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Sample records for mm ho ca

  1. HoCaMA: Home Care Hybrid Multiagent Architecture

    Science.gov (United States)

    Fraile, Juan A.; Bajo, Javier; Abraham, Ajith; Corchado, Juan M.

    Home Care is one of the main objectives of Ambient Intelligence. Nowadays, the disabled and elderly population, which represents a significant part of our society, requires novel solutions for providing home care in an effective way. In this chapter, we present HoCaMA, a hybrid multiagent architecture that facilitates remote monitoring and care services for disabled patients at their homes. HoCaMA combines multiagent systems and Web services to facilitate the communication and integration with multiple health care systems. In addition, HoCaMA focuses on the design of reactive agents capable of interacting with different sensors present in the environment, and incorporates a system of alerts through SMS and MMS mobile technologies. Finally, it uses Radio Frequency IDentification and JavaCard technologies to provide advanced location and identification systems, as well as automatic access control facilities. HoCaMA has been implemented in a real environment and the results obtained are presented within this chapter.

  2. Adapting TESLA technology for future cw light sources using HoBiCaT

    Science.gov (United States)

    Kugeler, O.; Neumann, A.; Anders, W.; Knobloch, J.

    2010-07-01

    The HoBiCaT facility has been set up and operated at the Helmholtz-Zentrum-Berlin and BESSY since 2005. Its purpose is testing superconducting cavities in cw mode of operation and it was successfully demonstrated that TESLA pulsed technology can be used for cw mode of operation with only minor changes. Issues that were addressed comprise of elevated dynamic thermal losses in the cavity walls, necessary modifications in the cryogenics and the cavity processing, the optimum choice of operational parameters such as cavity temperature or bandwidth, the characterization of higher order modes in the cavity, and the usability of existing tuners and couplers for cw.

  3. Valence band electronic structure of Ho-doped La0.67Ca0.33MnO3 using ultra-violet photoemission spectroscopy

    Science.gov (United States)

    Rout, S. K.; Mukharjee, R. N.; Mishra, D. K.; Roul, B. K.; Sekhar, B. R.; Dalai, M. K.

    2017-05-01

    In this manuscript we report the valence band electronic structure of Ho doped La0.67Ca0.33MnO3 using ultraviolet photoemission spectroscopy. We compared the density of states of La0.67Ca0.33MnO3, La0.67Ca0.3Ho0.03MnO3 and La0.64Ho0.03Ca0.33MnO3 near the Fermi level at various temperatures. Significant amount of changes have been observed at higher temperatures (220 K and 300 K) where the near Fermi level density of states increases with Ho doping into La0.67Ca0.33MnO3 indicating the enhancement of magnitude of change in metallicity (conductivity).

  4. Subsolidus Phase Relations of the CaO-REOx-CuO Systems (RE = Eu, Tb, Dy, Ho, Er, Lu and Sc) at 900 °C in Air

    DEFF Research Database (Denmark)

    Grivel, Jean-Claude

    2016-01-01

    The subsolidus phase relations of the CaO-REOx-CuO systems (RE = Eu, Tb, Dy, Ho, Er, Lu and Sc) were investigated in air at 900 °C. The pseudo-ternary sections with RE = Tb, Dy, Ho, Er and Lu have a similar structure. They have in common with the RE = Eu system a solid solution of Ca0.833−xRExCuO2......+y composition but the system with RE = Eu differs by the presence of an Eu2CuO4 phase instead of RE2Cu2O5 for RE = Tb, Dy, Ho, Er and Lu. In contrast, the CaO-ScO1.5-CuO section does not contain a Ca0.833−xScxCuO2+y solid solution and is dominated by the CaSc2O4 phase, which has no equivalent...... in the other systems at 900 °C in air....

  5. AN UNBIASED 1.3 mm EMISSION LINE SURVEY OF THE PROTOPLANETARY DISK ORBITING LkCa 15

    Energy Technology Data Exchange (ETDEWEB)

    Punzi, K. M.; Kastner, J. H. [Center for Imaging Science, School of Physics and Astronomy, and Laboratory for Multiwavelength Astrophysics, Rochester Institute of Technology, 54 Lomb Memorial Drive, Rochester, NY 14623 (United States); Hily-Blant, P.; Forveille, T. [UJF—Grenoble 1/CNRS-INSU, Institut de Planétologie et d’Astrophysique de Grenoble (IPAG) UMR 5274, F-38041, Grenoble (France); Sacco, G. G. [INAF—Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-50125, Firenze (Italy)

    2015-06-01

    The outer (>30 AU) regions of the dusty circumstellar disk orbiting the ∼2–5 Myr old, actively accreting solar analog LkCa 15 are known to be chemically rich, and the inner disk may host a young protoplanet within its central cavity. To obtain a complete census of the brightest molecular line emission emanating from the LkCa 15 disk over the 210–270 GHz (1.4–1.1 mm) range, we have conducted an unbiased radio spectroscopic survey with the Institute de Radioastronomie Millimétrique (IRAM) 30 m telescope. The survey demonstrates that in this spectral region, the most readily detectable lines are those of CO and its isotopologues {sup 13}CO and C{sup 18}O, as well as HCO{sup +}, HCN, CN, C{sub 2}H, CS, and H{sub 2}CO. All of these species had been previously detected in the LkCa 15 disk; however, the present survey includes the first complete coverage of the CN (2–1) and C{sub 2}H (3–2) hyperfine complexes. Modeling of these emission complexes indicates that the CN and C{sub 2}H either reside in the coldest regions of the disk or are subthermally excited, and that their abundances are enhanced relative to molecular clouds and young stellar object environments. These results highlight the value of unbiased single-dish line surveys in guiding future high-resolution interferometric imaging of disks.

  6. Tunable multicolor and enhanced red emission of monodisperse CaF2:Yb3+/Ho3+ microspheres via Mn2+ doping

    Science.gov (United States)

    Wang, Rui; Yuan, Maohui; Zhang, Chaofan; Wang, Hongyan; Xu, Xiaojun

    2018-05-01

    Transition metal ions (e.g. Mn2+) and lanthanide co-doped upconversion (UC) materials have attracted wide attention in recent years due to their promising application in multicolor display. Here, we report the hydrothermal synthesis and characterization of Mn2+ doped monodisperse CaF2:Yb3+/Ho3+ microspheres. The results of X-ray diffraction (XRD) revealed that Mn2+ doping does not change the cubic phase of CaF2 material but will lead to diffraction peaks shifting slightly towards higher angle due to the substitution of larger Ca2+ by the relatively smaller Mn2+. Under the excitation of 980 nm continuous wave (CW) laser, these microspheres exhibit green-yellow-red tuning colors and remarkable enhancement of both red to green ratio (R/G) and red to blue ratio (R/B) when increasing Mn2+ concentration from 0 to 30 mol%. The energy migration process between Ho3+ and Mn2+ was proposed and supported by time-decay and power dependence measurements of Ho3+ UC emission. These upconversion materials may have potential applications in optical devices, color display, nanoscale lasers and biomedical imaging.

  7. White light emission and effect of annealing on the Ho3+–Yb3+ codoped BaCa2Al8O15 phosphor

    International Nuclear Information System (INIS)

    Kumari, Astha; Rai, Vineet Kumar

    2015-01-01

    Graphical abstract: The upconversion emission spectra of the Ho 3+ /Yb 3+ doped/codoped BaCa 2 Al 8 O 15 phosphors with different doping concentrations of Ho 3+ /Yb 3+ ions along with UC emission spectrum of the white light emitting phosphor annealed at 800 °C. - Highlights: • BaCa 2 Al 8 O 15 phosphors codoped with Ho 3+ –Yb 3+ have been prepared by combustion method. • Phosphor annealed at 800 °C, illuminate an intense white light upon NIR excitation. • The sample annealed at higher temperatures emits in the pure green region. • The colour emitted persists in the white region even at high pump power density. • Developed phosphor is suitable for making upconverters and WLEDs. - Abstract: The BaCa 2 Al 8 O 15 (BCAO) phosphors codoped with suitable Ho 3+ –Yb 3+ dopant concentration prepared by combustion method illuminate an intense white light upon near infrared diode laser excitation. The structural analysis of the phosphors and the detection of impurity contents have been performed by using the X-Ray Diffraction, FESEM and FTIR analysis. The purity of white light emitted from the sample has been confirmed by the CIE chromaticity diagram. Also, the white light emitted from the sample persists with the variation of pump power density. The phosphors emit upconversion (UC) emission bands in the blue, green and red region (three primary colours required for white light emission) along with one more band in the near infrared region of the electromagnetic spectrum. On annealing the white light emitting sample at higher temperatures, the sample starts to emit green colour and also the intensity of green and red UC emission bands get enhanced largely.

  8. Electronic and magnetic properties of R0.5A0.5MnO3 compounds (R=Gd, Dy, Ho, Er; A=Sr, Ca)

    International Nuclear Information System (INIS)

    Terai, T.; Sasaki, T.; Kakeshita, T.; Fukuda, T.; Saburi, T.; Kitagawa, H.; Kindo, K.; Honda, M.

    2000-01-01

    Electronic and magnetic properties of the perovskitelike compounds of R 0.5 A 0.5 MnO 3 (R=Gd, Dy, Ho, Er; A=Sr, Ca) have been studied by measuring lattice parameter, electrical resistivity, magnetic susceptibility, and magnetization. All the Sr-doped compounds show a transition from a paramagnetic insulator to a spin-glass-like insulator at T g , even though the manganite La 0.5 Ca 0.5 MnO 3 , with nearly the same tolerance factor t, have been shown by others, to have different transitions. On the other hand, all the Ca-doped compounds show a charge-ordering transition at T CO and show a transition from a paramagnetic insulator to a canted antiferromagnetic insulator and/or a spin-glass-like insulator at T CA below T CO . These transition temperatures decrease with decreasing t. In the compound of Gd 0.5 Ca 0.5 MnO 3 , the collapse of the charge ordering has been observed under a pulsed high magnetic field of 45 T at 4.2 K. On the other hand, in the compound of Gd 0.5 Sr 0.5 MnO 3 , the magnetization process depends on the strength of magnetic field. These electronic and magnetic properties depend not only on the tolerance factor but also the variance (second moment) of the A-site ion radii distribution

  9. Effect of concentration variation on 2.0 µm emission of Ho3+-doped SiO2-Al2O3-Na2CO3-SrF2-CaF2 oxyfluorosilicate glasses

    Science.gov (United States)

    Gelija, Devarajulu; Borelli, Deva Prasad Raju

    2018-02-01

    The concentration variation of Ho3+ ion-doped SiO2-Al2O3-Na2CO3-SrF2-CaF2 glasses has been prepared by conventional melt quenching method. The thermal stability of 1 mol % of Ho3+-doped oxyfluorosilicate glass has been calculated using the differential thermal analysis (DTA) spectra. The phenomenological Judd-Ofelt intensity parameters Ωλ ( λ = 2, 4 and 6) were calculated for all concentrations of Ho3+ ions. The luminescence spectra in visible region of Ho3+ ion-doped glasses were recorded under the excitation wavelength of 452 nm. The spectra consists of several intense emission bands (5F4, 5S2) → 5I8 (547 nm), 5F3 → 5I8 (647 nm), 5F5 → 5I7 (660 nm) and (5F4, 5S2) → 5I7 (750 nm) in the range 500-780 nm. The fluorescence emission at ˜2.0 µm (5I7 → 5I8) was observed under the excitation of 488 nm Ar-ion laser. The stimulated emission cross section for 5I7 → 5I8 transition (˜2.0 µm) varies from 8.46 to 9.52 × 10-21 cm2, as calculated by the Fuchtbauer-Ladenburg (FL) theory. However, Mc-Cumber theory was used to calculate emission cross section values about 4.24-5.75 × 10-21 cm2 for the 5I7 → 5I8 transition in all concentrations of Ho3+-doped oxyfluorosilicate glasses. Therefore, these results reveal that the 0.5 mol % of Ho3+-doped oxyfluorosilicate glasses, exhibiting higher emission cross section, has potentially been used for laser applications at ˜ 2.0 µm.

  10. Effect of concentration variation on 2.0 μm emission of Ho3+-doped SiO2-Al2O3-Na2CO3-SrF2-CaF2 oxyfluorosilicate glasses

    International Nuclear Information System (INIS)

    Gelija, Devarajulu; Borelli, Deva Prasad Raju

    2018-01-01

    The concentration variation of Ho 3+ ion-doped SiO 2 -Al 2 O 3 -Na 2 CO 3 -SrF 2 -CaF 2 glasses has been prepared by conventional melt quenching method. The thermal stability of 1 mol % of Ho 3+ -doped oxyfluorosilicate glass has been calculated using the differential thermal analysis (DTA) spectra. The phenomenological Judd-Ofelt intensity parameters Ω λ (λ = 2, 4 and 6) were calculated for all concentrations of Ho 3+ ions. The luminescence spectra in visible region of Ho 3+ ion-doped glasses were recorded under the excitation wavelength of 452 nm. The spectra consists of several intense emission bands ( 5 F 4 , 5 S 2 ) → 5 I 8 (547 nm), 5 F 3 → 5 I 8 (647 nm), 5 F 5 → 5 I 7 (660 nm) and ( 5 F 4 , 5 S 2 ) → 5 I 7 (750 nm) in the range 500-780 nm. The fluorescence emission at ∝ 2.0 μm ( 5 I 7 → 5 I 8 ) was observed under the excitation of 488 nm Ar-ion laser. The stimulated emission cross section for 5 I 7 → 5 I 8 transition (∝ 2.0 μm) varies from 8.46 to 9.52 x 10 -21 cm 2 , as calculated by the Fuchtbauer-Ladenburg (FL) theory. However, Mc-Cumber theory was used to calculate emission cross section values about 4.24-5.75 x 10 -21 cm 2 for the 5 I 7 → 5 I 8 transition in all concentrations of Ho 3+ -doped oxyfluorosilicate glasses. Therefore, these results reveal that the 0.5 mol % of Ho 3+ -doped oxyfluorosilicate glasses, exhibiting higher emission cross section, has potentially been used for laser applications at ∝ 2.0 μm. (orig.)

  11. Forward scattering amplitudes for π+- on Al, Ca, Cu, Sn, Ho, and Pb in the energy range 114-215 MeV

    International Nuclear Information System (INIS)

    Jeppesen, R.H.

    1980-01-01

    Measurements have been made of the attenuation cross section, sigma(Ω), for both π + and π- projectiles on Al, 40 Ca, Cu, Sn, Ho, and Pb nuclei. The measurements were made over a range of energies including 114, 140, 165, and 215 MeV. A new method of analyzing transmission experiments data has been used to extract both the real and the imaginary parts of a forward scattering amplitude f/sub N/(0), where f/sub N/(0) is defined to be the limit as Ω → 0 of F(Ω)-f/sub c/(Ω). F(Ω) is the full elastic scattering amplitude and f/sub c/(Ω) is the relativistic point Coulomb amplitude. The values of f/sub N/(0) are compared with forward amplitudes from model calculation. These comparisons demonstrate that much of the observed rotation of the forward scattering amplitude, when plotted in the Argand plane, can be attributed to the Coulomb phase contained in the definition of f/sub N/(0). Results are also compared to those of other experiments. A difference is observed in attenuation measurements between this experiment and a Brookhaven experiment which measured total cross sections on Pb, Sn, and Al. There have been only a few published results in which experimental values of f/sub N/(0) are given. In those cases, general agreement is obsserved with the results of this experiment

  12. White light emission and effect of annealing on the Ho{sup 3+}–Yb{sup 3+} codoped BaCa{sub 2}Al{sub 8}O{sub 15} phosphor

    Energy Technology Data Exchange (ETDEWEB)

    Kumari, Astha; Rai, Vineet Kumar, E-mail: vineetkrrai@yahoo.co.in

    2015-12-15

    Graphical abstract: The upconversion emission spectra of the Ho{sup 3+}/Yb{sup 3+} doped/codoped BaCa{sub 2}Al{sub 8}O{sub 15} phosphors with different doping concentrations of Ho{sup 3+}/Yb{sup 3+} ions along with UC emission spectrum of the white light emitting phosphor annealed at 800 °C. - Highlights: • BaCa{sub 2}Al{sub 8}O{sub 15} phosphors codoped with Ho{sup 3+}–Yb{sup 3+} have been prepared by combustion method. • Phosphor annealed at 800 °C, illuminate an intense white light upon NIR excitation. • The sample annealed at higher temperatures emits in the pure green region. • The colour emitted persists in the white region even at high pump power density. • Developed phosphor is suitable for making upconverters and WLEDs. - Abstract: The BaCa{sub 2}Al{sub 8}O{sub 15} (BCAO) phosphors codoped with suitable Ho{sup 3+}–Yb{sup 3+} dopant concentration prepared by combustion method illuminate an intense white light upon near infrared diode laser excitation. The structural analysis of the phosphors and the detection of impurity contents have been performed by using the X-Ray Diffraction, FESEM and FTIR analysis. The purity of white light emitted from the sample has been confirmed by the CIE chromaticity diagram. Also, the white light emitted from the sample persists with the variation of pump power density. The phosphors emit upconversion (UC) emission bands in the blue, green and red region (three primary colours required for white light emission) along with one more band in the near infrared region of the electromagnetic spectrum. On annealing the white light emitting sample at higher temperatures, the sample starts to emit green colour and also the intensity of green and red UC emission bands get enhanced largely.

  13. Improved ferroelectric/piezoelectric properties and bright green/UC red emission in (Li,Ho)-doped CaBi4Ti4O15 multifunctional ceramics with excellent temperature stability and superior water-resistance performance.

    Science.gov (United States)

    Xiao, Ping; Guo, Yongquan; Tian, Mijie; Zheng, Qiaoji; Jiang, Na; Wu, Xiaochun; Xia, Zhiguo; Lin, Dunmin

    2015-10-21

    Multifunctional materials based on rare earth ion doped ferro/piezoelectrics have attracted considerable attention in recent years. In this work, new lead-free multifunctional ceramics of Ca1-x(LiHo)x/2Bi4Ti4O15 were prepared by a conventional solid-state reaction method. The great multi-improvement in ferroelectricity/piezoelectricity, down/up-conversion luminescence and temperature stability of the multifunctional properties is induced by the partial substitution of (Li0.5Ho0.5)(2+) for Ca(2+) ions in CaBi4Ti4O15. All the ceramics possess a bismuth-layer structure, and the crystal structure of the ceramics is changed from a four layered bismuth-layer structure to a three-layered structure with the level of (Li0.5Ho0.5)(2+) increasing. The ceramic with x = 0.1 exhibits simultaneously, high resistivity (R = 4.51 × 10(11)Ω cm), good piezoelectricity (d33 = 10.2 pC N(-1)), high Curie temperature (TC = 814 °C), strong ferroelectricity (Pr = 9.03 μC cm(-2)) and enhanced luminescence. These behaviours are greatly associated with the contribution of (Li0.5Ho0.5)(2+) in the ceramics. Under the excitation of 451 nm light, the ceramic with x = 0.1 exhibits a strong green emission peak centered at 545 nm, corresponding to the transition of the (5)S2→(5)I8 level in Ho(3+) ions, while a strong red up-conversion emission band located at 660 nm is observed under the near-infrared excitation of 980 nm at room temperature, arising from the transition of (5)F5→(5)I8 levels in Ho(3+) ions. Surprisingly, the excellent temperature stability of ferroelectricity/piezoelectricity/luminescence and superior water-resistance behaviors of piezoelectricity/luminescence are also obtained in the ceramic with x = 0.1. Our study suggests that the present ceramics may have potential applications in advanced multifunctional devices at high temperature.

  14. Performance evaluation of vertical feed fully automated TLD badge reader using 0.8 and 0.4 mm teflon embedded CaSO4:Dy dosimeters

    International Nuclear Information System (INIS)

    Ratna, P.; More, Vinay; Kulkarni, M.S.

    2012-01-01

    The personnel monitoring of more than 80,000 radiation workers in India is at present carried out by semi-automated TLD badge Reader systems (TLDBR-7B) developed by Radiation Safety Systems Division, Bhabha Atomic Research Centre. More than 60 such reader systems are in use in all the personnel monitoring centers in the country. Radiation Safety Systems Division also developed the fully automated TLD badge reader based on a new TLD badge having built-in machine readable ID code (in the form of 16x3 hole pattern). This automated reader is designed with minimum of changes in the electronics and mechanical hardware in the semiautomatic version (TLDBR-7B) so that such semi-automatic readers can be easily upgraded to the fully automated versions by using the new TLD badge with ID code. The reader was capable of reading 50 TLD cards in 90 minutes. Based on the feedback from the users, a new model of frilly automated TLD badge Reader (model VEFFA-10) is designed which is an improved version of the previously reported fully Automated TLD badge reader. This VEFFA-10 PC based Reader incorporates vertical loading of TLD bards having machine readable ID code. In this new reader, a vertical rack, which can hold 100 such cards, is mounted from the right side of the reader system. The TLD card falls into the channel by gravity from where it is taken to the reading position by rack and pinion method. After the readout, the TLD card is dropped in a eject tray. The reader employs hot N 2 gas heating method and the gas flow is controlled by a specially designed digital gas flow meter on the front panel of the reader system. The system design is very compact and simple and card stuck up problem is totally eliminated in the reader system. The reader has a number of self-diagnostic features to ensure a high degree of reliability. This paper reports the performance evaluation of the Reader using 0.4 mm thick Teflon embedded CaSO 4 :Dy TLD cards instead of 0.8 mm cards

  15. Magnetization fluctuation analysis and superconducting parameters of La0.5RE0.5BaCaCu3O7-δ(RE=Y, Sm, Gd, Dy, Ho, Yb) superconductor

    International Nuclear Information System (INIS)

    Parra Vargas, C.A.; Pimentel, J.L.; Pureur, P.; Landinez Tellez, D.A.; Roa-Rojas, J.

    2009-01-01

    In this work we report the analysis of magnetization experimental data of the La 0.5 RE 0.5 BaCaCu 3 O 7-δ (RE=Y, Sm, Gd, Dy, Ho, Yb) superconducting system. The data are analyzed in terms of thermal fluctuations on the magnetization excess ΔM(T) for different values of temperature in each one of the samples. We describe a procedure for extracting the penetration depth λ ab (∼1571A) and the coherence length ξ ab (∼1.52A) parameters from the magnetization, as a function of the applied magnetic field. This procedure was performed for polycrystalline samples of La 0.5 RE 0.5 BaCaCu 3 O 7-δ by using the theory of Bulaevskii, Ledvij and Kogan, which analyzes the vortex fluctuation in superconducting materials within the Lawrence-Doniach framework. These data allowed to determine the characteristic temperature value T * (73, 58, 48, 57, 56, 71 K, for RE=Y, Sm, Gd, Dy, Ho, Yb, respectively) in the magnetization curves for several magnetic fields. We calculated the data of magnetization excess from the curves of magnetization as a function of logarithm of applied field. We notice that the values for these superconducting parameters are in agreement with the reports for high temperature superconductors. The obtained value of superconducting volumetric fraction is compared with that obtained through the measure of the Meissner effect.

  16. New orthorhombic derivative of CaCu{sub 5}-type structure: RNi{sub 4}Si compounds (R=Y, La, Ce, Sm, Gd–Ho), crystal structure and some magnetic properties

    Energy Technology Data Exchange (ETDEWEB)

    Morozkin, A.V., E-mail: morozkin@general.chem.msu.ru [Department of Chemistry, Moscow State University, Leninskie Gory, House 1, Building 3, GSP-2, Moscow 119992 (Russian Federation); Knotko, A.V. [Department of Chemistry, Moscow State University, Leninskie Gory, House 1, Building 3, GSP-2, Moscow 119992 (Russian Federation); Yapaskurt, V.O. [Department of Petrology, Geological Faculty, Moscow State University, Leninskie Gory, Moscow 119992 (Russian Federation); Yuan, Fang; Mozharivskyj, Y. [Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4M1 (Canada); Nirmala, R. [Indian Institute of Technology Madras, Chennai 600036 (India)

    2013-12-15

    The crystal structure of new YNi{sub 4}Si-type RNi{sub 4}Si (R=Y, La, Ce, Sm, Gd–Ho) compounds has been established using powder X-ray diffraction. The YNi{sub 4}Si structure is a new structure type, which is orthorhombic derivative of CaCu{sub 5}-type structure (space group Cmmm N 65, oC12). GdNi{sub 4}Si and DyNi{sub 4}Si compounds order ferromagnetically at 25 and 19 K, respectively whereas YNi{sub 4}Si shows antiferromagnetic nature. At 15 K, DyNi{sub 4}Si shows second antiferromagnetic-like transition. The magnetic moment of GdNi{sub 4}Si at 5 K in 50 kOe field is ∼7.2 μ{sub B}/f.u. suggesting a completely ordered ferromagnetic state. The magnetocaloric effect of GdNi{sub 4}Si is calculated in terms of isothermal magnetic entropy change and it reaches the maximum value of −12.8 J/kg K for a field change of 50 kOe near T{sub C} ∼25 K. - Graphical abstract: The RNi{sub 4}Si (R=Y, La, Ce, Sm, Gd–Ho) compounds crystallize in new YNi{sub 4}Si-type structure which is orthorhombic derivative of the basic CaCu{sub 5}-type structure. GdNi{sub 4}Si and DyNi{sub 4}Si compounds show the ferromagnetic-like ordering, whereas.YNi{sub 4}Si has the antiferromagnetic nature. The GdNi{sub 4}Si demonstrates the big magnetocaloric effect near temperature of ferromagnetic ordering. The relationship between initial CaCu{sub 5}-type DyNi{sub 5} and YNi{sub 4}Si-type DyNi{sub 4}Si lattices.

  17. Neutron powder diffraction investigation on the crystal and magnetic structure of (Ho{sub 0.50+x}Ca{sub 0.50-x})(Mn{sub 1-x}Cr{sub x})O{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Martinelli, A; Ferretti, M [SPIN-CNR, Corso Perrone 24, 16152 Genova (Italy); Castellano, C [Dipartimento di Chimica Strutturale e Stereochimica Inorganica, Universita degli Studi di Milano, Via C Venezian 21, 20133 Milano (Italy); Cimberle, M R; Masini, R [IMEM-CNR, Via Dodecaneso 33, 16146 Genova (Italy); Ritter, C, E-mail: alberto.martinelli@spin.cnr.it [Institute Laue-Langevin, 6 rue Jules Horowitz, 38042 Grenoble Cedex 9 (France)

    2011-10-19

    The crystal and magnetic structure of (Ho{sub 0.50+x}Ca{sub 0.50-x})(Mn{sub 1-x}Cr{sub x})O{sub 3} (x = 0.00, 0.01, 0.02, 0.03) has been investigated between 5 and 300 K by means of neutron powder diffraction followed by Rietveld refinement and dc magnetic measurements. During cooling an orthorhombic to monoclinic phase transition occurs on account of the charge and orbital ordering taking place in the Mn sub-lattice; at low temperature phase separation takes place and the main monoclinic phase coexists with a secondary orthorhombic phase, whose amount slightly increases with the increase of Cr content. Cr{sup 3+} is not involved in orbital ordering or superexchange interactions. The charge and magnetic ordering are decoupled: the Mn moments order according to a CE-type structure in all samples. (paper)

  18. Luminescence Properties of Self-Activated Mm(VO4)2 (M = Mg, Ca, Sr, and Ba) Phosphors Synthesized by Solid-State Reaction Method.

    Science.gov (United States)

    Min, Xin; Huang, Zhaohui; Fang, Minghao; Liu, Yan'gai; Tang, Chao; Wu, Xiaowen

    2016-04-01

    In this paper, M3(VO4)2 (M = Mg, Ca, Sr, and Ba) self-activated phosphors were prepared by a solid-state reaction method at 1,000 °C for 5 h. The phase formation and micrographs were analyzed by X-ray diffraction and scanning electron microscopy. The Ca3(VO4)2 phosphor does not show any emission peaks under excitation with ultraviolet (UV) light. However, the M3(VO4)2 (M = Mg, Sr, and Ba) samples are effectively excited by UV light chips ranging from 200 nm to 400 nm and exhibit broad emission bands due to the charge transfer from the oxygen 2p orbital to the vacant 3d orbital of the vanadium in the VO4. The color of these phosphors changes from yellow to light blue via blue-green with increasing ionic radius from Mg to Sr to Ba. The luminescence lifetimes and quantum yield decrease with the increasing unit cell volume and V-V distance, in the order of Mg3(VO4)2 to Sr3(VO4)2 to Ba3(VO4)2. The emission intensity decreases with the increase of temperatures, but presents no color shift. This confirms that these self-activated M3(VO4)2 phosphors can be suggested as candidates of the single-phase phosphors for light using UV light emitting diodes (LEDs).

  19. Enhancement of Mechanical Properties of Extruded Mg-9Al-1Zn-1MM-0.7CaO-0.3Mn Alloy Through Pre-aging Treatment

    Science.gov (United States)

    Jeong, Seok Hoan; Kim, Yong Joo; Kong, Kyung Ho; Cho, Tae Hee; Kim, Young Kyun; Lim, Hyun Kyu; Kim, Won Tae; Kim, Do Hyang

    2018-03-01

    The effect of pre-aging treatment before extrusion has been investigated in Mg-9.0Al-1.0Zn-1MM-0.7CaO-0.3Mn alloy. The as-cast microstructure consists of α-Mg dendrite with secondary solidification phase particles, (Mg, Al)2Ca, β-Mg17Al12 and Al11RE3 at the inter-dendritic region. After extrusion, β-Mg17Al12 precipitates are present, but higher density and more homogeneous distribution in pre-aged alloy. In addition, μm-scale banded bulk β-Mg17Al12 particles are generated during extrusion. Al11RE3 particles are broken into small particles, and are aligned along the extrusion direction. (Mg, Al)2Ca particles are only slightly elongated along the extrusion direction, providing stronger particle stimulated nucleation (PSN) effect by severe deformation during extrusion. The mechanical properties can be significantly enhanced by introducing pre-aging treatment, i.e. β-Mg17Al12 precipitates provide grain refining and strengthening effects and (Mg, Al)2Ca particles provide PSN effect.

  20. Návrh ubytovacího rezervačního internetového portálu

    OpenAIRE

    Čurilla, Miroslav

    2010-01-01

    Táto diplomová práca sa zaoberá návrhom ubytovacieho rezervačného internetového portálu. Cieľom práce je navrhnutie systému rezervovania ubytovania v ubytovacích zariadenia optimálnym spôsobom. Vedľajšími cieľmi je navrhnutie hardvérových, softvérových, bezpečnostných, marketingových a ekonomických riešení pri návrhu ubytovacieho rezervačné internetového portálu. This master’s thesis deals with the design of the internet portal for the reservation of accommodation. Its objective is the pro...

  1. Holmium laser lithotripsy (HoLL) of ureteral calculi

    Science.gov (United States)

    Kuntz, Rainer M.; Lehrich, Karin; Fayad, Amr

    2001-05-01

    The effectiveness and side effects of ureteroscopic HoLL of ureteral stones should be evaluated. In 63 patients (17 female, 46 males) a total of 75 stones of 3-20 mm diameter were treated with ureteroscopic HoLL. 18.7 percent of stones were located in the proximal third, 24.0 percent in the middle third and 57.3 percent in the distal third of the ureter. HoLL was performed with small diameter semirigid and flexible ureteroscopes, 220 or 365 nm flexible laser fibers and a holmium:YAG laser at a power of 5-15 W (0.5-1.0 J, 10- 15 Hz). 47 of 63 patients (74.6 percent) were immediately free of stones, and 8 others (12.6 percent) lost their residual fragments spontaneously within two weeks. Another 2 patients received additional chmolitholysis for uric acid stone fragments, i.e. 90.5 percent of patients were stone free by one sitting of ureterscopic HoLL. Of the remaining 6 patients (9.5 percent) who still had residual calculi 4 weeks after HoLL, 2 asymptomatic patients refused any additional treatment, 2 patients preferred treatment with ESWL, and 2 patients had a successful second HoLL, thereby raising the success rate of ureteroscopic HoLL to 93.7 percent. 2 patients showed contrast medium extravasation on retrograde ureterograms, due to guide wire perforation. No ureteral stricture occurred. In conclusion, transurethral ureteroscopic HoLL proved to be a safe and successful minimal invasive treatment of ureteral calculi.

  2. 2-mm microwave interferometer

    International Nuclear Information System (INIS)

    Futch, A.H.; Mortensen, W.K.

    1977-01-01

    A 2-mm microwave interferometer has been developed, and phase shift measurements have been made on the Baseball II experiment. The interferometer system employs a 140-GHz receiver for double down conversion of the plasma signal to a 60-MHz, IF frequency. The 140-GHz references signal is also down-converted and compared with the plasma signal to provide the desired phase change of the signal passing through the plasma. A feedback voltage from a 60-MHz discriminator to a voltage-controlled oscillator in the receiver provides frequency stability of the 60-MHz IF signals

  3. LiHo(PO34

    Directory of Open Access Journals (Sweden)

    Mokhtar Férid

    2009-02-01

    Full Text Available Lithium holmium(III polyphosphate(V, LiHo(PO34, belongs to the type I of polyphosphates with general formula ALn(PO34, where A is a monovalent cation and Ln is a trivalent rare earth cation. In the crystal structure, the polyphosphate chains spread along the b-axis direction, with a repeat period of four tetrahedra and 21 internal symmetry. The Li and Ho atoms are both located on twofold rotation axes and are surrounded by four and eight O atoms, leading to a distorted tetrahedral and dodecahedral coordination, respectively. The HoO8 polyhedra are isolated from each other, the closest Ho...Ho distance being 5.570 (1 Å.

  4. Experimental dosimetry of Ho-166 bioglass seed polymer-protected

    Energy Technology Data Exchange (ETDEWEB)

    Nogueira, Luciana B.; Campos, Tarcisio P.R. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Engenharia Nuclear. Programa de Pos-Graduacao em Ciencias e Tecnicas Nucleares

    2011-07-01

    This study aims to develop experimental dosimetry of Ho-166 bio glass seed for brachytherapy studies using GAFCHROMIC EBT2 radio chromium films. The methodology consists of placement of radio chromium films in a compressed breast phantom, along with bio glass polymer-protected seeds of [Si: Ca: Ho] and [Si: Ca: Ho: Zr]. The bio glass seeds were encapsulated with polyvinyl alcohol, before being activated and used in the study. The bio glass seeds were introduced into the breast phantom, along with radio chromium films for a period of 2 hours. After the exposure time, radio chromium films were removed from phantom and digitized for analysis in ImageDIG 2.0 program, which quantifies the intensity of RGB (Red, Green, Blue). The dose calculation was evaluated by Monte Carlo technique. Experimental and theoretical data were used to calibrate the dose distribution. The results were plotted on graphs and dose iso curves were obtained. As conclusion it is possible to perform dosimetry in Ho-166 seed brachytherapy using radio chromium films, limited to a short exposure time and small activity. (author)

  5. Experimental dosimetry of Ho-166 bioglass seed polymer-protected

    International Nuclear Information System (INIS)

    Nogueira, Luciana B.; Campos, Tarcisio P.R.

    2011-01-01

    This study aims to develop experimental dosimetry of Ho-166 bio glass seed for brachytherapy studies using GAFCHROMIC EBT2 radio chromium films. The methodology consists of placement of radio chromium films in a compressed breast phantom, along with bio glass polymer-protected seeds of [Si: Ca: Ho] and [Si: Ca: Ho: Zr]. The bio glass seeds were encapsulated with polyvinyl alcohol, before being activated and used in the study. The bio glass seeds were introduced into the breast phantom, along with radio chromium films for a period of 2 hours. After the exposure time, radio chromium films were removed from phantom and digitized for analysis in ImageDIG 2.0 program, which quantifies the intensity of RGB (Red, Green, Blue). The dose calculation was evaluated by Monte Carlo technique. Experimental and theoretical data were used to calibrate the dose distribution. The results were plotted on graphs and dose iso curves were obtained. As conclusion it is possible to perform dosimetry in Ho-166 seed brachytherapy using radio chromium films, limited to a short exposure time and small activity. (author)

  6. Konstrukce vřeten vícevřetenového soustružnického automatu

    OpenAIRE

    Kráčmar, Tomáš

    2016-01-01

    Obsahem diplomové práce je konstrukce vřeten vícevřetenového soustružnického automatu pro práci z tyče maximálního průměru 7 mm. Práce se zabývá novou koncepcí pohonu vřeten, kde jsou vřetena poháněna externími asynchronními motory přes ozubená kola s vnitřním ozubením uložená vně vřetenového bubnu namísto současného způsobu pohonu centrálními koaxiálními hřídeli. Součástí práce je rešerše vícevřetenových automatů včetně popisu hlavních uzlů, konstrukční návrh, pevnostní výpočty, výpočty trva...

  7. Shape coexistence in 153Ho

    International Nuclear Information System (INIS)

    Dey, Gautam; Sarkar, S.; Chakraborty, A.; Krishichayan; Ghugre, S.S.; Sinha, A.K.; Kshetri, Ritesh; Ray, I.; Ganguly, S.; Pradhan, M.K.; Raut, R.; Goswami, A.; Banerjee, P.; Mukherjee, A.; Bhattacharya, S.; Saha Sarkar, S.; Ray Basu, M.; Ganguly, G.; Ray, M.; Basu, S.K.

    2006-01-01

    The motivation for the present work are to firmly assign spins and parities of the excited levels and to investigate shape evolution in 153 Ho as expected phenomenologically from the level spectra and feeding patterns

  8. ILLICO-HO

    International Nuclear Information System (INIS)

    Ougouag, A.M.; Rajic, H.L.

    1988-01-01

    A self-consistent nodal method has been developed that directly computes the in-node flux shapes. The method renders the use of an approximation for the transverse leakages no longer necessary. These are obtained directly from the available interface net current shapes, interface flux shapes, and in-node fluxes. The order of the transverse leakage expansion on a set of Legendre polynomials is determined by the order chosen for the method. The results yielded are nearly as accurate (0.02% maximum relative assembly power error) as very fine-mesh benchmark solutions. A comprehensive numerical and analytical analysis of the transverse leakage approximation has been performed. It has been shown that the quadratic leakage approximation can be in error by many times its value. The success of the quadratic leakage approximation is attributed to its small effect on the nodal powers. The theory developed shows that the transverse leakages can have shapes that encompass hyperbolic sines and cosines, and hence that their approximation via quadratic expansions should not always be expected to be adequate. The ILLICO-HO method gives much more information (detailed fluxes and interface currents) than comparable finite difference as well as nodal benchmark solution methods

  9. Spectroscopy and microchip laser operation of Tm, Ho:KYW crystals with different Ho concentrations

    Science.gov (United States)

    Gusakova, N. V.; Kurilchik, S. V.; Yasukevich, A. S.; Kisel, V. E.; Dashkevich, V. I.; Orlovich, V. A.; Pavlyuk, A. A.; Vatnik, S. M.; Bagaev, S. N.; Kuleshov, N. V.

    2018-02-01

    The spectroscopic properties of Tm, Ho:KYW crystals with different Ho concentrations were investigated. The diode-pumped microchip laser operation of Tm (5 at.%), Ho (0.5 at.%):KYW and Tm (5 at.%), Ho (1 at.%):KYW was demonstrated. The highest, to our knowledge, output power of 480 mW with slope efficiency of 31% for CW Tm (5 at.%), Ho (0.5 at.%):KYW microchip laser was obtained.

  10. Podnikatelský plán - Založení internetového obchodu se sportovní halovou obuví

    OpenAIRE

    Možnár, Aleš

    2014-01-01

    Diplomová práca sa zaoberá zostavením realistického podnikateľského plánu na založenie internetového obchodu so športovou halovou obuvou. Podkladom pre návrh podnikateľského plánu je detailná analýza tržného prostredia a vlastných zdrojov. Cieľom tejto práce je posúdiť realizovateľnosť podnikateľského plánu, odhaliť jeho úzke miesta a riziká. The diploma thesis deals with formulating a realistic business plan for setting up online shop with indoor sport footware. This business plan proposa...

  11. Energy levels of Ho3+ in HoCl63-

    International Nuclear Information System (INIS)

    Tanner, P.A.

    1987-01-01

    The 5 S 2 , 5 F 4 , 5 F 2 , 3 K 8 , 5 G 6 , 5 F 1 , 5 G 5 5 I 8 absorption spectra of Cs 2 NaHoCl 6 have been recorded at temperatures down to that of liquid helium and new assignments are made for the 5 S 2 , 5 F 4 , 3 K 8 and 5 G 5 terms of HoCl 6 3- . The 5 F 3 → 5 I 8 , 5 F 4 , 5 S 2 → 5 I 7 , 5 I 8 and 5 F 5 → 5 I 7 luminescence transitions of HoCl 6 3- in various elpasolite lattices are reported and assigned, together with luminescence decay measurements. Including the previously reported data, these results enable 57 of the first 60 crystal-field levels of HoCl 6 3- , comprising 14 Lsub(j) terms, to be firmly assigned and tentative assignments are made for the remaining three levels. The agreement between the calculated and observed crystal-field splittings is reasonable. (author)

  12. Diode laser-pumped Ho:YLF laser

    International Nuclear Information System (INIS)

    Hemmati, H.

    1987-01-01

    The author reports laser action in Ho:YLF at 2.06 μm following optical pumping with a cw diode laser array. Diode laser-pumped Nd-YAG and Ho:YAG have been reported recently. Lasers with a wavelength of 2 μm have medical and optical communication applications. The diode laser light is focused with a 60-mm focal length lens onto the YLF crystal. A high-reflectivity mirror with 100-mm radius of curvature was used as the output coupler. The lasing threshold was at 5 mWof incident power. This is higher than expected considering that a high reflector was used as the output coupler. However, a more uniform cooling of the crystal is expected to lower the lasing threshold. With 100 mW of pump power coupled into the crystal, --20 mW of 2-μm radiation was observed from this unoptimized setup. The 2-μm laser output is highly sensitive to output coupler alignment, YLF crystal temperature, and pump laser wavelength. The 20% optical conversion efficiency achieved in his preliminary measurements is expected to be improved by better crystal cooling, proper matching of laser wavelength to crystal absorption, variations in the concentration of Ho and sensitizers and use of a proper output coupler. A study of the parameters mentioned above and the effect of crystal temperature on the laser output is under way

  13. On 165Ho level scheme

    International Nuclear Information System (INIS)

    Ardisson, Claire; Ardisson, Gerard.

    1976-01-01

    A 165 Ho level scheme was constructed which led to the interpretation of sixty γ rays belonging to the decay of 165 Dy. A new 702.9keV level was identified to be the 5/2 - member of the 1/2 ) 7541{ Nilsson orbit. )] [fr

  14. SSC 40 mm cable results and 50 mm design discussions

    International Nuclear Information System (INIS)

    Christopherson, D.; Capone, D.; Hannaford, R.; Remsbottom, R.; Delashmit, R.; Jayakumar, R.J.; Snitchler, G.; Scanlan, R.; Royet, J.

    1991-01-01

    This paper presents a summary of the cable produced for the 1990 40 mm Dipole Program. The cable design parameters for the 50 mm Dipole Program are discussed, as well as portions of the SSC specification draft. Considerations leading to the final cable configuration and the results of preliminary trials are included. The first iteration of a strand mapping program to automate cable strand maps is introduced

  15. SSC 40 mm cable results and 50 mm design discussions

    International Nuclear Information System (INIS)

    Christopherson, D.; Capone, D.; Hannaford, R.; Remsbottom, R.; Jayakumar, R.; Snitchler, G.; Scanlan, R.; Royet, J.

    1990-09-01

    A summary of the cable produced for the 1990 40 mm Dipole Program is presented. The cable design parameters for the 50 mm Dipole Program are discussed, as well as portions of the SSC specification draft. Considerations leading to the final cable configuration and the results of preliminary trials are included. The first iteration of a strand mapping program to automate cable strand maps is introduced. 7 refs., 2 figs., 1 tab

  16. Návrh Rail-to-Rail proudového konvejoru v technologii CMOS

    OpenAIRE

    Hudzik, Martin

    2016-01-01

    Diplomová práca sa zaoberá návrhom rail-to-rail prúdového konvejora druhej generácie v technológii CMOS. Opisuje princípy funkcie jednotlivých generácii prúdových konvejorov a taktiež základný princíp návrhu prúdového konvejora druhej generácie založeného na operačnom zosilňovači. Venuje sa obvodovému riešeniu vstupného rail-to-rail stupňa a koncového stupňa v triede AB. Cieľom tejto práce je navrhnúť, charakterizovať vlastnosti a vytvoriť topológiu prúdového konvejora druhej generácie s rail...

  17. em cristais de Ho:YLF e Er:YLF na região de 3m

    Directory of Open Access Journals (Sweden)

    Fábio Henrique Jagosich

    2006-01-01

    Full Text Available In this work, the deactivation energy transfer mechanisms of 4I13/2 of Er3+ and 5I7 of Ho3+ levels in crystals of LiYF4 (YLF co-doped with Nd3+, Tb3+ and Eu3+ are studied. It was determined the best combination with deactivator ions, capable to maximize the laser gain in the middle of the Ho3+ in 2.9 micrometers (mm and the Er3+ in 2.75 mm operation. The results showed that the Tb3+ and Eu3+ are the best deactivators to the Ho3+ laser operation, while for the Ho3+ laser operation, the best ion deactivator is the Nd3+. The energy transfer characterizations were carried out using the Förster-Dexter method, which consists in the determination of the interaction critic ray, to start from the integral superposition of the absorption cross section spectrum and the involved ions emission.

  18. Shape coexistence in 153Ho

    Science.gov (United States)

    Pramanik, Dibyadyuti; Sarkar, S.; Saha Sarkar, M.; Bisoi, Abhijit; Ray, Sudatta; Dasgupta, Shinjinee; Chakraborty, A.; Krishichayan, Kshetri, Ritesh; Ray, Indrani; Ganguly, S.; Pradhan, M. K.; Ray Basu, M.; Raut, R.; Ganguly, G.; Ghugre, S. S.; Sinha, A. K.; Basu, S. K.; Bhattacharya, S.; Mukherjee, A.; Banerjee, P.; Goswami, A.

    2016-08-01

    The high-spin states in 153Ho have been studied by the La57(20Ne139,6 n ) reaction at a projectile energy of 139 MeV at the Variable Energy Cyclotron Centre (VECC), Kolkata, India, utilizing an earlier campaign of the Indian National Gamma Array (INGA) setup. Data from γ -γ coincidence, directional correlation, and polarization measurements have been analyzed to assign and confirm the spins and parities of the levels. We have suggested a few additions and revisions of the reported level scheme of 153Ho. The RF-γ time difference spectra have been useful to confirm the half-life of an isomer in this nucleus. From the comparison of experimental and theoretical results, it is found that there are definite indications of shape coexistence in this nucleus. The experimental and calculated lifetimes of several isomers have been compared to follow the coexistence and evolution of shape with increasing spin.

  19. Magnetic excitations in Ho2Co17 and Ho2Fe17

    International Nuclear Information System (INIS)

    Clausen, K.N.

    1981-01-01

    The low energy part ( 2 Co 17 and Ho 2 Fe 17 have been measured along the three high symmetry directions at a temperature of 4.2 K, using the inelastic neutron scattering technique. The resulting magnon dispersion relations have been interpreted using linear spin wave theory with a Hamiltonian including single ion crystal field anisotropy and isotropic exchange between spatially well localized spins. The R 2 T 17 structure contains two different Ho sites, with the same point symmetry, and from the spin wave results it was concluded that the crystal field anisotropy of the two Ho sites in both Ho 2 Co 17 and Ho 2 Fe 17 were identical. The deduced crystal field parameters for Ho 2 Fe 17 were slightly larger than for Ho 2 Co 17 , and the parameters were of the same order of magnitude as for pure Ho. For Ho 2 Fe 17 the Fe-Fe exchange was found to be anisotropic, and for both compounds the magnetic ordering temperatures of 1178 K for Ho 2 Co 17 and 335 K for Ho 2 Fe 17 were determined by the strong positive 3d-3d exchange. (Auth.)

  20. Level structure of 154Ho

    Science.gov (United States)

    Moon, Chang-Bum; Komatsubara, Tetsuro; Furuno, Kohei

    2013-10-01

    The excited states of the odd-odd 154Ho nucleus have been studied by using in-beam γ-ray spectroscopy with the 141Pr (16O, 3n) 154Ho reaction at Elab=75 MeV. The beam was provided by the 12UD Pelletron accelerator at the University of Tsukuba. In this work, the complicated decay pattern of low energy transitions just above the T1/2=3.10 min isomer have been established. In addition, a number of new states and γ-ray transitions, especially those associated with energetically favored band termination, have been observed for the first time in 154Ho. A negative collective band and its signature partner built on the 11- level are interpreted as being based on the πh11/2⊗νi13/2 configuration. A positive band built on the 10+ level is based on the πh11/2⊗νh9/2 configuration while another positive band built on the 9+ level is being associated with the πh11/2⊗νf7/2 configuration. An energetically favored level Jπ=19- can be interpreted as being attributed to the πh11/2⊗νi13/2 configuration coupled to the 8+ state in neighboring core 152Dy, namely, a four-quasiparticle alignment based on the [πh11/2νi13/2]11-⊗[ν(h9/2f7/2)]8- configuration. Another energetically favored state at Jπ=27- is assigned the six-quasiparticle [π(h11/2)3]27/2-⊗[ν(f7/2h9/2i13/2)]27/2- configuration.

  1. AN ELISA ASSAY FOR HEME OXYGENASE (HO-1)

    Science.gov (United States)

    An ELISA assay for heme oxygenase (HO-l ) Abstract A double antibody capture ELISA for the HO-l protein has been developed to separately quantitate HO-I protein. The use of 2.5% NP40 detergent greatly assists in freeing HO-l protein from membranes and/or other cel...

  2. Beta dosimetry in intraperitoneal administration of 166Ho-chitosan complex

    International Nuclear Information System (INIS)

    Kim, E. H.; Lim, S. M.; Park, K. B.

    1998-01-01

    Intraperitoneal administration of radioisotopes is suggested to treat the metastatic ovarian cancer in the peritoneal cavity. Administering beta-emitting radioisotopes into the peritoneal cavity allows the maximum energy delivery to the cancerous cells of the peritoneal wall surface while sparing the normal cells located in deep site of the peritoneal wall. In this study, dose estimates of the peritoneal wall are provided to be used for prescribing the amount of 166 Ho-chitosan complex administered. The 166 Ho-chitosan complex diffused in the peritoneal fluid may attach to the peritoneal wall surface. The attachment fraction of 166 Ho-chitosan complex to the peritoneal wall surface is obtained by simulating the ascites with Fischer rats. Both volume source in the peritoneal fluid and the surface source over the peritoneal wall surface are counted for the contribution to the peritoneal wall dose. The Monte Carlo code EGS4 is used to simulate the energy transfer of the beta particles emitted from 166 Ho. A plane geometrical model of semi-infinite volume describes the peritoneal cavity and the peritoneal wall. A semi-infinite plane of 10 μm in thickness at every 1 mm of depth in the peritoneal wall is taken as the target in dose estimation. Greater than 98 percents of attachment fraction has been observed from the experiments with Fischer rats. Given 1.3 μCi/cm 2 and 2.4 μCi/ml of uniform activity density, absorbed dose is 123 Gy, 8.59 Gy, 3.00 Gy, 1.03 Gy, and 327 Gy at 0 mm, 1 mm, 2 mm, 3 mm, and 4 mm in depth to the peritoneal wall, respectively

  3. Reaction rate constant of HO2+O3 measured by detecting HO2 from photofragment fluorescence

    Science.gov (United States)

    Manzanares, E. R.; Suto, Masako; Lee, Long C.; Coffey, Dewitt, Jr.

    1986-01-01

    A room-temperature discharge-flow system investigation of the rate constant for the reaction 'HO2 + O3 yields OH + 2O2' has detected HO2 through the OH(A-X) fluorescence produced by photodissociative excitation of HO2 at 147 nm. A reaction rate constant of 1.9 + or - 0.3 x 10 to the -15th cu cm/molecule per sec is obtained from first-order decay of HO2 in excess O3; this agrees well with published data.

  4. Návrh týmového motivačního programu ve firmě FlatEarth

    OpenAIRE

    Lukaniaková, Nina

    2010-01-01

    Diplomová práca sa zameriava na vytvorenie návrhu motivačného program v spoločnosti FlatEarth. Návrh tohoto programu sa odvíja od výsledkov výskumu uskutočneného v športových teamoch a medzi bývalými zamestnancami spoločnosti FlatEarth. The diploma thesis concentrates on the presentation of motivational programme in the company of our choice- FlatEarth. The suggestion of the motivational programme is based on the results from research conducted in the sport teams and among previous employe...

  5. Estimation of human absorbed dose for (166)Ho-PAM: comparison with (166)Ho-DOTMP and (166)Ho-TTHMP.

    Science.gov (United States)

    Vaez-Tehrani, Mahdokht; Zolghadri, Samaneh; Yousefnia, Hassan; Afarideh, Hossein

    2016-10-01

    In this study, the human absorbed dose of holmium-166 ((166)Ho)-pamidronate (PAM) as a potential agent for the management of multiple myeloma was estimated. (166)Ho-PAM complex was prepared at optimized conditions and injected into the rats. The equivalent and effective absorbed doses to human organs after injection of the complex were estimated by radiation-absorbed dose assessment resource and methods proposed by Sparks et al based on rat data. The red marrow to other organ absorbed dose ratios were compared with these data for (166)Ho-DOTMP, as the only clinically used (166)Ho bone marrow ablative agent, and (166)Ho-TTHMP. The highest absorbed dose amounts are observed in the bone surface and bone marrow with 1.11 and 0.903 mGy MBq(-1), respectively. Most other organs would receive approximately insignificant absorbed dose. While (166)Ho-PAM demonstrated a higher red marrow to total body absorbed dose ratio than (166)Ho-1,4,7,10-tetraazacyclo dodecane-1,4,7,10 tetra ethylene phosphonic acid (DOTMP) and (166)Ho-triethylene tetramine hexa (methylene phosphonic acid) (TTHMP), the red marrow to most organ absorbed dose ratios for (166)Ho-TTHMP and (166)Ho-PAM are much higher than the ratios for (166)Ho-DOTMP. The result showed that (166)Ho-PAM has significant characteristics than (166)Ho-DOTMP and therefore, this complex can be considered as a good agent for bone marrow ablative therapy. In this work, two separate points have been investigated: (1) human absorbed dose of (166)Ho-PAM, as a potential bone marrow ablative agent, has been estimated; and (2) the complex has been compared with (166)Ho-DOTMP, as the only clinically used bone marrow ablative radiopharmaceutical, showing significant characteristics.

  6. Conversion of homothallic yeast to heterothallism trough HO gene disruption

    CSIR Research Space (South Africa)

    Van Zyl, WH

    1993-04-01

    Full Text Available A simple method was developed for the conversion of homothallic Saccharomyces cerevisiae yeaststrains to heterothallism through HO gene disruption. An integrative ho:: neo disrupted allele was constructed by cloning a dominant selectable marker...

  7. Efficient High Power Ho,Tm:GdVO4 Laser

    International Nuclear Information System (INIS)

    Wang Yue-Zhu; Zhu Guo-Li; Ju You-Lun; Yao Bao-Quan

    2011-01-01

    We report a 22.3 W cw diode-pumped cryogenic Ho(0.5at.%),Tm(at.5%):GdVO 4 laser at a wavelength of 2.05 μm. It is pumped by two fiber-coupled laser diodes with a fiber core diameter of 0.4 mm, both of which provide 42 W pump power near 802 nm. A cw output power of 22.3 W was obtained at the pump power of 51.0 W, corresponding to an optical-to-optical conversion efficiency of 43.7% when the ratio of the pump beam to oscillating laser beam in the crystal was ∼1.33:1. The M 2 factor was found to be 2.0 under an output power of 16.5 W. (fundamental areas of phenomenology(including applications))

  8. Measurement of thermal neutron cross-section and resonance integral for the 165Ho(n,γ) 166gHo reaction using electron linac-based neutron source

    Science.gov (United States)

    Nguyen, Van Do; Pham, Duc Khue; Kim, Tien Thanh; Kim, Guinyun; Lee, Manwoo; Kim, Kyung Sook; Kang, Heung-Sik; Cho, Moo-Hyun; Ko, In Soo; Namkung, Won

    2011-01-01

    The thermal neutron cross-section and the resonance integral of the 165Ho(n,γ) 166gHo reaction have been measured by the activation method using a 197Au(n,γ) 198Au monitor reaction as a single comparator. The high-purity natural Ho and Au foils with and without a cadmium shield case of 0.5 mm thickness were irradiated in a neutron field of the Pohang neutron facility. The induced activities in the activated foils were measured with a calibrated p-type high-purity Ge detector. The correction factors for the γ-ray attenuation ( Fg), the thermal neutron self-shielding ( Gth), the resonance neutron self-shielding ( Gepi) effects, and the epithermal neutron spectrum shape factor ( α) were taken into account. The thermal neutron cross-section for the 165Ho(n,γ) 166gHo reaction has been determined to be 59.7 ± 2.5 barn, relative to the reference value of 98.65 ± 0.09 barn for the 197Au(n,γ) 198Au reaction. By assuming the cadmium cut-off energy of 0.55 eV, the resonance integral for the 165Ho(n,γ) 166gHo reaction is 671 ± 47 barn, which is determined relative to the reference value of 1550 ± 28 barn for the 197Au(n,γ) 198Au reaction. The present results are, in general, good agreement with most of the previously reported data within uncertainty limits.

  9. Novostavba rodinného domu

    OpenAIRE

    Manduch, Dávid

    2017-01-01

    Jedná sa o samostatne stojaci, dvojpodlažný, nepodpivničený rodinný dom zastrešený plochou vegetačnou strechou v obci Šalgovce. Súčasťou rodinného domu sú dve drevené terasy. Vstupná terasa sa nachádza pred hlavným vstupom do objektu a terasa pre relax je prístupná z obytnej miestnosti s kuchynským kútom. Z tejto terasy je priamy prístup do záhrady. Hlavný stavebný materiál rodinného domu sú stenové panely EcoCocon - kombinácia dreveného rámu a slamenej výplne Garáž je samostatne stojaci jedn...

  10. Dosimetric intercomparison of permanent Ho-166 seed's implants and HDR Ir-192 brachytherapy in breast cancer.

    Science.gov (United States)

    de Campos, Tarcisio Passos Ribeiro; Nogueira, Luciana Batista; Trindade, Bruno; Cuperschmid, Ethel Mizrahy

    2016-01-01

    To provide a comparative dosimetric analysis of permanent implants of Ho(166)-seeds and temporary HDR Ir(192)-brachytherapy through computational simulation. Brachytherapy with Ir(192)-HDR or LDR based on temporary wires or permanent radioactive seed implants can be used as dose reinforcement for breast radiation therapy. Permanent breast implants have not been a practical clinical routine; although, I(125) and Pd(103)-seeds have already been reported. Biodegradable Ho(166)-ceramic-seeds have been addressed recently. Simulations of implants of nine Ho(166)-seeds and equivalent with HDR Ir(192)-brachytherapy were elaborated in MCNP5, shaped in a computational multivoxel simulator which reproduced a female thorax phantom. Spatial dose rate distributions and dose-volume histograms were generated. Protocol's analysis involving exposure time, seed's activities and dose were performed. Permanent Ho(166)-seed implants presented a maximum dose rate per unit of contained activity (MDR) of 1.1601 μGy h(-1) Bq(-1); and, a normalized MDR in standard points (8 mm, equidistant to 03-seeds - SP1, 10 mm - SP2) of 1.0% (SP1) and 0.5% (SP2), respectively. Ir(192)-brachytherapy presented MDR of 4.3945 × 10(-3) μGy h(-1) Bq(-1); and, 30% (SP1), and 20% (SP2). Therefore, seed's implant activities of 333 MBq (Ho(166)) and 259 GBq (Ir(192)) produced prescribed doses of 58 Gy (SP1; 5d) and 56 Gy (SP1, 5 fractions, 6 min), respectively. Breast Ho(166)-implants of 37-111 MBq are attractive due to the high dose rate near 6-10 mm from seeds, equivalent to Ir(192)-brachytherapy of 259 GBq (3 fractions, 6 min) providing similar dose in standard points at a week; however, with spatial dose distribution better confined. The seed positioning can be adjusted for controlling the breast tumor, in stages I and II, in flat and deep tumors, without any breast volumetric limitation.

  11. Lanthanide recognition: A Ho3+ potentiometric membrane sensor as a probe for determination of terazosin

    International Nuclear Information System (INIS)

    Ganjali, Mohammad Reza; Shams, Haniyeh; Faridbod, Farnoush; Hajiaghababaei, Leila; Norouzi, Parviz

    2009-01-01

    In this study, complexation of N'-(1-pyridin-2-ylmethylene)-2-furohydrazide (NFH) with some metal ions was investigated by conductometry and spectroscopy. Then, a Ho 3+ potentiometric membrane sensor was prepared based on the highly selective complexation between this ionophore and Ho 3+ . These new ionophores are more selective than the previously reported ones. In this work, for the first time, the proposed sensor was applied in indirect determination of the terazocine in its pharmaceutical formulation. The interest in constructing lanthanide sensors arises because they have similar ionic radii to calcium, but a higher charge density, which allows them to be used as probes to find the interactions between Ca 2+ and biologically important molecules.

  12. Výpočet aerodynamiky závodního automobilu

    OpenAIRE

    Vančura, Jan

    2008-01-01

    Diplomové práce je zaměřena na výpočty aerodynamických charakteristik závodního automobilu. Popisuje metodu sestavení CFD modelu s využitím 3D scanneru ATOS a prostředí softwaru Pro Engineer. V průběhu vytváření této práce byly zjištěny vlivy přídavných aerodynamických prvků závodního automobilu na výsledné zatížení náprav. The main subject of this diploma thesis is computation of race car aerodynamics. It describes composition method of CFD model with utilization of 3D scanner ATOS and CA...

  13. Spin Waves in Ho2Co17

    DEFF Research Database (Denmark)

    Clausen, Kurt Nørgaard; Lebech, Bente

    1980-01-01

    Spin wave excitations in a single crystal of Ho2Co17 have been studied at 4.8 and 78 K. The results are discussed in terms of a linear spin wave model. At 78 K both ground state and excited state spin waves are observed.......Spin wave excitations in a single crystal of Ho2Co17 have been studied at 4.8 and 78 K. The results are discussed in terms of a linear spin wave model. At 78 K both ground state and excited state spin waves are observed....

  14. Sticking of HO2 on fatty acids aggregates

    Science.gov (United States)

    Vardanega, Delphine; Briquez, Stéphane; Duflot, Denis; Monnerville, Maurice; Toubin, Céline

    2015-04-01

    Models of atmospheric chemistry are widely used to perform projections of future changes in the chemical composition of the global troposphere, including changes in climate related greenhouse gases and aerosol particles. However, large uncertainties are still associated with the chemistry implemented in these models, which in turn can lead to inaccurate long-term predictions. The proposed work seeks to improve our understanding of the oxidative capacity of the atmosphere, which drives the lifetime of trace gases, and therefore atmospheric composition. Recent measurements [1] of free radicals made in forested environments characterized by low levels of nitrogen oxides (NOx = NO and NO2) indicate that current models of atmospheric chemistry tend to overestimate the concentration of peroxy radicals (HO2 and RO2). An overestimation of peroxy radicals is an important issue since these radicals are the main precursors of the hydroxyl radical (OH), the most important atmospheric oxidant during daytime. This issue could lead to a significant overestimation of the oxidative capacity of the global atmosphere since more than 86% of the Earth surface is covered by forests, oceans, and polar regions. An analysis of this dataset indicates that the missing sink could be due to an underestimation of the rates of RO2+HO2 reactions, and/or the uptake of peroxy radicals onto aerosol particles. A thorough evaluation of scientific studies published in the literature shows that there is a lack of kinetic and mechanistic data to correctly assess the contribution of these two loss pathways of peroxy radicals in low NOx environments. Classical molecular dynamics simulations, using the Gromacs package [2], are performed to study the interaction of HO2 with organic (carboxylic acid) aerosols. The effect of the presence of water molecules on the surface are also be investigated. These calculations provide theoretical values for observable quantities such as uptake and mass accommodation

  15. Saigon-Ho Chi Minh City

    NARCIS (Netherlands)

    Nguyen, T.B.; Samsura, D.A.A.; Krabben, E. van der; Le, A.D.; Le, A.-D.

    2016-01-01

    Ho Chi Minh City (HCMC) has existed for over three centuries and has developed into the financial capital and most important economic hub of Vietnam. This profile outlines the history of HCMC's development and its impact on current conditions and physical structure of the city. The paper analyzes

  16. Heterogeneous photochemistry of imidazole-2-carboxaldehyde: HO2 radical formation and aerosol growth

    Directory of Open Access Journals (Sweden)

    L. González Palacios

    2016-09-01

    Full Text Available The multiphase chemistry of glyoxal is a source of secondary organic aerosol (SOA, including its light-absorbing product imidazole-2-carboxaldehyde (IC. IC is a photosensitizer that can contribute to additional aerosol ageing and growth when its excited triplet state oxidizes hydrocarbons (reactive uptake via H-transfer chemistry. We have conducted a series of photochemical coated-wall flow tube (CWFT experiments using films of IC and citric acid (CA, an organic proxy and H donor in the condensed phase. The formation rate of gas-phase HO2 radicals (PHO2 was measured indirectly by converting gas-phase NO into NO2. We report on experiments that relied on measurements of NO2 formation, NO loss and HONO formation. PHO2 was found to be a linear function of (1 the [IC]  ×  [CA] concentration product and (2 the photon actinic flux. Additionally, (3 a more complex function of relative humidity (25 %  <  RH  <  63 % and of (4 the O2 ∕ N2 ratio (15 %  <  O2 ∕ N2  <  56 % was observed, most likely indicating competing effects of dilution, HO2 mobility and losses in the film. The maximum PHO2 was observed at 25–55 % RH and at ambient O2 ∕ N2. The HO2 radicals form in the condensed phase when excited IC triplet states are reduced by H transfer from a donor, CA in our system, and subsequently react with O2 to regenerate IC, leading to a catalytic cycle. OH does not appear to be formed as a primary product but is produced from the reaction of NO with HO2 in the gas phase. Further, seed aerosols containing IC and ammonium sulfate were exposed to gas-phase limonene and NOx in aerosol flow tube experiments, confirming significant PHO2 from aerosol surfaces. Our results indicate a potentially relevant contribution of triplet state photochemistry for gas-phase HO2 production, aerosol growth and ageing in the atmosphere.

  17. Application of MM wave therapy in radiology

    Energy Technology Data Exchange (ETDEWEB)

    Avakian, R.S. [Inst. of Radio Physics & Electronics, Ashtarack (Argentina); Gasparyan, L.V. [Republican Medical Centre Armenia, Yerevan (Argentina)

    1995-12-31

    The authors studied the effects of MM wave electromagnetic radiation influence on patients, affected by X-ray radiation during the reparation works after Chernobyl nuclear power plant exposure. They compared results of treatment of two groups of patients: (1) control group patients received only basis therapy; (2) testing group, 10 patients received basis therapy and MM wave influence. The authors used the wide band noise generator `Artsakh - 2` for local irradiation on the acupuncture points. Their data proved that low intensity MM waves have immunocorrective, antioxidant effects, and MM wave therapy is a perspective method for treatment of patients with radiological pathology.

  18. Strømmålinger ved Sæby Udløbsledning

    DEFF Research Database (Denmark)

    Larsen, Torben

    Med henblik på at vurdere tidevandsstrømningens amplitude i det kystnære område ud for Sæby har man i ca. 14 dage fra 25.5.81 til 11.6.81 haft udlagt en Aanderraa RCM 4 strømmåler ca. 1 m under overfladen på ca. 4 m vanddybde. Måleren la ca. 900 m fra land i en linje, som var en forlængelse af...

  19. Single crystal growth and anisotropic magnetic properties of HoAl2Ge2

    Science.gov (United States)

    Matin, Md.; Mondal, Rajib; Thamizhavel, A.; Provino, A.; Manfrinetti, P.; Dhar, S. K.

    2018-05-01

    We have grown a single crystal of HoAl2Ge2, which crystallizes in the hexagonal CaAl2Si2 type structure with Ho ions in the trigonal coordination in the ab plane. The data obtained from the bulk measurement techniques of magnetization, heat capacity and transport reveal that HoAl2Ge2 orders antiferromagnetically at TN ˜6.5 K. The susceptibility below TN and isothermal magnetization at 2 K indicate the ab plane as the easy plane of magnetization. Heat capacity data reveal a prominent Schottky anomaly with a broad peak centered around 25 K, suggesting a relatively low crystal electric field (CEF) splitting. The electrical resistivity reveals the occurrence of a superzone gap below TN. The point charge model of the CEF is applied to the magnetization and the heat capacity data. While a good fit to the paramagnetic susceptibility is obtained, the CEF parameters do not provide a satisfactory fit to the isothermal magnetization at 2 K and the Schottky anomaly.

  20. An inhibitory effect of extracellular Ca2+ on Ca2+-dependent exocytosis.

    Directory of Open Access Journals (Sweden)

    Wei Xiong

    Full Text Available AIM: Neurotransmitter release is elicited by an elevation of intracellular Ca(2+ concentration ([Ca(2+](i. The action potential triggers Ca(2+ influx through Ca(2+ channels which causes local changes of [Ca(2+](i for vesicle release. However, any direct role of extracellular Ca(2+ (besides Ca(2+ influx on Ca(2+-dependent exocytosis remains elusive. Here we set out to investigate this possibility on rat dorsal root ganglion (DRG neurons and chromaffin cells, widely used models for studying vesicle exocytosis. RESULTS: Using photolysis of caged Ca(2+ and caffeine-induced release of stored Ca(2+, we found that extracellular Ca(2+ inhibited exocytosis following moderate [Ca(2+](i rises (2-3 µM. The IC(50 for extracellular Ca(2+ inhibition of exocytosis (ECIE was 1.38 mM and a physiological reduction (∼30% of extracellular Ca(2+ concentration ([Ca(2+](o significantly increased the evoked exocytosis. At the single vesicle level, quantal size and release frequency were also altered by physiological [Ca(2+](o. The calcimimetics Mg(2+, Cd(2+, G418, and neomycin all inhibited exocytosis. The extracellular Ca(2+-sensing receptor (CaSR was not involved because specific drugs and knockdown of CaSR in DRG neurons did not affect ECIE. CONCLUSION/SIGNIFICANCE: As an extension of the classic Ca(2+ hypothesis of synaptic release, physiological levels of extracellular Ca(2+ play dual roles in evoked exocytosis by providing a source of Ca(2+ influx, and by directly regulating quantal size and release probability in neuronal cells.

  1. Correlating states across isomers in 152Ho isotope

    International Nuclear Information System (INIS)

    Pramanik, Dibyadyuti; Dey, G.; Sarkar, S.; Bisoi, A.; Ray, S.; Kshetri, R.; Ray, I.; Pradhan, M.K.; Goswami, A.; Banerjee, P.; Mukherjee, A.; Bhattacharya, S.; Saha Sarkar, M.; Chakraborty, A.; Krishichayan; Ganguly, S.; Ray Basu, M.; Ganguly, G.; Raut, R.; Ghugre, S.S.; Sinha, A.K.; Basu, S.K.

    2011-01-01

    The odd-odd 152 Ho (N = 85) is a very interesting candidate for investigation of interplay of single - particle oblate states and prolate collective states, because it is situated between the N=82 shell closure and the strongly collective N > 87 region. It has been shown that there is a possibility of shape coexistence even at lower spins in 153 Ho. The structural evolution of Ho isotopes from A = 151 to 154 has also been studied. The features observed have been interpreted theoretically using shell model as well as Total Routhian surface calculations. Results have been combined with that for 153 Ho to study the evolution of structural features in these Ho isotopes with increasing neutron numbers and increasing spin. In the present work, experimental data on 152 Ho have been analysed to connect the three groups of transitions and confirm the possibility of a fourth isomer in the excitation spectrum

  2. MM Algorithms for Geometric and Signomial Programming.

    Science.gov (United States)

    Lange, Kenneth; Zhou, Hua

    2014-02-01

    This paper derives new algorithms for signomial programming, a generalization of geometric programming. The algorithms are based on a generic principle for optimization called the MM algorithm. In this setting, one can apply the geometric-arithmetic mean inequality and a supporting hyperplane inequality to create a surrogate function with parameters separated. Thus, unconstrained signomial programming reduces to a sequence of one-dimensional minimization problems. Simple examples demonstrate that the MM algorithm derived can converge to a boundary point or to one point of a continuum of minimum points. Conditions under which the minimum point is unique or occurs in the interior of parameter space are proved for geometric programming. Convergence to an interior point occurs at a linear rate. Finally, the MM framework easily accommodates equality and inequality constraints of signomial type. For the most important special case, constrained quadratic programming, the MM algorithm involves very simple updates.

  3. Magnetometer Data recovered from 35mm film

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The L57 CDMP recovery project takes magnetometer data on 35mm film stored at the archive's climate controlled warehouse and digitizes them.

  4. High spin levels in 151Ho

    International Nuclear Information System (INIS)

    Gizon, J.; Gizon, A.; Andre, S.; Genevey, J.; Jastrzebski, J.; Kossakowski, R.; Moszinski, M.; Preibisz, Z.

    1981-02-01

    We report here on the first study of the level structure of 151 Ho. High spin levels in 151 Ho have been populated in the 141 Pr + 16 O and 144 Sm + 12 C reactions. The level structure has been established up to 6.6 MeV energy and the spins and particles determined up to 49/2 - . Most of the proposed level configurations can be explained by the coupling of hsub(11/2) protons to fsub(7/2) and/or hsub(9/2) neutrons. An isomer with 14 +- 3 ns half-life and a delayed gamma multiplicity equal to 17 +- 2 has been found. Its spin is larger than 57/2 h units

  5. Systematic Quantum Mechanical Region Determination in QM/MM Simulation.

    Science.gov (United States)

    Karelina, Maria; Kulik, Heather J

    2017-02-14

    Hybrid quantum mechanical-molecular mechanical (QM/MM) simulations are widely used in enzyme simulation. Over ten convergence studies of QM/MM methods have revealed over the past several years that key energetic and structural properties approach asymptotic limits with only very large (ca. 500-1000 atom) QM regions. This slow convergence has been observed to be due in part to significant charge transfer between the core active site and the surrounding protein environment, which cannot be addressed by improvement of MM force fields or the embedding method employed within QM/MM. Given this slow convergence, it becomes essential to identify strategies for the most atom-economical determination of optimal QM regions and to gain insight into the crucial interactions captured only in large QM regions. Here, we extend and develop two methods for quantitative determination of QM regions. First, in the charge shift analysis (CSA) method, we probe the reorganization of electron density when core active site residues are removed completely, as determined by large-QM region QM/MM calculations. Second, we introduce the highly parallelizable Fukui shift analysis (FSA), which identifies how core/substrate frontier states are altered by the presence of an additional QM residue in smaller initial QM regions. We demonstrate that the FSA and CSA approaches are complementary and consistent on three test case enzymes: catechol O-methyltransferase, cytochrome P450cam, and hen eggwhite lysozyme. We also introduce validation strategies and test the sensitivities of the two methods to geometric structure, basis set size, and electronic structure methodology. Both methods represent promising approaches for the systematic, unbiased determination of quantum mechanical effects in enzymes and large systems that necessitate multiscale modeling.

  6. Antiperovskite nitridophosphate oxide Ho{sub 3}[PN{sub 4}]O by high-pressure metathesis

    Energy Technology Data Exchange (ETDEWEB)

    Kloss, Simon D.; Weidmann, Niels; Schnick, Wolfgang [Department of Chemistry, University of Munich (LMU), Butenandtstrasse 5-13, 81377, Munich (Germany)

    2017-04-03

    Rare-earth nitridophosphates are a recently discovered class of materials, which are accessible by high-pressure metathesis. Antiperovskite-type Ho{sub 3}[PN{sub 4}]O was synthesized from HoF{sub 3}, LiPN{sub 2}, Li{sub 3}N, and Li{sub 2}O at 5 GPa and ca. 1025 C by this method and the multianvil technique. Ho{sub 3}[PN{sub 4}]O contains rarely observed isolated PN{sub 4} tetrahedra and can be derived by the hierarchical substitution of the ABX{sub 3} perovskite, in which Ho occupies the X positions, O occupies the B position, and the PN{sub 4} tetrahedra occupy the A position. The structure was refined on the basis of powder diffraction data [I4/mcm, a = 6.36112(3), c = 10.5571(1) Aa, Z = 4, R{sub wp} = 0.04, R{sub Bragg} = 0.01, χ{sup 2} = 2.275] starting from the structural model of isotypic Gd{sub 3}[SiN{sub 3}O]O. To characterize Ho{sub 3}[PN{sub 4}]O, elemental analyses were performed through energy-dispersive X-ray spectroscopy (EDX) and inductively coupled plasma optical emission spectroscopy (ICP-OES). Ho{sub 3}[PN{sub 4}]O is paramagnetic down to low temperatures with μ{sub eff} = 10.43(1) μ{sub B} and a Curie temperature (Θ) of 0.11(4) K. It shows the optical characteristics of Ho{sup 3+} ions and vibrations corresponding to isolated PN{sub 4} tetrahedra. On the basis of DFT calculations [generalized gradient approximation (GGA)], Ho{sub 3}[PN{sub 4}]O has an indirect band gap of 1.87 eV. We demonstrate the versatility of high-pressure metathesis by attaining the low end of the P/N atomic ratio κ = 1/4. This confirms the previous assumption that rare-earth nitridophosphates with κ = 1/2 to 1/4 are feasible by this method. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  7. Epigallocatechin-3-gallate (EGCG) protects skin cells from ionizing radiation via heme oxygenase-1 (HO-1) overexpression

    International Nuclear Information System (INIS)

    Zhu Wei; Xu Jing; Ge Yangyang

    2014-01-01

    Epigallocatechin-3-gallate (EGCG), the major polyphenolic constituent of green tea, is a potent antioxidant and free radical scavenger that may have therapeutic applications for the treatment of many disorders. Radiation therapy is widely used for the treatment of various types of cancers; however, radiation-induced skin injury remains a serious concern. EGCG has not yet been reported as protecting skin cells against ionizing radiation. In the present study, we investigated whether EGCG confers cytoprotection against ionizing radiation. We found that, compared with the control, pretreatment with EGCG significantly enhanced the viability of human skin cells that were irradiated with X-rays, and decreased apoptosis induced by X-ray irradiation. Mito-Tracker assay showed that EGCG suppressed the damage to mitochondria induced by ionizing radiation via upregulation of SOD2. Reactive oxygen species (ROS) in HaCaT cells were significantly reduced when pretreated with EGCG before irradiation. Radiation-induced γH2AX foci, which are representative of DNA double-strand breaks, were decreased by pretreatment with EGCG. Furthermore, EGCG induced the expression of the cytoprotective molecule heme oxygenase-1 (HO-1) in a dose-dependent manner via transcriptional activation. HO-1 knockdown or treatment with the HO-1 inhibitor tin protoporphyrin (SnPPIX) reversed the protective role of EGCG, indicating an important role for HO-1. These results suggest that EGCG offers a new strategy for protecting skin against ionizing radiation. (author)

  8. Использование теории поколений Хоува и Штрауса при разработке маркетинговых программ предприятий сегмента HoReCa

    OpenAIRE

    ТИХОНЮК НАТАЛЬЯ ЕВГЕНЬЕВНА

    2015-01-01

    В статье рассмотрены принципиальные аспекты разработки маркетинговых программ с использованием теории поколений Хоува и Штрауса. Предложен вариант маркетинговой коммуникационной программы для предприятия HoReCa для различных поколений посетителей.

  9. The quantitative analysis of 163Ho source by PIXE

    International Nuclear Information System (INIS)

    Sera, K.; Ishii, K.; Fujioka, M.; Izawa, G.; Omori, T.

    1984-01-01

    We have been studying the electron-capture in 163 Ho as a method for determining the mass of electron neutrino. The 163 Ho sources were produced with the 164 Dy(p,2n) reaction by means of a method of internal irradiation 2 ). We applied the PIXE method to determine the total number of 163 Ho atoms in the source. Proton beams of 3 MeV and a method of ''external standard'' were employed for nondestructive analysis of the 163 Ho source as well as an additional method of ''internal standard''. (author)

  10. Growth and characterization of Yb:Ho:YAG single crystal fiber

    Science.gov (United States)

    Yang, Yilun; Ye, Linhua; Bao, Renjie; Li, Shanming; Zhang, Peixiong; Xu, Min; Hang, Yin

    2018-06-01

    High quality Yb and Ho co-doped Y3Al5O12 single crystal fibers have been successfully grown by the laser heated pedestal growth method of up to 124 mm in length and 450 μm in diameter for the first time. The results of inductively coupled plasma-atomic emission spectrometry analysis, X-ray diffraction and Raman spectroscopy reveal that the lattice structure and doping concentrations of the SCF are the same as that of the bulk. Scanning electron microscopy microphotographs shows that the fibers only have minor diameter fluctuations within 0.5%.

  11. Microeconomics of 300-mm process module control

    Science.gov (United States)

    Monahan, Kevin M.; Chatterjee, Arun K.; Falessi, Georges; Levy, Ady; Stoller, Meryl D.

    2001-08-01

    Simple microeconomic models that directly link metrology, yield, and profitability are rare or non-existent. In this work, we validate and apply such a model. Using a small number of input parameters, we explain current yield management practices in 200 mm factories. The model is then used to extrapolate requirements for 300 mm factories, including the impact of simultaneous technology transitions to 130nm lithography and integrated metrology. To support our conclusions, we use examples relevant to factory-wide photo module control.

  12. PENGENDALIAN DALAM PENERBITAN IZIN GANGGUAN (HO

    Directory of Open Access Journals (Sweden)

    Pebriana Marlinda

    2017-04-01

    Full Text Available Abstrak :            Penelitian tentang pengendalian dalam penerbitan izin gangguan (HO di Kecamatan Margahayu Kabupaten Bandung menjelaskan tentang tahap-tahap pengendalian yang dilakukan oleh aparat Kecamatan Margahayu. Pengendalian dilakukan untuk memastikan agar penerbitan izin gangguan (HO berjalan dengan efektif. Namun, masih ada pelaku usaha yang belum memiliki surat izin gangguan (HO ataupun pelaku usaha yang sudah memiliki surat izin gangguan (HO akan tetapi kegiatan usahanya merugkan orang lain seperti sampah yang berserakan, polusi udara, polusi suara, dan lain-lain.                            Metode penelitian yang digunakan adalah metode penelitian deduktif kualitatif dengan teknik pengumpulan data melalui studi kepustakaan dan studi lapangan yang meliputi observasi dan wawancara mendalam. Adapun penentuan informan dalam penelitian ini dipilih berdasarkan pertimbangan-pertimbangan dengan pihak-pihak yang terkait dalam pengendalian. Kemudian data yang diperoleh dari hasil wawancara dipaparkan dengan langkah-langkah yang meliputi: reduksi data, penyajian data, menarik kesimpulan/verifikasi. Teori yang digunakan penulis dalam penelitian ini adalah teori dari Stephen P. Robbins tentang tahap-tahap pengendalian yaitu: mengukur kinerja aktual, membandingkan kinerja aktual dengan standar, dan mengambil tindakan manajerial.                            Kesimpulan dari hasil penelitian ini adalah pengendalian yang dilakukan olehaparat Kecamatan Margahayu telah melalui tahap-tahap pengendalian yaitu: mengukur kinerja aktual, membandingkan kinerja aktual dengan standar, dan mengambil tindakan manajerial. Namun perlu dilakukan penguatan di setiap tahap pengendalian terutama pada tahap mengukur kinerja aktual dan pada tahap mengambil tindakan manajerial                            Penelitian tentang pengendalian dalam penerbitan izin gangguan (HO di Kecamatan

  13. Potential and profile experiments in MM-4

    International Nuclear Information System (INIS)

    Tian Zhongyu; Ming Linzhou; Feng Xiaozhen; Feng Chuntang; Yin Youjun; Liu Yuhua; Wang Jihai

    1988-01-01

    Experimental results in MM-4 are presented. These results show that there were double potential wells and double ion temperatures in the plasma. The mechanism giving rise to such potential profiles can be attributed to the Stormer region in the cusp system and the different operation regimes of the electron gun used. The measured plasma potential was about - 200 - 300V

  14. EGR-1 regulates Ho-1 expression induced by cigarette smoke

    International Nuclear Information System (INIS)

    Chen, Huaqun; Wang, Lijuan; Gong, Tao; Yu, Yang; Zhu, Chunhua; Li, Fen; Wang, Li; Li, Chaojun

    2010-01-01

    As an anti-oxidant molecule, heme oxygenase-1 (HO-1) has been implicated in the protection of lung injury by cigarette smoke (CS). The mechanisms regulating its expression have not been defined. In this report, the role of early growth response 1 (EGR-1) in the regulation of Ho-1 expression was investigated. In C57BL/6 mice with CS exposure, HO-1 was greatly increased in bronchial epithelial cells and alveolar inflammatory cells. In primary cultured mouse lung fibroblasts and RAW264.7 cells exposed to cigarette smoke water extract (CSE), an increase in HO-1 protein level was detected. In addition, CSE induced HO-1 expression was decreased in Egr-1 deficient mouse embryo fibroblasts (Egr-1 -/- MEFs). Nuclear localization of EGR-1 was examined in mouse lung fibroblasts after exposure to CSE. Luciferase reporter activity assays showed that the enhancer region of the Ho-1 gene containing a proposed EGR-1 binding site was responsible for the induction of HO-1. A higher increase of alveolar mean linear intercept (Lm) was observed in lung tissues, and a larger increase in the number of total cells and monocytes/macrophages from bronchial alveolar lavage fluid was found in CS-exposed mice by loss of function of EGR-1 treatment. In summary, the present data demonstrate that EGR-1 plays a critical role in HO-1 production induced by CS.

  15. Lattice effects in HoVo(3) single crystal

    NARCIS (Netherlands)

    Sikora, M.; Marquina, C.; Ibarra, M. R.; Nugroho, A. A.; Palstra, T. T. M.

    We report the study of lattice effects in the Mott insulator HoVO3 performed by means of linear thermal expansion on a single crystal in the temperature range 10-290 K. The holmium orthovanadate HoVO3 reveals gradual orbital ordering (OO) below T-OO = 200K and orders antiferromagnetically at T-N =

  16. Fer-Ho Anaphora in Catalan: Semantic and Discourse Properties

    Science.gov (United States)

    Busquets, Joan

    2018-01-01

    This paper considers the anaphoric status of the pro-form "fer-ho" (do it) in Catalan [This paper contains some ideas included in Busquets (2005)]. I discuss some anaphoric properties of "fer-ho" as deep anaphora. I also compare these properties to those of other types of anaphora, like VPE and pseudogapping (pg). I show that…

  17. Optical properties of Ho3+-doped NaGd(WO4)2 crystal for laser materials

    International Nuclear Information System (INIS)

    Wang, Hongyan; Li, Jianfu; Jia, Guohua; You, Zhenyu; Yang, Fugui; Wei, Yanping; Wang, Yan; Zhu, Zhaojie; Lu, Xiuai; Tu, Chaoyang

    2007-01-01

    Holmium doped sodium gadolinium tungstate crystals with sizes of about O20 mm x 40 mm were grown successfully by the Czochralski technique along the (0 0 1) orientation. Polarized absorption spectra, fluorescence spectra and fluorescence decay curve of Ho 3+ -doped NaGd(WO 4 ) 2 have been recorded at room temperature. Based on the Judd-Ofelt theory, three intensity parameters were obtained. The spectroscopic parameters of this crystal such as the oscillator strengths, radiative transition probabilities, radiative lifetimes as well as the branching ratios were calculated. The fluorescence lifetime τ f of the 5 S 2 level was measured to be 5 μs

  18. Methane-rich water induces cucumber adventitious rooting through heme oxygenase1/carbon monoxide and Ca(2+) pathways.

    Science.gov (United States)

    Cui, Weiti; Qi, Fang; Zhang, Yihua; Cao, Hong; Zhang, Jing; Wang, Ren; Shen, Wenbiao

    2015-03-01

    Methane-rich water triggered adventitious rooting by regulating heme oxygenase1/carbon monoxide and calcium pathways in cucumber explants. Heme oxygenase1/carbon monoxide (HO1/CO) and calcium (Ca(2+)) were reported as the downstream signals in auxin-induced cucumber adventitious root (AR) formation. Here, we observed that application of methane-rich water (MRW; 80% saturation) obviously induced AR formation in IAA-depleted cucumber explants. To address the universality, we checked adventitious rooting in soybean and mung bean explants, and found that MRW (50 and 10% saturation, respectively) exhibited the similar inducing results. To further determine if the HO1/CO system participated in MRW-induced adventitious rooting, MRW, HO1 inducer hemin, its activity inhibitor zinc protoporphyrin IX (ZnPP), and its catalytic by-products CO, bilirubin, and Fe(2+) were used to detect their effects on cucumber adventitious rooting in IAA-depleted explants. Subsequent results showed that MRW-induced adventitious rooting was blocked by ZnPP and further reversed by 20% saturation CO aqueous solution. However, the other two by-products of HO1, bilirubin and Fe(2+), failed to induce AR formation. Above responses were consistent with the MRW-induced increases of HO1 transcript and corresponding protein level. Further molecular evidence indicted that expression of marker genes, including auxin signaling-related genes and cell cycle regulatory genes, were modulated by MRW alone but blocked by the cotreatment with ZnPP, the latter of which could be significantly rescued by the addition of CO. By using the Ca(2+)-channel blocker and Ca(2+) chelator, the involvement of Ca(2+) pathway in MRW-induced adventitious rooting was also suggested. Together, our results indicate that MRW might serve as a stimulator of adventitious rooting, which was partially mediated by HO1/CO and Ca(2+) pathways.

  19. Ho:YLF pumped HBr laser

    CSIR Research Space (South Africa)

    Botha, LR

    2009-10-01

    Full Text Available , “Optically Pumped Mid-Infrared HBr Laser,” IEEE J. Quantum Electron. 30(10), 2395–2400 (1994). 2. C. S. Kletecka, N. Campbell, C. R. Jones, J. W. Nicolson, and W. Rudolph, “Cascade Lasing of Molecular HBr in the Four Micron Region Pumped by a Nd:YAG laser...-Infrared Coherent Sources, (European Physical Society 2009) Invited Talk Mo3. 5. C. Bollig, H. J. Strauss, M. J. D. Esser, W. Koen, M.Schellhorn, D. Preussler, K. Nyangaza, C. Jacobs, E. H. Bernardi and L. R. Botha, “Compact Fibre-Laser-Pumped Ho:YLF Oscillator...

  20. Activation of the Nrf2/HO-1 Antioxidant Pathway Contributes to the Protective Effects of Lycium Barbarum Polysaccharides in the Rodent Retina after Ischemia-Reperfusion-Induced Damage

    Science.gov (United States)

    Chang, Raymond Chuen-Chung; So, Kwok-Fai; Brecha, Nicholas C.; Pu, Mingliang

    2014-01-01

    Lycium barbarum polysaccharides (LBP), extracts from the wolfberries, are protective to retina after ischemia-reperfusion (I/R). The antioxidant response element (ARE)–mediated antioxidant pathway plays an important role in maintaining the redox status of the retina. Heme oxygenase-1 (HO-1), combined with potent AREs in its promoter, is a highly effective therapeutic target for the protection against neurodegenerative diseases, including I/R-induced retinal damage. The aim of our present study was to investigate whether the protective effect of LBP after I/R damage was mediated via activation of the Nrf2/HO-1-antioxidant pathway in the retina. Retinal I/R was induced by an increase in intraocular pressure to 130 mm Hg for 60 minutes. Prior to the induction of ischemia, rats were orally treated with either vehicle (PBS) or LBP (1 mg/kg) once a day for 1 week. For specific experiments, zinc protoporphyrin (ZnPP, 20 mg/kg), an HO-1 inhibitor, was intraperitoneally administered at 24 h prior to ischemia. The protective effects of LBP were evaluated by quantifying ganglion cell and amacrine cell survival, and by measuring cell apoptosis in the retinal layers. In addition, HO-1 expression was examined using Western blotting and immunofluorescence analyses. Cytosolic and nuclear Nrf2 was measured using immunofluorescent staining. LBP treatment significantly increased Nrf2 nuclear accumulation and HO-1 expression in the retina after I/R injury. Increased apoptosis and a decrease in the number of viable cells were observed in the ganglion cell layer (GCL) and inner nuclear layer (INL) in the I/R retina, which were reversed by LBP treatment. The HO-1 inhibitor, ZnPP, diminished the LBP treatment-induced protective effects in the retina after I/R. Taken together, these results suggested that LBP partially exerted its beneficial neuroprotective effects via the activation of Nrf2 and an increase in HO-1 protein expression. PMID:24400114

  1. Preparation of .sup.166./sup.Ho-Macroaggregates and .sup.166./sup.Ho-Chitosan for the Radiotherapy

    Czech Academy of Sciences Publication Activity Database

    Kropáček, Martin; Melichar, František; Mirzajevová, Marcela

    2002-01-01

    Roč. 29, č. 2 (2002), s. 382 ISSN 1619-7070 R&D Projects: GA MZd NM6828; GA AV ČR KSK4055109 Keywords : Holmium-166 * 166 Ho-macroaggregates * 166 Ho-chitosan Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders

  2. Use of a genetically enhanced, pediocin-producing starter culture, Lactococcus lactis subsp. lactis MM217, to control Listeria monocytogenes in cheddar cheese

    NARCIS (Netherlands)

    Buyong, N; Kok, J; Luchansky, JB

    1998-01-01

    Cheddar cheese was prepared with Lactococcus lactis subsp, lactis MM217, a starter culture which contains pMC117 coding for pediocin PA-1, About 75 liters of pasteurized milk (containing ca, 3.6% fat) was inoculated with strain MM217 (ca, 10(6) CFU per ml) and a mixture of three Listeria

  3. X-ray cine magnification angiography by 0.6 mm focal spot

    International Nuclear Information System (INIS)

    Tanaka, Isao; Wakamatsu, Takashi; Sano, Toshiya

    1983-01-01

    To observe microstructures on the X-ray cinematography by 0.6 mm focal spot, usefulness of enlarged shooting was studied. As a result, even at a focus of 0.6 mm, the enlarged shooting (ca. 1.7-fold) revealed the superior total M.T.F. than that of contact photography. Furthermore, Groedel effect upon magnification was as good as the grid system. In the cardiac catheterization by 0.6 mm focal spot being employed most frequently at present, the enlarged shooting without using grid is a useful method. Thus, it is considered to take up this method as much as possible. (author)

  4. X-ray analytics for 450-mm wafer; Roentgenanalytik fuer 450-mm-Wafer

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2014-09-15

    The introduction of the 450-mm technology in the wafer fabrication and the further reduction of critical dimensions requires improved X-ray analysis methods. Therefor the PTB has concipated a metrology chamber for the characterization of 450-mm wafers, the crucial element of which is a multi-axis patent-pending manipulator.

  5. Strategie Elektronického obchodu firmy

    OpenAIRE

    Gašpar, Petr

    2011-01-01

    Moje bakalářská práce se bude zabývat volbou vhodnou strategie pro vybudování elektronického obchodu maloobchodní firmy. V práci se zaměřím na to jak docílit aby firma rozšířila své působení na trhu a to právě pomocí elektronického obchodu. Dále budu ve své práci taky mapovat současnou situaci problematiky elektronických obchodů. Analyzuji trh, konkurenci a na základě těchto údajů zvolím strategii, aby elektronický obchod prosperoval. V praktické části se potom zaměřím na maloobchodní firmu J...

  6. Ca-site substitution induced a metal-insulator transition in manganite CaMnO3

    International Nuclear Information System (INIS)

    Sousa, D.; Nunes, M.R.; Silveira, C.; Matos, I.; Lopes, A.B.; Melo Jorge, M.E.

    2008-01-01

    A systematic study of the A-site doping in Mn(IV)-rich perovskite manganites Ca 1-x Ho x MnO 3 , over a large homogeneity range (0.1 ≤ x ≤ 0.4), has been performed. A significant increase in the lattice parameters indicated the presence of mixed valence state of Mn: Mn 3+ and Mn 4+ . The substitution of calcium by holmium also induces strong changes in the electrical properties. We found that small Ho concentration produces an important decrease in the electrical resistivity and induces an electrical transition, the temperature corresponding to the metal-insulator transition (T MI ) shifts with the holmium content. This electrical behavior is attributed to the Mn 3+ ions content and a charge order effect

  7. 29 mm Diameter Target Test Report

    Energy Technology Data Exchange (ETDEWEB)

    Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Olivas, Eric Richard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dale, Gregory E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Naranjo, Angela Carol [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Romero, Frank Patrick [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Chemerisov, Sergey [Argonne National Lab. (ANL), Argonne, IL (United States); Gromov, Roman [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-10-23

    After numerous delays, the test of the 29 mm diameter target was conducted on 8/18/2017. The complete target design report, dated 8/15/2016, is reproduced below for completeness. This describes in detail the 10 disk target with varying thickness disks. The report presents and discusses the test results. In brief summary, there appears to have been multiple instrumentation errors. Measured temperatures, pressures and IR camera window temperature measurement are all suspect. All tests were done at 35 MeV, with 171 μA current, or 6 kW of beam power.

  8. Heterogeneous Uptake of HO2 Radicals onto Atmospheric Aerosols

    Science.gov (United States)

    George, I. J.; Matthews, P. S.; Brooks, B.; Goddard, A.; Whalley, L. K.; Baeza-Romero, M. T.; Heard, D. E.

    2011-12-01

    The hydroxyl (OH) and hydroperoxyl (HO2) radicals, together known as HOx, play a vital role in atmospheric chemistry by controlling the oxidative capacity of the troposphere. The atmospheric lifetime and concentrations of many trace reactive species, such as volatile organic compounds (VOCs), are determined by HOx radical levels. Therefore, the ability to accurately predict atmospheric HOx concentrations from a detailed knowledge of their sources and sinks is a very useful diagnostic tool to assess our current understanding of atmospheric chemistry. Several recent field studies have observed significantly lower concentrations of HO2 radicals than predicted using box models, where HO2 loss onto aerosols was suggested as a possible missing sink [1, 2]. However, the mechanism on HO2 uptake onto aerosols and its impact on ambient HOx levels are currently not well understood. To improve our understanding of this process, we have conducted laboratory experiments to measure HO2 uptake coefficients onto submicron aerosol particles. The FAGE (Fluorescence Assay by Gas Expansion) technique, a highly sensitive laser induced fluorescence based detection method, was used to monitor HO2 uptake kinetics onto aerosol particles in an aerosol flow tube. The application of the FAGE technique allowed for kinetic experiments to be performed under low HO2 concentrations, i.e. [HO2] atomizing dilute salt solutions or by homogeneous nucleation. HO2 uptake coefficients (γ) have been measured for single-component solid and aqueous inorganic salt and organic aerosol particles with a wide range of hygroscopicities. HO2 uptake coefficients on solid particles were below the detection limit (γ < 0.001), whereas on aqueous aerosols uptake coefficients were somewhat larger (γ = 0.001 - 0.008). HO2 uptake coefficients were highest on aerosols containing metal ions, such as Cu and Fe. Humidity and aerosol pH did not significantly impact the reactive HO2 uptake. Preliminary experiments have also

  9. Coordinated mm/sub-mm observations of Sagittarius A* in May 2007

    Energy Technology Data Exchange (ETDEWEB)

    Kunneriath, D; Eckart, A; Bertram, T; Konig, S [University of Cologne, Zuelpicher Str. 77, D-50937 Cologne (Germany); Vogel, S [Department of Astronomy, University of Maryland, College Park, MD 20742-2421 (United States); Sjouwerman, L [National Radio Astronomy Observatory, PO Box 0, Socorro, NM 87801 (United States); Wiesemeyer, H [IRAM, Avenida Divina Pastora, 7, Nuecleo Central, E-18012 Granada (Spain); Schoedel, R [Instituto de AstrofIsica de AndalucIa, Camino Bajo de Huetor 50, 18008 Granada (Spain); Baganoff, F K [Center for Space Research, Massachusetts Institute of Technology, Cambridge, MA 02139-4307 (United States); Morris, M; Mauerhan, J; Meyer, L [Department of Physics and Astronomy, University of California, Los Angeles, CA 90095-1547 (United States); Dovciak, M; Karas, V [Astronomical Institute, Academy of Sciences, BocnI II, CZ-14131 Prague (Czech Republic); Dowries, D [Institut de Radio Astronomie Millimetrique, Domaine Universitaire, 38406 St. Martin d' Heres (France); Krichbaum, T; Lu, R-S [Max-Planck-Institut fuer Radioastronomie, Auf dem Huegel 69, 53121 Bonn (Germany); Krips, M [Harvard-Smithsonian Center for Astrophysics, SMA project, 60 Garden Street, MS 78 Cambridge, MA 02138 (United States); Markoff, S [Astronomical Institute ' Anton Pannekoek' , University of Amsterdam, Kruislaan 403, 1098SJ Amsterdam (Netherlands); Duschl, W J, E-mail: eckart@phl.uni-koeln.de (and others)

    2008-10-15

    At the center of the Milky Way, with a distance of {approx}8 kpc, the compact source Sagittarius A* (SgrA*) can be associated with a super massive black hole of {approx}4x 10{sup 6}M{sub o-dot}. SgrA* shows strong variability from the radio to the X-ray wavelength domains. Here we report on simultaneous NIR/sub-millimeter/X-ray observations from May 2007 that involved the NACO adaptive optics (AO) instrument at the European Southern Observatory's Very Large Telescope, the Australian Telescope Compact Array (ATCA), the US mm-array CARMA, the IRAM 30m mm-telescope, and other telescopes. We concentrate on the time series of mm/sub-mm data from CARMA, ATCA, and the MAMBO bolometer at the IRAM 30m telescope.

  10. Transportation studies: 40-MM collider dipole magnets

    International Nuclear Information System (INIS)

    Daly, E.

    1992-01-01

    Several fully functional 40-mm Collider Dipole Magnets (CDM) were instrumented with accelerometers to monitor shock and vibration loads during transport. The magnets were measured with optical tooling telescopes before and after transport. Changes in mechanical alignment due to shipping and handling were determined. The mechanical stability of the cryogen lines were checked using the same method. Field quality and dipole angle were measured warm before and after transport to determine changes in these parameters. Power spectra were calculated for accelerometers located on the cold mass, vacuum vessel, and trailer bed. Where available, plots of field quality and dipole roll both before and after were created. Shipping loads measured were largest in the vertical direction, where most of the structural deformation of the magnet was evident. It was not clear that magnetic performance was affected by the shipping and handling environment

  11. Effect of cationic size in Hg (Tl/Bi) Ba2Ca2Cu3O8+δ on ...

    Indian Academy of Sciences (India)

    In this paper we have reported investigations on the effect of simultaneous substitution of Bi and Tl at the H site in the oxygen deficient HO layer of HBa2Ca2Cu3O8+ cuprate superconductor. Bulk polycrystalline samples have been prepared by the two-step solid state reaction process (precursor route). It has been ...

  12. Diagnostický terminál spalovacího motoru na Pocket PC

    OpenAIRE

    Kubiš, Ján

    2008-01-01

    Moja bakalárska práca, v ktorej som mal vytvoriť programový systém pracujúci pod operačním systémom Windows CE 2003, sa zaoberá príjmaním a spracovaním dat, ktoré posiela riadiaca jednotka osmivalcového zážehového motoru Tatra T613/4i. Program je schopný príjmať jednotlivé tabuľky, ktoré riadiaca jednotka vysiela. Veličiny jednotlivých tabuliek je možné zobrazovať vo forme textových a číselných dat. Ďalej systém tiež vie zobrazovať chybné hlásenia, ktoré je riadiaca jednotka schopná posielať....

  13. Simulation of Thermal Processes in Metamaterial MM-to-IR Converter for MM-wave Imager

    International Nuclear Information System (INIS)

    Zagubisalo, Peter S; Paulish, Andrey G; Kuznetsov, Sergey A

    2014-01-01

    The main characteristics of MM-wave image detector were simulated by means of accurate numerical modelling of thermophysical processes in a metamaterial MM-to-IR converter. The converter represents a multilayer structure consisting of an ultra thin resonant metamaterial absorber and a perfect emissive layer. The absorber consists of a dielectric self-supporting film that is metallized from both sides. A micro-pattern is fabricated from one side. Resonant absorption of the MM waves induces the converter heating that yields enhancement of IR emission from the emissive layer. IR emission is detected by IR camera. In this contribution an accurate numerical model for simulation of the thermal processes in the converter structure was created by using COMSOL Multiphysics software. The simulation results are in a good agreement with experimental results that validates the model. The simulation shows that the real time operation is provided for the converter thickness less than 3 micrometers and time response can be improved by decreasing of the converter thickness. The energy conversion efficiency of MM waves into IR radiation is over 80%. The converter temperature increase is a linear function of a MM-wave radiation power within three orders of the dynamic range. The blooming effect and ways of its reducing are also discussed. The model allows us to choose the ways of converter structure optimization and improvement of image detector parameters

  14. Buccal mucosa carcinoma: surgical margin less than 3 mm, not 5 mm, predicts locoregional recurrence

    Directory of Open Access Journals (Sweden)

    Chiou Wen-Yen

    2010-09-01

    Full Text Available Abstract Background Most treatment failure of buccal mucosal cancer post surgery is locoregional recurrence. We tried to figure out how close the surgical margin being unsafe and needed further adjuvant treatment. Methods Between August 2000 and June 2008, a total of 110 patients with buccal mucosa carcinoma (25 with stage I, 31 with stage II, 11 with stage III, and 43 with Stage IV classified according to the American Joint Committee on Cancer 6th edition were treated with surgery alone (n = 32, surgery plus postoperative radiotherapy (n = 38 or surgery plus adjuvant concurrent chemoradiotherapy (n = 40. Main outcome measures: The primary endpoint was locoregional disease control. Results The median follow-up time at analysis was 25 months (range, 4-104 months. The 3-year locoregional control rates were significantly different when a 3-mm surgical margin (≤3 versus >3 mm, 71% versus 95%, p = 0.04 but not a 5-mm margin (75% versus 92%, p = 0.22 was used as the cut-off level. We also found a quantitative correlation between surgical margin and locoregional failure (hazard ratio, 2.16; 95% confidence interval, 1.14 - 4.11; p = 0.019. Multivariate analysis identified pN classification and surgical margin as independent factors affecting disease-free survival and locoregional control. Conclusions Narrow surgical margin ≤3 mm, but not 5 mm, is associated with high risk for locoregional recurrence of buccal mucosa carcinoma. More aggressive treatment after surgery is suggested.

  15. Buccal mucosa carcinoma: surgical margin less than 3 mm, not 5 mm, predicts locoregional recurrence

    International Nuclear Information System (INIS)

    Chiou, Wen-Yen; Hung, Shih-Kai; Lin, Hon-Yi; Hsu, Feng-Chun; Lee, Moon-Sing; Ho, Hsu-Chueh; Su, Yu-Chieh; Lee, Ching-Chih; Hsieh, Chen-Hsi; Wang, Yao-Ching

    2010-01-01

    Most treatment failure of buccal mucosal cancer post surgery is locoregional recurrence. We tried to figure out how close the surgical margin being unsafe and needed further adjuvant treatment. Between August 2000 and June 2008, a total of 110 patients with buccal mucosa carcinoma (25 with stage I, 31 with stage II, 11 with stage III, and 43 with Stage IV classified according to the American Joint Committee on Cancer 6 th edition) were treated with surgery alone (n = 32), surgery plus postoperative radiotherapy (n = 38) or surgery plus adjuvant concurrent chemoradiotherapy (n = 40). Main outcome measures: The primary endpoint was locoregional disease control. The median follow-up time at analysis was 25 months (range, 4-104 months). The 3-year locoregional control rates were significantly different when a 3-mm surgical margin (≤3 versus >3 mm, 71% versus 95%, p = 0.04) but not a 5-mm margin (75% versus 92%, p = 0.22) was used as the cut-off level. We also found a quantitative correlation between surgical margin and locoregional failure (hazard ratio, 2.16; 95% confidence interval, 1.14 - 4.11; p = 0.019). Multivariate analysis identified pN classification and surgical margin as independent factors affecting disease-free survival and locoregional control. Narrow surgical margin ≤3 mm, but not 5 mm, is associated with high risk for locoregional recurrence of buccal mucosa carcinoma. More aggressive treatment after surgery is suggested

  16. Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulation.

    Science.gov (United States)

    Hsu, Jun-Te; Kan, Wen-Hong; Hsieh, Chi-Hsun; Choudhry, Mashkoor A; Schwacha, Martin G; Bland, Kirby I; Chaudry, Irshad H

    2007-10-01

    Protein kinase B (Akt) is known to be involved in proinflammatory and chemotactic events in response to injury. Akt activation also leads to the induction of heme oxygenase (HO)-1. Up-regulation of HO-1 mediates potent, anti-inflammatory effects and attenuates organ injury. Although studies have shown that 17beta-estradiol (E2) prevents organ damage following trauma-hemorrhage, it remains unknown whether Akt/HO-1 plays any role in E2-mediated attenuation of hepatic injury following trauma-hemorrhage. To study this, male rats underwent trauma-hemorrhage (mean blood pressure, approximately 40 mmHg for 90 min), followed by fluid resuscitation. At the onset of resuscitation, rats were treated with vehicle, E2 (1 mg/kg body weight), E2 plus the PI-3K inhibitor (Wortmannin), or the estrogen receptor (ER) antagonist (ICI 182,780). At 2 h after sham operation or trauma-hemorrhage, plasma alpha-GST and hepatic tissue myeloperoxidase (MPO) activity, IL-6, TNF-alpha, ICAM-1, cytokine-induced neutrophil chemoattractant-1, and MIP-2 levels were measured. Hepatic Akt and HO-1 protein levels were also determined. Trauma-hemorrhage increased hepatic injury markers (alpha-GST and MPO activity), cytokines, ICAM-1, and chemokine levels. These parameters were markedly improved in the E2-treated rats following trauma-hemorrhage. E2 treatment also increased hepatic Akt activation and HO-1 expression compared with vehicle-treated, trauma-hemorrhage rats, which were abolished by coadministration of Wortmannin or ICI 182,780. These results suggest that the salutary effects of E2 on hepatic injury following trauma-hemorrhage are in part mediated via an ER-related, Akt-dependent up-regulation of HO-1.

  17. Magnetic state controllable critical temperature in epitaxial Ho/Nb bilayers

    Directory of Open Access Journals (Sweden)

    Yuanzhou Gu

    2014-04-01

    Full Text Available We study the magnetic properties of Ho thin films with different crystallinity (either epitaxial or non-epitaxial and investigate their proximity effects with Nb thin films. Magnetic measurements show that epitaxial Ho has large anisotropy in two different crystal directions in contrast to non-epitaxial Ho. Transport measurements show that the superconducting transition temperature (Tc of Nb thin films can be significantly suppressed at zero field by epitaxial Ho compared with non-epitaxial Ho. We also demonstrate a direct control over Tc by changing the magnetic states of the epitaxial Ho layer, and attribute the strong proximity effects to exchange interaction.

  18. Výložník kombinovaného skládkového stroje

    OpenAIRE

    Štursa, Martin

    2013-01-01

    Tato diplomová práce se zabývá konstrukcí částí kombinovaného skládkového stroje určeného pro obsluhu skládky hnědého uhlí u uhelné elektrárny. Nejprve jsou nadefinovány základní parametry stroje a silové účinky zatěžující stroj během provozu. Práce dále obsahuje návrh ocelové konstrukce kolesového výložníku, kolesa, korečků, pohonu kolesa, hřídele, ložisek a dalších částí kolesového výložníku. Tyto součásti jsou ověřeny analytickými nebo konečnoprvkovými výpočty. This master’s thesis deal...

  19. The electron capture in 163Ho experiment - ECHo

    Science.gov (United States)

    Gastaldo, L.; Blaum, K.; Chrysalidis, K.; Day Goodacre, T.; Domula, A.; Door, M.; Dorrer, H.; Düllmann, Ch. E.; Eberhardt, K.; Eliseev, S.; Enss, C.; Faessler, A.; Filianin, P.; Fleischmann, A.; Fonnesu, D.; Gamer, L.; Haas, R.; Hassel, C.; Hengstler, D.; Jochum, J.; Johnston, K.; Kebschull, U.; Kempf, S.; Kieck, T.; Köster, U.; Lahiri, S.; Maiti, M.; Mantegazzini, F.; Marsh, B.; Neroutsos, P.; Novikov, Yu. N.; Ranitzsch, P. C. O.; Rothe, S.; Rischka, A.; Saenz, A.; Sander, O.; Schneider, F.; Scholl, S.; Schüssler, R. X.; Schweiger, Ch.; Simkovic, F.; Stora, T.; Szücs, Z.; Türler, A.; Veinhard, M.; Weber, M.; Wegner, M.; Wendt, K.; Zuber, K.

    2017-06-01

    Neutrinos, and in particular their tiny but non-vanishing masses, can be considered one of the doors towards physics beyond the Standard Model. Precision measurements of the kinematics of weak interactions, in particular of the 3H β-decay and the 163Ho electron capture (EC), represent the only model independent approach to determine the absolute scale of neutrino masses. The electron capture in 163Ho experiment, ECHo, is designed to reach sub-eV sensitivity on the electron neutrino mass by means of the analysis of the calorimetrically measured electron capture spectrum of the nuclide 163Ho. The maximum energy available for this decay, about 2.8 keV, constrains the type of detectors that can be used. Arrays of low temperature metallic magnetic calorimeters (MMCs) are being developed to measure the 163Ho EC spectrum with energy resolution below 3 eV FWHM and with a time resolution below 1 μs. To achieve the sub-eV sensitivity on the electron neutrino mass, together with the detector optimization, the availability of large ultra-pure 163Ho samples, the identification and suppression of background sources as well as the precise parametrization of the 163Ho EC spectrum are of utmost importance. The high-energy resolution 163Ho spectra measured with the first MMC prototypes with ion-implanted 163Ho set the basis for the ECHo experiment. We describe the conceptual design of ECHo and motivate the strategies we have adopted to carry on the present medium scale experiment, ECHo-1K. In this experiment, the use of 1 kBq 163Ho will allow to reach a neutrino mass sensitivity below 10 eV/ c 2. We then discuss how the results being achieved in ECHo-1k will guide the design of the next stage of the ECHo experiment, ECHo-1M, where a source of the order of 1 MBq 163Ho embedded in large MMCs arrays will allow to reach sub-eV sensitivity on the electron neutrino mass.

  20. Deleterious effects on MDAMB-231 breast adenocarcinoma cell lineage submitted to Ho-166 radioactive seeds at very low activity

    Energy Technology Data Exchange (ETDEWEB)

    Falcao, Patricia L.; Campos, Tarcisio P.R., E-mail: campos@nuclear.ufmg.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Engenharia Nuclear; Sarmento, Eduardo V. [Centro de Desenvolvimento de Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Cuperschmid, Ethel M. [Universidade Federal de Minas Gerais (CEMEMOR/UFMG), Belo Horizonte, BR (Brazil). Fac. de Medicina. Centro de Memoria da Medicina

    2011-07-01

    Herein, the deleterious effect of ionizing radiation provided by Ho-166 radioactive seeds at low activity were addressed, based on experimental in vitro assays at the MDA MB231 cell lineage, a breast adenocarcinoma, compared to PBMC - peripheral blood cells. The methodology involves of the MDBMB-231 and PBMC expansion in culture in suitable environment in 30mm well plates and T-25 flasks. Seeds were synthesized with Ho-165 incorporated and characterized previously. Activation was processed at IPR1 reactor at the peripheral table, at 8h exposition. Three groups of seeds were tested: 0,34 mCi, 0,12 mCi activity, and control group. Such seeds were placed on culture and held to a period of 05 half-lives of the radionuclide. The biological responses at these exposure were documented by inverse microscopic photographic in time. Also, MTT essay were performed. A fast response in producing deleterious effects at cancer cell was observed even if for the low activity seeds. Also, a biological response dependent to a radial distance of the seed was observed. At conclusion, viability clonogenic control of MDAMB231 is identified at the exposition to Ho-166 ceramic seeds, even if at low activity of 0,1 to 0,3mCi. (author)

  1. Deleterious effects on MDAMB-231 breast adenocarcinoma cell lineage submitted to Ho-166 radioactive seeds at very low activity

    International Nuclear Information System (INIS)

    Falcao, Patricia L.; Campos, Tarcisio P.R.; Cuperschmid, Ethel M.

    2011-01-01

    Herein, the deleterious effect of ionizing radiation provided by Ho-166 radioactive seeds at low activity were addressed, based on experimental in vitro assays at the MDA MB231 cell lineage, a breast adenocarcinoma, compared to PBMC - peripheral blood cells. The methodology involves of the MDBMB-231 and PBMC expansion in culture in suitable environment in 30mm well plates and T-25 flasks. Seeds were synthesized with Ho-165 incorporated and characterized previously. Activation was processed at IPR1 reactor at the peripheral table, at 8h exposition. Three groups of seeds were tested: 0,34 mCi, 0,12 mCi activity, and control group. Such seeds were placed on culture and held to a period of 05 half-lives of the radionuclide. The biological responses at these exposure were documented by inverse microscopic photographic in time. Also, MTT essay were performed. A fast response in producing deleterious effects at cancer cell was observed even if for the low activity seeds. Also, a biological response dependent to a radial distance of the seed was observed. At conclusion, viability clonogenic control of MDAMB231 is identified at the exposition to Ho-166 ceramic seeds, even if at low activity of 0,1 to 0,3mCi. (author)

  2. Comparative in vitro study of tissue welding using a 808 nm diode laser and a Ho:YAG laser.

    Science.gov (United States)

    Ott, B; Züger, B J; Erni, D; Banic, A; Schaffner, T; Weber, H P; Frenz, M

    2001-01-01

    In vitro porcine arteries and veins have been welded end-to-end using either a 808 nm diode laser combined with an indocyanine green enhanced albumin solder, or with a continuous-wave (cw) Ho:YAG laser without biological solder. The vascular stumps were approached to each other over a coronary dilatation catheter in order to obtain a precise alignment and good coaptation. Standard histology revealed for both welding techniques lateral tissue damage between 2 and 3 mm caused by laser-induced heat. Good solder attachment to the tissue was observed by the use of a scanning electron microscope. The vessels soldered with the 808 nm diode laser using albumin solder showed considerably higher tensile strength (1 N compared to 0.3 N) than vessels welded exclusively by Ho:YAG laser radiation. In contrast, leaking pressure (350 +/- 200 mmHg) and bursting pressure (457 +/- 200 mmHg) were found to be independent of the welding technique used. This study demonstrates that fast (total welding time about 2-5 min), stable and tight microvascular anastomosis can be achieved with the use of a dye-enhanced albumin laser soldering technique and an ancillary coronary dilatation catheter.

  3. PWV, Temperature and Wind Statistics at Sites Suitable For mm and Sub-mm Wavelengths Astronomy

    Science.gov (United States)

    Otarola, Angel; Travouillon, Tony; De Breuck, Carlos; Radford, Simon; Matsushita, Satoki; Pérez-Beaupuits, Juan P.

    2018-01-01

    Atmospheric water vapor is the main limiting factor of atmospheric transparency in the mm and sub-mm wavelength spectral windows. Thus, dry sites are needed for the installation and successful operation of radio astronomy observatories exploiting those spectral windows. Other parameters that play an important role in the mechanical response of radio telescopes exposed to the environmental conditions are: temperature, and in particular temperature gradients that induce thermal deformation of mechanical structures, as well as wind magnitude that induce pointing jitter affecting this way the required accuracy in the ability to point to a cosmic source during the observations. Temperature and wind are variables of special consideration when planning the installation and operations of large aperture radio telescopes. This work summarizes the statistics of precipitable water vapor (PWV), temperature and wind monitored at sites by the costal mountain range, as well as on t he west slope of the Andes mountain range in the region of Antofagasta, Chile. This information could prove useful for the planning of the Atacama Large-Aperture Submm/mm Telescope (AtLast).

  4. Impact of seawater [Ca

    NARCIS (Netherlands)

    Mewes, A.; Langer, G.; Thoms, S.; Nehrke, G.; Reichart, G.J.; de Nooijer, L.J.; Bijma, J.

    2015-01-01

    Mg / Ca ratios in foraminiferal tests are routinely used as paleotemperature proxies, but on long timescales, they also hold the potential to reconstruct past seawater Mg / Ca. The impact of both temperature and seawater Mg / Ca on Mg incorporation in Foraminifera has been quantified by a number of

  5. Observations of OH and HO2 radicals in coastal Antarctica

    Directory of Open Access Journals (Sweden)

    S. J.-B. Bauguitte

    2007-08-01

    Full Text Available OH and HO2 radical concentrations have been measured in the boundary layer of coastal Antarctica for a six-week period during the austral summer of 2005. The measurements were performed at the British Antarctic Survey's Halley Research Station (75° 35' S, 26° 19' W, using the technique of on-resonance laser-induced fluorescence to detect OH, with HO2 measured following chemical conversion through addition of NO. The mean radical levels were 3.9×105 molecule cm−3 for OH, and 0.76 ppt for HO2 (ppt denotes parts per trillion, by volume. Typical maximum (local noontime levels were 7.9×105 molecule cm−3 and 1.50 ppt for OH and HO2 respectively. The main sources of HOx were photolysis of O3 and HCHO, with potentially important but uncertain contributions from HONO and higher aldehydes. Of the measured OH sinks, reaction with CO and CH4 dominated, however comparison of the observed OH concentrations with those calculated via the steady state approximation indicated that additional co-reactants were likely to have been present. Elevated levels of NOx resulting from snowpack photochemistry contributed to HOx cycling and enhanced levels of OH, however the halogen oxides IO and BrO dominated the CH3O2 – HO2 – OH conversion in this environment, with associated ozone destruction.

  6. A Dual-Crystal Cavity Ho,Tm:GdVO4 Laser

    International Nuclear Information System (INIS)

    Zhu Guo-Li; Ju You-Lun; Yao Bao-Quan; Wang Yue-Zhu

    2012-01-01

    We report a 31.2 W cw diode-pumped cryogenic Ho(0.4at.%),Tm(4at.%):GdVO 4 laser in a dual-crystal cavity. The pumping sources are two fiber-coupled laser diodes with a fiber core diameter of 0.4 mm, both of which can supply 42 W near 802 nm. With an incident pump power of 70.3 W at 802.4 nm, a cw output power of 31.2 W at 2.05 μm is attained, corresponding to an optical-to-optical conversion efficiency of 44.4%. The M 2 factor is measured as ∼1.3 under an output power of 20 W. (fundamental areas of phenomenology(including applications))

  7. Embedding of $^{163}$Ho and $^{166m}$ Ho in the energy absorbers of low temperature metallic magnetic calorimeters

    CERN Multimedia

    The calorimetric measurement of the $^{163}$Ho electron capture spectrum is a promising tool to investigate the electron neutrino mass. A suitable method to embed the source in the detectors is the ion-implantation. This process has already been used to embed $^{163}$Ho ions in micro-fabricated low temperature metallic magnetic prototypes. The $^{163}$Ho electron capture spectrum obtained with these first prototypes is presently the most precise with an energy resolution of $\\Delta$$\\textit{E}$$_{FWHM}$ = 7.6 eV. In order to test the performance of the new generation of low temperature metallic magnetic calorimeters, we propose to perform a $^{163}$Ho ion-implantation on the new chip having two arrays consisting of 32 pixels each. An activity of about 1 Bq per pixel is required. With this new detector array we will be able to achieve a better energy resolution and to acquire a higher statistics which allows for studying the $^{163}$Ho spectral shape. We propose also to perform an ion-implantation of $^{166m}$...

  8. Návrh internetového obchodu pro firmu

    OpenAIRE

    Fikáčková, Barbora

    2007-01-01

    Bakalářské práce analyzuje problémy související s tvorbou internetového obchodu. Obsahuje návrh vhodného řešení pro zlepšení budoucího postavení firmy AMAR marketing s.r.o. a jeho ekonomické zhodnocení. Bachelor work analyzes problems in connection with creation of internet shop. for the firm AMAR marketing s.r.o. It contains analysis of suitable solution, leading to improve future position of the firm AMAR marketing s.r.o. and its econo-mic evulation. A

  9. Proton Radioactivity Measurements at HRIBF: Ho, Lu, and Tm Isotopes

    International Nuclear Information System (INIS)

    Akovali, Y.; Batchelder, J.C.; Bingham, C.R.; Davinson, T.; Ginter, T.N.; Gross, C.J.; Grzywacz, R.; Hamilton, J.H.; Janas, Z.; Karny, M.; Kim, S.H.; MacDonald, B.D.; Mas, J.F.; McConnell, J.W.; Piechaczek, A.; Ressler, J.J.; Rykaczewski, K.; Slinger, R.C.; Szerypo, J.; Toth, K.S.; Weintraub, W.; Woods, P.J.; Yu, C.-H.; Zganjar, E.F.

    1998-01-01

    Two new isotopes, 145 Tm and 140 Ho and three isomers in previously known isotopes, 141m Ho, 150m Lu and 151m Lu have been discovered and studied via their decay by proton emission. These proton emitters were produced at the Holifield Radioactive Ion Beam Facility (HRIBF) by heavy-ion fusion-evaporation reactions, separated in A/Q with a recoil mass spectrometer (RMS), and detected in a double-sided silicon strip detector (DSSD). The decay energy and half-life was measured for each new emitter. An analysis in terms of a spherical shell model is applied to the Tm and Lu nuclei, but Ho is considerably deformed and requires a collective model interpretation

  10. Návrh výroby chytrého stojanu s využitím moderních metod a technologií

    OpenAIRE

    Buchta, Juraj

    2017-01-01

    Cieľom bakalárskej práce je návrh, konštrukcia a výroba chytrého stojanu pre laptop Macbook Pro s využitím modernej aditívnej technológie Rapid Prototyping. Návrh je vytvorený pomocou parametrického CAD programu SolidWorks. Model stojana je vytlačený na 3D tlačiarni Fortus, ktorá pracuje na princípe aditívnej metódy Fused Deposition Modeling. Práca je ukončená ekonomickým zhodnotením celkových nákladov na výrobu a cenovým zrovnaním stojanov dostupných na trhu. The aim of bachelor´s thesis ...

  11. Protection induced by external Ca 2+ application on proline ...

    African Journals Online (AJOL)

    treated (100 mM NaCl) mustard plant (Sinapis alba L.) was investigated in relation to ion uptake, proline, chlorophyll a&b, protein and ABA concentrations. Salinity treatment (100 mM NaCl) led to significant decreases in Ca2+& Kuptake and Chl. a&b ...

  12. The LLAMA 12 m mm/sub-mm radiotelescope in the Andes

    Science.gov (United States)

    Lepine, Jacques; Edemundo Arnal, Marcelo; de Graauw, Thijs; Abraham, Zulema; Gimenez de Castro, Guillermo; de Gouveia Dal Pino, Elisabete; Morras, Ricardo; Larrarte, Juan; Viramontes, José; Finger, Ricardo; Kooi, Jacob; Reeves, Rodrigo; Beaklini, Pedro

    2015-08-01

    LLAMA (Large Latin American Millimetric Array) is a joint Argentinean-Brazilian project of a 12m mm/sub-mm radio telescope similar to the APEX antenna, to be installed at a site at 4800 m altitude near San Antonio de Los Cobres in the Salta Province in Argentine, at 150 km from ALMA. The scientific cases for single dish and VLBI observations include black holes and accretion disks, the molecular evolution of interstellar clouds, the structure of the Galaxy, the formation of galaxies, and much more. The antenna was ordered to the company Vertex Antennentechnik in June 2014, and the construction is progressing quickly; it will be installed at the site in 2016. The radio telescope will be equipped with up to six receivers covering bands similar to those of ALMA. Cryostats with room for 3 cartridges, constructed by NAOJ (Tokyo,Japan), will be installed in each of the two Nasmyth cabins. Among the first receivers we will have an ALMA band 9 provided by NOVA (Groningen, Holland) and a band 5 from the Chalmers University (Sweden). Other receivers are still being discussed at the time of submission of this abstract,At high frequencies, VLBI observations at high frequencies could be made with ALMA, APEX and ASTE, and Northern radiotelescopes. In this way, LLAMA will be a seed for a Latin-American VLBI network.

  13. Ca(2+-dependent regulation of the Ca(2+ concentration in the myometrium mitochondria. II. Ca(2+ effects on mitochondria membranes polarization and [Ca(2+](m

    Directory of Open Access Journals (Sweden)

    L. G. Babich

    2017-06-01

    Full Text Available It is known that Ca2+ accumulation in the mitochondria undergoes complex regulation by Ca2+ itself. But the mechanisms of such regulation are still discussed. In this paper we have shown that Ca ions directly or indirectly regulate the level of myometrium mitochondria membranes polarization. The additions of 100 µM Ca2+ were accompanied by depolarization of the mitochondria membranes. The following experiments were designed to study the impact of Ca2+ on the myometrium mitochondria [Ca2+]m. Isolated myometrium mitochondria were preincubated without or with 10 μM Са2+ followed by 100 μM Са2+ addition. Experiments were conducted in three mediums: without ATP and Mg2+ (0-medium, in the presence of 3 mM Mg2+ (Mg-medium and 3 mM Mg2+ + 3 mM ATP (Mg,ATP-medium. It was shown that the effects of 10 μM Са2+ addition were different in different mediums, namely in 0- and Mg-medium the [Ca2+]m values increased, whereas in Mg,ATP-medium statistically reliable changes were not registered. Preincubation of mitochondria with 10 μM Са2+ did not affect the [Ca2+]m value after the addition of 100 μM Са2+. The [Ca2+]m values after 100 μM Са2+ addition were the same in 0- and Mg,ATP-mediums and somewhat lower in Mg-medium. Preliminary incubation of mitochondria with 10 μM Са2+ in 0- and Mg-mediums reduced changes of Fluo 4 normalized fluorescence values that were induced by 100 μM Са2+ additions, but in Mg,ATP-medium such differences were not recorded. It is concluded that Са2+ exchange in myometrium mitochondria is regulated by the concentration of Ca ions as in the external medium, so in the matrix of mitochondria. The medium composition had a significant impact on the [Са2+]m values in the absence of exogenous cation. It is suggested that light increase of [Са2+]m before the addition of 100 μM Са2+ may have a positive effect on the functional activity of the mitochondria.

  14. Lattice effects in HoVo3 single crystal

    International Nuclear Information System (INIS)

    Sikora, M.; Marquina, C.; Ibarra, M.R.; Nugroho, A.A.; Palstra, T.T.M.

    2007-01-01

    We report the study of lattice effects in the Mott insulator HoVO 3 performed by means of linear thermal expansion on a single crystal in the temperature range 10-290 K. The holmium orthovanadate HoVO 3 reveals gradual orbital ordering (OO) below T OO =200 K and orders antiferromagnetically at T N =113 K. A first-order structural phase transition takes place at T S ∼38 K, which is probably accompanied by change of the OO type and hence the type of antiferromagnetic spin ordering

  15. The uptake of HO2 radicals to organic aerosols

    Science.gov (United States)

    Matthews, Pascale; Krapf, Manuel; Dommen, Josef; George, Ingrid; Whalley, Lisa; Ingham, Trevor; Baeza-Romero, Maria Teresa; Ammann, Markus; Heard, Dwayne

    2014-05-01

    HOx (OH + HO2) radicals are responsible for the majority of the oxidation in the troposphere and control the concentrations of many trace species in the atmosphere. There have been many field studies where the measured HO2 concentrations have been smaller than the concentration predicted by model calculations [1,2]. The difference has often been attributed to HO2 uptake by aerosols. Organics are a major component of aerosols accounting for 10 - 70 % of their mass [3]. However, there have been very few laboratory studies measuring HO2 uptake onto organic aerosols [4]. Uptake coefficients (γ) were measured for a range of aerosols using a Fluorescence Assay By Gas Expansion (FAGE) detector combined with an aerosol flow tube. HO2 was injected into the flow tube using a moveable injector which allowed first order HO2 decays to be measured along the flow tube both with and without aerosols. Laboratory generated aerosols were made using an atomiser or by homogeneous nucleation. Secondary organic aerosols (SOA) were made using the Paul Scherrer Institute smog chamber and also by means of a Potential Aerosol Mass (PAM) chamber. The total aerosol surface area was then measured using a Scanning Mobility Particle Sizer (SMPS). Experiments were carried out on aerosols containing glutaric acid, glyoxal, malonic acid, stearic acid, oleic acid and squalene. The HO2 uptake coefficients for these species were measured in the range of γ contained elevated levels of transition metal ions. For humic acid the uptake coefficient was highly dependent on humidity and this may be explained by the liquid water content of the aerosols. Measurements were also performed on copper doped aerosols containing different organics. An uptake coefficient of 0.23 ± 0.07 was measured for copper doped ammonium sulphate, however, this was reduced to 0.008 ± 0.009 when EDTA was added in a 1:1 ratio with copper and 0.003 ± 0.004 when oxalic acid was added in a 10:1 ratio with copper. SOA aerosols were

  16. Polyamines mediate abnormal Ca2+ transport and Ca2+-induced cardiac cell injury in the calcium paradox

    International Nuclear Information System (INIS)

    Trout, J.J.; Koenig, H.; Goldstone, A.D.; Lu, C.Y.; Fan, C.C.

    1986-01-01

    Ca 2+ -free perfusion renders heart cells Ca 2+ -sensitive so that readmission of Ca 2+ causes a sudden massive cellular injury attributed to abnormal entry of Ca 2+ into cells (Ca paradox). Hormonal stimulation of Ca 2+ fluxes was earlier shown to be mediated by polyamines (PA). 5 min perfusion of rat heart with Ca 2+ -free medium induce a prompt 40-50% decline in levels of the PA putrescine (PUT), spermidine and spermine and their rate-regulatory synthetic enzyme ornithine decarboxylase (ODC), and readmission of Ca 2+ -containing medium abruptly ( 2+ reperfusion-induced increases in ODC and PA and also prevented increased 45 Ca 2+ uptake and heart injury, manifested by loss of contractility, release of enzymes (CPK, LDH), myoglobin and protein, and E.M. lesions (contracture bands, mitochondrial changes). 1 mM PUT negated DFMO inhibition, repleted heart PA and restored Ca 2+ reperfusion-induced 45 Ca 2+ influx and cell injury. These data indicate that the Ca 2+ -directed depletion-repletion cycle of ODC and PA triggers excessive transsarcolemmal Ca 2+ transport leading to the calcium paradox

  17. 166Ho-chitosan as a radiation synovectomy agent - biocompatibility study of 166Ho-chitosan in rabbits

    International Nuclear Information System (INIS)

    Kim, Sug Jun; Lee, Soo Yong; Jeon, Dae Geun; Lee Jong Seok

    1997-01-01

    Radiation synovectomy is a noninvasive therapy that has been investigated as an alternative to surgical synovectomy. It is been successfully employed in the treatment of synovitis in rheumatoid arthrits and other inflammatory arthropathies. We developed the 166 Ho-chitosan complex for possible use as a radiation synovectomy agent. Holmium is the more practical isotope based on its higher radioactivity and logner half-life. And isotope based on its higher radioactivity and logner half-life. And chitosan is ideal and suitable particles based on its soluble and biodegradable characteristics. So we investigated the biocompatibility of the 166 Ho-chitosan complex to evaluated the suitability as a radiation synovectomy agent. In this study, we performed in vivo and in vitro stability test and biodistribution test. Our results indicate that 166 Ho-chitosan may be an effective radiopharmaceutical for radiation synovectomy. (author). 30 refs., 7 tabs

  18. {sup 166}Ho-chitosan as a radiation synovectomy agent - biocompatibility study of {sup 166}Ho-chitosan in rabbits

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sug Jun; Lee, Soo Yong; Jeon, Dae Geun; Seok, Lee Jong [Korea Cancer Center Hospital, Seoul (Korea, Republic of)

    1997-01-01

    Radiation synovectomy is a noninvasive therapy that has been investigated as an alternative to surgical synovectomy. It is been successfully employed in the treatment of synovitis in rheumatoid arthrits and other inflammatory arthropathies. We developed the {sup 166}Ho-chitosan complex for possible use as a radiation synovectomy agent. Holmium is the more practical isotope based on its higher radioactivity and logner half-life. And isotope based on its higher radioactivity and logner half-life. And chitosan is ideal and suitable particles based on its soluble and biodegradable characteristics. So we investigated the biocompatibility of the {sup 166}Ho-chitosan complex to evaluated the suitability as a radiation synovectomy agent. In this study, we performed in vivo and in vitro stability test and biodistribution test. Our results indicate that {sup 166}Ho-chitosan may be an effective radiopharmaceutical for radiation synovectomy. (author). 30 refs., 7 tabs.

  19. Electronic transitions of Ho in Pb2Sr2HoCu3O8 observed by inelastic neutron scattering

    International Nuclear Information System (INIS)

    Soderholm, L.; Loong, C.; Xue, J.S.; Hammonds, J.P.; Greedan, J.E.; Maric, M.

    1993-01-01

    The electronic behavior of the 5 I 8 Russell Saunders ground multiplet of Ho 3+ in Pb 2 Sr 2 HoCu 3 O 8 has been investigated using inelastic neutron scattering. We observe ten peaks in the excitation spectra that are associated with crystal field transitions. The peaks are only slightly broader than expected from instrument resolution, indicating that there are no strong interactions between the local Ho f states and the CuO conduction states. Comparing the energies and intensities of the experimental peaks with those expected from modeling convinces us that there are at least three states populated at the temperature of our experiment (15 K), making the assignments of transitions very difficult in the absence of further data

  20. Failure analysis of large tube of maraging steel 350 (145 mm dia, 1 mm wall thickness)

    International Nuclear Information System (INIS)

    Shamim, A.

    1997-01-01

    A steady of opening mode of crack initiation in maraging steel 350 rotor tubes aged and rolled condition (1 mm thick sheet) has been constructed, with the aid of a (NEOPHOT 2) microscope. Observations were made from several orientations including the top view of the specimen which showed the profile and the edge view of the specimen which showed the entire notch front along the specimen thickness. It was found that the edge view exhibited the first signs of permanent deformation. These changes took the form of deformation bends which were aligned in direction of the tensile axis and apparently defined limiting regions of homogeneous slip. It is felt that the appearance of microcracks at loads approaching the breaking strength was of fundamental importance in the formation of the final fracture surface. Many of these microcracks were initiated at intermetallic particles and other metallurgically weak regions on the notch surface. (author)

  1. Optical transitions of Ho(3+) in oxyfluoride glasses and upconversion luminescence of Ho(3+)/Yb(3+)-codoped oxyfluoride glasses.

    Science.gov (United States)

    Feng, Li; Wu, Yinsu

    2015-05-05

    Optical properties of Ho(3+)-doped SiO2-BaF2-ZnF2 glasses have been investigated on the basis of the Judd-Ofelt theory. Judd-Ofelt intensity parameters, radiative transition probabilities, fluorescence branching ratios and radiative lifetimes have been calculated for different glass compositions. Upconversion emissions were observed in Ho(3+)/Yb(3+)-codoped SiO2-BaF2-ZnF2 glasses under 980nm excitation. The effects of composition, concentration of the doping ions, and excitation pump power on the upconversion emissions were also systematically studied. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. crdi.ca

    International Development Research Centre (IDRC) Digital Library (Canada)

    et des enfants d'Afrique. INITIATIVE CONCERTÉE. Innovation pour la santé des mères et des enfants d'Afrique. Centre de recherches pour le développement international. CP Box 8500 Ottawa ON Canada K1G 3H9. Téléphone : +1 613 236 6163 • Télécopieur : +1 613 657 7749 ismea@crdi.ca | www.crdi.ca/ismea crdi.ca.

  3. Sulforaphane protects rodent retinas against ischemia-reperfusion injury through the activation of the Nrf2/HO-1 antioxidant pathway.

    Directory of Open Access Journals (Sweden)

    Hong Pan

    Full Text Available Retinal ischemia-reperfusion (I/R injury induces oxidative stress, leukocyte infiltration, and neuronal cell death. Sulforaphane (SF, which can be obtained in cruciferous vegetables such as broccoli, exerts protective effects in response to oxidative stress in various tissues. These effects can be initiated through nuclear factor E2-related factor 2 (Nrf2-mediated induction of heme oxygenase-1 (HO-1. This investigation was designed to elucidate the neural protective mechanisms of SF in the retinal I/R rat model. Animals were intraperitoneally (i.p. injected with SF (12.5 mg/kg or vehicle (corn oil once a day for 7 consecutive days. Then, retinal I/R was made by elevating the intraocular pressure (IOP to 130 mmHg for 1 h. To determine if HO-1 was involved in the Nrf2 antioxidant pathway, rats were subjected to protoporphyrin IX zinc (II (ZnPP, 30 mg/kg, i.p. treatments at 24 h before retinal ischemia. The neuroprotective effects of SF were assessed by determining the morphology of the retina, counting the infiltrating inflammatory cells and the surviving retinal ganglion cells (RGCs and amacrine cells, and measuring apoptosis in the retinal layers. The expression of Nrf2 and HO-1 was studied by immunofluorescence analysis and western blotting. I/R induced a marked increase of ROS generation, caused pronounced inflammation, increased the apoptosis of RGCs and amacrine cells and caused the thinning of the inner retinal layer (IRL, and these effects were diminished or abolished by SF pretreatment. Meanwhile, SF pretreatment significantly elevated the nuclear accumulation of Nrf2 and the level of HO-1 expression in the I/R retinas; however, ZnPP reversed the protective effects of SF on I/R retinas. Together, we offer direct evidence that SF had protective effects on I/R retinas, which could be attributed, at least in part, to the activation of the Nrf2/HO-1 antioxidant pathway.

  4. INTRACELLULAR Ca2+ HOMEOSTASIS

    Directory of Open Access Journals (Sweden)

    Shahdevi Nandar Kurniawan

    2015-01-01

    Full Text Available Ca2+ signaling functions to regulate many cellular processes. Dynamics of Ca2+ signaling or homeostasis is regulated by the interaction between ON and OFF reactions that control Ca2+ flux in both the plasma membrane and internal organelles such as the endoplasmic reticulum (ER and mitochondria. External stimuli activate the ON reactions, which include Ca2+ into the cytoplasm either through channels in the plasma membrane or from internal storage like in ER. Most of the cells utilize both channels/sources, butthere area few cells using an external or internal source to control certain processes. Most of the Ca2+ entering the cytoplasm adsorbed to the buffer, while a smaller part activate effect or to stimulate cellular processes. Reaction OFF is pumping of cytoplasmic Ca2+ using a combination mechanism of mitochondrial and others. Changes in Ca2+ signal has been detected in various tissues isolated from animals induced into diabetes as well as patients with diabetes. Ca2+ signal interference is also found in sensory neurons of experimental animals with diabetes. Ca2+ signaling is one of the main signaling systems in the cell.

  5. Sporadic Creutzfeldt-Jakob Disease MM1+2C and MM1 are Identical in Transmission Properties.

    Science.gov (United States)

    Kobayashi, Atsushi; Matsuura, Yuichi; Iwaki, Toru; Iwasaki, Yasushi; Yoshida, Mari; Takahashi, Hitoshi; Murayama, Shigeo; Takao, Masaki; Kato, Shinsuke; Yamada, Masahito; Mohri, Shirou; Kitamoto, Tetsuyuki

    2016-01-01

    The genotype (methionine, M or valine, V) at polymorphic codon 129 of the PRNP gene and the type (1 or 2) of abnormal prion protein in the brain are the major determinants of the clinicopathological features of sporadic Creutzfeldt-Jakob disease (CJD), thus providing molecular basis for classification of sporadic CJD, that is, MM1, MM2, MV1, MV2, VV1 or VV2. In addition to these "pure" cases, "mixed" cases presenting mixed neuropathological and biochemical features have also been recognized. The most frequently observed mixed form is the co-occurrence of MM1 and MM2, namely MM1+2. However, it has remained elusive whether MM1+2 could be a causative origin of dura mater graft-associated CJD (dCJD), one of the largest subgroups of iatrogenic CJD. To test this possibility, we performed transmission experiments of MM1+2 prions and a systematic neuropathological examination of dCJD patients in the present study. The transmission properties of the MM1+2 prions were identical to those of MM1 prions because MM2 prions lacked transmissibility. In addition, the neuropathological characteristics of MM2 were totally absent in dCJD patients examined. These results suggest that MM1+2 can be a causative origin of dCJD and causes neuropathological phenotype similar to that of MM1. © 2015 International Society of Neuropathology.

  6. 2.07-micron CW diode-laser-pumped Tm,Ho:YLiF4 room-temperature

    Science.gov (United States)

    Hemmati, Hamid

    1989-01-01

    Continuous-wave action is obtained at 2.07 microns from a 2-mm-long Tm-sensitized Ho:YLiF4 crystal at room temperature when longitudinally pumped by a pair of diode-laser arrays. Laser output power at 300 K is 26 mW, with a 30-percent slope efficiency and a lasing threshold of 108 mW. A maximum output power of 187 mW is obtained from a 4-mm-long crystal at 77 K, with a 67 percent slope efficiency. A preliminary demonstration of cavity Q switching produced 165 microJ of pulse energy at a repetition rate of 100 Hz.

  7. Charged black holes in Hořava gravity

    International Nuclear Information System (INIS)

    Janiszewski, Stefan; Karch, Andreas; Robinson, Brandon; Sommer, David

    2014-01-01

    We explore static spherically symmetric black hole solutions allowing a bulk U(1) vector field in the khronometric formulation of Hořava gravity by way of Einstein-Æther. We examine analytic solutions and study numerical results in the limit that the khronon does not backreact on the metric

  8. Programme Note: Realities and Opportunities in Ho Chi Minh City.

    Science.gov (United States)

    Franchet, Chi Nguyen

    1996-01-01

    The current status of street children in Ho Chi Minh City, Vietnam, is characterized by marginalization from society through street vending, begging, theft, and prostitution. Evaluation of a drop-in center serving children without family linkages indicates need for needs assessments, follow-up activities, measurement of individual child progress,…

  9. Phase equilibria of the Mo-Al-Ho ternary system

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yitai; Chen, Xiaoxian; Liu, Hao [Guangxi Univ., Nanning (China). College of Materials Science and Engineering; Guangxi Univ., Nanning (China). Guangxi Key Laboratory of Processing for Non-ferrous Metal and Featured Materials; Zhan, Yongzhong [Guangxi Univ., Nanning (China). College of Materials Science and Engineering; Guangxi Univ., Nanning (China). Guangxi Key Laboratory of Processing for Non-ferrous Metal and Featured Materials; Guangxi Univ., Nanning (China). Center of Ecological Collaborative Innovation for Aluminum Industry

    2017-08-15

    Investigation into the reactions and phase equilibria of transition metal elements (i.e. Mo, Zr, Cr, V and Ti), Al and rare earths is academically and industrially important for the development of both refractory alloys and lightweight high-temperature materials. In this work, the equilibria of the Mo-Al-Ho ternary system at 773 K have been determined by using X-ray powder diffraction and scanning electron microscopy equipped with energy dispersive X-ray analysis. A new ternary phase Al{sub 4}Mo{sub 2}Ho has been found and the other ternary phase Al{sub 43}Mo{sub 4}Ho{sub 6} is observed. Ten binary phases in the Al-Mo and Al-Ho systems, including Al{sub 17}Mo{sub 4} rather than Al{sub 4}Mo, have been determined to exist at 773 K. The homogeneity ranges of AlMo{sub 3} and Al{sub 8}Mo{sub 3} phase are 7.5 at.% and 1 at.%, respectively. According to the phase-disappearing method, the maximum solubility of Al in Mo is about 16 at.%.

  10. Antiferromagnetism in a 20% Ho-80% Tb alloy single crystal

    DEFF Research Database (Denmark)

    Lebech, Bente

    1968-01-01

    20% Ho-80% Tb exhibits two magnetic phases, similar to those of Tb. The spiral turn angle varies from 31.1° to 21.4°. A minimum effective spin for the occurrence of stable simple ferromagnetic structure at low temperatures is predicted....

  11. Addition of HO-nucleophiles to free and coordinated nitriles

    International Nuclear Information System (INIS)

    Bokach, Nadejda A; Kukushkin, Vadim Yu

    2005-01-01

    The review surveys data on the addition of HO-nucleophiles (water, oximes, hydroxylamines, hydroxamic acids, alcohols) to nitriles. Main methods for C≡N bond activation in nucleophilic addition reactions are discussed. Particular attention is given to activation of nitriles through coordination to metal centres.

  12. Near IR Photolysis of HO2NO2: Supplemental Material

    Science.gov (United States)

    2002-01-01

    MkIV measurements of the volume mixing ratio (VMR) of HO2NO2 at 35 deg N, sunset on Sept. 25, 1993 are given. Measurements of HO2NO2 made between approx. 65 and 70 deg N, sunrise on May 8, 1997 are listed. The uncertainties given are 1 sigma estimates of the measurement precision. Uncertainty in the HO2NO2 line strengths is estimated to be 20%; this is the dominant contribution to the systematic error of the HO2NO2 measurement. Model inputs for the simulations are given. The albedos were obtained from Total Ozone Mapping Spectrometer reflectively data (raw data at ftp://jwocky.gsfc.nasa.gov) for the time and place of observation. Profiles of sulfate aerosol surface area ("Surf. Area") were obtained from monthly, zonal mean profiles measured by SAGE II [Thomason et al., 1997 updated via private communication]. The profile of Be(y) is based on the Wamsley et al. relation with N2O, using MkIV measurements of N20O. All other model inputs given are based on direct MkIV measurements. Finally, we note the latitude of the MkIV tangent point varied considerably during sunrise on May 8, 1997. The simulations shown here were obtained using different latitudes for each altitude.

  13. Analysis of n+165Ho and 169Tm reactions

    International Nuclear Information System (INIS)

    Young, P.G.; Arthur, E.D.; Philis, C.; Nagel, P.; Collin, M.

    1982-09-01

    Experimental data for neutron-induced reactions on 165 Ho and 169 Tm have been theoretically analyzed in preparation for calculations on the unstable isotopes of Tm. A set of deformed optical model parameters was determined from measurements of s- and p-wave neutron strength functions, total cross sections, elastic angular distributions, and 16-MeV proton scattering to the 165 Ho ground and first excited states. The parameters for the 165 Ho and 169 Tm nuclei were linked by means of an isospin term in the real and imaginary well depths, together with adjustment of the ν 2 and ν 4 deformation parameters based on systematics in this mass region. Transmission coefficients from this analysis were used in Hauser-Feshbach statistical model calculations of the 169 Tm(n,ν) cross section as well as the 169 Tm(n,2n) and (n,3n) cross sections to 23 MeV, after application of suitable preequilibrium corrections. The results of these calculations are in good agreement with most of the available experimental data on 165 Ho and 169 Tm

  14. Preparation of sup 125 I-creatine phosphokinase-MM

    Energy Technology Data Exchange (ETDEWEB)

    Jingxian, Su; Jingmin, Ma [Academia Sinica, Beijing, BJ (China). Inst. of Atomic Energy

    1988-09-01

    {sup 125}I-creatine phosphokinase-MM ({sup 125}I-CPK-MM) was prepared by {sup 125}I-labelled Bolton-Hunter reagent (HPNS). Iodinating conditions of HPNS and its conjugation to protein were studied. {sup 125}I-CPK-MM with immune activity was obtained and used to establish the {sup 125}I-CPK-MM radioimmunoassay method by the General Hospital of PLA. {sup 125}I-CPK-MM in PBS-G solution containing 0.015 mol/l ethyl mercaptan at 4-10 deg C can be used for one month.

  15. CT-based postimplant dosimetry of prostate brachytherapy. Comparison of 1-mm and 5-mm section CT

    International Nuclear Information System (INIS)

    Tanaka, Osamu; Hayashi, Shinya; Kanematsu, Masayuki; Matsuo, Masayuki; Hoshi, Hiroaki; Nakano, Masahiro; Maeda, Sanaho; Deguchi, Takashi; Hoshi, Hiroaki

    2007-01-01

    The aim of this study was to compare the outcomes between 1-mm and 5-mm section computed tomography (CT)-based postimplant dosimetry. A series of 21 consecutive patients underwent permanent prostate brachytherapy. The postimplant prostate volume was calculated using 1-mm and 5-mm section CT. One radiation oncologist contoured the prostate on CT images to obtain the reconstructed prostate volume (pVol), prostate V 100 (percent of the prostate volume receiving at least the full prescribed dose), and prostate D 90 (mean dose delivered to 90% of the prostate gland). The same radiation oncologist performed the contouring three times to evaluate intraobserver variation and subjectively scored the quality of the CT images. The mean ±1 standard deviation (SD) postimplant pVol was 20.17±6.66 cc by 1-mm section CT and 22.24±8.48 cc by 5-mm section CT; the difference in the mean values was 2.06 cc (P 100 was 80.44%±7.06% by 1-mm section CT and 77.33%±10.22% by 5-mm section CT. The mean postimplant prostate D 90 was 83.28%±10.81% by 1-mm section CT and 78.60%±15.75% by 5-mm section CT. In the evaluation of image quality, 5-mm section CT was assigned significantly higher scores than 1-mm section CT. In regard to intraobserver variation, 5-mm section CT revealed less intraobserver variation than 1-mm section CT. Our current results suggested that the outcomes of postimplant dosimetry using 1-mm section CT did not improved the results over those obtained using 5-mm section CT in terms of the quality of the CT image or reproducibility. (author)

  16. The upconversion luminescence and magnetism in Yb3+/Ho3+ co-doped LaF3 nanocrystals for potential bimodal imaging

    Science.gov (United States)

    Syamchand, Sasidharanpillai S.; George, Sony

    2016-12-01

    Biocompatible upconversion nanoparticles with multifunctional properties can serve as potential nanoprobes for multimodal imaging. Herein, we report an upconversion nanocrystal based on lanthanum fluoride which is developed to address the imaging modalities, upconversion luminescence imaging and magnetic resonance imaging (MRI). Lanthanide ions (Yb3+ and Ho3+) doped LaF3 nanocrystals (LaF3 Yb3+/Ho3+) are fabricated through a rapid microwave-assisted synthesis. The hexagonal phase LaF3 nanocrystals exhibit nearly spherical morphology with average diameter of 9.8 nm. The inductively coupled plasma mass spectrometry (ICP-MS) analysis estimated the doping concentration of Yb3+ and Ho3+ as 3.99 and 0.41%, respectively. The nanocrystals show upconversion luminescence when irradiated with near-infrared (NIR) photons of wavelength 980 nm. The emission spectrum consists of bands centred at 542, 645 and 658 nm. The stronger green emission at 542 nm and the weak red emissions at 645 and 658 nm are assigned to 5S2 → 5I8 and 5F5 → 5I8 transitions of Ho3+, respectively. The pump power dependence of luminescence intensity confirmed the two-photon upconversion process. The nanocrystals exhibit paramagnetism due to the presence of lanthanide ion dopant Ho3+ and the magnetization is 19.81 emu/g at room temperature. The nanocrystals exhibit a longitudinal relaxivity ( r 1) of 0.12 s-1 mM-1 and transverse relaxivity ( r 2) of 28.18 s-1 mM-1, which makes the system suitable for developing T2 MRI contrast agents based on holmium. The LaF3 Yb3+/Ho3+ nanocrystals are surface modified by PEGylation to improve biocompatibility and enhance further functionalisation. The PEGylated nanocrystals are found to be non-toxic up to 50 μg/mL for 48 h of incubation, which is confirmed by the MTT assay as well as morphological studies in HeLa cells. The upconversion luminescence and magnetism together with biocompatibility enables the adaptability of the present system as a nanoprobe for potential

  17. Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy.

    Science.gov (United States)

    Wang, Qiongling; Quick, Ann P; Cao, Shuyi; Reynolds, Julia; Chiang, David Y; Beavers, David; Li, Na; Wang, Guoliang; Rodney, George G; Anderson, Mark E; Wehrens, Xander H T

    2018-04-01

    Duchenne muscular dystrophy patients are prone to ventricular arrhythmias, which may be caused by abnormal calcium (Ca 2+ ) homeostasis and elevated reactive oxygen species. CaMKII (Ca 2+ /calmodulin-dependent protein kinase II) is vital for normal Ca 2+ homeostasis, but excessive CaMKII activity contributes to abnormal Ca 2+ homeostasis and arrhythmias in cardiomyocytes. Reactive oxygen species induce CaMKII to become autonomously active. We hypothesized that genetic inhibition of CaMKII oxidation (ox-CaMKII) in a mouse model of Duchenne muscular dystrophy can alleviate abnormal Ca 2+ homeostasis, thus, preventing ventricular arrhythmia. The objective of this study was to test if selective loss of ox-CaMKII affects ventricular arrhythmias in the mdx mouse model of Duchenne muscular dystrophy. 5-(6)-Chloromethyl-2,7-dichlorodihydrofluorescein diacetate staining revealed increased reactive oxygen species production in ventricular myocytes isolated from mdx mice, which coincides with elevated ventricular ox-CaMKII demonstrated by Western blotting. Genetic inhibition of ox-CaMKII by knockin replacement of the regulatory domain methionines with valines (MM-VV [CaMKII M281/282V]) prevented ventricular tachycardia in mdx mice. Confocal calcium imaging of ventricular myocytes isolated from mdx :MM-VV mice revealed normalization of intracellular Ca 2+ release events compared with cardiomyocytes from mdx mice. Abnormal action potentials assessed by optical mapping in mdx mice were also alleviated by genetic inhibition of ox-CaMKII. Knockout of the NADPH oxidase regulatory subunit p47 phox normalized elevated ox-CaMKII, repaired intracellular Ca 2+ homeostasis, and rescued inducible ventricular arrhythmias in mdx mice. Inhibition of reactive oxygen species or ox-CaMKII protects against proarrhythmic intracellular Ca 2+ handling and prevents ventricular arrhythmia in a mouse model of Duchenne muscular dystrophy. © 2018 American Heart Association, Inc.

  18. OH, HO2, and HO2* Radical Chemistry During PROPHET-AMOS 2016: Measurements and Model Comparison

    Science.gov (United States)

    Bottorff, B.; Lew, M.; Rickly, P.; Stevens, P. S.

    2017-12-01

    The hydroxyl (OH) and peroxy radicals, both the hydroperoxy radical (HO2) and organic peroxy radicals (RO2), play an important role in atmospheric chemistry. In addition to controlling lifetimes of many trace gases important to issues of global climate change, reactions of these radicals can also lead to the production of ozone and secondary organic aerosols in the atmosphere. Previous measurements of these radicals in remote forest environments have shown serious discrepancies with modeled concentrations. These results bring into question our understanding of the atmospheric chemistry of isoprene and other biogenic VOCs under low NOX conditions. In the summer of 2016, OH, HO2 and HO2* (HO2 + αRO2) radicals were measured using the Indiana University Laser-Induced Fluorescence Fluorescence Assay by Gas Expansion (LIF-FAGE) technique as part of the Program for Research on Oxidants: PHtochemistry, Emissions, and Transport- Atmospheric Measurements of Oxidants in Summer (PROPHET-AMOS). This campaign took place in a forested area in northern Michigan characterized by high mixing ratios of isoprene and low mixing ratios of NOX. Ambient measurements from this campaign will be compared to previous measurements at this site and to modeled predictions using both the Regional Atmospheric Chemistry Mechanism (RACM2) and the Master Chemical Mechanism. Potential interferences associated with the OH measurements will also be examined.

  19. Odhady absolutního kardiovaskulárního rizika v České republice

    Czech Academy of Sciences Publication Activity Database

    Reissigová, Jindra; Zvárová, Jana

    2008-01-01

    Roč. 88, č. 5 (2008), s. 288-292 ISSN 0032-6739 Institutional research plan: CEZ:AV0Z10300504 Keywords : framinghamská studie * SCORE studie * odhad kardiovaskulárního rizika * validační studie Subject RIV: BB - Applied Statistics, Operational Research

  20. Dosimetric effectiveness in implants with distinct HO166-seed distribution in prostate

    International Nuclear Information System (INIS)

    Braga, Viviane V. B.; Campos, Tarcísio P. R.

    2017-01-01

    Currently, there is a need to produce new therapeutic techniques for the treatment of prostate tumors, considering the high incidence of the disease and significant morbidity rates associated with surgery and radiotherapy. Simulations in brachytherapy produce essential information about the efficiency and dosimetric efficacy compared to other techniques. Computational simulation by Monte Carlo method has been used to evaluate the absorbed dose and effective dose in radiotherapy and radiology. Virtual, analytical or voxelized phantoms are useful in the internal assessment of the spatial distribution of absorbed dose. This study estimated the efficiency of dosimetry by parameters of merit generated from volumetric distributions of absorbed doses simulating various spatial distributions of Ho-166 seeds in a prostate model. A computer model of voxels was developed, using the code SISCODES (Computational System for Dosimetry by Neutrons and Photons by Stochastic Methods applied to radiology and radiotherapy), representative of a real physical simulator predefined as a calibration method. The virtual model reproduced a cubic box, filled with muscle equivalent tissue (TE), where a 5-cm diameter ball with TE-prostate was positioned 2-cm from the air interface. A Ho-166 seed distribution, produced by 16 filet-implants distributed regularly (10-mm pitch) containing 04 separate 8-mm seeds, was employed. Two pitch were considered: 9 and 10 mm, with same distance between seed in a fillet. Based on SISCODE database of chemical composition of tissues and nuclear data, The code allowed the association of nuclear and chemical data to the voxels of the model, by the selection of the tissue of each voxel, as well as the positioning of the sources and their spatial distribution and spectra. The code MCNP5 simulated the transport of photons and electrons in the model, generating the energy deposited per unit mass in each voxel for photons in MeV.g-1 and energy absorbed in MeV for beta

  1. Dosimetric effectiveness in implants with distinct HO166-seed distribution in prostate

    Energy Technology Data Exchange (ETDEWEB)

    Braga, Viviane V. B.; Campos, Tarcísio P. R., E-mail: Vitoriabraga06@gmail.com, E-mail: tprcampos@yahoo.com.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear

    2017-07-01

    Currently, there is a need to produce new therapeutic techniques for the treatment of prostate tumors, considering the high incidence of the disease and significant morbidity rates associated with surgery and radiotherapy. Simulations in brachytherapy produce essential information about the efficiency and dosimetric efficacy compared to other techniques. Computational simulation by Monte Carlo method has been used to evaluate the absorbed dose and effective dose in radiotherapy and radiology. Virtual, analytical or voxelized phantoms are useful in the internal assessment of the spatial distribution of absorbed dose. This study estimated the efficiency of dosimetry by parameters of merit generated from volumetric distributions of absorbed doses simulating various spatial distributions of Ho-166 seeds in a prostate model. A computer model of voxels was developed, using the code SISCODES (Computational System for Dosimetry by Neutrons and Photons by Stochastic Methods applied to radiology and radiotherapy), representative of a real physical simulator predefined as a calibration method. The virtual model reproduced a cubic box, filled with muscle equivalent tissue (TE), where a 5-cm diameter ball with TE-prostate was positioned 2-cm from the air interface. A Ho-166 seed distribution, produced by 16 filet-implants distributed regularly (10-mm pitch) containing 04 separate 8-mm seeds, was employed. Two pitch were considered: 9 and 10 mm, with same distance between seed in a fillet. Based on SISCODE database of chemical composition of tissues and nuclear data, The code allowed the association of nuclear and chemical data to the voxels of the model, by the selection of the tissue of each voxel, as well as the positioning of the sources and their spatial distribution and spectra. The code MCNP5 simulated the transport of photons and electrons in the model, generating the energy deposited per unit mass in each voxel for photons in MeV.g-1 and energy absorbed in MeV for beta

  2. Isolation of {sup 163}Ho from dysprosium target material by HPLC for neutrino mass measurements

    Energy Technology Data Exchange (ETDEWEB)

    Mocko, Veronika; Taylor, Wayne A.; Nortier, Francois M.; Engle, Jonathan W.; Pollington, Anthony D.; Kunde, Gerd J.; Rabin, Michael W.; Birnbaum, Eva R. [Los Alamos National Laboratory, Los Alamos, NM (United States). Chemistry Div.; Barnhart, Todd E.; Nickles, Robert J. [Univ. Wisconsinn, Madison, WI (United States). Dept. of Medical Physics

    2015-07-01

    The rare earth isotope {sup 163}Ho is of interest for neutrino mass measurements. This report describes the isolation of {sup 163}Ho from a proton-irradiated dysprosium target and its purification. A Dy metal target was irradiated with 16 MeV protons for 10 h. After target dissolution, {sup 163}Ho was separated from the bulk Dy via cation-exchange high performance liquid chromatography using 70 mmol dm{sup -3} α-hydroxyisobutyric acid as the mobile phase. Subsequent purification of the collected Ho fraction was performed to remove the α-hydroxyisobutyrate chelating agent and to concentrate the Ho in a low ionic strength aqueous matrix. The final solution was characterized by MC-ICP-MS to determine the {sup 163}Ho/{sup 165}Ho ratio, {sup 163}Ho and the residual Dy content. The HPLC purification process resulted in a decontamination factor 1.4 x 10{sup 5} for Dy. The isolated Ho fraction contained 24.8 ± 1.3 ng of {sup 163}Ho corresponding to holmium recovery of 72 ± 3%.

  3. Comparing particles for radiosynovectomy labeled with Ho-166

    International Nuclear Information System (INIS)

    Argueelles, M.G.; Luppi Berlanga, I.S.; Torres, E.A.; Pereyra Molina, V.

    2002-01-01

    Aim: Three types of microparticles containing Ho-166 were investigated as potential agents for radiation synovectomy. These are: hydroxyapatite (HA), ferric hydroxide macro-aggregates (FHMA) and polymeric micro-spheres (PM). Labeling was performed by three different methods: coprecipitation, two steps labeling using citrate and irradiation of Ho-165 complexed to acetylacetone (AcAc) incorporated into poly-L-lactic acid spheres (PLA) by the solvent evaporation technique. Material and methods: a coprecipitation technique of holmium hydroxide and ferric hydroxide was used in order to obtain 166 Ho-FHMA. Particle size was determined by optical microscopy and selective filtration (1.2 - 100 μm). Obtainment efficiency of FHMA was always higher than 90%. Radiochemical purity was checked by thin layer chromatography using ITLC/SG and EDTA solution as solvent. In vitro stability studies were performed by incubating labelled particles in either saline, or EDTA solution. Hydroxyapatite particles were prepared from the reaction of calcium nitrate and ammonia phosphate at high pH. By strong heating of the precipitate at 800 0 C, the product becomes largely anhydrous and hardened. The yield of the hydroxyapatite synthesis was always greater than 80%. Particle size range was studied using light microscopy. Labeling was done in two steps: 166Ho-citrate was prepared by adding sufficient citric acid to the 166 Ho-Cl 3 solution. The radioactive solution was added to the particulate suspension stirring continuously. Radiolabelled particles were rinsed and separated by centrifugation. Stable Ho-165, complexed to acetylacetone (AcAc), was incorporated into PLA spheres by the solvent evaporation technique. The particle size distribution of the micro-spheres was determined by electronic microscopy. A X-ray fluorescence technique was used to determine the percentage of 165 Ho-AcAc incorporated in the microspheres by studying standards and prepared PLA spheres. Stability studies were

  4. Ho:YLF & Ho:LuLF slab amplifier system delivering 200 mJ, 2 µm single-frequency pulses

    CSIR Research Space (South Africa)

    Strauss, HJ

    2011-07-01

    Full Text Available A single-frequency single-pass amplifier based on Ho:YLF and Ho:LuLF in a scalable slab architecture delivering up to 210 mJ at 2064 nm is demonstrated. The amplifier was end-pumped by a 1890 nm Tm:YLF slab laser and was seeded with a 69 mJ single...

  5. Návrh slaďování pracovního a soukromého života ve vybrané organizaci

    OpenAIRE

    Majerčíková, Andrea

    2014-01-01

    Cílem diplomové práce je analyzovat strategii vybrané soukromé organizace v oblasti slaďování pracovního a osobního života a navrhnout opatření ke zlepšení stávajícího stavu. Práce specifikuje pojmy jako konflikt rolí v rámci pracovního a osobního života, gender a politika rovných příležitostí, koncept „flexicurity“ a dále nastiňuje různorodá opatření napomáhající slaďování pracovního a soukromého života. V rámci analýzy bylo využito dotazníkového šetření a rozhovoru s manažerkou vybrané orga...

  6. Selective separation of yttrium by CA-100 in the presence of a complexing agent

    International Nuclear Information System (INIS)

    Sun Xiaobo; Wang Yige; Li Deqian

    2006-01-01

    The selective separation of Y from yttrium solution containing small heavy rare earth (HRE) impurities (Ho, Er, Tm, Yb, Lu) by liquid-liquid extraction using CA-100 in the presence of a water-soluble complexing agent of ethylenediaminetetraacetic acid (EDTA) was experimentally studied at 298 K. Experiments were carried out in two feeds, Feed-I: [RE] f = 4.94 x 10 -3 M, Y = 98.5%, HRE (Ho, Er, Tm, Yb, Lu) = 1.5%; Feed-II: [RE] f = 4.94 x 10 -3 M, Y = 99.9%, HRE (Ho, Er, Tm, Yb, Lu) = 0.1%, as a function of equilibrium pH (pH eq ), the concentration ratio of [EDTA]:[HRE impurities]. It was shown that the extraction of HRE in the presence of EDTA was suppressed when compared to that of Y because of the masking effect, while the selective extraction of Y was enhanced and the separation factors increased to maximum at appropriate condition for Feed-I: Y/Ho = 1.53, Y/Er 3.09, Y/Tm = 5.61, Y/Yb = 12.04, Y/Lu = 27.51 at pH 4.37 and [EDTA]:[HRE impurities] = 4:1, for Feed-II: Y/Ho = 1.32, Y/Er = 1.91, Y/Tm = 2.00, Y/Yb 3.05, Y/Lu = 3.33 at pH 4.42 and [EDTA]:[HRE impurities] = 8:1. The separation and purification of Y by this method was discussed

  7. Optical characteristics of BaGa2S4:Ho3+ and BaGa2Se4:Ho3+ single crystals

    International Nuclear Information System (INIS)

    Choe, Sung-Hyu; Jin, Moon-Seog; Kim, Wha-Tek

    2005-01-01

    BaGa 2 S 4 , BaGa 2 S 4 :Ho 3+ , BaGa 2 Se 4 , and BaGa 2 Se 4 :Ho 3+ single crystals were grown by using the chemical transport reaction method. The optical energy gaps of the single crystals were investigated in the temperature region from 11 K to 300 K. The temperature dependence of the optical energy gap was well fitted by the Varshni equation. Two broad emission bands were observed in the photoluminescence spectra of the single crystals. These bands were attributed to donor-acceptor pair recombinations. Sharp emission peaks were observed in the BaGa 2 S 4 :Ho 3+ and the BaGa 2 Se 4 :Ho 3+ single crystals and were assigned to radiation recombination between split Stark levels of Ho 3+ .

  8. Mapping Ground Subsidence Phenomena in Ho Chi Minh City through the Radar Interferometry Technique Using ALOS PALSAR Data

    Directory of Open Access Journals (Sweden)

    Dinh Ho Tong Minh

    2015-07-01

    Full Text Available The rapidly developing urbanization since the last decade of the 20th century has led to extensive groundwater extraction, resulting in subsidence in Ho Chi Minh City, Vietnam. Recent advances in multi-temporal spaceborne SAR interferometry, especially with a persistent scatters interferometry (PSI approach, has made this a robust remote sensing technique for measuring large-scale ground subsidence with millimetric accuracy. This work has presented an advanced PSI analysis, to provide an unprecedented spatial extent and continuous temporal coverage of the subsidence in Ho Chi Minh City from 2006 to 2010. The study shows that subsidence is most severe in the Holocene silt loam areas along the Sai Gon River and in the southwest of the city. The groundwater extraction resulting from urbanization and urban growth is mainly responsible for the subsidence. Subsidence in turn leads to more flooding and water nuisance. The correlation between the reference leveling velocity and the estimated PSI result is R2 = 0.88, and the root mean square error is 4.3 (mm/year, confirming their good agreement. From 2006 to 2010, the estimation of the average subsidence rate is -8.0 mm/year, with the maximum value up to -70 mm/year. After four years, in regions along Sai Gon River and in the southwest of the city, the land has sunk up to -12 cm. If not addressed, subsidence leads to the increase of inundation, both in frequency and spatial extent. Finally, regarding climate change, the effects of subsidence should be considered as appreciably greater than those resulting from rising sea level. It is essential to consider these two factors, because the city is inhabited by more than 7.5 million people, where subsidence directly impacts urban structures and infrastructure.

  9. Modification of Hack Saw Blade Support 'REMOR 400' from the Length of 650 mm to 450 mm

    International Nuclear Information System (INIS)

    Sagino, Abdul-Hafid

    2005-01-01

    REMOR 400 type is the hack saw machine for cutting large work piece. The capacity of cutting is 310 mm diameter. The length of the blade is 650 mm (26 inches). For cutting small work piece (≤ 150 mm), the use of this blade is not efficient because the blade is relatively expensive. To solve this problem, the modification of the blade support is performed so that REMOR 400 machine can use the blade of 450 mm which is cheaper and easier to find in the market. (author)

  10. Improving Student Understanding of Magmatic Differentiation Using an M&M Magma Chamber

    Science.gov (United States)

    Wirth, K. R.

    2003-12-01

    Many students, especially those in introductory geology courses, have difficulty developing a deep understanding of the processes of magmatic differentiation. In particular, students often struggle to understand Bowen's reaction series and fractional crystallization. The process of fractional crystallization by gravity settling can be illustrated using a model magma chamber consisting of M&M's. In this model, each major cation (e.g., Si, Ti, Al, Fe, Mg, Ca, Na, K) is represented by a different color M&M; other kinds of differently colored or shaped pieces could also be used. Appropriate numbers of each color M&M are combined to approximate the cation proportions of a basaltic magma. Students then fractionate the magma by moving M&M's to the bottom of the magma chamber forming a series of cumulus layers; the M&M's are removed in the stoichiometric proportions of cations in the crystallizing minerals (e.g., olivine, pyroxene, feldspars, quartz, magnetite, ilmenite). Students observe the changing cation composition (proportions of colors of M&M's) in the cumulus layers and in the magma chamber and graph the results using spreadsheet software. More advanced students (e.g., petrology course) can classify the cumulates and resulting liquid after each crystallization step, and they can compare the model system with natural magmatic systems (e.g., absence of important fractionating phases, volatiles). Students who have completed this exercise generally indicate a positive experience and demonstrate increased understanding of Bowen's reaction series and fractionation processes. They also exhibit greater familiarity with mineral stoichiometry, classification, solid-solution in minerals, element behavior (e.g., incompatibility), and chemical variation diagrams. Other models (e.g., paths of equilibrium and fractional crystallization on phase diagrams) can also be used to illustrate differentiation processes in upper level courses (e.g., mineralogy and petrology).

  11. Upconversion dynamics in Yb3+-Ho3+-doped fluoroindate glasses

    International Nuclear Information System (INIS)

    Martin, I.R.; Rodriguez, V.D.; Lavin, V.; Rodriguez-Mendoza, U.R.

    1998-01-01

    The mechanisms and dynamics of the upconversion emissions in Yb 3+ -Ho 3+ -doped fluoroindate glasses by exciting at 975 nm have been analysed. The upconversion efficiencies have been measured as a function of temperature in the range from 12 to 295 K. The temporal evolution of the 545- and 650-nm upconversion emissions obtained under flash excitation at 975 nm in codoped samples with 2.25 mol.% of Yb 3+ and 0.75 mol.% of Ho 3+ cannot be described using the energy migration model. This indicates that at this concentration of Yb 3+ the rapid migration regimen between these ions has not been reached. A model is proposed in order to explain the temporal evolution of these emissions taking into account energy migration between donors and backtransfer processes. (orig.)

  12. Atividade antimicrobiana e antioxidante do óleo essencial de ho-sho (Cinnamomum camphora Ness e Eberm Var. Linaloolifera fujita Antimicrobial and antioxidant activities of ho-sho (Cinnamomum camphora Ness e Eberm Var. Linaloolifera fujita essential oil

    Directory of Open Access Journals (Sweden)

    Rogério Luis Cansian

    2010-06-01

    Full Text Available Este trabalho teve como objetivo determinar a atividade antimicrobiana e antioxidante do óleo essencial de Ho-Sho. O principal componente do óleo essencial obtido a partir de folhas da planta submetidas ao processo de hidrodestilação foi o linalol (80 a 95% m/m. O óleo essencial mostrou atividade antimicrobiana para todos os microrganismos testados, com exceção de Pseudomonas aeruginosa. A maior atividade antimicrobiana do óleo essencial sobre as bactérias testadas foi observada sobre Xanthomonas campestris (33,0 mm e a menor sobre Yersinia enterocolitica (10,5 mm. Para a concentração inibitória mínima (CIM, observou-se que todos os microrganismos apresentaram-se susceptíveis ao óleo essencial de Ho-Sho. A variação das CIM para as bactérias Gram-positivas foi de 1,00 mg.mL-1 (Streptococcus mutans a 1,75 mg.mL-1 (Staphylococcus epidermidis. Já a variação das CIM para as bactérias Gram-negativas foi de 0,625 mg.mL-1 (Citrobacter freundii a 2,50 mg.mL-1 (Shigella flexneri. Os resultados obtidos na determinação da atividade antioxidante do óleo essencial demonstram que o percentual antioxidante aumenta proporcionalmente à concentração de óleo essencial adicionado, atingindo o valor máximo de 97,49% de atividade antioxidante para a concentração de 50000 μg.mL-1.The main objective of this work was to evaluate the antimicrobial and antioxidant activities of the Ho-Sho essential oil. The major component of the essential oil obtained from the leaves submitted to hydro-distillation was linalool (80-95 wt%. The essential oil showed antimicrobial activity for all tested microorganisms, except for Pseudomonas aeruginosa. Higher antimicrobial activities over the tested bacterium were observed for Xanthomonas campestris (33.0 mm, and lower activities were obtained for Yersinia enterocolitica (10.5 mm. For the minimal inhibition concentration (MIC, it was observed that all microorganisms presented susceptibility to the Ho

  13. Polarized neutron capture in polarized 59Co and 165Ho nuclei

    International Nuclear Information System (INIS)

    Bosman, J.J.

    1976-01-01

    Gamma spectroscopy on the reactions 59 Co(n,γ) 60 Co and 165 Ho(n,γ) 166 Ho with polarized neutrons and polarized targets enabled the assignment of spins to 36 levels in 60 Co and 15 levels in 166 Ho. Several of them had not been reported earlier. The techniques used to polarize neutron beams and targets and the gamma-spectroscopy are extensively discussed

  14. Spectroscopic analysis of LiHoF4 and LiErF4

    DEFF Research Database (Denmark)

    Christensen, H.P.

    1979-01-01

    The polarized absorption spectra for Ho3+ and Er3+ in LiHoF4 and LiErF4, respectively, have been recorded in the spectral interval 4000-26 000 cm-1 at 2 K. Parts of the spectra were examined at higher temperatures. The experimental levels for Ho3+ and Er3+ in LiRF4 were close to those found in Li...

  15. HoTbTi2O7, the mixtures of spin ice and spin liquid

    International Nuclear Information System (INIS)

    Chang, L.J.; Terashita, H.; Schweika, W.; Chen, Y.Y.; Gardner, J.S.

    2007-01-01

    Polycrystalline samples of Ho 2- x Tb x Ti 2 O 7 (x=0.5, 1, and 1.5) have been prepared and characterized. No long-range order is observed for HoTbTi 2 O 7 in magnetization and specific heat measurements down to 2 K. The low-energy magnetic excitation measurements suggests that HoTbTi 2 O 7 possesses both characteristics of spin ice and spin liquid in the ground state

  16. Insights into the photochemical transformation pathways of triclosan and 2′-HO-BDE-28

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Ya-nan; Xie, Qing; Chen, Jingwen, E-mail: jwchen@dlut.edu.cn; Li, Yingjie; Fu, Zhiqiang

    2015-12-30

    Highlights: • Direct photolysis of anionic HO-PXDEs occurs through excited singlet states. • Dioxin products are formed from excited singlet states of HO-PXDEs. • Self-sensitized photolysis is involved in the phototransformation of HO-PXDEs. • {sup 1} O{sub 2} and ·OH can be generated in energy or electron transfer reactions between excited HO-PXDEs and dissolved O{sub 2}. - Abstract: Hydroxylated polyhalogenated diphenyl ethers (HO-PXDEs) have been recognized as a group of widely detected emerging contaminants in natural waters. Photolysis was proved to be an important transformation pathway for these compounds and their direct phototransformation results in highly toxic dioxins. However, the roles of excited states and reactive oxygen species in the photochemical transformation of these compounds are still unclear. In this study, 2′-HO-2,4,4′-trichlorodiphenyl ether (triclosan) and 2′-HO-2,4,4′-tribromodiphenyl ether (2′-HO-BDE-28) were selected as model compounds to investigate their phototransformation processes. Results showed that the direct photolysis reactions of both triclosan and 2′-HO-BDE-28 occurred via their respective excited singlet states, leading to the generation of dioxins. In addition, the energy and electron transfer reactions between excited states of model compounds and molecular O{sub 2} can lead to the generation of {sup 1}O{sub 2} and ·OH, which results in self-sensitized photolysis. We also found that both the k, Φ dioxin yield for anionic triclosan were higher than those of anionic 2′-HO-BDE-28. This study revealed the roles of the excited states in direct photolysis and the generation pathway of reactive oxygen species in self-sensitized photolysis of HO-PXDEs, which is important for understanding the phototransformation mechanisms of HO-PXDEs.

  17. Consumer Behaviour. Case: iPhone Ho Chi Minh City

    OpenAIRE

    Tran, Thi Xuan Oanh

    2016-01-01

    The main aim of this thesis is to figure out the factors that have influenced consumer behaviour of young iPhone users in Ho Chi Minh City. In this study, the author draw a conclusion based on the data collected from the survey and proposed some feasible recommendations for Apple and other high-end smartphone companies to understand their consumers and enhance brand equity. For the secondary data, a variety of theories, including consumers’ characteristics, promotion and the decision mak...

  18. Identical gamma-vibrational bands in {sup 165}Ho

    Energy Technology Data Exchange (ETDEWEB)

    Radford, D.C.; Galindo-Uribarri, A.; Janzen, V.P. [Chalk River Labs., Ontario (Canada)] [and others

    1996-12-31

    The structure of {sup 165}Ho at moderate spins has been investigated by means of Coulomb excitation. Two {gamma}-vibrational bands (K{sup {pi}} = 11/2{sup {minus}} and K{sup {pi}} = 3/2{sup {minus}}) are observed, with very nearly identical in-band {gamma}-ray energies. Gamma-ray branching ratios are analyzed to extract information on Coriolis mixing, and the role of the K quantum number in identical bands is discussed.

  19. Temperature Variation of the Magnetic Structure of HoSb

    DEFF Research Database (Denmark)

    Andersen, Nils Axel; Kjems, Jørgen; Vogt, O.

    1980-01-01

    Neutron diffraction has been used to show that the magnetic moment vector in the antiferromagnet HoSb changes direction as a function of temperature below TN=5.7K. The experimental results are in qualitative agreement with a recent theoretical prediction by Jensen et al. (1980) which ascribe the ...... the changing directions to a competition between the crystal fields and the dipolar interactions....

  20. Spectroscopic characterization of Ho3+ ion-doped fluoride glass

    International Nuclear Information System (INIS)

    Florez, A.; Oliveira, S.L.; Florez, M.; Gomez, L.A.; Nunes, L.A.O.

    2006-01-01

    Among the new optical materials available, fluoride glass, which has an extended transmission window, is emerging as an important material for use in optical fibers, lasers, sensors, etc. Here, we analyze the spectroscopic properties of Ho 3+ ions in a fluoroindate glass based on absorption measurements. Ho 3+ -doped fluoroindate glass with the composition (40 - x)InF 3 -20SrF 2 -20ZnF 2 -16BaF 2 -2GdF 3 -2NaF-xHoF 3 , x = 1.0, 2.0, 2.5, 3.0, 4.0, 5.0, 6.0, 8.0 and 9.0 mol%, was prepared under an argon atmosphere. Absorption spectra in the range 300-2200 nm were then obtained. The experimental oscillator strength f Exp. was calculated from the areas under absorption bands. Using Judd-Ofelt theory and least-squares fitting, the phenomenological intensity parameter Ω λ (λ = 2, 4, 6) and the theoretical oscillator strength f Cal. were calculated. To evaluate potential applications and to analyze the properties of Ho 3+ ions in these host glasses, the following spectroscopy parameters were calculated: the transition probability between multiplets A JJ' , the branching ratio β JJ' , the radiative lifetime τ R , the peak cross-section for stimulated emission σ p , and the emitting-level multiphonon rate W NR for each band. The results were compared with those reported in the literature for similar glasses of the same concentration

  1. Phases, lattice parameters and thermal expansion of HoNi5-xAlx, 3≥x≥0

    International Nuclear Information System (INIS)

    Grzeta, B.; Sorgic, B.; Blazina, Z.

    1998-01-01

    The phases, lattice parameters and linear coefficient of thermal expansion were determined by X-ray powder diffraction between room temperature and 873 K for the system HoNi 5-x Al x (3 ≥ x ≥ 0). Alloys were hexagonal, in the space group P6/mmm; for 2 ≥ x ≥ 0 they were isostructural with CaCu 5 , and for 3 ≥ x ≥ 2 they were isostructural with YCo 3 Ga 2 . In both cases, the unit-cell parameters a and c increased as the Al content increased. The linear thermal expansion coefficient was composition dependent. Each of the investigated alloys exhibited an anisotropy in thermal expansion, the linear expansion coefficient along the a axis being larger than along the c axis. (orig.)

  2. Separation and implantation of the rare isotope {sup 163}Ho

    Energy Technology Data Exchange (ETDEWEB)

    Kieck, Tom; Chrysalidis, Katerina; Dorrer, Holger; Kormannshaus, Stefan; Schmidt, Sebastian; Schneider, Fabian; Wendt, Klaus [JGU Mainz (Germany); Duellmann, Christoph [JGU Mainz (Germany); GSI Darmstadt (Germany); Gamer, Lisa; Gastaldo, Loredana [Universitaet Heidelberg (Germany); Collaboration: ECHo-Collaboration

    2016-07-01

    The ECHo collaboration aims at measuring the electron neutrino mass by recording the spectrum following electron capture of {sup 163}Ho. To reach a sub-eV sensitivity, a large number of individual microcalorimeters is needed, into which the isotope must be implanted in a well-controlled manner. The necessary amount of {sup 163}Ho is produced by neutron irradiation of enriched {sup 162}Er in the ILL high flux reactor. This introduces significant contaminations of other radioisotopes, which have to be quantitatively removed both, by chemical and mass spectrometric separation. The application of resonance ionization at the RISIKO mass separator guarantees the required isotope selectivity for purification and suitable energy for ion implantation. The efficiency and stability of the laser ion source was improved by Finite-Element Analysis of the thermal processes. For optimum implantation into the detector pixels (170 x 170 μm{sup 2}) with minimum losses a small ion beam spot at the implantation site is needed. For this purpose, post focusing ion optics were installed. Simulations were performed in order to optimize the homogeneous distribution of the implanted ions. The necessity to alternate implantation phases with deposition of a thin metallic layer for {sup 163}Ho activities larger than 10 Bq is being discussed.

  3. Automatizace domácího mikropivovaru

    OpenAIRE

    Širůček, Pavel

    2015-01-01

    Práce pojednává o základech technologie výroby piva a surovinách pro výrobu piva potřebných, domácích mikropivovarech, základních postupech a principech užívaných v těchto pivovarech a jejich použití. Dále se věnuje konkrétnímu řešení zvoleného mikropivovaru, jeho návrhu, sestavení a automatizaci, včetně popisu řídícího softwaru. Zvolený mikropivovar je troj nádobový, k ohřevu je použit plynový hořák a přečerpávání zajišťuje čerpadlo. Jako řídící jednotka slouží programovatelný automat PLC LO...

  4. Návrh a implementace internetového obchodu

    OpenAIRE

    Maťák, Lubomír

    2010-01-01

    Obsahem této práce je analýza a návrh elektronického obchodu pro firmu, zabývající se velkoobchodním prodejem elektromateriálu a poskytování služeb v oblasti dodávek elektromateriálu na stavbu různých projektů, jak ze státního, tak ze soukromého sektoru. Nejedná se o klasický internetový obchod formou B2C. Koncept této práce je navržen jako B2B. Hlavní myšlenkou je online komunikace dodavatele a odběratele a možná kontrola, jak stavu zakázky, tak stavu skladu pro případné další objednávky. ...

  5. Fluctuations in a Hořava-Lifshitz bouncing cosmology

    International Nuclear Information System (INIS)

    Gao, Xian; Wang, Yi; Xue, Wei; Brandenberger, Robert

    2010-01-01

    Hořava-Lifshitz gravity is a potentially UV complete theory with important implications for the very early universe. In particular, in the presence of spatial curvature it is possible to obtain a non-singular bouncing cosmology. The bounce is realized as a consequence of higher order spatial curvature terms in the gravitational action. Here, we extend the study of linear cosmological perturbations in Hořava-Lifshitz gravity coupled to matter in the case when spatial curvature is present. As in the case without spatial curvature, we find that there is no extra dynamical degree of freedom for scalar metric perturbations. We study the evolution of fluctuations through the bounce and show that the solutions remain non-singular throughout. If we start with quantum vacuum fluctuations on sub-Hubble scales in the contracting phase, and if the contracting phase is dominated by pressure-less matter, then for λ = 1 and in the infrared limit the perturbations at late times are scale invariant. Thus, Hořava-Lifshitz gravity can provide a realization of the ''matter bounce'' scenario of structure formation

  6. Ca isotopes in refractory inclusions

    International Nuclear Information System (INIS)

    Niederer, F.R.; Papanastassiou, D.A.

    1984-01-01

    We report measurements of the absolute isotope abundance of Ca in Ca-Al-rich inclusions from the Allende and Leoville meteorites. Improved high precision measurements are reported also for 46 Ca. We find that nonlinear isotope effects in Ca are extremely rare in these inclusions. The absence of nonlinear effects in Ca, except for the effects in FUN inclusions, is in sharp contrast to the endemic effects in Ti. One fine-grained inclusion shows an excess of 46 Ca of (7 +- 1) per mille, which is consistent with addition of only 46 Ca or of an exotic (*) component with 46 Ca* approx. 48 Ca*. FUN inclusion EK-1-4-1 shows a small 46 Ca excess of (3.3 +- 1.0) per mille; this confirms that the exotic Ca components in EK-1-4-1 were even more deficient in 46 Ca relative to 48 Ca than is the case for normal Ca. The Ca in the Ca-Al-rich inclusions shows mass dependent isotope fractionation effects which have a range from -3.8 to +6.7 per mille per mass unit difference. This range is a factor of 20 wider than the range previously established for bulk meteorites and for terrestrial and lunar samples. Ca and Mg isotope fractionation effects in the Ca-Al-rich inclusions are common and attributed to kinetic isotope effects. (author)

  7. Model elektronického obchodu pro služby

    OpenAIRE

    Zechmeisterová, Věra

    2009-01-01

    Obsahem práce je vytvoření modelu informačního zabezpečení služeb autoopravny a vytvoření odpovídajícího systémového řešení elektronického obchodování této autoopravny. The content of this Master thesis is the creation of the car repair shop services informational security model and also the creation of commensurate e-commerce system solution for this car repair shop. A

  8. Diode-Pumped Thulium (Tm)/Holmium (Ho) Composite Fiber 2.1-Micrometers Laser

    Science.gov (United States)

    2015-09-01

    Schematic of the 800-nm diode pumped Tm/Ho composite fiber laser 8 Under quasi-continuous wave (Q- CW ) pumping conditions of 1-ms duration and a...Fig. 9 (Top) Schematic of the 800-nm diode -pumped Tm/Ho composite fiber laser with outcoupler. (Left) Q- CW laser performance of the Tm/Ho composite...ARL-TR-7452 ● SEP 2015 US Army Research Laboratory Diode -Pumped Thulium (Tm)/Holmium (Ho) Composite Fiber 2.1-μm Laser by G

  9. The mass of the electron neutrino and electron capture in 163Ho

    International Nuclear Information System (INIS)

    Yasumi, S.; Rajasekaran, G.; Ando, M.; Ochiai, F.; Ikeda, H.; Ohta, T.; Stefan, P.M.; Maruyama, M.; Nashimoto, N.; Fujioka, M.; Ishii, K.; Shinozuka, T.; Sera, K.; Omori, T.; Izawa, G.; Yagi, M.; Masumoto, K.; Shima, K.

    1983-01-01

    To determine the mass of the electron neutrino, electron capture in 163 Ho was studied. From the intensity of M X-rays and the total number of 163 Ho atoms in a source, as determined by the PIXE method, the partial M-capture half life of 163 Ho was estimated to be (4.5 +- 1.5) x 10 4 yr. A relation between the Q-value of 163 Ho and the mass of the electron neutrino was obtained. (orig.)

  10. [hHO-1 structure prediction and its mutant construct, expression, purification and activity analysis].

    Science.gov (United States)

    Xia, Zhen Wei; Cui, Wen Jun; Zhou, Wen Pu; Zhang, Xue Hong; Shen, Qing Xiang; Li, Yun Zhu; Yu, Shan Chang

    2004-10-01

    Human Heme Oxygenase-1 (hHO-1) is the rate-limiting enzyme in the catabolism reaction of heme, which directly regulates the concentration of bilirubin in human body. The mutant structure was simulated by Swiss-pdbviewer procedure, which showed that the structure of active pocket was changed distinctly after Ala25 substituted for His25 in active domain, but the mutated enzyme still binded with heme. On the basis of the results, the expression vectors, pBHO-1 and pBHO-1(M), were constructed, induced by IPTG and expressed in E. coli DH5alpha strain. The expression products were purified with 30%-60% saturation (NH4)2SO4 and Q-Sepharose Fast Flow column chromatography. The concentration of hHO-1 in 30%-60% saturation (NH4)2SO4 components and in fractions through twice column chromatography was 3.6-fold and 30-fold higher than that in initial product, respectively. The activity of wild hHO-1 (whHO-1) and mutant hHO-1 (deltahHO-1) showed that the activity of deltahHO-1 was reduced 91.21% compared with that of whHO-1. The study shows that His25 is of importance for the mechanism of hHO-1, and provides the possibility for effectively regulating the activity to exert biological function.

  11. Konstrukce nosného rámu pro satelitní anténu

    OpenAIRE

    Hrdonka, Štěpán

    2016-01-01

    Cílem bakalářské práce je konstrukční návrh nosného rámu pro satelitní anténu. Nosný rám umožní montáž satelitu na osobní automobil. Součástí řešení je i návrh rotačního uložení, které umožní rotaci paraboly kolem vertikální osy. Konstrukční řešení rámu je navrhnuto tak, aby bylo schopné odolávat požadovanému zatížení větru a jeho průhyb zásadně neovlivňoval kvalitu signálu. Pevnostní analýza byla provedena pomocí metody konečných prvků. Výsledný maximální průhyb vyšel 1,6 mm při působení vel...

  12. Texture development due to preferential grain growth of Ho--Ba--Cu--O in 1.6-T magnetic field

    International Nuclear Information System (INIS)

    Holloway, A.; McCallum, R.W.; Arrasmith, S.R.

    1993-01-01

    It has been experimentally observed that the application of even a relatively weak magnetic field of 1.6-T during sintering of HoBa 2 Cu 3 O 7-δ (hereafter HoBCO) results in a significant degree of grain alignment. The orientation of grains is found to be controlled by the direction and magnitude of a magnetic field. The degree of alignment was monitored by x-ray diffraction measurements on the flat surface of the samples and by metallography. It has been observed that the degree of alignment grows as the magnitude of the field increases between 0 and 1.6 T for a fixed temperature and processing time. The degree of alignment also increases when the processing temperature changes from 930 degree C to 965 degree C for a fixed field and time. It has also been observed that for both a fixed field and processing temperature, the alignment grows when the processing time increases between 16 and 72 hours. Metallography measurements on the flat and cross-sectional parts of the samples showed that the texture propagates into the bulk of the samples. In the presence of a sufficient amount of the liquid phase, the enhancement of the grain growth in the direction favorable to the magnetic field produces rather large single-crystals (0.3 to 0.5 mm linear size) within the sample

  13. Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes.

    Directory of Open Access Journals (Sweden)

    Cristina I López Sanjurjo

    Full Text Available Inositol 1,4,5-trisphosphate (IP3 evokes release of Ca2+ from the endoplasmic reticulum (ER, but the resulting Ca2+ signals are shaped by interactions with additional intracellular organelles. Bafilomycin A1, which prevents lysosomal Ca2+ uptake by inhibiting H+ pumping into lysosomes, increased the amplitude of the initial Ca2+ signals evoked by carbachol in human embryonic kidney (HEK cells. Carbachol alone and carbachol in combination with parathyroid hormone (PTH evoke Ca2+ release from distinct IP3-sensitive Ca2+ stores in HEK cells stably expressing human type 1 PTH receptors. Bafilomycin A1 similarly exaggerated the Ca2+ signals evoked by carbachol or carbachol with PTH, indicating that Ca2+ released from distinct IP3-sensitive Ca2+ stores is sequestered by lysosomes. The Ca2+ signals resulting from store-operated Ca2+ entry, whether evoked by thapsigargin or carbachol, were unaffected by bafilomycin A1. Using Gd3+ (1 mM to inhibit both Ca2+ entry and Ca2+ extrusion, HEK cells were repetitively stimulated with carbachol to assess the effectiveness of Ca2+ recycling to the ER after IP3-evoked Ca2+ release. Blocking lysosomal Ca2+ uptake with bafilomycin A1 increased the amplitude of each carbachol-evoked Ca2+ signal without affecting the rate of Ca2+ recycling to the ER. This suggests that Ca2+ accumulated by lysosomes is rapidly returned to the ER. We conclude that lysosomes rapidly, reversibly and selectively accumulate the Ca2+ released by IP3 receptors residing within distinct Ca2+ stores, but not the Ca2+ entering cells via receptor-regulated, store-operated Ca2+ entry pathways.

  14. Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes.

    Science.gov (United States)

    López Sanjurjo, Cristina I; Tovey, Stephen C; Taylor, Colin W

    2014-01-01

    Inositol 1,4,5-trisphosphate (IP3) evokes release of Ca2+ from the endoplasmic reticulum (ER), but the resulting Ca2+ signals are shaped by interactions with additional intracellular organelles. Bafilomycin A1, which prevents lysosomal Ca2+ uptake by inhibiting H+ pumping into lysosomes, increased the amplitude of the initial Ca2+ signals evoked by carbachol in human embryonic kidney (HEK) cells. Carbachol alone and carbachol in combination with parathyroid hormone (PTH) evoke Ca2+ release from distinct IP3-sensitive Ca2+ stores in HEK cells stably expressing human type 1 PTH receptors. Bafilomycin A1 similarly exaggerated the Ca2+ signals evoked by carbachol or carbachol with PTH, indicating that Ca2+ released from distinct IP3-sensitive Ca2+ stores is sequestered by lysosomes. The Ca2+ signals resulting from store-operated Ca2+ entry, whether evoked by thapsigargin or carbachol, were unaffected by bafilomycin A1. Using Gd3+ (1 mM) to inhibit both Ca2+ entry and Ca2+ extrusion, HEK cells were repetitively stimulated with carbachol to assess the effectiveness of Ca2+ recycling to the ER after IP3-evoked Ca2+ release. Blocking lysosomal Ca2+ uptake with bafilomycin A1 increased the amplitude of each carbachol-evoked Ca2+ signal without affecting the rate of Ca2+ recycling to the ER. This suggests that Ca2+ accumulated by lysosomes is rapidly returned to the ER. We conclude that lysosomes rapidly, reversibly and selectively accumulate the Ca2+ released by IP3 receptors residing within distinct Ca2+ stores, but not the Ca2+ entering cells via receptor-regulated, store-operated Ca2+ entry pathways.

  15. CW and AO Q-switched operation of a dual-crystal Tm, Ho:GdVO4 laser pumped by two diodes

    International Nuclear Information System (INIS)

    Li, L J; Bai, Y F; Liu, Y W; He, Z L; Wang, J; Yao, B Q; Zhou, S; Xing, M N

    2013-01-01

    Continuous wave (CW) mode and acousto-optic (AO) Q-switched mode operation of a dual-crystal Tm, Ho:GdVO 4 laser is reported. The dual-crystal Tm, Ho:GdVO 4 laser with output wavelength of 2.05 μm was pumped by two laser diodes (LDs). The Tm, Ho:GdVO 4 crystals were cooled by liquid nitrogen and pumped by two fiber-coupled LDs with a center output wavelength of 801.0 nm. A 20.5 W output power was obtained at a 255 mm physical cavity length in CW mode operation, and a 19.6 W average power was obtained at a pulse repetition frequency (PRF) of 10 kHz with a 19 ns pulse duration. Also, the efficiency loss of the laser is not more than 4.4% from CW mode to Q-switch mode, and the M 2 factor, which is measured by the traveling knife-edge method, does not exceed 1.2. (paper)

  16. The effect of Ho to the flux pinning and microstructure of powder melting process Y(Ho)BCO samples

    International Nuclear Information System (INIS)

    Liu Peng; Chao Xixu; Shi Zhiqiang; Zhao Zhongxiang

    1994-01-01

    Magnetic relaxation and magnetization are measured for powder melting Y 1-x Ho x Ba 2 Cu 3 O 7 (x = 0.2, 0.4, and 0.6) samples within a wide temperature range. The pinning potential U and magnetization critical current densities J c are obtained according to the theory of Anderson and Kim and Bean's model. It is found that both U and J c are a affected by the addition of the rare-earth element Ho. In the sample with x = 0.4 the pinning potential U and the critical current J c have maximum values when the magnetic field is parallel to the c-axis. An unusual behaviour of U as a function of temperature T, which may be related to the pinning potential distribution in the sample is observed. (orig.)

  17. Fine Structure in Proton Emission from the Deformed 141g.sHo and 141mHo

    International Nuclear Information System (INIS)

    Karny, M.; Rykaczewski, Krzysztof Piotr; Grzywacz, R.; Batchelder, J.C.; Bingham, C.R.; Goodin, C. T.; Gross, Carl J.; Hamilton, J.H.; Korgul, A.; Krolas, W.; Liddick, S. N.; Li, K.; Maier, Karl; Mazzocchi, C.; Piechaczek, A.; Shapira, Dan; Simpson, D.; Tantawy, M.N.; Winger, J.A.; Yu, Chang-Hong; Zganjar, E. F.

    2007-01-01

    Fine structure in proton emission from the deformed states 141g.s Ho (T 1/2 = 4.1 ms) and 141 mHo (T 1/2 = 7.4 (micro)s) has been discovered at Oak Ridge by detecting fusion evaporation residues with the Recoil Mass Spectrometer, Si-detectors and digital signal processing electronics. The branching ratios to the first 2 + excited state in 140 Dy were measured to be I p g.s. (2 + ) = 0.9±0.1% and I p m (2 + ) = 1.7±0.5%. A comparison of the available calculations to the experimental values calls for further development of the theoretical models

  18. Návrh podnikatelského plánu pro vznik a rozvoj vybraného podniku

    OpenAIRE

    Kropáček, Lukáš

    2014-01-01

    Hlavním cílem předkládané absolventské práce je vytvořit návrh podnikatelského záměru pro vznik a další rozvoj minipivovaru. The main goal of the thesis is to propose a business plan for establishment and development of a microbrewery. A

  19. Initial results from 50mm short SSC dipoles at Fermilab

    International Nuclear Information System (INIS)

    Bossert, R.C.; Brandt, J.S.; Carson, J.A.; Coulter, K.; Delchamps, S.; Ewald, K.D.; Fulton, H.; Gonczy, I.; Gourlay, S.A.; Jaffery, T.S.; Kinney, W.; Koska, W.; Lamm, M.J.; Strait, J.B.; Wake, M.; Gordon, M.; Hassan, N.; Sims, R.; Winters, M.

    1991-03-01

    Several short model SSC 50 mm bore dipoles are being built and tested at Fermilab. Mechanical design of these magnets has been determined from experience involved in the construction and testing of 40 mm dipoles. Construction experience includes coil winding, curing and measuring, coil end part design and fabrication, ground insulation, instrumentation, collaring and yoke assembly. Fabrication techniques are explained and construction problems are discussed. Similarities and differences from the 40 mm dipole tooling and management components are outlined. Test results from the first models are presented. 19 refs., 12 figs

  20. Posouzení stability kotevního systému

    OpenAIRE

    Krško, Matúš

    2012-01-01

    Bakalárska práca je zameraná na problematiku stability kotevného systému. Teoretická časť sa zaoberá rozdelením a technológiou výstavby kotvených stien a poruchovými stavmi, ktoré môžu nastať. Ďalej sú predstavené metódy na posúdenie vnútornej stability systému. Vo výpočtovej časti sú tieto metódy aplikované na vzorový príklad. V závere práce sú získané výsledky vyhodnotené. Bachelor´s thesis is focused on stability of anchored system. Theoretical part deals with various types of anchored ...

  1. Demonstration of a hybrid Ho:YLF Ho:LuLF slab laser

    CSIR Research Space (South Africa)

    Esser, MJD

    2010-10-01

    Full Text Available % at 2 ?m were selected as output couplers. The hybrid stable-unstable resonator configuration utilised a cylindrical mirror of curvature r = 449 mm in position M4 and a knife-edge mirror to couple out the laser beam. In both configurations the total...

  2. Deniss Karpak piirdus MM-il 26. kohaga

    Index Scriptorium Estoniae

    2008-01-01

    Vt. ka Linnaleht : Tallinn : na russkom jazõke, Linnaleht : Tartu 13. veebr., lk. 6. Austraalias Terrigalis purjetamise Laser-klassi MM-il lõpetas Deniss Karpak 26. kohal. Vt. ka Linnaleht : Tartu 14.veebr.

  3. QM/MM investigations of organic chemistry oriented questions.

    Science.gov (United States)

    Schmidt, Thomas C; Paasche, Alexander; Grebner, Christoph; Ansorg, Kay; Becker, Johannes; Lee, Wook; Engels, Bernd

    2014-01-01

    About 35 years after its first suggestion, QM/MM became the standard theoretical approach to investigate enzymatic structures and processes. The success is due to the ability of QM/MM to provide an accurate atomistic picture of enzymes and related processes. This picture can even be turned into a movie if nuclei-dynamics is taken into account to describe enzymatic processes. In the field of organic chemistry, QM/MM methods are used to a much lesser extent although almost all relevant processes happen in condensed matter or are influenced by complicated interactions between substrate and catalyst. There is less importance for theoretical organic chemistry since the influence of nonpolar solvents is rather weak and the effect of polar solvents can often be accurately described by continuum approaches. Catalytic processes (homogeneous and heterogeneous) can often be reduced to truncated model systems, which are so small that pure quantum-mechanical approaches can be employed. However, since QM/MM becomes more and more efficient due to the success in software and hardware developments, it is more and more used in theoretical organic chemistry to study effects which result from the molecular nature of the environment. It is shown by many examples discussed in this review that the influence can be tremendous, even for nonpolar reactions. The importance of environmental effects in theoretical spectroscopy was already known. Due to its benefits, QM/MM can be expected to experience ongoing growth for the next decade.In the present chapter we give an overview of QM/MM developments and their importance in theoretical organic chemistry, and review applications which give impressions of the possibilities and the importance of the relevant effects. Since there is already a bunch of excellent reviews dealing with QM/MM, we will discuss fundamental ingredients and developments of QM/MM very briefly with a focus on very recent progress. For the applications we follow a similar

  4. Valuing spectrum at mm wavelengths for cellular networks

    OpenAIRE

    Shaw, B. A.; Beltrán, H. F.; Sowerby, K. W.

    2017-01-01

    This paper investigates the economic value of spectrum at mm wavelengths. The analysis uses four techniques to value spectrum, namely a benchmarking comparison, a discounted cash flow analysis, a real options approach and a deprival method. The methods to calculate spectrum value presented in this paper can be used for any spectrum band and in any country. However, to determine the value of mm wavelengths for cellular networks, we have used data from New Zealand, specifically for the existing...

  5. A comparative study of shadow shield whole body monitor incorporated with 203 mm dia. x 102 mm thick and 102 mm dia. x 76 mm thick NaI(TI) detectors

    International Nuclear Information System (INIS)

    Sankhla, Rajesh; Singh, I.S.; Rao, D.D.

    2016-01-01

    The whole body counting using Shadow Shield Whole Body Monitor (SSWBM) proved to be a popular method for assessment of internal contamination due to high energy gamma (E>200 keV) emitting radio nuclides that got inadvertently incorporated in the occupational workers. Currently ∼ 5 SSWBMs are operational at various DAE nuclear facilities throughout the country. The shielding of SSWBMs are said to be designed for 102 mm x 76 mm NaI(Tl) detector and over a period of time, the same concept is being followed. At present, the number of subjects monitored per annum has increased significantly compared to earlier years due to the increase in nuclear facilities at different sites and also increase in number of contract personnel. Aim of this study is to develop/upgrade the existing SSWBMs to increase their capabilities in terms of throughput without compromising on sensitivity. This work includes response studies of individual detectors of sizes 102 mm x 76 mm and 203 mm x 102 mm housed in SSWBM in terms of background, efficiency and Minimum Detection Activity (MDA) for different gamma emitting radio nuclides using Bhabha Atomic Research Centre reference Bottle Mannequin ABsorption (BOMAB) phantom

  6. QM/MM free energy simulations: recent progress and challenges

    Science.gov (United States)

    Lu, Xiya; Fang, Dong; Ito, Shingo; Okamoto, Yuko; Ovchinnikov, Victor

    2016-01-01

    Due to the higher computational cost relative to pure molecular mechanical (MM) simulations, hybrid quantum mechanical/molecular mechanical (QM/MM) free energy simulations particularly require a careful consideration of balancing computational cost and accuracy. Here we review several recent developments in free energy methods most relevant to QM/MM simulations and discuss several topics motivated by these developments using simple but informative examples that involve processes in water. For chemical reactions, we highlight the value of invoking enhanced sampling technique (e.g., replica-exchange) in umbrella sampling calculations and the value of including collective environmental variables (e.g., hydration level) in metadynamics simulations; we also illustrate the sensitivity of string calculations, especially free energy along the path, to various parameters in the computation. Alchemical free energy simulations with a specific thermodynamic cycle are used to probe the effect of including the first solvation shell into the QM region when computing solvation free energies. For cases where high-level QM/MM potential functions are needed, we analyze two different approaches: the QM/MM-MFEP method of Yang and co-workers and perturbative correction to low-level QM/MM free energy results. For the examples analyzed here, both approaches seem productive although care needs to be exercised when analyzing the perturbative corrections. PMID:27563170

  7. The mm-wave compact component of AGN

    Science.gov (United States)

    Behar, Ehud; Vogel, Stuart; Baldi, Ranieri D.; Smith, Krista L.; Mushotzky, Richard F.

    2018-05-01

    mm-wave emission from Active Galactic Nuclei (AGN) may hold the key to understanding the physical origin of their radio cores. The correlation between radio/mm and X-ray luminosity may suggest a similar physical origin of the two sources. Since synchrotron self absorption decreases with frequency, mm-waves probe smaller length scales than cm-waves. We report on 100 GHz (3 mm) observations with CARMA of 26 AGNs selected from the hard X-ray Swift/BAT survey. 20/26 targets were detected at 100 GHz down to the 1 mJy (3σ) sensitivity, which corresponds to optically thick synchrotron source sizes of 10-4 - 10-3 pc. Most sources show a 100 GHz flux excess with respect to the spectral slope extrapolated from low frequencies. This mm spectral component likely originates from smaller scales than the few-GHz emission. The measured mm sources lie roughly around the Lmm (100 GHz) ˜10-4LX (2-10 keV) relation, similar to a few previously published X-ray selected sources, and hinting perhaps at a common coronal origin.

  8. Extratumoral Heme Oxygenase-1 (HO-1 Expressing Macrophages Likely Promote Primary and Metastatic Prostate Tumor Growth.

    Directory of Open Access Journals (Sweden)

    Sofia Halin Bergström

    Full Text Available Aggressive tumors induce tumor-supporting changes in the benign parts of the prostate. One factor that has increased expression outside prostate tumors is hemoxygenase-1 (HO-1. To investigate HO-1 expression in more detail, we analyzed samples of tumor tissue and peritumoral normal prostate tissue from rats carrying cancers with different metastatic capacity, and human prostate cancer tissue samples from primary tumors and bone metastases. In rat prostate tumor samples, immunohistochemistry and quantitative RT-PCR showed that the main site of HO-1 synthesis was HO-1+ macrophages that accumulated in the tumor-bearing organ, and at the tumor-invasive front. Small metastatic tumors were considerably more effective in attracting HO-1+ macrophages than larger non-metastatic ones. In clinical samples, accumulation of HO-1+ macrophages was seen at the tumor invasive front, almost exclusively in high-grade tumors, and it correlated with the presence of bone metastases. HO-1+ macrophages, located at the tumor invasive front, were more abundant in bone metastases than in primary tumors. HO-1 expression in bone metastases was variable, and positively correlated with the expression of macrophage markers but negatively correlated with androgen receptor expression, suggesting that elevated HO-1 could be a marker for a subgroup of bone metastases. Together with another recent observation showing that selective knockout of HO-1 in macrophages reduced prostate tumor growth and metastatic capacity in animals, the results of this study suggest that extratumoral HO-1+ macrophages may have an important role in prostate cancer.

  9. Broadband Mm-Wave OFDM Communications in Doubly Selective Channel: Performance Evaluation Using Measured Mm-Wave Channel

    DEFF Research Database (Denmark)

    Chen, Xiaoming; Fan, Wei; Pedersen, Gert F.

    2018-01-01

    In this work, we evaluate the performance of the broadband millimeter-wave (mm-wave) OFDM system in the presence of phase noise (PN) of phase-locked loop based oscillator and delay spread of measured mm-wave channel. It is shown, using Akaike's information criterion, that the channel tap...... coefficients of the broadband mm-wave channel do not follow Gaussian distribution due to the broad bandwidth. It is also shown that, given a cyclic prefix (CP) length for a certain delay spread, an effective PN mitigation scheme enables a PN corrupted OFDM system to function with small subcarrier spacing and...

  10. An Adaptive Allocation Algorithm Using Directional CSMA/CA over mmWave Wireless Personal Area Networks

    Directory of Open Access Journals (Sweden)

    Hyunhee Park

    2012-04-01

    Full Text Available Directional antennas have the considerable benefits of higher antenna gain, long transmission distance and spatial reuse compared to omni-antennas. To support a directional antenna, IEEE 802.15.3c specifies a high data transmission rate and short frequency range communication based on the characteristics of 60GHz band. However, the contention-based protocol of IEEE 802.15.3c may cause channel collisions and throughput degradation as the number of stations in the network increases. In order to resolve this problem and reduce channel access latency, we propose an adaptive allocation algorithm in which the contention window size for optimal transmission probability is derived after the directional information has been obtained by means of AP control procedures. Extensive simulations demonstrate that the proposed algorithm outperforms the existing channel access scheme in IEEE 802.15.3c wireless personal area networks under different situations, especially when the number of contending stations is large.

  11. Measurement of cytoplasmic Ca2+ concentration in Saccharomyces cerevisiae induced by air cold plasma

    Science.gov (United States)

    Xiaoyu, DONG

    2018-03-01

    In this study, a novel approach to measure the absolute cytoplasmic Ca2+ concentration ([Ca2+]cyt) using the Ca2+ indicator fluo-3 AM was established. The parameters associated with the probe fluo-3 AM were optimized to accurately determine fluorescence intensity from the Ca2+-bound probe. Using three optimized parameters (final concentration of 6 mM probe, incubation time of 135 min, loading probe before plasma treatment), the maximum fluorescence intensity (F max = 527.8 a.u.) and the minimum fluorescence intensity (F min = 63.8 a.u.) were obtained in a saturated Ca2+ solution or a solution of lacking Ca2+. Correspondingly, the maximum [Ca2+]cyt induced by cold plasma was 1232.5 nM. Therefore, the Ca2+ indicator fluo-3 AM was successfully applied to measure the absolute [Ca2+]cyt in Saccharomyces cerevisiae stimulated by cold plasma at atmospheric air pressure.

  12. Renal hypertension prevents run training modification of cardiomyocyte diastolic Ca2+ regulation in male rats.

    Science.gov (United States)

    Palmer, B M; Lynch, J M; Snyder, S M; Moore, R L

    2001-06-01

    The combined effects of endurance run training and renal hypertension on cytosolic Ca2+ concentration ([Ca2+]c) dynamics and Na+-dependent Ca2+ regulation in rat left ventricular cardiomyocytes were examined. Male Fischer 344 rats underwent stenosis of the left renal artery [hypertensive (Ht), n = 18] or a sham operation [normotensive (Nt), n = 20]. One-half of the rats from each group were treadmill trained for >16 wk. Cardiomyocyte fura 2 fluorescence ratio transients were recorded for 7 min during electrical pacing at 0.5 Hz, 2 mM extracellular Ca2+ concentration, and 29 degrees C. The rate of [Ca2+]c decline was not changed by run training in the Nt group but was reduced in the Ht group. At 7 min, cardiomyocytes were exposed to 10 mM caffeine in the absence of Na+ and Ca2+, which triggered sarcoplasmic reticular Ca2+ release and suppressed Ca2+ efflux via Na+/Ca2+ exchanger. External Na+ was then added, and Na+-dependent Ca2+ efflux rate was recorded. Treadmill training significantly enhanced Na+-dependent Ca2+ efflux rate under these conditions in the Nt group but not in the Ht group. These data provide evidence that renal hypertension prevents the normal run training-induced modifications in diastolic [Ca2+]c regulation mechanisms, including Na+/Ca2+ exchanger.

  13. Effect of vanadate and of removal of extracellular Ca2+ and Na+ on tension development and 45Ca efflux in rat and frog myocardium

    DEFF Research Database (Denmark)

    Gesser, H; Bonefeld-Jørgensen, Eva Cecilie

    1983-01-01

    Vanadate in the range 0-5 mM has positive inotropic effects on myocardial strips of frog and to a lesser extent on those of rat. Inhibiting the sarcolemmal Na+, Ca2+ exchange by a solution free of Ca2+ and Na+ caused a drop in 45Ca efflux and a transient increase in resting tension. These effects...... were more expressed for the frog than for the rat myocardium, which suggests that the Na+ for Ca2+ exchange across the cell membrane is more important in the frog than in the rat myocardium. A subsequent addition of vanadate at 2 or 5 mM had no effect on 45Ca efflux, while it increased the resting...... tension. This increase was higher for the frog than for the rat myocardium. These results suggest that the inotropic effects of vanadate may be due to an effect on membrane-bound Ca2+-ATPase....

  14. Voltage-Induced Ca²⁺ Release in Postganglionic Sympathetic Neurons in Adult Mice.

    Directory of Open Access Journals (Sweden)

    Hong-Li Sun

    Full Text Available Recent studies have provided evidence that depolarization in the absence of extracellular Ca2+ can trigger Ca2+ release from internal stores in a variety of neuron subtypes. Here we examine whether postganglionic sympathetic neurons are able to mobilize Ca2+ from intracellular stores in response to depolarization, independent of Ca2+ influx. We measured changes in cytosolic ΔF/F0 in individual fluo-4 -loaded sympathetic ganglion neurons in response to maintained K+ depolarization in the presence (2 mM and absence of extracellular Ca2+ ([Ca2+]e. Progressive elevations in extracellular [K+]e caused increasing membrane depolarizations that were of similar magnitude in 0 and 2 mM [Ca2+]e. Peak amplitude of ΔF/F0 transients in 2 mM [Ca2+]e increased in a linear fashion as the membrane become more depolarized. Peak elevations of ΔF/F0 in 0 mM [Ca2+]e were ~5-10% of those evoked at the same membrane potential in 2 mM [Ca2+]e and exhibited an inverse U-shaped dependence on voltage. Both the rise and decay of ΔF/F0 transients in 0 mM [Ca2+]e were slower than those of ΔF/F0 transients evoked in 2 mM [Ca2+]e. Rises in ΔF/F0 evoked by high [K+]e in the absence of extracellular Ca2+ were blocked by thapsigargin, an inhibitor of endoplasmic reticulum Ca2+ ATPase, or the inositol 1,4,5-triphosphate (IP3 receptor antagonists 2-aminoethoxydiphenyl borate and xestospongin C, but not by extracellular Cd2+, the dihydropyridine antagonist nifedipine, or by ryanodine at concentrations that caused depletion of ryanodine-sensitive Ca2+ stores. These results support the notion that postganglionic sympathetic neurons possess the ability to release Ca2+ from IP3-sensitive internal stores in response to membrane depolarization, independent of Ca2+ influx.

  15. Neutron diffraction studies of Ho1-xYxNi2B2C compounds

    DEFF Research Database (Denmark)

    Chang, L.J.; Tomy, C.V.; Paul, D.M.K.

    1996-01-01

    Neutron diffraction measurements have been carried out to investigate the nature of magnetic ordering in Ho(1-x)Y(x)Ni(2)B(2)C (x = 0, 0.1 and 0.2) compounds. HoNi(2)B(2)C shows a complex type of magnetic ordering below the superconducting transition, with a commensurate antiferromagnetic ordering...

  16. Ozone decomposition in water studied by pulse radiolysis. 2. OH and HO4 as chain intermediates

    International Nuclear Information System (INIS)

    Staehelin, J.; Buehler, R.E.; Hoigne, J.

    1984-01-01

    Ozone decomposition in pure water involves a chain mechanism, initiated by the reaction OH - +O 3 and propogated by O 2 - and OH. In the present studies this chain is initiated by pulse radiolysis of aqueous solutions of ozone. The chain propogation steps were studied in two parts. By computer simulation of the rate curves, it is shown that from OH + O 3 and intermediate HO 4 must be formed, most likely a charge-transfer complex (HO.O 3 ), which eventually decays into HO 2 . The derived rate constants for the formation of the various species are included. The spectrum of HO 4 is derived. It is similar to the one of ozone, but the absorption coefficients are about 50% larger. In the presence of high ozone concentration, the dominant chain termination reactions are HO 4 + HO 4 and HO 4 + HO 3 . The effect on chain length, dose, overall rate, and pH and of added scavengers is described. The implications for the natural ozone decay mechanism are discussed

  17. HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues.

    Science.gov (United States)

    Zukor, Hillel; Song, Wei; Liberman, Adrienne; Mui, Jeannie; Vali, Hojatollah; Fillebeen, Carine; Pantopoulos, Kostas; Wu, Ting-Di; Guerquin-Kern, Jean-Luc; Schipper, Hyman M

    2009-05-01

    Oxidative stress, deposition of non-transferrin iron, and mitochondrial insufficiency occur in the brains of patients with Alzheimer disease (AD) and Parkinson disease (PD). We previously demonstrated that heme oxygenase-1 (HO-1) is up-regulated in AD and PD brain and promotes the accumulation of non-transferrin iron in astroglial mitochondria. Herein, dynamic secondary ion mass spectrometry (SIMS) and other techniques were employed to ascertain (i) the impact of HO-1 over-expression on astroglial mitochondrial morphology in vitro, (ii) the topography of aberrant iron sequestration in astrocytes over-expressing HO-1, and (iii) the role of iron regulatory proteins (IRP) in HO-1-mediated iron deposition. Astroglial hHO-1 over-expression induced cytoplasmic vacuolation, mitochondrial membrane damage, and macroautophagy. HO-1 promoted trapping of redox-active iron and sulfur within many cytopathological profiles without impacting ferroportin, transferrin receptor, ferritin, and IRP2 protein levels or IRP1 activity. Thus, HO-1 activity promotes mitochondrial macroautophagy and sequestration of redox-active iron in astroglia independently of classical iron mobilization pathways. Glial HO-1 may be a rational therapeutic target in AD, PD, and other human CNS conditions characterized by the unregulated deposition of brain iron.

  18. Paracrine action of HO-1-modified mesenchymal stem cells mediates cardiac protection and functional improvement.

    Science.gov (United States)

    Zeng, Bin; Ren, Xiaofeng; Lin, Guosheng; Zhu, Chengang; Chen, Honglei; Yin, Jiechao; Jiang, Hong; Yang, Bo; Ding, Danhua

    2008-10-01

    The aim has been to determine whether the supernatants of mesenchymal stem cells (MSCs) transfected with adenovirus carrying human heme oxygenase-1 (hHO-1) gene protect cardiomyocytes from ischemic injury. We have found that hHO-1 infected MSCs (hHO-1-MSCs) increased expression of hHO-1 protein. Apoptosis of cultured hHO-1-MSCs exposed to hypoxia was suppressed. Several cytokines, including HGF, bFGF, TGF-beta, VEGF and IL-1beta, were produced by hHO-1-MSCs, some being significantly enhanced under hypoxia stimulation. Meanwhile, those cytokines reduced caspase-3 level and activity in cultured adult rat ventricular cardiomyocytes (ARVCs) exposed to hypoxia. Supernatants obtained from hHO-1-MSCs improved left ventricular function, limited myocardial infarct size, increased microvessel density, and inhibited apoptosis of cardiomyocytes in rat myocardial infarction. It can be concluded hHO-1-modified MSCs prevent myocardial cell injury via secretion of paracrine-acting mediators.

  19. Efficient Ho:YLF laser pumped by a Tm:fiber laser

    CSIR Research Space (South Africa)

    Koen, W

    2013-10-01

    Full Text Available A thulium fiber laser pumped Ho:YLF laser delivering 45.1 W in a near diffraction limited beam when pumped with 84.7 W is demonstrated. The optical-to-optical efficiency of 53 % compares favorably with similar Ho:YAG lasers....

  20. Q-switched Ho:YLF laser pumped by a Tm:GdVO4 laser.

    CSIR Research Space (South Africa)

    Esser, MJD

    2009-06-01

    Full Text Available The authors have, through careful analysis of spectroscopic data, designed and demonstrated a diode-end-pumped, quasicontinuous wave Tm:GdVO4 laser operating at 1892 nm in order to pump a Q-switched Ho:YLF laser. The Ho:YLF maximum output energy...

  1. Experimental Investigation of Phase Equilibria in the Ho-Ti-Si Ternary System at 973 K (700 °C)

    Science.gov (United States)

    Han, Feng; Zhan, Yongzhong

    2018-02-01

    Phase equilibrium relations of the Ho-Ti-Si ternary system at 973 K (700 °C) were experimentally researched by means of X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive spectrometer (EDS). The isothermal section of the system at 973 K (700 °C) consists of 14 three-phase regions, 27 two-phase regions, and 14 single-phase regions. The phases Ti5Si3, Ti5Si4, TiSi, TiSi2, Ho5Si3, Ho5Si4, HoSi, αHoSi2-b, and βHoSi2-a are proved to exist at 973 K (700 °C). Previously reported HoTiSi and Ho2Ti3Si4 ternary compounds were confirmed to exist at this temperature. The solubility of Ho in the intermediate phases (i.e., TiSi2, TiSi, Ti5Si4, and Ti5Si3) at the Ti-Si side is extremely small. The maximum solubilities of Ti in HoSi2-b, Ho5Si4, and Ho5Si3 are confirmed to be 8.0, 7.2, and 6.0 at. pct, respectively.

  2. Magnetic Resonance Imaging-Based Radiation-Absorbed Dose Estimation of Ho-166 Microspheres in Liver Radioembolization

    NARCIS (Netherlands)

    Seevinck, Peter R.; van de Maat, Gerrit H.; de Wit, Tim C.; Vente, Maarten A. D.; Nijsen, Johannes F. W.; Bakker, Chris J. G.

    2012-01-01

    Purpose: To investigate the potential of magnetic resonance imaging (MRI) for accurate assessment of the three-dimensional Ho-166 activity distribution to estimate radiation-absorbed dose distributions in Ho-166-loaded poly (L-lactic acid) microsphere (Ho-166-PLLA-MS) liver radioembolization.

  3. His Excellency Professor Dr Che-Ho Wei, Chairman, National Science Council Executive Yuan, Republic of China

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Photo 01: Professor Dr. Che-Ho Wei signing the Guest Book with CERN Director-General, L. Maiani. Photo 02: Professor Dr. Che-Ho Wei. Photo 03::Professor Dr. Che-Ho Wei shaking hands with CERN Director-General, L. Maiani.

  4. QM/MM Calculations with deMon2k

    Directory of Open Access Journals (Sweden)

    Dennis R. Salahub

    2015-03-01

    Full Text Available The density functional code deMon2k employs a fitted density throughout (Auxiliary Density Functional Theory, which offers a great speed advantage without sacrificing necessary accuracy. Powerful Quantum Mechanical/Molecular Mechanical (QM/MM approaches are reviewed. Following an overview of the basic features of deMon2k that make it efficient while retaining accuracy, three QM/MM implementations are compared and contrasted. In the first, deMon2k is interfaced with the CHARMM MM code (CHARMM-deMon2k; in the second MM is coded directly within the deMon2k software; and in the third the Chemistry in Ruby (Cuby wrapper is used to drive the calculations. Cuby is also used in the context of constrained-DFT/MM calculations. Each of these implementations is described briefly; pros and cons are discussed and a few recent applications are described briefly. Applications include solvated ions and biomolecules, polyglutamine peptides important in polyQ neurodegenerative diseases, copper monooxygenases and ultra-rapid electron transfer in cryptochromes.

  5. Ferromagnetic and paramagnetic magnetization of implanted GaN:Ho,Tb,Sm,Tm films

    Energy Technology Data Exchange (ETDEWEB)

    Maryško, M., E-mail: marysko@fzu.cz; Hejtmánek, J.; Laguta, V. [Institute of Physics of ASCR v.v.i., Cukrovarnická 10, 162 00 Prague 6 (Czech Republic); Sofer, Z.; Sedmidubský, D.; Šimek, P.; Veselý, M. [Department of Inorganic Chemistry, Institute of Chemical Technology, 166 28 Prague 6 (Czech Republic); Mikulics, M. [Peter Grünberg Institut, PGI-9, Forschung Centrum, Jülich D-52425 (Germany); JARA, Fundamentals of Future Information Technology, D52425 Jülich (Germany); Buchal, C. [Peter Grünberg Institut, PGI-9, Forschung Centrum, Jülich D-52425 (Germany); Macková, A.; Malínský, P. [Nuclear Physics Institute of the ASCR v.v.i., 250 68 Řež (Czech Republic); Department of Physics, Faculty of Science, J.E.Purkinje University, České mládeže, 400 96 Ústí nad Labem (Czech Republic); Wilhelm, R. A. [Helmholtz-Zentrum Dresden-Rossendorf, Institute of Ion Beam Physics and Materials Research, Dresden (Germany); Technische Universität Dresden, 01062 Dresden (Germany)

    2015-05-07

    The SQUID magnetic measurements were performed on the GaN films prepared by metal-organic vapour phase epitaxy and implanted by Tb{sup 3+}, Tm{sup 3+}, Sm{sup 3+}, and Ho{sup 3+} ions. The sapphire substrate was checked by the electron paramagnetic resonance method which showed a content of Cr{sup 3+} and Fe{sup 3+} impurities. The samples 5 × 5 mm{sup 2} were positioned in the classical straws and within an estimated accuracy of 10{sup −6 }emu, no ferromagnetic moment was detected in the temperature region of 2–300 K. The paramagnetic magnetization was studied for parallel and perpendicular orientation. In the case of GaN:Tb sample, at T = 2 K, a pronounced anisotropy with the easy axis perpendicular to the film was observed which can be explained by the lowest quasi-doublet state of the non-Kramers Tb{sup 3+} ion. The Weiss temperature deduced from the susceptibility data using the Curie-Weiss (C-W) law was found to depend substantially on the magnetic field.

  6. Marketingový mix výrobního družstva IRISA

    OpenAIRE

    Nguyen, Anh Duc

    2016-01-01

    Tato bakalářská práce je zaměřena marketing a konkrétně na marketingový mix produktů. V teoretické části vysvětlím základní pojmy marketingu a marketingového mixu. V analytické části provedu analýzy marketingového mixu vybraného podniku. V návrhové části sestavím návrhy na změny současného marketingového mixu. This thesis is focused specifically on marketing and marketing mix of products. The theoretical part explains the basic concepts of marketing and marketing mix. The analytical part w...

  7. Superdeformation studies in {sup 150}Tb and {sup 153}Ho

    Energy Technology Data Exchange (ETDEWEB)

    Nisius, D.; Janssens, R.V.F.; Crowell, B. [and others

    1995-08-01

    There are now over 40 superdeformed (SD) bands known in the A {approximately} 150 region and in most cases the properties of these bands are understood in terms of single-particle excitations in the absence of pairing. By continuing the search for new SD bands we hope to gain insight into (1) the ordering of the proton and neutron orbitals near the Fermi surface in the SD well, (2) the effects that the alignment of those orbitals has on the moments of inertia, and (3) the collective excitations in the SD well. For {sup 150}Tb, which is one proton and one neutron away from the SD doubly-magic nucleus {sup 152}Dy, it should be possible to study SD bands based on both proton and neutron hole excitations. By adding one proton to the {sup 152}Dy nucleus (i.e. {sup 153}Ho) proton excitations above the Z = 66 shell gap can be studied. These excitations are important as calculations suggested that the proton intruder orbital N = 7 might become occupied. Interactions between this orbital and a N = 5 level may result in softness towards octupole vibrations. High spin states in {sup 150}Th and {sup 153}Ho were populated using the {sup 124}Sn({sup 31}P,5n) and {sup 120}Sn({sup 37}Cl,4n) reactions, respectively. In both cases the early implementation phase of Gammasphere was used to detect the decay gamma rays and over 1 x 10{sup 9} triple and higher fold coincidence events were recorded. In {sup 150}Tb, the data analysis is complete and two new SD bands were identified. The fact that Im{sup (2)} moments of inertia are sensitive to the specific high-N intruder content of the SD bands was used to suggest configurations for the two new bands. A paper reporting these results is being prepared. For {sup 153}Ho, data analysis is still in its early stages.

  8. Experimentally stabilized superconducting magnet with inner diameter of 700 mm

    Energy Technology Data Exchange (ETDEWEB)

    Vetlitskii, I A; Belonogov, A V; Dobrov, V M; Krylov, V L; Lebedev, A V; Lomkatsi, G S; Nilov, A F; Smolyankin, V T

    1974-05-01

    An experimental magnet, SPM-70, with the following characteristics was constructed. The inner diameter of the winding was 730 mm; outer diameter of the winding 1000 mm; height of winding 310 mm; magnetic induction at the center of the magnet 1.45 T; maximum magnetic induction 2.4 T; operation current 820 A; ampere-turns 1.07 x 10/sup 6/; design current density 2560 A/cm/sup 2/; stored energy 500 kJ; superconducting alloy Nb+50% Zr; weight of superconductor 23 kg; weight of copper 210 kg; resistivity of the copper in the strips at T = 4.2 K, B = 2.5 T, 2.6 x 10/sup -8/ ..cap omega.. cm.

  9. Trace analysis for 300 MM wafers and processes with TXRF

    International Nuclear Information System (INIS)

    Nutsch, A.; Erdmann, V.; Zielonka, G.; Pfitzner, L.; Ryssel, H.

    2000-01-01

    Efficient fabrication of semiconductor devices is combined with an increasing size of silicon wafers. The contamination level of processes, media, and equipment has to decrease continuously. A new test laboratory for 300 mm was installed in view of the above mentioned aspects. Aside of numerous processing tools this platform consist electrical test methods, particle detection, vapor phase decomposition (VPD) preparation, and TXRF. The equipment is installed in a cleanroom. It is common to perform process or equipment control, development, evaluation and qualification with monitor wafers. The evaluation and the qualification of 300 mm equipment require direct TXRF on 300 mm wafers. A new TXRF setup was installed due to the wafer size of 300 mm. The 300 mm TXRF is equipped with tungsten and molybdenum anode. This combination allows a sensitive detection of elements with fluorescence energy below 10 keV for tungsten excitation. The molybdenum excitation enables the detection of a wide variety of elements. The detection sensitivity for the tungsten anode excited samples is ten times higher than for molybdenum anode measured samples. The system is calibrated with 1 ng Ni. This calibration shows a stability within 5 % when monitored to control system stability. Decreasing the amount of Ni linear results in a linear decrease of the measured Ni signal. This result is verified for a range of elements by multielement samples. New designs demand new processes and materials, e.g. ferroelectric layers and copper. The trace analysis of many of these materials is supported by the higher excitation energy of the molybdenum anode. Reclaim and recycling of 300 mm wafers demand for an accurate contamination control of the processes to avoid cross contamination. Polishing or etching result in modified surfaces. TXRF as a non-destructive test method allows the simultaneously detection of a variety of elements on differing surfaces in view of contamination control and process

  10. 450mm wafer patterning with jet and flash imprint lithography

    Science.gov (United States)

    Thompson, Ecron; Hellebrekers, Paul; Hofemann, Paul; LaBrake, Dwayne L.; Resnick, Douglas J.; Sreenivasan, S. V.

    2013-09-01

    The next step in the evolution of wafer size is 450mm. Any transition in sizing is an enormous task that must account for fabrication space, environmental health and safety concerns, wafer standards, metrology capability, individual process module development and device integration. For 450mm, an aggressive goal of 2018 has been set, with pilot line operation as early as 2016. To address these goals, consortiums have been formed to establish the infrastructure necessary to the transition, with a focus on the development of both process and metrology tools. Central to any process module development, which includes deposition, etch and chemical mechanical polishing is the lithography tool. In order to address the need for early learning and advance process module development, Molecular Imprints Inc. has provided the industry with the first advanced lithography platform, the Imprio® 450, capable of patterning a full 450mm wafer. The Imprio 450 was accepted by Intel at the end of 2012 and is now being used to support the 450mm wafer process development demands as part of a multi-year wafer services contract to facilitate the semiconductor industry's transition to lower cost 450mm wafer production. The Imprio 450 uses a Jet and Flash Imprint Lithography (J-FILTM) process that employs drop dispensing of UV curable resists to assist high resolution patterning for subsequent dry etch pattern transfer. The technology is actively being used to develop solutions for markets including NAND Flash memory, patterned media for hard disk drives and displays. This paper reviews the recent performance of the J-FIL technology (including overlay, throughput and defectivity), mask development improvements provided by Dai Nippon Printing, and the application of the technology to a 450mm lithography platform.

  11. Dy163-Ho163 branching: an s-process barometer

    International Nuclear Information System (INIS)

    Beer, H.; Walter, G.; Macklin, R.L.

    1984-01-01

    The neutron capture cross sections of Dy163 and Er164 have been measured to analyze the s-process branching at Dy163-Ho163. The reproduction of the s-process abundance of Er164 via this branching is sensitive to temperature kT, neutron density, and electron density n/sub e/. The calculations using information from other branchings on kT and the neutron density n/sub n/ give constraints for n/sub e/ at the site of the s-process

  12. The complexes of Ho with methylenediphosphonate and 1 hydroxyethylidenephosphonate

    International Nuclear Information System (INIS)

    Vanura, P.; Jedinakova-Krizova, V.; Hakenova, L.; Munesawa, Y.

    1999-01-01

    The composition and stability of holmium methylenediphosphonate (MDP) and 1-hydroxyethylidenephosphonate (HEDP) complexes in the aqueous solution of 0.1 M NaCl at the temperature of 25 grad C were studied by potentiometric titration methods. The complexes of the composition HoH n L have been found in the aqueous solution if the concentration of the ligand is higher than the concentration of holmium. The protonation constants of both acids and stability constants of all complexes were determined and the comparison with literature data of analogical complexes of other lanthanides was performed. (authors)

  13. Ultra-violet emission in Ho:ZBLAN fiber

    International Nuclear Information System (INIS)

    Kowalska, M.; Klocek, G.; Piramidowicz, R.; Malinowski, M.

    2004-01-01

    We report on the short wavelength (green, blue, and ultra-violet (UV)) emission in trivalent holmium doped fluoro-zirconate fiber (Ho 3+ :ZBLAN) under direct and upconversion pumping. Efficient red to UV upconversion has been observed using 647 nm cw pumping by krypton ion laser. A close to cubic UV signal intensity dependence on incident red pump power was determined, confirming the three-photon character of the observed process. The responsible upconversion mechanisms were investigated and shown to be excited state absorption (ESA) via low-lying 5 I 7 and 5 I 6 sates. Dynamics of the involved excited states have been studied under pulsed laser excitation

  14. Microcoaxial cataract surgery outcomes: comparison of 1.8 mm system and 2.2 mm system.

    Science.gov (United States)

    Lee, Kyung-Min; Kwon, Hyung-Goo; Joo, Choun-Ki

    2009-05-01

    To compare clinical outcomes of a 1.8 mm and a 2.2 mm microcoaxial cataract surgery system. Department of Ophthalmology and Visual Science, Kangnam St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea. In a prospective study, eyes were randomly selected to have phacoemulsification using a Stellaris system or an Intrepid Infiniti system. The initial incision size was 1.8 mm and 2.2 mm, respectively. Measured intraoperative parameters included phacoemulsification time, mean cumulative dissipated ultrasound energy (CDE), change in incision size at each step of surgery, and total volume of balanced salt solution (BSS) used. The best corrected visual acuity (BCVA), corneal astigmatism, corneal thickness, and endothelial cell count were evaluated preoperatively and postoperatively. The study evaluated 86 eyes of 78 patients (43 eyes in each group). There were no significant differences in postoperative BCVA, surgically induced astigmatism, or amount of BSS used between the 2 systems (P >.05). However, for high-density cataracts, the 1.8 mm group had a greater change between the initial incision size and the incision size after phacoemulsification (P = .019, nuclear opalescence [NO] NO3; P = .001, NO4), a longer phacoemulsification time (P = .013, NO3), greater mean CDE (P = .005, NO3; P = .001, NO4), and greater corneal endothelial cell loss (P = .003, NO4). Both systems were safe and effective in microcoaxial phacoemulsification. The 1.8 mm system performed better with cortical-type cataract and the 2.2 mm system, with high-density nuclear-type cataract.

  15. Combined quantum and molecular mechanics (QM/MM).

    Science.gov (United States)

    Friesner, Richard A

    2004-12-01

    We describe the current state of the art of mixed quantum mechanics/molecular mechanics (QM/MM) methodology, with a particular focus on modeling of enzymatic reactions. Over the past decade, the effectiveness of these methods has increased dramatically, based on improved quantum chemical methods, advances in the description of the QM/MM interface, and reductions in the cost/performance of computing hardware. Two examples of pharmaceutically relevant applications, cytochrome P450 and class C β-lactamase, are presented.: © 2004 Elsevier Ltd . All rights reserved.

  16. MM-rallin vaikutus Toyotan brändiin

    OpenAIRE

    Laurila, Heini

    2017-01-01

    Tämän insinöörityön tarkoituksena oli selvittää, millainen vaikutus MM-ralliin palaamisella on Toyotan brändiin Suomessa. Insinöörityö toteutettiin yhteistyössä Suomen Toyotan ja Lexuksen maahantuojayrityksen, Toyota Auto Finland Oy:n sekä AKK Sports Oy:n kanssa. AKK Sports Oy on vastuussa vuosittaisen Suomen MM-ralliosakilpailun, Neste Rallin, järjestämisestä. Tutkimuksen taustatyönä tutustuttiin ensin brändejä ja markkinointia koskevaan kirjallisuuteen. Sen lisäksi käytiin läpi Toyotan ...

  17. Computational Modeling in Plasma Processing for 300 mm Wafers

    Science.gov (United States)

    Meyyappan, Meyya; Arnold, James O. (Technical Monitor)

    1997-01-01

    Migration toward 300 mm wafer size has been initiated recently due to process economics and to meet future demands for integrated circuits. A major issue facing the semiconductor community at this juncture is development of suitable processing equipment, for example, plasma processing reactors that can accomodate 300 mm wafers. In this Invited Talk, scaling of reactors will be discussed with the aid of computational fluid dynamics results. We have undertaken reactor simulations using CFD with reactor geometry, pressure, and precursor flow rates as parameters in a systematic investigation. These simulations provide guidelines for scaling up in reactor design.

  18. Piezoelectric ultrasonic micromotor with 1.5 mm diameter.

    Science.gov (United States)

    Dong, Shuxiang; Lim, Siak P; Lee, Kwork H; Zhang, Jingdong; Lim, Leong C; Uchino, Kenji

    2003-04-01

    A piezoelectric ultrasonic micromotor has been developed using a lead zirconate titanate (PZT) ceramic/metal composite tube stator that was 1.5 mm in diameter and 7 mm in length. The micromotor was operated in its first bending vibration mode (approximately 70 kHz), producing speeds from hundreds to over 2000 rpm in both rotational directions. The maximum torque-output was 45 microN-m, which is far superior to previous PZT thin film-based micromotors. This micromotor showed good reliability and stability for more than 300 hours of continued operation.

  19. Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function.

    Science.gov (United States)

    Liu, Xiaoli; Pachori, Alok S; Ward, Christopher A; Davis, J Paul; Gnecchi, Massimiliano; Kong, Deling; Zhang, Lunan; Murduck, Jared; Yet, Shaw-Fang; Perrella, Mark A; Pratt, Richard E; Dzau, Victor J; Melo, Luis G

    2006-02-01

    We reported previously that predelivery of the anti-oxidant gene heme oxygenase-1 (HO-1) to the heart by adeno associated virus (AAV) markedly reduces injury after acute myocardial infarction (MI). However, the effect of HO-1 gene delivery on postinfarction recovery has not been investigated. In the current study, we assessed the effect of HO-1 gene delivery on post-MI left ventricle (LV) remodeling and function using echocardiographic imaging and histomorphometric approaches. Two groups of Sprague-Dawley rats were injected with 4 x 10(11) particles of AAV-LacZ (control) or AAV-hHO-1 in the LV wall. Eight wk after gene transfer, the animals were subjected to 30 min of ischemia by ligation of left anterior descending artery (LAD) followed by reperfusion. Echocardiographic measurements were obtained in a blinded fashion prior and at 1.5 and 3 months after I/R. Ejection fraction (EF) was reduced by 13% and 40% in the HO-1 and LacZ groups, respectively at 1.5 months after MI. Three months after MI, EF recovered fully in the HO-1, but only partially in the LacZ-treated animals. Post-MI LV dimensions were markedly increased and the anterior wall was markedly thinned in the LacZ-treated animals compared with the HO-1-treated animals. Significant myocardial scarring and fibrosis were observed in the LacZ-group in association with elevated levels of interstitial collagen I and III and MMP-2 activity. Post-MI myofibroblast accumulation was reduced in the HO-1-treated animals, and retroviral overexpression of HO-1 reduced proliferation of isolated cardiac fibroblasts. Our data indicate that rAAV-HO-1 gene transfer markedly reduces fibrosis and ventricular remodeling and restores LV function and chamber dimensions after myocardial infarction.

  20. QM/MM hybrid calculation of biological macromolecules using a new interface program connecting QM and MM engines

    Energy Technology Data Exchange (ETDEWEB)

    Hagiwara, Yohsuke; Tateno, Masaru [Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba Science City, Ibaraki 305-8571 (Japan); Ohta, Takehiro [Center for Computational Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba Science City, Ibaraki 305-8577 (Japan)], E-mail: tateno@ccs.tsukuba.ac.jp

    2009-02-11

    An interface program connecting a quantum mechanics (QM) calculation engine, GAMESS, and a molecular mechanics (MM) calculation engine, AMBER, has been developed for QM/MM hybrid calculations. A protein-DNA complex is used as a test system to investigate the following two types of QM/MM schemes. In a 'subtractive' scheme, electrostatic interactions between QM/MM regions are truncated in QM calculations; in an 'additive' scheme, long-range electrostatic interactions within a cut-off distance from QM regions are introduced into one-electron integration terms of a QM Hamiltonian. In these calculations, 338 atoms are assigned as QM atoms using Hartree-Fock (HF)/density functional theory (DFT) hybrid all-electron calculations. By comparing the results of the additive and subtractive schemes, it is found that electronic structures are perturbed significantly by the introduction of MM partial charges surrounding QM regions, suggesting that biological processes occurring in functional sites are modulated by the surrounding structures. This also indicates that the effects of long-range electrostatic interactions involved in the QM Hamiltonian are crucial for accurate descriptions of electronic structures of biological macromolecules.

  1. Test of freonless operation of resistive plate chambers with glass electrodes--1 mm gas gap vs 2 mm gas gap

    CERN Document Server

    Sakaue, H; Takahashi, T; Teramoto, Y

    2002-01-01

    Non-freon gas mixtures (Ar/iso-C sub 4 H sub 1 sub 0) were tested as the chamber gas for 1 and 2 mm gas gap Resistive Plate Chambers (RPCs) with float glass as the resistive electrodes, operated in the streamer mode. With the narrower (1 mm) gas gap, streamer charge is reduced (approx 1/3), which reduces the dead time (and dead area), associated with each streamer, improving the detection efficiency. The best performance was obtained for two cases: Ar/iso-C sub 4 H sub 1 sub 0 =50/50 and 60/40. For the 50/50 mixture, a detection efficiency of better than 98% was obtained for the 1 mm gap RPC, while the efficiency was 95% for the 2 mm gap RPC, each operated as a double-gap RPC. The measured time resolution (rms) was 1.45+-0.05 (2.52+-0.09) ns for the 1 (2) mm gap RPC for the 50/50 mixture.

  2. Influence of Striking Edge Radius (2 mm versus 8 mm) on Instrumented Charpy Data and Absorbed Energies

    Energy Technology Data Exchange (ETDEWEB)

    Lucon, E.

    2008-08-15

    The most commonly used test standards for performing Charpy impact tests (ISO 148 and ASTM E 23) envisage the use of strikers having different radii of the striking edge, i.e. 2 mm (ISO) and 8 mm (ASTM). The effect of striker geometry on Charpy results was extensively studied in the past in terms of absorbed energy measured by the machine encoder, but few investigations are available on the influence of striker configuration on the results of instrumented Charpy tests (characteristic forces, displacements and integrated energy). In this paper, these effects are investigated based on the analysis of published results from three interlaboratory studies and some unpublished Charpy data obtained at SCK-CEN. The instrumented variables which are the most sensitive to the radius of the striking edge are the maximum force and its corresponding displacement, with 8mm-strikers providing systematically higher values. Absorbed energies, obtained both from the instrumented trace and from the pendulum encoder, are almost insensitive to the type of striker up to 200 J. For higher energy levels, the values obtained from 8mm strikers become progressively larger. Data scatter is generally higher for 2mm-strikers.

  3. Development of Low Density CaMg-A1-Based Bulk Metallic Glasses (Preprint)

    National Research Council Canada - National Science Library

    Senkov, O. N; Scott, J. M; Miracle, D. B

    2006-01-01

    Low density Ca-Mg-Al-based bulk metallic glasses containing additionally Cu and Zn, were produced by a copper mold casting method as wedge-shaped samples with thicknesses varying from 0.5 mm to 10 rom...

  4. MM&T: Bibliography on Optical Testing with Appendix.

    Science.gov (United States)

    1982-02-26

    OTTENUTE CON UN RETICOLO A TRATTI INCLINATI SUL PIANO DE SIM1ETRIA DEL SISTEMA OTTICO" Nuovo Cimento, 8, 310 (1931) No abstract provided. SCANDONE, F...FRANCIA, G. "SULLA FRANGE D’INTERFERENZA DELLE ONDE ABERRANTI" Ottica. 6, 151 (1941) No abstract provided. TORALDO DI FRANCIA, G. "SAUGIO DI UNA TEORIA ...No abstract provided. TORALDO DI FRANCIA, G. "INTRODUZIONE ALIA TEORIA GEOMETR[CA E INTERFERENZIALE DELLE ONDE ABERRANTI" Atti. Fond. Giorgio Ronchi

  5. QM/MM-MD simulations of conjugated polyelectrolytes

    DEFF Research Database (Denmark)

    Sjöqvist, Jonas; Linares, Mathieu; Mikkelsen, Kurt Valentin

    2014-01-01

    A methodological development is reported for the study of luminescence properties of conjugated polyelectrolytes, encompassing systems in which dihedral rotational barriers are easily overcome at room temperature. The components of the model include (i) a molecular mechanics (MM) force field desc...

  6. Film Editing Handbook; Technique of 16mm Film Cutting.

    Science.gov (United States)

    Churchill, Hugh B.

    Designed to help the film student with the complexities of 16mm film cutting, this handbook catalogs the mechanical procedures of both picture and sound cutting and supplies step-by-step explanations of these procedures. Because the handbook was organized so that it could be used while working at the cutting bench, common cutting problems and…

  7. Millimeter wave VAlidation STandard (mm-VAST) antenna

    DEFF Research Database (Denmark)

    Kim, Oleksiy S.

    This document summarizes the main results of the project “Millimeter wave VAlidation STandard (mm-VAST) antenna” completed by the Technical University of Denmark (DTU) in collaboration with Danish company TICRA for the European Space Agency (ESA) under ESA contract no. 4000109866/13/NL/MH....

  8. Millimeter wave VAlidation STandard (mm-VAST) antenna. Abstract

    DEFF Research Database (Denmark)

    Kim, Oleksiy S.

    This document outlines the background, objectives and the main results of the project “Millimeter wave VAlidation STandard (mm-VAST) antenna” completed by the Technical University of Denmark (DTU) in collaboration with Danish company TICRA for the European Space Agency (ESA) under ESA contract no...

  9. Radioimmunoassay of creatine kinase isoenzymes in human serum: isoenzyme MM

    International Nuclear Information System (INIS)

    Van Steirteghem, A.C.; Zweig, M.H.; Schechter, A.N.

    1978-01-01

    Measurement of the mass concentration of serum enzymes by radioimmunoassay provides direct quantitation of specific isoenzymes and may be less subject to some of the limitations of traditional assay procedures for enzymes. We describe the development of a sensitive and specific radioimmunoassay for the muscle isoenzyme of creatine kinase, CK-MM, in human serum. CK-MM, purified from human skeletal muscle, was used to raise high-titer antisera and for iodination by the Chloramine T method. The radioimmunoassay required 50 μl of sample, utilized a double-antibody separation method, and was completed in 24 h. Cross reactivity with CK-BB was virtually zero, 3 to 17 percent with CK-MB. The mass concentration of CK-MM in the serum of healthy subjects ranged from 36 to 1668 μg/liter and correlated closely with total CK enzymatic activity. Serum concentrations of CK-MM from casually selected patients correlated less well with total CK enzymatic activity, suggesting the existence of other CK isoenzymes or the presence of inactive forms

  10. Performance of 4mm impact sprinklers at different spacing within ...

    African Journals Online (AJOL)

    Irrigation Engineers in Zimbabwe use the 12 m x 18 m spacing for the design of the sprayline, using 4 mm nozzle sprinklers. A study was conducted to determine performance and cost effectiveness of other spacings that can be used in sprinkler irrigation systems design. The main targeted spacings were a square layout of ...

  11. Two-port laparoscopic ovarian cystectomy using 3-mm instruments

    Directory of Open Access Journals (Sweden)

    Naoyuki Yoshiki

    2016-05-01

    Conclusion: Two-port laparoscopic ovarian cystectomy using 3-mm instruments is a feasible and safe approach by which surgeons expert in conventional multiport laparoscopy achieve minimally invasive surgery with low morbidity and a low rate of conversion to the conventional approach.

  12. Broadband Mm-Wave OFDM Communications in Doubly Selective Channel: Performance Evaluation Using Measured Mm-Wave Channel

    DEFF Research Database (Denmark)

    Chen, Xiaoming; Fan, Wei; Pedersen, Gert F.

    2018-01-01

    coefficients of the broadband mm-wave channel do not follow Gaussian distribution due to the broad bandwidth. It is also shown that, given a cyclic prefix (CP) length for a certain delay spread, an effective PN mitigation scheme enables a PN corrupted OFDM system to function with small subcarrier spacing and......In this work, we evaluate the performance of the broadband millimeter-wave (mm-wave) OFDM system in the presence of phase noise (PN) of phase-locked loop based oscillator and delay spread of measured mm-wave channel. It is shown, using Akaike's information criterion, that the channel tap......, therefore, small CP overhead, with only slight degradation of the error rate performance....

  13. Mineralogic Model (MM3.0) Analysis Model Report

    Energy Technology Data Exchange (ETDEWEB)

    C. Lum

    2002-02-12

    The purpose of this report is to document the Mineralogic Model (MM), Version 3.0 (MM3.0) with regard to data input, modeling methods, assumptions, uncertainties, limitations and validation of the model results, qualification status of the model, and the differences between Version 3.0 and previous versions. A three-dimensional (3-D) Mineralogic Model was developed for Yucca Mountain to support the analyses of hydrologic properties, radionuclide transport, mineral health hazards, repository performance, and repository design. Version 3.0 of the MM was developed from mineralogic data obtained from borehole samples. It consists of matrix mineral abundances as a function of x (easting), y (northing), and z (elevation), referenced to the stratigraphic framework defined in Version 3.1 of the Geologic Framework Model (GFM). The MM was developed specifically for incorporation into the 3-D Integrated Site Model (ISM). The MM enables project personnel to obtain calculated mineral abundances at any position, within any region, or within any stratigraphic unit in the model area. The significance of the MM for key aspects of site characterization and performance assessment is explained in the following subsections. This work was conducted in accordance with the Development Plan for the MM (CRWMS M&O 2000). The planning document for this Rev. 00, ICN 02 of this AMR is Technical Work Plan, TWP-NBS-GS-000003, Technical Work Plan for the Integrated Site Model, Process Model Report, Revision 01 (CRWMS M&O 2000). The purpose of this ICN is to record changes in the classification of input status by the resolution of the use of TBV software and data in this report. Constraints and limitations of the MM are discussed in the appropriate sections that follow. The MM is one component of the ISM, which has been developed to provide a consistent volumetric portrayal of the rock layers, rock properties, and mineralogy of the Yucca Mountain site. The ISM consists of three components: (1

  14. Mineralogic Model (MM3.0) Analysis Model Report

    International Nuclear Information System (INIS)

    Lum, C.

    2002-01-01

    The purpose of this report is to document the Mineralogic Model (MM), Version 3.0 (MM3.0) with regard to data input, modeling methods, assumptions, uncertainties, limitations and validation of the model results, qualification status of the model, and the differences between Version 3.0 and previous versions. A three-dimensional (3-D) Mineralogic Model was developed for Yucca Mountain to support the analyses of hydrologic properties, radionuclide transport, mineral health hazards, repository performance, and repository design. Version 3.0 of the MM was developed from mineralogic data obtained from borehole samples. It consists of matrix mineral abundances as a function of x (easting), y (northing), and z (elevation), referenced to the stratigraphic framework defined in Version 3.1 of the Geologic Framework Model (GFM). The MM was developed specifically for incorporation into the 3-D Integrated Site Model (ISM). The MM enables project personnel to obtain calculated mineral abundances at any position, within any region, or within any stratigraphic unit in the model area. The significance of the MM for key aspects of site characterization and performance assessment is explained in the following subsections. This work was conducted in accordance with the Development Plan for the MM (CRWMS M and O 2000). The planning document for this Rev. 00, ICN 02 of this AMR is Technical Work Plan, TWP-NBS-GS-000003, Technical Work Plan for the Integrated Site Model, Process Model Report, Revision 01 (CRWMS M and O 2000). The purpose of this ICN is to record changes in the classification of input status by the resolution of the use of TBV software and data in this report. Constraints and limitations of the MM are discussed in the appropriate sections that follow. The MM is one component of the ISM, which has been developed to provide a consistent volumetric portrayal of the rock layers, rock properties, and mineralogy of the Yucca Mountain site. The ISM consists of three components

  15. [Interfering effects of radix Salviae miltiorrhizae and lingustrazine on mm-LDL activating BKCa in ECV304 cell].

    Science.gov (United States)

    Lin, L; Zheng, Y F; Qu, J H; Bao, G H

    2001-08-01

    To observe the action of minimally modified low density lipoprotein (mm-LDL) on BKCa in ECV304 cell and the interfering effects of radix salviae miltiorrhizae extract powder 764-3 (30 micrograms/ml) and lingustrazine (200 micrograms/ml) on this action. The cell-attached configuration of patch clamp technique was applied. mm-LDL (100 micrograms/ml) potentiated the activity of BKCa in ECV304. While 764-3 and lingustrazine abolished it. mm-LDL acted on vascular endothelial cell ECV304 could rapidly activate the activity of BKCa and might result in the increase of electro-chemical gradient for the resting Ca2+ influx, thus resting cytoplasmic concentration of calcium could be elevated and endothelial dysfunction would be induced. 764-3 and lingustrazine might have the protective action through decreasing the activity of BKCa.

  16. Charpy impact test results on five materials and NIST verification specimens using instrumented 2-mm and 8-mm strikers

    International Nuclear Information System (INIS)

    Nanstad, R.K.; Sokolov, M.A.

    1995-01-01

    The Heavy-Section Steel Irradiation Program at Oak Ridge National Laboratory is involved in two cooperative projects, with international participants, both of which involve Charpy V-notch impact tests with instrumented strikers of 2mm and 8mm radii. Two heats of A 533 grade B class I pressure vessel steel and a low upper-shelf (LUS) submerged-arc (SA) weld were tested on the same Charpy machine, while one heat of a Russian Cr-Mo-V forging steel and a high upper-shelf (HUS) SA weld were tested on two different machines. The number of replicate tests at any one temperature ranged from 2 to 46 specimens. Prior to testing with each striker, verification specimens at the low, high, and super high energy levels from the National Institute of Standards and Technology (NIST) were tested. In the two series of verification tests, the tests with the 2mm striker met the requirements at the low and high energy levels but not at the super high energy. For one plate, the 2mm striker showed somewhat higher average absorbed energies than those for the 8-mm striker at all three test temperatures. For the second plate and the LUS weld, however, the 2mm striker showed somewhat lower energies at both test temperatures. For the Russian forging steel and the HUS weld, tests were conducted over a range of temperatures with tests at one laboratory using the 8mm striker and tests at a second laboratory using the 2mm striker. Lateral expansion was measured for all specimens and the results are compared with the absorbed energy results. The overall results showed generally good agreement (within one standard deviation) in energy measurements by the two strikers. Load-time traces from the instrumented strikers were also compared and used to estimate shear fracture percentage. Four different formulas from the European Structural Integrity Society draft standard for instrumented Charpy test are compared and a new formula is proposed for estimation of percent shear from the force-time trace

  17. Radioactive ceramic seeds with Ho-166 and Sm-153 with perspective of use in brachytherapy

    International Nuclear Information System (INIS)

    Valente, Eduardo Sarmento

    2010-01-01

    This work aimed to characterize physically, chemically and radioactively ceramics seeds with holmium and samarium embedded in ceramic matrix produced by sol-gel route. Biological response of HeLa cells was investigated macroscopically in vitro under the exposure to β radiation of Ho-166 and Sm-153. The dispersal of radioactive material in simulated body fluid (SBF) was made and the dose rate and total dose deposited in the volume delimited by the range of β particles in the water was calculated. The methodology used in physical, chemical and nuclear characterization was based on the following techniques: atomic emission spectrometry, neutron activation analysis, gamma spectrometry, X-ray fluorescence spectrometry and X-rays diffraction. In addition to the solubility in SBF, an in vivo pilot study assessed the dispersion of radioactive seeds implanted in rabbit muscle tissue. Four experiments were prepared to investigate the biological response in vitro, in which radioactive seeds were placed directly in contact with the cells in confluent culture flasks. The first two were done with seed's activity of 3.7 MBq (0.1 mCi) for the Sm-153 and 11.1 MBq (0.3 mCi) for Ho-166. There were no concerns with spatial positioning for seeds in those early experiments. The subsequent experiments were performed with activity ranging from 37 MBq (1 mCi) and 111 MBq (3 mCi) and with defined position of the seeds in the flask. The results showed the presence of halos with maximum diameter of 8 mm around the seeds where there was a drastic reduction in the number of viable cells as a result of the effects of β radiation. The calculation of dose deposited in water as well as the dose rate calculation of during handling of the seeds for an implant followed the methodology established by MIRD. These calculations found dose rates ranging from 7 to 19 Gy/h and integrated doses between 93 and 730 Gy, due to β radiation, for 6 half-lives of radioisotopes Sm-153 and Ho-166. The dose

  18. A Piezoelectric Micromotor with a Stator of φ=1.6 mm and l=4 mm Using Bulk PZT

    Science.gov (United States)

    Cagatay, Serra; Koc, Burhanettin; Moses, Paul; Uchino, Kenji

    2004-04-01

    The smallest discrete piezoelectric ultrasonic motor using bulk ceramics was developed. We are proposing basically a two-part motor: stator and rotor. The stator of the present motor consists of a hollow metal brass tube with outer diameter of 1.6 mm, inner diameter of 0.8 mm and length of only 4 mm with 2 PZT plates bonded onto it. Owing to the asymmetrical stator surface, two degenerated orthogonal bending modes were slightly split, resulting in a wobbling motion. Thus, the motor can be driven by a single driving source. The rotor is a spring, which is basically different from previous designs, pressed at both ends to the stator by a pair of ferrules. Consequently, the length of the whole motor assembly was reduced significantly; a final motor length of only 5 mm was obtained. The working frequency under zero load was approximately 227-233 kHz. Although the size is small, relatively high power was obtained under an optimized load condition: torque of 0.06 mNm, maximum power of 3.2 mW with a speed of 118 rad/s, and maximum efficiency of 11% under 48 Vrms at 221 kHz.

  19. Prolonged triglyceride storage in macrophages: pHo trumps pO2 and TLR4.

    Science.gov (United States)

    Lu, Mingfang; Kho, Terry; Munford, Robert S

    2014-08-01

    Lipid-laden macrophages contribute to pathologies as diverse as atherosclerosis and tuberculosis. Three common stimuli are known to promote macrophage lipid storage: low tissue oxygen tension (pO2), low extracellular pH (pHo), and exposure to agonists such as bacterial LPS. Noting that cells responding to low pO2 or agonistic bacterial molecules often decrease pHo by secreting lactic and other carboxylic acids, we studied how pHo influences the stimulation of triacylglycerol (TAG) storage by low pO2 and LPS. We found that TAG retention after incubation for 48-72 h was inversely related to pHo when primary macrophages were cultured in 21% oxygen, 4% oxygen, or with LPS at either oxygen concentration. Maintaining pHo at ~7.4 was sufficient to prevent the increase in prolonged TAG storage induced by either low pO2 or LPS. The strong influence of pHo on TAG retention may explain why lipid-laden macrophages are found in some tissue environments and not in others. It is also possible that other long-term cellular changes currently attributed to low pO2 or bacterial agonists may be promoted, at least in part, by the decrease in pHo that these stimuli induce.

  20. HO-1 Upregulation Attenuates Adipocyte Dysfunction, Obesity, and Isoprostane Levels in Mice Fed High Fructose Diets

    Directory of Open Access Journals (Sweden)

    Zeid Khitan

    2014-01-01

    Full Text Available Background. Fructose metabolism is an unregulated metabolic pathway and excessive fructose consumption is known to activate ROS. HO-1 is a potent antioxidant gene that plays a key role in decreasing ROS and isoprostanes. We examined whether the fructose-mediated increase in adipocyte dysfunction involves an increase in isoprostanes and that pharmacological induction of HO-1 would decrease both isoprostane levels and adipogenesis. Methods and Results. We examined the effect of fructose, on adipogenesis in human MSCs in the presence and absence of CoPP, an inducer of HO-1. Fructose increased adipogenesis and the number of large lipid droplets while decreasing the number of small lipid droplets (P<0.05. Levels of heme and isoprostane in fructose treated MSC-derived adipocytes were increased. CoPP reversed these effects and markedly increased HO-1 and the Wnt signaling pathway. The high fructose diet increased heme levels in adipose tissue and increased circulating isoprostane levels (P<0.05 versus control. Fructose diets decreased HO-1 and adiponectin levels in adipose tissue. Induction of HO-1 by CoPP decreased isoprostane synthesis (P<0.05 versus fructose. Conclusion. Fructose treatment resulted in increased isoprostane production and adipocyte dysfunction, which was reversed by the increased expression of HO-1.

  1. Characterization of low temperature metallic magnetic calorimeters having gold absorbers with implanted 163Ho ions

    Science.gov (United States)

    Gastaldo, L.; Ranitzsch, P. C.-O.; von Seggern, F.; Porst, J.-P.; Schäfer, S.; Pies, C.; Kempf, S.; Wolf, T.; Fleischmann, A.; Enss, C.; Herlert, A.; Johnston, K.

    2013-05-01

    For the first time we have investigated the behavior of fully micro-fabricated low temperature metallic magnetic calorimeters (MMCs) after undergoing an ion-implantation process. This experiment had the aim to show the possibility to perform a high precision calorimetric measurement of the energy spectrum following the electron capture of 163Ho using MMCs having the radioactive 163Ho ions implanted in the absorber. The isotope 163Ho decays through electron capture to 163Dy and features the smallest known QEC value. This peculiarity makes 163Ho a very interesting candidate to investigate the value of the electron neutrino mass by the analysis of the energy spectrum. The implantation of 163Ho ions was performed at ISOLDE-CERN. The performance of a detector that underwent an ion-implantation process is compared to the one of a detector without implanted ions. The results show that the implantation dose of ions used in this experiment does not compromise the properties of the detector. Moreover the performance of the detector prototype having the 163Ho ions implanted in the absorber is already close to the requirements needed for an experiment with sub-eV sensitivity to the electron neutrino mass. Based on these results, an optimized detector design for future 163Ho experiments is presented.

  2. Characterization of low temperature metallic magnetic calorimeters having gold absorbers with implanted 163Ho ions

    International Nuclear Information System (INIS)

    Gastaldo, L.; Ranitzsch, P.C.-O.; Seggern, F. von; Porst, J.-P.; Schäfer, S.; Pies, C.; Kempf, S.; Wolf, T.; Fleischmann, A.; Enss, C.; Herlert, A.; Johnston, K.

    2013-01-01

    For the first time we have investigated the behavior of fully micro-fabricated low temperature metallic magnetic calorimeters (MMCs) after undergoing an ion-implantation process. This experiment had the aim to show the possibility to perform a high precision calorimetric measurement of the energy spectrum following the electron capture of 163 Ho using MMCs having the radioactive 163 Ho ions implanted in the absorber. The isotope 163 Ho decays through electron capture to 163 Dy and features the smallest known Q EC value. This peculiarity makes 163 Ho a very interesting candidate to investigate the value of the electron neutrino mass by the analysis of the energy spectrum. The implantation of 163 Ho ions was performed at ISOLDE-CERN. The performance of a detector that underwent an ion-implantation process is compared to the one of a detector without implanted ions. The results show that the implantation dose of ions used in this experiment does not compromise the properties of the detector. Moreover the performance of the detector prototype having the 163 Ho ions implanted in the absorber is already close to the requirements needed for an experiment with sub-eV sensitivity to the electron neutrino mass. Based on these results, an optimized detector design for future 163 Ho experiments is presented

  3. Epigallocatechin-3-gallate increases intracellular [Ca2+] in U87 cells mainly by influx of extracellular Ca2+ and partly by release of intracellular stores.

    Science.gov (United States)

    Kim, Hee Jung; Yum, Keun Sang; Sung, Jong-Ho; Rhie, Duck-Joo; Kim, Myung-Jun; Min, Do Sik; Hahn, Sang June; Kim, Myung-Suk; Jo, Yang-Hyeok; Yoon, Shin Hee

    2004-02-01

    Green tea has been receiving considerable attention as a possible preventive agent against cancer and cardiovascular disease. Epigallocatechin-3-gallate (EGCG) is a major polyphenol component of green tea. Using digital calcium imaging and an assay for [3H]-inositol phosphates, we determined whether EGCG increases intracellular [Ca2+] ([Ca2+]i) in non-excitable human astrocytoma U87 cells. EGCG induced concentration-dependent increases in [Ca2+]i. The EGCG-induced [Ca2+]i increases were reduced to 20.9% of control by removal of extracellular Ca2+. The increases were also inhibited markedly by treatment with the non-specific Ca2+ channel inhibitors cobalt (3 mM) for 3 min and lanthanum (1 mM) for 5 min. The increases were not significantly inhibited by treatment for 10 min with the L-type Ca2+ channel blocker nifedipine (100 nM). Treatment with the inhibitor of endoplasmic reticulum Ca2+-ATPase thapsigargin (1 micro M) also significantly inhibited the EGCG-induced [Ca2+]i increases. Treatment for 15 min with the phospholipase C (PLC) inhibitor neomycin (300 micro M) attenuated the increases significantly, while the tyrosine kinase inhibitor genistein (30 micro M) had no effect. EGCG increased [3H]-inositol phosphates formation via PLC activation. Treatment for 10 min with mefenamic acid (100 micro M) and flufenamic acid (100 micro M), derivatives of diphenylamine-2-carboxylate, blocked the EGCG-induced [Ca2+]i increase in non-treated and thapsigargin-treated cells but indomethacin (100 micro M) did not affect the increases. Collectively, these data suggest that EGCG increases [Ca2+]i in non-excitable U87 cells mainly by eliciting influx of extracellular Ca2+ and partly by mobilizing intracellular Ca2+ stores by PLC activation. The EGCG-induced [Ca2+]i influx is mediated mainly through channels sensitive to diphenylamine-2-carboxylate derivatives.

  4. Návrh změny metody konsolidace u vybraného konsolidovaného celku

    OpenAIRE

    Čadová, Michaela

    2017-01-01

    Téma diplomové práce je konsolidace účetní závěrky. Práce obsahuje teoretická východiska, která se týkají problematiky konsolidace účetní závěrky, a tyto poznatky jsou potom zúročeny v části praktické. Analytická část se zaobírá zhodnocením současného stavu, obsahuje tedy původní konsolidaci účetní závěrky zvolené společnosti. V návrhové části je aplikována nová metoda konsolidace účetní závěrky. Následně je zhodnocen dopad změny konsolidační metody na ekonomickou situaci konsolidačního celku...

  5. A 300-nm compact mm-wave linac FEL design

    Energy Technology Data Exchange (ETDEWEB)

    Nassiri, A.; Kustom, R.L.; Kang, Y.W. [Argonne National Lab., IL (United States)

    1995-12-31

    Microfabrication technology offers an alternative method for fabricating precision, miniature-size components suitable for use in accelerator physics and commercial applications. The original R&D work at Argonne, in collaboration with the University of Illinois at Chicago, has produced encouraging results in the area of rf accelerating structure design, optical and x-ray masks production, deep x-ray lithography (LIGA exposures), and precision structural alignments. In this paper we will present a design study for a compact single pass mm-linac FEL to produce short wavelength radiation. This system will consists of a photocathode rf gun operated at 30 GHz, a 50-MeV superconducting constant gradient structure operated at 60 GHz, and a microundulator with 1-mm period. Initial experimental results on a scale model rf gun and microundulator will be presented.

  6. Introduction to statistics using interactive MM*Stat elements

    CERN Document Server

    Härdle, Wolfgang Karl; Rönz, Bernd

    2015-01-01

    MM*Stat, together with its enhanced online version with interactive examples, offers a flexible tool that facilitates the teaching of basic statistics. It covers all the topics found in introductory descriptive statistics courses, including simple linear regression and time series analysis, the fundamentals of inferential statistics (probability theory, random sampling and estimation theory), and inferential statistics itself (confidence intervals, testing). MM*Stat is also designed to help students rework class material independently and to promote comprehension with the help of additional examples. Each chapter starts with the necessary theoretical background, which is followed by a variety of examples. The core examples are based on the content of the respective chapter, while the advanced examples, designed to deepen students’ knowledge, also draw on information and material from previous chapters. The enhanced online version helps students grasp the complexity and the practical relevance of statistical...

  7. 9th IFToMM International Conference on Rotor Dynamics

    CERN Document Server

    2015-01-01

    This book presents the proceedings of the 9th IFToMM International Conference on Rotor Dynamics. This conference is a premier global event that brings together specialists from the university and industry sectors worldwide in order to promote the exchange of knowledge, ideas, and information on the latest developments and applied technologies in the dynamics of rotating machinery. The coverage is wide ranging, including, for example, new ideas and trends in various aspects of bearing technologies, issues in the analysis of blade dynamic behavior,  condition monitoring of different rotating machines, vibration control, electromechanical and fluid-structure interactions in rotating machinery, rotor dynamics of micro, nano, and cryogenic machines, and applications of rotor dynamics in transportation engineering. Since its inception 32 years ago, the IFToMM International Conference on Rotor Dynamics has become an irreplaceable point of reference for those working in the field, and this book reflects the high qua...

  8. Udtrækning af 10 mm ankerbolte

    DEFF Research Database (Denmark)

    Hansen, Lars Pilegaard

    Denne rapport beskriver forsøg med udtrækning af 10 mm ankerbolte udført af Laboratoriet for Bærende Konstruktioner, Instituttet for Bygningsteknik, Aalborg Universitet. Forsøgene blev udført d. 19. og 21. juni 2001. Forsøgene blev udført dels på Hjørring Sygehus og dels på Laboratoriet.......Denne rapport beskriver forsøg med udtrækning af 10 mm ankerbolte udført af Laboratoriet for Bærende Konstruktioner, Instituttet for Bygningsteknik, Aalborg Universitet. Forsøgene blev udført d. 19. og 21. juni 2001. Forsøgene blev udført dels på Hjørring Sygehus og dels på Laboratoriet....

  9. Tracking chamber made of 15-mm mylar drift tubes

    Science.gov (United States)

    Kozhin, A.; Borisov, A.; Bozhko, N.; Fakhrutdinov, R.; Plotnikov, I.

    2017-05-01

    We are presenting a drift chamber composed from three layers of mylar drift tubes with outer diameter 15 mm. The pipe is made of strip of mylar film 125 micrometers thick covered with aluminium from the both sides. A strip of mylar is wrapped around the mandrel. Pipe is created by ultrasonic welding. A single drift tube is self-supported structure withstanding 350 g wire tension without supports and internal overpressure. About 400 such tubes were assembled. Design, quality control procedures of the drift tubes are described. Seven chambers were glued from these tubes of 560 mm length. Each chamber consists of 3 layers, 16 tubes per layer. Several chambers were tested with cosmic rays. Results of the tests, counting rate plateau and coordinate resolution are presented.

  10. Tracking chamber made of 15-mm mylar drift tubes

    International Nuclear Information System (INIS)

    Kozhin, A.; Borisov, A.; Bozhko, N.; Fakhrutdinov, R.; Plotnikov, I.

    2017-01-01

    We are presenting a drift chamber composed from three layers of mylar drift tubes with outer diameter 15 mm. The pipe is made of strip of mylar film 125 micrometers thick covered with aluminium from the both sides. A strip of mylar is wrapped around the mandrel. Pipe is created by ultrasonic welding. A single drift tube is self-supported structure withstanding 350 g wire tension without supports and internal overpressure. About 400 such tubes were assembled. Design, quality control procedures of the drift tubes are described. Seven chambers were glued from these tubes of 560 mm length. Each chamber consists of 3 layers, 16 tubes per layer. Several chambers were tested with cosmic rays. Results of the tests, counting rate plateau and coordinate resolution are presented.

  11. Animal experiments and clinical trials of {sup 166}Ho-chitosan for various cancers

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Sang Moo; Choi, C W; Kim, E H; Woo, K S; Chung, W S; Lee, J I; Park, S Y; Son, Y S; Lee, S H; Kim, S J; Kim, B G; Kim, J H; Lee, C H [Korea Cancer Center Hospital, Seoul (Korea, Republic of)

    1997-07-01

    {sup 166}Ho is a good therapeutic radionuclide because of its suitable half-life (26.8 hours), high beta energy and 6% gamma ray for imaging. Chitosan is a kind of N-glucosamine with 400 to 500 kD MW, which chelates metal ions and degrades slowly in vivo. As a preclinical studies, we performed cytotoxic effect of {sup 166}Ho-chitosan in a variety of cancer cell lines derived from stomach or ovarian cancer based on MTT assay and HTCA method. To evaluated the absorbed dose to the cavitary wall from {sup 166}Ho-chitosan, intraperitoneal administration of {sup 166}Ho-chitosan in the rat and simulation of energy transfer from the beta particles to the cavity wall using the Monte Carlo code EGS4 was done, and used as a standard for the planning therapy. Intracavitary {sup 166}Ho-chitosan therapy were tried in peritoneal metastatic ovarian and stomach cancers and cystic brain tumors. Intraarterial injection in inoperable primary liver cancer was also tried. As a radiation synovectomy agent, biocompatibility study in the knee joints of rabbits were performed. {sup 166}Ho-chitosan showed synergistic effects with 5-FU or cisplatin in vitro. 97-99% of {sup 166}Ho-chitosan was localized within the peritoneal cavity, and more than 90% of {sup 166}Ho-chitosan was attached to the peritoneal wall. Partial response were observed in 4 among 5 patients with ovarian cancer without severe toxicity. In the cystic brain tumor, 5 of 8 cysts were shrunken in size with thinning of the wall, 2 out of 8 showed growth retardation. In the primary liver cancer, radioactivity was distributed in the teritory of selected hepatic arterial branch, and partial responses were observed in 2 cases. In the knee joints of the rabbits, more than 98% of {sup 166}Ho-chitosan remained in the joint cavity and was stable upto 1 week. 49 refs., 22 tabs. (author)

  12. Fusion plasma diagnostics with mm-waves an introduction

    CERN Document Server

    Hartfuss, Hans-Jürgen

    2013-01-01

    Filling a gap in the literature, this introduction to the topic covers the physics of the standard microwave diagnostics established on modern fusion experiments, and the necessary technological background from the field of microwave engineering. Written by well-known mm-wave diagnosticians in the field of fusion physics, the textbook includes such major diagnostic techniques as electron cyclotron emission, interferometry, reflectometry, polarimetry, and scattering.

  13. 1st International Conference of IFToMM Italy

    CERN Document Server

    Gasparetto, Alessandro

    2017-01-01

    This volume contains the Proceedings of the First International Conference of IFToMM Italy (IFIT2016), held at the University of Padova, Vicenza, Italy, on December 1-2, 2016. The book contains contributions on the latest advances on Mechanism and Machine Science. The fifty-nine papers deal with such topics as biomechanical engineering, history of mechanism and machine science, linkages and mechanical controls, multi-body dynamics, reliability, robotics and mechatronics, transportation machinery, tribology, and vibrations.

  14. Cerenkov maser operation at lower-mm wavelengths

    International Nuclear Information System (INIS)

    Garate, E.; Cook, R.; Heim, P.; Layman, R.; Walsh, J.

    1985-01-01

    The basic operating principles of Cerenkov maser oscillators are briefly reviewed and the experimental performance of a 3-mm device is discussed. A power level of approximately 100 kW was achieved at 88 GHz and voltage tuning from 84 to 128 GHz on the fundamental TM 01 mode was observed. Operation on higher-order modes at frequencies up to 300--320 GHz was demonstrated, and a two-stage buncher-amplifier configuration was investigated

  15. Local Structure of Mn in (La1-xHox)2/3Ca1/3MnO3 Studied by X-ray Absorption Fine Structure

    International Nuclear Information System (INIS)

    Pietnoczka, A.; Bacewicz, R.; Antonowicz, J.; Zalewski, W.; Pekala, M.; Drozd, V.; Fagnard, J.F.; Vanderbemden, P.

    2010-01-01

    Results of X-ray absorption fine structure measurements in manganites (La 1-x Ho x ) 2/3 Ca 1/3 MnO 3 with 0.15 3 is doped with a divalent element such as Ca 2+ , substituting for La 3+ , holes are induced in the filled Mn d orbitals. This leads to a strong ferromagnetic coupling between Mn sites. Ca ions in La 1-x Ca x MnO 3 introduce a distortion of the crystal lattice and mixed valence Mn ions (Mn 3+ and Mn 4+ ). On the other hand, in manganites (La 1-x Ho x ) 2/3 Ca 1/3 MnO 3 the substitution of La for Ho causes a lattice distortion and induces a disorder, which reduces a magnetic interaction. The ferromagnetic transition temperature and conductivity decrease very quickly with increasing x. The magnetic and transport properties of compounds depend on the local atomic structure around Mn ions. The information on the bond lengths and Debye-Waller factor are obtained from the extended X-ray absorption fine structure (EXAFS) data analysis. The charge state of Mn is determined from the position of the absorption edge in X-ray absorption near edge structure (XANES) data. XAFS results are in good agreement with magnetic characteristics of the studied materials. (authors)

  16. Inositol phosphates influence the membrane bound Ca2+/Mg2+ stimulated ATPase from human erythrocyte membranes

    International Nuclear Information System (INIS)

    Kester, M.; Ekholm, J.; Kumar, R.; Hanahan, D.J.

    1986-01-01

    The modulation by exogenous inositol phosphates of the membrane Ca 2+ /Mg 2+ ATPase from saponin/EGTA lysed human erythrocytes was determined in a buffer (pH 7.6) containing histidine, 80 mM, MgCl 2 , 3.3 mM, NaCl, 74 mM, KCl, 30 mM, Na 2 ATP, 2.3 mM, ouabain, 0.83 mM, with variable amounts of CaCl 2 and EGTA. The ATPase assay was linear with time at 44 0 C. The inositol phosphates were commercially obtained and were also prepared from 32 P labeled rabbit platelet inositol phospholipids. Inositol triphosphate (IP 3 ) elevated the Ca 2+ /Mg 2+ ATPase activity over basal levels in a dose, time, and calcium dependent manner and were increased up to 85% of control values. Activities for the Na + /K + -ATPase and a Mg 2+ ATPase were not effected by IP 3 . Ca 2+ /Mg 2+ APTase activity with IP 2 or IP 3 could be synergistically elevated with calmodulin addition. The activation of the ATPase with IP 3 was calcium dependent in a range from .001 to .02 mM. The apparent Km and Vmax values were determined for IP 3 stimulated Ca 2+ /Mg 2+ ATPase

  17. Growth-inhibitory effects of a mineralized extract from the red marine algae, Lithothamnion calcareum, on Ca(2+)-sensitive and Ca(2+)-resistant human colon carcinoma cells.

    Science.gov (United States)

    Aslam, Muhammad Nadeem; Bhagavathula, Narasimharao; Paruchuri, Tejaswi; Hu, Xin; Chakrabarty, Subhas; Varani, James

    2009-10-08

    Proliferation and differentiation were assessed in a series of human colon carcinoma cell lines in response to a mineral-rich extract derived from the red marine algae, Lithothamnion calcareum. The extract contains 12% Ca2+, 1% Mg2+, and detectable amounts of 72 trace elements, but essentially no organic material. The red algae extract was as effective as inorganic Ca2+ alone in suppressing growth and inducing differentiation of colon carcinoma cells that are responsive to a physiological level of extracellular Ca2+ (1.4mM). However, with cells that are resistant to Ca2+ alone, the extract was still able to reduce proliferation and stimulate differentiation.

  18. Growth-inhibitory effects of a mineralized extract from the red marine algae, Lithothamnion calcareum, on Ca2+-sensitive and Ca2+-resistant human colon carcinoma cells

    Science.gov (United States)

    Nadeem Aslam, Muhammad; Bhagavathula, Narasimharao; Paruchuri, Tejaswi; Hu, Xin; Chakrabarty, Subhas; Varani, James

    2009-01-01

    Proliferation and differentiation were assessed in a series of human colon carcinoma cell lines in response to a mineral-rich extract derived from the red marine algae, Lithothamnion calcareum. The extract contains 12% Ca2+, 1% Mg2+, and detectable amounts of 72 trace elements, but essentially no organic material. The red algae extract was as effective as inorganic Ca2+ alone in suppressing growth and inducing differentiation of colon carcinoma cells that are responsive to a physiological level of extracellular Ca2+ (1.4 mM). However, with cells that are resistant to Ca2+ alone, the extract was still able to reduce proliferation and stimulate differentiation. PMID:19394137

  19. Magnetic and crystallographic properties of HoCo3B2

    International Nuclear Information System (INIS)

    Caspi, E.N.; Dubman, M.; Ettedgui, H.; Shaked, H.; Short, S.; Jorgensen, J.D.

    2005-01-01

    AC-susceptibility measurements for HoCo 3 B 2 show paramagnetism below room temperature and a small, and large anomalies at 150 and 10K, respectively. Neutron powder diffraction measurements show a ferromagnetic order below 10K, where the ferromagnetic Ho and Co sublattices are ferromagnetically coupled. The magnetic axis direction is perpendicular to the c axis. The observed magnitudes of the magnetic moments at 4.5K are 5.08(4) and 0.11(2) μ B for Ho and Co, respectively. No long range magnetic order was detected above 10K

  20. Development of Therapeutic Modality of Esophageal Cancer Using Ho-166 Stent

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jong Doo; Park, Kwang Kyun; Lee, Min Geol [Yonsei University Medical College, Seoul (Korea, Republic of); Park, Kyung Bae [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1997-09-01

    The prognosis of esophageal cancer is poor due absence of serosa which prevent local invasion to the surrounding organs such as aorta, mediastinum, trachea, and bronchi. We developed a Ho-166 Coated Radioactive Self-Expandable Metallic Stent which is a new herapeutic device in the treatment of esophageal cancer and underwent an animal experiment in mongrel dogs. We observed mucosal destruction by 4-6 mCi of Ho-166 without serious complications such as perforation of esophageal wall. Therefore, Ho-166 coated self-expandable stent appears to be an effective therapeutic device in the palliative treatment of esophageal cancer. 17 refs., 4 figs. (author)

  1. Temperature-induced spin reorientation and magnetization jump of rare-earth orthoferrite Ho{sub 0.5}Pr{sub 0.5}FeO{sub 3} single crystal

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Guohua; Zhao, Weiyao; Cao, Yiming; Kang, Baojuan [Department of Physics, and International Center of Quantum and Molecular Structures, Shanghai University, Shanghai 200444 (China); Zhang, Jincang [Department of Physics, and International Center of Quantum and Molecular Structures, Shanghai University, Shanghai 200444 (China); Materials Genome Institute, Shanghai University, Shanghai 200444 (China); Shanghai Key Laboratory of High Temperature Superconductors, Shanghai University, Shanghai 200444 (China); Ren, Wei, E-mail: renwei@shu.edu.cn [Department of Physics, and International Center of Quantum and Molecular Structures, Shanghai University, Shanghai 200444 (China); Materials Genome Institute, Shanghai University, Shanghai 200444 (China); Shanghai Key Laboratory of High Temperature Superconductors, Shanghai University, Shanghai 200444 (China); Cao, Shixun, E-mail: sxcao@shu.edu.cn [Department of Physics, and International Center of Quantum and Molecular Structures, Shanghai University, Shanghai 200444 (China); Materials Genome Institute, Shanghai University, Shanghai 200444 (China); Shanghai Key Laboratory of High Temperature Superconductors, Shanghai University, Shanghai 200444 (China)

    2016-07-25

    We report temperature-induced spin reorientation and magnetization jump effects in the rare earth (RE) orthoferrite Ho{sub 0.5}Pr{sub 0.5}FeO{sub 3} single crystal. The single crystal of about 6 mm in diameter and 50 mm in length was successfully grown by optical floating zone method. Both X-ray diffraction and Laue photograph confirmed the homogeneity and high quality of the crystal. Magnetic properties of Ho{sub 0.5}Pr{sub 0.5}FeO{sub 3} single crystal are studied over a wide temperature range from 2 to 300 K. Spin reorientation transition from Γ{sub 2} to Γ{sub 4} phase is observed in the temperature range of 75–90 K. At lower temperature, the Ho{sub 0.5}Pr{sub 0.5}FeO{sub 3} shows an abrupt jump of magnetization along the a-axis, which occurs only in the field-cooling process, and is sensitive to external applied magnetic field. By analyzing the jump temperature and magnitude of the magnetization, we conclude that it is caused by the spin reversal of the rare earth ions. The isothermal magnetization versus field hysteresis loop measurements along a axis explain the spin configuration variation from 3 K to 60 K. - Highlights: • Ho{sub 0.5}Pr{sub 0.5}FeO{sub 3} single crystal was grown by optical floating zone method. • It shows an abrupt jump of magnetization along a axis at low temperature. • The jump height and temperature is sensitive to external applied magnetic field. • It is attributed to the spin reversal of the rare earth ions.

  2. Ho3+-doped AlF3-TeO2-based glass fibers for 2.1 µm laser applications

    Science.gov (United States)

    Wang, S. B.; Jia, Z. X.; Yao, C. F.; Ohishi, Y.; Qin, G. S.; Qin, W. P.

    2017-05-01

    Ho3+-doped AlF3-TeO2-based glass fibers based on AlF3-BaF2-CaF2-YF3-SrF2-MgF2-TeO2 glasses are fabricated by using a rod-in-tube method. The glass rod including a core and a thick cladding layer is prepared by using a suction method, where the thick cladding layer is used to protect the core from the effect of surface crystallization during the fiber drawing. By inserting the glass rod into a glass tube, the glass fibers with relatively low loss (~2.3 dB m-1 @ 1560 nm) are prepared. By using a 38 cm long Ho3+-doped AlF3-TeO2-based glass fiber as the gain medium and a 1965 nm fiber laser as the pump source, 2065 nm lasing is obtained for a threshold pump power of ~220 mW. With further increasing the pump power to ~325 mW, the unsaturated output power of the 2065 nm laser is about 82 mW and the corresponding slope efficiency is up to 68.8%. The effects of the gain fiber length on the lasing threshold, the slope efficiency, and the operating wavelength are also investigated. Our experimental results show that Ho3+-doped AlF3-TeO2-based glass fibers are promising gain media for 2.1 µm laser applications.

  3. HTS Nested magnet wound with 12 mm GdBCO tape and 4.4 mm YBCO tape

    International Nuclear Information System (INIS)

    Kang, Myung Hun; Ku, Myung Hwan; Cha, Guee Soo; Lim, Hyoung Woo

    2015-01-01

    The properties of High Temperature Superconducting (HTS) tapes are progressing, as HTS tapes evolve from 1st generation to 2nd generation. This paper presents design and construction of a 2nd generation HTS magnet consisting of two nested GdBCO and YBCO pancake coils. Two HTS tapes of different widths were used to wind the HTS nested magnet. Considering that a higher magnetic field is applied to the inner magnet than to the outer magnet, 12 mm GdBCO tape was used for winding the inner magnet, which consisted of four single pancake windings. Eight double pancake windings wound with 4.4 mm YBCO tapes were used for the outer magnet. The test results show that the central magnetic field of the HTS nested magnet was 920 mT. The measured critical currents of the inner and outer magnet at 77K were 80.8 A and 32.6 A, respectively

  4. Results from a partial lifetime test of a 40 mm-aperture 17 mm SSC model dipole

    International Nuclear Information System (INIS)

    Radusewicz, P.; Devred, A.; Bush, T.; Coombes, R.; DiMarco, J.; Goodzeit, C.; Kuzminski, J.; Ogitsu, T.; Potter, J.; Puglisi, M.; Sanger, P.; Schermer, R.; Tompkins, J.; Yu, Y.; Zhao, Y.; Zheng, H.; Anerella, M.; Cottingham, J.; Ganetis, G.; Garber, M.; Ghosh, A.; Greene, A.; Gupta, R.; Jain, A.; Kahn, S.; Kelly, E.; Morgan, G.; Muratore, J.; Prodell, A.; Rehak, M.; Roher, E.P.; Sampson, W.; Shutt, R.; Thomas, R.; Thompson, P.; Wanderer, P.; Willen, E.; Bleadon, M.; Hanft, R.; Kuchnir, M.; Mantsch, P.; Mazur, P.O.; Orris, D.; Peterson, T.; Strait, J.; Royett, J.; Scanlan, R.; Taylor, C.

    1992-03-01

    A 40-mm-aperture, 17-m-long Superconducting Super Collider (SSC) model dipole was assembled at Brookhaven National Laboratory (BNL) and tested initially at Fermi National Accelerator Lab (FNAL) and later at BNL. At BNL an extended cycle test was devised to examine the magnet's performance through numerous cold tests and thermal cycles. This paper discusses the magnet's mechanical and quench performance and magnet field measurements during the tests

  5. Řízení procesu reaktivního magnetronového naprašování

    OpenAIRE

    Dušek, Jan

    2014-01-01

    Bakalářská práce stručně popisuje technologii reaktivního magnetronového naprašování a zabývá se návrhem a realizací programu k jeho ovládání. K tomuto účelu byl vytvořen ovládací program pro řízení jednotlivých komponent aparatury PLS160 v programovacím prostředí LabView. Na základě znalostí technologického procesu a postupu reaktivního magnetronového naprašování byl vytvořen automatický program. Tento automatický program je možné modifikovat pomocí receptů. Vedle programové skladby byly pro...

  6. Modulation of intracellular calcium waves and triggered activities by mitochondrial ca flux in mouse cardiomyocytes.

    Directory of Open Access Journals (Sweden)

    Zhenghang Zhao

    Full Text Available Recent studies have suggested that mitochondria may play important roles in the Ca(2+ homeostasis of cardiac myocytes. However, it is still unclear if mitochondrial Ca(2+ flux can regulate the generation of Ca(2+ waves (CaWs and triggered activities in cardiac myocytes. In the present study, intracellular/cytosolic Ca(2+ (Cai (2+ was imaged in Fluo-4-AM loaded mouse ventricular myocytes. Spontaneous sarcoplasmic reticulum (SR Ca(2+ release and CaWs were induced in the presence of high (4 mM external Ca(2+ (Cao (2+. The protonophore carbonyl cyanide p-(trifluoromethoxyphenylhydrazone (FCCP reversibly raised basal Cai (2+ levels even after depletion of SR Ca(2+ in the absence of Cao (2+ , suggesting Ca(2+ release from mitochondria. FCCP at 0.01 - 0.1 µM partially depolarized the mitochondrial membrane potential (Δψ m and increased the frequency and amplitude of CaWs in a dose-dependent manner. Simultaneous recording of cell membrane potentials showed the augmentation of delayed afterdepolarization amplitudes and frequencies, and induction of triggered action potentials. The effect of FCCP on CaWs was mimicked by antimycin A (an electron transport chain inhibitor disrupting Δψ m or Ru360 (a mitochondrial Ca(2+ uniporter inhibitor, but not by oligomycin (an ATP synthase inhibitor or iodoacetic acid (a glycolytic inhibitor, excluding the contribution of intracellular ATP levels. The effects of FCCP on CaWs were counteracted by the mitochondrial permeability transition pore blocker cyclosporine A, or the mitochondrial Ca(2+ uniporter activator kaempferol. Our results suggest that mitochondrial Ca(2+ release and uptake exquisitely control the local Ca(2+ level in the micro-domain near SR ryanodine receptors and play an important role in regulation of intracellular CaWs and arrhythmogenesis.

  7. Experimental application of pulsed Ho:YAG laser-induced liquid jet as a novel rigid neuroendoscopic dissection device.

    Science.gov (United States)

    Ohki, Tomohiro; Nakagawa, Atsuhiro; Hirano, Takayuki; Hashimoto, Tokitada; Menezes, Viren; Jokura, Hidefumi; Uenohara, Hiroshi; Sato, Yasuhiko; Saito, Tsutomu; Shirane, Reizo; Tominaga, Teiji; Takayama, Kazuyoshi

    2004-01-01

    Although water jet technology has been considered as a feasible neuroendoscopic dissection methodology because of its ability to perform selective tissue dissection without thermal damage, problems associated with continuous use of water and the ensuing fountain-effect-with catapulting of the tissue-could make water jets unsuitable for endoscopic use, in terms of safety and ease of handling. Therefore, the authors experimented with minimization of water usage during the application of a pulsed holmium:yttrium-aluminum-garnet (Ho:YAG) laser-induced liquid jet (LILJ), while assuring the dissection quality and the controllability of a conventional water jet dissection device. We have developed the LILJ generator for use as a rigid neuroendoscope, discerned its mechanical behavior, and evaluated its dissection ability using the cadaveric rabbit ventricular wall. The LILJ generator is incorporated into the tip of a stainless steel tube (length: 22 cm; internal diameter: 1.0 mm; external diameter: 1.4 mm), so that the device can be inserted into a commercial, rigid neuroendoscope. Briefly, the LILJ is generated by irradiating an internally supplied water column within the stainless steel tube using the pulsed Ho:YAG laser (wave length: 2.1 microm, pulse duration time: 350 microseconds) and is then ejected through the metal nozzle (internal diameter: 100 microm). The Ho:YAG laser pulse energy is conveyed through optical quartz fiber (core diameter: 400 microm), while cold water (5 degrees C) is internally supplied at a rate of 40 ml/hour. The relationship between laser energy (range: 40-433 mJ/pulse), standoff distance (defined as the distance between the tip of the optical fiber and the nozzle end; range: 10-30 mm), and the velocity, shape, pressure, and average volume of the ejected jet were analyzed by means of high-speed camera, PVDF needle hydrophone, and digital scale. The quality of the dissection plane, the preservation of blood vessels, and the penetration depth

  8. High-pressure phase transition in Ho2O3

    International Nuclear Information System (INIS)

    Lonappan, Dayana; Shekar, N.V. Chandra; Ravindran, T.R.; Sahu, P. Ch.

    2010-01-01

    High-pressure X-ray diffraction and Raman studies on holmium sesquioxide (Ho 2 O 3 ) have been carried out up to a pressure of ∼17 GPa in a diamond-anvil cell at room temperature. Holmium oxide, which has a cubic or bixbyite structure under ambient conditions, undergoes an irreversible structural phase transition at around 9.5 GPa. The high-pressure phase has been identified to be low symmetry monoclinic type. The two phases coexist to up to about 16 GPa, above which the parent phase disappears. The high-pressure laser-Raman studies have revealed that the prominent Raman band ∼370 cm -1 disappears around the similar transition pressure. The bulk modulus of the parent phase is reported.

  9. Distribuce digitálního obsahu

    OpenAIRE

    Voborník, Vojtěch

    2016-01-01

    Bakalářská práce reaguje na současné způsoby distribuce digitálního obsahu na internetu (například audia, videa, softwaru, videoher, e-knih, fotografií apod.) mezi autorem a spotřebitelem, jejich výhody a nevýhody a nabízí alternativní způsob distribuce dosud nezveřejněných digitálních děl, prostřednictvím vytvořené webové stránky, která je výstupem této práce. Bachelor thesis responds to the current distribution methods of digital content on the internet (for example, audio, video, softwa...

  10. End design of the SSC 58 mm High Gradient Quadrupole

    International Nuclear Information System (INIS)

    Caspi, S.

    1992-01-01

    The ''end'' design of the High Gradient Quad. was done with consideration to the integrated field harmonics, the iron contribution, and the maximum field at the conductor. Magnetic analysis was done on the return end only, however the physical dimension of the lead end were determined as well. Using the cross-section of the windings and Cook's program BEND, we generated the physical end windings around the return end. Placing a single wire at the center of each turn the integrated gradient was computed and iterating on the end block spacers the integrated harmonics minimized. The final geometry was then used for more, extensive calculations, such as the field at the conductor and the 3D field harmonics. For this detailed calculation we have placed a single line current at the center of each strand and included the iron contribution (μ = ∞), see Appendix C. With the termination of the iron serving as a reference, the maximum length of the inner and outer layers are 182 mm and 215 mm respectively. The magnetic length of the end was computed from the gradient function A 2 and was found to be 142 mm. In reality we expect the physical length of the end to be somewhat larger, however this should have little or no effect on the magnetic length. The gradient in the straight section is 212.44 T/m at 7000 A and the integrated value of the gradient is -3.01665 E5 (G) in the end region marked by the magnetic length of the end. The respective integrated harmonics for the end 12 pole and 20 pole are -10.6658 (G/CM 4 ) and 0.7279 (G/cm 8 ) corresponding to b 6 = 0.351 , b 10 = -0.024 units. The above was computed from the values of A 2 , A 6 , and A 10

  11. Advanced accelerator and mm-wave structure research at LANL

    Energy Technology Data Exchange (ETDEWEB)

    Simakov, Evgenya Ivanovna [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-06-22

    This document outlines acceleration projects and mm-wave structure research performed at LANL. The motivation for PBG research is described first, with reference to couplers for superconducting accelerators and structures for room-temperature accelerators and W-band TWTs. These topics are then taken up in greater detail: PBG structures and the MIT PBG accelerator; SRF PBG cavities at LANL; X-band PBG cavities at LANL; and W-band PBG TWT at LANL. The presentation concludes by describing other advanced accelerator projects: beam shaping with an Emittance Exchanger, diamond field emitter array cathodes, and additive manufacturing of novel accelerator structures.

  12. Living with Omniback and the 8mm drive

    Energy Technology Data Exchange (ETDEWEB)

    Jones, M.C.

    1990-01-01

    Apollo's OmniBack backup system provides a convenient and effective way of storing network backup information on 8mm tape. In addition it has a journaling facility to write extensive log files, recording the backup process in almost any degree of detail desired. The directory structure and file names used are logical and well-defined. Summary files announce the degree of success of the backup as specified in the work file. The system will run unattended under the UNIX cron command, allowing the backup to be performed during the night when user demands on the network are small and most user files are free.

  13. Solubility of calcium in CaO-CaCl2

    International Nuclear Information System (INIS)

    Perry, G.S.; Shaw, S.J.

    1991-06-01

    The Direct Oxide Reduction (DOR) process is well established as a process to produce plutonium metal from plutonium dioxide by reaction with calcium. Calcium chloride is added to dissolve the calcium oxide produced, allowing the metal to coalesce into a button. Since calcium metal melts at 840 0 C and DOR can take place successfully below this temperature, it is likely calcium dissolved in calcium chloride reacts with the plutonium dioxide. The solubility of calcium in calcium chloride is reasonably well established but the effect of the CaO formed during the DOR process on the solubility of calcium has not been previously determined. For this reason the solubility of calcium in CaCl 2 -CaO melts at 800 o C has been studied. The solubility decreases from 2.7 mol % in CaCl 2 to 0.4 mol % in 9 mol % CaO-CaCl 2 . (author)

  14. Polyamines as mediators of insulin's action on pyruvate dehydrogenase, 45Ca2+ fluxes, and membrane transport

    International Nuclear Information System (INIS)

    Goldstone, A.D.; Koenig, H.; Lu, C.Y.

    1986-01-01

    Insulin (IN) induces a rapid stimulation of Ca 2+ fluxes and membrane transport in mouse kidney cortex which involves rapid polyamine synthesis. 1.3 nM (IN) induced an early ( 45 Ca 2+ influx and efflux peaked at 1-2 min and returned to basal levels by 5-10 min. The ODC inhibitor α-difluoromethylornithine (DFMO, 5 mM) abolished IN stimulation of PDH, 45 Ca 2+ fluxes and membrane transport, and putrescine (.5 mM) nullified DFMO inhibition. IN (50 mUnits/kg) in rats induced an early ( 2+ fluxes, and membrane transport

  15. Positive parity states in 153Ho and the question of shape coexistence

    International Nuclear Information System (INIS)

    Chakraborty, A.; Ray, Sudatta; Ray, I.; Pradhan, M.K.; Raut, R.; Goswami, A.; Banerjee, P.; Mukherjee, A.; Bhattacharya, S.; Saha Sarkar, M.; Dey, Gautam; Krishichayan; Kshetri, Ritesh; Ganguly, S.; Ray Basu, M.; Ganguly, G.; Ghugre, S.S.; Sinha, A.K.; Basu, S.K.; Sarkar, S.

    2008-01-01

    In the present work the existing level scheme have been extended from the experimental data and studied specifically the positive parity states in 153 Ho theoretically to understand the issue of shape coexistence in this nucleus

  16. Magnetocaloric properties of the hexagonal HoMnO{sub 3} single crystal revisited

    Energy Technology Data Exchange (ETDEWEB)

    Balli, M., E-mail: Mohamed.balli@Usherbrooke.ca [Regroupement québécois sur les matériaux de pointe, Département de physique, Université de Sherbrooke, QC, Canada J1K 2R1 (Canada); Roberge, B.; Vermette, J.; Jandl, S. [Regroupement québécois sur les matériaux de pointe, Département de physique, Université de Sherbrooke, QC, Canada J1K 2R1 (Canada); Fournier, P. [Regroupement québécois sur les matériaux de pointe, Département de physique, Université de Sherbrooke, QC, Canada J1K 2R1 (Canada); Canadian Institute for Advanced Research, Toronto, Ontario, Canada M5G 1Z8 (Canada); Gospodinov, M.M. [Institute of Solid State Physics, Bulgarian Academy of Science, Sofia 1184 (Bulgaria)

    2015-12-01

    Magnetic and magnetocaloric properties of the hexagonal HoMnO{sub 3} single crystal have been revisited. It was found that the magnetocaloric effect shown by HoMnO{sub 3} strongly depends on the crystal orientation in respect to the applied magnetic field. Consequently, a large thermal effect can be induced by spinning the single crystal HoMnO{sub 3} around the a (or b) axis in a constant magnetic field instead of the conventional magnetization–demagnetization process. Under 7 T, the maximum rotating entropy change was evaluated to be about 8 J/kg K. The associated adiabatic temperature change reaches a value of about 5 K. These values are comparable to those of the other oxides exhibiting a large rotating magnetocaloric effect. The presence of both conventional and rotating thermal effects makes the hexagonal HoMnO{sub 3} more interesting from a practical point of view.

  17. High Power Narrow Linewidth 1.26 Micron Ho-Doped Fiber Amplifier, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposal is for the development of an innovative, high power, and extremely reliable 1.26-micron Ho-doped fluoride fiber amplifier. The proposed fiber amplifier...

  18. High Power Narrow Linewidth 1.26 Micron Ho-Doped Fiber Amplifier, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposal is for the development of an innovative, high power, and extremely reliable 1.26-micron Ho-doped fluoride fiber amplifier. The proposed fiber amplifier...

  19. In situ measurements of HO{sub x} in super- and subsonic aircraft exhaust plumes

    Energy Technology Data Exchange (ETDEWEB)

    Hanisco, T F; Wennberg, P O; Cohen, R C; Anderson, J G [Harvard Univ., Cambridge, MA (United States). Dept. of Chemistry; Fahey, D W; Keim, E R; Gao, R S; Wamsley, R C; Donnelly, S G; Del Negro, L A [National Oceanic and Atmospheric Administration, Boulder, CO (United States). Aeronomy Lab.; others, and

    1998-12-31

    Concentrations of HO{sub x} (OH and HO{sub 2}) have been obtained in the exhaust plumes of an Air France Concorde and a NASA ER-2 in the lower stratosphere and the NASA DC-8 in the upper troposphere using instruments aboard the NASA ER-2. These fast-time response in situ measurements are used in conjunction with simultaneous in situ measurements of other key exhaust species (NO, NO{sub 2}, NO{sub y}, H{sub 2}O, and CO) to analyze the emissions of HO{sub x} from each aircraft under a variety of conditions. The data are used to establish a general description of gas phase plume chemistry that is easily implemented in a photochemical model. This model is used to determine the amount of HO{sub x} emitted from the engines and the gas phase oxidation rates of nitrogen and sulfur species in the exhaust plumes. (author) 10 refs.

  20. Technical cooperation for the wider uses of Ho-166 therapeutic agents in European countries

    CERN Document Server

    Park, K B; Choi, S M; Han, K H; Hong, Y D; Park, W W; Shin, B C

    2002-01-01

    Czech has put their priority in developing the radiopharmaceuticals based on reactor produced Ho-166 and a related fabrication will be extended to other EU conturies including Germany, France, etc after a development of project. The collaboration will be based on the mutual agreement for developing the between research institutes, industries and academic institutes and further researches should be followed by the issue of developing radiopharmaceuticals using Ho-166. To strengthen the collaboration, detailed discussions for the practical collaboration have been made through the visitation to the research institution of each counter part. For implementing the collaboration between NPI and KAERI, an institutional basis technical cooperation agreement(TCA) will be concluded. Furthermore, agreement for the substantial collaboration on Ho-166 related researches will be made after the conclusion of the TCA. It will accelerate the commercialization of KAERI developed Ho-166 therapeutic agents into other European cou...

  1. In situ measurements of HO{sub x} in super- and subsonic aircraft exhaust plumes

    Energy Technology Data Exchange (ETDEWEB)

    Hanisco, T.F.; Wennberg, P.O.; Cohen, R.C.; Anderson, J.G. [Harvard Univ., Cambridge, MA (United States). Dept. of Chemistry; Fahey, D.W.; Keim, E.R.; Gao, R.S.; Wamsley, R.C.; Donnelly, S.G.; Del Negro, L.A. [National Oceanic and Atmospheric Administration, Boulder, CO (United States). Aeronomy Lab.; and others

    1997-12-31

    Concentrations of HO{sub x} (OH and HO{sub 2}) have been obtained in the exhaust plumes of an Air France Concorde and a NASA ER-2 in the lower stratosphere and the NASA DC-8 in the upper troposphere using instruments aboard the NASA ER-2. These fast-time response in situ measurements are used in conjunction with simultaneous in situ measurements of other key exhaust species (NO, NO{sub 2}, NO{sub y}, H{sub 2}O, and CO) to analyze the emissions of HO{sub x} from each aircraft under a variety of conditions. The data are used to establish a general description of gas phase plume chemistry that is easily implemented in a photochemical model. This model is used to determine the amount of HO{sub x} emitted from the engines and the gas phase oxidation rates of nitrogen and sulfur species in the exhaust plumes. (author) 10 refs.

  2. Characterization of low temperature metallic magnetic calorimeters having gold absorbers with implanted $^{163}$Ho ions

    CERN Document Server

    Gastaldo, L.; von Seggern, F.; Porst, J.-P.; Schäfer, S.; Pies, C.; Kempf, S.; Wolf, T.; Fleischmann, A.; Enss, C.; Herlert, A.; Johnston, K.

    2013-01-01

    For the first time we have investigated the behavior of fully micro-fabricated low temperature metallic magnetic calorimeters (MMCs) after undergoing an ion-implantation process. This experiment had the aim to show the possibility to perform a high precision calorimetric measurement of the energy spectrum following the electron capture of $^{163}$Ho using MMCs having the radioactive $^{163}$Ho ions implanted in the absorber. The implantation of $^{163}$Ho ions was performed at ISOLDE-CERN. The performance of a detector that underwent an ion-implantation process is compared to the one of a detector without implanted ions. The results show that the implantation dose of ions used in this experiment does not compromise the properties of the detector. In addition an optimized detector design for future $^{163}$Ho experiments is presented.

  3. Podnikatelský plán pro transformaci rodinného podniku

    OpenAIRE

    Paníček, Roman

    2011-01-01

    Diplomová práce se zabývá transformací rodinného podniku z obchodního centra na taneční klub. Jedná se zde o kompletní analýzu vnitřního i vnějšího prostředí a z ní vyvozené závěry. Práce obsahuje zdroje financování, celkové náklady a odhadovaný vývoj do budoucna. Dále zde nalezneme marketingový mix a harmonogram implementace. This diploma thesis deals with the transformation of the family business from the commercial center to the dance club. Its mean that it contains complete analysis of...

  4. Prompt HO2 formation following the reaction of OH with aromatic compounds under atmospheric conditions.

    Science.gov (United States)

    Nehr, Sascha; Bohn, Birger; Wahner, Andreas

    2012-06-21

    The secondary formation of HO(2) radicals following OH + aromatic hydrocarbon reactions in synthetic air under normal pressure and temperature was investigated in the absence of NO after pulsed production of OH radicals. OH and HO(x) (=OH + HO(2)) decay curves were recorded using laser-induced fluorescence after gas-expansion. The prompt HO(2) yields (HO(2) formed without preceding NO reactions) were determined by comparison to results obtained with CO as a reference compound. This approach was recently introduced and applied to the OH + benzene reaction and was extended here for a number of monocyclic aromatic hydrocarbons. The measured HO(2) formation yields are as follows: toluene, 0.42 ± 0.11; ethylbenzene, 0.53 ± 0.10; o-xylene, 0.41 ± 0.08; m-xylene, 0.27 ± 0.06; p-xylene, 0.40 ± 0.09; 1,2,3-trimethylbenzene, 0.31 ± 0.06; 1,2,4-trimethylbenzene, 0.37 ± 0.09; 1,3,5-trimethylbenzene, 0.29 ± 0.08; hexamethylbenzene, 0.32 ± 0.08; phenol, 0.89 ± 0.29; o-cresol, 0.87 ± 0.29; 2,5-dimethylphenol, 0.72 ± 0.12; 2,4,6-trimethylphenol, 0.45 ± 0.13. For the alkylbenzenes HO(2) is the proposed coproduct of phenols, epoxides, and possibly oxepins formed in secondary reactions with O(2). In most product studies the only quantified coproducts were phenols whereas only a few studies reported yields of epoxides. Oxepins have not been observed so far. Together with the yields of phenols from other studies, the HO(2) yields determined in this work set an upper limit to the combined yields of epoxides and oxepins that was found to be significant (≤0.3) for all investigated alkylbenzenes except m-xylene. For the hydroxybenzenes the currently proposed HO(2) coproducts are dihydroxybenzenes. For phenol and o-cresol the determined HO(2) yields are matching the previously reported dihydroxybenzene yields, indicating that these are the only HO(2) forming reaction channels. For 2,5-dimethylphenol and 2,4,6-trimethylphenol no complementary product studies are available.

  5. The atomic structure of protons and hydrides in Sm1.92Ca0.08Sn2O7-δ pyrochlore from DFT calculations and FTIR spectroscopy

    DEFF Research Database (Denmark)

    Bork, Nicolai Christian; Eurenius, K. E. J.; Rossmeisl, Jan

    2012-01-01

    A combined density functional theory and Fourier transform infrared spectroscopy study of the structure and specific site preference of protons and hydrides in the pyrochlore Sm1.92Ca0.08Sn2O7-δ is presented. Two protonic sites of particular high stability are identified, both located on O(1......) oxygen atoms closely associated with a Ca dopant. Further, the unexpected presence of Ho hydride defects in undoped, oxygen deficient Sm2Sn2O7 is reported. Finally, the stretching frequencies and relative intensities for these and other sites are calculated. The main features of the Fourier transform...

  6. Stress relaxation in SSC 50mm dipole coils

    International Nuclear Information System (INIS)

    Rogers, D.; Markley, F.

    1992-04-01

    We are measuring the stress relaxation of SSC 50mm outer coils with the goal of predicting how much of the coil prestress will be lost while the coils are warehoused between manufacture and cooldown. We manufacture 3 inch (76.2mm) long segments of coil with the same materials and techniques that have been used for prototype coils. We are running four simultaneous tests in an attempt to separate the contributions of the different coil materials. Test one is a completely insulated coil section where the insulation is the all polyamide system being tested at Brookhaven; test two is a wire stack insulated only with the normal Kapton overwrap; test three is a stack of bare cable; and test four is a completely insulated normal coil section. All, except for the bare cable, include the ground insulation. The insulated coil sections are carefully dried before loading and testing in order to eliminate stress changes due to varying moisture content. The temperature dependence of the stress relaxation is being studied separately. Three companion papers presented at this conference will be: (1) ''Temperature dependence of the viscoelastic properties of SSC coil insulation'' (2) ''Measurement of the elastic modulus of Kapton perpendicular to the plane of the film at room and cryogenic temperatures'' (3) ''Theoretical methods for creep and stress relaxation studies of SSC coil.''

  7. QM/MM Molecular Dynamics Studies of Metal Binding Proteins

    Directory of Open Access Journals (Sweden)

    Pietro Vidossich

    2014-07-01

    Full Text Available Mixed quantum-classical (quantum mechanical/molecular mechanical (QM/MM simulations have strongly contributed to providing insights into the understanding of several structural and mechanistic aspects of biological molecules. They played a particularly important role in metal binding proteins, where the electronic effects of transition metals have to be explicitly taken into account for the correct representation of the underlying biochemical process. In this review, after a brief description of the basic concepts of the QM/MM method, we provide an overview of its capabilities using selected examples taken from our work. Specifically, we will focus on heme peroxidases, metallo-β-lactamases, α-synuclein and ligase ribozymes to show how this approach is capable of describing the catalytic and/or structural role played by transition (Fe, Zn or Cu and main group (Mg metals. Applications will reveal how metal ions influence the formation and reduction of high redox intermediates in catalytic cycles and enhance drug metabolism, amyloidogenic aggregate formation and nucleic acid synthesis. In turn, it will become manifest that the protein frame directs and modulates the properties and reactivity of the metal ions.

  8. Separation and Recycling for Rare Earth Elements by Homogeneous Liquid-Liquid Extraction (HoLLE Using a pH-Responsive Fluorine-Based Surfactant

    Directory of Open Access Journals (Sweden)

    Shotaro Saito

    2015-08-01

    Full Text Available A selective separation and recycling system for metal ions was developed by homogeneous liquid-liquid extraction (HoLLE using a fluorosurfactant. Sixty-two different elemental ions (e.g., Ag, Al, As, Au, B, Ba, Be, Bi, Ca, Cd, Ce, Co, Cr, Cu, Dy, Er, Eu, Fe, Ga, Gd, Ge, Hf, Hg, Ho, In, Ir, La, Lu, Mg, Mn, Mo, Nb, Nd, Ni, Os, P, Pb, Pd, Pr, Pt, Re, Rh, Ru, Sb, Sc, Se, Si, Sm, Sn, Sr, Ta, Tb, Te, Ti, Tl, Tm, V, W, Y, Yb, Zn, and Zr were examined. By changing pH from a neutral or alkaline solution (pH ≥ 6.5 to that of an acidic solution (pH < 4.0, gallium, zirconium, palladium, silver, platinum, and rare earth elements were extracted at >90% efficiency into a sedimented Zonyl FSA® (CF3(CF2n(CH22S(CH22COOH, n = 6–8 liquid phase. Moreover, all rare earth elements were obtained with superior extraction and stripping percentages. In the recycling of rare earth elements, the sedimented phase was maintained using a filter along with a mixed solution of THF and 1 M sodium hydroxide aqueous solution. The Zonyl FSA® was filtrated and the rare earth elements were recovered on the filter as a hydroxide. Furthermore, the filtrated Zonyl FSA was reusable by conditioning the subject pH.

  9. 166 Ho-HA Evaluation as therapeutic agent for rheumatoid arthritis treatment

    International Nuclear Information System (INIS)

    Chandia, M; Errazu, X; Mendoza, P; Troncoso, F; Jofre, J; Sierralta, P

    2003-01-01

    Aim: Rheumatoid arthritis is a limiting disease having, among its pathological features, the inflammation of synovial tissue with progressive and later destruction of the articulation. This lead to joint deformation and loss of its function, generating pain and reducing the mobility of the affected articulation. The aim was to evaluate 166 Ho-Hydroxyapatite ( 166 Ho-HA) as potential radiopharmaceutical for the syntomatic treatment of chronic and acute arthritis Materials and Methods: 166 Holmiun was produced by irradiation of Ho 2 O 3 at La Reina Research Reactor, Nuclear Chilean Energy Commission. Hydroxyapatite was in-house synthetized. Its labelling and quality controls follows the internationally accepted procedures. An antigen arthritis was induced to eight New Zealand rabbits with the 166 Ho-HA radiochemical being administred thereafter in two dosage modalities (single and double). The compound therapeutic efficiency was evaluated based upon clinical improvement and images from the inflamated articulation using 67 Ga citrate before and after 166 Ho-HA injection. Results: The radiochemical purity of the innoculated compound was greater than 98% as measured under sterility conditions. Clinically, an inflamation reduction (2 cm), appetite improvement and general well being was observed. The 166 Ho-HA distribution and localization was monitored using gamma camera images taken at 4 and 24 h. There was no evidence of extraarticular leakage. From the 67 Ga citrate imaging, the acute group shows an overall improvement of well being corresponding to a lesser uptake at the inflamated articulation, regarding to the chronic group. The 166 Ho-HA double dosis, compared to the single dosis, suggest a reduced uptake of 67 Ga citrate at the inflamated tissue, meaning an increased therapeutic effect. Conclusions: 166 Ho-HA is usefull as therapeutic agent for the syntomatic treatment of rheumatoideal arthritis as shown by imaging and clinical examination (author)

  10. 166Ho-HA evaluation as therapeutic agent for rheumatoid arthritis treatment

    International Nuclear Information System (INIS)

    Chandia, M.C.; Errazu, X.C.; Pinto, L.N.; Godoy, N.O.; Avila, M.J.; Mendoza, P.; Mendoza, J.; Jofre, J.; Sirraalta, P.

    2002-01-01

    Aim: Rheumatoid arthritis is a limiting disease having, among its pathological features, the inflammation of synovial tissue with progressive and later destruction of the articulation. This leads to joint deformation and loss of its function, generating pain and reducing the mobility of the affected articulation. The aim was to evaluate 166 Ho-Hydroxyapatite ( 166 Ho-HA) as potential radiopharmaceutical for the symptomatic treatment of chronic and acute arthritis. Materials and Methods: Holmiun-166 was produced by irradiation of Ho 2 O 3 at La Reina Research Reactor, Nuclear Chilean Energy Commission. Hydroxyapatite was in-house synthesized. Its labelling and quality controls follows the internationally accepted procedures. An antigen's arthritis was induced to eight New Zealand rabbits with the 166 Ho-HA radiochemical being administered thereafter in two dosage modalities (single and double). The compound therapeutic efficiency was evaluated based upon clinical improvement and images from the inflamated articulation using 67 Ga citrate before and after 166 Ho-HA injection. Results: The radiochemical purity of the inoculated compound was greater than 98% as measured under sterility conditions. Clinically, an inflammation reduction (2 cm), appetite improvement and general well being was observed. The 166 Ho-HA distribution and localization was monitored using gamma camera images taken at 4 and 24 h. There was no evidence of extra articular leakage. From the 67 Ga citrate imaging, the acute group shows an overall improvement of well being corresponding to a lesser uptake at the inflamated articulation, regarding to the chronic group. The 166 Ho-HA double doses, compared to the single doses, suggest a reduced uptake of 67 Ga citrate at the inflamated tissue, meaning an increased therapeutic effect. Conclusions: 166 Ho-HA is useful as therapeutic agent for the symptomatic treatment of rheumatoid arthritis as shown by imaging and clinical examination

  11. OH and HO2 chemistry in clean marine air during SOAPEX-2

    Directory of Open Access Journals (Sweden)

    R. Sommariva

    2004-01-01

    Full Text Available Model-measurement comparisons of HOx in extremely clean air ([NO] The free-radical chemistry was studied using a zero-dimensional box-model based upon the Master Chemical Mechanism (MCM. Two versions of the model were used, with different levels of chemical complexity, to explore the role of hydrocarbons upon free-radical budgets under very clean conditions. The "detailed" model was constrained to measurements of CO, CH4 and 17 NMHCs, while the "simple" model contained only the CO and CH4 oxidation mechanisms, together with inorganic chemistry. The OH and HO2 (HOx concentrations predicted by the two models agreed to within 5–10%. The model results were compared with the HOx concentrations measured by the FAGE (Fluorescence Assay by Gas Expansion technique during four days of clean Southern Ocean marine boundary layer (MBL air. The models overestimated OH concentrations by about 10% on two days and about 20% on the other two days. HO2 concentrations were measured during two of these days and the models overestimated the measured concentrations by about 40%. Better agreement with measured HO2 was observed by using data from several MBL aerosol measurements to estimate the aerosol surface area and by increasing the HO2 uptake coefficient to unity. This reduced the modelled HO2 overestimate by ~40%, with little effect on OH, because of the poor HO2 to OH conversion at the low ambient NOx concentrations. Local sensitivity analysis and Morris One-At-A-Time analysis were performed on the "simple" model, and showed the importance of reliable measurements of j(O1D and [HCHO] and of the kinetic parameters that determine the efficiency of O(1D to OH and HCHO to HO2 conversion. A 2σ standard deviation of 30–40% for OH and 25–30% for HO2 was estimated for the model calculations using a Monte Carlo technique coupled with Latin Hypercube Sampling (LHS.

  12. A critical scattering study of the helical antiferromagnets Ho and Dy

    International Nuclear Information System (INIS)

    Gaulin, B.D.; Hagen, M.; Child, H.R.

    1988-01-01

    We have measured the frequency integrated magnetic critical scattering of neutrons from paramagnetic Dy and Ho. Analysis of these data show the paramagnetic to helical antiferromagnetic phase transitions are characterized by the critical exponents ν = 0.57 +- 0.05 and γ = 1.05 = +- .07 for Dy and ν = 0.57 +- .04 and γ = 1.14 = +- .10 for Ho. 3 refs., 2 figs., 1 tab

  13. Hodnocení elektrochemických charakteristik tvářených hořčíkových slitin typu Mg-Al-Zn

    OpenAIRE

    Slouková, Karolína

    2016-01-01

    Cílem této diplomové práce je zhodnotit elektrochemické charakteristiky slitin hořčíku. Teoretická část se zabývá popisem vlastností hořčíku i jeho slitin a také jejich korozních charakteristik. V experimentální části jsou interpretovány výsledky měření korozní odolnosti dvou tvářených hořčíkových slitin. Jednalo se o slitiny AZ31 a AZ61, které byly podrobeny měření v Hankových roztocích s přídavkem iontů Ca2+ a Mg2+ (SBF+) a bez jejich přídavku (SBF). Teplota roztoku během měření byla zvolen...

  14. Chronic Ca2+ influx through voltage-dependent Ca2+ channels enhance delayed rectifier K+ currents via activating Src family tyrosine kinase in rat hippocampal neurons.

    Science.gov (United States)

    Yang, Yoon-Sil; Jeon, Sang-Chan; Kim, Dong-Kwan; Eun, Su-Yong; Jung, Sung-Cherl

    2017-03-01

    Excessive influx and the subsequent rapid cytosolic elevation of Ca 2+ in neurons is the major cause to induce hyperexcitability and irreversible cell damage although it is an essential ion for cellular signalings. Therefore, most neurons exhibit several cellular mechanisms to homeostatically regulate cytosolic Ca 2+ level in normal as well as pathological conditions. Delayed rectifier K + channels (I DR channels) play a role to suppress membrane excitability by inducing K + outflow in various conditions, indicating their potential role in preventing pathogenic conditions and cell damage under Ca 2+ -mediated excitotoxic conditions. In the present study, we electrophysiologically evaluated the response of I DR channels to hyperexcitable conditions induced by high Ca 2+ pretreatment (3.6 mM, for 24 hours) in cultured hippocampal neurons. In results, high Ca 2+ -treatment significantly increased the amplitude of I DR without changes of gating kinetics. Nimodipine but not APV blocked Ca 2+ -induced I DR enhancement, confirming that the change of I DR might be targeted by Ca 2+ influx through voltage-dependent Ca 2+ channels (VDCCs) rather than NMDA receptors (NMDARs). The VDCC-mediated I DR enhancement was not affected by either Ca 2+ -induced Ca 2+ release (CICR) or small conductance Ca 2+ -activated K + channels (SK channels). Furthermore, PP2 but not H89 completely abolished I DR enhancement under high Ca 2+ condition, indicating that the activation of Src family tyrosine kinases (SFKs) is required for Ca 2+ -mediated I DR enhancement. Thus, SFKs may be sensitive to excessive Ca 2+ influx through VDCCs and enhance I DR to activate a neuroprotective mechanism against Ca 2+ -mediated hyperexcitability in neurons.

  15. FAGE measurements of tropospheric HO with measurements and model of interferences

    Science.gov (United States)

    Hard, T. M.; Mehrabzadeh, A. A.; Chan, C. Y.; O'Brien, R. J.

    1992-01-01

    Ambient HO measurements by low-pressure laser-excited fluorescence with chemical modulation, and supporting ozone and water-vapor data, are presented for periods in May and August 1987. The observed peak daytime ambient HO concentrations are in the range (2.5 to 8) x 10 exp 6 molecules/cu cm and show small negative offsets due to photochemical interference. Direct measurements of the interference at fixed (O3) give the dependence on ambient (H2O) and on the modulating reagent (isobutane). At ambient (O3) = 30 ppb and 10 torr H2O, with excitation and detection at a total pressure of 4 torr, the net interference is equal to (HO) = -1.3 x 10 exp 6 molecules/cu cm. Production of HO by the reaction of isobutane with O(1D) accounts for the negative interference. Quenching of HO fluorescence by the modulating reagent contributes a smaller positive term to the interference; kinetic measurements of the quenching rate coefficient are reported. The experimental interference results are compared with a detailed kinetic model of HO production, excitation, relaxation, and detection; reasonable agreement is found.

  16. Study on preparation of 166Ho-Chitosan oriented in the treatment of liver cancer

    International Nuclear Information System (INIS)

    Dang Ho Hong Quang; Duong Van Dong; Bui Van Cuong; Nguyen Thanh Binh; Nguyen Thanh Nhan; Nguyen Dinh Lam; Nguyen Thi Thu

    2017-01-01

    This study describes the process for the preparation and quality control of 166 Ho-Chitosan product. The labeling conditions of chitosan with 166 Ho radioisotope were carried out such as the concentration of chitosan, pH, temperature and reaction time to create 166 Ho-Chitosan compositions. Product quality inspection 166 Ho-Chitosan on the criteria as nuclide purity, radiochemical purity, tested for sterility and bacterial endotoxin. The results of survey showed that 166 Ho labeled with chitosan were completed in 1% acetic acid, 3 mCi: 30 mg ratio at pH = 3, marking time at room temperature for 30 minutes. The results of quality test have shown radionuclide purity ≥ 99%, radiochemical purity ≥ 98%, meeting the criteria for the aseptic and bacterial endotoxin according to IV Vietnam pharmacopoeia. From the above mentioned, 166 Ho-Chitosan compositions meet the quality criteria of the radiopharmaceuticals, therefore, it can be used in pre-clinical research and its application in clinical treatment. (author)

  17. Theoretical investigation of electronic and magnetic properties of HoRh layers

    International Nuclear Information System (INIS)

    Masrour, R.; Hlil, E.K.; Hamedoun, M.; Benyoussef, A.; Mounkachi, O.; Bahmad, L.; El Moussaoui, H.

    2013-01-01

    Self-consistent ab initio calculations, based on Density Functional Theory (DFT) approach and using Full potential Linear Augmented Plane Wave (FLAPW) method, are performed to investigate both electronic and magnetic properties of the HoRh layers. Polarized spin and spin–orbit coupling are included in calculations within the framework of the antiferromagnetic state between two sites of Ho. Magnetic moment considered to lie along (001) axes are computed. The data obtained from the ab initio calculations are then used as input for the high temperature series expansions (HTSEs) calculations to compute other magnetic parameters. The exchange integrals between the magnetic atoms in the same sites are given by using mean field theory. The HTSEs of the magnetic susceptibility of HoRh layers spin-S through the Ising model for HoRh layers, are studied to tenth order series in β=1/k B T. The critical exponent γ associated with the magnetic susceptibility is deduced for two models. - Highlights: • Ab initio calculations is using to investigate both electronic and magnetic properties of the HoRh layers. • Obtained data from ab initio calculations are used as input for the HTSEs. • The Néel temperature is obtained for HoRh layers

  18. Study on the preparation of 166Ho-patch for a skin cancer treatment

    International Nuclear Information System (INIS)

    Kim, Y. M.; Kim, K. H.; Han, K. H.; Park, E. W.; Shin, B. C.; Park, K. B.; Lee, J. D.

    1998-01-01

    Radioactive patch containing holmium-166 has been developed for skin cancer treatment, and then applied to animal model and patients with malignant skin cancer. 165Ho-Patch prepared by dissolving polyurethane and 165 Ho(NO 3 ) 3 ·5H 2 O in mixing solvent of DMF and THF and casting on aluminium dish was irradiated in ''HANARO'' reactor ( Φth = 1.25 X 1013 n/cm 2 '·sec, power = 15 MW), which results in preparing 166 Ho-Patch emitting β energy of Max. 1.86 MeV (51 %), 1.78 MeV (48 %), mean 0.67 MeV and low γ energy. The 166 Ho-Patch specially designed was applied to the superficial skin cancers. Their efficacy and safety have been investigated for several months. Radioactive patch was ready to prepare by post-irradiation without special danger by radioactive material. Skin tumor could be successfully treated with 166 Ho-Patch in animal model and patients. In animal model and patients, the world's first noninvasive 166Ho-Patch readily prepared by post-irradiation proved to be safe and effective in treatment for skin cancer

  19. Theoretical investigation of electronic and magnetic properties of HoRh layers

    Energy Technology Data Exchange (ETDEWEB)

    Masrour, R., E-mail: rachidmasrour@hotmail.com [Laboratory of Materials, Processes, Environment and Quality, Cady Ayyed University, National School of Applied Sciences, Sidi Bouzid, Safi (Morocco); LMPHE (URAC 12), Faculty of Science, Mohammed V-Agdal University, Rabat (Morocco); Hlil, E.K. [Institut Néel, CNRS et Université Joseph Fourier, BP 166, F-38042 Grenoble cedex 9 (France); Hamedoun, M. [Institute of Nanomaterials and Nanotechnologies, MAScIR, Rabat (Morocco); Benyoussef, A. [LMPHE (URAC 12), Faculty of Science, Mohammed V-Agdal University, Rabat (Morocco); Institute of Nanomaterials and Nanotechnologies, MAScIR, Rabat (Morocco); Hassan II Academy of Science and Technology, Rabat (Morocco); Mounkachi, O. [Institute of Nanomaterials and Nanotechnologies, MAScIR, Rabat (Morocco); Bahmad, L. [LMPHE (URAC 12), Faculty of Science, Mohammed V-Agdal University, Rabat (Morocco); El Moussaoui, H. [Institute of Nanomaterials and Nanotechnologies, MAScIR, Rabat (Morocco)

    2013-10-15

    Self-consistent ab initio calculations, based on Density Functional Theory (DFT) approach and using Full potential Linear Augmented Plane Wave (FLAPW) method, are performed to investigate both electronic and magnetic properties of the HoRh layers. Polarized spin and spin–orbit coupling are included in calculations within the framework of the antiferromagnetic state between two sites of Ho. Magnetic moment considered to lie along (001) axes are computed. The data obtained from the ab initio calculations are then used as input for the high temperature series expansions (HTSEs) calculations to compute other magnetic parameters. The exchange integrals between the magnetic atoms in the same sites are given by using mean field theory. The HTSEs of the magnetic susceptibility of HoRh layers spin-S through the Ising model for HoRh layers, are studied to tenth order series in β=1/k{sub B}T. The critical exponent γ associated with the magnetic susceptibility is deduced for two models. - Highlights: • Ab initio calculations is using to investigate both electronic and magnetic properties of the HoRh layers. • Obtained data from ab initio calculations are used as input for the HTSEs. • The Néel temperature is obtained for HoRh layers.

  20. Characteristics of gait ataxia in δ2 glutamate receptor mutant mice, ho15J.

    Directory of Open Access Journals (Sweden)

    Eri Takeuchi

    Full Text Available The cerebellum plays a fundamental, but as yet poorly understood, role in the control of locomotion. Recently, mice with gene mutations or knockouts have been used to investigate various aspects of cerebellar function with regard to locomotion. Although many of the mutant mice exhibit severe gait ataxia, kinematic analyses of limb movements have been performed in only a few cases. Here, we investigated locomotion in ho15J mice that have a mutation of the δ2 glutamate receptor. The cerebellum of ho15J mice shows a severe reduction in the number of parallel fiber-Purkinje synapses compared with wild-type mice. Analysis of hindlimb kinematics during treadmill locomotion showed abnormal hindlimb movements characterized by excessive toe elevation during the swing phase, and by severe hyperflexion of the ankles in ho15J mice. The great trochanter heights in ho15J mice were lower than in wild-type mice throughout the step cycle. However, there were no significant differences in various temporal parameters between ho15J and wild-type mice. We suggest that dysfunction of the cerebellar neuronal circuits underlies the observed characteristic kinematic abnormality of hindlimb movements during locomotion of ho15J mice.

  1. GEC-targeted HO-1 expression reduces proteinuria in glomerular immune injury.

    Science.gov (United States)

    Duann, Pu; Lianos, Elias A

    2009-09-01

    Induction of heme oxygenase (HO)-1 is a key defense mechanism against oxidative stress. Compared with tubules, glomeruli are refractory to HO-1 upregulation in response to injury. This can be a disadvantage as it may be associated with insufficient production of cytoprotective heme-degradation metabolites. We, therefore, explored whether 1) targeted HO-1 expression can be achieved in glomeruli without altering their physiological integrity and 2) this expression reduces proteinuria in immune injury induced by an anti-glomerular basement membrane (GBM) antibody (Ab). We employed a 4.125-kb fragment of a mouse nephrin promoter downstream to which a FLAG-tagged hHO-1 cDNA sequence was inserted and subsequently generated transgenic mice from the FVB/N parental strain. There was a 16-fold higher transgene expression in the kidney than nonspecific background (liver) while the transprotein immunolocalized in glomerular epithelial cells (GEC). There was no change in urinary protein excretion, indicating that GEC-targeted HO-1 expression had no effect on glomerular protein permeability. Urinary protein excretion in transgenic mice with anti-GBM Ab injury (days 3 and 6) was significantly lower compared with wild-type controls. There was no significant change in renal expression levels of profibrotic (TGF-beta1) or anti-inflammatory (IL-10) cytokines in transgenic mice with anti-GBM Ab injury. These observations indicate that GEC-targeted HO-1 expression does not alter glomerular physiological integrity and reduces proteinuria in glomerular immune injury.

  2. Embryotoxicity Caused by DON-Induced Oxidative Stress Mediated by Nrf2/HO-1 Pathway

    Directory of Open Access Journals (Sweden)

    Miao Yu

    2017-06-01

    Full Text Available Deoxynivalenol (DON belongs to the type B group of trichothecenes family, which is composed of sesquiterpenoid metabolites produced by Fusarium and other fungi in grain. DON may cause various toxicities, such as cytotoxicity, immunotoxicity, genotoxicity as well as teratogenicity and carcinogenicity. In the present study, we focus on a hypothesis that DON alters the expressions of Nrf2/HO-1 pathway by inducing embryotoxicity in C57BL/6 mouse (5.0, 2.5, 1.0, and 0 mg/kg/day and BeWo cell lines (0 and 50 nM; 3 h, 12 h and 24 h. Our results indicate that DON treatment in mice during pregnancy leads to ROS accumulation in the placenta, which results in embryotoxicity. At the same time Nrf2/HO-1 pathway is up-regulated by ROS to protect placenta cells from oxidative damage. In DON-treated BeWo cells, the level of ROS has time–effect and dose–effect relationships with HO-1 expression. Moderate increase in HO-1 protects the cell from oxidative damage, while excessive increase in HO-1 aggravates the oxidative damage, which is called in some studies the “threshold effect”. Therefore, oxidative stress may be the critical molecular mechanism for DON-induced embryotoxicity. Besides, Nrf2/HO-1 pathway accompanied by the “threshold effect” also plays an important role against DON-induced oxidative damage in this process.

  3. Optical and Physical Investigations of Lanthanum Bismuth Borate glasses doped with Ho2O3

    Science.gov (United States)

    Ramesh, P.; Jagannath, G.; Eraiah, B.; Kokila, M. K.

    2018-02-01

    Holmium doped 10La2O3-15Bi2O3-(75-x) B2O3 (Ho3+: LBB) glasses have been prepared by melt quench technique and the impact of holmium ions concentration on optical and physical properties of present glasses have been examined. Ho3+ dependent density, molar volume, refractive index, rare earth ion concentration, polaron radius, inter ionic distance, field strength and energy band gap are calculated and tabulated. Amorphous nature of the all glasses has been confirmed by XRD patterns. The room temperature (RT) Uv-Vis absorption spectrum doped with 1 mol% of Ho2O3 exhibit eight prominent bands centred at 895, 641, 537, 486, 472, 467, 451 and 416 due to transition between ground state to various excited states. The results show that, the density is increases and molar volume of the glasses is decreases with an increase in Ho2O3 concentration and consequently generate more non-bridging oxygen (NBOs) in the glass matrix. The Urbach energy is increases with holmium concentration which exemplifies the degree of disorder present in the LBB glasses. The considerable increase in field strength observed in present glasses is attributed to occurrence of strong bridge between Ho3+ and B- ions and this strong bridge is possibly due to the displacement between Ho3+ and oxygen atoms which are generated from the conversion BO3-BO4 units.

  4. 36 W Q-switched Ho:YAG laser at 2097 nm pumped by a Tm fiber laser: evaluation of different Ho3+ doping concentrations

    Science.gov (United States)

    Antipov, O. L.; Eranov, I. D.; Kositsyn, R. I.

    2017-01-01

    A laser oscillator based on Ho:YAG crystal pumped by a Tm fiber laser with an acousto-optical Q-switch was optimized for maximum output power and pulse-to-pulse stability. Stable operation at 2097 nm in Q-switched mode is demonstrated, with pulse repetition rates from 10 to 30 kHz, and output power of 36 W (at 55 W of pump power at 1908 nm) in the good quality beam. The influence of Ho ion up-conversion and thermal lensing on the oscillation efficiency is discussed.

  5. Cycle length dependence of the chronotropic effects of adrenaline, acetylcholine, Ca2+ and Mg2+ in the Guinea-pig sinoatrial node

    NARCIS (Netherlands)

    Opthof, T.; de Jonge, B.; Schade, B.; Jongsma, H. J.; Bouman, L. N.

    1984-01-01

    Ca (1.1-5.5 mM) has a positive chronotropic action on isolated right atria of the guinea-pig. The magnitude of the response depends on the cycle length. Magnitude and cycle length dependence of the Ca response are independent of beta-blockade by propranolol. Mg (0.6-6.0 mM) has a negative

  6. Contacting graphene in a 200 mm wafer silicon technology environment

    Science.gov (United States)

    Lisker, Marco; Lukosius, Mindaugas; Kitzmann, Julia; Fraschke, Mirko; Wolansky, Dirk; Schulze, Sebastian; Lupina, Grzegorz; Mai, Andreas

    2018-06-01

    Two different approaches for contacting graphene in a 200 mm wafer silicon technology environment were tested. The key is the opportunity to create a thin SiN passivation layer on top of the graphene protecting it from the damage by plasma processes. The first approach uses pure Ni contacts with a thickness of 200 nm. For the second attempt, Ni is used as the contact metal which substitutes the Ti compared to a standard contact hole filling process. Accordingly, the contact hole filling of this "stacked via" approach is Ni/TiN/W. We demonstrate that the second "stacked Via" is beneficial and shows contact resistances of a wafer scale process with values below 200 Ohm μm.

  7. 40 mm bore Nb-Ti model dipole magnet

    International Nuclear Information System (INIS)

    Taylor, C.; Gilbert, W.; Hassenzahl, W.; Meuser, R.; Peters, C.; Rechen, J.; Scanlan, R.

    1984-01-01

    Preliminary R and D has been started on magnets for a next-generation high-energy-physics accelerator, the 20 TeV Superconducting Supercollider (SSC). One design now being developed at LBL is described in this paper. The design is based on two layers of flattened Nb-Ti cable, a 40 mm ID winding with flared ends, and an operating field of 6.5 T. Experimental results are presented on several one-meter-long models tested at both He I and He II temperature. Measurement of field, residual magnetization, quench propagation velocity, and winding prestress are presented. (A 2-in-1 magnet based on this coil design is being jointly developed by LBL and Brookhaven National Laboratory, and 15 ft. long models are being constructed at BNL)

  8. Diagnostic capability of 100-mm roll film digitizer system

    International Nuclear Information System (INIS)

    Kono, M.; Yamasaki, K.; Ikeda, M.

    1988-01-01

    The authors recently developed a roll film digitizer system. The sampling pitch is 100 μm. a scientific image study (Barger phantom, Hawlet chart, and modulation transfer function), receiver operating characteristic (ROC) study, and clinical evaluation were performed. For the ROC study, a chest phantom with simulated nodule and hairline was used. Differences in accuracy between readings of cathode ray tube (CRT) images and roll film images were not statistically significant for hairline and coin lesions, P<.05). As a clinical evaluation, eight radiologists evaluated predetermined radiologic findings on a five-point rating scale compared with original roll film images. Scores for CRT images were equal to those for the original roll film images. In conclusion, CRT images (1,000 x 1,000) were found to be sufficient for diagnostic accuracy of chest images compared with roll film images (100 x 100 mm)

  9. Supersonic Love waves in strong piezoelectrics of symmetry mm2

    International Nuclear Information System (INIS)

    Darinskii, A. N.; Weihnacht, M.

    2001-01-01

    A study has been made of the Love wave propagation on piezoelectric substrates of symmetry mm2. It has been shown that under certain conditions the velocity of the Love wave exceeds that of shear horizontal (SH) bulk waves in the substrate. This occurs when the slowness curve of SH bulk waves in the substrate either has a concavity or is convex with nearly zero curvature. For such 'supersonic' Love waves to appear, it is also required that the substrate as well as the layer be specially oriented and that their material constants fulfill a number of inequalities. Numerical computations have been carried out for a number of structures. The results of numerical computations have been compared with approximate analytical estimations. [copyright] 2001 American Institute of Physics

  10. Magnetic design of a 14 mm period prototype superconducting undulator

    Energy Technology Data Exchange (ETDEWEB)

    Gehlot, Mona, E-mail: mona_gehlot@yahoo.com [Insertion Device Development Laboratory, School of Physics, Devi Ahilya University, Indore 452001, MP (India); Mishra, G. [Insertion Device Development Laboratory, School of Physics, Devi Ahilya University, Indore 452001, MP (India); Institute of Engineering, UNAM (Mexico); Soleil, Paris (France); Trillaud, Frederic [Institute of Engineering, UNAM (Mexico); Sharma, Geetanjali [Soleil, Paris (France)

    2017-02-21

    In this paper we report the design of a 14 mm period prototype superconducting undulator that is under fabrication at Insertion Device Development Laboratory (IDDL) at Devi Ahilya Vishwavidyalaya, Indore, India. The field computations are made in RADIA and results are presented in an analytical form for computation of the on axis field and the field on the surface of the coil. On the basis of the findings, a best fit is presented for the model to calculate the field dependence on the gap and the current density. The fit is compared with Moser-Rossmanith formula proposed earlier to predict the magnetic flux density of a superconducting undulator. The field mapping is used to calculate the field integrals and its dependence on gap and current densities as well.

  11. Uniformity across 200 mm silicon wafers printed by nanoimprint lithography

    International Nuclear Information System (INIS)

    Gourgon, C; Perret, C; Tallal, J; Lazzarino, F; Landis, S; Joubert, O; Pelzer, R

    2005-01-01

    Uniformity of the printing process is one of the key parameters of nanoimprint lithography. This technique has to be extended to large size wafers to be useful for several industrial applications, and the uniformity of micro and nanostructures has to be guaranteed on large surfaces. This paper presents results of printing on 200 mm diameter wafers. The residual thickness uniformity after printing is demonstrated at the wafer scale in large patterns (100 μm), in smaller lines of 250 nm and in sub-100 nm features. We show that a mould deformation occurs during the printing process, and that this deformation is needed to guarantee printing uniformity. However, the mould deformation is also responsible for the potential degradation of the patterns

  12. Coil and iron design for SSC 50 mm magnet

    International Nuclear Information System (INIS)

    Gupta, R.C.; Kahn, S.A.; Morgan, G.H.

    1990-01-01

    In this paper we present the design of the two dimensional coil and iron cross section, referred to as DSX201/W6733, for the 50 mm aperture dipole magnet being built at the Brookhaven National Laboratory for the Superconducting Super Collider (SSC). The computed values of the allowed field harmonics as a function of current, the quench performance predictions, the stored energy calculations, the effect of random errors on the coil placement and the Lorentz forces on the coil will be presented. The yoke has been optimized to reduce iron saturation effects on the field harmonics. We shall present the summary of this design which will include the expected overall performance of this cross section. 4 refs., 8 figs., 12 tabs

  13. Accessing the nuclear symmetry energy in Ca+Ca collisions

    Directory of Open Access Journals (Sweden)

    Chbihi A.

    2012-07-01

    Full Text Available The status of the analysis of the INDRA-VAMOS experiement performed at GANIL, using the reactions 40,48Ca+40,48Ca reactions at 35AMeV, are presented. Isotopic distributions of fragments produced in multifragmentation events provide information on the importance of the surface term contribution in the symmetry energy by comparison to AMD predictions.

  14. Effect of Ca2+ overload on phosphoinositide (PI) metabolism in cardiac muscle

    International Nuclear Information System (INIS)

    Otani, H.; Otani, H.; Engelman, R.M.; Das, D.K.

    1986-01-01

    The investigated the relationship between Ca 2+ load and PI metabolism in isolated rat papillary muscle labeled with [ 3 H]inositol. Increase in [Ca 2+ ]/sub o/ from 0-3.6 mM reduced the incorporation of [ 3 H] inositol into PI moderately and increased the resting tension slightly. The incorporation of the label into PI was unchanged by 10 μm A-23187 at 1.8 mM [Ca 2+ ]/sub o/ that increased the contractility by 70% without a significant change in the resting tension. However, either 10.8 mM [Ca 2+ ]/sub o/ or 0.3 mM ouabain at 1.8 mM [Ca 2+ ]/sub o/ markedly decreased the PI labeling with corresponding increase in the resting tension while inclusion of excess EGTA greatly enhanced the radioactivity in PI. Determination of the PI breakdown and the inositol phosphates production by pulse-chase experiments revealed that the reduced PI turnover in the Ca 2+ -overload muscle was due to both inhibition of the synthesis and stimulation of the breakdown of this lipid that accounted for 30% decrease in the labeled PI from the muscle during 45 min without significant loss of the net PI pool size, suggesting the presence of a relatively smaller compartment of PI pool undergoing a rapid breakdown during Ca 2+ overload. The authors propose that alteration of Ca 2+ homeostasis may modulate the production of putative second messengers, inositol trisphosphate and diacylglycerol, which feed back to regulate [Ca 2+ ]/sub i/ in cardiac muscle

  15. High-frequency spectral ultrasound imaging (SUSI) visualizes early post-traumatic heterotopic ossification (HO) in a mouse model.

    Science.gov (United States)

    Ranganathan, Kavitha; Hong, Xiaowei; Cholok, David; Habbouche, Joe; Priest, Caitlin; Breuler, Christopher; Chung, Michael; Li, John; Kaura, Arminder; Hsieh, Hsiao Hsin Sung; Butts, Jonathan; Ucer, Serra; Schwartz, Ean; Buchman, Steven R; Stegemann, Jan P; Deng, Cheri X; Levi, Benjamin

    2018-04-01

    Early treatment of heterotopic ossification (HO) is currently limited by delayed diagnosis due to limited visualization at early time points. In this study, we validate the use of spectral ultrasound imaging (SUSI) in an animal model to detect HO as early as one week after burn tenotomy. Concurrent SUSI, micro CT, and histology at 1, 2, 4, and 9weeks post-injury were used to follow the progression of HO after an Achilles tenotomy and 30% total body surface area burn (n=3-5 limbs per time point). To compare the use of SUSI in different types of injury models, mice (n=5 per group) underwent either burn/tenotomy or skin incision injury and were imaged using a 55MHz probe on VisualSonics VEVO 770 system at one week post injury to evaluate the ability of SUSI to distinguish between edema and HO. Average acoustic concentration (AAC) and average scatterer diameter (ASD) were calculated for each ultrasound image frame. Micro CT was used to calculate the total volume of HO. Histology was used to confirm bone formation. Using SUSI, HO was visualized as early as 1week after injury. HO was visualized earliest by 4weeks after injury by micro CT. The average acoustic concentration of HO was 33% more than that of the control limb (n=5). Spectroscopic foci of HO present at 1week that persisted throughout all time points correlated with the HO present at 9weeks on micro CT imaging. SUSI visualizes HO as early as one week after injury in an animal model. SUSI represents a new imaging modality with promise for early diagnosis of HO. Copyright © 2018 Elsevier Inc. All rights reserved.

  16. HoYbBIG epitaxial thick films used for Faraday rotator in the 1.55μm band

    International Nuclear Information System (INIS)

    Zhong, Z.W.; Xu, X.W.; Chong, T.C.; Yuan, S.N.; Li, M.H.; Zhang, G.Y.; Freeman, B.

    2005-01-01

    Ho 3-x-y Yb y Bi x Fe 5 O 12 (HoYbBIG) garnet thick films with Bi content of x=0.9-1.5 were prepared by the liquid phase epitaxy (LPE) method. Optical properties and magneto-optical properties were characterized. The LPE-grown HoYbBIG thick films exhibited large Faraday rotation coefficients up to 1540 o /cm at 1.55μm, and good wavelength and temperature stability

  17. Návrh posuvu fokusačního objektivu uvnitř interakční komory LIBS aparatury

    OpenAIRE

    Olejník, Ivan

    2008-01-01

    Diplomová práca popisuje návrh posuvu fokusačného objektívu vo vnútri interakčnej komory LIBS. Obsahuje popis základných vlastností a funkcií LIBS spektroskopie. Opisuje prehžad použitežných komponentov, hodnotí ich vlastnosti a vhodnosť použitia v konštrukcii posuvu do vákua. Ďalej uvádza výsledné konštrukčné riešenie lineárneho posuvu do vákua a hodnotí jeho výhody pre metódu LIBS. This diploma thesis describes the design of a translation stage for focusing objective inside the LIBS inte...

  18. Animal experiments and clinical trials of 166Ho-Chitosan for various cancers

    International Nuclear Information System (INIS)

    Lim, S.M.; Choi, C.W.; Park, S.Y.; Lee, S.H.; Lee, B.H.; Park, K.B.

    1998-01-01

    166 Ho-Chitosan is a complex of 166 Ho and N-glucosamine with 400 to 500 kD MW, which chelates metal ions and degrades slowly in vivo. In mice, 166 H-Chitosan administered intraperitoneally was uniformly bound to the peritoneal wall (94%), and the surface dose calculated by Monte Carlo simulation (EGS 4 code) was 81 Gy/uCi/cm 2 . 166 Ho-Chitosan was administered intraperitoneally as an adjunct in the treatment of ovarian cancer with diffuse spread of malignant cells in the peritoneal surfaces including the diaphragm. 97-99% of 166 Ho-Chitosan was localized within the peritoneal cavity, and more than 90% of 166 Ho-Chitosan was attached to the peritoneal wall. Partial response were observed in 4 among 5 patients with ovarian cancer without severe toxicity. Intracavitary radiation therapy with 166 Ho-Chitosan in the cystic brain tumor, 5 or 8 cysts were shrunken in size with thinning of the wall, 2 out of 8 showed growth retardation. For large or multiple primary liver cancers, which were inoperable and resistent to chemotherapy. 166 Ho-Chitosan was used for intraarterial injection, because this solution became gel with neutral pH. In the primary liver cancer, radioactivity was distributed in the territory of selected hepatic arterial branch, and partial responses were observed in 2 cases. For the large solitary liver tumor, which was not operable due to its location, direct intratumoral injection of the radioisotope had a limited response. 18 FDG PET was a useful tool to follow up those radionuclide therapy, and guide to plan the next therapy. In one case of the large single metastatic stomach cancer in the liver, 18 FDG PET was done two weeks after intratumoral injection of 166 Ho-Chitosan, which showed cold defects matched with distribution of 166 Ho-Chitosan, and second injection was guided by PET image. Various methods of the administration of 166 Ho-Chitosan could be used for the treatment of the cancers. (author)

  19. Selective degradation of lignin and elimination of HO radicals in pulps by O3 and UV laser flash irradiation

    Institute of Scientific and Technical Information of China (English)

    林鹿; 周贤涛; 邱玉桂

    2002-01-01

    HO radical is an aggressive reagent to abstract hydrogen from diverse substitutes and lead them to degradation, however, in reaction of active oxygen species with lignins, complex phenolic polymers, in dispersed lignocellulose such as pulp for environment-benign delignification, HO radicals should be eliminated as more as possible to prevent cellulose from unfavorably concomitant degradation. A reaction system of O3 is constructed under UV laser flash irradiation, and HO radicals are controlled efficiently by it. A new mechanism is proposed, for the first time, that O radicals generated from reaction of O3 with UV laser flash irradiation might be the contributor to scavenge HO radicals.

  20. Production, Quality Control and Biological Evaluation of 166Ho-PDTMP as a Possible Bone Palliation Agent

    Directory of Open Access Journals (Sweden)

    Samaneh Zolghadri

    2013-05-01

    Full Text Available Objective(s:In this study, 166Ho-1,2-propylene di-amino tetra(methy1enephosphonicAcid (166Ho-PDTMP complex  was prepared as a bone palliation agent. Materials and Methods:The complex was successfully prepared using an in-house synthesized EDTMP ligand and 166HoCl3. Ho-166 chloride was obtained by thermal neutron irradiation (1 × 1013 n.cm-2.s-1 of natural Ho(NO33 samples  followed by radiolabeling and stability studies. Biodistribution in wild type rats was also peformed. Results: The complex was prepared with thespecific activity of 278 GBq/mg and high radiochemical purity (>99%, checked by ITLC. 166Ho-PDTMP complex was stabilized in the final preparation and in the presence of human serum (>90% up to 72 hr. The biodistribution of 166Ho-PDTMP in wild-type rats demonstrated significant bone uptake was up to 48 hr compared to 166HoCl3. Conclusion: The produced 166Ho-PDTMP properties suggest a possible new bone palliative therapeutic to overcome the metastatic bone pains.  

  1. Optical spectroscopy and luminescence properties of Ho3+ doped zinc fluorophosphate (ZFP) glasses for green luminescent device applications

    Science.gov (United States)

    Reddy Prasad, V.; Damodaraiah, S.; Ratnakaram, Y. C.

    2018-04-01

    Ho3+ doped zinc fluorophosphate (ZFP) glasses with molar chemical compositions, (60-x) NH4H2PO4+20ZnO+10BaF2+10NaF+xHo2O3 (where x = 0.1, 0.3, 0.5, 1.0 and 1.5 mol%) were prepared by melt quenching technique. These glasses were characterized through physical, structural, optical, excitation, luminescence and decay curve analysis. From the absorption spectra, spectral intensities (fexp and fcal), Judd-Ofelt intensity parameters (Ω2, Ω4 and Ω6), radiative transition probabilities (AT), radiative lifetimes (τR) and branching ratios (βR) were evaluated for all Ho3+ doped ZFP glass matrices. From the photoluminescence spectra, peak stimulated emission cross-sections (σP) were calculated for all Ho3+ doped ZFP glasses. The Ho3+ doped ZFP glasses show strong green emission at 545 nm and red emission at 656 nm under excitation, 450 nm. The measured lifetimes (τmeas) of (5S2)5F4 level of Ho3+ doped ZFP glasses were obtained from decay profiles. The CIE color coordinates of Ho3+ doped ZFP glasses were calculated from emission spectra and 1.0 mol% of Ho3+ doped ZFP glass matrix gives green emission. Hence, these results confirm that the Ho3+ doped ZFP glasses could be considered as a promising candidate for visible green laser applications.

  2. Heterogeneous reaction of HO2 with airborne TiO2 particles and its implication for climate change mitigation strategies

    Science.gov (United States)

    Moon, Daniel R.; Taverna, Giorgio S.; Anduix-Canto, Clara; Ingham, Trevor; Chipperfield, Martyn P.; Seakins, Paul W.; Baeza-Romero, Maria-Teresa; Heard, Dwayne E.

    2018-01-01

    One geoengineering mitigation strategy for global temperature rises resulting from the increased concentrations of greenhouse gases is to inject particles into the stratosphere to scatter solar radiation back to space, with TiO2 particles emerging as a possible candidate. Uptake coefficients of HO2, γ(HO2), onto sub-micrometre TiO2 particles were measured at room temperature and different relative humidities (RHs) using an atmospheric pressure aerosol flow tube coupled to a sensitive HO2 detector. Values of γ(HO2) increased from 0.021 ± 0.001 to 0.036 ± 0.007 as the RH was increased from 11 to 66 %, and the increase in γ(HO2) correlated with the number of monolayers of water surrounding the TiO2 particles. The impact of the uptake of HO2 onto TiO2 particles on stratospheric concentrations of HO2 and O3 was simulated using the TOMCAT three-dimensional chemical transport model. The model showed that, when injecting the amount of TiO2 required to achieve the same cooling effect as the Mt Pinatubo eruption, heterogeneous reactions between HO2 and TiO2 would have a negligible effect on stratospheric concentrations of HO2 and O3.

  3. Heterogeneous reaction of HO2 with airborne TiO2 particles and its implication for climate change mitigation strategies

    Directory of Open Access Journals (Sweden)

    D. R. Moon

    2018-01-01

    Full Text Available One geoengineering mitigation strategy for global temperature rises resulting from the increased concentrations of greenhouse gases is to inject particles into the stratosphere to scatter solar radiation back to space, with TiO2 particles emerging as a possible candidate. Uptake coefficients of HO2, γ(HO2, onto sub-micrometre TiO2 particles were measured at room temperature and different relative humidities (RHs using an atmospheric pressure aerosol flow tube coupled to a sensitive HO2 detector. Values of γ(HO2 increased from 0.021 ± 0.001 to 0.036 ± 0.007 as the RH was increased from 11 to 66 %, and the increase in γ(HO2 correlated with the number of monolayers of water surrounding the TiO2 particles. The impact of the uptake of HO2 onto TiO2 particles on stratospheric concentrations of HO2 and O3 was simulated using the TOMCAT three-dimensional chemical transport model. The model showed that, when injecting the amount of TiO2 required to achieve the same cooling effect as the Mt Pinatubo eruption, heterogeneous reactions between HO2 and TiO2 would have a negligible effect on stratospheric concentrations of HO2 and O3.

  4. Structural relative stabilities and pressure-induced phase transitions for lanthanide trihydrides REH{sub 3} (RE=Sm, Gd, Tb, Dy, Ho, Er, Tm, and Lu)

    Energy Technology Data Exchange (ETDEWEB)

    Kong Bo, E-mail: kong79@yeah.net [National Key Laboratory for Shock Wave and Detonation Physics Research, Institute of Fluid Physics, Chinese Academy of Engineering Physics, Mianyang 621900 (China); College of Physical Science and Technology, Sichuan University, Chengdu 610064 (China); Zhang Lin, E-mail: zhanglinbox@263.net [National Key Laboratory for Shock Wave and Detonation Physics Research, Institute of Fluid Physics, Chinese Academy of Engineering Physics, Mianyang 621900 (China); Chen Xiangrong [College of Physical Science and Technology, Sichuan University, Chengdu 610064 (China); Zeng Tixian [College of Physics and Electronic Information, China West Normal University, Nanchong 637002 (China); Cai Lingcang [National Key Laboratory for Shock Wave and Detonation Physics Research, Institute of Fluid Physics, Chinese Academy of Engineering Physics, Mianyang 621900 (China)

    2012-06-15

    The structures, structural relative stabilities, pressure-induced phase transitions, and equations of state for lanthanide trihydrides REH{sub 3} (RE=Sm, Gd, Tb, Dy, Ho, Er, Tm, and Lu) are systematically studied using ab initio calculations under a core state model (CSM). The obtained ground-state parameters, such as lattice constants and bulk modulus, agree well with the available data. Among the P6{sub 3}/mm, P3-bar c1, and P6{sub 3}cm structures, the P6{sub 3}cm structure is found to be the most stable structure for lanthanide trihydride via the comparison of the calculated total energies. With the help of Birch-Murnaghan equation of state, the structural transitions from hexagonal to cubic for REH{sub 3} (RE=Sm, Gd, Ho, Er, and Lu) under pressure are affirmed; especially, the similar behavior of REH{sub 3} (RE= Tb, Dy, and Tm) is reasonably predicted for the first time by this means. For the transitions, the repulsive interactions of H-H atoms may play an important role in terms of the analysis of the structures in the vicinity of the theoretical phase transition.

  5. Updating the model TREMOD - Mobile Machinery (TREMOD-MM); Aktualisierung des Modells TREMOD - Mobile Machinery (TREMOD-MM)

    Energy Technology Data Exchange (ETDEWEB)

    Helms, Hinrich; Lambrecht, Udo; Knoerr, Wolfram [ifeu - Institut fuer Energie- und Umweltforschung Heidelberg gGmbH, Heidelberg (Germany)

    2010-05-15

    In the context of the project ''Development of a model for the computation of the air pollutant emissions and the fuel consumption of combustion engines in mobile devices and machines'', the Institute for Energy and Environmental Research GmbH (Heidelberg, Federal Republic of Germany) has created the model TREMOD-MM (TREMOD Mobile Machinery). Thus a detailed computation of the emissions from mobile devices and machines in the agriculture, construction industry, forestry and gardening as well as the sport shipping and passenger shipping can be accomplished. Strongly differentiated data are considered to the age structure, engine performance, use and emission behaviour. Thus it is possible to compute the emissions for different scenarios in high degree of detail.

  6. Experimental characteristics of a high-gain free-electron laser amplifier operating at 8-mm and 2-mm wavelengths

    International Nuclear Information System (INIS)

    Throop, A.L.; Orzechowski, T.J.; Anderson, B.R.

    1987-01-01

    The Electron Laser Facility (ELF) at the Lawrence Livermore National Laboratory (LLNL) uses a high-current induction linac (3.5 MeV, 1000 A), in conjunction with a pulsed electromagnetic wiggler (4.0 M, 4000 G), to operate a free electron laser (FEL) that produces intense radiation in the microwave regime (2 to 8 mm). ELF is a high-gain, single-pass amplifier, using a commercial microwave source as an oscillator input (200 W-50 kW). Previous experiments at 35 GHz produced exponential gains of 40 dB/m, peak powers exceeding 1 GW, and beam-to-rf conversion efficiencies of 34%. Recent experiments at 140 GHz have demonstrated exponential gains of 22 dB/m, peak powers exceeding 50 MW, and total gains of 65 dB. In this paper, we describe the experimental results at these two frequencies and compare then with the predictions of simulation codes

  7. Monitoring of Volcanic Activity by Sub-mm Geodetic Analyses

    Science.gov (United States)

    Miura, S.; Mare, Y.; Ichiki, M.; Demachi, T.; Tachibana, K.; Nishimura, T.

    2017-12-01

    Volcanic earthquakes have been occurring beneath Zao volcano in northern Honshu, Japan since 2013, following the increase of deep low frequency earthquakes from 2012. On account of a burst of seismicity initiated in April 2015, the JMA announced a warning of eruption, however, the seismicity gradually decreased for the next two months and the warning was canceled in June. In the same time period, minor expansive deformation was observed by GNSS. Small earthquakes are still occurring, and low-freq. earthquakes (LPE) occur sometimes accompanied by static tilt changes. In this study, we try to extract the sub-mm displacements from the LPE waveforms observed by broadband seismometers (BBS) and utilize them for geodetic inversion to monitor volcanic activities. Thun et al. (2015, 2016) devised an efficient method using a running median filter (RMF) to remove LP noises, which contaminate displacement waveforms. They demonstrated the reproducibility of the waveforms corresponding to the experimentally given sub-mm displacements in the laboratory. They also apply the method to the field LPE data obtained from several volcanoes to show static displacements. The procedure is outlined as follows: (1) Unfiltered removal of the instrument response, (2) LP noise estimate by LPF with a corner frequency of 5/M, where M (seconds) is the time window of the RMF and should be at least three times the length of the rise time. (3) Subtract the noise estimated from step (2). (4) Integrate to obtain displacement waveforms. We apply the method to the BBS waveform at a distance of about 1.5 km ESE from the summit crater of Zao Volcano associated with a LPE on April 1, 2017. Assuming the time window M as 300 seconds, we successfully obtained the displacement history: taking the rise time of about 2 minutes, the site was gradually uplifted with the amount of about 50-60 µm and then subsided with HF displacements in the next 2 minutes resulting about 20-30 µm static upheaval. Comparing the

  8. Density-functional study of the structures and properties of holmium-doped silicon clusters HoSi n (n = 3-9) and their anions.

    Science.gov (United States)

    Hou, Liyuan; Yang, Jucai; Liu, Yuming

    2017-04-01

    The structures and properties of Ho-doped Si clusters, including their adiabatic electron affinities (AEAs), simulated photoelectron spectra (PESs), stabilities, magnetic moments, and charge-transfer characteristics, were systematically investigated using four density-functional methods. The results show that the double-hybrid functional (which includes an MP2 correlation component) can accurately predict the ground-state structure and properties of Ho-doped Si clusters. The ground-state structures of HoSi n (n = 3-9) are sextuplet electronic states. The structures of these Ho-doped Si clusters (aside from HoSi 7 ) are substitutional. The ground-state structures of HoSi n - are quintuplet electronic states. Their predicted AEAs are in excellent agreement with the experimental ones. The mean absolute error in the theoretical AEAs of HoSi n (n = 4-9) is only 0.04 eV. The simulated PESs for HoSi n - (n = 5-9) are in good agreement with the experimental PESs. Based on its simulated PES and theoretical AEA, we reassigned the experimental PES of HoSi 4 - and obtained an experimental AEA of 2.2 ± 0.1 eV. The dissociation energies of Ho from HoSi n and HoSi n - (n = 3-9) were evaluated to test the relative stabilities of the clusters. HOMO-LUMO gap analysis indicated that doping the Si clusters with the rare-earth metal atom significantly increases their photochemical reactivity. Natural population analysis showed that the magnetic moments of HoSi n (n = 3-9) and their anions derive mainly from the Ho atom. It was also found that the magnetic moments of Ho in the HoSi n clusters are larger than the magnetic moment of an isolated Ho atom.

  9. Preliminary results in double cusp tandem mirror MM-4U

    International Nuclear Information System (INIS)

    Ming Linzhou; Tian Zhongyu; Feng Xiaozhen

    1990-10-01

    MM-4U device and preliminary experimental results are presented. Main results are as follows: The plasma has been produced by means of the injection of strong electron current; the axial profile of the plasma potential and the plasma electron density have been obtained respectively, they had a simular form; the plasma potential in the centre of the east cusp, the west cusp and the simple mirror; V e = -180V, V w = -164V, V m -1.8V; the electron density: n e = 1.7 x 10 11 cm -3 , n w = 4.7 x 10 10 cm -3 , n m = 7.5 x 10 7 cm -3 ; the electron temperature: T e = (19.9 ± 1.6) eV, T w = (20.7 ± 1.7) eV; the plasma pressure at 8 cm on the right of the west cusp centre is about 6.76 Pa, β ≅ 1.7 x 10 -3 . The plasma instability has been observed in the simple mirror, its vibration frequency was 7∼9.2 kHz. The results are discussed. The next new task of the physical experiment are proposed

  10. Performance of modern tide gauges: towards mm-level accuracy

    Directory of Open Access Journals (Sweden)

    Belén Martín Míguez

    2012-09-01

    Full Text Available Considerable efforts are being made worldwide to upgrade tide gauge networks using new technologies. Because of the unique location of the Kerguelen Islands, the measurement of sea level there has received particular attention, with up to four systems equipped with modern sensors functioning simultaneously (two pressure tide gauges, a radar tide gauge, and a GPS-equipped buoy. We analysed and compared the sea level data obtained with these systems from 2003 to 2010, together with a time series of tide pole observations. This is the first time that a multi-comparison study with tide gauges has been undertaken over such a long time span and that the stability of modern radar tide gauges has been examined. The multi-comparison enabled us to evaluate the performance of the tide gauges in several frequency ranges, identify errors and estimate their magnitude. The drift of the pressure sensors (up to 8.0 mm/yr was found to be one of the most relevant sources of systematic error. Other sources of difference such as clock drift, scale error and different locations of the instruments were also detected. After correcting the time series of sea level for these errors we estimated an upper bound for the radar instrumental error in field condition at ~0.3 cm.

  11. Hybrid Welding of 45 mm High Strength Steel Sections

    Science.gov (United States)

    Bunaziv, Ivan; Frostevarg, Jan; Akselsen, Odd M.; Kaplan, Alexander F.

    Thick section welding has significant importance for oil and gas industry in low temperature regions. Arc welding is usually employed providing suitable quality joints with acceptable toughness at low temperatures with very limited productivity compared to modern high power laser systems. Laser-arc hybrid welding (LAHW) can enhance the productivity by several times due to higher penetration depth from laser beam and combined advantages of both heat sources. LAHW was applied to join 45 mm high strength steel with double-sided technique and application of metal cored wire. The process was captured by high speed camera, allowing process observation in order to identify the relation of the process stability on weld imperfections and efficiency. Among the results, it was found that both arc power and presence of a gap increased penetration depth, and that higher welding speeds cause unstable processing and limits penetration depth. Over a wide range of heat inputs, the welds where found to consist of large amounts of fine-grained acicular ferrite in the upper 60-75% part of welds. At the root filler wire mixing was less and cooling faster, and thus found to have bainitic transformation. Toughness of deposited welds provided acceptable toughness at -50 °C with some scattering.

  12. Theory of K-MM radiative-Auger transitions

    International Nuclear Information System (INIS)

    Baptista, G.B.

    1975-01-01

    Presently available calculations of transition probabilities for radiative-Auger and double-Auger processes are based on shake-off theory. In this theory, such processes are thought of as being due to electron core rearrangement associated with de-excitation of an inner shell vacancy. It is suggested that radiative-Auger processes result from the interaction of two electrons with one another and the radiation field in the presence of an inner shell vacancy, while double-Auger processes result from the interaction of an electron with two electrons in the presence of a similar vacancy. Expressions for the transition probabilities of these processes are derived in second order time dependent perturbation theory. The interaction is taken as the sum of the Coulomb interaction and electron-field interaction of the electrons involved. This approach allows calculation of the detailed photon or electron energy distribution resulting from such processes, as well as the relative and absolute transition rates involved. As a specific example of this approach the transition probability for the K-MM radiative-Auger effect in argon is calculated and compared with available experimental data. Scaled Thomas-Fermi wavefunctions are used to calculate the total transition probability which is found to be 2.68 x 10 -4 eV/h-bar In addition, the spectral distribution of emitted photons is obtained, and agreement both in magnitude and with the general features of the experimental data is excellent

  13. Cordycepin alleviates lipopolysaccharide-induced acute lung injury via Nrf2/HO-1 pathway.

    Science.gov (United States)

    Qing, Rui; Huang, Zezhi; Tang, Yufei; Xiang, Qingke; Yang, Fan

    2018-04-24

    The present study is to investigate the protective effect of cordycepin on inflammatory reactions in rats with acute lung injury (ALI) induced by lipopolysaccharide (LPS), as well as the underlying mechanism. Wistar rat model of ALI was induced by intravenous injection of LPS (30 mg/kg body weight). One hour later, intravenous injection of cordycepin (1, 10 or 30 mg/kg body weight) was administered. The wet-to-dry weight ratio of lung tissues and myeloperoxidase activity in the lung tissues were measured. The contents of nitrite and nitrate were measured by reduction method, while chemiluminescence was used to determine the content of superoxide. Quantitative real-time polymerase chain reaction and Western blotting were used to determine the expression of mRNA and protein, respectively. Colorimetry was performed to determine the enzymatic activity of heme oxygenase-1 (HO-1). Nuclear translocation of Nrf2 was identified by Western blotting. The plasma contents of cytokines were measured by enzyme-linked immunosorbent assay. Cordycepin enhanced the expression and enzymatic activity of HO-1 in ALI rats, and activated Nrf2 by inducing the translocation of Nrf2 from cytoplasm to nucleus. In addition, cordycepin regulated the secretion of TNF-α, IL-6 and IL-10 via HO-1, and suppressed inflammation in lung tissues of ALI rats by inducing the expression of HO-1. HO-1 played important roles in the down-regulation of superoxide levels in lung tissues by cordycepin, and HO-1 expression induced by cordycepin affected nitrite and nitrate concentrations in plasma and iNOS protein expression in lung tissues. Cordycepin showed protective effect on injuries in lung tissues. The present study demonstrates that cordycepin alleviates inflammation induced by LPS via the activation of Nrf2 and up-regulation of HO-1 expression. Copyright © 2018. Published by Elsevier B.V.

  14. Growth, spectroscopy and laser operation of Ho:KY(WO{sub 4}){sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Jambunathan, V. [Física i Cristallografia de Materials i Nanomaterials (FiCMA-FiCNA), Universitat Rovira i Virgili (URV), Campus Sescelades, c/ Marcellí Domingo, s/n. E-43007 Tarragona (Spain); HiLASE Centre, Institute of Physics ASCR, Za Radnicí 828, 25241 Dolní Břežany (Czech Republic); Mateos, X., E-mail: xavier.mateos@urv.cat [Física i Cristallografia de Materials i Nanomaterials (FiCMA-FiCNA), Universitat Rovira i Virgili (URV), Campus Sescelades, c/ Marcellí Domingo, s/n. E-43007 Tarragona (Spain); Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy, 2A Max-Born-Str., D-12489 Berlin (Germany); Loiko, P.A. [Física i Cristallografia de Materials i Nanomaterials (FiCMA-FiCNA), Universitat Rovira i Virgili (URV), Campus Sescelades, c/ Marcellí Domingo, s/n. E-43007 Tarragona (Spain); Center for Optical Materials and Technologies, Belarusian National Technical University, 65/17 Nezavisimosti Ave., 220013 Minsk (Belarus); Serres, J.M. [Física i Cristallografia de Materials i Nanomaterials (FiCMA-FiCNA), Universitat Rovira i Virgili (URV), Campus Sescelades, c/ Marcellí Domingo, s/n. E-43007 Tarragona (Spain); Griebner, U.; Petrov, V. [Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy, 2A Max-Born-Str., D-12489 Berlin (Germany); Yumashev, K.V. [Center for Optical Materials and Technologies, Belarusian National Technical University, 65/17 Nezavisimosti Ave., 220013 Minsk (Belarus); and others

    2016-11-15

    Monoclinic Ho:KY(WO{sub 4}){sub 2} crystals doped with up to 7.5 at.% Ho are grown by the Top Seeded Solution Growth-Slow Cooling method. The evolution of their unit cell parameters in dependence on the Ho doping and temperature is studied. The polarized low-temperature (6 K) optical absorption of the Ho{sup 3+} ion is investigated in detail to determine the energy of the Stark sub-levels. Room-temperature absorption, stimulated-emission and gain cross-section spectra of Ho:KY(WO{sub 4}){sub 2} crystals are derived for polarizations parallel to the principal optical axes, E||N{sub p}, N{sub m} and N{sub g}. The maximum absorption cross-section for the {sup 5}I{sub 8}→{sup 5}I{sub 7} transition is 1.60×10{sup −20} cm{sup 2} at 1961.0 nm and the maximum stimulated-emission cross-section for the {sup 5}I{sub 7}→{sup 5}I{sub 8} transition is 2.65×10{sup −20} cm{sup 2} at 2056.3 nm (for E||N{sub m}). The radiative lifetime of the upper laser level of the Ho{sup 3+} ion ({sup 5}I{sub 7}) amounts to 4.8 ms. Continuous-wave Ho{sup 3+} laser operation is achieved under in-band pumping by a Tm laser at 1946 nm. In the microchip configuration, the maximum output power reached 205 mW at 2105 nm with a slope efficiency as high as 85%.

  15. Flood-Inundation maps for the Hohokus Brook in Waldwick Borough, Ho-Ho-Kus Borough, and the Village of Ridgewood, New Jersey, 2014

    Science.gov (United States)

    Watson, Kara M.; Niemoczynski, Michal J.

    2015-07-20

    Digital flood-inundation maps for a 6-mile reach of the Hohokus Brook in New Jersey from White's Lake Dam in Waldwick Borough, through Ho-Ho-Kus Borough to Grove Street in the Village of Ridgewood were created by the U.S. Geological Survey (USGS) in cooperation with the New Jersey Department of Environmental Protection. The flood inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage on the Hohokus Brook at Ho-Ho-Kus, New Jersey (station number 01391000). Stage data at this streamgage may be obtained on the Internet from the USGS National Water Information System at http://waterdata.usgs.gov/nwis/uv?site_no=01391000 or the National Weather Service (NWS) Advanced Hydrologic Prediction Service at http://water.weather.gov/ahps2/hydrograph.php?gage=hohn4&wfo=okx.

  16. Slaďování pracovního a osobního života pracovníků

    OpenAIRE

    Šauerová, Martina

    2017-01-01

    Diplomová práce se zabývá tématem slaďování pracovního a osobního života ve vybrané společnosti. Práce je rozdělena do tří části – na teoretickou, analytickou a závěrečnou část. Teoretická část vysvětluje atraktivitu a důležitost tohoto tématu, popisuje jednotlivé nástroje umožňující slazení profesního a osobního života a zároveň poukazuje na možné komplikace jednotlivých přístupů, a to jak z pohledu zaměstnavatele, tak i zaměstnance. Analytická část zkoumá a následně vyhodnocuje současný sta...

  17. Measurement of absorbed dose for high energy electron using CaSO4: Tm-PTFE TLD

    International Nuclear Information System (INIS)

    Park, Myeong Hwan; Kim, Do Sung

    2000-01-01

    In this study, the highly sensitive CaSO 4 : Tm-PTFE TLDs has been fabricated for the purpose of measurement of high energy electron. CaSO 4 : Tm phosphor powder was mixed with polytetrafluoroethylene(PTFE) powder and moulded in a disk type(diameter 8.5mm, thickness 90mg/cm 2 ) by cold pressing. The absorbed dose distribution and ranges for high energy electron were measured by using the CaSO 4 : Tm-PTFE TLDs. The ranges determined were R 100 =3D14.5mm, R 50 =3D24.1mm and R p =3D31.8mm, respectively and the beam flatness, the variation of relative dose in 80% of the field size, was 4.5%. The fabricated CaSO 4 : Tm-PTFE TLDs may be utilized in radiation dosimetry for personal, absorbed dose and environmental monitoring.=20

  18. Comparison of a novel high-power blue diode laser (λ=442 nm) with Ho:YAG (λ=2100 nm), Tm fiber (λ=1940 nm), and KTP (λ=532 nm) lasers for soft tissue ablation

    Science.gov (United States)

    Vinnichenko, Victoriya; Kovalenko, Anastasiya; Arkhipova, Valeriya; Yaroslavsky, Ilya; Altshuler, Gregory; Gapontsev, Valentin

    2018-02-01

    Three lasers were directly compared, including the Ho:YAG laser (λ = 2100 nm), Tm fiber laser (λ = 1940 nm) operating in 3 different modes (CW, regular pulse, and super pulse), and blue diode laser (λ = 442 nm) for vaporization and coagulation efficiency for treating blood-rich soft tissues, ex vivo, in a porcine kidney model at quasi-contact cutting in water. In addition, experimental results were compared with published data on performance of KTP laser (λ = 532 nm) at similar experimental settings (Power = 60 W and cutting speed = 2 mm/s). Tm fiber laser in pulsed mode and blue laser produced highest vaporization rates of 3.7 and 3.4 mm3/s, respectively. Tm fiber laser (in both CW and pulsed modes) also produced the largest coagulation zone among the laser sources tested. A carbonization zone was observed for Tm fiber laser in CW and pulsed modes, as well as for the blue diode laser. Tm fiber laser in super-pulse mode and Ho:YAG laser both resulted in irregular coagulation zones without carbonization. Comparison with known data for KTP laser revealed that tissue effects of the blue laser are similar to that of the KTP laser. These results suggest that the combination of the two lasers (Tm fiber and blue diode) in one system may achieve high cutting efficiency and optimal coagulation for hemostasis during surgical treatment. Ex vivo testing of the combined system revealed feasibility of this approach. The combination of the CW Tm fiber laser (120W) and the blue diode laser (60W) emitting through a combination tip were compared with CW 120 W Tm fiber laser alone and 120 W Ho:YAG laser. Vaporization rates measured 34, 28, and 6 mm3/s, and coagulation zones measured 0.6, 1.3, and 1.7 mm, respectively. A carbonization zone was only observed with CW Tm fiber laser. The vaporization rate of combined CW Tm fiber laser / blue diode laser was comparable to published data for KTP laser for equivalent total power. Thus, high-power blue diode laser, Tm fiber laser, and

  19. The site of net absorption of Ca from the intestinal tract of growing pigs and effect of phytic acid, Ca level and Ca source on Ca digestibility.

    Science.gov (United States)

    González-Vega, J Caroline; Walk, Carrie L; Liu, Yanhong; Stein, Hans H

    2014-01-01

    An experiment was conducted to test the hypothesis that the standardised digestibility of Ca in calcium carbonate and Lithothamnium calcareum Ca is not different regardless of the level of dietary Ca, and that phytic acid affects the digestibility of Ca in these two ingredients to the same degree. The objectives were to determine where in the intestinal tract Ca absorption takes place and if there are measurable quantities of basal endogenous Ca fluxes in the stomach, small intestine or large intestine. Diets contained calcium carbonate or L. calcareum Ca as the sole source of Ca, 0% or 1% phytic acid and 0.4% or 0.8% Ca. A Ca-free diet was also formulated and used to measure endogenous fluxes and losses of Ca. Nine growing pigs (initial body weight 23.8 ± 1.3 kg) were cannulated in the duodenum and in the distal ileum, and faecal, ileal and duodenal samples were collected. Duodenal endogenous fluxes of Ca were greater (p calcareum Ca diets, but that was not the case if calcium carbonate was the source of Ca (interaction, p calcareum Ca was greater (p calcareum Ca. In conclusion, under the conditions of this experiment, standardised digestibility of Ca is not affected by the level of phytic acid, but may be affected by dietary Ca level depending on the Ca source. Calcium from calcium carbonate is mostly absorbed before the duodenum, but Ca from L. calcareum Ca is mostly absorbed in the jejunum and ileum.

  20. Decreasing extracellular Na+ concentration triggers inositol polyphosphate production and Ca2+ mobilization

    International Nuclear Information System (INIS)

    Smith, J.B.; Dwyer, S.D.; Smith, L.

    1989-01-01

    Removing extracellular Na+ (Na+o) evoked a large increase in cytosolic free Ca2+ concentration ([Ca2+]i in human skin fibroblasts. Decreasing [Na+]o from 120 to 14 mM caused the half-maximal peak increase in [Ca2+]i. Removing Na+o strongly stimulated 45 Ca2+ efflux and decreased total cell Ca2+ by about 40%. Bradykinin caused changes in [Ca2+]i, total Ca2+, and 45 Ca2+ fluxes similar to those evoked by removing Na+o. Prior stimulation of the cells with bradykinin prevented Na+o removal from increasing [Ca2+]i and vice versa. Na+o removal rapidly increased [ 3 H]inositol polyphosphate production. Loading the cells with Na+ had no effect on the increase in 45 Ca2+ efflux produced by Na+o removal. Therefore, decreasing [Na+]o probably stimulates a receptor(s) which is sensitive to extracellular, not intracellular, Na+. Removing Na+o also mobilized intracellular Ca2+ in smooth muscle and endothelial cells cultured from human umbilical and dog coronary arteries, respectively

  1. Návrh raketového motoru

    OpenAIRE

    Cejpek, Jakub

    2009-01-01

    Cílem této práce je navrhnout raketový motor na tuhou pohonnou hmotu s dostatečným výkonem pro vynesení zátěže o hmotnosti 500 gramů do výšky 1500 metrů. A dále navrhnout základní uspořádání rakety, která by tento motor využila. Návrh motoru se řeší nejprve teoreticky. Tedy bez ohledu na dostupnost konstrukčního materiálu, paliva a výrobních technologií. Po vyřešení této teoretické části je na se v řešení zohlední dostupnost výše zmíněných prostředků. To znamená nejprve určit vhodné a dostupn...

  2. Accelerated conventional temperature drying of 30mm thick rubberwood lumber

    Directory of Open Access Journals (Sweden)

    Suthon Srivaro1,

    2008-07-01

    Full Text Available Lumber drying is the most energy and time consuming process within the rubberwood lumber industry. The aim ofthis study was to develop an effective drying schedule for rubberwood lumber by accelerating the moisture movement out oflumber without degrading the lumber during drying. The study explored the effect of dry bulb temperature (60oC, 75oC and90oC, steaming at the beginning of drying, predrying of lumber prior to drying, and top loading of lumber on the dryingcharacteristics and lumber quality (bow, crook, twist, end splitting and color of 30mm thick rubberwood lumber under thetarget EMC at 4% and air velocity of 4m/s. Accelerated conventional temperature drying of lumber at 90oC reduced thedrying time by ~50% from 117 hours to 54 hours but increased the energy consumption by 22% with respect to the conventionaltemperature drying at 60oC. The average activation energy for drying was 26 kJ/mol. Drying temperature had verylittle effect on quality of lumber after drying (bow, crook, twist, end splitting and color. Steaming at the beginning of dryingand predrying of lumber prior to drying reduced and increased the percentage of end splitting, respectively. A top load ofabout 300 kg/m2 slightly decreased twist. Drying at higher temperatures produced more casehardening within the lumber butconditioning at higher temperatures was more effective in releasing the residual stress generated by drying. After conditioningat high temperatures prong of less than 0.5° casehardening was obtained.

  3. How Does the Ca2+-paradox Injury Induce Contracture in the Heart?—A Combined Study of the Intracellular Ca2+ Dynamics and Cell Structures in Perfused Rat Hearts—

    International Nuclear Information System (INIS)

    Mani, Hiroki; Tanaka, Hideo; Adachi, Tetsuya; Ikegawa, Masaya; Dai, Ping; Fujita, Naohisa; Takamatsu, Tetsuro

    2015-01-01

    The calcium (Ca 2+ )-paradox injury of the heart, induced by restoration of extracellular Ca 2+ after its short-term depletion, is known to provoke cardiomyocyte contracture. However, undetermined is how the Ca 2+ -paradox provokes such a distinctive presentation of myocytes in the heart. To address this, we imaged sequential intracellular Ca 2+ dynamics and concomitant structures of the subepicardial ventricular myocytes in fluo3-loaded, Langendorff-perfused rat hearts produced by the Ca 2+ paradox. Under rapid-scanning confocal microscopy, repletion of Ca 2+ following its depletion produced high-frequency Ca 2+ waves in individual myocytes with asynchronous localized contractions, resulting in contracture within 10 min. Such alterations of myocytes were attenuated by 5-mM NiCl 2 , but not by verapamil, SEA0400, or combination of ryanodine and thapsigargin, indicating a contribution of non-specific transmembrane Ca 2+ influx in the injury. However, saponin-induced membrane permeabilization of Ca 2+ showed no apparent contracture despite the emergence of high-frequency Ca 2+ waves, indicating an essential role of myocyte-myocyte and myocyte-extracellular matrix (ECM) mechanical connections in the Ca 2+ paradox. In immunohistochemistry Ca 2+ depletion produced separation of the intercalated disc that expresses cadherin and dissipation of β-dystroglycan located along the sarcolemma. Taken together, along with the trans-sarcolemmal Ca 2+ influx, disruption of cell-cell and cell-ECM connections is essential for contracture in the Ca 2+ -paradox injury

  4. Rates for some reactions involving 42Ca and 44Ca

    International Nuclear Information System (INIS)

    Cheng, C.W.; King, J.D.

    1980-01-01

    Ground-state reaction rates have been deduced from recent cross section measurements for the 42 CA(α, n) 45 Ti, 42 Ca(p, γ) 43 Sc, and 44 Ca(p, n) 44 Sc reactions. Comparison of these rates with those calculated from a statistical model of nuclear reactions. (Woosley et al) shows good agreement for the first two, but the 44 Ca(p, n) rate is more than a factor of 2 less than the theoretical prediction. Stellar reaction rates have been derived from the ground-state rates by multiplying the ground-state rates by the ratio of stellar to ground-state rates given by the statistical model. Both ground-state and stellar rates have been represented by analytic functions of the temperature. The role of these reactions in the approach to quasi-equilibrium during explosive silicon burning is discussed

  5. Analysis of transients aimed at assessing the feasibility of eliminating the HO-2 accident protection and the ''moderate leak'' SOB signal

    International Nuclear Information System (INIS)

    Sommer, J.

    1993-12-01

    Accidents and transient processes were analyzed in order to assess the feasibility of eliminating the 2nd level accident protection (HO-2). All analyses were performed in 3 alternatives, viz. for the normal performance of HO-2, for the HO-2 signals being transferred to the 1st level accident protection (HO-1), and for a complete elimination of HO-2. Transfer of HO-2 signals to HO-1 definitely brings about an improvement of the nuclear power plant operation safety. There is no evidence indicating that the safety would decrease intolerably if HO-2 were eliminated altogether. Elimination of the ''moderate leak'' safety system does not require any thermohydraulic analysis to be performed. 18 refs

  6. New therapeutic agent for radiation synovectomy - preparation of {sup 166}Ho-EDTMP-HA particle

    Energy Technology Data Exchange (ETDEWEB)

    Bai, H.; Jin, X.; Du, J.; Wang, F.; Chen, D.; Fan, H.; Cheng, Z.; Zhang, J. [China Institute of Atomic Energy, Beijing (Switzerland). Isotope Department

    1997-10-01

    In order to prepare new therapeutical agent for radiation synovectomy, Hydroxyapatite (HA) was labelled with {sup 166}Ho by EDTMP that had high affinity to HA particles. Radiolabelling of HA particles was divided into two steps, {sup 166}Ho-EDTMP was prepared first; then mixed with HA particles completely and vibrated for 15 minutes on the micromixer at room temperature, washed 3 times with deionized water. Radiolabelling particle was separated from free {sup 166}Ho via centrifugation to determine its radiolabelling efficiency. {sup 166}Ho-EDTMP-HA and {sup 166}Ho-EDTMP were injected into knee joint of normal rabbits respectively, every group was killed at different time postinjection, took out major organ and collected urine and blood, then weighted and determined their radio counts. HA particles, as a natural component of bone was known to have good compatibility with soft tissue and biodegrade into calcium and phosphate in vivo. It was readily prepared from common chemical and formed into particles of desired size range in a controlled process, it had high stability in vitro and vivo. Radiolabelling of HA particle with {sup 166}Ho by EDTMP was simple to perform and provides an excellent labelling yield that was more than 95% under the optimal labelling condition. The optimal labelling condition at room temperature was pH 6.0-8.0 and vibration time 15 minutes. The absorbed capacity of HA particle was 5 mg Ho/g HA particle and size of radiolabelling particle was at range of 2-5,{mu}m that is suitable for therapy of radiation synovectomy. {sup 166}Ho-EDTMP-HA particle demonstrated high in vitro stability in either normal saline or 1% BSA solution, but instability under extremely acidic condition (pH 1-2). The control studies performed with {sup 166}Ho-EDTMP not bound to HA particle provided information on the distribution of radioactivity that would occur upon leakage of the radiochemical compound from joint. Its short half-life, its extremely low leakage from the

  7. New therapeutic agent for radiation synovectomy - preparation of 166Ho-EDTMP-HA particle

    International Nuclear Information System (INIS)

    Bai, H.; Jin, X.; Du, J.; Wang, F.; Chen, D.; Fan, H.; Cheng, Z.; Zhang, J.

    1997-01-01

    In order to prepare new therapeutical agent for radiation synovectomy, Hydroxyapatite (HA) was labelled with 166 Ho by EDTMP that had high affinity to HA particles. Radiolabelling of HA particles was divided into two steps, 166 Ho-EDTMP was prepared first; then mixed with HA particles completely and vibrated for 15 minutes on the micromixer at room temperature, washed 3 times with deionized water. Radiolabelling particle was separated from free 166 Ho via centrifugation to determine its radiolabelling efficiency. 166 Ho-EDTMP-HA and 166 Ho-EDTMP were injected into knee joint of normal rabbits respectively, every group was killed at different time postinjection, took out major organ and collected urine and blood, then weighted and determined their radio counts. HA particles, as a natural component of bone was known to have good compatibility with soft tissue and biodegrade into calcium and phosphate in vivo. It was readily prepared from common chemical and formed into particles of desired size range in a controlled process, it had high stability in vitro and vivo. Radiolabelling of HA particle with 166 Ho by EDTMP was simple to perform and provides an excellent labelling yield that was more than 95% under the optimal labelling condition. The optimal labelling condition at room temperature was pH 6.0-8.0 and vibration time 15 minutes. The absorbed capacity of HA particle was 5 mg Ho/g HA particle and size of radiolabelling particle was at range of 2-5,μm that is suitable for therapy of radiation synovectomy. 166 Ho-EDTMP-HA particle demonstrated high in vitro stability in either normal saline or 1% BSA solution, but instability under extremely acidic condition (pH 1-2). The control studies performed with 166 Ho-EDTMP not bound to HA particle provided information on the distribution of radioactivity that would occur upon leakage of the radiochemical compound from joint. Its short half-life, its extremely low leakage from the joint and its even distribution throughout

  8. 45Ca distribution and transport in saponin skinned vascular smooth muscle

    International Nuclear Information System (INIS)

    Stout, M.A.; Diecke, F.P.

    1983-01-01

    45 Ca distribution and transport were studied in chemically skinned strips of caudal artery from Kyoto Wistar rats. Sarcolemmal membranes were made hyperpermeable by exposure for 60 min to solutions containing 0.1 mg/ml of saponin. Skinned helical strips responded with graded contractions to changes in ethylene glycol bis-(beta-aminoethyl ether)-N,N'-tetraacetic acid buffered free Ca solutions (10(-7) to 10(-5) M) and were sensitive to the Mg-ATP concentration. Tissues loaded in the presence of 10(-7) M Ca contracted in response to 10 mM caffeine. These experiments indicate the strips are skinned and possess a functional regulatory and contractile system and an intact Ca sequestering system. 45 Ca distributes in three compartments in skinned caudal artery strips. The Ca contents of two components are linear functions of the Ca-ethylene glycol bis-(beta-aminoethyl ether)-N,N'-tetraacetic acid concentration and desaturate at rapid rates. They correspond to the extracellular and cytoplasmic spaces. A significantly smaller component releases Ca at comparatively slower rates. 45 Ca uptake by the slow component consists of an ATP-dependent and an ATP-independent fraction. The 45 Ca content of the ATP-dependent fraction is a function of the free Ca concentration and is independent of the Ca-ethylene glycol bis-(beta-aminoethyl ether)-N,N'-tetraacetic acid concentration. Its content was enhanced by oxalate and was abolished by Triton X-100 skinning solutions. The ATP-independent component was not affected by Triton X-100 skinning and may represent Ca binding to cytoplasmic molecules and structures. The sequestered Ca was released with caffeine or Ca but not by epinephrine. The observations indicate that the sarcoplasmic reticulum and mitochondria of vascular smooth muscle strips skinned with saponin retain their functional integrity after saponin skinning

  9. Characterization of the ER-Targeted Low Affinity Ca2+ Probe D4ER

    Directory of Open Access Journals (Sweden)

    Elisa Greotti

    2016-09-01

    Full Text Available Calcium ion (Ca2+ is a ubiquitous intracellular messenger and changes in its concentration impact on nearly every aspect of cell life. Endoplasmic reticulum (ER represents the major intracellular Ca2+ store and the free Ca2+ concentration ([Ca2+] within its lumen ([Ca2+]ER can reach levels higher than 1 mM. Several genetically-encoded ER-targeted Ca2+ sensors have been developed over the last years. However, most of them are non-ratiometric and, thus, their signal is difficult to calibrate in live cells and is affected by shifts in the focal plane and artifactual movements of the sample. On the other hand, existing ratiometric Ca2+ probes are plagued by different drawbacks, such as a double dissociation constant (Kd for Ca2+, low dynamic range, and an affinity for the cation that is too high for the levels of [Ca2+] in the ER lumen. Here, we report the characterization of a recently generated ER-targeted, Förster resonance energy transfer (FRET-based, Cameleon probe, named D4ER, characterized by suitable Ca2+ affinity and dynamic range for monitoring [Ca2+] variations within the ER. As an example, resting [Ca2+]ER have been evaluated in a known paradigm of altered ER Ca2+ homeostasis, i.e., in cells expressing a mutated form of the familial Alzheimer’s Disease-linked protein Presenilin 2 (PS2. The lower Ca2+ affinity of the D4ER probe, compared to that of the previously generated D1ER, allowed the detection of a conspicuous, more clear-cut, reduction in ER Ca2+ content in cells expressing mutated PS2, compared to controls.

  10. DICOM to print, 35-mm slides, web, and video projector: tutorial using Adobe Photoshop.

    Science.gov (United States)

    Gurney, Jud W

    2002-10-01

    Preparing images for publication has dealt with film and the photographic process. With picture archiving and communications systems, many departments will no longer produce film. This will change how images are produced for publication. DICOM, the file format for radiographic images, has to be converted and then prepared for traditional publication, 35-mm slides, the newest techniques of video projection, and the World Wide Web. Tagged image file format is the common format for traditional print publication, whereas joint photographic expert group is the current file format for the World Wide Web. Each medium has specific requirements that can be met with a common image-editing program such as Adobe Photoshop (Adobe Systems, San Jose, CA). High-resolution images are required for print, a process that requires interpolation. However, the Internet requires images with a small file size for rapid transmission. The resolution of each output differs and the image resolution must be optimized to match the output of the publishing medium.

  11. Incommensurate magnetic modulations in the magnetic superconductor HoNi2B2C

    International Nuclear Information System (INIS)

    Schneider, M.; Zaharko, O.; Keller, L.; Allenspach, P.; Kreyssig, A.; Canfield, P.C.

    2006-01-01

    Full text: The borocarbide HoNi 2 B 2 C is an unconventional superconductor of particular interest, since long-range magnetism coexists and competes with superconductivity on a common energy range [1]. Our study is based on high quality single crystals of 11 B-substituted HoNi 2 B 2 C. The neutron diffraction investigations are devoted to two issues of specific relevance to HoNi 2 B 2 C. Firstly, the near re-entrant phase between 5K 2 B 2 C is more complicated than proposed so fare [2]. Furthermore we performed a spherical neutron polarimetry experiment to determine the two ICM magnetic structures of HoNi 2 B 2 C and neutron spectroscopy investigations to obtain the microscopic magnetic coupling parameters. All these studies resulted in quite a consistent and complete picture of magnetism in HoNi 2 B 2 C, however, we could not find clear evidence for a strong interaction between superconductivity and magnetism. (author)

  12. Diagnostika diafragmového výboje v kapalinách

    OpenAIRE

    Hlavatá, Lucie

    2009-01-01

    Hlavním cílem této práce je diagnostika diafragmového výboje v kapalinách. Ačkoli byla v posledních letech objevena celá řada aplikací elektrického výboje v kapalinách, vlastní mechanismus vzniku tohoto výboje není dosud znám. Z těchto důvodů se tato práce zaměřila na studium dějů předcházejících samotnému zapálení výboje, zápalného napětí, samotného výboje jak v oblastech náhodného průrazu tak i pravidelnému výboji. Použitím roztoků dvou anorganických solí o různých vodivostech práce zkoumal...

  13. First Calorimetric Measurement of OI-line in the Electron Capture Spectrum of $^{163}$Ho

    CERN Document Server

    Ranitzsch, P. C. -O.; Wegner, M.; Kempf, S.; Fleischmann, A.; Enss, C.; Gastaldo, L.; Herlert, A.; Johnston, K.

    2014-01-01

    The isotope $^{163}$Ho undergoes an electron capture process with a recommended value for the energy available to the decay, $Q_{\\rm EC}$, of about 2.5 keV. According to the present knowledge, this is the lowest $Q_{\\rm EC}$ value for electron capture processes. Because of that, $^{163}$Ho is the best candidate to perform experiments to investigate the value of the electron neutrino mass based on the analysis of the calorimetrically measured spectrum. We present for the first time the calorimetric measurement of the atomic de-excitation of the $^{163}$Dy daughter atom upon the capture of an electron from the 5s shell in $^{163}$Ho, OI-line. The measured peak energy is 48 eV. This measurement was performed using low temperature metallic magnetic calorimeters with the $^{163}$Ho ion implanted in the absorber. We demonstrate that the calorimetric spectrum of $^{163}$Ho can be measured with high precision and that the parameters describing the spectrum can be learned from the analysis of the data. Finally, we dis...

  14. Assessing depression outcome in patients with moderate dementia: sensitivity of the HoNOS65+ scale.

    Science.gov (United States)

    Canuto, Alessandra; Rudhard-Thomazic, Valérie; Herrmann, François R; Delaloye, Christophe; Giannakopoulos, Panteleimon; Weber, Kerstin

    2009-08-15

    To date, there is no widely accepted clinical scale to monitor the evolution of depressive symptoms in demented patients. We assessed the sensitivity to treatment of a validated French version of the Health of the Nation Outcome Scale (HoNOS) 65+ compared to five routinely used scales. Thirty elderly inpatients with ICD-10 diagnosis of dementia and depression were evaluated at admission and discharge using paired t-test. Using the Brief Psychiatric Rating Scale (BPRS) "depressive mood" item as gold standard, a receiver operating characteristic curve (ROC) analysis assessed the validity of HoNOS65+F "depressive symptoms" item score changes. Unlike Geriatric Depression Scale, Mini Mental State Examination and Activities of Daily Living scores, BPRS scores decreased and Global Assessment Functioning Scale score increased significantly from admission to discharge. Amongst HoNOS65+F items, "behavioural disturbance", "depressive symptoms", "activities of daily life" and "drug management" items showed highly significant changes between the first and last day of hospitalization. The ROC analysis revealed that changes in the HoNOS65+F "depressive symptoms" item correctly classified 93% of the cases with good sensitivity (0.95) and specificity (0.88) values. These data suggest that the HoNOS65+F "depressive symptoms" item may provide a valid assessment of the evolution of depressive symptoms in demented patients.

  15. Magnetostriction of Hexagonal HoMnO3 and YMnO3 Single Crystals

    Science.gov (United States)

    Pavlovskii, N. S.; Dubrovskii, A. A.; Nikitin, S. E.; Semenov, S. V.; Terent'ev, K. Yu.; Shaikhutdinov, K. A.

    2018-03-01

    We report on the magnetostriction of hexagonal HoMnO3 and YMnO3 single crystals in a wide range of applied magnetic fields (up to H = 14 T) at all possible combinations of the mutual orientations of magnetic field H and magnetostriction Δ L/L. The measured Δ L/L( H, T) data agree well with the magnetic phase diagram of the HoMnO3 single crystal reported previously by other authors. It is shown that the nonmonotonic behavior of magnetostriction of the HoMnO3 crystal is caused by the Ho3+ ion; the magnetic moment of the Mn3+ ion parallel to the hexagonal crystal axis. The anomalies established from the magnetostriction measurements of HoMnO3 are consistent with the phase diagram of these compounds. For the isostructural YMnO3 single crystal with a nonmagnetic rare-earth ion, the Δ L/L( H, T) dependences are described well by a conventional quadratic law in a wide temperature range (4-100 K). In addition, the magnetostriction effect is qualitatively estimated with regard to the effect of the crystal electric field on the holmium ion.

  16. Optical properties of GaS:Ho3+ and GaS:Tm3+ single crystals

    International Nuclear Information System (INIS)

    Jin, Moon-Seog; Kim, Chang-Dae; Kim, Wha-Tek

    2004-01-01

    GaS:Ho 3+ and GaS:Tm 3+ single crystals were grown by using the chemical transport reaction method. We measured the optical absorption, the infra-red absorption, and the photoluminescence spectra of the single crystals. The direct and the indirect energy band gaps of the single crystals at 13 K were identified. Infra-red absorption peaks at 6 K appeared in the single crystals. Broad emission bands at 6 K were observed at 464 nm and 580 nm for GaS:Ho 3+ and 462 nm and 581 nm for GaS:Tm 3+ . These broad emission bands were identified as originating from donor-acceptor pair recombinations. Sharp emission peak groups were observed near 435 nm, 495 nm, and 660 nm for GaS:Ho 3+ and near 672 nm for GaS:Tm 3+ . These sharp emission peak groups were identified as being due to the electron transitions between the energy levels of Ho 3+ and Tm 3+ . Especially, white photoluminescence was obtained in the GaS:Ho 3+ single crystal.

  17. Hepatitis B Stigma and Knowledge among Vietnamese in Ho Chi Minh City and Chicago

    Directory of Open Access Journals (Sweden)

    Lan Dam

    2016-01-01

    Full Text Available Stigma regarding viral hepatitis and liver disease has psychological and social consequences including causing negative self-image, disrupting relationships, and providing a barrier to prevention, testing, and treatment. The aim of this study was to characterize and compare HBV knowledge and stigma in Vietnamese in Ho Chi Minh City and Chicago and to begin to evaluate the cultural context of HBV stigma. Methods. A written survey including knowledge questions and a validated HBV stigma questionnaire was distributed to Vietnamese in Ho Chi Minh City and Chicago. 842 surveys from Ho Chi Minh City and 170 from Chicago were analyzed. Results. Vietnamese living in Chicago had better understanding of HBV transmission and that HBV can cause chronic infection and liver cancer. Vietnamese in Chicago had higher stigma scores on a broad range of items including guilt and shame about HBV and were more likely to feel that persons with HBV can bring harm to others and should be isolated. Conclusions. Vietnamese in Ho Chi Minh City and Chicago have knowledge deficits about HBV, particularly regarding modes of transmission. Persons in Ho Chi Minh City expressed lower levels of HBV stigma than Vietnamese living in Chicago, likely reflecting changing cultural attitudes in Vietnam. Culturally appropriate educational initiatives are needed to address the problem of HBV stigma.

  18. Spectroscopic investigation of 2.0 μm emission in Ho3+-doped fluoroindate glasses

    International Nuclear Information System (INIS)

    Oliveira, S L; Bell, M J V; Florez, A; Nunes, L A O

    2006-01-01

    In this paper we report the optical characterization of Ho 3+ -doped fluoroindate glasses with the following composition (40 - x)InF 3 -20SrF 2 -16BaF 2 -20ZnF 2 -2GdF 3 -2NaF-xHoF 3 with x = 1.0, 2.0, 2.5, 3.0, 4.0, 5.0, 6.0, 8.0 and 9.0 mol%. This investigation was done by means of absorption, fluorescence and lifetime measurements. The phenomenological intensity parameters Ω λ (λ = 2, 4, 6) were calculated using the standard Judd-Ofelt theory. In order to evaluate potential applications of the 5 I 7 → 5 I 8 Ho 3+ emission at 2.0 μm, the radiative lifetime, total transition rate and emission cross section were determined. The effect of Ho 3+ concentration on the fluorescence intensity and lifetimes was analysed. It was concluded that the non-radiative losses of the 5 I 7 level are mainly due to energy migration among Ho 3+ ions followed by energy transfer to quenching impurities

  19. Clinical Presentation Resembling Mucosal Disease Associated with 'HoBi'-like Pestivirus in a Field Outbreak.

    Science.gov (United States)

    Weber, M N; Mósena, A C S; Simões, S V D; Almeida, L L; Pessoa, C R M; Budaszewski, R F; Silva, T R; Ridpath, J F; Riet-Correa, F; Driemeier, D; Canal, C W

    2016-02-01

    The genus Pestivirus of the family Flaviviridae consists of four recognized species: Bovine viral diarrhoea virus 1 (BVDV-1), Bovine viral diarrhoea virus 2 (BVDV-2), Classical swine fever virus (CSFV) and Border disease virus (BDV). Recently, atypical pestiviruses ('HoBi'-like pestiviruses) were identified in batches of contaminated foetal calf serum and in naturally infected cattle with and without clinical symptoms. Here, we describe the first report of a mucosal disease-like clinical presentation (MD) associated with a 'HoBi'-like pestivirus occurring in a cattle herd. The outbreak was investigated using immunohistochemistry, antibody detection, viral isolation and RT-PCR. The sequence and phylogenetic analysis of 5'NCR, N(pro) and E2 regions of the RT-PCR positive samples showed that four different 'HoBi'-like strains were circulating in the herd. The main clinical signs and lesions were observed in the respiratory and digestive systems, but skin lesions and corneal opacity were also observed. MD characteristic lesions and a pestivirus with cytopathic biotype were detected in one calf. The present study is the first report of a MD like presentation associated with natural infection with 'HoBi'-like pestivirus. This report describes the clinical signs and provides a pathologic framework of an outbreak associated with at least two different 'HoBi'-like strains. Based on these observations, it appears that these atypical pestiviruses are most likely underdiagnosed in Brazilian cattle. © 2014 Blackwell Verlag GmbH.

  20. Identification of Natural Infections in Sheep/Goats with HoBi-like Pestiviruses in China.

    Science.gov (United States)

    Shi, H; Kan, Y; Yao, L; Leng, C; Tang, Q; Ji, J; Sun, S

    2016-10-01

    The natural infections of HoBi-like pestiviruses in cattle have been reported in South America, Europe and Asia. In China, although the detections of HoBi-like pestivirus have been reported, the epidemiological investigation was limited. From January 2014 to October 2015, several flocks of sheep/goats in Henan province in central China suffered respiratory diseases which were recovered slowly after antibiotics treatment. To test whether it is the HoBi-like pestivirus caused this symptom, 49 serum samples and 22 nasal swabs were then collected for analysis by serology and RT-PCR. Serological result revealed that prevalence of pestivirus in small ruminants was 12.2% (6/49) in central China. Sequence analysis of partial 5'-UTR nucleotides of pestivirus-positive samples suggested that HoBi-like pestivirus might have circulated in sheep/goats of China for a period and have evolved into new genotype clusters. It is apparent that the study provides the molecular evidence of natural infections in goat/sheep species with HoBi-like pestiviruses in China. © 2016 Blackwell Verlag GmbH.

  1. 1.5 W high efficiency and tunable single-longitudinal-mode Ho:YLF ring laser based on Faraday effect.

    Science.gov (United States)

    Wu, Jing; Ju, Youlun; Dai, Tongyu; Yao, Baoquan; Wang, Yuezhu

    2017-10-30

    We demonstrated an efficient and tunable single-longitudinal-mode Ho:YLF ring laser based on Faraday effect for application to measure atmospheric carbon dioxide (CO 2 ). Single-longitudinal-mode power at 2051.65 nm achieved 528 mW with the slope efficiency of 39.5% and the M 2 factor of 1.07, and the tunable range of about 178 GHz was obtained by inserting a Fabry-Perot (F-P) etalon with the thickness of 0.5 mm. In addition, the maximum single-longitudinal-mode power reached 1.5 W with the injected power of 528 mW at 2051.65 nm by master oscillator power amplifier (MOPA) technique. High efficiency and tunable single-longitudinal-mode based on Faraday effect around 2 μm has not been reported yet to the best of our knowledge.

  2. Pokročilé možnosti tvarování datového toku v OS Linux pro sítě 802.3 a 802.11

    OpenAIRE

    Pánek, Michal

    2013-01-01

    Táto bakalárska práca sa zaoberá možnosťami tvarovania a kontroly dátového toku, v operačnom systéme Linux. Prvá časť práce sa zaoberá preskúmaním jednotlivých ná- strojov potrebných pre prácu s dátovým tokom. Druhá časť práce sa zaoberá metodamy určenými na tvarovanie dátového toku. Z tých boli vybrané a popísané metody, určené pre použitie v štandartoch 802.3 a 802.11. Práca sa v druhej časti zamerala na me- tody Hierarchical Token Bucket a Class-based queueing. Tretia časť práce je praktic...

  3. Dosimetric study of the 15 mm ROPES eye plaque

    International Nuclear Information System (INIS)

    Granero, D.; Perez-Calatayud, J.; Ballester, F.; Casal, E.; Frutos, J.M. de

    2004-01-01

    The main aim of this paper is to make a study of dose-rate distributions obtained around the 15 mm, radiation oncology physics and engineering services, Australia (ROPES) eye plaque loaded with 125 I model 6711 radioactive seeds. In this study, we have carried out a comparison of the dose-rate distributions obtained by the algorithm used by the Plaque Simulator (PS) (BEBIG GmbH, Berlin, Germany) treatment planning system with those obtained by means of the Monte Carlo method for the ROPES eye plaque. A simple method to obtain the dose-rate distributions in a treatment planning system via the superposition of the dose-rate distributions of a seed placed in the eye plaque has been developed. The method uses eye plaque located in a simplified geometry of the head anatomy and distributions obtained by means of the Monte Carlo code GEANT4. The favorable results obtained in the development of this method suggest that it could be implemented on a treatment planning system to improve dose-rate calculations. We have also found that the dose-rate falls sharply along the eye and that outside the eye the dose-rate is very low. Furthermore, the lack of backscatter photons from the air located outside the eye-head phantom produces a dose reduction negligible for distances from the eye-plaque r<1 cm but reaches up to 20% near the air-eye interface. Results showed that the treatment planning system lacks accuracy around the border of the eye (in the sclera and the surrounding area) due to the simplicity of the algorithm used. The BEBIG treatment planning system uses a global attenuation factor that takes into account the effect of the eye plaque seed carrier and the lack of backscatter photons caused by the metallic cover, which in the case of a ROPES eye plaque has a default value of T=1 (no correction). In the present study, a global attenuation factor T=0.96 and an air-interface correction factor which improve on treatment planning system calculations were obtained

  4. Crystal structure of RCoIn5 (R - Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Y) and R2CoIn8 (R - Ce, Pr, Nd, Sm, Gd, Dy, Ho, Er, Tm, Y) compounds

    International Nuclear Information System (INIS)

    Kalychak, Ya.M.; Zaremba, V.I.; Baranyak, V.M.; Bruskov, V.A.; Zavalij, P.Yu.

    1989-01-01

    Usng X-ray diffraction method of monocrystal, crystal structure of HoCoIn 5 compound belonging to the HoCoGa 5 structural type is determined. Using the method of powder belonging of CeCoIn 5 structure to the HoCoGa 5 structural type is confirmed. Isostructural compounds with Y, Pr, Nd, Sm, Gd, Tb, Dy are detected. Their lattice periods are determined. Using the method of powder belonging of Ce 2 CoIn 8 compound structure to Ho 2 CoGa 8 structural type is determined. Isostructural compounds with Y, Pr, Nd, Sm, Gd, Dy, Ho, Er, Tm are detected and their lattice periods are determined

  5. 77 FR 70460 - Notice of Intent To Prepare an Environmental Impact Statement for the Proposed Ho-Chunk Nation...

    Science.gov (United States)

    2012-11-26

    ... Impact Statement for the Proposed Ho-Chunk Nation Beloit Casino Project, City of Beloit, Rock County, WI...) application for a proposed 33-acre fee-to-trust transfer and casino project to be located in the City of... address, and ``DEIS Scoping Comments, Ho-Chunk Nation Beloit Casino Project'' on the first page of your...

  6. Hydrothermal synthesis of HoMn{sub 2}O{sub 5} nanorods and their size-dependent magnetic properties

    Energy Technology Data Exchange (ETDEWEB)

    Lv, Yichao; Wu, Songping, E-mail: chwsp@scut.edu.cn; Xu, Rui

    2017-03-01

    The HoMn{sub 2}O{sub 5} nanorods were synthesized by a surfactant-assisted hydrothermal process. The length of nanorods is readily controllable with basically constant diameter. HoMn{sub 2}O{sub 5} nanorods show recognizable divagation at T{sub N}(Ho) of 13 K between FC and ZFC curve due to the contribution of the magnetic ordering of holmium. Size-dependent magnetic properties (i.e. a critical length for magnetization) of HoMn{sub 2}O{sub 5} nanorods can be ascribed to the competition between surface strain and uncompensated spin at the surface. - Highlights: • HoMn{sub 2}O{sub 5} nanorods were synthesized by a surfactant-assisted hydrothermal route. • HoMn{sub 2}O{sub 5} nanorods show recognizable divagation at T{sub N}(Ho) of 13 K between FC and ZFC. • Size-dependent magnetic properties of HoMn{sub 2}O{sub 5} nanorods can be observed.

  7. Modulation of cGMP by human HO-1 retrovirus gene transfer in pulmonary microvessel endothelial cells.

    Science.gov (United States)

    Abraham, Nader G; Quan, Shuo; Mieyal, Paul A; Yang, Liming; Burke-Wolin, Theresa; Mingone, Christopher J; Goodman, Alvin I; Nasjletti, Alberto; Wolin, Michael S

    2002-11-01

    Carbon monoxide (CO) stimulates guanylate cyclase (GC) and increases guanosine 3',5'-cyclic monophosphate (cGMP) levels. We transfected rat-lung pulmonary endothelial cells with a retrovirus-mediated human heme oxygenase (hHO)-1 gene. Pulmonary cells that expressed hHO-1 exhibited a fourfold increase in HO activity associated with decreases in the steady-state levels of heme and cGMP without changes in soluble GC (sGC) and endothelial nitric oxide synthase (NOS) proteins or basal nitrite production. Heme elicited significant increases in CO production and intracellular cGMP levels in both pulmonary endothelial and pulmonary hHO-1-expressing cells. N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of NOS, significantly decreased cGMP levels in heme-treated pulmonary endothelial cells but not heme-treated hHO-1-expressing cells. In the presence of exogenous heme, CO and cGMP levels in hHO-1-expressing cells exceeded the corresponding levels in pulmonary endothelial cells. Acute exposure of endothelial cells to SnCl2, which is an inducer of HO-1, increased cGMP levels, whereas chronic exposure decreased heme and cGMP levels. These results indicate that prolonged overexpression of HO-1 ultimately decreases sGC activity by limiting the availability of cellular heme. Heme activates sGC and enhances cGMP levels via a mechanism that is largely insensitive to NOS inhibition.

  8. Mixed phase in cubic and hexagonal HoMn2111Cd PAC and 119Sn, 57Fe Moessbauer studies

    International Nuclear Information System (INIS)

    Cottenier, S.; Meersschaut, J.; Demuynck, S.; Swinnen, B.; Rots, M.

    1998-01-01

    Hyperfine parameters on 57 Fe, 119 Sn and 111 Cd substituted into the Mn sublattice were measured by Moessbauer and PAC spectroscopies. From these results it is tentatively concluded that C15 and C14 HoMn 2 are mixed-phase compounds. In C14 HoMn 2 there is no (or small) moment on the 2a site. (orig.)

  9. Thermoelastic properties of ScB2, TiB2, YB4 and HoB4

    DEFF Research Database (Denmark)

    Waskowska, A.; Gerward, L.; Staun Olsen, J.

    2011-01-01

    (4)GPa). No pressure-induced phase transformations are observed in any of the above borides up to about 20GPa. A continuous temperature-driven orthorhombic distortion is observed for HoB4 below 285K. Values of the thermal expansion coefficient are reported for ScB2 and HoB4 at 293, 200 and 100K...

  10. Antigenic differences between bovine viral diarrhea viruses and HoBi virus: Possible impacts on diagnosis and control

    Science.gov (United States)

    Compare antigenic differences between HoBi virus and BVDV strains that might impact on diagnostics and control. Eighteen non-cytopathic isolates of pestiviruses including the 5 genotypic groups (BVDV1a-c, BVDV2, BDV) and HoBi virus, were tested using antigen capture enzyme-linked immunosorbent assay...

  11. Lack of evidence for the presence of emerging HoBi-like viruses in North American fetal bovine serum lots.

    Science.gov (United States)

    The detection of HoBi-like virus in fetal bovine serum (FBS) labeled as United States of America (USA) origin, but packaged in Europe, raised concerns that HoBi-like virus may have entered the USA. In this study, 90 lots of FBS originating in North America (NA) were screened for pestivirus antigen ...

  12. Calibration of flavour tagging with B+ -> J/psi(mm)K+ and B0 ->J/psi(mm)K* control channels at LHCb

    CERN Document Server

    Calvi, M; Leroy, O; Musy, M; Poss, S; Vecchi, S

    2009-01-01

    B+ -> J/psi(mm)K+ and B0 ->J/psi(mm)K* are suitable control channels for the calibration of flavour tagging for CP measurements in Bs ->J/psi(mm) phi and B0 ->J/psi(mm)KS channels; in the first case if opposite side tagging only is considered. In this note we describe the calibration of the probability of mistag performed with B+ ->J/psi(mm)K+ events and the measurement of the mistag performed with B0 ->J/psi(mm)K* events in a fit to flavour oscillation as a function of proper time. Models are developed to extract this information from selected events taking into account different background components. An expected statistical sensitivity on the average opposite side mistag rate sigma(wOS)/ wOS = 0.3 % is obtained for B0 ->J/psi(mm)K* events, in 2 fb-1 of data.

  13. Crystal fields in Sc, Y, and the heavy-rare-earth metals Tb, Dy, Ho, Er, Tm, and Lu

    International Nuclear Information System (INIS)

    Touborg, P.

    1977-01-01

    Experimental investigations of the magnetic poperties of dilute alloys of the rare-earth solutes Tb, Dy, Ho, Er, and Tm in the nonmagnetic hosts Lu, Y, and Sc have been performed. These measurements, which include and supplement earlier published results, have been analyzed and crystal-field parameters for all these 15 alloy systems deduced. The consistency of the parameters was confirmed by a variety of magnetic measurements, including neutron spectroscopy. Crystal-field parameters have also been derived for the ions in pure magnetic rare-earth metals and their alloys using the results for the dilute alloys supplemented with paramagnetic measurements up to high temperatures on the concentrated systems. Mean values and standard deviations of the higher-order crystal-field parameters for all Y and Lu alloys are B 40 /β = 6.8 +- 0.9 K, B 60 /γ = 13.6 +- 0.7 K, and B 66 /γ = (9.7 +- 1.1) B 60 /γ. These values: with the inaccuracies somewhat increased: are expected to be representative also for the magnetic rare-earth metals. For rare-earth ions in the Sc host the values B 40 /β = 9.9 +- 1.9 K, B 60 /γ = 19.8 +- 1.5 K, and B 66 /γ = (9.4 +- 0.9) B 60 /γ were deduced. B 20 /α is a host-sensitive parameter which has the average values of -102.7, -53.4, and 29.5 K for rare-earth ions in Y, Lu, and Sc, respectively. There is also evidence that this parameter varies with the solute. B 20 /α for ions in the pure magnetic rare-earth metals and their alloys shows a linear variation with c/a ratio characteristic of each ion. The results indicate a contribution from anisotropic exchange to the high-temperature paramagnetic anisotropy of approximately 20% for Tb, Dy, Ho, and Er, and approximately 10% for Tm

  14. Standardization Of 166mHo Using Merlin Gerin Ionization Chamber System

    International Nuclear Information System (INIS)

    Nazaroh; Chandra; Hermawan; Juita Erni

    2000-01-01

    Standardization of 166m Ho using Merlin Gerin ionization chamber system has been carried out. Solution of 166m Ho was obtained from ETL-Japan. Activity measurement of 166m Ho was done before and after preparation. The result of activity measurement by P3KRBiN before preparation was (134.47±0.4) kBq/g, and after preparation was (131.98±1.85) kBq/g, at reference time, 1 March 1999. The ETL's result was (130.4±0.4) kBq/g, at the same reference time. The difference between P3KRBiN's (without uncertainty) and ETL's measurement result was 1.2% and if the uncertainty was included, both measurements was agreed

  15. VUV photoionization cross sections of HO2, H2O2, and H2CO.

    Science.gov (United States)

    Dodson, Leah G; Shen, Linhan; Savee, John D; Eddingsaas, Nathan C; Welz, Oliver; Taatjes, Craig A; Osborn, David L; Sander, Stanley P; Okumura, Mitchio

    2015-02-26

    The absolute vacuum ultraviolet (VUV) photoionization spectra of the hydroperoxyl radical (HO2), hydrogen peroxide (H2O2), and formaldehyde (H2CO) have been measured from their first ionization thresholds to 12.008 eV. HO2, H2O2, and H2CO were generated from the oxidation of methanol initiated by pulsed-laser-photolysis of Cl2 in a low-pressure slow flow reactor. Reactants, intermediates, and products were detected by time-resolved multiplexed synchrotron photoionization mass spectrometry. Absolute concentrations were obtained from the time-dependent photoion signals by modeling the kinetics of the methanol oxidation chemistry. Photoionization cross sections were determined at several photon energies relative to the cross section of methanol, which was in turn determined relative to that of propene. These measurements were used to place relative photoionization spectra of HO2, H2O2, and H2CO on an absolute scale, resulting in absolute photoionization spectra.

  16. House of Quality (HoQ) as a tool for improvement customer satisfaction

    International Nuclear Information System (INIS)

    Fazila Said; Noriah Mod Ali; Siti Mariam Ibrahim

    2010-01-01

    Full-text: Improvements to the customer satisfaction level is an important agenda today for the preservation of a quality certification. This study shows where the critical attributes or Voice of Customers, VOC-interest analysis of the results of Importance Performance Analysis (IPA). Questionnaires from our four customer service centers at Malaysian Nuclear Agency has been used in developing the House of Quality (HoQ). The innovation of HoQ is one of the simple and attractive services that display comprehensive information covering the needs of customers (VOC), the technical response, the correlation of technical, communication matrix, technical and planning division. Therefore, the information obtained from HoQ can be used in assisting the top management planning in accordance with the priority improvement activities to improve customer satisfaction levels in the near future. (author)

  17. Development of radioactive 166Ho-coated balloon and its dose estimation

    International Nuclear Information System (INIS)

    Park, K. B.; Kim, K. H.; Hong, Y. D.; Park, E. W.

    2000-01-01

    The use of balloon with radioisotope is a promising method to prevent restenosis after transluminal coronary arterial angioplasty or stent implantation. In this study, we have developed a new radioactive coated balloon, which is prepared by coating the surface of existing balloon with 166 Ho instead of being filled with beta sources which emit high energy beta-particles for the purpose of the delivery of sufficient radiation to the vessel wall. To estimate the safety of 166 Ho-coated balloon, leaching test and radiation resistance test of the balloon were performed. The absorbed dose distributions around the 166 Ho-coated balloon were estimated by means of Monte Carlo simulation and the initial activities for optimal therapeutic regimen were determined on the basis of this results

  18. Pohon pásového dopravníku pro transport uhlí

    OpenAIRE

    Kliš, Kamil

    2013-01-01

    Diplomová práce se zabývá návrhem pohonu pásového dopravníku pro transport uhlí. Práce obsahuje nezbytné výpočty dle norem potřebné k určení vhodných komponentů pásového dopravníku. Cílem diplomové práce bylo navrhnout pohon pásového dopravníku, všech jeho potřebných komponentů včetně návrhem rámu pohonu a vytvoření výkresové dokumentace. This diploma thesis deals with designing a drivetrain for a coal belt conveyor. Thesis contains necessary calculations according to norms needed for dete...

  19. Podnikatelský plán výrobního podniku

    OpenAIRE

    Borovská, Veronika

    2010-01-01

    V této diplomové práci je zpracován podnikatelský záměr výrobního podniku. Na základě teoretických poznatků získaných během studií a zjištěných skutečností, obsahuje návrh založení firmy a jejího případného umístění na trhu. This master’s thesis deals with business plan of production company. Based on the theoretical pieces of knowledges acquired during studies and discovered facts, it contains the proposal of establishment of the company and its conceivable positioning on the market. A...

  20. Magnetic properties of HoVOΛ4 in high magnetic fields

    International Nuclear Information System (INIS)

    Andronenko, S.I.; Bazhan, A.N.; Ioffe, V.A.; Udalov, Yu.P.

    1985-01-01

    Values magnetization and susceptibility of HoVO 4 , Van Vleck paramagnetic are specified in the 4.2-40 K temperature range and magnetic fields up to 50 kOe. Magnetic properties of HoVO 4 are analyzed using a theoretical model in which the interaction of rare earth ions with the crystal- and magnetic fields is considered. A possibility of rare earth ion interaction with the Bsub(1g), Bsub(2g), Asub(1g) symmetry deformations is also considered. It is stated that magnetic properties of HoVO 4 are completely explained within the frames of the crystal field model; the rare earth ion interactions with deformations are insignificant. Anisotropy of magnetization in the (001) plane is determined by the crystal field B 4 4 , B 6 4 constants; the constants being shown to be positive

  1. Momentum and charge transport in non-relativistic holographic fluids from Hořava gravity

    Energy Technology Data Exchange (ETDEWEB)

    Davison, Richard A. [Department of Physics, Harvard University, Cambridge, MA 02138 (United States); Grozdanov, Sašo [Instituut-Lorentz for Theoretical Physics, Leiden University, Niels Bohrweg 2, Leiden 2333 CA (Netherlands); Janiszewski, Stefan [Department of Physics and Astronomy, University of Victoria, Victoria, BC, V8W 3P6 (Canada); Kaminski, Matthias [Department of Physics and Astronomy, University of Alabama, Tuscaloosa, AL 35487 (United States)

    2016-11-28

    We study the linearized transport of transverse momentum and charge in a conjectured field theory dual to a black brane solution of Hořava gravity with Lifshitz exponent z=1. As expected from general hydrodynamic reasoning, we find that both of these quantities are diffusive over distance and time scales larger than the inverse temperature. We compute the diffusion constants and conductivities of transverse momentum and charge, as well the ratio of shear viscosity to entropy density, and find that they differ from their relativistic counterparts. To derive these results, we propose how the holographic dictionary should be modified to deal with the multiple horizons and differing propagation speeds of bulk excitations in Hořava gravity. When possible, as a check on our methods and results, we use the covariant Einstein-Aether formulation of Hořava gravity, along with field redefinitions, to re-derive our results from a relativistic bulk theory.

  2. Koncepce tlačítkového piezo-generátoru

    OpenAIRE

    Kučera, David

    2012-01-01

    Tato bakalářská práce se zabývá koncepcí tlačítkového piezo-generátoru. V práci jsou popsány typy piezo-generátorů, vysvětlen piezoelektrický jev, typy piezoelektrických materiálů se zaměřením na piezokeramiku. Dále jsou popsány materiálové vlastnosti piezoelektrických keramik. Na konci práce je popsán návrh samotného tlačítkového piezo-generátoru. This bachelor’s thesis deals with proposal of piezo-generator inside button. There are described types of piezo-generators, explained piezoelec...

  3. CA V is present in rat kidney mitochondria

    International Nuclear Information System (INIS)

    Dodgson, S.J.; Contino, L.C.

    1987-01-01

    Guinea pig liver mitochondria contain the unique carbonic anhydrase isozyme, CA V. Prior to sacrifice, 15 rats and 15 guinea pigs were either fed normal lab chow (group 1), starved 48 hours (group 2) or fed normal lab chow and given to drink only water with added HCl, pH 2.5 (group 3). Mitochondria were prepared from excised livers and kidneys. CA V activity of disrupted mitochondria was measured by 18 O-mass spectrometric technique at pH 7.4, 37 0 C, 25 mM NaHCO 3 . Mass spectrometric CA assays with intact kidney mitochondria localize CA V activity to the matrix, as was found for liver mitochondria. It has been shown in hepatocytes prepared from starved guinea pigs and rats that inhibition of CA V results in decreased rate of gluconeogenesis from pyruvate. These present results are in line with the published observation that rat kidneys are much more gluconeogenic than guinea pig, and that this is increased by starvation and acidosis

  4. Zvýšení ročního využití parního práškového kotle K5 ve ŽĎAS, a. s

    OpenAIRE

    Kubiš, David

    2017-01-01

    Tato diplomová práce se zabývá vyšším využitím kotle K5 v teplárně ŽĎAS, a.s. v přechodném období, kdy vlivem snížených odběrů dochází k přehřívání zpáteční větve horkovodu a je nutnost přejíždět na jiný kotel. Cílem práce je omezit přejíždění z kotle K5 na kotel K3 a zvýšit jeho časové využití v přechodném období pomocí ekonomicky únosného technického řešení. Na začátku práce je popsána teplárna ŽĎAS, a.s. a její vybavení. Následují čtyři metody výpočtů zvýšení ročního využití kotle K5. A to...

  5. Single crystal polarized neutron diffraction study of the magnetic structure of HoFeO3.

    Science.gov (United States)

    Chatterji, T; Stunault, A; Brown, P J

    2017-09-27

    Polarised neutron diffraction measurements have been made on HoFeO 3 single crystals magnetised in both the [0 0 1] and [1 0 0] directions (Pbnm setting). The polarisation dependencies of Bragg reflection intensities were measured both with a high field of [Formula: see text] T parallel to [0 0 1] at [Formula: see text] K and with the lower field [Formula: see text] T parallel to [1 0 0] at [Formula: see text] K. A Fourier projection of magnetization induced parallel to [0 0 1], made using the hk0 reflections measured in 9 T, indicates that almost all of it is due to alignment of Ho moments. Further analysis of the asymmetries of general reflections in these data showed that although, at 70 K, 9 T applied parallel to [0 0 1] hardly perturbs the antiferromagnetic order of the Fe sublattices, it induces significant antiferromagnetic order of the Ho sublattices in the [Formula: see text] plane, with the antiferromagnetic components of moment having the same order of magnitude as the induced ferromagnetic ones. Strong intensity asymmetries measured in the low temperature [Formula: see text] structure with a lower field, 0.5 T [Formula: see text] [1 0 0] allowed the variation of the ordered components of the Ho and Fe moments to be followed. Their absolute orientations, in the [Formula: see text] domain stabilised by the field were determined relative to the distorted perovskite structure. This relationship fixes the sign of the Dzyalshinski-Moriya (D-M) interaction which leads to the weak ferromagnetism. Our results indicate that the combination of strong y-axis anisotropy of the Ho moments and Ho-Fe exchange interactions breaks the centrosymmetry of the structure and could lead to ferroelectric polarization.

  6. A comparative study on Ca content and distribution in two Gesneriaceae species reveals distinctive mechanisms to cope with high rhizospheric soluble calcium

    Directory of Open Access Journals (Sweden)

    Wenlong eLi

    2014-11-01

    Full Text Available Excessive Ca is toxic to plants thus significantly affects plant growth and species distribution in Ca-rich karst areas. To understand how plants survive high Ca soil, laboratory experiments were established to compare the physiological responses and internal Ca distribution in organ, tissue, cell and intracellular levels under different Ca levels for Lysionotus pauciflorus and Boea hygrometrica, two karst habitant Gesneriaceae species in Southwest China. In the controlled condition, L. pauciflorus could survive as high as 200 mM rhizospheric soluble Ca, attributed to a series of physiological responses and preferential storage that limited Ca accumulation in chloroplasts of palisade cells. In contrast, B. hygrometrica could survive only 20 mM rhizospheric soluble Ca, but accumulated a high level of internal Ca in both palisade and spongy cells without disturbance on photosynthetic activity. By phenotype screening of transgenic plants expressing high Ca-inducible genes from B. hygrometrica, the expression of BhDNAJC2 in A. thaliana was found to enhance plant growth and photosynthesis under high soluble Ca stress. BhDNAJC2 encodes a recently reported heat shock protein (HSP 40 family DnaJ-domain protein. The Ca-resistant phenotype of BhDNAJC2 highlights the important role of chaperone-mediated protein quality control in Ca tolerance in B. hygrometrica. Taken together, our results revealed that distinctive mechanisms were employed in the two Gesneriaceae karst habitants to cope with a high Ca environment.

  7. Heme oxygenase-1 (HO-1 expression in prostate cancer cells modulates the oxidative response in bone cells.

    Directory of Open Access Journals (Sweden)

    Mercedes Ferrando

    Full Text Available Prostate cancer (PCa is a leading cause of death among males. It is currently estimated that inflammatory responses are linked to 15-20% of all deaths from cancer worldwide. PCa is dominated by complications arising from metastasis to the bone where the tumor cells interact with the bone microenvironment impairing the balance between bone formation and degradation. However, the molecular nature of this interaction is not completely understood. Heme oxygenase-1 (HO-1 counteracts oxidative damage and inflammation. Previous studies from our laboratory showed that HO-1 is implicated in PCa, demonstrating that endogenous HO-1 inhibits bone derived-prostate cancer cells proliferation, invasion and migration and decreases tumor growth and angiogenesis in vivo. The aim of this work was to analyze the impact of HO-1 modulated PCa cells on osteoblasts proliferation in vitro and on bone remodeling in vivo. Using a co-culture system of PC3 cells with primary mice osteoblasts (PMOs, we demonstrated that HO-1 pharmacological induction (hemin treatment abrogated the diminution of PMOs proliferation induced by PCa cells and decreased the expression of osteoclast-modulating factors in osteoblasts. No changes were detected in the expression of genes involved in osteoblasts differentiation. However, co-culture of hemin pre-treated PC3 cells (PC3 Hem with PMOs provoked an oxidative status and activated FoxO signaling in osteoblasts. The percentage of active osteoblasts positive for HO-1 increased in calvarias explants co-cultured with PC3 Hem cells. Nuclear HO-1 expression was detected in tumors generated by in vivo bone injection of HO-1 stable transfected PC3 (PC3HO-1 cells in the femur of SCID mice. These results suggest that HO-1 has the potential to modify the bone microenvironment impacting on PCa bone metastasis.

  8. A comparable study of clinical and optical outcomes after 1.8, 2.0 mm microcoaxial and 3.0 mm coaxial cataract surgery.

    Science.gov (United States)

    Yu, Yi-Bo; Zhu, Ya-Nan; Wang, Wei; Zhang, Yi-Dong; Yu, Yin-Hui; Yao, Ke

    2016-01-01

    To evaluate the clinical and optical outcomes after clear corneal incision cataract surgery (CICS) with three different incision sizes (1.8, 2.0 and 3.0 mm). Eyes of 150 patients with age-related cataract scheduled for coaxial cataract surgery were randomized to three groups: 1.8, 2.0, or 3.0 mm CICS. Intraoperative data and postoperative outcomes including surgically induced astigmatism (SIA), the corneal incision thickness, wavefront aberrations and modulation transfer function (MTF) of cornea were obtained. There were no significant differences among the three groups in demographic characteristics and intraoperative outcome. The 1.8 and 2.0 mm microincisions showed more satisfactory clinical outcomes than the 3.0 mm incision. The 1.8 mm incision showed significantly less SIA than the 2.0 mm incision until postoperative 1mo (P0.05). Converting from 3.0 mm CICS to 1.8 or 2.0 mm CICS result in better clinical and optical outcomes. However, when incision is 1.8 mm, the benefits from further reduction in size compared with 2.0 mm are limited. The necessity to reduce the incision size is to be deliberated.

  9. Hořava Gravity is Asymptotically Free in 2+1 Dimensions.

    Science.gov (United States)

    Barvinsky, Andrei O; Blas, Diego; Herrero-Valea, Mario; Sibiryakov, Sergey M; Steinwachs, Christian F

    2017-11-24

    We compute the β functions of marginal couplings in projectable Hořava gravity in 2+1 spacetime dimensions. We show that the renormalization group flow has an asymptotically free fixed point in the ultraviolet (UV), establishing the theory as a UV-complete model with dynamical gravitational degrees of freedom. Therefore, this theory may serve as a toy model to study fundamental aspects of quantum gravity. Our results represent a step forward towards understanding the UV properties of realistic versions of Hořava gravity.

  10. Cosmological perturbations in the projectable version of Hořava-Lifshitz gravity

    International Nuclear Information System (INIS)

    Cerioni, Alessandro; Brandenberger, Robert H.

    2011-01-01

    We consider linear perturbations about a homogeneous and isotropic cosmological background in the projectable version of Hořava-Lifshitz gravity. Starting from the action for cosmological perturbations, we identify the canonically normalized fluctuation variables. We find that - in contrast to what happens in the non-projectable version of the theory - the extra scalar cosmological perturbation mode is already dynamical at the level of linear perturbations and is either ghost-like or tachyonic depending on the value of a free parameter. This indicates a problem for the projectable version of Hořava-Lifshitz gravity

  11. {sup 166} Ho-EDTMP in detecting bone metastases: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Achando, S.S.; Fernandes, L.; Herrerias, R.; Muramoto, E.; Almeida, M.A.T.; Pereira, N.S. de; Mengatti, J. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)

    1995-12-31

    Holmium-166-EDTMP (ethylene-dimine-tetra methylene phosphonic acid) due to its promising biological properties, has proved to be a palliating therapeutic agent for bone cancer in human beings. In a basic medium, {sup 166} Ho-EDTMP can be readily prepared with a complexing molar ratio EDTMP/Ho 4.34. The radiochemical purity of the complex was higher than 98%. The biodistribution in rats and mice, showed a high skeletal uptake, a fast blood clearance and a low soft tissue uptake and a lesion to normal bone ratio equal to 2. (author). 3 refs., 4 tabs.

  12. Magnetic and Moessbauer studies of amorphous Fe72-xYxHo8B20 alloys

    International Nuclear Information System (INIS)

    Krishnan, R.; Dumond, Y.; Ajan, A.; Shringi, S.N.; Prasad, S.

    1996-01-01

    We have carried out magnetic and Moessbauer studies of amorphous Fe 72-x Y x Ho 8 B 20 alloys. The Fe moment decreases with the addition of Y and a magnetic compensation occurs at 4 K for x=16. The temperature and field dependences of the magnetization have been interpreted using the mean field theory and Chudnovsky's model, respectively. These analyses yield some interesting parameters such as the random anisotropy, the exchange interactions J Fe-Fe , J Fe-Ho , etc. The Moessbauer studies show that the average hyperfine field decreases linearly with the addition of Y, in accordance with the decrease in the Fe moment. (orig.)

  13. Preparation, characterization and luminescence of nanocrystalline Y2O3:Ho

    International Nuclear Information System (INIS)

    Biljan, Tomislav; Gajovic, Andreja; Meic, Zlatko; Mestrovic, Ernest

    2007-01-01

    Nanocrystalline Y 2 O 3 :Ho was synthesized by solution combustion method with ethylene glycol as fuel. Material was characterized using powder X-ray diffraction and transmission electron microscopy (TEM). X-ray diffraction and TEM showed that the material is nanostructured. Luminescence properties were studied using Raman spectrometers with excitation in near infrared (NIR) and visible regions. The visible and NIR luminescence spectra of nanocrystalline Y 2 O 3 :Ho show some important differences from those of bulk material. The convenience of using Raman instruments for studying luminescence of lanthanide ions is demonstrated

  14. Radiolytic oxidation of tamoxifen using the free radicals .OH and (or) HO2

    International Nuclear Information System (INIS)

    Leguene, C.; Clavere, P.; Jore, D.; Gardes-Albert, M.

    2001-01-01

    Tamoxifen is the most widely used antiestrogen in the treatment of breast cancer. In this work, we have studied its antioxidant properties. We have investigated the ability of tamoxifen to scavenge, in vitro, . OH and (or) HO 2 . free radicals that are produced by water radiolysis. Aqueous solutions of tamoxifen of concentrations ranging between 10 -5 and 2.5 x 10 -5 M have been irradiated (γ 137 Cs) in aerated acidic medium (H 3 PO 4 10 -3 M or HCOOH 10 -1 M). The results show that tamoxifen reacts quantitatively with . OH free radicals but does not react with HO 2 . free radicals under our experimental conditions. (author)

  15. Knudsen cell vaporization of rare earth nitrides: enthalpy of vaporization of HoN098

    International Nuclear Information System (INIS)

    Brown, R.C.; Clark, N.J.

    1975-01-01

    The enthalpy of vaporization of HoN 0 . 98 was measured by the weight-loss Knudsen cell technique using Motzfeldt-Whitman extrapolations to zero orifice area. A third-law enthalpy of vaporization of HoN 0 . 98 of 155.9 +- 5 kcal mole -1 was obtained compared to a second-law value of 162.0 +- 5 kcal mole -1 . Similar measurements on the nitrides of samarium, erbium, and ytterbium gave third-law enthalpies of vaporization of 126.8 +-- 5 kcal mole -1 ; 159.6 +- 5 kcal mole -1 , and 121.0 +- 5 kcal mole -1 , respectively. 7 tables

  16. MASJID JAMI PITI LAKSAMANA MUHAMMAD CHENG HO PURBALINGGA: SIMBOL KEINDAHAN TOLERANSI DALAM AKULTURASI

    Directory of Open Access Journals (Sweden)

    Dinda Wulan Afriani

    2015-10-01

    terletak di Kabupaten Purbalingga, Jawa Tengah. Masjid Laksamana Muhammad Cheng Ho Purbalingga merupakan salah satu dari tiga masjid Cheng Ho di Indonesia. Kehadiran masjid ini merupakan wujud simbol keindahan toleransi antar etnis dan budaya dalam sebuah akulturasi. Bentuk arsitektur masjid ini merupakan perpaduan dari budaya Islam- Tiongkok-Arab-Jawa. Keistimewaan masjid ini bukan hanya terletak pada bentuk arsitektur bangunan dan ragam hias arsitekturnya saja. Namun juga pada keindahan makna dan nilai falsafah kehidupan yang terkandung di dalamnya, yang tentu saja selaras dengan peran sertanya dalam masyarakat. Dalam membaca tanda dan makna, artikel ini juga menyajikan penalaran melalui metode semiotika visual secara singkat namun cukup padat.

  17. Electronic absorption bands of HoCl3 and SmCl3 complexes in alcohols

    International Nuclear Information System (INIS)

    Ramesh Babu, V.; Buddhudu, S.; Rangarajan, V.N.

    1987-01-01

    The normal absorption and second derivative spectra of ten alcoholic complexes of HoCl 3 and SmCl 3 were recorded. From the observed bands, energies and intensity values were measured. To fit in these measured values with the theoretical values, a set of spectroscopic parameters namely, Judd-Ofelt (T 2 , T 4 , T 6 ), intensity (Ω 2 , Ω 4 , Ω 6 ) had been computed. A good fit of intensities was obtained between the experimental and theoretical data. The environmental influences on the intensities of the hypersensitive transitions of Sm(III) and Ho(III) ions were found to be noteworthy. (author). 7 tables, 20 refs

  18. Magnetic properties of a HoCo10Ti2 single crystal

    International Nuclear Information System (INIS)

    Janssen, Y.; Tegus, O.; Klaasse, J.C.P.; Brueck, E.; Buschow, K.H.J.; Boer, F.R. de

    2001-01-01

    The magnetic properties of single-crystalline easy-axis ThMn 12 -type ferrimagnetic HoCo 10 Ti 2 have been studied. At 4.2 K, the magnetization process with the field applied along the easy c-axis is completely different from that, with the field applied perpendicular to it. The bending process of the initially antiparallel Ho and Co magnetic moments, that is observed in the latter measurement, is briefly described in terms of mean-field theory. Furthermore, when the field is applied in the hard magnetization direction, the bending process has directly been observed by means of measurement of the transversal magnetization

  19. Extracellular Ca(2+)-dependent enhancement of cytocidal potency of zoledronic acid in human oral cancer cells.

    Science.gov (United States)

    Inoue, Sayaka; Arai, Naoya; Tomihara, Kei; Takashina, Michinori; Hattori, Yuichi; Noguchi, Makoto

    2015-08-15

    Direct antitumor effects of bisphosphonates (BPs) have been demonstrated in various cancer cells in vitro. However, the effective concentrations of BPs are typically much higher than their clinically relevant concentrations. Oral cancers frequently invade jawbone and may lead to the release of Ca(2+) in primary lesions. We investigated the effects of the combined application of zoledronic acid (ZA) and Ca(2+) on proliferation and apoptosis of oral cancer cells. Human oral cancer cells, breast cancer cells, and colon cancer cells were treated with ZA at a wide range of concentrations in different Ca(2+) concentration environments. Under a standard Ca(2+) concentration (0.6mM), micromolar concentrations of ZA were required to inhibit oral cancer cell proliferation. Increasing extracellular Ca(2+) concentrations greatly enhanced the potency of the ZA cytocidal effect. The ability of Ca(2+) to enhance the cytocidal effects of ZA was negated by the Ca(2+)-selective chelator EGTA. In contrast, the cytocidal effect of ZA was less pronounced in breast and colon cancer cells regardless of whether extracellular Ca(2+) was elevated. In oral cancer cells incubated with 1.6mM Ca(2+), ZA up-regulated mitochondrial Bax expression and increased mitochondrial Ca(2+) uptake. This was associated with decreased mitochondrial membrane potential and increased release of cytochrome c. We suggest that ZA can specifically produce potent cytocidal activity in oral cancer cells in an extracellular Ca(2+)-dependent manner, implying that BPs may be useful for treatment of oral squamous cell carcinoma with jawbone invasion leading to the hypercalcemic state. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. Automatická segmentace periodického pohybu srdečního svalstva v EKG záznamu

    OpenAIRE

    Matocha, Petr

    2015-01-01

    Tato práce se zabývá automatickou segmentací periodického pohybu srdečního svalstva v EKG záznamu. Popisuje návrh a implementaci aplikace, jenž automaticky segmentuje EKG záznam na jednotlivé srdeční stahy. EKG záznam je uložen samostatně nebo je součástí videozáznamu. Tyto vstupní data jsou uložena v souborech ve formátu HDF nebo DICOM. This thesis deals with the automatic segmentation of the cardiac tissue movement from ECG record. It describes the design and implementation of applicatio...

  1. Defective Ca2+ metabolism in Duchenne muscular dystrophy: effects on cellular and viral growth.

    OpenAIRE

    Fingerman, E; Campisi, J; Pardee, A B

    1984-01-01

    Normal fibroblasts in medium containing 0.02 mM CaCl2 arrested growth within 24 hr, whereas Duchenne muscular dystrophy fibroblasts continued to grow for 5 days, albeit at 40% of their rate in standard medium (1.8 mM CaCl2). Moreover, Duchenne cells in calcium-deficient medium showed an enhanced rate of protein synthesis (60% over the rate in standard medium), whereas normal cells were unaffected. Previously we described a general assay for detection of mutant cells by using herpes simplex vi...

  2. Calculus migration characterization during Ho:YAG laser lithotripsy by high-speed camera using suspended pendulum method.

    Science.gov (United States)

    Zhang, Jian James; Rajabhandharaks, Danop; Xuan, Jason Rongwei; Chia, Ray W J; Hasenberg, Thomas

    2017-07-01

    Calculus migration is a common problem during ureteroscopic laser lithotripsy procedure to treat urolithiasis. A conventional experimental method to characterize calculus migration utilized a hosting container (e.g., a "V" grove or a test tube). These methods, however, demonstrated large variation and poor detectability, possibly attributed to the friction between the calculus and the container on which the calculus was situated. In this study, calculus migration was investigated using a pendulum model suspended underwater to eliminate the aforementioned friction. A high-speed camera was used to study the movement of the calculus which covered zero order (displacement), first order (speed), and second order (acceleration). A commercialized, pulsed Ho:YAG laser at 2.1 μm, a 365-μm core diameter fiber, and a calculus phantom (Plaster of Paris, 10 × 10 × 10 mm 3 ) was utilized to mimic laser lithotripsy procedure. The phantom was hung on a stainless steel bar and irradiated by the laser at 0.5, 1.0, and 1.5 J energy per pulse at 10 Hz for 1 s (i.e., 5, 10, and 15 W). Movement of the phantom was recorded by a high-speed camera with a frame rate of 10,000 FPS. The video data files are analyzed by MATLAB program by processing each image frame and obtaining position data of the calculus. With a sample size of 10, the maximum displacement was 1.25 ± 0.10, 3.01 ± 0.52, and 4.37 ± 0.58 mm for 0.5, 1, and 1.5 J energy per pulse, respectively. Using the same laser power, the conventional method showed <0.5 mm total displacement. When reducing the phantom size to 5 × 5 × 5 mm 3 (one eighth in volume), the displacement was very inconsistent. The results suggested that using the pendulum model to eliminate the friction improved sensitivity and repeatability of the experiment. A detailed investigation on calculus movement and other causes of experimental variation will be conducted as a future study.

  3. Synthesis and release of luteinizing hormone in vitro: manipulations of Ca2+ environment

    International Nuclear Information System (INIS)

    Liu, T.C.; Jackson, G.L.

    1985-01-01

    The authors determined if luteinizing hormone (LH) synthesis is Ca2+ dependent and coupled to LH release. They monitored LH synthesis when LH release was stimulated either by specific [gonadotropin-releasing hormone (GnRH)] or nonspecific stimuli (50 mM K+ and 2 or 20 microM Ca2+ ionophore A23187) and inhibited by Ca2+-reduced medium. LH synthesis was estimated by measuring incorporation of [ 3 H]glucosamine (glycosylation) and [ 14 C]alanine (translation) into total (cell and medium) immunoprecipitable LH by cultured rat anterior pituitary cells. Both GnRH (1 nM) and 50 mM K+ significantly stimulated LH release and glycosylation, but had no effect on LH translation. A23187 also stimulated LH release, but significantly depressed glycosylation of LH and total protein and [ 14 C]alanine uptake. Deletion of Ca2+ from the medium depressed both GnRH-induced LH release and glycosylation. Addition of 0.1 mM EGTA to Ca2+-free medium not only inhibited GnRH-induced release and glycosylation of LH but also uptake of precursors and glycosylation and translation of total protein. Thus, glycosylation and release of LH are Ca2+ dependent. Whether parallel changes in LH release and glycosylation reflect a cause and effect relationship remains to be determined

  4. Effect of 1,25(OH)2 vitamin D3 and ionized Ca2+ on 45Ca uptake by primary cultures of aortic myocytes of spontaneously hypertensive and Wistar Kyoto normotensive rats

    International Nuclear Information System (INIS)

    Bukoski, R.D.; Xue, H.; McCarron, D.A.

    1987-01-01

    The effect of several regulators of whole animal Ca 2+ homeostasis on 45 Ca uptake by primary cultures of aortic myocytes isolated from spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats was examined. Exposure of confluent cells to 1.0, 1.25 or 1.50 mM ionized Ca 2+ in serum-free medium for seven days resulted in increased 45 Ca uptake at the higher concentrations of Ca 2+ in cells of the SHR but not the WKY. 1,25 (OH)2 vitamin D3 (1 ng/ml) for 7 days caused enhanced influx in cells from both the SHR and WKY while parathyroid hormone (1-34) (1 ng/ml) was without effect. The data indicate that humoral factors that serve to regulate whole animal Ca 2+ homeostasis may also play a role in the regulation of Ca 2+ metabolism of the vascular smooth muscle cell

  5. The HoMBReS and HoMBReS Por un Cambio Interventions to Reduce HIV Disparities Among Immigrant Hispanic/Latino Men.

    Science.gov (United States)

    Rhodes, Scott D; Leichliter, Jami S; Sun, Christina J; Bloom, Fred R

    2016-02-12

    Hispanics/Latinos in the United States are affected disproportionately by human immunodeficiency virus (HIV) infection, acquired immunodeficiency syndrome (AIDS), and other sexually transmitted diseases (STDs); however, few effective evidence-based prevention interventions for this population exist. This report describes the Hombres Manteniendo Bienestar y Relaciones Saludables (Men Maintaining Wellbeing and Healthy Relationships) (HoMBReS) intervention, which was developed by a community-based, participatory research partnership in North Carolina and initially implemented during 2005-2009. HoMBReS is an example of an effective intervention that uses lay health advisors (known as Navegantes [navigators]) in the context of existing social networks (i.e., recreational soccer teams) to promote consistent condom use and HIV and STD testing among Hispanic/Latino men. In 2012, HoMBReS was classified as a best-evidence community-level HIV prevention intervention (CDC. Compendium of evidence-based behavioral interventions and best practices for HIV prevention. Atlanta, GA: US Department of Health and Human Services, CDC; 2015). The intervention has been implemented elsewhere, enhanced, and further evaluated in longitudinal intervention and implementation studies. HoMBReS has been adapted for other populations, including men who have sex with men and transgender persons. Additional evaluation has found that Navegantes continue in their roles as health advisors, opinion leaders, and community advocates after study support ends. Hispanic/Latino men's social networks can be leveraged to promote sexual health within the community by decreasing HIV risk behaviors among Hispanics/Latinos in the United States.

  6. The HoMBReS and HoMBReS Por un Cambio Interventions to Reduce HIV Disparities Among Immigrant Hispanic/Latino Men

    OpenAIRE

    Rhodes, Scott D.; Leichliter, Jami S.; Sun, Christina J.; Bloom, Fred R.

    2016-01-01

    Hispanics/Latinos in the United States are affected disproportionately by human immunodeficiency virus (HIV) infection, acquired immunodeficiency syndrome (AIDS), and other sexually transmitted diseases (STDs); however, few effective evidence-based prevention interventions for this population exist. This report describes the Hombres Manteniendo Bienestar y Relaciones Saludables (Men Maintaining Wellbeing and Healthy Relationships) (HoMBReS) intervention, which was developed by a community-bas...

  7. TRAPPING HO2 FREE RADICAL IN SONICATED WATER%空化水中HO2自由基的捕获

    Institute of Scientific and Technical Information of China (English)

    刘岩; 王军

    2003-01-01

    @@ 1 INTRODUCTION As a new advanced oxidation process (AOP) in water treatment, sonochemistry in water treatment has been paid more attention for one decade[1-7]. The collapsed cavitation bubbles give rise to high temperature and high pressure[8] to generate free radical, e.g. OH, O, HO2 in sonicated water. These kinds of radicals can oxidize the organic substances dissolved in water.

  8. Mobilisation of store Ca2+ activates tyrosine hydroxylase in bovine adrenal chromaffin cells

    International Nuclear Information System (INIS)

    McKenzie, S.; Marley, P.D.

    2001-01-01

    Full text: Many receptor agonists are able to activate tyrosine hydroxylase (TOH) in bovine adrenal chromaffin cells. The majority of these are dependent on extracellular Ca 2+ for this action. Entry of extracellular Ca 2+ through voltage-operated Ca 2+ channels is very effective at activating TOH. The contribution of the intracellular Ca 2+ stores to TOH activation however is not known. Previous studies have shown that mobilisation of intracellular Ca 2+ stores is effective at increasing phosphorylation of TOH, but its effect on TOH activity has not been studied. Therefore, in the present study, the effect of mobilisation of store Ca 2+ on TOH activity was investigated using primary cultures of bovine adrenal chromaffin cells. Cells were prepared from abattoir tissue and cultured for 3-6 days. TOH activity was determined over 10 minutes, measuring the 14 CO 2 produced following the hydroxylation and rapid decarboxylation of 14 C-tyrosine offered to intact cells. Caffeine increased TOH activity in a concentration-dependent manner with a maximum response of 100% increase at 20mM. This effect was not due to osmolarity since 20mM sucrose had no effect.Nor was it due to inhibition of phosphodiesterases, since the effect of caffeine was still seen in the presence of 1mM IBMX. However,caffeine-induced TOH activation was substantially reduced in the absence of extracellular Ca 2+ . The results suggest that TOH activity can be increased by mobilising intracellular Ca 2+ stores, but that this effect involves extracellular Ca 2+ influx, possibly through store-operated channels. Copyright (2001) Australian Neuroscience Society

  9. Study and application of neutron activation analysis and related methods for determination of content of Na, K, Cu, Co, Mn, Ca, Mg, Fe, P and Zn in a lot of speciality fruits of Vietnam (banana, orange, longan, dragon and mango)

    International Nuclear Information System (INIS)

    Nguyen Van Minh; Le Thi Ngoc Trinh; Le Thai Dung; Ta Thi Tuyet Nhung; Nguyen Dang Khoa; Nguyen Tien Dat; Nguyen Thi Hong Tham; Cao Dong Vu

    2007-01-01

    To study the content of trace elements Na, K, Cu, Co, Mn, Ca, Mg, Fe, P and Zn in the speciality fruits is necessary and very important. We collected the studying samples in four Cities such as: Dalat, NhaTrang, HoChiMinh and BinhDuong. The studying samples are: Banana, Orange, Longan, Dragon and Mango. These samples were dried in the Deepfreezer at -40 o C. We analyzed Na, K, Cu, Co, Mn, Ca, Mg, Fe and Zn by neutron activation analysis (INAA, RNAA) and after irradiation measured total β for P. The studying results were shown in the tables. (author)

  10. Study and application of neutron activation analysis and related methods for determination of content of Na, K, Cu, Co, Mn, Ca, Mg, Fe, P and Zn in a lot of speciality fruits of Vietnam (banana, orange, longan, dragon and mango)

    Energy Technology Data Exchange (ETDEWEB)

    Minh, Nguyen Van; Ngoc Trinh, Le Thi; Dung, Le Thai; Tuyet Nhung, Ta Thi; Khoa, Nguyen Dang; Dat, Nguyen Tien; Hong Tham, Nguyen Thi; Vu, Cao Dong [Center for Analytical Techniques, Nuclear Research Institute, Dalat (Viet Nam)

    2007-12-15

    To study the content of trace elements Na, K, Cu, Co, Mn, Ca, Mg, Fe, P and Zn in the speciality fruits is necessary and very important. We collected the studying samples in four Cities such as: Dalat, NhaTrang, HoChiMinh and BinhDuong. The studying samples are: Banana, Orange, Longan, Dragon and Mango. These samples were dried in the Deepfreezer at -40{sup o}C. We analyzed Na, K, Cu, Co, Mn, Ca, Mg, Fe and Zn by neutron activation analysis (INAA, RNAA) and after irradiation measured total {beta} for P. The studying results were shown in the tables. (author)

  11. Expression and characterization of truncated human heme oxygenase (hHO-1) and a fusion protein of hHO-1 with human cytochrome P450 reductase.

    Science.gov (United States)

    Wilks, A; Black, S M; Miller, W L; Ortiz de Montellano, P R

    1995-04-04

    A human heme oxygenase (hHO-1) gene without the sequence coding for the last 23 amino acids has been expressed in Escherichia coli behind the pho A promoter. The truncated enzyme is obtained in high yields as a soluble, catalytically-active protein, making it available for the first time for detailed mechanistic studies. The purified, truncated hHO-1/heme complex is spectroscopically indistinguishable from that of the rat enzyme and converts heme to biliverdin when reconstituted with rat liver cytochrome P450 reductase. A self-sufficient heme oxygenase system has been obtained by fusing the truncated hHO-1 gene to the gene for human cytochrome P450 reductase without the sequence coding for the 20 amino acid membrane binding domain. Expression of the fusion protein in pCWori+ yields a protein that only requires NADPH for catalytic turnover. The failure of exogenous cytochrome P450 reductase to stimulate turnover and the insensitivity of the catalytic rate toward changes in ionic strength establish that electrons are transferred intramolecularly between the reductase and heme oxygenase domains of the fusion protein. The Vmax for the fusion protein is 2.5 times higher than that for the reconstituted system. Therefore, either the covalent tether does not interfere with normal docking and electron transfer between the flavin and heme domains or alternative but equally efficient electron transfer pathways are available that do not require specific docking.

  12. CaWingz user's guide

    International Nuclear Information System (INIS)

    Cha, Ben-chin.

    1994-01-01

    This document assumes that you have read and understood the Wingz user's manuals. CaWingz is an external Wingz program which, when combined with a set of script files, provides easy-to-use EPICS channel access interface functions for Wingz users. The external function run allows Wingz user to invoke any Unix processor within caWingz. Few additional functions for accessing static database field and monitoring of value change event is available for EPICS users after release 3.11. The functions, script files, and usage are briefly described in this document. The script files supplied here serve as examples only. Users are responsible for generating their own spreadsheet and script files. CaWingz communicates with IOC through channel access function calls

  13. Odhad možných následků při úniku hořlavé látky

    OpenAIRE

    Miček, Michal

    2013-01-01

    Táto bakalárska práca bola zameraná na odhad možných následkov pri úniku horľavej látky. Práca je rozdelená do troch hlavných časti. V prvej časti sú obsiahnuté vybrané závažné priemyselné havárie vo svete aj v Českej Republike a niektoré pojmy spojené s následkami pri úniku horľavej látky. Druhá časť obsahuje stručný popis použitého programu (ALOHA 5.4.3) spolu s charakteristikou niektorých vstupných parametrov pre modelované typové havárie – požiar typu Jet Fire zo zariadení používaných pre...

  14. Methylglyoxal and other carbohydrate metabolites induce lanthanum-sensitive Ca2+ transients and inhibit growth in E. coli.

    Science.gov (United States)

    Campbell, Anthony K; Naseem, Riffat; Holland, I Barry; Matthews, Stephanie B; Wann, Kenneth T

    2007-12-01

    The results here are the first demonstration of a family of carbohydrate fermentation products opening Ca2+ channels in bacteria. Methylglyoxal, acetoin (acetyl methyl carbinol), diacetyl (2,3 butane dione), and butane 2,3 diol induced Ca2+ transients in Escherichia coli, monitored by aequorin, apparently by opening Ca2+ channels. Methylglyoxal was most potent (K(1/2) = 1 mM, 50 mM for butane 2,3 diol). Ca2+ transients depended on external Ca2+ (0.1-10 mM), and were blocked by La3+ (5 mM). The metabolites affected growth, methylglyoxal being most potent, blocking growth completely up to 5 h without killing the cells. But there was no affect on the number of viable cells after 24 h. These results were consistent with carbohydrate products activating a La3+-sensitive Ca2+ channel, rises in cytosolic Ca2+ possibly protecting against certain toxins. They have important implications in bacterial-host cell signalling, and where numbers of different bacteria compete for the same substrates, e.g., the gut in lactose and food intolerance.

  15. Neutron depolarization measurements of HoCo2 near the magnetic phase transition

    International Nuclear Information System (INIS)

    Kraan, W.

    1976-09-01

    The magnetic phase transition in HoCo 2 at zero applied field is investigated. The Landau theory of magnetic phase transition is discussed. The experimental technique for neutron depolarization measurements in the temperature range 65-90 K is described

  16. Návrh podnikatelského záměru

    OpenAIRE

    Lanc, Martin

    2009-01-01

    Cílem této diplomové práce je definovat podnikatelský záměr konkrétního malého podniku a následně ho zpracovat do podoby podnikatelského plánu. Tento záměr bude sloužit jako podklad pro realizaci soukromé mateřské školy. Diplomová práce obsahuje teoretickou část, analýzu problému včetně zákonných podmínek zřízení a provozu firmy, konečně i marketingové analýzy a finanční plán. Závěr práce se věnuje celkovému shrnutí výsledků a možnostech rozvoje. The subject diploma thesis “Proposal for a ...

  17. Diode-pumped efficient laser operation and spectroscopy of Tm,Ho:YVO 4

    Science.gov (United States)

    Li, G.; Yao, B. Q.; Meng, P. B.; Duan, X. M.; Ju, Y. L.; Wang, Y. Z.

    2011-04-01

    Spectroscopic characterization of co-doped Tm,Ho:YVO 4 crystal grown by the Czochralski method has been performed including absorption spectrum, emitting spectrum and luminescence decay lifetime. The polarization emitting spectrum around 2 μm is accomplished by exciting a singly Ho 3+ doped YVO 4 crystal to exclude the influence of Tm 3+3F 4- 3H 6 transition and the emission cross section is deduced from both Fuchtbauer-Ladenburg (F-L) equation and reciprocity method (RM). In addition, we report up to 10.4 W continuous wave (CW) output with a conversion efficiency of 40% and 10.3 W Q-Switch output with 12.5 kHz pulse repetition rate of diode-pumped cryogenic Tm,Ho:YVO 4 laser. For Q-Switch operation, the minimum pulse width of 28.2 ns is obtained, all of which demonstrate that the Tm,Ho:YVO 4 is excellent laser material for 2 μm radiation.

  18. Radiochemical research and education program at the TU in Ho-Chi-Minh City

    International Nuclear Information System (INIS)

    Ngo Manh Thang

    2016-01-01

    In the first part of this presentation a review of studying programmes at the Ho-Chi-Minh City University of Technology as well as international co-operation is discussed. In the second part the results of gamma radiation induced radiolysis of sulfamethoxazole aqueous solutions are presented.

  19. Critical behavior of the magnetic susceptibility of the uniaxial ferromagnet LiHoF4

    DEFF Research Database (Denmark)

    Beauvillain, P.; Renard, J. P.; Laursen, Ib

    1978-01-01

    The magnetic susceptibility of two LiHoF4 single crystals has been measured in the range 1.2-4.2 K. Ferromagnetic order occurs at Tc=1.527 K. Above 2.5 K, the susceptibilities parallel and perpendicular to the fourfold c axis are well interpreted by the molecular-field approximation, taking...

  20. Three-dimensional magnetization process in HoFe.sub.11./sub.Ti

    Czech Academy of Sciences Publication Activity Database

    Janssen, Y.; Klaasse, J. C. P.; Brück, E.; De Boer, F. R.; Buschow, K. H. J.; Kamarád, Jiří; Kudrevatykh, N. V.

    2002-01-01

    Roč. 319, - (2002), s. 59-72 ISSN 0921-4526 Institutional research plan: CEZ:AV0Z1010914 Keywords : HoFe 11 Ti * magnetic anisotropy * magnetization processes * magnetization rotation * rare- earth -transition-metal compounds Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.609, year: 2002

  1. Preparation and Quality Control of 166Ho Labelled Polylactic Acid Microspheres for radiotherapy

    Czech Academy of Sciences Publication Activity Database

    Kropáček, Martin; Melichar, František; Klejzarová, Michaela; Ventruba, Jiří; Tomeš, Marek; Mirzajevová, Marcela

    2007-01-01

    Roč. 2, č. 332 (2007), s. 34-34 ISSN 1619-7070 R&D Projects: GA AV ČR 1QS100480501 Institutional research plan: CEZ:AV0Z10480505 Keywords : polylactic acid microspheres * 166Ho * liver tumour therapy Subject RIV: FR - Pharmacology ; Medidal Chemistry

  2. Edaravone Improves Septic Cardiac Function by Inducing an HIF-1α/HO-1 Pathway

    Directory of Open Access Journals (Sweden)

    Chao He

    2018-01-01

    Full Text Available Septic myocardial dysfunction remains prevalent and raises mortality rate in patients with sepsis. During sepsis, tissues undergo tremendous oxidative stress which contributes critically to organ dysfunction. Edaravone, a potent radical scavenger, has been proved beneficial in ischemic injuries involving hypoxia-inducible factor- (HIF- 1, a key regulator of a prominent antioxidative protein heme oxygenase- (HO- 1. However, its effect in septic myocardial dysfunction remains unclarified. We hypothesized that edaravone may prevent septic myocardial dysfunction by inducing the HIF-1/HO-1 pathway. Rats were subjected to cecal ligation and puncture (CLP with or without edaravone infusion at three doses (50, 100, or 200 mg/kg, resp. before CLP and intraperitoneal injection of the HIF-1α antagonist, ME (15 mg/kg, after CLP. After CLP, rats had cardiac dysfunction, which was associated with deformed myocardium, augmented lipid peroxidation, and increased myocardial apoptosis and inflammation, along with decreased activities of catalase, HIF-1α, and HO-1 in the myocardium. Edaravone pretreatment dose-dependently reversed the changes, of which high dose most effectively improved cardiac function and survival rate of septic rats. However, inhibition of HIF-1α by ME demolished the beneficial effects of edaravone at high dose, reducing the survival rate of the septic rats without treatments. Taken together, edaravone, by inducing the HIF-1α/HO-1 pathway, suppressed oxidative stress and protected the heart against septic myocardial injury and dysfunction.

  3. Radiosynoviorthesis of Knees by Means of 166Ho-Holmium-Boro-Macroaggregates

    Czech Academy of Sciences Publication Activity Database

    Kraft, O.; Kašpárek, R.; Ullmann, V.; Melichar, František; Kropáček, Martin; Mirzajevová, Marcela

    2007-01-01

    Roč. 22, č. 2 (2007), s. 296-302 ISSN 1084-9785 R&D Projects: GA AV ČR 1QS100480501 Institutional research plan: CEZ:AV0Z10480505 Keywords : radiosynoviorthesis * radionuclide synovectomy * 166Ho Subject RIV: FR - Pharmacology ; Medidal Chemistry Impact factor: 1.725, year: 2007

  4. Clinical presentation resembling mucosal disease associated with 'HoBi'-like pestivirus in a field outbreak

    Science.gov (United States)

    The genus Pestivirus of the family Flaviviridae consists of four recognized species: Bovine viral diarrhea virus 1 (BVDV-1), Bovine viral diarrhea virus 2 (BVDV-2), Classical swine fever virus (CSFV) And Border disease virus (BDV). Recently, atypical pestiviruses (‘HoBi’-like pestiviruses) were iden...

  5. Protectin DX suppresses hepatic gluconeogenesis through AMPK-HO-1-mediated inhibition of ER stress.

    Science.gov (United States)

    Jung, Tae Woo; Kim, Hyung-Chun; Abd El-Aty, A M; Jeong, Ji Hoon

    2017-06-01

    Several studies have shown that protectins, which are ω-3 fatty acid-derived proresolution mediators, may improve insulin resistance. Recently, protectin DX (PDX) was documented to attenuate insulin resistance by stimulating IL-6 expression in skeletal muscle, thereby regulating hepatic gluconeogenesis. These findings made us investigate the direct effects of PDX on hepatic glucose metabolism in the context of diabetes. In the current study, we show that PDX regulates hepatic gluconeogenesis in a manner distinct from its indirect glucoregulatory activity via IL-6. We found that PDX stimulated AMP-activated protein kinase (AMPK) phosphorylation, thereby inducing heme oxygenase 1 (HO-1) expression. This induction blocked hepatic gluconeogenesis by suppressing endoplasmic reticulum (ER) stress in hepatocytes under hyperlipidemic conditions. These effects were significantly dampened by silencing AMPK or HO-1 expression with small interfering RNA (siRNA). We also demonstrated that administration of PDX to high fat diet (HFD)-fed mice resulted in increased hepatic AMPK phosphorylation and HO-1 expression, whereas hepatic ER stress was substantially attenuated. Furthermore, PDX treatment suppressed the expression of gluconeogenic genes, thereby decreasing blood glucose levels in HFD-fed mice. In conclusion, our findings suggest that PDX inhibits hepatic gluconeogenesis via AMPK-HO-1-dependent suppression of ER stress. Thus, PDX may be an effective therapeutic target for the treatment of insulin resistance and type 2 diabetes through the regulation of hepatic gluconeogenesis. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Pulsed laser deposited KY3F10: Ho3+ thin films: Influence of target to substrate

    CSIR Research Space (South Africa)

    Debelo, NG

    2017-04-01

    Full Text Available The influence of target to substrate distance (dts) on the structural, morphological and photoluminescence (PL) properties of commercially obtained KY3F10 : Ho3+ phosphor thin films prepared by pulsed laser deposition is investigated for dts values...

  7. Complexes of 4-chlorophenoxyacetates of Nd(III), Gd(III) and Ho(III)

    International Nuclear Information System (INIS)

    Ferenc, W.; Bernat, M; Gluchowska, H.W.; Sarzynski, J.

    2010-01-01

    The complexes of 4-chlorophenoxyacetates of Nd(III), Gd(III) and Ho(III) have been synthesized as polycrystalline hydrated solids, and characterized by elemental analysis, spectroscopy, magnetic studies and also by X-ray diffraction and thermogravimetric measurements. The analysed complexes have the following colours: violet for Nd(III), white for Gd(III) and cream for Ho(III) compounds. The carboxylate groups bind as bidentate chelating (Ho) or bridging ligands (Nd, Gd). On heating to 1173K in air the complexes decompose in several steps. At first, they dehydrate in one step to form anhydrous salts, that next decompose to the oxides of respective metals. The gaseous products of their thermal decomposition in nitrogen were also determined and the magnetic susceptibilities were measured over the temperature range of 76-303K and the magnetic moments were calculated. The results show that 4-chlorophenoxyacetates of Nd(III), Gd(III) and Ho(III) are high-spin complexes with weak ligand fields. The solubility value in water at 293K for analysed 4-chlorophenoxyacetates is in the order of 10 -4 mol/dm 3 . (author)

  8. Magnetism and superconductivity in Eu(Ho)Mo/sub 6/S/sub 8/

    Energy Technology Data Exchange (ETDEWEB)

    Capone, D.W. II; Lai Fook, M.S.; Guertin, R.P.; Hinks, D.G.; Dunlap, B.D.; Foner, S.; Abou-Aly, A.I.; Brooks, J.S.

    1984-10-01

    A variety of ambient and high pressure experimental results reveal the interplay between magnetism and superconductivity in Ho doped samples of the pressure induced superconductor, EuMo/sub 6/S/sub 8/. Ho concentrations up to 50 atomic percent of the rare earth ions were used. High resolution magnetic measurements are consistent with the crystalline electric field ground state for the Ho/sup 3 +/ ions being a magnetic doublet consisting largely of J/sub z/ = 18. The results of high pressure magnetization experiments reveal negligible effects of reduced lattice constant on the rare earth-rare earth interactions. Resistivity in a 10 atomic percent sample for P = 10 kbar shows the suppression of a P = 0 structural transition, metallic conductivity down to low temperatures, and finally superconductivity at 8 K. The upper critical field, H/sub c2/(T), for this sample was measured for P = 7, 10 and 12 kbar and showed strong reentrant behavior (dH/sub c2/(T)/dT > 0 as T ..-->.. 0 K). A minimum with field in the resistivity above H/sub c2/ was also observed at lowest temperatures. The H/sub c2/(T) data are compared with those of EuMo/sub 6/S/sub 8/ at high pressure, which shows positive curvature, and HoMo/sub 6/S/sub 8/, in which superconductivity is quenched by ferromagnetism at low temperatures. 14 references, 4 figures.

  9. Magnetism and superconductivity in Eu(Ho)Mo6S8

    International Nuclear Information System (INIS)

    Capone, D.W. II; Lai Fook, M.S.; Guertin, R.P.; Hinks, D.G.; Dunlap, B.D.; Foner, S.; Abou-Aly, A.I.; Brooks, J.S.

    1984-10-01

    A variety of ambient and high pressure experimental results reveal the interplay between magnetism and superconductivity in Ho doped samples of the pressure induced superconductor, EuMo 6 S 8 . Ho concentrations up to 50 atomic percent of the rare earth ions were used. High resolution magnetic measurements are consistent with the crystalline electric field ground state for the Ho 3+ ions being a magnetic doublet consisting largely of J/sub z/ = 18. The results of high pressure magnetization experiments reveal negligible effects of reduced lattice constant on the rare earth-rare earth interactions. Resistivity in a 10 atomic percent sample for P = 10 kbar shows the suppression of a P = 0 structural transition, metallic conductivity down to low temperatures, and finally superconductivity at 8 K. The upper critical field, H/sub c2/(T), for this sample was measured for P = 7, 10 and 12 kbar and showed strong reentrant behavior (dH/sub c2/(T)/dT > 0 as T → 0 K). A minimum with field in the resistivity above H/sub c2/ was also observed at lowest temperatures. The H/sub c2/(T) data are compared with those of EuMo 6 S 8 at high pressure, which shows positive curvature, and HoMo 6 S 8 , in which superconductivity is quenched by ferromagnetism at low temperatures. 14 references, 4 figures

  10. Experimental study of the interaction of HO2 radicals with soot surface.

    Science.gov (United States)

    Bedjanian, Yuri; Lelièvre, Stéphane; Le Bras, Georges

    2005-01-21

    The reaction of HO2 with toluene and kerosene flame soot was studied over the temperature range 240-350 K and at P = 0.5-5 Torr of helium using a discharge flow reactor coupled to a modulated molecular beam mass spectrometer. A flat-flame burner was used for the preparation and deposition of soot samples from premixed flames of liquid fuels under well controlled and adjustable combustion conditions. The independent of temperature in the range 240-350 K value of gamma = (7.5 +/- 1.5) x 10(-2) (calculated with geometric surface area) was found for the uptake coefficient of HO2 on kerosene and toluene soot. No significant deactivation of soot surface during its reaction with HO2 was observed. Experiments on soot ageing under ambient conditions showed that the reactivity of aged soot is similar to that of freshly prepared soot samples. The results show that the HO2 + soot reaction could be a significant loss process for HOx in the urban atmosphere with a potential impact on photochemical ozone formation. In contrast this process will be negligible in the upper troposphere even in flight corridors.

  11. Neutron diffraction from HoNi2B2C

    DEFF Research Database (Denmark)

    Tomy, C.V.; Chang, L.J.; Paul, D.M.

    1995-01-01

    RENi(2)B(2)C (RE = rare-earth) are quaternary compounds which exhibit a considerable degree of interaction between their superconducting and magnetic properties. The Ho variant is found to become superconducting at T-c = 9 K, but anomalous behaviour is observed in the low-field magnetic properties...... at T demonstrate that at low temperatures (T

  12. Mechanisms of HO-1 mediated attenuation of renal immune injury: a gene profiling study.

    Science.gov (United States)

    Duann, Pu; Lianos, Elias A

    2011-10-01

    Using a mouse model of immune injury directed against the renal glomerular vasculature and resembling human forms of glomerulonephritis (GN), we assessed the effect of targeted expression of the cytoprotective enzyme heme oxygenase (HO)-1. A human (h) HO-1 complementary DNAN (cDNA) sequence was targeted to glomerular epithelial cells (GECs) using a GEC-specific murine nephrin promoter. Injury by administration of antibody against the glomerular basement membrane (anti-GBM) to transgenic (TG) mice with GEC-targeted hHO-1 was attenuated compared with wild-type (WT) controls. To explore changes in the expression of genes that could mediate this salutary effect, we performed gene expression profiling using a microarray analysis of RNA isolated from the renal cortex of WT or TG mice with or without anti-GBM antibody-induced injury. Significant increases in expression were detected in 9 major histocompatibility complex (MHC)-class II genes, 2 interferon-γ (IFN-γ)-inducible guanosine triphosphate (GTP)ases, and 3 genes of the ubiquitin-proteasome system. The increase in MHC-class II and proteasome gene expression in TG mice with injury was validated by real-time polymerase chain reaction (PCR) or Western blot analysis. The observations point to novel mechanisms underlying the cytoprotective effect of HO-1 in renal immune injury. Copyright © 2011. Published by Mosby, Inc.

  13. HO2 measurements at atmospheric concentrations using a chemical ionization mass spectrometry

    Science.gov (United States)

    Albrecht, S.; Novelli, A.; Hofzumahaus, A.; Kang, S.; Baker, Y.; Mentel, T. F.; Fuchs, H.

    2017-12-01

    Correct and precise measurements of atmospheric radical species are necessary for a better understanding of the oxidative capacity of the atmosphere. Due to the reactivity of radicals, and their consequent low concentrations, direct measurements of these species are particularly challenging and have been proven in the past to be affected by interfering species. Here we present a chemical ionization source coupled to an APi-HR-TOF-MS (Aerodyne Research Inc.), which has a limit of detection for HO2 radicals well below its atmospheric concentrations ( 1 x 108 molecules cm-3). The instrument was calibrated with a well-established and characterized HO2 calibration source in use for the laser induced fluorescence instrument in the Forschungszentrum Jülich. Within the source, a well characterized amount of HO2 radicals is produced after photolysis of water by a mercury lamp. In addition, several experiments were performed in the atmosphere simulation chamber SAPHIR at the Forschungszentrum Jülich to test for potential interferences. Measurements of HO2 radicals were concurrently detected by a laser induced fluorescence instrument allowing for the comparison of measurements within the two different and independent techniques for various atmospheric conditions regarding concentrations of O3, NOx and VOCs. Results from the intercomparison together with the calibration procedure of the instrument and laboratory characterization will be presented.

  14. The fluorite-pyrochlore transformation of Ho2-yNdyZr2O7

    International Nuclear Information System (INIS)

    Clements, Richard; Hester, James R.; Kennedy, Brendan J.; Ling, Chris D.; Stampfl, Anton P.J.

    2011-01-01

    Twelve members of the Ho 2-y Nd y Zr 2 O 7 series, prepared using conventional solid state methods, have been characterised by neutron powder diffraction. Ho 2 Zr 2 O 7 has a defect fluorite structure whereas Nd 2 Zr 2 O 7 is found to adopt the ordered pyrochlore structure with the composition induced fluorite-pyrochlore transformation occurring near y=1. Rietveld analysis on the neutron data for all the compositions reveals an increase in lattice parameter as a function of y across the entire series, with a small discontinuity associated with the transformation. The neutron profile results suggest that domains of pyrochlore-type initially begin to form before crystallising into a separate phase, and therefore that anion and cation ordering processes are distinct. There is a strong correlation between the extent of disorder in the anion sublattice and the x-parameter of 48f oxygen. These results point the way to a better understanding of the stability observed in pyrochlore structures. - Graphical abstract: Neutron diffraction profiles for Nd 2-y Ho y Zr 2 O 7 type oxides reveal details of the transformation from the ordered pyrochlore structure (y=0) to the disordered fluorite structure (y=2). Highlights: → Structures of twelve members of the Ho 2-y Nd y Zr 2 O 7 series studied using neutron powder diffraction. → Domains of pyrochlore-type materials form at low doping levels. → Higher doping stabilises the pyrochlore. → Anion and cation ordering processes are distinct.

  15. Optimalizace odpadového hospodářství farmaceutické firmy

    OpenAIRE

    Krystýnová, Hana

    2012-01-01

    Diplomová práce s názvem Optimalizace odpadového hospodářství farmaceutické firmy se nejprve zabývá základními pojmy, legislativními požadavky pro původce odpadu z hlediska vznikajících odpadů. Následuje analýza hospodaření s odpady ve zvoleném farmaceutickém podniku na výrobu generických léčiv. Dalším cílem práce je navrhnout možnosti optimalizace stávajícího systému odpadového hospodářství s ohledem na ochranu životního prostředí. The diploma thesis with the title Optimization of waste m...

  16. Psychomteric Validation of the Health of Nation Outcome Scales (HoNOS) in Traumatized Refugees

    DEFF Research Database (Denmark)

    Palic, Sabina; Elklit, Ask; Makransky, Guido

    -treatment data from 448 consecutive patients at three Danish psychiatric clinics for refugees. A10-item HoNOS version (physical problems and daily function items excluded) of pre-treatment data fit the Rasch model well. A cross validation showed excellent fit of the post-treatment data to the 10-item model...

  17. Levels in 159Ho as populated from decay of 159Er

    International Nuclear Information System (INIS)

    Boutet, J.

    1977-06-01

    The level scheme of the odd proton nucleus 159 Ho has been investigated using Ge(Li) and Si(Li) detectors. Results of γ-ray singles, conversion electron spectra and coincidence experiments are reported. Assignments are made for several energy levels

  18. HoBi-like viruses – the typical 'atypical bovine pestivirus'

    Science.gov (United States)

    HoBi-like viruses, also referred to as bovine viral diarrhea virus 3 (BVDV-3) and atypical pestivirus, have been proposed as a new putative bovine pestivirus species. These viruses were first identified in the last decade and are currently distributed in at least three continents. Published findings...

  19. Taurine effects on 45Ca2+ transport in retinal subcellular fractions

    International Nuclear Information System (INIS)

    Pasantes-Morales, H.; Ademe, R.M.; Lopez-Colome, A.M.

    1979-01-01

    The effect of taurine on 45 Ca 2+ transport by subcellular fractions from the chick retina was examined. An inhibitory action of taurine on 45 Ca 2+ uptake was observed in retinal fractions incubated for 1-5 min in a Krebs-bicarbonate medium, pH 7.4. In the crude nuclear fraction, 25 mM taurine produced a decrease of 50% in 45 Ca 2+ uptake; in the crude synaptosomal fraction, taurine reduced 45 Ca 2+ accumulation by 70%; the maximum inhibitory effect of taurine on 45 Ca 2+ uptake (80%) was observed in a fraction containing outer segments and pigment epithelium cells. Taurine effect was specific, dose-dependent and related to osmotically sensitive particles. The results suggest a role of taurine in the regulation of calcium fluxes in the retina. (Auth.)

  20. Effect of Ca-Fe oxides additives on NOx reduction in iron ore sintering

    Institute of Scientific and Technical Information of China (English)

    Zhi-yuan Yu; Xiao-hui Fan; Min Gan; Xu-ling Chen

    2017-01-01

    As the emission control regulations get stricter, the NOx reduction in the sintering process becomes an important environmental concern owing to its role in the formation of photochemical smog and acid rain. The NOx emissions from the sintering machine account for 48% of total amount from the iron and steel industry.Thus, it is essential to reduce NOx emissions from the sintering machine, for the achievement of clean production of sinter.Ca-Fe oxides, serving as the main binding phase in the sinter, are therefore used as additives into the sintering mixture to reduce NOx emissions.The results show that the NOx re-duction ratio achieves 27.76% with 8% Ca-Fe oxides additives since the Ca-Fe oxides can advance the ig-nition and inhibit the nitrogen oxidation compared with the conventional condition.Meanwhile, the exist-ence of Ca-Fe oxides was beneficial to the sinter quality since they were typical low melting point com-pounds.The optimal mass fraction of Ca-Fe oxides additives should be less than 8% since the permeability of sintering bed was significantly decreased with a further increase of the Ca-Fe oxides fines, inhibiting the mineralization reaction of sintering mixture.Additionally, the appropriate particle size can be obtained when mixing an equal amount of Ca-Fe oxides additives of -0.5 mm and 0.5-3.0 mm in size.

  1. Feasibility of converting hi-speed processor for processing Kodak film types 7381/7271 (16mm) and 5381/5271 (35mm) using Kodak ECP chemistry

    Science.gov (United States)

    Weinstein, M. S.

    1974-01-01

    Testing conducted to determine the feasibility of converting the 16/35/70 hi-speed processor to process Kodak film types 7381/7271 (16mm) and 5381/5271 (35mm) color negative films using Kodak ECP chemistry is described.

  2. Concentrations of OH and HO2 radicals during NAMBLEX: measurements and steady state analysis

    Directory of Open Access Journals (Sweden)

    S. C. Smith

    2006-01-01

    Full Text Available OH and HO2 concentrations were measured simultaneously at the Mace Head Atmospheric Research Station in the summer of 2002 during the NAMBLEX (North Atlantic Marine Boundary Layer EXperiment field campaign. OH was measured by laser-induced fluorescence employing the FAGE (Fluorescence Assay by Gas Expansion technique, with a mean daytime detection limit of 2.7×105 molecule cm−3 (5 min acquisition period; signal-to-noise ratio = 1. HO2 was detected as OH following its chemical conversion through addition of NO, with a mean detection limit of 4.4×106 molecule cm−3. The diurnal variation of OH was measured on 24 days, and that of HO2 on 17 days. The local solar noon OH concentrations ranged between (3–8×106 molecule cm−3, with a 24 h mean concentration of 9.1×105 molecule cm−3. The local solar noon HO2 concentrations were (0.9–2.1×108 molecule cm−3 (3.5–8.2 pptv, with a 24 h mean concentration of 4.2×107 molecule cm−3 (1.6 pptv. HO2 radicals in the range (2–3×107 molecule cm−3 were observed at night. During NAMBLEX, a comprehensive suite of supporting measurements enabled a detailed study of the behaviour of HOx radicals under primarily clean marine conditions. Steady state expressions are used to calculate OH and HO2 concentrations and to evaluate the effect of different free-radical sources and sinks. The diurnally averaged calculated to measured OH ratio was 1.04±0.36, but the ratio displays a distinct diurnal variation, being less than 1 during the early morning and late afternoon/evening, and greater than 1 in the middle of the day. For HO2 there was an overprediction, with the agreement between calculated and measured concentrations improved by including reaction with measured IO and BrO radicals and uptake to aerosols. Increasing the concentration of IO radicals included in the calculations to above that measured by a DOAS instrument with an absorption path located mainly over the ocean, reflecting the

  3. Our first clinical experience with radiosynoviorthesis by means of (166)Ho-holmium-boro-macroaggregates.

    Science.gov (United States)

    Kraft, Otakar; Kasparek, R; Ullmann, V; Melichar, F; Kropacek, M; Mirzajevov, M

    2005-01-01

    In this paper, we evaluate the therapeutic and adverse effects of the application of 166-holmium-boro-macroaggregates (HMBA) in radiosynovectomy (RSO) of the knees. We assessed the efficacy and safety of (166)Ho-HBMA in a prospective clinical trial in patients suffering from chronic synovitis. An effective component of radiopharmaceutical (166)Ho-boro-macroaggregates is radionuclide (166)Ho which has both beta-emission and gamma-emission. The physical half-life time of 166 Ho is 26.8 hours. After application of the radiopharmaceutical into a joint cavity, the effect of beta-emission causes radiation necrosis of pathologically changed (inflamed) synovial membrane. From 15th April 2005, we have started RSO of knees by means of new radiopharmaceutical (166)Ho-boro-macroaggregates in patients with gonarthrosis, rheumatoid arthritis, chronic synovitis, psoriatic arthritis, gout arthropathy. Seventeen intra-articular injections were performed in fifteen patients receiving a mean activity of 972 MBq (range: 904-1,057 MBq) (166)Ho-HMBA. The patients were hospitalized for three days. Side effects were evaluated during hospital stay and after 6-8 weeks. Static scintigraphy of knee joints and measurements of blood radioactivity were performed. Therapeutic effects were evaluated after 6-8 weeks. In 2 hours and 2 days after application, we proved, by means of knee and inguinal scintigraphy, only insignificant radiopharmaceutical leakage from the joint cavity to the inguinal lymph nodes in four patients. In treated patients, no serious adverse effects occurred. Nine patients were without complaints; 4 patients had slight knee exsudation and 2 patients had great exsudation. Therapeutic effects after 6-8 weeks were as follows: 2 patients were without pain, 9 with lower pain, 3 with the same pain and 1 patient with increased pain. Joint motion was improved in 7 patients, remained the same in 7 patients and was impaired in 1 patient. Analgesics consumption was lower in 5 patients

  4. Neutron activation of microspheres containing 165Ho: theoretical and experimental radionuclidic impurities study

    International Nuclear Information System (INIS)

    Squair, Peterson L.; Pozzo, Lorena; Ivanov, Evandro; Osso Junior, Joao A.

    2011-01-01

    The 166 Ho microspheres are potentially interesting for medical applications for treatment of many tumors. The internal radionuclide therapy can use polymer or glass device that provides structural support for the radionuclide. After activation, beta minus emission of 166 Ho (T 1/2 =26.8h, β - E max =1.84 MeV, γ E p =80.6 keV) can be used for therapeutic purposes. The aim of this work is study the influence of radionuclide impurities between End of Bombardment (EOB) and the medical application. The appropriate specific activities and purity along decay should be adequate for their safe and efficient medical applications. The good practices on neutron activation techniques are choice a high purity target to avoid production of undesirable radionuclides and when possible with enriched targets to obtain higher specific activity. In this work the target used was Ho 2 O 3 and polymeric microspheres containing holmium acetylacetonate (HoAcAc) manufactured at the Biotechnology Center-IPEN/CNEN-SP. Three conditions were evaluated: preliminary test with 1.0x10 13 n.cm -2 s -1 for 1.0 hour; nowadays maximum capability of IEA-R1 reactor with 5.0x10 13 n.cm -2 s -1 for 64.0 hours and the ideal IEA-R1 operation with 5.0x10 13 n.cm -2 s -1 for 120.0 hours. Considering the sample with 99.9% 165 Ho purity and 0.1% for each impurities elements with its natural abundance, the highest radionuclidic impurity is the Lutetium followed by Ytterbium, Lanthanum and Cerium. The intrinsic radionuclidic impurity of 166 mHo is less relevant. This review is important to identify the radionuclidic purity characteristics of the preliminary studies with different time and flux irradiation. The data produced in this paper will help to define strategies for the production of 166 Ho radioisotope at IEA-R1 IPEN/CNEN-SP reactor. (author)

  5. Weak transitions in 44Ca

    International Nuclear Information System (INIS)

    Tauhata, L.; Marques, A.

    1972-01-01

    Energy levels and gamma radiation transitions of Ca 44 are experimentally determined, mainly the weak transition at 564 KeV and 728 KeV. The decay scheme and the method used (coincidence with Ge-Li detector) are also presented [pt

  6. Proposed strategies for designing sustainable high-rise apartment buildings in Ho Chi Minh City responding to critical urban issues

    Science.gov (United States)

    Truong, Nguyen Hoang Long; Huan Giang, Ngoc; Binh Duong, Trong

    2018-03-01

    This paper aims at finding practical strategies for designing sustainable high-rise apartment buildings in Ho Chi Minh City responding to varied municipal issues. Two steps are made. Step-1 identifies the critical issues of Ho Chi Minh City which are associated with high-rise apartment building projects. Step-2 finds potential and applicable strategies which are solutions for the critical issues in Step-1 with reference of seven selected assessment methods. The study finds the set of 58 strategies applicable to designing sustainable high-rise apartment buildings in Ho Chi Minh City.

  7. Fundamental solution of bond pricing in the Ho-Lee stochastic interest rate model under the invariant criteria

    Directory of Open Access Journals (Sweden)

    Burhaneddin İzgi

    2017-03-01

    under the invariant criteria. We obtain transformations between Ho-Lee model with the corresponding linear (1 + 1 partial differential equation and the first Lie canonical form which is identical to the classical heat equation. These transformations help us to generate the fundamental solution for the Ho-Lee model with respect to the fundamental solution of the classical heat equation sense. Moreover, as a financial application of the Ho-Lee model, we choose the drift term from power functions and perform simulations via Milstein method. Furthermore, we obtain important results for the parameter calibration of the corresponding drift term by using the simulation results.

  8. Microstructural and dielectrical characterization of Ho doped BaTiO3 ceramics

    Directory of Open Access Journals (Sweden)

    Marjanović Miloš

    2014-01-01

    Full Text Available The Ho doped BaTiO3 ceramics, with different Ho2O3 content, ranging from 0.01 to 1.0 wt % Ho, were investigated regarding their microstructural and dielectric characteristics. Doped BaTiO3 were prepared using conventional solid state reaction and sintered at 1380°C for four hours. SEM analysis of Ho/BaTiO3 doped ceramics showed that the low doped samples exhibit mainly fairly uniform and homogeneous microstructure with the grain size ranged from 20-40 μm. In the samples with the higher dopant concentration the abnormal grain growth is inhibited and the grain size ranged between 2-10 μm. Measurements of dielectric properties were carried out as a function of temperature up to 180 °C at different frequencies. The samples doped with 0.01wt % of Ho, exhibit the high value of dielectric permittivity (εr = 2160 at room temperature. A nearly flat permittivity-response was obtained in specimens with higher additive content. Using a Curie-Weiss law and modified Curie-Weiss law the Curie constant (C, Curie temperature (Tc and a critical exponent of nonlinearity (g were calculated. The Curie temperature of doped samples were ranged from 128 to 130°C. The Curie constant for all series of samples decrease with increase of dopant concentration and the lowest values were observed on samples doped with 0.01 wt % of holmium. [Projekat Ministarstva nauke Republike Srbije, br. OI 172057: Directed synthesis, structure and properties of multifunctional materials i br. TR 32026

  9. Seasonal observations of OH and HO2 in the remote tropical marine boundary layer

    Directory of Open Access Journals (Sweden)

    Z. L. Fleming

    2012-02-01

    Full Text Available Field measurements of the hydroxyl radical, OH, are crucial for our understanding of tropospheric chemistry. However, observations of this key atmospheric species in the tropical marine boundary layer, where the warm, humid conditions and high solar irradiance lend themselves favourably to production, are sparse. The Seasonal Oxidant Study at the Cape Verde Atmospheric Observatory in 2009 allowed, for the first time, seasonal measurements of both OH and HO2 in a clean (i.e. low NOx, tropical marine environment. It was found that concentrations of OH and HO2 were typically higher in the summer months (June, September, with maximum daytime concentrations of ~9 × 106 and 4 × 108 molecule cm−3, respectively – almost double the values in winter (late February, early March. HO2 was observed to persist at ~107 molecule cm−3 through the night, but there was no strong evidence of nighttime OH, consistent with previous measurements at the site in 2007. HO2 was shown to have excellent correlations (R2 ~ 0.90 with both the photolysis rate of ozone, J(O1D, and the primary production rate of OH, P(OH, from the reaction of O(1D with water vapour. The analogous relations of OH were not so strong (R2 ~ 0.6, but the coefficients of the linear correlation with J(O1D in this study were close to those yielded from previous works in this region, suggesting that the chemical regimes have similar impacts on the concentration of OH. Analysis of the variance of OH and HO2 across the Seasonal Oxidant Study suggested that ~70% of the total variance could be explained by diurnal behaviour, with ~30% of the total variance being due to changes in air mass.

  10. Synthesis and characterization of composites HoMn_1_-_x(Ni,Co)_xO_3

    International Nuclear Information System (INIS)

    Santos, Cassio Morilla dos

    2011-01-01

    In this work was accomplished the synthesis process and structural and magnetic characterization of HoMn_1_-_X(Ni,Co)_XO_3 compounds of perovskite structure. The samples synthesis were performed through modified polymeric precursor method. After synthesis and solvent removal, the polymer resin formed was treated at 350 deg C/4h for organic constituents removal, followed by heating treatment at 500 deg C/4h and 900 deg C/20h to obtain the crystalline phase. For structural characterization, it was used D10B-XPD beam line of Laboratorio Nacional de Luz Sincrotron (LNLS), where X-rays wavelengths below cobalt, manganese and nickel absorption edge, were used. The formation of HoNi_0_._5_0Mn_0_._5_0O_3, HoCo_0_._5_0Mn_0_._5_0O_3 and HoNi_0_._2_5Co_0_._2_5Mn_0_._5_0O_3 phases were observed by X-ray diffraction technique. By Rietveld refinement method for sample HoNi_0_._2_5Co_0_._2_5Mn_0_._5_0O_3, it was determined that cobalt and nickel had similar occupations at the top and bottom of unit cell, while the manganese preferentially occupied plan 002. The magnetic response of samples was studied through magnetization curves according to the temperature function and the applied magnetic field. The ZFC curves showed a paramagnetic response associated to holmium magnetic moment, and ferromagnetism, antiferromagnetism and ferrimagnetism coexistence, due to sublattices formed by transition metals. The FC curves evidenced the spin reversal phenomenon, associated to the interaction between the sublattice formed by transition metals with sublattices formed by rare-earth, considering a mechanism of antiferromagnetic exchange interaction. (author)

  11. Does acetone react with HO2 in the upper-troposphere?

    Directory of Open Access Journals (Sweden)

    J. Lelieveld

    2012-02-01

    Full Text Available Recent theoretical calculations showed that reaction with HO2 could be an important sink for acetone (CH3C(OCH3 and source of acetic acid (CH3C(OOH in cold parts of the atmosphere (e.g. the tropopause region. This work details studies of HO2 + CH3C(OCH3 (CH32C(OHOO (R1 in laboratory-based and theoretical chemistry experiments; the atmospheric significance of Reaction (R1 was assessed in a global 3-D chemical model. Pulsed laser-kinetic experiments were conducted, for the first time, at the low-temperatures representative of the tropopause. Reaction with NO converted HO2 to OH for detection by laser induced fluorescence. Reduced yields of OH at T 2 by CH3C(OCH3 with a forward rate coefficient greater than 2 × 10−12 cm3 molecule−1 s−1. No evidence for Reaction (R1 was observed at T > 230 K, probably due to rapid thermal dissociation back to HO2 + CH3C(OCH3. Numerical simulations of the data indicate that these experiments were sensitive to only (R1a HO2-CH3C(OCH3 complex formation, the first step in (R1. Rearrangement (R1b of the complex to form peroxy radicals, and hence the atmospheric significance of (R1 has yet to be rigorously verified by experiment. Results from new quantum chemical calculations indicate that K1 is characterised by large uncertainties of at least an order of magnitude at T 3C(OCH3 near the tropopause, it cannot explain observations of CH3C(OOH throughout the troposphere.

  12. Spectroscopic properties of Ho{sup 3+}-doped K-Sr-Al phosphate glasses

    Energy Technology Data Exchange (ETDEWEB)

    Linganna, K.; Rathaiah, M.; Venkatramu, V. [Yogi Vemana University, Department of Physics, Kadapa (India); Jayasankar, C.K. [Sri Venkateswara University, Department of Physics, Tirupati (India)

    2014-05-15

    Trivalent holmium-doped K-Sr-Al phosphate glasses (P{sub 2}O{sub 5}-K{sub 2}O-SrO-Al{sub 2}O{sub 3}-Ho{sub 2}O{sub 3}) were prepared, and their spectroscopic properties have been evaluated using absorption, emission, and excitation measurements. The Judd-Ofelt theory has been used to derive spectral intensities of various absorption bands from measured absorption spectrum of 1.0 mol% Ho{sub 2}O{sub 3}-doped K-Sr-Al phosphate glass. The Judd-Ofelt intensity parameters (Ω{sub λ}, x 10{sup -20} cm{sup 2}) have been determined of the order of Ω{sub 2} = 11.39, Ω{sub 4} = 3.59, and Ω{sub 6} = 2.92, which in turn used to derive radiative properties such as radiative transition probability, radiative lifetime, branching ratios, etc. for excited states of Ho{sup 3+} ions. The radiative lifetimes for the {sup 5}F{sub 4}, {sup 5}S{sub 2}, and {sup 5}F{sub 5} levels of Ho{sup 3+} ions are found to be 169, 296, and 317 μs, respectively. The stimulated emission cross-section for 2.05-μm emission was calculated by the McCumber theory and found to be 9.3 x 10{sup -21} cm{sup 2}. The wavelength-dependent gain coefficient with population inversion rate has been evaluated. The results obtained in the titled glasses are discussed systematically and compared with other Ho{sup 3+}-doped systems to assess the possibility for visible and infrared device applications. (orig.)

  13. Ho:YAG laser: intervertebral disk cell interaction using three-dimensional cell culture system

    Science.gov (United States)

    Sato, Masato; Ishihara, Miya; Arai, Tsunenori; Asazuma, Takashi; Kikuchi, Toshiyuki; Kikuchi, Makoto; Fujikawa, Kyosuke

    2000-06-01

    The purpose of this study is to evaluate the influence on the intervertebral disc cells after laser irradiation using three- dimensional culture system and to clarify the optimum Ho:YAG laser irradiation condition on percutaneous laser disc decompression (PLDD) for lumbar disc herniation. Since the Ho:YAG laser ablation is characterized by water-vapor bubble dynamics, not only thermal effect but also acoustic effect on cell metabolism might occur in the intervertebral disc. We studied the disc cell reaction from the metabolic point of view to investigate photothermal and photoacoustic effects on three-dimensional cultured disc cell. Intervertebral discs were obtained from female 30 Japanese white rabbits weighing about 1 kg. A pulsed Ho:YAG laser (wavelength: 2.1 micrometer, pulse width: about 200 microseconds) was delivered through a 200 micrometer-core diameter single silica glass fiber. We used the Ho:YAG laser irradiation fluence ranging from 60 to approximately 800 J/cm2 at the fiber end. To investigate acoustic effect, the acoustic transducer constructed with polyvinylidene fluoride (PVdF) film and acoustic absorber was used to detect the stress wave. Thermocouple and thermography were used to investigate thermal effect. Concerning damage of plasma membrane and ability of matrix synthesis, thermal effect might mainly affect cell reaction in total energy of 54 J (closed to practically used condition), but in 27 J, acoustic effect might contribute to it. We found that total energy was key parameter among the optimum condition, so that temperature and/or stress wave may influence Ho:YAG laser-disc cell interactions.

  14. Clinical study of liver cancer (Hepatocellular carcinoma) by 166 Ho-CHICO

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J. T.; Yoo, H. S.; Lee, J. D.; Lee, D. Y.; Kim, E. K.; Yoo, N. C.; Shin, S. J.; Han, K. H. [Yonsei University, Seoul (Korea); Park, K. B. [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2000-04-01

    As having used Ho-166 Chitosan complex, this study was designed for the development of new therapeutic agent in the treatment of liver cancer (hepatocellular carcinoma). During the period of 3 years from April 1, 1997 to March 31, 2000, this project was successfully performed on the base of clinical experience with percutaneous Ho-166 CHICO injection in the treatment of liver cancer'. In order to evaluate the biodistribution and effect of Ho-166 CHICO was performed in 50 patients, who had the progressed liver cancer with range of 3-10cm in diameter. After the administration of the complex materials, we evaluated the therapeutic effect as well as complication by the follow-up study that included laboratory examination, radioactivity counting and various imaging modalities. 1) In animal experiment, radioactivity of target liver was ranged between 27-33% of total body one, urine excretion between 0.17-0.24 %. White blood cell and platelet counts start diminishing within 7 days and at maximum within 4 weeks after administration of complex materials. In tissue changes of target liver was revealed no significant change in the tumor dose of Ho-166, but periportal fibrosis and massive tissue necrosis in the high ones. 2) In clinical study, total necrosis of tumor is 66%, partial 10% and non-response 24% among 50 patients' liver cancer. The most important complication were leukopenia and thrombocytopenia (82%), the remained was abdominal pain(34%), skin reaction(12%), bile duct obstruction(10%), liver abscess(6%) etc. Conclusively intraarterial injection of Ho-166 CHICO was effective in the treatment of larger and progressed liver cancer. 19 refs., 14 figs., 8 tabs. (Author)

  15. Control of ciliary motility by Ca2+: Integration of Ca2+-dependent functions and targets for Ca2+ action

    International Nuclear Information System (INIS)

    Evans, T.C.

    1988-01-01

    To identify functions that regulate Ca 2+ -induced ciliary reversal in Paramecium, mutants defective in terminating depolarization-induced backward swimming were selected. Six independent recessive mutations (k-shy) comprising two complementation groups, k-shyA and k-shyB, were identified. All mutants exhibited prolonged backward swimming in depolarizing solutions. Voltage clamp studies revealed that mutant Ca 2+ current amplitudes were reduced, but could be restored to wild type levels by EGTA injection. The recovery of the mutant Ca 2+ current from Ca 2+ -dependent inactivation, and the decay of the Ca 2+ -dependent K + and Ca 2+ -dependent Na + currents after depolarization were slow in k-shy compared to wild type. To identify protein targets of Ca 2+ action, ciliary proteins that interact with calmodulin (CaM) were characterized. With a 125 I-CaM blot assay, several CaM-binding proteins were identified including axonemal, soluble, and membrane-bound polypeptides. Competitive displacement studies with unlabeled Paramecium CaM, bovine CaM, and troponinC suggested that both protein types bind CaM with high affinity and specificity. To examine the presence of CaM-binding sites in intact axonemes, a filtration binding assay was developed

  16. Ca isotopic fractionation patterns in forest ecosystems

    Science.gov (United States)

    Kurtz, A. C.; Takagi, K.

    2012-12-01

    Calcium stable isotope ratios are an emerging tracer of the biogeochemical cycle of Ca that are just beginning to see significant application to forest ecosystems. The primary source of isotopic fractionation in these systems is discrimination against light Ca during uptake by plant roots. Cycling of vegetation-fractionated Ca establishes isotopically distinct Ca pools within a forest ecosystem. In some systems, the shallow soil exchangeable Ca pool is isotopically heavy relative to Ca inputs. This has been explained by preferential removal of light Ca from the soil. In other systems, the soil exchange pool is isotopically light relative to inputs, which is explained by recycling of plant-fractionated light Ca back into soil. Thus vegetation uptake of light Ca has been called on to account for both isotopically heavy and light Ca in the shallow soil exchange pools. We interpret patterns in ecosystem δ44Ca with the aid of a simple box model of the forest Ca cycle. We suggest that the δ44Ca of exchangeable Ca in the shallow soil pool primarily reflects the relative magnitude of three key fluxes in a forest Ca cycle, 1) the flux of external Ca into the system via weathering or atmospheric deposition, 2) the uptake flux of Ca from soils into the vegetation pool, and 3) the return flux of Ca to shallow soils via remineralization of leaf litter. Two observations that emerge from our model may aid in the application of Ca isotopes to provide insight into the forest Ca cycle. First, regardless of the magnitude of both vegetation Ca uptake and isotopic fractionation, the δ44Ca of the soil exchange pool will equal the input δ44Ca unless the plant uptake and remineralization fluxes are out of balance. A second observation is that the degree to which the shallow soil exchange pool δ44Ca can differ from the input ratio is controlled by the relative rates of biological uptake and external Ca input. Significant differences between soil exchange and input δ44Ca are seen only

  17. Investigation of complexes with bone affinity using the In vivo generator system 166 Dy/166 Ho

    International Nuclear Information System (INIS)

    Pedraza L, M.

    2006-01-01

    The importance of this original research lies in the fact that it has proven that the [ 166 Dy]Dy/ 166 Ho-EDTMP in vivo generator system is a stable complex that can be used as a therapeutic radiopharmaceutical. Multiple myeloma and other hematological malignancies have been treated by myeloablative radiotherapy/chemotherapy and subsequent stem cell transplantation. Bone-seeking radiopharmaceuticals such as 166 Ho-DOTMP or 153 Sm-DTMP, have been proposed for delivering ablative radiation doses to marrow in multiple myeloma and other hematological malignancies or have shown excellent results in palliative bone metastasis pain therapy, respectively. As lanthanides have similar chemical characteristics the phosphonate with bone affinity (EDTMP) labeled with Dy/Ho can be used for marrow ablation while causing minimal irradiation to normal organs. This in vivo generator system has not been previously reported. The aim of this research was to label EDTMP (ethylene diamine tetramethylene phosphonate) with 166 Dy/ 166 Ho; to evaluate the in vitro and in vivo stability of both 166 Dy-EDTMP and 166 Ho-EDTMP complexes when the daughter 166 Ho is formed as a dysprosium decay product; to determine the bone marrow cytotoxic and genotoxic effect in mice and to evaluate, by histopathology, the myeloablative potential of the [ 166 Dy]Dy/ 166 Ho-EDTMP in vivo generator system. 166 Dy was obtained by neutron irradiation of enriched 164 Dy 2 O 3 in a TRIGA Mark III reactor. Labeling was carried out in an aqueous phosphate medium at pH 8.0 by addition of 166 DyCl 3 to EDTMP at a molar ratio 1:1.75, with >99 % radiochemical purity, as determined by thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC). In vitro studies demonstrated that 166 Dy/ 166 Ho-EDTMP is unstable after dilution in saline but stable in human serum with no translocation of the daughter nucleus subsequent to β decay of 166 Dy, which could release free 166 Ho 3+ . Biodistribution in mice

  18. MmWave Vehicle-to-Infrastructure Communication :Analysis of Urban Microcellular Networks

    Science.gov (United States)

    2017-05-01

    Vehicle-to-infrastructure (V2I) communication may provide high data rates to vehicles via millimeterwave (mmWave) microcellular networks. This report uses stochastic geometry to analyze the coverage of urban mmWave microcellular networks. Prior work ...

  19. Srovnání některých dat registru alert-cz s daty dřívějšího pilotního registru akutního infarktu myokardu

    Czech Academy of Sciences Publication Activity Database

    Peleška, Jan; Reissigová, Jindra; Tomečková, Marie; Grünfeldová, H.; Janský, P.; Monhart, Z.; Vojáček, J.; Widimský, J.; Zvárová, Jana

    2010-01-01

    Roč. 52, Suppl. 1 - CD ROM (2010), A248 ISSN 0010-8650. [Výroční sjezd České kardiologické společnosti /18./. 16.05.2010-19.05.2010, Brno] R&D Projects: GA MŠk(CZ) 1M06014 Institutional research plan: CEZ:AV0Z10300504 Keywords : registr akutního infarktu myokardu * rizikové faktory infarktu myokardu * PCI a akutní farmakoterapie infarktu myokardu Subject RIV: IN - Informatics, Computer Science

  20. Sportautode MM

    Index Scriptorium Estoniae

    2012-01-01

    Võrdlustestis ringrajal võtavad mõõtu üheksa sportautot: Lamborghini Aventador LP 700-4, Mercedes-Benz SL 500, Audi RS 5, Nissan GT-R, Bentley Continental Supersports Cabrio ISR, SLS AMG Roadster, Porsche 911 Carrera S, McLaren MP4-12C

  1. Stochastic Geometric Coverage Analysis in mmWave Cellular Networks with a Realistic Channel Model

    DEFF Research Database (Denmark)

    Rebato, Mattia; Park, Jihong; Popovski, Petar

    2017-01-01

    Millimeter-wave (mmWave) bands have been attracting growing attention as a possible candidate for next-generation cellular networks, since the available spectrum is orders of magnitude larger than in current cellular allocations. To precisely design mmWave systems, it is important to examine mmWa...

  2. The effect of H2O gas on volatilities of planet-forming major elements. I - Experimental determination of thermodynamic properties of Ca-, Al-, and Si-hydroxide gas molecules and its application to the solar nebula

    Science.gov (United States)

    Hashimoto, Akihiko

    1992-01-01

    The vapor pressures of Ca(OH)2(g), Al(OH)3(g), and Si(OH)4(g) molecules in equilibrium with solid calcium-, aluminum, and silicon-oxides, respectively, were determined, and were used to derive the heats of formation and entropies of these species, which are expected to be abundant under the currently postulated physical conditions in the primordial solar nebula. These data, in conjunction with thermodynamic data from literature, were used to calculate the relative abundances of M, MO(x), and M(OH)n gas species and relative volatilities of Fe, Mg, Si, Ca, and Al for ranges of temperature, total pressure, and H/O abundance ratio corresponding to the plausible ranges of physical conditions in the solar nebula. The results are used to explain how Ca and Al could have evaporated from Ca,Al-rich inclusions in carbonaceous chondrites, while Si, Mg, and Fe condensed onto them during the preaccretion alteration of CAIs.

  3. California Basin Studies (CaBS)

    International Nuclear Information System (INIS)

    Gorsline, D.S.

    1991-01-01

    The California Continental Borderland's present configuration dates from about 4 to 5 X 10 6 years Before Present (B.P.) and is the most recent of several configurations of the southern California margin that have evolved after the North America Plate over-rode the East Pacific Rise about 30 X 10 6 years ago. The present morphology is a series of two to three northwest-southeast trending rows of depressions separated by banks and insular ridges. Two inner basins, Santa Monica and San Pedro, have been the site for the Department of Energy-funded California Basin Study (CaBS) Santa Monica and San Pedro Basins contain post-Miocene sediment thicknesses of about 2.5 and 1.5 km respectively. During the Holocene (past 10,000 years) about 10-12 m have accumulated. The sediment entered the basin by one or a combination of processes including particle infall (mainly as bioaggregates) from surface waters, from nepheloid plumes (surface, mid-depths and near-bottom), from turbidity currents, mass movements, and to a very minor degree direct precipitation. In Santa Monica Basin, during the last century, particle infall and nepheloid plume transport have been the most common processes. The former dominates in the central basin floor in water depths from 900 to 945 m. where a characteristic silt-clay with a typical mean diameter of about 0.006 mm, phi standard deviation

  4. Ca-48 handling for a cyclotron ECR ion source to produce highly intense ion beams

    International Nuclear Information System (INIS)

    Lebedev, V.Ya.; Bogomolov, S.L.; Dmitriev, S.N.; Kutner, V.B.; Shamanin, A.N.; Yakushev, A.B.

    2002-01-01

    Production of highly intense ion beams of 48 Ca is one of the main tasks in experiments carried out within the framework of the synthesis of new superheavy elements. 48 Ca is very rare and expensive isotope, therefore there is necessity to reach the high intensity of ion beams of the isotope at a low consumption rate. Analysis and our preliminary experiments have showed that the best way of producing highly intense calcium ion beams is evaporation of metallic calcium in an ECR ion source. So we have developed a technique of metallic 48 Ca production by reducing CaO (this chemical form is available at the market with 40-80% of 48 Ca ) with aluminium powder. We used two tantalum crucibles: a larger, with a mixture of CaO + Al heated up to 1250 deg C, which was connected to the smaller (2 mm I.D. and 30 mm long) in which calcium vapour condensed. The temperature distribution in the small crucible was about 50 deg C at the bottom and about 500 deg C in the middle of the crucible. The pressure inside of the set-up was between 0.1 and 1 Pa. The production rate of metallic 48 Ca was 10-20 mg/h. The crucible with the condensed metallic Ca in argon atmosphere was transferred to the ECR-4M ion source, where it was inserted in a wired tubular oven and the calcium evaporation was controlled through the oven power supply. The application of metallic 48 Ca as the working substance for the ECR-4M ion source of the U-400 cyclotron of allowed us to approach a stable high intensity of 48 Ca ion beams: the intensities for the internal and external beams were 10 13 c -1 and 3.10 12 c -1 , respectively, at a consumption rate about 0.4 mg/h. A technique was developed for the reclamation of 48 Ca from the residue inside of the large crucible and from the inner parts of the ECR ion source. Extracting Ca from the inner parts of the ion source enabled us to save up to some 25% of the calcium used in the ECR ion source, so that the actual consumption rate was about 0.3 mg/h at the highest 48

  5. Highly efficient red upconversion fluorescence emission in Yb{sup 3+}/Ho{sup 3+}/Ce{sup 3+} codoped LaF{sub 3} nanocrystals

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Wei, E-mail: gaowei@xupt.edu.cn; Dong, Jun; Liu, Jihong; Yan, Xuewen

    2016-11-15

    The Yb{sup 3+}/Ho{sup 3+}/Ce{sup 3+} codoped LaF{sub 3} nanocrystals have been successfully prepared via a facile hydrothermal method. The significant enhancement in the red upconversion emission of Ho{sup 3+} is successfully obtained in LaF{sub 3}:Yb{sup 3+}/Ho{sup 3+} nanocrystals through introducing of Ce{sup 3+} under NIR excitation at 980 nm. The red-to-green emission ratio of Ho{sup 3+} is enhanced 18.9-fold with Ce{sup 3+} concentration increasing to 12%, which is due to the two efficient cross relaxation processes of {sup 5}I{sub 6} (Ho{sup 3+})+{sup 2}F{sub 5/2} (Ce{sup 3+})→{sup 5}I{sub 7} (Ho{sup 3+})+{sup 2}F{sub 7/2} (Ce{sup 3+}) and {sup 5}S{sub 2}/{sup 5}F{sub 4} (Ho{sup 3+})+{sup 2}F{sub 5/2} (Ce{sup 3+})→{sup 5}F{sub 5} (Ho{sup 3+})+{sup 2}F{sub 7/2} (Ce{sup 3+}) between Ho{sup 3+} and Ce{sup 3+} ions. The enhancement mechanism of red emission and conversion efficiency between Ho{sup 3+} and Ce{sup 3+} are investigated in detail.

  6. {sup 166} Ho-HA Evaluation as therapeutic agent for rheumatoid arthritis treatment; Evaluacion de {sup 166}Ho-Ha como agente terapeutico en el tratamiento de la artritis reumatoidea

    Energy Technology Data Exchange (ETDEWEB)

    Chandia, M; Errazu, X [Comision Chilena de Energia Nuclear, Santiago (Chile); Mendoza, P [Departamento de Medicina Nuclear, Hospital Militar, Santiago (Chile); Troncoso, F [Comision Chilena de Energia Nuclear, Santiago (Chile); Jofre, J; Sierralta, P [Departamento de Medicina Nuclear, Hospital Militar, Santiago (Chile)

    2003-01-01

    Aim: Rheumatoid arthritis is a limiting disease having, among its pathological features, the inflammation of synovial tissue with progressive and later destruction of the articulation. This lead to joint deformation and loss of its function, generating pain and reducing the mobility of the affected articulation. The aim was to evaluate {sup 166}Ho-Hydroxyapatite ({sup 166} Ho-HA) as potential radiopharmaceutical for the syntomatic treatment of chronic and acute arthritis Materials and Methods: {sup 166}Holmiun was produced by irradiation of Ho{sub 2}O{sub 3} at La Reina Research Reactor, Nuclear Chilean Energy Commission. Hydroxyapatite was in-house synthetized. Its labelling and quality controls follows the internationally accepted procedures. An antigen arthritis was induced to eight New Zealand rabbits with the {sup 166}Ho-HA radiochemical being administred thereafter in two dosage modalities (single and double). The compound therapeutic efficiency was evaluated based upon clinical improvement and images from the inflamated articulation using {sup 67}Ga citrate before and after {sup 166} Ho-HA injection. Results: The radiochemical purity of the innoculated compound was greater than 98% as measured under sterility conditions. Clinically, an inflamation reduction (2 cm), appetite improvement and general well being was observed. The {sup 166} Ho-HA distribution and localization was monitored using gamma camera images taken at 4 and 24 h. There was no evidence of extraarticular leakage. From the {sup 67}Ga citrate imaging, the acute group shows an overall improvement of well being corresponding to a lesser uptake at the inflamated articulation, regarding to the chronic group. The {sup 166}Ho-HA double dosis, compared to the single dosis, suggest a reduced uptake of {sup 67}Ga citrate at the inflamated tissue, meaning an increased therapeutic effect. Conclusions: {sup 166} Ho-HA is usefull as therapeutic agent for the syntomatic treatment of rheumatoideal arthritis

  7. SUBMILLIMETER ARRAY OBSERVATIONS TOWARD THE MASSIVE STAR-FORMING CORE MM1 OF W75N

    International Nuclear Information System (INIS)

    Minh, Y. C.; Su, Y.-N.; Liu, S.-Y.; Yan, C.-H.; Chen, H.-R.; Kim, S.-J.

    2010-01-01

    The massive star-forming core MM1 of W75N was observed using the Submillimeter Array with ∼1'' and 2'' spatial resolutions at 217 and 347 GHz, respectively. From the 217 GHz continuum we found that the MM1 core consists of two sources, separated by about 1'': MM1a (∼0.6 M sun ) and MM1b (∼1.4 M sun ), located near the radio continuum sources VLA 2/VLA 3 and VLA 1, respectively. Within MM1b, two gas clumps were found to be expanding away from VLA 1 at about ±3 km s -1 , as a result of the most recent star formation activity in the region. Observed molecular lines show emission peaks at two positions, MM1a and MM1b: sulfur-bearing species have emission peaks toward MM1a, but methanol and saturated species at MM1b. We identified high-temperature (∼200 K) gas toward MM1a and the hot core in MM1b. This segregation may result from the evolution of the massive star-forming core. In the very early phase of star formation, the hot core is seen through the evaporation of dust ice-mantle species. As the mantle species are consumed via evaporation the high-temperature gas species (such as the sulfur-bearing molecules) become bright. The SiO molecule is unique in having an emission peak exactly at the VLA 2 position, probably tracing a shock powered by VLA 2. The observed sulfur-bearing species show similar abundances both in MM1a and MM1b, whereas the methanol and saturated species show significant abundance enhancement toward MM1b, by about an order of magnitude, compared to MM1a.

  8. Bone Ablation at 2.94 mm Using the Free-Electron Laser and Er:YAG Laser

    Science.gov (United States)

    Ivanov, Borislav; Hakimian, Arman; Peavy, G. M.; Haglund, Richard

    2002-03-01

    Bone Ablation at 2.94 microns Using the Free-Electron Laser and Er:YAG Laser in Perfluorocarbon Compounds B. Ivanov^1, A. M. Hakimian^1, G. M. Peavy^2, R. F. Haglund, Jr.1 1Department of Physics and Astronomy, W. M. Keck Foundation Free-Electron Laser Center, Vanderbilt University, Nashville, TN 37235 2Beckman Laser Institute and Medical Clinic, College of Medicine, University of California, Irvine, CA 92612 We report studies on the efficiency of mid-IR laser ablation of cow cortical bone using the Vanderbilt free-electron laser (FEL), when irrigating the ablation zone with an inert and biocompatible perfluorocarbon compounds (PFC). At 2.94 microns, the bone matrix (mainly by water) absorbs the radiation while the PFCs transmit this wavelength, dissipate heat and acoustical stress, and prevent carbonization of the bone sample. The ablation rate, as a function of laser fluence, scanning speed and the type of PFC, was investigated. The laser fluence was estimated to be 5 J/cm^2 - 100 J/cm^2 with a laser focal spot diameter of 160 microns 500 microns and a scanning speed of 40 microns/s 2960 microns/s. The ablation rate was estimated from scanning electron microscopy to be 0.5 mm/s 2.4 mm/s. Comparisons of ablation rates with the FEL and a Er:YAG laser at 2.94 microns are being evaluated.

  9. Microstructure, biocorrosion and cytotoxicity evaluations of rapid solidified Mg-3Ca alloy ribbons as a biodegradable material.

    Science.gov (United States)

    Gu, X N; Li, X L; Zhou, W R; Cheng, Y; Zheng, Y F

    2010-06-01

    Rapidly solidified (RS) Mg–3Ca alloy ribbons were prepared by the melt-spinning technique at different wheel rotating speeds (15 m s(-1), 30 m s(-1) and 45 m s(-1) with the as-cast Mg–3Ca alloy ingot as a raw material. The RS45 Mg–3Ca alloy ribbon showed a much more fine grain size feature (approximately 200–500 nm) in comparison to the coarse grain size (50–100 μm)of the original as-cast Mg–3Ca alloy ingot. The corrosion electrochemical tests in simulated body fluid indicated that the corrosion rate of the as-cast Mg–3Ca alloy was strongly reduced by the RS procedure and tended to be further decreased with increasing wheel rotating speeds(1.43 mm yr(-1) for RS15, 0.94 mm yr(-1) for RS30 and 0.36 mm yr(-1) for RS45). The RS Mg–3Ca alloy ribbons showed more uniform corrosion morphology compared with the as-cast Mg–3Ca alloy after polarization. The cytotoxicity evaluation revealed that the three experimental as-spun Mg–3Ca alloy ribbon extracts did not induce toxicity to the L-929 cells,whereas the as-cast Mg–3Ca alloy ingot extract did. The L-929 cells showed more improved adhesion on the surfaces of the three as-spun Mg–3Ca alloy ribbons than that of the as-cast Mg–3Ca alloy ingot.

  10. Microstructure, biocorrosion and cytotoxicity evaluations of rapid solidified Mg-3Ca alloy ribbons as a biodegradable material

    Energy Technology Data Exchange (ETDEWEB)

    Gu, X N; Zhou, W R; Zheng, Y F [State Key Laboratory for Turbulence and Complex System and Department of Advanced Materials and Nanotechnology, College of Engineering, Peking University, Beijing 100871 (China); Li, X L [Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150001 (China); Cheng, Y, E-mail: yfzheng@pku.edu.c [Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871 (China)

    2010-06-01

    Rapidly solidified (RS) Mg-3Ca alloy ribbons were prepared by the melt-spinning technique at different wheel rotating speeds (15 m s{sup -1}, 30 m s{sup -1} and 45 m s{sup -1}) with the as-cast Mg-3Ca alloy ingot as a raw material. The RS45 Mg-3Ca alloy ribbon showed a much more fine grain size feature (approximately 200-500 nm) in comparison to the coarse grain size (50-100 {mu}m) of the original as-cast Mg-3Ca alloy ingot. The corrosion electrochemical tests in simulated body fluid indicated that the corrosion rate of the as-cast Mg-3Ca alloy was strongly reduced by the RS procedure and tended to be further decreased with increasing wheel rotating speeds (1.43 mm yr{sup -1} for RS15, 0.94 mm yr{sup -1} for RS30 and 0.36 mm yr{sup -1} for RS45). The RS Mg-3Ca alloy ribbons showed more uniform corrosion morphology compared with the as-cast Mg-3Ca alloy after polarization. The cytotoxicity evaluation revealed that the three experimental as-spun Mg-3Ca alloy ribbon extracts did not induce toxicity to the L-929 cells, whereas the as-cast Mg-3Ca alloy ingot extract did. The L-929 cells showed more improved adhesion on the surfaces of the three as-spun Mg-3Ca alloy ribbons than that of the as-cast Mg-3Ca alloy ingot.

  11. Microstructure, biocorrosion and cytotoxicity evaluations of rapid solidified Mg-3Ca alloy ribbons as a biodegradable material

    International Nuclear Information System (INIS)

    Gu, X N; Zhou, W R; Zheng, Y F; Li, X L; Cheng, Y

    2010-01-01

    Rapidly solidified (RS) Mg-3Ca alloy ribbons were prepared by the melt-spinning technique at different wheel rotating speeds (15 m s -1 , 30 m s -1 and 45 m s -1 ) with the as-cast Mg-3Ca alloy ingot as a raw material. The RS45 Mg-3Ca alloy ribbon showed a much more fine grain size feature (approximately 200-500 nm) in comparison to the coarse grain size (50-100 μm) of the original as-cast Mg-3Ca alloy ingot. The corrosion electrochemical tests in simulated body fluid indicated that the corrosion rate of the as-cast Mg-3Ca alloy was strongly reduced by the RS procedure and tended to be further decreased with increasing wheel rotating speeds (1.43 mm yr -1 for RS15, 0.94 mm yr -1 for RS30 and 0.36 mm yr -1 for RS45). The RS Mg-3Ca alloy ribbons showed more uniform corrosion morphology compared with the as-cast Mg-3Ca alloy after polarization. The cytotoxicity evaluation revealed that the three experimental as-spun Mg-3Ca alloy ribbon extracts did not induce toxicity to the L-929 cells, whereas the as-cast Mg-3Ca alloy ingot extract did. The L-929 cells showed more improved adhesion on the surfaces of the three as-spun Mg-3Ca alloy ribbons than that of the as-cast Mg-3Ca alloy ingot.

  12. A Devil in the Details: Matrix-Dependent 40Ca42Ca++/42Ca+ and Its Effects on Estimates of the Initial 41Ca/40Ca in the Solar System

    Science.gov (United States)

    McKeegan, K. D.; Liu, M.-C.

    2015-07-01

    Ian Hutcheon established that the molecular ion interference 40Ca42Ca++/42Ca+ on 41K+ is strongly dependent on the mineral analyzed. Correction for this "matrix effect" led to a downward revision of the initial 41Ca/40Ca of the solar system.

  13. Development of thin dosemeters of CaSO4: Dy for beta radiation detection

    International Nuclear Information System (INIS)

    Campos, L.L.

    1987-01-01

    Thin pellets of CaSO: Dy (0,20mm) were produced and tested in beta radiation fields. The Thermolumiscent (TL) characteristics studied were sensitivity, reproducibility, lower detection limit, linearity of TL response with absorved dose energy dependence. The results show the usefulness of this thin pellets in beta radiation detection. (Author) [pt

  14. The examination of Na-Ca effect on some qualitative and ...

    African Journals Online (AJOL)

    The effect of salt stress (NaCl) on shoot height (cm), root length (cm), dry and fresh weight (g), chlorophyll a and b, total chlorophyll (mg-1) and carotenoid amount was investigated in this study. In addition, the positive effects of Ca+2 (20 mM) were also investigated. Triticum durum Desf. Mirzabey, Kunduru-1149, and DH-6 ...

  15. Normal mediastinal and hilar lymph nodes evaluated by 5 mm slice bolus injection CT scan

    International Nuclear Information System (INIS)

    Yamamoto, Takako; Tsukada, Hiroshi; Koizumi, Naoya; Akita, Shinichi; Oda, Junichi; Sakai, Kunio

    1995-01-01

    We evaluated the number and size of normal mediastinal and hilar lymph nodes by 5 mm slice bolus injection CT (12 patients), compared with 10 mm slice CT (12 patients). More lymph nodes were clearly demonstrated by 5 mm slice CT than by 10 mm slice CT. Especially left-sided tracheobronchial (no.4), subaortic (no.5), subcarinal (no.7) and hilar lymph nodes were clearly visible. We concluded 5 mm slice bolus injection CT was useful to evaluate mediastinal and hilar lymph nodes. (author)

  16. Structure determination, electronic and optical properties of rubidium holmium polyphosphate RbHo(PO3)4

    Science.gov (United States)

    Zhu, Jing; Chen, Hui; Wang, Yude; Guan, Hongtao; Xiao, Xuechun

    2012-12-01

    Structural, optical, and electronic properties of a new alkali metal-rare earth polyphosphate, RbHo(PO3)4, have been investigated by means of single-crystal X-ray diffraction, power X-ray diffraction, elemental analysis, and spectral measurement. RbHo(PO3)4 crystallizes in the monoclinic with space group P21/n and Z = 4. It is described as a three-dimensional (3D) architecture built up of PO4 double spiral chains and HoO8 polyhedra by corner-sharing. The 11-coordinated rubidium atoms are located in infinite tunnels. Additionally, in order to gain further insight into the relationship between property and structure of RbHo(PO3)4, theoretical calculation based on the density functional theory (DFT) was performed using the total-energy code CASTEP.

  17. Structural and electronic effects of the solid-state amorphization and recrystallization of Cu--Ho thin films

    International Nuclear Information System (INIS)

    Venkert, A.; Shamir, N.; Talianker, M.; Atzmony, U.; Dariel, M.P.; Ben-Gurion University, Material Engineering, P.O. Box 653, Beer-Sheva, Israel)

    1987-01-01

    Amorphous alloys can be produced as the outcome of diffusion reaction between evaporated thin crystalline films. The Cu--Ho system is a favorable one for such a reaction to occur. The amorphization and the recrystallization of Cu--Ho multilayers has been previously observed using transmission electron microscopy. In the present study the various stages of the interdiffusion processes in this multilayer system were investigated by means of electron spectroscopy techniques. Auger electron spectroscopy depth profiling showed the evolution of the mixing process from the multilayer structure to its completion. The mixing process was accompanied by a shift without broadening of the x-ray photoelectron spectroscopy Ho 4d line. This shift is attributed to a charge transfer from the Ho ion. The lack of line broadening indicated that the mixing was completed down to the atomic level

  18. Study of Ho-doped Bi{sub 2}Te{sub 3} topological insulator thin films

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, S. E. [Department of Physics, Clarendon Laboratory, University of Oxford, Oxford OX1 3PU (United Kingdom); Department of Electrical Engineering, Stanford University, Stanford, California 94305 (United States); Collins-McIntyre, L. J.; Zhang, S. L.; Chen, Y. L.; Hesjedal, T., E-mail: Thorsten.Hesjedal@physics.ox.ac.uk [Department of Physics, Clarendon Laboratory, University of Oxford, Oxford OX1 3PU (United Kingdom); Baker, A. A. [Department of Physics, Clarendon Laboratory, University of Oxford, Oxford OX1 3PU (United Kingdom); Magnetic Spectroscopy Group, Diamond Light Source, Didcot OX11 0DE (United Kingdom); Figueroa, A. I.; Laan, G. van der [Magnetic Spectroscopy Group, Diamond Light Source, Didcot OX11 0DE (United Kingdom); Kellock, A. J.; Pushp, A.; Parkin, S. S. P. [IBM Almaden Research Center, 650 Harry Road, San Jose, California 95120 (United States); Harris, J. S. [Department of Electrical Engineering, Stanford University, Stanford, California 94305 (United States)

    2015-11-02

    Breaking time-reversal symmetry through magnetic doping of topological insulators has been identified as a key strategy for unlocking exotic physical states. Here, we report the growth of Bi{sub 2}Te{sub 3} thin films doped with the highest magnetic moment element Ho. Diffraction studies demonstrate high quality films for up to 21% Ho incorporation. Superconducting quantum interference device magnetometry reveals paramagnetism down to 2 K with an effective magnetic moment of ∼5 μ{sub B}/Ho. Angle-resolved photoemission spectroscopy shows that the topological surface state remains intact with Ho doping, consistent with the material's paramagnetic state. The large saturation moment achieved makes these films useful for incorporation into heterostructures, whereby magnetic order can be introduced via interfacial coupling.

  19. Search of fission products in 20Ne-ion beam interaction with 165Ho at 8 MeV/nucleon

    International Nuclear Information System (INIS)

    Singh, D.; Ali, R.; Afzal Ansari, M.; Rashid, M.H.

    2006-01-01

    In the present work, during the study complete fusion (CF) and incomplete fusion (ICF) in 20 Ne-induced reactions, the production cross-sections for several fission products in 20 Ne + 165 Ho system have been measured

  20. Influence of oil on flow condensation heat transfer of R410A inside 4.18 mm and 1.6 mm inner diameter horizontal smooth tubes

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Xiangchao; Ding, Guoliang; Hu, Haitao; Zhu, Yu.; Peng, Hao [Institute of Refrigeration and Cryogenics, Shanghai Jiaotong University, Shanghai 200240 (China); Gao, Yifeng [International Copper Association Shanghai Office, Shanghai 200020 (China); Deng, Bin [Institute of Heat Transfer Technology, Golden Dragon Precise Copper Tube Group Inc., Shanghai 200135 (China)

    2010-01-15

    The influence of oil on condensation heat transfer of R410A inside 4.18 mm and 1.6 mm inner diameter horizontal smooth tubes is investigated experimentally. The experimental condensing temperature is 40 C, and nominal oil concentration range is from 0% to 5%. The test results indicate that the presence of oil deteriorates the heat transfer, and the deterioration effect becomes obvious with the increase of oil concentration. At oil concentration of 5%, the heat transfer coefficient decreases by maximum 24.9% and 28.5% for 4.18 mm and 1.6 mm tubes, respectively. A new correlation for heat transfer coefficients of R410A-oil mixture flow condensation inside smooth tubes is proposed, which agrees with all the experimental data within a deviation of -30% {proportional_to} +20%. (author)

  1. Effects of calcium binding and of EDTA and CaEDTA on the clotting of bovine fibrinogen by thrombin.

    Science.gov (United States)

    Perizzolo, K E; Sullivan, S; Waugh, D F

    1985-03-01

    Studies were carried out at pH 7.0 and gamma/2 0.15 before addition of CaCl2 or EDTA. Clotting time, tau, at 3.03 microM fibrinogen and 0.91 u/ml thrombin was determined for equilibrium systems. With added Ca2+, tau decreases, from tau 0 at 0 added Ca2+ (mean, 29.7 +/- 3 s), by approximately 3 s at 5 mM added Ca2+. With added EDTA, tau increases sigmoidally from tau 0 at 0 EDTA to a maximum (mean tau m = 142 +/- 23 s) at approximately 200 microM EDTA. tau then decreases slightly to a minimum at approximately 1.3 mM and finally increases to infinity at approximately 10 mM EDTA. Between 0 and 1.3 mM EDTA, effects on clotting time are completely reversed by adding Ca2+ and, after equilibration at 400 microM EDTA, tau is independent of EDTA concentration. Thus, up to 400 microM EDTA, effects on clotting time are attributed to decreasing fibrinogen bound Ca2+. Between 5 mM Ca2+ and 200 microM EDTA it is assumed that an equilibrium distribution of fibrinogen species having 3, 2, 1, or 0 bound calcium ions is established and that a clotting time is determined by the sum of products of species fractional abundance and pure species clotting time. Analysis indicates that pure species clotting times increase proportionately with decreasing Ca2+ binding, binding sites are nearly independent, and the microscopic association constant for the first bound Ca2+ is approximately 4.9 X 10(6) M-1. Effects of adding Ca2+ at times t1 after thrombin addition to systems initially equilibrated at 200 microM EDTA were determined. Analysis of the relation between tau and t1 indicates that as Ca2+ binding decreases, rate constants for release of B peptides decrease less than those for release of A peptides. As EDTA concentration is increased above 1.3 mM, inhibitory effects of EDTA and CaEDTA progressively increase.

  2. Performance of ultra-small silicon photomultiplier array with active area of 0.12 mm×0.12 mm

    Energy Technology Data Exchange (ETDEWEB)

    Yue, Wang; Zongde, Chen; Chenhui, Li; Ran, He; Shenyuan, Wang; Baicheng, Li; Ruiheng, Wang; Kun, Liang, E-mail: lk@bnu.edu.cn; Ru, Yang; Dejun, Han

    2015-07-01

    We report the performance of an ultra-small silicon photomultiplier (SiPM) line array with 7 elements of 0.12×0.12 mm{sup 2} in active area, 0.2 mm in pitch and 120 micro cells in one element. The device features an epitaxial bulk quenching resistor concept, demonstrated high geometrical fill factor of 41% and photon detection efficiency (PDE) of 25.4% in the wavelength region between 430 nm and 480 nm while retaining high micro cell density around 10 000 mm{sup −2} and ~3 ns FWHM of dark pulses width; it also demonstrated dark count rate of less than 28.7 kHz, optical crosstalk of the order of 2% to 4%, and excellent photon number discrimination. A 0.15 mm×1.6 mm×1.6 mm lutetium yttrium oxyorthosilicate (LYSO) crystal, corresponding to the width, length and height respectively, was successfully coupled to the 1×7 SiPM array for possible ultra-highly resolved positron emission tomography (PET) applications. This novel type of device has advantages particularly for small active area since the performances, such as PDE and response speed is one of the best among SiPMs with similarly high density of micro cells. It may pave a way for this type of SiPM as a promising pixel position sensitive device in imaging sensor applications. - Highlights: • The ultra-small SiPM line array with active area of 0.12 mm×0.12 mm was presented. • The ultra-small SiPM employs the bulk silicon structure as quenching resistor. • A considerable dynamic range and PDE over 25.4% @ 430 nm to 480 nm were characterized.

  3. Lattice Dynamics of fcc Ca

    DEFF Research Database (Denmark)

    Stassis, C.; Zaretsky, J.; Misemer, D. K.;

    1983-01-01

    A large single crystal of FCC Ca was grown and was used to study the lattice dynamics of this divalent metal by coherent inelastic neutron scattering. The phonon dispersion curves were measured, at room temperature, along the [ξ00], [ξξ0], [ξξξ], and [0ξ1] symmetry directions. The dispersion curves...... to the propagation of elastic waves. The frequencies of the T1[ξξ0] branch for ξ between approximately 0.5 and 0.8 are slightly above the velocity-of-sound line determined from the low-frequency measurements. Since a similar effect has been observed in FCC Yb, it is natural to assume that the anomalous dispersion...... bear a striking resemblance to those of FCC Yb, which is also a divalent metal with an electronic band structure similar to that of Ca. In particular, the shear moduli c44 and (c11-c 12)/2 differ by a factor of 3.4, which implies that FCC Ca (like FCC Yb) is very anisotropic with regard...

  4. Lithium-induced inhibition of Na-K ATPase and Ca ATPase activities in rat brain synaptosome.

    Science.gov (United States)

    Cho, Y. W.

    1995-01-01

    To explore the action mechanism of lithium in the brain, the author investigated the effects of lithium on Na-K ATPase and Ca ATPase in rat brain synaptosomes prepared from forebrains by the method of Booth and Clark. The activities of Na-K ATPase and Ca ATPase were assayed by the level of inorganic phosphate liberated from the hydrolysis of ATP. Lithium at the optimum therapeutic concentration of 1 mM decreased the activity of Na-K ATPase from the control value of 19.08 +/- 0.29 to 18.27 +/- 0.10 micromoles Pi/mg protein/h and also reduced the activity of Ca ATPase from 6.38 +/- 0.12 to 5.64 +/- 0.12 micromoles Pi/mg protein/h. The decreased activity of Na-K ATPase will decrease the rate of Ca2+ efflux, probably via an Na-Ca exchange mechanism and will increase the rate of Ca2+ entry by the depolarization of nerve terminals. The reduced activity of Ca ATPase will result in the decreased efflux of Ca2+. As a Conclusion, it can be speculated that lithium elevates the intrasynaptosomal Ca2+ concentration via inhibition of the activities of Na-K ATPase and Ca ATPase, and this increased [Ca2+]i will cause the release of neurotransmitters and neurological effects of lithium. PMID:7598829

  5. Development and application of specially-focused ultrasonic transducers to location and sizing of defects in 75 mm- to 127 mm-thick austenitic stainless steel weld metals

    Energy Technology Data Exchange (ETDEWEB)

    Dalder, E.N.C.; Benson, S.; McKinley, B.J.; Carodiskey, T.

    1992-08-01

    Special UT transducer parts, capable of focusing incident signals within a 25 mm {times} 25 mm {times} 25 mm volume in an austenitic stainless weld metal at depths that varied from 25 mm to 127 mm, were developed and demonstrated to be capable of detecting a defect with cross section equivalent to that of a 4.76 mm-dia flat-bottom hole. Defect length sizing could be accomplished to {plus_minus}50% for 100% of the time and to {plus_minus}25% on selected defect types as follows: porosity groups, 100%; cracks, 67%; combined slag and porosity, 60%; and linear slag indications, 59%. Extensive linear elastic-fracture-mechanics analyses were performed to establish allowable defect sizes at functions of stress, based on a cyclic-life criterion of 10{sup 3} full power cycles of the MFTF-B magnet system. These defect sizes were used to determine which UT indicating were to be removed and repaired and which were to be retained and their recorded sizes and locations.

  6. Biomechanical comparison of 3.0 mm headless compression screw and 3.5 mm cortical bone screw in a canine humeral condylar fracture model.

    Science.gov (United States)

    Gonsalves, Mishka N; Jankovits, Daniel A; Huber, Michael L; Strom, Adam M; Garcia, Tanya C; Stover, Susan M

    2016-09-20

    To compare the biomechanical properties of simulated humeral condylar fractures reduced with one of two screw fixation methods: 3.0 mm headless compression screw (HCS) or 3.5 mm cortical bone screw (CBS) placed in lag fashion. Bilateral humeri were collected from nine canine cadavers. Standardized osteotomies were stabilized with 3.0 mm HCS in one limb and 3.5 mm CBS in the contralateral limb. Condylar fragments were loaded to walk, trot, and failure loads while measuring construct properties and condylar fragment motion. The 3.5 mm CBS-stabilized constructs were 36% stiffer than 3.0 mm HCS-stabilized constructs, but differences were not apparent in quality of fracture reduction nor in yield loads, which exceeded expected physiological loads during rehabilitation. Small residual fragment displacements were not different between CBS and HCS screws. Small fragment rotation was not significantly different between screws, but was weakly correlated with moment arm length (R² = 0.25). A CBS screw placed in lag fashion provides stiffer fixation than an HCS screw, although both screws provide similar anatomical reduction and yield strength to condylar fracture fixation in adult canine humeri.

  7. Optical properties of Mg2+, Yb3+, and Ho3+ tri-doped LiNbO3 crystals

    Science.gov (United States)

    Dai, Li; Liu, Chun-Rui; Tan, Chao; Yan, Zhe-Hua; Xu, Yu-Heng

    2017-04-01

    A series of LiNbO3 crystals tri-doped with Mg{}2+, Yb{}3+, and Ho{}3+ are grown by the conventional Czochraski technique. The concentrations of Mg{}2+, Yb{}3+, and Ho{}3+ ions in Mg:Yb:Ho:LiNbO3 crystals are measured by using an inductively coupled plasma atomic emission spectrometry. The x-ray diffraction is proposed to determine the lattice constant and analyze the internal structure of the crystal. The light-induced scattering of Mg:Yb:Ho:LiNbO3 crystal is quantitatively described via the threshold effect of incident exposure energy flux. The exposure energy ({E}{{r}}) is calculated to discuss the optical damage resistance ability. The exposure energy of Mg(7 mol):Yb:Ho:LiNbO3 crystal is 709.17 J/cm2, approximately 425 times higher than that of the Mg(1 mol):Yb:Ho:LiNbO3 crystal in magnitude. The blue, red, and very intense green bands of Mg:Yb:Ho:LiNbO3 crystal are observed under the 980-nm laser excitation to evaluate the up-conversion emission properties. The dependence of the emission intensity on pumping power indicates that the up-conversion emission is a two-photon process. The up-conversion emission mechanism is discussed in detail. This study indicates that Mg:Yb:Ho:LiNbO3 crystal can be applied to the fabrication of new multifunctional photoluminescence devices. Project supported by the National Natural Science Foundation of China (Grant No. 51301055), the Youth Science Fund of Heilongjiang Province, China (Grant No. QC2015061), the Special Funds of Harbin Innovation Talents in Science and Technology Research, China (Grant No. 2015RQQXJ045 ), and the Science Funds for the Young Innovative Talents of Harbin University of Science and Technology, China (Grant No. 201501).

  8. hHO-1 combined with GATA-4 transduction promotes myocardial transdifferentiation and anti- apoptosis of rat mesenchymal stem cells

    Directory of Open Access Journals (Sweden)

    Ning-bo DENG

    2017-06-01

    Full Text Available Objectives To explore if the rat bone marrow mesenchymal stem cells (BMSCs modified by human heme oxygenase 1 (hHO-1 gene combined with GATA-4 gene may promote the ability of anti-apoptosis and myocardial transdifferentiation in vitro in hypoxia ischemic environment. Methods The rat BMSCs were isolated and cultured by whole bone marrow adherence and identified in vitro, and then were transfected with recombinant adenovirus; Western blotting was used to determinate the optimal time of gene expression; the genetically modified BMSCs were taken to hypoxia serum-free conditions simulating ischemia hypoxia microenvironment in vivo; CCK-8 kit and trypan blue staining were performed to detect the 12, 24, 48 and 72h survival rates in hypoxia ischemia respectively; flow cytometry was used to detect the apoptosis of BMSCs in hypoxia ischemia for 24h. The cardiomyocyte-specific cardiac troponin I (cTnI was detected by Western blotting and cellular immunofluorescence. Results The 12, 24, 48 and 72h survival rates were higher in hHO-1+GATA-4 group cultured in ischemia and hypoxia condition than in hHO-1 group (P<0.05 and GATA-4 group (P<0.05. After 24h cultivation in ischemia hypoxia condition, the apoptotic rates were lower in hHO-1+GATA-4 group than in hHO-1 group (P<0.05 and GATA-4 group (P<0.05. No significant difference existed in cTnI expressions between GATA-4 group and hHO-1+GATA-4 group. Conclusion Compared with transfection of hHO-1 or GATA-4 single gene, hHO-1 combined with GATA-4 transduction can significantly increase the survival rate of BMSCs in hypoxia ischemic condition, but myocardial transdifferentiation does not increase significantly. DOI: 10.11855/j.issn.0577-7402.2017.04.08

  9. Kundalini Yoga, Yogi Tee und das Wassermannzeitalter: Bibliografische Einblicke in die Healthy, Happy, Holy Organization (3HO) des Yogi Bhajan

    OpenAIRE

    Laue, Thorsten

    2008-01-01

    Obwohl seit 40 Jahren im Westen aktiv, ist die Healthy, Happy, Holy Organization (3HO) des Yogi Bhajan (1929-2004) von der deutschen wie internationalen Forschung weitestgehend übersehen worden. Um dieser Forschungslücke entgegenzuwirken, verfasste ich 2003 meine religionswissenschaftlich begründete Magisterarbeit Darstellung und Quellen der 3HO Deutschland e.V. Aus dem Darstellungsteil entstand die 2007 im Münsteraner LIT-Verlag publizierte Monographie Kundalini Yoga, Yogi Tee und das Wasser...

  10. Investigation on Er{sup 3+}/Ho{sup 3+} co-doped silicate glass for ~2 µm fiber lasers

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xueqiang; Huang, Feifei; Cheng, Jimeng; Fan, Xiaokang; Gao, Song [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China); Graduate School of Chinese Academy of Science, Beijing 100039 (China); Zhang, Junjie [College of Materials Science and Technology, China Jiliang University, Hangzhou 310018 (China); Hu, Lili [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China); Chen, Danping, E-mail: dpchen2008@aliyun.com [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China)

    2015-06-15

    A stable Er{sup 3+}/Ho{sup 3+} co-doped lead silicate glass is developed. Luminescent properties are recorded under pumping with 808 and 1550 nm lasers. Energy-transfer mechanism and efficiency are analyzed. Energy-transfer efficiency from Er{sup 3+}:{sup 4}I{sub 13/2} to Ho{sup 3+}:{sup 5}I{sub 7} reaches 93.8% at 3 mol% Ho{sub 2}O{sub 3} doping concentration. Strong luminescence is detected when pumped at 1550 nm because of efficient energy transfer from Er{sup 3+}:{sup 4}I{sub 13/2} to Ho{sup 3+}:{sup 5}I{sub 7}. Peak gain coefficient at 2056 nm is detected as 1.62 cm{sup −1}. The excellent luminescent property and high stability indicate that Er{sup 3+}/Ho{sup 3+} co-doped lead silicate glass can be applied in 2 µm fiber lasers. - Highlights: • Er{sup 3+}/Ho{sup 3+} co-doped silicate glasses with high stability are prepared. • Strong luminescence is detected under pump of 1550 nm lasers owing to efficient energy transfer from Er{sup 3+} to Ho{sup 3+}. • Transfer efficiency is calculated to be 93.8% when Ho{sub 2}O{sub 3} doping concentration is up to 3 mol%. • Gain coefficient peaks at 2056 nm to be 1.62 cm{sup −1}.

  11. Magnetic phase transitions and large magnetic entropy change with a wide temperature span in HoZn

    Energy Technology Data Exchange (ETDEWEB)

    Li, Lingwei, E-mail: wei0396@hotmail.com [Key Laboratory of Electromagnetic Processing of Materials (Ministry of Education), Northeastern University, Shenyang 110819 (China); Institut für Anorganische und Analytische Chemie, Universität Münster, Corrensstrasse 30, D-48149 Münster (Germany); Yuan, Ye [Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Ion Beam Physics and Materials Research, P.O. Box 510119, 01314 Dresden (Germany); Zhang, Yikun [Key Laboratory of Electromagnetic Processing of Materials (Ministry of Education), Northeastern University, Shenyang 110819 (China); Pöttgen, Rainer [Institut für Anorganische und Analytische Chemie, Universität Münster, Corrensstrasse 30, D-48149 Münster (Germany); Zhou, Shengqiang [Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Ion Beam Physics and Materials Research, P.O. Box 510119, 01314 Dresden (Germany)

    2015-09-15

    Highlights: • Magnetic phase transitions and magnetocaloric effect in HoZn were studied. • The critical properties of HoZn were systematically investigated. • The obtained critical exponents are satisfied with scaling theory. • A large reversible magnetocaloric effect in HoZn was observed. • HoZn could be a promising candidate for magnetic refrigeration. - Abstract: CsCl-type HoZn undergoes two successive magnetic phase transitions: (i) paramagnetic to ferromagnetic (FM) at T{sub C} ∼ 72 K and (ii) a spin reorientation (SR) at T{sub SR} ∼ 26 K. Magnetization and modified Arrott plots indicate that HoZn undergoes a second-order magnetic phase transition around T{sub C}. The obtained critical exponents have some small deviations from the mean-field theory, indicating a short range or a local magnetic interaction which is properly related to the coexistence of FM and SR transitions at low temperature. Two successive magnetic transitions in HoZn induce one broad pronounced peak together with a shoulder in the temperature dependence of the magnetic entropy change −ΔS{sub M}(T) curves, resulting in a wide temperature range with a large relative cooling power (RCP). For a field change of 0–7 T, the maximum value of −ΔS{sub M} is 15.2 J/kg K around T{sub C} with a large RCP value of 1124 J/kg. The large reversible magnetocaloric effect (MCE) and RC indicate that HoZn is a good candidate for active magnetic refrigeration.

  12. Observation of a reorientation of the holmium moments in HoAl2 with polarized neutron diffraction

    International Nuclear Information System (INIS)

    Barbara, B.; Boucherle, J.X.; Rossignol, M.F.; Schweizer, J.

    1976-01-01

    Magnetization measurements performed on a single crystal of HoAl 2 show that the easy axis of magnetization is [110] at low temperature and suggest near 20 0 K a rotation of the easy direction of magnetization. This rotation has been strikingly demonstrated by polarized neutron diffraction experiments including measurements of intensities with both spin states and of depolarization through the sample. This result allows the interpretation of the magnetic properties of HoAl 2 in terms of crystal field

  13. Beam delivery system for Ho:YLF and applications in endodontics; Sistema de entrega de feixe para laser de Ho:YLF e aplicacoes em endodontia

    Energy Technology Data Exchange (ETDEWEB)

    Bachmann, Luciano

    2000-07-01

    The beam delivery systems, whether using fibers or articulated arms, are very important for the expansion of laser applications into life sciences. This work aims to couple an optical fiber to a home-made Er:Tm:Ho:LiYF{sub 4} laser. For this purpose the beam profile was studied using the beam quality factor M{sup 2} to achieve an homogeneous beam. To determine the M{sup 2} factor, the knife-edge technique was used, relating the laser energy eclipsed by the knife with its transversal position. The resonant cavity was made suitable in order to obtain a stable and homogeneous transversal beam profile, for the optical fiber coupling. It was used a 365 {mu}m diameter core low OH{sup -} content fused silica optical fiber, with a proximal SMA-905 connection and a flat distal end. M{sup 2} factors for the Ho:YLF were between 3 and 8, with a non astigmatic beam, although it was observed a divergence asymmetry in the transversal sections. The coupling efficiency was 96%, and in a repeated operation without any adjustment, the new coupling were 82% and 81%. Lasers have being recently used as an adjunct to conventional endodontic preparation to reduce intracanal microbial, preventing reinfection. The knowledge of thermal profile in endodontic procedures is important to determine laser irradiation conditions avoiding periodontal damages. In this sense, the second scope of this work was to use the Ho:YLF system to register the thermal profile in vitro and to compare the results with those obtained with Nd:YAG and Er:YAG commercial lasers. The temperature was recorded in real time through a thermocouple probe at the root apex , resulting in maximum increase of 7 deg C. (author)

  14. Mitochondrial Ca2+ influx and efflux rates in guinea pig cardiac mitochondria: low and high affinity effects of cyclosporine A.

    Science.gov (United States)

    Wei, An-Chi; Liu, Ting; Cortassa, Sonia; Winslow, Raimond L; O'Rourke, Brian

    2011-07-01

    Ca(2+) plays a central role in energy supply and demand matching in cardiomyocytes by transmitting changes in excitation-contraction coupling to mitochondrial oxidative phosphorylation. Matrix Ca(2+) is controlled primarily by the mitochondrial Ca(2+) uniporter and the mitochondrial Na(+)/Ca(2+) exchanger, influencing NADH production through Ca(2+)-sensitive dehydrogenases in the Krebs cycle. In addition to the well-accepted role of the Ca(2+)-triggered mitochondrial permeability transition pore in cell death, it has been proposed that the permeability transition pore might also contribute to physiological mitochondrial Ca(2+) release. Here we selectively measure Ca(2+) influx rate through the mitochondrial Ca(2+) uniporter and Ca(2+) efflux rates through Na(+)-dependent and Na(+)-independent pathways in isolated guinea pig heart mitochondria in the presence or absence of inhibitors of mitochondrial Na(+)/Ca(2+) exchanger (CGP 37157) or the permeability transition pore (cyclosporine A). cyclosporine A suppressed the negative bioenergetic consequences (ΔΨ(m) loss, Ca(2+) release, NADH oxidation, swelling) of high extramitochondrial Ca(2+) additions, allowing mitochondria to tolerate total mitochondrial Ca(2+) loads of >400nmol/mg protein. For Ca(2+) pulses up to 15μM, Na(+)-independent Ca(2+) efflux through the permeability transition pore accounted for ~5% of the total Ca(2+) efflux rate compared to that mediated by the mitochondrial Na(+)/Ca(2+) exchanger (in 5mM Na(+)). Unexpectedly, we also observed that cyclosporine A inhibited mitochondrial Na(+)/Ca(2+) exchanger-mediated Ca(2+) efflux at higher concentrations (IC(50)=2μM) than those required to inhibit the permeability transition pore, with a maximal inhibition of ~40% at 10μM cyclosporine A, while having no effect on the mitochondrial Ca(2+) uniporter. The results suggest a possible alternative mechanism by which cyclosporine A could affect mitochondrial Ca(2+) load in cardiomyocytes, potentially

  15. An inter-comparison of HO2 measured by Fluorescence Assay by Gas Expansion and Cavity Ringdown Spectroscopy in the Highly Instrumented Reactor for Atmospheric Chemistry.

    Science.gov (United States)

    Brennan, A.; Onel, L. C.; Gianella, M.; Ronnie, G.; Aguila, A. L.; Hancock, G.; Whalley, L.; Seakins, P. W.; Ritchie, G.; Heard, D. E.

    2017-12-01

    HO2 is an important species in the atmosphere, as it is involved in the HOx radical reaction cycle that is critical to the oxidation of atmospheric pollutants and the ultimate cleaning of the troposphere. One of the most widely utilised methods to measure HO2 is Fluorescence Assay by Gas Expansion (FAGE), which indirectly measures HO2 by sampling into a low pressure cell and titrating HO2 with NO to produce OH that is then detected by Laser Induced Fluorescence. This is an indirect and non-absolute detection technique that requires careful calibration to convert the measured signal into [HO2], which involves the photolysis of H2O at 185 nm to produce OH and HO2, and is subject to 30 % errors at 2σ level. The work presented here shows the validation of the FAGE technique and its calibration procedure through inter-comparison experiments between the non-absolute FAGE technique and Cavity Ringdown Spectroscopy (CRDS), an absolute absorption based method. The CRDS system was used to excite the first O-H overtone of the HO2 absorption band at 1506.43 nm, and features a cavity length of 1.2 m and a total path of 60 km. The experiments were performed inside the 2.25 m3 stainless steel Highly Instrumented Reactor for Atmospheric Chemistry (HIRAC), using a synthetic air mixture at 150 and 1000 mbar of pressure and 298 K. HO2 was generated by photolysis of Cl2 at 365 nm in the presence of CH3OH and O2, and the [HO2] was monitored using both instruments. Additionally, monitoring the temporal decay of HO2 during its self-reaction provided an alternative calibration method for the FAGE instrument, and allowed the absorption cross section of HO2 at 1506.43 nm, σHO2, to be measured. FAGE calibration factors determined through the second order decays of HO2 at 1000 mbar agreed within 8 % of the H2O photolysis method, and determinations of σHO2 at 150 and 1000 mbar agree with previously reported data within 20 % and 12 % respectively. [HO2] correlation plots between the two

  16. Development of Thermoluminescence Dosimeter CaSO4:Dy as Personal and Environmental Dosimeters

    International Nuclear Information System (INIS)

    Hasnel Sofyan

    2009-01-01

    Development of personal and environmental dosimeters using material phosphors of CaSO 4 :Dy powder in form capillary glass and disc teflon thermoluminescence (TL) dosimeter have been done. TL dosimeter CaSO 4 :Dy powder used can record dose response less than 0.01 mGy. Fading of TL dosimeter capillary glass after 29 days is 25%. In 1 batch, making of CaSO 4 :Dy powder can obtain 2 groups of dosimeter capillaries with coefficient variance smaller than 10%. This discrepancy caused difference in powder making and reading of the TL dosimeter. TL dosimeter CaSO 4 :Dy teflon disc with dia. 5 mm and 0.8 mm thickness is homogeneous mixture between phosphor powder with dia. 80 to 150 mesh and teflon powder dia. 20 μm. The composition of CaSO 4 :Dy and teflon in TL dosimeter influence sensitivity of the dosimeter. It’ concluded that in order to obtain optimal sensitivity of TL dosimeter, the composition of CaSO 4 :Dy and teflon is 3 and 1 with pressured of disc in 700 MPa. (author).

  17. Inhibitory effect of leptin on rosiglitazone-induced differentiation of primary adipocytes prepared from TallyHO/Jng mice

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ki Young; Kim, Joo Young; Sung, Yoon-Young; Jung, Won Hoon; Kim, Hee-Youn; Park, Ji Seon; Cheon, Hyae Gyeong [Medicinal Science Division, Korea Research Institute of Chemical Technology, 100 Jang-dong, Yuseong, 305-600 Daejon (Korea, Republic of); Rhee, Sang Dal, E-mail: sdrhee@krict.re.kr [Medicinal Science Division, Korea Research Institute of Chemical Technology, 100 Jang-dong, Yuseong, 305-600 Daejon (Korea, Republic of)

    2011-03-25

    Research highlights: {yields} In this study, we investigated the effects of leptin on adipocyte differentiation prepared from subcutaneous fat of TallyHo mice. {yields} Leptin inhibited the adipocytes differentiation at physiological concentration via inhibition of PPAR{gamma} expression. {yields} Inhibitors of ERK and STAT1 restored the leptin's inhibitory activity both in vitro and in vivo. -- Abstract: The effects of leptin on rosiglitazone-induced adipocyte differentiation were investigated in the primary adipocytes prepared from subcutaneous fat of TallyHO/Jng (TallyHO) mouse, a recently developed model animal for type 2 diabetes mellitus (T2DM). The treatment of leptin inhibited the rosiglitazone-induced adipocyte differentiation with a decreased expression of peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}) a key adipogenic transcription factor, both in mRNA and protein levels. Leptin (10 nM) was sufficient to inhibit the adipocyte differentiation, which seemed to come from increased expression of leptin receptor genes in the fat of TallyHO mice. The inhibition of adipogenesis by leptin was restored by the treatment of inhibitors for extracellular-signal-regulated kinase (ERK) (PD98059) and signal transducer and activator of transcription-1 (STAT1) (fludarabine). Furthermore, in vivo intraperitoneal administration of PD98059 and fludarabine increased the PPAR{gamma} expression in the subcutaneous fat of TallyHO mice. These data suggest that leptin could inhibit the PPAR{gamma} expression and adipocyte differentiation in its physiological concentration in TallyHO mice.

  18. Návrh Rail-to-Rail operačního zesilovače v technologii CMOS

    OpenAIRE

    Cvešper, Stanislav

    2016-01-01

    Práce se zabývá návrhem rail-to-rail operačního zesilovače ve třídě AB v technologii CMOS I3T25. Práce začíná úvodem do CMOS tranzistorů, následuje rozbor struktur operačního zesilovače, jeho návrh a simulace v návrhovém prostředí Cadence, popsány jsou také různé metody pro minimalizaci napěťové symetrie. Hlavním cílem práce je dosažení rail-to-rail vstupního i výstupního rozsahu operačního zesilovače pracujícího ve třídě AB, s minimální napěťovou nesymetrií, včetně návrhu topologie navrženéh...

  19. Genomic and antigenic relationships between two 'HoBi'-like strains and other members of the Pestivirus genus.

    Science.gov (United States)

    Mósena, Ana Cristina S; Cibulski, Samuel P; Weber, Matheus N; Silveira, Simone; Silva, Mariana S; Mayer, Fabiana Q; Roehe, Paulo M; Canal, Cláudio W

    2017-10-01

    'HoBi'-like viruses comprise a putative new species within the genus Pestivirus of the family Flaviviridae. 'HoBi'-like viruses have been detected worldwide in batches of fetal calf serum, in surveillance programs for bovine pestiviruses and from animals presenting clinical signs resembling bovine viral diarrhea virus (BVDV)-associated diseases. To date, few complete genome sequences of 'HoBi'-like viruses are available in public databases. Moreover, detailed analyses of such genomes are still scarce. In an attempt to expand data on the genetic diversity and biology of pestiviruses, two genomes of 'HoBi'-like viruses recovered from Brazilian cattle were described and characterized in this study. Analysis of the whole genome and antigenic properties of these two new 'HoBi'-like isolates suggest that these viruses are genetically close to recognized pestiviruses. The present data provide evidence that 'HoBi'-like viruses are members of the genus Pestivirus and should be formally recognized as a novel species.

  20. Purification of a 166mHo solution by successive high-performance liquid chromatography and gravitational chromatography for half-life determination

    International Nuclear Information System (INIS)

    Florence Gueguen; Helene Isnard; Carole Bresson; Celine Caussignac; Guillaume Stadelmann; Anthony Nonell; Sebastien Mialle; Karsten Kossert; Frederic Chartier

    2014-01-01

    A methodology to purify a 166m Ho solution has been developed by a combination of activity and mass concentration measurements in order to further determine the 166m Ho half-life. The isobaric interference at m/q ≃ 166 requires Ho purification from non-natural Er with a high purification degree due to the large amount of Ho as opposed to Er. The Ho/Er separation was achieved using high-performance liquid chromatography on a semi-preparative column followed by purification on gravitational chromatography. The efficiency of the separation was evaluated after precise determination of the Er isotopic composition. The purification methodology enabled to separate Ho from Er. (author)