WorldWideScience

Sample records for model include normal

  1. The Benefits of Including Clinical Factors in Rectal Normal Tissue Complication Probability Modeling After Radiotherapy for Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Defraene, Gilles, E-mail: gilles.defraene@uzleuven.be [Radiation Oncology Department, University Hospitals Leuven, Leuven (Belgium); Van den Bergh, Laura [Radiation Oncology Department, University Hospitals Leuven, Leuven (Belgium); Al-Mamgani, Abrahim [Department of Radiation Oncology, Erasmus Medical Center - Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Haustermans, Karin [Radiation Oncology Department, University Hospitals Leuven, Leuven (Belgium); Heemsbergen, Wilma [Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Van den Heuvel, Frank [Radiation Oncology Department, University Hospitals Leuven, Leuven (Belgium); Lebesque, Joos V. [Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)

    2012-03-01

    Purpose: To study the impact of clinical predisposing factors on rectal normal tissue complication probability modeling using the updated results of the Dutch prostate dose-escalation trial. Methods and Materials: Toxicity data of 512 patients (conformally treated to 68 Gy [n = 284] and 78 Gy [n = 228]) with complete follow-up at 3 years after radiotherapy were studied. Scored end points were rectal bleeding, high stool frequency, and fecal incontinence. Two traditional dose-based models (Lyman-Kutcher-Burman (LKB) and Relative Seriality (RS) and a logistic model were fitted using a maximum likelihood approach. Furthermore, these model fits were improved by including the most significant clinical factors. The area under the receiver operating characteristic curve (AUC) was used to compare the discriminating ability of all fits. Results: Including clinical factors significantly increased the predictive power of the models for all end points. In the optimal LKB, RS, and logistic models for rectal bleeding and fecal incontinence, the first significant (p = 0.011-0.013) clinical factor was 'previous abdominal surgery.' As second significant (p = 0.012-0.016) factor, 'cardiac history' was included in all three rectal bleeding fits, whereas including 'diabetes' was significant (p = 0.039-0.048) in fecal incontinence modeling but only in the LKB and logistic models. High stool frequency fits only benefitted significantly (p = 0.003-0.006) from the inclusion of the baseline toxicity score. For all models rectal bleeding fits had the highest AUC (0.77) where it was 0.63 and 0.68 for high stool frequency and fecal incontinence, respectively. LKB and logistic model fits resulted in similar values for the volume parameter. The steepness parameter was somewhat higher in the logistic model, also resulting in a slightly lower D{sub 50}. Anal wall DVHs were used for fecal incontinence, whereas anorectal wall dose best described the other two endpoints

  2. Analysis of shallow-water experimental acoustic data including a comparison with a broad-band normal-mode-propagation model

    NARCIS (Netherlands)

    Simons, D.G.; McHugh, R.; Snellen, M.; McCormick, N.H.; Lawson, E.A.

    2001-01-01

    Channel temporal variability, resulting from fluctuations in oceanographic parameters, is an important issue for reliable communications in shallow-water-long-range acoustic propagation. As part of an acoustic model validation exercise, audio-band acoustic data and oceanographic data were collected

  3. Including Magnetostriction in Micromagnetic Models

    Science.gov (United States)

    Conbhuí, Pádraig Ó.; Williams, Wyn; Fabian, Karl; Nagy, Lesleis

    2016-04-01

    The magnetic anomalies that identify crustal spreading are predominantly recorded by basalts formed at the mid-ocean ridges, whose magnetic signals are dominated by iron-titanium-oxides (Fe3-xTixO4), so called "titanomagnetites", of which the Fe2.4Ti0.6O4 (TM60) phase is the most common. With sufficient quantities of titanium present, these minerals exhibit strong magnetostriction. To date, models of these grains in the pseudo-single domain (PSD) range have failed to accurately account for this effect. In particular, a popular analytic treatment provided by Kittel (1949) for describing the magnetostrictive energy as an effective increase of the anisotropy constant can produce unphysical strains for non-uniform magnetizations. I will present a rigorous approach based on work by Brown (1966) and by Kroner (1958) for including magnetostriction in micromagnetic codes which is suitable for modelling hysteresis loops and finding remanent states in the PSD regime. Preliminary results suggest the more rigorously defined micromagnetic models exhibit higher coercivities and extended single domain ranges when compared to more simplistic approaches.

  4. Inequality constrained normal linear models

    NARCIS (Netherlands)

    Klugkist, I.G.

    2005-01-01

    This dissertation deals with normal linear models with inequality constraints among model parameters. It consists of an introduction and four chapters that are papers submitted for publication. The first chapter introduces the use of inequality constraints. Scientists often have one or more theories

  5. Relativistic calculation of nuclear magnetic shielding tensor using the regular approximation to the normalized elimination of the small component. III. Introduction of gauge-including atomic orbitals and a finite-size nuclear model

    Science.gov (United States)

    Hamaya, S.; Maeda, H.; Funaki, M.; Fukui, H.

    2008-12-01

    The relativistic calculation of nuclear magnetic shielding tensors in hydrogen halides is performed using the second-order regular approximation to the normalized elimination of the small component (SORA-NESC) method with the inclusion of the perturbation terms from the metric operator. This computational scheme is denoted as SORA-Met. The SORA-Met calculation yields anisotropies, Δσ =σ∥-σ⊥, for the halogen nuclei in hydrogen halides that are too small. In the NESC theory, the small component of the spinor is combined to the large component via the operator σ⃗ṡπ⃗U/2c, in which π⃗=p⃗+A⃗, U is a nonunitary transformation operator, and c ≅137.036 a.u. is the velocity of light. The operator U depends on the vector potential A⃗ (i.e., the magnetic perturbations in the system) with the leading order c-2 and the magnetic perturbation terms of U contribute to the Hamiltonian and metric operators of the system in the leading order c-4. It is shown that the small Δσ for halogen nuclei found in our previous studies is related to the neglect of the U(0,1) perturbation operator of U, which is independent of the external magnetic field and of the first order with respect to the nuclear magnetic dipole moment. Introduction of gauge-including atomic orbitals and a finite-size nuclear model is also discussed.

  6. Normalization of Gravitational Acceleration Models

    Science.gov (United States)

    Eckman, Randy A.; Brown, Aaron J.; Adamo, Daniel R.

    2011-01-01

    Unlike the uniform density spherical shell approximations of Newton, the con- sequence of spaceflight in the real universe is that gravitational fields are sensitive to the nonsphericity of their generating central bodies. The gravitational potential of a nonspherical central body is typically resolved using spherical harmonic approximations. However, attempting to directly calculate the spherical harmonic approximations results in at least two singularities which must be removed in order to generalize the method and solve for any possible orbit, including polar orbits. Three unique algorithms have been developed to eliminate these singularities by Samuel Pines [1], Bill Lear [2], and Robert Gottlieb [3]. This paper documents the methodical normalization of two1 of the three known formulations for singularity-free gravitational acceleration (namely, the Lear [2] and Gottlieb [3] algorithms) and formulates a general method for defining normalization parameters used to generate normalized Legendre Polynomials and ALFs for any algorithm. A treatment of the conventional formulation of the gravitational potential and acceleration is also provided, in addition to a brief overview of the philosophical differences between the three known singularity-free algorithms.

  7. DEVELOPMENT OF WATER CIRCULATION MODEL INCLUDING IRRIGATION

    Science.gov (United States)

    Kotsuki, Shunji; Tanaka, Kenji; Kojiri, Toshiharu; Hamaguchi, Toshio

    It is well known that since agricultural water withdrawal has much affect on water circulation system, accurate analysis of river discharge or water balance are difficult with less regard for it. In this study, water circulation model composed of land surface model and distributed runoff model is proposed at 10km 10km resolution. In this model, irrigation water, which is estimated with land surface model, is introduced to river discharge analysis. The model is applied to the Chao Phraya River in Thailand, and reproduced seasonal water balance. Additionally, the discharge on dry season simulated with the model is improved as a result of including irrigation. Since the model, which is basically developed from global data sets, simulated seasonal change of river discharge, it can be suggested that our model has university to other river basins.

  8. Models of bovine babesiosis including juvenile cattle.

    Science.gov (United States)

    Saad-Roy, C M; Shuai, Zhisheng; van den Driessche, P

    2015-03-01

    Bovine Babesiosis in cattle is caused by the transmission of protozoa of Babesia spp. by ticks as vectors. Juvenile cattle (Babesiosis, rarely show symptoms, and acquire immunity upon recovery. Susceptibility to the disease varies between breeds of cattle. Models of the dynamics of Bovine Babesiosis transmitted by the cattle tick that include these factors are formulated as systems of ordinary differential equations. Basic reproduction numbers are calculated, and it is proved that if these numbers are below the threshold value of one, then Bovine Babesiosis dies out. However, above the threshold number of one, the disease may approach an endemic state. In this case, control measures are suggested by determining target reproduction numbers. The percentage of a particular population (for example, the adult bovine population) needed to be controlled to eradicate the disease is evaluated numerically using Columbia data from the literature.

  9. A Skew-Normal Mixture Regression Model

    Science.gov (United States)

    Liu, Min; Lin, Tsung-I

    2014-01-01

    A challenge associated with traditional mixture regression models (MRMs), which rest on the assumption of normally distributed errors, is determining the number of unobserved groups. Specifically, even slight deviations from normality can lead to the detection of spurious classes. The current work aims to (a) examine how sensitive the commonly…

  10. An Integrated Biochemistry Laboratory, Including Molecular Modeling

    Science.gov (United States)

    Hall, Adele J. Wolfson Mona L.; Branham, Thomas R.

    1996-11-01

    ) experience with methods of protein purification; (iii) incorporation of appropriate controls into experiments; (iv) use of basic statistics in data analysis; (v) writing papers and grant proposals in accepted scientific style; (vi) peer review; (vii) oral presentation of results and proposals; and (viii) introduction to molecular modeling. Figure 1 illustrates the modular nature of the lab curriculum. Elements from each of the exercises can be separated and treated as stand-alone exercises, or combined into short or long projects. We have been able to offer the opportunity to use sophisticated molecular modeling in the final module through funding from an NSF-ILI grant. However, many of the benefits of the research proposal can be achieved with other computer programs, or even by literature survey alone. Figure 1.Design of project-based biochemistry laboratory. Modules (projects, or portions of projects) are indicated as boxes. Each of these can be treated independently, or used as part of a larger project. Solid lines indicate some suggested paths from one module to the next. The skills and knowledge required for protein purification and design are developed in three units: (i) an introduction to critical assays needed to monitor degree of purification, including an evaluation of assay parameters; (ii) partial purification by ion-exchange techniques; and (iii) preparation of a grant proposal on protein design by mutagenesis. Brief descriptions of each of these units follow, with experimental details of each project at the end of this paper. Assays for Lysozyme Activity and Protein Concentration (4 weeks) The assays mastered during the first unit are a necessary tool for determining the purity of the enzyme during the second unit on purification by ion exchange. These assays allow an introduction to the concept of specific activity (units of enzyme activity per milligram of total protein) as a measure of purity. In this first sequence, students learn a turbidimetric assay

  11. Seepage Model for PA Including Dift Collapse

    Energy Technology Data Exchange (ETDEWEB)

    G. Li; C. Tsang

    2000-12-20

    The purpose of this Analysis/Model Report (AMR) is to document the predictions and analysis performed using the Seepage Model for Performance Assessment (PA) and the Disturbed Drift Seepage Submodel for both the Topopah Spring middle nonlithophysal and lower lithophysal lithostratigraphic units at Yucca Mountain. These results will be used by PA to develop the probability distribution of water seepage into waste-emplacement drifts at Yucca Mountain, Nevada, as part of the evaluation of the long term performance of the potential repository. This AMR is in accordance with the ''Technical Work Plan for Unsaturated Zone (UZ) Flow and Transport Process Model Report'' (CRWMS M&O 2000 [153447]). This purpose is accomplished by performing numerical simulations with stochastic representations of hydrological properties, using the Seepage Model for PA, and evaluating the effects of an alternative drift geometry representing a partially collapsed drift using the Disturbed Drift Seepage Submodel. Seepage of water into waste-emplacement drifts is considered one of the principal factors having the greatest impact of long-term safety of the repository system (CRWMS M&O 2000 [153225], Table 4-1). This AMR supports the analysis and simulation that are used by PA to develop the probability distribution of water seepage into drift, and is therefore a model of primary (Level 1) importance (AP-3.15Q, ''Managing Technical Product Inputs''). The intended purpose of the Seepage Model for PA is to support: (1) PA; (2) Abstraction of Drift-Scale Seepage; and (3) Unsaturated Zone (UZ) Flow and Transport Process Model Report (PMR). Seepage into drifts is evaluated by applying numerical models with stochastic representations of hydrological properties and performing flow simulations with multiple realizations of the permeability field around the drift. The Seepage Model for PA uses the distribution of permeabilities derived from air injection testing in

  12. Enhanced battery model including temperature effects

    NARCIS (Netherlands)

    Rosca, B.; Wilkins, S.

    2013-01-01

    Within electric and hybrid vehicles, batteries are used to provide/buffer the energy required for driving. However, battery performance varies throughout the temperature range specific to automotive applications, and as such, models that describe this behaviour are required. This paper presents a dy

  13. Enhanced battery model including temperature effects

    NARCIS (Netherlands)

    Rosca, B.; Wilkins, S.

    2013-01-01

    Within electric and hybrid vehicles, batteries are used to provide/buffer the energy required for driving. However, battery performance varies throughout the temperature range specific to automotive applications, and as such, models that describe this behaviour are required. This paper presents a dy

  14. Enhanced battery model including temperature effects

    NARCIS (Netherlands)

    Rosca, B.; Wilkins, S.

    2013-01-01

    Within electric and hybrid vehicles, batteries are used to provide/buffer the energy required for driving. However, battery performance varies throughout the temperature range specific to automotive applications, and as such, models that describe this behaviour are required. This paper presents a

  15. Modeling heart rate variability including the effect of sleep stages

    Science.gov (United States)

    Soliński, Mateusz; Gierałtowski, Jan; Żebrowski, Jan

    2016-02-01

    We propose a model for heart rate variability (HRV) of a healthy individual during sleep with the assumption that the heart rate variability is predominantly a random process. Autonomic nervous system activity has different properties during different sleep stages, and this affects many physiological systems including the cardiovascular system. Different properties of HRV can be observed during each particular sleep stage. We believe that taking into account the sleep architecture is crucial for modeling the human nighttime HRV. The stochastic model of HRV introduced by Kantelhardt et al. was used as the initial starting point. We studied the statistical properties of sleep in healthy adults, analyzing 30 polysomnographic recordings, which provided realistic information about sleep architecture. Next, we generated synthetic hypnograms and included them in the modeling of nighttime RR interval series. The results of standard HRV linear analysis and of nonlinear analysis (Shannon entropy, Poincaré plots, and multiscale multifractal analysis) show that—in comparison with real data—the HRV signals obtained from our model have very similar properties, in particular including the multifractal characteristics at different time scales. The model described in this paper is discussed in the context of normal sleep. However, its construction is such that it should allow to model heart rate variability in sleep disorders. This possibility is briefly discussed.

  16. A normalization model of multisensory integration.

    Science.gov (United States)

    Ohshiro, Tomokazu; Angelaki, Dora E; DeAngelis, Gregory C

    2011-06-01

    Responses of neurons that integrate multiple sensory inputs are traditionally characterized in terms of a set of empirical principles. However, a simple computational framework that accounts for these empirical features of multisensory integration has not been established. We propose that divisive normalization, acting at the stage of multisensory integration, can account for many of the empirical principles of multisensory integration shown by single neurons, such as the principle of inverse effectiveness and the spatial principle. This model, which uses a simple functional operation (normalization) for which there is considerable experimental support, also accounts for the recent observation that the mathematical rule by which multisensory neurons combine their inputs changes with cue reliability. The normalization model, which makes a strong testable prediction regarding cross-modal suppression, may therefore provide a simple unifying computational account of the important features of multisensory integration by neurons.

  17. Modelling non-normal data : The relationship between the skew-normal factor model and the quadratic factor model

    NARCIS (Netherlands)

    Smits, Iris A.M.; Timmerman, Marieke E.; Stegeman, Alwin

    Maximum likelihood estimation of the linear factor model for continuous items assumes normally distributed item scores. We consider deviations from normality by means of a skew-normally distributed factor model or a quadratic factor model. We show that the item distributions under a skew-normal

  18. Image Retrieval and Classification Method Based on Euclidian Distance Between Normalized Features Including Wavelet Descriptor

    Directory of Open Access Journals (Sweden)

    Kohei Arai

    2013-10-01

    Full Text Available Image retrieval method based on Euclidian distance between normalized features with their mean and variance in feature space is proposed. Effectiveness of the normalization is evaluated together with a validation of the proposed image retrieval method. The proposed method is applied for discrimination and identifying dangerous red tide species based on wavelet utilized classification methods together with texture and color features. Through experiments, it is found that classification performance with the proposed wavelet derived shape information extracted from the microscopic view of the phytoplankton is effective for identifying dangerous red tide species among the other red tide species rather than the other conventional texture, color information. Moreover, it is also found that the proposed normalization of features is effective to improve identification performance.

  19. Modeling and simulation of normal and hemiparetic gait

    Science.gov (United States)

    Luengas, Lely A.; Camargo, Esperanza; Sanchez, Giovanni

    2015-09-01

    Gait is the collective term for the two types of bipedal locomotion, walking and running. This paper is focused on walking. The analysis of human gait is of interest to many different disciplines, including biomechanics, human-movement science, rehabilitation and medicine in general. Here we present a new model that is capable of reproducing the properties of walking, normal and pathological. The aim of this paper is to establish the biomechanical principles that underlie human walking by using Lagrange method. The constraint forces of Rayleigh dissipation function, through which to consider the effect on the tissues in the gait, are included. Depending on the value of the factor present in the Rayleigh dissipation function, both normal and pathological gait can be simulated. First of all, we apply it in the normal gait and then in the permanent hemiparetic gait. Anthropometric data of adult person are used by simulation, and it is possible to use anthropometric data for children but is necessary to consider existing table of anthropometric data. Validation of these models includes simulations of passive dynamic gait that walk on level ground. The dynamic walking approach provides a new perspective of gait analysis, focusing on the kinematics and kinetics of gait. There have been studies and simulations to show normal human gait, but few of them have focused on abnormal, especially hemiparetic gait. Quantitative comparisons of the model predictions with gait measurements show that the model can reproduce the significant characteristics of normal gait.

  20. Characterization of normality of chaotic systems including prediction and detection of anomalies

    Science.gov (United States)

    Engler, Joseph John

    Accurate prediction and control pervades domains such as engineering, physics, chemistry, and biology. Often, it is discovered that the systems under consideration cannot be well represented by linear, periodic nor random data. It has been shown that these systems exhibit deterministic chaos behavior. Deterministic chaos describes systems which are governed by deterministic rules but whose data appear to be random or quasi-periodic distributions. Deterministically chaotic systems characteristically exhibit sensitive dependence upon initial conditions manifested through rapid divergence of states initially close to one another. Due to this characterization, it has been deemed impossible to accurately predict future states of these systems for longer time scales. Fortunately, the deterministic nature of these systems allows for accurate short term predictions, given the dynamics of the system are well understood. This fact has been exploited in the research community and has resulted in various algorithms for short term predictions. Detection of normality in deterministically chaotic systems is critical in understanding the system sufficiently to able to predict future states. Due to the sensitivity to initial conditions, the detection of normal operational states for a deterministically chaotic system can be challenging. The addition of small perturbations to the system, which may result in bifurcation of the normal states, further complicates the problem. The detection of anomalies and prediction of future states of the chaotic system allows for greater understanding of these systems. The goal of this research is to produce methodologies for determining states of normality for deterministically chaotic systems, detection of anomalous behavior, and the more accurate prediction of future states of the system. Additionally, the ability to detect subtle system state changes is discussed. The dissertation addresses these goals by proposing new representational

  1. Modelling non-normal data: The relationship between the skew-normal factor model and the quadratic factor model.

    Science.gov (United States)

    Smits, Iris A M; Timmerman, Marieke E; Stegeman, Alwin

    2016-05-01

    Maximum likelihood estimation of the linear factor model for continuous items assumes normally distributed item scores. We consider deviations from normality by means of a skew-normally distributed factor model or a quadratic factor model. We show that the item distributions under a skew-normal factor are equivalent to those under a quadratic model up to third-order moments. The reverse only holds if the quadratic loadings are equal to each other and within certain bounds. We illustrate that observed data which follow any skew-normal factor model can be so well approximated with the quadratic factor model that the models are empirically indistinguishable, and that the reverse does not hold in general. The choice between the two models to account for deviations of normality is illustrated by an empirical example from clinical psychology. © 2015 The British Psychological Society.

  2. Kinetic models of gene expression including non-coding RNAs

    Science.gov (United States)

    Zhdanov, Vladimir P.

    2011-03-01

    In cells, genes are transcribed into mRNAs, and the latter are translated into proteins. Due to the feedbacks between these processes, the kinetics of gene expression may be complex even in the simplest genetic networks. The corresponding models have already been reviewed in the literature. A new avenue in this field is related to the recognition that the conventional scenario of gene expression is fully applicable only to prokaryotes whose genomes consist of tightly packed protein-coding sequences. In eukaryotic cells, in contrast, such sequences are relatively rare, and the rest of the genome includes numerous transcript units representing non-coding RNAs (ncRNAs). During the past decade, it has become clear that such RNAs play a crucial role in gene expression and accordingly influence a multitude of cellular processes both in the normal state and during diseases. The numerous biological functions of ncRNAs are based primarily on their abilities to silence genes via pairing with a target mRNA and subsequently preventing its translation or facilitating degradation of the mRNA-ncRNA complex. Many other abilities of ncRNAs have been discovered as well. Our review is focused on the available kinetic models describing the mRNA, ncRNA and protein interplay. In particular, we systematically present the simplest models without kinetic feedbacks, models containing feedbacks and predicting bistability and oscillations in simple genetic networks, and models describing the effect of ncRNAs on complex genetic networks. Mathematically, the presentation is based primarily on temporal mean-field kinetic equations. The stochastic and spatio-temporal effects are also briefly discussed.

  3. Assessing the Comprehensive Seismic Earth Model using normal mode data

    Science.gov (United States)

    Koelemeijer, Paula; Afanasiev, Michael; Fichtner, Andreas; Gokhberg, Alexey

    2016-04-01

    Advances in computational resources and numerical methods allow the simulation of realistic seismic wave propagation through complex media, while ensuring that the complete wave field is correctly represented in synthetic seismograms. This full waveform inversion is widely applied on regional and continental scales, where particularly dense data sampled can be achieved leading to an increased resolution in the obtained model images. On a global scale, however, full waveform tomography is still and will continue to be limited to longer length scales due to the large computational costs. Normal mode tomography provides an alternative fast full waveform approach for imaging seismic structures in a global way. Normal modes are not limited by the poor station-earthquake distribution and provide sensitivity to density structure. Using normal modes, a more robust long wavelength background model can be obtained, leading to more accurate absolute velocity models for tectonic and mineral physics interpretations. In addition, it is vital to combine all seismic data types across accessible periods to obtain a more complete, consistent and interpretable image of the Earth's interior. Here, we aim to combine the globally sensitive long period normal modes with shorter period full waveform modelling within the multi-scale framework of the Comprehensive Seismic Earth Model (CSEM). The multi-scale inversion framework of the CSEM allows exploitation of the full waveform capacity on both sides of the seismic spectrum. As the CSEM includes high-resolution subregions with velocity variations at much shorter wavelengths than normal modes could constrain, the question arises whether these small-scale variations are noticeable in normal mode data, and which modes respond in particular. We report here on experiments in which we address these questions. We separately investigate the effects of small-scale variations in shear-wave velocity and compressional wave velocity compared to the

  4. Dynamic hysteresis modeling including skin effect using diffusion equation model

    Science.gov (United States)

    Hamada, Souad; Louai, Fatima Zohra; Nait-Said, Nasreddine; Benabou, Abdelkader

    2016-07-01

    An improved dynamic hysteresis model is proposed for the prediction of hysteresis loop of electrical steel up to mean frequencies, taking into account the skin effect. In previous works, the analytical solution of the diffusion equation for low frequency (DELF) was coupled with the inverse static Jiles-Atherton (JA) model in order to represent the hysteresis behavior for a lamination. In the present paper, this approach is improved to ensure the reproducibility of measured hysteresis loops at mean frequency. The results of simulation are compared with the experimental ones. The selected results for frequencies 50 Hz, 100 Hz, 200 Hz and 400 Hz are presented and discussed.

  5. Dynamic hysteresis modeling including skin effect using diffusion equation model

    Energy Technology Data Exchange (ETDEWEB)

    Hamada, Souad, E-mail: souadhamada@yahoo.fr [LSP-IE: Research Laboratory, Electrical Engineering Department, University of Batna, 05000 Batna (Algeria); Louai, Fatima Zohra, E-mail: fz_louai@yahoo.com [LSP-IE: Research Laboratory, Electrical Engineering Department, University of Batna, 05000 Batna (Algeria); Nait-Said, Nasreddine, E-mail: n_naitsaid@yahoo.com [LSP-IE: Research Laboratory, Electrical Engineering Department, University of Batna, 05000 Batna (Algeria); Benabou, Abdelkader, E-mail: Abdelkader.Benabou@univ-lille1.fr [L2EP, Université de Lille1, 59655 Villeneuve d’Ascq (France)

    2016-07-15

    An improved dynamic hysteresis model is proposed for the prediction of hysteresis loop of electrical steel up to mean frequencies, taking into account the skin effect. In previous works, the analytical solution of the diffusion equation for low frequency (DELF) was coupled with the inverse static Jiles-Atherton (JA) model in order to represent the hysteresis behavior for a lamination. In the present paper, this approach is improved to ensure the reproducibility of measured hysteresis loops at mean frequency. The results of simulation are compared with the experimental ones. The selected results for frequencies 50 Hz, 100 Hz, 200 Hz and 400 Hz are presented and discussed.

  6. Unsteady panel method for complex configurations including wake modeling

    CSIR Research Space (South Africa)

    Van Zyl, Lourens H

    2008-01-01

    Full Text Available implementations of the DLM are however not very versatile in terms of geometries that can be modeled. The ZONA6 code offers a versatile surface panel body model including a separated wake model, but uses a pressure panel method for lifting surfaces. This paper...

  7. Modeling Electric Double-Layers Including Chemical Reaction Effects

    DEFF Research Database (Denmark)

    Paz-Garcia, Juan Manuel; Johannesson, Björn; Ottosen, Lisbeth M.

    2014-01-01

    A physicochemical and numerical model for the transient formation of an electric double-layer between an electrolyte and a chemically-active flat surface is presented, based on a finite elements integration of the nonlinear Nernst-Planck-Poisson model including chemical reactions. The model works...

  8. Circuit Modeling of a MEMS Varactor Including Dielectric Charging Dynamics

    Science.gov (United States)

    Giounanlis, P.; Andrade-Miceli, D.; Gorreta, S.; Pons-Nin, J.; Dominguez-Pumar, M.; Blokhina, E.

    2016-10-01

    Electrical models for MEMS varactors including the effect of dielectric charging dynamics are not available in commercial circuit simulators. In this paper a circuit model using lumped ideal elements available in the Cadence libraries and a basic Verilog-A model, has been implemented. The model has been used to simulate the dielectric charging in function of time and its effects over the MEMS capacitance value.

  9. Including investment risk in large-scale power market models

    DEFF Research Database (Denmark)

    Lemming, Jørgen Kjærgaard; Meibom, P.

    2003-01-01

    can be included in large-scale partial equilibrium models of the power market. The analyses are divided into a part about risk measures appropriate for power market investors and a more technical part about the combination of a risk-adjustment model and a partial-equilibrium model. To illustrate......Long-term energy market models can be used to examine investments in production technologies, however, with market liberalisation it is crucial that such models include investment risks and investor behaviour. This paper analyses how the effect of investment risk on production technology selection...... the analyses quantitatively, a framework based on an iterative interaction between the equilibrium model and a separate risk-adjustment module was constructed. To illustrate the features of the proposed modelling approach we examined how uncertainty in demand and variable costs affects the optimal choice...

  10. Normal forms for reduced stochastic climate models

    NARCIS (Netherlands)

    Majda, A.J.; Franzke, C.; Crommelin, D.T.

    The systematic development of reduced low-dimensional stochastic climate models from observations or comprehensive highdimensional climate models is an important topic for atmospheric low-frequency variability, climate sensitivity, and improved extended range forecasting. Here techniques from

  11. DYNAMIC BAYESIAN MODEL FOR A TRUNCATED NORMAL

    OpenAIRE

    1993-01-01

    Nesta tese desenvolvemos um Modelo Dinâmico Bayesiano para a densidade Normal Truncada. A estimação clássica e estática de observações desta densidade foi desenvolvida por A.C. Cohen nas décadas de 1950 e 1960, enquanto R. C. Souza apresentou, em 1978, um modelo dinâmico Bayesiano para esta densidade, no qual utilizava idéias da Teoria de Informação. O presente trabalho estende a formulação dinâmica Bayesiana de West, Harrinson e Migon por tratar de observações...

  12. Progressive IRP Models for Power Resources Including EPP

    Directory of Open Access Journals (Sweden)

    Yiping Zhu

    2017-01-01

    Full Text Available In the view of optimizing regional power supply and demand, the paper makes effective planning scheduling of supply and demand side resources including energy efficiency power plant (EPP, to achieve the target of benefit, cost, and environmental constraints. In order to highlight the characteristics of different supply and demand resources in economic, environmental, and carbon constraints, three planning models with progressive constraints are constructed. Results of three models by the same example show that the best solutions to different models are different. The planning model including EPP has obvious advantages considering pollutant and carbon emission constraints, which confirms the advantages of low cost and emissions of EPP. The construction of progressive IRP models for power resources considering EPP has a certain reference value for guiding the planning and layout of EPP within other power resources and achieving cost and environmental objectives.

  13. A hydrodynamic model for granular material flows including segregation effects

    Science.gov (United States)

    Gilberg, Dominik; Klar, Axel; Steiner, Konrad

    2017-06-01

    The simulation of granular flows including segregation effects in large industrial processes using particle methods is accurate, but very time-consuming. To overcome the long computation times a macroscopic model is a natural choice. Therefore, we couple a mixture theory based segregation model to a hydrodynamic model of Navier-Stokes-type, describing the flow behavior of the granular material. The granular flow model is a hybrid model derived from kinetic theory and a soil mechanical approach to cover the regime of fast dilute flow, as well as slow dense flow, where the density of the granular material is close to the maximum packing density. Originally, the segregation model has been formulated by Thornton and Gray for idealized avalanches. It is modified and adapted to be in the preferred form for the coupling. In the final coupled model the segregation process depends on the local state of the granular system. On the other hand, the granular system changes as differently mixed regions of the granular material differ i.e. in the packing density. For the modeling process the focus lies on dry granular material flows of two particle types differing only in size but can be easily extended to arbitrary granular mixtures of different particle size and density. To solve the coupled system a finite volume approach is used. To test the model the rotational mixing of small and large particles in a tumbler is simulated.

  14. Nonlinear and Non Normal Regression Models in Physiological Research

    OpenAIRE

    1984-01-01

    Applications of nonlinear and non normal regression models are in increasing order for appropriate interpretation of complex phenomenon of biomedical sciences. This paper reviews critically some applications of these models physiological research.

  15. Synaptic channel model including effects of spike width variation

    OpenAIRE

    2015-01-01

    Synaptic Channel Model Including Effects of Spike Width Variation Hamideh Ramezani Next-generation and Wireless Communications Laboratory (NWCL) Department of Electrical and Electronics Engineering Koc University, Istanbul, Turkey Ozgur B. Akan Next-generation and Wireless Communications Laboratory (NWCL) Department of Electrical and Electronics Engineering Koc University, Istanbul, Turkey ABSTRACT An accu...

  16. A sonic boom propagation model including mean flow atmospheric effects

    Science.gov (United States)

    Salamone, Joe; Sparrow, Victor W.

    2012-09-01

    This paper presents a time domain formulation of nonlinear lossy propagation in onedimension that also includes the effects of non-collinear mean flow in the acoustic medium. The model equation utilized is an augmented Burgers equation that includes the effects of nonlinearity, geometric spreading, atmospheric stratification, and also absorption and dispersion due to thermoviscous and molecular relaxation effects. All elements of the propagation are implemented in the time domain and the effects of non-collinear mean flow are accounted for in each term of the model equation. Previous authors have presented methods limited to showing the effects of wind on ray tracing and/or using an effective speed of sound in their model equation. The present work includes the effects of mean flow for all terms included in the augmented Burgers equation with all of the calculations performed in the time-domain. The capability to include the effects of mean flow in the acoustic medium allows one to make predictions more representative of real-world atmospheric conditions. Examples are presented for nonlinear propagation of N-waves and shaped sonic booms. [Work supported by Gulfstream Aerospace Corporation.

  17. ON SKEW-NORMAL MODEL FOR ECONOMICALLY ACTIVE POPULATION

    Directory of Open Access Journals (Sweden)

    OLOSUNDE AKINLOLU A

    2011-04-01

    Full Text Available The literature related to skew-symmetric distribution have grown rapidly in recent years but at the moment no publication on its applications concerning the description of economically active data with this type of probability models. In this paper, we provided an extension to this skew-normal distribution, which is also part of the family of skewed class of normal but with additional shape parameters δ. Some properties of this distribution are presented and finally, we considered fitting it to economically active population data. The model exhibited a better behaviour when compared to normal and skew normal distributions.

  18. Dynamic model of normal behavior of rock fractures

    Institute of Scientific and Technical Information of China (English)

    YANG Wen-yi; KONG Guang-ya; CAI Jun-gang

    2005-01-01

    Based on laboratory tests of artificial fractures in mortar material, established the dynamic constitutive model of normal behaviour of rock fracture,. The tests were systematically conducted under quasi-static and dynamic monotonic loading conditions. The fractures were of different numbers of asperities in contact and were subsequently of different initial contact areas, which imitated the natural rock fractures. The rate of compressive load applied normal to the fractures covers a wide range from 10-1 MPa/s (quasi-static) up to 103 MPa/s (highly dynamic). The normal stress-closure responses of fractures were measured for different loading rates. Based on the stress-closure relation curves measured, a nonlinear (hyperbolic) dynamic model of fracture, normal behaviour, termed as dynamic BB model, was proposed, which was modified from the existing BB model of static normal behaviour of fractures by taking into account the effect of loading rate.

  19. Mathematical modeling of normal pharyngeal bolus transport: a preliminary study.

    Science.gov (United States)

    Chang, M W; Rosendall, B; Finlayson, B A

    1998-07-01

    Dysphagia (difficulty in swallowing) is a common clinical symptom associated with many diseases, such as stroke, multiple sclerosis, neuromuscular diseases, and cancer. Its complications include choking, aspiration, malnutrition, cachexia, and dehydration. The goal in dysphagia management is to provide adequate nutrition and hydration while minimizing the risk of choking and aspiration. It is important to advance the individual toward oral feeding in a timely manner to enhance the recovery of swallowing function and preserve the quality of life. Current clinical assessments of dysphagia are limited in providing adequate guidelines for oral feeding. Mathematical modeling of the fluid dynamics of pharyngeal bolus transport provides a unique opportunity for studying the physiology and pathophysiology of swallowing. Finite element analysis (FEA) is a special case of computational fluid dynamics (CFD). In CFD, the flow of a fluid in a space is modeled by covering the space with a grid and predicting how the fluid moves from grid point to grid point. FEA is capable of solving problems with complex geometries and free surfaces. A preliminary pharyngeal model has been constructed using FEA. This model incorporates literature-reported, normal, anatomical data with time-dependent pharyngeal/upper esophageal sphincter (UES) wall motion obtained from videofluorography (VFG). This time-dependent wall motion can be implemented as a moving boundary condition in the model. Clinical kinematic data can be digitized from VFG studies to construct and test the mathematical model. The preliminary model demonstrates the feasibility of modeling pharyngeal bolus transport, which, to our knowledge, has not been attempted before. This model also addresses the need and the potential for CFD in understanding the physiology and pathophysiology of the pharyngeal phase of swallowing. Improvements of the model are underway. Combining the model with individualized clinical data should potentially

  20. Comparison of Joint Modeling Approaches Including Eulerian Sliding Interfaces

    Energy Technology Data Exchange (ETDEWEB)

    Lomov, I; Antoun, T; Vorobiev, O

    2009-12-16

    Accurate representation of discontinuities such as joints and faults is a key ingredient for high fidelity modeling of shock propagation in geologic media. The following study was done to improve treatment of discontinuities (joints) in the Eulerian hydrocode GEODYN (Lomov and Liu 2005). Lagrangian methods with conforming meshes and explicit inclusion of joints in the geologic model are well suited for such an analysis. Unfortunately, current meshing tools are unable to automatically generate adequate hexahedral meshes for large numbers of irregular polyhedra. Another concern is that joint stiffness in such explicit computations requires significantly reduced time steps, with negative implications for both the efficiency and quality of the numerical solution. An alternative approach is to use non-conforming meshes and embed joint information into regular computational elements. However, once slip displacement on the joints become comparable to the zone size, Lagrangian (even non-conforming) meshes could suffer from tangling and decreased time step problems. The use of non-conforming meshes in an Eulerian solver may alleviate these difficulties and provide a viable numerical approach for modeling the effects of faults on the dynamic response of geologic materials. We studied shock propagation in jointed/faulted media using a Lagrangian and two Eulerian approaches. To investigate the accuracy of this joint treatment the GEODYN calculations have been compared with results from the Lagrangian code GEODYN-L which uses an explicit treatment of joints via common plane contact. We explore two approaches to joint treatment in the code, one for joints with finite thickness and the other for tight joints. In all cases the sliding interfaces are tracked explicitly without homogenization or blending the joint and block response into an average response. In general, rock joints will introduce an increase in normal compliance in addition to a reduction in shear strength. In the

  1. A model of Barchan dunes including lateral shear stress.

    Science.gov (United States)

    Schwämmle, V; Herrmann, H J

    2005-01-01

    Barchan dunes are found where sand availability is low and wind direction quite constant. The two dimensional shear stress of the wind field and the sand movement by saltation and avalanches over a barchan dune are simulated. The model with one dimensional shear stress is extended including surface diffusion and lateral shear stress. The resulting final shape is compared to the results of the model with a one dimensional shear stress and confirmed by comparison to measurements. We found agreement and improvements with respect to the model with one dimensional shear stress. Additionally, a characteristic edge at the center of the windward side is discovered which is also observed for big barchans. Diffusion effects reduce this effect for small dunes.

  2. Proposal: A Hybrid Dictionary Modelling Approach for Malay Tweet Normalization

    Science.gov (United States)

    Muhamad, Nor Azlizawati Binti; Idris, Norisma; Arshi Saloot, Mohammad

    2017-02-01

    Malay Twitter message presents a special deviation from the original language. Malay Tweet widely used currently by Twitter users, especially at Malaya archipelago. Thus, it is important to make a normalization system which can translated Malay Tweet language into the standard Malay language. Some researchers have conducted in natural language processing which mainly focuses on normalizing English Twitter messages, while few studies have been done for normalize Malay Tweets. This paper proposes an approach to normalize Malay Twitter messages based on hybrid dictionary modelling methods. This approach normalizes noisy Malay twitter messages such as colloquially language, novel words, and interjections into standard Malay language. This research will be used Language Model and N-grams model.

  3. Human sperm chromatin stabilization: a proposed model including zinc bridges.

    Science.gov (United States)

    Björndahl, Lars; Kvist, Ulrik

    2010-01-01

    The primary focus of this review is to challenge the current concepts on sperm chromatin stability. The observations (i) that zinc depletion at ejaculation allows a rapid and total sperm chromatin decondensation without the addition of exogenous disulfide cleaving agents and (ii) that the human sperm chromatin contains one zinc for every protamine for every turn of the DNA helix suggest an alternative model for sperm chromatin structure may be plausible. An alternative model is therefore proposed, that the human spermatozoon could at ejaculation have a rapidly reversible zinc dependent chromatin stability: Zn(2+) stabilizes the structure and prevents the formation of excess disulfide bridges by a single mechanism, the formation of zinc bridges with protamine thiols of cysteine and potentially imidazole groups of histidine. Extraction of zinc enables two biologically totally different outcomes: immediate decondensation if chromatin fibers are concomitantly induced to repel (e.g. by phosphorylation in the ooplasm); otherwise freed thiols become committed into disulfide bridges creating a superstabilized chromatin. Spermatozoa in the zinc rich prostatic fluid (normally the first expelled ejaculate fraction) represent the physiological situation. Extraction of chromatin zinc can be accomplished by the seminal vesicular fluid. Collection of the ejaculate in one single container causes abnormal contact between spermatozoa and seminal vesicular fluid affecting the sperm chromatin stability. There are men in infertile couples with low content of sperm chromatin zinc due to loss of zinc during ejaculation and liquefaction. Tests for sperm DNA integrity may give false negative results due to decreased access for the assay to the DNA in superstabilized chromatin.

  4. The Semiparametric Normal Variance-Mean Mixture Model

    DEFF Research Database (Denmark)

    Korsholm, Lars

    1997-01-01

    We discuss the normal vairance-mean mixture model from a semi-parametric point of view, i.e. we let the mixing distribution belong to a non parametric family. The main results are consistency of the non parametric maximum likelihood estimat or in this case, and construction of an asymptotically...... normal and efficient estimator....

  5. Modified Normal Demand Distributions in (R,S)-Inventory Models

    NARCIS (Netherlands)

    Strijbosch, L.W.G.; Moors, J.J.A.

    2003-01-01

    To model demand, the normal distribution is by far the most popular; the disadvantage that it takes negative values is taken for granted.This paper proposes two modi.cations of the normal distribution, both taking non-negative values only.Safety factors and order-up-to-levels for the familiar (R,

  6. Goldilocks Models of Higher-Dimensional Inflation (including modulus stabilization)

    CERN Document Server

    Burgess, C P; Hayman, Peter; Patil, Subodh P

    2016-01-01

    We explore the mechanics of inflation in simplified extra-dimensional models involving an inflaton interacting with the Einstein-Maxwell system in two extra dimensions. The models are Goldilocks-like in that they are just complicated enough to include a mechanism to stabilize the extra-dimensional size, yet simple enough to solve the full 6D field equations using basic tools. The solutions are not limited to the effective 4D regime with H m_KK, but when they do standard 4D fluctuation calculations need not apply. When in a 4D regime the solutions predict eta ~ 0 hence n_s ~ 0.96 and r ~ 0.096 and so are ruled out if tensor modes remain unseen. Analysis of general parameters is difficult without a full 6D fluctuation calculation.

  7. Statistical validation of normal tissue complication probability models

    NARCIS (Netherlands)

    Xu, Cheng-Jian; van der Schaaf, Arjen; van t Veld, Aart; Langendijk, Johannes A.; Schilstra, Cornelis

    2012-01-01

    PURPOSE: To investigate the applicability and value of double cross-validation and permutation tests as established statistical approaches in the validation of normal tissue complication probability (NTCP) models. METHODS AND MATERIALS: A penalized regression method, LASSO (least absolute shrinkage

  8. Vector model for normal and dichromatic color vision.

    Science.gov (United States)

    Guth, S L; Massof, R W; Benzschawel, T

    1980-02-01

    The inclusion of cone mechanisms in a slightly revised version of an earlier model allows accounts of phenomena that involve receptor effects as well as dichromatic color vision. Intensity-dependent parameters that stimulate the adaptation of receptors and opponent and nonopponent mechanisms are varied to predict a wide range of data for both normals and dichromats, including: (i) color matching; (ii) the approximate apparent hue and saturation of the spectrum; (iii) foveal spectral sensitivities obtained by flicker photometry and by detection in the dark and under conditions of achromatic or chromatic adaptation; (iv) heterochromatic additivity failures in the dark-adapted and chromatically adapted eye; (v) approximate differences between brightness and luminance; and, (vi) color and wavelength discrimination under varying adaptation conditions.

  9. Progress Towards an LES Wall Model Including Unresolved Roughness

    Science.gov (United States)

    Craft, Kyle; Redman, Andrew; Aikens, Kurt

    2015-11-01

    Wall models used in large eddy simulations (LES) are often based on theories for hydraulically smooth walls. While this is reasonable for many applications, there are also many where the impact of surface roughness is important. A previously developed wall model has been used primarily for jet engine aeroacoustics. However, jet simulations have not accurately captured thick initial shear layers found in some experimental data. This may partly be due to nozzle wall roughness used in the experiments to promote turbulent boundary layers. As a result, the wall model is extended to include the effects of unresolved wall roughness through appropriate alterations to the log-law. The methodology is tested for incompressible flat plate boundary layers with different surface roughness. Correct trends are noted for the impact of surface roughness on the velocity profile. However, velocity deficit profiles and the Reynolds stresses do not collapse as well as expected. Possible reasons for the discrepancies as well as future work will be presented. This work used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by National Science Foundation grant number ACI-1053575. Computational resources on TACC Stampede were provided under XSEDE allocation ENG150001.

  10. Numerical Modeling of Electroacoustic Logging Including Joule Heating

    Science.gov (United States)

    Plyushchenkov, Boris D.; Nikitin, Anatoly A.; Turchaninov, Victor I.

    It is well known that electromagnetic field excites acoustic wave in a porous elastic medium saturated with fluid electrolyte due to electrokinetic conversion effect. Pride's equations describing this process are written in isothermal approximation. Update of these equations, which allows to take influence of Joule heating on acoustic waves propagation into account, is proposed here. This update includes terms describing the initiation of additional acoustic waves excited by thermoelastic stresses and the heat conduction equation with right side defined by Joule heating. Results of numerical modeling of several problems of propagation of acoustic waves excited by an electric field source with and without consideration of Joule heating effect in their statements are presented. From these results, it follows that influence of Joule heating should be taken into account at the numerical simulation of electroacoustic logging and at the interpretation of its log data.

  11. Modeling of the RF system for the normal conducting linac

    Institute of Scientific and Technical Information of China (English)

    GENG Zhe-Qiao; HOU Mi; PEI Guo-Xi

    2008-01-01

    To study the new RF control methods, a mathematic model of the RF system for the normal conducting linac is built and implemented with the software of Matlab. The model contains some typical units of the RF system, such as the klystron, the SLED and the traveling wave accelerating tube. Finally, the model is used to study the working point of the SLED and the adaptive feed forward algorithm for the RF control system. Simulation shows that the model works well as expected.

  12. Goldilocks models of higher-dimensional inflation (including modulus stabilization)

    Science.gov (United States)

    Burgess, C. P.; Enns, Jared J. H.; Hayman, Peter; Patil, Subodh P.

    2016-08-01

    We explore the mechanics of inflation within simplified extra-dimensional models involving an inflaton interacting with the Einstein-Maxwell system in two extra dimensions. The models are Goldilocks-like inasmuch as they are just complicated enough to include a mechanism to stabilize the extra-dimensional size (or modulus), yet simple enough to solve explicitly the full extra-dimensional field equations using only simple tools. The solutions are not restricted to the effective 4D regime with H ll mKK (the latter referring to the characteristic mass splitting of the Kaluza-Klein excitations) because the full extra-dimensional Einstein equations are solved. This allows an exploration of inflationary physics in a controlled calculational regime away from the usual four-dimensional lamp-post. The inclusion of modulus stabilization is important because experience with string models teaches that this is usually what makes models fail: stabilization energies easily dominate the shallow potentials required by slow roll and so open up directions to evolve that are steeper than those of the putative inflationary direction. We explore (numerically and analytically) three representative kinds of inflationary scenarios within this simple setup. In one the radion is trapped in an inflaton-dependent local minimum whose non-zero energy drives inflation. Inflation ends as this energy relaxes to zero when the inflaton finds its own minimum. The other two involve power-law scaling solutions during inflation. One of these is a dynamical attractor whose features are relatively insensitive to initial conditions but whose slow-roll parameters cannot be arbitrarily small; the other is not an attractor but can roll much more slowly, until eventually transitioning to the attractor. The scaling solutions can satisfy H > mKK, but when they do standard 4D fluctuation calculations need not apply. When in a 4D regime the solutions predict η simeq 0 and so r simeq 0.11 when ns simeq 0.96 and so

  13. Positive explorers: modeling dynamic control in normal aging.

    Science.gov (United States)

    Glass, Brian D; Osman, Magda

    2017-01-01

    Situations in which there are multiple changes occurring all at once and which demand complex decisions to be made are common throughout life, but little is known about how normal aging influences performance on these types of scenarios. To determine performance differences associated with normal aging, we test older and younger adults in a dynamic control task. The task involves the control of a single output variable over time via multiple and uncertain input controls. The Single Limited Input, Dynamic Exploratory Responses (SLIDER) computational model, is implemented to determine the behavioral characteristics associated with normal aging in a dynamic control task. Model-based analysis demonstrates a unique performance signature profile associated with normal aging. Specifically, older adults exhibit a positivity effect in which they are more influenced by positively valenced feedback, congruent with previous research, as well as enhanced exploratory behavior.

  14. Modelling psychiatric measures using Skew-Normal distributions

    Science.gov (United States)

    Counsell, N.; Cortina-Borja, M.; Lehtonen, A.; Stein, A.

    2011-01-01

    Data from psychiatric research frequently exhibit departures from Normality. Methods which utilise the data optimally to model the distribution directly are available. We highlight the issue of modelling skewness, resulting from screening instruments where the majority of respondents are healthy individuals and few participants have a value reflecting particular disorders. PMID:21036551

  15. STRONG NORMALIZATION IN TYPE SYSTEMS - A MODEL THEORETICAL APPROACH

    NARCIS (Netherlands)

    TERLOUW, J

    1995-01-01

    Tait's proof of strong normalization for the simply typed lambda-calculus is interpreted in a general model theoretical framework by means of the specification of a certain theory T and a certain model U of T. The argumentation is partly reduced to formal predicate logic by the application of

  16. Modeling pore corrosion in normally open gold- plated copper connectors.

    Energy Technology Data Exchange (ETDEWEB)

    Battaile, Corbett Chandler; Moffat, Harry K.; Sun, Amy Cha-Tien; Enos, David George; Serna, Lysle M.; Sorensen, Neil Robert

    2008-09-01

    The goal of this study is to model the electrical response of gold plated copper electrical contacts exposed to a mixed flowing gas stream consisting of air containing 10 ppb H{sub 2}S at 30 C and a relative humidity of 70%. This environment accelerates the attack normally observed in a light industrial environment (essentially a simplified version of the Battelle Class 2 environment). Corrosion rates were quantified by measuring the corrosion site density, size distribution, and the macroscopic electrical resistance of the aged surface as a function of exposure time. A pore corrosion numerical model was used to predict both the growth of copper sulfide corrosion product which blooms through defects in the gold layer and the resulting electrical contact resistance of the aged surface. Assumptions about the distribution of defects in the noble metal plating and the mechanism for how corrosion blooms affect electrical contact resistance were needed to complete the numerical model. Comparisons are made to the experimentally observed number density of corrosion sites, the size distribution of corrosion product blooms, and the cumulative probability distribution of the electrical contact resistance. Experimentally, the bloom site density increases as a function of time, whereas the bloom size distribution remains relatively independent of time. These two effects are included in the numerical model by adding a corrosion initiation probability proportional to the surface area along with a probability for bloom-growth extinction proportional to the corrosion product bloom volume. The cumulative probability distribution of electrical resistance becomes skewed as exposure time increases. While the electrical contact resistance increases as a function of time for a fraction of the bloom population, the median value remains relatively unchanged. In order to model this behavior, the resistance calculated for large blooms has been weighted more heavily.

  17. [A challenge to primary open-angle glaucoma including normal-pressure. Clinical problems and their scientific solution].

    Science.gov (United States)

    Sugiyama, Kazuhisa

    2012-03-01

    Primary open-angle glaucoma (POAG), including normal-tension glaucoma (NTG), is reported by the Tajimi Study to afflict 3.9% of the total population, and this represents about 80% of all total glaucoma cases which, in total, afflict 5.0% of the population. We tried to analyze the clinical problems relating to POAG by looking at the pathogenesis, intraocular pressure (IOP), therapy, neuroprotection and surgery of the disease. To elucidate the pathogenesis of glaucoma progression, we measured retinal nerve fiber layer defect (RNFLD) angles', and divided the NTG cases into 2 groups, enlarged RNFLD and stable RNFLD. Disc hemorrhages were found to be significantly more frequent in the enlarged group than in the stable group. RNFLD was enlarged in the direction of disc hemorrhage in over 80% of the eyes. In the majority of the eyes of the enlarged group, the enlargement of RNFLD was toward the fovea. The enlargement of RNFLD in NTG was closely associated with disc hemorrhage and the deterioration of the visual field. We developed a simultaneous structure and function evaluation technique combining spectral-domain (SD) optical coherence tomography (OCT) and fundus-oriented perimeters for the detection of visual field abnormalities in the RNFLD area. We superimposed the ganglion cell complex map obtained by SD-OCT on the fundus-oriented perimeter image. We observed very early or preperimetric normal pressure glaucoma as well as disc hemorrhage adjacent to the borders of the RNFLD. The borderline of the RNFLD seemed to be the thinnest RNFL and had the lowest retinal sensitivity (Active site for RNFLD progression). To clarify the role of the circadian clock genes in the generation of a 24-hour IOP rhythm, we used the microneedle method to measure the IOP at eight time points daily, both in wild type mice and Cry-deficient (Cry 1-/-Cry 2-/-) mice. In the wild-type mice living in light-dark conditions, the pressure measured in the light phase was significantly lower than in

  18. Study on the Universality of the Normal Cloud Model

    Institute of Scientific and Technical Information of China (English)

    LiDeyi; LiuChangyu; LiuLuying

    2005-01-01

    The distribution function is an important tool in the study of the stochastic variances. The normal distribution is very popular in the nature and our society. The idea of membership functions is the foundation of the fuzzy sets theory. While the fuzzy theory is widely used, the completely certain membership function that has no any fuzziness at all has been the bottleneck of the applications of this theory.Cloud models are the effective tools in transforming between qualitative concepts and their quantitative expressions. It can represent the fuzziness and randomness and their relations of uncertain concepts. Also cloud models can show the concept granularity in multi-scale spaces by the digital characteristic Entropy (En). The normal cloud model not only broadens the form conditions of the normal distribution but also makes the normal membership function be the expectation of the random membership degree. In this paper, the universality of the normal cloud model is proved, which is more superior and easier, and can fit the fuzziness and gentleness of human cognitive processing.It would be more applicable and universal in the representation of uncertain notions.

  19. Including spatial data in nutrient balance modelling on dairy farms

    Science.gov (United States)

    van Leeuwen, Maricke; van Middelaar, Corina; Stoof, Cathelijne; Oenema, Jouke; Stoorvogel, Jetse; de Boer, Imke

    2017-04-01

    The Annual Nutrient Cycle Assessment (ANCA) calculates the nitrogen (N) and phosphorus (P) balance at a dairy farm, while taking into account the subsequent nutrient cycles of the herd, manure, soil and crop components. Since January 2016, Dutch dairy farmers are required to use ANCA in order to increase understanding of nutrient flows and to minimize nutrient losses to the environment. A nutrient balance calculates the difference between nutrient inputs and outputs. Nutrients enter the farm via purchased feed, fertilizers, deposition and fixation by legumes (nitrogen), and leave the farm via milk, livestock, manure, and roughages. A positive balance indicates to which extent N and/or P are lost to the environment via gaseous emissions (N), leaching, run-off and accumulation in soil. A negative balance indicates that N and/or P are depleted from soil. ANCA was designed to calculate average nutrient flows on farm level (for the herd, manure, soil and crop components). ANCA was not designed to perform calculations of nutrient flows at the field level, as it uses averaged nutrient inputs and outputs across all fields, and it does not include field specific soil characteristics. Land management decisions, however, such as the level of N and P application, are typically taken at the field level given the specific crop and soil characteristics. Therefore the information that ANCA provides is likely not sufficient to support farmers' decisions on land management to minimize nutrient losses to the environment. This is particularly a problem when land management and soils vary between fields. For an accurate estimate of nutrient flows in a given farming system that can be used to optimize land management, the spatial scale of nutrient inputs and outputs (and thus the effect of land management and soil variation) could be essential. Our aim was to determine the effect of the spatial scale of nutrient inputs and outputs on modelled nutrient flows and nutrient use efficiencies

  20. A Discrete Velocity Traffic Kinetic Model Including Desired Speed

    Directory of Open Access Journals (Sweden)

    Shoufeng Lu

    2013-05-01

    Full Text Available We introduce the desired speed variable into the table of games and formulate a new table of games and the corresponding discrete traffic kinetic model. We use the hybrid programming technique of VB and MATLAB to develop the program. Lastly, we compared the proposed model result and the detector data. The results show that the proposed model can describe the traffic flow evolution.

  1. Semi-holographic model including the radiation component

    CERN Document Server

    del Campo, Sergio; Magaña, Juan; Villanueva, J R

    2014-01-01

    In this letter we study the semi holographic model which corresponds to the radiative version of the model proposed by Zhang et al. (Phys. Lett. B 694 (2010), 177) and revisited by C\\'ardenas et al. (Mon. Not. Roy. Astron. Soc. 438 (2014), 3603). This inclusion makes the model more realistic, so allows us to test it with current observational data and then answer if the inconsistency reported by C\\'ardenas et al. is relaxed.

  2. A Fault Evolution Model Including the Rupture Dynamic Simulation

    Science.gov (United States)

    Wu, Y.; Chen, X.

    2011-12-01

    We perform a preliminary numerical simulation of seismicity and stress evolution along a strike-slip fault in a 3D elastic half space. Following work of Ben-Zion (1996), the fault geometry is devised as a vertical plane which is about 70 km long and 17 km wide, comparable to the size of San Andreas Fault around Parkfield. The loading mechanism is described by "backslip" method. The fault failure is governed by a static/kinetic friction law, and induced stress transfer is calculated with Okada's static solution. In order to track the rupture propagation in detail, we allow induced stress to propagate through the medium at the shear wave velocity by introducing a distance-dependent time delay to responses to stress changes. Current simulation indicates small to moderate earthquakes following the Gutenberg-Richter law and quasi-periodical characteristic large earthquakes, which are consistent with previous work by others. Next we will consider introducing a more realistic friction law, namely, the laboratory-derived rate- and state- dependent law, which can simulate more realistic and complicated sliding behavior such as the stable and unstable slip, the aseismic sliding and the slip nucleation process. In addition, the long duration of aftershocks is expected to be reproduced due to this time-dependent friction law, which is not available in current seismicity simulation. The other difference from previous work is that we are trying to include the dynamic ruptures in this study. Most previous study on seismicity simulation is based on the static solution when dealing with failure induced stress changes. However, studies of numerical simulation of rupture dynamics have revealed lots of important details which are missing in the quasi-static/quasi- dynamic simulation. For example, dynamic simulations indicate that the slip on the ground surface becomes larger if the dynamic rupture process reaches the free surface. The concentration of stress on the propagating crack

  3. Evacuation modeling including traveler information and compliance behavior

    NARCIS (Netherlands)

    Pel, A.J.; Hoogendoorn, S.P.; Bliemer, M.C.J.

    2010-01-01

    Traffic simulation models are often used to support decisions when planning an evacuation. Scenario analyses based on these models then typically focus on traffic dynamics and the effect of traffic control measures in order to locate possible bottlenecks and predict evacuation times. A clear approac

  4. Global atmospheric model for mercury including oxidation by bromine atoms

    Directory of Open Access Journals (Sweden)

    C. D. Holmes

    2010-12-01

    Full Text Available Global models of atmospheric mercury generally assume that gas-phase OH and ozone are the main oxidants converting Hg0 to HgII and thus driving mercury deposition to ecosystems. However, thermodynamic considerations argue against the importance of these reactions. We demonstrate here the viability of atomic bromine (Br as an alternative Hg0 oxidant. We conduct a global 3-D simulation with the GEOS-Chem model assuming gas-phase Br to be the sole Hg0 oxidant (Hg + Br model and compare to the previous version of the model with OH and ozone as the sole oxidants (Hg + OH/O3 model. We specify global 3-D Br concentration fields based on our best understanding of tropospheric and stratospheric Br chemistry. In both the Hg + Br and Hg + OH/O3 models, we add an aqueous photochemical reduction of HgII in cloud to impose a tropospheric lifetime for mercury of 6.5 months against deposition, as needed to reconcile observed total gaseous mercury (TGM concentrations with current estimates of anthropogenic emissions. This added reduction would not be necessary in the Hg + Br model if we adjusted the Br oxidation kinetics downward within their range of uncertainty. We find that the Hg + Br and Hg + OH/O3 models are equally capable of reproducing the spatial distribution of TGM and its seasonal cycle at northern mid-latitudes. The Hg + Br model shows a steeper decline of TGM concentrations from the tropics to southern mid-latitudes. Only the Hg + Br model can reproduce the springtime depletion and summer rebound of TGM observed at polar sites; the snowpack component of GEOS-Chem suggests that 40% of HgII deposited to snow in the Arctic is transferred to the ocean and land reservoirs, amounting to a net deposition flux to the Arctic of 60 Mg a−1. Summertime events of depleted Hg0 at Antarctic sites due to subsidence are much better simulated by

  5. Pilot Wave model that includes creation and annihilation of particles

    CERN Document Server

    Sverdlov, Roman

    2010-01-01

    The purpose of this paper is to come up with a Pilot Wave model of quantum field theory that incorporates particle creation and annihilation without sacrificing determinism. This has been previously attempted in an article by the same author titled "Incorporating particle creation and annihilation in Pilot Wave model", in a much less satisfactory way. In this paper I would like to "clean up" some of the things. In particular, I would like to get rid of a very unnatural concept of "visibility" of particles, which makes the model much simpler. On the other hand, I would like to add a mechanism for decoherence, which was absent in the previous version.

  6. Global atmospheric model for mercury including oxidation by bromine atoms

    Directory of Open Access Journals (Sweden)

    C. D. Holmes

    2010-08-01

    Full Text Available Global models of atmospheric mercury generally assume that OH and ozone are the main oxidants converting Hg0 to HgII and thus driving mercury deposition to ecosystems. However, thermodynamic considerations argue against the importance of these reactions. We demonstrate here the viability of atomic bromine (Br as an alternative Hg0 oxidant. We conduct a global 3-D simulation with the GEOS-Chem model assuming Br to be the sole Hg0 oxidant (Hg + Br model and compare to the previous version of the model with OH and ozone as the sole oxidants (Hg + OH/O3 model. We specify global 3-D Br concentration fields based on our best understanding of tropospheric and stratospheric Br chemistry. In both the Hg + Br and Hg + OH/O3 models, we add an aqueous photochemical reduction of HgII in cloud to impose a tropospheric lifetime for mercury of 6.5 months against deposition, as needed to reconcile observed total gaseous mercury (TGM concentrations with current estimates of anthropogenic emissions. This added reduction would not be necessary in the Hg + Br model if we adjusted the Br oxidation kinetics downward within their range of uncertainty. We find that the Hg + Br and Hg + OH/O3 models are equally capable of reproducing the spatial distribution of TGM and its seasonal cycle at northern mid-latitudes. The Hg + Br model shows a steeper decline of TGM concentrations from the tropics to southern mid-latitudes. Only the Hg + Br model can reproduce the springtime depletion and summer rebound of TGM observed at polar sites; the snowpack component of GEOS-Chem suggests that 40% of HgII deposited to snow in the Arctic is transferred to the ocean and land reservoirs, amounting to a net deposition flux of 60 Mg a−1. Summertime events of depleted Hg0 at Antarctic sites due to subsidence are much better simulated by the Hg + Br model. Model

  7. An Intracellular Calcium Oscillations Model Including Mitochondrial Calcium Cycling

    Institute of Scientific and Technical Information of China (English)

    SHI Xiao-Min; LIU Zeng-Rong

    2005-01-01

    @@ Calcium is a ubiquitous second messenger. Mitochondria contributes significantly to intracellular Ca2+ dynamics.The experiment of Kaftan et al. [J. Biol. Chem. 275(2000) 25465] demonstrated that inhibiting mitochondrial Ca2+ uptake can reduce the frequency of cytosolic Ca2+ concentration oscillations of gonadotropes. By considering the mitochondrial Ca2+ cycling we develop a three-variable model of intracellular Ca2+ oscillations based on the models of Atri et al. [Biophys. J. 65 (1993) 1727] and Falcke et al. [Biophys. J. 77 (1999) 37]. The model reproduces the fact that mitochondrial Ca2+ cycling increases the frequency of cytosolic Ca2+ oscillations, which accords with Kaftan's results. Moreover the model predicts that when the mitochondria overload with Ca2+, the cytosolic Ca2+ oscillations vanish, which may trigger apoptosis.

  8. Bayesian Option Pricing Using Mixed Normal Heteroskedasticity Models

    DEFF Research Database (Denmark)

    Rombouts, Jeroen V.K.; Stentoft, Lars Peter

    While stochastic volatility models improve on the option pricing error when compared to the Black-Scholes-Merton model, mispricings remain. This paper uses mixed normal heteroskedasticity models to price options. Our model allows for significant negative skewness and time varying higher order...... moments of the risk neutral distribution. Parameter inference using Gibbs sampling is explained and we detail how to compute risk neutral predictive densities taking into account parameter uncertainty. When forecasting out-of-sample options on the S&P 500 index, substantial improvements are found compared...

  9. Bayesian model selection for constrained multivariate normal linear models

    NARCIS (Netherlands)

    Mulder, J.

    2010-01-01

    The expectations that researchers have about the structure in the data can often be formulated in terms of equality constraints and/or inequality constraints on the parameters in the model that is used. In a (M)AN(C)OVA model, researchers have expectations about the differences between the

  10. Cement-aggregate compatibility and structure property relationships including modelling

    Energy Technology Data Exchange (ETDEWEB)

    Jennings, H.M.; Xi, Y.

    1993-07-15

    The role of aggregate, and its interface with cement paste, is discussed with a view toward establishing models that relate structure to properties. Both short (nm) and long (mm) range structure must be considered. The short range structure of the interface depends not only on the physical distribution of the various phases, but also on moisture content and reactivity of aggregate. Changes that occur on drying, i.e. shrinkage, may alter the structure which, in turn, feeds back to alter further drying and shrinkage. The interaction is dynamic, even without further hydration of cement paste, and the dynamic characteristic must be considered in order to fully understand and model its contribution to properties. Microstructure and properties are two subjects which have been pursued somewhat separately. This review discusses both disciplines with a view toward finding common research goals in the future. Finally, comment is made on possible chemical reactions which may occur between aggregate and cement paste.

  11. Including lateral interactions into microkinetic models of catalytic reactions

    DEFF Research Database (Denmark)

    Hellman, Anders; Honkala, Johanna Karoliina

    2007-01-01

    In many catalytic reactions lateral interactions between adsorbates are believed to have a strong influence on the reaction rates. We apply a microkinetic model to explore the effect of lateral interactions and how to efficiently take them into account in a simple catalytic reaction. Three differ...... different approximations are investigated: site, mean-field, and quasichemical approximations. The obtained results are compared to accurate Monte Carlo numbers. In the end, we apply the approximations to a real catalytic reaction, namely, ammonia synthesis....

  12. Variational Bayes for Regime-Switching Log-Normal Models

    Directory of Open Access Journals (Sweden)

    Hui Zhao

    2014-07-01

    Full Text Available The power of projection using divergence functions is a major theme in information geometry. One version of this is the variational Bayes (VB method. This paper looks at VB in the context of other projection-based methods in information geometry. It also describes how to apply VB to the regime-switching log-normal model and how it provides a computationally fast solution to quantify the uncertainty in the model specification. The results show that the method can recover exactly the model structure, gives the reasonable point estimates and is very computationally efficient. The potential problems of the method in quantifying the parameter uncertainty are discussed.

  13. Neighboring extremal optimal control design including model mismatch errors

    Energy Technology Data Exchange (ETDEWEB)

    Kim, T.J. [Sandia National Labs., Albuquerque, NM (United States); Hull, D.G. [Texas Univ., Austin, TX (United States). Dept. of Aerospace Engineering and Engineering Mechanics

    1994-11-01

    The mismatch control technique that is used to simplify model equations of motion in order to determine analytic optimal control laws is extended using neighboring extremal theory. The first variation optimal control equations are linearized about the extremal path to account for perturbations in the initial state and the final constraint manifold. A numerical example demonstrates that the tuning procedure inherent in the mismatch control method increases the performance of the controls to the level of a numerically-determined piecewise-linear controller.

  14. Double pendulum model for tennis stroke including a collision process

    CERN Document Server

    Youn, Sun-Hyun

    2015-01-01

    By means of adding a collision process between the ball and racket in double pendulum model, we analyzed the tennis stroke. It is possible that the speed of the rebound ball does not simply depend on the angular velocity of the racket, and higher angular velocity sometimes gives lower ball speed. We numerically showed that the proper time lagged racket rotation increases the speed of the rebound ball by 20%. We also showed that the elbow should move in order to add the angular velocity of the racket.

  15. Statistical validation of normal tissue complication probability models.

    Science.gov (United States)

    Xu, Cheng-Jian; van der Schaaf, Arjen; Van't Veld, Aart A; Langendijk, Johannes A; Schilstra, Cornelis

    2012-09-01

    To investigate the applicability and value of double cross-validation and permutation tests as established statistical approaches in the validation of normal tissue complication probability (NTCP) models. A penalized regression method, LASSO (least absolute shrinkage and selection operator), was used to build NTCP models for xerostomia after radiation therapy treatment of head-and-neck cancer. Model assessment was based on the likelihood function and the area under the receiver operating characteristic curve. Repeated double cross-validation showed the uncertainty and instability of the NTCP models and indicated that the statistical significance of model performance can be obtained by permutation testing. Repeated double cross-validation and permutation tests are recommended to validate NTCP models before clinical use. Copyright © 2012 Elsevier Inc. All rights reserved.

  16. Statistical Validation of Normal Tissue Complication Probability Models

    Energy Technology Data Exchange (ETDEWEB)

    Xu Chengjian, E-mail: c.j.xu@umcg.nl [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Schaaf, Arjen van der; Veld, Aart A. van' t; Langendijk, Johannes A. [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Schilstra, Cornelis [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Radiotherapy Institute Friesland, Leeuwarden (Netherlands)

    2012-09-01

    Purpose: To investigate the applicability and value of double cross-validation and permutation tests as established statistical approaches in the validation of normal tissue complication probability (NTCP) models. Methods and Materials: A penalized regression method, LASSO (least absolute shrinkage and selection operator), was used to build NTCP models for xerostomia after radiation therapy treatment of head-and-neck cancer. Model assessment was based on the likelihood function and the area under the receiver operating characteristic curve. Results: Repeated double cross-validation showed the uncertainty and instability of the NTCP models and indicated that the statistical significance of model performance can be obtained by permutation testing. Conclusion: Repeated double cross-validation and permutation tests are recommended to validate NTCP models before clinical use.

  17. Modelling of Dual-Junction Solar Cells including Tunnel Junction

    Directory of Open Access Journals (Sweden)

    Abdelaziz Amine

    2013-01-01

    Full Text Available Monolithically stacked multijunction solar cells based on III–V semiconductors materials are the state-of-art of approach for high efficiency photovoltaic energy conversion, in particular for space applications. The individual subcells of the multi-junction structure are interconnected via tunnel diodes which must be optically transparent and connect the component cells with a minimum electrical resistance. The quality of these diodes determines the output performance of the solar cell. The purpose of this work is to contribute to the investigation of the tunnel electrical resistance of such a multi-junction cell through the analysis of the current-voltage (J-V characteristics under illumination. Our approach is based on an equivalent circuit model of a diode for each subcell. We examine the effect of tunnel resistance on the performance of a multi-junction cell using minimization of the least squares technique.

  18. Global model including multistep ionizations in helium plasmas

    Science.gov (United States)

    Oh, Seung-Ju; Lee, Hyo-Chang; Chung, Chin-Wook

    2016-12-01

    Particle and power balance equations including stepwise ionizations are derived and solved in helium plasmas. In the balance equations, two metastable states (21S1 in singlet and 23S1 triplet) are considered and the followings are obtained. The plasma density linearly increases and the electron temperature is relatively in a constant value against the absorbed power. It is also found that the contribution to multi-step ionization with respect to the single-step ionization is in the range of 8%-23%, as the gas pressure increases from 10 mTorr to 100 mTorr. Compared to the results in the argon plasma, there is little variation in the collisional energy loss per electron-ion pair created (ɛc) with absorbed power and gas pressure due to the small collision cross section and higher inelastic collision threshold energy.

  19. Modelization of a water tank including a PCM module

    Energy Technology Data Exchange (ETDEWEB)

    Ibanez, Manuel [Dept. de Medi Ambient i Ciencies del Sol, Universitat de Lleida, Rovira Roure 191, 25198 Lleida (Spain); Cabeza, Luisa F.; Sole, Cristian; Roca, Joan; Nogues, Miquel [Dept. d' Informatica i Eng. Industrial, Universitat de Lleida, Jaume II 69, 25001 Lleida (Spain)

    2006-08-15

    The reduction of CO{sub 2} emissions is a key component for today's governments. Therefore, implementation of more and more systems with renewable energies is necessary. Solar systems for single family houses or residential buildings need a big water tank that many times is not easy to locate. This paper studies the modelization of a new technology where PCM modules are implemented in domestic hot water tanks to reduce their size without reducing the energy stored. A new TRNSYS component, based in the already existing TYPE 60, was developed, called TYPE 60PCM. After tuning the new component with experimental results, two more experiences were developed to validate the simulation of a water tank with two cylindrical PCM modules using type 60PCM, the cooldown and reheating experiments. Concordance between experimental and simulated data was very good. Since the new TRNSYS component was developed to simulate full solar systems, comparison of experimental results from a pilot plant solar system with simulations were performed, and they confirmed that the type 60PCM is a powerful tool to evaluate the performance of PCM modules in water tanks. (author)

  20. EQUIVALENT NORMAL CURVATURE APPROACH MILLING MODEL OF MACHINING FREEFORM SURFACES

    Institute of Scientific and Technical Information of China (English)

    YI Xianzhong; MA Weiguo; QI Haiying; YAN Zesheng; GAO Deli

    2008-01-01

    A new milling methodology with the equivalent normal curvature milling model machining freeform surfaces is proposed based on the normal curvature theorems on differential geometry. Moreover, a specialized whirlwind milling tool and a 5-axis CNC horizontal milling machine are introduced. This new milling model can efficiently enlarge the material removal volume at the tip of the whirlwind milling tool and improve the producing capacity. The machining strategy of this model is to regulate the orientation of the whirlwind milling tool relatively to the principal directions of the workpiece surface at the point of contact, so as to create a full match with collision avoidance between the workpiece surface and the symmetric rotational surface of the milling tool. The practical results show that this new milling model is an effective method in machining complex three- dimensional surfaces. This model has a good improvement on finishing machining time and scallop height in machining the freeform surfaces over other milling processes. Some actual examples for manufacturing the freeform surfaces with this new model are given.

  1. A NEW TEST FOR NORMALITY IN LINEAR AUTOREGRESSIVE MODELS

    Institute of Scientific and Technical Information of China (English)

    CHEN Min; WU Guofu; Gemai Chen

    2002-01-01

    A nonparametric test for normality of linear autoregressive time series isproposed in this paper. The test is based on the best one-step forecast in mean squarewith time reverse. Some asymptotic theory is developed for the test, and it is shown thatthe test is easy to use and has good powers. The empirical percentage points to conductthe test in practice are provided and three examples using real data are included.

  2. A Modelling of Normal and Abnormal EMG Silent Period Generation of Masseter Muscle

    Energy Technology Data Exchange (ETDEWEB)

    Kim, T.H.; Jeon, C.I. [University Of Seoul, Seoul (Korea); Lee, S.H. [Induk Institute of Technology, Seoul (Korea)

    2003-02-01

    This paper proposes a model of SP(silent period) generation in masseter muscle by means of computer simulation. The model is based on the anatomical and physiological properties of trigeminal nervous system. In determining the SP generation pathway, evoked SPs of masseter muscle after mechanical stimulation to the chin are divided into normal and abnormal group. Normal SP is produced by the activation of mechanoreceptors in periodontal ligament. The activation of nociceptors contributes to the latter part of normal SP, abnormal extended SP is produced. As a result, the EMG signal generated by a proposed SP generation model is similar to both real EMG signal including normal SP and abnormal extended SP with TMJ patients. The result of this study have shown differences of SP generation mechanism between subjects both with and without TMJ dysfunction. (author). 21 refs., 12 figs., 1 tab.

  3. Steady-state analysis of activated sludge processes with a settler model including sludge compression.

    Science.gov (United States)

    Diehl, S; Zambrano, J; Carlsson, B

    2016-01-01

    A reduced model of a completely stirred-tank bioreactor coupled to a settling tank with recycle is analyzed in its steady states. In the reactor, the concentrations of one dominant particulate biomass and one soluble substrate component are modelled. While the biomass decay rate is assumed to be constant, growth kinetics can depend on both substrate and biomass concentrations, and optionally model substrate inhibition. Compressive and hindered settling phenomena are included using the Bürger-Diehl settler model, which consists of a partial differential equation. Steady-state solutions of this partial differential equation are obtained from an ordinary differential equation, making steady-state analysis of the entire plant difficult. A key result showing that the ordinary differential equation can be replaced with an approximate algebraic equation simplifies model analysis. This algebraic equation takes the location of the sludge-blanket during normal operation into account, allowing for the limiting flux capacity caused by compressive settling to easily be included in the steady-state mass balance equations for the entire plant system. This novel approach grants the possibility of more realistic solutions than other previously published reduced models, comprised of yet simpler settler assumptions. The steady-state concentrations, solids residence time, and the wastage flow ratio are functions of the recycle ratio. Solutions are shown for various growth kinetics; with different values of biomass decay rate, influent volumetric flow, and substrate concentration.

  4. Normalization and Implementation of Three Gravitational Acceleration Models

    Science.gov (United States)

    Eckman, Randy A.; Brown, Aaron J.; Adamo, Daniel R.; Gottlieb, Robert G.

    2016-01-01

    Unlike the uniform density spherical shell approximations of Newton, the consequence of spaceflight in the real universe is that gravitational fields are sensitive to the asphericity of their generating central bodies. The gravitational potential of an aspherical central body is typically resolved using spherical harmonic approximations. However, attempting to directly calculate the spherical harmonic approximations results in at least two singularities that must be removed to generalize the method and solve for any possible orbit, including polar orbits. Samuel Pines, Bill Lear, and Robert Gottlieb developed three unique algorithms to eliminate these singularities. This paper documents the methodical normalization of two of the three known formulations for singularity-free gravitational acceleration (namely, the Lear and Gottlieb algorithms) and formulates a general method for defining normalization parameters used to generate normalized Legendre polynomials and Associated Legendre Functions (ALFs) for any algorithm. A treatment of the conventional formulation of the gravitational potential and acceleration is also provided, in addition to a brief overview of the philosophical differences between the three known singularity-free algorithms.

  5. Innovative Liner Concepts: Experiments and Impedance Modeling of Liners Including the Effect of Bias Flow

    Science.gov (United States)

    Kelly, Jeff; Betts, Juan Fernando; Fuller, Chris

    2000-01-01

    The study of normal impedance of perforated plate acoustic liners including the effect of bias flow was studied. Two impedance models were developed by modeling the internal flows of perforate orifices as infinite tubes with the inclusion of end corrections to handle finite length effects. These models assumed incompressible and compressible flows, respectively, between the far field and the perforate orifice. The incompressible model was used to predict impedance results for perforated plates with percent open areas ranging from 5% to 15%. The predicted resistance results showed better agreement with experiments for the higher percent open area samples. The agreement also tended to deteriorate as bias flow was increased. For perforated plates with percent open areas ranging from 1% to 5%, the compressible model was used to predict impedance results. The model predictions were closer to the experimental resistance results for the 2% to 3% open area samples. The predictions tended to deteriorate as bias flow was increased. The reactance results were well predicted by the models for the higher percent open area, but deteriorated as the percent open area was lowered (5%) and bias flow was increased. A fit was done on the incompressible model to the experimental database. The fit was performed using an optimization routine that found the optimal set of multiplication coefficients to the non-dimensional groups that minimized the least squares slope error between predictions and experiments. The result of the fit indicated that terms not associated with bias flow required a greater degree of correction than the terms associated with the bias flow. This model improved agreement with experiments by nearly 15% for the low percent open area (5%) samples when compared to the unfitted model. The fitted model and the unfitted model performed equally well for the higher percent open area (10% and 15%).

  6. Testing and modeling non-normality within the one-factor model

    NARCIS (Netherlands)

    Molenaar, D.; Dolan, C.V.; Verhelst, N.D.

    2010-01-01

    Maximum likelihood estimation in the one-factor model is based on the assumption of multivariate normality for the observed data. This general distributional assumption implies three specific assumptions for the parameters in the one-factor model: the common factor has a normal distribution; the res

  7. Testing and modeling non-normality within the one-factor model

    NARCIS (Netherlands)

    Molenaar, D.; Dolan, C.V.; Verhelst, N.D.

    2010-01-01

    Maximum likelihood estimation in the one-factor model is based on the assumption of multivariate normality for the observed data. This general distributional assumption implies three specific assumptions for the parameters in the one-factor model: the common factor has a normal distribution; the

  8. Pharmacokinetic modeling of ascorbate diffusion through normal and tumor tissue.

    Science.gov (United States)

    Kuiper, Caroline; Vissers, Margreet C M; Hicks, Kevin O

    2014-12-01

    Ascorbate is delivered to cells via the vasculature, but its ability to penetrate into tissues remote from blood vessels is unknown. This is particularly relevant to solid tumors, which often contain regions with dysfunctional vasculature, with impaired oxygen and nutrient delivery, resulting in upregulation of the hypoxic response and also the likely depletion of essential plasma-derived biomolecules, such as ascorbate. In this study, we have utilized a well-established multicell-layered, three-dimensional pharmacokinetic model to measure ascorbate diffusion and transport parameters through dense tissue in vitro. Ascorbate was found to penetrate the tissue at a slightly lower rate than mannitol and to travel via the paracellular route. Uptake parameters into the cells were also determined. These data were fitted to the diffusion model, and simulations of ascorbate pharmacokinetics in normal tissue and in hypoxic tumor tissue were performed with varying input concentrations, ranging from normal dietary plasma levels (10-100 μM) to pharmacological levels (>1 mM) as seen with intravenous infusion. The data and simulations demonstrate heterogeneous distribution of ascorbate in tumor tissue at physiological blood levels and provide insight into the range of plasma ascorbate concentrations and exposure times needed to saturate all regions of a tumor. The predictions suggest that supraphysiological plasma ascorbate concentrations (>100 μM) are required to achieve effective delivery of ascorbate to poorly vascularized tumor tissue.

  9. Modelling of tension stiffening for normal and high strength concrete

    DEFF Research Database (Denmark)

    Christiansen, Morten Bo; Nielsen, Mogens Peter

    1998-01-01

    Accurate calculations of the stiffness of concrete members are rare. Only in the uncracked state and the fully cracked state, where the reinforcement is near yielding, the stiffness calculations are relatively easy. The difficulties are due to the fact that concrete between cracks may give...... a substantial contribution to the stiffness, a phenomenon which is generally referred to as tension stiffening. The present paper describes a new theory of tension stiffening. It is based on a simple physical model for pure tension, which works with three different stages of crack generation. In a simplified...... form the model is extended to apply to biaxial stress fields as well. To determine the biaxial stress field, the theorem of minimum complementary elastic energy is used. The theory has been compared with tests on rods, disks, and beams of both normal and high strength concrete, and very good results...

  10. Normality of raw data in general linear models: The most widespread myth in statistics

    Science.gov (United States)

    Kery, Marc; Hatfield, Jeff S.

    2003-01-01

    In years of statistical consulting for ecologists and wildlife biologists, by far the most common misconception we have come across has been the one about normality in general linear models. These comprise a very large part of the statistical models used in ecology and include t tests, simple and multiple linear regression, polynomial regression, and analysis of variance (ANOVA) and covariance (ANCOVA). There is a widely held belief that the normality assumption pertains to the raw data rather than to the model residuals. We suspect that this error may also occur in countless published studies, whenever the normality assumption is tested prior to analysis. This may lead to the use of nonparametric alternatives (if there are any), when parametric tests would indeed be appropriate, or to use of transformations of raw data, which may introduce hidden assumptions such as multiplicative effects on the natural scale in the case of log-transformed data. Our aim here is to dispel this myth. We very briefly describe relevant theory for two cases of general linear models to show that the residuals need to be normally distributed if tests requiring normality are to be used, such as t and F tests. We then give two examples demonstrating that the distribution of the response variable may be nonnormal, and yet the residuals are well behaved. We do not go into the issue of how to test normality; instead we display the distributions of response variables and residuals graphically.

  11. Modeling speech intelligibility in quiet and noise in listeners with normal and impaired hearing.

    Science.gov (United States)

    Rhebergen, Koenraad S; Lyzenga, Johannes; Dreschler, Wouter A; Festen, Joost M

    2010-03-01

    The speech intelligibility index (SII) is an often used calculation method for estimating the proportion of audible speech in noise. For speech reception thresholds (SRTs), measured in normally hearing listeners using various types of stationary noise, this model predicts a fairly constant speech proportion of about 0.33, necessary for Dutch sentence intelligibility. However, when the SII model is applied for SRTs in quiet, the estimated speech proportions are often higher, and show a larger inter-subject variability, than found for speech in noise near normal speech levels [65 dB sound pressure level (SPL)]. The present model attempts to alleviate this problem by including cochlear compression. It is based on a loudness model for normally hearing and hearing-impaired listeners of Moore and Glasberg [(2004). Hear. Res. 188, 70-88]. It estimates internal excitation levels for speech and noise and then calculates the proportion of speech above noise and threshold using similar spectral weighting as used in the SII. The present model and the standard SII were used to predict SII values in quiet and in stationary noise for normally hearing and hearing-impaired listeners. The present model predicted SIIs for three listener types (normal hearing, noise-induced, and age-induced hearing loss) with markedly less variability than the standard SII.

  12. The normal zone propagation in ATLAS B00 model coil

    CERN Document Server

    Boxman, E W; ten Kate, H H J

    2002-01-01

    The B00 model coil has been successfully tested in the ATLAS Magnet Test Facility at CERN. The coil consists of two double pancakes wound with aluminum stabilized cables of the barrel- and end-cap toroids conductors for the ATLAS detector. The magnet current is applied up to 24 kA and quenches are induced by firing point heaters. The normal zone velocity is measured over a wide range of currents by using pickup coils, voltage taps and superconducting quench detectors. The signals coming from various sensors are presented and analyzed. The results extracted from the various detection methods are in good agreement. It is found that the characteristic velocities vary from 5 to 20 m/s at 15 and 24 kA respectively. In addition, the minimum quench energies at different applied magnet currents are presented. (6 refs).

  13. Robust modeling of differential gene expression data using normal/independent distributions: a Bayesian approach.

    Directory of Open Access Journals (Sweden)

    Mojtaba Ganjali

    Full Text Available In this paper, the problem of identifying differentially expressed genes under different conditions using gene expression microarray data, in the presence of outliers, is discussed. For this purpose, the robust modeling of gene expression data using some powerful distributions known as normal/independent distributions is considered. These distributions include the Student's t and normal distributions which have been used previously, but also include extensions such as the slash, the contaminated normal and the Laplace distributions. The purpose of this paper is to identify differentially expressed genes by considering these distributional assumptions instead of the normal distribution. A Bayesian approach using the Markov Chain Monte Carlo method is adopted for parameter estimation. Two publicly available gene expression data sets are analyzed using the proposed approach. The use of the robust models for detecting differentially expressed genes is investigated. This investigation shows that the choice of model for differentiating gene expression data is very important. This is due to the small number of replicates for each gene and the existence of outlying data. Comparison of the performance of these models is made using different statistical criteria and the ROC curve. The method is illustrated using some simulation studies. We demonstrate the flexibility of these robust models in identifying differentially expressed genes.

  14. BALANCED SCORECARDS EVALUATION MODEL THAT INCLUDES ELEMENTS OF ENVIRONMENTAL MANAGEMENT SYSTEM USING AHP MODEL

    Directory of Open Access Journals (Sweden)

    Jelena Jovanović

    2010-03-01

    Full Text Available The research is oriented on improvement of environmental management system (EMS using BSC (Balanced Scorecard model that presents strategic model of measurem ents and improvement of organisational performance. The research will present approach of objectives and environmental management me trics involvement (proposed by literature review in conventional BSC in "Ad Barska plovi dba" organisation. Further we will test creation of ECO-BSC model based on business activities of non-profit organisations in order to improve envir onmental management system in parallel with other systems of management. Using this approach we may obtain 4 models of BSC that includ es elements of environmen tal management system for AD "Barska plovidba". Taking into acc ount that implementation and evaluation need long period of time in AD "Barska plovidba", the final choice will be based on 14598 (Information technology - Software product evaluation and ISO 9126 (Software engineering - Product quality using AHP method. Those standards are usually used for evaluation of quality software product and computer programs that serve in organisation as support and factors for development. So, AHP model will be bas ed on evolution criteria based on suggestion of ISO 9126 standards and types of evaluation from two evaluation teams. Members of team & will be experts in BSC and environmental management system that are not em ployed in AD "Barska Plovidba" organisation. The members of team 2 will be managers of AD "Barska Plovidba" organisation (including manage rs from environmental department. Merging results based on previously cr eated two AHP models, one can obtain the most appropriate BSC that includes elements of environmental management system. The chosen model will present at the same time suggestion for approach choice including ecological metrics in conventional BSC model for firm that has at least one ECO strategic orientation.

  15. Information Criteria for Deciding between Normal Regression Models

    CERN Document Server

    Maier, Robert S

    2013-01-01

    Regression models fitted to data can be assessed on their goodness of fit, though models with many parameters should be disfavored to prevent over-fitting. Statisticians' tools for this are little known to physical scientists. These include the Akaike Information Criterion (AIC), a penalized goodness-of-fit statistic, and the AICc, a variant including a small-sample correction. They entered the physical sciences through being used by astrophysicists to compare cosmological models; e.g., predictions of the distance-redshift relation. The AICc is shown to have been misapplied, being applicable only if error variances are unknown. If error bars accompany the data, the AIC should be used instead. Erroneous applications of the AICc are listed in an appendix. It is also shown how the variability of the AIC difference between models with a known error variance can be estimated. This yields a significance test that can potentially replace the use of `Akaike weights' for deciding between such models. Additionally, the...

  16. Log-normal censored regression model detecting prognostic factors in gastric cancer: A study of 3018 cases

    Institute of Scientific and Technical Information of China (English)

    Bin-Bin Wang; Cai-Gang Liu; Ping Lu; A Latengbaolide; Yang Lu

    2011-01-01

    AIM: To investigate the efficiency of Cox proportional hazard model in detecting prognostic factors for gastric cancer.METHODS: We used the log-normal regression model to evaluate prognostic factors in gastric cancer and compared it with the Cox model. Three thousand and eighteen gastric cancer patients who received a gastrectomy between 1980 and 2004 were retrospectively evaluated. Clinic-pathological factors were included in a log-normal model as well as Cox model. The akaike information criterion (AIC) was employed to compare the efficiency of both models. Univariate analysis indicated that age at diagnosis, past history, cancer location, distant metastasis status, surgical curative degree, combined other organ resection, Borrmann type, Lauren's classification, pT stage, total dissected nodes and pN stage were prognostic factors in both log-normal and Cox models.RESULTS: In the final multivariate model, age at diagnosis,past history, surgical curative degree, Borrmann type, Lauren's classification, pT stage, and pN stage were significant prognostic factors in both log-normal and Cox models. However, cancer location, distant metastasis status, and histology types were found to be significant prognostic factors in log-normal results alone.According to AIC, the log-normal model performed better than the Cox proportional hazard model (AIC value:2534.72 vs 1693.56).CONCLUSION: It is suggested that the log-normal regression model can be a useful statistical model to evaluate prognostic factors instead of the Cox proportional hazard model.

  17. Including operational data in QMRA model: development and impact of model inputs.

    Science.gov (United States)

    Jaidi, Kenza; Barbeau, Benoit; Carrière, Annie; Desjardins, Raymond; Prévost, Michèle

    2009-03-01

    A Monte Carlo model, based on the Quantitative Microbial Risk Analysis approach (QMRA), has been developed to assess the relative risks of infection associated with the presence of Cryptosporidium and Giardia in drinking water. The impact of various approaches for modelling the initial parameters of the model on the final risk assessments is evaluated. The Monte Carlo simulations that we performed showed that the occurrence of parasites in raw water was best described by a mixed distribution: log-Normal for concentrations > detection limit (DL), and a uniform distribution for concentrations risks significantly. The mean annual risks for conventional treatment are: 1.97E-03 (removal credit adjusted by log parasite = log spores), 1.58E-05 (log parasite = 1.7 x log spores) or 9.33E-03 (regulatory credits based on the turbidity measurement in filtered water). Using full scale validated SCADA data, the simplified calculation of CT performed at the plant was shown to largely underestimate the risk relative to a more detailed CT calculation, which takes into consideration the downtime and system failure events identified at the plant (1.46E-03 vs. 3.93E-02 for the mean risk).

  18. Voxel-based evidence of perfusion normalization in glioblastoma patients included in a phase I-II trial of radiotherapy/tipifarnib combination.

    Science.gov (United States)

    Ken, Soléakhéna; Deviers, Alexandra; Filleron, Thomas; Catalaa, Isabelle; Lotterie, Jean-Albert; Khalifa, Jonathan; Lubrano, Vincent; Berry, Isabelle; Péran, Patrice; Celsis, Pierre; Moyal, Elizabeth Cohen-Jonathan; Laprie, Anne

    2015-09-01

    We previously showed that the farnesyl transferase inihibitor, Tipifarnib induced vascularization normalization, oxygenation and radiosensitization in a pre-clinical glioblastoma (GBM) model. The aim of this study was to assess by dynamic-susceptibility-contrast MRI (DSC-MRI) the effect of radiotherapy (RT) and Tipifarnib combination on tumor perfusion in GBM patients. Eighteen patients with newly diagnosed GBM, enrolled in a phase I-II clinical trial associating RT with Tipifarnib, underwent anatomical MR imaging and DSC-MRI before (M0) and two months after treatment (M2). Anatomic volumes of interest (VOIs) were delineated according to contrast-enhanced and hyper-intense signal areas on T1-Gd and T2 images, respectively. Perfusion variations between M0 and M2 were assessed with median relative cerebral blood volume (rCBV) inside these VOIs. Another voxel by voxel analysis of CBV values classified 405,117 tumor voxels into High_, Normal_ and Low_CBVTUMOR according to the distribution of CBV in the contralateral normal tissue. These three categories of CBVTUMOR voxels were color-coded over anatomical MRI. Variations of median rCBV were significantly different for two groups of patients (P  1) and rCBV increased when initial rCBV was color-coded voxels provided additional spatial and quantitative information about tumor perfusion: Group_rCBV_M0 > 1 presented a significant decrease of High_CBVTUMOR volume (P = 0.015) simultaneously with a significant increase of Normal_CBVTUMOR volume (P = 0.009) after treatment. Group_rCBV_M0 perfusion evolution in GBM patients treated with RT combined to Tipifarnib; showing variations in favour of tumor perfusion normalization in agreement with our pre-clinical results of vascular normalization.

  19. Identifiability of Normal and Normal Mixture Models With Nonignorable Missing Data

    OpenAIRE

    Miao, Wang; Ding, Peng; Geng, Zhi

    2015-01-01

    Missing data problems arise in many applied research studies. They may jeopardize statistical inference of the model of interest, if the missing mechanism is nonignorable, that is, the missing mechanism depends on the missing values themselves even conditional on the observed data. With a nonignorable missing mechanism, the model of interest is often not identifiable without imposing further assumptions. We find that even if the missing mechanism has a known parametric form, the model is not ...

  20. Steady state cooling flow models with gas loss for normal elliptical galaxies

    Science.gov (United States)

    Sarazin, Craig L.; Ashe, Gregory A.

    1989-01-01

    A grid of cooling flow models for the hot gas in normal elliptical galaxies is calculated, including the loss of gas due to inhomogeneous cooling. The loss process is modeled as a distributed sink for the gas with the rate of loss being proportional to the local cooling rate. The cooling flow models with gas loss have smaller sonic radii, smaller inflow rates in their central regions, lower densities, and higher temperatures than homogeneous models. The reduction in the amount of hot gas flowing into the center of the models brings the models into much better agreement with the observed X-ray surface brightness profiles of elliptical galaxies. However, there is a large dispersion in the observed X-ray luminosities of ellipticals, and this cannot be explained by variations in the efficiency of gas loss. The gas-loss models have X-ray surface brightness profiles which are much less centrally peaked than the no-gas-loss models.

  1. Smart Voyage Planning Model Sensitivity Analysis Using Ocean and Atmospheric Models Including Ensemble Methods

    Science.gov (United States)

    2012-09-01

    ATMOSPHERIC MODELS INCLUDING ENSEMBLE METHODS Scott E. Miller Lieutenant Commander, United States Navy B.S., University of South Carolina, 2000 B.S...Typical gas turbine fuel consumption curve and relationship to sea state .......51  Figure 16.  DDG 58 speed reduction curves for bow seas...Day Time Group ECDIS-N Electronic Chart Display and Information System – Navy ECMWF European Center for Medium Range Weather Forecasts EFAS

  2. A model predicting fluindione dose requirement in elderly inpatients including genotypes, body weight, and amiodarone.

    Science.gov (United States)

    Moreau, Caroline; Pautas, Eric; Duverlie, Charlotte; Berndt, Celia; Andro, Marion; Mahé, Isabelle; Emmerich, Joseph; Lacut, Karine; Le Gal, Grégoire; Peyron, Isabelle; Gouin-Thibault, Isabelle; Golmard, Jean-Louis; Loriot, Marie-Anne; Siguret, Virginie

    2014-04-01

    Indandione VKAs have been widely used for decades, especially in Eastern Europe and France. Contrary to coumarin VKAs, the relative contribution of individual factors to the indandione-VKA response is poorly known. In the present multicentre study, we sought to develop and validate a model including genetic and non-genetic factors to predict the daily fluindione dose requirement in elderly patients in whom VKA dosing is challenging. We prospectively recorded clinical and therapeutic data in 230 Caucasian inpatients mean aged 85 ± 6 years, who had reached international normalized ratio stabilisation (range 2.0-3.0) on fluindione. In the derivation cohort (n=156), we analysed 13 polymorphisms in seven genes potentially involved in the pharmacological effect or vitamin-K cycle (VKORC1, CYP4F2, EPHX1) and fluindione metabolism/transport (CYP2C9, CYP2C19, CYP3A5, ABCB1). We built a regression model incorporating non-genetic and genetic data and evaluated the model performances in a separate cohort (n=74).Body-weight, amiodarone intake, VKORC1, CYP4F2, ABCB1 genotypes were retained in the final model, accounting for 31.5% of dose variability. None influence of CYP2C9 was observed. Our final model showed good performances: in 83.3% of the validation cohort patients, the dose was accurately predicted within 5 mg, i.e.the usual step used for adjusting fluindione dosage. In conclusion, in addition to body-weight and amiodarone-intake, pharmacogenetic factors (VKORC1, CYP4F2, ABCB1) related to the pharmacodynamic effect and transport of fluindione significantly influenced the dose requirement in elderly patients while CYP2C9 did not. Studies are required to know whether fluindione could be an alternative VKA in carriers of polymorphic CYP2C9 alleles, hypersensitive to coumarins.

  3. ASYMPTOTIC NORMALITY OF QUASI MAXIMUM LIKELIHOOD ESTIMATE IN GENERALIZED LINEAR MODELS

    Institute of Scientific and Technical Information of China (English)

    YUE LI; CHEN XIRU

    2005-01-01

    For the Generalized Linear Model (GLM), under some conditions including that the specification of the expectation is correct, it is shown that the Quasi Maximum Likelihood Estimate (QMLE) of the parameter-vector is asymptotic normal. It is also shown that the asymptotic covariance matrix of the QMLE reaches its minimum (in the positive-definte sense) in case that the specification of the covariance matrix is correct.

  4. Modeling Radiotherapy Induced Normal Tissue Complications: An Overview beyond Phenomenological Models

    Science.gov (United States)

    Benassi, Marcello; Strigari, Lidia

    2016-01-01

    An overview of radiotherapy (RT) induced normal tissue complication probability (NTCP) models is presented. NTCP models based on empirical and mechanistic approaches that describe a specific radiation induced late effect proposed over time for conventional RT are reviewed with particular emphasis on their basic assumptions and related mathematical translation and their weak and strong points. PMID:28044088

  5. Extending the Concepts of Normalization from Relational Databases to Extensible-Markup-Language Databases Model

    Directory of Open Access Journals (Sweden)

    H.J. F. El-Sofany

    2008-01-01

    Full Text Available In this study we have studied the problem of how to extend the concepts of Functional Dependency (FD and normalization in relational databases to include the eXtensible Markup Language (XML model. We shown that, like relational databases, XML documents may contain redundant information and this redundancy may cause update anomalies. Furthermore, such problems are caused by certain functional dependencies among paths in the document. Our goal is to find a way for converting an arbitrary XML Schema to a well-designed one, that avoids these problems. We introduced new definitions of FD and normal forms of XML Schema (X-1NF, X-2NF, X-3NF and X-BCNF. We shown that our normal forms are necessary and sufficient to ensure all conforming XML documents have no redundancies.

  6. Identification of Daqingye and Banlangen including crude drugs and decoction dregs from three plant species by normal light and fluorescence microscopy.

    Science.gov (United States)

    Xiaojing, Wan; Liang, Zhitao; Chen, Hu-Biao; Zhao, Zhongzhen; Li, Ping

    2013-08-01

    Daqingye and Banlangen are commonly used Chinese medicinal materials derived from the leaves and roots of Isatis indigotica Fort., respectively, which clinical effects have been confirmed by many studies in recent years. However, many problems have arisen concerning the quality and identity of materials sold in the market under these two names. Thus, the identification of Daqingye and Banlangen has drawn public attention. In this work, transverse sections of Daqingye and Banlangen from I. indigotica Fort. and two easily confused species, namely Baphicacanthus cusia (Nees) Bremek. and Clerodendrum cyrtophyllum Turcz., were investigated with normal light and fluorescence microscopy. The distinguishing features were 7-9 vascular bundles, cystoliths and nonglandular hairs in the leaves of I. indigotica, B. cusia, and C. cyrtophyllum, respectively. The Banlangen could be distinguished according to the characteristics of parenchymous cells, cystoliths, and stone cells. Moreover, the fluorescence features of Daqingye and Banlangen investigated in this study can provide direct points for differentiating those samples. Importantly, whether the crude drugs were decocted could be easily identified by their different fluorescence features, which can ensure their quality in clinical application. This is the first report to distinguish the three species that are commonly found in the market sold as Daqingye and Banlangen by normal light and fluorescence microscopy. This work indicates that the combination of normal light and fluorescence microscopy could be powerful, convenient, and economical for authenticating Daqingye and Banlangen from the three species, including crude drugs and decoction dregs.

  7. Modeling cardiac β-adrenergic signaling with normalized-Hill differential equations: comparison with a biochemical model

    Directory of Open Access Journals (Sweden)

    Saucerman Jeffrey J

    2010-11-01

    Full Text Available Abstract Background New approaches are needed for large-scale predictive modeling of cellular signaling networks. While mass action and enzyme kinetic approaches require extensive biochemical data, current logic-based approaches are used primarily for qualitative predictions and have lacked direct quantitative comparison with biochemical models. Results We developed a logic-based differential equation modeling approach for cell signaling networks based on normalized Hill activation/inhibition functions controlled by logical AND and OR operators to characterize signaling crosstalk. Using this approach, we modeled the cardiac β1-adrenergic signaling network, including 36 reactions and 25 species. Direct comparison of this model to an extensively characterized and validated biochemical model of the same network revealed that the new model gave reasonably accurate predictions of key network properties, even with default parameters. Normalized Hill functions improved quantitative predictions of global functional relationships compared with prior logic-based approaches. Comprehensive sensitivity analysis revealed the significant role of PKA negative feedback on upstream signaling and the importance of phosphodiesterases as key negative regulators of the network. The model was then extended to incorporate recently identified protein interaction data involving integrin-mediated mechanotransduction. Conclusions The normalized-Hill differential equation modeling approach allows quantitative prediction of network functional relationships and dynamics, even in systems with limited biochemical data.

  8. Improved Subseasonal Prediction with Advanced Coupled Models including the 30km FIM-HYCOM Coupled Model

    Science.gov (United States)

    Benjamin, Stan; Sun, Shan; Grell, Georg; Green, Benjamin; Bleck, Rainer; Li, Haiqin

    2017-04-01

    Extreme events for subseasonal duration have been linked to multi-week processes related to onset, duration, and cessation of blocking events or, more generally, quasi-stationary waves. Results will be shown from different sets of 32-day prediction experiments (3200 runs each) over a 16-year period for earth system processes key for subseasonal prediction for different resolution, numerics, and physics using the FIM-HYCOM coupled model. The coupled atmosphere (FIM) and ocean (HYCOM) modeling system is a relatively new coupled atmosphere-ocean model developed for subseasonal to seasonal prediction (Green et al. 2017 Mon.Wea.Rev. accepted, Bleck et al 2015 Mon. Wea. Rev.). Both component models operate on a common icosahedral horizontal grid and use an adaptive hybrid vertical coordinate (sigma-isentropic in FIM and sigma-isopycnic in HYCOM). FIM-HYCOM has been used to conduct 16 years of subseasonal retrospective forecasts following the NOAA Subseasonal (SubX) NMME protocol (32-day forward integrations), run with 4 ensemble members per week. Results from this multi-year FIM-HYCOM hindcast include successful forecasts out to 14-20 days for stratospheric warming events (from archived 10 hPa fields), improved MJO predictability (Green et al. 2017) using the Grell-Freitas (2014, ACP) scale-aware cumulus scheme instead of the Simplified Arakawa-Schubert scheme, and little sensitivity to resolution for blocking frequency. Forecast skill of metrics from FIM-HYCOM including 500 hPa heights and MJO index is at least comparable to that of the operational Climate Forecast System (CFSv2) used by the National Centers for Environmental Prediction. Subseasonal skill is improved with a limited multi-model (FIM-HYCOM and CFSv2), consistent with previous seasonal multi-model ensemble results. Ongoing work will also be reported on for adding inline aerosol/chemistry treatment to the coupled FIM-HYCOM model and for advanced approaches to subgrid-scale clouds to address regional biases

  9. The effect of ignoring individual heterogeneity in Weibull log-normal sire frailty models.

    Science.gov (United States)

    Damgaard, L H; Korsgaard, I R; Simonsen, J; Dalsgaard, O; Andersen, A H

    2006-06-01

    The objective of this study was, by means of simulation, to quantify the effect of ignoring individual heterogeneity in Weibull sire frailty models on parameter estimates and to address the consequences for genetic inferences. Three simulation studies were evaluated, which included 3 levels of individual heterogeneity combined with 4 levels of censoring (0, 25, 50, or 75%). Data were simulated according to balanced half-sib designs using Weibull log-normal animal frailty models with a normally distributed residual effect on the log-frailty scale. The 12 data sets were analyzed with 2 models: the sire model, equivalent to the animal model used to generate the data (complete sire model), and a corresponding model in which individual heterogeneity in log-frailty was neglected (incomplete sire model). Parameter estimates were obtained from a Bayesian analysis using Gibbs sampling, and also from the software Survival Kit for the incomplete sire model. For the incomplete sire model, the Monte Carlo and Survival Kit parameter estimates were similar. This study established that when unobserved individual heterogeneity was ignored, the parameter estimates that included sire effects were biased toward zero by an amount that depended in magnitude on the level of censoring and the size of the ignored individual heterogeneity. Despite the biased parameter estimates, the ranking of sires, measured by the rank correlations between true and estimated sire effects, was unaffected. In comparison, parameter estimates obtained using complete sire models were consistent with the true values used to simulate the data. Thus, in this study, several issues of concern were demonstrated for the incomplete sire model.

  10. Model-integrated estimation of normal tissue contamination for cancer SNP allelic copy number data.

    Science.gov (United States)

    Stjernqvist, Susann; Rydén, Tobias; Greenman, Chris D

    2011-01-01

    SNP allelic copy number data provides intensity measurements for the two different alleles separately. We present a method that estimates the number of copies of each allele at each SNP position, using a continuous-index hidden Markov model. The method is especially suited for cancer data, since it includes the fraction of normal tissue contamination, often present when studying data from cancer tumors, into the model. The continuous-index structure takes into account the distances between the SNPs, and is thereby appropriate also when SNPs are unequally spaced. In a simulation study we show that the method performs favorably compared to previous methods even with as much as 70% normal contamination. We also provide results from applications to clinical data produced using the Affymetrix genome-wide SNP 6.0 platform.

  11. An Elementary Test of the Normal 2PL Model against the Normal 3PL Alternative. Research Report. ETS RR-06-14

    Science.gov (United States)

    Haberman, Shelby J.

    2006-01-01

    A simple score test of the normal two-parameter logistic (2PL) model is presented that examines the potential attraction of the normal three-parameter logistic (3PL) model for use with a particular item. Application is made to data from a test from the Praxis™ series. Results from this example raise the question whether the normal 3PL model should…

  12. Option Pricing with Asymmetric Heteroskedastic Normal Mixture Models

    DEFF Research Database (Denmark)

    Rombouts, Jeroen V. K; Stentoft, Lars

    2015-01-01

    2011, and compute dollar losses and implied standard deviation losses. We compare our results to those of existing mixture models and other benchmarks like component models and jump models. Using the model confidence set test, the overall dollar root mean squared error of the best performing benchmark...

  13. Consistency and asymptotic normality of profilekernel and backfitting estimators in semiparametric reproductive dispersion nonlinear models

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Semiparametric reproductive dispersion nonlinear model (SRDNM) is an extension of nonlinear reproductive dispersion models and semiparametric nonlinear regression models, and includes semiparametric nonlinear model and semiparametric generalized linear model as its special cases. Based on the local kernel estimate of nonparametric component, profile-kernel and backfitting estimators of parameters of interest are proposed in SRDNM, and theoretical comparison of both estimators is also investigated in this paper. Under some regularity conditions, strong consistency and asymptotic normality of two estimators are proved. It is shown that the backfitting method produces a larger asymptotic variance than that for the profile-kernel method. A simulation study and a real example are used to illustrate the proposed methodologies.

  14. Bayesian Hierarchical Scale Mixtures of Log-Normal Models for Inference in Reliability with Stochastic Constraint

    Directory of Open Access Journals (Sweden)

    Hea-Jung Kim

    2017-06-01

    Full Text Available This paper develops Bayesian inference in reliability of a class of scale mixtures of log-normal failure time (SMLNFT models with stochastic (or uncertain constraint in their reliability measures. The class is comprehensive and includes existing failure time (FT models (such as log-normal, log-Cauchy, and log-logistic FT models as well as new models that are robust in terms of heavy-tailed FT observations. Since classical frequency approaches to reliability analysis based on the SMLNFT model with stochastic constraint are intractable, the Bayesian method is pursued utilizing a Markov chain Monte Carlo (MCMC sampling based approach. This paper introduces a two-stage maximum entropy (MaxEnt prior, which elicits a priori uncertain constraint and develops Bayesian hierarchical SMLNFT model by using the prior. The paper also proposes an MCMC method for Bayesian inference in the SMLNFT model reliability and calls attention to properties of the MaxEnt prior that are useful for method development. Finally, two data sets are used to illustrate how the proposed methodology works.

  15. A log-normal distribution model for the molecular weight of aquatic fulvic acids

    Science.gov (United States)

    Cabaniss, S.E.; Zhou, Q.; Maurice, P.A.; Chin, Y.-P.; Aiken, G.R.

    2000-01-01

    The molecular weight of humic substances influences their proton and metal binding, organic pollutant partitioning, adsorption onto minerals and activated carbon, and behavior during water treatment. We propose a lognormal model for the molecular weight distribution in aquatic fulvic acids to provide a conceptual framework for studying these size effects. The normal curve mean and standard deviation are readily calculated from measured M(n) and M(w) and vary from 2.7 to 3 for the means and from 0.28 to 0.37 for the standard deviations for typical aquatic fulvic acids. The model is consistent with several types of molecular weight data, including the shapes of high- pressure size-exclusion chromatography (HP-SEC) peaks. Applications of the model to electrostatic interactions, pollutant solubilization, and adsorption are explored in illustrative calculations.The molecular weight of humic substances influences their proton and metal binding, organic pollutant partitioning, adsorption onto minerals and activated carbon, and behavior during water treatment. We propose a log-normal model for the molecular weight distribution in aquatic fulvic acids to provide a conceptual framework for studying these size effects. The normal curve mean and standard deviation are readily calculated from measured Mn and Mw and vary from 2.7 to 3 for the means and from 0.28 to 0.37 for the standard deviations for typical aquatic fulvic acids. The model is consistent with several type's of molecular weight data, including the shapes of high-pressure size-exclusion chromatography (HP-SEC) peaks. Applications of the model to electrostatic interactions, pollutant solubilization, and adsorption are explored in illustrative calculations.

  16. The prevalence of polycystic ovary syndrome in a normal population according to the Rotterdam criteria versus revised criteria including anti-Mullerian hormone

    DEFF Research Database (Denmark)

    Lauritsen, Mette Petri; Bentzen, J G; Pinborg, Anja Bisgaard;

    2014-01-01

    STUDY QUESTION: What is the prevalence in a normal population of polycystic ovary syndrome (PCOS) according to the Rotterdam criteria versus revised criteria including anti-Müllerian hormone (AMH)? SUMMARY ANSWER: The prevalence of PCOS was 16.6% according to the Rotterdam criteria. When replacing...... the criterion for polycystic ovaries by antral follicle count (AFC) > 19 or AMH > 35 pmol/l, the prevalence of PCOS was 6.3 and 8.5%, respectively. WHAT IS KNOWN ALREADY?: The Rotterdam criteria state that two out of the following three criteria should be present in the diagnosis of PCOS: oligo......-anovulation, clinical and/or biochemical hyperandrogenism and polycystic ovaries (AFC ≥ 12 and/or ovarian volume >10 ml). However, with the advances in sonography, the relevance of the AFC threshold in the definition of polycystic ovaries has been challenged, and AMH has been proposed as a marker of polycystic ovaries...

  17. On application of optimal control to SEIR normalized models: Pros and cons.

    Science.gov (United States)

    de Pinho, Maria do Rosario; Nogueira, Filipa Nunes

    2017-02-01

    In this work we normalize a SEIR model that incorporates exponential natural birth and death, as well as disease-caused death. We use optimal control to control by vaccination the spread of a generic infectious disease described by a normalized model with L1 cost. We discuss the pros and cons of SEIR normalized models when compared with classical models when optimal control with L1 costs are considered. Our discussion highlights the role of the cost. Additionally, we partially validate our numerical solutions for our optimal control problem with normalized models using the Maximum Principle.

  18. A Probabilistic Model of Student Nurses' Knowledge of Normal Nutrition.

    Science.gov (United States)

    Passmore, David Lynn

    1983-01-01

    Vocational and technical education researchers need to be aware of the uses and limits of various statistical models. The author reviews the Rasch Model and applies it to results from a nutrition test given to student nurses. (Author)

  19. Some covariance models based on normal scale mixtures

    CERN Document Server

    Schlather, Martin

    2011-01-01

    Modelling spatio-temporal processes has become an important issue in current research. Since Gaussian processes are essentially determined by their second order structure, broad classes of covariance functions are of interest. Here, a new class is described that merges and generalizes various models presented in the literature, in particular models in Gneiting (J. Amer. Statist. Assoc. 97 (2002) 590--600) and Stein (Nonstationary spatial covariance functions (2005) Univ. Chicago). Furthermore, new models and a multivariate extension are introduced.

  20. Numerical investigations with a hybrid isentropic-sigma model. I - Normal-mode characteristics. II - The inclusion of moist processes

    Science.gov (United States)

    Pierce, R. B.; Johnson, Donald R.; Reames, Fred M.; Zapotocny, Tom H.; Wolf, Bart J.

    1991-01-01

    The normal-mode characteristics of baroclinically amplifying disturbances were numerically investigated in a series of adiabatic simulations by a hybrid isentropic-sigma model, demonstrating the effect of coupling an isentropic-coordinate free atmospheric domain with a sigma-coordinate PBL on the normal-mode characteristics. Next, the normal-mode model was modified by including a transport equation for water vapor and adiabatic heating by condensation. Simulations with and without a hydrological component showed that the overall effect of latent heat release is to markedly enhance cyclogenesis and frontogenesis.

  1. Zebrafish as a model for normal and malignant hematopoiesis

    Directory of Open Access Journals (Sweden)

    Lili Jing

    2011-07-01

    Full Text Available Zebrafish studies in the past two decades have made major contributions to our understanding of hematopoiesis and its associated disorders. The zebrafish has proven to be a powerful organism for studies in this area owing to its amenability to large-scale genetic and chemical screening. In addition, the externally fertilized and transparent embryos allow convenient genetic manipulation and in vivo imaging of normal and aberrant hematopoiesis. This review discusses available methods for studying hematopoiesis in zebrafish, summarizes key recent advances in this area, and highlights the current and potential contributions of zebrafish to the discovery and development of drugs to treat human blood disorders.

  2. A coupling model for quasi-normal modes of photonic resonators

    Science.gov (United States)

    Vial, Benjamin; Hao, Yang

    2016-11-01

    We develop a model for the coupling of quasi-normal modes in open photonic systems consisting of two resonators. By expressing the modes of the coupled system as a linear combination of the modes of the individual particles, we obtain a generalized eigenvalue problem involving small size dense matrices. We apply this technique to dielectric rod dimmer of rectangular cross section for transverse electric polarization in a two-dimensional setup. The results of our model show excellent agreement with full wave finite element simulations. We provide a convergence analysis, and a simplified model with a few modes to study the influence of the relative position of the two resonators. This model provides interesting physical insights on the coupling scheme at stake in such systems and pave the way for systematic and efficient design and optimization of resonances in more complicated systems, for applications including sensing, antennae and spectral filtering.

  3. Option Pricing with Asymmetric Heteroskedastic Normal Mixture Models

    DEFF Research Database (Denmark)

    Rombouts, Jeroen V.K.; Stentoft, Lars

    varying higher order moments of the risk neutral distribution. When forecasting out-of-sample a large set of index options between 1996 and 2009, substantial improvements are found compared to several benchmark models in terms of dollar losses and the ability to explain the smirk in implied volatilities....... Overall, the dollar root mean squared error of the best performing benchmark component model is 39% larger than for the mixture model. When considering the recent financial crisis this difference increases to 69%....

  4. Modeling consonant perception in normal-hearing listeners

    DEFF Research Database (Denmark)

    Zaar, Johannes; Jørgensen, Søren; Dau, Torsten

    2014-01-01

    -vowel combinations (CVs) in quiet and at 6 different SNRs in white noise. The responses were analyzed in terms of recognition scores and consonant confusions. Inspired by models designed for long-term (”macroscopic“) speech intelligibility prediction, two modeling concepts were considered to describe the consonant...... perception data: (i) an audibility-based approach, which corresponds to the Articu- lation Index (AI), and (ii) a modulation-masking based approach, as reflected in the speech-based Envelope Power Spectrum Model (sEPSM). For both models, the internal representations of the same stimuli as used......Speech perception is often studied in terms of natural meaningful speech, i.e., by measuring the in- telligibility of a given set of single words or full sentences. However, when trying to understand how background noise, various sorts of transmission channels (e.g., mobile phones) or hearing...

  5. ATEFlap aerodynamic model, a dynamic stall model including the effects of trailing edge flap deflection

    Energy Technology Data Exchange (ETDEWEB)

    Bergami, L.; Gaunaa, M.

    2012-02-15

    The report presents the ATEFlap aerodynamic model, which computes the unsteady lift, drag and moment on a 2D airfoil section equipped with Adaptive Trailing Edge Flap. The model captures the unsteady response related to the effects of the vorticity shed into the wake, and the dynamics of flow separation a thin-airfoil potential flow model is merged with a dynamic stall model of the Beddoes-Leishmann type. The inputs required by the model are steady data for lift, drag, and moment coefficients as function of angle of attack and flap deflection. Further steady data used by the Beddoes- Leishmann dynamic stall model are computed in an external preprocessor application, which gives the user the possibility to verify, and eventually correct, the steady data passed to the aerodynamic model. The ATEFlap aerodynamic model is integrated in the aeroelastic simulation tool HAWC2, thus al- lowing to simulate the response of a wind turbine with trailing edge flaps on the rotor. The algorithms used by the preprocessor, and by aerodynamic model are presented, and modifications to previous implementations of the aerodynamic model are briefly discussed. The performance and the validity of the model are verified by comparing the dynamic response computed by the ATEFlap with solutions from CFD simulations. (Author)

  6. Food addiction spectrum: a theoretical model from normality to eating and overeating disorders.

    Science.gov (United States)

    Piccinni, Armando; Marazziti, Donatella; Vanelli, Federica; Franceschini, Caterina; Baroni, Stefano; Costanzo, Davide; Cremone, Ivan Mirko; Veltri, Antonello; Dell'Osso, Liliana

    2015-01-01

    The authors comment on the recently proposed food addiction spectrum that represents a theoretical model to understand the continuum between several conditions ranging from normality to pathological states, including eating disorders and obesity, as well as why some individuals show a peculiar attachment to food that can become an addiction. Further, they review the possible neurobiological underpinnings of these conditions that include dopaminergic neurotransmission and circuits that have long been implicated in drug addiction. The aim of this article is also that at stimulating a debate regarding the possible model of a food (or eating) addiction spectrum that may be helpful towards the search of novel therapeutic approaches to different pathological states related to disturbed feeding or overeating.

  7. Importance of global aerosol modeling including secondary organic aerosol formed from monoterpene

    OpenAIRE

    Goto, Daisuke; Takemura, Toshihiko; Nakajima, Teruyuki

    2008-01-01

    A global three-dimensional aerosol transport-radiation model, coupled to an atmospheric general circulation model (AGCM), has been extended to improve the model process for organic aerosols, particularly secondary organic aerosols (SOA), and to estimate SOA contributions to direct and indirect radiative effects. Because the SOA formation process is complicated and unknown, the results in different model simulations include large differences. In this work, we simulate SOA production assuming v...

  8. MODEL ANALYSIS AND PARAMETER EXTRACTION FOR MOS CAPACITOR INCLUDING QUANTUM MECHANICAL EFFECTS

    Institute of Scientific and Technical Information of China (English)

    Hai-yan Jiang; Ping-wen Zhang

    2006-01-01

    The high frequency CV curves of MOS capacitor have been studied. It is shown that semiclassical model is a good approximation to quantum model and approaches to classical model when the oxide layer is thick. This conclusion provides us an efficient (semiclassical) model including quantum mechanical effects to do parameter extraction for ultrathi noxide device. Here the effective extracting strategy is designed and numerical experiments demonstrate the validity of the strategy.

  9. A coupling model for quasi-normal modes of photonic resonators

    CERN Document Server

    Vial, Benjamin

    2016-01-01

    We develop a model for the coupling of quasi-normal modes in open photonic systems consisting of two resonators. By expressing the modes of the coupled system as a linear combination of the modes of the individual particles, we obtain a generalized eigenvalue problem involving small size dense matrices. We apply this technique to a 2D problem of a high index rod dimmer of rectangular cross section for Transverse Electric (TE) polarization. The results of our model are compared with full-wave finite element simulations and show a good agreement for the four lowest eigenvalues by taking into account the two lowest eigenfrequencies of the isolated rods. This model provides interesting physical insights on the coupling scheme at stake in such systems and pave the way for the design and optimization of resonances in more complicated systems, including the engineering of metamaterial unit cells.

  10. Modeling consonant perception in normal-hearing listeners

    DEFF Research Database (Denmark)

    Zaar, Johannes; Jørgensen, Søren; Dau, Torsten

    2014-01-01

    in the experiment were calculated and fed into a template-matching back end. Using the experimental data as a reference, the resulting predictions of the two modeling approaches were compared and their respective suitability for the prediction of consonant perception was evaluated....

  11. A finite element model of the face including an orthotropic skin model under in vivo tension.

    Science.gov (United States)

    Flynn, Cormac; Stavness, Ian; Lloyd, John; Fels, Sidney

    2015-01-01

    Computer models of the human face have the potential to be used as powerful tools in surgery simulation and animation development applications. While existing models accurately represent various anatomical features of the face, the representation of the skin and soft tissues is very simplified. A computer model of the face is proposed in which the skin is represented by an orthotropic hyperelastic constitutive model. The in vivo tension inherent in skin is also represented in the model. The model was tested by simulating several facial expressions by activating appropriate orofacial and jaw muscles. Previous experiments calculated the change in orientation of the long axis of elliptical wounds on patients' faces for wide opening of the mouth and an open-mouth smile (both 30(o)). These results were compared with the average change of maximum principal stress direction in the skin calculated in the face model for wide opening of the mouth (18(o)) and an open-mouth smile (25(o)). The displacements of landmarks on the face for four facial expressions were compared with experimental measurements in the literature. The corner of the mouth in the model experienced the largest displacement for each facial expression (∼11-14 mm). The simulated landmark displacements were within a standard deviation of the measured displacements. Increasing the skin stiffness and skin tension generally resulted in a reduction in landmark displacements upon facial expression.

  12. A global shear velocity model of the mantle from normal modes and surface waves

    Science.gov (United States)

    durand, S.; Debayle, E.; Ricard, Y. R.; Lambotte, S.

    2013-12-01

    We present a new global shear wave velocity model of the mantle based on the inversion of all published normal mode splitting functions and the large surface wave dataset measured by Debayle & Ricard (2012). Normal mode splitting functions and surface wave phase velocity maps are sensitive to lateral heterogeneities of elastic parameters (Vs, Vp, xi, phi, eta) and density. We first only consider spheroidal modes and Rayleigh waves and restrict the inversion to Vs, Vp and the density. Although it is well known that Vs is the best resolved parameter, we also investigate whether our dataset allows to extract additional information on density and/or Vp. We check whether the determination of the shear wave velocity is affected by the a priori choice of the crustal model (CRUST2.0 or 3SMAC) or by neglecting/coupling poorly resolved parameters. We include the major discontinuities, at 400 and 670 km. Vertical smoothing is imposed through an a priori gaussian covariance matrix on the model and we discuss the effect of coupling/decoupling the inverted structure above and below the discontinuities. We finally discuss the large scale structure of our model and its geodynamical implications regarding the amount of mass exchange between the upper and lower mantle.

  13. Presenting Thin Media Models Affects Women's Choice of Diet or Normal Snacks

    Science.gov (United States)

    Krahe, Barbara; Krause, Christina

    2010-01-01

    Our study explored the influence of thin- versus normal-size media models and of self-reported restrained eating behavior on women's observed snacking behavior. Fifty female undergraduates saw a set of advertisements for beauty products showing either thin or computer-altered normal-size female models, allegedly as part of a study on effective…

  14. 2-D Model for Normal and Sickle Cell Blood Microcirculation

    Science.gov (United States)

    Tekleab, Yonatan; Harris, Wesley

    2011-11-01

    Sickle cell disease (SCD) is a genetic disorder that alters the red blood cell (RBC) structure and function such that hemoglobin (Hb) cannot effectively bind and release oxygen. Previous computational models have been designed to study the microcirculation for insight into blood disorders such as SCD. Our novel 2-D computational model represents a fast, time efficient method developed to analyze flow dynamics, O2 diffusion, and cell deformation in the microcirculation. The model uses a finite difference, Crank-Nicholson scheme to compute the flow and O2 concentration, and the level set computational method to advect the RBC membrane on a staggered grid. Several sets of initial and boundary conditions were tested. Simulation data indicate a few parameters to be significant in the perturbation of the blood flow and O2 concentration profiles. Specifically, the Hill coefficient, arterial O2 partial pressure, O2 partial pressure at 50% Hb saturation, and cell membrane stiffness are significant factors. Results were found to be consistent with those of Le Floch [2010] and Secomb [2006].

  15. Hot DA white dwarf model atmosphere calculations: Including improved Ni PI cross sections

    CERN Document Server

    Preval, S P; Badnell, N R; Hubeny, I; Holberg, J B

    2016-01-01

    To calculate realistic models of objects with Ni in their atmospheres, accurate atomic data for the relevant ionization stages needs to be included in model atmosphere calculations. In the context of white dwarf stars, we investigate the effect of changing the Ni {\\sc iv}-{\\sc vi} bound-bound and bound-free atomic data has on model atmosphere calculations. Models including PICS calculated with {\\sc autostructure} show significant flux attenuation of up to $\\sim 80$\\% shortward of 180\\AA\\, in the EUV region compared to a model using hydrogenic PICS. Comparatively, models including a larger set of Ni transitions left the EUV, UV, and optical continua unaffected. We use models calculated with permutations of this atomic data to test for potential changes to measured metal abundances of the hot DA white dwarf G191-B2B. Models including {\\sc autostructure} PICS were found to change the abundances of N and O by as much as $\\sim 22$\\% compared to models using hydrogenic PICS, but heavier species were relatively unaf...

  16. Mathematical Model of Thyristor Inverter Including a Series-parallel Resonant Circuit

    Directory of Open Access Journals (Sweden)

    Miroslaw Luft

    2008-01-01

    Full Text Available The article presents a mathematical model of thyristor inverter including a series-parallel resonant circuit with theaid of state variable method. Maple procedures are used to compute current and voltage waveforms in the inverter.

  17. Complete Loss and Thermal Model of Power Semiconductors Including Device Rating Information

    DEFF Research Database (Denmark)

    Ma, Ke; Bahman, Amir Sajjad; Beczkowski, Szymon;

    2015-01-01

    loading but also the device rating as input variables. The quantified correlation between the power loss, thermal impedance and silicon area of Insulated Gate Bipolar Transistor (IGBT) is mathematically established. By this new modeling approach, all factors that have impacts to the loss and thermal......Thermal loading of power devices are closely related to the reliability performance of the whole converter system. The electrical loading and device rating are both important factors that determine the loss and thermal behaviors of power semiconductor devices. In the existing loss and thermal...... models, only the electrical loadings are focused and treated as design variables, while the device rating is normally pre-defined by experience with limited design flexibility. Consequently, a more complete loss and thermal model is proposed in this paper, which takes into account not only the electrical...

  18. Loss and thermal model for power semiconductors including device rating information

    DEFF Research Database (Denmark)

    Ma, Ke; Bahman, Amir Sajjad; Beczkowski, Szymon;

    2014-01-01

    The electrical loading and device rating are both important factors that determine the loss and thermal behaviors of power semiconductor devices. In the existing loss and thermal models, only the electrical loadings are focused and treated as design variables, while the device rating is normally...... pre-defined by experience with poor design flexibility. Consequently a more complete loss and thermal model is proposed in this paper, which takes into account not only the electrical loading but also the device rating as input variables. The quantified correlation between the power loss, thermal...... impedance and silicon area of Insulated Gate Bipolar Transistor (IGBT) is mathematically established. By this new modeling approach, all factors that have impacts to the loss and thermal profiles of power devices can be accurately mapped, enabling more design freedom to optimize the efficiency and thermal...

  19. Complete Loss and Thermal Model of Power Semiconductors Including Device Rating Information

    DEFF Research Database (Denmark)

    Ma, Ke; Bahman, Amir Sajjad; Beczkowski, Szymon

    2015-01-01

    profiles of the power devices can accurately be mapped, enabling more design freedom to optimize the efficiency and thermal loading of the power converter. The proposed model can be further improved by experimental tests, and it is well agreed by both circuit and Finite Element Method (FEM) simulation......Thermal loading of power devices are closely related to the reliability performance of the whole converter system. The electrical loading and device rating are both important factors that determine the loss and thermal behaviors of power semiconductor devices. In the existing loss and thermal...... models, only the electrical loadings are focused and treated as design variables, while the device rating is normally pre-defined by experience with limited design flexibility. Consequently, a more complete loss and thermal model is proposed in this paper, which takes into account not only the electrical...

  20. Loss and thermal model for power semiconductors including device rating information

    DEFF Research Database (Denmark)

    Ma, Ke; Bahman, Amir Sajjad; Beczkowski, Szymon

    2014-01-01

    impedance and silicon area of Insulated Gate Bipolar Transistor (IGBT) is mathematically established. By this new modeling approach, all factors that have impacts to the loss and thermal profiles of power devices can be accurately mapped, enabling more design freedom to optimize the efficiency and thermal......The electrical loading and device rating are both important factors that determine the loss and thermal behaviors of power semiconductor devices. In the existing loss and thermal models, only the electrical loadings are focused and treated as design variables, while the device rating is normally...... pre-defined by experience with poor design flexibility. Consequently a more complete loss and thermal model is proposed in this paper, which takes into account not only the electrical loading but also the device rating as input variables. The quantified correlation between the power loss, thermal...

  1. A Verilog-A large signal model for InP DHBT including thermal effects

    Science.gov (United States)

    Yuxia, Shi; Zhi, Jin; Zhijian, Pan; Yongbo, Su; Yuxiong, Cao; Yan, Wang

    2013-06-01

    A large signal model for InP/InGaAs double heterojunction bipolar transistors including thermal effects has been reported, which demonstrated good agreements of simulations with measurements. On the basis of the previous model in which the double heterojunction effect, current blocking effect and high current effect in current expression are considered, the effect of bandgap narrowing with temperature has been considered in transport current while a formula for model parameters as a function of temperature has been developed. This model is implemented by Verilog-A and embedded in ADS. The proposed model is verified with DC and large signal measurements.

  2. Modelling Mediterranean agro-ecosystems by including agricultural trees in the LPJmL model

    Science.gov (United States)

    Fader, M.; von Bloh, W.; Shi, S.; Bondeau, A.; Cramer, W.

    2015-11-01

    In the Mediterranean region, climate and land use change are expected to impact on natural and agricultural ecosystems by warming, reduced rainfall, direct degradation of ecosystems and biodiversity loss. Human population growth and socioeconomic changes, notably on the eastern and southern shores, will require increases in food production and put additional pressure on agro-ecosystems and water resources. Coping with these challenges requires informed decisions that, in turn, require assessments by means of a comprehensive agro-ecosystem and hydrological model. This study presents the inclusion of 10 Mediterranean agricultural plants, mainly perennial crops, in an agro-ecosystem model (Lund-Potsdam-Jena managed Land - LPJmL): nut trees, date palms, citrus trees, orchards, olive trees, grapes, cotton, potatoes, vegetables and fodder grasses. The model was successfully tested in three model outputs: agricultural yields, irrigation requirements and soil carbon density. With the development presented in this study, LPJmL is now able to simulate in good detail and mechanistically the functioning of Mediterranean agriculture with a comprehensive representation of ecophysiological processes for all vegetation types (natural and agricultural) and in a consistent framework that produces estimates of carbon, agricultural and hydrological variables for the entire Mediterranean basin. This development paves the way for further model extensions aiming at the representation of alternative agro-ecosystems (e.g. agroforestry), and opens the door for a large number of applications in the Mediterranean region, for example assessments of the consequences of land use transitions, the influence of management practices and climate change impacts.

  3. Modelling Mediterranean agro-ecosystems by including agricultural trees in the LPJmL model

    Directory of Open Access Journals (Sweden)

    M. Fader

    2015-06-01

    Full Text Available Climate and land use change in the Mediterranean region is expected to affect natural and agricultural ecosystems by decreases in precipitation, increases in temperature as well as biodiversity loss and anthropogenic degradation of natural resources. Demographic growth in the Eastern and Southern shores will require increases in food production and put additional pressure on agro-ecosystems and water resources. Coping with these challenges requires informed decisions that, in turn, require assessments by means of a comprehensive agro-ecosystem and hydrological model. This study presents the inclusion of 10 Mediterranean agricultural plants, mainly perennial crops, in an agro-ecosystem model (LPJmL: nut trees, date palms, citrus trees, orchards, olive trees, grapes, cotton, potatoes, vegetables and fodder grasses. The model was successfully tested in three model outputs: agricultural yields, irrigation requirements and soil carbon density. With the development presented in this study, LPJmL is now able to simulate in good detail and mechanistically the functioning of Mediterranean agriculture with a comprehensive representation of ecophysiological processes for all vegetation types (natural and agricultural and in a consistent framework that produces estimates of carbon, agricultural and hydrological variables for the entire Mediterranean basin. This development pave the way for further model extensions aiming at the representation of alternative agro-ecosystems (e.g. agroforestry, and opens the door for a large number of applications in the Mediterranean region, for example assessments on the consequences of land use transitions, the influence of management practices and climate change impacts.

  4. Numerical Acoustic Models Including Viscous and Thermal losses: Review of Existing and New Methods

    DEFF Research Database (Denmark)

    Andersen, Peter Risby; Cutanda Henriquez, Vicente; Aage, Niels

    2017-01-01

    This work presents an updated overview of numerical methods including acoustic viscous and thermal losses. Numerical modelling of viscothermal losses has gradually become more important due to the general trend of making acoustic devices smaller. Not including viscothermal acoustic losses in such...

  5. Bayesian CMB foreground separation with a correlated log-normal model

    CERN Document Server

    Oppermann, Niels

    2014-01-01

    The extraction of foreground and CMB maps from multi-frequency observations relies mostly on the different frequency behavior of the different components. Existing Bayesian methods additionally make use of a Gaussian prior for the CMB whose correlation structure is described by an unknown angular power spectrum. We argue for the natural extension of this by using non-trivial priors also for the foreground components. Focusing on diffuse Galactic foregrounds, we propose a log-normal model including unknown spatial correlations within each component and cross-correlations between the different foreground components. We present case studies at low resolution that demonstrate the superior performance of this model when compared to an analysis with flat priors for all components.

  6. Catalytic conversion of lignin pyrolysis model compound- guaiacol and its kinetic model including coke formation

    Science.gov (United States)

    Zhang, Huiyan; Wang, Yun; Shao, Shanshan; Xiao, Rui

    2016-11-01

    Lignin is the most difficult to be converted and most easy coking component in biomass catalytic pyrolysis to high-value liquid fuels and chemicals. Catalytic conversion of guaiacol as a lignin model compound was conducted in a fixed-bed reactor over ZSM-5 to investigate its conversion and coking behaviors. The effects of temperature, weight hourly space velocity (WHSV) and partial pressure on product distribution were studied. The results show the maximum aromatic carbon yield of 28.55% was obtained at temperature of 650 °C, WHSV of 8 h‑1 and partial pressure of 2.38 kPa, while the coke carbon yield was 19.55%. The reaction pathway was speculated to be removing methoxy group to form phenols with further aromatization to form aromatics. The amount of coke increased with increasing reaction time. The surface area and acidity of catalysts declined as coke formed on the acid sites and blocked the pore channels, which led to the decrease of aromatic yields. Finally, a kinetic model of guaiacol catalytic conversion considering coke deposition was built based on the above reaction pathway to properly predict product distribution. The experimental and model predicting data agreed well. The correlation coefficient of all equations were all higher than 0.90.

  7. Nonlinear Modeling of a High Precision Servo Injection Molding Machine Including Novel Molding Approach

    Institute of Scientific and Technical Information of China (English)

    何雪松; 王旭永; 冯正进; 章志新; 杨钦廉

    2003-01-01

    A nonlinear mathematical model of the injection molding process for electrohydraulic servo injection molding machine (IMM) is developed.It was found necessary to consider the characteristics of asymmetric cylinder for electrohydraulic servo IMM.The model is based on the dynamics of the machine including servo valve,asymmetric cylinder and screw,and the non-Newtonian flow behavior of polymer melt in injection molding is also considered.The performance of the model was evaluated based on novel approach of molding - injection and compress molding,and the results of simulation and experimental data demonstrate the effectiveness of the model.

  8. a Better Description of Liquid Jet Breakup Using a Spatial Model Including Viscous Effects.

    Science.gov (United States)

    Hammerschlag, William Brian

    Theoretical models describing the operation and disintegration of a liquid jet are often based on an approximate solution of an inviscid jet in the temporal frame of reference. These models provide only a fair first order prediction of growth rate and breakoff length, and are based solely on a surface tension induced instability. A spatial model yielding jet growth rate and including both jet and surrounding atmosphere viscosity and density is now developed. This model is seen to reproduce all the features and limitations of the Weber viscous jet theory. When tested against experiments of water, water and glycerol mixes and binary eutectic tin/lead solder, only fair agreement is observed.

  9. Notes on power of normality tests of error terms in regression models

    Energy Technology Data Exchange (ETDEWEB)

    Střelec, Luboš [Department of Statistics and Operation Analysis, Faculty of Business and Economics, Mendel University in Brno, Zemědělská 1, Brno, 61300 (Czech Republic)

    2015-03-10

    Normality is one of the basic assumptions in applying statistical procedures. For example in linear regression most of the inferential procedures are based on the assumption of normality, i.e. the disturbance vector is assumed to be normally distributed. Failure to assess non-normality of the error terms may lead to incorrect results of usual statistical inference techniques such as t-test or F-test. Thus, error terms should be normally distributed in order to allow us to make exact inferences. As a consequence, normally distributed stochastic errors are necessary in order to make a not misleading inferences which explains a necessity and importance of robust tests of normality. Therefore, the aim of this contribution is to discuss normality testing of error terms in regression models. In this contribution, we introduce the general RT class of robust tests for normality, and present and discuss the trade-off between power and robustness of selected classical and robust normality tests of error terms in regression models.

  10. TU-CD-BRB-01: Normal Lung CT Texture Features Improve Predictive Models for Radiation Pneumonitis

    Energy Technology Data Exchange (ETDEWEB)

    Krafft, S [The University of Texas MD Anderson Cancer Center, Houston, TX (United States); The University of Texas Graduate School of Biomedical Sciences, Houston, TX (United States); Briere, T; Court, L; Martel, M [The University of Texas MD Anderson Cancer Center, Houston, TX (United States)

    2015-06-15

    Purpose: Existing normal tissue complication probability (NTCP) models for radiation pneumonitis (RP) traditionally rely on dosimetric and clinical data but are limited in terms of performance and generalizability. Extraction of pre-treatment image features provides a potential new category of data that can improve NTCP models for RP. We consider quantitative measures of total lung CT intensity and texture in a framework for prediction of RP. Methods: Available clinical and dosimetric data was collected for 198 NSCLC patients treated with definitive radiotherapy. Intensity- and texture-based image features were extracted from the T50 phase of the 4D-CT acquired for treatment planning. A total of 3888 features (15 clinical, 175 dosimetric, and 3698 image features) were gathered and considered candidate predictors for modeling of RP grade≥3. A baseline logistic regression model with mean lung dose (MLD) was first considered. Additionally, a least absolute shrinkage and selection operator (LASSO) logistic regression was applied to the set of clinical and dosimetric features, and subsequently to the full set of clinical, dosimetric, and image features. Model performance was assessed by comparing area under the curve (AUC). Results: A simple logistic fit of MLD was an inadequate model of the data (AUC∼0.5). Including clinical and dosimetric parameters within the framework of the LASSO resulted in improved performance (AUC=0.648). Analysis of the full cohort of clinical, dosimetric, and image features provided further and significant improvement in model performance (AUC=0.727). Conclusions: To achieve significant gains in predictive modeling of RP, new categories of data should be considered in addition to clinical and dosimetric features. We have successfully incorporated CT image features into a framework for modeling RP and have demonstrated improved predictive performance. Validation and further investigation of CT image features in the context of RP NTCP

  11. A GMM-Based Test for Normal Disturbances of the Heckman Sample Selection Model

    Directory of Open Access Journals (Sweden)

    Michael Pfaffermayr

    2014-10-01

    Full Text Available The Heckman sample selection model relies on the assumption of normal and homoskedastic disturbances. However, before considering more general, alternative semiparametric models that do not need the normality assumption, it seems useful to test this assumption. Following Meijer and Wansbeek (2007, the present contribution derives a GMM-based pseudo-score LM test on whether the third and fourth moments of the disturbances of the outcome equation of the Heckman model conform to those implied by the truncated normal distribution. The test is easy to calculate and in Monte Carlo simulations it shows good performance for sample sizes of 1000 or larger.

  12. Including hydrological self-regulating processes in peatland models: Effects on peatmoss drought projections.

    Science.gov (United States)

    Nijp, Jelmer J; Metselaar, Klaas; Limpens, Juul; Teutschbein, Claudia; Peichl, Matthias; Nilsson, Mats B; Berendse, Frank; van der Zee, Sjoerd E A T M

    2017-02-15

    The water content of the topsoil is one of the key factors controlling biogeochemical processes, greenhouse gas emissions and biosphere - atmosphere interactions in many ecosystems, particularly in northern peatlands. In these wetland ecosystems, the water content of the photosynthetic active peatmoss layer is crucial for ecosystem functioning and carbon sequestration, and is sensitive to future shifts in rainfall and drought characteristics. Current peatland models differ in the degree in which hydrological feedbacks are included, but how this affects peatmoss drought projections is unknown. The aim of this paper was to systematically test whether the level of hydrological detail in models could bias projections of water content and drought stress for peatmoss in northern peatlands using downscaled projections for rainfall and potential evapotranspiration in the current (1991-2020) and future climate (2061-2090). We considered four model variants that either include or exclude moss (rain)water storage and peat volume change, as these are two central processes in the hydrological self-regulation of peatmoss carpets. Model performance was validated using field data of a peatland in northern Sweden. Including moss water storage as well as peat volume change resulted in a significant improvement of model performance, despite the extra parameters added. The best performance was achieved if both processes were included. Including moss water storage and peat volume change consistently reduced projected peatmoss drought frequency with >50%, relative to the model excluding both processes. Projected peatmoss drought frequency in the growing season was 17% smaller under future climate than current climate, but was unaffected by including the hydrological self-regulating processes. Our results suggest that ignoring these two fine-scale processes important in hydrological self-regulation of northern peatlands will have large consequences for projected climate change impact on

  13. Modeling an elastic beam with piezoelectric patches by including magnetic effects

    CERN Document Server

    Ozer, A O

    2014-01-01

    Models for piezoelectric beams using Euler-Bernoulli small displacement theory predict the dynamics of slender beams at the low frequency accurately but are insufficient for beams vibrating at high frequencies or beams with low length-to-width aspect ratios. A more thorough model that includes the effects of rotational inertia and shear strain, Mindlin-Timoshenko small displacement theory, is needed to predict the dynamics more accurately for these cases. Moreover, existing models ignore the magnetic effects since the magnetic effects are relatively small. However, it was shown recently \\cite{O-M1} that these effects can substantially change the controllability and stabilizability properties of even a single piezoelectric beam. In this paper, we use a variational approach to derive models that include magnetic effects for an elastic beam with two piezoelectric patches actuated by different voltage sources. Both Euler-Bernoulli and Mindlin-Timoshenko small displacement theories are considered. Due to the magne...

  14. Stability analysis of the extended ADI-FDTD technique including lumped models

    Institute of Scientific and Technical Information of China (English)

    CHEN ZhiHui; CHU QingXin

    2008-01-01

    The numerical stability of the extended alternating-direction-implicit-finite-difference-time-domain (ADI-FDTD) method including lumped models is analyzed.Three common lumped models are investigated:resistor,capacitor,and inductor,and three different formulations for each model are analyzed:the explicit,semi-implicit and implicit schemes.Analysis results show that the extended ADI-FDTD algorithm is not unconditionally stable in the explicit scheme case,and the stability criterion depends on the value of lumped models,but in the semi-implicit and implicit cases,the algorithm is stable.Finally,two simple microstrip circuits including lumped elements are simulated to demonstrate validity of the theoretical results.

  15. The Dynamic Modeling of Multiple Pairs of Spur Gears in Mesh, Including Friction and Geometrical Errors

    Directory of Open Access Journals (Sweden)

    Shengxiang Jia

    2003-01-01

    Full Text Available This article presents a dynamic model of three shafts and two pair of gears in mesh, with 26 degrees of freedom, including the effects of variable tooth stiffness, pitch and profile errors, friction, and a localized tooth crack on one of the gears. The article also details howgeometrical errors in teeth can be included in a model. The model incorporates the effects of variations in torsional mesh stiffness in gear teeth by using a common formula to describe stiffness that occurs as the gears mesh together. The comparison between the presence and absence of geometrical errors in teeth was made by using Matlab and Simulink models, which were developed from the equations of motion. The effects of pitch and profile errors on the resultant input pinion angular velocity coherent-signal of the input pinion's average are discussed by investigating some of the common diagnostic functions and changes to the frequency spectra results.

  16. SAMI2-PE: A model of the ionosphere including multistream interhemispheric photoelectron transport

    Science.gov (United States)

    Varney, R. H.; Swartz, W. E.; Hysell, D. L.; Huba, J. D.

    2012-06-01

    In order to improve model comparisons with recently improved incoherent scatter radar measurements at the Jicamarca Radio Observatory we have added photoelectron transport and energy redistribution to the two dimensional SAMI2 ionospheric model. The photoelectron model uses multiple pitch angle bins, includes effects associated with curved magnetic field lines, and uses an energy degradation procedure which conserves energy on coarse, non-uniformly spaced energy grids. The photoelectron model generates secondary electron production rates and thermal electron heating rates which are then passed to the fluid equations in SAMI2. We then compare electron and ion temperatures and electron densities of this modified SAMI2 model with measurements of these parameters over a range of altitudes from 90 km to 1650 km (L = 1.26) over a 24 hour period. The new electron heating model is a significant improvement over the semi-empirical model used in SAMI2. The electron temperatures above the F-peak from the modified model qualitatively reproduce the shape of the measurements as functions of time and altitude and quantitatively agree with the measurements to within ˜30% or better during the entire day, including during the rapid temperature increase at dawn.

  17. General spherical anisotropic Jeans models of stellar kinematics: including proper motions and radial velocities

    CERN Document Server

    Cappellari, Michele

    2015-01-01

    Cappellari (2008) presented a flexible and efficient method to model the stellar kinematics of anisotropic axisymmetric and spherical stellar systems. The spherical formalism could be used to model the line-of-sight velocity second moments allowing for essentially arbitrary radial variation in the anisotropy and general luminous and total density profiles. Here we generalize the spherical formalism by providing the expressions for all three components of the projected second moments, including the two proper motion components. A reference implementation is now included in the public JAM package available at http://purl.org/cappellari/software

  18. Modeling Within-Host Dynamics of Influenza Virus Infection Including Immune Responses

    OpenAIRE

    Pawelek, Kasia A.; Huynh, Giao T; Michelle Quinlivan; Ann Cullinane; Libin Rong; Perelson, Alan S.

    2012-01-01

    Influenza virus infection remains a public health problem worldwide. The mechanisms underlying viral control during an uncomplicated influenza virus infection are not fully understood. Here, we developed a mathematical model including both innate and adaptive immune responses to study the within-host dynamics of equine influenza virus infection in horses. By comparing modeling predictions with both interferon and viral kinetic data, we examined the relative roles of target cell availability, ...

  19. A lumped element transformer model including core losses and winding impedances

    OpenAIRE

    Ribbenfjärd, David

    2007-01-01

    In order to design a power transformer it is important to understand its internal electromagnetic behaviour. That can be obtained by measurements on physical transformers, analytical expressions and computer simulations. One benefit with simulations is that the transformer can be studied before it is built physically and that the consequences of changing dimensions and parameters easily can be tested. In this thesis a time-domain transformer model is presented. The model includes core losses ...

  20. Target echo strength modelling at FOI, including results from the BeTSSi II workshop

    CERN Document Server

    Östberg, Martin

    2016-01-01

    An overview of the target echo strength (TS) modelling capacity at the Swedish Defense Research Agency (FOI) is presented. The modelling methods described range from approximate ones, such as raytracing and Kirchhoff approximation codes, to high accuracy full field codes including boundary integral equation methods and finite elements methods. Illustrations of the applicability of the codes are given for a few simple cases tackled during the BeTTSi II (Benchmark Target Echo Strength Simulation) workshop held in Kiel 2014.

  1. Including leakage in network models: an application to calibrate leak valves in EPANET

    OpenAIRE

    Cobacho Jordán, Ricardo; Arregui de la Cruz, Francisco; Soriano Olivares, Javier; Cabrera Rochera, Enrique

    2015-01-01

    EPANET is one of the most widely used software packages for water network hydraulic modelling, and is especially interesting for educational and research purposes because it is in the public domain. However, EPANET simulations are demand-driven, and the program does not include a specific functionality to model water leakage, which is pressure-driven. Consequently, users are required to deal with this drawback by themselves. As a general solution for this problem, this paper presents a method...

  2. Key Characteristics of Combined Accident including TLOFW accident for PSA Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bo Gyung; Kang, Hyun Gook [KAIST, Daejeon (Korea, Republic of); Yoon, Ho Joon [Khalifa University of Science, Technology and Research, Abu Dhabi (United Arab Emirates)

    2015-05-15

    The conventional PSA techniques cannot adequately evaluate all events. The conventional PSA models usually focus on single internal events such as DBAs, the external hazards such as fire, seismic. However, the Fukushima accident of Japan in 2011 reveals that very rare event is necessary to be considered in the PSA model to prevent the radioactive release to environment caused by poor treatment based on lack of the information, and to improve the emergency operation procedure. Especially, the results from PSA can be used to decision making for regulators. Moreover, designers can consider the weakness of plant safety based on the quantified results and understand accident sequence based on human actions and system availability. This study is for PSA modeling of combined accidents including total loss of feedwater (TLOFW) accident. The TLOFW accident is a representative accident involving the failure of cooling through secondary side. If the amount of heat transfer is not enough due to the failure of secondary side, the heat will be accumulated to the primary side by continuous core decay heat. Transients with loss of feedwater include total loss of feedwater accident, loss of condenser vacuum accident, and closure of all MSIVs. When residual heat removal by the secondary side is terminated, the safety injection into the RCS with direct primary depressurization would provide alternative heat removal. This operation is called feed and bleed (F and B) operation. Combined accidents including TLOFW accident are very rare event and partially considered in conventional PSA model. Since the necessity of F and B operation is related to plant conditions, the PSA modeling for combined accidents including TLOFW accident is necessary to identify the design and operational vulnerabilities.The PSA is significant to assess the risk of NPPs, and to identify the design and operational vulnerabilities. Even though the combined accident is very rare event, the consequence of combined

  3. 76 FR 81360 - Special Conditions: Gulfstream Aerospace LP (GALP) Model G280 Airplane, Operation Without Normal...

    Science.gov (United States)

    2011-12-28

    ... G280 Airplane, Operation Without Normal Electrical Power AGENCY: Federal Aviation Administration (FAA... associated with operation without normal electrical power. The applicable airworthiness regulations do not... Model G280 will have a novel or unusual design feature associated with operation without...

  4. 76 FR 8314 - Special Conditions: Gulfstream Model GVI Airplane; Operation Without Normal Electric Power

    Science.gov (United States)

    2011-02-14

    ..., 2006. The Gulfstream Model GVI airplane will be an all-new, two- engine jet transport airplane with an... traditional designs, the GVI must be designed for operation with the normal sources of engine and auxiliary...; Operation Without Normal Electric Power AGENCY: Federal Aviation Administration (FAA), DOT. ACTION:...

  5. Analysis of a generalized model for influenza including differential susceptibility due to immunosuppression

    Science.gov (United States)

    Hincapié, Doracelly; Ospina, Juan

    2014-06-01

    Recently, a mathematical model of pandemic influenza was proposed including typical control strategies such as antivirals, vaccination and school closure; and considering explicitly the effects of immunity acquired from the early outbreaks on the ulterior outbreaks of the disease. In such model the algebraic expression for the basic reproduction number (without control strategies) and the effective reproduction number (with control strategies) were derived and numerically estimated. A drawback of this model of pandemic influenza is that it ignores the effects of the differential susceptibility due to immunosuppression and the effects of the complexity of the actual contact networks between individuals. We have developed a generalized model which includes such effects of heterogeneity. Specifically we consider the influence of the air network connectivity in the spread of pandemic influenza and the influence of the immunosuppresion when the population is divided in two immune classes. We use an algebraic expression, namely the Tutte polynomial, to characterize the complexity of the contact network. Until now, The influence of the air network connectivity in the spread of pandemic influenza has been studied numerically, but not algebraic expressions have been used to summarize the level of network complexity. The generalized model proposed here includes the typical control strategies previously mentioned (antivirals, vaccination and school closure) combined with restrictions on travel. For the generalized model the corresponding reproduction numbers will be algebraically computed and the effect of the contact network will be established in terms of the Tutte polynomial of the network.

  6. The No-Core Gamow Shell Model: Including the continuum in the NCSM

    CERN Document Server

    Barrett, B R; Michel, N; Płoszajczak, M

    2015-01-01

    We are witnessing an era of intense experimental efforts that will provide information about the properties of nuclei far from the line of stability, regarding resonant and scattering states as well as (weakly) bound states. This talk describes our formalism for including these necessary ingredients into the No-Core Shell Model by using the Gamow Shell Model approach. Applications of this new approach, known as the No-Core Gamow Shell Model, both to benchmark cases as well as to unstable nuclei will be given.

  7. The Watts-Strogatz network model developed by including degree distribution: theory and computer simulation

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Y W [Surface Physics Laboratory and Department of Physics, Fudan University, Shanghai 200433 (China); Zhang, L F [Surface Physics Laboratory and Department of Physics, Fudan University, Shanghai 200433 (China); Huang, J P [Surface Physics Laboratory and Department of Physics, Fudan University, Shanghai 200433 (China)

    2007-07-20

    By using theoretical analysis and computer simulations, we develop the Watts-Strogatz network model by including degree distribution, in an attempt to improve the comparison between characteristic path lengths and clustering coefficients predicted by the original Watts-Strogatz network model and those of the real networks with the small-world property. Good agreement between the predictions of the theoretical analysis and those of the computer simulations has been shown. It is found that the developed Watts-Strogatz network model can fit the real small-world networks more satisfactorily. Some other interesting results are also reported by adjusting the parameters in a model degree-distribution function. The developed Watts-Strogatz network model is expected to help in the future analysis of various social problems as well as financial markets with the small-world property.

  8. Dynamics Analysis of an HIV Infection Model including Infected Cells in an Eclipse Stage

    Directory of Open Access Journals (Sweden)

    Shengyu Zhou

    2013-01-01

    Full Text Available In this paper, an HIV infection model including an eclipse stage of infected cells is considered. Some quicker cells in this stage become productively infected cells, a portion of these cells are reverted to the uninfected class, and others will be latent down in the body. We consider CTL-response delay in this model and analyze the effect of time delay on stability of equilibrium. It is shown that the uninfected equilibrium and CTL-absent infection equilibrium are globally asymptotically stable for both ODE and DDE model. And we get the global stability of the CTL-present equilibrium for ODE model. For DDE model, we have proved that the CTL-present equilibrium is locally asymptotically stable in a range of delays and also have studied the existence of Hopf bifurcations at the CTL-present equilibrium. Numerical simulations are carried out to support our main results.

  9. Modeling of the dynamics of wind to power conversion including high wind speed behavior

    DEFF Research Database (Denmark)

    Litong-Palima, Marisciel; Bjerge, Martin Huus; Cutululis, Nicolaos Antonio

    2016-01-01

    of power system studies, but the idea of the proposed wind turbine model is to include the main dynamic effects in order to have a better representation of the fluctuations in the output power and of the fast power ramping especially because of high wind speed shutdowns of the wind turbine. The high wind......This paper proposes and validates an efficient, generic and computationally simple dynamic model for the conversion of the wind speed at hub height into the electrical power by a wind turbine. This proposed wind turbine model was developed as a first step to simulate wind power time series...... for power system studies. This paper focuses on describing and validating the single wind turbine model, and is therefore neither describing wind speed modeling nor aggregation of contributions from a whole wind farm or a power system area. The state-of-the-art is to use static power curves for the purpose...

  10. Non-insect crustacean models in developmental genetics including an encomium to Parhyale hawaiensis.

    Science.gov (United States)

    Stamataki, Evangelia; Pavlopoulos, Anastasios

    2016-08-01

    The impressive diversity of body plans, lifestyles and segmental specializations exhibited by crustaceans (barnacles, copepods, shrimps, crabs, lobsters and their kin) provides great material to address longstanding questions in evolutionary developmental biology. Recent advances in forward and reverse genetics and in imaging approaches applied in the amphipod Parhyale hawaiensis and other emerging crustacean model species have made it possible to probe the molecular and cellular basis of crustacean diversity. A number of biological and technical qualities like the slow tempo and holoblastic cleavage mode, the stereotypy of many cellular processes, the functional and morphological diversity of limbs along the body axis, and the availability of various experimental manipulations, have made Parhyale a powerful system to study normal development and regeneration. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. A statistical model including age to predict passenger postures in the rear seats of automobiles.

    Science.gov (United States)

    Park, Jangwoon; Ebert, Sheila M; Reed, Matthew P; Hallman, Jason J

    2016-06-01

    Few statistical models of rear seat passenger posture have been published, and none has taken into account the effects of occupant age. This study developed new statistical models for predicting passenger postures in the rear seats of automobiles. Postures of 89 adults with a wide range of age and body size were measured in a laboratory mock-up in seven seat configurations. Posture-prediction models for female and male passengers were separately developed by stepwise regression using age, body dimensions, seat configurations and two-way interactions as potential predictors. Passenger posture was significantly associated with age and the effects of other two-way interaction variables depended on age. A set of posture-prediction models are presented for women and men, and the prediction results are compared with previously published models. This study is the first study of passenger posture to include a large cohort of older passengers and the first to report a significant effect of age for adults. The presented models can be used to position computational and physical human models for vehicle design and assessment. Practitioner Summary: The significant effects of age, body dimensions and seat configuration on rear seat passenger posture were identified. The models can be used to accurately position computational human models or crash test dummies for older passengers in known rear seat configurations.

  12. ASYMPTOTIC NORMALITY OF PARAMETERS ESTIMATION IN EV MODEL WITH REPLICATED OBSERVATIONS

    Institute of Scientific and Technical Information of China (English)

    张三国; 陈希孺

    2002-01-01

    This paper based on the essay [1], studies in case that replicated observations are available in some experimental points, the parameters estimation of one dimensional linear errors-in-variables (EV) models. Asymptotic normality is established.

  13. Non steroidal antiinflammatory drugs may be harmful to normal kidneys: experimental surgery model*

    OpenAIRE

    Hur, E; E. Duman; Bozkurt, D; Sozmen, E; Sen, S; Taskin, H; Timur, O; Kaya, SO; Duman, S

    2012-01-01

    Background and aim: The exact effect of analgesics on normal kidneys is not known yet. We aimed to evaluate the impression of non steroidal antiinflammatory drugs (NSAID) used post-operatively on kidneys, in rat (tracheotomy) model.

  14. Currents, HF Radio-derived, Ano Nuevo, Normal Model, Zonal, EXPERIMENTAL

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data is the zonal component of ocean surface currents derived from High Frequency Radio-derived measurements, with missing values filled in by a normal model....

  15. Currents, HF Radio-derived, SF Bay Outlet, Normal Model, Zonal, EXPERIMENTAL

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data is the zonal component of ocean surface currents derived from High Frequency Radio-derived measurements, with missing values filled in by a normal model....

  16. Impact of statistical learning methods on the predictive power of multivariate normal tissue complication probability models

    NARCIS (Netherlands)

    Xu, Cheng-Jian; van der Schaaf, Arjen; Schilstra, Cornelis; Langendijk, Johannes A.; van t Veld, Aart A.

    2012-01-01

    PURPOSE: To study the impact of different statistical learning methods on the prediction performance of multivariate normal tissue complication probability (NTCP) models. METHODS AND MATERIALS: In this study, three learning methods, stepwise selection, least absolute shrinkage and selection operator

  17. Currents, HF Radio-derived, Monterey Bay, Normal Model, Zonal, EXPERIMENTAL

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data is the zonal component of ocean surface currents derived from High Frequency Radio-derived measurements, with missing values filled in by a normal model....

  18. Expression patterns of DLK1 and INSL3 identify stages of Leydig cell differentiation during normal development and in testicular pathologies, including testicular cancer and Klinefelter syndrome

    DEFF Research Database (Denmark)

    Lottrup, G; Nielsen, J E; Maroun, L L

    2014-01-01

    STUDY QUESTION: What is the differentiation stage of human testicular interstitial cells, in particular Leydig cells (LC), within micronodules found in patients with infertility, testicular cancer and Klinefelter syndrome? SUMMARY ANSWER: The Leydig- and peritubular-cell populations in testes....... MAIN RESULTS AND THE ROLE OF CHANCE: DLK1, INSL3 and COUP-TFII expression changed during normal development and was linked to different stages of LC differentiation: DLK1 was expressed in all fetal LCs, but only in spindle-shaped progenitor cells and in a small subset of polygonal LCs in the normal....... WIDER IMPLICATIONS OF THE FINDINGS: The population of LCs, especially those clustered in large nodules, are heterogeneous and comprise cells at different stages of differentiation. The study demonstrated that the differentiation and function of LCs, and possibly also peritubular cells, are impaired...

  19. Developing parameters for multi-mode ambient air models including the nanometer mode

    Science.gov (United States)

    Tronville, Paolo; Rivers, Richard

    2017-06-01

    The particle count, surface and mass in an occupied space can be modeled when the HVAC system airflows are known, along with the particle-size distribution for outdoor air, internal generation rates as a function of particle size, and the efficiency as a function of particle size for filters present. Outdoor air particle-size distribution is rarely available, but measures of particle mass concentration, PM2.5 and PM10, are often available for building locations. Outdoor air aerosol size distributions are well modeled by sums of two or three log-normal distributions, with essentially all mass in two larger modes. Studies have also shown that some mode parameters are, in general, related by simple functions. This paper shows how these relationships can be combined with known characteristics of PM2.5 and PM10 samplers to create reasonable inclusive models of outdoor air aerosol-size distributions. This information plus knowledge of indoor particle generation allows calculation of aerosol mass in occupied spaces. Estimation of parameters of aerosol modes with sizes below100 nm and measurement of filter efficiencies in that range are described.

  20. Fusion rules for the logarithmic $N=1$ superconformal minimal models II: including the Ramond sector

    CERN Document Server

    Canagasabey, Michael

    2015-01-01

    The Virasoro logarithmic minimal models were intensively studied by several groups over the last ten years with much attention paid to the fusion rules and the structures of the indecomposable representations that fusion generates. The analogous study of the fusion rules of the $N=1$ superconformal logarithmic minimal models was initiated in arXiv:1504.03155 as a continuum counterpart to the lattice explorations of arXiv:1312.6763. These works restricted fusion considerations to Neveu-Schwarz representations. Here, this is extended to include the Ramond sector. Technical advances that make this possible include a fermionic Verlinde formula applicable to logarithmic conformal field theories and a twisted version of the fusion algorithm of Nahm and Gaberdiel-Kausch. The results include the first construction and detailed analysis of logarithmic structures in the Ramond sector.

  1. MEMLS3&a: Microwave Emission Model of Layered Snowpacks adapted to include backscattering

    Directory of Open Access Journals (Sweden)

    M. Proksch

    2015-08-01

    Full Text Available The Microwave Emission Model of Layered Snowpacks (MEMLS was originally developed for microwave emissions of snowpacks in the frequency range 5–100 GHz. It is based on six-flux theory to describe radiative transfer in snow including absorption, multiple volume scattering, radiation trapping due to internal reflection and a combination of coherent and incoherent superposition of reflections between horizontal layer interfaces. Here we introduce MEMLS3&a, an extension of MEMLS, which includes a backscatter model for active microwave remote sensing of snow. The reflectivity is decomposed into diffuse and specular components. Slight undulations of the snow surface are taken into account. The treatment of like- and cross-polarization is accomplished by an empirical splitting parameter q. MEMLS3&a (as well as MEMLS is set up in a way that snow input parameters can be derived by objective measurement methods which avoid fitting procedures of the scattering efficiency of snow, required by several other models. For the validation of the model we have used a combination of active and passive measurements from the NoSREx (Nordic Snow Radar Experiment campaign in Sodankylä, Finland. We find a reasonable agreement between the measurements and simulations, subject to uncertainties in hitherto unmeasured input parameters of the backscatter model. The model is written in Matlab and the code is publicly available for download through the following website: http://www.iapmw.unibe.ch/research/projects/snowtools/memls.html.

  2. MEMLS3&a: Microwave Emission Model of Layered Snowpacks adapted to include backscattering

    Directory of Open Access Journals (Sweden)

    M. Proksch

    2015-03-01

    Full Text Available The Microwave Emission Model of Layered Snowpacks (MEMLS was originally developed for microwave emissions of snowpacks in the frequency range 5–100 GHz. It is based on six-flux theory to describe radiative transfer in snow including absorption, multiple volume scattering, radiation trapping due to internal reflection and a combination of coherent and incoherent superposition of reflections between horizontal layer interfaces. Here we introduce MEMLS3&a, an extension of MEMLS, which includes a backscatter model for active microwave remote sensing of snow. The reflectivity is decomposed into diffuse and specular components. Slight undulations of the snow surface are taken into account. The treatment of like and cross polarization is accomplished by an empirical splitting parameter q. MEMLS3&a (as well as MEMLS is set up in a way that snow input parameters can be derived by objective measurement methods which avoids fitting procedures of the scattering efficiency of snow, required by several other models. For the validation of the model we have used a combination of active and passive measurements from the NoSREx campaign in Sodankylä, Finland. We find a reasonable agreement between the measurements and simulations, subject to uncertainties in hitherto unmeasured input parameters of the backscatter model. The model is written in MATLAB and the code is publicly available for download through the following website: http://www.iapmw.unibe.ch/research/projects/snowtools/memls.html.

  3. MEMLS3&a: Microwave Emission Model of Layered Snowpacks adapted to include backscattering

    Science.gov (United States)

    Proksch, M.; Mätzler, C.; Wiesmann, A.; Lemmetyinen, J.; Schwank, M.; Löwe, H.; Schneebeli, M.

    2015-08-01

    The Microwave Emission Model of Layered Snowpacks (MEMLS) was originally developed for microwave emissions of snowpacks in the frequency range 5-100 GHz. It is based on six-flux theory to describe radiative transfer in snow including absorption, multiple volume scattering, radiation trapping due to internal reflection and a combination of coherent and incoherent superposition of reflections between horizontal layer interfaces. Here we introduce MEMLS3&a, an extension of MEMLS, which includes a backscatter model for active microwave remote sensing of snow. The reflectivity is decomposed into diffuse and specular components. Slight undulations of the snow surface are taken into account. The treatment of like- and cross-polarization is accomplished by an empirical splitting parameter q. MEMLS3&a (as well as MEMLS) is set up in a way that snow input parameters can be derived by objective measurement methods which avoid fitting procedures of the scattering efficiency of snow, required by several other models. For the validation of the model we have used a combination of active and passive measurements from the NoSREx (Nordic Snow Radar Experiment) campaign in Sodankylä, Finland. We find a reasonable agreement between the measurements and simulations, subject to uncertainties in hitherto unmeasured input parameters of the backscatter model. The model is written in Matlab and the code is publicly available for download through the following website: http://www.iapmw.unibe.ch/research/projects/snowtools/memls.html.

  4. Diagnosing Lee Wave Rotor Onset Using a Linear Model Including a Boundary Layer

    Directory of Open Access Journals (Sweden)

    Miguel A. C. Teixeira

    2017-01-01

    Full Text Available A linear model is used to diagnose the onset of rotors in flow over 2D hills, for atmospheres that are neutrally stratified near the surface and stably stratified aloft, with a sharp temperature inversion in between, where trapped lee waves may propagate. This is achieved by coupling an inviscid two-layer mountain-wave model and a bulk boundary-layer model. The full model shows some ability to diagnose flow stagnation associated with rotors as a function of key input parameters, such as the Froude number and the height of the inversion, in numerical simulations and laboratory experiments carried out by previous authors. While calculations including only the effects of mean flow attenuation and velocity perturbation amplification within the surface layer represent flow stagnation fairly well in the more non-hydrostatic cases, only the full model, taking into account the feedback of the surface layer on the inviscid flow, satisfactorily predicts flow stagnation in the most hydrostatic case, although the corresponding condition is unable to discriminate between rotors and hydraulic jumps. Versions of the model not including this feedback severely underestimate the amplitude of trapped lee waves in that case, where the Fourier transform of the hill has zeros, showing that those waves are not forced directly by the orography.

  5. Strained and unconstrained multivariate normal finite mixture modeling of Piagetian data.

    NARCIS (Netherlands)

    Dolan, C.V.; Jansen, B.R.J.; van der Maas, H.L.J.

    2004-01-01

    We present the results of multivariate normal mixture modeling of Piagetian data. The sample consists of 101 children, who carried out a (pseudo-)conservation computer task on four occasions. We fitted both cross-sectional mixture models, and longitudinal models based on a Markovian transition

  6. Latest cosmological constraints on Cardassian expansion models including the updated gamma-ray bursts

    Institute of Scientific and Technical Information of China (English)

    Nan Liang; Pu-Xun Wua; Zong-Hong Zhu

    2011-01-01

    We constrain the Cardassian expansion models from the latest observations,including the updated Gamma-ray bursts (GRBs),which are calibrated using a cosmology independent method from the Union2 compilation of type Ia supernovae (SNe Ia).By combining the GRB data with the joint observations from the Union2SNe Ia set,along with the results from the Cosmic Microwave Background radiation observation from the seven-year Wilkinson Microwave Anisotropy Probe and the baryonic acoustic oscillation observation galaxy sample from the spectroscopic Sloan Digital Sky Survey Data Release,we find significant constraints on the model parameters of the original Cardassian model ΩM0=n 282+0.015-0.014,n=0.03+0.05-0.05;and n = -0.16+0.25-3.26,β=-0.76+0.34-0.58 of the modified polytropic Cardassian model,which are consistent with the ACDM model in a l-σ confidence region.From the reconstruction of the deceleration parameter q(z) in Cardassian models,we obtain the transition redshift ZT = 0.73 ± 0.04 for the original Cardassian model and ZT = 0.68 ± 0.04 for the modified polytropic Cardassian model.

  7. Safe distance car-following model including backward-looking and its stability analysis

    Science.gov (United States)

    Yang, Da; Jin, Peter Jing; Pu, Yun; Ran, Bin

    2013-03-01

    The focus of this paper is the car-following behavior including backward-looking, simply called the bi-directional looking car-following behavior. This study is motivated by the potential changes of the physical properties of traffic flow caused by the fast developing intelligent transportation system (ITS), especially the new connected vehicle technology. Existing studies on this topic focused on general motors (GM) models and optimal velocity (OV) models. The safe distance car-following model, Gipps' model, which is more widely used in practice have not drawn too much attention in the bi-directional looking context. This paper explores the property of the bi-directional looking extension of Gipps' safe distance model. The stability condition of the proposed model is derived using the linear stability theory and is verified using numerical simulations. The impacts of the driver and vehicle characteristics appeared in the proposed model on the traffic flow stability are also investigated. It is found that taking into account the backward-looking effect in car-following has three types of effect on traffic flow: stabilizing, destabilizing and producing non-physical phenomenon. This conclusion is more sophisticated than the study results based on the OV bi-directional looking car-following models. Moreover, the drivers who have the smaller reaction time or the larger additional delay and think the other vehicles have larger maximum decelerations can stabilize traffic flow.

  8. Viscous flow features in scaled-up physical models of normal and pathological vocal phonation

    Energy Technology Data Exchange (ETDEWEB)

    Erath, Byron D., E-mail: berath@purdue.ed [School of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, IN 47907 (United States); Plesniak, Michael W., E-mail: plesniak@gwu.ed [Department of Mechanical and Aerospace Engineering, George Washington University, 801 22nd Street NW, Suite 739, Washington, DC 20052 (United States)

    2010-06-15

    Unilateral vocal fold paralysis results when the recurrent laryngeal nerve, which innervates the muscles of the vocal folds becomes damaged. The loss of muscle and tension control to the damaged vocal fold renders it ineffectual. The mucosal wave disappears during phonation, and the vocal fold becomes largely immobile. The influence of unilateral vocal fold paralysis on the viscous flow development, which impacts speech quality within the glottis during phonation was investigated. Driven, scaled-up vocal fold models were employed to replicate both normal and pathological patterns of vocal fold motion. Spatial and temporal velocity fields were captured using particle image velocimetry, and laser Doppler velocimetry. Flow parameters were scaled to match the physiological values associated with human speech. Loss of motion in one vocal fold resulted in a suppression of typical glottal flow fields, including decreased spatial variability in the location of the flow separation point throughout the phonatory cycle, as well as a decrease in the vorticity magnitude.

  9. A Lumped Thermal Model Including Thermal Coupling and Thermal Boundary Conditions for High Power IGBT Modules

    DEFF Research Database (Denmark)

    Bahman, Amir Sajjad; Ma, Ke; Blaabjerg, Frede

    2017-01-01

    Detailed thermal dynamics of high power IGBT modules are important information for the reliability analysis and thermal design of power electronic systems. However, the existing thermal models have their limits to correctly predict these complicated thermal behavior in the IGBTs: The typically used...... thermal distribution under long-term studies. Meanwhile the boundary conditions for the thermal analysis are modeled and included, which can be adapted to different real field applications of power electronic converters. Finally, the accuracy of the proposed thermal model is verified by FEM simulations...... thermal model based on one-dimensional RC lumps have limits to provide temperature distributions inside the device, moreover some variable factors in the real-field applications like the cooling and heating conditions of the converter cannot be adapted. On the other hand, the more advanced three...

  10. A Lumped Thermal Model Including Thermal Coupling and Thermal Boundary Conditions for High Power IGBT Modules

    DEFF Research Database (Denmark)

    Bahman, Amir Sajjad; Ma, Ke; Blaabjerg, Frede

    2017-01-01

    Detailed thermal dynamics of high power IGBT modules are important information for the reliability analysis and thermal design of power electronic systems. However, the existing thermal models have their limits to correctly predict these complicated thermal behavior in the IGBTs: The typically used...... thermal distribution under long-term studies. Meanwhile the boundary conditions for the thermal analysis are modeled and included, which can be adapted to different real-field applications of power electronic converters. Finally, the accuracy of the proposed thermal model is verified by FEM simulations...... thermal model based on one-dimensional RC lumps have limits to provide temperature distributions inside the device, moreover some variable factors in the real-field applications like the cooling and heating conditions of the converter cannot be adapted. On the other hand, the more advanced three...

  11. Modelling of real area of contact between tool and workpiece in metal forming processes including the influence of subsurface deformation

    DEFF Research Database (Denmark)

    Nielsen, Chris Valentin; Martins, Paulo A. F.; Bay, Niels Oluf

    2016-01-01

    New equipment for testing asperity deformation at various normal loads and subsurface elongations is presented. Resulting real contact area ratios increase heavily with increasing subsurface expansion due to lowered yield pressure on the asperities when imposing subsurface normal stress parallel ...... for estimating friction in the numerical modelling of metal forming processes....

  12. Transmission line model for strained quantum well lasers including carrier transport and carrier heating effects.

    Science.gov (United States)

    Xia, Mingjun; Ghafouri-Shiraz, H

    2016-03-01

    This paper reports a new model for strained quantum well lasers, which are based on the quantum well transmission line modeling method where effects of both carrier transport and carrier heating have been included. We have applied this new model and studied the effect of carrier transport on the output waveform of a strained quantum well laser both in time and frequency domains. It has been found that the carrier transport increases the turn-on, turn-off delay times and damping of the quantum well laser transient response. Also, analysis in the frequency domain indicates that the carrier transport causes the output spectrum of the quantum well laser in steady state to exhibit a redshift which has a narrower bandwidth and lower magnitude. The simulation results of turning-on transients obtained by the proposed model are compared with those obtained by the rate equation laser model. The new model has also been used to study the effects of pump current spikes on the laser output waveforms properties, and it was found that the presence of current spikes causes (i) wavelength blueshift, (ii) larger bandwidth, and (iii) reduces the magnitude and decreases the side-lobe suppression ratio of the laser output spectrum. Analysis in both frequency and time domains confirms that the new proposed model can accurately predict the temporal and spectral behaviors of strained quantum well lasers.

  13. A numerical model including PID control of a multizone crystal growth furnace

    Science.gov (United States)

    Panzarella, Charles H.; Kassemi, Mohammad

    This paper presents a 2D axisymmetric combined conduction and radiation model of a multizone crystal growth furnace. The model is based on a programmable multizone furnace (PMZF) designed and built at NASA Lewis Research Center for growing high quality semiconductor crystals. A novel feature of this model is a control algorithm which automatically adjusts the power in any number of independently controlled heaters to establish the desired crystal temperatures in the furnace model. The control algorithm eliminates the need for numerous trial and error runs previously required to obtain the same results. The finite element code, FIDAP, used to develop the furnace model, was modified to directly incorporate the control algorithm. This algorithm, which presently uses PID control, and the associated heat transfer model are briefly discussed. Together, they have been used to predict the heater power distributions for a variety of furnace configurations and desired temperature profiles. Examples are included to demonstrate the effectiveness of the PID controlled model in establishing isothermal, Bridgman, and other complicated temperature profies in the sample. Finally, an example is given to show how the algorithm can be used to change the desired profile with time according to a prescribed temperature-time evolution.

  14. A continuum model of solvation energies including electrostatic, dispersion, and cavity contributions.

    Science.gov (United States)

    Duignan, Timothy T; Parsons, Drew F; Ninham, Barry W

    2013-08-15

    Physically accurate continuum solvent models that can calculate solvation energies are crucial to explain and predict the behavior of solute particles in water. Here, we present such a model applied to small spherical ions and neutral atoms. It improves upon a basic Born electrostatic model by including a standard cavity energy and adding a dispersion component, consistent with the Born electrostatic energy and using the same cavity size parameter. We show that the well-known, puzzling differences between the solvation energies of ions of the same size is attributable to the neglected dispersion contribution. This depends on dynamic polarizability as well as size. Generally, a large cancellation exists between the cavity and dispersion contributions. This explains the surprising success of the Born model. The model accurately reproduces the solvation energies of the alkali halide ions, as well as the silver(I) and copper(I) ions with an error of 12 kJ mol(-1) (±3%). The solvation energy of the noble gases is also reproduced with an error of 2.6 kJ mol(-1) (±30%). No arbitrary fitting parameters are needed to achieve this. This model significantly improves our understanding of ionic solvation and forms a solid basis for the investigation of other ion-specific effects using a continuum solvent model.

  15. Model for resistance evolution in shape memory alloys including R-phase

    Science.gov (United States)

    Brammajyosula, Ravindra; Buravalla, Vidyashankar; Khandelwal, Ashish

    2011-03-01

    The electrical resistance behavior of a shape memory alloy (SMA) wire can be used for sensing the state of an SMA device. Hence, this study investigates the resistance evolution in SMAs. A lumped parameter model with cosine kinetics to capture the resistance variation during the phase transformation is developed. Several SMA materials show the presence of trigonal or rhombohedral (R) phase as an intermediate phase, apart from the commonly recognized austenite and martensite phases. Most of the SMA models ignore the R-phase effect in their prediction of thermomechanical response. This may be acceptable since the changes in thermomechanical response associated with the R-phase are relatively less. However, the resistivity related effects are pronounced in the presence of the R-phase and its appearance introduces non-monotonicity in the resistivity evolution. This leads to additional complexities in the use of resistance signal for sensing and control. Hence, a lumped model is developed here for resistance evolution including the R-phase effects. A phase-diagram-based model is proposed for predicting electro-thermomechanical response. Both steady state hysteretic response and transient response are modeled. The model predictions are compared with the available test data. Numerical studies have shown that the model is able to capture all the essential features of the resistance evolution in SMAs in the presence of the R-phase.

  16. A New Circuit Model for Spin-Torque Oscillator Including Perpendicular Torque of Magnetic Tunnel Junction

    Directory of Open Access Journals (Sweden)

    Hyein Lim

    2013-01-01

    Full Text Available Spin-torque oscillator (STO is a promising new technology for the future RF oscillators, which is based on the spin-transfer torque (STT effect in magnetic multilayered nanostructure. It is expected to provide a larger tunability, smaller size, lower power consumption, and higher level of integration than the semiconductor-based oscillators. In our previous work, a circuit-level model of the giant magnetoresistance (GMR STO was proposed. In this paper, we present a physics-based circuit-level model of the magnetic tunnel junction (MTJ-based STO. MTJ-STO model includes the effect of perpendicular torque that has been ignored in the GMR-STO model. The variations of three major characteristics, generation frequency, mean oscillation power, and generation linewidth of an MTJ-STO with respect to the amount of perpendicular torque, are investigated, and the results are applied to our model. The operation of the model was verified by HSPICE simulation, and the results show an excellent agreement with the experimental data. The results also prove that a full circuit-level simulation with MJT-STO devices can be made with our proposed model.

  17. Does including physiology improve species distribution model predictions of responses to recent climate change?

    Science.gov (United States)

    Buckley, Lauren B; Waaser, Stephanie A; MacLean, Heidi J; Fox, Richard

    2011-12-01

    Thermal constraints on development are often invoked to predict insect distributions. These constraints tend to be characterized in species distribution models (SDMs) by calculating development time based on a constant lower development temperature (LDT). Here, we assessed whether species-specific estimates of LDT based on laboratory experiments can improve the ability of SDMs to predict the distribution shifts of six U.K. butterflies in response to recent climate warming. We find that species-specific and constant (5 degrees C) LDT degree-day models perform similarly at predicting distributions during the period of 1970-1982. However, when the models for the 1970-1982 period are projected to predict distributions in 1995-1999 and 2000-2004, species-specific LDT degree-day models modestly outperform constant LDT degree-day models. Our results suggest that, while including species-specific physiology in correlative models may enhance predictions of species' distribution responses to climate change, more detailed models may be needed to adequately account for interspecific physiological differences.

  18. Modeling of single char combustion, including CO oxidation in its boundary layer

    Energy Technology Data Exchange (ETDEWEB)

    Lee, C.H.; Longwell, J.P.; Sarofim, A.F.

    1994-10-25

    The combustion of a char particle can be divided into a transient phase where its temperature increases as it is heated by oxidation, and heat transfer from the surrounding gas to an approximately constant temperature stage where gas phase reaction is important and which consumes most of the carbon and an extinction stage caused by carbon burnout. In this work, separate models were developed for the transient heating where gas phase reactions were unimportant and for the steady temperature stage where gas phase reactions were treated in detail. The transient char combustion model incorporates intrinsic char surface production of CO and CO{sub 2}, internal pore diffusion and external mass and heat transfer. The model provides useful information for particle ignition, burning temperature profile, combustion time, and carbon consumption rate. A gas phase reaction model incorporating the full set of 28 elementary C/H/O reactions was developed. This model calculated the gas phase CO oxidation reaction in the boundary layer at particle temperatures of 1250 K and 2500 K by using the carbon consumption rate and the burning temperature at the pseudo-steady state calculated from the temperature profile model but the transient heating was not included. This gas phase model can predict the gas species, and the temperature distributions in the boundary layer, the CO{sub 2}/CO ratio, and the location of CO oxidation. A mechanistic heat and mass transfer model was added to the temperature profile model to predict combustion behavior in a fluidized bed. These models were applied to data from the fluidized combustion of Newlands coal char particles. 52 refs., 60 figs.

  19. Including source uncertainty and prior information in the analysis of stable isotope mixing models.

    Science.gov (United States)

    Ward, Eric J; Semmens, Brice X; Schindler, Daniel E

    2010-06-15

    Stable isotope mixing models offer a statistical framework for estimating the contribution of multiple sources (such as prey) to a mixture distribution. Recent advances in these models have estimated the source proportions using Bayesian methods, but have not explicitly accounted for uncertainty in the mean and variance of sources. We demonstrate that treating these quantities as unknown parameters can reduce bias in the estimated source contributions, although model complexity is increased (thereby increasing the variance of estimates). The advantages of this fully Bayesian approach are particularly apparent when the source geometry is poor or sample sizes are small. A second benefit to treating source quantities as parameters is that prior source information can be included. We present findings from 9 lake food-webs, where the consumer of interest (fish) has a diet composed of 5 sources: aquatic insects, snails, zooplankton, amphipods, and terrestrial insects. We compared the traditional Bayesian stable isotope mixing model with fixed source parameters to our fully Bayesian model-with and without an informative prior. The informative prior has much less impact than the choice of model-the traditional mixing model with fixed source parameters estimates the diet to be dominated by aquatic insects, while the fully Bayesian model estimates the diet to be more balanced but with greater importance of zooplankton. The findings from this example demonstrate that there can be stark differences in inference between the two model approaches, particularly when the source geometry of the mixing model is poor. These analyses also emphasize the importance of investing substantial effort toward characterizing the variation in the isotopic characteristics of source pools to appropriately quantify uncertainties in their contributions to consumers in food webs.

  20. Kinetic modeling of rhamnolipid production by Pseudomonas aeruginosa PAO1 including cell density-dependent regulation.

    Science.gov (United States)

    Henkel, Marius; Schmidberger, Anke; Vogelbacher, Markus; Kühnert, Christian; Beuker, Janina; Bernard, Thomas; Schwartz, Thomas; Syldatk, Christoph; Hausmann, Rudolf

    2014-08-01

    The production of rhamnolipid biosurfactants by Pseudomonas aeruginosa is under complex control of a quorum sensing-dependent regulatory network. Due to a lack of understanding of the kinetics applicable to the process and relevant interrelations of variables, current processes for rhamnolipid production are based on heuristic approaches. To systematically establish a knowledge-based process for rhamnolipid production, a deeper understanding of the time-course and coupling of process variables is required. By combining reaction kinetics, stoichiometry, and experimental data, a process model for rhamnolipid production with P. aeruginosa PAO1 on sunflower oil was developed as a system of coupled ordinary differential equations (ODEs). In addition, cell density-based quorum sensing dynamics were included in the model. The model comprises a total of 36 parameters, 14 of which are yield coefficients and 7 of which are substrate affinity and inhibition constants. Of all 36 parameters, 30 were derived from dedicated experimental results, literature, and databases and 6 of them were used as fitting parameters. The model is able to describe data on biomass growth, substrates, and products obtained from a reference batch process and other validation scenarios. The model presented describes the time-course and interrelation of biomass, relevant substrates, and products on a process level while including a kinetic representation of cell density-dependent regulatory mechanisms.

  1. Three-Dimensional Magnetohydrodynamic Modeling of the Solar Wind Including Pickup Protons and Turbulence Transport

    Science.gov (United States)

    Usmanov, Arcadi V.; Goldstein, Melvyn L.; Matthaeus, William H.

    2012-01-01

    To study the effects of interstellar pickup protons and turbulence on the structure and dynamics of the solar wind, we have developed a fully three-dimensional magnetohydrodynamic solar wind model that treats interstellar pickup protons as a separate fluid and incorporates the transport of turbulence and turbulent heating. The governing system of equations combines the mean-field equations for the solar wind plasma, magnetic field, and pickup protons and the turbulence transport equations for the turbulent energy, normalized cross-helicity, and correlation length. The model equations account for photoionization of interstellar hydrogen atoms and their charge exchange with solar wind protons, energy transfer from pickup protons to solar wind protons, and plasma heating by turbulent dissipation. Separate mass and energy equations are used for the solar wind and pickup protons, though a single momentum equation is employed under the assumption that the pickup protons are comoving with the solar wind protons.We compute the global structure of the solar wind plasma, magnetic field, and turbulence in the region from 0.3 to 100 AU for a source magnetic dipole on the Sun tilted by 0 deg - .90 deg and compare our results with Voyager 2 observations. The results computed with and without pickup protons are superposed to evaluate quantitatively the deceleration and heating effects of pickup protons, the overall compression of the magnetic field in the outer heliosphere caused by deceleration, and the weakening of corotating interaction regions by the thermal pressure of pickup protons.

  2. Codigestion of solid wastes: a review of its uses and perspectives including modeling.

    Science.gov (United States)

    Mata-Alvarez, Joan; Dosta, Joan; Macé, Sandra; Astals, Sergi

    2011-06-01

    The last two years have witnessed a dramatic increase in the number of papers published on the subject of codigestion, highlighting the relevance of this topic within anaerobic digestion research. Consequently, it seems appropriate to undertake a review of codigestion practices starting from the late 1970s, when the first papers related to this concept were published, and continuing to the present day, demonstrating the exponential growth in the interest shown in this approach in recent years. Following a general analysis of the situation, state-of-the-art codigestion is described, focusing on the two most important areas as regards publication: codigestion involving sewage sludge and the organic fraction of municipal solid waste (including a review of the secondary advantages for wastewater treatment plant related to biological nutrient removal), and codigestion in the agricultural sector, that is, including agricultural - farm wastes, and energy crops. Within these areas, a large number of oversized digesters appear which can be used to codigest other substrates, resulting in economic and environmental advantages. Although the situation may be changing, there is still a need for good examples on an industrial scale, particularly with regard to wastewater treatment plants, in order to extend this beneficial practice. In the last section, a detailed analysis of papers addressing the important aspect of modelisation is included. This analysis includes the first codigestion models to be developed as well as recent applications of the standardised anaerobic digestion model ADM1 to codigestion. (This review includes studies ranging from laboratory to industrial scale.).

  3. Enhanced UWB Radio Channel Model for Short-Range Communication Scenarios Including User Dynamics

    DEFF Research Database (Denmark)

    Kovacs, Istvan Zsolt; Nguyen, Tuan Hung; Eggers, Patrick Claus F.

    2005-01-01

    In this paper we propose a SISO UWB radio channel model for short-range radio link scenarios between a fixed device and a dynamic user hand-held device. The channel model is derived based on novel experimental UWB radio propagation investigations carried out in typical indoor PAN scenarios...... including realistic device and user terminal antenna configurations. The radio channel measurements have been performed in the lower UWB frequency band of 3GHz to 5GHz with a 2x4 MIMO antenna configuration. Several environments, user scenarios and two types of user terminals have been used. The developed...

  4. Fuzzy Control of Yaw and Roll Angles of a Simulated Helicopter Model Includes Articulated Manipulators

    Directory of Open Access Journals (Sweden)

    Hossein Sadegh Lafmejani

    2015-09-01

    Full Text Available Fuzzy logic controller (FLC is a heuristic method by If-Then Rules which resembles human intelligence and it is a good method for designing Non-linear control systems. In this paper, an arbitrary helicopter model includes articulated manipulators has been simulated with Matlab SimMechanics toolbox. Due to the difficulties of modeling this complex system, a fuzzy controller with simple fuzzy rules has been designed for its yaw and roll angles in order to stabilize the helicopter while it is in the presence of disturbances or its manipulators are moving for a task. Results reveal that a simple FLC can appropriately control this system.

  5. Including Finite Surface Span Effects in Empirical Jet-Surface Interaction Noise Models

    Science.gov (United States)

    Brown, Clifford A.

    2016-01-01

    The effect of finite span on the jet-surface interaction noise source and the jet mixing noise shielding and reflection effects is considered using recently acquired experimental data. First, the experimental setup and resulting data are presented with particular attention to the role of surface span on far-field noise. These effects are then included in existing empirical models that have previously assumed that all surfaces are semi-infinite. This extended abstract briefly describes the experimental setup and data leaving the empirical modeling aspects for the final paper.

  6. Analytical model for investigation of interior noise characteristics in aircraft with multiple propellers including synchrophasing

    Science.gov (United States)

    Fuller, C. R.

    1986-01-01

    A simplified analytical model of transmission of noise into the interior of propeller-driven aircraft has been developed. The analysis includes directivity and relative phase effects of the propeller noise sources, and leads to a closed form solution for the coupled motion between the interior and exterior fields via the shell (fuselage) vibrational response. Various situations commonly encountered in considering sound transmission into aircraft fuselages are investigated analytically and the results obtained are compared to measurements in real aircraft. In general the model has proved successful in identifying basic mechanisms behind noise transmission phenomena.

  7. Bladder cancer mapping in Libya based on standardized morbidity ratio and log-normal model

    Science.gov (United States)

    Alhdiri, Maryam Ahmed; Samat, Nor Azah; Mohamed, Zulkifley

    2017-05-01

    Disease mapping contains a set of statistical techniques that detail maps of rates based on estimated mortality, morbidity, and prevalence. A traditional approach to measure the relative risk of the disease is called Standardized Morbidity Ratio (SMR). It is the ratio of an observed and expected number of accounts in an area, which has the greatest uncertainty if the disease is rare or if geographical area is small. Therefore, Bayesian models or statistical smoothing based on Log-normal model are introduced which might solve SMR problem. This study estimates the relative risk for bladder cancer incidence in Libya from 2006 to 2007 based on the SMR and log-normal model, which were fitted to data using WinBUGS software. This study starts with a brief review of these models, starting with the SMR method and followed by the log-normal model, which is then applied to bladder cancer incidence in Libya. All results are compared using maps and tables. The study concludes that the log-normal model gives better relative risk estimates compared to the classical method. The log-normal model has can overcome the SMR problem when there is no observed bladder cancer in an area.

  8. An air/sea flux model including the effects of capillary waves

    Science.gov (United States)

    Bourassa, Mark A.

    1993-01-01

    An improved model of the air/sea interface is developed. The improvements consist in including the effect of capillary (surface tension) waves on the tropical surface fluxes and the consideration of the sea state, both of which increase the magnitude of tropical surface fluxes. Changes in surface stress are most significant in the low wind-speed regions, which include the areas where westerly bursts occur. It is shown that the changes, from the regular wind conditions to those of a westerly burst or El-Nino, can double when the effects of capillary waves are considered. This implies a much stronger coupling between the ocean and the atmosphere than is predicted by other boundary layer models.

  9. A complete model of CH+ rotational excitation including radiative and chemical pumping processes

    CERN Document Server

    Godard, Benjamin

    2012-01-01

    Aims. Excitation of far-infrared and submillimetric molecular lines may originate from nonreactive collisions, chemical formation, or far infrared, near-infrared, and optical fluorescences. As a template, we investigate the impact of each of these processes on the excitation of the methylidyne cation CH+ and on the intensities of its rotational transitions recently detected in emission in dense photodissociation regions (PDRs) and in planetary nebulae. Methods. We have developed a nonlocal thermodynamic equilibrium (non-LTE) excitation model that includes the entire energy structure of CH+, i.e. taking into account the pumping of its vibrational and bound and unbound electronic states by near-infrared and optical photons. The model includes the theoretical cross-sections of nonreactive collisions with H, H2, He, and e-, and a Boltzmann distribution is used to describe the probability of populating the excited levels of CH+ during its chemical formation by hydrogenation of C+. To confirm our results we also pe...

  10. A model for heterogeneous traffic flows including non-motorized vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Oketch, T.G.

    2001-07-01

    This study is concerned with developing a traffic flow and emissions model suitable for heterogeneous traffic streams containing motorised and non-motorised vehicles. Such streams contain vehicle types such as private cars, buses and trucks as well as bicycles, motorcycles and other vehicular forms. The model covers the different vehicle types and allows for peculiar behaviours prevalent in such streams. In addition to an existing deterministic car following rule, the model incorporates detailed lateral movement algorithm with gradual lane change manoeuvres, the decisions of which are governed by fuzzy logic rules. For determination of pollutant emissions, the travel lane was divided into finite elements and total emissions aggregated for each element depending on the vehicle speeds and types. A methodology for estimation of emission rates, based on vehicle maintenance history, for countries without reliable inventories was proposed and used to obtain emission coefficients of CO, HC, NOx and Pb emissions in Kenya. In conclusion, the model has demonstrated that heterogeneous traffic can be effectively analysed by approaches that take their peculiar characteristics into consideration. In addition, it has also provided new insight in the performance and emission patterns of heterogeneous traffic streams which can be used to formulate regulatory directives governing the usage of lanes or provision of auxiliary carriageways for slower vehicles. (orig.) [German] In dieser Arbeit wurde ein Verkehrsfluss- und Emissions-Model fuer heterogene Verkehrsstroeme entwickelt. Solche Verkehrsstroeme enthalten nicht nur motorisierte Fahrzeuge wie Pkw, Lkw, Omnibus, Motorrad usw. sondern auch nicht-motorisierte Fahrzeuge wie Fahrrad und auch besondere Fahrzeugtypen, die auf Motorraedern oder Fahrraedern basieren. Im Modell wurden auch die entsprechenden besonderen Verhaeltnisse dieser Fahrzeugtypen beruecksichtigt. Die Bewegung von Fahrzeugen wurde in zwei Dimensionen modelliert. Auf

  11. Including Flocculation in a Numerical Sediment Transport Model for a Partially-Mixed Estuary

    Science.gov (United States)

    Tarpley, D.; Harris, C. K.; Friedrichs, C. T.

    2016-12-01

    Particle settling velocity impacts the transport of suspended sediment to the first order but fine-grained material like muds tend to form loosely bound aggregates (flocs) whose settling velocity can vary widely. Properties of flocculated sediment such as settling velocity and particle density are difficult to predict because they change in response to several factors including salinity, suspended sediment concentration, turbulent mixing, and organic content. Knowledge of the mechanisms governing flocculation of cohesive sediment is rapidly expanding; especially in response to recent technical advances. As the understanding of particle dynamics progresses, numerical models describing flocculation and break-up are being developed with varying degrees of complexity. While complex models capture the dynamics of the system, their computational costs may prohibit their incorporation into larger model domains. It is important to determine if the computational costs of intricate floc models are justifiable compared to simpler formulations. For this study, we implement an idealized two-dimensional model designed to represent a longitudinal section of a partially mixed estuary that neglects across-channel variation but exhibits salinity driven estuarine circulation. The idealized domain is designed to mimic the primary features of the York River, VA. Suspended load, erosion and deposition are calculated within the sediment transport routines of the COAWST modeling system. We compare different methods for prescribing settling velocity of fine-grained material. The simplest, standard model neglects flocculation dynamics while the complex treatment is a size-class-based flocculation model (FLOCMOD). Differences in tidal and daily averages of suspended load, bulk settling velocity and bed deposition are compared between the standard and FLOCMOD runs, to examine the relative impact of flocculation on sediment transport patterns. We expect FLOCMOD to have greater variability and

  12. Multistate Statistical Modeling: A Tool to Build a Lung Cancer Microsimulation Model That Includes Parameter Uncertainty and Patient Heterogeneity.

    Science.gov (United States)

    Bongers, Mathilda L; de Ruysscher, Dirk; Oberije, Cary; Lambin, Philippe; Uyl-de Groot, Carin A; Coupé, V M H

    2016-01-01

    With the shift toward individualized treatment, cost-effectiveness models need to incorporate patient and tumor characteristics that may be relevant to treatment planning. In this study, we used multistate statistical modeling to inform a microsimulation model for cost-effectiveness analysis of individualized radiotherapy in lung cancer. The model tracks clinical events over time and takes patient and tumor features into account. Four clinical states were included in the model: alive without progression, local recurrence, metastasis, and death. Individual patients were simulated by repeatedly sampling a patient profile, consisting of patient and tumor characteristics. The transitioning of patients between the health states is governed by personalized time-dependent hazard rates, which were obtained from multistate statistical modeling (MSSM). The model simulations for both the individualized and conventional radiotherapy strategies demonstrated internal and external validity. Therefore, MSSM is a useful technique for obtaining the correlated individualized transition rates that are required for the quantification of a microsimulation model. Moreover, we have used the hazard ratios, their 95% confidence intervals, and their covariance to quantify the parameter uncertainty of the model in a correlated way. The obtained model will be used to evaluate the cost-effectiveness of individualized radiotherapy treatment planning, including the uncertainty of input parameters. We discuss the model-building process and the strengths and weaknesses of using MSSM in a microsimulation model for individualized radiotherapy in lung cancer.

  13. Model for safety reports including descriptive examples; Mall foer saekerhetsrapporter med beskrivande exempel

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-01

    Several safety reports will be produced in the process of planning and constructing the system for disposal of high-level radioactive waste in Sweden. The present report gives a model, with detailed examples, of how these reports should be organized and what steps they should include. In the near future safety reports will deal with the encapsulation plant and the repository. Later reports will treat operation of the handling systems and the repository.

  14. Extending the formal model of a spatial data infrastructure to include volunteered geographical information

    CSIR Research Space (South Africa)

    Cooper, Antony K

    2011-07-01

    Full Text Available an aggregator of VGI, such as Ushahidi, and the provider of the infrastructure for collecting VGI, such as OpenStreetMap. 3) Broker: A stakeholder who brings End Users and Providers together and assists in the negotiation of contracts between them... model of a spatial data infrastructure to include volunteered geographical information Antony K Cooper*, Petr Rapant?, Jan Hjelmager?, Dominique Laurent?, Adam Iwaniak#, Serena Coetzee$, Harold Moellering? and Ulrich D?ren? *Logistics...

  15. Discrete element modeling of Martian pit crater formation in response to extensional fracturing and dilational normal faulting

    Science.gov (United States)

    Smart, Kevin J.; Wyrick, Danielle Y.; Ferrill, David A.

    2011-04-01

    Pit craters, circular to elliptical depressions that lack a raised rim or ejecta deposits, are common on the surface of Mars. Similar structures are also found on Earth, Venus, the Moon, and smaller planetary bodies, including some asteroids. While it is generally accepted that these pits form in response to material drainage into a subsurface void space, the primary mechanism(s) responsible for creating the void is a subject of debate. Previously proposed mechanisms include collapse into lave tubes, dike injection, extensional fracturing, and dilational normal faulting. In this study, we employ two-dimensional discrete element models to assess both extensional fracturing and dilational normal faulting as mechanisms for forming pit craters. We also examine the effect of mechanical stratigraphy (alternating strong and weak layers) and variation in regolith thickness on pit morphology. Our simulations indicate that both extensional fracturing and dilational normal faulting are viable mechanisms. Both mechanisms lead to generally convex (steepening downward) slope profiles; extensional fracturing results in generally symmetric pits, whereas dilational normal faulting produces strongly asymmetric geometries. Pit width is established early, whereas pit depth increases later in the deformation history. Inclusion of mechanical stratigraphy results in wider and deeper pits, particularly for the dilational normal faulting, and the presence of strong near-surface layers leads to pits with distinct edges as observed on Mars. The modeling results suggest that a thicker regolith leads to wider but shallower pits that are less distinct and may be more difficult to detect in areas of thick regolith.

  16. QCD Equation of State From a Chiral Hadronic Model Including Quark Degrees of Freedom

    CERN Document Server

    Rau, Philip; Schramm, Stefan; Stöcker, Horst

    2013-01-01

    This work presents an effective model for strongly interacting matter and the QCD equation of state (EoS). The model includes both hadron and quark degrees of freedom and takes into account the transition of chiral symmetry restoration as well as the deconfinement phase transition. At low temperatures $T$ and baryonic densities $\\rho_B$ a hadron resonance gas is described using a SU(3)-flavor sigma-omega model and a quark phase is introduced in analogy to PNJL models for higher $T$ and $\\rho_B$. In this way, the correct asymptotic degrees of freedom are used in a wide range of $T$ and $\\rho_B$. Here, results of this model concerning the chiral and deconfinement phase transitions and thermodynamic model properties are presented. Large hadron resonance multiplicities in the transition region emphasize the importance of heavy-mass resonance states in this region and their impact on the chiral transition behavior. The resulting phase diagram of QCD matter at small chemical potentials is in line with latest lattic...

  17. A full model for simulation of electrochemical cells including complex behavior

    Science.gov (United States)

    Esperilla, J. J.; Félez, J.; Romero, G.; Carretero, A.

    This communication presents a model of electrochemical cells developed in order to simulate their electrical, chemical and thermal behavior showing the differences when thermal effects are or not considered in the charge-discharge process. The work presented here has been applied to the particular case of the Pb,PbSO 4|H 2SO 4 (aq)|PbO 2,Pb cell, which forms the basis of the lead-acid batteries so widely used in the automotive industry and as traction batteries in electric or hybrid vehicles. Each half-cell is considered independently in the model. For each half-cell, in addition to the main electrode reaction, a secondary reaction is considered: the hydrogen evolution reaction in the negative electrode and the oxygen evolution reaction in the positive. The equilibrium potential is calculated with the Nernst equation, in which the activity coefficients are fitted to an exponential function using experimental data. On the other hand, the two main mechanisms that produce the overpotential are considered, that is the activation or charge transfer and the diffusion mechanisms. First, an isothermal model has been studied in order to show the behavior of the main phenomena. A more complex model has also been studied including thermal behavior. This model is very useful in the case of traction batteries in electric and hybrid vehicles where high current intensities appear. Some simulation results are also presented in order to show the accuracy of the proposed models.

  18. A High-Rate, Single-Crystal Model including Phase Transformations, Plastic Slip, and Twinning

    Energy Technology Data Exchange (ETDEWEB)

    Addessio, Francis L. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Bronkhorst, Curt Allan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Bolme, Cynthia Anne [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Explosive Science and Shock Physics Division; Brown, Donald William [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Materials Science and Technology Division; Cerreta, Ellen Kathleen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Materials Science and Technology Division; Lebensohn, Ricardo A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Materials Science and Technology Division; Lookman, Turab [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Luscher, Darby Jon [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Mayeur, Jason Rhea [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Morrow, Benjamin M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Materials Science and Technology Division; Rigg, Paulo A. [Washington State Univ., Pullman, WA (United States). Dept. of Physics. Inst. for Shock Physics

    2016-08-09

    An anisotropic, rate-­dependent, single-­crystal approach for modeling materials under the conditions of high strain rates and pressures is provided. The model includes the effects of large deformations, nonlinear elasticity, phase transformations, and plastic slip and twinning. It is envisioned that the model may be used to examine these coupled effects on the local deformation of materials that are subjected to ballistic impact or explosive loading. The model is formulated using a multiplicative decomposition of the deformation gradient. A plate impact experiment on a multi-­crystal sample of titanium was conducted. The particle velocities at the back surface of three crystal orientations relative to the direction of impact were measured. Molecular dynamics simulations were conducted to investigate the details of the high-­rate deformation and pursue issues related to the phase transformation for titanium. Simulations using the single crystal model were conducted and compared to the high-­rate experimental data for the impact loaded single crystals. The model was found to capture the features of the experiments.

  19. A 3D model of the oculomotor plant including the pulley system

    Energy Technology Data Exchange (ETDEWEB)

    Viegener, A; Armentano, R L [Fundacion Universitaria Dr. Rene G. Favaloro, SolIs 453 (1078) Buenos Aires (Argentina)

    2007-11-15

    Early models of the oculomotor plant only considered the eye globes and the muscles that move them. Recently, connective tissue structures have been found enveloping the extraocular muscles (EOMs) and firmly anchored to the orbital wall. These structures act as pulleys; they determine the functional origin of the EOMs and, in consequence, their effective pulling direction. A three dimensional model of the oculomotor plant, including pulleys, has been developed and simulations in Simulink were performed during saccadic eye movements. Listing's law was implemented based on the supposition that there exists an eye orientation related signal. The inclusion of the pulleys in the model makes this assumption plausible and simplifies the problem of the plant noncommutativity.

  20. A flexible and qualitatively stable model for cell cycle dynamics including DNA damage effects.

    Science.gov (United States)

    Jeffries, Clark D; Johnson, Charles R; Zhou, Tong; Simpson, Dennis A; Kaufmann, William K

    2012-01-01

    This paper includes a conceptual framework for cell cycle modeling into which the experimenter can map observed data and evaluate mechanisms of cell cycle control. The basic model exhibits qualitative stability, meaning that regardless of magnitudes of system parameters its instances are guaranteed to be stable in the sense that all feasible trajectories converge to a certain trajectory. Qualitative stability can also be described by the signs of real parts of eigenvalues of the system matrix. On the biological side, the resulting model can be tuned to approximate experimental data pertaining to human fibroblast cell lines treated with ionizing radiation, with or without disabled DNA damage checkpoints. Together these properties validate a fundamental, first order systems view of cell dynamics. Classification Codes: 15A68.

  1. RELAP5-3D Code Includes Athena Features and Models

    Energy Technology Data Exchange (ETDEWEB)

    Richard A. Riemke; Cliff B. Davis; Richard R. Schultz

    2006-07-01

    Version 2.3 of the RELAP5-3D computer program includes all features and models previously available only in the ATHENA version of the code. These include the addition of new working fluids (i.e., ammonia, blood, carbon dioxide, glycerol, helium, hydrogen, lead-bismuth, lithium, lithium-lead, nitrogen, potassium, sodium, and sodium-potassium) and a magnetohydrodynamic model that expands the capability of the code to model many more thermal-hydraulic systems. In addition to the new working fluids along with the standard working fluid water, one or more noncondensable gases (e.g., air, argon, carbon dioxide, carbon monoxide, helium, hydrogen, krypton, nitrogen, oxygen, sf6, xenon) can be specified as part of the vapor/gas phase of the working fluid. These noncondensable gases were in previous versions of RELAP5- 3D. Recently four molten salts have been added as working fluids to RELAP5-3D Version 2.4, which has had limited release. These molten salts will be in RELAP5-3D Version 2.5, which will have a general release like RELAP5-3D Version 2.3. Applications that use these new features and models are discussed in this paper.

  2. Including policy and management in socio-hydrology models: initial conceptualizations

    Science.gov (United States)

    Hermans, Leon; Korbee, Dorien

    2017-04-01

    Socio-hydrology studies the interactions in coupled human-water systems. So far, the use of dynamic models that capture the direct feedback between societal and hydrological systems has been dominant. What has not yet been included with any particular emphasis, is the policy or management layer, which is a central element in for instance integrated water resources management (IWRM) or adaptive delta management (ADM). Studying the direct interactions between human-water systems generates knowledges that eventually helps influence these interactions in ways that may ensure better outcomes - for society and for the health and sustainability of water systems. This influence sometimes occurs through spontaneous emergence, uncoordinated by societal agents - private sector, citizens, consumers, water users. However, the term 'management' in IWRM and ADM also implies an additional coordinated attempt through various public actors. This contribution is a call to include the policy and management dimension more prominently into the research focus of the socio-hydrology field, and offers first conceptual variables that should be considered in attempts to include this policy or management layer in socio-hydrology models. This is done by drawing on existing frameworks to study policy processes throughout both planning and implementation phases. These include frameworks such as the advocacy coalition framework, collective learning and policy arrangements, which all emphasis longer-term dynamics and feedbacks between actor coalitions in strategic planning and implementation processes. A case about longter-term dynamics in the management of the Haringvliet in the Netherlands is used to illustrate the paper.

  3. EXACT SOLUTIONS FOR NONLINEAR TRANSIENT FLOW MODEL INCLUDING A QUADRATIC GRADIENT TERM

    Institute of Scientific and Technical Information of China (English)

    曹绪龙; 同登科; 王瑞和

    2004-01-01

    The models of the nonlinear radial flow for the infinite and finite reservoirs including a quadratic gradient term were presented. The exact solution was given in real space for flow equation including quadratic gradiet term for both constant-rate and constant pressure production cases in an infinite system by using generalized Weber transform. Analytical solutions for flow equation including quadratic gradient term were also obtained by using the Hankel transform for a finite circular reservoir case. Both closed and constant pressure outer boundary conditions are considered. Moreover, both constant rate and constant pressure inner boundary conditions are considered. The difference between the nonlinear pressure solution and linear pressure solution is analyzed. The difference may be reached about 8% in the long time. The effect of the quadratic gradient term in the large time well test is considered.

  4. Partial duplication of 18q including a distal critical region for Edwards Syndrome in a patient with normal phenotype and oligoasthenospermia: case report.

    Science.gov (United States)

    Quiroga, R; Monfort, S; Oltra, S; Ferrer-Bolufer, I; Roselló, M; Mayo, S; Martinez, F; Orellana, C

    2011-01-01

    Several authors have attempted to construct a phenotype map for duplications of different portions of chromosome 18 to identify a possible critical region (CR) for Edwards Syndrome. Partial duplications of 18q have been reported in the literature involving the distal CR in patients with some clinical features of Edwards Syndrome. Here, we describe a phenotypically normal male with a large duplication on chromosome 18 that involves the proposed distal CR. The lack of clinical features is remarkable, except for pathological semen analysis, which suggests that terminal 17.4 Mb of 18q do not contain the Edwards Syndrome CR. Alternatively, unknown modifier factors or undetected somatic mosaicism might cause incomplete penetrance of this duplication.

  5. Normal Inverse Gaussian Model-Based Image Denoising in the NSCT Domain

    Directory of Open Access Journals (Sweden)

    Jian Jia

    2015-01-01

    Full Text Available The objective of image denoising is to retain useful details while removing as much noise as possible to recover an original image from its noisy version. This paper proposes a novel normal inverse Gaussian (NIG model-based method that uses a Bayesian estimator to carry out image denoising in the nonsubsampled contourlet transform (NSCT domain. In the proposed method, the NIG model is first used to describe the distributions of the image transform coefficients of each subband in the NSCT domain. Then, the corresponding threshold function is derived from the model using Bayesian maximum a posteriori probability estimation theory. Finally, optimal linear interpolation thresholding algorithm (OLI-Shrink is employed to guarantee a gentler thresholding effect. The results of comparative experiments conducted indicate that the denoising performance of our proposed method in terms of peak signal-to-noise ratio is superior to that of several state-of-the-art methods, including BLS-GSM, K-SVD, BivShrink, and BM3D. Further, the proposed method achieves structural similarity (SSIM index values that are comparable to those of the block-matching 3D transformation (BM3D method.

  6. Modeling the response of normal and ischemic cardiac tissue to electrical stimulation

    Science.gov (United States)

    Kandel, Sunil Mani

    Heart disease, the leading cause of death worldwide, is often caused by ventricular fibrillation. A common treatment for this lethal arrhythmia is defibrillation: a strong electrical shock that resets the heart to its normal rhythm. To design better defibrillators, we need a better understanding of both fibrillation and defibrillation. Fundamental mysteries remain regarding the mechanism of how the heart responds to a shock, particularly anodal shocks and the resultant hyperpolarization. Virtual anodes play critical roles in defibrillation, and one cannot build better defibrillators until these mechanisms are understood. We are using mathematical modeling to numerically simulate observed phenomena, and are exploring fundamental mechanisms responsible for the heart's electrical behavior. Such simulations clarify mechanisms and identify key parameters. We investigate how systolic tissue responds to an anodal shock and how refractory tissue reacts to hyperpolarization by studying the dip in the anodal strength-interval curve. This dip is due to electrotonic interaction between regions of depolarization and hyperpolarization following a shock. The dominance of the electrotonic mechanism over calcium interactions implies the importance of the spatial distribution of virtual electrodes. We also investigate the response of localized ischemic tissue to an anodal shock by modeling a regional elevation of extracellular potassium concentration. This heterogeneity leads to action potential instability, 2:1 conduction block (alternans), and reflection-like reentry at the boarder of the normal and ischemic regions. This kind of reflection (reentry) occurs due to the delay between proximal and distal segments to re-excite the proximal segment. Our numerical simulations are based on the bidomain model, the state-of-the-art mathematical description of how cardiac tissue responds to shocks. The dynamic LuoRudy model describes the active properties of the membrane. To model ischemia

  7. Multicompartmental model for iodide, thyroxine, and triiodothyronine metabolism in normal and spontaneously hyperthyroid cats

    Energy Technology Data Exchange (ETDEWEB)

    Hays, M.T.; Broome, M.R.; Turrel, J.M.

    1988-06-01

    A comprehensive multicompartmental kinetic model was developed to account for the distribution and metabolism of simultaneously injected radioactive iodide (iodide*), T3 (T3*), and T4 (T4*) in six normal and seven spontaneously hyperthyroid cats. Data from plasma samples (analyzed by HPLC), urine, feces, and thyroid accumulation were incorporated into the model. The submodels for iodide*, T3*, and T4* all included both a fast and a slow exchange compartment connecting with the plasma compartment. The best-fit iodide* model also included a delay compartment, presumed to be pooling of gastrosalivary secretions. This delay was 62% longer in the hyperthyroid cats than in the euthyroid cats. Unexpectedly, all of the exchange parameters for both T4 and T3 were significantly slowed in hyperthyroidism, possibly because the hyperthyroid cats were older. None of the plasma equivalent volumes of the exchange compartments of iodide*, T3*, or T4* was significantly different in the hyperthyroid cats, although the plasma equivalent volume of the fast T4 exchange compartments were reduced. Secretion of recycled T4* from the thyroid into the plasma T4* compartment was essential to model fit, but its quantity could not be uniquely identified in the absence of multiple thyroid data points. Thyroid secretion of T3* was not detectable. Comparing the fast and slow compartments, there was a shift of T4* deiodination into the fast exchange compartment in hyperthyroidism. Total body mean residence times (MRTs) of iodide* and T3* were not affected by hyperthyroidism, but mean T4* MRT was decreased 23%. Total fractional T4 to T3 conversion was unchanged in hyperthyroidism, although the amount of T3 produced by this route was increased nearly 5-fold because of higher concentrations of donor stable T4.

  8. SPheno 3.1: extensions including flavour, CP-phases and models beyond the MSSM

    Science.gov (United States)

    Porod, W.; Staub, F.

    2012-11-01

    We describe recent extensions of the program SPhenoincluding flavour aspects, CP-phases, R-parity violation and low energy observables. In case of flavour mixing all masses of supersymmetric particles are calculated including the complete flavour structure and all possible CP-phases at the 1-loop level. We give details on implemented seesaw models, low energy observables and the corresponding extension of the SUSY Les Houches Accord. Moreover, we comment on the possibilities to include MSSM extensions in SPheno. Catalogue identifier: ADRV_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADRV_v2_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 154062 No. of bytes in distributed program, including test data, etc.: 1336037 Distribution format: tar.gz Programming language: Fortran95. Computer: PC running under Linux, should run in every Unix environment. Operating system: Linux, Unix. Classification: 11.6. Catalogue identifier of previous version: ADRV_v1_0 Journal reference of previous version: Comput. Phys. Comm. 153(2003)275 Does the new version supersede the previous version?: Yes Nature of problem: The first issue is the determination of the masses and couplings of supersymmetric particles in various supersymmetric models, the R-parity conserved MSSM with generation mixing and including CP-violating phases, various seesaw extensions of the MSSM and the MSSM with bilinear R-parity breaking. Low energy data on Standard Model fermion masses, gauge couplings and electroweak gauge boson masses serve as constraints. Radiative corrections from supersymmetric particles to these inputs must be calculated. Theoretical constraints on the soft SUSY breaking parameters from a high scale theory are imposed and the parameters at the electroweak scale are obtained from the

  9. DISPLAY-2: a two-dimensional shallow layer model for dense gas dispersion including complex features.

    Science.gov (United States)

    Venetsanos, A G; Bartzis, J G; Würtz, J; Papailiou, D D

    2003-04-25

    A two-dimensional shallow layer model has been developed to predict dense gas dispersion, under realistic conditions, including complex features such as two-phase releases, obstacles and inclined ground. The model attempts to predict the time and space evolution of the cloud formed after a release of a two-phase pollutant into the atmosphere. The air-pollutant mixture is assumed ideal. The cloud evolution is described mathematically through the Cartesian, two-dimensional, shallow layer conservation equations for mixture mass, mixture momentum in two horizontal directions, total pollutant mass fraction (vapor and liquid) and mixture internal energy. Liquid mass fraction is obtained assuming phase equilibrium. Account is taken in the conservation equations for liquid slip and eventual liquid rainout through the ground. Entrainment of ambient air is modeled via an entrainment velocity model, which takes into account the effects of ground friction, ground heat transfer and relative motion between cloud and surrounding atmosphere. The model additionally accounts for thin obstacles effects in three ways. First a stepwise description of the obstacle is generated, following the grid cell faces, taking into account the corresponding area blockage. Then obstacle drag on the passing cloud is modeled by adding flow resistance terms in the momentum equations. Finally the effect of extra vorticity generation and entrainment enhancement behind obstacles is modeled by adding locally into the entrainment formula without obstacles, a characteristic velocity scale defined from the obstacle pressure drop and the local cloud height.The present model predictions have been compared against theoretical results for constant volume and constant flux gravity currents. It was found that deviations of the predicted cloud footprint area change with time from the theoretical were acceptably small, if one models the frictional forces between cloud and ambient air, neglecting the Richardson

  10. Sensitivity of an atmospheric photochemistry model to chlorine perturbations including consideration of uncertainty propagation

    Science.gov (United States)

    Stolarski, R. S.; Douglass, A. R.

    1986-01-01

    Models of stratospheric photochemistry are generally tested by comparing their predictions for the composition of the present atmosphere with measurements of species concentrations. These models are then used to make predictions of the atmospheric sensitivity to perturbations. Here the problem of the sensitivity of such a model to chlorine perturbations ranging from the present influx of chlorine-containing compounds to several times that influx is addressed. The effects of uncertainties in input parameters, including reaction rate coefficients, cross sections, solar fluxes, and boundary conditions, are evaluated using a Monte Carlo method in which the values of the input parameters are randomly selected. The results are probability distributions for present atmosheric concentrations and for calculated perturbations due to chlorine from fluorocarbons. For more than 300 Monte Carlo runs the calculated ozone perturbation for continued emission of fluorocarbons at today's rates had a mean value of -6.2 percent, with a 1-sigma width of 5.5 percent. Using the same runs but only allowing the cases in which the calculated present atmosphere values of NO, NO2, and ClO at 25 km altitude fell within the range of measurements yielded a mean ozone depletion of -3 percent, with a 1-sigma deviation of 2.2 percent. The model showed a nonlinear behavior as a function of added fluorocarbons. The mean of the Monte Carlo runs was less nonlinear than the model run using mean value of the input parameters.

  11. Health Promotion Behavior of Chinese International Students in Korea Including Acculturation Factors: A Structural Equation Model.

    Science.gov (United States)

    Kim, Sun Jung; Yoo, Il Young

    2016-03-01

    The purpose of this study was to explain the health promotion behavior of Chinese international students in Korea using a structural equation model including acculturation factors. A survey using self-administered questionnaires was employed. Data were collected from 272 Chinese students who have resided in Korea for longer than 6 months. The data were analyzed using structural equation modeling. The p value of final model is .31. The fitness parameters of the final model such as goodness of fit index, adjusted goodness of fit index, normed fit index, non-normed fit index, and comparative fit index were more than .95. Root mean square of residual and root mean square error of approximation also met the criteria. Self-esteem, perceived health status, acculturative stress and acculturation level had direct effects on health promotion behavior of the participants and the model explained 30.0% of variance. The Chinese students in Korea with higher self-esteem, perceived health status, acculturation level, and lower acculturative stress reported higher health promotion behavior. The findings can be applied to develop health promotion strategies for this population. Copyright © 2016. Published by Elsevier B.V.

  12. S5-4: Formal Modeling of Affordance in Human-Included Systems

    Directory of Open Access Journals (Sweden)

    Namhun Kim

    2012-10-01

    Full Text Available In spite of it being necessary for humans to consider modeling, analysis, and control of human-included systems, it has been considered a challenging problem because of the critical role of humans in complex systems and of humans' capability of executing unanticipated actions–both beneficial and detrimental ones. Thus, to provide systematic approaches to modeling human actions as a part of system behaviors, a formal modeling framework for human-involved systems in which humans play a controlling role based on their perceptual information is presented. The theory of affordance provides definitions of human actions and their associated properties; Finite State Automata (FSA based modeling is capable of mapping nondeterministic humans into computable components in the system representation. In this talk, we investigate the role of perception in human actions in the system operation and examine the representation of perceptual elements in affordance-based modeling formalism. The proposed framework is expected to capture the natural ways in which humans participate in the system as part of its operation. A human-machine cooperative manufacturing system control example and a human agent simulation example will be introduced for the illustrative purposes at the end of the presentation.

  13. Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies

    Energy Technology Data Exchange (ETDEWEB)

    Ana J. Molinari; Romina F. Aromando; Maria E. Itoiz; Marcela A. Garabalino; Andrea Monti Hughes; Elisa M. Heber; Emiliano C. C. Pozzi; David W. Nigg; Veronica A. Trivillin; Amanda E. Schwint

    2012-07-01

    Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer. Materials and Methods: Tumor-bearing hamsters were treated with thalidomide and were compared with controls. Results: Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than those of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor blood vessel morphology in histological sections, labeled for Factor VIII, revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window of 48 h. Conclusion: The technique developed herein has rendered the hamster oral cancer model amenable to research, with the potential benefit of vascular normalization in head and neck cancer therapy.

  14. Invariant Measures and Asymptotic Gaussian Bounds for Normal Forms of Stochastic Climate Model

    Institute of Scientific and Technical Information of China (English)

    Yuan YUAN; Andrew J.MAJDA

    2011-01-01

    The systematic development of reduced low-dimensional stochastic climate models from observations or comprehensive high dimensional climate models is an important topic for atmospheric low-frequency variability, climate sensitivity, and improved extended range forecasting. Recently, techniques from applied mathematics have been utilized to systematically derive normal forms for reduced stochastic climate models for low-frequency variables. It was shown that dyad and multiplicative triad interactions combine with the climatological linear operator interactions to produce a normal form with both strong nonlinear cubic dissipation and Correlated Additive and Multiplicative (CAM) stochastic noise. The probability distribution functions (PDFs) of low frequency climate variables exhibit small but significant departure from Gaussianity but have asymptotic tails which decay at most like a Gaussian. Here, rigorous upper bounds with Gaussian decay are proved for the invariant measure of general normal form stochastic models. Asymptotic Gaussian lower bounds are also established under suitable hypotheses.

  15. Landau quantized dynamics and spectra for group-VI dichalcogenides, including a model quantum wire

    Directory of Open Access Journals (Sweden)

    Norman J. M. Horing

    2017-06-01

    Full Text Available This work is concerned with the derivation of the Green’s function for Landau-quantized carriers in the Group-VI dichalcogenides. In the spatially homogeneous case, the Green’s function is separated into a Peierls phase factor and a translationally invariant part which is determined in a closed form integral representation involving only elementary functions. The latter is expanded in an eigenfunction series of Laguerre polynomials. These results for the retarded Green’s function are presented in both position and momentum representations, and yet another closed form representation is derived in circular coordinates in terms of the Bessel wave function of the second kind (not to be confused with the Bessel function. The case of a quantum wire is also addressed, representing the quantum wire in terms of a model one-dimensional δ(x-potential profile. This retarded Green’s function for propagation directly along the wire is determined exactly in terms of the corresponding Green’s function for the system without the δ(x-potential, and the Landau quantized eigenenergy dispersion relation is examined. The thermodynamic Green’s function for the dichalcogenide carriers in a normal magnetic field is formulated here in terms of its spectral weight, and its solution is presented in a momentum/integral representation involving only elementary functions, which is subsequently expanded in Laguerre eigenfunctions and presented in both momentum and position representations.

  16. Landau quantized dynamics and spectra for group-VI dichalcogenides, including a model quantum wire

    Science.gov (United States)

    Horing, Norman J. M.

    2017-06-01

    This work is concerned with the derivation of the Green's function for Landau-quantized carriers in the Group-VI dichalcogenides. In the spatially homogeneous case, the Green's function is separated into a Peierls phase factor and a translationally invariant part which is determined in a closed form integral representation involving only elementary functions. The latter is expanded in an eigenfunction series of Laguerre polynomials. These results for the retarded Green's function are presented in both position and momentum representations, and yet another closed form representation is derived in circular coordinates in terms of the Bessel wave function of the second kind (not to be confused with the Bessel function). The case of a quantum wire is also addressed, representing the quantum wire in terms of a model one-dimensional δ (x ) -potential profile. This retarded Green's function for propagation directly along the wire is determined exactly in terms of the corresponding Green's function for the system without the δ (x ) -potential, and the Landau quantized eigenenergy dispersion relation is examined. The thermodynamic Green's function for the dichalcogenide carriers in a normal magnetic field is formulated here in terms of its spectral weight, and its solution is presented in a momentum/integral representation involving only elementary functions, which is subsequently expanded in Laguerre eigenfunctions and presented in both momentum and position representations.

  17. Nitroglycerin provocation in normal subjects is not a useful human migraine model?

    DEFF Research Database (Denmark)

    Tvedskov, J F; Iversen, Helle Klingenberg; Olesen, J

    2010-01-01

    Provoking delayed migraine with nitroglycerin in migraine sufferers is a cumbersome model. Patients are difficult to recruit, migraine comes on late and variably and only 50-80% of patients develop an attack. A model using normal volunteers would be much more useful, but it should be validated by...

  18. Drift-diffusion model of normal glow discharge in an axial magnetic field

    Science.gov (United States)

    Surzhikov, S. T.

    2016-12-01

    A two-dimensional axisymmetrical computing model is formulated with using of which the mathematical modeling of the normal glow discharge in molecular hydrogen is fulfilled in an axial magnetic field with the induction B = 0.1 T in the pressure range p = 1.25-5 Torr and the current-source electromotive force E = 1-3 kV.

  19. The Asymptotic Posterior Normality of the Latent Trait for Polytomous IRT Models.

    Science.gov (United States)

    Chang, Hua-Hua

    1996-01-01

    H. H. Chang and W. F. Stout (1993) presented a derivation of the asymptotic posterior normality of the latent trait given examinee responses under nonrestrictive nonparametric assumptions for dichotomous item response (IRT) theory models. This paper presents an extension of their results to polytomous IRT models and defines a global information…

  20. American Option Pricing using GARCH models and the Normal Inverse Gaussian distribution

    DEFF Research Database (Denmark)

    Stentoft, Lars Peter

    In this paper we propose a feasible way to price American options in a model with time varying volatility and conditional skewness and leptokurtosis using GARCH processes and the Normal Inverse Gaussian distribution. We show how the risk neutral dynamics can be obtained in this model, we interpre....... In particular, improvements are found when considering the smile in implied standard deviations....

  1. Normal linear models with genetically structured residual variance heterogeneity: a case study

    DEFF Research Database (Denmark)

    Sorensen, Daniel; Waagepetersen, Rasmus Plenge

    2003-01-01

    Normal mixed models with different levels of heterogeneity in the residual variance are fitted to pig litter size data. Exploratory analysis and model assessment is based on examination of various posterior predictive distributions. Comparisons based on Bayes factors and related criteria favour...

  2. An extended gene protein/products Boolean network model including post-transcriptional regulation.

    Science.gov (United States)

    Benso, Alfredo; Di Carlo, Stefano; Politano, Gianfranco; Savino, Alessandro; Vasciaveo, Alessandro

    2014-05-07

    Networks Biology allows the study of complex interactions between biological systems using formal, well structured, and computationally friendly models. Several different network models can be created, depending on the type of interactions that need to be investigated. Gene Regulatory Networks (GRN) are an effective model commonly used to study the complex regulatory mechanisms of a cell. Unfortunately, given their intrinsic complexity and non discrete nature, the computational study of realistic-sized complex GRNs requires some abstractions. Boolean Networks (BNs), for example, are a reliable model that can be used to represent networks where the possible state of a node is a boolean value (0 or 1). Despite this strong simplification, BNs have been used to study both structural and dynamic properties of real as well as randomly generated GRNs. In this paper we show how it is possible to include the post-transcriptional regulation mechanism (a key process mediated by small non-coding RNA molecules like the miRNAs) into the BN model of a GRN. The enhanced BN model is implemented in a software toolkit (EBNT) that allows to analyze boolean GRNs from both a structural and a dynamic point of view. The open-source toolkit is compatible with available visualization tools like Cytoscape and allows to run detailed analysis of the network topology as well as of its attractors, trajectories, and state-space. In the paper, a small GRN built around the mTOR gene is used to demonstrate the main capabilities of the toolkit. The extended model proposed in this paper opens new opportunities in the study of gene regulation. Several of the successful researches done with the support of BN to understand high-level characteristics of regulatory networks, can now be improved to better understand the role of post-transcriptional regulation for example as a network-wide noise-reduction or stabilization mechanisms.

  3. An extended gene protein/products boolean network model including post-transcriptional regulation

    Science.gov (United States)

    2014-01-01

    Background Networks Biology allows the study of complex interactions between biological systems using formal, well structured, and computationally friendly models. Several different network models can be created, depending on the type of interactions that need to be investigated. Gene Regulatory Networks (GRN) are an effective model commonly used to study the complex regulatory mechanisms of a cell. Unfortunately, given their intrinsic complexity and non discrete nature, the computational study of realistic-sized complex GRNs requires some abstractions. Boolean Networks (BNs), for example, are a reliable model that can be used to represent networks where the possible state of a node is a boolean value (0 or 1). Despite this strong simplification, BNs have been used to study both structural and dynamic properties of real as well as randomly generated GRNs. Results In this paper we show how it is possible to include the post-transcriptional regulation mechanism (a key process mediated by small non-coding RNA molecules like the miRNAs) into the BN model of a GRN. The enhanced BN model is implemented in a software toolkit (EBNT) that allows to analyze boolean GRNs from both a structural and a dynamic point of view. The open-source toolkit is compatible with available visualization tools like Cytoscape and allows to run detailed analysis of the network topology as well as of its attractors, trajectories, and state-space. In the paper, a small GRN built around the mTOR gene is used to demonstrate the main capabilities of the toolkit. Conclusions The extended model proposed in this paper opens new opportunities in the study of gene regulation. Several of the successful researches done with the support of BN to understand high-level characteristics of regulatory networks, can now be improved to better understand the role of post-transcriptional regulation for example as a network-wide noise-reduction or stabilization mechanisms. PMID:25080304

  4. A New Speaker Verification Method with GlobalSpeaker Model and Likelihood Score Normalization

    Institute of Scientific and Technical Information of China (English)

    张怡颖; 朱小燕; 张钹

    2000-01-01

    In this paper a new text-independent speaker verification method GSMSV is proposed based on likelihood score normalization. In this novel method a global speaker model is established to represent the universal features of speech and normalize the likelihood score. Statistical analysis demonstrates that this normalization method can remove common factors of speech and bring the differences between speakers into prominence. As a result the equal error rate is decreased significantly,verification procedure is accelerated and system adaptability to speaking speed is improved.

  5. Normal thermal conduction in lattice models with asymmetric harmonic interparticle interactions

    Institute of Scientific and Technical Information of China (English)

    Zhong Yi; Zhang Yong; Wang Jiao; Zhao Hong

    2013-01-01

    We study the thermal conduction behaviors of one-dimensional lattice models with asymmetric harmonic interparticle interactions.Normal thermal conductivity that is independent of system size is observed when the lattice chains are long enough.Because only the harmonic interactions are involved,the result confirms,without ambiguity,that asymmetry plays a key role in normal thermal conduction in one-dimensional momentum conserving lattices.Both equilibrium and nonequilibrium simulations are performed to support the conclusion.

  6. Electrical and electroluminescent characterization of nanometric multilayers of SiOX/SiOY obtained by LPCVD including non-normal emission

    Science.gov (United States)

    Alarcón-Salazar, J.; Zaldívar-Huerta, I. E.; Aceves-Mijares, M.

    2016-06-01

    This work describes the analysis and fabrication by Low Pressure Chemical Vapor Deposition of two light-emitting capacitors (LECs) constituted by nanometric multilayers of silicon-rich oxide. For both structures, seven layers were used: three light emitting layers with 6% silicon excess and four conductive layers with 12% silicon excess for one LEC and the other with 14% silicon excess. Both LECs were annealed at 1100 °C. Both multilayers demonstrate a substantially improved photoluminescent response compared to single emitting layers. A dielectric constant of 4.1 and a trap density of 1016 cm-3 were obtained from capacitance-voltage curves. Analysis of current-voltage and electroluminescence-voltage (EL-V) characteristics indicates that EL initiates under the space-charge-limited current mechanism, and the required voltage to turn on the emission is 38 V which is the trap-free limit voltage. However, EL increases exponentially under the impact ionization and trap-assisted tunneling conduction mechanisms. The electroluminescence spectra for both multilayers show two emission peaks centered in 450 and 700 nm attributed to oxygen defects. Also, the LEC non-normal emission was measured and it behaves like a Lambertian optical source. Both multilayers obtain the values of efficiency in the order of 10-6 which is in good agreement with the values reported in the literature.

  7. General hypothesis and shell model for the synthesis of semiconductor nanotubes, including carbon nanotubes

    Science.gov (United States)

    Mohammad, S. Noor

    2010-09-01

    Semiconductor nanotubes, including carbon nanotubes, have vast potential for new technology development. The fundamental physics and growth kinetics of these nanotubes are still obscured. Various models developed to elucidate the growth suffer from limited applicability. An in-depth investigation of the fundamentals of nanotube growth has, therefore, been carried out. For this investigation, various features of nanotube growth, and the role of the foreign element catalytic agent (FECA) in this growth, have been considered. Observed growth anomalies have been analyzed. Based on this analysis, a new shell model and a general hypothesis have been proposed for the growth. The essential element of the shell model is the seed generated from segregation during growth. The seed structure has been defined, and the formation of droplet from this seed has been described. A modified definition of the droplet exhibiting adhesive properties has also been presented. Various characteristics of the droplet, required for alignment and organization of atoms into tubular forms, have been discussed. Employing the shell model, plausible scenarios for the formation of carbon nanotubes, and the variation in the characteristics of these carbon nanotubes have been articulated. The experimental evidences, for example, for the formation of shell around a core, dipole characteristics of the seed, and the existence of nanopores in the seed, have been presented. They appear to justify the validity of the proposed model. The diversities of nanotube characteristics, fundamentals underlying the creation of bamboo-shaped carbon nanotubes, and the impurity generation on the surface of carbon nanotubes have been elucidated. The catalytic action of FECA on growth has been quantified. The applicability of the proposed model to the nanotube growth by a variety of mechanisms has been elaborated. These mechanisms include the vapor-liquid-solid mechanism, the oxide-assisted growth mechanism, the self

  8. Analysis of electronic models for solar cells including energy resolved defect densities

    Energy Technology Data Exchange (ETDEWEB)

    Glitzky, Annegret

    2010-07-01

    We introduce an electronic model for solar cells including energy resolved defect densities. The resulting drift-diffusion model corresponds to a generalized van Roosbroeck system with additional source terms coupled with ODEs containing space and energy as parameters for all defect densities. The system has to be considered in heterostructures and with mixed boundary conditions from device simulation. We give a weak formulation of the problem. If the boundary data and the sources are compatible with thermodynamic equilibrium the free energy along solutions decays monotonously. In other cases it may be increasing, but we estimate its growth. We establish boundedness and uniqueness results and prove the existence of a weak solution. This is done by considering a regularized problem, showing its solvability and the boundedness of its solutions independent of the regularization level. (orig.)

  9. Nonlinear Acoustics FDTD method including Frequency Power Law Attenuation for Soft Tissue Modeling

    CERN Document Server

    Jiménez, Noé; Sánchez-Morcillo, Víctor; Camarena, Francisco; Hou, Yi; Konofagou, Elisa E

    2014-01-01

    This paper describes a model for nonlinear acoustic wave propagation through absorbing and weakly dispersive media, and its numerical solution by means of finite differences in time domain method (FDTD). The attenuation is based on multiple relaxation processes, and provides frequency dependent absorption and dispersion without using computational expensive convolutional operators. In this way, by using an optimization algorithm the coefficients for the relaxation processes can be obtained in order to fit a frequency power law that agrees the experimentally measured attenuation data for heterogeneous media over the typical frequency range for ultrasound medical applications. Our results show that two relaxation processes are enough to fit attenuation data for most soft tissues in this frequency range including the fundamental and the first ten harmonics. Furthermore, this model can fit experimental attenuation data that do not follow exactly a frequency power law over the frequency range of interest. The main...

  10. Particle-based modeling of heterogeneous chemical kinetics including mass transfer

    Science.gov (United States)

    Sengar, A.; Kuipers, J. A. M.; van Santen, Rutger A.; Padding, J. T.

    2017-08-01

    Connecting the macroscopic world of continuous fields to the microscopic world of discrete molecular events is important for understanding several phenomena occurring at physical boundaries of systems. An important example is heterogeneous catalysis, where reactions take place at active surfaces, but the effective reaction rates are determined by transport limitations in the bulk fluid and reaction limitations on the catalyst surface. In this work we study the macro-micro connection in a model heterogeneous catalytic reactor by means of stochastic rotation dynamics. The model is able to resolve the convective and diffusive interplay between participating species, while including adsorption, desorption, and reaction processes on the catalytic surface. Here we apply the simulation methodology to a simple straight microchannel with a catalytic strip. Dimensionless Damkohler numbers are used to comment on the spatial concentration profiles of reactants and products near the catalyst strip and in the bulk. We end the discussion with an outlook on more complicated geometries and increasingly complex reactions.

  11. Models of epidemics: when contact repetition and clustering should be included

    Directory of Open Access Journals (Sweden)

    Scholz Roland W

    2009-06-01

    Full Text Available Abstract Background The spread of infectious disease is determined by biological factors, e.g. the duration of the infectious period, and social factors, e.g. the arrangement of potentially contagious contacts. Repetitiveness and clustering of contacts are known to be relevant factors influencing the transmission of droplet or contact transmitted diseases. However, we do not yet completely know under what conditions repetitiveness and clustering should be included for realistically modelling disease spread. Methods We compare two different types of individual-based models: One assumes random mixing without repetition of contacts, whereas the other assumes that the same contacts repeat day-by-day. The latter exists in two variants, with and without clustering. We systematically test and compare how the total size of an outbreak differs between these model types depending on the key parameters transmission probability, number of contacts per day, duration of the infectious period, different levels of clustering and varying proportions of repetitive contacts. Results The simulation runs under different parameter constellations provide the following results: The difference between both model types is highest for low numbers of contacts per day and low transmission probabilities. The number of contacts and the transmission probability have a higher influence on this difference than the duration of the infectious period. Even when only minor parts of the daily contacts are repetitive and clustered can there be relevant differences compared to a purely random mixing model. Conclusion We show that random mixing models provide acceptable estimates of the total outbreak size if the number of contacts per day is high or if the per-contact transmission probability is high, as seen in typical childhood diseases such as measles. In the case of very short infectious periods, for instance, as in Norovirus, models assuming repeating contacts will also behave

  12. Standardized Competencies for Parenteral Nutrition Order Review and Parenteral Nutrition Preparation, Including Compounding: The ASPEN Model.

    Science.gov (United States)

    Boullata, Joseph I; Holcombe, Beverly; Sacks, Gordon; Gervasio, Jane; Adams, Stephen C; Christensen, Michael; Durfee, Sharon; Ayers, Phil; Marshall, Neil; Guenter, Peggi

    2016-08-01

    Parenteral nutrition (PN) is a high-alert medication with a complex drug use process. Key steps in the process include the review of each PN prescription followed by the preparation of the formulation. The preparation step includes compounding the PN or activating a standardized commercially available PN product. The verification and review, as well as preparation of this complex therapy, require competency that may be determined by using a standardized process for pharmacists and for pharmacy technicians involved with PN. An American Society for Parenteral and Enteral Nutrition (ASPEN) standardized model for PN order review and PN preparation competencies is proposed based on a competency framework, the ASPEN-published interdisciplinary core competencies, safe practice recommendations, and clinical guidelines, and is intended for institutions and agencies to use with their staff.

  13. A generalized model for optimal transport of images including dissipation and density modulation

    KAUST Repository

    Maas, Jan

    2015-11-01

    © EDP Sciences, SMAI 2015. In this paper the optimal transport and the metamorphosis perspectives are combined. For a pair of given input images geodesic paths in the space of images are defined as minimizers of a resulting path energy. To this end, the underlying Riemannian metric measures the rate of transport cost and the rate of viscous dissipation. Furthermore, the model is capable to deal with strongly varying image contrast and explicitly allows for sources and sinks in the transport equations which are incorporated in the metric related to the metamorphosis approach by Trouvé and Younes. In the non-viscous case with source term existence of geodesic paths is proven in the space of measures. The proposed model is explored on the range from merely optimal transport to strongly dissipative dynamics. For this model a robust and effective variational time discretization of geodesic paths is proposed. This requires to minimize a discrete path energy consisting of a sum of consecutive image matching functionals. These functionals are defined on corresponding pairs of intensity functions and on associated pairwise matching deformations. Existence of time discrete geodesics is demonstrated. Furthermore, a finite element implementation is proposed and applied to instructive test cases and to real images. In the non-viscous case this is compared to the algorithm proposed by Benamou and Brenier including a discretization of the source term. Finally, the model is generalized to define discrete weighted barycentres with applications to textures and objects.

  14. Fluid-structure interaction including volumetric coupling with homogenised subdomains for modeling respiratory mechanics.

    Science.gov (United States)

    Yoshihara, Lena; Roth, Christian J; Wall, Wolfgang A

    2017-04-01

    In this article, a novel approach is presented for combining standard fluid-structure interaction with additional volumetric constraints to model fluid flow into and from homogenised solid domains. The proposed algorithm is particularly interesting for investigations in the field of respiratory mechanics as it enables the mutual coupling of airflow in the conducting part and local tissue deformation in the respiratory part of the lung by means of a volume constraint. In combination with a classical monolithic fluid-structure interaction approach, a comprehensive model of the human lung can be established that will be useful to gain new insights into respiratory mechanics in health and disease. To illustrate the validity and versatility of the novel approach, three numerical examples including a patient-specific lung model are presented. The proposed algorithm proves its capability of computing clinically relevant airflow distribution and tissue strain data at a level of detail that is not yet achievable, neither with current imaging techniques nor with existing computational models. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  15. Empirical Validation of a Thermal Model of a Complex Roof Including Phase Change Materials

    Directory of Open Access Journals (Sweden)

    Stéphane Guichard

    2015-12-01

    Full Text Available This paper deals with the empirical validation of a building thermal model of a complex roof including a phase change material (PCM. A mathematical model dedicated to PCMs based on the heat apparent capacity method was implemented in a multi-zone building simulation code, the aim being to increase the understanding of the thermal behavior of the whole building with PCM technologies. In order to empirically validate the model, the methodology is based both on numerical and experimental studies. A parametric sensitivity analysis was performed and a set of parameters of the thermal model has been identified for optimization. The use of the generic optimization program called GenOpt® coupled to the building simulation code enabled to determine the set of adequate parameters. We first present the empirical validation methodology and main results of previous work. We then give an overview of GenOpt® and its coupling with the building simulation code. Finally, once the optimization results are obtained, comparisons of the thermal predictions with measurements are found to be acceptable and are presented.

  16. Habitability of super-Earth planets around other suns: models including Red Giant Branch evolution.

    Science.gov (United States)

    von Bloh, W; Cuntz, M; Schröder, K-P; Bounama, C; Franck, S

    2009-01-01

    The unexpected diversity of exoplanets includes a growing number of super-Earth planets, i.e., exoplanets with masses of up to several Earth masses and a similar chemical and mineralogical composition as Earth. We present a thermal evolution model for a 10 Earth-mass planet orbiting a star like the Sun. Our model is based on the integrated system approach, which describes the photosynthetic biomass production and takes into account a variety of climatological, biogeochemical, and geodynamical processes. This allows us to identify a so-called photosynthesis-sustaining habitable zone (pHZ), as determined by the limits of biological productivity on the planetary surface. Our model considers solar evolution during the main-sequence stage and along the Red Giant Branch as described by the most recent solar model. We obtain a large set of solutions consistent with the principal possibility of life. The highest likelihood of habitability is found for "water worlds." Only mass-rich water worlds are able to realize pHZ-type habitability beyond the stellar main sequence on the Red Giant Branch.

  17. A transient energy function for power systems including the induction motor model

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A construction method for power system transient energy function is studied in the paper, which is simple and universal, and can unify the forms of some current energy functions. A transient energy function including the induction motor model is derived using the method. The unintegrable term is dealt with to get an approximate energy function. Simulations in a 3-bus system and in the WSCC 4-generator system verify the validity of the proposed energy function. The function can be applied to direct transient stability analysis of multi-machine large power systems and provides a tool for analysis of the interaction between the generator angle stability and the load voltage stability.

  18. A laboratory model of the aortic root flow including the coronary arteries

    Science.gov (United States)

    Querzoli, Giorgio; Fortini, Stefania; Espa, Stefania; Melchionna, Simone

    2016-08-01

    Cardiovascular flows have been extensively investigated by means of in vitro models to assess the prosthetic valve performances and to provide insight into the fluid dynamics of the heart and proximal aorta. In particular, the models for the study of the flow past the aortic valve have been continuously improved by including, among other things, the compliance of the vessel and more realistic geometries. The flow within the sinuses of Valsalva is known to play a fundamental role in the dynamics of the aortic valve since they host a recirculation region that interacts with the leaflets. The coronary arteries originate from the ostia located within two of the three sinuses, and their presence may significantly affect the fluid dynamics of the aortic root. In spite of their importance, to the extent of the authors' knowledge, coronary arteries were not included so far when modeling in vitro the transvalvular aortic flow. We present a pulse duplicator consisting of a passively pulsing ventricle, a compliant proximal aorta, and coronary arteries connected to the sinuses of Valsalva. The coronary flow is modulated by a self-regulating device mimicking the physiological mechanism, which is based on the contraction and relaxation of the heart muscle during the cardiac cycle. Results show that the model reproduces satisfyingly the coronary flow. The analysis of the time evolution of the velocity and vorticity fields within the aortic root reveals the main characteristics of the backflow generated through the aorta in order to feed the coronaries during the diastole. Experiments without coronary flow have been run for comparison. Interestingly, the lifetime of the vortex forming in the sinus of Valsalva during the systole is reduced by the presence of the coronaries. As a matter of fact, at the end of the systole, that vortex is washed out because of the suction generated by the coronary flow. Correspondingly, the valve closure is delayed and faster compared to the case with

  19. Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus.

    Directory of Open Access Journals (Sweden)

    Ming-Jen Lee

    Full Text Available BACKGROUND: Normal-pressure hydrocephalus (NPH is a neurodegenerative disorder that usually occurs late in adult life. Clinically, the cardinal features include gait disturbances, urinary incontinence, and cognitive decline. METHODOLOGY/PRINCIPAL FINDINGS: Herein we report the characterization of a novel mouse model of NPH (designated p23-ST1, created by N-ethyl-N-nitrosourea (ENU-induced mutagenesis. The ventricular size in the brain was measured by 3-dimensional micro-magnetic resonance imaging (3D-MRI and was found to be enlarged. Intracranial pressure was measured and was found to fall within a normal range. A histological assessment and tracer flow study revealed that the cerebral spinal fluid (CSF pathway of p23-ST1 mice was normal without obstruction. Motor functions were assessed using a rotarod apparatus and a CatWalk gait automatic analyzer. Mutant mice showed poor rotarod performance and gait disturbances. Cognitive function was evaluated using auditory fear-conditioned responses with the mutant displaying both short- and long-term memory deficits. With an increase in urination frequency and volume, the mutant showed features of incontinence. Nissl substance staining and cell-type-specific markers were used to examine the brain pathology. These studies revealed concurrent glial activation and neuronal loss in the periventricular regions of mutant animals. In particular, chronically activated microglia were found in septal areas at a relatively young age, implying that microglial activation might contribute to the pathogenesis of NPH. These defects were transmitted in an autosomal dominant mode with reduced penetrance. Using a whole-genome scan employing 287 single-nucleotide polymorphic (SNP markers and further refinement using six additional SNP markers and four microsatellite markers, the causative mutation was mapped to a 5.3-cM region on chromosome 4. CONCLUSIONS/SIGNIFICANCE: Our results collectively demonstrate that the p23-ST1

  20. Cellular automata modelling of austenite grain coarsening during reheating--Ⅰ.Normal grain coarsening

    Institute of Scientific and Technical Information of China (English)

    Wanhua Yu; E.J. Palmiere; S.P. Banks; Jingtao Han

    2004-01-01

    A two-dimensional cellular automaton (CA) model has been developed for the description of the normal grain coarsening process. The probabilistic CA method incorporating Moore's definition of the neighbourhood is used to simulate the normal grain coarsening process with a new transition rule. The model simulates the grain coarsening process in as much detail that is possible,from the point of initial nucleation to subsequent coarsening with computational times. The unique result is that the grain coarsening speed can be controlled by the specific method, this result is vital to model the grain coarsening quantitatively. In order to make this model valid, experimental work has been done to provide solid evidence for this model. Comparison of the modelling result and the experimental result has been carried out.

  1. Including sugar cane in the agro-ecosystem model ORCHIDEE-STICS

    Science.gov (United States)

    Valade, A.; Vuichard, N.; Ciais, P.; Viovy, N.

    2010-12-01

    With 4 million ha currently grown for ethanol in Brazil only, approximately half the global bioethanol production in 2005 (Smeets 2008), and a devoted land area expected to expand globally in the years to come, sugar cane is at the heart of the biofuel debate. Indeed, ethanol made from biomass is currently the most widespread option for alternative transportation fuels. It was originally promoted as a carbon neutral energy resource that could bring energy independence to countries and local opportunities to farmers, until attention was drawn to its environmental and socio-economical drawbacks. It is still not clear to which extent it is a solution or a contributor to climate change mitigation. Dynamic Global Vegetation models can help address these issues and quantify the potential impacts of biofuels on ecosystems at scales ranging from on-site to global. The global agro-ecosystem model ORCHIDEE describes water, carbon and energy exchanges at the soil-atmosphere interface for a limited number of natural and agricultural vegetation types. In order to integrate agricultural management to the simulations and to capture more accurately the specificity of crops' phenology, ORCHIDEE has been coupled with the agronomical model STICS. The resulting crop-oriented vegetation model ORCHIDEE-STICS has been used so far to simulate temperate crops such as wheat, corn and soybean. As a generic ecosystem model, each grid cell can include several vegetation types with their own phenology and management practices, making it suitable to spatial simulations. Here, ORCHIDEE-STICS is altered to include sugar cane as a new agricultural Plant functional Type, implemented and parametrized using the STICS approach. An on-site calibration and validation is then performed based on biomass and flux chamber measurements in several sites in Australia and variables such as LAI, dry weight, heat fluxes and respiration are used to evaluate the ability of the model to simulate the specific

  2. Semiparametric Bayesian inference on skew-normal joint modeling of multivariate longitudinal and survival data.

    Science.gov (United States)

    Tang, An-Min; Tang, Nian-Sheng

    2015-02-28

    We propose a semiparametric multivariate skew-normal joint model for multivariate longitudinal and multivariate survival data. One main feature of the posited model is that we relax the commonly used normality assumption for random effects and within-subject error by using a centered Dirichlet process prior to specify the random effects distribution and using a multivariate skew-normal distribution to specify the within-subject error distribution and model trajectory functions of longitudinal responses semiparametrically. A Bayesian approach is proposed to simultaneously obtain Bayesian estimates of unknown parameters, random effects and nonparametric functions by combining the Gibbs sampler and the Metropolis-Hastings algorithm. Particularly, a Bayesian local influence approach is developed to assess the effect of minor perturbations to within-subject measurement error and random effects. Several simulation studies and an example are presented to illustrate the proposed methodologies.

  3. A range of complex probabilistic models for RNA secondary structure prediction that includes the nearest-neighbor model and more.

    Science.gov (United States)

    Rivas, Elena; Lang, Raymond; Eddy, Sean R

    2012-02-01

    The standard approach for single-sequence RNA secondary structure prediction uses a nearest-neighbor thermodynamic model with several thousand experimentally determined energy parameters. An attractive alternative is to use statistical approaches with parameters estimated from growing databases of structural RNAs. Good results have been reported for discriminative statistical methods using complex nearest-neighbor models, including CONTRAfold, Simfold, and ContextFold. Little work has been reported on generative probabilistic models (stochastic context-free grammars [SCFGs]) of comparable complexity, although probabilistic models are generally easier to train and to use. To explore a range of probabilistic models of increasing complexity, and to directly compare probabilistic, thermodynamic, and discriminative approaches, we created TORNADO, a computational tool that can parse a wide spectrum of RNA grammar architectures (including the standard nearest-neighbor model and more) using a generalized super-grammar that can be parameterized with probabilities, energies, or arbitrary scores. By using TORNADO, we find that probabilistic nearest-neighbor models perform comparably to (but not significantly better than) discriminative methods. We find that complex statistical models are prone to overfitting RNA structure and that evaluations should use structurally nonhomologous training and test data sets. Overfitting has affected at least one published method (ContextFold). The most important barrier to improving statistical approaches for RNA secondary structure prediction is the lack of diversity of well-curated single-sequence RNA secondary structures in current RNA databases.

  4. a New Model for Describing Evolution and Control of Disaster System Including Instantaneous and Continuous Actions

    Science.gov (United States)

    Chen, Chang-Kun; Li, Zhi; Sun, Yun-Feng

    A new model for describing the disaster system including instantaneous and continuous action synchronously has been developed. The model is composed of three primary parts, that is, the impact from its causative disaster events, stochastic noise of disaster node and self-healing function, and every part is modeled concretely in terms of their characteristics in practice. Some key parameters, namely link appearance probability, retardation coefficient, ultimate repair capacity of government, dynamical modes considering different disaster evolving chains, and the positions of link with the specific performance in disaster network system are involved. Combined with a case study, the proposed model is applied to a certain disaster evolution system, and the influence law of different parameters on disaster evolution process, in disaster networks with instantaneous-action and/or continuous-action, is presented and compared. The results indicate that the destructive impact in the networks by link in continuous action is far greater an order of magnitude than that in instantaneous action. If a link in continuous action emerges in the disaster network system, properties of the causative event for the link, link appearance probability and its position in the network all have a notable influence to the severity of the disaster network. In addition, some peculiar phenomena are also commendably observed in the disaster evolution process based on the model, such as the multipeaks emerging in the destroyed rate number curve for some crisis nodes caused by their various inducing paths together with the relevant retardation coefficients, the existence of the critical value for ultimate repair capacity to recover the disaster node, and so on.

  5. ISOLATION OF HEPATIC OVAL CELLS FROM DIFFERENT MODEL RATS INCLUDING DIABETIC RATS

    Institute of Scientific and Technical Information of China (English)

    LU Ying-li; YE Ting-ting; XIA Fang-zhen; WANG Ning-jian; YANG Hua; CHEN Yi

    2009-01-01

    Objective To acquire oval cells (progenitor stem cells) from adult rat liver of different models including diabetic rats. Methods Thirty Sprague-Dawley (SD) rats were divided into 5 groups randomly: control, 2-acetylaminofluorene (2-AAF), 2-AAF+partial hepatectomy (PH), 2-AAF+carbon tetrachloride (CCl4), and diabetic groups. As two-step collagenase perfusion protocol of Seglen, oval cells were isolated by Percoll density gradient centrifugation. Thy1.1 positive cells were sorted by flow cytometry, and then cultured in Dulbeccos minimum Eagles medium (DMEM). Immunofluorescence staining was applied to labelling Thy1.1. Results Different rates of Thy1.1 positive oval cells were found in different rat model groups: 0.5% in 2-AAF, 0.3% in 2-hAAF+PH, 0.2% in 2-AAF+CCl4 , 0.1% in diabetic, and 0.0% in control. Isolated cells adhered to plate with fusiform or polygon as epithelial cells. Conclusion Progenitor stem cells exist in injured liver tissue including those from diabetic rats.

  6. A new prognostic model for cancer-specific survival after radical cystectomy including pretreatment thrombocytosis and standard pathological risk factors.

    Science.gov (United States)

    Todenhöfer, Tilman; Renninger, Markus; Schwentner, Christian; Stenzl, Arnulf; Gakis, Georgios

    2012-12-01

    Study Type - Prognosis (cohort series) Level of Evidence 2a What's known on the subject? and What does the study add? Preoperative thrombocytosis has been identified as a predictor of poor outcome in various cancer types. However, the prognostic role of platelet count in patients with invasive bladder cancer undergoing radical cystectomy is unknown. The present study demonstrates that preoperative thrombocytosis is an independent risk factor for decreased cancer-specific survival after radical treatment of invasive bladder cancer. We developed a new prognostic scoring model for cancer-specific outcomes after radical cystectomy including platelet count and established pathological risk factors. Consideration of platelet count in the final model increased its predictive accuracy significantly. Thrombocytosis may be a useful parameter to include within established international bladder cancer nomograms. •  To investigate the oncological significance of preoperative thrombocytosis in patients with invasive bladder cancer undergoing radical cystectomy, as it has been reported as a marker for aggressive tumour biology in a variety of solid tumours. •  The series comprised 258 patients undergoing radical cystectomy between 1999 and 2010 in whom different clinical and histopathological parameters were assessed. •  Elevated platelet count was defined as >450 × 10(9) /L. •  Based on regression estimates of significant parameters in multivariable analysis a new weighted scoring model was developed to predict cancer-specific outcomes. •  The median follow-up was 30 months (6-116). •  Of the 258 patients, 26 (10.1%) had elevated and 232 (89.9%) had normal platelet count. The 3-year cancer-specific survival in patients with normal and elevated platelet count was 61.5% and 32.7%, respectively (P thrombocytosis (2.68, 1.26-5.14; P= 0.011). •  The 3-year cancer-specific survival in patients with a score 0 (low risk), 1-2 (intermediate risk) and 3

  7. Dynamic modelling and analysis of multi-machine power systems including wind farms

    Science.gov (United States)

    Tabesh, Ahmadreza

    2005-11-01

    This thesis introduces a small-signal dynamic model, based on a frequency response approach, for the analysis of a multi-machine power system with special focus on an induction machine based wind farm. The proposed approach is an alternative method to the conventional eigenvalue analysis method which is widely employed for small-signal dynamic analyses of power systems. The proposed modelling approach is successfully applied and evaluated for a power system that (i) includes multiple synchronous generators, and (ii) a wind farm based on either fixed-speed, variable-speed, or doubly-fed induction machine based wind energy conversion units. The salient features of the proposed method, as compared with the conventional eigenvalue analysis method, are: (i) computational efficiency since the proposed method utilizes the open-loop transfer-function matrix of the system, (ii) performance indices that are obtainable based on frequency response data and quantitatively describe the dynamic behavior of the system, and (iii) capability to formulate various wind energy conversion unit, within a wind farm, in a modular form. The developed small-signal dynamic model is applied to a set of multi-machine study systems and the results are validated based on comparison (i) with digital time-domain simulation results obtained from PSCAD/EMTDC software tool, and (ii) where applicable with eigenvalue analysis results.

  8. A Hydrological Concept including Lateral Water Flow Compatible with the Biogeochemical Model ForSAFE

    Directory of Open Access Journals (Sweden)

    Giuliana Zanchi

    2016-03-01

    Full Text Available The study presents a hydrology concept developed to include lateral water flow in the biogeochemical model ForSAFE. The hydrology concept was evaluated against data collected at Svartberget in the Vindeln Research Forest in Northern Sweden. The results show that the new concept allows simulation of a saturated and an unsaturated zone in the soil as well as water flow that reaches the stream comparable to measurements. The most relevant differences compared to streamflow measurements are that the model simulates a higher base flow in winter and lower flow peaks after snowmelt. These differences are mainly caused by the assumptions made to regulate the percolation at the bottom of the simulated soil columns. The capability for simulating lateral flows and a saturated zone in ForSAFE can greatly improve the simulation of chemical exchange in the soil and export of elements from the soil to watercourses. Such a model can help improve the understanding of how environmental changes in the forest landscape will influence chemical loads to surface waters.

  9. Modeling within-host dynamics of influenza virus infection including immune responses.

    Directory of Open Access Journals (Sweden)

    Kasia A Pawelek

    Full Text Available Influenza virus infection remains a public health problem worldwide. The mechanisms underlying viral control during an uncomplicated influenza virus infection are not fully understood. Here, we developed a mathematical model including both innate and adaptive immune responses to study the within-host dynamics of equine influenza virus infection in horses. By comparing modeling predictions with both interferon and viral kinetic data, we examined the relative roles of target cell availability, and innate and adaptive immune responses in controlling the virus. Our results show that the rapid and substantial viral decline (about 2 to 4 logs within 1 day after the peak can be explained by the killing of infected cells mediated by interferon activated cells, such as natural killer cells, during the innate immune response. After the viral load declines to a lower level, the loss of interferon-induced antiviral effect and an increased availability of target cells due to loss of the antiviral state can explain the observed short phase of viral plateau in which the viral level remains unchanged or even experiences a minor second peak in some animals. An adaptive immune response is needed in our model to explain the eventual viral clearance. This study provides a quantitative understanding of the biological factors that can explain the viral and interferon kinetics during a typical influenza virus infection.

  10. A phase-field model for incoherent martensitic transformations including plastic accommodation processes in the austenite

    Science.gov (United States)

    Kundin, J.; Raabe, D.; Emmerich, H.

    2011-10-01

    If alloys undergo an incoherent martensitic transformation, then plastic accommodation and relaxation accompany the transformation. To capture these mechanisms we develop an improved 3D microelastic-plastic phase-field model. It is based on the classical concepts of phase-field modeling of microelastic problems (Chen, L.Q., Wang Y., Khachaturyan, A.G., 1992. Philos. Mag. Lett. 65, 15-23). In addition to these it takes into account the incoherent formation of accommodation dislocations in the austenitic matrix, as well as their inheritance into the martensitic plates based on the crystallography of the martensitic transformation. We apply this new phase-field approach to the butterfly-type martensitic transformation in a Fe-30 wt%Ni alloy in direct comparison to recent experimental data (Sato, H., Zaefferer, S., 2009. Acta Mater. 57, 1931-1937). It is shown that the therein proposed mechanisms of plastic accommodation during the transformation can indeed explain the experimentally observed morphology of the martensitic plates as well as the orientation between martensitic plates and the austenitic matrix. The developed phase-field model constitutes a general simulations approach for different kinds of phase transformation phenomena that inherently include dislocation based accommodation processes. The approach does not only predict the final equilibrium topology, misfit, size, crystallography, and aspect ratio of martensite-austenite ensembles resulting from a transformation, but it also resolves the associated dislocation dynamics and the distribution, and the size of the crystals itself.

  11. Thomas Kuhn's 'Structure of Scientific Revolutions' applied to exercise science paradigm shifts: example including the Central Governor Model.

    Science.gov (United States)

    Pires, Flávio de Oliveira; de Oliveira Pires, Flávio

    2013-07-01

    According to Thomas Kuhn, the scientific progress of any discipline could be distinguished by a pre-paradigm phase, a normal science phase and a revolution phase. The science advances when a scientific revolution takes place after silent period of normal science and the scientific community moves ahead to a paradigm shift. I suggest there has been a recent change of course in the direction of the exercise science. According to the 'current paradigm', exercise would be probably limited by alterations in either central command or peripheral skeletal muscles, and fatigue would be developed in a task-dependent manner. Instead, the central governor model (GCM) has proposed that all forms of exercise are centrally-regulated, the central nervous system would calculate the metabolic cost required to complete a task in order to avoid catastrophic body failure. Some have criticized the CGM and supported the traditional interpretation, but recently the scientific community appears to have begun an intellectual trajectory to accept this theory. First, the increased number of citations of articles that have supported the CGM could indicate that the community has changed the focus. Second, relevant journals have devoted special editions to promote the debate on subjects challenged by the CGM. Finally, scientists from different fields have recognized mechanisms included in the CGM to understand the exercise limits. Given the importance of the scientific community in demarcating a Kuhnian paradigm shift, I suggest that these three aspects could indicate an increased acceptance of a centrally-regulated effort model, to understand the limits of exercise.

  12. Molecular dynamics study of lipid bilayers modeling the plasma membranes of normal murine thymocytes and leukemic GRSL cells.

    Science.gov (United States)

    Andoh, Yoshimichi; Okazaki, Susumu; Ueoka, Ryuichi

    2013-04-01

    Molecular dynamics (MD) calculations for the plasma membranes of normal murine thymocytes and thymus-derived leukemic GRSL cells in water have been performed under physiological isothermal-isobaric conditions (310.15K and 1 atm) to investigate changes in membrane properties induced by canceration. The model membranes used in our calculations for normal and leukemic thymocytes comprised 23 and 25 kinds of lipids, respectively, including phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, sphingomyelin, lysophospholipids, and cholesterol. The mole fractions of the lipids adopted here were based on previously published experimental values. Our calculations clearly showed that the membrane area was increased in leukemic cells, and that the isothermal area compressibility of the leukemic plasma membranes was double that of normal cells. The calculated membranes of leukemic cells were thus considerably bulkier and softer in the lateral direction compared with those of normal cells. The tilt angle of the cholesterol and the conformation of the phospholipid fatty acid tails both showed a lower level of order in leukemic cell membranes compared with normal cell membranes. The lateral radial distribution function of the lipids also showed a more disordered structure in leukemic cell membranes than in normal cell membranes. These observations all show that, for the present thymocytes, the lateral structure of the membrane is considerably disordered by canceration. Furthermore, the calculated lateral self-diffusion coefficient of the lipid molecules in leukemic cell membranes was almost double that in normal cell membranes. The calculated rotational and wobbling autocorrelation functions also indicated that the molecular motion of the lipids was enhanced in leukemic cell membranes. Thus, here we have demonstrated that the membranes of thymocyte leukemic cells are more disordered and more fluid than normal cell membranes.

  13. A surplus production model including environmental effects: Application to the Senegalese white shrimp stocks

    Science.gov (United States)

    Thiaw, Modou; Gascuel, Didier; Jouffre, Didier; Thiaw, Omar Thiom

    2009-12-01

    In Senegal, two stocks of white shrimp ( Penaeusnotialis) are intensively exploited, one in the north and another in the south. We used surplus production models including environmental effects to analyse their changes in abundance over the past 10 years and to estimate their Maximum Sustainable Yield (MSY) and the related fishing effort ( EMSY). First, yearly abundance indices were estimated from commercial statistics using GLM techniques. Then, two environmental indices were alternatively tested in the model: the coastal upwelling intensity from wind speeds provided by the SeaWifs database and the primary production derived from satellite infrared images of chlorophyll a. Models were fitted, with or without the environmental effect, to the 1996-2005 time series. They express stock abundance and catches as functions of the fishing effort and the environmental index (when considered). For the northern stock, fishing effort and abundance fluctuate over the period without any clear trends. The model based on the upwelling index explains 64.9% of the year-to-year variability. It shows that the stock was slightly overexploited in 2002-2003 and is now close to full exploitation. Stock abundance strongly depends on environmental conditions; consequently, the MSY estimate varies from 300 to 900 tons according to the upwelling intensity. For the southern stock, fishing effort has strongly increased over the past 10 years, while abundance has been reduced 4-fold. The environment has a significant effect on abundance but only explains a small part of the year-to-year variability. The best fit is obtained using the primary production index ( R2 = 0.75), and the stock is now significantly overfished regardless of environmental conditions. MSY varies from 1200 to 1800 tons according to environmental conditions. Finally, in northern Senegal, the upwelling is highly variable from year to year and constitutes the major factor determining productivity. In the south, hydrodynamic

  14. Hybrid discrete-continuum modeling for transport, biofilm development and solid restructuring including electrostatic effects

    Science.gov (United States)

    Prechtel, Alexander; Ray, Nadja; Rupp, Andreas

    2017-04-01

    We want to present an approach for the mathematical, mechanistic modeling and numerical treatment of processes leading to the formation, stability, and turnover of soil micro-aggregates. This aims at deterministic aggregation models including detailed mechanistic pore-scale descriptions to account for the interplay of geochemistry and microbiology, and the link to soil functions as, e.g., the porosity. We therefore consider processes at the pore scale and the mesoscale (laboratory scale). At the pore scale transport by diffusion, advection, and drift emerging from electric forces can be taken into account, in addition to homogeneous and heterogeneous reactions of species. In the context of soil micro-aggregates the growth of biofilms or other glueing substances as EPS (extracellular polymeric substances) is important and affects the structure of the pore space in space and time. This model is upscaled mathematically in the framework of (periodic) homogenization to transfer it to the mesoscale resulting in effective coefficients/parameters there. This micro-macro model thus couples macroscopic equations that describe the transport and fluid flow at the scale of the porous medium (mesoscale) with averaged time- and space-dependent coefficient functions. These functions may be explicitly computed by means of auxiliary cell problems (microscale). Finally, the pore space in which the cell problems are defined is time and space dependent and its geometry inherits information from the transport equation's solutions. The microscale problems rely on versatile combinations of cellular automata and discontiuous Galerkin methods while on the mesoscale mixed finite elements are used. The numerical simulations allow to study the interplay between these processes.

  15. American Option Pricing using GARCH models and the Normal Inverse Gaussian distribution

    DEFF Research Database (Denmark)

    Stentoft, Lars Peter

    In this paper we propose a feasible way to price American options in a model with time varying volatility and conditional skewness and leptokurtosis using GARCH processes and the Normal Inverse Gaussian distribution. We show how the risk neutral dynamics can be obtained in this model, we interpret...... the effect of the riskneutralization, and we derive approximation procedures which allow for a computationally efficient implementation of the model. When the model is estimated on financial returns data the results indicate that compared to the Gaussian case the extension is important. A study of the model...

  16. Asymptotic Normality of LS Estimate in Simple Linear EV Regression Model

    Institute of Scientific and Technical Information of China (English)

    Jixue LIU

    2006-01-01

    Though EV model is theoretically more appropriate for applications in which measurement errors exist, people are still more inclined to use the ordinary regression models and the traditional LS method owing to the difficulties of statistical inference and computation. So it is meaningful to study the performance of LS estimate in EV model.In this article we obtain general conditions guaranteeing the asymptotic normality of the estimates of regression coefficients in the linear EV model. It is noticeable that the result is in some way different from the corresponding result in the ordinary regression model.

  17. Environmental assessment of biofuel chains based on ecosystem modelling, including land-use change effects

    Science.gov (United States)

    Gabrielle, B.; Gagnaire, N.; Massad, R.; Prieur, V.; Python, Y.

    2012-04-01

    The potential greenhouse gas (GHG) savings resulting from the displacement of fossil energy sources by bioenergy mostly hinges on the uncertainty on the magnitude of nitrous oxide (N2O) emissions from arable soils occuring during feedstock production. These emissions are broadly related to fertilizer nitrogen input rates, but largely controlled by soil and climate factors which makes their estimation highly uncertain. Here, we set out to improve estimates of N2O emissions from bioenergy feedstocks by using ecosystem models and measurements and modeling of atmospheric N2O in the greater Paris (France) area. Ground fluxes were measured in two locations to assess the effect of soil type and management, crop type (including lignocellulosics such as triticale, switchgrass and miscanthus), and climate on N2O emission rates and dynamics. High-resolution maps of N2O emissions were generated over the Ile-de-France region (around Paris) with two ecosystem models using geographical databases on soils, weather data, land-use and crop management. The models were tested against ground flux measurements and the emission maps were fed into the atmospheric chemistry-transport model CHIMERE. The maps were tested by comparing the CHIMERE simulations with time series of N2O concentrations measured at various heights above the ground in two locations in 2007. The emissions of N2O, as integrated over the region, were used in a life-cycle assessment of representative biofuel pathways: bioethanol from wheat and sugar-beet (1st generation), and miscanthus (2nd generation chain); bio-diesel from oilseed rape. Effects related to direct and indirect land-use changes (in particular on soil carbon stocks) were also included in the assessment based on various land-use scenarios and literature references. The potential deployment of miscanthus was simulated by assuming it would be grown on the current sugar-beet growing area in Ile-de-France, or by converting land currently under permanent fallow

  18. Existence of the uniformly minimum risk equivariant estimators of parameters in a class of normal linear models

    Institute of Scientific and Technical Information of China (English)

    吴启光; 杨国庆

    2002-01-01

    In this paper, we study the existence of the uniformly minimum risk equivariant (UMRE) estimators of parameters in a class of normal linear models, which include the normal variance components model,the growth curve model, the extended growth curve model, and the seemingly unrelated regression equations model, and so on. The necessary and sufficient conditions are given for the existence of UMRE estimators of the estimable linear functions of regression coefficients, the covariance matrix V and (trV)a, where a> 0is known, in the models under an affine group of transformations for quadratic losses and matrix losses, respectively. Under the (extended) growth curve model and the seemingly unrelated regression equations model,the conclusions given in literature for estimating regression coefficients can be derived by applying the general results in this paper, and the sufficient conditions for non-existence of UMRE estimators of V and tr(V) are expanded to be necessary and sufficient conditions. In addition, the necessary and sufficient conditions that there exist UMRE estimators of parameters in the variance components model are obtained for the first time.

  19. Validation of gyrokinetic modelling of light impurity transport including rotation in ASDEX Upgrade

    CERN Document Server

    Casson, F J; Angioni, C; Camenen, Y; Dux, R; Fable, E; Fischer, R; Geiger, B; Manas, P; Menchero, L; Tardini, G

    2013-01-01

    Upgraded spectroscopic hardware and an improved impurity concentration calculation allow accurate determination of boron density in the ASDEX Upgrade tokamak. A database of boron measurements is compared to quasilinear and nonlinear gyrokinetic simulations including Coriolis and centrifugal rotational effects over a range of H-mode plasma regimes. The peaking of the measured boron profiles shows a strong anti-correlation with the plasma rotation gradient, via a relationship explained and reproduced by the theory. It is demonstrated that the rotodiffusive impurity flux driven by the rotation gradient is required for the modelling to reproduce the hollow boron profiles at higher rotation gradients. The nonlinear simulations validate the quasilinear approach, and, with the addition of perpendicular flow shear, demonstrate that each symmetry breaking mechanism that causes momentum transport also couples to rotodiffusion. At lower rotation gradients, the parallel compressive convection is required to match the mos...

  20. Models that include supercoiling of topological domains reproduce several known features of interphase chromosomes.

    Science.gov (United States)

    Benedetti, Fabrizio; Dorier, Julien; Burnier, Yannis; Stasiak, Andrzej

    2014-03-01

    Understanding the structure of interphase chromosomes is essential to elucidate regulatory mechanisms of gene expression. During recent years, high-throughput DNA sequencing expanded the power of chromosome conformation capture (3C) methods that provide information about reciprocal spatial proximity of chromosomal loci. Since 2012, it is known that entire chromatin in interphase chromosomes is organized into regions with strongly increased frequency of internal contacts. These regions, with the average size of ∼1 Mb, were named topological domains. More recent studies demonstrated presence of unconstrained supercoiling in interphase chromosomes. Using Brownian dynamics simulations, we show here that by including supercoiling into models of topological domains one can reproduce and thus provide possible explanations of several experimentally observed characteristics of interphase chromosomes, such as their complex contact maps.

  1. Modeling and analysis of overmodulation in erbium-doped fiber amplifiers including amplified spontaneous emission

    Science.gov (United States)

    Sharma, Reena; Raghuwanshi, Sanjeev Kumar

    2017-02-01

    Line surveillance and management information in erbium-doped fiber amplifiers (EDFAs) can be broadcast by modulating the amplitude of the low-frequency lightwave information signal, the process termed as overmodulation in the literature. This paper presents systematic solutions for the overmodulated pump and information signal transfer functions for EDFA. It includes amplified spontaneous emission (ASE) that has an impact on outcomes in the high-gain system. To the extent of our belief, the methodical model simulated with the current approach leads to a distinct perspective of an outcome in the respective field. The test bed described here is realistic. It specifically represents the overmodulation behavior in an EDFA under the influence of ASE.

  2. Understanding the implementation of complex interventions in health care: the normalization process model

    Directory of Open Access Journals (Sweden)

    Rogers Anne

    2007-09-01

    Full Text Available Abstract Background The Normalization Process Model is a theoretical model that assists in explaining the processes by which complex interventions become routinely embedded in health care practice. It offers a framework for process evaluation and also for comparative studies of complex interventions. It focuses on the factors that promote or inhibit the routine embedding of complex interventions in health care practice. Methods A formal theory structure is used to define the model, and its internal causal relations and mechanisms. The model is broken down to show that it is consistent and adequate in generating accurate description, systematic explanation, and the production of rational knowledge claims about the workability and integration of complex interventions. Results The model explains the normalization of complex interventions by reference to four factors demonstrated to promote or inhibit the operationalization and embedding of complex interventions (interactional workability, relational integration, skill-set workability, and contextual integration. Conclusion The model is consistent and adequate. Repeated calls for theoretically sound process evaluations in randomized controlled trials of complex interventions, and policy-makers who call for a proper understanding of implementation processes, emphasize the value of conceptual tools like the Normalization Process Model.

  3. Exergoeconomic performance optimization for a steady-flow endoreversible refrigeration model including six typical cycles

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Lingen; Kan, Xuxian; Sun, Fengrui; Wu, Feng [College of Naval Architecture and Power, Naval University of Engineering, Wuhan 430033 (China)

    2013-07-01

    The operation of a universal steady flow endoreversible refrigeration cycle model consisting of a constant thermal-capacity heating branch, two constant thermal-capacity cooling branches and two adiabatic branches is viewed as a production process with exergy as its output. The finite time exergoeconomic performance optimization of the refrigeration cycle is investigated by taking profit rate optimization criterion as the objective. The relations between the profit rate and the temperature ratio of working fluid, between the COP (coefficient of performance) and the temperature ratio of working fluid, as well as the optimal relation between profit rate and the COP of the cycle are derived. The focus of this paper is to search the compromised optimization between economics (profit rate) and the utilization factor (COP) for endoreversible refrigeration cycles, by searching the optimum COP at maximum profit, which is termed as the finite-time exergoeconomic performance bound. Moreover, performance analysis and optimization of the model are carried out in order to investigate the effect of cycle process on the performance of the cycles using numerical example. The results obtained herein include the performance characteristics of endoreversible Carnot, Diesel, Otto, Atkinson, Dual and Brayton refrigeration cycles.

  4. Exergoeconomic performance optimization for a steady-flow endoreversible refrigeration model including six typical cycles

    Directory of Open Access Journals (Sweden)

    Lingen Chen, Xuxian Kan, Fengrui Sun, Feng Wu

    2013-01-01

    Full Text Available The operation of a universal steady flow endoreversible refrigeration cycle model consisting of a constant thermal-capacity heating branch, two constant thermal-capacity cooling branches and two adiabatic branches is viewed as a production process with exergy as its output. The finite time exergoeconomic performance optimization of the refrigeration cycle is investigated by taking profit rate optimization criterion as the objective. The relations between the profit rate and the temperature ratio of working fluid, between the COP (coefficient of performance and the temperature ratio of working fluid, as well as the optimal relation between profit rate and the COP of the cycle are derived. The focus of this paper is to search the compromised optimization between economics (profit rate and the utilization factor (COP for endoreversible refrigeration cycles, by searching the optimum COP at maximum profit, which is termed as the finite-time exergoeconomic performance bound. Moreover, performance analysis and optimization of the model are carried out in order to investigate the effect of cycle process on the performance of the cycles using numerical example. The results obtained herein include the performance characteristics of endoreversible Carnot, Diesel, Otto, Atkinson, Dual and Brayton refrigeration cycles.

  5. Challenges of including nitrogen effects on decomposition in earth system models

    Science.gov (United States)

    Hobbie, S. E.

    2011-12-01

    Despite the importance of litter decomposition for ecosystem fertility and carbon balance, key uncertainties remain about how this fundamental process is affected by nitrogen (N) availability. Nevertheless, resolving such uncertainties is critical for mechanistic inclusion of such processes in earth system models, towards predicting the ecosystem consequences of increased anthropogenic reactive N. Towards that end, we have conducted a series of experiments examining nitrogen effects on litter decomposition. We found that both substrate N and externally supplied N (regardless of form) accelerated the initial decomposition rate. Faster initial decomposition rates were linked to the higher activity of carbohydrate-degrading enzymes associated with externally supplied N and the greater relative abundances of Gram negative and Gram positive bacteria associated with green leaves and externally supplied organic N (assessed using phospholipid fatty acid analysis, PLFA). By contrast, later in decomposition, externally supplied N slowed decomposition, increasing the fraction of slowly decomposing litter and reducing lignin-degrading enzyme activity and relative abundances of Gram negative and Gram positive bacteria. Our results suggest that elevated atmospheric N deposition may have contrasting effects on the dynamics of different soil carbon pools, decreasing mean residence times of active fractions comprising very fresh litter, while increasing those of more slowly decomposing fractions including more processed litter. Incorporating these contrasting effects of N on decomposition processes into models is complicated by lingering uncertainties about how these effects generalize across ecosystems and substrates.

  6. A Model for One-Dimensional Coherent Synchrotron Radiation including Short-Range Effects

    CERN Document Server

    Ryne, Robert D; Qiang, Ji; Yampolsky, Nikolai

    2012-01-01

    A new model is presented for simulating coherent synchrotron radiation (CSR) in one dimension. The method is based on convolving an integrated Green function (IGF) with the longitudinal charge density. Since it is based on an IGF, the accuracy of this approach is determined by how well one resolves the charge density and not by resolving the single particle wake function. Since short-range wakefield effects are included analytically, the approach can be much more efficient than ordinary (non-IGF) approaches in situations where the wake function and charge density have disparate spatial scales. Two cases are presented: one derived from the full wake including short-range effects, and one derived from the asymptotic wake. In the latter case the algorithm contains the same physics as others based on the asymptotic approximation, but requires only the line charge density and not its derivative. Examples are presented that illustrate the limitations of the asymptotic-wake approximation, and that illustrate how mic...

  7. INTERIOR MODELS OF SATURN: INCLUDING THE UNCERTAINTIES IN SHAPE AND ROTATION

    Energy Technology Data Exchange (ETDEWEB)

    Helled, Ravit [Department of Geophysics, Atmospheric and Planetary Sciences, Tel-Aviv University, Tel-Aviv (Israel); Guillot, Tristan [Universite de Nice-Sophia Antipolis, Observatoire de la Cote d' Azur, CNRS UMR 7293, BP 4229, F-06304 Nice (France)

    2013-04-20

    The accurate determination of Saturn's gravitational coefficients by Cassini could provide tighter constraints on Saturn's internal structure. Also, occultation measurements provide important information on the planetary shape which is often not considered in structure models. In this paper we explore how wind velocities and internal rotation affect the planetary shape and the constraints on Saturn's interior. We show that within the geodetic approach the derived physical shape is insensitive to the assumed deep rotation. Saturn's re-derived equatorial and polar radii at 100 mbar are found to be 54,445 {+-} 10 km and 60,365 {+-} 10 km, respectively. To determine Saturn's interior, we use one-dimensional three-layer hydrostatic structure models and present two approaches to include the constraints on the shape. These approaches, however, result in only small differences in Saturn's derived composition. The uncertainty in Saturn's rotation period is more significant: with Voyager's 10{sup h}39{sup m} period, the derived mass of heavy elements in the envelope is 0-7 M{sub Circled-Plus }. With a rotation period of 10{sup h}32{sup m}, this value becomes <4 M{sub Circled-Plus }, below the minimum mass inferred from spectroscopic measurements. Saturn's core mass is found to depend strongly on the pressure at which helium phase separation occurs, and is estimated to be 5-20 M{sub Circled-Plus }. Lower core masses are possible if the separation occurs deeper than 4 Mbar. We suggest that the analysis of Cassini's radio occultation measurements is crucial to test shape models and could lead to constraints on Saturn's rotation profile and departures from hydrostatic equilibrium.

  8. High performance computation of landscape genomic models including local indicators of spatial association.

    Science.gov (United States)

    Stucki, S; Orozco-terWengel, P; Forester, B R; Duruz, S; Colli, L; Masembe, C; Negrini, R; Landguth, E; Jones, M R; Bruford, M W; Taberlet, P; Joost, S

    2016-11-01

    With the increasing availability of both molecular and topo-climatic data, the main challenges facing landscape genomics - that is the combination of landscape ecology with population genomics - include processing large numbers of models and distinguishing between selection and demographic processes (e.g. population structure). Several methods address the latter, either by estimating a null model of population history or by simultaneously inferring environmental and demographic effects. Here we present samβada, an approach designed to study signatures of local adaptation, with special emphasis on high performance computing of large-scale genetic and environmental data sets. samβada identifies candidate loci using genotype-environment associations while also incorporating multivariate analyses to assess the effect of many environmental predictor variables. This enables the inclusion of explanatory variables representing population structure into the models to lower the occurrences of spurious genotype-environment associations. In addition, samβada calculates local indicators of spatial association for candidate loci to provide information on whether similar genotypes tend to cluster in space, which constitutes a useful indication of the possible kinship between individuals. To test the usefulness of this approach, we carried out a simulation study and analysed a data set from Ugandan cattle to detect signatures of local adaptation with samβada, bayenv, lfmm and an FST outlier method (FDIST approach in arlequin) and compare their results. samβada - an open source software for Windows, Linux and Mac OS X available at http://lasig.epfl.ch/sambada - outperforms other approaches and better suits whole-genome sequence data processing.

  9. Including oxygen enhancement ratio in ion beam treatment planning: model implementation and experimental verification

    Science.gov (United States)

    Scifoni, E.; Tinganelli, W.; Weyrather, W. K.; Durante, M.; Maier, A.; Krämer, M.

    2013-06-01

    We present a method for adapting a biologically optimized treatment planning for particle beams to a spatially inhomogeneous tumor sensitivity due to hypoxia, and detected e.g., by PET functional imaging. The TRiP98 code, established treatment planning system for particles, has been extended for including explicitly the oxygen enhancement ratio (OER) in the biological effect calculation, providing the first set up of a dedicated ion beam treatment planning approach directed to hypoxic tumors, TRiP-OER, here reported together with experimental tests. A simple semi-empirical model for calculating the OER as a function of oxygen concentration and dose averaged linear energy transfer, generating input tables for the program is introduced. The code is then extended in order to import such tables coming from the present or alternative models, accordingly and to perform forward and inverse planning, i.e., predicting the survival response of differently oxygenated areas as well as optimizing the required dose for restoring a uniform survival effect in the whole irradiated target. The multiple field optimization results show how the program selects the best beam components for treating the hypoxic regions. The calculations performed for different ions, provide indications for the possible clinical advantages of a multi-ion treatment. Finally the predictivity of the code is tested through dedicated cell culture experiments on extended targets irradiation using specially designed hypoxic chambers, providing a qualitative agreement, despite some limits in full survival calculations arising from the RBE assessment. The comparison of the predictions resulting by using different model tables are also reported.

  10. THE SUPERIORITY OF EMPIRICAL BAYES ESTIMATION OF PARAMETERS IN PARTITIONED NORMAL LINEAR MODEL

    Institute of Scientific and Technical Information of China (English)

    Zhang Weiping; Wei Laisheng

    2008-01-01

    In this article, the empirical Bayes (EB) estimators are constructed for the estimable functions of the parameters in partitioned normal linear model. The superiorities of the EB estimators over ordinary least-squares (LS) estimator are investigated under mean square error matrix (MSEM) criterion.

  11. TESTING SPHERICITY IN A GMANOVA-MANOVA MODEL WITH NORMAL ERROR

    Institute of Scientific and Technical Information of China (English)

    Bai Peng; Shi Lei

    2008-01-01

    This article presents a statistic for testing the sphericity in a GMANOVA-MANOVA model with normal error. It is shown that the null distribution of this statistic is beta and its nonnull distribution is given in series form of beta distributions.

  12. Modeling speech intelligibility in quiet and noise in listeners with normal and impaired hearing

    NARCIS (Netherlands)

    K.S. Rhebergen; J. Lyzenga; W.A. Dreschler; J.M. Festen

    2010-01-01

    The speech intelligibility index (SII) is an often used calculation method for estimating the proportion of audible speech in noise. For speech reception thresholds (SRTs), measured in normally hearing listeners using various types of stationary noise, this model predicts a fairly constant speech pr

  13. ON ASYMPTOTIC NORMALITY OF PARAMETERS IN MULTIPLE LINEAR ERRORS-IN-VARIABLES MODEL

    Institute of Scientific and Technical Information of China (English)

    ZHANG Sanguo; CHEN Xiru

    2003-01-01

    This paper studies the parameter estimation of multiple dimensional linear errors-in-variables (EV) models in the case where replicated observations are available in some experimental points. Asymptotic normality is established under mild conditions, and the parameters entering the asymptotic variance are consistently estimated to render the result useable in the construction of large-sample confidence regions.

  14. Development and Implementation of Mechanistic Terry Turbine Models in RELAP-7 to Simulate RCIC Normal Operation Conditions

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Haihua [Idaho National Lab. (INL), Idaho Falls, ID (United States); Zou, Ling [Idaho National Lab. (INL), Idaho Falls, ID (United States); Zhang, Hongbin [Idaho National Lab. (INL), Idaho Falls, ID (United States); O' Brien, James Edward [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-09-01

    As part of the efforts to understand the unexpected “self-regulating” mode of the RCIC (Reactor Core Isolation Cooling) systems in Fukushima accidents and extend BWR RCIC and PWR AFW (Auxiliary Feed Water) operational range and flexibility, mechanistic models for the Terry turbine, based on Sandia’s original work [1], have been developed and implemented in the RELAP-7 code to simulate the RCIC system. In 2016, our effort has been focused on normal working conditions of the RCIC system. More complex off-design conditions will be pursued in later years when more data are available. In the Sandia model, the turbine stator inlet velocity is provided according to a reduced-order model which was obtained from a large number of CFD (computational fluid dynamics) simulations. In this work, we propose an alternative method, using an under-expanded jet model to obtain the velocity and thermodynamic conditions for the turbine stator inlet. The models include both an adiabatic expansion process inside the nozzle and a free expansion process outside of the nozzle to ambient pressure. The combined models are able to predict the steam mass flow rate and supersonic velocity to the Terry turbine bucket entrance, which are the necessary input information for the Terry turbine rotor model. The analytical models for the nozzle were validated with experimental data and benchmarked with CFD simulations. The analytical models generally agree well with the experimental data and CFD simulations. The analytical models are suitable for implementation into a reactor system analysis code or severe accident code as part of mechanistic and dynamical models to understand the RCIC behaviors. The newly developed nozzle models and modified turbine rotor model according to the Sandia’s original work have been implemented into RELAP-7, along with the original Sandia Terry turbine model. A new pump model has also been developed and implemented to couple with the Terry turbine model. An input

  15. Model of fracture for the Zry cladding of nuclear fuel rods included in the code DIONISIO 1.0

    Energy Technology Data Exchange (ETDEWEB)

    Soba, Alejandro [Departamento Combustibles Nucleares, Comision Nacional de Energia Atomica, Av. del Libertador 8250, 1429 Buenos Aires (Argentina)], E-mail: soba@cnea.gov.ar; Denis, Alicia [Departamento Combustibles Nucleares, Comision Nacional de Energia Atomica, Av. del Libertador 8250, 1429 Buenos Aires (Argentina)], E-mail: denis@cnea.gov.ar

    2008-12-15

    The DIONISIO code describes most of the main phenomena occurring in a fuel rod during normal operation of a nuclear power reactor. Starting from the irradiation history, the code predicts the temperature distribution, elastic and plastic stress and strain, creep, swelling and densification, release of fission gases, caesium and iodine to the internal rod volume, gas mixing, pressure increase, irradiation growth of the cladding, development of an oxide layer on its surface and hydrogen uptake, restructuring and grain growth in the pellet. This work presents the model of Zircaloy fracture included in the code DIONISIO 1.0. The model of pellet-cladding mechanical interaction (PCMI) provides the forces caused by the solid-solid contact which add to the changing internal pressure and to the constant external pressure. Besides, the program evaluates the effects of a corrosive atmosphere (stress corrosion cracking, SCC) internal or external. With these data, the code calculates the J integral around the tip of an initiated crack, and proceeds to analyze, according to the quantity of corrosive substance dissolved and the cladding stress field, if the crack remains unchanged, if it grows due to the I-SCC mechanism, or if propagation is ductile, following the R curve of the material. Results corresponding to different PHWR and PWR reactors are presented and compared with code results. In particular, good agreement is obtained in the simulation of MOX experiments, where the cladding failed due to propagation of cracks originated in SCC.

  16. Genetic Analysis of Somatic Cell Score in Danish Holsteins Using a Liability-Normal Mixture Model

    DEFF Research Database (Denmark)

    Madsen, P; Shariati, M M; Ødegård, J

    2008-01-01

    Mixture models are appealing for identifying hidden structures affecting somatic cell score (SCS) data, such as unrecorded cases of subclinical mastitis. Thus, liability-normal mixture (LNM) models were used for genetic analysis of SCS data, with the aim of predicting breeding values for such cas...... categorizing only the most extreme SCS observations as mastitic, and such cases of subclinical infections may be the most closely related to clinical (treated) mastitis...

  17. Auditory normalization of French vowels synthesized by an articulatory model simulating growth from birth to adulthood

    Science.gov (United States)

    Ménard, Lucie; Schwartz, Jean-Luc; Boë, Louis-Jean; Kandel, Sonia; Vallée, Nathalie

    2002-04-01

    The present article aims at exploring the invariant parameters involved in the perceptual normalization of French vowels. A set of 490 stimuli, including the ten French vowels eye, why, you, ee, ø oh, eh, oelig, openo, aye produced by an articulatory model, simulating seven growth stages and seven fundamental frequency values, has been submitted as a perceptual identification test to 43 subjects. The results confirm the important effect of the tonality distance between F1 and f0 in perceived height. It does not seem, however, that height perception involves a binary organization determined by the 3-3.5-Bark critical distance. Regarding place of articulation, the tonotopic distance between F1 and F2 appears to be the best predictor of the perceived front-back dimension. Nevertheless, the role of the difference between F2 and F3 remains important. Roundedness is also examined and correlated to the effective second formant, involving spectral integration of higher formants within the 3.5-Bark critical distance. The results shed light on the issue of perceptual invariance, and can be interpreted as perceptual constraints imposed on speech production.

  18. Modeling the Normal Spectral Emissivity of Aluminum 1060 at 800-910 K During the Growth of Oxide Layer

    Science.gov (United States)

    Shi, Deheng; Zou, Fenghui; Zhu, Zunlue; Sun, Jinfeng

    2015-04-01

    This work strives to model the normal spectral emissivity of aluminum 1060 during the growth of oxide layer in air over the temperatures ranging from 800 to 910 K. For this reason, the normal spectral emissivity of aluminum 1060 has been measured over a 6 h heating period at a definite temperature. In our experiment, the radiance coming from the specimen is received by an InGaAs photodiode detector, which works at 1.5 μm with the bandwidth of 20 nm. The temperature of specimen surface is measured by averaging the two platinum-rhodium thermocouples, which are symmetrically welded in the front surface of specimen near the measuring area viewed by the detector. The strong oscillations of normal spectral emissivity have been observed and discussed, which are affirmed to be connected with the thickness of oxide layer on the specimen surface, and originate from the interference effect between the radiation coming from the oxide layer on the specimen surface and the radiation stemming from the substrate. The uncertainty of normal spectral emissivity contributed only by the surface oxidization is about 4.6-10.6%, and the corresponding uncertainty of temperature contributed only by the surface oxidization is about 3.5-8.4 K. The analytical model between the normal spectral emissivity and the heating time is evaluated at a definite temperature. A simple functional form with the exponential and logarithmic functions can be employed to reproduce well the variation of normal spectral emissivity with the heating time at a definite temperature, including the reproduction of strong oscillations.

  19. Modeled current distribution inside the normal and malignant human urothelium using finite element analysis.

    Science.gov (United States)

    Keshtkar, Ahmad; Keshtkar, Asghar

    2008-02-01

    When the tissue is changing from normal to abnormal, the distribution of tissue liquids between intra and extra cellular space will be changed and then the measured conductivity and impedivity will also be changed. Therefore, it will cause a different current distribution inside the human bladder tissue in normal and malignant cases. By knowing the amount of electrical impedance inside the bladder tissue and the morphological parameters of the different layers of this tissue, the current distribution inside the bladder tissue (surface fluid, superficial urothelium, intermediate urothelium, basal urothelium, basement membrane, and connective tissue) was modelled and calculated in different frequencies using the finite element analysis. The model results showed that very little of the current actually flows through the urothelium and much of the injected current flows through the connective tissue beneath the urothelium (in normal cases). However, most of the current flows through the surface fluid in the low frequency range in normal tissue. Furthermore, for the high frequencies, the tight junctions are short-circuited, so the current penetrates deeper, flowing through the connective tissue beneath the urothelium, while, in the malignant cases, at least 50% of the injected current flows beneath transformed urothelium across the frequency range modelled.

  20. Computer modelling of bone's adaptation: the role of normal strain, shear strain and fluid flow.

    Science.gov (United States)

    Tiwari, Abhishek Kumar; Prasad, Jitendra

    2017-04-01

    Bone loss is a serious health problem. In vivo studies have found that mechanical stimulation may inhibit bone loss as elevated strain in bone induces osteogenesis, i.e. new bone formation. However, the exact relationship between mechanical environment and osteogenesis is less clear. Normal strain is considered as a prime stimulus of osteogenic activity; however, there are some instances in the literature where osteogenesis is observed in the vicinity of minimal normal strain, specifically near the neutral axis of bending in long bones. It suggests that osteogenesis may also be induced by other or secondary components of mechanical environment such as shear strain or canalicular fluid flow. As it is evident from the literature, shear strain and fluid flow can be potent stimuli of osteogenesis. This study presents a computational model to investigate the roles of these stimuli in bone adaptation. The model assumes that bone formation rate is roughly proportional to the normal, shear and fluid shear strain energy density above their osteogenic thresholds. In vivo osteogenesis due to cyclic cantilever bending of a murine tibia has been simulated. The model predicts results close to experimental findings when normal strain, and shear strain or fluid shear were combined. This study also gives a new perspective on the relation between osteogenic potential of micro-level fluid shear and that of macro-level bending shear. Attempts to establish such relations among the components of mechanical environment and corresponding osteogenesis may ultimately aid in the development of effective approaches to mitigating bone loss.

  1. The closures of (U+K)-orbits of essentially normal triangular operator models

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The (U + K)-orbit of a bounded linear operator T acting on a Hilbert space H is defined as (U + K)(T)={R-1 T R:R is invertible of the form unitary plus compact on H}.In this paper,we first characterize the closure of the (U + K)-orbit of an essentially normal triangular operator T satisfying H={ker(T-λI):λ∈ρ F (T)} and σ p (T*)=ф.After that,we establish certain essentially normal triangular operator models with the form of the direct sums of triangular operators,adjoint of triangular operators and normal operators,show that such operator models generate the same closed (U + K)-orbit if they have the same spectral picture,and describe the closures of the (U + K)-orbits of these operator models.These generalize some known results on the closures of (U + K)-orbits of essentially normal operators,and provide more positive cases to an open conjecture raised by Marcoux as Question 2 in his article "A survey of (U + K)-orbits".

  2. Consistency and asymptotic normality of profile-kernel and backfitting estimators in semiparametric reproductive dispersion nonlinear models

    Institute of Scientific and Technical Information of China (English)

    TANG NianSheng; CHEN XueDong; WANG XueRen

    2009-01-01

    Semiparametric reproductive dispersion nonlinear model (SRDNM) is an extension of nonlinear reproductive dispersion models and semiparametric nonlinear regression models, and includes semiparametric nonlinear model and semiparametric generalized linear model as its special cases. Based on the local kernel estimate of nonparametric component, profile-kernel and backfitting estimators of parameters of interest are proposed in SRDNM, and theoretical comparison of both estimators is also investigated in this paper. Under some regularity conditions, strong consistency and asymptotic normality of two estimators are proved. It is shown that the backtitting method produces a larger asymptotic variance than that for the profile-kernel method. A simulation study and a real example are used to illustrate the proposed methodologies.

  3. Comparative study on different models for estimation of direct normal irradiance (DNI) over Egypt atmosphere

    Energy Technology Data Exchange (ETDEWEB)

    Madkour, M.A.; Hamed, A.B. [Physics Department, Faculty of Science, Mansoura University (Egypt); El-Metwally, M. [Physics Department, Faculty of Education at Suez, Suez Canal University, Suez (Egypt)

    2006-03-01

    The results obtained by using seven-parameterization broadband models to estimate Direct Normal Irradiance (DNI) along with two spectral models for four sites in Egypt atmosphere were compared with ground DNI measurements. Some statistical indicators (MBE, RMSE and R{sup 2}) have been used to measure the performance of the used models. MBE for all dataset is <1% to both spectral models (SPCTRAL2, SMARTS2) and broadband models (MLWT1, MLWT2 and REST) while is equal to 1.2% to YANG model. However, RMSE are around 2% for spectral models and 3% to the broadband models. The error in prediction of DNI to such models is below experimental errors a part from the big number of observations. On the other hand, Louche, Dogniaux and Rodgers models provide relatively bad performance, RMSE are at most cases >4%. Determination coefficient (R{sup 2}) results to all models are near 1.0. If we excluded spectral models, the broadband models MLWT1, MLWT2 and REST along with YANG models provide the best performance in all tests, therefore, those models can be used in Egypt atmosphere. (author)

  4. Beer's-law-based, simple spectral model for direct normal and diffuse horizontal irradiance

    Energy Technology Data Exchange (ETDEWEB)

    Bird, R.E.

    1982-12-01

    A spectral model for cloudless days that uses simple mathematical expressions and tabulated look-up tables to generate direct normal and diffuse horizontal irradiance is presented. The model is based on modifications to previously published simple models and comparisons with rigorous radiative transfer codes. This model is expected to be more accurate and to be applicable to a broader range of atmospheric conditions than previous simple models. The prime significance of this model is its simplicity, which allows it to be used on small desk-top computers. The spctrum produced by this model is limited to 0.3 to 4.0 ..mu..m wavelength with an approximate resolution of 10 nm.

  5. Mathematical and numerical model of directional solidification including initial and terminal transients of the process

    Directory of Open Access Journals (Sweden)

    W. Kapturkiewicz

    2008-12-01

    Full Text Available The, developed in this study, simple model and numerical solution of diffusion growth of the solid phase under the conditions of directional solidification allow for the effect of constituent diffusion in both liquid and solid phase and assume the process run in which (like in reality the preset parameter is the velocity of sample (pulling velocity at a preset temperature gradient. The solid/liquid interface velocity is not the process parameter (like it is in numerous other solutions proposed so far but a function of this process. The effect of convection outside the diffusion layer has been included in mass balance under the assumption that in the zone of convection the mixing is complete. The above assumptions enabled solving the kinetics of growth of the solid phase (along with the diffusion field in solid and liquid phase under the conditions of diffusion well reflecting the process run starting with the initial transient state, going through the steady state period in central part of the casting, and ending in a terminal transient state. In the numerical solution obtained by the finite difference method with variable grid dimensions, the error of the mass control balance over the whole process range was 1 - 2 %.

  6. Combined thermal and elastic modeling of the normal and tumorous breast

    Science.gov (United States)

    Jiang, Li; Zhan, Wang; Loew, Murray

    2008-03-01

    The abnormal thermogram has been shown to be a reliable indicator of a high risk of breast cancer, but an open question is how to quantify the complex relationships between the breast thermal behaviors and the underlying physiological/pathological conditions. Previous thermal modeling techniques generally did not utilize the breast geometry determined by the gravity-induced elastic deformations arising from various body postures. In this paper, a 3-D finite-element method is developed for combined modeling of the thermal and elastic properties of the breast, including the mechanical nonlinearity associated with large deformations. The effects of the thermal and elastic properties of the breast tissues are investigated quantitatively. For the normal breast in a standing/sitting up posture, the gravity-induced deformation alone is found to be able to cause an asymmetric temperature distribution even though all the thermal/elastic properties are symmetrical, and this temperature asymmetry increases for softer and more compressible breast tissues. For a tumorous breast, we found that the surface-temperature alterations generally can be recognizable for superficial tumors at depths less than 20 mm. Tumor size plays a less important role than the tumor depth in determining the tumor-induced temperature difference. This result may imply that a higher thermal sensitivity is critical for a breast thermogram system when deeper tumors are present, even if the tumor is relatively large. We expect this new method to provide a stronger foundation for, and greater specificity and precision in, thermographic diagnosis and treatment of breast tumors.

  7. Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model.

    Science.gov (United States)

    Lee, Jeong-Hyun; Kim, Hye-Lee; Lee, Mi Hee; You, Kyung Eun; Kwon, Byeong-Ju; Seo, Hyok Jin; Park, Jong-Chul

    2012-10-15

    Wound healing proceeds through a complex collaborative process involving many types of cells. Keratinocytes and fibroblasts of epidermal and dermal layers of the skin play prominent roles in this process. Asiaticoside, an active component of Centella asiatica, is known for beneficial effects on keloid and hypertrophic scar. However, the effects of this compound on normal human skin cells are not well known. Using in vitro systems, we observed the effects of asiaticoside on normal human skin cell behaviors related to healing. In a wound closure seeding model, asiaticoside increased migration rates of skin cells. By observing the numbers of cells attached and the area occupied by the cells, we concluded that asiaticoside also enhanced the initial skin cell adhesion. In cell proliferation assays, asiaticoside induced an increase in the number of normal human dermal fibroblasts. In conclusion, asiaticoside promotes skin cell behaviors involved in wound healing; and as a bioactive component of an artificial skin, may have therapeutic value.

  8. Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model.

    Science.gov (United States)

    Schaette, Roland; McAlpine, David

    2011-09-21

    Ever since Pliny the Elder coined the term tinnitus, the perception of sound in the absence of an external sound source has remained enigmatic. Traditional theories assume that tinnitus is triggered by cochlear damage, but many tinnitus patients present with a normal audiogram, i.e., with no direct signs of cochlear damage. Here, we report that in human subjects with tinnitus and a normal audiogram, auditory brainstem responses show a significantly reduced amplitude of the wave I potential (generated by primary auditory nerve fibers) but normal amplitudes of the more centrally generated wave V. This provides direct physiological evidence of "hidden hearing loss" that manifests as reduced neural output from the cochlea, and consequent renormalization of neuronal response magnitude within the brainstem. Employing an established computational model, we demonstrate how tinnitus could arise from a homeostatic response of neurons in the central auditory system to reduced auditory nerve input in the absence of elevated hearing thresholds.

  9. An analytic model for acoustic scattering from an impedance cylinder placed normal to an impedance plane

    Science.gov (United States)

    Swearingen, Michelle Elaine

    2003-10-01

    This thesis is a presentation of an analytic model, developed in cylindrical coordinates, for the scattering of a spherical wave off a semi infinite right cylinder placed normal to a ground surface. The model is developed to simulate a single tree and is developed as a first piece to creating a model for estimating attenuation in a forest based on scattering from individual tree trunks. Comparisons are made to the plane wave case, the transparent cylinder case, and the rigid and soft ground cases as a method of theoretically verifying the model. Agreement is excellent for these benchmark cases. Model sensitivity to five parameters is determined, which aids in error analysis, particularly when comparing the model results to experimental data, and offers insight into the inner workings of the model. An experiment was performed to collect real-world data on scattering from a cylinder normal to a ground surface. The data from the experiment is analyzed with a transfer function method into frequency and impulse responses. The model results are compared to the experimental data.

  10. SmEdA vibro-acoustic modelling in the mid-frequency range including the effect of dissipative treatments

    Science.gov (United States)

    Hwang, H. D.; Maxit, L.; Ege, K.; Gerges, Y.; Guyader, J.-L.

    2017-04-01

    Vibro-acoustic simulation in the mid-frequency range is of interest for automotive and truck constructors. The dissipative treatments used for noise and vibration control such as viscoelastic patches and acoustic absorbing materials must be taken into account in the problem. The Statistical modal Energy distribution Analysis (SmEdA) model consists in extending Statistical Energy Analysis (SEA) to the mid-frequency range by establishing power balance equations between the modes of the different subsystems. The modal basis of uncoupled-subsystems that can be estimated by the finite element method in the mid-frequency range is used as input data. SmEdA was originally developed by considering constant modal damping factors for each subsystem. However, this means that it cannot describe the local distribution of dissipative materials. To overcome this issue, a methodology is proposed here to take into account the effect of these materials. This methodology is based on the finite element models of the subsystems that include well-known homogenized material models of dissipative treatments. The Galerkin method with subsystem normal modes is used to estimate the modal damping loss factors. Cross-modal coupling terms which appear in the formulation due to the dissipative materials are assumed to be negligible. An approximation of the energy sharing between the subsystems damped by dissipative materials is then described by SmEdA. The different steps of the method are validated experimentally by applying it to a laboratory test case composed of a plate-cavity system with different configurations of dissipative treatments. The comparison between the experimental and the simulation results shows good agreement in the mid-frequency range.

  11. Modelling anaerobic digestion in an industrial biogas digester: Application of lactate-including ADM1 model (Part II).

    Science.gov (United States)

    Satpathy, Preseela; Biernacki, Piotr; Cypionka, Heribert; Steinigeweg, Sven

    2016-12-05

    A modified Anaerobic Digestion Model No. 1 (ADM1xp) including lactate was applied to a full-scale biogas plant. This model considers monosaccharides to degrade through lactic acid, which further degrades majorly into acetate followed by propionate and butyrate. Experimental data were derived from the previous works in the same laboratory, and the proposed parameters were validated against batch experiments. After successful validation, the biogas plant bearing a fermenter size of 7 dam(3) and operated with food waste and cattle manure was simulated. The biogas production and methane content were reliably simulated, and a good fit could be obtained against the experimental data with an average difference of less than 1%. When compared to the original ADM1 model, the performance of the lactate-incorporated model was found to be improved. Inclusion of lactate as a parameter in the ADM1xp model is recommended for an increased sensitivity and enhanced prediction principally for systems dealing with high carbohydrate and lactate loads.

  12. Numerical modelling of seawater intrusion in Shenzhen (China) using a 3D densitydependent model including tidal effects

    Indian Academy of Sciences (India)

    Wei Lu; Qingchun Yang; Jordi D Martín; Ricardo Juncosa

    2013-04-01

    During the 1990s, groundwater overexploitation has resulted in seawater intrusion in the coastal aquifer of the Shenzhen city, China. Although water supply facilities have been improved and alleviated seawater intrusion in recent years, groundwater overexploitation is still of great concern in some local areas. In this work we present a three-dimensional density-dependent numerical model developed with the FEFLOW code, which is aimed at simulating the extent of seawater intrusion while including tidal effects and different groundwater pumping scenarios. Model calibration, using waterheads and reported chloride concentration, has been performed based on the data from 14 boreholes, which were monitored from May 2008 to December 2009. A fairly good fitness between the observed and computed values was obtained by a manual trial-and-error method. Model prediction has been carried out forward 3 years with the calibrated model taking into account high, medium and low tide levels and different groundwater exploitation schemes. The model results show that tide-induced seawater intrusion significantly affects the groundwater levels and concentrations near the estuarine of the Dasha river, which implies that an important hydraulic connection exists between this river and groundwater, even considering that some anti-seepage measures were taken in the river bed. Two pumping scenarios were considered in the calibrated model in order to predict the future changes in the water levels and chloride concentration. The numerical results reveal a decreased tendency of seawater intrusion if groundwater exploitation does not reach an upper bound of about 1.32 × 104 m3/d. The model results provide also insights for controlling seawater intrusion in such coastal aquifer systems.

  13. Wind turbine condition monitoring based on SCADA data using normal behavior models

    DEFF Research Database (Denmark)

    Schlechtingen, Meik; Santos, Ilmar; Achiche, Sofiane

    2013-01-01

    This paper proposes a system for wind turbine condition monitoring using Adaptive Neuro-Fuzzy Interference Systems (ANFIS). For this purpose: (1) ANFIS normal behavior models for common Supervisory Control And Data Acquisition (SCADA) data are developed in order to detect abnormal behavior....... The applicability of the set up ANFIS models for anomaly detection is proved by the achieved performance of the models. In combination with the FIS the prediction errors can provide information about the condition of the monitored components. In this paper the condition monitoring system is described. Part two...... the applicability of ANFIS models for monitoring wind turbine SCADA signals. The computational time needed for model training is compared to Neural Network (NN) models showing the strength of ANFIS in training speed. (2) For automation of fault diagnosis Fuzzy Interference Systems (FIS) are used to analyze...

  14. Impact of statistical learning methods on the predictive power of multivariate normal tissue complication probability models.

    Science.gov (United States)

    Xu, Cheng-Jian; van der Schaaf, Arjen; Schilstra, Cornelis; Langendijk, Johannes A; van't Veld, Aart A

    2012-03-15

    To study the impact of different statistical learning methods on the prediction performance of multivariate normal tissue complication probability (NTCP) models. In this study, three learning methods, stepwise selection, least absolute shrinkage and selection operator (LASSO), and Bayesian model averaging (BMA), were used to build NTCP models of xerostomia following radiotherapy treatment for head and neck cancer. Performance of each learning method was evaluated by a repeated cross-validation scheme in order to obtain a fair comparison among methods. It was found that the LASSO and BMA methods produced models with significantly better predictive power than that of the stepwise selection method. Furthermore, the LASSO method yields an easily interpretable model as the stepwise method does, in contrast to the less intuitive BMA method. The commonly used stepwise selection method, which is simple to execute, may be insufficient for NTCP modeling. The LASSO method is recommended. Copyright © 2012 Elsevier Inc. All rights reserved.

  15. Normality Index of Ventricular Contraction Based on a Statistical Model from FADS

    Science.gov (United States)

    Jiménez-Ángeles, Luis; Valdés-Cristerna, Raquel; Vallejo, Enrique; Bialostozky, David; Medina-Bañuelos, Verónica

    2013-01-01

    Radionuclide-based imaging is an alternative to evaluate ventricular function and synchrony and may be used as a tool for the identification of patients that could benefit from cardiac resynchronization therapy (CRT). In a previous work, we used Factor Analysis of Dynamic Structures (FADS) to analyze the contribution and spatial distribution of the 3 most significant factors (3-MSF) present in a dynamic series of equilibrium radionuclide angiography images. In this work, a probability density function model of the 3-MSF extracted from FADS for a control group is presented; also an index, based on the likelihood between the control group's contraction model and a sample of normal subjects is proposed. This normality index was compared with those computed for two cardiopathic populations, satisfying the clinical criteria to be considered as candidates for a CRT. The proposed normality index provides a measure, consistent with the phase analysis currently used in clinical environment, sensitive enough to show contraction differences between normal and abnormal groups, which suggests that it can be related to the degree of severity in the ventricular contraction dyssynchrony, and therefore shows promise as a follow-up procedure for patients under CRT. PMID:23634177

  16. Normality Index of Ventricular Contraction Based on a Statistical Model from FADS

    Directory of Open Access Journals (Sweden)

    Luis Jiménez-Ángeles

    2013-01-01

    Full Text Available Radionuclide-based imaging is an alternative to evaluate ventricular function and synchrony and may be used as a tool for the identification of patients that could benefit from cardiac resynchronization therapy (CRT. In a previous work, we used Factor Analysis of Dynamic Structures (FADS to analyze the contribution and spatial distribution of the 3 most significant factors (3-MSF present in a dynamic series of equilibrium radionuclide angiography images. In this work, a probability density function model of the 3-MSF extracted from FADS for a control group is presented; also an index, based on the likelihood between the control group's contraction model and a sample of normal subjects is proposed. This normality index was compared with those computed for two cardiopathic populations, satisfying the clinical criteria to be considered as candidates for a CRT. The proposed normality index provides a measure, consistent with the phase analysis currently used in clinical environment, sensitive enough to show contraction differences between normal and abnormal groups, which suggests that it can be related to the degree of severity in the ventricular contraction dyssynchrony, and therefore shows promise as a follow-up procedure for patients under CRT.

  17. ETM documentation update – including modelling conventions and manual for software tools

    DEFF Research Database (Denmark)

    Grohnheit, Poul Erik

    , it summarises the work done during 2013, and it also contains presentations for promotion of fusion as a future element in the electricity generation mix and presentations for the modelling community concerning model development and model documentation – in particular for TIAM collaboration workshops....

  18. Modelling stress-dependent permeability in fractured rock including effects of propagating and bending fractures

    NARCIS (Netherlands)

    Latham, J.P.; Xiang, J.; Belayneh, M.; Nick, H.M.; Tsang, C.F.; Blunt, M.J.

    2013-01-01

    The influence of in-situ stresses on flow processes in fractured rock is investigated using a novel modelling approach. The combined finite-discrete element method (FEMDEM) is used to model the deformation of a fractured rock mass. The fracture wall displacements and aperture changes are modelled in

  19. A sub-circuit MOSFET model with a wide temperature range including cryogenic temperature*

    Institute of Scientific and Technical Information of China (English)

    Jia Kan; Sun Weifeng; Shi Longxing

    2011-01-01

    A sub-circuit SPICE model ofa MOSFET for low temperature operation is presented. Two resistors are introduced for the freeze-out effect, and the explicit behavioral models are developed for them. The model can be used in a wide temperature range covering both cryogenic temperature and regular temperatures.

  20. Including Overweight or Obese Students in Physical Education: A Social Ecological Constraint Model

    Science.gov (United States)

    Li, Weidong; Rukavina, Paul

    2012-01-01

    In this review, we propose a social ecological constraint model to study inclusion of overweight or obese students in physical education by integrating key concepts and assumptions from ecological constraint theory in motor development and social ecological models in health promotion and behavior. The social ecological constraint model proposes…

  1. A methodology for including wall roughness effects in k-ε low-Reynolds turbulence models

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosini, W., E-mail: walter.ambrosini@ing.unipi.it; Pucciarelli, A.; Borroni, I.

    2015-05-15

    Highlights: • A model for taking into account wall roughness in low-Reynolds k-ε models is presented. • The model is subjected to a first validation to show its potential in general applications. • The application of the model in predicting heat transfer to supercritical fluids is also discussed. - Abstract: A model accounting for wall roughness effects in k-ε low-Reynolds turbulence models is described in the present paper. In particular, the introduction in the transport equations of k and ε of additional source terms related to roughness, based on simple assumptions and dimensional relationships, is proposed. An objective of the present paper, in addition to obtaining more realistic predictions of wall friction, is the application of the proposed model to the study of heat transfer to supercritical fluids. A first validation of the model is reported. The model shows the capability of predicting, at least qualitatively, some of the most important trends observed when dealing with rough pipes in very different flow conditions. Qualitative comparisons with some DNS data available in literature are also performed. Further analyses provided promising results concerning the ability of the model in reproducing the trend of friction factor when varying the flow conditions, though improvements are necessary for achieving better quantitative accuracy. First applications of the model in simulating heat transfer to supercritical fluids are also described, showing the capability of the model to affect the predictions of these heat transfer phenomena, in particular in the vicinity of the pseudo-critical conditions. A more extended application of the model to relevant deteriorated heat transfer conditions will clarify the usefulness of this modelling methodology in improving predictions of these difficult phenomena. Whatever the possible success in this particular application that motivated its development, this approach suggests a general methodology for accounting

  2. Inflammatory Cytokine Tumor Necrosis Factor α Confers Precancerous Phenotype in an Organoid Model of Normal Human Ovarian Surface Epithelial Cells

    Directory of Open Access Journals (Sweden)

    Joseph Kwong

    2009-06-01

    Full Text Available In this study, we established an in vitro organoid model of normal human ovarian surface epithelial (HOSE cells. The spheroids of these normal HOSE cells resembled epithelial inclusion cysts in human ovarian cortex, which are the cells of origin of ovarian epithelial tumor. Because there are strong correlations between chronic inflammation and the incidence of ovarian cancer, we used the organoid model to test whether protumor inflammatory cytokine tumor necrosis factor α would induce malignant phenotype in normal HOSE cells. Prolonged treatment of tumor necrosis factor α induced phenotypic changes of the HOSE spheroids, which exhibited the characteristics of precancerous lesions of ovarian epithelial tumors, including reinitiation of cell proliferation, structural disorganization, epithelial stratification, loss of epithelial polarity, degradation of basement membrane, cell invasion, and overexpression of ovarian cancer markers. The result of this study provides not only an evidence supporting the link between chronic inflammation and ovarian cancer formation but also a relevant and novel in vitro model for studying of early events of ovarian cancer.

  3. Comparison of some biased estimation methods (including ordinary subset regression) in the linear model

    Science.gov (United States)

    Sidik, S. M.

    1975-01-01

    Ridge, Marquardt's generalized inverse, shrunken, and principal components estimators are discussed in terms of the objectives of point estimation of parameters, estimation of the predictive regression function, and hypothesis testing. It is found that as the normal equations approach singularity, more consideration must be given to estimable functions of the parameters as opposed to estimation of the full parameter vector; that biased estimators all introduce constraints on the parameter space; that adoption of mean squared error as a criterion of goodness should be independent of the degree of singularity; and that ordinary least-squares subset regression is the best overall method.

  4. Normal Vector Projection Method used for Convex Optimization of Chan-Vese Model for Image Segmentation

    Science.gov (United States)

    Wei, W. B.; Tan, L.; Jia, M. Q.; Pan, Z. K.

    2017-01-01

    The variational level set method is one of the main methods of image segmentation. Due to signed distance functions as level sets have to keep the nature of the functions through numerical remedy or additional technology in an evolutionary process, it is not very efficient. In this paper, a normal vector projection method for image segmentation using Chan-Vese model is proposed. An equivalent formulation of Chan-Vese model is used by taking advantage of property of binary level set functions and combining with the concept of convex relaxation. Threshold method and projection formula are applied in the implementation. It can avoid the above problems and obtain a global optimal solution. Experimental results on both synthetic and real images validate the effects of the proposed normal vector projection method, and show advantages over traditional algorithms in terms of computational efficiency.

  5. Renormalization of spin polarized itinerant electron bands in the normal state of a model ferromagnetic superconductor

    Institute of Scientific and Technical Information of China (English)

    Ma Lei; Huang Ai-Qun; Li Jun

    2011-01-01

    This paper studies the normal state properties of itinerant electrons in a toy model, which is constructed according to the model for coexisting ferromagnetism and superconductivity proposed by Suhl [Suhl H 2001 Phys. Rev. Lett. 87 167007]. In this theory with ferromagnetic ordering based on localized spins, the exchange interaction J between conduction electrons and localized spin is taken as the pairing glue for s-wave superconductivity. It shows that this J term will first renormalize the normal state single conduction electron structures substantially. It finds dramatically enhanced or suppressed magnetization of itinerant electrons for positive or negative J. Singlet Cooper pairing can be ruled out due to strong spin polarisation in the J > 0 case while a narrow window for s-wave superconductivity is opened around some ferromagnetic J.

  6. Modeling of Normal Perforation of Reinforced Concrete Slabs by a Rigid Projectile

    Institute of Scientific and Technical Information of China (English)

    CHEN Xiaowei; LI Xiaoli

    2006-01-01

    An analytical model on the normal perforation of reinforced concrete slabs is constructed.The effect of reinforcing bars is further hybridized in a general three-stage model consisting of initial cratering,tunnelling and shear plugging.Besides three dimensionless numbers,i.e.,the impact function /,the geometry function of projectile N and the dimensionless thickness of concrete target χ,which are employed to predict the ballistic performance of perforation of concrete slabs,the reinforcement ratio ρs of concrete and the tensile strength fs of reinforcing bars are considered as the other main factors influencing the perforation process.Simpler solutions of ballistic performances of normal perforation of reinforced concrete slabs are formulated.Theoretical predictions agree well with individual published experimental data.

  7. Asymptotic normality and strong consistency of maximum quasi-likelihood estimates in generalized linear models

    Institute of Scientific and Technical Information of China (English)

    YIN; Changming; ZHAO; Lincheng; WEI; Chengdong

    2006-01-01

    In a generalized linear model with q × 1 responses, the bounded and fixed (or adaptive) p × q regressors Zi and the general link function, under the most general assumption on the minimum eigenvalue of ∑ni=1 ZiZ'i, the moment condition on responses as weak as possible and the other mild regular conditions, we prove that the maximum quasi-likelihood estimates for the regression parameter vector are asymptotically normal and strongly consistent.

  8. Two methods for modeling vibrations of planetary gearboxes including faults: Comparison and validation

    Science.gov (United States)

    Parra, J.; Vicuña, Cristián Molina

    2017-08-01

    Planetary gearboxes are important components of many industrial applications. Vibration analysis can increase their lifetime and prevent expensive repair and safety concerns. However, an effective analysis is only possible if the vibration features of planetary gearboxes are properly understood. In this paper, models are used to study the frequency content of planetary gearbox vibrations under non-fault and different fault conditions. Two different models are considered: phenomenological model, which is an analytical-mathematical formulation based on observation, and lumped-parameter model, which is based on the solution of the equations of motion of the system. Results of both models are not directly comparable, because the phenomenological model provides the vibration on a fixed radial direction, such as the measurements of the vibration sensor mounted on the outer part of the ring gear. On the other hand, the lumped-parameter model provides the vibrations on the basis of a rotating reference frame fixed to the carrier. To overcome this situation, a function to decompose the lumped-parameter model solutions to a fixed reference frame is presented. Finally, comparisons of results from both model perspectives and experimental measurements are presented.

  9. Modeling and forecasting foreign exchange daily closing prices with normal inverse Gaussian

    Science.gov (United States)

    Teneng, Dean

    2013-09-01

    We fit the normal inverse Gaussian(NIG) distribution to foreign exchange closing prices using the open software package R and select best models by Käärik and Umbleja (2011) proposed strategy. We observe that daily closing prices (12/04/2008 - 07/08/2012) of CHF/JPY, AUD/JPY, GBP/JPY, NZD/USD, QAR/CHF, QAR/EUR, SAR/CHF, SAR/EUR, TND/CHF and TND/EUR are excellent fits while EGP/EUR and EUR/GBP are good fits with a Kolmogorov-Smirnov test p-value of 0.062 and 0.08 respectively. It was impossible to estimate normal inverse Gaussian parameters (by maximum likelihood; computational problem) for JPY/CHF but CHF/JPY was an excellent fit. Thus, while the stochastic properties of an exchange rate can be completely modeled with a probability distribution in one direction, it may be impossible the other way around. We also demonstrate that foreign exchange closing prices can be forecasted with the normal inverse Gaussian (NIG) Lévy process, both in cases where the daily closing prices can and cannot be modeled by NIG distribution.

  10. Forward modeling and inversion of responses for borehole normal and lateral electrode arrangements

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J.H.

    1986-01-01

    The finite difference method is used to solve the forward problems which simulate the borehole normal and lateral electrode arrangements for the combined boundary (2-D) earth model which has both horizontal and cylindrical boundaries. The ridge regression estimator is then applied to solve the inverse problems which determine the earth parameters such as bed boundaries, extent of invaded zones, and vertical and horizontal resistivity profiles from the borehole normal and lateral resistivity logs. The apparent resistivity values in the presence of borehole mud, invaded zone, and horizontal bed boundaries can be obtained from an earth geometry provided that the model is symmetric around the borehole axis. The quick and accurate forward calculations are achieved by using a gradually expanding grid system and a terminal resistance type boundary condition, and by using a two-dimensional average resistivity scheme in a grid block. The finite difference solutions are verified against analytical solutions for limiting cases, and excellent agreement in obtained. The finite difference forward modeling also can be used for investigation into the effects of the earth parameter variations on the apparent resistivities. Inverse modeling is tested on synthetic and field data. The field data are inverted to a horizontally layered (1-D) model, and the theoretical data are inverted to a 2-D model. The test results indicate that the thickness and the resistivity of each layer can be determined simultaneously. For the practical inversion of field data, the 1-D model inversion results can be used as a first try model of the 2-d inversion. Interactive inverse modeling can be used for an automatic interpretation of the resistivity logs, with models constrained by logging and geologic information.

  11. A two-dimensional simulation model of phosphorus uptake including crop growth and P-response

    NARCIS (Netherlands)

    Mollier, A.; Willigen, de P.; Heinen, M.; Morel, C.; Schneider, A.; Pellerin, S.

    2008-01-01

    Modelling nutrient uptake by crops implies considering and integrating the processes controlling the soil nutrient supply, the uptake by the root system and relationships between the crop growth response and the amount of nutrient absorbed. We developed a model that integrates both dynamics of maize

  12. European column buckling curves and finite element modelling including high strength steels

    DEFF Research Database (Denmark)

    Jönsson, Jeppe; Stan, Tudor-Cristian

    2017-01-01

    Eurocode allows for finite element modelling of plated steel structures, however the information in the code on how to perform the analysis or what assumptions to make is quite sparse. The present paper investigates the deterministic modelling of flexural column buckling using plane shell element...

  13. Dipole model analysis of highest precision HERA data, including very low $Q^2$'s

    CERN Document Server

    Luszczak, Agnieszka

    2016-01-01

    We analyse, within a dipole model, the final, inclusive HERA DIS cross section data in the low $x$ region, using fully correlated errors. We show, that these highest precision data are very well described within the dipole model framework starting from $Q^2$ values of 3.5 GeV$^2$ to the highest values of $Q^2 =$ 250 GeV$^2$.

  14. A Two-Account Life Insurance Model for Scenario-Based Valuation Including Event Risk

    DEFF Research Database (Denmark)

    Jensen, Ninna Reitzel; Schomacker, Kristian Juul

    2015-01-01

    Using a two-account model with event risk, we model life insurance contracts taking into account both guaranteed and non-guaranteed payments in participating life insurance as well as in unit-linked insurance. Here, event risk is used as a generic term for life insurance events, such as death......, disability, etc. In our treatment of participating life insurance, we have special focus on the bonus schemes “consolidation” and “additional benefits”, and one goal is to formalize how these work and interact. Another goal is to describe similarities and differences between participating life insurance...... model by conducting scenario analysis based on Monte Carlo simulation, but the model applies to scenarios in general and to worst-case and best-estimate scenarios in particular. In addition to easy computations, our model offers a common framework for the valuation of life insurance payments across...

  15. A Two-Account Life Insurance Model for Scenario-Based Valuation Including Event Risk

    DEFF Research Database (Denmark)

    Jensen, Ninna Reitzel; Schomacker, Kristian Juul

    2015-01-01

    and unit-linked insurance. By use of a two-account model, we are able to illustrate general concepts without making the model too abstract. To allow for complicated financial markets without dramatically increasing the mathematical complexity, we focus on economic scenarios. We illustrate the use of our......Using a two-account model with event risk, we model life insurance contracts taking into account both guaranteed and non-guaranteed payments in participating life insurance as well as in unit-linked insurance. Here, event risk is used as a generic term for life insurance events, such as death...... product types. This enables comparison of participating life insurance products and unit-linked insurance products, thus building a bridge between the two different ways of formalizing life insurance products. Finally, our model distinguishes itself from the existing literature by taking into account...

  16. Gasification of biomass in a fixed bed downdraft gasifier--a realistic model including tar.

    Science.gov (United States)

    Barman, Niladri Sekhar; Ghosh, Sudip; De, Sudipta

    2012-03-01

    This study presents a model for fixed bed downdraft biomass gasifiers considering tar also as one of the gasification products. A representative tar composition along with its mole fractions, as available in the literature was used as an input parameter within the model. The study used an equilibrium approach for the applicable gasification reactions and also considered possible deviations from equilibrium to further upgrade the equilibrium model to validate a range of reported experimental results. Heat balance was applied to predict the gasification temperature and the predicted values were compared with reported results in literature. A comparative study was made with some reference models available in the literature and also with experimental results reported in the literature. Finally a predicted variation of performance of the gasifier by this validated model for different air-fuel ratio and moisture content was also discussed.

  17. Including Tropical Croplands in a Terrestrial Biosphere Model: Application to West Africa

    Science.gov (United States)

    Berg, A.; Sultan, B.; de Noblet, N.

    2008-12-01

    Studying the large-scale relationships between climate and agriculture raises two different issues: the impact of climate on crops, and the potential feedbacks to climate from croplands. A relevant framework to consistently address this twofold issue is to extend existing Dynamic Global Vegetation Models, which can be coupled to climate models, in order to explicitly account for croplands. Here we present the first results of such a strategy applied to tropical croplands over West Africa. We introduce directly into the terrestrial biosphere model ORCHIDEE (IPSL) adequate processes and parametrizations taken from the crop model SARRAH (CIRAD), which is calibrated for millet over this region. The resulting model, ORCH-mil, realistically simulates the growth and yield of millet when tested on an experimental station in Senegal. The model is then applied over West Africa using a 36-year climate reanalysis dataset. First the model is tested in terms of yield simulation, against national millet yields from the FAO database. The ability of the model to reproduce the spatial and temporal variability of millet yields is assessed. Then, the effects on land surface fluxes of explicitly accounting for croplands are examined, by comparison between ORCH-mil and ORCHIDEE. These first simulations show consistent results, but underline the need for some further development and validation of the model if it is to simulate yields accurately. In terms of land surface fluxes, significant differences between ORCH-mil and ORCHIDEE appear, mainly via changes in evaporation and albedo. The potential impact on the west African monsoon system of such differences needs to be investigated by coupling ORCH-mil to a climate model: first results from such an experiment will be presented.

  18. Spatial modelling of marine organisms in Forsmark and Oskarshamn. Including calculation of physical predictor variables

    Energy Technology Data Exchange (ETDEWEB)

    Carlen, Ida; Nikolopoulos, Anna; Isaeus, Martin (AquaBiota Water Research, Stockholm (SE))

    2007-06-15

    GIS grids (maps) of marine parameters were created using point data from previous site investigations in the Forsmark and Oskarshamn areas. The proportion of global radiation reaching the sea bottom in Forsmark and Oskarshamn was calculated in ArcView, using Secchi depth measurements and the digital elevation models for the respective area. The number of days per year when the incoming light exceeds 5 MJ/m2 at the bottom was then calculated using the result of the previous calculations together with measured global radiation. Existing modelled grid-point data on bottom and pelagic temperature for Forsmark were interpolated to create surface covering grids. Bottom and pelagic temperature grids for Oskarshamn were calculated using point measurements to achieve yearly averages for a few points and then using regressions with existing grids to create new maps. Phytoplankton primary production in Forsmark was calculated using point measurements of chlorophyll and irradiance, and a regression with a modelled grid of Secchi depth. Distribution of biomass of macrophyte communities in Forsmark and Oskarshamn was calculated using spatial modelling in GRASP, based on field data from previous surveys. Physical parameters such as those described above were used as predictor variables. Distribution of biomass of different functional groups of fish in Forsmark was calculated using spatial modelling based on previous surveys and with predictor variables such as physical parameters and results from macrophyte modelling. All results are presented as maps in the report. The quality of the modelled predictions varies as a consequence of the quality and amount of the input data, the ecology and knowledge of the predicted phenomena, and by the modelling technique used. A substantial part of the variation is not described by the models, which should be expected for biological modelling. Therefore, the resulting grids should be used with caution and with this uncertainty kept in mind. All

  19. Inferences in Linear Mixed Models with Skew-normal Random Eff ects

    Institute of Scientific and Technical Information of China (English)

    Ren Dao YE; Tong Hui WANG

    2015-01-01

    For the linear mixed model with skew-normal random eff ects, this paper gives the density function, moment generating function and independence conditions. The noncentral skew chi-square distribution is defined and its density function is shown. The necessary and suffi cient conditions under which a quadratic form is distributed as noncentral skew chi-square distribution are obtained. Also, a version of Cochran’s theorem is given, which modifies the result of Wang et al. (2009) and is used to set up exact tests for fixed eff ects and variance components of the proposed model. For illustration, our main results are applied to a real data problem.

  20. Risk estimation based on mixed normal distribution model for diabetes-related hospitalization claims

    Institute of Scientific and Technical Information of China (English)

    WANG Xin-wang; WANG Juan; FANG Ji-qian

    2006-01-01

    @@ Medical insurance service, the important part of national healthcare supporting system with a history dating back more than 100 years ago,remains a global challenge because of its high rates of compensation and difficulty in risk control. When developing the diabetes related, hospitalization insurance, we found that the risk loss of the diabetic inpatients does not follow a symmetrical unimodal distribution: in fact, it is hard to describe its risk loses distribution with a single probability distribution model. Therefore, we put forward a risk measurement method based on a mixed normal distributions model for medical insurance of inpatients with diabetes.

  1. Asymptotic normality of the QMLE in the level-effect ARCH model

    DEFF Research Database (Denmark)

    Dahl, Christian Møller; Iglesias, Emma M.

    In this paper consistency and asymptotic normality of the quasi maximum like-lihood estimator in the level-effect ARCH model of Chan, Karolyi, Longstaff and Sanders (1992) is established. We consider explicitly the case where the parameters of the conditional heteroskedastic process...... are in the stationary region and discuss carefully how the results can be extended to the region where the conditional heteroskedastic process is nonstationary. The results illustrate that Jensen and Rahbek's (2004a,2004b) approach can be extended further than to traditional ARCH and GARCH models....

  2. Modeled hydraulic redistribution by Helianthus annuus L. matches observed data only after model modification to include nighttime transpiration

    Science.gov (United States)

    Neumann, R. B.; Cardon, Z. G.; Rockwell, F. E.; Teshera-Levye, J.; Zwieniecki, M.; Holbrook, N. M.

    2013-12-01

    The movement of water from moist to dry soil layers through the root systems of plants, referred to as hydraulic redistribution (HR), occurs throughout the world and is thought to influence carbon and water budgets and ecosystem functioning. The realized hydrologic, biogeochemical, and ecological consequences of HR depend on the amount of redistributed water, while the ability to assess these impacts requires models that correctly capture HR magnitude and timing. Using several soil types and two eco-types of Helianthus annuus L. in split-pot experiments, we examined how well the widely used HR modeling formulation developed by Ryel et al. (2002) could match experimental determination of HR across a range of water potential driving gradients. H. annuus carries out extensive nighttime transpiration, and though over the last decade it has become more widely recognized that nighttime transpiration occurs in multiple species and many ecosystems, the original Ryel et al. (2002) formulation does not include the effect of nighttime transpiration on HR. We developed and added a representation of nighttime transpiration into the formulation, and only then was the model able to capture the dynamics and magnitude of HR we observed as soils dried and nighttime stomatal behavior changed, both influencing HR.

  3. Constraints on gen4eralized Chaplygin gas model including gamma-ray bursts

    Institute of Scientific and Technical Information of China (English)

    Fa-Yin Wang; Zi-Gao Dai; Shi Qi

    2009-01-01

    Generalized Chaplygin gas (whose equation of state is PGCG = -A/PGCGα) was proposed as a candidate for unification of dark energy and dark matter. We inves-tigate constraints on this model with the latest observed data. We test the model with type-Ia supernovae (SNe Ia), cosmic microwave background (CMB) anisotropy, X-ray gas mass fractions in clusters, and gamma-ray bursts (GRBs). We calibrate the GRB lu-minosity relations without assuming any cosmological models using SNe Ia. We show that GRBs can extend the Hubble diagram to higher redshifts (z> 6). The GRB Hubble diagram is well behaved and delineates the shape of the Hubble diagram well. We mea-sure As≡A/PGCG,0α+1=0.68-0.08+0.04 (where PGCG,0 is the energy density today) and α=-0.22-0.13+0.15at the 1σconfidence level using all the datasets. Our results rule out the standard Chaplygin gas model (α = 1) at the 3a confidence level. The ACDM is allowed at the 2or confidence level. We find that acceleration could have started at a redshift of z ~ 0.70. The concordance of the generalized Chaplygin gas model with the age estimate of an old high redshift quasar is found. In addition, we show that GRBs can break the degeneracy between the generalized Chaplygin gas model and the XCDM model.

  4. Simulated village locations in Thailand: A multi-scale model including a neural network approach.

    Science.gov (United States)

    Tang, Wenwu; Malanson, George P; Entwisle, Barbara

    2009-04-01

    The simulation of rural land use systems, in general, and rural settlement dynamics in particular has developed with synergies of theory and methods for decades. Three current issues are: linking spatial patterns and processes, representing hierarchical relations across scales, and considering nonlinearity to address complex non-stationary settlement dynamics. We present a hierarchical simulation model to investigate complex rural settlement dynamics in Nang Rong, Thailand. This simulation uses sub-models to allocate new villages at three spatial scales. Regional and sub-regional models, which involve a nonlinear space-time autoregressive model implemented in a neural network approach, determine the number of new villages to be established. A dynamic village niche model, establishing pattern-process link, was designed to enable the allocation of villages into specific locations. Spatiotemporal variability in model performance indicates the pattern of village location changes as a settlement frontier advances from rice-growing lowlands to higher elevations. Experiments results demonstrate this simulation model can enhance our understanding of settlement development in Nang Rong and thus gain insight into complex land use systems in this area.

  5. A Two-Account Life Insurance Model for Scenario-Based Valuation Including Event Risk

    Directory of Open Access Journals (Sweden)

    Ninna Reitzel Jensen

    2015-06-01

    Full Text Available Using a two-account model with event risk, we model life insurance contracts taking into account both guaranteed and non-guaranteed payments in participating life insurance as well as in unit-linked insurance. Here, event risk is used as a generic term for life insurance events, such as death, disability, etc. In our treatment of participating life insurance, we have special focus on the bonus schemes “consolidation” and “additional benefits”, and one goal is to formalize how these work and interact. Another goal is to describe similarities and differences between participating life insurance and unit-linked insurance. By use of a two-account model, we are able to illustrate general concepts without making the model too abstract. To allow for complicated financial markets without dramatically increasing the mathematical complexity, we focus on economic scenarios. We illustrate the use of our model by conducting scenario analysis based on Monte Carlo simulation, but the model applies to scenarios in general and to worst-case and best-estimate scenarios in particular. In addition to easy computations, our model offers a common framework for the valuation of life insurance payments across product types. This enables comparison of participating life insurance products and unit-linked insurance products, thus building a bridge between the two different ways of formalizing life insurance products. Finally, our model distinguishes itself from the existing literature by taking into account the Markov model for the state of the policyholder and, hereby, facilitating event risk.

  6. Potential transformation of trace species including aircraft exhaust in a cloud environment. The `Chedrom model`

    Energy Technology Data Exchange (ETDEWEB)

    Ozolin, Y.E.; Karol, I.L. [Main Geophysical Observatory, St. Petersburg (Russian Federation); Ramaroson, R. [Office National d`Etudes et de Recherches Aerospatiales (ONERA), 92 - Chatillon (France)

    1997-12-31

    Box model for coupled gaseous and aqueous phases is used for sensitivity study of potential transformation of trace gases in a cloud environment. The rate of this transformation decreases with decreasing of pH in droplets, with decreasing of photodissociation rates inside the cloud and with increasing of the droplet size. Model calculations show the potential formation of H{sub 2}O{sub 2} in aqueous phase and transformation of gaseous HNO{sub 3} into NO{sub x} in a cloud. This model is applied for exploration of aircraft exhausts evolution in plume inside a cloud. (author) 10 refs.

  7. A Two-Dimensional Modeling Procedure to Estimate the Loss Equivalent Resistance Including the Saturation Effect

    Directory of Open Access Journals (Sweden)

    Rosa Ana Salas

    2013-11-01

    Full Text Available We propose a modeling procedure specifically designed for a ferrite inductor excited by a waveform in time domain. We estimate the loss resistance in the core (parameter of the electrical model of the inductor by means of a Finite Element Method in 2D which leads to significant computational advantages over the 3D model. The methodology is validated for an RM (rectangular modulus ferrite core working in the linear and the saturation regions. Excellent agreement is found between the experimental data and the computational results.

  8. Recent Advances in Study on Thermodynamic Models for Real Systems Including Electrolytes

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    A comprehensive review of recent advances in study on thermodynamic models for real electrolyte solutions is presented. The differences between primitive and non-primitive electrolyte models are demonstrated. Some new thermodynamic models for electrolyte solutions based on the mean spherical approximation and perturbation theory are introduced. An extended scaled-particle theory and modified CleggPitz er equation are presented for physical and chemical absorption processes with mixed solvents, respectively. A pseudo one-component two-Yukawa equation of state is used for the aqueous two-phase extraction process in charged colloidal systems.

  9. Extension of Lithium Ion Cell Model to Include Transient and Low-Temperature Behaviour

    Science.gov (United States)

    Dudley, G.

    2014-08-01

    Current-interruption resistance measurements have been analysed in detail allowing the ESTEC lithium ion cell electrical/thermal model to be extended to allow modelling of cell voltage in response to imposed current changes at low temperatures and short time scales where activation polarisation becomes important. Whilst an unnecessary complication in most cases, this extension is needed under certain circumstances such as the simulation of Mars rover batteries forced to operate at low temperature and possible effects of battery voltage transients on battery-bus power subsystems. Comparison with test data show that the model is capable of giving a good fit in these circumstances.

  10. An accurate simulation model for single-photon avalanche diodes including important statistical effects

    Science.gov (United States)

    Qiuyang, He; Yue, Xu; Feifei, Zhao

    2013-10-01

    An accurate and complete circuit simulation model for single-photon avalanche diodes (SPADs) is presented. The derived model is not only able to simulate the static DC and dynamic AC behaviors of an SPAD operating in Geiger-mode, but also can emulate the second breakdown and the forward bias behaviors. In particular, it considers important statistical effects, such as dark-counting and after-pulsing phenomena. The developed model is implemented using the Verilog-A description language and can be directly performed in commercial simulators such as Cadence Spectre. The Spectre simulation results give a very good agreement with the experimental results reported in the open literature. This model shows a high simulation accuracy and very fast simulation rate.

  11. Extending the Scope of the Acculturation/Pidginization Model to Include Cognition.

    Science.gov (United States)

    Schumann, John H.

    1990-01-01

    Examines five cognitive models for second-language acquisition (SLA) and assesses how each might account for the Pidginized interlanguage found in the early stages of second-language acquisition. (23 references) (JL)

  12. A model for including Arduino microcontroller programming in the introductory physics lab

    CERN Document Server

    Haugen, Andrew J

    2014-01-01

    The paper describes a curricular framework for introducing microcontroller programming in the University Physics lab. The approach makes use of Modeling Instruction, an effective approach for teaching science at the secondary level in which student learn the standard material by developing and deploying models of the physical world. In our approach, students engage with a context-rich problem that can be solved with one or more sensors and a microcontroller. The solution path we describe then consists of developing a mathematical model for how the sensors' data can be mapped to a meaningful measurement, and further, developing an algorithmic model that will be implemented in the microcontroller. Once the system is developed and implemented, students are given an array of similar problems in which they can deploy their data collection system. Results from the implementation of this idea, in two University Physics sections, using Arduino microcontrollers, are also described.

  13. Global warming in a coupled climate model including oceanic eddy-induced advection

    Science.gov (United States)

    Hirst, Anthony C.; Gordon, Hal B.; O'Farrell, Siobhan P.

    The Gent and McWilliams (GM) parameterization for large-scale water transport caused by mesoscale oceanic eddies is introduced into the oceanic component of a global coupled ocean-atmosphere model. Parallel simulations with and without the GM scheme are performed to examine the effect of this parameterization on model behavior under constant atmospheric CO2 and on the model response to increasing CO2. The control (constant CO2) runs show substantial differences in the oceanic stratification and extent of convection, similar to differences found previously using uncoupled ocean models. The transient (increasing CO2) runs show moderate differences in the rate of oceanic heat sequestration (less in the GM case), as expected based on passive tracer uptake studies. However, the surface warming is weaker in the GM case, especially over the Southern Ocean, which is contrary to some recent supposition. Reasons for the reduced warming in the GM case are discussed.

  14. Empirical Validation of a Thermal Model of a Complex Roof Including Phase Change Materials

    CERN Document Server

    Guichard, Stéphane; Bigot, Dimitri; Malet-Damour, Bruno; Libelle, Teddy; Boyer, Harry

    2015-01-01

    This paper deals with the empirical validation of a building thermal model using a phase change material (PCM) in a complex roof. A mathematical model dedicated to phase change materials based on the heat apparent capacity method was implemented in a multi-zone building simulation code, the aim being to increase understanding of the thermal behavior of the whole building with PCM technologies. To empirically validate the model, the methodology is based both on numerical and experimental studies. A parametric sensitivity analysis was performed and a set of parameters of the thermal model have been identified for optimization. The use of a generic optimization program called GenOpt coupled to the building simulation code enabled to determine the set of adequate parameters. We first present the empirical validation methodology and main results of previous work. We then give an overview of GenOpt and its coupling with the building simulation code. Finally, once the optimization results are obtained, comparisons o...

  15. Pharmacokinetic-pharmacodynamic modeling of diclofenac in normal and Freund's complete adjuvant-induced arthritic rats

    Institute of Scientific and Technical Information of China (English)

    Jing ZHANG; Pei LI; Hai-fang GUO; Li LIU; Xiao-dong LIU

    2012-01-01

    Aim:To characterize pharmacokinetic-pharmacodynamic modeling of diclofenac in Freund's complete adjuvant (FCA)-induced arthritic rats using prostaglandin E2 (PGE2) as a biomarker.Methods:The pharmacokinetics of diclofenac was investigated using 20-day-old arthritic rats.PGE2 level in the rats was measured using an enzyme immunoassay.A pharmacokinetic-pharmacodynamic (PK-PD) model was developed to illustrate the relationship between the plasma concentration of diclofenac and the inhibition of PGE2 production.The inhibition of diclofenac on lipopolysaccharide (LPS)-induced PGE2 production in blood cells was investigated in vitro.Results:Similar pharmacokinetic behavior of diclofenac was found both in normal and FCA-induced arthritic rats.Diclofenac significantly decreased the plasma levels of PGE2 in both normal and arthritic rats.The inhibitory effect on PGE2 levels in the plasma was in proportion to the plasma concentration of diclofenac.No delay in the onset of inhibition was observed,suggesting that the effect compartment was located in the central compartment.An inhibitory effect sigmoid/max model was selected to characterize the relationship between the plasma concentration of diclofenac and the inhibition of PGE2 production in vivo.The /max model was also used to illustrate the inhibition of diclofenac on LPS-induced PGE2 production in blood cells in vitro.Conclusion:Arthritis induced by FCA does not alter the pharmacokinetic behaviors of diclofenac in rats,but the pharmacodynamics of diclofenac is slightly affected.A PK-PD model characterizing an inhibitory effect sigmoid /max can be used to fit the relationship between the plasma PGE2 and diclofenac levels in both normal rats and FCA-induced arthritic rats.

  16. A Coupled MHD and Thermal Model Including Electrostatic Sheath for Magnetoplasmadynamic Thruster Simulation

    Science.gov (United States)

    Kawasaki, Akira; Kubota, Kenichi; Funaki, Ikkoh; Okuno, Yoshihiro

    2016-09-01

    Steady-state and self-field magnetoplasmadynamic (MPD) thruster, which utilizes high-intensity direct-current (DC) discharge, is one of the prospective candidates of future high-power electric propulsion devices. In order to accurately assess the thrust performance and the electrode temperature, input electric power and wall heat flux must correctly be evaluated where electrostatic sheaths formed in close proximity of the electrodes affect these quantities. Conventional model simulates only plasma flows occurring in MPD thrusters with the absence of electrostatic sheath consideration. Therefore, this study extends the conventional model to a coupled magnetohydrodynamic (MHD) and thermal model by incorporating the phenomena relevant to the electrostatic sheaths. The sheaths are implemented as boundary condition of the MHD model on the walls. This model simulated the operation of the 100-kW-class thruster at discharge current ranging from 6 to 10 kA with argon propellant. The extended model reproduced the discharge voltages and wall heat load which are consistent with past experimental results. In addition, the simulation results indicated that cathode sheath voltages account for approximately 5-7 V subject to approximately 20 V of discharge voltages applied between the electrodes. This work was supported by JSPS KAKENHI Grant Numbers 26289328 and 15J10821.

  17. Including sugar cane in the agro-ecosystem model ORCHIDEE-STICS: calibration and validation

    Science.gov (United States)

    Valade, A.; Vuichard, N.; Ciais, P.; Viovy, N.

    2011-12-01

    Sugarcane is currently the most efficient bioenergy crop with regards to the energy produced per hectare. With approximately half the global bioethanol production in 2005, and a devoted land area expected to expand globally in the years to come, sugar cane is at the heart of the biofuel debate. Dynamic global vegetation models coupled with agronomical models are powerful and novel tools to tackle many of the environmental issues related to biofuels if they are carefully calibrated and validated against field observations. Here we adapt the agro-terrestrial model ORCHIDEE-STICS for sugar cane simulations. Observation data of LAI are used to evaluate the sensitivity of the model to parameters of nitrogen absorption and phenology, which are calibrated in a systematic way for six sites in Australia and La Reunion. We find that the optimal set of parameters is highly dependent on the sites' characteristics and that the model can reproduce satisfactorily the evolution of LAI. This careful calibration of ORCHIDEE-STICS for sugar cane biomass production for different locations and technical itineraries provides a strong basis for further analysis of the impacts of bioenergy-related land use change on carbon cycle budgets. As a next step, a sensitivity analysis is carried out to estimate the uncertainty of the model in biomass and carbon flux simulation due to its parameterization.

  18. Large Eddy simulation of turbulence: A subgrid scale model including shear, vorticity, rotation, and buoyancy

    Science.gov (United States)

    Canuto, V. M.

    1994-01-01

    The Reynolds numbers that characterize geophysical and astrophysical turbulence (Re approximately equals 10(exp 8) for the planetary boundary layer and Re approximately equals 10(exp 14) for the Sun's interior) are too large to allow a direct numerical simulation (DNS) of the fundamental Navier-Stokes and temperature equations. In fact, the spatial number of grid points N approximately Re(exp 9/4) exceeds the computational capability of today's supercomputers. Alternative treatments are the ensemble-time average approach, and/or the volume average approach. Since the first method (Reynolds stress approach) is largely analytical, the resulting turbulence equations entail manageable computational requirements and can thus be linked to a stellar evolutionary code or, in the geophysical case, to general circulation models. In the volume average approach, one carries out a large eddy simulation (LES) which resolves numerically the largest scales, while the unresolved scales must be treated theoretically with a subgrid scale model (SGS). Contrary to the ensemble average approach, the LES+SGS approach has considerable computational requirements. Even if this prevents (for the time being) a LES+SGS model to be linked to stellar or geophysical codes, it is still of the greatest relevance as an 'experimental tool' to be used, inter alia, to improve the parameterizations needed in the ensemble average approach. Such a methodology has been successfully adopted in studies of the convective planetary boundary layer. Experienc e with the LES+SGS approach from different fields has shown that its reliability depends on the healthiness of the SGS model for numerical stability as well as for physical completeness. At present, the most widely used SGS model, the Smagorinsky model, accounts for the effect of the shear induced by the large resolved scales on the unresolved scales but does not account for the effects of buoyancy, anisotropy, rotation, and stable stratification. The

  19. A model for the evolution of large density perturbations - Normalization and predictions. [In universe

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Gonzalez, E.; Sanz, J.L. (Cantabria Universidad, Santander (Spain))

    1991-01-01

    The nonlinear evolution of matter density fluctuations in the universe is studied. The Zeldovich solution is applied to the quasi-linear regime, and a model to stop the fluctuations from growing in the very nonlinear regime is considered. The model is based in the virialization of collapsing pancakes. The density contrast of a typical pancake at the time it starts to relax is given for universes with different values of Omega. With this model, it is possible to calculate the probability density of the final density fluctuations. Results on the normalization of the power spectrum of the initial density fluctuations are given as a function of Omega. Predictions of the model on the filling factor of superclusters and voids are compared with observations. 37 refs.

  20. Accurate and efficient modeling of global seismic wave propagation for an attenuative Earth model including the center

    Science.gov (United States)

    Toyokuni, Genti; Takenaka, Hiroshi

    2012-06-01

    We propose a method for modeling global seismic wave propagation through an attenuative Earth model including the center. This method enables accurate and efficient computations since it is based on the 2.5-D approach, which solves wave equations only on a 2-D cross section of the whole Earth and can correctly model 3-D geometrical spreading. We extend a numerical scheme for the elastic waves in spherical coordinates using the finite-difference method (FDM), to solve the viscoelastodynamic equation. For computation of realistic seismic wave propagation, incorporation of anelastic attenuation is crucial. Since the nature of Earth material is both elastic solid and viscous fluid, we should solve stress-strain relations of viscoelastic material, including attenuative structures. These relations represent the stress as a convolution integral in time, which has had difficulty treating viscoelasticity in time-domain computation such as the FDM. However, we now have a method using so-called memory variables, invented in the 1980s, followed by improvements in Cartesian coordinates. Arbitrary values of the quality factor (Q) can be incorporated into the wave equation via an array of Zener bodies. We also introduce the multi-domain, an FD grid of several layers with different grid spacings, into our FDM scheme. This allows wider lateral grid spacings with depth, so as not to perturb the FD stability criterion around the Earth center. In addition, we propose a technique to avoid the singularity problem of the wave equation in spherical coordinates at the Earth center. We develop a scheme to calculate wavefield variables on this point, based on linear interpolation for the velocity-stress, staggered-grid FDM. This scheme is validated through a comparison of synthetic seismograms with those obtained by the Direct Solution Method for a spherically symmetric Earth model, showing excellent accuracy for our FDM scheme. As a numerical example, we apply the method to simulate seismic

  1. A two-phase solid/fluid model for dense granular flows including dilatancy effects

    Science.gov (United States)

    Mangeney, Anne; Bouchut, Francois; Fernandez-Nieto, Enrique; Koné, El-Hadj; Narbona-Reina, Gladys

    2016-04-01

    Describing grain/fluid interaction in debris flows models is still an open and challenging issue with key impact on hazard assessment [{Iverson et al.}, 2010]. We present here a two-phase two-thin-layer model for fluidized debris flows that takes into account dilatancy effects. It describes the velocity of both the solid and the fluid phases, the compression/dilatation of the granular media and its interaction with the pore fluid pressure [{Bouchut et al.}, 2016]. The model is derived from a 3D two-phase model proposed by {Jackson} [2000] based on the 4 equations of mass and momentum conservation within the two phases. This system has 5 unknowns: the solid and fluid velocities, the solid and fluid pressures and the solid volume fraction. As a result, an additional equation inside the mixture is necessary to close the system. Surprisingly, this issue is inadequately accounted for in the models that have been developed on the basis of Jackson's work [{Bouchut et al.}, 2015]. In particular, {Pitman and Le} [2005] replaced this closure simply by imposing an extra boundary condition at the surface of the flow. When making a shallow expansion, this condition can be considered as a closure condition. However, the corresponding model cannot account for a dissipative energy balance. We propose here an approach to correctly deal with the thermodynamics of Jackson's model by closing the mixture equations by a weak compressibility relation following {Roux and Radjai} [1998]. This relation implies that the occurrence of dilation or contraction of the granular material in the model depends on whether the solid volume fraction is respectively higher or lower than a critical value. When dilation occurs, the fluid is sucked into the granular material, the pore pressure decreases and the friction force on the granular phase increases. On the contrary, in the case of contraction, the fluid is expelled from the mixture, the pore pressure increases and the friction force diminishes. To

  2. Including the effects of debris cover in a distributed glacier energy balance model (Invited)

    Science.gov (United States)

    Pellicciotti, F.; Reid, T.; Carenzo, M.; Brock, B. W.

    2010-12-01

    Distributed models of glacier energy balance, which make use of digital elevation models and extensive spatial data on local meteorology, have become very useful tools for predicting glacial ablation and runoff in recent years. They generally function by running a one-dimensional energy balance model at every point on a grid on the glacier surface - for each point in the grid the ablation is calculated based on the balance of heat fluxes at the ice-air boundary. However, one key component has been missing from distributed models to date, namely the effects of debris cover. Many glacier ablation zones are mantled in near-continuous blankets of rock debris, and debris-covered glaciers are important drivers of the water cycle in the European Alps, Andes and Himalayas. Moreover, debris covers have been seen to expand in recent years, so it is essential to assess exactly how the presence of debris may affect a glacier’s surface energy balance and potential responses to climate changes. The effects of a debris cover are complicated by the varying surface roughness, albedo and thermal properties of the debris in question, but generally a debris cover reduces glacier melt rate by insulating the glacier surface from direct solar radiation. Even on glaciers where the debris cover is not continuous, isolated patches of debris caused by rockfalls can affect the glacier evolution by introducing differential ablation across the glacier surface, thus creating ice-cored moraines that may persist after ‘clean’ parts of the glacier have wasted away. This paper presents the results of incorporating a one-dimensional ‘debris energy balance model’ called DEB-Model (Reid and Brock 2010) into a distributed melt model for Haut Glacier d’Arolla, Switzerland. DEB-Model numerically estimates debris surface temperature by considering the balance of heat fluxes at the air-debris interface, then calculates heat conduction through the debris in order to estimate melt rates at the

  3. Pancreatic Response to Gold Nanoparticles Includes Decrease of Oxidative Stress and Inflammation In Autistic Diabetic Model

    Directory of Open Access Journals (Sweden)

    Manar E. Selim

    2015-01-01

    Full Text Available Background: Gold nanoparticles (AuNPs have a wide range of applications in various fields. This study provides an understanding of the modulatory effects of AuNPs on an antioxidant system in male Wistar diabetic rats with autism spectrum disorder (ASD. Normal littermates fed by control mothers were injected with citrate buffer alone and served as normal, untreated controls controlin this study. Diabetes mellitus (DM was induced by administering a single intraperitoneal injection of streptozotocin (STZ (100 mg/kg to the pups of (ND diabetic group, which had been fasted overnight. Autistic pups from mothers that had received a single intraperitoneal injection of 600 mg/kg sodium valproate on day 12.5 after conception were randomly divided into 2 groups (n 2 7/group as follow; administering single intraperitoneal injection of streptozotocin (STZ ( (100 mg/kg to the overnight fasted autistic pups of (AD autistic diabetic group. The treatment was started on the 5th day after STZ injection with the same dose as in group II and it was considered as 1st day of treatment with gold nanoparticles for 7 days to each rat of (group IV treated autistic diabetic group(TAD at a dosage of 2.5 mg/kg. b. wt. Results: At this dose of administration AuNPs, the activities of hepatic superoxide dismutase (SOD, glutathione peroxidase (GPx, and catalase were greater in group TAD compared with the control group (P 0.05 in the liver of autistic diabetic AuNPs -supplemented rats, whereas reduced glutathione was markedly higher than in control rats, especially after administration of AuNPs. Moreover, the kidney functions in addition to the fat profile scoring supported the protective potential of that dose of AuNPs. The beta cells revealed euchromatic nuclei with no evidence of separation of nuclear membrane. Conclusions: Our results showed that AuNPs improved many of the oxidative stress parameters (SOD, GPx and, CAT, plasma antioxidant capacity (ORAC and lipid profile

  4. An induction machine model including interbar currents for studying performances during transients and steady state

    Energy Technology Data Exchange (ETDEWEB)

    Razik, H. [Universite Henri Poincare, GREEN, CNRS-UMR 7037, BP 239, F-54506 Vandoeuvre-les-Nancy Cedex (France); Henao, H. [University of Picardie, CREA, 33 rue Saint Leu, F-80039 Amiens Cedex 1 (France); Carlson, R. [GRUCAD/CTC/UFSC, Campus Universitario, C.P. 436, Florianopolis - SC, 88040-900 (Brazil)

    2009-01-15

    This paper presents a mathematical model of a three-phase induction motor taking into consideration the interbar contacts. Several models have been available in the references. However, they consider the rotor of the induction motor as being constituted either a three-phase or a squirrel cage even if it operates under stator and/or rotor faults condition. Nonetheless, the contact between a bar and the iron core for the machine has to be considered, especially when a rotor fault occurs. It is obvious that rotor currents are under the influence of rotor constitution materials. So, the paper aim's concerns a transient model of the induction motors which can consider the rotor broken bars defect. Despite its increasing complexity, it could be able to provide with useful indications for diagnostic purposes. This model is advocated for the simulation of motors behavior under rotor defect which takes into account the interbar currents. The proposed technique is based on the mesh model analysis of the squirrel cage. As low power induction motors are prevalent in industrial plants, we pay a special attention on them. Notwithstanding, additional currents are due to the contact between the non-insulated bar constituting the squirrel cage to the rotor iron core. The monitoring of induction motors is predominantly made through the stator current analysis of the motor when it operates at nominal condition. Moreover, this one is observed in steady state operating system, knowing that the motor is generally fed by a sinusoidal supply. Consequently, simulation results showed in this paper prove the effectiveness of the proposed approach, and the impact of interbar resistance both on the model and the line current spectrum for the diagnostic. An experimental test proves the effectiveness of this model. (author)

  5. Including crystal structure attributes in machine learning models of formation energies via Voronoi tessellations

    Science.gov (United States)

    Ward, Logan; Liu, Ruoqian; Krishna, Amar; Hegde, Vinay I.; Agrawal, Ankit; Choudhary, Alok; Wolverton, Chris

    2017-07-01

    While high-throughput density functional theory (DFT) has become a prevalent tool for materials discovery, it is limited by the relatively large computational cost. In this paper, we explore using DFT data from high-throughput calculations to create faster, surrogate models with machine learning (ML) that can be used to guide new searches. Our method works by using decision tree models to map DFT-calculated formation enthalpies to a set of attributes consisting of two distinct types: (i) composition-dependent attributes of elemental properties (as have been used in previous ML models of DFT formation energies), combined with (ii) attributes derived from the Voronoi tessellation of the compound's crystal structure. The ML models created using this method have half the cross-validation error and similar training and evaluation speeds to models created with the Coulomb matrix and partial radial distribution function methods. For a dataset of 435 000 formation energies taken from the Open Quantum Materials Database (OQMD), our model achieves a mean absolute error of 80 meV/atom in cross validation, which is lower than the approximate error between DFT-computed and experimentally measured formation enthalpies and below 15% of the mean absolute deviation of the training set. We also demonstrate that our method can accurately estimate the formation energy of materials outside of the training set and be used to identify materials with especially large formation enthalpies. We propose that our models can be used to accelerate the discovery of new materials by identifying the most promising materials to study with DFT at little additional computational cost.

  6. Bivariate categorical data analysis using normal linear conditional multinomial probability model.

    Science.gov (United States)

    Sun, Bingrui; Sutradhar, Brajendra

    2015-02-10

    Bivariate multinomial data such as the left and right eyes retinopathy status data are analyzed either by using a joint bivariate probability model or by exploiting certain odds ratio-based association models. However, the joint bivariate probability model yields marginal probabilities, which are complicated functions of marginal and association parameters for both variables, and the odds ratio-based association model treats the odds ratios involved in the joint probabilities as 'working' parameters, which are consequently estimated through certain arbitrary 'working' regression models. Also, this later odds ratio-based model does not provide any easy interpretations of the correlations between two categorical variables. On the basis of pre-specified marginal probabilities, in this paper, we develop a bivariate normal type linear conditional multinomial probability model to understand the correlations between two categorical variables. The parameters involved in the model are consistently estimated using the optimal likelihood and generalized quasi-likelihood approaches. The proposed model and the inferences are illustrated through an intensive simulation study as well as an analysis of the well-known Wisconsin Diabetic Retinopathy status data.

  7. High resolution multi model Climate change scenario over India including first uncertainty assessment

    Science.gov (United States)

    Kumar, P.; Wiltshire, A.; Asharaf, S.; Ahrens, B.; Lucas-Picher, P.; Christensen, J. H.; Gobiet, A.; Saeed, F.; Hagemann, S.; Jacob, D.

    2011-12-01

    This study presents the possible regional climate change over SA with a focus over India as simulated by three very-high-resolution regional climate models. The models are driven by the same lateral boundary conditions from two global models (ECHAM5-MPIOM and HadCM3) under the IPCC AR4 SRES A1B scenario at horizontal resolution of ~25km, except one model which is simulated for only one GCM. The results are presented for two time slices 2021-2050 and 2070-2099. The analysis concentrates along precipitation and temperature over land and focuses mainly on the monsoon season. The circulation parameter is also discussed. In general all models show a clear signal of gradual wide-spread warming throughout the 21st century. The ensemble-mean warming evident at the end of 2050 is 1-2K, whereas it is 3-5K at the end of century. The projected pattern of the precipitation change shows spatial variability. The increase in precipitation is noticed over peninsular and coastal areas and no change or decrease over areas away from the ocean. The influence of the driving GCM on projected precipitation change simulated with each RCM is as strong as the variability among the RCMs driven with one GCM. Some results of the first uncertainties assessment are also presented.

  8. HIV model parameter estimates from interruption trial data including drug efficacy and reservoir dynamics.

    Directory of Open Access Journals (Sweden)

    Rutao Luo

    Full Text Available Mathematical models based on ordinary differential equations (ODE have had significant impact on understanding HIV disease dynamics and optimizing patient treatment. A model that characterizes the essential disease dynamics can be used for prediction only if the model parameters are identifiable from clinical data. Most previous parameter identification studies for HIV have used sparsely sampled data from the decay phase following the introduction of therapy. In this paper, model parameters are identified from frequently sampled viral-load data taken from ten patients enrolled in the previously published AutoVac HAART interruption study, providing between 69 and 114 viral load measurements from 3-5 phases of viral decay and rebound for each patient. This dataset is considerably larger than those used in previously published parameter estimation studies. Furthermore, the measurements come from two separate experimental conditions, which allows for the direct estimation of drug efficacy and reservoir contribution rates, two parameters that cannot be identified from decay-phase data alone. A Markov-Chain Monte-Carlo method is used to estimate the model parameter values, with initial estimates obtained using nonlinear least-squares methods. The posterior distributions of the parameter estimates are reported and compared for all patients.

  9. Kinetic modelling of anaerobic hydrolysis of solid wastes, including disintegration processes

    Energy Technology Data Exchange (ETDEWEB)

    García-Gen, Santiago [Department of Chemical Engineering, Institute of Technology, University of Santiago de Compostela, 15782 Santiago de Compostela (Spain); Sousbie, Philippe; Rangaraj, Ganesh [INRA, UR50, Laboratoire de Biotechnologie de l’Environnement, Avenue des Etangs, Narbonne F-11100 (France); Lema, Juan M. [Department of Chemical Engineering, Institute of Technology, University of Santiago de Compostela, 15782 Santiago de Compostela (Spain); Rodríguez, Jorge, E-mail: jrodriguez@masdar.ac.ae [Department of Chemical Engineering, Institute of Technology, University of Santiago de Compostela, 15782 Santiago de Compostela (Spain); Institute Centre for Water and Environment (iWater), Masdar Institute of Science and Technology, PO Box 54224 Abu Dhabi (United Arab Emirates); Steyer, Jean-Philippe; Torrijos, Michel [INRA, UR50, Laboratoire de Biotechnologie de l’Environnement, Avenue des Etangs, Narbonne F-11100 (France)

    2015-01-15

    Highlights: • Fractionation of solid wastes into readily and slowly biodegradable fractions. • Kinetic coefficients estimation from mono-digestion batch assays. • Validation of kinetic coefficients with a co-digestion continuous experiment. • Simulation of batch and continuous experiments with an ADM1-based model. - Abstract: A methodology to estimate disintegration and hydrolysis kinetic parameters of solid wastes and validate an ADM1-based anaerobic co-digestion model is presented. Kinetic parameters of the model were calibrated from batch reactor experiments treating individually fruit and vegetable wastes (among other residues) following a new protocol for batch tests. In addition, decoupled disintegration kinetics for readily and slowly biodegradable fractions of solid wastes was considered. Calibrated parameters from batch assays of individual substrates were used to validate the model for a semi-continuous co-digestion operation treating simultaneously 5 fruit and vegetable wastes. The semi-continuous experiment was carried out in a lab-scale CSTR reactor for 15 weeks at organic loading rate ranging between 2.0 and 4.7 g VS/L d. The model (built in Matlab/Simulink) fit to a large extent the experimental results in both batch and semi-continuous mode and served as a powerful tool to simulate the digestion or co-digestion of solid wastes.

  10. A void ratio dependent water retention curve model including hydraulic hysteresis

    Directory of Open Access Journals (Sweden)

    Pasha Amin Y.

    2016-01-01

    Full Text Available Past experimental evidence has shown that Water Retention Curve (WRC evolves with mechanical stress and structural changes in soil matrix. Models currently available in the literature for capturing the volume change dependency of WRC are mainly empirical in nature requiring an extensive experimental programme for parameter identification which renders them unsuitable for practical applications. In this paper, an analytical model for the evaluation of the void ratio dependency of WRC in deformable porous media is presented. The approach proposed enables quantification of the dependency of WRC on void ratio solely based on the form of WRC at the reference void ratio and requires no additional parameters. The effect of hydraulic hysteresis on the evolution process is also incorporated in the model, an aspect rarely addressed in the literature. Expressions are presented for the evolution of main and scanning curves due to loading and change in the hydraulic path from scanning to main wetting/drying and vice versa as well as the WRC parameters such as air entry value, air expulsion value, pore size distribution index and slope of the scanning curve. The model is validated using experimental data on compacted and reconstituted soils subjected to various hydro-mechanical paths. Good agreement is obtained between model predictions and experimental data in all the cases considered.

  11. A discrete model for the apparent viscosity of polydisperse suspensions including maximum packing fraction

    CERN Document Server

    Dörr, Aaron; Mehdizadeh, Amirfarhang

    2012-01-01

    Based on the notion of a construction process consisting of the stepwise addition of particles to the pure fluid, a discrete model for the apparent viscosity as well as for the maximum packing fraction of polydisperse suspensions of spherical, non-colloidal particles is derived. The model connects the approaches by Bruggeman and Farris and is valid for large size ratios of consecutive particle classes during the construction process. Furthermore, a new general form of the well-known Krieger equation allowing for the choice of a second-order Taylor coefficient for the volume fraction is proposed and then applied as a monodisperse reference equation in the course of polydisperse modeling. By applying the polydisperse viscosity model to two different particle size distributions (Rosin-Rammler and uniform distribution), the influence of polydispersity on the apparent viscosity is examined. The extension of the model to the case of small size ratios as well as to the inclusion of shear rate effects is left for fut...

  12. Simplified analytical modeling of the normal hole erosion test; Modelado analitico simplificado del ensayo normal de ersoion de tubo

    Energy Technology Data Exchange (ETDEWEB)

    Khamlichi, A.; Bezzazi, M.; El Bakkali, L.; Jabbouri, A.; Kissi, B.; Yakhlef, F.; Parron Vera, M. A.; Rubio Cintas, M. D.; Castillo Lopez, O.

    2009-07-01

    The role erosion test was developed in order to study erosion phenomenon which occurs in cracks appearing in hydraulic infrastructures such as dams. This test enables describing experimentally the erosive characteristics of soils by means of an index which is called erosion rate and a critical tension which indicates the threshold of surface erosion initiation. The objective of this work is to five modelling of this experiment by means of a simplified analytical approach. The erosion law is derived by taking into account the flow regime. This law shows that the erosion occurring in the tube is controlled by a first order dynamics where only two parameters are involved: the characteristic's time linked to the erosion rate and the stress shear threshold for which erosion begins to develop. (Author) 5 refs.

  13. Mathematical model and manufacture programming of loxodromic-type normal circular-arc spiral bevel gear

    Science.gov (United States)

    Duan, Zhenyun; Chen, Houjun; Ju, Zhilan; Liu, Jian

    2012-09-01

    In this paper, loxodromic-type normal circulararc spiral bevel gear is proposed as a novel application of the circular-arc tooth profile at the gear transmission with intersecting axes. Based on the principle of molding-surface conjugation, the study develops a mathematical model for the tooth alignment curve and the computational flow at the design stage to enable the generation of the tooth surface. Machining of the tooth surface is then carried out to determine the interference-free tool path of the numerical control (NC). Moreover, a pair of loxodromic-type normal circular-arc spiral bevel gears is manufactured on computer numerical control (CNC) machine tools. The proposed theory and method are experimentally investigated, and the obtained results primarily reflect the superior performance of the proposed novel gear.

  14. A review of shear strength models for rock joints subjected to constant normal stiffness

    Directory of Open Access Journals (Sweden)

    Sivanathan Thirukumaran

    2016-06-01

    Full Text Available The typical shear behaviour of rough joints has been studied under constant normal load/stress (CNL boundary conditions, but recent studies have shown that this boundary condition may not replicate true practical situations. Constant normal stiffness (CNS is more appropriate to describe the stress–strain response of field joints since the CNS boundary condition is more realistic than CNL. The practical implications of CNS are movements of unstable blocks in the roof or walls of an underground excavation, reinforced rock wedges sliding in a rock slope or foundation, and the vertical movement of rock-socketed concrete piles. In this paper, the highlights and limitations of the existing models used to predict the shear strength/behaviour of joints under CNS conditions are discussed in depth.

  15. Improving normal tissue complication probability models: the need to adopt a "data-pooling" culture.

    Science.gov (United States)

    Deasy, Joseph O; Bentzen, Søren M; Jackson, Andrew; Ten Haken, Randall K; Yorke, Ellen D; Constine, Louis S; Sharma, Ashish; Marks, Lawrence B

    2010-03-01

    Clinical studies of the dependence of normal tissue response on dose-volume factors are often confusingly inconsistent, as the QUANTEC reviews demonstrate. A key opportunity to accelerate progress is to begin storing high-quality datasets in repositories. Using available technology, multiple repositories could be conveniently queried, without divulging protected health information, to identify relevant sources of data for further analysis. After obtaining institutional approvals, data could then be pooled, greatly enhancing the capability to construct predictive models that are more widely applicable and better powered to accurately identify key predictive factors (whether dosimetric, image-based, clinical, socioeconomic, or biological). Data pooling has already been carried out effectively in a few normal tissue complication probability studies and should become a common strategy.

  16. IMPROVING NORMAL TISSUE COMPLICATION PROBABILITY MODELS: THE NEED TO ADOPT A “DATA-POOLING” CULTURE

    Science.gov (United States)

    Deasy, Joseph O.; Bentzen, Søren M.; Jackson, Andrew; Ten Haken, Randall K.; Yorke, Ellen D.; Constine, Louis S.; Sharma, Ashish; Marks, Lawrence B.

    2010-01-01

    Clinical studies of the dependence of normal tissue response on dose-volume factors are often confusingly inconsistent, as the QUANTEC reviews demonstrate. A key opportunity to accelerate progress is to begin storing high-quality datasets in repositories. Using available technology, multiple repositories could be conveniently queried, without divulging protected health information, to identify relevant sources of data for further analysis. After obtaining institutional approvals, data could then be pooled, greatly enhancing the capability to construct predictive models that are more widely applicable and better powered to accurately identify key predictive factors (whether dosimetric, image-based, clinical, socioeconomic, or biological). Data pooling has already been carried out effectively in a few normal tissue complication probability studies and should become a common strategy. PMID:20171511

  17. A Simple Model of Fields Including the Strong or Nuclear Force and a Cosmological Speculation

    Directory of Open Access Journals (Sweden)

    David L. Spencer

    2016-10-01

    Full Text Available Reexamining the assumptions underlying the General Theory of Relativity and calling an object's gravitational field its inertia, and acceleration simply resistance to that inertia, yields a simple field model where the potential (kinetic energy of a particle at rest is its capacity to move itself when its inertial field becomes imbalanced. The model then attributes electromagnetic and strong forces to the effects of changes in basic particle shape. Following up on the model's assumption that the relative intensity of a particle's gravitational field is always inversely related to its perceived volume and assuming that all black holes spin, may create the possibility of a cosmic rebound where a final spinning black hole ends with a new Big Bang.

  18. Numerical models of single- and double-negative metamaterials including viscous and thermal losses

    DEFF Research Database (Denmark)

    Cutanda Henriquez, Vicente; Sánchez-Dehesa, José

    2017-01-01

    Negative index acoustic metamaterials are artificial structures made of subwavelength units arranged in a lattice, whose effective acoustic parameters, bulk modulus and mass density, can be negative. In these materials, sound waves propagate inside the periodic structure, assumed rigid, showing...... extraordinary properties. We are interested in two particular cases: a double-negative metamaterial, where both parameters are negative at some frequencies, and a single-negative metamaterial with negative bulk modulus within a broader frequency band. In previous research involving the double......-negative metamaterial, numerical models with viscous and thermal losses were used to explain that the extraordinary behavior, predicted by analytical models and numerical simulations with no losses, disappeared when the metamaterial was measured in physical setups. The improvement of the models is allowing now a more...

  19. Damped structural dynamics models of large wind-turbine blades including material and structural damping

    Energy Technology Data Exchange (ETDEWEB)

    Chortis, D I; Chrysochoidis, N A; Saravanos, D A [Department of Mechanical Engineering and Aeronautics, University of Patras, Patras 26500 (Greece)

    2007-07-15

    The paper presents a brief description of composite damping mechanics for blade sections of arbitrary lamination and geometry. A damped 3-D shear beam element is presented enabling the assembly of damped structural dynamic models of blades with hollow multi-cell tubular laminated sections. Emphasis is placed to the inclusion of composite material coupling effects, first in the blade section stiffness and damping matrices and finally into the stiffness and damping matrices of the finite element. Evaluations of the beam element are presented, to quantify the material coupling effect on composite beams of simple box sections. Correlations between predicted and measured modal frequencies and damping values in small model Glass/Epoxy are also shown. Finally, the damped modal characteristics of a 35m realistic wind-turbine blade model design, are predicted.

  20. A study of a hamiltonian model for martensitic phase transformations including microkinetic energy

    CERN Document Server

    Theil, F

    1998-01-01

    How can a system in a macroscopically stable state explore energetically more favorable states, which are far away from the current equilibrium state? Based on continuum mechanical considerations we derive a Boussinesq-type equation which models the dynamics of martensitic phase transformations. The solutions of the system, which we refer to as microkinetically regularized wave equation exhibit strong oscillations after short times, thermalization can be confirmed. That means that macroscopic fluctuations of the solutions decay at the benefit of microscopic fluctuations. First analytical and numerical results on the propagation of phase boundaries and thermalization effects are presented. Despite the fact that model is conservative, it exhibits the hysteretic behavior. Such a behavior is usually interpreted in macroscopic models in terms of dissipative threshold which the driving force has to overcome to ensure that the phase transformation proceeds. The threshold value depends on the amount of the transforme...

  1. Hybrid Model Representation of a TLP Including Flexible Topsides in Non-Linear Regular Waves

    Directory of Open Access Journals (Sweden)

    Christof Wehmeyer

    2014-08-01

    Full Text Available The rising demand for renewable energy solutions is forcing the established industries to expand and continue evolving. For the wind energy sector, the vast resources in deep sea locations have encouraged research towards the installation of turbines in deeper waters. One of the most promising technologies able to solve this challenge is the floating wind turbine foundation. For the ultimate limit state, where higher order wave loads have a significant influence, a design tool that couples non-linear excitations with structural dynamics is required. To properly describe the behavior of such a structure, a numerical model is proposed and validated by physical test results. The model is applied to a case study of a tension leg platform with a flexible topside mimicking the tower and a lumped mass mimicking the rotor-nacelle assembly. The model is additionally compared to current commercial software, where the need for the coupled higher order dynamics proposed in this paper becomes evident.

  2. Generalization of the normal-exponential model: exploration of a more accurate parametrisation for the signal distribution on Illumina BeadArrays.

    Science.gov (United States)

    Plancade, Sandra; Rozenholc, Yves; Lund, Eiliv

    2012-12-11

    Illumina BeadArray technology includes non specific negative control features that allow a precise estimation of the background noise. As an alternative to the background subtraction proposed in BeadStudio which leads to an important loss of information by generating negative values, a background correction method modeling the observed intensities as the sum of the exponentially distributed signal and normally distributed noise has been developed. Nevertheless, Wang and Ye (2012) display a kernel-based estimator of the signal distribution on Illumina BeadArrays and suggest that a gamma distribution would represent a better modeling of the signal density. Hence, the normal-exponential modeling may not be appropriate for Illumina data and background corrections derived from this model may lead to wrong estimation. We propose a more flexible modeling based on a gamma distributed signal and a normal distributed background noise and develop the associated background correction, implemented in the R-package NormalGamma. Our model proves to be markedly more accurate to model Illumina BeadArrays: on the one hand, it is shown on two types of Illumina BeadChips that this model offers a more correct fit of the observed intensities. On the other hand, the comparison of the operating characteristics of several background correction procedures on spike-in and on normal-gamma simulated data shows high similarities, reinforcing the validation of the normal-gamma modeling. The performance of the background corrections based on the normal-gamma and normal-exponential models are compared on two dilution data sets, through testing procedures which represent various experimental designs. Surprisingly, we observe that the implementation of a more accurate parametrisation in the model-based background correction does not increase the sensitivity. These results may be explained by the operating characteristics of the estimators: the normal-gamma background correction offers an improvement

  3. A biomechanical model of the face including muscles for the prediction of deformations during speech production

    CERN Document Server

    Groleau, Julie; Marecaux, Christophe; Payrard, Natacha; Segaud, Brice; Rochette, Michel; Perrier, Pascal; Payan, Yohan

    2008-01-01

    A 3D biomechanical finite element model of the face is presented. Muscles are represented by piece-wise uniaxial tension cable elements linking the insertion points. Such insertion points are specific entities differing from nodes of the finite element mesh, which makes possible to change either the mesh or the muscle implementation totally independently of each other. Lip/teeth and upper lip/lower lip contacts are also modeled. Simulations of smiling and of an Orbicularis Oris activation are presented and interpreted. The importance of a proper account of contacts and of an accurate anatomical description is shown

  4. European air quality modelled by CAMx including the volatility basis set scheme

    Directory of Open Access Journals (Sweden)

    G. Ciarelli

    2015-12-01

    Full Text Available Four periods of EMEP (European Monitoring and Evaluation Programme intensive measurement campaigns (June 2006, January 2007, September–October 2008 and February–March 2009 were modelled using the regional air quality model CAMx with VBS (Volatility Basis Set approach for the first time in Europe within the framework of the EURODELTA-III model intercomparison exercise. More detailed analysis and sensitivity tests were performed for the period of February–March 2009 and June 2006 to investigate the uncertainties in emissions as well as to improve the modelling of organic aerosols (OA. Model performance for selected gas phase species and PM2.5 was evaluated using the European air quality database Airbase. Sulfur dioxide (SO2 and ozone (O3 were found to be overestimated for all the four periods with O3 having the largest mean bias during June 2006 and January–February 2007 periods (8.93 and 12.30 ppb mean biases, respectively. In contrast, nitrogen dioxide (NO2 and carbon monoxide (CO were found to be underestimated for all the four periods. CAMx reproduced both total concentrations and monthly variations of PM2.5 very well for all the four periods with average biases ranging from −2.13 to 1.04 μg m-3. Comparisons with AMS (Aerosol Mass Spectrometer measurements at different sites in Europe during February–March 2009, showed that in general the model over-predicts the inorganic aerosol fraction and under-predicts the organic one, such that the good agreement for PM2.5 is partly due to compensation of errors. The effect of the choice of volatility basis set scheme (VBS on OA was investigated as well. Two sensitivity tests with volatility distributions based on previous chamber and ambient measurements data were performed. For February–March 2009 the chamber-case reduced the total OA concentrations by about 43 % on average. On the other hand, a test based on ambient measurement data increased OA concentrations by about 47 % for the same

  5. Viscoelastic Model of Cross-Linked Polyethylene Including Effects of Temperature and Crystallinity

    Science.gov (United States)

    Olasz, L.; Gudmundson, P.

    2005-12-01

    Characterization of the mechanical behavior of cross-linked polyethylene (XLPE) commonly used in high voltage cable insulation was performed by an extensive set of isothermal uniaxial tensile relaxation tests. Tensile relaxation experiments were complemented by pressure-volume-temperature experiments as well as density and crystallinity measurements. Based on the experimental results, a viscoelastic power law model with four parameters was formulated, incorporating temperature and crystallinity dependence. It was found that a master curve can be developed by both horizontal and vertical shifting of the relaxation curves. The model was evaluated by making comparisons of the predicted stress responses with the measured responses in relaxation tests with transient temperature histories.

  6. Piecewise log-normal approximation of size distributions for aerosol modelling

    Directory of Open Access Journals (Sweden)

    K. von Salzen

    2006-01-01

    Full Text Available An efficient and accurate method for the representation of particle size distributions in atmospheric models is proposed. The method can be applied, but is not necessarily restricted, to aerosol mass and number size distributions. A piecewise log-normal approximation of the number size distribution within sections of the particle size spectrum is used. Two of the free parameters of the log-normal approximation are obtained from the integrated number and mass concentration in each section. The remaining free parameter is prescribed. The method is efficient in a sense that only relatively few calculations are required for applications of the method in atmospheric models. Applications of the method in simulations of particle growth by condensation and simulations with a single column model for nucleation, condensation, gravitational settling, wet deposition, and mixing are described. The results are compared to results from simulations employing single- and double-moment bin methods that are frequently used in aerosol modelling. According to these comparisons, the accuracy of the method is noticeably higher than the accuracy of the other methods.

  7. Implementation of Combined Feather and Surface-Normal Ice Growth Models in LEWICE/X

    Science.gov (United States)

    Velazquez, M. T.; Hansman, R. J., Jr.

    1995-01-01

    Experimental observations have shown that discrete rime ice growths called feathers, which grow in approximately the direction of water droplet impingement, play an important role in the growth of ice on accreting surfaces for some thermodynamic conditions. An improved physical model of ice accretion has been implemented in the LEWICE 2D panel-based ice accretion code maintained by the NASA Lewis Research Center. The LEWICE/X model of ice accretion explicitly simulates regions of feather growth within the framework of the LEWICE model. Water droplets impinging on an accreting surface are withheld from the normal LEWICE mass/energy balance and handled in a separate routine; ice growth resulting from these droplets is performed with enhanced convective heat transfer approximately along droplet impingement directions. An independent underlying ice shape is grown along surface normals using the unmodified LEWICE method. The resulting dual-surface ice shape models roughness-induced feather growth observed in icing wind tunnel tests. Experiments indicate that the exact direction of feather growth is dependent on external conditions. Data is presented to support a linear variation of growth direction with temperature and cloud water content. Test runs of LEWICE/X indicate that the sizes of surface regions containing feathers are influenced by initial roughness element height. This suggests that a previous argument that feather region size is determined by boundary layer transition may be incorrect. Simulation results for two typical test cases give improved shape agreement over unmodified LEWICE.

  8. Performance of an inverted pendulum model directly applied to normal human gait.

    Science.gov (United States)

    Buczek, Frank L; Cooney, Kevin M; Walker, Matthew R; Rainbow, Michael J; Concha, M Cecilia; Sanders, James O

    2006-03-01

    In clinical gait analysis, we strive to understand contributions to body support and propulsion as this forms a basis for treatment selection, yet the relative importance of gravitational forces and joint powers can be controversial even for normal gait. We hypothesized that an inverted pendulum model, propelled only by gravity, would be inadequate to predict velocities and ground reaction forces during gait. Unlike previous ballistic and passive dynamic walking studies, we directly compared model predictions to gait data for 24 normal children. We defined an inverted pendulum from the average center-of-pressure to the instantaneous center-of-mass, and derived equations of motion during single support that allowed a telescoping action. Forward and inverse dynamics predicted pendulum velocities and ground reaction forces, and these were statistically and graphically compared to actual gait data for identical strides. Results of forward dynamics replicated those in the literature, with reasonable predictions for velocities and anterior ground reaction forces, but poor predictions for vertical ground reaction forces. Deviations from actual values were explained by joint powers calculated for these subjects. With a telescoping action during inverse dynamics, predicted vertical forces improved dramatically and gained a dual-peak pattern previously missing in the literature, yet expected for normal gait. These improvements vanished when telescoping terms were set to zero. Because this telescoping action is difficult to explain without muscle activity, we believe these results support the need for both gravitational forces and joint powers in normal gait. Our approach also begins to quantify the relative contributions of each.

  9. Normal and Fibrotic Rat Livers Demonstrate Shear Strain Softening and Compression Stiffening: A Model for Soft Tissue Mechanics.

    Science.gov (United States)

    Perepelyuk, Maryna; Chin, LiKang; Cao, Xuan; van Oosten, Anne; Shenoy, Vivek B; Janmey, Paul A; Wells, Rebecca G

    2016-01-01

    Tissues including liver stiffen and acquire more extracellular matrix with fibrosis. The relationship between matrix content and stiffness, however, is non-linear, and stiffness is only one component of tissue mechanics. The mechanical response of tissues such as liver to physiological stresses is not well described, and models of tissue mechanics are limited. To better understand the mechanics of the normal and fibrotic rat liver, we carried out a series of studies using parallel plate rheometry, measuring the response to compressive, extensional, and shear strains. We found that the shear storage and loss moduli G' and G" and the apparent Young's moduli measured by uniaxial strain orthogonal to the shear direction increased markedly with both progressive fibrosis and increasing compression, that livers shear strain softened, and that significant increases in shear modulus with compressional stress occurred within a range consistent with increased sinusoidal pressures in liver disease. Proteoglycan content and integrin-matrix interactions were significant determinants of liver mechanics, particularly in compression. We propose a new non-linear constitutive model of the liver. A key feature of this model is that, while it assumes overall liver incompressibility, it takes into account water flow and solid phase compressibility. In sum, we report a detailed study of non-linear liver mechanics under physiological strains in the normal state, early fibrosis, and late fibrosis. We propose a constitutive model that captures compression stiffening, tension softening, and shear softening, and can be understood in terms of the cellular and matrix components of the liver.

  10. The island coalescence problem: scaling of reconnection in extended fluid models including higher-order moments

    CERN Document Server

    Ng, Jonathan; Hakim, Ammar; Bhattacharjee, Amitava; Stanier, Adam; Daughton, William; Wang, Liang; Germaschewski, Kai

    2015-01-01

    As modeling of collisionless magnetic reconnection in most space plasmas with realistic parameters is beyond the capability of today's simulations, due to the separation between global and kinetic length scales, it is important to establish scaling relations in model problems so as to extrapolate to realistic scales. Recently, large scale particle-in-cell (PIC) simulations of island coalescence have shown that the time averaged reconnection rate decreases with system size, while fluid systems at such large scales in the Hall regime have not been studied. Here we perform the complementary resistive MHD, Hall MHD and two fluid simulations using a ten-moment model with the same geometry. In contrast to the standard Harris sheet reconnection problem, Hall MHD is insufficient to capture the physics of the reconnection region. Additionally, motivated by the results of a recent set of hybrid simulations which show the importance of ion kinetics in this geometry, we evaluate the efficacy of the ten-moment model in re...

  11. Situational effects of the school factors included in the dynamic model of educational effectiveness

    NARCIS (Netherlands)

    Creerners, Bert; Kyriakides, Leonidas

    2009-01-01

    We present results of a longitudinal study in which 50 schools, 113 classes and 2,542 Cypriot primary students participated. We tested the validity of the dynamic model of educational effectiveness and especially its assumption that the impact of school factors depends on the current situation of th

  12. Turbulent combustion modelling of a confined premixed jet flame including heat loss effects using tabulated chemistry

    NARCIS (Netherlands)

    Gövert, S.; Mira, D.; Kok, J.B.W.; Vázquez, M.; Houzeaux, G.

    2015-01-01

    The present work addresses the coupling of a flamelet database, to a low-Mach approximation of the Navier–Stokes equations using scalar controlling variables. The model is characterized by the chemistry tabulation based on laminar premixed flamelets in combination with an optimal choice of the react

  13. Kinetic modelling of anaerobic hydrolysis of solid wastes, including disintegration processes.

    Science.gov (United States)

    García-Gen, Santiago; Sousbie, Philippe; Rangaraj, Ganesh; Lema, Juan M; Rodríguez, Jorge; Steyer, Jean-Philippe; Torrijos, Michel

    2015-01-01

    A methodology to estimate disintegration and hydrolysis kinetic parameters of solid wastes and validate an ADM1-based anaerobic co-digestion model is presented. Kinetic parameters of the model were calibrated from batch reactor experiments treating individually fruit and vegetable wastes (among other residues) following a new protocol for batch tests. In addition, decoupled disintegration kinetics for readily and slowly biodegradable fractions of solid wastes was considered. Calibrated parameters from batch assays of individual substrates were used to validate the model for a semi-continuous co-digestion operation treating simultaneously 5 fruit and vegetable wastes. The semi-continuous experiment was carried out in a lab-scale CSTR reactor for 15 weeks at organic loading rate ranging between 2.0 and 4.7 gVS/Ld. The model (built in Matlab/Simulink) fit to a large extent the experimental results in both batch and semi-continuous mode and served as a powerful tool to simulate the digestion or co-digestion of solid wastes.

  14. New phases in an extended Hubbard model explicitly including atomic polarizabilities

    NARCIS (Netherlands)

    Brink, van de J.; Meinders, M.B.J.; Lorenzana, J.; Eder, R.; Sawatzky, G.A.

    1996-01-01

    We consider the influence of a nearest-neighbor Coulomb interaction in an extended Hubbard model and introduce a new interaction term which simulates atomic polarizabilities. This has the effect of screening the on-site Coulomb interaction for charged excitations, unlike a neighbor Coulomb interacti

  15. Modeling of etch profile evolution including wafer charging effects using self consistent ion fluxes

    Energy Technology Data Exchange (ETDEWEB)

    Hoekstra, R.J.; Kushner, M.J. [Univ. of Illinois, Urbana, IL (United States). Dept. of Electrical and Computer Engineering

    1996-12-31

    As high density plasma reactors become more predominate in industry, the need has intensified for computer aided design tools which address both equipment issues such as ion flux uniformity onto the water and process issues such etch feature profile evolution. A hierarchy of models has been developed to address these issues with the goal of producing a comprehensive plasma processing design capability. The Hybrid Plasma Equipment Model (HPEM) produces ion and neutral densities, and electric fields in the reactor. The Plasma Chemistry Monte Carlo Model (PCMC) determines the angular and energy distributions of ion and neutral fluxes to the wafer using species source functions, time dependent bulk electric fields, and sheath potentials from the HPEM. These fluxes are then used by the Monte Carlo Feature Profile Model (MCFP) to determine the time evolution of etch feature profiles. Using this hierarchy, the effects of physical modifications of the reactor, such as changing wafer clamps or electrode structures, on etch profiles can be evaluated. The effects of wafer charging on feature evolution are examined by calculating the fields produced by the charge deposited by ions and electrons within the features. The effect of radial variations and nonuniformity in angular and energy distribution of the reactive fluxes on feature profiles and feature charging will be discussed for p-Si etching in inductively-coupled plasma (ICP) sustained in chlorine gas mixtures. The effects of over- and under-wafer topography on etch profiles will also be discussed.

  16. Surface-wave mode coupling : modelling and inverting waveforms including body-wave phases

    NARCIS (Netherlands)

    Marquering, H.A.

    1996-01-01

    This thesis is concerned with a similar problem as addressed by Li & Tanimoto (1993) in the surfacewave mode approach. In this thesis it is shown that surface-wave mode coupling is required when body-wave phases in laterally heterogeneous media are modelled by surface-wave mode summation. An efficie

  17. The island coalescence problem: Scaling of reconnection in extended fluid models including higher-order moments

    Energy Technology Data Exchange (ETDEWEB)

    Ng, Jonathan; Huang, Yi-Min; Hakim, Ammar; Bhattacharjee, A. [Center for Heliophysics, Princeton Plasma Physics Laboratory, Princeton, New Jersey 08540 (United States); Stanier, Adam; Daughton, William [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Wang, Liang; Germaschewski, Kai [Space Science Center and Physics Department, University of New Hampshire, Durham, New Hampshire 03824 (United States)

    2015-11-15

    As modeling of collisionless magnetic reconnection in most space plasmas with realistic parameters is beyond the capability of today's simulations, due to the separation between global and kinetic length scales, it is important to establish scaling relations in model problems so as to extrapolate to realistic scales. Recently, large scale particle-in-cell simulations of island coalescence have shown that the time averaged reconnection rate decreases with system size, while fluid systems at such large scales in the Hall regime have not been studied. Here, we perform the complementary resistive magnetohydrodynamic (MHD), Hall MHD, and two fluid simulations using a ten-moment model with the same geometry. In contrast to the standard Harris sheet reconnection problem, Hall MHD is insufficient to capture the physics of the reconnection region. Additionally, motivated by the results of a recent set of hybrid simulations which show the importance of ion kinetics in this geometry, we evaluate the efficacy of the ten-moment model in reproducing such results.

  18. Analytical and numerical modelling of thermoviscous shocks in their interactions in nonlinear fluids including dissipation

    DEFF Research Database (Denmark)

    Rasmussen, Anders Rønne; Sørensen, Mads Peter; Gaididei, Yuri Borisovich

    2010-01-01

    A wave equation, that governs finite amplitude acoustic disturbances in a thermoviscous Newtonian fluid, and includes nonlinear terms up to second order, is proposed. The equation preserves the Hamiltonian structure of the fundamental fluid dynamical equations in the non dissipative limit. An exact...

  19. Damage constitutive model for strain-softening rock based on normal distribution and its parameter determination

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Firstly, using the damage model for rock based on Lemaitre hypothesis about strain equivalence, a new technique for measuring strength of rock micro-cells by adopting the Mohr-Coulomb criterion was developed, and a statistical damage evolution equation was established based on the property that strength of micro-cells is consistent with normal distribution function, through discussing the characteristics of random distributions for strength of micro-cells, then a statistical damage constitutive model that can simulate the full process of rock strain softening under specific confining pressure was set up. Secondly, a new method to determine the model parameters which can be applied to the situations under different confining pressures was proposed, by deeply studying the relations between the model parameters and characteristic parameters of the full stress-strain curve under different confining pressures. Therefore, a unified statistical damage constitutive model for rock softening which can reflect the effect of different confining pressures was set up. This model makes the physical property of model parameters explicit, contains only conventional mechanical parameters, and leads its application more convenient. Finally, the rationality of this model and its parameters-determining method were identified via comparative analyses between theoretical and experimental curves.

  20. Microscopic prediction of speech recognition for listeners with normal hearing in noise using an auditory model.

    Science.gov (United States)

    Jürgens, Tim; Brand, Thomas

    2009-11-01

    This study compares the phoneme recognition performance in speech-shaped noise of a microscopic model for speech recognition with the performance of normal-hearing listeners. "Microscopic" is defined in terms of this model twofold. First, the speech recognition rate is predicted on a phoneme-by-phoneme basis. Second, microscopic modeling means that the signal waveforms to be recognized are processed by mimicking elementary parts of human's auditory processing. The model is based on an approach by Holube and Kollmeier [J. Acoust. Soc. Am. 100, 1703-1716 (1996)] and consists of a psychoacoustically and physiologically motivated preprocessing and a simple dynamic-time-warp speech recognizer. The model is evaluated while presenting nonsense speech in a closed-set paradigm. Averaged phoneme recognition rates, specific phoneme recognition rates, and phoneme confusions are analyzed. The influence of different perceptual distance measures and of the model's a-priori knowledge is investigated. The results show that human performance can be predicted by this model using an optimal detector, i.e., identical speech waveforms for both training of the recognizer and testing. The best model performance is yielded by distance measures which focus mainly on small perceptual distances and neglect outliers.

  1. Roughing It Up: Including Jump Components in the Measurement, Modeling and Forecasting of Return Volatility

    DEFF Research Database (Denmark)

    Bollerslev, Tim; Andersen, Torben G.; Diebold, Francis X.

    A rapidly growing literature has documented important improvements in financial return volatility measurement and forecasting via use of realized variation measures constructed from high-frequency returns coupled with simple modeling procedures. Building on recent theoretical results in Barndorff...... bond yield, we find that jumps are both highly prevalent and distinctly less persistent than the continuous sample path variation process. Moreover, many jumps appear directly associated with specific macroeconomic news announcements. Separating jump from non-jump movements in a simple...... but sophisticated volatility forecasting model, we find that almost all of the predictability in daily, weekly, and monthly return volatilities comes from the non-jump component. Our results thus set the stage for a number of interesting future econometric developments and important financial applications...

  2. Ion-biomolecule collisions studied within the independent atom model including geometric screening corrections

    Science.gov (United States)

    Lüdde, H. J.; Achenbach, A.; Kalkbrenner, T.; Jankowiak, H. C.; Kirchner, T.

    2016-05-01

    A recently introduced model to account for geometric screening corrections in an independent-atom-model description of ion-molecule collisions is applied to proton collisions from amino acids and DNA and RNA nucleobases. The correction coefficients are obtained from using a pixel counting method (PCM) for the exact calculation of the effective cross sectional area that emerges when the molecular cross section is pictured as a structure of (overlapping) atomic cross sections. This structure varies with the relative orientation of the molecule with respect to the projectile beam direction and, accordingly, orientation-independent total cross sections are obtained from averaging the pixel count over many orientations. We present net capture and net ionization cross sections over wide ranges of impact energy and analyze the strength of the screening effect by comparing the PCM results with Bragg additivity rule cross sections and with experimental data where available. Work supported by NSERC, Canada.

  3. Mathematical analysis of a two-dimensional population model of metastatic growth including angiogenesis

    CERN Document Server

    Benzekry, Sebastien

    2010-01-01

    Angiogenesis is a key process in the tumoral growth which allows the cancerous tissue to impact on its vasculature in order to improve the nutrient's supply and the metastatic process. In this paper, we introduce a model for the density of metastasis which takes into account for this feature. It is a two dimensional structured equation with a vanishing velocity field and a source term on the boundary. We present here the mathematical analysis of the model, namely the well-posedness of the equation and the asymptotic behavior of the solutions, whose natural regularity led us to investigate some basic properties of the space $\\Wd(\\Om)=\\{V\\in L^1;\\;\\div(GV)\\in L^1\\}$, where $G$ is the velocity field of the equation.

  4. A model for thermal oxidation of Si and SiC including material expansion

    Energy Technology Data Exchange (ETDEWEB)

    Christen, T., E-mail: thomas.christen@ch.abb.com; Ioannidis, A. [ABB Corporate Research, Segelhofstrasse 1K, CH-5405 Baden (Switzerland); Winkelmann, C. [ETH Zürich, Seminar for Applied Mathematics, Rämistrasse 101, CH-8092 Zürich (Switzerland)

    2015-02-28

    A model based on drift-diffusion-reaction kinetics for Si and SiC oxidation is discussed, which takes the material expansion into account with an additional convection term. The associated velocity field is determined self-consistently from the local reaction rate. The approach allows a calculation of the densities of volatile species in an nm-resolution at the oxidation front. The model is illustrated with simulation results for the growth and impurity redistribution during Si oxidation and for carbon and silicon emission during SiC oxidation. The approach can be useful for the prediction of Si and/or C interstitial distribution, which is particularly relevant for the quality of metal-oxide-semiconductor electronic devices.

  5. A roller chain drive model including contact with guide-bars

    DEFF Research Database (Denmark)

    Pedersen, Sine Leergaard; Hansen, John Michael; Ambrósio, J. A. C.

    2004-01-01

    and continuous force methods, respectively. In the unilateral constraint methodology the kinematic constraints are introduced in the system anytime a contact between the rollers and the sprockets is detected. The condition for the constraint addition is based on the relative distance between the roller centre...... and the sprocket centre, i.e. a constraint is added when such distance is less than the pitch radius. The unilateral kinematic constraint is removed when its associated constraint reaction force, applied on the roller, is in the direction of the root of the sprocket teeth. In order to improve the numerical...... as continuous force. The model of the roller-chain drive now proposed departs from an earlier model where two contact/impact methods are proposed to describe the contact between the rollers of the chain and the teeth of the sprockets. These different formulations are based on unilateral constraints...

  6. Roughing It Up: Including Jump Components in the Measurement, Modeling and Forecasting of Return Volatility

    DEFF Research Database (Denmark)

    Bollerslev, Tim; Andersen, Torben G.; Diebold, Francis X.

    -Nielsen and Shephard (2004a, 2005) for related bi-power variation measures, the present paper provides a practical and robust framework for non-parametrically measuring the jump component in asset return volatility. In an application to the DM/$ exchange rate, the S&P500 market index, and the 30-year U.S. Treasury......A rapidly growing literature has documented important improvements in financial return volatility measurement and forecasting via use of realized variation measures constructed from high-frequency returns coupled with simple modeling procedures. Building on recent theoretical results in Barndorff...... but sophisticated volatility forecasting model, we find that almost all of the predictability in daily, weekly, and monthly return volatilities comes from the non-jump component. Our results thus set the stage for a number of interesting future econometric developments and important financial applications...

  7. Micromagnetic model for studies on Magnetic Tunnel Junction switching dynamics, including local current density

    Energy Technology Data Exchange (ETDEWEB)

    Frankowski, Marek, E-mail: mfrankow@agh.edu.pl; Czapkiewicz, Maciej; Skowronski, Witold; Stobiecki, Tomasz

    2014-02-15

    We present a model introducing the Landau–Lifshitz–Gilbert equation with a Slonczewski's Spin-Transfer-Torque (STT) component in order to take into account spin polarized current influence on the magnetization dynamics, which was developed as an Object Oriented MicroMagnetic Framework extension. We implement the following computations: magnetoresistance of vertical channels is calculated from the local spin arrangement, local current density is used to calculate the in-plane and perpendicular STT components as well as the Oersted field, which is caused by the vertical current flow. The model allows for an analysis of all listed components separately, therefore, the contribution of each physical phenomenon in dynamic behavior of Magnetic Tunnel Junction (MTJ) magnetization is discussed. The simulated switching voltage is compared with the experimental data measured in MTJ nanopillars.

  8. Prediction of consonant recognition in quiet for listeners with normal and impaired hearing using an auditory model.

    Science.gov (United States)

    Jürgens, Tim; Ewert, Stephan D; Kollmeier, Birger; Brand, Thomas

    2014-03-01

    Consonant recognition was assessed in normal-hearing (NH) and hearing-impaired (HI) listeners in quiet as a function of speech level using a nonsense logatome test. Average recognition scores were analyzed and compared to recognition scores of a speech recognition model. In contrast to commonly used spectral speech recognition models operating on long-term spectra, a "microscopic" model operating in the time domain was used. Variations of the model (accounting for hearing impairment) and different model parameters (reflecting cochlear compression) were tested. Using these model variations this study examined whether speech recognition performance in quiet is affected by changes in cochlear compression, namely, a linearization, which is often observed in HI listeners. Consonant recognition scores for HI listeners were poorer than for NH listeners. The model accurately predicted the speech reception thresholds of the NH and most HI listeners. A partial linearization of the cochlear compression in the auditory model, while keeping audibility constant, produced higher recognition scores and improved the prediction accuracy. However, including listener-specific information about the exact form of the cochlear compression did not improve the prediction further.

  9. Solution model of nonlinear integral adjustment including different kinds of observing data with different precisions

    Institute of Scientific and Technical Information of China (English)

    郭金运; 陶华学

    2003-01-01

    In order to process different kinds of observing data with different precisions, a new solution model of nonlinear dynamic integral least squares adjustment was put forward, which is not dependent on their derivatives. The partial derivative of each component in the target function is not computed while iteratively solving the problem. Especially when the nonlinear target function is more complex and very difficult to solve the problem, the method can greatly reduce the computing load.

  10. A Multiscale Progressive Failure Modeling Methodology for Composites that Includes Fiber Strength Stochastics

    Science.gov (United States)

    Ricks, Trenton M.; Lacy, Thomas E., Jr.; Bednarcyk, Brett A.; Arnold, Steven M.; Hutchins, John W.

    2014-01-01

    A multiscale modeling methodology was developed for continuous fiber composites that incorporates a statistical distribution of fiber strengths into coupled multiscale micromechanics/finite element (FE) analyses. A modified two-parameter Weibull cumulative distribution function, which accounts for the effect of fiber length on the probability of failure, was used to characterize the statistical distribution of fiber strengths. A parametric study using the NASA Micromechanics Analysis Code with the Generalized Method of Cells (MAC/GMC) was performed to assess the effect of variable fiber strengths on local composite failure within a repeating unit cell (RUC) and subsequent global failure. The NASA code FEAMAC and the ABAQUS finite element solver were used to analyze the progressive failure of a unidirectional SCS-6/TIMETAL 21S metal matrix composite tensile dogbone specimen at 650 degC. Multiscale progressive failure analyses were performed to quantify the effect of spatially varying fiber strengths on the RUC-averaged and global stress-strain responses and failure. The ultimate composite strengths and distribution of failure locations (predominately within the gage section) reasonably matched the experimentally observed failure behavior. The predicted composite failure behavior suggests that use of macroscale models that exploit global geometric symmetries are inappropriate for cases where the actual distribution of local fiber strengths displays no such symmetries. This issue has not received much attention in the literature. Moreover, the model discretization at a specific length scale can have a profound effect on the computational costs associated with multiscale simulations.models that yield accurate yet tractable results.

  11. A quark model calculation of yy->pipi including final-state interactions

    CERN Document Server

    Blundell, H G; Hay, G; Swanso, E

    2000-01-01

    A quark model calculation of the processes yy->pi+pi- and yy->pipi is performed. At tree level, only charged pions couple to the initial state photons and neutral pions are not exceeded in the final state. However a small but significant cross section is observed. We demonstrate that this may be accounted for by a rotation in isospin space induced by final-state interactions.

  12. Paint Pavement Marking Performance Prediction Model That Includes the Impacts of Snow Removal Operations

    Science.gov (United States)

    2011-03-01

    Hypothesized that snow plows wear down mountain road pavement markings. 2007 Craig et al. -Edge lines degrade slower than center/skip lines 2007...retroreflectivity to create the models. They discovered that paint pavement markings last 80% longer on Portland Cement Concrete than Asphalt Concrete at low AADT...retroreflectivity, while yellow markings lost 21%. Lu and Barter attributed the sizable degradation to snow removal, sand application, and studded

  13. Molten pool-lower head integrity. Heat transfer models including advanced numerical simulations (DNS)

    Energy Technology Data Exchange (ETDEWEB)

    Seiler, J.M.; Bonnet, J.M.; Bernaz, L. [CEA Grenoble (France)

    2001-07-01

    Extensive studies have been performed to investigate the heat transfer within a molten corium pool (homogeneous, stratified and with miscibility gap): Synthesis of heat transfer correlations in molten pool (homogeneous and stratified), Focusing effect in stratified metal layer, DNS analysis of Rayleigh Benard instabilities at the top boundary; interpretation of the different convection regimes and exponents affecting the Rayleigh number in the heat transfer correlations, Molten pool model for corium presenting a miscibility gap. Condition for de-stratification. (authors)

  14. Modeling the Corona and Solar Wind using ADAPT Maps that Include Far-Side Observations

    Science.gov (United States)

    2013-11-01

    document for any purpose other than Government procurement does not in any way obligate the U.S. Government. The fact that the Government formulated...Government’s approval or disapproval of its ideas or findings. Approved for public release; distribution is unlimited. REPORT DOCUMENTATION PAGE...Los Alamos National Laboratory ( LANL ) and the National Solar Observatory (NSO), has developed a model that produces more realistic estimates of the

  15. Numerical modelling of the transport of trace gases including methane in the subsurface of Mars

    Science.gov (United States)

    Stevens, Adam H.; Patel, Manish R.; Lewis, Stephen R.

    2015-04-01

    We model the transport of gas through the martian subsurface in order to quantify the timescales of release of a trace gas with a source at depth using a Fickian model of diffusion through a putative martian regolith column. The model is then applied to the case of methane to determine if diffusive transport of gas can explain previous observations of methane in the martian atmosphere. We investigate which parameters in the model have the greatest effect on transport timescales and show that the calculated diffusivity is very sensitive to the pressure profile of the subsurface, but relatively insensitive to the temperature profile, though diffusive transport may be affected by other temperature dependent properties of the subsurface such as the local vapour pressure. Uncertainties in the structure and physical conditions of the martian subsurface also introduce uncertainties in the timescales calculated. It was found that methane may take several hundred thousand Mars-years to diffuse from a source at depth. Purely diffusive transport cannot explain transient release that varies on timescales of less than one martian year from sources such as serpentinization or methanogenic organisms at depths of more than 2 km. However, diffusion of gas released by the destabilisation of methane clathrate hydrates close to the surface, for example caused by transient mass wasting events or erosion, could produce a rapidly varying flux of methane into the atmosphere of more than 10-3 kg m-2 s-1 over a duration of less than half a martian year, consistent with observations of martian methane variability. Seismic events, magmatic intrusions or impacts could also potentially produce similar patterns of release, but are far more complex to simulate.

  16. Numerical modeling of shallow flows including bottom topography and friction effects

    OpenAIRE

    Lukácová-Medvid'ová, Maria

    2004-01-01

    The aim of the paper is numerical modeling of the shallow water equation with source terms by genuinely multdimensional finite volume evolution Galerkin schemes. The shallow water system, or its one-dimensional analogy the Saint-Venant equation, is used extensively for numerical simulation of natural rivers. Mathematically the shallow water system belongs to the class of balance laws. A special treatment of the source terms describing the bottom topography as well as frictions effects is nece...

  17. A numerical model of the ionosphere, including the E-region above EISCAT

    Directory of Open Access Journals (Sweden)

    P.-Y. Diloy

    Full Text Available It has been previously demonstrated that a two-ion (O+ and H+ 8-moment time-dependent fluid model was able to reproduce correctly the ionospheric structure in the altitude range probed by the EISCAT-VHF radar. In the present study, the model is extended down to the E-region where molecular ion chemistry (NO+ and O+2, essentially prevails over transport; EISCAT-UHF observations confirmed previous theoretical predictions that during events of intense E×B induced convection drifts, molecular ions (mainly NO+ predominate over O+ ions up to altitudes of 300 km. In addition to this extension of the model down to the E-region, the ionization and heating resulting from both solar insolation and particle precipitation is now taken into account in a consistent manner through a complete kinetic transport code. The effects of E×B induced convection drifts on the E- and F-region are presented: the balance between O+ and NO+ ions is drastically affected; the electric field acts to deplete the O+ ion concentration. The [NO+]/[O+] transition altitude varies from 190 km to 320 km as the perpendicular electric field increases from 0 to 100 mV m-1. An interesting additional by-product of the model is that it also predicts the presence of a noticeable fraction of N+ ions in the topside ionosphere in good agreement with Retarding Ion Mass Spectrometer measurements onboard Dynamic Explorer.

  18. Climate change impact modelling needs to include cross-sectoral interactions

    Science.gov (United States)

    Harrison, Paula A.; Dunford, Robert W.; Holman, Ian P.; Rounsevell, Mark D. A.

    2016-09-01

    Climate change impact assessments often apply models of individual sectors such as agriculture, forestry and water use without considering interactions between these sectors. This is likely to lead to misrepresentation of impacts, and consequently to poor decisions about climate adaptation. However, no published research assesses the differences between impacts simulated by single-sector and integrated models. Here we compare 14 indicators derived from a set of impact models run within single-sector and integrated frameworks across a range of climate and socio-economic scenarios in Europe. We show that single-sector studies misrepresent the spatial pattern, direction and magnitude of most impacts because they omit the complex interdependencies within human and environmental systems. The discrepancies are particularly pronounced for indicators such as food production and water exploitation, which are highly influenced by other sectors through changes in demand, land suitability and resource competition. Furthermore, the discrepancies are greater under different socio-economic scenarios than different climate scenarios, and at the sub-regional rather than Europe-wide scale.

  19. Kinetic model of water disinfection using peracetic acid including synergistic effects.

    Science.gov (United States)

    Flores, Marina J; Brandi, Rodolfo J; Cassano, Alberto E; Labas, Marisol D

    2016-01-01

    The disinfection efficiencies of a commercial mixture of peracetic acid against Escherichia coli were studied in laboratory scale experiments. The joint and separate action of two disinfectant agents, hydrogen peroxide and peracetic acid, were evaluated in order to observe synergistic effects. A kinetic model for each component of the mixture and for the commercial mixture was proposed. Through simple mathematical equations, the model describes different stages of attack by disinfectants during the inactivation process. Based on the experiments and the kinetic parameters obtained, it could be established that the efficiency of hydrogen peroxide was much lower than that of peracetic acid alone. However, the contribution of hydrogen peroxide was very important in the commercial mixture. It should be noted that this improvement occurred only after peracetic acid had initiated the attack on the cell. This synergistic effect was successfully explained by the proposed scheme and was verified by experimental results. Besides providing a clearer mechanistic understanding of water disinfection, such models may improve our ability to design reactors.

  20. Including A-Priori Assessment of Actual Evapotranspiration for Green Roof Daily Scale Hydrological Modelling

    Directory of Open Access Journals (Sweden)

    Mirka Mobilia

    2017-01-01

    Full Text Available In the last decades, there has been a widespread implementation of Green Infrastructures worldwide. Among these, green roofs appear to be particularly flexible sustainable drainage facilities. To predict their effectiveness for planning purposes, a tool is required that provides information as a function of local meteorological variables. Thus, a relatively simple daily scale, one-dimensional water balance approach has been proposed. The crucial evapotranspiration process, usually considered as a water balance dependent variable, is replaced here by empirical relationships providing an a-priori assessment of soil water losses through actual evapotranspiration. The modelling scheme, which under some simplification can be used without a calibration process, has been applied to experimental runoff data monitored at a green roof located near Bernkastel (Germany, between April 2005 and December 2006. Two different empirical relationships have been used to model actual evapotranspiration, considering a water availability limited and an energy limited scheme. Model errors quantification, ranging from 2% to 40% on the long-term scale and from 1% to 36% at the event scale, appear strongly related to the particularly considered relationship.

  1. Modelling topical photodynamic therapy treatment including the continuous production of Protoporphyrin IX

    Science.gov (United States)

    Campbell, C. L.; Brown, C. T. A.; Wood, K.; Moseley, H.

    2016-11-01

    Most existing theoretical models of photodynamic therapy (PDT) assume a uniform initial distribution of the photosensitive molecule, Protoporphyrin IX (PpIX). This is an adequate assumption when the prodrug is systematically administered; however for topical PDT this is no longer a valid assumption. Topical application and subsequent diffusion of the prodrug results in an inhomogeneous distribution of PpIX, especially after short incubation times, prior to light illumination. In this work a theoretical simulation of PDT where the PpIX distribution depends on the incubation time and the treatment modality is described. Three steps of the PpIX production are considered. The first is the distribution of the topically applied prodrug, the second in the conversion from the prodrug to PpIX and the third is the light distribution which affects the PpIX distribution through photobleaching. The light distribution is modelled using a Monte Carlo radiation transfer model and indicates treatment depths of around 2 mm during daylight PDT and approximately 3 mm during conventional PDT. The results suggest that treatment depths are not only limited by the light penetration but also by the PpIX distribution.

  2. A stepped leader model for lightning including charge distribution in branched channels

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Wei; Zhang, Li [School of Electrical Engineering, Shandong University, Jinan 250061 (China); Li, Qingmin, E-mail: lqmeee@ncepu.edu.cn [Beijing Key Lab of HV and EMC, North China Electric Power University, Beijing 102206 (China); State Key Lab of Alternate Electrical Power System with Renewable Energy Sources, Beijing 102206 (China)

    2014-09-14

    The stepped leader process in negative cloud-to-ground lightning plays a vital role in lightning protection analysis. As lightning discharge usually presents significant branched or tortuous channels, the charge distribution along the branched channels and the stochastic feature of stepped leader propagation were investigated in this paper. The charge density along the leader channel and the charge in the leader tip for each lightning branch were approximated by introducing branch correlation coefficients. In combination with geometric characteristics of natural lightning discharge, a stochastic stepped leader propagation model was presented based on the fractal theory. By comparing simulation results with the statistics of natural lightning discharges, it was found that the fractal dimension of lightning trajectory in simulation was in the range of that observed in nature and the calculation results of electric field at ground level were in good agreement with the measurements of a negative flash, which shows the validity of this proposed model. Furthermore, a new equation to estimate the lightning striking distance to flat ground was suggested based on the present model. The striking distance obtained by this new equation is smaller than the value estimated by previous equations, which indicates that the traditional equations may somewhat overestimate the attractive effect of the ground.

  3. Numerical Modeling of the Surface Fatigue Crack Propagation Including the Closure Effect

    Science.gov (United States)

    Guchinsky, Ruslan; Petinov, Sergei

    2016-01-01

    Presently modeling of surface fatigue crack growth for residual life assessment of structural elements is almost entirely based on application of the Linear Elastic Fracture Mechanics (LEFM). Generally, it is assumed that the crack front does not essentially change its shape, although it is not always confirmed by experiment. Furthermore, LEFM approach cannot be applied when the stress singularity vanishes due to material plasticity, one of the leading factors associated with the material degradation and fracture. Also, evaluation of stress intensity factors meets difficulties associated with changes in the stress state along the crack front circumference. An approach proposed for simulation the evolution of surface cracks based on application of the Strain-life criterion for fatigue failure and of the finite element modeling of damage accumulation. It takes into account the crack closure effect, the nonlinear behavior of damage accumulation and material compliance increasing due to the damage advance. The damage accumulation technique was applied to model the semi-elliptical crack growth from the initial defect in the steel compact specimen. The results of simulation are in good agreement with the published experimental data.

  4. Bifactor model of WISC-IV: Applicability and measurement invariance in low and normal IQ groups.

    Science.gov (United States)

    Gomez, Rapson; Vance, Alasdair; Watson, Shaun

    2017-07-01

    This study examined the applicability and measurement invariance of the bifactor model of the 10 Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) core subtests in groups of children and adolescents (age range from 6 to 16 years) with low (IQ ≤79; N = 229; % male = 75.9) and normal (IQ ≥80; N = 816; % male = 75.0) IQ scores. Results supported this model in both groups, and there was good support for measurement invariance for this model across these groups. For all participants together, the omega hierarchical and explained common variance (ECV) values were high for the general factor and low to negligible for the specific factors. Together, the findings favor the use of the Full Scale IQ (FSIQ) scores of the WISC-IV, but not the subscale index scores. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  5. Large Scale Structure Formation of normal branch in DGP brane world model

    CERN Document Server

    Song, Yong-Seon

    2007-01-01

    In this paper, we study the large scale structure formation of the normal branch in DGP model (Dvail, Gabadadze and Porrati brane world model) by applying the scaling method developed by Sawicki, Song and Hu for solving the coupled perturbed equations of motion of on-brane and off-brane. There is detectable departure of perturbed gravitational potential from LCDM even at the minimal deviation of the effective equation of state w_eff below -1. The modified perturbed gravitational potential weakens the integrated Sachs-Wolfe effect which is strengthened in the self-accelerating branch DGP model. Additionally, we discuss the validity of the scaling solution in the de Sitter limit at late times.

  6. Galactic habitable zone around M and FGK stars with chemical evolution models that include dust

    Science.gov (United States)

    Spitoni, E.; Gioannini, L.; Matteucci, F.

    2017-09-01

    Context. The Galactic habitable zone is defined as the region with a metallicity that is high enough to form planetary systems in which Earth-like planets could be born and might be capable of sustaining life. Life in this zone needs to survive the destructive effects of nearby supernova explosion events. Aims: Galactic chemical evolution models can be useful tools for studying the galactic habitable zones in different systems. Our aim here is to find the Galactic habitable zone using chemical evolution models for the Milky Way disk, adopting the most recent prescriptions for the evolution of dust and for the probability of finding planetary systems around M and FGK stars. Moreover, for the first time, we express these probabilities in terms of the dust-to-gas ratio of the interstellar medium in the solar neighborhood as computed by detailed chemical evolution models. Methods: At a fixed Galactic time and Galactocentric distance, we determined the number of M and FGK stars that host earths (but no gas giant planets) that survived supernova explosions, using the formalism of our Paper I. Results: The probabilities of finding terrestrial planets but not gas giant planets around M stars deviate substantially from the probabilities around FGK stars for supersolar values of [Fe/H]. For both FGK and M stars, the maximum number of stars hosting habitable planets is at 8 kpc from the Galactic Center when destructive effects by supernova explosions are taken into account. Currently, M stars with habitable planets are ≃10 times more frequent than FGK stars. Moreover, we provide a sixth-order polynomial fit (and a linear fit, but that is more approximated) for the relation found with chemical evolution models in the solar neighborhood between the [Fe/H] abundances and the dust-to-gas ratio. Conclusions: The most likely Galactic zone in which to find terrestrial habitable planets around M and FGK stars is the annular 2 kpc wide region that is centered at 8 kpc from the

  7. Comparison of lead isotopes with source apportionment models, including SOM, for air particulates.

    Science.gov (United States)

    Gulson, Brian; Korsch, Michael; Dickson, Bruce; Cohen, David; Mizon, Karen; Davis, J Michael

    2007-08-01

    We have measured high precision lead isotopes in PM(2.5) particulates from a highly-trafficked site (Mascot) and rural site (Richmond) in the Sydney Basin, New South Wales, Australia to compare with isotopic data from total suspended particulates (TSP) from other sites in the Sydney Basin and evaluate relationships with source fingerprints obtained from multi-element PM(2.5) data. The isotopic data for the period 1998 to 2004 show seasonal peaks and troughs that are more pronounced in the rural site for the PM(2.5).samples but are consistent with the TSP. The Self Organising Map (SOM) method has been applied to the multi-element PM(2.5) data to evaluate its use in obtaining fingerprints for comparison with standard statistical procedures (ANSTO model). As seasonal effects are also significant for the multi-element data, the SOM modelling is reported as site and season dependent. At the Mascot site, the ANSTO model exhibits decreasing (206)Pb/(204)Pb ratios with increasing contributions of fingerprints for "secondary smoke" (industry), "soil", "smoke" and "seaspray". Similar patterns were shown by SOM winter fingerprints for both sites. At the rural site, there are large isotopic variations but for the majority of samples these are not associated with increased contributions from the main sources with the ANSTO model. For two winter sampling times, there are increased contributions from "secondary industry", "smoke", "soil" and seaspray with one time having a source or sources of Pb similar to that of Mascot. The only positive relationship between increasing (206)Pb/(204)Pb ratio and source contributions is found at the rural site using the SOM summer fingerprints, both of which show a significant contribution from sulphur. Several of the fingerprints using either model have significant contributions from black carbon (BC) and/or sulphur (S) that probably derive from diesel fuels and industrial sources. Increased contributions from sources with the SOM summer

  8. A robust macroscopic model for normal-shear coupling, asymmetric and anisotropic behaviors of polycrystalline SMAs

    Science.gov (United States)

    Bodaghi, M.; Damanpack, A. R.; Liao, W. H.

    2016-07-01

    The aim of this article is to develop a robust macroscopic bi-axial model to capture self-accommodation, martensitic transformation/orientation/reorientation, normal-shear deformation coupling and asymmetric/anisotropic strain generation in polycrystalline shape memory alloys. By considering the volume fraction of martensite and its preferred direction as scalar and directional internal variables, constitutive relations are derived to describe basic mechanisms of accommodation, transformation and orientation/reorientation of martensite variants. A new definition is introduced for maximum recoverable strain, which allows the model to capture the effects of tension-compression asymmetry and transformation anisotropy. Furthermore, the coupling effects between normal and shear deformation modes are considered by merging inelastic strain components together. By introducing a calibration approach, material and kinetic parameters of the model are recast in terms of common quantities that characterize a uniaxial phase kinetic diagram. The solution algorithm of the model is presented based on an elastic-predictor inelastic-corrector return mapping process. In order to explore and demonstrate capabilities of the proposed model, theoretical predictions are first compared with existing experimental results on uniaxial tension, compression, torsion and combined tension-torsion tests. Afterwards, experimental results of uniaxial tension, compression, pure bending and buckling tests on {{NiTi}} rods and tubes are replicated by implementing a finite element method along with the Newton-Raphson and Riks techniques to trace non-linear equilibrium path. A good qualitative and quantitative correlation is observed between numerical and experimental results, which verifies the accuracy of the model and the solution procedure.

  9. Estimating developmental states of tumors and normal tissues using a linear time-ordered model

    Directory of Open Access Journals (Sweden)

    Xuan Zhenyu

    2011-02-01

    Full Text Available Abstract Background Tumor cells are considered to have an aberrant cell state, and some evidence indicates different development states appearing in the tumorigenesis. Embryonic development and stem cell differentiation are ordered processes in which the sequence of events over time is highly conserved. The "cancer attractor" concept integrates normal developmental processes and tumorigenesis into a high-dimensional "cell state space", and provides a reasonable explanation of the relationship between these two biological processes from theoretical viewpoint. However, it is hard to describe such relationship by using existed experimental data; moreover, the measurement of different development states is also difficult. Results Here, by applying a novel time-ordered linear model based on a co-bisector which represents the joint direction of a series of vectors, we described the trajectories of development process by a line and showed different developmental states of tumor cells from developmental timescale perspective in a cell state space. This model was used to transform time-course developmental expression profiles of human ESCs, normal mouse liver, ovary and lung tissue into "cell developmental state lines". Then these cell state lines were applied to observe the developmental states of different tumors and their corresponding normal samples. Mouse liver and ovarian tumors showed different similarity to early development stage. Similarly, human glioma cells and ovarian tumors became developmentally "younger". Conclusions The time-ordered linear model captured linear projected development trajectories in a cell state space. Meanwhile it also reflected the change tendency of gene expression over time from the developmental timescale perspective, and our finding indicated different development states during tumorigenesis processes in different tissues.

  10. Evaluation of MCF10A as a Reliable Model for Normal Human Mammary Epithelial Cells.

    Directory of Open Access Journals (Sweden)

    Ying Qu

    Full Text Available Breast cancer is the most common cancer in women and a leading cause of cancer-related deaths for women worldwide. Various cell models have been developed to study breast cancer tumorigenesis, metastasis, and drug sensitivity. The MCF10A human mammary epithelial cell line is a widely used in vitro model for studying normal breast cell function and transformation. However, there is limited knowledge about whether MCF10A cells reliably represent normal human mammary cells. MCF10A cells were grown in monolayer, suspension (mammosphere culture, three-dimensional (3D "on-top" Matrigel, 3D "cell-embedded" Matrigel, or mixed Matrigel/collagen I gel. Suspension culture was performed with the MammoCult medium and low-attachment culture plates. Cells grown in 3D culture were fixed and subjected to either immunofluorescence staining or embedding and sectioning followed by immunohistochemistry and immunofluorescence staining. Cells or slides were stained for protein markers commonly used to identify mammary progenitor and epithelial cells. MCF10A cells expressed markers representing luminal, basal, and progenitor phenotypes in two-dimensional (2D culture. When grown in suspension culture, MCF10A cells showed low mammosphere-forming ability. Cells in mammospheres and 3D culture expressed both luminal and basal markers. Surprisingly, the acinar structure formed by MCF10A cells in 3D culture was positive for both basal markers and the milk proteins β-casein and α-lactalbumin. MCF10A cells exhibit a unique differentiated phenotype in 3D culture which may not exist or be rare in normal human breast tissue. Our results raise a question as to whether the commonly used MCF10A cell line is a suitable model for human mammary cell studies.

  11. Analysis of spatial heterogeneity in normal epithelium and preneoplastic alterations in mouse prostate tumor models

    Science.gov (United States)

    Valkonen, Mira; Ruusuvuori, Pekka; Kartasalo, Kimmo; Nykter, Matti; Visakorpi, Tapio; Latonen, Leena

    2017-01-01

    Cancer involves histological changes in tissue, which is of primary importance in pathological diagnosis and research. Automated histological analysis requires ability to computationally separate pathological alterations from normal tissue with all its variables. On the other hand, understanding connections between genetic alterations and histological attributes requires development of enhanced analysis methods suitable also for small sample sizes. Here, we set out to develop computational methods for early detection and distinction of prostate cancer-related pathological alterations. We use analysis of features from HE stained histological images of normal mouse prostate epithelium, distinguishing the descriptors for variability between ventral, lateral, and dorsal lobes. In addition, we use two common prostate cancer models, Hi-Myc and Pten+/− mice, to build a feature-based machine learning model separating the early pathological lesions provoked by these genetic alterations. This work offers a set of computational methods for separation of early neoplastic lesions in the prostates of model mice, and provides proof-of-principle for linking specific tumor genotypes to quantitative histological characteristics. The results obtained show that separation between different spatial locations within the organ, as well as classification between histologies linked to different genetic backgrounds, can be performed with very high specificity and sensitivity. PMID:28317907

  12. Interpretation of metabolic memory phenomenon using a physiological systems model: What drives oxidative stress following glucose normalization?

    Science.gov (United States)

    Voronova, Veronika; Zhudenkov, Kirill; Helmlinger, Gabriel; Peskov, Kirill

    2017-01-01

    Hyperglycemia is generally associated with oxidative stress, which plays a key role in diabetes-related complications. A complex, quantitative relationship has been established between glucose levels and oxidative stress, both in vitro and in vivo. For example, oxidative stress is known to persist after glucose normalization, a phenomenon described as metabolic memory. Also, uncontrolled glucose levels appear to be more detrimental to patients with diabetes (non-constant glucose levels) vs. patients with high, constant glucose levels. The objective of the current study was to delineate the mechanisms underlying such behaviors, using a mechanistic physiological systems modeling approach that captures and integrates essential underlying pathophysiological processes. The proposed model was based on a system of ordinary differential equations. It describes the interplay between reactive oxygen species production potential (ROS), ROS-induced cell alterations, and subsequent adaptation mechanisms. Model parameters were calibrated using different sources of experimental information, including ROS production in cell cultures exposed to various concentration profiles of constant and oscillating glucose levels. The model adequately reproduced the ROS excess generation after glucose normalization. Such behavior appeared to be driven by positive feedback regulations between ROS and ROS-induced cell alterations. The further oxidative stress-related detrimental effect as induced by unstable glucose levels can be explained by inability of cells to adapt to dynamic environment. Cell adaptation to instable high glucose declines during glucose normalization phases, and further glucose increase promotes similar or higher oxidative stress. In contrast, gradual ROS production potential decrease, driven by adaptation, is observed in cells exposed to constant high glucose. PMID:28178319

  13. Lateral dynamic flight stability of a model hoverfly in normal and inclined stroke-plane hovering.

    Science.gov (United States)

    Xu, Na; Sun, Mao

    2014-09-01

    Many insects hover with their wings beating in a horizontal plane ('normal hovering'), while some insects, e.g., hoverflies and dragonflies, hover with inclined stroke-planes. Here, we investigate the lateral dynamic flight stability of a hovering model hoverfly. The aerodynamic derivatives are computed using the method of computational fluid dynamics, and the equations of motion are solved by the techniques of eigenvalue and eigenvector analysis. The following is shown: The flight of the insect is unstable at normal hovering (stroke-plane angle equals 0) and the instability becomes weaker as the stroke-plane angle increases; the flight becomes stable at a relatively large stroke-plane angle (larger than about 24°). As previously shown, the instability at normal hovering is due to a positive roll-moment/side-velocity derivative produced by the 'changing-LEV-axial-velocity' effect. When the stroke-plane angle increases, the wings bend toward the back of the body, and the 'changing-LEV-axial-velocity' effect decreases; in addition, another effect, called the 'changing-relative-velocity' effect (the 'lateral wind', which is due to the side motion of the insect, changes the relative velocity of its wings), becomes increasingly stronger. This causes the roll-moment/side-velocity derivative to first decrease and then become negative, resulting in the above change in stability as a function of the stroke-plane angle.

  14. STOCHASTIC PRICING MODEL FOR THE REAL ESTATE MARKET: FORMATION OF LOG-NORMAL GENERAL POPULATION

    Directory of Open Access Journals (Sweden)

    Oleg V. Rusakov

    2015-01-01

    Full Text Available We construct a stochastic model of real estate pricing. The method of the pricing construction is based on a sequential comparison of the supply prices. We proof that under standard assumptions imposed upon the comparison coefficients there exists an unique non-degenerated limit in distribution and this limit has the lognormal law of distribution. The accordance of empirical distributions of prices to thetheoretically obtained log-normal distribution we verify by numerous statistical data of real estate prices from Saint-Petersburg (Russia. For establishing this accordance we essentially apply the efficient and sensitive test of fit of Kolmogorov-Smirnov. Basing on “The Russian Federal Estimation Standard N2”, we conclude that the most probable price, i.e. mode of distribution, is correctly and uniquely defined under the log-normal approximation. Since the mean value of log-normal distribution exceeds the mode - most probable value, it follows that the prices valued by the mathematical expectation are systematically overstated.

  15. Able but unintelligent: including positively stereotyped black subgroups in the stereotype content model.

    Science.gov (United States)

    Walzer, Amy S; Czopp, Alexander M

    2011-01-01

    The stereotype content model (SCM) posits that warmth and competence are the key components underlying judgments about social groups. Because competence can encompass different components (e.g., intelligence, talent) different group members may be perceived to be competent for different reasons. Therefore, we believe it may be important to specify the type of competence being assessed when examining perceptions of groups that are positively stereotyped (i.e., Black athletes and musical Blacks). Consistent with the SCM, these subgroups were perceived as high in competence-talent but not in competence-intelligence and low in warmth. Both the intelligence and talent frame of competence fit in the SCM's social structural hypothesis.

  16. Microregion model of a contact line including evaporation, kinetics and slip

    Science.gov (United States)

    Anderson, Daniel; Janecek, Vladislav

    2016-11-01

    We consider the evaporation of a liquid on a uniformly heated solid substrate. In the framework of lubrication theory we consider hydrodynamics, heat conduction, phase change, evaporation kinetics, and slip. Our model focuses only on the contact line 'inner' region which allows us to quantify the impact of evaporation on the apparent contact angle and microregion heat transfer. The linearized problem with respect to the substrate overheating is solved analytically. The analytical solutions are compared with full numerical solutions and to predictions of Hocking.

  17. Mathematical modeling of the hypothalamic–pituitary–adrenal gland (HPA) axis, including hippocampal mechanisms

    DEFF Research Database (Denmark)

    Andersen, Morten; Vinther, Frank; Ottesen, Johnny T.

    2013-01-01

    non-negative and bounded, which can be interpreted as a mathematical formulation of homeostasis. No oscillating solutions are present when using physiologically reasonable parameter values. This indicates that the ultradian rhythm originate from different mechanisms.Using physiologically reasonable......This paper presents a mathematical model of the HPA axis. The HPA axis consists of the hypothalamus, the pituitary and the adrenal glands in which the three hormones CRH, ACTH and cortisol interact through receptor dynamics. Furthermore, it has been suggested that receptors in the hippocampus have...

  18. Nuclear monopole charge form factor calculation for relativistic models including center-of-mass corrections

    Energy Technology Data Exchange (ETDEWEB)

    Avancini, S.S.; Marinelli, J.R. [Universidade Federal de Santa Catarina Florianopolis, Depto de Fisica - CFM, Florianopolis (Brazil); Carlson, B.V. [Instituto Tecnologico de Aeronautica, Sao Jose dos Campos (Brazil)

    2013-06-15

    Relativistic models for finite nuclei contain spurious center-of-mass motion in most applications for the nuclear many-body problem, where the nuclear wave function is taken as a single Slater determinant within a space-fixed frame description. We use the Peierls-Yoccoz projection method, previously developed for relativistic approaches together with a reparametrization of the coupling constants that fits binding energies and charge radius and apply our results to calculate elastic electron scattering monopole charge form factors for light nuclei. (orig.)

  19. Double pendulum model for a tennis stroke including a collision process

    Science.gov (United States)

    Youn, Sun-Hyun

    2015-10-01

    By means of adding a collision process between the ball and racket in the double pendulum model, we analyzed the tennis stroke. The ball and the racket system may be accelerated during the collision time; thus, the speed of the rebound ball does not simply depend on the angular velocity of the racket. A higher angular velocity sometimes gives a lower rebound ball speed. We numerically showed that the proper time-lagged racket rotation increased the speed of the rebound ball by 20%. We also showed that the elbow should move in the proper direction in order to add the angular velocity of the racket.

  20. Modeling the elastic behavior of ductile cast iron including anisotropy in the graphite nodules

    DEFF Research Database (Denmark)

    Andriollo, Tito; Thorborg, Jesper; Hattel, Jesper Henri

    2016-01-01

    This paper presents a micro-mechanical approach to model the intrinsic elastic anisotropy of the graphite particles in ductile iron. Contrary to most of the published works in the field, the constitutive behavior is directly derived on the basis of the nodule characteristic internal structure......, composed of graphite platelets arranged into conical sectors. In this way, the large uncertainty traditionally associated with local mechanical measurements of micro-hardness is eliminated. The proposed anisotropic description is validated by simulating the macroscopic ductile iron elastic response...

  1. Condition monitoring with wind turbine SCADA data using Neuro-Fuzzy normal behavior models

    DEFF Research Database (Denmark)

    Schlechtingen, Meik; Santos, Ilmar

    2012-01-01

    in graphical and text format. Within the paper examples of real faults are provided, showing the capabilities of the method proposed. The method can be applied both to existing and new built turbines without the need of any additional hardware installation or manufacturers input.......This paper presents the latest research results of a project that focuses on normal behavior models for condition monitoring of wind turbines and their components, via ordinary Supervisory Control And Data Acquisition (SCADA) data. In this machine learning approach Adaptive Neuro-Fuzzy Interference...

  2. ASYMPTOTIC NORMALITY OF MAXIMUM QUASI-LIKELIHOOD ESTIMATORS IN GENERALIZED LINEAR MODELS WITH FIXED DESIGN

    Institute of Scientific and Technical Information of China (English)

    Qibing GAO; Yaohua WU; Chunhua ZHU; Zhanfeng WANG

    2008-01-01

    In generalized linear models with fixed design, under the assumption ~ →∞ and otherregularity conditions, the asymptotic normality of maximum quasi-likelihood estimator (β)n, which is the root of the quasi-likelihood equation with natural link function ∑n/i=1Xi(yi-μ(X1/iβ))=0, is obtained,where λ/-n denotes the minimum eigenvalue of ∑n/i=1XiX/1/i, Xi are bounded p x q regressors, and yi are q × 1 responses.

  3. Normalized least-squares estimation in time-varying ARCH models

    OpenAIRE

    Fryzlewicz, Piotr; Sapatinas, Theofanis; Subba Rao, Suhasini

    2008-01-01

    We investigate the time-varying ARCH (tvARCH) process. It is shown that it can be used to describe the slow decay of the sample autocorrelations of the squared returns often observed in financial time series, which warrants the further study of parameter estimation methods for the model. ¶ Since the parameters are changing over time, a successful estimator needs to perform well for small samples. We propose a kernel normalized-least-squares (kernel-NLS) estimator which has a closed form...

  4. Heteroscedastic nonlinear regression models based on scale mixtures of skew-normal distributions.

    Science.gov (United States)

    Lachos, Victor H; Bandyopadhyay, Dipankar; Garay, Aldo M

    2011-08-01

    An extension of some standard likelihood based procedures to heteroscedastic nonlinear regression models under scale mixtures of skew-normal (SMSN) distributions is developed. We derive a simple EM-type algorithm for iteratively computing maximum likelihood (ML) estimates and the observed information matrix is derived analytically. Simulation studies demonstrate the robustness of this flexible class against outlying and influential observations, as well as nice asymptotic properties of the proposed EM-type ML estimates. Finally, the methodology is illustrated using an ultrasonic calibration data.

  5. Including Antenna Models in Microwave Imaging for Breast-Cancer Screening

    DEFF Research Database (Denmark)

    Rubæk, Tonny; Meincke, Peter

    2006-01-01

    Microwave imaging is emerging as a tool for screening for breast cancer, but the lack of methods for including the characteristics of the antennas of the imaging systems in the imaging algorithms limits their performance. In this paper, a method for incorporating the full antenna characteristics......, in terms of the transmission-matrix representation, in a frequency-domain imaging algorithm is presented. The algorithm is tested on a simulation of the Physical-Anomaly Tomography (PAT) scanner imaging system developed at the Technical University of Denmark and is shown to have superior performance when...

  6. The evolution of massive stars including mass loss - Presupernova models and explosion

    Science.gov (United States)

    Woosley, S. E.; Langer, Norbert; Weaver, Thomas A.

    1993-01-01

    The evolution of massive stars of 35, 40, 60, and 85 solar masses is followed through all stages of nuclear burning to the point of Fe core collapse. Critical nuclear reaction and mass-loss rates are varied. Efficient mass loss during the Wolf-Rayet (WR) stage is likely to lead to final masses as small as 4 solar masses. For a reasonable parameterization of the mass loss, there may be convergence of all WR stars, both single and in binaries, to a narrow band of small final masses. Our representative model, a 4.25 solar-mass WR presupernova derived from a 60 solar mass star, is followed through a simulated explosion, and its explosive nucleosynthesis and light curve are determined. Its properties are similar to those observed in Type Ib supernovae. The effects of the initial mass and mass loss on the presupernova structure of small mass WR models is also explored. Important properties of the presupernova star and its explosion can only be obtained by following the complete evolution starting on the main sequence.

  7. Model for external influences on cellular signal transduction pathways including cytosolic calcium oscillations

    Energy Technology Data Exchange (ETDEWEB)

    Eichwald, C.; Kaiser, F. [Technical Univ. of Darmstadt (Germany)

    1995-06-01

    Experiments on the effects of extremely-low-frequency (ELF) electric and magnetic fields on cells of the immune system, T-lymphocytes in particular, suggest that the external field interacts with the cell at the level of intracellular signal transduction pathways. These are directly connected with changes in the calcium-signaling processes of the cell. Based on these findings, a theoretical model for receptor-controlled cytosolic calcium oscillations and for external influences on the signal transduction pathway is presented. The authors discuss the possibility that the external field acts on the kinetics of the signal transduction between the activated receptors at the cell membrane and the G-proteins. It is shown that, depending on the specific combination of cell internal biochemical and external physical parameters, entirely different responses of the cell can occur. The authors compare the effects of a coherent (periodic) modulation and of incoherent perturbations (noise). The model and the calculations are based on the theory of self-sustained, nonlinear oscillators. It is argued that these systems form an ideal basis for information-encoding processes in biological systems.

  8. An Improved Heat Budget Estimation Including Bottom Effects for General Ocean Circulation Models

    Science.gov (United States)

    Carder, Kendall; Warrior, Hari; Otis, Daniel; Chen, R. F.

    2001-01-01

    This paper studies the effects of the underwater light field on heat-budget calculations of general ocean circulation models for shallow waters. The presence of a bottom significantly alters the estimated heat budget in shallow waters, which affects the corresponding thermal stratification and hence modifies the circulation. Based on the data collected during the COBOP field experiment near the Bahamas, we have used a one-dimensional turbulence closure model to show the influence of the bottom reflection and absorption on the sea surface temperature field. The water depth has an almost one-to-one correlation with the temperature rise. Effects of varying the bottom albedo by replacing the sea grass bed with a coral sand bottom, also has an appreciable effect on the heat budget of the shallow regions. We believe that the differences in the heat budget for the shallow areas will have an influence on the local circulation processes and especially on the evaporative and long-wave heat losses for these areas. The ultimate effects on humidity and cloudiness of the region are expected to be significant as well.

  9. On the modelling of semi-insulating GaAs including surface tension and bulk stresses

    Energy Technology Data Exchange (ETDEWEB)

    Dreyer, W.; Duderstadt, F.

    2004-07-01

    Necessary heat treatment of single crystal semi-insulating Gallium Arsenide (GaAs), which is deployed in micro- and opto- electronic devices, generate undesirable liquid precipitates in the solid phase. The appearance of precipitates is influenced by surface tension at the liquid/solid interface and deviatoric stresses in the solid. The central quantity for the description of the various aspects of phase transitions is the chemical potential, which can be additively decomposed into a chemical and a mechanical part. In particular the calculation of the mechanical part of the chemical potential is of crucial importance. We determine the chemical potential in the framework of the St. Venant-Kirchhoff law which gives an appropriate stress/strain relation for many solids in the small strain regime. We establish criteria, which allow the correct replacement of the St. Venant-Kirchhoff law by the simpler Hooke law. The main objectives of this study are: (i) We develop a thermo-mechanical model that describes diffusion and interface motion, which both are strongly influenced by surface tension effects and deviatoric stresses. (ii) We give an overview and outlook on problems that can be posed and solved within the framework of the model. (iii) We calculate non-standard phase diagrams, i.e. those that take into account surface tension and non-deviatoric stresses, for GaAs above 786 C, and we compare the results with classical phase diagrams without these phenomena. (orig.)

  10. Grids of stellar models including second harmonic and colours: Solar composition

    CERN Document Server

    Yildiz, Mutlu

    2015-01-01

    Grids of stellar evolution are required in many fields of astronomy/astrophysics, such as planet hosting stars, binaries, clusters, chemically peculiar stars, etc. In this study, a grid of stellar evolution models with updated ingredients and {recently determined solar abundaces} is presented. The solar values for the initial abundances of hydrogen, heavy elements and mixing-length parameter are 0.0172, 0.7024 and 1.98, respectively. The mass step is small enough (0.01 M$_\\odot$) that interpolation for a given star mass is not required. The range of stellar mass is 0.74 to 10.00 M$_\\odot$. We present results in different forms of tables for easy and general application. The second stellar harmonic, required for analysis of apsidal motion of eclipsing binaries, is also listed. We also construct rotating models to determine effect of rotation on stellar structure and derive fitting formula for luminosity, radius and the second stellar harmonic as a function of rotational parameter. We also compute and list colo...

  11. Analysis of the R-symmetric supersymmetric models including quantum corrections

    CERN Document Server

    Kotlarski, Wojciech

    2016-01-01

    We study the Minimal R-symmetric Supersymmetric Standard Model (MRSSM) at the quantum level. The thesis consists of two parts. First one treats about the electroweak sector of the model. Among others, it identifies the parameter region allowed by the electroweak precision observables. Since the MRSSM contains an $SU(2)_L$-triplet with a non-zero vacuum expectation value the emphasis is put on the calculation of the $W$ boson mass. To that end, a full one-loop calculation of $m_W$ augmented with the leading two-loop SM result is presented. The region is then checked against the measurement of the Higgs boson mass. For this, the full one-loop and leading two-loop corrections to the Higgs boson mass in the MRSSM are calculated. Devised benchmark points, consistent with both of these observables, are shown to fulfill also a number of additional experimental constraints like properties of the Higgs boson(s), $b$-physics observables and vacuum stability. Correlating all of these observables allows to put bounds on ...

  12. Description and Application of A Model of Seepage under A Weir Including Mechanical Clogging

    Directory of Open Access Journals (Sweden)

    Sroka Zbigniew

    2014-07-01

    Full Text Available The paper discusses seepage flow under a damming structure (a weir in view of mechanical clogging in a thin layer at the upstream site. It was assumed that in this layer flow may be treated as one-dimensional (perpendicular to the layer, while elsewhere flow was modelled as two-dimensional. The solution in both zones was obtained in the discrete form using the finite element method and the Euler method. The effect of the clogging layer on seepage flow was modelled using the third kind boundary condition. Seepage parameters in the clogging layer were estimated based on laboratory tests conducted by Skolasińska [2006]. Typical problem was taken to provide simulation and indicate how clogging affects the seepage rate and other parameters of the flow. Results showed that clogging at the upstream site has a significant effect on the distribution of seepage velocity and hydraulic gradients. The flow underneath the structure decreases with time, but these changes are relatively slow.

  13. Simulation of the contraction of the ventricles in a human heart model including atria and pericardium.

    Science.gov (United States)

    Fritz, Thomas; Wieners, Christian; Seemann, Gunnar; Steen, Henning; Dössel, Olaf

    2014-06-01

    During the contraction of the ventricles, the ventricles interact with the atria as well as with the pericardium and the surrounding tissue in which the heart is embedded. The atria are stretched, and the atrioventricular plane moves toward the apex. The atrioventricular plane displacement (AVPD) is considered to be a major contributor to the ventricular function, and a reduced AVPD is strongly related to heart failure. At the same time, the epicardium slides almost frictionlessly on the pericardium with permanent contact. Although the interaction between the ventricles, the atria and the pericardium plays an important role for the deformation of the heart, this aspect is usually not considered in computational models. In this work, we present an electromechanical model of the heart, which takes into account the interaction between ventricles, pericardium and atria and allows to reproduce the AVPD. To solve the contact problem of epicardium and pericardium, a contact handling algorithm based on penalty formulation was developed, which ensures frictionless and permanent contact. Two simulations of the ventricular contraction were conducted, one with contact handling of pericardium and heart and one without. In the simulation with contact handling, the atria were stretched during the contraction of the ventricles, while, due to the permanent contact with the pericardium, their volume increased. In contrast to that, in the simulations without pericardium, the atria were also stretched, but the change in the atrial volume was much smaller. Furthermore, the pericardium reduced the radial contraction of the ventricles and at the same time increased the AVPD.

  14. Effect of neurosteroids on a model lipid bilayer including cholesterol: An Atomic Force Microscopy study.

    Science.gov (United States)

    Sacchi, Mattia; Balleza, Daniel; Vena, Giulia; Puia, Giulia; Facci, Paolo; Alessandrini, Andrea

    2015-05-01

    Amphiphilic molecules which have a biological effect on specific membrane proteins, could also affect lipid bilayer properties possibly resulting in a modulation of the overall membrane behavior. In light of this consideration, it is important to study the possible effects of amphiphilic molecule of pharmacological interest on model systems which recapitulate some of the main properties of the biological plasma membranes. In this work we studied the effect of a neurosteroid, Allopregnanolone (3α,5α-tetrahydroprogesterone or Allo), on a model bilayer composed by the ternary lipid mixture DOPC/bSM/chol. We chose ternary mixtures which present, at room temperature, a phase coexistence of liquid ordered (Lo) and liquid disordered (Ld) domains and which reside near to a critical point. We found that Allo, which is able to strongly partition in the lipid bilayer, induces a marked increase in the bilayer area and modifies the relative proportion of the two phases favoring the Ld phase. We also found that the neurosteroid shifts the miscibility temperature to higher values in a way similarly to what happens when the cholesterol concentration is decreased. Interestingly, an isoform of Allo, isoAllopregnanolone (3β,5α-tetrahydroprogesterone or isoAllo), known to inhibit the effects of Allo on GABAA receptors, has an opposite effect on the bilayer properties.

  15. Thermo-mechanical modeling of turbulent heat transfer in gas-solid flows including particle collisions

    Energy Technology Data Exchange (ETDEWEB)

    Mansoori, Zohreh; Saffar-Avval, Majid; Basirat-Tabrizi, Hassan; Ahmadi, Goodarz; Lain, Santiago

    2002-12-01

    A thermo-mechanical turbulence model is developed and used for predicting heat transfer in a gas-solid flow through a vertical pipe with constant wall heat flux. The new four-way interaction model makes use of the thermal k{sub {theta}}-{tau}{sub {theta}} equations, in addition to the hydrodynamic k-{tau} transport, and accounts for the particle-particle and particle-wall collisions through a Eulerian/Lagrangian formulation. The simulation results indicate that the level of thermal turbulence intensity and the heat transfer are strongly affected by the particle collisions. Inter-particle collisions attenuate the thermal turbulence intensity near the wall but somewhat amplify the temperature fluctuations in the pipe core region. The hydrodynamic-to-thermal times-scale ratio and the turbulent Prandtl number in the region near the wall increase due to the inter-particle collisions. The results also show that the use of a constant or the single-phase gas turbulent Prandtl number produces error in the thermal eddy diffusivity and thermal turbulent intensity fields. Simulation results also indicate that the inter-particle contact heat conduction during collision has no significant effect in the range of Reynolds number and particle diameter studied.

  16. The evolution of massive stars including mass loss - Presupernova models and explosion

    Science.gov (United States)

    Woosley, S. E.; Langer, Norbert; Weaver, Thomas A.

    1993-01-01

    The evolution of massive stars of 35, 40, 60, and 85 solar masses is followed through all stages of nuclear burning to the point of Fe core collapse. Critical nuclear reaction and mass-loss rates are varied. Efficient mass loss during the Wolf-Rayet (WR) stage is likely to lead to final masses as small as 4 solar masses. For a reasonable parameterization of the mass loss, there may be convergence of all WR stars, both single and in binaries, to a narrow band of small final masses. Our representative model, a 4.25 solar-mass WR presupernova derived from a 60 solar mass star, is followed through a simulated explosion, and its explosive nucleosynthesis and light curve are determined. Its properties are similar to those observed in Type Ib supernovae. The effects of the initial mass and mass loss on the presupernova structure of small mass WR models is also explored. Important properties of the presupernova star and its explosion can only be obtained by following the complete evolution starting on the main sequence.

  17. Perceptual-center modeling is affected by including acoustic rate-of-change modulations.

    Science.gov (United States)

    Harsin, C A

    1997-02-01

    This study investigated the acoustic correlates of perceptual centers (p-centers) in CV and VC syllables and developed an acoustic p-center model. In Part 1, listeners located syllables' p-centers by a method-of-adjustment procedure. The CV syllables contained the consonants /s/,/r/,/n/,/t/,/d/,/k/, and /g/; the VCs, the consonants /s/,/r/, and /n/. The vowel in all syllables was /a/. The results of this experiment replicated and extended previous findings regarding the effects of phonetic variation on p-centers. In Part 2, a digital signal processing procedure was used to acoustically model p-center perception. Each stimulus was passed through a six-band digital filter, and the outputs were processed to derive low-frequency modulation components. These components were weighted according to a perceived modulation magnitude function and recombined to create six psychoacoustic envelopes containing modulation energies from 3 to 47 Hz. In this analysis, p-centers were found to be highly correlated with the time-weighted function of the rate-of-change in the psychoacoustic envelopes, multiplied by the psychoacoustic envelope magnitude increment. The results were interpreted as suggesting (1) the probable role of low-frequency energy modulations in p-center perception, and (2) the presence of perceptual processes that integrate multiple articulatory events into a single syllabic event.

  18. 76 FR 66660 - Special Conditions: Gulfstream Aerospace LP (GALP) Model G280 Airplane, Operation Without Normal...

    Science.gov (United States)

    2011-10-27

    ... G280 Airplane, Operation Without Normal Electrical Power AGENCY: Federal Aviation Administration (FAA... design feature associated with operation without normal electrical power. The applicable airworthiness... have a novel or unusual design feature associated with operation without normal electrical power....

  19. Normal Tissue Complication Probability Modeling of Radiation-Induced Hypothyroidism After Head-and-Neck Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Bakhshandeh, Mohsen [Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of); Hashemi, Bijan, E-mail: bhashemi@modares.ac.ir [Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of); Mahdavi, Seied Rabi Mehdi [Department of Medical Physics, Faculty of Medical Sciences, Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of); Nikoofar, Alireza; Vasheghani, Maryam [Department of Radiation Oncology, Hafte-Tir Hospital, Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of); Kazemnejad, Anoshirvan [Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of)

    2013-02-01

    Purpose: To determine the dose-response relationship of the thyroid for radiation-induced hypothyroidism in head-and-neck radiation therapy, according to 6 normal tissue complication probability models, and to find the best-fit parameters of the models. Methods and Materials: Sixty-five patients treated with primary or postoperative radiation therapy for various cancers in the head-and-neck region were prospectively evaluated. Patient serum samples (tri-iodothyronine, thyroxine, thyroid-stimulating hormone [TSH], free tri-iodothyronine, and free thyroxine) were measured before and at regular time intervals until 1 year after the completion of radiation therapy. Dose-volume histograms (DVHs) of the patients' thyroid gland were derived from their computed tomography (CT)-based treatment planning data. Hypothyroidism was defined as increased TSH (subclinical hypothyroidism) or increased TSH in combination with decreased free thyroxine and thyroxine (clinical hypothyroidism). Thyroid DVHs were converted to 2 Gy/fraction equivalent doses using the linear-quadratic formula with {alpha}/{beta} = 3 Gy. The evaluated models included the following: Lyman with the DVH reduced to the equivalent uniform dose (EUD), known as LEUD; Logit-EUD; mean dose; relative seriality; individual critical volume; and population critical volume models. The parameters of the models were obtained by fitting the patients' data using a maximum likelihood analysis method. The goodness of fit of the models was determined by the 2-sample Kolmogorov-Smirnov test. Ranking of the models was made according to Akaike's information criterion. Results: Twenty-nine patients (44.6%) experienced hypothyroidism. None of the models was rejected according to the evaluation of the goodness of fit. The mean dose model was ranked as the best model on the basis of its Akaike's information criterion value. The D{sub 50} estimated from the models was approximately 44 Gy. Conclusions: The implemented

  20. The effect of ignoring individual heterogeneity in Weibull log-normal sire frailty models

    DEFF Research Database (Denmark)

    Damgaard, Lars Holm; Korsgaard, Inge Riis; Simonsen, J;

    2006-01-01

    The objective of this study was, by means of simulation, to quantify the effect of ignoring individual heterogeneity in Weibull sire frailty models on parameter estimates and to address the consequences for genetic inferences. Three simulation studies were evaluated, which included 3 levels...... the software Survival Kit for the incomplete sire model. For the incomplete sire model, the Monte Carlo and Survival Kit parameter estimates were similar. This study established that when unobserved individual heterogeneity was ignored, the parameter estimates that included sire effects were biased toward zero...

  1. Experimental cell transplantation therapy in rat myocardial infarction model including nude rat preparation.

    Science.gov (United States)

    Dai, Wangde; Kloner, Robert A

    2010-01-01

    As a novel potential therapeutic strategy for cardiac disease, cell transplantation therapy has been extensively investigated in experimental studies and clinical trials. Although encouraging results have been demonstrated, a number of critical questions still remain to be answered. For example, what kind of stem cell and how many cells should be used; what is the best time for cell transplantation after acute myocardial infarction; which delivery approach is better, intravenous injection or direct intramyocardial injection? Transplantation of cells derived from human tissues into experimental animals may elicit an immune rejection. Immunodeficient nude rats provide a useful myocardial infarction model for cell transplantation therapy studies. We introduce our detailed methods of direct intramyocardial injection of immature heart cells and stem cells into the myocardial infarction region of rats and nude rats. Careful maintenance under aseptic conditions and proper surgical technique are essential to improve the survival of immunodeficient rats after surgery.

  2. Including ethical considerations in models for first-trimester screening for pre-eclampsia

    DEFF Research Database (Denmark)

    Jørgensen, Jennifer Maureen; Hedley, Paula L.; Gjerris, Mickey;

    2014-01-01

    Recent efforts to develop reliable and efficient early pregnancy screening programmes for pre-eclampsia have focused on com-bining clinical, biochemical and biophysical markers. The same model has been used for first-trimester screening for fetal aneuploidies i.e. prenatal diagnosis (PD), which...... is routinely offered to all pregnant women in many developed countries. Some studies suggest combining PD and pre-eclampsia screening, so women can be offered testing for a number of conditions at the same clinical visit. A combination of these tests may be practical in terms of saving time and resources......; however, the combination raises ethical issues. First-trimester PD and pre-eclampsia screening entail qualitative differences which alter the requirements for disclosure, non-directedness and consent with regard to the informed consent process. This article explores the differences related to the ethical...

  3. Memory of the Vernalized State in Plants including the Model Grass Brachypodium distachyon

    Directory of Open Access Journals (Sweden)

    Daniel P Woods

    2014-03-01

    Full Text Available Plant species that have a vernalization requirement exhibit variation in the ability to remember winter—i.e., variation in the stability of the vernalized state. Studies in Arabidopsis have demonstrated that molecular memory involves changes in the chromatin state and expression of the flowering repressor FLOWERING LOCUS C, and have revealed that single-gene differences can have large effects on the stability of the vernalized state. In the perennial Arabidopsis relative Arabis alpina, the lack of memory of winter is critical for its perennial life history. Our studies of flowering behavior in the model grass Brachypodium distachyon reveal extensive variation in the vernalization requirement, and studies of a particular Brachypodium accession that has a qualitative requirement for both cold exposure and inductive daylength reveals that Brachypodium can exhibit a highly stable vernalized state.

  4. The economic production lot size model extended to include more than one production rate

    DEFF Research Database (Denmark)

    Larsen, Christian

    2001-01-01

    btween the demand rate and the production rate which minimizes unit production costs, and should be used in an increasing order. Then, given the production rates, we derive closed-form expressions for all optimal runtimes as well as the minimum average cost. This analysis reveals that it is the size......We study an extension of the economic production lot size model, where more than one production rate can be used during a cycle. Moreover, the production rates, as well as their corresponding runtimes are decision variables. First, we show that all production rates should be choosen in the interval...... of the setup cost that determines the need for being able to use several production rates. Finally, we show how to derive a near-optimal solution of the general problem....

  5. The economic production lot size model extended to include more than one production rate

    DEFF Research Database (Denmark)

    Larsen, Christian

    2005-01-01

    production rates should be chosen in the interval between the demand rate and the production rate which minimizes unit production costs, and should be used in an increasing order. Then, given the production rates, we derive closed-form expressions for all optimal runtimes as well as the minimum average cost......We study an extension of the economic production lot size model, where more than one production rate can be used during a cycle. Moreover, the production rates, as well as their corresponding runtimes are decision variables. We decompose the problem into two subproblems. First, we show that all....... This analysis reveals that it is the size of the setup cost that determines the need for being able to use several production rates. We also show how to derive a near-optimal solution of the general problem....

  6. Modelling of safety barriers including human and organisational factors to improve process safety

    DEFF Research Database (Denmark)

    Markert, Frank; Duijm, Nijs Jan; Thommesen, Jacob

    2013-01-01

    explosion, and the Mont Blanc Tunnel Fire, such an approach may have helped to maintain the integrity of the designed provisions against major deviations resulting in these disasters. In order to make this paradigm operational, safety management and in particular risk assessment tools need to be refined....... A valuable approach is the inclusion of human and organisational factors into the simulation of the reliability of the technical system using event trees and fault trees and the concept of safety barriers. This has been demonstrated e.g. in the former European research project ARAMIS (Accidental Risk...... Assessment Methodology for IndustrieS, see Salvi et al 2006). ARAMIS employs the bow-tie approach to modelling hazardous scenarios, and it suggests the outcome of auditing safety management to be connected to a semi-quantitative assessment of the quality of safety barriers. ARAMIS discriminates a number...

  7. Robust and Adaptive OMR System Including Fuzzy Modeling, Fusion of Musical Rules, and Possible Error Detection

    Directory of Open Access Journals (Sweden)

    Isabelle Bloch

    2007-01-01

    Full Text Available This paper describes a system for optical music recognition (OMR in case of monophonic typeset scores. After clarifying the difficulties specific to this domain, we propose appropriate solutions at both image analysis level and high-level interpretation. Thus, a recognition and segmentation method is designed, that allows dealing with common printing defects and numerous symbol interconnections. Then, musical rules are modeled and integrated, in order to make a consistent decision. This high-level interpretation step relies on the fuzzy sets and possibility framework, since it allows dealing with symbol variability, flexibility, and imprecision of music rules, and merging all these heterogeneous pieces of information. Other innovative features are the indication of potential errors and the possibility of applying learning procedures, in order to gain in robustness. Experiments conducted on a large data base show that the proposed method constitutes an interesting contribution to OMR.

  8. Robust and Adaptive OMR System Including Fuzzy Modeling, Fusion of Musical Rules, and Possible Error Detection

    Science.gov (United States)

    Rossant, Florence; Bloch, Isabelle

    2006-12-01

    This paper describes a system for optical music recognition (OMR) in case of monophonic typeset scores. After clarifying the difficulties specific to this domain, we propose appropriate solutions at both image analysis level and high-level interpretation. Thus, a recognition and segmentation method is designed, that allows dealing with common printing defects and numerous symbol interconnections. Then, musical rules are modeled and integrated, in order to make a consistent decision. This high-level interpretation step relies on the fuzzy sets and possibility framework, since it allows dealing with symbol variability, flexibility, and imprecision of music rules, and merging all these heterogeneous pieces of information. Other innovative features are the indication of potential errors and the possibility of applying learning procedures, in order to gain in robustness. Experiments conducted on a large data base show that the proposed method constitutes an interesting contribution to OMR.

  9. Parsing recursive sentences with a connectionist model including a neural stack and synaptic gating.

    Science.gov (United States)

    Fedor, Anna; Ittzés, Péter; Szathmáry, Eörs

    2011-02-21

    It is supposed that humans are genetically predisposed to be able to recognize sequences of context-free grammars with centre-embedded recursion while other primates are restricted to the recognition of finite state grammars with tail-recursion. Our aim was to construct a minimalist neural network that is able to parse artificial sentences of both grammars in an efficient way without using the biologically unrealistic backpropagation algorithm. The core of this network is a neural stack-like memory where the push and pop operations are regulated by synaptic gating on the connections between the layers of the stack. The network correctly categorizes novel sentences of both grammars after training. We suggest that the introduction of the neural stack memory will turn out to be substantial for any biological 'hierarchical processor' and the minimalist design of the model suggests a quest for similar, realistic neural architectures.

  10. Areal rainfall estimation using moving cars - computer experiments including hydrological modeling

    Science.gov (United States)

    Rabiei, Ehsan; Haberlandt, Uwe; Sester, Monika; Fitzner, Daniel; Wallner, Markus

    2016-09-01

    The need for high temporal and spatial resolution precipitation data for hydrological analyses has been discussed in several studies. Although rain gauges provide valuable information, a very dense rain gauge network is costly. As a result, several new ideas have emerged to help estimating areal rainfall with higher temporal and spatial resolution. Rabiei et al. (2013) observed that moving cars, called RainCars (RCs), can potentially be a new source of data for measuring rain rate. The optical sensors used in that study are designed for operating the windscreen wipers and showed promising results for rainfall measurement purposes. Their measurement accuracy has been quantified in laboratory experiments. Considering explicitly those errors, the main objective of this study is to investigate the benefit of using RCs for estimating areal rainfall. For that, computer experiments are carried out, where radar rainfall is considered as the reference and the other sources of data, i.e., RCs and rain gauges, are extracted from radar data. Comparing the quality of areal rainfall estimation by RCs with rain gauges and reference data helps to investigate the benefit of the RCs. The value of this additional source of data is not only assessed for areal rainfall estimation performance but also for use in hydrological modeling. Considering measurement errors derived from laboratory experiments, the result shows that the RCs provide useful additional information for areal rainfall estimation as well as for hydrological modeling. Moreover, by testing larger uncertainties for RCs, they observed to be useful up to a certain level for areal rainfall estimation and discharge simulation.

  11. ECO: a generic eutrophication model including comprehensive sediment-water interaction.

    Directory of Open Access Journals (Sweden)

    Johannes G C Smits

    Full Text Available The content and calibration of the comprehensive generic 3D eutrophication model ECO for water and sediment quality is presented. Based on a computational grid for water and sediment, ECO is used as a tool for water quality management to simulate concentrations and mass fluxes of nutrients (N, P, Si, phytoplankton species, detrital organic matter, electron acceptors and related substances. ECO combines integral simulation of water and sediment quality with sediment diagenesis and closed mass balances. Its advanced process formulations for substances in the water column and the bed sediment were developed to allow for a much more dynamic calculation of the sediment-water exchange fluxes of nutrients as resulting from steep concentration gradients across the sediment-water interface than is possible with other eutrophication models. ECO is to more accurately calculate the accumulation of organic matter and nutrients in the sediment, and to allow for more accurate prediction of phytoplankton biomass and water quality in response to mitigative measures such as nutrient load reduction. ECO was calibrated for shallow Lake Veluwe (The Netherlands. Due to restoration measures this lake underwent a transition from hypertrophic conditions to moderately eutrophic conditions, leading to the extensive colonization by submerged macrophytes. ECO reproduces observed water quality well for the transition period of ten years. The values of its process coefficients are in line with ranges derived from literature. ECO's calculation results underline the importance of redox processes and phosphate speciation for the nutrient return fluxes. Among other things, the results suggest that authigenic formation of a stable apatite-like mineral in the sediment can contribute significantly to oligotrophication of a lake after a phosphorus load reduction.

  12. Parameterization of cloud droplet formation for global and regional models: including adsorption activation from insoluble CCN

    Directory of Open Access Journals (Sweden)

    P. Kumar

    2009-04-01

    Full Text Available Dust and black carbon aerosol have long been known to exert potentially important and diverse impacts on cloud droplet formation. Most studies to date focus on the soluble fraction of these particles, and overlook interactions of the insoluble fraction with water vapor (even if known to be hydrophilic. To address this gap, we developed a new parameterization that considers cloud droplet formation within an ascending air parcel containing insoluble (but wettable particles externally mixed with aerosol containing an appreciable soluble fraction. Activation of particles with a soluble fraction is described through well-established Köhler theory, while the activation of hydrophilic insoluble particles is treated by "adsorption-activation" theory. In the latter, water vapor is adsorbed onto insoluble particles, the activity of which is described by a multilayer Frenkel-Halsey-Hill (FHH adsorption isotherm modified to account for particle curvature. We further develop FHH activation theory to i find combinations of the adsorption parameters AFHH, BFHH which yield atmospherically-relevant behavior, and, ii express activation properties (critical supersaturation that follow a simple power law with respect to dry particle diameter.

    The new parameterization is tested by comparing the parameterized cloud droplet number concentration against predictions with a detailed numerical cloud model, considering a wide range of particle populations, cloud updraft conditions, water vapor condensation coefficient and FHH adsorption isotherm characteristics. The agreement between parameterization and parcel model is excellent, with an average error of 10% and R2~0.98. A preliminary sensitivity study suggests that the sublinear response of droplet number to Köhler particle concentration is not as strong for FHH particles.

  13. Parameterization of cloud droplet formation for global and regional models: including adsorption activation from insoluble CCN

    Science.gov (United States)

    Kumar, P.; Sokolik, I. N.; Nenes, A.

    2009-04-01

    Dust and black carbon aerosol have long been known to exert potentially important and diverse impacts on cloud droplet formation. Most studies to date focus on the soluble fraction of these particles, and overlook interactions of the insoluble fraction with water vapor (even if known to be hydrophilic). To address this gap, we developed a new parameterization that considers cloud droplet formation within an ascending air parcel containing insoluble (but wettable) particles externally mixed with aerosol containing an appreciable soluble fraction. Activation of particles with a soluble fraction is described through well-established Köhler theory, while the activation of hydrophilic insoluble particles is treated by "adsorption-activation" theory. In the latter, water vapor is adsorbed onto insoluble particles, the activity of which is described by a multilayer Frenkel-Halsey-Hill (FHH) adsorption isotherm modified to account for particle curvature. We further develop FHH activation theory to i) find combinations of the adsorption parameters AFHH, BFHH which yield atmospherically-relevant behavior, and, ii) express activation properties (critical supersaturation) that follow a simple power law with respect to dry particle diameter. The new parameterization is tested by comparing the parameterized cloud droplet number concentration against predictions with a detailed numerical cloud model, considering a wide range of particle populations, cloud updraft conditions, water vapor condensation coefficient and FHH adsorption isotherm characteristics. The agreement between parameterization and parcel model is excellent, with an average error of 10% and R2~0.98. A preliminary sensitivity study suggests that the sublinear response of droplet number to Köhler particle concentration is not as strong for FHH particles.

  14. ECO: a generic eutrophication model including comprehensive sediment-water interaction.

    Science.gov (United States)

    Smits, Johannes G C; van Beek, Jan K L

    2013-01-01

    The content and calibration of the comprehensive generic 3D eutrophication model ECO for water and sediment quality is presented. Based on a computational grid for water and sediment, ECO is used as a tool for water quality management to simulate concentrations and mass fluxes of nutrients (N, P, Si), phytoplankton species, detrital organic matter, electron acceptors and related substances. ECO combines integral simulation of water and sediment quality with sediment diagenesis and closed mass balances. Its advanced process formulations for substances in the water column and the bed sediment were developed to allow for a much more dynamic calculation of the sediment-water exchange fluxes of nutrients as resulting from steep concentration gradients across the sediment-water interface than is possible with other eutrophication models. ECO is to more accurately calculate the accumulation of organic matter and nutrients in the sediment, and to allow for more accurate prediction of phytoplankton biomass and water quality in response to mitigative measures such as nutrient load reduction. ECO was calibrated for shallow Lake Veluwe (The Netherlands). Due to restoration measures this lake underwent a transition from hypertrophic conditions to moderately eutrophic conditions, leading to the extensive colonization by submerged macrophytes. ECO reproduces observed water quality well for the transition period of ten years. The values of its process coefficients are in line with ranges derived from literature. ECO's calculation results underline the importance of redox processes and phosphate speciation for the nutrient return fluxes. Among other things, the results suggest that authigenic formation of a stable apatite-like mineral in the sediment can contribute significantly to oligotrophication of a lake after a phosphorus load reduction.

  15. Field theory of bicritical and tetracritical points. III. Relaxational dynamics including conservation of magnetization (model C).

    Science.gov (United States)

    Folk, R; Holovatch, Yu; Moser, G

    2009-03-01

    We calculate the relaxational dynamical critical behavior of systems of O(n_{ parallel}) plus sign in circleO(n_{ perpendicular}) symmetry including conservation of magnetization by renormalization group theory within the minimal subtraction scheme in two-loop order. Within the stability region of the Heisenberg fixed point and the biconical fixed point, strong dynamical scaling holds, with the asymptotic dynamical critical exponent z=2varphinu-1 , where varphi is the crossover exponent and nu the exponent of the correlation length. The critical dynamics at n_{ parallel}=1 and n_{ perpendicular}=2 is governed by a small dynamical transient exponent leading to nonuniversal nonasymptotic dynamical behavior. This may be seen, e.g., in the temperature dependence of the magnetic transport coefficients.

  16. Combined soft and skeletal tissue modelling of normal and dysmorphic midface postnatal development.

    Science.gov (United States)

    Ibrahim, Amel; Suttie, Michael; Bulstrode, Neil W; Britto, Jonathan A; Dunaway, David; Hammond, Peter; Ferretti, Patrizia

    2016-11-01

    Midface hypoplasia as exemplified by Treacher Collins Syndrome (TCS) can impair appearance and function. Reconstruction involves multiple invasive surgeries with variable long-term outcomes. This study aims to describe normal and dysmorphic midface postnatal development through combined modelling of skeletal and soft tissues and to develop a surgical evaluation tool. Midface skeletal and soft tissue surfaces were extracted from computed tomography scans of 52 control and 14 TCS children, then analysed using dense surface modelling. The model was used to describe midface growth, morphology, and asymmetry, then evaluate postoperative outcomes. Parameters responsible for the greatest variation in midface size and shape showed differences between TCS and controls with close alignment between skeletal and soft tissue models. TCS children exhibited midface dysmorphology and hypoplasia when compared with controls. Asymmetry was also significantly higher in TCS midfaces. Combined modelling was used to evaluate the impact of surgery in one TCS individual who showed normalisation immediately after surgery but reversion towards TCS dysmorphology after 1 year. This is the first quantitative analysis of postnatal midface development using combined modelling of skeletal and soft tissues. We also provide an approach for evaluation of surgical outcomes, laying the foundations for future development of a preoperative planning tool. Copyright © 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  17. Anatomically realistic multiscale models of normal and abnormal gastrointestinal electrical activity.

    Science.gov (United States)

    Cheng, Leo K; Komuro, Rie; Austin, Travis M; Buist, Martin L; Pullan, Andrew J

    2007-03-01

    One of the major aims of the International Union of Physiological Sciences (IUPS) Physiome Project is to develop multiscale mathematical and computer models that can be used to help understand human health. We present here a small facet of this broad plan that applies to the gastrointestinal system. Specifically, we present an anatomically and physiologically based modelling framework that is capable of simulating normal and pathological electrical activity within the stomach and small intestine. The continuum models used within this framework have been created using anatomical information derived from common medical imaging modalities and data from the Visible Human Project. These models explicitly incorporate the various smooth muscle layers and networks of interstitial cells of Cajal (ICC) that are known to exist within the walls of the stomach and small bowel. Electrical activity within individual ICCs and smooth muscle cells is simulated using a previously published simplified representation of the cell level electrical activity. This simulated cell level activity is incorporated into a bidomain representation of the tissue, allowing electrical activity of the entire stomach or intestine to be simulated in the anatomically derived models. This electrical modelling framework successfully replicates many of the qualitative features of the slow wave activity within the stomach and intestine and has also been used to investigate activity associated with functional uncoupling of the stomach.

  18. Anatomically realistic multiscale models of normal and abnormal gastrointestinal electrical activity

    Institute of Scientific and Technical Information of China (English)

    Leo K Cheng; Rie Komuro; Travis M Austin; Martin L Buist; Andrew J Pullan

    2007-01-01

    One of the major aims of the Tnternational Union of Physiological Sciences (IUPS) Physiome Project is to develop multiscale mathematical and computer models that can be used to help understand human health.We present here a small facet of this broad plan that applies to the gastrointestinal system. Specifically,we present an anatomically and physiologically based modelling framework that is capable of simulating normal and pathological electrical activity within the stomach and small intestine. The continuum models used within this framework have been created using anatomical information derived from common medical imaging modalities and data from the Visible Human Project. These models explicitly incorporate the various smooth muscle layers and networks of interstitial cells of Cajal (ICC) that are known to exist within the walls of the stomach and small bowel. Electrical activity within individual ICCs and smooth muscle cells is simulated using a previously published simplified representation of the cell level electrical activity. This simulated cell level activity is incorporated into a bidomain representation of the tissue, allowing electrical activity of the entire stomach or intestine to be simulated in the anatomically derived models. This electrical modelling framework successfully replicates many of the qualitative features of the slow wave activity within the stomach and intestine and has also been used to investigate activity associated with functional uncoupling of the stomach.

  19. Robust estimation of cerebral hemodynamics in neonates using multilayered diffusion model for normal and oblique incidences.

    Science.gov (United States)

    Steinberg, Idan; Harbater, Osnat; Gannot, Israel

    2014-07-01

    The diffusion approximation is useful for many optical diagnostics modalities, such as near-infrared spectroscopy. However, the simple normal incidence, semi-infinite layer model may prove lacking in estimation of deep-tissue optical properties such as required for monitoring cerebral hemodynamics, especially in neonates. To answer this need, we present an analytical multilayered, oblique incidence diffusion model. Initially, the model equations are derived in vector-matrix form to facilitate fast and simple computation. Then, the spatiotemporal reflectance predicted by the model for a complex neonate head is compared with time-resolved Monte Carlo (TRMC) simulations under a wide range of physiologically feasible parameters. The high accuracy of the multilayer model is demonstrated in that the deviation from TRMC simulations is only a few percent even under the toughest conditions. We then turn to solve the inverse problem and estimate the oxygen saturation of deep brain tissues based on the temporal and spatial behaviors of the reflectance. Results indicate that temporal features of the reflectance are more sensitive to deep-layer optical parameters. The accuracy of estimation is shown to be more accurate and robust than the commonly used single-layer diffusion model. Finally, the limitations of such approaches are discussed thoroughly.

  20. Automated Separation of Stars and Normal Galaxies Based on Statistical Mixture Modeling with RBF Neural Net-works

    Institute of Scientific and Technical Information of China (English)

    Dong-Mei Qin; Ping Guo; Zhan-Yi Hu; Yong-Heng Zhao

    2003-01-01

    For LAMOST, the largest sky survey program in China, the solution ofthe problem of automatic discrimination of stars from galaxies by spectra has shownthat the results of the PSF test can be significantly refined. However, the problemis made worse when the redshifts of galaxies are not available. We present a newautomatic method of star/(normal) galaxy separation, which is based on StatisticalMixture Modeling with Radial Basis Function Neural Networks (SMM-RBFNN).This work is a continuation of our previous one, where active and non-active celestialobjects were successfully segregated. By combining the method in this paper andthe previous one, stars can now be effectively separated from galaxies and AGNs bytheir spectra-a major goal of LAMOST, and an indispensable step in any automaticspectrum classification system. In our work, the training set includes standardstellar spectra from Jacoby's spectrum library and simulated galaxy spectra of E0,SO, Sa, Sb types with redshift ranging from 0 to 1.2, and the test set of stellarspectra from Pickles' atlas and SDSS spectra of normal galaxies with SNR of 13.Experiments show that our SMM-RBFNN is more efficient in both the trainingand testing stages than the BPNN (back propagation neural networks), and moreimportantly, it can achieve a good classification accuracy of 99.22% and 96.52%,respectively for stars and normal galaxies.

  1. Regional modelling of future African climate north of 15S including greenhouse warming and land degradation

    Energy Technology Data Exchange (ETDEWEB)

    Paeth, H. [Geographical Institute, University of Wuerzburg, Am Hubland, 97074 Wuerzburg (Germany); Thamm, H.P. [Geographical Institute, University of Bonn, Bonn (Germany)

    2007-08-15

    Previous studies have highlighted the crucial role of land degradation in tropical African climate. This effect urgently has to be taken into account when predicting future African climate under enhanced greenhouse conditions. Here, we present time slice experiments of African climate until 2025, using a high-resolution regional climate model. A supposable scenario of future land use changes, involving vegetation loss and soil degradation, is prescribed simultaneously with increasing greenhouse-gas concentrations in order to detect, where the different forcings counterbalance or reinforce each other. This proceeding allows us to define the regions of highest vulnerability with respect to future freshwater availability and food security in tropical and subtropical Africa and may provide a decision basis for political measures. The model simulates a considerable reduction in precipitation amount until 2025 over most of tropical Africa, amounting to partly more than 500 mm (20-40% of the annual sum), particularly in the Congo Basin and the Sahel Zone. The change is strongest in boreal summer and basically reflects the pattern of maximum vegetation cover during the seasonal cycle. The related change in the surface energy fluxes induces a substantial near-surface warming by up to 7C. According to the modified temperature gradients over tropical Africa, the summer monsoon circulation intensifies and transports more humid air masses into the southern part of West Africa. This humidifying effect is overcompensated by a remarkable decrease in surface evaporation, leading to the overall drying tendency over most of Africa. Extreme daily rainfall events become stronger in autumn but less intense in spring. Summer and autumn appear to be characterized by more severe heat waves over Subsaharan West Africa. In addition, the Tropical Easterly Jet is weakening, leading to enhanced drought conditions in the Sahel Zone. All these results suggest that the local impact of land

  2. Nuclear Reactor/Hydrogen Process Interface Including the HyPEP Model

    Energy Technology Data Exchange (ETDEWEB)

    Steven R. Sherman

    2007-05-01

    The Nuclear Reactor/Hydrogen Plant interface is the intermediate heat transport loop that will connect a very high temperature gas-cooled nuclear reactor (VHTR) to a thermochemical, high-temperature electrolysis, or hybrid hydrogen production plant. A prototype plant called the Next Generation Nuclear Plant (NGNP) is planned for construction and operation at the Idaho National Laboratory in the 2018-2021 timeframe, and will involve a VHTR, a high-temperature interface, and a hydrogen production plant. The interface is responsible for transporting high-temperature thermal energy from the nuclear reactor to the hydrogen production plant while protecting the nuclear plant from operational disturbances at the hydrogen plant. Development of the interface is occurring under the DOE Nuclear Hydrogen Initiative (NHI) and involves the study, design, and development of high-temperature heat exchangers, heat transport systems, materials, safety, and integrated system models. Research and development work on the system interface began in 2004 and is expected to continue at least until the start of construction of an engineering-scale demonstration plant.

  3. A fully model-based MPC solution including VSB shot dose assignment and shape correction

    Science.gov (United States)

    Bork, Ingo; Buck, Peter; Reddy, Murali; Durvasula, Bhardwaj

    2015-10-01

    The value of using multiple dose levels for individual shots on VSB (Variable Shaped Beam) mask writers has been demonstrated earlier [1][2]. The main advantage of modulating dose on a per shot basis is the fact that higher dose levels can be used selectively for critical features while other areas of the mask with non-critical feature types can be exposed at lower dose levels. This reduces the amount of backscattering and mask write time penalty compared to a global overdose-undersize approach. While dose assignment to certain polygons or parts of polygons (VSB shots) can easily be accomplished via DRC rules on layers with limited shape variations like contact or VIA layers, it can be challenging to come up with consistent rules for layers consisting of a very broad range of shapes, generally found on metal layers. This work introduces a method for fully model-based modulation of shot dose for VSB machines supporting between two and eight dose levels and demonstrates results achieved with this method.

  4. Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model

    Science.gov (United States)

    Pilgrim, Matthew G.; Lengyel, Imre; Lanzirotti, Antonio; Newville, Matt; Fearn, Sarah; Emri, Eszter; Knowles, Jonathan C.; Messinger, Jeffrey D.; Read, Russell W.; Guidry, Clyde; Curcio, Christine A.

    2017-01-01

    Purpose Extracellular deposits containing hydroxyapatite, lipids, proteins, and trace metals that form between the basal lamina of the RPE and the inner collagenous layer of Bruch's membrane are hallmarks of early AMD. We examined whether cultured RPE cells could produce extracellular deposits containing all of these molecular components. Methods Retinal pigment epithelium cells isolated from freshly enucleated porcine eyes were cultured on Transwell membranes for up to 6 months. Deposit composition and structure were characterized using light, fluorescence, and electron microscopy; synchrotron x-ray diffraction and x-ray fluorescence; secondary ion mass spectroscopy; and immunohistochemistry. Results Apparently functional primary RPE cells, when cultured on 10-μm-thick inserts with 0.4-μm-diameter pores, can produce sub-RPE deposits that contain hydroxyapatite, lipids, proteins, and trace elements, without outer segment supplementation, by 12 weeks. Conclusions The data suggest that sub-RPE deposit formation is initiated, and probably regulated, by the RPE, as well as the loss of permeability of the Bruch's membrane and choriocapillaris complex associated with age and early AMD. This cell culture model of early AMD lesions provides a novel system for testing new therapeutic interventions against sub-RPE deposit formation, an event occurring well in advance of the onset of vision loss. PMID:28146236

  5. Going beyond efficiency: including altruistic motives in behavioral models for sustainability transitions to address sufficiency

    Directory of Open Access Journals (Sweden)

    Niko Schäpke

    2014-07-01

    Full Text Available Sustainability transitions require altered individual behaviors. Policies aimed at changing people’s consumption behavior are designed according to efficiency, consistency, and sufficiency principles. Taking into account shortcomings of the first two principles, this paper specifically addresses the sufficiency principle. Sufficiency policies are not very popular due to the fear that they may impede quality of life. This fear might be eased when highlighting the motivational side of sustainable behavior, such as the wish to care for future generations and the world’s poor. This article uses the capability approach (CA, developed primarily by Nobel-laureate economist Amartya Sen (1987a and philosopher Martha Nussbaum (1993, 2000, to a include the differentiation between self- and other-oriented goals and behavior, b build on its demonstrated success in assessing quality of life, and c assess the sustainability of behavior and policies. These three facets make CA suitable to analyze the effectiveness of sufficiency policies on sustainability and quality of life. To better understand the motivational side of sustainable behavior, CA is here for the first time enriched through approaches from environmental psychology. This enables us to highlight the idea of intrinsic empowerment as a building block for sufficiency policies. We close the article by highlighting further avenues for research.

  6. NORMALIZED DIFFERENCE SNOW INDEX SIMULATION FOR SNOW-COVER MAPPING IN FOREST BY GEOSAIL MODEL

    Institute of Scientific and Technical Information of China (English)

    CAO Yun-gang; LIU Chuang

    2006-01-01

    The snow-cover mapping in forest area is always one of the difficult points for optical satellite remote sensing. To investigate reflectance variability and to improve the mapping of snow in forest area, GeoSail model was used to simulate the reflectance of a snow-covered forest. Using this model, the effects of varying canopy density, solar illumination and view geometry on the performance of the MODIS (Moderate-resolution Imaging Spectroradiometer)snow-cover mapping algorithm were investigated. The relationship between NDSI (Normalized Difference Snow Index), NDVI (Normalized Difference Vegetation Index) and snow fraction was discussed in detail. Results indicated that the weak performance would be achieved if fixed criteria were used for different regions especially in the complicated land cover components. Finally, some suggestions to MODIS SNOWMAP algorithm were put forward to improve snow mapping precision in forest area based on the simulation, for example, new criteria should be used in coniferous forest, that is, NDSI greater than 0.3 and NDVI greater than zero. Otherwise, a threshold on view zenith angle may be used in the criteria such as 45°.

  7. Current diffusion and normal zone propagation inside the aluminum stabilized superconductor of ATLAS model coil

    CERN Document Server

    Boxman, E W; Pellegatta, M; ten Kate, H H J

    2003-01-01

    The normal zone propagation inside the B/sub O/ model coil of the ATLAS Toroidal magnet has been measured over a large range of applied currents. Typical values for the longitudinal propagation vary from 0.3 to 15 m/s at 8 and 24 kA, respectively. A new analytical expression for the longitudinal quench propagation inside superconducting cables is presented. It describes the propagation inside superconducting wires as well as the propagation inside large stabilized superconductors. It is found that in the limit case of high currents, the stabilizer functions only as a heat-sink. The model is compared to experimental data and a good correlation is found. (10 refs).

  8. A Platoon Dispersion Model Based on a Truncated Normal Distribution of Speed

    Directory of Open Access Journals (Sweden)

    Ming Wei

    2012-01-01

    Full Text Available Understanding platoon dispersion is critical for the coordination of traffic signal control in an urban traffic network. Assuming that platoon speed follows a truncated normal distribution, ranging from minimum speed to maximum speed, this paper develops a piecewise density function that describes platoon dispersion characteristics as the platoon moves from an upstream to a downstream intersection. Based on this density function, the expected number of cars in the platoon that pass the downstream intersection, and the expected number of cars in the platoon that do not pass the downstream point are calculated. To facilitate coordination in a traffic signal control system, dispersion models for the front and the rear of the platoon are also derived. Finally, a numeric computation for the coordination of successive signals is presented to illustrate the validity of the proposed model.

  9. Normalization of ventral tegmental area structure following acupuncture in a rat model of heroin relapse

    Institute of Scientific and Technical Information of China (English)

    Rongjun Zhang; Xinghui Cai; Xiaoge Song; Chaoyang Dong; Xiaorong Hou; Lei Lv

    2014-01-01

    Drugs can cause obvious damage to the brain. To verify the relationship between acupuncture, neurotrophic factor expression and brain cell structural changes, this study established a rat model of heroin relapse using intramuscular injection of increasing amounts of heroin. During the detoxiifcation period, rat models received acupuncture at Baihui (DU20) and Dazhui (DU14). Electron microscopy demonstrated that the structure of the ventral tegmental area in heroin relapse rats gradually became normalized after acupuncture treatment. Immunohistochem-ical staining exhibited that the expression of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor increased in the ventral tegmental area following acupuncture. Moreover, the effects were similar to that of methadone, a type of medicine called an opioid. Results suggested that acupuncture at Baihui and Dazhui protected brain neurons against injury in rats with heroin relapse by promoting brain-derived neurotrophic factor and glial cell line-de-rived neurotrophic factor expression.

  10. Modeling aeolian transport of soil-bound plutonium: considering infrequent but normal environmental disturbances is critical in estimating future dose.

    Science.gov (United States)

    Michelotti, Erika A; Whicker, Jeffrey J; Eisele, William F; Breshears, David D; Kirchner, Thomas B

    2013-06-01

    Dose assessments typically consider environmental systems as static through time, but environmental disturbances such as drought and fire are normal, albeit infrequent, events that can impact dose-influential attributes of many environmental systems. These phenomena occur over time frames of decades or longer, and are likely to be exacerbated under projected warmer, drier climate. As with other types of dose assessment, the impacts of environmental disturbances are often overlooked when evaluating dose from aeolian transport of radionuclides and other contaminants. Especially lacking are predictions that account for potential changing vegetation cover effects on radionuclide transport over the long time frames required by regulations. A recently developed dynamic wind-transport model that included vegetation succession and environmental disturbance provides more realistic long-term predictability. This study utilized the model to estimate emission rates for aeolian transport, and compare atmospheric dispersion and deposition rates of airborne plutonium-contaminated soil into neighboring areas with and without environmental disturbances. Specifically, the objective of this study was to utilize the model results as input for a widely used dose assessment model (CAP-88). Our case study focused on low levels of residual plutonium found in soils from past operations at Los Alamos National Laboratory (LANL), in Los Alamos, NM, located in the semiarid southwestern USA. Calculations were conducted for different disturbance scenarios based on conditions associated with current climate, and a potential future drier and warmer climate. Known soil and sediment concentrations of plutonium were used to model dispersal and deposition of windblown residual plutonium, as a function of distance and direction. Environmental disturbances that affected vegetation cover included ground fire, crown fire, and drought, with reoccurrence rates for current climate based on site historical

  11. Application of Normal Distribution Model to Estimate Root Water Uptake Profile by an Isotopic Approach

    Science.gov (United States)

    Yamanaka, T.; Matsuo, D.; Hirota, M.

    2008-12-01

    To confirm usefulness of a diagnostic model for estimating root water uptake profile by an isotopic approach, isotopic measurements of plant xylem water, soil water and groundwater were conducted at seven Japanese red pine forest sites and then the model was applied to the measured results. The model assumes that depth profile of relative uptake rate can be approximated by the normal distribution function, and xylem water isotopic composition is computed from interpolated depth profile of isotopic composition of subsurface waters. The peak depth and distribution range of water uptake zone for a given species at a given site are inversely determined by direct search method (assuming depth interval of 5 cm up to 2 m) so as to minimize root mean square error throughout observation period. Estimated water uptake profiles showed that in six sites the uptake zone of Japanese red pine (Pinus densiflora) ranged from 5 to 60 cm depth, while it was changed to deeper depths in the other site where Quercus myrsinaefolia and Pleioblastus chino coexist. On the other hand, Populus sieboldi and Malus sieboldii take up water from depths deeper than those for Pinus densiflora within a community, although the two species are usually considered as shallow rooted plants. These results indicate water source partitioning under inter-species competition, and we conclude that the present model is capable of making clear the plant water use strategy. Estimated water uptake zone also provides useful information for improving/calibrating prognostic, physical models of root water uptake.

  12. Direct radiative effect modeled for regional aerosols in central Europe including the effect of relative humidity

    Science.gov (United States)

    Iorga, G.; Hitzenberger, R.; Kasper-Giebl, A.; Puxbaum, Hans

    2007-01-01

    In view of both the climatic relevance of aerosols and the fact that aerosol burdens in central Europe are heavily impacted by anthropogenic sources, this study is focused on estimating the regional-scale direct radiative effect of aerosols in Austria. The aerosol data (over 80 samples in total) were collected during measurement campaigns at five sampling sites: the urban areas of Vienna, Linz, and Graz and on Mt. Rax (1644 m, regional background aerosol) and Mt. Sonnblick (3106 m, background aerosol). Aerosol mass size distributions were obtained with eight-stage (size range: 0.06-16 μm diameter) and six-stage (size range 0.1-10 μm) low-pressure cascade impactors. The size-segregated samples were analyzed for total carbon (TC), black carbon (BC), and inorganic ions. The aerosol at these five locations is compared in terms of size distributions, optical properties, and direct forcing. Mie calculations are performed for the dry aerosol at 60 wavelengths in the range 0.3-40 μm. Using mass growth factors determined earlier, the optical properties are also estimated for higher relative humidities (60%, 70%, 80%, and 90%). A box model was used to estimate direct radiative forcing (DRF). The presence of absorbing species (BC) was found to reduce the cooling effect of the aerosols. The water-soluble substances dominate radiative forcing at the urban sites, while on Rax and Sonnblick BC plays the most important role. This result can be explained by the effect of the surface albedo, which is much lower in the urban regions (0.16) than at the ice and snow-covered mountain sites. Shortwave (below 4 μm) and longwave surface albedo values for ice were 0.35 and 0.5, while for snow surface albedo, values of 0.8 (shortwave) and 0.5 (longwave) were used. In the case of dry aerosol, especially for urban sites, the unidentified material may contribute a large part to the forcing. Depending on the sampling site the estimated forcing gets more negative with increasing humidity

  13. Clarifying the use of aggregated exposures in multilevel models: self-included vs. self-excluded measures.

    Directory of Open Access Journals (Sweden)

    Etsuji Suzuki

    Full Text Available BACKGROUND: Multilevel analyses are ideally suited to assess the effects of ecological (higher level and individual (lower level exposure variables simultaneously. In applying such analyses to measures of ecologies in epidemiological studies, individual variables are usually aggregated into the higher level unit. Typically, the aggregated measure includes responses of every individual belonging to that group (i.e. it constitutes a self-included measure. More recently, researchers have developed an aggregate measure which excludes the response of the individual to whom the aggregate measure is linked (i.e. a self-excluded measure. In this study, we clarify the substantive and technical properties of these two measures when they are used as exposures in multilevel models. METHODS: Although the differences between the two aggregated measures are mathematically subtle, distinguishing between them is important in terms of the specific scientific questions to be addressed. We then show how these measures can be used in two distinct types of multilevel models-self-included model and self-excluded model-and interpret the parameters in each model by imposing hypothetical interventions. The concept is tested on empirical data of workplace social capital and employees' systolic blood pressure. RESULTS: Researchers assume group-level interventions when using a self-included model, and individual-level interventions when using a self-excluded model. Analytical re-parameterizations of these two models highlight their differences in parameter interpretation. Cluster-mean centered self-included models enable researchers to decompose the collective effect into its within- and between-group components. The benefit of cluster-mean centering procedure is further discussed in terms of hypothetical interventions. CONCLUSIONS: When investigating the potential roles of aggregated variables, researchers should carefully explore which type of model-self-included or self

  14. A gamma variate model that includes stretched exponential is a better fit for gastric emptying data from mice.

    Science.gov (United States)

    Bajzer, Željko; Gibbons, Simon J; Coleman, Heidi D; Linden, David R; Farrugia, Gianrico

    2015-08-01

    Noninvasive breath tests for gastric emptying are important techniques for understanding the changes in gastric motility that occur in disease or in response to drugs. Mice are often used as an animal model; however, the gamma variate model currently used for data analysis does not always fit the data appropriately. The aim of this study was to determine appropriate mathematical models to better fit mouse gastric emptying data including when two peaks are present in the gastric emptying curve. We fitted 175 gastric emptying data sets with two standard models (gamma variate and power exponential), with a gamma variate model that includes stretched exponential and with a proposed two-component model. The appropriateness of the fit was assessed by the Akaike Information Criterion. We found that extension of the gamma variate model to include a stretched exponential improves the fit, which allows for a better estimation of T1/2 and Tlag. When two distinct peaks in gastric emptying are present, a two-component model is required for the most appropriate fit. We conclude that use of a stretched exponential gamma variate model and when appropriate a two-component model will result in a better estimate of physiologically relevant parameters when analyzing mouse gastric emptying data.

  15. Distributional Assumptions in Educational Assessments Analysis: Normal Distributions versus Generalized Beta Distribution in Modeling the Phenomenon of Learning

    Science.gov (United States)

    Campos, Jose Alejandro Gonzalez; Moraga, Paulina Saavedra; Del Pozo, Manuel Freire

    2013-01-01

    This paper introduces the generalized beta (GB) model as a new modeling tool in the educational assessment area and evaluation analysis, specifically. Unlike normal model, GB model allows us to capture some real characteristics of data and it is an important tool for understanding the phenomenon of learning. This paper develops a contrast with the…

  16. Including the effects of filamentous bulking sludge during the simulation of wastewater treatment plants using a risk assessment model

    DEFF Research Database (Denmark)

    Flores Alsina, Xavier; Comas, J.; Rodriquez-Roda, I.

    2009-01-01

    The main objective of this paper is to demonstrate how including the occurrence of filamentous bulking sludge in a secondary clarifier model will affect the predicted process performance during the simulation of WWTPs. The IWA Benchmark Simulation Model No. 2 (BSM2) is hereby used as a simulation...

  17. The joint structure of normal and pathological personality: further evidence for a dimensional model.

    Science.gov (United States)

    Hengartner, Michael P; Ajdacic-Gross, Vladeta; Rodgers, Stephanie; Müller, Mario; Rössler, Wulf

    2014-04-01

    The literature proposes a joint structure of normal and pathological personality with higher-order factors mainly based on the five-factor model of personality (FFM). The purpose of the present study was to examine the joint structure of the FFM and the DSM-IV personality disorders (PDs) and to discuss this structure with regard to higher-order domains commonly reported in the literature. We applied a canonical correlation analysis, a series of principal component analyses with oblique Promax rotation and a bi-factor analysis with Geomin rotation on 511 subjects of the general population of Zurich, Switzerland, using data from the ZInEP Epidemiology Survey. The 5 FFM traits and the 10 DSM-IV PD dimensions shared 77% of total variance. Component extraction tests pointed towards a two- and three-component solution. The two-component solution comprised a first component with strong positive loadings on neuroticism and all 10 PD dimensions and a second component with strong negative loadings on extraversion and openness and positive loadings on schizoid and avoidant PDs. The three-component solution added a third component with strong positive loadings on conscientiousness and agreeableness and a negative loading on antisocial PD. The bi-factor model provided evidence for 1 general personality dysfunction factor related to neuroticism and 5 group factors, although the interpretability of the latter was limited. Normal and pathological personality domains are not isomorphic or superposable, although they share a substantial proportion of variance. The two and three higher-order domains extracted in the present study correspond well to equivalent factor-solutions reported in the literature. Moreover, these superordinate factors can consistently be integrated within a hierarchical structure of alternative four- and five-factor models. The top of the hierarchy presumably constitutes a general personality dysfunction factor which is closely related to neuroticism. © 2014.

  18. PREDICTION OF BLOOD PATTERN IN S-SHAPED MODEL OF ARTERY UNDER NORMAL BLOOD PRESSURE

    Directory of Open Access Journals (Sweden)

    Mohd Azrul Hisham Mohd Adib

    2013-06-01

    Full Text Available Athletes are susceptible to a wide variety of traumatic and non-traumatic vascular injuries to the lower limb. This paper aims to predict the three-dimensional flow pattern of blood through an S-shaped geometrical artery model. This model has created by using Fluid Structure Interaction (FSI software. The modeling of the geometrical S-shaped artery is suitable for understanding the pattern of blood flow under constant normal blood pressure. In this study, a numerical method is used that works on the assumption that the blood is incompressible and Newtonian; thus, a laminar type of flow can be considered. The authors have compared the results with a previous study with FSI validation simulation. The validation and verification of the simulation studies is performed by comparing the maximum velocity at t = 0.4 s, because at this time, the blood accelerates rapidly. In addition, the resulting blood flow at various times, under the same boundary conditions in the S-shaped geometrical artery model, is presented. The graph shows that velocity increases linearly with time. Thus, it can be concluded that the flow of blood increases with respect to the pressure inside the body.

  19. Modeling the Philippines' real gross domestic product: A normal estimation equation for multiple linear regression

    Science.gov (United States)

    Urrutia, Jackie D.; Tampis, Razzcelle L.; Mercado, Joseph; Baygan, Aaron Vito M.; Baccay, Edcon B.

    2016-02-01

    The objective of this research is to formulate a mathematical model for the Philippines' Real Gross Domestic Product (Real GDP). The following factors are considered: Consumers' Spending (x1), Government's Spending (x2), Capital Formation (x3) and Imports (x4) as the Independent Variables that can actually influence in the Real GDP in the Philippines (y). The researchers used a Normal Estimation Equation using Matrices to create the model for Real GDP and used α = 0.01.The researchers analyzed quarterly data from 1990 to 2013. The data were acquired from the National Statistical Coordination Board (NSCB) resulting to a total of 96 observations for each variable. The data have undergone a logarithmic transformation particularly the Dependent Variable (y) to satisfy all the assumptions of the Multiple Linear Regression Analysis. The mathematical model for Real GDP was formulated using Matrices through MATLAB. Based on the results, only three of the Independent Variables are significant to the Dependent Variable namely: Consumers' Spending (x1), Capital Formation (x3) and Imports (x4), hence, can actually predict Real GDP (y). The regression analysis displays that 98.7% (coefficient of determination) of the Independent Variables can actually predict the Dependent Variable. With 97.6% of the result in Paired T-Test, the Predicted Values obtained from the model showed no significant difference from the Actual Values of Real GDP. This research will be essential in appraising the forthcoming changes to aid the Government in implementing policies for the development of the economy.

  20. IL-1RI participates in normal growth plate development and bone modeling.

    Science.gov (United States)

    Simsa-Maziel, Stav; Zaretsky, Janna; Reich, Adi; Koren, Yoav; Shahar, Ron; Monsonego-Ornan, Efrat

    2013-07-01

    The proinflammatory cytokine interleukin-1 (IL-1) signals through IL-1 receptor type I (IL-1RI) and induces osteoclastogenesis and bone resorption mainly during pathological conditions. Little is known about the effect of excess or absence of IL-1 signaling on the physiological development of the growth plate and bone. In this study, we examine growth plate morphology, bone structure, and mechanical properties as well as osteoclast number in IL-1RI knockout mice to evaluate the role of IL-1RI in the normal development of the growth plate and bone. We show for the first time that IL-1RI knockout mice have narrower growth plates due to a smaller hypertrophic zone, suggesting a role for this cytokine in hypertrophic differentiation, together with higher proteoglycan content. The bones of theses mice exhibit higher trabecular and cortical mass, increased mineral density, and superior mechanical properties. In addition, IL-1RI knockout mice have significantly reduced osteoclast numbers in the chondro-osseous junction, trabecular bone, and cortical bone. These results suggest that IL-1RI is involved in normal growth plate development and ECM homeostasis and that it is significant in the physiological process of bone modeling.