective study. Univariate and multivariate linear regression was performed on several independent variables, including sex, age in deciles, diagnosis, follow-up duration, prior surgery, and dose rate. In the short-term analysis (mean 1.3 months), patients' self-reported pain intensity at its worst was significantly correlated with dose rate on multivariate analysis (p = 0.028). Similarly, patients' self-reported interference with activities of daily living was closely correlated with dose rate on multivariate analysis (p = 0.067). A 1 Gy/min decrease in dose rate resulted in a 17% decrease in pain intensity at its worst and a 22% decrease

  9. Business process modeling applied to oil pipeline and terminal processes: a proposal for TRANSPETRO's oil pipelines and terminals in Rio de Janeiro and Minas Gerais

    Energy Technology Data Exchange (ETDEWEB)

    Santiago, Adilson da Silva [TRANSPETRO - PETROBRAS Transporte S.A., Rio de Janeiro, RJ (Brazil); Caulliraux, Heitor Mansur [Universidade Federal do Rio de Janeiro (COPPE/UFRJ/GPI), RJ (Brazil). Coordenacao de Pos-graduacao em Engenharia. Grupo de Producao Integrada; Almeida, Maria Fatima Ludovico de [Pontificia Universidade Catolica do Rio de Janeiro (PUC-Rio/ITUC), Rio de Janeiro, RJ (Brazil). Instituto Tecnologico; Felippe, Adriana Vieira de Oliveira [TRANSPETRO - PETROBRAS Transporte S.A., Rio de Janeiro, RJ (Brazil)

    2009-07-01

    Business process modeling (BPM) using event driven process chain diagrams (EPCs) to lay out business process work flows is now widely adopted around the world. The EPC method was developed within the framework of the ARIS Toolset developed by Prof. Wilhelm-August Scheer at the Institut fur Wirtschaftsinformatik at the Universitat des Saarlandes, in the early 1990s. It is used by many companies to model, analyze and redesign business processes. As such it forms the core technique for modeling in ARIS, which serves to link the different aspects of the so-called control view, which is discussed in the section on ARIS business process modeling. This paper describes a proposal made to TRANSPETRO's Oil Pipelines and Terminals Division in the states of Rio de Janeiro and Minas Gerais, which will be jointly developed by specialists and managers from TRANSPETRO and from COPPETEC, the collaborative research arm of Rio de Janeiro Federal University (UFRJ). The proposal is based on ARIS business process modeling and is presented here according to its seven phases, as follows: information survey and definition of the project structure; mapping and analysis of Campos Eliseos Terminal (TECAM) processes; validation of TECAM process maps; mapping and analysis of the remaining organizational units' processes; validation of the remaining organizational units' process maps; proposal of a business process model for all organizational units of TRANSPETRO's Oil Pipelines and Terminals Division in Rio de Janeiro and Minas Gerais; critical analysis of the process itself and the results and potential benefits of BPM. (author)

  10. A Proposal of B to B Collaboration Process Model based on a Concept of Service and its Application to Energy Saving Service Business

    Science.gov (United States)

    Zhang, Qi; Kosaka, Michitaka; Shirahada, Kunio; Yabutani, Takashi

    This paper proposes a new framework for B to B collaboration process based on a concept of service. Service value, which gives users satisfaction for provided services, depends on the situation, user characteristics, and user objectives in seeking the service. Vargo proposed Service Dominant Logic (SDL), which determines service value according to “value in use”. This concept illustrates the importance of the relationship between the service itself and its situation. This relationship is analogous to electro-magnetic field theory in physics. We developed the concept of service fields to create service value based on an analogy of the electro-magnetic field. By applying this concept to B to B collaboration, a model of service value co-creation in the collaboration can be formulated. Then, the collaboration can be described by 4 steps of KIKI model (Knowledge sharing related to service system, Identification of service field, Knowledge creation for new service idea, Implementation of service idea). As its application to B to B collaboration, the energy saving service business is reported to demonstrate the validity of the proposed collaboration model. This concept can be applied to make a collaboration process effective.

  11. First molecular modeling report on novel arylpyrimidine kynurenine monooxygenase inhibitors through multi-QSAR analysis against Huntington's disease: A proposal to chemists!

    Science.gov (United States)

    Amin, Sk Abdul; Adhikari, Nilanjan; Jha, Tarun; Gayen, Shovanlal

    2016-12-01

    Huntington's disease (HD) is caused by mutation of huntingtin protein (mHtt) leading to neuronal cell death. The mHtt induced toxicity can be rescued by inhibiting the kynurenine monooxygenase (KMO) enzyme. Therefore, KMO is a promising drug target to address the neurodegenerative disorders such as Huntington's diseases. Fiftysix arylpyrimidine KMO inhibitors are structurally explored through regression and classification based multi-QSAR modeling, pharmacophore mapping and molecular docking approaches. Moreover, ten new compounds are proposed and validated through the modeling that may be effective in accelerating Huntington's disease drug discovery efforts. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Proposal of a social alliance success model from a relationship marketing perspective: A meta-analytical study of the theoretical foundations

    Directory of Open Access Journals (Sweden)

    María Jesús Barroso-Méndez

    2015-07-01

    Full Text Available Partnerships between businesses and non-governmental organizations (NGOs have become widely adopted mechanisms for collaboration in addressing complex social issues, the aim being to take advantage of the two types of organizational rationale to generate mutual value. Many such alliances have proved to be unsuccessful, however. To assist managers improve the likelihood of success of their collaborative relationships, the authors propose a success model of business-NGO partnering processes based on Relationship Marketing Theory. They also analyse the theoretical bases of the model's hypotheses through a meta-analytical study of the existing literature.

  13. A sustainable business model for Open-Access journal publishing a proposed plan for High-Energy Physics

    CERN Document Server

    Vigen, Jens

    2007-01-01

    The High Energy Physics community over the last 15 years has achieved so-called full green Open Access through the wide dissemination of preprints via arXiv, a central subject repository managed by Cornell University. However, green Open Access does not alleviate the economic difficulties of libraries as they are still expected to offer access to versions of record of the peer-reviewed literature. For this reason the particle physics community is now addressing the issue of gold Open Access by converting a set of the existing core journals to Open Access. A Working Party has been established to bring together funding agencies, laboratories and libraries into a single consortium, called SCOAP3 (Sponsoring Consortium for Open Access Publishing in Particle Physics). This consortium will engage with publishers to build a sustainable model for Open Access publishing. In this model, subscription fees from multiple institutions are replaced by contracts with publishers of Open Access journals, where the SCOAP3 conso...

  14. A Proposed Model for Improving Performance and Reducing Costs of IT Through Cloud Computing of Egyptian Business Enterprises

    OpenAIRE

    Mohamed M.El Hadi; Azza Monir Ismail

    2016-01-01

    Information technologies are affecting the big business enterprises of todays from data processing and transactions to achieve the goals efficiently and effectively, affecting creates new business opportunities and towards new competitive advantage, service must be enough to match the recent trends of IT such as cloud computing. Cloud computing technology has provided all IT services. Therefore, cloud computing offers an alternative to adaptable with technology model current , creating reduci...

  15. Propose a Model for Customer Purchase Decision in B2C Websites Using Adaptive Neuro-Fuzzy Inference System

    OpenAIRE

    Mehrbakhsh Nilashi, Mohammad Fathian, Mohammad Reza Gholamian, Othman bin Ibrahim

    2011-01-01

    If companies are to enjoy long-term success in the Internet marketplace, they must effectivelymanage the complex, multidimensional process of building online consumer trust. The onlineenvironment and the quality and usability of websites help the browser and consumer to beattracted and accessible to the information and the product and services available online. In thisPaper a new model would be suggested based on neuro-fuzzy System which depicts some of thehidden relationships between the cri...

  16. Proposing a model for safety risk assessment in the construction industry using gray multi-criterion decision-making

    Directory of Open Access Journals (Sweden)

    S. M. Abootorabi

    2014-09-01

    Full Text Available Introduction: Statistical Report of the Social Security Organization indicate that among the various industries, the construction industry has the highest number of work-related accidents so that in addition to frequency, it has high intensity, as well. On the other hand, a large number of human resources are working in this whish shows they necessity for paying special attention to these workers. Therefore, risk assessment of the safety in the construction industry is an effective step in this regard. In this study, a method for ranking safety risks in conditions of low number of samples and uncertainty is presented, using gray multi-criterion decision-making. .Material and Method: In this study, we first identified the factors affecting the occurrence of hazards in the construction industry. Then, appropriate for ranking the risks were determined and the problem was defined as a multi-criterion decision-making. In order to weight the criteria and to evaluate alternatives based on each criterion, gray numbers were used. In the last stage, the problem was solved using the gray possibility degree. .Results: The results show that the method of gray multi-criterion decision-making is an effective method for ranking risks in situations of low samples compared with other methods of MCDM. .Conclusion: The proposed method is preferred to fuzzy methods and statistics in uncertain and low sample size, due to simple calculations and no need to define the membership function.

  17. Proposal of thinking process model based on putting a question to oneself for problem solving by skilled engineers

    International Nuclear Information System (INIS)

    Fukumoto, Toshihiko; Kishi, Yoshiki

    2007-01-01

    The retirement of the skilled engineers and researchers, who have been working in the field of water chemistry of BWRs since the establishment of Japanese BWRs, has been accelerating so that it is necessary to preserve and share the knowledge and know-how of these skilled engineers and to effectively and securely inherit them to the following generations. Moreover, in order for other engineers to share knowledge, including the tacit knowledge of a skilled engineer, it is necessary not only to understand the knowledge obtained as the results of the thinking of the skilled engineers but also to externalize and experience their thinking processes as the processes of problem solving that produced the results. The target of this research is to build a new thinking process model that can externalize thinking processes effectively by analyzing the knowledge and thinking contents of the skilled engineers for investigating causes of changes in the quality of reactor water in boiling water reactor type power plants. As part of this research, we found out a new metacognitive activity, Putting a Question to Oneself, which plays a large role in the thinking process structure. In addition, we developed a new fundamental thinking process model, which can externalize thinking processes effectively by integrating the concept of Putting a Question to Oneself into the thinking process model. (author)

  18. Optimising the introduction of multiple childhood vaccines in Japan: A model proposing the introduction sequence achieving the highest health gains.

    Science.gov (United States)

    Standaert, Baudouin; Schecroun, Nadia; Ethgen, Olivier; Topachevskyi, Oleksandr; Morioka, Yoriko; Van Vlaenderen, Ilse

    2017-12-01

    Many countries struggle with the prioritisation of introducing new vaccines because of budget limitations and lack of focus on public health goals. A model has been developed that defines how specific health goals can be optimised through immunisation within vaccination budget constraints. Japan, as a country example, could introduce 4 new pediatric vaccines targeting influenza, rotavirus, pneumococcal disease and mumps with known burden of disease, vaccine efficacies and maximum achievable coverages. Operating under budget constraints, the Portfolio-model for the Management of Vaccines (PMV) identifies the optimal vaccine ranking and combination for achieving the maximum QALY gain over a period of 10 calendar years in children optimal sequence of vaccine introduction (mumps [1st], followed by influenza [2nd], rotavirus [3rd], and pneumococcal [4th]). With exactly the same budget but without vaccine ranking, the total QALY gain can be 20% lower. The PMV model could be a helpful tool for decision makers in those environments with limited budget where vaccines have to be selected for trying to optimise specific health goals. Copyright © 2017 GlaxoSmithKline Biologicals SA. Published by Elsevier B.V. All rights reserved.

  19. Collaborative Proposal: Improving Decadal Prediction of Arctic Climate Variability and Change Using a Regional Arctic System Model (RASM)

    Energy Technology Data Exchange (ETDEWEB)

    Robertson, William [Univ. of Texas, El Paso, TX (United States)

    2016-11-18

    RASM is a multi-disciplinary project, which brings together researchers from six state universities, one military postgraduate school, and one DoE laboratory to address the core modeling objectives of the arctic research community articulated in the Arctic System Modeling report by Roberts et al. (2010b). This report advocates the construction of a regional downscaling tool to generate probabilistic decadal projections of Greenland ice sheet retreat, evolution of arctic sea ice cover, changes in land surface vegetation, and regional processes leading to arctic amplification. Unified coupled models such as RASM are ideal for this purpose because they simulate fine-scale physics, essential for the realistic representation of intra-annual variability, in addition to processes fundamental to long term climatic shifts (Hurrell et al. 2009). By using RASM with boundary conditions from a global model, we can generate many-member ensembles essential for understanding uncertainty in regional climate projections (Hawkins and Sutton 2009). This probabilistic approach is computationally prohibitive for high-resolution global models in the foreseeable future, and also for regional models interactively nested within global simulations. Yet it is fundamental for quantifying uncertainty in decadal forecasts to make them useful for decision makers (Doherty et al. 2009). For this reason, we have targeted development of ensemble generation techniques as a core project task (Task 4.5). Environmental impact assessment specialists need high-fidelity regional ensemble projections to improve the accuracy of their work (Challinor et al. 2009; Moss et al. 2010). This is especially true of the Arctic, where economic, social and national interests are rapidly reshaping the high north in step with regional climate change. During the next decade, considerable oil and gas discoveries are expected across many parts of the marine and terrestrial Arctic (Gautier et al. 2009), the economics of the

  20. Suicide detection in Chile: proposing a predictive model for suicide risk in a clinical sample of patients with mood disorders

    Directory of Open Access Journals (Sweden)

    Jorge Barros

    Full Text Available Objective: To analyze suicidal behavior and build a predictive model for suicide risk using data mining (DM analysis. Methods: A study of 707 Chilean mental health patients (with and without suicide risk was carried out across three healthcare centers in the Metropolitan Region of Santiago, Chile. Three hundred forty-three variables were studied using five questionnaires. DM and machine-learning tools were used via the support vector machine technique. Results: The model selected 22 variables that, depending on the circumstances in which they all occur, define whether a person belongs in a suicide risk zone (accuracy = 0.78, sensitivity = 0.77, and specificity = 0.79. Being in a suicide risk zone means patients are more vulnerable to suicide attempts or are thinking about suicide. The interrelationship between these variables is highly nonlinear, and it is interesting to note the particular ways in which they are configured for each case. The model shows that the variables of a suicide risk zone are related to individual unrest, personal satisfaction, and reasons for living, particularly those related to beliefs in one’s own capacities and coping abilities. Conclusion: These variables can be used to create an assessment tool and enables us to identify individual risk and protective factors. This may also contribute to therapeutic intervention by strengthening feelings of personal well-being and reasons for staying alive. Our results prompted the design of a new clinical tool, which is fast and easy to use and aids in evaluating the trajectory of suicide risk at a given moment.

  1. A fast and robust kinematic model for a 12 DoF hyper-redundant robot positioning: An optimization proposal

    Science.gov (United States)

    Lima, José; Pereira, Ana I.; Costa, Paulo; Pinto, Andry; Costa, Pedro

    2017-07-01

    This paper describes an optimization procedure for a robot with 12 degrees of freedom avoiding the inverse kinematics problem, which is a hard task for this type of robot manipulator. This robot can be used to pick and place tasks in complex designs. Combining an accurate and fast direct kinematics model with optimization strategies, it is possible to achieve the joints angles for a desired end-effector position and orientation. The optimization methods stretched simulated annealing algorithm and genetic algorithm were used. The solutions found were validated using data originated by a real and by a simulated robot formed by 12 servomotors with a gripper.

  2. A GIS-Based Proposal for Modeling the “Lenteja” Zone of the CIEMAT Head Courted (Madrid)

    International Nuclear Information System (INIS)

    Marina, J; Andrés, N de; Carroza, J.A; Quiñones, J.

    2015-01-01

    CIEMAT is devoted to different activities relate to Decommissioning and Dismantling of all Radioactive irradiation facilities. Focusing on that this paper has the main objective of: to design a methodology for evaluating the geological structure of the site. This methodology allows description, modelling of the radionuclide migration in the soil. Although the idea is following the same methodology input the rest of the CIEMAT head courter site. In this paper is written a detailed description of the block diagram and geological profiles obtained, in which the sedimentary architecture of the subsoil of the study area and the location and volume of confined aquifers present in ''lenteja'' are localised.

  3. Biogeochemical fingerprints of life: earlier analogies with polar ecosystems suggest feasible instrumentation for probing the Galilean moons

    Science.gov (United States)

    Chela-Flores, J.; Cicuttin, A.; Crespo, M. L.; Tuniz, C.

    2015-07-01

    We base our search for the right instrumentation for detecting biosignatures on Europa on the analogy suggested by the recent work on polar ecosystems in the Canadian Arctic at Ellesmere Island. In that location sulphur patches (analogous to the Europan patches) are accumulating on glacial ice lying over saline springs rich in sulphate and sulphide. Their work reinforces earlier analogies in Antarctic ecosystems that are appropriate models for possible habitats that will be explored by the European Space Agency JUpiter ICy Moons Explorer (JUICE) mission to the Jovian System. Its Jupiter Ganymede Orbiter (JGO) will include orbits around Europa and Ganymede. The Galileo orbital mission discovered surficial patches of non-ice elements on Europa that were widespread and, in some cases possibly endogenous. This suggests the possibility that the observed chemical elements in the exoatmosphere may be from the subsurface ocean. Spatial resolution calculations of Cassidy and co-workers are available, suggesting that the atmospheric S content can be mapped by a neutral mass spectrometer, now included among the selected JUICE instruments. In some cases, large S-fractionations are due to microbial reduction and disproportionation (although sometimes providing a test for ecosystem fingerprints, even though with Sim - Bosak - Ono we maintain that microbial sulphate reduction large sulphur isotope fractionation does not require disproportionation. We address the question of the possible role of oxygen in the Europan ocean. Instrument issues are discussed for measuring stable S-isotope fractionations up to the known limits in natural populations of δ34 ~ -70‰. We state the hypothesis of a Europa anaerobic oceanic population of sulphate reducers and disproportionators that would have the effect of fractionating the sulphate that reaches the low-albedo surficial regions. This hypothesis is compatible with the time-honoured expectation of Kaplan and co-workers (going back to the

  4. Life Cycle Assessment Modelling of Greenhouse Gas Emissions from Existing and Proposed Municipal Solid Waste Management System of Lahore, Pakistan

    Directory of Open Access Journals (Sweden)

    Adila Batool Syeda

    2017-12-01

    Full Text Available Open Dumping of indiscriminate municipal solid waste (MSW remarkably contributes to global warming (GW. Life Cycle Assessment modelling may be a useful tool for assessing the best waste management option regarding GW potential. The current study evaluates the contribution of an existing MSW management (MSWM system to greenhouse gases in Gulberg Town, Lahore, Pakistan. This research also presents a comparison of scenarios with different waste management options. Life Cycle Assessment methodology has been used to conduct the study. EASETECH has been used for modelling. The short-term scenarios (STSs have been developed to promote the thinking of integration of treatment technologies in the current waste management system within a few months. The results show that the major contribution to the total emissions comes from the anaerobic digestion of organic material from open waste dumps. Currently, recycling is the best treatment option for reducing the CO2-eq values in the study area. It was clarified that recycling is the best option for reducing the CO2-eq values, whereas biogasification comes in second in terms of savings and reduction. The integration of recycling and biogasification techniques would be a good solution.

  5. A sustainable business model for Open-Access journal publishing: a proposed plan for High-Energy Physics

    Directory of Open Access Journals (Sweden)

    Jens Vigen

    2008-01-01

    Full Text Available The High Energy Physics community over the last 15 years has achieved so-called full green Open Access through the wide dissemination of preprints via arXiv, a central subject repository managed by Cornell University. However, green Open Access does not alleviate the economic difficulties of libraries as they are still expected to offer access to versions of record of the peer-reviewed literature. For this reason the particle physics community is now addressing the issue of gold Open Access by converting a set of the existing core journals to Open Access. A Working Party has been established to bring together funding agencies, laboratories and libraries into a single consortium, called SCOAP3 (Sponsoring Consortium for Open Access Publishing in Particle Physics. This consortium will engage with publishers to build a sustainable model for Open Access publishing. In this model, subscription fees from multiple institutions are replaced by contracts with publishers of Open Access journals, where the SCOAP3 consortium is a single financial partner.

  6. The “unknown” Greek Paleoenvironment: Curriculum Proposals through an Infusion Model for Elementary School, Using Ammonite Fossils

    Directory of Open Access Journals (Sweden)

    Stiliani FRAGOULI

    2017-06-01

    Full Text Available In this study we introduce an infusion model to “inject” ammonites and ammonite fossils in current subjects of Greek primary curriculum. Paleontology and mainly fossils attract more and more elementary students and teachers, yet in Greece this trend is solely about dinosaurs, despite the fact that the most common Greek fossils are not dinosaurs, but ammonites. Ammonites can be found in large population and diversity inside Greek rocks, as these rocks were part of Tethys΄ seafloor at their geological time. Apart from the informal sources of education, these science topics are excluded from elementary national curriculum, and leave the regional paleoenvironment and geological history practically “unknown” to students. Data collected through a pre-test study, in 558 students of 4th, 5th, and 6th grade confirmed the above belief. A post-test at the original sample, using an open ended questionnaire and students’ drawings, evaluated positively the infusion teaching model, whose core were the ammonite fossils.

  7. Numerical modeling of gas migration at a proposed repository for low and intermediate level nuclear wastes at Oberbauenstock, Switzerland

    International Nuclear Information System (INIS)

    Pruess, K.

    1990-03-01

    Hydrologic impacts of corrosive gas release from a hypothetical L/ILW nuclear waste repository at Oberbauenstock are explored by means of numerical simulation. A schematic two dimensional vertical section through the mountain is modeled with the simulator TOUGH, which describes two-phase flow of water and gas in porous and fractured media. Two reference cases are considered which represent the formations as a porous and as a fractured-porous (dual permeability) medium, respectively. Both cases predict similar and rather modest pressure increases, from ambient 10 bars to near 25 bars at the repository level. These results are to be considered preliminary because important parameters affecting two-phase flow, such as relative permeabilities of a fractured medium, are not well known at present. 24 refs., 15 figs., 5 tabs

  8. Life cycle inventory modelling of land use induced by crop consumption - Part 1: Conceptual analysis and methodological proposal

    DEFF Research Database (Denmark)

    Kløverpris, Jesper; Wenzel, Henrik; Nielsen, Per H.

    2008-01-01

    Background, Aims and Scope. The actual land use consequences of crop consumption are not very well reflected in existing life cycle inventories. The state of the art is that such inventories typically include data from crop production in the country in which the crop is produced, and consequently...... to reflect long-term changes, and possibly establishment of a link between crop demand and technological development. Through this approach, life cycle inventories for crops reflecting the actual land use consequences of consumption can be established.Recommendations and Perspectives. Further work (based...... use consequences of crop consumption.Results. Based on the current market trend for crops and an analysis of basic mechanisms in crop production, concepts for modelling how crop consumption affects the global agricultural area and the intensity of crop production are suggested. It is demonstrated how...

  9. The proposal for the development of a nonformal education activities model for teachers in foundations for disadvantaged children

    Directory of Open Access Journals (Sweden)

    Jinanarong Siriporn

    2016-01-01

    Full Text Available The dramatic increase in the numbers of disadvantaged children (or under privileged children in the past few years has become a considerable concern for Thailand. Educators are worried about the quality of these children’s education. The demand for quality educators has increased for these children. This paper describes a newly developed model for teacher’s education. It targets the teachers who teach disadvantaged children in the foundations. The objective of the research step is to expose the children to aesthetic experience by using experiential learning and brain based learning. The target group is pre-school children who are under the care of foundations in Bangkok metropolitan areas.

  10. Proposing a Holistic Model for Formulating the Security Requirements of e-learning based on Stakeholders’ Point of Veiw

    Directory of Open Access Journals (Sweden)

    Abouzar Arabsorkhi Mishabi

    2016-03-01

    Full Text Available Development of e-learning applications and services in the context of information and communication networks –beside qualitative and quantitative improvement in the scope and range of services they provide – has increased veriety of threats which are emerged from these networks and telecommunications infrastructure. This kind of issue have mad the effective and accurate analysing of security issues nessesary to managers and decision makers. Accordingly, in this study, using findings of other studies in the field of e-learning security, using methasyntesis, attempted to define a holistic model for classification and organization of security requirements. A structure that defines the origin of security requirements of e-learning and rolplays as a reference for formulating security requirements for this area.

  11. Algorithms to analyze the quality test parameter values of seafood in the proposed ontology based seafood quality analyzer and miner (ONTO SQAM model

    Directory of Open Access Journals (Sweden)

    Vinu Sherimon

    2017-07-01

    Full Text Available Ensuring the quality of food, particularly seafood has increasingly become an important issue nowadays. Quality Management Systems empower any organization to identify, measure, control and improve the quality of the products manufactured that will eventually lead to improved business performance. With the advent of new technologies, now intelligent systems are being developed. To ensure the quality of seafood, an ontology based seafood quality analyzer and miner (ONTO SQAM model is proposed. The knowledge is represented using ontology. The domain concepts are defined using ontology. This paper presents the initial part of the proposed model – the analysis of quality test parameter values. Two algorithms are proposed to do the analysis – Comparison Algorithm and Data Store Updater algorithm. The algorithms ensure that the values of various quality tests are in the acceptable range. The real data sets taken from different seafood companies in Kerala, India, and validated by the Marine Product Export Development Authority of India (MPEDA are used for the experiments. The performance of the algorithms is evaluated using standard performance metrics such as precision, recall, and accuracy. The results obtained show that all the three measures achieved good results.

  12. Hereditary gynaecologic cancers in Nepal: a proposed model of care to serve high risk populations in developing countries.

    Science.gov (United States)

    Pokharel, Hanoon P; Hacker, Neville F; Andrews, Lesley

    2017-01-01

    Endometrial, ovarian and breast cancers are paradigms for global health disparity. Women living in the developing world continue to present in later stages of disease and have fewer options for treatment than those in developed countries. Risk reducing surgery is of proven benefit for women at high risk of gynaecological cancer. There is no specific model for identification and management of such women in the developing world. We have integrated data from our published audit of a major gynaecological oncology centre at Royal Hospital for Women in Australia, with data from our survey and a focus group discussion of Nepalese gynaecological health care professionals regarding genetic testing, and findings from the literature. These data have been used to identify current barriers to multidisciplinary gynaecological oncology care in developing nations, and to develop a model to integrate hereditary cancer services into cancer care in Nepal, as a paradigm for other developing nations. The ability to identify women with hereditary gynaecological cancer in developing nations is influenced by their late presentation (if active management is declined or not appropriate), limited access to specialised services and cultural and financial barriers. In order to include genetic assessment in multidisciplinary gynaecological cancer care, education needs to be provided to all levels of health care providers to enable reporting of family history, and appropriate ordering of investigations. Training of genetic counsellors is needed to assist in the interpretation of results and extending care to unaffected at-risk relatives. Novel approaches will be required to overcome geographic and financial barriers, including mainstreaming of genetic testing, telephone counselling, use of mouth swabs and utilisation of international laboratories. Women in Nepal have yet to receive benefits from the advances in early cancer diagnosis and management. There is a potential of extending the benefits

  13. A proposal of conceptual model for Pertuso Spring discharge evaluation in the Upper Valley of Aniene River

    Directory of Open Access Journals (Sweden)

    Giuseppe Sappa

    2016-10-01

    Full Text Available The Upper Aniene River basin is part of a large karst aquifer, which interacts with the river, and represents the most important water resource in the southeast part of Latium Region, Central Italy, used for drinking, agriculture and hydroelectric supplies. This work provides hydrogeochemical data and their interpretations for 1 spring and 2 cross section of Aniene River, monitored from July 2014 to December 2015, in the Upper Valley of Aniene River, to identify flow paths and hydrogeochemical processes governing groundwater-surface water interactions in this region. These activities deal with the Environmental Monitoring Plan made for the catchment work project of the Pertuso Spring, in the Upper Valley of Aniene River, which is going to be exploited to supply an important drinking water network in the South part of Rome district. Discharge measurements and hydrogeochemical data were analyzed to develop a conceptual model of aquifer-river interaction, with the aim of achieving proper management and protection of this important hydrogeological system. All groundwater samples are characterized as Ca-HCO3 type. Geochemical modeling and saturation index computation of the water samples show that groundwater and surface water chemistry in the study area was evolved through the interaction with carbonate minerals. All groundwater samples were undersaturated with respect to calcite and dolomite, however some of the Aniene River samples were saturated with respect to dolomite. The analysis of Mg2+/Ca2+ ratios indicates that the dissolution of carbonate minerals is important for groundwater and surface water chemistry, depending on the hydrological processes, which control the groundwater residence time and chemical equilibria in the aquifer.

  14. Restructuring proposed for Mexico's Pemex

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    Mexican President Carlos Salinas de Gortari soon will send a legislative proposal to Congress that splits state owned Petroleos Mexicanos into four subsidiaries. This paper reports that Pemex functions will be divided into Pemex Exploration ampersand Production, Pemex Refining, Pemex Gas ampersand Basic Petrochemicals, and Pemex Secondary Chemicals. An earlier report the the company would be split into seven units. Each of the four new operating companies will be an independent business unit with a separate board of directors and its own staff and support functions

  15. Proposed improvements to a model for characterizing the electrical and thermal energy performance of stirling engine micro-cogeneration devices based upon experimental observations

    Energy Technology Data Exchange (ETDEWEB)

    Lombardi, K. [CanmetENERGY, 1 Haanel Drive, Ottawa, Ont. (Canada); Ugursal, V.I. [Dalhousie University, Halifax, NS (Canada); Beausoleil-Morrison, I. [Carleton University, 1125 Colonel By Drive, Ottawa, Ont. (Canada)

    2010-10-15

    Stirling engines (SE) are a market-ready technology suitable for residential cogeneration of heat and electricity to alleviate the increasing demand on central power grids. Advantages of this external combustion engine include high cogeneration efficiency, fuel flexibility, low noise and vibration, and low emissions. To explore and assess the feasibility of using SE based cogeneration systems in the residential sector, there is a need for an accurate and practical simulation model that can be used to conduct sensitivity and what-if analyses. A simulation model for SE based residential scale micro-cogeneration systems was recently developed; however the model is impractical due to its functional form and data requirements. Furthermore, the available experimental data lack adequate diversity to assess the model's suitability. In this paper, first the existing model is briefly presented, followed by a review of the design and implementation of a series of experiments conducted to study the performance and behaviour of the SE system and to develop extensive, and hitherto unavailable, operational data. The empirical observations are contrasted with the functional form of the existing simulation model, and improvements to the structure of the model are proposed based upon these observations. (author)

  16. Model-based development and testing of advertising messages: A comparative study of two campaign proposals based on the MECCAS model and a conventional approach

    DEFF Research Database (Denmark)

    Bech-Larsen, Tino

    2001-01-01

    Traditionally, the development of advertising messages has been based on "creative independence", sometimes catalysed by inductively generated empirical data. Due to the recent intensified focus on advertising effectiveness, this state of affairs is beginning to change. The purpose of the study....... The comparison involved the efficiency of the managerial communication taking place in the message development process as well as target group communication effects. The managerial communication was studied by interviews with the involved advertising agency (Midtmarketing, Ikast, Denmark) and client staff...... described in this article is to compare the development and effects of two campaign proposals, with the sommon aim of increasing the consumption of apples among young Danes (18 to 35 years of age). One of the proposals is the result of an inductive-creative process, while the other is base on the MECCAS...

  17. A proposed conceptual model of green practices impacting on the tourism business and their performances – A case of Phu Quoc island Vietnam

    Directory of Open Access Journals (Sweden)

    Vu Minh Hieu

    2017-06-01

    Full Text Available The purpose of this article is to propose a conceptual green practices model in the tourism industry of Phu Quoc island (destination in Vietnam. The model is developed with purpose of providing direction for researchers to empirically examine relationships among demographic variables, innovation characteristics, performance expectancy, social influence, facilitating conditions and effort expectancy, funding availability and environment and business performances. This study uses the secondary research data which is collected from different sources as books, journals, research papers and other online and print media (publications on the subject. The main method used in this study is the content review and analysis. The author suggests that an empirical study should be done to confirm if relationships of variables exit or need to be changed to adapt with the currents of the destination to increase business performance. This model is expected to contribute to the theory of tourism and to apply to Phu Quoc island.

  18. Digital curation: a proposal of a semi-automatic digital object selection-based model for digital curation in Big Data environments

    Directory of Open Access Journals (Sweden)

    Moisés Lima Dutra

    2016-08-01

    Full Text Available Introduction: This work presents a new approach for Digital Curations from a Big Data perspective. Objective: The objective is to propose techniques to digital curations for selecting and evaluating digital objects that take into account volume, velocity, variety, reality, and the value of the data collected from multiple knowledge domains. Methodology: This is an exploratory research of applied nature, which addresses the research problem in a qualitative way. Heuristics allow this semi-automatic process to be done either by human curators or by software agents. Results: As a result, it was proposed a model for searching, processing, evaluating and selecting digital objects to be processed by digital curations. Conclusions: It is possible to use Big Data environments as a source of information resources for Digital Curation; besides, Big Data techniques and tools can support the search and selection process of information resources by Digital Curations.

  19. Put a tiger in your tank: the polyclad flatworm Maritigrella crozieri as a proposed model for evo-devo.

    Science.gov (United States)

    Lapraz, François; Rawlinson, Kate A; Girstmair, Johannes; Tomiczek, Bartłomiej; Berger, Jürgen; Jékely, Gáspár; Telford, Maximilian J; Egger, Bernhard

    2013-10-09

    Polyclad flatworms are an early branching clade within the rhabditophoran Platyhelminthes. They provide an interesting system with which to explore the evolution of development within Platyhelminthes and amongst Spiralia (Lophotrochozoa). Unlike most other flatworms, polyclads undergo spiral cleavage (similar to that seen in some other spiralian taxa), they are the only free-living flatworms where development via a larval stage occurs, and they are the only flatworms in which embryos can be reared outside of their protective egg case, enabling embryonic manipulations. Past work has focused on comparing early cleavage patterns and larval anatomy between polyclads and other spiralians. We have selected Maritigrella crozieri, the tiger flatworm, as a suitable polyclad species for developmental studies, because it is abundant and large in size compared to other species. These characteristics have facilitated the generation of a transcriptome from embryonic and larval material and are enabling us to develop methods for gene expression analysis and immunofluorescence techniques. Here we give an overview of M. crozieri and its development, we highlight the advantages and current limitations of this animal as a potential evo-devo model and discuss current lines of research.

  20. Model-Scale Aerodynamic Performance Testing of Proposed Modifications to the NASA Langley Low Speed Aeroacoustic Wind Tunnel

    Science.gov (United States)

    Booth, Earl R., Jr.; Coston, Calvin W., Jr.

    2005-01-01

    Tests were performed on a 1/20th-scale model of the Low Speed Aeroacoustic Wind Tunnel to determine the performance effects of insertion of acoustic baffles in the tunnel inlet, replacement of the existing collector with a new collector design in the open jet test section, and addition of flow splitters to the acoustic baffle section downstream of the test section. As expected, the inlet baffles caused a reduction in facility performance. About half of the performance loss was recovered by addition the flow splitters to the downstream baffles. All collectors tested reduced facility performance. However, test chamber recirculation flow was reduced by the new collector designs and shielding of some of the microphones was reduced owing to the smaller size of the new collector. Overall performance loss in the facility is expected to be a 5 percent top flow speed reduction, but the facility will meet OSHA limits for external noise levels and recirculation in the test section will be reduced.

  1. Analysis of effectiveness of three forest interventionist techniques and proposal of a new and integrated model of forest restoration.

    Science.gov (United States)

    Castelli, Karen Regina; Barreto, Mariana Gregorio; Francesconi, Wendy; Dalla Valle, Leandro; Mondelli, Giulliana; Abilio, Fernanda Maria; da Silva, Alexandre Marco

    2015-01-01

    We assessed the efficacy of three different forest intervention techniques, in terms of phytosociological and edaphic responses, that were implemented in 2007. In a farm where trees are planted and managed for cellulose production as well as set aside for environmental conservation, four stands were analysed: three of them were considered degraded and were managed using different intervention techniques (transposition, perch, and abandonment), and a fourth stand comprising pristine vegetation was considered a control (reference). Floristic and phytosociology data were collected in three 10 × 10 m plots established in each stand. Also, a total of 48 soil samples were collected to analyse physical and chemical attributes of the topsoil for the different stands. In terms of biodiversity, all the treatments showed significantly lower values when compared to the reference area. However, the soils in all the treatment and reference stands are similar in terms of physical and chemical attributes. Taking into account the specificities of each restoration technique, we verified that the integrated use of a set of management practices, constituted by the (1) abandonment of the area and (2) following a selective killing of the eucalyptus, is the most suitable and promising model to provide fast and effective restoration in terms of environmental indicators.

  2. Proposal for a Conceptual Model for Evaluating Lean Product Development Performance: A Study of LPD Enablers in Manufacturing Companies

    Science.gov (United States)

    Osezua Aikhuele, Daniel; Mohd Turan, Faiz

    2016-02-01

    The instability in today's market and the emerging demands for mass customized products by customers, are driving companies to seek for cost effective and time efficient improvements in their production system and this have led to real pressure for the adaptation of new developmental architecture and operational parameters to remain competitive in the market. Among such developmental architecture adopted, is the integration of lean thinking in the product development process. However, due to lack of clear understanding of the lean performance and its measurements, many companies are unable to implement and fully integrate the lean principle into their product development process and without a proper performance measurement, the performance level of the organizational value stream will be unknown and the specific area of improvement as it relates to the LPD program cannot be tracked. Hence, it will result in poor decision making in the LPD implementation. This paper therefore seeks to present a conceptual model for evaluation of LPD performances by identifying and analysing the core existing LPD enabler (Chief Engineer, Cross-functional teams, Set-based engineering, Poka-yoke (mistakeproofing), Knowledge-based environment, Value-focused planning and development, Top management support, Technology, Supplier integration, Workforce commitment and Continuous improvement culture) for assessing the LPD performance.

  3. A clustering model proposal for activity optimization vs. image quality. Application in HMPAO-99mTc brain SPECT

    International Nuclear Information System (INIS)

    Perez, M.; Diaz, O.; Estevez, E.; Roque, R.; Hernandez, C.

    2008-01-01

    A method based on clustering analysis and image quality discriminant functions is tested over HMPAO- 99m Tc -SPECT images to optimize image quality vs. administered activity to patient. Signal-to-Noise ratios and Signal-to-Background ratios in each transaxial slice were measured over the images and used as image quality objective indexes. They were employed to develop image quality classification using a model of three clusters (k-mean Cluster Technique). The mathematical classification was compared with the subjective image quality evaluation, following expert observer criterion. Linear image quality discrimination was developed using the results of the cluster classification and taking as independent variables: the characteristics of the patients (sex, age and weight) and the radiopharmaceutical (labelling yield and administered activity). The dependent variables in the discriminant functions were the cluster centroids. The objective of this procedure was assigning a statistical weight to each image quality determinant variable for the optimization purpose. The method was applied in 30 brain SPECT images, acquired under different activities (400 MBq, 600 MBq, 800 MBq and 1000 MBq as reference), with a Sopha gamma camera, mean-resolution - general purpose - parallel-hole collimator, acquisition matrix 128 x 128 pixels and reconstruction following Filter - Back - Projection Algorithm. We looked for the minimum activity that guaranty most of the cases classified into the cluster with the best image quality (optimization criterion). The value of 800 MBq was the optimum obtained after application of the above methodology for the technology used. The labelling yield and the weight of the patients were the main parameters which determined image quality in clusters, as well as the processing digital filter used. The reduction in the effective dose, as a consequence of this procedure implementation, was also analysed. (author)

  4. Earlier (late Pliocene) first appearance of the Caribbean reef-building coral Acropora palmata: Stratigraphic and evolutionary implications

    Science.gov (United States)

    McNeill, Donald F.; Budd, Ann F.; Borne, Pamela F.

    1997-10-01

    An integrated stratigraphic study of reefal deposits on the Caribbean side of the Isthmus of Panama (Limon, Costa Rica) has discovered a significantly earlier first appearance of the major reef-building coral Acropora palmata. A. palmata is here reported from the early late Pliocene, constrained in age to within the Gauss chron (ca. 3.6 2.6 Ma). This coral was previously thought to have originated in the earliest Pleistocene and has subsequently been used as a Quaternary marker throughout the Caribbean and the Bahamas. An earlier appearance in the southern Caribbean implies a diachronous first appearance datum relative to the northern Caribbean. This older age also places A. palmata well within the transition phase of a Pliocene (4 1 Ma) faunal turnover that was marked by widespread extinction and origination of Caribbean coral species. An early late Pliocene origination is coincident with formation of the Isthmus, climate reorganization, and frequent sea-level changes associated with onset of Northern Hemisphere glaciations. The rapid growth and accumulation rates that characterize A. palmata may therefore be adaptive to these fluctuating environmental conditions, enabling its success during the subsequent Pleistocene glacial cycles.

  5. Proposal of a model for evaluation of research and development projects in a public scientific and technological institution: a survey in CNEN

    International Nuclear Information System (INIS)

    Silva, Eduardo de Assumpcao

    2017-01-01

    Science and technology are directly related to the development of a country. The research and development projects in CNEN are financed by the direct resources of the budget of the Union and of the Development Agencies such as FINEP and CNPq. In general, project managers believe they can succeed when they complete a project on schedule, budget, and anticipated requirements, which is commonly known as a 'triple constraint' or 'iron triangle'. However, in the review of the literature, other criteria for evaluating success in projects, such as the benefits generated by society, the development of the team's capabilities, future opportunities, new technologies, among others, were verified. In this way, in order to assist the manager in the evaluation of this type of project, the present research carried out a review in the literature aiming to find concepts about success in projects and their evaluation criteria, proposed a model based on the theoretical reference and Importance and use of these criteria with the CNEN specialists, who work directly in the R and D projects of a public ICT in the nuclear area. The results showed that the criteria proposed in the model have a high degree of importance and show a decrease in the degree of utilization, suggesting that the criteria used in the model can help managers in the evaluation of these projects. (author)

  6. Black Hole on a Chip: Proposal for a Physical Realization of the Sachdev-Ye-Kitaev model in a Solid-State System

    Directory of Open Access Journals (Sweden)

    D. I. Pikulin

    2017-07-01

    Full Text Available A system of Majorana zero modes with random infinite-range interactions—the Sachdev-Ye-Kitaev (SYK model—is thought to exhibit an intriguing relation to the horizons of extremal black holes in two-dimensional anti–de Sitter space. This connection provides a rare example of holographic duality between a solvable quantum-mechanical model and dilaton gravity. Here, we propose a physical realization of the SYK model in a solid-state system. The proposed setup employs the Fu-Kane superconductor realized at the interface between a three-dimensional topological insulator and an ordinary superconductor. The requisite N Majorana zero modes are bound to a nanoscale hole fabricated in the superconductor that is threaded by N quanta of magnetic flux. We show that when the system is tuned to the surface neutrality point (i.e., chemical potential coincident with the Dirac point of the topological insulator surface state and the hole has sufficiently irregular shape, the Majorana zero modes are described by the SYK Hamiltonian. We perform extensive numerical simulations to demonstrate that the system indeed exhibits physical properties expected of the SYK model, including thermodynamic quantities and two-point as well as four-point correlators, and discuss ways in which these can be observed experimentally.

  7. Adiposity, Dysmetabolic Traits, and Earlier Onset of Female Puberty in Adolescent Offspring of Women With Gestational Diabetes Mellitus: A Clinical Study Within the Danish National Birth Cohort

    DEFF Research Database (Denmark)

    Grunnet, L. G.; Hansen, S.; Hjort, L.

    2017-01-01

    and associated cardiometabolic traits in 561 9- to 16-year-old offspring of mothers with GDM and 597 control offspring. RESEARCH DESIGN AND METHODS: We measured anthropometric characteristics; puberty status; blood pressure; and fasting glucose, insulin, C-peptide, and lipid levels; and conducted a DEXA scan...... in a subset of the cohort. Differences in the outcomes between offspring of mothers with GDM and control subjects were examined using linear and logistic regression models. RESULTS: After adjustment for age and sex, offspring of mothers with GDM displayed higher weight, BMI, waist-to-hip ratio (WHR), systolic...... glucose, insulin, C-peptide, HOMA-insulin resistance (IR), and plasma triglyceride levels, whereas fasting plasma HDL cholesterol levels were decreased. Female offspring of mothers with GDM had an earlier onset of puberty than control offspring. Offspring of mothers with GDM had significantly higher BMI...

  8. Making sense of resilience: a review from the field of paediatric psycho-oncology and a proposal of a model for its study

    Directory of Open Access Journals (Sweden)

    Carmina Castellano-Tejedor

    2014-10-01

    Full Text Available This article is intended to review the concept of resilience from the scope of paediatric psycho-oncology. The origin, its different definitions and its suitability of application in the field of serious physical illness - such as cancer - will be analyzed. Furthermore, the differences between resilience and other concepts commonly associated or confused with it, such as post-traumatic growth or benefit finding, will be discussed. Finally, a proposal for a comprehensive model of resilience in paediatric cancer will be put forward.

  9. Model for lattice dynamics of hexagonal close packed metals

    Energy Technology Data Exchange (ETDEWEB)

    Singh, R K [Tata Inst. of Fundamental Research, Bombay (India); Kumar, S [Meerut Coll. (India). Dept. of Physics

    1977-11-19

    A lattice dynamical model, which satisfies the requirements of translational invariance as well as the static equilibrium of hexagonal close packed lattice, has been proposed and applied to study the phonon dispersion relations in magnesium. The results revealed by this model have been claimed to be better than earlier ones.

  10. Earlier Age of Onset of Chronic Hypertension and Type 2 Diabetes Mellitus After a Hypertensive Disorder of Pregnancy or Gestational Diabetes Mellitus.

    Science.gov (United States)

    Heida, Karst Y; Franx, Arie; van Rijn, Bas B; Eijkemans, Marinus J C; Boer, Jolanda M A; Verschuren, Monique W M; Oudijk, Martijn A; Bots, Michiel L; van der Schouw, Yvonne T

    2015-12-01

    A prospective cohort study was conducted to assess the impact of a history of hypertensive disorder of pregnancy (HDP) or gestational diabetes mellitus (GDM) on the risk and age of onset of hypertension, type 2 diabetes mellitus (T2D), and cardiovascular disease (CVD) later in life, independent of hypertension and T2D. Between 1993 and 1997, 22 265 ever-pregnant women were included from the European Prospective Investigation into Cancer and Nutrition-NL study, aged 20 to 70 years at baseline. Details on complications of pregnancy and known hypertension were obtained by questionnaire. Blood pressure was measured at enrollment. Participants were followed for the occurrence of CVD events. Data were analyzed using ANCOVA, multivariable logistic regression, and Cox proportional hazard (with HDP and GDM as time-dependent variables for T2D and CVD) models. At enrollment, women with a HDP reported diagnosis of hypertension 7.7 years earlier (95% confidence interval [CI] 6.9-8.5) and women with GDM reported diagnosis of T2D 7.7 years earlier (95% CI 5.8-9.6) than women without pregnancy complications. After adjustment for potential confounders, HDP was associated with presence of hypertension at enrollment (odds ratio 2.12, 95% CI 1.98-2.28) and onset of CVD later in life (hazard ratio 1.21, 95% CI 1.10-1.32). After including the intermediates hypertension and T2D in the model, the risk of CVD later in life decreased (hazard ratio 1.09, 95% CI 1.00-1.20). GDM was associated with an increased risk of developing T2D later in life (hazard ratio 3.68, 95% CI 2.77-4.90), but not with risk of CVD. HDP and GDM have a substantial impact on the risk of CVD and are potentially important indicators for preventive cardiovascular risk management. © 2015 American Heart Association, Inc.

  11. Implementation of a Proposed Model of a Constructivist Teaching-Learning Process – A Step Towards an Outcome Based Education in Chemistry Laboratory Instruction

    Directory of Open Access Journals (Sweden)

    Dr. Paz B. Reyes

    2013-12-01

    Full Text Available This study implemented the proposed model of a constructivist teachinglearning process and determined the extent by which the students manifested the institutional learning outcomes which include competency, credibility, commitment and collaboration. It also investigated if there was an improvement in the learning outcomes after the implementation of the constructivist teachinglearning process and determined the students’ acceptance of the constructivist teaching-learning process. Towards the end a plan of action was proposed to enhance the students’ manifestation of the institutional learning outcomes. It made use of the qualitative- quantitative method particularly the descriptive design. The results of the study revealed that the students manifest competency, credibility, commitment and collaboration as they accept positively the constructivist teaching-learning process in their chemistry laboratory subject. It can be deduced from the findings that the constructivist teaching-learning process improved the learning outcomes of the students. The use of the proposed plan of action is recommended for an effective chemistry laboratory instruction.

  12. A monograph proposing the use of canine mammary tumours as a model for the study of hereditary breast cancer susceptibility genes in humans.

    Science.gov (United States)

    Goebel, Katie; Merner, Nancy D

    2017-05-01

    Canines are excellent models for cancer studies due to their similar physiology and genomic sequence to humans, companion status and limited intra-breed heterogeneity. Due to their affliction to mammary cancers, canines can serve as powerful genetic models of hereditary breast cancers. Variants within known human breast cancer susceptibility genes only explain a fraction of familial cases. Thus, further discovery is necessary but such efforts have been thwarted by genetic heterogeneity. Reducing heterogeneity is key, and studying isolated human populations have helped in the endeavour. An alternative is to study dog pedigrees, since artificial selection has resulted in extreme homogeneity. Identifying the genetic predisposition to canine mammary tumours can translate to human discoveries - a strategy currently underutilized. To explore this potential, we reviewed published canine mammary tumour genetic studies and proposed benefits of next generation sequencing canine cohorts to facilitate moving beyond incremental advances.

  13. Social intelligence of parents with autism spectrum disorders impacts their emotional behaviour: A new proposed model for stabilising emotionality of these parents impacting their social intelligence

    Directory of Open Access Journals (Sweden)

    Vidya Bhagat

    2017-01-01

    Full Text Available Autism spectrum disorder (ASD may affect all spheres of a child's life. Indeed, parents and siblings also live with emotional instabilities in the family. The experience of parents with ASD child can be distressing since they need to make more adjustments to the demanding need to cope with their life situations. Perhaps, their life is drastically exaggerated with their complexities of life. Particularly, their social life is radically affected. The presence of pervasive and severe deficits in children with ASD isolates these parents from their social life; demanding adjustments to their social environment of parents in their life situations shove them into distress and unstable emotions. Finally, they culminate being shattered in their interpersonal relationship, their family and social life. Indeed, these aspects of distress mask social intelligence of these parents, thus narrow down their focus more on the treatment rather than holistic management of their child. Thus, the management of ASD with these parents of the deficit children to reach their fullest abilities remains doubtful. Therefore, the objectives of this study are as follows: (a to examine the impact of emotionality on social intelligence of parents blessed with autistic child, (b to develop awareness regarding social intelligence and its significance among these parents, (c to propose a new model stabilising emotionality of these parents through developing social adaption skills and (d to suggest a new model as a guide in the current intervention regimens to ensure the emotional well-being and better social adoption. This study is made based on the keenly examined past evidence with the correlation of emotionality and its impact on social intelligence of the parents with ASD children. The results reveal that the social intelligence is perceived as lowered evidenced by poor social adjustment reflected in social isolation observed in the parents of children with ASD. A new model

  14. Best practices for system dynamics model design and construction with powersim studio.

    Energy Technology Data Exchange (ETDEWEB)

    Malczynski, Leonard A.

    2011-06-01

    This guide addresses software quality in the construction of Powersim{reg_sign} Studio 8 system dynamics simulation models. It is the result of almost ten years of experience with the Powersim suite of system dynamics modeling tools (Constructor and earlier Studio versions). It is a guide that proposes a common look and feel for the construction of Powersim Studio system dynamics models.

  15. Physical optics modeling of modal patterns in a crossed porro prism resonator

    CSIR Research Space (South Africa)

    Litvin, IA

    2006-07-01

    Full Text Available A physical optics model is proposed to describe the transverse modal patterns in crossed Porro prism resonators. The model departs from earlier attempts in that the prisms are modeled as non-classical rotating elements with amplitude and phase...

  16. Model-based development and testing of advertising messages: A comparative study of two campaign proposals based on the MECCAS model and a conventional approach

    DEFF Research Database (Denmark)

    Bech-Larsen, Tino

    theoretically valid and comprehensible guidelines for message development potentially enhances the effects of advertising messages and improves the possibility of measuring such effects. Moreover, such guidelines also have potential implications for the managerial communication processes (client......1. Traditionally the development of advertising messages has been based on "creative independence", sometimes catalysed by inductively generated empirical data. Due to the recent intensified focus on advertising effectiveness, this state of affair is now beginning to change. 2. Implementing......-agency and intra-agency) involved in the development of advertising messages. 3. The purpose of the study described in this paper is to compare the development and effects of two campaign proposals, with the common aim of increasing the consumption of apples among young Danes (18 to 35 years of age). One...

  17. Insights of the periodic reviews regarding the physical protection of nuclear power plants designed to earlier standards

    International Nuclear Information System (INIS)

    Hagemann, A.

    2001-01-01

    Among other prerequisites for licensing a nuclear activity, the German Atomic Energy Act stipulates that the necessary physical protection against malevolent acts has to be approved before granting a license. This is required for nuclear power plants in paragraph 7 of the Atomic Energy Act. The licenses for nuclear power plants designed to earlier standards were granted about 20 years ago and more. All NPPs are under the supervision of the Supervisory Authority in order to ensure that all conditions of the license are met during the whole plant operation period. The 'Periodic Safety Review', PSR, is designated to provide the Supervisory Authority with additional information on the safety status. One part of the PSR is the 'Deterministic Security Analysis', DSA. The subject of the DSA is the actual physical protection of a NPP. The following document outlines the experiences gained during the evaluation of DSA reports by GRS as an external expert organisation under contract of the Supervisory Authorities. (author)

  18. Association of Previous Clinical Breast Examination With Reduced Delays and Earlier-Stage Breast Cancer Diagnosis Among Women in Peru.

    Science.gov (United States)

    Romanoff, Anya; Constant, Tara Hayes; Johnson, Kay M; Guadiamos, Manuel Cedano; Vega, Ana María Burga; Zunt, Joseph; Anderson, Benjamin O

    2017-11-01

    Mammographic screening is impractical in most of the world where breast cancers are first identified based on clinical signs and symptoms. Clinical breast examination may improve early diagnosis directly by finding breast cancers at earlier stages or indirectly by heightening women's awareness of breast health concerns. To investigate factors that influence time to presentation and stage at diagnosis among patients with breast cancer to determine whether history of previous clinical breast examination is associated with earlier presentation and/or earlier cancer stage at diagnosis. In this cross-sectional analysis of individual patient interviews using a validated Breast Cancer Delay Questionnaire, 113 (71.1%) of 159 women with breast cancer treated at a federally funded tertiary care referral cancer center in Trujillo, Peru, from February 1 through May 31, 2015, were studied. Method of breast cancer detection and factors that influence time to and stage at diagnosis. Of 113 women with diagnosed cancer (mean [SD] age, 54 [10.8] years; age range, 32-82 years), 105 (92.9%) had self-detected disease. Of the 93 women for whom stage was documented, 45 (48.4%) were diagnosed with early-stage disease (American Joint Committee on Cancer [AJCC] stage 0, I, or II), and 48 (51.6%) were diagnosed with late-stage disease (AJCC stage III or IV). Mean (SD) total delay from symptom onset to initiation of treatment was 407 (665) days because of patient (mean [SD], 198 [449] days) and health care system (mean [SD], 241 [556] days) delay. Fifty-two women (46.0%) had a history of clinical breast examination, and 23 (20.4%) had undergone previous mammography. Women who underwent a previous clinical breast examination were more likely to have shorter delays from symptom development to presentation compared with women who had never undergone a previous clinical breast examination (odds ratio, 2.92; 95% CI, 1.30-6.60; P = .01). Women diagnosed with shorter patient delay were more

  19. Low protein content of drainage fluid is a good predictor for earlier chest tube removal after lobectomy.

    Science.gov (United States)

    Olgac, Guven; Cosgun, Tugba; Vayvada, Mustafa; Ozdemir, Atilla; Kutlu, Cemal Asim

    2014-10-01

    Owing to the great absorption capability of the pleura for transudates, the protein content of draining pleural fluid may be considered as a more adequate determinant than its daily draining amount in the decision-making for earlier chest tube removal. In an a priori pilot study, we observed that the initially draining protein-rich exudate converts to a transudate quickly in most patients after lobectomies. Thus, chest tubes draining high-volume but low-protein fluids can safely be removed earlier in the absence of an air leak. This randomized study aims to investigate the validity and clinical applicability of this hypothesis as well as its influence on the timing for chest tube removal and earlier discharge after lobectomy. Seventy-two consecutive patients undergoing straightforward lobectomy were randomized into two groups. Patients with conditions affecting postoperative drainage and with persisting air leaks beyond the third postoperative day were excluded. Drains were removed if the pleural fluid to blood protein ratio (PrRPl/B) was ≤0.5, regardless of its daily draining amount in the study arm (Group S; n = 38), and patients in the control arm (Group C; n = 34) had their tubes removed if daily drainage was ≤250 ml regardless of its protein content. Patients were discharged home immediately or the following morning after removal of the last drain. All cases were followed up regarding the development of symptomatic pleural effusions and hospital readmissions for a redrainage procedure. Demographic and clinical characteristics as well as the pattern of decrease in PrRPl/B were the same between groups. The mean PrRPl/B was 0.65 and 0.67 (95% CI = 0.60-0.69 and 0.62-0.72) on the first postoperative day, and it remarkably dropped down to 0.39 and 0.33 (95% CI = 0.33-0.45 and 0.27-0.39) on the second day in Groups S and C, respectively, and remained below 0.5 on the third day (repeated-measures of ANOVA design, post hoc 'within-group' comparison of the first

  20. Complementary functions of the two brain hemispheres: comparisons with earlier conceptions and implications for individual and society.

    Science.gov (United States)

    Zeier, H

    1989-07-01

    The concept of different functions for the left and right cerebral hemispheres coincides in an astonishing way with earlier philosophical and psychological work which divided the human mind into two complementary functions without having a neurophysiological explanation. Representative are the ideas of Fichte, Hegel and Jung. The latter postulated the two subsystems Ego and Self and associated the conscious functions of the Ego with the intellect, the capacity for rational thought, and the Self with the mind, which also includes the emotional feelings. For the harmonic development and self-realization of man the functions of both systems in complementary interaction are required. Therefore, the current overaccentuation of the intellect and of progress directed technical-scientific thinking should be corrected by making better use of the much neglected functions of the right hemisphere.