Sample records for mission viii corot-7b

  1. Transiting exoplanets from the CoRoT space mission. VIII. CoRoT-7b: the first super-Earth with measured radius (United States)

    Léger, A.; Rouan, D.; Schneider, J.; Barge, P.; Fridlund, M.; Samuel, B.; Ollivier, M.; Guenther, E.; Deleuil, M.; Deeg, H. J.; Auvergne, M.; Alonso, R.; Aigrain, S.; Alapini, A.; Almenara, J. M.; Baglin, A.; Barbieri, M.; Bruntt, H.; Bordé, P.; Bouchy, F.; Cabrera, J.; Catala, C.; Carone, L.; Carpano, S.; Csizmadia, Sz.; Dvorak, R.; Erikson, A.; Ferraz-Mello, S.; Foing, B.; Fressin, F.; Gandolfi, D.; Gillon, M.; Gondoin, Ph.; Grasset, O.; Guillot, T.; Hatzes, A.; Hébrard, G.; Jorda, L.; Lammer, H.; Llebaria, A.; Loeillet, B.; Mayor, M.; Mazeh, T.; Moutou, C.; Pätzold, M.; Pont, F.; Queloz, D.; Rauer, H.; Renner, S.; Samadi, R.; Shporer, A.; Sotin, Ch.; Tingley, B.; Wuchterl, G.; Adda, M.; Agogu, P.; Appourchaux, T.; Ballans, H.; Baron, P.; Beaufort, T.; Bellenger, R.; Berlin, R.; Bernardi, P.; Blouin, D.; Baudin, F.; Bodin, P.; Boisnard, L.; Boit, L.; Bonneau, F.; Borzeix, S.; Briet, R.; Buey, J.-T.; Butler, B.; Cailleau, D.; Cautain, R.; Chabaud, P.-Y.; Chaintreuil, S.; Chiavassa, F.; Costes, V.; Cuna Parrho, V.; de Oliveira Fialho, F.; Decaudin, M.; Defise, J.-M.; Djalal, S.; Epstein, G.; Exil, G.-E.; Fauré, C.; Fenouillet, T.; Gaboriaud, A.; Gallic, A.; Gamet, P.; Gavalda, P.; Grolleau, E.; Gruneisen, R.; Gueguen, L.; Guis, V.; Guivarc'h, V.; Guterman, P.; Hallouard, D.; Hasiba, J.; Heuripeau, F.; Huntzinger, G.; Hustaix, H.; Imad, C.; Imbert, C.; Johlander, B.; Jouret, M.; Journoud, P.; Karioty, F.; Kerjean, L.; Lafaille, V.; Lafond, L.; Lam-Trong, T.; Landiech, P.; Lapeyrere, V.; Larqué, T.; Laudet, P.; Lautier, N.; Lecann, H.; Lefevre, L.; Leruyet, B.; Levacher, P.; Magnan, A.; Mazy, E.; Mertens, F.; Mesnager, J.-M.; Meunier, J.-C.; Michel, J.-P.; Monjoin, W.; Naudet, D.; Nguyen-Kim, K.; Orcesi, J.-L.; Ottacher, H.; Perez, R.; Peter, G.; Plasson, P.; Plesseria, J.-Y.; Pontet, B.; Pradines, A.; Quentin, C.; Reynaud, J.-L.; Rolland, G.; Rollenhagen, F.; Romagnan, R.; Russ, N.; Schmidt, R.; Schwartz, N.; Sebbag, I.; Sedes, G.; Smit, H.; Steller, M. B.; Sunter, W.; Surace, C.; Tello, M.; Tiphène, D.; Toulouse, P.; Ulmer, B.; Vandermarcq, O.; Vergnault, E.; Vuillemin, A.; Zanatta, P.


    Aims: We report the discovery of very shallow (Δ F/F ≈ 3.4× 10-4), periodic dips in the light curve of an active V = 11.7 G9V star observed by the CoRoT satellite, which we interpret as caused by a transiting companion. We describe the 3-colour CoRoT data and complementary ground-based observations that support the planetary nature of the companion. Methods: We used CoRoT colours information, good angular resolution ground-based photometric observations in- and out- of transit, adaptive optics imaging, near-infrared spectroscopy, and preliminary results from radial velocity measurements, to test the diluted eclipsing binary scenarios. The parameters of the host star were derived from optical spectra, which were then combined with the CoRoT light curve to derive parameters of the companion. Results: We examined all conceivable cases of false positives carefully, and all the tests support the planetary hypothesis. Blends with separation >0.40´´or triple systems are almost excluded with a 8 × 10-4 risk left. We conclude that, inasmuch we have been exhaustive, we have discovered a planetary companion, named CoRoT-7b, for which we derive a period of 0.853 59 ± 3 × 10-5 day and a radius of Rp = 1.68 ± 0.09 R_Earth. Analysis of preliminary radial velocity data yields an upper limit of 21 M_Earth for the companion mass, supporting the finding. Conclusions: CoRoT-7b is very likely the first Super-Earth with a measured radius. This object illustrates what will probably become a common situation with missions such as Kepler, namely the need to establish the planetary origin of transits in the absence of a firm radial velocity detection and mass measurement. The composition of CoRoT-7b remains loosely constrained without a precise mass. A very high surface temperature on its irradiated face, ≈1800-2600 K at the substellar point, and a very low one, ≈50 K, on its dark face assuming no atmosphere, have been derived. The CoRoT space mission, launched on 27

  2. The expected interior and surface environment of CoRoT-7b (United States)

    Ziethe, R.; Wurz, P.; Lammer, H.


    The discovery of extrasolar planets - planets that orbit stars other than our sun - has always been fascinating. Meanwhile more than 400 so--called exoplanets have been detected. However, most of the detected exoplanets so far are relatively large (beyond 10 Earth masses) and can be regarded as gaseous planets, but scientists have always seeked after smaller and rocky planets, which could be compared to Earth or other earth--like bodies. Recently, the COROT mission discovered an object, Corot-7b, with a radius of only 1.68 REarth corresponding to a mass of 4.8 +/- 0.8 MEarth. This first low-mass exoplanet -- a so-called Super-Earth -- can be considered to be solid. Corot-7b orbits its primary at a very close distance and is therefore tidally locked in an 1:1 spin-orbit resonance. This implies a very inhomogeneous energy input from the star into the planet. Since the dayside is constantly exposed to the star, there is a strong temperature gradient towards the nightside. The surface temperature on the illuminated side is estimated with 2700K, while the shadowed side is thought to be at 110K. The high temperatures on the dayside will cause the evaporation of volatiles, which gives rise to the formation of an atmosphere. We introduce a three dimensional thermal convection model by solving the pertaining dimensionless hydrodynamical equations, computing the temperature field and especially investigate the formation of partially molten regions due to the inhomogeneous energy input onto the surface. The temperature of the surface and subsurface regions is enormously important for the composition of the atmosphere fed from volatiles, which escaped from the planet. The atmosphere is the only part of this exoplanet, which can be observed with remote sensing methods. Henceforth, understanding the conditions for the formation of an atmosphere (i.e., surface temperature map) is an important step forward in understanding extrasolar planets. We found that the highest temperatures

  3. The Roles of Tidal Evolution and Evaporative Mass Loss in the Origin of CoRoT-7 b (United States)

    Jackson, Brian; Miller, Neil; Barnes, Rory; Raymond, Sean N.; Fortney, Jonathan J.; Greenberg, Richard


    CoRoT-7 b is the first confirmed rocky exoplanet, but, with an orbital semimajor axis of 0.0172 au, its origins may be unlike any rocky planet in our Solar System. In this study, we consider the roles of tidal evolution and evaporative mass loss in CoRoT-7 b's history, which together have modified the planet's mass and orbit. If CoRoT-7 b has always been a rocky body, evaporation may have driven off almost half its original mass, but the mass loss may depend sensitively on the extent of tidal decay of its orbit. As tides caused CoRoT-7 b's orbit to decay, they brought the planet closer to its host star, thereby enhancing the mass loss rate. Such a large mass loss also suggests the possibility that CoRoT-7 b began as a gas giant planet and had its original atmosphere completely evaporated. In this case, we find that CoRoT-7 b's original mass probably did not exceed 200 Earth masses (about two-third of a Jupiter mass). Tides raised on the host star by the planet may have significantly reduced the orbital semimajor axis, perhaps causing the planet to migrate through mean-motion resonances with the other planet in the system, CoRoT-7 c. The coupling between tidal evolution and mass loss may be important not only for CoRoT-7 b but also for other close-in exoplanets, and future studies of mass loss and orbital evolution may provide insight into the origin and fate of close-in planets, both rocky and gaseous.

  4. Modeling of exoplanets interiors in the framework of future space missions (United States)

    Brugger, B.; Mousis, O.; Deleuil, M.


    Probing the interior of exoplanets with known masses and radii is possible via the use of models of internal structure. Here we present a model able to handle various planetary compositions, from terrestrial bodies to ocean worlds or carbon-rich planets, and its application to the case of CoRoT-7b. Using the elemental abundances of an exoplanet’s host star, we significantly reduce the degeneracy limiting such models. This further constrains the type and state of material present at the surface, and helps estimating the composition of a secondary atmosphere that could form in these conditions through potential outgassing. Upcoming space missions dedicated to exoplanet characterization, such as PLATO, will provide accurate fundamental parameters of Earth-like planets orbiting in the habitable zone, for which our model is well adapted.

  5. Factor VIII assay (United States)

    ... this page: // Factor VIII assay To use the sharing features on ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health ...

  6. Blood coagulation factor VIII

    Indian Academy of Sciences (India)

    Factor VIII (FVIII) functions as a co-factor in the blood coagulation cascade for the proteolytic activation of factor X by factor IXa. Deficiency of FVIII causes hemophilia A, the most commonly inherited bleeding disorder. This review highlights current knowledge on selected aspects of FVIII in which both the scientist and the ...

  7. The vestibulocochlear nerve (VIII). (United States)

    Benoudiba, F; Toulgoat, F; Sarrazin, J-L


    The vestibulocochlear nerve (8th cranial nerve) is a sensory nerve. It is made up of two nerves, the cochlear, which transmits sound and the vestibular which controls balance. It is an intracranial nerve which runs from the sensory receptors in the internal ear to the brain stem nuclei and finally to the auditory areas: the post-central gyrus and superior temporal auditory cortex. The most common lesions responsible for damage to VIII are vestibular Schwannomas. This report reviews the anatomy and various investigations of the nerve. Copyright © 2013. Published by Elsevier Masson SAS.

  8. Structural Instability in Ice VIII under Pressure

    International Nuclear Information System (INIS)

    Besson, J.; Klotz, S.; Hamel, G.; Marshall, W.; Nelmes, R.; Loveday, J.


    Below 125K, tetragonal ice VIII remains in a metastable form at ambient pressure. This form has long been considered to be identical to ice VIII, although unexplained discrepancies exist between their vibrational spectra. Neutron diffraction studies reveal an isostructural phase transformation below 2GPa related to a weakening of the bonds between the two D 2 O sublattices of ice VIII. In this new phase, ice VIII ' , the tetragonal distortion is 20% larger than in ice VIII, which accounts for the differences between the vibrational frequencies of the two phases. copyright 1997 The American Physical Society

  9. 77 FR 64401 - Order of Succession for HUD Region VIII (United States)


    ... Region VIII AGENCY: Office of Field Policy and Management, HUD. ACTION: Notice of Order of Succession... Field Offices (Region VIII). This Order of Succession supersedes all previous Orders of Succession for HUD Region VIII. DATES: Effective Date: October 9, 2012. FOR FURTHER INFORMATION CONTACT: Lawrence D...

  10. [Ehler-Danlos syndrome type VIII]. (United States)

    Ciarloni, L; Perrigouard, C; Lipsker, D; Cribier, B


    Ehlers-Danlos syndrome (EDS) comprises a heterogeneous group of diseases involving genetic collagen fibre impairment. We describe a case of a patient presenting the rare type VIII, in which dermatitis ocre was associated with parodontal disease, and which was diagnosed late. A 29-year-old man consulted for a pretibial ulcer present for seven years, resulting from a post-traumatic haematoma that had failed to heal. In view of the longiliner morphology, it had previously been diagnosed as Marfan syndrome. Subsequently, edentation was observed as well as "alveolar bone fragility". Examination revealed a marfanoid morphotype, a pretibial ulcer set within long-standing bilateral dermatitis ocre and papyraceous scars, but no joint hyperlaxity or cutaneous hyperelasticity. The diagnosis was consequently corrected to EDS type VIII. Type VIII is a rare form of EDS, and the molecular mechanism is poorly understood. The involvement of parodontal connective tissue suggests impairment of collagen I and III proteins. It is important to identify this type of the disease since it involves parodontal disease for which early treatment is required in order to try to prevent edentation. The present case demonstrates the importance of diagnosis, which may be based upon appearance of bilateral dermatitis ocre from the age of 15 years associated with skin fragility. This sign is not part of the classical picture of Marfan syndrome, with which EDS type VIII is often confounded. Copyright 2009 Elsevier Masson SAS. All rights reserved.

  11. Development and characterization of recombinant ovine coagulation factor VIII.

    Directory of Open Access Journals (Sweden)

    Philip M Zakas

    Full Text Available Animal models of the bleeding disorder, hemophilia A, have been an integral component of the biopharmaceutical development process and have facilitated the development of recombinant coagulation factor VIII (fVIII products capable of restoring median survival of persons with hemophilia A to that of the general population. However, there remain several limitations to recombinant fVIII as a biotherapeutic, including invasiveness of intravenous infusion, short half-life, immunogenicity, and lack of availability to the majority of the world's population. The recently described ovine model of hemophilia A is the largest and most accurate phenocopy. Affected sheep die prematurely due to bleeding-related pathogenesis and display robust adaptive humoral immunity to non-ovine fVIII. Herein, we describe the development and characterization of recombinant ovine fVIII (ofVIII to support further the utility of the ovine hemophilia A model. Full-length and B-domain deleted (BDD ofVIII cDNAs were generated and demonstrated to facilitate greater biosynthetic rates than their human fVIII counterparts while both BDD constructs showed greater expression rates than the same-species full-length versions. A top recombinant BDD ofVIII producing baby hamster kidney clone was identified and used to biosynthesize raw material for purification and biochemical characterization. Highly purified recombinant BDD ofVIII preparations possess a specific activity nearly 2-fold higher than recombinant BDD human fVIII and display a differential glycosylation pattern. However, binding to the carrier protein, von Willebrand factor, which is critical for stability of fVIII in circulation, is indistinguishable. Decay of thrombin-activated ofVIIIa is 2-fold slower than human fVIII indicating greater intrinsic stability. Furthermore, intravenous administration of ofVIII effectively reverses the bleeding phenotype in the murine model of hemophilia A. Recombinant ofVIII should facilitate

  12. The influence of prophylactic factor VIII in severe hemophilia A (United States)

    Gissel, Matthew; Whelihan, Matthew F; Ferris, Lauren A; Mann, Kenneth G; Rivard, Georges E; Brummel-Ziedins, Kathleen E


    Introduction Hemophilia A individuals displaying a similar genetic defect have heterogeneous clinical phenotypes. Aim To evaluate the underlying effect of exogenous factor (f)VIII on tissue factor (Tf)-initiated blood coagulation in severe hemophilia utilizing both empirical and computational models. Methods We investigated twenty-five clinically severe hemophilia A patients. All individuals were on fVIII prophylaxis and had not received fVIII from 0.25 to 4 days prior to phlebotomy. Coagulation was initiated by the addition of Tf to contact-pathway inhibited whole blood ± an anti-fVIII antibody. Aliquots were quenched over 20 min and analyzed for thrombin generation and fibrin formation. Coagulation factor levels were obtained and used to computationally predict thrombin generation with fVIII set to either zero or its value at the time of the draw. Results Due to prophylactic fVIII, at the time of the blood draw, the individuals had fVIII levels that ranged from hemophilia A. The combination of each individual's coagulation factors (outside of fVIII) determine each individual's baseline thrombin potential and may affect bleeding risk. PMID:21899664

  13. The labour ward analgesic service at King Edward VIII Hospital ...

    African Journals Online (AJOL)

    The labour ward analgesic service at King Edward VIII. Hospital, Durban. D. A. ROCKE, C. C. ROUT, H. D. RUSSELL, S. SINGH. Abstract The provision of analgesic services to the labour ward at King Edward VIII Hospital was studied during a I-week period. Of249 patients, 113 (45%) received no analgesia whatsoever.

  14. One-electron spectrum of Xe VIII

    International Nuclear Information System (INIS)

    Roberts, J.R.; Knystautas, E.J.; Sugar, J.


    The spectrum of Xe VIII has been observed in a theta-pinch discharge. New line identifications were made that determine the energies of the 6s, 7s, 6p, and 5f terms relative to the 5s 2 S ground state and confirm the previously known 5p and 5d terms. An independent system of levels derived from the observed 4f-ng (n = 5,6) transitions was found. Its position relative to the ground state is obtained from a predicted value for the 5g effective quantum number n*. From the ns series (n=5--7) a value for the ionization enegy of 105.91 +- 0.05 eV was derived

  15. VIII International Meeting on Lorentzian Geometry

    CERN Document Server

    Flores, José; Palomo, Francisco; GeLoMa 2016; Lorentzian geometry and related topics


    This volume contains a collection of research papers and useful surveys by experts in the field which provide a representative picture of the current status of this fascinating area. Based on contributions from the VIII International Meeting on Lorentzian Geometry, held at the University of Málaga, Spain, this volume covers topics such as distinguished (maximal, trapped, null, spacelike, constant mean curvature, umbilical...) submanifolds, causal completion of spacetimes, stationary regions and horizons in spacetimes, solitons in semi-Riemannian manifolds, relation between Lorentzian and Finslerian geometries and the oscillator spacetime. In the last decades Lorentzian geometry has experienced a significant impulse, which has transformed it from just a mathematical tool for general relativity to a consolidated branch of differential geometry, interesting in and of itself. Nowadays, this field provides a framework where many different mathematical techniques arise with applications to multiple parts of mathem...

  16. VIII Brazilian Meeting on Simulational Physics (BMSP)

    International Nuclear Information System (INIS)

    Branco, N. S.; Figueiredo, W.; Plascak, J. A.; Santos, M.


    This special issue includes invited and selected articles of the VIII Brazilian Meeting on Simulational Physics (BMSP), held in Florianópolis, Santa Catarina, Brazil, from 3rd to 8th August, 2015. This is the eighth such meeting, and the second one to have contributed papers published in Journal of Physics: Conference Series (the other was the VII BMSP). The previous meetings in the BMSP series took place in the mountains of Minas Gerais, in the region of the Brazilian Pantanal, and in the shores of Paraíba. Now, for the first time, the Meeting was held in Florianópolis, with its pleasing shores, the capital of Santa Catarina state. The VIII BMSP brought together about 50 researchers from all over the world for a vibrant and productive conference. As in the previous meetings, the talks and posters highlighted recent advances in applications, algorithms, and implementation of computer simulation methods for the study of condensed matter, materials, and out of equilibrium, quantum and biologically motivated systems. We are sure that this meeting series will continue to be an important occasion for people working in simulational physics to exchange ideas and discuss the state of the art of this always expanding field. We are very glad to put together this special issue, and are most appreciative of the efforts of the editors of the Journal of Physics: Conference Series for making this publication possible. We are grateful for the outstanding work of the Florianopolis team, for the financial support of the Brazilian agencies CAPES and CNPq, and of the Federal Universities UFPB and UFSC. At last, but not least, we would like to acknowledge all of the authors for their written submissions. (paper)

  17. Factoring in Factor VIII With Acute Ischemic Stroke. (United States)

    Siegler, James E; Samai, Alyana; Albright, Karen C; Boehme, Amelia K; Martin-Schild, Sheryl


    There is growing research interest into the etiologies of cryptogenic stroke, in particular as it relates to hypercoagulable states. An elevation in serum levels of the procoagulant factor VIII is recognized as one such culprit of occult cerebral infarctions. It is the objective of the present review to summarize the molecular role of factor VIII in thrombogenesis and its clinical use in the diagnosis and prognosis of acute ischemic stroke. We also discuss the utility of screening for serum factor VIII levels among patients at risk for, or those who have experienced, ischemic stroke. © The Author(s) 2015.

  18. AAV5-Factor VIII Gene Transfer in Severe Hemophilia A. (United States)

    Rangarajan, Savita; Walsh, Liron; Lester, Will; Perry, David; Madan, Bella; Laffan, Michael; Yu, Hua; Vettermann, Christian; Pierce, Glenn F; Wong, Wing Y; Pasi, K John


    Patients with hemophilia A rely on exogenous factor VIII to prevent bleeding in joints, soft tissue, and the central nervous system. Although successful gene transfer has been reported in patients with hemophilia B, the large size of the factor VIII coding region has precluded improved outcomes with gene therapy in patients with hemophilia A. We infused a single intravenous dose of a codon-optimized adeno-associated virus serotype 5 (AAV5) vector encoding a B-domain-deleted human factor VIII (AAV5-hFVIII-SQ) in nine men with severe hemophilia A. Participants were enrolled sequentially into one of three dose cohorts (low dose [one participant], intermediate dose [one participant], and high dose [seven participants]) and were followed through 52 weeks. Factor VIII activity levels remained at 3 IU or less per deciliter in the recipients of the low or intermediate dose. In the high-dose cohort, the factor VIII activity level was more than 5 IU per deciliter between weeks 2 and 9 after gene transfer in all seven participants, and the level in six participants increased to a normal value (>50 IU per deciliter) that was maintained at 1 year after receipt of the dose. In the high-dose cohort, the median annualized bleeding rate among participants who had previously received prophylactic therapy decreased from 16 events before the study to 1 event after gene transfer, and factor VIII use for participant-reported bleeding ceased in all the participants in this cohort by week 22. The primary adverse event was an elevation in the serum alanine aminotransferase level to 1.5 times the upper limit of the normal range or less. Progression of preexisting chronic arthropathy in one participant was the only serious adverse event. No neutralizing antibodies to factor VIII were detected. The infusion of AAV5-hFVIII-SQ was associated with the sustained normalization of factor VIII activity level over a period of 1 year in six of seven participants who received a high dose, with

  19. Idiopathic Acquired Hemophilia A with Undetectable Factor VIII Inhibitor

    Directory of Open Access Journals (Sweden)

    Nicholas B. Abt


    Full Text Available Objective. We present the case of a 73-year-old female, with no family or personal history of a bleeding disorder, who had a classic presentation for acquired hemophilia A. Factor VIII activity was low but detectable and a factor VIII inhibitor was undetectable. Methods. The patient’s plasma was comprehensively studied to determine the cause of the acquired coagulopathy. Using the Nijmegen modification of the Bethesda assay, no factor VIII autoantibody was measureable despite varying the incubation time from 1 to 3 hours. Results. The aPTT was prolonged at 46.8 seconds, which did not correct in the 4 : 1 mix but did with 1 : 1 mix. Using a one stage factor VIII activity assay, the FVIII activity was 16% and chromogenic FVIII activity was also 16%. The patient was treated with recombinant FVII and transfusion, significantly reducing bleeding. Long-term therapy was initiated with cyclophosphamide and prednisone with normalization of FVIII activity. Conclusions. Physicians can be presented with the challenging clinical picture of an acquired factor VIII inhibitor without a detectable inhibitor by the Bethesda assay. Standard therapy for an acquired hemophilia A should be considered.

  20. VIII International Congress of Engineering Physics

    International Nuclear Information System (INIS)


    The Physicist Engineering is a multidisciplinary profession in which an undergraduate student integrates and applies their knowledge of Physics, Mathematics, and Computing to adapt and innovate all kind of technologies, as well as to development and apply theoretical knowledge to different fields of science and engineering. A Physicist Engineer, supported by a solid preparation in science and engineering is available to study, analyze, identify, and solve problems in different fields of science and technology for industries, hospitals, research laboratories, institutes and governmental organizations focused on metrology, optics, energy, materials, instrumentation of sophisticated equipment. The Physicist Engineering bachelor degree is a national and international reference to encouraging all those students to apply knowledge through active participation in the operation, planning, and management of projects. The technological and scientific impact of a Physicist Engineering undergraduate and graduate students, as well as the tutorial of the research professor that are interested in Physics and Physics Engineering, may be found in a biennial event like the International Conference on Physicist Engineering, through the diffusion of both experimental and theoretical research and teaching. In order to promote and encourage strength academic goals among universities and research institutions, the International Conference on Physics Engineering Committee, integrated by a faculty meeting of the Universidad Autónoma Metropolitana, Campus Azcapotzalco, has decided to grant the VIII International Congress of Physics Engineering to the Universidad Autónoma de Yucatán, which is going to take place on Mérida, November 7 th to 11 th , 2016. This conference considers different topics as: Renewables Energies Engineering Materials Technology Nanotechnology Medical Physics Education in Physics Engineering Nuclear Engineering High Precision Instrumentation Atmosphere Physics

  1. Acquired high titre factor VIII inhibitor with underlying polyarteritis nodosa. (United States)

    Snowden, J A; Hutchings, M; Spearing, R; Patton, W N


    We here present the case of a 70-year-old woman referred to our unit for investigation of bleeding. Investigations confirmed a high titre acquired Factor VIII inhibitor. In association there was relapse of systemic illness associated with anti-neutrophil cytoplasmic antibodies (atypical pattern) for which she had been treated five years previously. Immunosuppression was attempted, but it failed to have an impact both on the inhibitor titre and on the underlying disorder. The patient died from multi-organ failure and massive chest hemorrhage. Post-mortem showed necrotizing vasculitis of medium sized vessels at several sites, including the kidney, consistent with a diagnosis of polyarteritis nodosa. Although it is well recognised that Factor VIII inhibitors are found in conjunction with autoimmune disorders, this case is significant in that it is the first associated with histologically proven polyarteritis nodosa type vasculitis. The case illustrates the difficulties in the investigation and management of patients with acquired high titre Factor VIII inhibitors.

  2. Igor Zabel 14. VIII 1958 - 23. VII 2005

    Index Scriptorium Estoniae


    Igor Zabel oli Ida-Euroopa tuntumaid kunstiteoreetikuid ja kuraatoreid. Töötas 1986. aastast Ljubljana moodsa kunsti muuseumi kuraatorina. 9. VIII avatakse seal viimane I. Zabeli kureeritud näitus "Territories, Identities, Nets-Slovene Art 1995-2005"

  3. Extended analyses of Se VII and Se VIII

    International Nuclear Information System (INIS)

    Vankleef, Th.A.M.; Joshi, Y.N.


    Joshi et al. (1984) have conducted an analysis of the 3d8 4s-3d8 4p transitions in As VII. The present investigation is concerned with an analysis of similar transitions in Se VIII. The selenium spectrum was photographed in the 400-1200-A wavelength region on a variety of normal-incidence spectrographs. Attention is given to least-squares-fit (LSF) and Hartree-Fock (HF) parameter values for the 3d9 4d configuration of Se VII, LSF and HF parameter values for the 3d8 4s and 3d8 4p configurations of Se VIII, the energy and composition of the levels of the 3d9 4d configuration of Se VII, classified lines in Se VII, energy levels and composition of the 3d8 4s configuration and the revised and newly determined levels of the 3d8 4p configuration of Se VIII, and newly classified lines of Se VIII. 15 references

  4. Factor VIII-associated antigen in human lymphatic endothelium. (United States)

    Nagle, R B; Witte, M H; Martinez, A P; Witte, C L; Hendrix, M J; Way, D; Reed, K


    Lymphatic vascular endothelium both on tissue section and in culture exhibits positivity for Factor VIII-associated antigen although staining is generally less intense and more spotty than in comparable blood vascular endothelium. Lymphatic endothelium also exhibits Weibel-Palade bodies. Neither marker, therefore, reliably distinguishes blood vascular endothelium from lymphatic endothelium.

  5. Gas mission; Mission gaz

    Energy Technology Data Exchange (ETDEWEB)



    This preliminary report analyses the desirable evolutions of gas transport tariffing and examines some questions relative to the opening of competition on the French gas market. The report is made of two documents: a synthesis of the previous report with some recommendations about the tariffing of gas transport, about the modalities of network access to third parties, and about the dissociation between transport and trade book-keeping activities. The second document is the progress report about the opening of the French gas market. The first part presents the European problem of competition in the gas supply and its consequences on the opening and operation of the French gas market. The second part presents some partial syntheses about each topic of the mission letter of the Ministry of Economics, Finances and Industry: future evolution of network access tariffs, critical analysis of contractual documents for gas transport and delivery, examination of auxiliary services linked with the access to the network (modulation, balancing, conversion), consideration about the processing of network congestions and denied accesses, analysis of the metering dissociation between the integrated activities of gas operators. Some documents are attached in appendixes: the mission letter from July 9, 2001, the detailed analysis of the new temporary tariffs of GdF and CFM, the offer of methane terminals access to third parties, the compatibility of a nodal tariffing with the presence of three transport operators (GdF, CFM and GSO), the contract-type for GdF supply, and the contract-type for GdF connection. (J.S.)

  6. [The mission]. (United States)

    Ruiz Moreno, J; Blanch Mon, A


    After having made a historical review of the concept of mission statement, of evaluating its importance (See Part I), of describing the bases to create a mission statement from a strategic perspective and of analyzing the advantages of this concept, probably more important as a business policy (See Parts I and II), the authors proceed to analyze the mission statement in health organizations. Due to the fact that a mission statement is lacking in the majority of health organizations, the strategy of health organizations are not exactly favored; as a consequence, neither are its competitive advantage nor the development of its essential competencies. After presenting a series of mission statements corresponding to Anglo-Saxon health organizations, the authors highlight two mission statements corresponding to our social context. The article finishes by suggesting an adequate sequence for developing a mission statement in those health organizations having a strategic sense.

  7. New study on the XeVIII spectrum

    International Nuclear Information System (INIS)

    Gallardo, M.; Raineri, M.; Giuliani, M.; Lagorio, C.; Padilla, S.; Sarmiento, R.; Reyna Almandos, J.G.


    Capillary light sources were used to observe the spectrum of seven-times-ionized xenon, XeVIII, in the 300-6000 A wavelength range. Twenty-eight energy levels belonging to the 5s-9s, 5d-9d, 5g-9g, 7i-10i, 9l, 5p-9p, 4f-9f, 6h-9h and 8k-10k configurations were adjusted and 38 new spectral lines were classified. The XeVIII ionization energy was determined with improved accuracy using the polarization model. The analysis was supported by Hartree-Fock calculations. The weighted oscillator strengths for all the observed spectral lines were also calculated considering the fitted values for the energy parameters

  8. Evidence for the formation of sodium hassate(VIII)

    International Nuclear Information System (INIS)

    Zweidorf, A. von; Angert, R.; Bruechle, W.; Buerger, S.; Eberhardt, K.; Eichler, R.; Hummrich, H.; Jaeger, E.; Kling, H.O.; Kratz, J.V.; Kuczewski, B.; Langrock, G.; Mendel, M.; Rieth, U.; Schaedel, M.; Schausten, B.; Schimpf, E.; Thoerle, P.; Trautmann, N.; Tsukada, K.; Wiehl, N.; Wirth, G.


    Hassium, element 108, was produced in the fusion reaction between 26 Mg and 248 Cm. The hassium recoils were oxidized in-situ to a highly volatile oxide, presumably HsO 4 , and were transported in a mixture of He and O 2 to a deposition and detection system. The latter consisted of 16 silicon PIN-photodiodes facing a layer of NaOH, which served, in the presence of a certain partial pressure of water in the transport gas, as reactive surface for the deposition of the volatile tetroxides. Six correlated α-decay chains of Hs were detected in the first 5 detectors centred around detection position 3. In analogy to OsO 4 , which forms Na 2 [OsO 4 (OH) 2 ], an osmate(VIII), with aqueous NaOH, HsO 4 presumably was deposited as Na 2 [HsO 4 (OH) 2 ], a hassate(VIII). (orig.)

  9. Henry VIII, McLeod syndrome and Jacquetta's curse. (United States)

    Stride, P; Lopes Floro, K


    The mental decline of King Henry VIII from being a jovial, charismatic and athletic young man into an increasingly paranoid, brutal tyrant in later life, ever more concerned at his lack of one or more male heirs, has attracted many medical diagnostic theories. Previous hypotheses have included diabetes, syphilis and hypothyroidism, among others. However, these inadequately explain Henry's failure to produce a male heir, despite multiple pairings. The latest postulated diagnoses for Henry are the coexistence of both Kell blood group antigenicity (possibly inherited from Jacquetta Woodville, Henry's maternal great grandmother) causing related impaired fertility, and McLeod syndrome, causing psychotic changes. As the mutated McLeod protein of the syndrome significantly reduces the expression, effectively inactivating the Kell antigen, we critically review this theory, examining in detail the pathophysiology of these conditions and assessing the genealogy of Henry VIII and its effect in subsequent generations.

  10. New study on the XeVIII spectrum

    Energy Technology Data Exchange (ETDEWEB)

    Gallardo, M. [Centro de Investigaciones Opticas (CIOp) Casilla de Correo 124, 1900 La Plata (Argentina)]. E-mail:; Raineri, M. [Centro de Investigaciones Opticas (CIOp) Casilla de Correo 124, 1900 La Plata (Argentina)]. E-mail:; Giuliani, M. [Dto. de Fisica, Fac. de C. Exactas y Naturales, Universidad Nacional de Mar del Plata Funes 3350 (7600) Mar del Plata (Argentina); Lagorio, C. [Dto. de Fisica, Fac. de C. Exactas y Naturales, Universidad Nacional de Mar del Plata Funes 3350 (7600) Mar del Plata (Argentina); Padilla, S. [Dto. de Fisica, Fac. de C. Exactas y Naturales, Universidad Nacional de Mar del Plata Funes 3350 (7600) Mar del Plata (Argentina); Sarmiento, R. [Dto. De Fisica, Universidad del Atlantico, A.A 1890 Barranquilla (Colombia); Reyna Almandos, J.G. [Centro de Investigaciones Opticas (CIOp) Casilla de Correo 124, 1900 La Plata (Argentina)]. E-mail:


    Capillary light sources were used to observe the spectrum of seven-times-ionized xenon, XeVIII, in the 300-6000 A wavelength range. Twenty-eight energy levels belonging to the 5s-9s, 5d-9d, 5g-9g, 7i-10i, 9l, 5p-9p, 4f-9f, 6h-9h and 8k-10k configurations were adjusted and 38 new spectral lines were classified. The XeVIII ionization energy was determined with improved accuracy using the polarization model. The analysis was supported by Hartree-Fock calculations. The weighted oscillator strengths for all the observed spectral lines were also calculated considering the fitted values for the energy parameters.

  11. The spectrum and term system of S VIII

    International Nuclear Information System (INIS)

    Bengtsson, P.; Jupen, C.; Engstroem, L.; Redfors, A.; Westerlind, M.


    The spectrum of seven times ionized sulfur, S VIII, has been observed in the wavelength range 50-1200 A. Both beam-foil and laser-produced plasma light sources have been used. 71 new lines representing the transitions 2p 5 -2p 4 3d, 2p 4 3s-3p, 3p-3d, 3d-4f, 4f-5g and 5g-6h have been identified and 100 energy levels, of which 46 are new, are now accurately established. The spectral analysis is supported by isoelectronic comparisons along the F I-sequence and by parametric least-squares fits of Slater integrals to the observed levels. The ionization potential in S VIII is determined to 2 651 899 ± 60 cm -1 and estimated ionization energies are derived for the isoelectronic elements between F I and Ar X. (orig.)

  12. Progress toward inducing immunologic tolerance to factor VIII


    Scott, David W.; Pratt, Kathleen P.; Miao, Carol H.


    A major problem in treating hemophilia A patients with therapeutic factor VIII (FVIII) is that 20% to 30% of these patients produce neutralizing anti-FVIII antibodies. These antibodies block (inhibit) the procoagulant function of FVIII and thus are termed “inhibitors.” The currently accepted clinical method to attempt to eliminate inhibitors is immune tolerance induction (ITI) via a protocol requiring intensive FVIII treatment until inhibitor titers drop. Although often successful, ITI is ext...

  13. Characterization of five partial deletions of the factor VIII gene

    International Nuclear Information System (INIS)

    Youssoufian, H.; Antonarakis, S.E.; Aronis, S.; Tsiftis, G.; Phillips, D.G.; Kazazian, H.H. Jr.


    Hemophilia A is an X-linked disorder of coagulation caused by a deficiency of factor VIII. By using cloned DNA probes, the authors have characterized the following five different partial deletions of the factor VIII gene from a panel of 83 patients with hemophilia A: (i) a 7-kilobase (kb) deletion that eliminates exon 6; (ii) a 2.5-kb deletion that eliminates 5' sequences of exon 14; (iii) a deletion of at least 7 kb that eliminates exons 24 and 25; (iv) a deletion of at least 16 kb that eliminates exons 23-25; and (v) a 5.5-kb deletion that eliminates exon 22. The first four deletions are associated with severe hemophilia A. By contrast, the last deletion is associated with moderate disease, possibly because of in-frame splicing from adjacent exons. None of those patients with partial gene deletions had circulating inhibitors to factor VIII. One deletion occurred de novo in a germ cell of the maternal grandmother, while a second deletion occurred in a germ cell of the maternal grandfather. These observations demonstrate that de novo deletions of X-linked genes can occur in either male or female gametes

  14. Chromogenic Factor VIII Assays for Improved Diagnosis of Hemophilia A. (United States)

    Rodgers, Susan; Duncan, Elizabeth


    Hemophilia A is an inherited bleeding disorder caused by a reduced level of factor VIII coagulant activity (FVIII:C) in blood. Bleeding episodes may occur spontaneously in the severe form of hemophilia or after trauma in the milder forms. It is important that patients are diagnosed correctly, which includes placing them into the correct severity category of the disorder so that appropriate treatment can be given. Diagnosis is made by determination of the amount of FVIII:C in the blood, usually using a one-stage factor VIII:C assay. However, approximately one third of patients with mild or moderate hemophilia will have much lower results by the chromogenic assay, with some of them having normal results by the one-stage assay. The chromogenic factor VIII assay is used in some specialized hemophilia reference centers and is recommended for the diagnosis of mild hemophilia A, as this assay is considered to better reflect the severity status of hemophilia patients than the one-stage assay.

  15. [Myanmar mission]. (United States)

    Alfandari, B; Persichetti, P; Pelissier, P; Martin, D; Baudet, J


    The authors report the accomplishment of humanitarian missions in plastic surgery performed by a small team in town practice in Yangon, about their 3 years experience in Myanmar with 300 consultations and 120 surgery cases. They underline the interest of this type of mission and provide us their reflexion about team training, the type of relation with the country where the mission is conducted and the type of right team.

  16. Ehlers-Danlos Syndrome Type VIII: A Rare Cause of Leg Ulcers in Young Patients

    Directory of Open Access Journals (Sweden)

    Sophie Ronceray


    Full Text Available Ehlers-Danlos syndrome type VIII (EDS-VIII is a very rare autosomal dominant disease characterized by early-onset periodontitis associated with features of Ehlers-Danlos syndrome. We report a 32-year-old man whose chronic leg ulcer led to the diagnosis of EDS-VIII. He had severe periodontitis with complete loss of permanent teeth and skin fragility with thin skin, atrophic scars, and brownish atrophic pretibial plaques. Leg ulcer is not a prominent feature of EDS-VIII. We suggest adding EDS-VIII to the list of rare diseases accounting for chronic leg ulcers, if this case report prompts others to report leg ulcers associated with EDS-VIII.

  17. Differential proteolytic activation of factor VIII-von Willebrand factor complex by thrombin

    International Nuclear Information System (INIS)

    Hill-Eubanks, D.C.; Parker, C.G.; Lollar, P.


    Blood coagulation factor VIII (fVIII) is a plasma protein that is decreased or absent in hemophilia A. It is isolated as a mixture of heterodimers that contain a variably sized heavy chain and a common light chain. Thrombin catalyzes the activation of fVIII in a reaction that is associated with cleavages in both types of chain. The authors isolated a serine protease from Bothrops jararacussu snake venom that catalyzes thrombin-like heavy-chain cleavage but not light-chain cleavage in porcine fVIII as judged by NaDodSO 4 /PAGE and N-terminal sequence analysis. Using a plasma-free assay of the ability of activated 125 I-fVIII to function as a cofactor in the activation of factor X by factor IXa, they found that fVIII is activated by the venom enzyme. The venom enzyme-activated fVIII was isolated in stable form by cation-exchange HPLC. von Willebrand factor inhibited venom enzyme-activated fVIII but not thrombin-activated fVIII. These results suggest that the binding of fVIII to von Willebrand factor depends on the presence of an intact light chain and that activated fVIII must dissociate from von Willebrand factor to exert its cofactor effect. Thus, proteolytic activation of fVIII-von Willebrand factor complex appears to be differentially regulated by light-chain cleavage to dissociate the complex and heavy-chain cleavage to activate the cofactor function

  18. 40 CFR Appendix Viii to Part 600 - Fuel Economy Label Formats (United States)


    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Fuel Economy Label Formats VIII... POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Pt. 600, App. VIII Appendix VIII to Part 600—Fuel Economy Label Formats EC01MY92.117 EC01MY92.118 EC01MY92.119 EC01MY92.120...

  19. Thermoelectrical properties of the compounds ScM{sup VIII}Sb and YM{sup VIII}Sb (M{sup VIII} = Ni, Pd, Pt)

    Energy Technology Data Exchange (ETDEWEB)

    Oestreich, J; Probst, U; Richardt, F; Bucher, E [University of Konstanz, PO Box X916, D-78457 Konstanz (Germany)


    The research into new materials with good thermoelectric properties has revealed new compounds consisting of metallic elements (Bando Y, Suemitsu T, Takagi K, Tokushima H, Echizen Y, Katoh K, Umeo K, Maeda Y and Takabatake T 2000 J. Alloys Compounds 313 1-6, Ghelani N, Loo S, Chung D, Sportouch S, Nardi S, Kanatzidis M, Hogan T and Nolas G 2000 Mater. Res. Soc. 626 Z8.6.1). The half-Heusler compound ZrNiSn, in particular, shows promising thermoelectric properties and has been studied by many scientists during recent years (Uher C, Hu S, Yang J, Meisner G P and Morelli D T 1997 Proc. ICT'97: 16th Int. Conf. on Thermoelectrics pp 485-8, Romaka L P, Stadnyk Yu V, Goryn A M, Gorelenko Yu K and Skolozdra R V 1997 Proc. ICT'97: 16th Int. Conf. on Thermoelectrics pp 516-19, Hohl H, Ramirez A P, Goldmann C, Ernst G, Woelfing B and Bucher E 1998 J. Phys.: Condens. Matter 11 1697-709, Oestreich J, Kaefer W, Richardt F, Probst U and Bucher E 1999 Proc. 5th European Workshop on Thermoelectrics pp 192-5). In an effort to find new thermoelectric materials, the half-Heusler compounds of the groups ScM{sup VIII}Sb and YM{sup VIII}Sb (M{sup VIII} = Ni, Pd, Pt) were synthesized by arc melting and the thermoelectric properties were examined by standard characterization methods. Doping experiments showed that it is possible to change the electrical properties of the compounds while retaining the half-Heusler structure. Within the two groups, YPtSb showed the best thermoelectrical properties. At a temperature of 400 K the electrical conductivity of YPtSb is 748{omega}{sup -1} cm{sup -1} and the Seebeck coefficient is 116.3{mu}V K{sup -1}. The thermal conductivity at 400 K extrapolated using the Wiedemann-Franz law is 2.87 W K{sup -1} m{sup -1}. This leads to a dimensionless figure of merit of 0.14.

  20. Factor VIII gene (F8) mutation and risk of inhibitor development in nonsevere hemophilia a

    NARCIS (Netherlands)

    C.L. Eckhardt (Corien); A.S. van Velzen (Alice); M.A.D. Peters (Marjolein); J. Astermark (Jan); P.P. Brons; G. Castaman (Giancarlo); M.H. Cnossen (Marjon); N. Dors (N.); C. Escuriola-Ettingshausen (Carmen); K. Hamulyák (K.); D.P. Hart (Daniel); C.R.M. Hay (Charles R.); S. Haya (Saturnino); W.L. van Heerde; C. Hermans (Cédric); M. Holmström (Margareta); V. Jimenez-Yuste (Victor); R.D. Keenan (Russell); R. Klamroth (Robert); B.A.P. Laros-Van Gorkom (Britta); F.W.G. Leebeek (Frank); R. Liesner (Ri); A. Mäkipernaa (Anne); C. Male (Christoph); E.P. Mauser-Bunschoten (Eveline); M.G. Mazzucconi (Maria); S. McRae (Simon); K. Meijer (K.); M. Mitchell (Michael); M. Morfini (Massimo); M.R. Nijziel (Marten); J. Oldenburg (Jan); K. Peerlinck; P. Petrini (Pia); H. Platokouki (Helena); S.E. Reitter-Pfoertner (Sylvia); E. Santagostino (Elena); P. Schinco (Piercarla); F.J.W. Smiers (Frans); K.D. Siegmund (Kimberly); A. Tagliaferri (Annarita); T.T. Yee (Thynn); P.W. Kamphuisen (Pieter Willem); J.G. van der Bom (Anske); K. Fijnvandraat


    textabstractNeutralizing antibodies (inhibitors) toward factor VIII form a severe complication in nonsevere hemophilia A, profoundly aggravating the bleeding pattern. Identification of high-risk patients is hampered by lack of data that take exposure days to therapeutic factor VIII concentrates into

  1. 40 CFR Appendix Viii to Part 266 - Organic Compounds for Which Residues Must Be Analyzed (United States)


    ... AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Pt. 266, App. VIII Appendix VIII to Part 266... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Organic Compounds for Which Residues...

  2. 40 CFR Appendix Viii to Part 268 - LDR Effective Dates of Injected Prohibited Hazardous Wastes (United States)


    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false LDR Effective Dates of Injected Prohibited Hazardous Wastes VIII Appendix VIII to Part 268 Protection of Environment ENVIRONMENTAL PROTECTION... to Part 268—LDR Effective Dates of Injected Prohibited Hazardous Wastes National Capacity LDR...

  3. Type VIII collagen is elevated in diseases associated with angiogenesis and vascular remodeling

    DEFF Research Database (Denmark)

    Hansen, N. U. B.; Willumsen, N.; Bülow Sand, Jannie Marie


    Objectives Type VIII collagen is involved in angiogenesis and remodeling of arteries. We hypothesized that type VIII collagen was upregulated in diseases associated with vascular remodeling, e.g. pulmonary fibrosis and cancer. In this paper we present the development and validation of a competitive...

  4. Effectiveness of Mind Mapping in English Teaching among VIII Standard Students (United States)

    Hallen, D.; Sangeetha, N.


    The aim of the study is to find out the effectiveness of mind mapping technique over conventional method in teaching English at high school level (VIII), in terms of Control and Experimental group. The sample of the study comprised, 60 VIII Standard students in Tiruchendur Taluk. Mind Maps and Achievement Test (Pretest & Posttest) were…

  5. 4p-5s transitions in YVII, VIII, ZrVIII, IX, NbIX, X and MoX, XI

    International Nuclear Information System (INIS)

    Rahimullah, K.; Chaghtai, M.S.Z.; Khatoon, S.


    The spectra of Y VII, VIII, Zr VIII, IX, Nb X and Mo X, XI are studied for the first time and the 1971 analysis of Nb IX is improved. By analyses of the transitions 4s 2 4psup(k)-4s 2 4psup(k-1)5s all the levels of the configurations 4p 3 , 4p 2 5s, 4p 2 and 4p5s are established in the spectra concerned. (Auth.)

  6. Efeitos de humor no poema VIII de Catulo

    Directory of Open Access Journals (Sweden)

    Paulo Sérgio Vasconcellos


    Full Text Available Neste artigo apresenta-se uma contribuição ao estudo dos efeitos de humor no poema VIII de Catulo; de fato, além do metro dessa composição e de outros elementos criadores de distanciamento irônico que os estudiosos têm apontado, um outro aspecto de sua forma, ainda pouco percebido, guia a leitura para essa interpretação: o jogo, a maneira de anagrama imperfeito (o “hipograma”, ou, mais precisamente, “criptograma”, de Saussure, com os sons do nome da amada, aparentemente calado. E mais uma das maneiras com que o poeta elabora a jocosa diferença entre o que se diz e o que, sentido e reprimido, deixa-se, porém, transparecer.

  7. Acquired factor VIII inhibitor syndrome: A rare cause of hematuria

    Directory of Open Access Journals (Sweden)

    Muthuvel Seral Kannan


    Full Text Available A 50-year-old woman presented with gross hematuria for 1 month. Clinical examinations, laboratory investigations, ultrasound and contrast computed tomography were normal, except anemia. Cystoscopy revealed bloody efflux from the right side. Retrograde pyelogram showed filling defect in the renal pelvis and biopsy was inconclusive. Renal angiogram was normal. She developed ecchymosis on the right thigh and arm with elevated activated partial thromboplastin time. The partial thromboplastin time correction study and Bethesda study confirmed the presence of acquired factor VIII inhibitor (acquired hemophilia. With flexible ureterorenoscopy, the mass in the renal pelvis was removed and its histopathology revealed clotted blood. The patient was subsequently managed with steroids and Factor eight inhibitor bypass activity.

  8. Energies and lifetimes of excited states in copperlike Kr VIII

    International Nuclear Information System (INIS)

    Livingston, A.E.; Curtis, L.J.; Schectman, R.M.; Berry, H.G.


    The spectrum of Kr VIII has been observed between 180 and 2000 A by using foil excitation of 2.5--3.5-MeV krypton ions. Twenty new transitions have been classified and eleven new excited-state energies have been determined within the n=4 --7 shells. The ionization potential is derived to be 1 015 800 +- 200 cm -1 . The excited-state energies and fine structures are compared with recent relativistic Hartree-Fock calculations. The 4p-state lifetime has been measured by performing a simultaneous analysis of decay data for the 4p level and for its dominant cascade-repopulating levels. The 4p lifetime is found to be 30% shorter than previously measured values and is in excellent agreement with the result of a recent multiconfiguration Hartree-Fock calculation. The source of the discrepancy between this result and earlier measurements is discussed

  9. Time Transfer Experiment by TCE on the ETS-VIII Satellite

    National Research Council Canada - National Science Library

    Nakagawa, Fumimaru; Takahashi, Yasuhiro; Amagai, Jun; Tabuchi, Ryo; Hama, Shin'ichi; Hosokawa, Mizuhiko


    .... At NICT, we developed Time Comparison Equipment (TCE) both onboard ETS-VIII and in the Earth station for precise time transfer between the atomic clocks on the satellite and a ground reference clock...

  10. Class VIII Medical Materiel Controls in the U.S. European Command

    National Research Council Canada - National Science Library


    .... Class VIII medical materiel inventories are maintained as part of the U.S. war reserve stocks to ensure military readiness and to provide needed health care during wartime or contingencies. The U.S...

  11. Mechanistic aspects of Os(VIII) catalysed oxidation of loop diuretic ...

    Indian Academy of Sciences (India)

    furosemide by Ag(III) periodate complex in aqueous alkaline medium. SHWETA J .... Os(VIII) catalysed DPA oxidation, the order in [OH. −. ] ... Victoria-3170, Australia) connected to a rapid ..... follows. The furosemide, periodate and hydroxide ion.

  12. Spectra of the W VIII isoelectronic sequence: III. Re IX

    International Nuclear Information System (INIS)

    Ryabtsev, A N; Kononov, E Ya; Kildiyarova, R R; Tchang-Brillet, W-Ü L; Wyart, J-F; Champion, N; Blaess, C


    Rhenium spectra excited in vacuum spark sources of different setups and electric circuits were recorded on two high resolution vacuum spectrographs: a 10 m normal incidence spectrograph with a 3600 l mm −1 grating in the Meudon Observatory and a 3 m grazing incidence spectrograph with a 3600 l mm −1 grating in the Institute of Spectroscopy in Troitsk. A total of 112 lines in the region 146–244 Å were identified as transitions from the interacting excited even configurations 4f 12 5s 2 5p 6 5d + 4f 13 5s 2 5p 5 (5d + 6s) + 4f 14 5s 2 5p 4 (5d + 6s) to the low-lying odd configurations 4f 13 5s 2 5p 6 and 4f 14 5s 2 5p 5 . A change of the ground configuration from 4f 13 5s 2 5p 6 to 4f 14 5s 2 5p 5 in a comparison with the previous spectra of the isoelectronic sequence Hf VI–W VIII was observed. Fine structure splittings and relative positions of the odd terms were established, and 83 levels of the excited even configurations were found. (paper)

  13. Agnostic stacking of intergalactic doublet absorption: measuring the Ne VIII population (United States)

    Frank, Stephan; Pieri, Matthew M.; Mathur, Smita; Danforth, Charles W.; Shull, J. Michael


    We present a blind search for doublet intergalactic metal absorption with a method dubbed `agnostic stacking'. Using a forward-modelling framework, we combine this with direct detections in the literature to measure the overall metal population. We apply this novel approach to the search for Ne VIII absorption in a set of 26 high-quality COS spectra. We probe to an unprecedented low limit of log N>12.3 at 0.47≤z ≤1.34 over a path-length Δz = 7.36. This method selects apparent absorption without requiring knowledge of its source. Stacking this mixed population dilutes doublet features in composite spectra in a deterministic manner, allowing us to measure the proportion corresponding to Ne VIII absorption. We stack potential Ne VIII absorption in two regimes: absorption too weak to be significant in direct line studies (12.3 13.7). We do not detect Ne VIII absorption in either regime. Combining our measurements with direct detections, we find that the Ne VIII population is reproduced with a power-law column density distribution function with slope β = -1.86 ^{+0.18 }_{ -0.26} and normalization log f_{13.7} = -13.99 ^{+0.20 }_{ -0.23}, leading to an incidence rate of strong Ne VIII absorbers dn/dz =1.38 ^{+0.97 }_{ -0.82}. We infer a cosmic mass density for Ne VIII gas with 12.3 value significantly lower that than predicted by recent simulations. We translate this density into an estimate of the baryon density Ωb ≈ 1.8 × 10-3, constituting 4 per cent of the total baryonic mass.

  14. On existence and properties of plutonium(VIII) derivatives

    Energy Technology Data Exchange (ETDEWEB)

    Kiselev, Yu.M.; Dolzhenko, V.D.; Ermilov, A.Yu. [Moscow State Univ. (Russian Federation). Chemistry Dept.; Nikonov, M.V.; Myasoedov, B.F. [Russian Academy of Science, Moscow (Russian Federation). Inst. of Geochemistry and Analytical Chemistry; Tananaev, I.G. [Russian Academy of Science, Moscow (Russian Federation). Inst. of Physical Chemistry and Electrochemistry


    The existence of Pu(VIII) was shown in alkaline solutions and in nonpolar solvents (CCl{sub 4} and CHCl{sub 3}) on the ground of such experimental facts like extraction of plutonium species, obtained by means of ozonization of Pu(VI) alkaline solutions into CCl{sub 4} and CHCl{sub 3}; volatility of Pu compounds out of aqueous alkaline solutions, and the mentioned solvents. The product of interaction between PuO{sub 3}.0.8H{sub 2}O and XeF{sub 2} in CCl{sub 4} and CHCl{sub 3} was of the same chemical form for both cases and identical with the form of the product of volatility of Pu out of these organic solutions. The electronic absorbance spectra of these products in CCl{sub 4} and CHCl{sub 3} were fairly similar to the ones for OsO{sub 4} and RuO{sub 4}. The band of absorption in these spectra with the maximum at 332 nm corresponds to the charge transfer of metal-ligand type [π(O)→Pu], as the value of molar extinction coefficient e was found to be higher than 2 x 10{sup 3} L/mole cm. A satisfactory agreement between the energies for the transitions of PuO{sub 4} molecule designed by X{sub α}-SW method and experimental data was observed. A similar accordance was observed for the designed vibration frequency (DFT-method) with the one found as result of analysis of the vibration structure of the experimental spectra. (orig.)

  15. Myosin VIII regulates protonemal patterning and developmental timing in the moss Physcomitrella patens. (United States)

    Wu, Shu-Zon; Ritchie, Julie A; Pan, Ai-Hong; Quatrano, Ralph S; Bezanilla, Magdalena


    Plants have two classes of myosins. While recent work has focused on class XI myosins showing that myosin XI is responsible for organelle motility and cytoplasmic streaming, much less is known about the role of myosin VIII in plant growth and development. We have used a combination of RNAi and insertional knockouts to probe myosin VIII function in the moss Physcomitrella patens. We isolated Δmyo8ABCDE plants demonstrating that myosin VIII is not required for plant viability. However, myosin VIII mutants are smaller than wild-type plants in part due to a defect in cell size. Additionally, Δmyo8ABCDE plants produce more side branches and form gametophores much earlier than wild-type plants. In the absence of nutrient media, Δmyo8ABCDE plants exhibit significant protonemal patterning defects, including highly curved protonemal filaments, morphologically defective side branches, as well as an increase in the number of branches. Exogenous auxin partially rescues protonemal defects in Δmyo8ABCDE plants grown in the absence of nutrients. This result, together with defects in protonemal branching, smaller caulonemal cells, and accelerated development in the Δmyo8ABCDE plants, suggests that myosin VIII is involved in hormone homeostasis in P. patens.

  16. The F309S mutation increases factor VIII secretion in human cell line

    Directory of Open Access Journals (Sweden)

    Daianne Maciely Carvalho Fantacini


    Full Text Available ABSTRACT OBJECTIVES: The capacity of a human cell line to secrete recombinant factor VIII with a F309S point mutation was investigated, as was the effect of the addition of chemical chaperones (betaine and sodium-4-phenylbutyrate on the secretion of factor VIII. METHODS: This work used a vector with a F309S mutation in the A1 domain to investigate FVIII production in the HEK 293 human cell line. Factor VIII activity was measured by chromogenic assay. Furthermore, the effects of chemical drugs on the culture were evaluated. RESULTS: The addition of the F309S mutation to a previously described FVIII variant increased FVIII secretion by 4.5 fold. Moreover, the addition of betaine or sodium-4-phenylbutyrate increased the secretion rate of FVIIIΔB proteins in HEK 293 cells, but the same effect was not seen for FVIIIΔB-F309S indicating that all the recombinant protein produced had been efficiently secreted. CONCLUSION: Bioengineering factor VIII expressed in human cells may lead to an efficient production of recombinant factor VIII and contribute toward low-cost coagulation factor replacement therapy for hemophilia A. FVIII-F309S produced in human cells can be effective in vivo.

  17. Practical experience and lessons learned through implementation of Appendix VIII performance demonstration requirements

    International Nuclear Information System (INIS)

    Ashwin, P.J.; Becker, F.L.; Latiolais, C.L.; Spanner, J.C.


    To provide the US nuclear industry with a uniform implementation of the Performance Demonstration requirements within the 1989 edition of ASME Section XI, Appendix VIII, representatives from all US nuclear utilities formed the Performance Demonstration Initiative (PDI). The PDI recognized the potential benefits that Appendix VIII offered the nuclear industry and initiated a proactive approach to implement the requirements. In doing so it was expected that performance demonstration of ultrasonic examination procedures would allow for improvement in the efficiency and credibility of inservice inspection to be realized. Explicit within the performance demonstration requirements of Appendix VIII is the need for a Performance Demonstration Administrator, a difficult requirement to fulfill. Not only must the administrator exhibit the attributes of understanding the demonstration requirements, but also have solid technical knowledge, integrity and be able to interface with the industry at all levels, from operations to regulatory. For the nuclear industry, the EPRI NDE Center is an obvious choice to fulfill this position. This paper provides a brief background of the PDI, a nuclear industry-wide initiative to implement the performance demonstration requirements of Appendix VIII. Even though the consensus approach adopted by the PDI is discussed, the paper's primary objective is to provide examples of the lessons learned by the Center through the specific requirements of Appendix VIII

  18. Diagnostic accuracy study of a factor VIII ELISA for detection of factor VIII antibodies in congenital and acquired haemophilia A. (United States)

    Batty, Paul; Moore, Gary W; Platton, Sean; Maloney, James C; Palmer, Ben; Bowles, Louise; Pasi, K John; Rangarajan, Savita; Hart, Daniel P


    Antibody formation to factor VIII (FVIII) remains the greatest clinical and diagnostic challenge to the haemophilia-treating physician. Current guidance for testing for inhibitory FVIII antibodies (inhibitors) recommends the functional Nijmegen-Bethesda assay (NBA). A FVIII ELISA offers a complementary, immunological approach for FVIII antibody testing. It was the aim of this study to retrospectively evaluate the performance of a FVIII ELISA (index) for detection of FVIII antibodies, compared with the NBA (reference). All samples sent for routine FVIII antibody testing at two haemophilia Comprehensive Care Centres, were tested in parallel using the NBA and a solid-phase, indirect FVIII ELISA kit (Immucor). A total of 497 samples from 239 patients (severe haemophilia A=140, non-severe haemophilia A=85, acquired haemophilia A=14) were available for analysis. Sixty-three samples tested positive by the NBA (prevalence 12.7%, 95% confidence interval [CI], 9.9-15.9 %), with a median inhibitor titre of 1.2 BU/ml (range 0.7-978.0). The FVIII ELISA demonstrated a specificity of 94.0% (95%CI, 91.3-96.0), sensitivity of 77.8% (95%CI, 65.5-87.3), negative predictive value of 96.7% (95%CI, 94.5-98.2), positive predictive value 65.3% (95%CI, 53.5-76.0), negative likelihood ratio 0.2 (95%CI, 0.1-0.4), positive likelihood ratio 13.0 (95%CI, 8.7-19.3) and a diagnostic odds ratio of 54.9 (95%CI, 27.0-112.0). Strong positive correlation (r=0.77, pNBA (log adjusted) and FVIII ELISA optical density. In conclusion, FVIII ELISA offers a simple, specific, surveillance method enabling batch testing of non-urgent samples for the presence of FVIII antibodies.

  19. Hemodialysis in a patient with severe hemophilia A and factor VIII inhibitor. (United States)

    Gopalakrishnan, Natarajan; Usha, Thiruvengadam; Thopalan, Balasubramaniyan; Dhanapriya, Jeyachandran; Dineshkumar, Thanigachalam; Thirumalvalavan, Kaliaperumal; Sakthirajan, Ramanathan


    Hemophilia A is a hereditary X-linked recessive disease caused by mutations in the gene encoding factor VIII (FVIII), occurring in 1 out of 10,000 persons. Life expectancy and quality of life have dramatically improved recently in patients with hemophilia. Chronic kidney disease and need for renal replacement therapy in these patients are rare. The development of inhibitors to FVIII is the most serious complication of hemophilia and makes treatment of bleeds very challenging. We describe here a 28-year-old male patient with severe hemophilia A with presence of factor VIII inhibitor, who had end stage renal disease. Central venous access device was inserted along with infusion of factor eight inhibitor bypass activity before and after the procedure. He is currently on thrice weekly hemodialysis and doing well for 6 months without bleeding episodes. To our knowledge, hemophilia A with factor VIII inhibitor managed with hemodialysis has not been reported so far. © 2016 International Society for Hemodialysis.

  20. Spectrophotometric determination of hydrogen peroxide with osmium(VIII) and m-carboxyphenylfluorone. (United States)

    Hoshino, Mitsuru; Kamino, Shinichiro; Doi, Mitsunobu; Takada, Shingo; Mitani, Shota; Yanagihara, Rika; Asano, Mamiko; Yamaguchi, Takako; Fujita, Yoshikazu


    Spectrophotometric determination of hydrogen peroxide was accomplished with osmium(VIII) and m-carboxyphenylfluorone (MCPF) in the presence of cetyltrimethylammonium chloride (CTAC). In the determination of hydrogen peroxide based on the fading of the color of osmium(VIII)-MCPF complex, Beer's law was obeyed in the range 20-406 ng mL(-1), with an effective molar absorption coefficient (at 580 nm) of 5.21×10(4) L mol(-1) cm(-1) and a relative standard deviation of 0.33% (n=6). Further, we performed the characterization of MCPF and obtained the crystal structure. Copyright © 2013 Elsevier B.V. All rights reserved.

  1. Lacerations to Zones VIII and IX: It Is Not Just a Tendon Injury

    Directory of Open Access Journals (Sweden)

    Charla R. Fischer


    Full Text Available Extensor tendon injuries are widely believed to be straightforward problems that are relatively simple to manage. However, these injuries can be complex and demand a thorough understanding of anatomy to achieve the best functional outcomes. When lacerations occur in the forearm as in Zones VIII and IX injury, the repair of the extensor tendon and muscle, and posterior interosseous nerve (PIN is often challenging. A review of the literature shows little guidance and attention for these injuries. We present four patients with injuries to Zones VIII and IX as well as a review of surgical technique, postoperative rehabilitation, and pearls that may be of benefit to those managing these injuries.

  2. Analysis of mutations in the entire coding sequence of the factor VIII gene

    Energy Technology Data Exchange (ETDEWEB)

    Bidichadani, S.I.; Lanyon, W.G.; Connor, J.M. [Glascow Univ. (United Kingdom)] [and others


    Hemophilia A is a common X-linked recessive disorder of bleeding caused by deleterious mutations in the gene for clotting factor VIII. The large size of the factor VIII gene, the high frequency of de novo mutations and its tissue-specific expression complicate the detection of mutations. We have used a combination of RT-PCR of ectopic factor VIII transcripts and genomic DNA-PCRs to amplify the entire essential sequence of the factor VIII gene. This is followed by chemical mismatch cleavage analysis and direct sequencing in order to facilitate a comprehensive search for mutations. We describe the characterization of nine potentially pathogenic mutations, six of which are novel. In each case, a correlation of the genotype with the observed phenotype is presented. In order to evaluate the pathogenicity of the five missense mutations detected, we have analyzed them for evolutionary sequence conservation and for their involvement of sequence motifs catalogued in the PROSITE database of protein sites and patterns.

  3. Idiopathic factor VIII inhibitor autoantibody in a man presented after accident.

    NARCIS (Netherlands)

    Mansouritorghabeh, H.; Lak, M.; Heerde, W.L. van


    Acquired hemophilia A is a rare but severe autoimmune bleeding disorder caused by autoantibodies against factor VIII activity and is a potentially life-threatening hemorrhagic disorder. The incidence of acquired hemophilia A has been estimated as 1.48 cases per million per year. The overall rate of

  4. Factor VIII and von Willebrand factor co-delivery by endothelial cells

    NARCIS (Netherlands)

    Bouwens, E.A.M.|info:eu-repo/dai/nl/314061894


    A defect in coagulation factor VIII (FVIII) results in the inherited bleeding disorder hemophilia A. Current treatment of hemophilia A is hampered by the need of frequent administration of costly FVIII products. Therefore gene therapy is an attractive alternative for protein replacement to treat

  5. Living in a physical world VIII. Gravity and life in water

    Indian Academy of Sciences (India)


    Jul 31, 2006 ... Home; Journals; Journal of Biosciences; Volume 31; Issue 3. Living in a physical world VIII. Gravity and life in water. Steven Vogel. Series Volume 31 Issue 3 September 2006 pp 309-322. Fulltext. Click here to view fulltext PDF. Permanent link: ...

  6. Visualizing the Life and Legacy of Henry VIII: Guiding Students with Eight Types of Graphic Organizers (United States)

    Gallavan, Nancy P.; Kottler, Ellen


    Delving into the life and legacy of Henry VIII is both complex and captivating. People seem compelled to learn more abut his critical contributions and controversial conduct that range from the significant to the scandalous. Reflecting on the history of the world would be incomplete without investigating the events and escapades associated with…

  7. Quark matter coupled to domain walls in Bianchi types II, VIII and IX ...

    Indian Academy of Sciences (India)

    In this study of Bianchi types II, VIII and IX Universes, quark matter coupled to domain walls in the ... The self-bound state appears to be at ρ ... The observations suggest that the Hubble expansion of the Universe ... Taking motivation from.

  8. Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells

    NARCIS (Netherlands)

    van den Biggelaar, M.; Bouwens, E.A.M.; Kootstra, N.A.; Hebbel, R.P.; Voorberg, J.; Mertens, K.


    Background Gene therapy provides an attractive alternative for protein replacement therapy in hemophilia A patients. Recent studies have shown the potential benefit of directing factor (F)VIII gene delivery to cells that also express its natural carrier protein von Willebrand factor (VWF). In this

  9. Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells

    NARCIS (Netherlands)

    van den Biggelaar, Maartje; Bouwens, Eveline A. M.; Kootstra, Neeltje A.; Hebbel, Robert P.; Voorberg, Jan; Mertens, Koen


    Gene therapy provides an attractive alternative for protein replacement therapy in hemophilia A patients. Recent studies have shown the potential benefit of directing factor (F)VIII gene delivery to cells that also express its natural carrier protein von Willebrand factor (VWF). In this study, we

  10. Successful Pregnancy in a Patient with Combined Deficiency of Factor V and Factor VIII. (United States)

    El Adib, Ahmed Ghassan; Majdi, Farah; Dilai, Mohamed Othmane; Asmouki, Hamid; Bassir, Ahlam; Harou, Karam; Soumani, Abderraouf; Younous, Said; Mahmal, Lahoucine


    Inherited combined factor V and factor VIII deficiency (F5F8D) is autosomal recessive transmission disorder. Epistaxis, postsurgical bleeding, and menorrhagia are the most common symptoms. The risk of miscarriage and placental abruption is consequent. We report a case of successful pregnancy in a patient with F5F8D. 20-year-old woman, born of consanguineous parents, third gestate, first parity, two miscarriages, admitted for child birth of a spontaneous pregnancy estimated at 38 weeks and was diagnosed with F5F8D. At admission, patient was hemodynamically stable, with good obstetric conditions. The biologic results showed low levels of PT (52%), factor V (7%), and factor VIII (5%), and the activated partial thromboplastin time was prolonged (68,6%). Parturient was admitted in intensive care unit, maternal and fetal monitoring was performed. Fresh frozen plasma (FFP) and factor VIII concentrates were perfused at the induction of labor. Analgesia used fentanyl titration. The delivery gave birth to a newborn male, with Apgar 10/10 and 3000 g. The puerperium was simple without any important bleeding. Laboratory tests for the newborn were acceptable. Little literature is available on this subject and there are no guidelines available concerning pregnancy; we chose to prescribe a combination of factor VIII concentrate and FFP in pre-, per- and postpartum. The same protocol was successfully used in a patient before dental extraction and prostatectomy. Vaginal delivery is possible, as our case. Management by multidisciplinary team is recommended.

  11. Glioneuronal Heterotopia Presenting As a Cerebellopontine angle Tumor of the cranial Nerve VIII, Case Report. (United States)

    Peris-Celda, M; Giannini, C; Diehn, F E; Eckel, L J; Neff, B A; Van Gompel, J J


    Vestibular schwannomas and meningiomas account for the great majority of lesions arising in the cerebellopontine angle (CPA). In this report, we present a case of glioneuronal heterotopia, also known as glioneuronal hamartoma, arising from the VIII cranial nerve, which is an extremely uncommon lesion. Important radiologic and surgical aspects are reviewed, which may help in early recognition and intraoperative decision making when these lesions are encountered. A healthy 29-year-old female presented with intermittent right facial numbness. Magnetic resonance imaging (MRI) showed an incidental minimally enhancing cerebellopontine angle lesion on the right VII-VIII cranial nerve complex. The patient declined serial observation and opted for operative intervention for resection. Intraoperatively, the lesion resembled neural tissue and was continuous with the VIII cranial nerve. Pathological analysis demonstrated mature glioneuronal tissue consistent with hamartomatous brain tissue. The patient maintained normal hearing and facial nerve function after surgery. Radiologic, surgical and pathological characteristics are described. Ectopic glioneuronal tissue of the VIII cranial nerve is a rare non-neoplastic lesion, and should be considered in the differential diagnosis of unusual appearing intracanalicular and cerebellopontine angle lesions. The congenital and benign nature of this entity makes observation a valid option for these cases, although they are so infrequent that they are often presumptively managed as vestibular schwannomas. Attempts to radically resect these lesions may result in higher rates of hearing loss or facial palsy due to their continuity with the cranial nerves. Copyright © 2018 Elsevier Inc. All rights reserved.

  12. Home therapy with continuous infusion of factor VIII after minor surgery or serious haemorrhage. (United States)

    Varon, D; Schulman, S; Bashari, D; Martinowitz, U


    Administration of factor VIII (F VIII) concentrates by continuous infusion is now routinely used at several haemophilia centers but almost exclusively for hospitalized patients. We evaluated various aspects of home therapy with continuous infusion of an immunoaffinity purified F VIII concentrate (Monoclate P®, Armour) in patients who would normally have been treated with high doses in bolus injections or with continuous infusion as in-patients. Twenty haemophilia A patients, eight after minor surgery and 12 for serious haemorrhage, received continuous infusion with undiluted F VIII by a minipump for a mean of 0.9 days in the hospital, followed by 3.3 days at home. Infusion bags were exchanged every 2.5 days. No haemorrhagic complications occurred, and five haemorrhages that had been resistant to treatment with bolus injections responded promptly to the continuous infusion. There were no technical problems and patient compliance and acceptance was good. We find this mode of therapy safe, efficacious and convenient for the patients as well as for the staff.

  13. Synthesization of the Ar VIII 3s-3p beam-foil decay curve

    International Nuclear Information System (INIS)

    Lindgaard, A.; Veje, E.


    The beam-foil decay curve for the 3s-3p transition in Ar VIII has been simulated from experimentally determined relative initial level populations and transition probabilities calculated in the numerical Coulomb approximation. Good agreement is observed between simulated and measured decay curves. A discussion of the simulation is given. (Auth.)

  14. Quark matter coupled to domain walls in Bianchi types II, VIII and IX ...

    Indian Academy of Sciences (India)

    In this study of Bianchi types II, VIII and IX Universes, quark matter coupled to domain walls in the context of general relativity are explored. To obtain deterministic solution of the Einstein's field equations, various techniques are adopted. The features of the obtained solution are discussed.

  15. Chaos in long-term behavior of some Bianchi-type VIII models

    Energy Technology Data Exchange (ETDEWEB)

    Halpern, P


    The long-term behavior of Bianchi-type VIII models with three different types of stress-energy tensors are examined and compared. The vacuum model, a matter-filled model, and a model with an electromagnetic field are considered. In each case the existence of chaotic behavior and transitions to chaotic behavior are discussed.

  16. Absorption signatures of warm-hot gas at low redshift : Ne VIII

    NARCIS (Netherlands)

    Tepper-García, T


    At z {lt} 1 a large fraction of the baryons is thought to reside in diffuse gas that has been shock-heated to high temperatures (10$^{5}$-10$^{6}$ K). Absorption by the 770.41, 780.32 å doublet of Ne VIII in quasar spectra represents a unique tool to study this elusive warm-hot phase. We have

  17. In vivo recovery and safety of human factor VIII product AAFACT in patients with haemophilia A

    NARCIS (Netherlands)

    Vossebeld, P. J. M.; Tissing, M. H.; van den Berg, H. M.; Leebeek, F. W. G.; de Goede-Bolder, A.; Novakova, I. R. O.; Gerrits, W. B. J.; Peters, M.; Koopman, M. M. W.; Faber, A.; Hiemstra, H.; Grob, P.; Strengers, P. F. W.


    AAFACT, a monoclonal purified, solvent/detergent treated human plasma-derived coagulation factor VIII concentrate obtained from plasma of voluntary, non-remunerated blood donors, is manufactured and marketed in the Netherlands by Sanquin Plasma Products since 1995. In a postmarketing surveillance

  18. Safety and Efficacy of BAY 94-9027, a Prolonged-Half-Life Factor VIII

    DEFF Research Database (Denmark)

    Reding, M T; Ng, H J; Poulsen, Lone Hvitfeldt


    BACKGROUND: BAY 94-9027 is a B-domain-deleted prolonged-half-life recombinant factor VIII (FVIII) conjugates in a site-specific manner with polyethylene glycol. OBJECTIVE: Assess efficacy and safety of BAY 94-9027 for prophylaxis and treatment of bleeds in patients with severe hemophilia A PATIEN...

  19. Lithium ionophore VIII as an extraordinarily effective receptor for the strontium cation: Experimental and theoretical study

    Czech Academy of Sciences Publication Activity Database

    Makrlík, E.; Novák, Vít; Vaňura, P.; Bouř, Petr


    Roč. 1061, Mar 5 (2014), s. 110-113 ISSN 0022-2860 Institutional support: RVO:61388963 Keywords : strontium cation * lithium ionophore VIII * complexation * extraction and stability constants * DFT calculations * structures Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.602, year: 2014

  20. Complexation of the cesium cation with lithium ionophore VIII: extraction and DFT study

    Czech Academy of Sciences Publication Activity Database

    Makrlík, E.; Novák, Vít; Vaňura, P.; Bouř, Petr


    Roč. 298, č. 3 (2013), s. 2065-2068 ISSN 0236-5731 Institutional support: RVO:61388963 Keywords : cesium cation * lithium ionophore VIII * complexation * extraction and stability constants * water-nitrobenzene system * DFT calculations * structures Subject RIV: CB - Analytical Chemistry , Separation Impact factor: 1.415, year: 2013


    Directory of Open Access Journals (Sweden)

    Putri Athirah Azis


    Full Text Available The study aims at examining (1 the correlation of learning interest towards learning result of grade students, (2 the correlation of learning motivation towards learning result of grade students, (3 the correlation of students attitude towards learning result, (4 the correlationof interest, learning motivation, and attitude collaboratively towards learning result. The study is an ex post facto. The population of the study was grade VIII at SMPN 13 Makassar. Samples were 105 students taken by employing random sampling technique. Data were collected through questionnaire and documentation. Data were analyzed using regression test. The result of study reveal that (1 there is significant correlation (p<0,01 of interest towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,718 and its effectiveness contribution (R2 is 51,5%, (2 there is significant correlation (p<0,01 of motivation towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,775 and its effectiveness contribution (R2 is 60,1%, (3 there is significant correlation (p<0,01 of attitude towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,737 and its effectiveness contribution (R2 is 54,4%, (4 there is significant correlation (p<0,01 of interest, motivation and attitude collaboratively towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,861 and its effectiveness contribution (R2 is 74,1%,

  2. VIII Olimpíada Brasileira de Astronomia e Astronáutica (United States)

    Garcia Canalle, João Batista; Villas da Rocha, Jaime Fernando; Wuensche de Souza, Carlos Alexandre; Pereira Ortiz, Roberto; Aguilera, Nuricel Villalonga; Padilha, Maria De Fátima Catta Preta; Pessoa Filho, José Bezerra; Soares Rodrigues, Ivette Maria


    Neste trabalho apresentamos as motivações pelas quais organizamos, em conjunto, pela primeira vez, a Olimpíada Brasileira de Astronomia incluindo a Astronáutica, em colaboração com a Agência Espacial Brasileira. Esta ampliação contribuiu para atrair ainda mais alunos, professores, escolas e patrocinadores para participarem desta Olimpíada. Em 2005 participaram da VIII Olimpíada Brasileira de Astronomia e Astronáutica (VIII OBA) 187.726 alunos distribuídos por 3.229 escolas, pertencentes a todos os estados brasileiros, incluindo o Distrito Federal. O crescimento em número de alunos participantes foi 52,4% maior do que em 2004. Em abril de 2005 organizamos, em Itapecerica da Serra, SP, um curso para os 50 alunos previamente selecionados e participantes da VII OBA e ao final selecionamos, dentre eles, uma equipe de 5 alunos, os quais representaram o Brasil na X Olimpíada Internacional de Astronomia, na China, em outubro de 2005. Ganhamos, pela primeira vez, uma medalha de ouro naquele evento. Em Agosto de 2005, organizamos a VIII Escola de Agosto para 50 alunos e respectivos professores, em Águas de Lindóia, SP, juntamente com a XXXI reunião anual da Sociedade Astronômica Brasileira (SAB). Em novembro de 2005 realizamos a I Jornada Espacial, em São José dos Campos, com 22 alunos e 22 professores selecionados dentre os participantes que melhores resultados obtiveram nas questões de Astronáutica da VIII OBA. Neste trabalho detalhamos os resultados da VIII OBA bem como as ações subseqüentes.

  3. Specific membrane binding of factor VIII is mediated by O-phospho-L-serine, a moiety of phosphatidylserine. (United States)

    Gilbert, G E; Drinkwater, D


    Phosphatidylserine, a negatively charged lipid, is exposed on the platelet membrane following cell stimulation, correlating with the expression of factor VIII receptors. We have explored the importance of the negative electrostatic potential of phosphatidylserine vs chemical moieties of phosphatidylserine for specific membrane binding of factor VIII. Fluorescein-labeled factor VIII bound to membranes containing 15% phosphatidic acid, a negatively charged phospholipid, with low affinity compared to phosphatidylserine-containing membranes. Binding was not specific as it was inhibited by other proteins in plasma. Factor VIII bound to membranes containing 10% phosphatidylserine in spite of a varying net charge provided by 0-15% stearylamine, a positively charged lipid. The soluble phosphatidylserine moiety, O-phospho-L-serine, inhibited factor VIII binding to phosphatidylserine-containing membranes with a Ki of 20 mM, but the stereoisomer, O-phospho-D-serine, was 5-fold less effective. Furthermore, binding of factor VIII to membranes containing synthetic phosphatidyl-D-serine was 5-fold less than binding to membranes containing phosphatidyl-L-serine. Membranes containing synthetic phosphatidyl-L-homoserine, differing from phosphatidylserine by a single methylene, supported high-affinity binding, but it was not specific as factor VIII was displaced by other plasma proteins. O-Phospho-L-serine also inhibited the binding of factor VIII to platelet-derived microparticles with a Ki of 20 mM, and the stereoisomer was 4-fold less effective. These results indicate that membrane binding of factor VIII is mediated by a stereoselective recognition O-phospho-L-serine of phosphatidylserine and that negative electrostatic potential is of lesser importance.

  4. Population pharmacokinetics of recombinant coagulation factor VIII-SingleChain in patients with severe hemophilia A. (United States)

    Zhang, Y; Roberts, J; Tortorici, M; Veldman, A; St Ledger, K; Feussner, A; Sidhu, J


    Essentials rVIII-SingleChain is a unique recombinant factor VIII (FVIII) molecule. A population pharmacokinetic model was based on FVIII activity of severe hemophilia A patients. The model was used to simulate factor VIII activity-time profiles for various dosing scenarios. The model supports prolonged dosing of rVIII-SingleChain with intervals of up to twice per week. Background Single-chain recombinant coagulation factor VIII (rVIII-SingleChain) is a unique recombinant coagulation factor VIII molecule. Objectives To: (i) characterize the population pharmacokinetics (PK) of rVIII-SingleChain in patients with severe hemophilia A; (ii) identify correlates of variability in rVIII-SingleChain PK; and (iii) simulate various dosing scenarios of rVIII-SingleChain. Patients/Methods A population PK model was developed, based on FVIII activity levels of 130 patients with severe hemophilia A (n = 91 for ≥ 12-65 years; n = 39 for  85% and > 93% of patients were predicted to maintain FVIII activity level above 1 IU dL -1 , at all times with three-times-weekly dosing (given on days 0, 2, and 4.5) at the lowest (20 IU kg -1 ) and highest (50 IU kg -1 ) doses, respectively. For twice weekly dosing (days 0 and 3.5) of 50 IU kg -1 rVIII-SingleChain, 62-80% of patients across all ages were predicted to maintain a FVIII activity level above 1 IU dL -1 at day 7. Conclusions The population PK model adequately characterized rVIII-SingleChain PK, and the model can be utilized to simulate FVIII activity-time profiles for various dosing scenarios. © 2017 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.

  5. Intelligent Mission Controller Node

    National Research Council Canada - National Science Library

    Perme, David


    The goal of the Intelligent Mission Controller Node (IMCN) project was to improve the process of translating mission taskings between real-world Command, Control, Communications, Computers, and Intelligence (C41...

  6. Critical Robotic Lunar Missions (United States)

    Plescia, J. B.


    Perhaps the most critical missions to understanding lunar history are in situ dating and network missions. These would constrain the volcanic and thermal history and interior structure. These data would better constrain lunar evolution models.

  7. Dukovany ASSET mission preparation

    Energy Technology Data Exchange (ETDEWEB)

    Kouklik, I [NPP Dukovany (Czech Republic)


    We are in the final stages of the Dukovany ASSET mission 1996 preparation. I would like to present some of our recent experiences. Maybe they would be helpful to other plants, that host ASSET missions in future.

  8. Dukovany ASSET mission preparation

    International Nuclear Information System (INIS)

    Kouklik, I.


    We are in the final stages of the Dukovany ASSET mission 1996 preparation. I would like to present some of our recent experiences. Maybe they would be helpful to other plants, that host ASSET missions in future

  9. Mission operations management (United States)

    Rocco, David A.


    Redefining the approach and philosophy that operations management uses to define, develop, and implement space missions will be a central element in achieving high efficiency mission operations for the future. The goal of a cost effective space operations program cannot be realized if the attitudes and methodologies we currently employ to plan, develop, and manage space missions do not change. A management philosophy that is in synch with the environment in terms of budget, technology, and science objectives must be developed. Changing our basic perception of mission operations will require a shift in the way we view the mission. This requires a transition from current practices of viewing the mission as a unique end product, to a 'mission development concept' built on the visualization of the end-to-end mission. To achieve this change we must define realistic mission success criteria and develop pragmatic approaches to achieve our goals. Custom mission development for all but the largest and most unique programs is not practical in the current budget environment, and we simply do not have the resources to implement all of our planned science programs. We need to shift our management focus to allow us the opportunity make use of methodologies and approaches which are based on common building blocks that can be utilized in the space, ground, and mission unique segments of all missions.

  10. Computer graphics aid mission operations. [NASA missions (United States)

    Jeletic, James F.


    The application of computer graphics techniques in NASA space missions is reviewed. Telemetric monitoring of the Space Shuttle and its components is discussed, noting the use of computer graphics for real-time visualization problems in the retrieval and repair of the Solar Maximum Mission. The use of the world map display for determining a spacecraft's location above the earth and the problem of verifying the relative position and orientation of spacecraft to celestial bodies are examined. The Flight Dynamics/STS Three-dimensional Monitoring System and the Trajectroy Computations and Orbital Products System world map display are described, emphasizing Space Shuttle applications. Also, consideration is given to the development of monitoring systems such as the Shuttle Payloads Mission Monitoring System and the Attitude Heads-Up Display and the use of the NASA-Goddard Two-dimensional Graphics Monitoring System during Shuttle missions and to support the Hubble Space Telescope.

  11. Compact invariant sets of the Bianchi VIII and Bianchi IX Hamiltonian systems

    International Nuclear Information System (INIS)

    Starkov, Konstantin E.


    In this Letter we prove that all compact invariant sets of the Bianchi VIII Hamiltonian system are contained in the set described by several simple linear equalities and inequalities. Moreover, we describe invariant domains in which the phase flow of this system has no recurrence property and show that there are no periodic orbits and neither homoclinic, nor heteroclinic orbits contained in the zero level set of its Hamiltonian. Similar results are obtained for the Bianchi IX Hamiltonian system. -- Highlights: → Zero level set of Hamiltonian of Bianchi VIII/IX systems contains no periodic orbits. → Similar conditions for homoclinic/heteroclinic orbits are given. → General nonexistence conditions of compact invariant sets are got.

  12. Compact invariant sets of the Bianchi VIII and Bianchi IX Hamiltonian systems

    Energy Technology Data Exchange (ETDEWEB)

    Starkov, Konstantin E., E-mail: [CITEDI-IPN, Av. del Parque 1310, Mesa de Otay, Tijuana, BC (Mexico)


    In this Letter we prove that all compact invariant sets of the Bianchi VIII Hamiltonian system are contained in the set described by several simple linear equalities and inequalities. Moreover, we describe invariant domains in which the phase flow of this system has no recurrence property and show that there are no periodic orbits and neither homoclinic, nor heteroclinic orbits contained in the zero level set of its Hamiltonian. Similar results are obtained for the Bianchi IX Hamiltonian system. -- Highlights: → Zero level set of Hamiltonian of Bianchi VIII/IX systems contains no periodic orbits. → Similar conditions for homoclinic/heteroclinic orbits are given. → General nonexistence conditions of compact invariant sets are got.

  13. Haemophilia A: Database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene

    Energy Technology Data Exchange (ETDEWEB)

    Tuddenham, E.G.D. (Clinical Research Centre, Harrow (United Kingdom)); Cooper, D.N. (Thrombosis Research Inst., London (United Kingdom)); Gitschier, J. (Univ. of California, San Francisco (United States)); Higuchi, M.; Kazazian, H.H.; Antonarakis, S.E. (Johns Hopkins Univ., Baltimore (United States)); Hoyer, L.W. (American Red Cross, Rockville (United States)); Yoshioka, A. (Nara Medical Coll., Kashihara City (Japan)); Peake, I.R. (Royal Hallamshire Hospital, Sheffield (United Kingdom)); Schwaab, R. (Inst. fuer Klinische Biochemie der Univ. Bonn (West Germany)); Lavergne, J.M. (Hopital de Bicetre (France)); Giannelli, F. (Guy' s Hospital, London (United Kingdom))


    Mutations at the factor VIII gene locus causing Haemophilia A have now been identified in many patients from a many ethnic groups. Earlier studies used biased methods which detected repetitive mutations at a few CG dinucleotides. More recently rapid gene scanning methods have uncovered an extreme diversity of mutations. Over 80 different point mutations, 6 insertions, 7 small deletions, and 60 large deletions have been characterized. Repetitive mutation has been proved for at least 16 CpG sites. All nonsense mutations cause severe disease. Most missense mutations appear to cause instability of the protein, but some are associated with production of dysfunctional factor VIII molecules, thereby localizing functionally critical regions of the cofactor. Variable phenotype has been observed in association with three of the latter class of genotype. This catalogue of gene lesions in Haemophilia A will be updated annually.

  14. Detection of Intracellular Factor VIII Protein in Peripheral Blood Mononuclear Cells by Flow Cytometry

    Directory of Open Access Journals (Sweden)

    Gouri Shankar Pandey


    Full Text Available Flow cytometry is widely used in cancer research for diagnosis, detection of minimal residual disease, as well as immune monitoring and profiling following immunotherapy. Detection of specific host proteins for diagnosis predominantly uses quantitative PCR and western blotting assays. In this study, we optimized a flow cytometry-based detection assay for Factor VIII protein in peripheral blood mononuclear cells (PBMCs. An indirect intracellular staining (ICS method was standardized using monoclonal antibodies to different domains of human Factor VIII protein. The FVIII protein expression level was estimated by calculating the mean and median fluorescence intensities (MFI values for each monoclonal antibody. ICS staining of transiently transfected cell lines supported the method's specificity. Intracellular FVIII protein expression was also detected by the monoclonal antibodies used in the study in PBMCs of five blood donors. In summary, our data suggest that intracellular FVIII detection in PBMCs of hemophilia A patients can be a rapid and reliable method to detect intracellular FVIII levels.



    Apri Dwi Astuti


    Kemandirian belajar membantu siswa untuk bertanggung jawab dan menumbuhkan kesadaran belajar. Penggunaan uang saku menumbuhkan jiwa mandiri, jujur dan komitmen. Adapun hasil observasi awal menunjukkan masih ada siswa kels VII dan VIII SMP Semesta untuk kompetensi dasar ekonomi dibawah KKM. Tujuan penelitian ini untuk mengetahui pengaruh kemandirian belajar dn penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta. Populasi penelitian ini adalah ...

  16. Construction of a mouse model of factor VIII deficiency by gene targeting

    Energy Technology Data Exchange (ETDEWEB)

    Bi, L.; Lawler, A.; Gearhart, J. [Univ. of Pennsylvania School of Medicine, Philadelphia, PA (United States)] [and others


    To develop a small animal model of hemophilia A for gene therapy experiments, we set out to construct a mouse model for factor VIII deficiency by gene targeting. First, we screened a mouse liver cDNA library using a human FVIII cDNA probe. We cloned a 2.6 Kb partial mouse factor VIII cDNA which extends from 800 base pairs of the 3{prime} end of exon 14 to the 5{prime} end of exon 26. A mouse genomic library made from strain 129 was then screened to obtain genomic fragments covering the exons desired for homologous recombination. Two genomic clones were obtained, and one covering exon 15 through 22 was used for gene targeting. To make gene targeting constructs, a 5.8 Kb genomic DNA fragment covering exons 15 to 19 of the mouse FVIII gene was subcloned, and the neo expression cassette was inserted into exons 16 and 17 separately by different strategies. These two constructs were named MFVIIIC-16 and MFVIIIC-17. The constructs were linearized and transfected into strain 129 mouse ES cells by electroporation. Factor VIII gene-knockout ES cell lines were selected by G-418 and screened by genomic Southern blots. Eight exon 16 targeted cell lines and five exon 17 targeted cell lines were obtained. Three cell lines from each construct were injected into blastocysts and surgically transferred into foster mothers. Multiple chimeric mice with 70-90% hair color derived from the ES-cell genotype were seen with both constructs. Germ line transmission of the ES-cell genotype has been obtained for the MFVIIIC-16 construct, and multiple hemophilia A carrier females have been identified. Factor VIII-deficient males will be conceived soon.

  17. Structural Mimics of the [Fe]-Hydrogenase: A Complete Set for Group VIII Metals. (United States)

    Barik, Chandan Kr; Ganguly, Rakesh; Li, Yongxin; Leong, Weng Kee


    A set of structural mimics of the [Fe]-hydrogenase active site comprising all the group VIII metals, viz., [M(2-NHC(O)C 5 H 4 N)(CO) 2 (2-S-C 5 H 4 N)], has been synthesized. They exist as a mixture of isomers in solution, and the relative stability of the isomers depends on the nature of the metal and the substituent at the 6-position of the pyridine ligand.

  18. Historical intensity VIII earthquakes along the Rhone valley (Valais, Switzerland): primary and secondary effects

    Energy Technology Data Exchange (ETDEWEB)

    Fritsche, S.; Faeh, D.; Schwarz-Zanetti, G.


    In recent years the upper Rhone Valley has been one of the most intensively investigated regions by the Swiss Seismological Service. The high seismicity in the region encourages research in the seismological field and one main focus has been historical seismology. This report presents the state of the art of our historical investigations by giving an overview of the effects of four damaging earthquakes with intensity larger than VII, for which a fairly large number of documents could be found and analyzed. The overview includes the events of 1584 (Aigle, epicentral intensity VIII), 1755 (Brig, epicentral intensity VIII), 1855 (Visp, epicentral intensity VIII), and 1946 (Sierre, epicentral intensity VIII for the main shock and intensity VII for the largest aftershock). The paper focuses mainly on primary and secondary effects in the epicentral region, providing the key data and a general characterization of the event. Generally, primary effects such as the reaction of the population and impact on buildings took more focus in the past. Thus building damage is more frequently described in historic documents. However, we also found a number of sources describing secondary effects such as landslides, snow avalanches, and liquefaction. Since the sources may be useful, we include citations of these documents. The 1584 Aigle event, for example, produced exceptional movements in the Lake of Geneva, which can be explained by an expanded sub aquatic slide with resultant tsunami and seiche. The strongest of the aftershocks of the 1584 event triggered a destructive landslide covering the villages Corbeyrier and Yvorne, Vaud. All macroseismic data on the discussed events are accessible through the web page of the Swiss Seismological Service ( (authors)

  19. VIII All-Russian symposium on molecular liquid chromatography and capillary electrophoresis. Program. Summary of reports

    International Nuclear Information System (INIS)


    Program and summary of reports of the VIII All-Russian symposium on molecular liquid chromatography and capillary electrophoresis are performed. The meeting took place 15-19 October, 2001 in Moscow. Many problems of liquid and ion exchange chromatography, capillary electrophoresis, thin-layer chromatography have been discussed extensively. Reports covering properties of sorbents and devices for chromatography are incorporated in the collection [ru

  20. Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models


    Siner, Joshua I.; Samelson-Jones, Benjamin J.; Crudele, Julie M.; French, Robert A.; Lee, Benjamin J.; Zhou, Shanzhen; Merricks, Elizabeth; Raymer, Robin; Nichols, Timothy C.; Camire, Rodney M.; Arruda, Valder R.


    Processing by the proprotein convertase furin is believed to be critical for the biological activity of multiple proteins involved in hemostasis, including coagulation factor VIII (FVIII). This belief prompted the retention of the furin recognition motif (amino acids 1645–1648) in the design of B-domain–deleted FVIII (FVIII-BDD) products in current clinical use and in the drug development pipeline, as well as in experimental FVIII gene therapy strategies. Here, we report that processing by fu...

  1. Structural characterization of the novel aminoglycoside phosphotransferase AphVIII from Streptomyces rimosus with enzymatic activity modulated by phosphorylation

    Energy Technology Data Exchange (ETDEWEB)

    Boyko, Konstantin M., E-mail: [Bach Institute of Biochemistry, Federal Research Centre of Biotechnology of the Russian Academy of Sciences, Leninsky Prospekt. 33, Bld. 2, 119071, Moscow (Russian Federation); National Research Center “Kurchatov Institute”, Kurchatov Complex of NBICS-technologies, Akad. Kurchatova sqr., 1, Moscow, 123182 (Russian Federation); Gorbacheva, Marina A.; Korzhenevskiy, Dmitry A. [National Research Center “Kurchatov Institute”, Kurchatov Complex of NBICS-technologies, Akad. Kurchatova sqr., 1, Moscow, 123182 (Russian Federation); Alekseeva, Maria G.; Mavletova, Dilara A.; Zakharevich, Natalia V.; Elizarov, Sergey M.; Rudakova, Natalia N.; Danilenko, Valery N. [Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina str. 3, Moscow, 119333 (Russian Federation); Popov, Vladimir O. [Bach Institute of Biochemistry, Federal Research Centre of Biotechnology of the Russian Academy of Sciences, Leninsky Prospekt. 33, Bld. 2, 119071, Moscow (Russian Federation); National Research Center “Kurchatov Institute”, Kurchatov Complex of NBICS-technologies, Akad. Kurchatova sqr., 1, Moscow, 123182 (Russian Federation)


    Aminoglycoside phosphotransferases represent a broad class of enzymes that promote bacterial resistance to aminoglycoside antibiotics via the phosphorylation of hydroxyl groups in the latter. Here we report the spatial structure of the 3′-aminoglycoside phosphotransferase of novel VIII class (AphVIII) solved by X-ray diffraction method with a resolution of 2.15 Å. Deep analysis of APHVIII structure and its comparison with known structures of aminoglycoside phosphotransferases of various types reveals that AphVIII has a typical two-domain fold and, however, possesses some unique characteristics that distinguish the enzyme from its known homologues. The most important difference is the presence of the activation loop with unique Ser146 residue. We demonstrate that in the apo-state of the enzyme the activation loop does not interact with other parts of the enzyme and seems to adopt catalytically competent state only after substrate binding. - Highlights: • 3D structure of the novel aminoglycoside phosphotransferase AphVIII was obtained. • AphVIII activation loop is clearly identified in the electron density. • AphVIII has some unique structural features in its substrate C-ring binding pocket.


    Directory of Open Access Journals (Sweden)

    Omega Rianda Rustian


    This study is based on interviews conducted in one of the BK school teacher. This study aimed to determine the perception class VIII student perceptions on adolescent reproductive health and sexually transmitted diseases in SMP Islam Sultan Agung 1 Semarang. The method used in this research is descriptive quantitative survey methods. Population in this research is class VIII SMP Islam Sultan Agung 1 Semarang totaling 151 students with a sampling technique used is accidental to obtain a sample of 60. Data collection tools in the form of a psychological scale with data analysis techniques using descriptive analysis percentage. The average result of students' perceptions on adolescent reproductive health in the high category (74% and perceptions of students about sexually transmitted diseases in the very high category (76%. That class VIII SMP Islam Sultan Agung 1 Semarang already have an idea of the meaning of adolescent reproductive health is a state of good health both physically healthy, functioning, as well as reproductive performance in adolescent and the  meaning of sexually transmitted diseases are caused by viruses, parasites, or function as a result of sexual intercourse.

  3. A close insight to factor VIII inhibitor in the congenital hemophilia A. (United States)

    Tabriznia-Tabrizi, Shamsoreza; Gholampour, Marzie; Mansouritorghabeh, Hassan


    Hemophilia A (HA) has an X-linked pattern of inheritance and is the most common of the hemorrhagic disorders. HA is caused by a decreased or deficiency of the functional clotting factor VIII (FVIII) and effects 1 in 5000-10,000 male births. The common treatment for hemophilia is replacement therapy by plasma-derived or recombinant FVIII. Approximately 20-30% of people with a severe type of HA develop an inhibitor and this phenomenon is the main challenge in the management of these patients. Genetic factors and environmental determinants contribute to inhibitor development. Here, the roles of various genetic and environmental factors such as the type of FVIII concentrate used, the number of exposure days, and peak treatment time will be discussed in detail. It seems this information is helpful for hematologists. A literature review was done in January 2016 on PubMed and Scopus using the following keywords:' h(a)emophilia A & factor VIII inhibitor', 'h(a)emophilia A & factor VIII alloantibody', 'h(a)emophilia A & inhibitor'. There was no time limitation; however, there was an English language limitation placed on the articles selected. Expert commentary: Influential genetic and environmental factors in developing inhibitors have been discussed. Most of the risk factors are related to previously untreated patients with hemophili.

  4. The STEREO Mission

    CERN Document Server


    The STEREO mission uses twin heliospheric orbiters to track solar disturbances from their initiation to 1 AU. This book documents the mission, its objectives, the spacecraft that execute it and the instruments that provide the measurements, both remote sensing and in situ. This mission promises to unlock many of the mysteries of how the Sun produces what has become to be known as space weather.

  5. VEGA Space Mission (United States)

    Moroz, V.; Murdin, P.


    VEGA (mission) is a combined spacecraft mission to VENUS and COMET HALLEY. It was launched in the USSR at the end of 1984. The mission consisted of two identical spacecraft VEGA 1 and VEGA 2. VEGA is an acronym built from the words `Venus' and `Halley' (`Galley' in Russian spelling). The basic design of the spacecraft was the same as has been used many times to deliver Soviet landers and orbiter...

  6. Factor VIII levels and the risk of pre-eclampsia, HELLP syndrome, pregnancy related hypertension and severe intrauterine growth retardation. (United States)

    Witsenburg, C P J; Rosendaal, F R; Middeldorp, J M; Van der Meer, F J M; Scherjon, S A


    Recently, acquired as well as genetic prothrombotic factors are associated with thrombotic events. These factors have also been related to conditions of uteroplacental insufficiency such as pre-eclampsia, HELLP syndrome and severe intrauterine growth restriction (IUGR). The aim of this study was to determine whether elevated factor VIII levels are associated with uteroplacental insufficiency, in particular pre-eclampsia, HELLP syndrome or pregnancy-induced hypertension and intrauterine growth retardation. Plasma samples of 75 women with a history of pregnancy complicated by pre-eclampsia, HELLP syndrome, pregnancy induced hypertension or intrauterine growth restriction were tested for factor VIII:C (FVIII:C) levels at a minimum of 10 weeks post-partum. Laboratory results were compared to factor VIII:C levels found in a healthy control group of 272 women. Mean factor VIII:C levels were similar at 123 IU/dl in both the patient group and the controls. In a logistic regression model, after adjusting for age and blood group, no effect of factor VIII:C levels on the risk of pregnancy complications was observed, with the exception of IUGR with (OR 2.9, CI 1.0-8.7) or without hypertension (OR 2.0, CI 0.7-6.4). If the elevated level of factor VIII would be the sole factor responsible for the increased risk observed, one would expect to find an effect of blood group on risk as well (blood group being an important determinant of FVIII:C). While no such effect could be shown a causal relationship between elevated levels of factor VIII and conditions of uteroplacental insufficiency such as pre-eclampsia, HELLP syndrome, pregnancy-induced hypertension and IUGR is not very likely.

  7. Mission of Mercy. (United States)

    Humenik, Mark


    Some dentists prefer solo charity work, but there is much to be said for collaboration within the profession in reaching out to those who are dentally underserved. Mission of Mercy (MOM) programs are regularly organized across the country for this purpose. This article describes the structure, reach, and personal satisfaction to be gained from such missions.

  8. Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex

    Energy Technology Data Exchange (ETDEWEB)

    Ngo, J.C.; Huang, M.; Roth, D.A.; Furie, B.C.; Furie, B. (Wyeth); (MBL)


    Factor VIII is a procofactor that plays a critical role in blood coagulation, and is missing or defective in hemophilia A. We determined the X-ray crystal structure of B domain-deleted human factor VIII. This protein is composed of five globular domains and contains one Ca{sup 2+} and two Cu{sup 2+} ions. The three homologous A domains form a triangular heterotrimer where the A1 and A3 domains serve as the base and interact with the C2 and C1 domains, respectively. The structurally homologous C1 and C2 domains reveal membrane binding features. Based on biochemical studies, a model of the factor IXa-factor VIIIa complex was constructed by in silico docking. Factor IXa wraps across the side of factor VIII, and an extended interface spans the factor VIII heavy and light chains. This model provides insight into the activation of factor VIII and the interaction of factor VIIIa with factor IXa on the membrane surface.

  9. Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex

    Energy Technology Data Exchange (ETDEWEB)

    Chi Ki Ngo,J.; Huang, M.; Roth, D.; Furie, B.; Furie, B.


    Factor VIII is a procofactor that plays a critical role in blood coagulation, and is missing or defective in hemophilia A. We determined the X-ray crystal structure of B domain-deleted human factor VIII. This protein is composed of five globular domains and contains one Ca(2+) and two Cu(2+) ions. The three homologous A domains form a triangular heterotrimer where the A1 and A3 domains serve as the base and interact with the C2 and C1 domains, respectively. The structurally homologous C1 and C2 domains reveal membrane binding features. Based on biochemical studies, a model of the factor IXa-factor VIIIa complex was constructed by in silico docking. Factor IXa wraps across the side of factor VIII, and an extended interface spans the factor VIII heavy and light chains. This model provides insight into the activation of factor VIII and the interaction of factor VIIIa with factor IXa on the membrane surface.

  10. Analysis of inversions in the factor VIII gene in Spanish hemophilia A patients and families

    Energy Technology Data Exchange (ETDEWEB)

    Domenech, M.; Tizzano, E.; Baiget, M. [Hospital de Sant Pau, Barcelona (Spain); Altisent, C. [Hospital Vall d`Hebron, Barcelona (Spain)


    Intron 22 is the largest intron of the factor VIII gene and contains a CpG island from which two additional transcripts originate. One of these transcripts corresponds to the F8A gene which have telomeric extragenic copies in the X chromosome. An inversion involving homologous recombination between the intragenic and the distal or proximal copies of the F8A gene has been recently described as a common cause of severe hemophilia A (HA). We analyzed intron 22 rearrangements in 195 HA patients (123 familial and 72 sporadic cases). According to factor VIII levels, our sample was classified as severe in 114 cases, moderate in 29 cases and mild in 52 cases. An intron 22 (F8A) probe was hybridized to Southern blots of BcII digested DNA obtained from peripheral blood. A clear pattern of altered bands identifies distal or proximal inversions. We detected an abnormal pattern identifying an inversion in 49 (25%) of the analyzed cases. 43% of severe HA patients (49 cases) showed an inversion. As expected, no inversion was found in the moderate and mild group of patients. We found a high proportion (78%) of the distal rearrangement. From 49 identified inversions, 33 were found in familial cases (27%), while the remaining 15 were detected in sporadic patients (22%) in support that this mutational event occurs with a similar frequency in familial or sporadic cases. In addition, we detected a significant tendency of distal inversion to occur more frequently in familial cases than in sporadic cases. Inhibitor development to factor VIII was documented in approximately 1/3 of the patients with inversion. The identification of such a frequent molecular event in severe hemophilia A patients has been applied in our families to carrier and prenatal diagnosis, to determine the origin of the mutation in the sporadic cases and to detect the presence of germinal mosaicism.


    Directory of Open Access Journals (Sweden)

    Venny Agustiani Mahardikawati


    Full Text Available 800x600 Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 Quality of human resources is very important to improve productivity. The worker productivity is correlated with nutritional status and health status. The objective of the research is to analyze physical activity, energy intake, nutritional status, of women workers at Tea Plantation PTPN VIII Bandung, West Java. The cross sectional design was used in this study to elaborate physical activity, nutritional status, and productivity of tea picker’s women. The criteria of study sample were tea picker’s women at cluster area of Malabar tea plantation of PTPN VIII Bandung, having infant and they were willing to be interviewed. The total number of 92 women sample was chosen randomly. Primary data consisted of physical activity recall (2x24 hours, food consumption recall (2x24 hours, anthropometry data (weight and height, and productivity (passage of tea sprout. Secondary data were included data of PT Perkebunan Nusantara VIII Bandung, West Java. The result showed that more than a half of samples having active or moderate physical activity level (PAL. The physical activity level of samples during work day (average PAL=1.87 was higher than holiday (average PAL=1.69 (p2362 kcal and 2134 kcal. The average energy adequacy level during workday and day off according to Schofield and Oxford equation were not significantly different, respectively 97,2% and 103,3%. The majority of samples had normal nutritional status, and 30.4% of the sample was overweight. The energy adequacy level according to Schofield and Oxford equation are related to nutritional status of women workers. Keywords: physical activity, energy expenditure, nutritional status, plantation women

  12. Prospects and Challenges of Implementing the Hydrographic Region VIII Basin Plan

    Directory of Open Access Journals (Sweden)

    Nathalia Silva Duarte


    Full Text Available The current “National Water Law” states that water resources plans must be elaborated by basins, states, and for the country. This essay discusses the water management process considering federal and state legislations and their interrelations, for the purpose of elucidating the gaps found in them , aiming at their applicability to the system of water resources management within the CBH- Macaé and Ostras scope. It also discusses the construction and evolution process of the above-mentioned committee, and developments in the implementation of the Basin Plan of Hydrographic Region VIII.

  13. Leonor Plantagenet y la consolidación castellana en el reinado de Alfonso VIII

    Directory of Open Access Journals (Sweden)

    Cerda, José Manuel


    Full Text Available The kingdom of Castile experienced a process of political and territorial consolidation between the death of Sancho III in 1158 and the Curia of Carrión de los Condes in 1188, leaving behind the troublesome minority of Alfonso VIII and the subordination to the kingdom of Leon, and thus becoming a dominant power within the peninsula, and one that achieved considerable success in the Reconquest. The following article is part of a biographical approach to Eleanor Plantagenet, queen consort of Alfonso VIII, and by means of a specifi c focus offers an analysis of the role played by the English queen in this process of political consolidation of Castile. As we approach the eighth centenary of her death, the life and work of this little-studied woman emerges as a testimony to the important diplomatic and cultural tasks assumed by queens in twelfth-century Europe.

    Desde la muerte de Sancho III en 1158 a la Curia de Carrión de los Condes en 1188, el reino castellano experimentó una consolidación política y territorial que dejó atrás la problemática minoría de Alfonso VIII y la subordinación al reino de León, que lo constituyó en un poder dominante dentro de la península y que logró un avance importante en la empresa reconquistadora. El presente trabajo es parte de un acercamiento biográfico a Leonor Plantagenet, consorte de Alfonso VIII, y que por medio de un enfoque particular ofrece un análisis de la incidencia que tuvo la reina inglesa en este proceso de afianzamiento político de Castilla. En las vísperas del octavo centenario de su muerte, la vida y obra de esta mujer hasta ahora poco estudiada, surge como un testimonio importante a la labor diplomática y cultural que asumían las reinas en la Europa del siglo XII.


    Directory of Open Access Journals (Sweden)

    Djumikasih Djumikasih


    Full Text Available Abstract This paper aims to identify and analyze what the juridical implications of the publication of the decision of the Constitutional Court No. 46/PUU-VIII / 2010 on Child Outside Marriage Deed which has been published by the Department of Population and Civil Registration prior to the establishment of the Constitutional Court's decision . The method used in this study is a normative juridical approach legislation. From the discussion, it can be concluded that the Constitutional Court 46/PUU-VIII/2010 Number of Tests on Article 43 paragraph ( 1 Marriage Act ( Act No. 1 of 1974 when viewed from the angle of legal certainty it will lead to legal certainty . But the decision will not have any juridical implications of the child's birth certificate that has been published outside of marriage and illegitimate child who was born before the date of February 17, 2012, as if enacted would be contrary to the principle of legality is interpreted Article 47 of the Law on the Constitutional Court and Article 28 ( i of the 1945 Constitution . Likewise, if the terms of the fairness and usefulness , especially for justice seekers / applicant , the timing of this decision is not fair and not useful , because although the Court granted the petition but the Constitutional Court can not be applied to her .   Key words: yuridical implication, birth certificate, children who are born outside of marriage   Abstrak   Tulisan ini bertujuan untuk mengetahui dan menganalisis apa implikasi yuridis dari terbitnya putusan MK Nomor 46/PUU-VIII/ 2010 terhadap Akta Anak Luar Kawin yang sudah diterbitkan oleh Dinas Kependudukan dan Catatan Sipil sebelum lahirnya putusan MK tersebut. Metode yang digunakan dalam penelitian ini adalah yuridis normative dengan pendekatan perundang-undangan. Dari pembahasan dapat disimpulkan bahwa Putusan MK Nomer 46/PUU-VIII/2010 tentang Pengujian terhadap Pasal 43 ayat (1 UU Perkawinan (UU NO 1 Tahun 1974 jika dilihat dari sudut kepastian

  15. Grotrian diagrams for highly ionized cobalt Co VIII through Co XXVII

    Energy Technology Data Exchange (ETDEWEB)

    Shirai, Toshizo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Sugar, J.; Wiese, W.L.


    Grotrian diagrams are presented to provide graphical overviews for 1,247 spectral lines of highly ionized cobalt, Co VIII through Co XXVII. In the usual diagram display such as that by Bashkin and Stoner (North-Holland, Amsterdam, 1975), the density of transitions is often too high to allow each transition to be drawn separately. Here in our modified diagrams, the transitions are also represented by lines connecting the upper and lower energy levels, but the lower energy levels are extended and repeated for successive configurations as needed. As a sequence, dense packing is avoided and all lines in a multiplet can be accommodated. (author)

  16. Comercio Internacional mediterráneo en el siglo VIII a.C.

    Directory of Open Access Journals (Sweden)

    Paloma Cabrera Bonet


    Full Text Available The VIII century B.C. saw, for the first time after the breakdown of the system in the Late Bronze Age, the revival of a true intemational trade at a growing scale, especíally protagonized by Phoenicians and Greeks. In this article we analyze sorne aspects of this phenomenon, from the Aegean to the Far West, which made possíble, through a vaste network of trading routes, a large multinational ínteractíon. We understand the international trade as a key factor in the proccess of economic, social and political changes of the Mediterranean areas submerged in this complex "world-system".

  17. Underground Test Area Subproject Phase I Data Analysis Task. Volume VIII - Risk Assessment Documentation Package

    Energy Technology Data Exchange (ETDEWEB)



    Volume VIII of the documentation for the Phase I Data Analysis Task performed in support of the current Regional Flow Model, Transport Model, and Risk Assessment for the Nevada Test Site Underground Test Area Subproject contains the risk assessment documentation. Because of the size and complexity of the model area, a considerable quantity of data was collected and analyzed in support of the modeling efforts. The data analysis task was consequently broken into eight subtasks, and descriptions of each subtask's activities are contained in one of the eight volumes that comprise the Phase I Data Analysis Documentation.

  18. Isidore of Seville and comici ueteres. Ad Isid., Orig. VIII 7.7

    Directory of Open Access Journals (Sweden)

    Krzysztof Rzepkowski


    Full Text Available In chapter 7 of book VIII of Etymologies dedicated to Roman poets (De poetis, Isidore draws a dividing line between the so-called ueteres and noui comici. Among ueteres he counts Plautus, Accius, Terentius, although Accius, according to our knowledge, composed only tragedies and can hardly be considered a comic playwright. In this paper I try to prove that all the palaeographic, phonetic, historical, and literary arguments speak in favour of emending in the discussed passage the peculiar «Accius» to the expected «Caecilius» (i.e. Caecilius Statius.

  19. Molecular characterization of a novel family VIII esterase from burkholderia multivorans UWC10

    CSIR Research Space (South Africa)

    Rashamuse, KJ


    Full Text Available et al., 1992). Here we report the cloning, purification, and 3D model of a novel family VIII esterase from Burkholderia multivorans UWC10. To our knowledge no report of esterolytic activity from B. multivorans is currently available. METHODOLOGY... stream_source_info Rashamuse1_2007_d.pdf.txt stream_content_type text/plain stream_size 9884 Content-Encoding UTF-8 stream_name Rashamuse1_2007_d.pdf.txt Content-Type text/plain; charset=UTF-8 Molecular Characterization...

  20. Estudo da articulação temporomandibular em camundongos deficientes de fator VIII


    Patricia do Socorro Queiroz Feio


    Resumo: A hemofilia é uma doença hemorrágica hereditária ligada ao cromossomo X, decorrente da ausência ou da baixa quantidade no plasma dos fatores de coagulação Fator VIII (hemofilia A) ou do Fator IX (hemofilia B). Clinicamente, a hemofilia se caracteriza por episódios recorrentes de sangramentos profundos, que podem ocorrer espontaneamente ou em decorrência de traumatismos. O sistema músculo-esquelético é freqüentemente afetado pelos eventos hemorrágicos nos pacientes portadores de hemofi...

  1. Influence of Problem Based Learning on Critical Thinking Skills and Competence Class VIII SMPN 1 Gunuang Omeh, 2016/2017 (United States)

    Aswan, D. M.; Lufri, L.; Sumarmin, R.


    This research intends to determine the effect of Problem Based Learning models on students' critical thinking skills and competences. This study was a quasi-experimental research. The population of the study was the students of class VIII SMPN 1 Subdistrict Gunuang Omeh. Random sample selection is done by randomizing the class. Sample class that was chosen VIII3 as an experimental class given that treatment study based on problems and class VIII1 as control class that treatment usually given study. Instrument that used to consist of critical thinking test, cognitive tests, observation sheet of affective and psychomotor. Independent t-test and Mann Whitney U test was used for the analysis. Results showed that there was significant difference (sig competences.

  2. Role of VI/II ratio on the growth of ZnO nanostructures using chemical bath deposition

    Energy Technology Data Exchange (ETDEWEB)

    Urgessa, Z.N., E-mail: [Department of Physics, P.O. Box 77000, Nelson Mandela Metropolitan University, Port Elizabeth 6031 (South Africa); Oluwafemi, O.S. [Department of Chemistry and Chemical Technology, Walter Sisulu University, Mthatha Campus, Private Bag XI, 5117 (South Africa); Botha, J.R. [Department of Physics, P.O. Box 77000, Nelson Mandela Metropolitan University, Port Elizabeth 6031 (South Africa)


    In this paper the growth process and morphological evolution of ZnO nanostructures were investigated in a series of experiments using chemical bath deposition. The experimental results indicate that the morphological evolution depends on the reaction conditions, particularly on OH{sup -} to Zn{sup 2+} ratio (which directly affects the pH). For low VI/II ratios, quasi-spherical nanoparticles of an average diameter 30 nm are obtained, whereas for larger VI/II ratios, nanorods with an average diameter less than 100 nm are produced, which indicates that by systematically controlling the VI/II ratio, it is possible to produce different shapes and sizes of ZnO nanostructures. A possible mechanism for the nanostructural change of the as-synthesized ZnO from particle to rod was elucidated based on the relative densities of H{sup +} and OH{sup -} in the solution.

  3. Role of VI/II ratio on the growth of ZnO nanostructures using chemical bath deposition

    International Nuclear Information System (INIS)

    Urgessa, Z.N.; Oluwafemi, O.S.; Botha, J.R.


    In this paper the growth process and morphological evolution of ZnO nanostructures were investigated in a series of experiments using chemical bath deposition. The experimental results indicate that the morphological evolution depends on the reaction conditions, particularly on OH − to Zn 2+ ratio (which directly affects the pH). For low VI/II ratios, quasi-spherical nanoparticles of an average diameter 30 nm are obtained, whereas for larger VI/II ratios, nanorods with an average diameter less than 100 nm are produced, which indicates that by systematically controlling the VI/II ratio, it is possible to produce different shapes and sizes of ZnO nanostructures. A possible mechanism for the nanostructural change of the as-synthesized ZnO from particle to rod was elucidated based on the relative densities of H + and OH − in the solution.

  4. EUCLID mission design (United States)

    Wallner, Oswald; Ergenzinger, Klaus; Tuttle, Sean; Vaillon, L.; Johann, Ulrich


    EUCLID, a medium-class mission candidate of ESA's Cosmic Vision 2015-2025 Program, currently in Definition Phase (Phase A/B1), shall map the geometry of the Dark Universe by investigating dark matter distributions, the distance-redshift relationship, and the evolution of cosmic structures. EUCLID consists of a 1.2 m telescope and two scientific instruments for ellipticity and redshift measurements in the visible and nearinfrared wavelength regime. We present a design concept of the EUCLID mission which is fully compliant with the mission requirements. Preliminary concepts of the spacecraft and of the payload including the scientific instruments are discussed.


    Directory of Open Access Journals (Sweden)

    Ichsan Luqmana Indra Putra


    Full Text Available Diversity of parasitic Hymenoptera in PTPN VIII oil palm plantation Cindali, Bogor. One group of important natural enemies in oil palm plantation is parasitic Hymenoptera. The purpose of this research is to know the diversity and fluctuation of parasitic Hymenoptera PTPN VIII Cindali oil palm plantation. This research was conducted in 6 blocks of oil palm in September 2014 – June 2015. There were 5 plots in every observation blocks 39.2 x 39.2 m in size, and used direct and indirect method. Direct method done by 5 plants in every plots was taken randomized to observed and taken the herbivore insects to reared until the parasitic Hymenoptera came out. Observation of cover crops conducted by 3 subplots determined diagonally in every plots 9.8 x 9.8 m in size and herbivore insects was observed and collected. Indirect methods used sweep net and yellow pan trap. The result of this research, 26 parasitic Hymenoptera families was found, with the Braconidae was the most morphospecies found and the most individual amount was Scelionidae. The abundance of parasitoid in every month fluctuated.

  6. Improving attitudes toward mathematics learning with problem posing in class VIII (United States)

    Vionita, Alfha; Purboningsih, Dyah


    This research is classroom action research which is collaborated to improve student's behavior toward math and mathematics learning at class VIII by using problem posing approach. The subject of research is all of students grade VIIIA which consist of 32 students. This research has been held on two period, first period is about 3 times meeting, and second period is about 4 times meeting. The instrument of this research is implementation of learning observation's guidance by using problem posing approach. Cycle test has been used to measure cognitive competence, and questionnaire to measure the students' behavior in mathematics learning process. The result of research shows the students' behavior has been improving after using problem posing approach. It is showed by the behavior's criteria of students that has increasing result from the average in first period to high in second period. Furthermore, the percentage of test result is also improve from 68,75% in first period to 78,13% in second period. On the other hand, the implementation of learning observation by using problem posing approach has also improving and it is showed by the average percentage of teacher's achievement in first period is 89,2% and student's achievement 85,8%. These results get increase in second period for both teacher and students' achievement which are 94,4% and 91,11%. As a result, students' behavior toward math learning process in class VIII has been improving by using problem posing approach.

  7. Innovative Approaches for Immune Tolerance to Factor VIII in the Treatment of Hemophilia A (United States)

    Sherman, Alexandra; Biswas, Moanaro; Herzog, Roland W.


    Hemophilia A (coagulation factor VIII deficiency) is a debilitating genetic disorder that is primarily treated with intravenous replacement therapy. Despite a variety of factor VIII protein formulations available, the risk of developing anti-dug antibodies (“inhibitors”) remains. Overall, 20–30% of patients with severe disease develop inhibitors. Current clinical immune tolerance induction protocols to eliminate inhibitors are not effective in all patients, and there are no prophylactic protocols to prevent the immune response. New experimental therapies, such as gene and cell therapies, show promising results in pre-clinical studies in animal models of hemophilia. Examples include hepatic gene transfer with viral vectors, genetically engineered regulatory T cells (Treg), in vivo Treg induction using immune modulatory drugs, and maternal antigen transfer. Furthermore, an oral tolerance protocol is being developed based on transgenic lettuce plants, which suppressed inhibitor formation in hemophilic mice and dogs. Hopefully, some of these innovative approaches will reduce the risk of and/or more effectively eliminate inhibitor formation in future treatment of hemophilia A. PMID:29225598


    Directory of Open Access Journals (Sweden)

    N. A. Shofiah


    Full Text Available Penelitian tindakan kelas yang bertujuan untuk meningkatkan kemampuan bersikap ilmiah, telah dilakukan di kelas VIII semester IIpada sub pokok bahasan pemantulan cahaya. Untuk meningkatkan kemampuan bersikap ilmiah diterapkan model pembelajaranbakulikan. Penelitian tindakan kelas ini terdiri dari tiga sikus, dengan masing-masing siklus terdiri dari empat tahapan yaituperencanaan, pelaksanaan, observasi dan refleksi. Data sikap ilmiah siswa diambil dari lembar angket dan lembar observasi. Datahasil belajar kognitif diambil dari evaluasi yang ada di LKS tiap akhir siklus dan data hasil belajar psikomotorik diambil dari lembarobservasi tiap akhir siklus. Hasil penelitian menyatakan bahwa sikap ilmiah siswa mengalami peningkatan walaupun tidaksignifikan. Hasil belajar kognitif dan keterampilan psikomotorik siswa mengalami peningkatan tiap siklus dan mencapai ketuntasanpada siklus III. A classroom action research aimed to improve scientific attitude skill had been done in second semester of grade VIII MTs on thesubtopic light reflection. The 'bakulikan' learning model was chosen for improving the scientific attitude skills of the students. Thisaction research consisted of three cycles, and each cycle has four stages, namely, planning, conducting, observation andreflection. The data obtained through questionnaire and observation sheets. The cognitive achievement drawn from the evaluationon each worksheet at the end of each cycle, and the psychometrics recorded from observation sheet. The study concludes that thescientific attitude skill improved significantly. The achievement on cognitive and psychometrics increase gradually on each cycleand get mastery at the end of the last cycle.Keywords: bakulikan; classroom action research; scientific attitude

  9. 46 CFR 54.01-2 - Adoption of division 1 of section VIII of the ASME Boiler and Pressure Vessel Code. (United States)


    ... Boiler and Pressure Vessel Code. 54.01-2 Section 54.01-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND... division 1 of section VIII of the ASME Boiler and Pressure Vessel Code. (a) Pressure vessels shall be designed, constructed, and inspected in accordance with section VIII of the ASME Boiler and Pressure Vessel...

  10. PLA Missions Beyond Taiwan

    National Research Council Canada - National Science Library

    Miller, Marc


    KEY INSIGHTS: *The PLA is being assigned and training for an increasing variety of missions, including nontraditional battlefields such as outer space and cyber space, as well as nontraditional functions...

  11. Human exploration mission studies (United States)

    Cataldo, Robert L.


    The Office of Exploration has established a process whereby all NASA field centers and other NASA Headquarters offices participate in the formulation and analysis of a wide range of mission strategies. These strategies were manifested into specific scenarios or candidate case studies. The case studies provided a systematic approach into analyzing each mission element. First, each case study must address several major themes and rationale including: national pride and international prestige, advancement of scientific knowledge, a catalyst for technology, economic benefits, space enterprise, international cooperation, and education and excellence. Second, the set of candidate case studies are formulated to encompass the technology requirement limits in the life sciences, launch capabilities, space transfer, automation, and robotics in space operations, power, and propulsion. The first set of reference case studies identify three major strategies: human expeditions, science outposts, and evolutionary expansion. During the past year, four case studies were examined to explore these strategies. The expeditionary missions include the Human Expedition to Phobos and Human Expedition to Mars case studies. The Lunar Observatory and Lunar Outpost to Early Mars Evolution case studies examined the later two strategies. This set of case studies established the framework to perform detailed mission analysis and system engineering to define a host of concepts and requirements for various space systems and advanced technologies. The details of each mission are described and, specifically, the results affecting the advanced technologies required to accomplish each mission scenario are presented.

  12. Missions to Venus (United States)

    Titov, D. V.; Baines, K. H.; Basilevsky, A. T.; Chassefiere, E.; Chin, G.; Crisp, D.; Esposito, L. W.; Lebreton, J.-P.; Lellouch, E.; Moroz, V. I.; Nagy, A. F.; Owen, T. C.; Oyama, K.-I.; Russell, C. T.; Taylor, F. W.; Young, R. E.


    Venus has always been a fascinating objective for planetary studies. At the beginning of the space era Venus became one of the first targets for spacecraft missions. Our neighbour in the solar system and, in size, the twin sister of Earth, Venus was expected to be very similar to our planet. However, the first phase of Venus spacecraft exploration in 1962-1992 by the family of Soviet Venera and Vega spacecraft and US Mariner, Pioneer Venus, and Magellan missions discovered an entirely different, exotic world hidden behind a curtain of dense clouds. These studies gave us a basic knowledge of the conditions on the planet, but generated many more questions concerning the atmospheric composition, chemistry, structure, dynamics, surface-atmosphere interactions, atmospheric and geological evolution, and the plasma environment. Despite all of this exploration by more than 20 spacecraft, the "morning star" still remains a mysterious world. But for more than a decade Venus has been a "forgotten" planet with no new missions featuring in the plans of the world space agencies. Now we are witnessing the revival of interest in this planet: the Venus Orbiter mission is approved in Japan, Venus Express - a European orbiter mission - has successfully passed the selection procedure in ESA, and several Venus Discovery proposals are knocking at the doors of NASA. The paper presents an exciting story of Venus spacecraft exploration, summarizes open scientific problems, and builds a bridge to the future missions.

  13. Purification and characterization of factor VIII 1,689-Cys: a nonfunctional cofactor occurring in a patient with severe hemophilia A. (United States)

    O'Brien, D P; Tuddenham, E G


    We have purified the factor VIII from a CRM+ Hemophilia A plasma (90 U/dL VIII:Ag but 0 U/dL VIII:C) and analyzed the protein before and after thrombin activation by Western blotting with monoclonal antibodies (MoAbs). Normal or patient citrated plasma was ultracentrifuged, cryo-ethanol-precipitated and chromatographed on Sepharose 6B. The void volume fractions were reduced and subjected to ion exchange chromatography yielding material of specific activity approximately 1,000 U/mg protein (VIII:C or VIII:Ag). Factor VIII purified in this way from normal plasma is fully activatable by thrombin with proteolytic fragmentation as previously described by F. Rotblat et al (Biochemistry 24: 4294, 1985). Factor VIII 1,689-Cys has the normal distribution of factor VIII light and heavy chains prior to thrombin activation. After exposure to thrombin the heavy chain polypeptides were fully proteolysed but the light chain was totally resistant to cleavage. This is consistent with the demonstration in the patient's leucocyte DNA of a C to T transition in codon 1,689 converting Arg to Cys at the light chain thrombin cleavage site as previously described by J. Gitschier et al (Blood 72:1022, 1988). Uncleaved light chain of Factor VIII 1,689-Cys is not released from von Willebrand factor (vWF) by thrombin, but this is not the sole cause of the functional defect since the protein purified free of vWF has no coagulant activity. We conclude that the functional defect in factor VIII 1,689-Cys is a consequence of failure to release the acidic peptide from the light chain upon thrombin activation.

  14. Analysis of factor VIII gene inversions in 164 unrelated hemophilia A families

    Energy Technology Data Exchange (ETDEWEB)

    Vnencak-Jones, L.; Phillips, J.A. III; Janco, R.L. [Vanderbilt Univ. School of Medicine, Nashville, TN (United States)] [and others


    Hemophilia A is an X-linked recessive disease with variable phenotype and both heterogeneous and wide spread mutations in the factor VIII (F8) gene. As a result, diagnostic carrier or prenatal testing often relies upon laborious DNA linkage analysis. Recently, inversion mutations resulting from an intrachromosomal recombination between DNA sequences in one of two A genes {approximately}500 kb upstream from the F8 gene and a homologous A gene in intron 22 of the F8 gene were identified and found in 45% of severe hemophiliacs. We have analyzed banked DNA collected since 1986 from affected males or obligate carrier females representing 164 unrelated hemophilia A families. The disease was sporadic in 37%, familial in 54% and in 10% of families incomplete information was given. A unique deletion was identified in 1/164, a normal pattern was observed in 110/164 (67%), and 53/164 (32%) families had inversion mutations with 43/53 (81%) involving the distal A gene (R3 pattern) and 10/53 (19%) involving the proximal A gene (R2 pattern). While 19% of all rearrangements were R2, in 35 families with severe disease (< 1% VIII:C activity) all 16 rearrangements seen were R3. In 18 families with the R3 pattern and known activities, 16 (89%) had levels < 1%, with the remaining 2 families having {le} 2.4% activity. Further, 18 referrals specifically noted the production of inhibitors and 8/18 (45%) had the R3 pattern. Our findings demonstrate that the R3 inversion mutation patterns is (1) only seen with VIII:C activity levels of {le} 2.4%, (2) seen in 46% of families with severe hemophilia, (3) seen in 45% of hemophiliacs known to have inhibitors, (4) not correlated with sporadic or familial disease and (5) not in disequilibrium with the Bcl I or Taq I intron 18 or ST14 polymorphisms. Finally, in families positive for an inversion mutation, direct testing offers a highly accurate and less expensive alternative to DNA linkage analysis.

  15. Keefektifan Experiential Learning Berbantuan Origami Terhadap Kemampuan Keruangan Siswa Kelas VIII

    Directory of Open Access Journals (Sweden)

    Isnaeni Umi Machromah


    Full Text Available AbstrakPenelitian eksperimen ini bertujuan untuk mengetahui keefektifan pembelajaran Experiential Learning berbantuan origami terhadap kemampuan keruangan siswa dengan kualifikasi keefektifan yang telah ditentukan. Populasi yaitu siswa kelas VIII SMP Negeri 3 Colomadu tahun pelajaran 2012/2013. Sampel diambil secara simple random sampling. Hasil penelitian ini yaitu: (1 Uji proporsi ketuntasan belajar menunjukkan siswa kelompok eksperimen telah mencapai ketuntasan belajar; (2 Uji perbedaan dua rata-rata menghasilkan simpulan bahwa rata-rata hasil post-test kemam-puan keruangan siswa kelompok eksperimen lebih dari kelompok kontrol; (3 Analisis re-gresi menunjukkan bahwa motivasi belajar siswa memberikan pengaruh positif sebesar 49,3% terhadap kemampuan keruangan siswa; (4 Uji gain ternormalisasi menunjukkan terdapat peningkatan kemampuan keruangan siswa secara signifikan pada kategaori sedang untuk kelompok eksperimen dan kategori rendah untuk kelompok kontrol. Simpulan yang diperoleh yaitu Experiential Learning berbantuan origami efektif terhadap kemampuan keruangan siswa kelas VIII. AbstractThis experiment research aims to determine the effectiveness of Experiential Learning with Origami to the students’s spatial abilities by the criteria of effectiveness. The population of this research is students of grade VIII of SMP Negeri 3 Colomadu 2012/2013 academic year. Independent variables used in this research are learning by Experiential Learning with origami and student’s motivation. While the dependent variable is the student’s spatial abilities. This research is using documentation, spatial abilities’s test, dan motivation’s scale for collecting data method. Result of this research are: (1 proportion test show that the experiment group has reached mastering of learning clasically and personally; (2 result of spatial ablities’s post test in experiment group better than control group; (3 result of regretion shows that student

  16. Mission operations technology (United States)

    Varsi, Giulio

    In the last decade, the operation of a spacecraft after launch has emerged as a major component of the total cost of the mission. This trend is sustained by the increasing complexity, flexibility, and data gathering capability of the space assets and by their greater reliability and consequent longevity. The trend can, however, be moderated by the progressive transfer of selected functions from the ground to the spacecraft and by application, on the ground, of new technology. Advances in ground operations derive from the introduction in the mission operations environment of advanced microprocessor-based workstations in the class of a few million instructions per second and from the selective application of artificial intelligence technology. In the last few years a number of these applications have been developed, tested in operational settings and successfully demonstrated to users. Some are now being integrated in mission operations facilities. An analysis of mission operations indicates that the key areas are: concurrent control of multiple missions; automated/interactive production of command sequences of high integrity at low cost; automated monitoring of spacecraft health and automated aides for fault diagnosis; automated allocation of resources; automated processing of science data; and high-fidelity, high-speed spacecraft simulation. Examples of major advances in selected areas are described.

  17. Factor VIII S373L: mutation at P1' site confers thrombin cleavage resistance, causing mild haemophilia A. (United States)

    Johnson, D J; Pemberton, S; Acquila, M; Mori, P G; Tuddenham, E G; O'Brien, D P


    A novel CRM+ mutation, factor VIII position 373 serine to leucine substitution (FVIII 373-Leu) was identified during a survey of Factor VIII (FVIII) mutations. We have purified the variant protein from the patient's plasma in order to allow further characterisation of the molecule. The CRM+ plasma contained 120% Factor VIII antigen (FVIII:Ag) and 6% Factor VIII coagulant activity (FVIII:C). After purification the mutant FVIII was subjected to thrombin proteolysis, and was thereby activated 5.6-fold compared with 7-fold for wild type molecule. Subsequently, spontaneous inactivation of the mutant was much slower than noted for wild type FVIII. Western blot analysis using monoclonal antibodies demonstrated that thrombin cleavage of FVIII 373-Leu at positions 740 and 1689 were normal but that cleavage at position 372 was completely absent. Crystallographic coordinates of the active site of thrombin complexed to fibrinopeptide A were used to explore possible mechanistic reasons for the failure of thrombin to cleave the mutant FVIII at position 372. Steric hindrance between the mutant side chain and the side chain of the P1 residue was apparent. We conclude that the functional defect of FVIII 373-Leu results from the inability of thrombin to cleave the mutant at position 372-373, and propose that this is due to steric hindrance by the side chain of leucine 373, preventing correct formation of the enzyme substrate complex.

  18. The new albumin-free recombinant factor VIII concentrates for treatment of hemophilia: do they represent an actual incremental improvement? (United States)

    Josephson, Cassandra D; Abshire, Thomas


    The goal of eliminating the low levels of infectious disease risk from hemophilia treatment has resulted in the development of multiple generations of recombinant factor VIII (rFVIII) products. The ideal product should be devoid of human and animal proteins, which may transmit infectious agents. These products should also maintain molecular integrity, hemostatic efficacy, similar immunogenicity, and acceptable side effect profiles as compared to plasma-derived factor VIII. Currently available first-, second-, and third-generation rFVIII products include Recombinate; Kogenate FS/Helixate FS and ReFacto; and Advate, respectively. During the evolution of rFVIII products, either full-length or B-domain-deleted factor VIII were transfected into immortalized cell lines. The B-domain-deleted product, ReFacto, has resulted in an additional method to monitor factor VIII levels. The third-generation products offer the theoretical advantage of being produced without human and/or animal proteins. Upon initial introduction into the marketplace, the newer products have a higher cost. However, when analyzing historical trends, the prices of these products are almost equivalent to first-generation products within 3 years of licensure. Thus, the initial cost of the product may be a minimal issue in the medical decision process when selecting rFVIII replacement therapy.

  19. Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A

    NARCIS (Netherlands)

    Collins, P. W.; Blanchette, V. S.; Fischer, K.; Bjorkman, S.; Oh, M.; Fritsch, S.; Schroth, P.; Spotts, G.; Astermark, J.; Ewenstein, B.

    Background: The role of prophylactic factor VIII (FVIII) to decrease hemophilic bleeding and arthropathy is well established. The rationale for this strategy is to convert patients with severe hemophilia A to a moderate clinical phenotype by reducing time spent with a FVIII level <1 IU dL(-1).

  20. Tranexamic acid combined with recombinant factor VIII increases clot resistance to accelerated fibrinolysis in severe hemophilia A

    DEFF Research Database (Denmark)

    Hvas, Anne-Mette; Sørensen, Hanne Thykjær; Norengaard, Lisbeth


    examined whether the clot stability in hemophiliacs could be improved by treatment with tranexamic acid (TXA) in combination with recombinant factor VIII (rFVIII). PATIENTS/METHODS: Baseline blood samples were obtained from eight males with severe hemophilia A. Thereafter, a bolus injection of r...

  1. 75 FR 36426 - Legislative Changes to Nursing Student Loan Program Authorized Under Title VIII of the Public... (United States)


    ... Changes to Nursing Student Loan Program Authorized Under Title VIII of the Public Health Service Act....) 111-148. Section 5202 of the ACA changes the Nursing Student Loan (NSL) program by: (1) Increasing the... degree in nursing. Below are details on how the ACA changes Sections 836(a), 836(b)(1), and 836(b)(3) of...

  2. Chromosome VIII disomy influences the nonsense suppression efficiency and transition metal tolerance of the yeast Saccharomyces cerevisiae. (United States)

    Zadorsky, S P; Sopova, Y V; Andreichuk, D Y; Startsev, V A; Medvedeva, V P; Inge-Vechtomov, S G


    The SUP35 gene of the yeast Saccharomyces cerevisiae encodes the translation termination factor eRF3. Mutations in this gene lead to the suppression of nonsense mutations and a number of other pleiotropic phenotypes, one of which is impaired chromosome segregation during cell division. Similar effects result from replacing the S. cerevisiae SUP35 gene with its orthologues. A number of genetic and epigenetic changes that occur in the sup35 background result in partial compensation for this suppressor effect. In this study we showed that in S. cerevisiae strains in which the SUP35 orthologue from the yeast Pichia methanolica replaces the S. cerevisiae SUP35 gene, chromosome VIII disomy results in decreased efficiency of nonsense suppression. This antisuppressor effect is not associated with decreased stop codon read-through. We identified SBP1, a gene that localizes to chromosome VIII, as a dosage-dependent antisuppressor that strongly contributes to the overall antisuppressor effect of chromosome VIII disomy. Disomy of chromosome VIII also leads to a change in the yeast strains' tolerance of a number of transition metal salts. Copyright © 2015 John Wiley & Sons, Ltd.

  3. Evaluation of the biological differences of canine and human factor VIII in gene delivery: Implications in human hemophilia treatment (United States)

    The canine is the most important large animal model for testing novel hemophilia A(HA) treatment. It is often necessary to use canine factor VIII (cFIII) gene or protein for the evaluation of HA treatment in the canine model. However, the different biological properties between cFVIII and human FVII...

  4. Mission to the comets

    International Nuclear Information System (INIS)

    Hughes, D.


    The plans of space agencies in the United States and Europe for an exploratory comet mission including a one year rendezvous with comet Temple-2 and a fast fly-by of comet Halley are discussed. The mission provides an opportunity to make comparative measurements on the two different types of comets and also satisfies the three major scientific objectives of cometary missions namely: (1) To determine the chemical nature and the physical structure of cometary nuclei, and the changes that occur with time and orbital position. (2) To study the chemical and physical nature of the atmospheres and ionospheres of comets, the processes that occur in them, and their development with time and orbital position. (3) To determine the nature of the tails of comets and the processes by which they are formed, and to characterise the interaction of comets with solar wind. (UK)

  5. Country programming mission. Namibia

    International Nuclear Information System (INIS)


    In response to a request from the Government of Namibia conveyed in a letter dated 29 November 1990 IAEA provided a multi-disciplinary Programming Mission which visited Namibia from 15 - 19 July 1991. The terms of reference of the Mission were: 1. To assess the possibilities and benefits of nuclear energy applications in Namibia's development; 2. To advise on the infrastructure required for nuclear energy projects; 3. To assist in the formulation of project proposals which could be submitted for Agency assistance. This report is based on the findings of the Mission and falls into 3 sections with 8 appendices. The first section is a country profile providing background information, the second section deals with sectorial needs and institutional review of the sectors of agriculture including animal production, life sciences (nuclear medicine and radiotherapy) and radiation protection. The third section includes possible future technical co-operation activities

  6. Evaluation of Neutron Reactions on Iron Isotopes for CIELO and ENDF/B-VIII.0 (United States)

    Herman, M.; Trkov, A.; Capote, R.; Nobre, G. P. A.; Brown, D. A.; Arcilla, R.; Danon, Y.; Plompen, A.; Mughabghab, S. F.; Jing, Q.; Zhigang, G.; Tingjin, L.; Hanlin, L.; Xichao, R.; Leal, L.; Carlson, B. V.; Kawano, T.; Sin, M.; Simakov, S. P.; Guber, K.


    A new suite of evaluations for 54,56,57,58Fe has been developed in the framework of the CIELO international collaboration. New resolved resonance ranges were evaluated for 54Fe and 57Fe, while modifications were applied to resonances in 56Fe. The low energy part of the 56Fe file is almost totally based on measurements. At higher energies in 56Fe and in the whole fast neutron range for minor isotopes the evaluation consists of model predictions carefully adjusted to available experimental data. We also make use of the high quality and well experimentally-constrained dosimetry evaluations from the IRDFF library. Special attention was dedicated to the elastic angular distributions, which were found to affect results of the integral benchmarking. The new set of iron evaluations was developed in concert with other CIELO evaluations and they were tested together in the integral experiments before being adopted for the ENDF/B-VIII.0 library.


    Directory of Open Access Journals (Sweden)

    Ummi Farikhatun Nisa


    Full Text Available The purpose of this research was to determine the efforts and success in improving students' social responsibility through group counseling services. Type of research used action research. Subjects were 12 students who had low social responsibility and being. Data collection technique used were psychological scales and observation. Data analysis techniques used are non-parametric statistics with the Wilcoxon test. Based on the calculations for the Wilcoxon test, a small amount of levels or Z value was 78.0. While Ztabel for n = 12 with an error level of 5% value is 14. So Z 78.0> 14.0 Ztabel or imply hypothesis accepted. These results demonstrate social responsibility of students prior to obtaining counseling services group at 51.93% (low. After following the guidance services at 81.51% (high. Conclusions from this research is a social responsibility to the students of class VIII SMP Putra Bangsa Bantarkawung increase after getting tutoring services group.

  8. X-ray spectral line coincidences between fluorine VIII (and IX) and transition metal lines

    International Nuclear Information System (INIS)

    Charatis, G.; Rockett, P.D.; Burkhalter, P.G.


    X-ray spectroscopy was performed in the 12 to 15 A region, recording L-shell lines from selected laser-irradiated transition metals. Line coincidences and near coincidences were identified between Fe, Cr, Mn, and Ni L-spectra, and F VIII and F IX K-shell lines. Wavelengths were determined to accuracies of 1 to 3 mA and will be utilized in selecting potential pumping candidates in future x-ray lasing schemes. High-resolution x-ray spectra were collected under controlled illumination and target conditions using 1.05 μm and 0.527 μm laser excitation with the KMS CHROMA laser

  9. Symposium by NATO Defense Research Group Panel VIII on Computer-Based Instruction in Military Environments

    CERN Document Server

    Weddle, Peter


    This collection of papers is the result of a symposium sponsored by NATO's Defense Research Group Panel VIII in the Spring of 1985. The symposium came into being when it became obvious to the NATO countries that research, development and utilization of advanced technologies for training was the best means of increasing both training effectiveness and efficiency. This symposium was the second in a series of three devoted to training. The series was structured to cover all aspects of training. The first series addressed the value of training, the second one dealt with the application of training technologies and the third and last of the series focused on academic issues concerned with the effect of prior learning on subsequent learning. The fact that a major American publisher has determined that computer based instruction is the technology of greatest interest to the NATO community is not surprising. Advances in microprocessor technology have revolutionized both how and where we train. During this symposium t...


    Directory of Open Access Journals (Sweden)

    Haeruddin Niva


    Full Text Available The objectives of the research are: (i to know the prosocial behavioral level of the students in Bosowa International School Makassar before and after giving cinematography approach, and (ii to know whether or not the approach is able to enhance the prosocial behavior of the students in Bosowa International School Makassar. The research is a quantitative research using experimental method. The research design used is quasi experimental design with non-equivalent control group design. The data collection technique applied is scale and FGD (Focus Group Discussion. The findings shows that (i the prosocial behavioral level of the students was low in pretest while after giving treatment there were significant increase to the prosocial behavior in the experimental group, and (ii the cinematography approach was able to increase the prosocial behavior of the Grade VIII students in Bosowa Internatinal School Makassar. 

  11. Assessing patients' and caregivers' perspectives on stability of factor VIII products for haemophilia A

    DEFF Research Database (Denmark)

    DiBenedetti, D B; Coles, T M; Sharma, T


    Haemophilia A is a rare inherited bleeding disorder characterized by an inability of the blood to clot normally. Patients can experience spontaneous or trauma-induced joint and soft tissue bleeding and must keep coagulation factor VIII (FVIII) accessible at all times; thus, FVIII product storage...... challenges with storing FVIII products, especially storage away from home. More than half preferred storing FVIII products at room temperature vs. in the refrigerator for long periods of time. FVIII product accessibility, usage and storage affect disease management. Results support the need for more...... convenient and accessible FVIII products for patients in daily life and while travelling. In addition, the use of social media has potential value in recruiting this population....

  12. The transitions 4p-5s in Y VI, Zr VII, Nb VIII and Mo IX

    International Nuclear Information System (INIS)

    Chaghtai, M.S.Z.; Rahimullah, K.; Khatoon, S.


    With the help of the spectra recorded in the Physics Department of Lund University, Y VI, Zr VII, Nb VIII and Mo IX are freshly analysed. The five 4s 2 4p 4 ground levels and the ten 4s 2 4p 3 5s levels of previous analyses are confirmed in the first three spectra, except for revising in Y VI the 4p 4 1 S 0 and 4p 3 5s( 4 Ssub(3/2)) 2 levels and interchanging 5s( 2 Dsub(3/2)) 1 with 5s( 2 Dsub(3/2)) 2 . All level values are improved due to the new measurements. A new analysis of Mo IX establishing all the 4p 4 and 4p 3 5s levels is being reported. (Auth.)

  13. MIV Project: Mission scenario

    DEFF Research Database (Denmark)

    Ravazzotti, Mariolina T.; Jørgensen, John Leif; Thuesen, Gøsta


    Under the ESA contract #11453/95/NL/JG(SC), aiming at assessing the feasibility of Rendez-vous and docking of unmanned spacecrafts, a msiision scenario was defined. This report describes the secquence of manouvres and task allocations for such missions.......Under the ESA contract #11453/95/NL/JG(SC), aiming at assessing the feasibility of Rendez-vous and docking of unmanned spacecrafts, a msiision scenario was defined. This report describes the secquence of manouvres and task allocations for such missions....

  14. Mars Stratigraphy Mission (United States)

    Budney, C. J.; Miller, S. L.; Cutts, J. A.


    The Mars Stratigraphy Mission lands a rover on the surface of Mars which descends down a cliff in Valles Marineris to study the stratigraphy. The rover carries a unique complement of instruments to analyze and age-date materials encountered during descent past 2 km of strata. The science objective for the Mars Stratigraphy Mission is to identify the geologic history of the layered deposits in the Valles Marineris region of Mars. This includes constraining the time interval for formation of these deposits by measuring the ages of various layers and determining the origin of the deposits (volcanic or sedimentary) by measuring their composition and imaging their morphology.

  15. The OICETS mission (United States)

    Jono, Takashi; Arai, Katsuyoshi


    The Optical Inter-orbit Communications Engineering Test Satellite (OICETS) was successfully launched on 23th August 2005 and thrown into a circular orbit at the altitude of 610 km. The main mission is to demonstrate the free-space inter satellite laser communications with the cooperation of the Advanced Relay and Technology Mission (ARTEMIS) geostationary satellite developed by the European Space Agency. This paper presents the overview of the OICETS and laser terminal, a history of international cooperation between Japan Aerospace Exploration Agency (JAXA) and ESA and typical results of the inter-orbit laser communication experiment carried out with ARTEMIS.

  16. Factor VIII brand and the incidence of factor VIII inhibitors in previously untreated UK children with severe hemophilia A, 2000-2011 (United States)

    Palmer, Benedict P.; Chalmers, Elizabeth A.; Hart, Daniel P.; Liesner, Ri; Rangarajan, Savita; Talks, Katherine; Williams, Michael; Hay, Charles R. M.


    The effect of recombinant factor VIII (rFVIII) brand on inhibitor development was investigated in all 407 severe hemophilia A previously untreated patients born in the United Kingdom (UK) between 1 January 2000 and 31 December 2011. Eighty-eight (22%) had been in the RODIN study. Information was extracted from the National Haemophilia Database. Because exposure days (EDs) were not known for some patients, time from first treatment was used as a surrogate for rFVIII exposure. An inhibitor developed in 118 (29%) patients, 60 high and 58 low titer, after a median (interquartile range) of 7.8 (3.3-13.5) months from first exposure and 16 (9-30) EDs. Of 128 patients treated with Kogenate Bayer/Helixate NexGen, 45 (35.2%, 95% confidence interval [CI] 27.4-43.8) developed an inhibitor compared with 42/172 (24.4%, 95% CI 18.6% to 31.4%) with Advate (P = .04). The adjusted hazard ratio (HR) (95% CI) for Kogenate Bayer/Helixate NexGen compared with Advate was 2.14 (1.12-4.10) (P = .02) for high titer and 1.75 (1.11-2.76) (P = .02) for all inhibitors. When excluding UK-RODIN patients, the adjusted HR (95% CI) for high-titer inhibitors was 2.00 (0.93-4.34) (P = .08). ReFacto AF was associated with a higher incidence of all, but not high-titer, inhibitors than Advate. These results will help inform debate around the relative immunogenicity and use of rFVIII brands. PMID:25339360

  17. Robust UAV Mission Planning

    NARCIS (Netherlands)

    Evers, L.; Dollevoet, T.; Barros, A.I.; Monsuur, H.


    Unmanned Aerial Vehicles (UAVs) can provide significant contributions to information gathering in military missions. UAVs can be used to capture both full motion video and still imagery of specific target locations within the area of interest. In order to improve the effectiveness of a

  18. Robust UAV mission planning

    NARCIS (Netherlands)

    Evers, L.; Dollevoet, T.; Barros, A.I.; Monsuur, H.


    Unmanned Areal Vehicles (UAVs) can provide significant contributions to information gathering in military missions. UAVs can be used to capture both full motion video and still imagery of specific target locations within the area of interest. In order to improve the effectiveness of a reconnaissance

  19. Robust UAV Mission Planning

    NARCIS (Netherlands)

    Evers, L.; Dollevoet, T; Barros, A.I.; Monsuur, H.


    Unmanned Aerial Vehicles (UAVs) can provide significant contributions to information gathering in military missions. UAVs can be used to capture both full motion video and still imagery of specific target locations within the area of interest. In order to improve the effectiveness of a

  20. Robust UAV Mission Planning

    NARCIS (Netherlands)

    L. Evers (Lanah); T.A.B. Dollevoet (Twan); A.I. Barros (Ana); H. Monsuur (Herman)


    textabstractUnmanned Areal Vehicles (UAVs) can provide significant contributions to information gathering in military missions. UAVs can be used to capture both full motion video and still imagery of specific target locations within the area of interest. In order to improve the effectiveness of a

  1. The Lobster Mission (United States)

    Barthelmy, Scott


    I will give an overview of the Goddard Lobster mission: the science goals, the two instruments, the overall instruments designs, with particular attention to the wide-field x-ray instrument (WFI) using the lobster-eye-like micro-channel optics.

  2. Towards A Shared Mission

    DEFF Research Database (Denmark)

    Staunstrup, Jørgen; Orth Gaarn-Larsen, Carsten

    A mission shared by stakeholders, management and employees is a prerequisite for an engaging dialog about the many and substantial changes and challenges currently facing universities. Too often this essen-tial dialog reveals mistrust and misunderstandings about the role and outcome of the univer......A mission shared by stakeholders, management and employees is a prerequisite for an engaging dialog about the many and substantial changes and challenges currently facing universities. Too often this essen-tial dialog reveals mistrust and misunderstandings about the role and outcome...... on a shared mission aiming at value creation (in the broadest interpretation). One important aspect of choosing value as the cornerstone of the mission of universities is to stress that the outcome is measured by external stakeholders and by their standards. Most of the paper is devoted to discussing value...... it possible to lead through processes that engage and excite while creating transparency and accountability. The paper will be illustrated with examples from Denmark and the Helios initiative taken by the Danish Academy of Technical Sciences (ATV) under the headline “The value creating university – courage...

  3. Titan Orbiter Aerorover Mission (United States)

    Sittler Jr., E. C.; Acuna, M.; Burchell, M. J.; Coates, A.; Farrell, W.; Flasar, M.; Goldstein, B. E.; Gorevan, S.; Hartle, R. E.; Johnson, W. T. K.


    We propose a combined Titan orbiter and Titan Aerorover mission with an emphasis on both in situ and remote sensing measurements of Titan's surface, atmosphere, ionosphere, and magnetospheric interaction. The biological aspect of the Titan environment will be emphasized by the mission (i.e., search for organic materials which may include simple organics to 'amono' analogues of amino acids and possibly more complex, lightening detection and infrared, ultraviolet, and charged particle interactions with Titan's surface and atmosphere). An international mission is assumed to control costs. NASA will provide the orbiter, launch vehicle, DSN coverage and operations, while international partners will provide the Aerorover and up to 30% of the cost for the scientific instruments through collaborative efforts. To further reduce costs we propose a single PI for orbiter science instruments and a single PI for Aerorover science instruments. This approach will provide single command/data and power interface between spacecraft and orbiter instruments that will have redundant central DPU and power converter for their instruments. A similar approach could be used for the Aerorover. The mission profile will be constructed to minimize conflicts between Aerorover science, orbiter radar science, orbiter radio science, orbiter imaging science, and orbiter fields and particles (FP) science. Additional information is contained in the original extended abstract.

  4. The LISA Pathfinder Mission

    International Nuclear Information System (INIS)

    Armano, M; Audley, H; Born, M; Danzmann, K; Diepholz, I; Auger, G; Binetruy, P; Baird, J; Bortoluzzi, D; Brandt, N; Fitzsimons, E; Bursi, A; Caleno, M; Cavalleri, A; Cesarini, A; Dolesi, R; Ferroni, V; Cruise, M; Dunbar, N; Ferraioli, L


    LISA Pathfinder (LPF), the second of the European Space Agency's Small Missions for Advanced Research in Technology (SMART), is a dedicated technology validation mission for future spaceborne gravitational wave detectors, such as the proposed eLISA mission. LISA Pathfinder, and its scientific payload - the LISA Technology Package - will test, in flight, the critical technologies required for low frequency gravitational wave detection: it will put two test masses in a near-perfect gravitational free-fall and control and measure their motion with unprecedented accuracy. This is achieved through technology comprising inertial sensors, high precision laser metrology, drag-free control and an ultra-precise micro-Newton propulsion system. LISA Pathfinder is due to be launched in mid-2015, with first results on the performance of the system being available 6 months thereafter.The paper introduces the LISA Pathfinder mission, followed by an explanation of the physical principles of measurement concept and associated hardware. We then provide a detailed discussion of the LISA Technology Package, including both the inertial sensor and interferometric readout. As we approach the launch of the LISA Pathfinder, the focus of the development is shifting towards the science operations and data analysis - this is described in the final section of the paper (paper)

  5. The Gaia mission

    NARCIS (Netherlands)

    Collaboration, Gaia; Prusti, T.; de Bruijne, J. H. J.; Brown, A. G. A.; Vallenari, A.; Babusiaux, C.; Bailer-Jones, C. A. L.; Bastian, U.; Biermann, M.; Evans, D. W.; Eyer, L.; Jansen, F.; Jordi, C.; Klioner, S. A.; Lammers, U.; Lindegren, L.; Luri, X.; Mignard, F.; Milligan, D. J.; Panem, C.; Poinsignon, V.; Pourbaix, D.; Randich, S.; Sarri, G.; Sartoretti, P.; Siddiqui, H. I.; Soubiran, C.; Valette, V.; van Leeuwen, F.; Walton, N. A.; Aerts, C.; Arenou, F.; Cropper, M.; Drimmel, R.; Høg, E.; Katz, D.; Lattanzi, M. G.; O'Mullane, W.; Grebel, E. K.; Holland, A. D.; Huc, C.; Passot, X.; Bramante, L.; Cacciari, C.; Castañeda, J.; Chaoul, L.; Cheek, N.; De Angeli, F.; Fabricius, C.; Guerra, R.; Hernández, J.; Jean-Antoine-Piccolo, A.; Masana, E.; Messineo, R.; Mowlavi, N.; Nienartowicz, K.; Ordóñez-Blanco, D.; Panuzzo, P.; Portell, J.; Richards, P. J.; Riello, M.; Seabroke, G. M.; Tanga, P.; Thévenin, F.; Torra, J.; Els, S. G.; Gracia-Abril, G.; Comoretto, G.; Garcia-Reinaldos, M.; Lock, T.; Mercier, E.; Altmann, M.; Andrae, R.; Astraatmadja, T. L.; Bellas-Velidis, I.; Benson, K.; Berthier, J.; Blomme, R.; Busso, G.; Carry, B.; Cellino, A.; Clementini, G.; Cowell, S.; Creevey, O.; Cuypers, J.; Davidson, M.; De Ridder, J.; de Torres, A.; Delchambre, L.; Dell'Oro, A.; Ducourant, C.; Frémat, Y.; García-Torres, M.; Gosset, E.; Halbwachs, J. -L; Hambly, N. C.; Harrison, D. L.; Hauser, M.; Hestroffer, D.; Hodgkin, S. T.; Huckle, H. E.; Hutton, A.; Jasniewicz, G.; Jordan, S.; Kontizas, M.; Korn, A. J.; Lanzafame, A. C.; Manteiga, M.; Moitinho, A.; Muinonen, K.; Osinde, J.; Pancino, E.; Pauwels, T.; Petit, J. -M; Recio-Blanco, A.; Robin, A. C.; Sarro, L. M.; Siopis, C.; Smith, M.; Smith, K. W.; Sozzetti, A.; Thuillot, W.; van Reeven, W.; Viala, Y.; Abbas, U.; Abreu Aramburu, A.; Accart, S.; Aguado, J. J.; Allan, P. M.; Allasia, W.; Altavilla, G.; Álvarez, M. A.; Alves, J.; Anderson, R. I.; Andrei, A. H.; Anglada Varela, E.; Antiche, E.; Antoja, T.; Antón, S.; Arcay, B.; Atzei, A.; Ayache, L.; Bach, N.; Baker, S. G.; Balaguer-Núñez, L.; Barache, C.; Barata, C.; Barbier, A.; Barblan, F.; Baroni, M.; Barrado y Navascués, D.; Barros, M.; Barstow, M. A.; Becciani, U.; Bellazzini, M.; Bellei, G.; Bello García, A.; Belokurov, V.; Bendjoya, P.; Berihuete, A.; Bianchi, L.; Bienaymé, O.; Billebaud, F.; Blagorodnova, N.; Blanco-Cuaresma, S.; Boch, T.; Bombrun, A.; Borrachero, R.; Bouquillon, S.; Bourda, G.; Bouy, H.; Bragaglia, A.; Breddels, M. A.; Brouillet, N.; Brüsemeister, T.; Bucciarelli, B.; Budnik, F.; Burgess, P.; Burgon, R.; Burlacu, A.; Busonero, D.; Buzzi, R.; Caffau, E.; Cambras, J.; Campbell, H.; Cancelliere, R.; Cantat-Gaudin, T.; Carlucci, T.; Carrasco, J. M.; Castellani, M.; Charlot, P.; Charnas, J.; Charvet, P.; Chassat, F.; Chiavassa, A.; Clotet, M.; Cocozza, G.; Collins, R. S.; Collins, P.; Costigan, G.; Crifo, F.; Cross, N. J. G.; Crosta, M.; Crowley, C.; Dafonte, C.; Damerdji, Y.; Dapergolas, A.; David, P.; David, M.; De Cat, P.; de Felice, F.; de Laverny, P.; De Luise, F.; De March, R.; de Martino, D.; de Souza, R.; Debosscher, J.; del Pozo, E.; Delbo, M.; Delgado, A.; Delgado, H. E.; di Marco, F.; Di Matteo, P.; Diakite, S.; Distefano, E.; Dolding, C.; Dos Anjos, S.; Drazinos, P.; Durán, J.; Dzigan, Y.; Ecale, E.; Edvardsson, B.; Enke, H.; Erdmann, M.; Escolar, D.; Espina, M.; Evans, N. W.; Eynard Bontemps, G.; Fabre, C.; Fabrizio, M.; Faigler, S.; Falcão, A. J.; Farràs Casas, M.; Faye, F.; Federici, L.; Fedorets, G.; Fernández-Hernández, J.; Fernique, P.; Fienga, A.; Figueras, F.; Filippi, F.; Findeisen, K.; Fonti, A.; Fouesneau, M.; Fraile, E.; Fraser, M.; Fuchs, J.; Furnell, R.; Gai, M.; Galleti, S.; Galluccio, L.; Garabato, D.; García-Sedano, F.; Garé, P.; Garofalo, A.; Garralda, N.; Gavras, P.; Gerssen, J.; Geyer, R.; Gilmore, G.; Girona, S.; Giuffrida, G.; Gomes, M.; González-Marcos, A.; González-Núñez, J.; González-Vidal, J. J.; Granvik, M.; Guerrier, A.; Guillout, P.; Guiraud, J.; Gúrpide, A.; Gutiérrez-Sánchez, R.; Guy, L. P.; Haigron, R.; Hatzidimitriou, D.; Haywood, M.; Heiter, U.; Helmi, A.; Hobbs, D.; Hofmann, W.; Holl, B.; Holland, G.; Hunt, J. A. S.; Hypki, A.; Icardi, V.; Irwin, M.; Jevardat de Fombelle, G.; Jofré, P.; Jonker, P. G.; Jorissen, A.; Julbe, F.; Karampelas, A.; Kochoska, A.; Kohley, R.; Kolenberg, K.; Kontizas, E.; Koposov, S. E.; Kordopatis, G.; Koubsky, P.; Kowalczyk, A.; Krone-Martins, A.; Kudryashova, M.; Kull, I.; Bachchan, R. K.; Lacoste-Seris, F.; Lanza, A. F.; Lavigne, J. -B; Le Poncin-Lafitte, C.; Lebreton, Y.; Lebzelter, T.; Leccia, S.; Leclerc, N.; Lecoeur-Taibi, I.; Lemaitre, V.; Lenhardt, H.; Leroux, F.; Liao, S.; Licata, E.; Lindstrøm, H. E. P.; Lister, T. A.; Livanou, E.; Lobel, A.; Löffler, W.; López, M.; Lopez-Lozano, A.; Lorenz, D.; Loureiro, T.; MacDonald, I.; Magalhães Fernandes, T.; Managau, S.; Mann, R. G.; Mantelet, G.; Marchal, O.; Marchant, J. M.; Marconi, M.; Marie, J.; Marinoni, S.; Marrese, P. M.; Marschalkó, G.; Marshall, D. J.; Martín-Fleitas, J. M.; Martino, M.; Mary, N.; Matijevič, G.; Mazeh, T.; McMillan, P. J.; Messina, S.; Mestre, A.; Michalik, D.; Millar, N. R.; Miranda, B. M. H.; Molina, D.; Molinaro, R.; Molinaro, M.; Molnár, L.; Moniez, M.; Montegriffo, P.; Monteiro, D.; Mor, R.; Mora, A.; Morbidelli, R.; Morel, T.; Morgenthaler, S.; Morley, T.; Morris, D.; Mulone, A. F.; Muraveva, T.; Musella, I.; Narbonne, J.; Nelemans, G.; Nicastro, L.; Noval, L.; Ordénovic, C.; Ordieres-Meré, J.; Osborne, P.; Pagani, C.; Pagano, I.; Pailler, F.; Palacin, H.; Palaversa, L.; Parsons, P.; Paulsen, T.; Pecoraro, M.; Pedrosa, R.; Pentikäinen, H.; Pereira, J.; Pichon, B.; Piersimoni, A. M.; Pineau, F. -X; Plachy, E.; Plum, G.; Poujoulet, E.; Prša, A.; Pulone, L.; Ragaini, S.; Rago, S.; Rambaux, N.; Ramos-Lerate, M.; Ranalli, P.; Rauw, G.; Read, A.; Regibo, S.; Renk, F.; Reylé, C.; Ribeiro, R. A.; Rimoldini, L.; Ripepi, V.; Riva, A.; Rixon, G.; Roelens, M.; Romero-Gómez, M.; Rowell, N.; Royer, F.; Rudolph, A.; Ruiz-Dern, L.; Sadowski, G.; Sagristà Sellés, T.; Sahlmann, J.; Salgado, J.; Salguero, E.; Sarasso, M.; Savietto, H.; Schnorhk, A.; Schultheis, M.; Sciacca, E.; Segol, M.; Segovia, J. C.; Segransan, D.; Serpell, E.; Shih, I. -C; Smareglia, R.; Smart, R. L.; Smith, C.; Solano, E.; Solitro, F.; Sordo, R.; Soria Nieto, S.; Souchay, J.; Spagna, A.; Spoto, F.; Stampa, U.; Steele, I. A.; Steidelmüller, H.; Stephenson, C. A.; Stoev, H.; Suess, F. F.; Süveges, M.; Surdej, J.; Szabados, L.; Szegedi-Elek, E.; Tapiador, D.; Taris, F.; Tauran, G.; Taylor, M. B.; Teixeira, R.; Terrett, D.; Tingley, B.; Trager, S. C.; Turon, C.; Ulla, A.; Utrilla, E.; Valentini, G.; van Elteren, A.; Van Hemelryck, E.; van Leeuwen, M.; Varadi, M.; Vecchiato, A.; Veljanoski, J.; Via, T.; Vicente, D.; Vogt, S.; Voss, H.; Votruba, V.; Voutsinas, S.; Walmsley, G.; Weiler, M.; Weingrill, K.; Werner, D.; Wevers, T.; Whitehead, G.; Wyrzykowski, Ł.; Yoldas, A.; Žerjal, M.; Zucker, S.; Zurbach, C.; Zwitter, T.; Alecu, A.; Allen, M.; Allende Prieto, C.; Amorim, A.; Anglada-Escudé, G.; Arsenijevic, V.; Azaz, S.; Balm, P.; Beck, M.; Bernstein, H. -H; Bigot, L.; Bijaoui, A.; Blasco, C.; Bonfigli, M.; Bono, G.; Boudreault, S.; Bressan, A.; Brown, S.; Brunet, P. -M; Bunclark, P.; Buonanno, R.; Butkevich, A. G.; Carret, C.; Carrion, C.; Chemin, L.; Chéreau, F.; Corcione, L.; Darmigny, E.; de Boer, K. S.; de Teodoro, P.; de Zeeuw, P. T.; Delle Luche, C.; Domingues, C. D.; Dubath, P.; Fodor, F.; Frézouls, B.; Fries, A.; Fustes, D.; Fyfe, D.; Gallardo, E.; Gallegos, J.; Gardiol, D.; Gebran, M.; Gomboc, A.; Gómez, A.; Grux, E.; Gueguen, A.; Heyrovsky, A.; Hoar, J.; Iannicola, G.; Isasi Parache, Y.; Janotto, A. -M; Joliet, E.; Jonckheere, A.; Keil, R.; Kim, D. -W; Klagyivik, P.; Klar, J.; Knude, J.; Kochukhov, O.; Kolka, I.; Kos, J.; Kutka, A.; Lainey, V.; LeBouquin, D.; Liu, C.; Loreggia, D.; Makarov, V. V.; Marseille, M. G.; Martayan, C.; Martinez-Rubi, O.; Massart, B.; Meynadier, F.; Mignot, S.; Munari, U.; Nguyen, A. -T; Nordlander, T.; Ocvirk, P.; O'Flaherty, K. S.; Olias Sanz, A.; Ortiz, P.; Osorio, J.; Oszkiewicz, D.; Ouzounis, A.; Palmer, M.; Park, P.; Pasquato, E.; Peltzer, C.; Peralta, J.; Péturaud, F.; Pieniluoma, T.; Pigozzi, E.; Poels, J.; Prat, G.; Prod'homme, T.; Raison, F.; Rebordao, J. M.; Risquez, D.; Rocca-Volmerange, B.; Rosen, S.; Ruiz-Fuertes, M. I.; Russo, F.; Sembay, S.; Serraller Vizcaino, I.; Short, A.; Siebert, A.; Silva, H.; Sinachopoulos, D.; Slezak, E.; Soffel, M.; Sosnowska, D.; Straižys, V.; ter Linden, M.; Terrell, D.; Theil, S.; Tiede, C.; Troisi, L.; Tsalmantza, P.; Tur, D.; Vaccari, M.; Vachier, F.; Valles, P.; Van Hamme, W.; Veltz, L.; Virtanen, J.; Wallut, J. -M; Wichmann, R.; Wilkinson, M. I.; Ziaeepour, H.; Zschocke, S.


    Gaia is a cornerstone mission in the science programme of the EuropeanSpace Agency (ESA). The spacecraft construction was approved in 2006, following a study in which the original interferometric concept was changed to a direct-imaging approach. Both the spacecraft and the payload were built by

  6. The Mothership Mission Architecture (United States)

    Ernst, S. M.; DiCorcia, J. D.; Bonin, G.; Gump, D.; Lewis, J. S.; Foulds, C.; Faber, D.


    The Mothership is considered to be a dedicated deep space carrier spacecraft. It is currently being developed by Deep Space Industries (DSI) as a mission concept that enables a broad participation in the scientific exploration of small bodies - the Mothership mission architecture. A Mothership shall deliver third-party nano-sats, experiments and instruments to Near Earth Asteroids (NEOs), comets or moons. The Mothership service includes delivery of nano-sats, communication to Earth and visuals of the asteroid surface and surrounding area. The Mothership is designed to carry about 10 nano-sats, based upon a variation of the Cubesat standard, with some flexibility on the specific geometry. The Deep Space Nano-Sat reference design is a 14.5 cm cube, which accommodates the same volume as a traditional 3U CubeSat. To reduce cost, Mothership is designed as a secondary payload aboard launches to GTO. DSI is offering slots for nano-sats to individual customers. This enables organizations with relatively low operating budgets to closely examine an asteroid with highly specialized sensors of their own choosing and carry out experiments in the proximity of or on the surface of an asteroid, while the nano-sats can be built or commissioned by a variety of smaller institutions, companies, or agencies. While the overall Mothership mission will have a financial volume somewhere between a European Space Agencies' (ESA) S- and M-class mission for instance, it can be funded through a number of small and individual funding sources and programs, hence avoiding the processes associated with traditional space exploration missions. DSI has been able to identify a significant interest in the planetary science and nano-satellite communities.

  7. The Double Star mission

    Directory of Open Access Journals (Sweden)



    Full Text Available The Double Star Programme (DSP was first proposed by China in March, 1997 at the Fragrant Hill Workshop on Space Science, Beijing, organized by the Chinese Academy of Science. It is the first mission in collaboration between China and ESA. The mission is made of two spacecraft to investigate the magnetospheric global processes and their response to the interplanetary disturbances in conjunction with the Cluster mission. The first spacecraft, TC-1 (Tan Ce means "Explorer", was launched on 29 December 2003, and the second one, TC-2, on 25 July 2004 on board two Chinese Long March 2C rockets. TC-1 was injected in an equatorial orbit of 570x79000 km altitude with a 28° inclination and TC-2 in a polar orbit of 560x38000 km altitude. The orbits have been designed to complement the Cluster mission by maximizing the time when both Cluster and Double Star are in the same scientific regions. The two missions allow simultaneous observations of the Earth magnetosphere from six points in space. To facilitate the comparison of data, half of the Double Star payload is made of spare or duplicates of the Cluster instruments; the other half is made of Chinese instruments. The science operations are coordinated by the Chinese DSP Scientific Operations Centre (DSOC in Beijing and the European Payload Operations Service (EPOS at RAL, UK. The spacecraft and ground segment operations are performed by the DSP Operations and Management Centre (DOMC and DSOC in China, using three ground station, in Beijing, Shanghai and Villafranca.

  8. B plant mission analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.


    This report further develops the mission for B Plant originally defined in WHC-EP-0722, ''System Engineering Functions and Requirements for the Hanford Cleanup Mission: First Issue.'' The B Plant mission analysis will be the basis for a functional analysis that breaks down the B Plant mission statement into the necessary activities to accomplish the mission. These activities are the product of the functional analysis and will then be used in subsequent steps of the systems engineering process, such as identifying requirements and allocating those requirements to B Plant functions. The information in this mission analysis and the functional and requirements analysis are a part of the B Plant technical baseline

  9. Spacelab 3 mission (United States)

    Dalton, Bonnie P.


    Spacelab-3 (SL-3) was the first microgravity mission of extended duration involving crew interaction with animal experiments. This interaction involved sharing the Spacelab environmental system, changing animal food, and changing animal waste trays by the crew. Extensive microbial testing was conducted on the animal specimens and crew and on their ground and flight facilities during all phases of the mission to determine the potential for cross contamination. Macroparticulate sampling was attempted but was unsuccessful due to the unforseen particulate contamination occurring during the flight. Particulate debris of varying size (250 micron to several inches) and composition was recovered post flight from the Spacelab floor, end cones, overhead areas, avionics fan filter, cabin fan filters, tunnel adaptor, and from the crew module. These data are discussed along with solutions, which were implemented, for particulate and microbial containment for future flight facilities.

  10. The THEMIS Mission

    CERN Document Server

    Burch, J. L


    The THEMIS mission aims to determine the trigger and large-scale evolution of substorms by employing five identical micro-satellites which line up along the Earth's magnetotail to track the motion of particles, plasma, and waves from one point to another and for the first time, resolve space-time ambiguities in key regions of the magnetosphere on a global scale. The primary goal of THEMIS is to elucidate which magnetotail process is responsible for substorm onset at the region where substorm auroras map: (i) local disruption of the plasma sheet current (current disruption) or (ii) the interaction of the current sheet with the rapid influx of plasma emanating from reconnection. The probes also traverse the radiation belts and the dayside magnetosphere, allowing THEMIS to address additional baseline objectives. This volume describes the mission, the instrumentation, and the data derived from them.

  11. Cyber Network Mission Dependencies (United States)


    leak paths”) and determine if firewalls and router access control lists are violating network policy. Visualization tools are provided to help analysts...with which a supply agent may not be familiar. In this environment, errors in requisition are easy to make, and they are costly : an incomplete cyber...establishing an email network and recommend a firewall and additional laptops. YMAL would also match mission details like the deployment location with

  12. A Somalia mission experience. (United States)

    Mahomed, Zeyn; Moolla, Muhammad; Motara, Feroza; Laher, Abdullah


    Reports about The Horn of Africa Famine Crisis in 2011 flooded our news bulletins and newspapers. Yet the nations of the world failed to respond and alleviate the unfolding disaster. In August 2011, the Gift of the Givers Foundation mobilised what was to become the largest humanitarian mission ever conducted by an African organisation. Almost a year later, the effort continues, changing the face of disaster medicine as we know it.

  13. The money mission matrix


    Cuperus, Mirthe


    Social entrepreneurship is popular in current academics and other media. This thesis adds to this literature by discovering what the drivers are for sustainable social entrepreneurship. Several stakeholders were identified, creating profiles of the key players in social entrepreneurship. These stakeholders uncovered key factors that represent the drivers for sustainable social entrepreneurship. Key factors were then aligned along the two dimensions: Money and Mission. This crea...

  14. Asteroid Kinetic Impactor Missions (United States)

    Chesley, Steven


    Asteroid impact missions can be carried out as a relatively low-cost add-ons to most asteroid rendezvous missions and such impact experiments have tremendous potential, both scientifically and in the arena of planetary defense.The science returns from an impactor demonstration begin with the documentation of the global effects of the impact, such as changes in orbit and rotation state, the creation and dissipation of an ejecta plume and debris disk, and morphological changes across the body due to the transmission of seismic waves, which might induce landslides and toppling of boulders, etc. At a local level, an inspection of the impact crater and ejecta blanket reveals critical material strength information, as well as spectral differences between the surface and subsurface material.From the planetary defense perspective, an impact demonstration will prove humankind’s capacity to alter the orbit of a potentially threatening asteroid. This technological leap comes in two parts. First, terminal guidance systems that can deliver an impactor with small errors relative to the ~100-200 meter size of a likely impactor have yet to be demonstrated in a deep space environment. Second, the response of an asteroid to such an impact is only understood theoretically due to the potentially significant dependence on the momentum carried by escaping ejecta, which would tend to enhance the deflection by tens of percent and perhaps as much as a factor of a few. A lack of validated understanding of momentum enhancement is a significant obstacle in properly sizing a real-world impactor deflection mission.This presentation will describe the drivers for asteroid impact demonstrations and cover the range of such concepts, starting with ESA’s pioneering Don Quijote mission concept and leading to a brief description of concepts under study at the present time, including the OSIRIS-REx/ISIS, BASiX/KIX and AIM/DART (AIDA) concepts.

  15. The Gaia mission


    Prusti, T.; de Bruijne, J. H. J.; Brown, A. G. A.; Vallenari, A.; Babusiaux, C.; Bailer-Jones, C. A. L.; Bastian, U.; Biermann, M.; Evans, D. W.; Eyer, L.; Jansen, F.; Jordi, C.; Klioner, S. A.; Lammers, U.; Lindegren, L.


    Gaia is a cornerstone mission in the science programme of the European Space Agency (ESA). The spacecraft construction was approved in 2006, following a study in which the original interferometric concept was changed to direct-imaging approach. Both the spacecraft and the payload were built by European industry. The involvement of the scientific community focusses on data processing for which the international Gaia Data Processing and Analysis Consortium (DPAC) was selected in 2007. Gaia wa...

  16. Nanosatellite missions - the future (United States)

    Koudelka, O.; Kuschnig, R.; Wenger, M.; Romano, P.


    In the beginning, nanosatellite projects were focused on educational aspects. In the meantime, the technology matured and now allows to test, demonstrate and validate new systems, operational procedures and services in space at low cost and within much shorter timescales than traditional space endeavors. The number of spacecraft developed and launched has been increasing exponentially in the last years. The constellation of BRITE nanosatellites is demonstrating impressively that demanding scientific requirements can be met with small, low-cost satellites. Industry and space agencies are now embracing small satellite technology. Particularly in the USA, companies have been established to provide commercial services based on CubeSats. The approach is in general different from traditional space projects with their strict product/quality assurance and documentation requirements. The paper gives an overview of nanosatellite missions in different areas of application. Based on lessons learnt from the BRITE mission and recent developments at TU Graz (in particular the implementation of the OPS-SAT nanosatellite for ESA), enhanced technical possibilities for a future astronomy mission after BRITE will be discussed. Powerful on-board computers will allow on-board data pre-processing. A state-of-the-art telemetry system with high data rates would facilitate interference-free operations and increase science data return.

  17. Dawn Mission Update (United States)

    Sykes, M. V.; Russell, C. T.; Coradini, A.; Christensen, U.; de Sanctis, M. C.; Feldman, W. C.; Jaumann, R.; Keller, U.; Konopliv, A. S.; McCord, T. B.; McFadden, L. A.; McSween, H. Y.; Mottola, S.; Neukum, G.; Pieters, C. M.; Prettyman, T. H.; Raymond, C. A.; Smith, D. E.; Williams, B. G.; Wise, J.; Zuber, M. T.


    Dawn, the ninth Discovery mission, will be the first spacecraft to rendezvous with two solar system bodies, the main belt asteroids Vesta and Ceres. This is made possible by utilizing ion propulsion to reach its targets and to maneuver into (and depart) orbits about these bodies. Vesta and Ceres are two terrestrial protoplanets that have survived since the earliest epoch of the solar system and will provide important insights into planet building processes and their evolution under very different circumstances, with and without water. Dawn carries a double framing camera, a visible and infrared mapping spectrometer, and a gamma ray and neutron detector. At Vesta our studies will include the volcanic emplacement of basalts, its differentiation, the possible exposure of its interior near the south pole. At Ceres our studies will include the role of water in its evolution, hydration processes on its surface, and the possible existence of a subsurface ocean. The mission has passed its critical design review and is scheduled to be launched in June 2006 with arrival at Vesta in 2011 and Ceres in 2015. Operation strategies will be presented. Groundbased observations of Vesta, Ceres, and Vesta family members over broad wavelengths, periods and phases will play an important role in detailed mission planning.

  18. Landsat Data Continuity Mission (United States)



    The Landsat Data Continuity Mission (LDCM) is a partnership formed between the National Aeronautics and Space Administration (NASA) and the U.S. Geological Survey (USGS) to place the next Landsat satellite in orbit in January 2013. The Landsat era that began in 1972 will become a nearly 41-year global land record with the successful launch and operation of the LDCM. The LDCM will continue the acquisition, archiving, and distribution of multispectral imagery affording global, synoptic, and repetitive coverage of the Earth's land surfaces at a scale where natural and human-induced changes can be detected, differentiated, characterized, and monitored over time. The mission objectives of the LDCM are to (1) collect and archive medium resolution (30-meter spatial resolution) multispectral image data affording seasonal coverage of the global landmasses for a period of no less than 5 years; (2) ensure that LDCM data are sufficiently consistent with data from the earlier Landsat missions in terms of acquisition geometry, calibration, coverage characteristics, spectral characteristics, output product quality, and data availability to permit studies of landcover and land-use change over time; and (3) distribute LDCM data products to the general public on a nondiscriminatory basis at no cost to the user.

  19. The Spartan 1 mission (United States)

    Cruddace, Raymond G.; Fritz, G. G.; Shrewsberry, D. J.; Brandenstein, D. J.; Creighton, D. C.; Gutschewski, G.; Lucid, S. W.; Nagel, J. M.; Fabian, J. M.; Zimmerman, D.


    The first Spartan mission is documented. The Spartan program, an outgrowth of a joint Naval Research Laboratory (NRL)/National Aeronautics and Space Administration (NASA)-Goddard Space Flight Center (GSFC) development effort, was instituted by NASA for launching autonomous, recoverable payloads from the space shuttle. These payloads have a precise pointing system and are intended to support a wide range of space-science observations and experiments. The first Spartan, carrying an NRL X-ray astronomy instrument, was launched by the orbiter Discovery (STS51G) on June 20, 1985 and recovered successfully 45 h later, on June 22. During this period, Spartan 1 conducted a preprogrammed series of observations of two X-ray sources: the Perseus cluster of galaxies and the center of our galaxy. The mission was successful from both on engineering and a scientific viewpoint. Only one problem was encountered, the attitude control system (ACS) shut down earlier than planned because of high attitude control system gas consumption. A preplanned emergency mode then placed Spartan 1 into a stable, safe condition and allowed a safe recovery. The events are described of the mission and presents X-ray maps of the two observed sources, which were produced from the flight data.

  20. SPICE for ESA Planetary Missions (United States)

    Costa, M.


    The ESA SPICE Service leads the SPICE operations for ESA missions and is responsible for the generation of the SPICE Kernel Dataset for ESA missions. This contribution will describe the status of these datasets and outline the future developments.

  1. Mission Critical Occupation (MCO) Charts (United States)

    Office of Personnel Management — Agencies report resource data and targets for government-wide mission critical occupations and agency specific mission critical and/or high risk occupations. These...

  2. Aging and ABO blood type influence von Willebrand factor and factor VIII levels through interrelated mechanisms. (United States)

    Albánez, S; Ogiwara, K; Michels, A; Hopman, W; Grabell, J; James, P; Lillicrap, D


    Essentials von Willebrand factor (VWF) and factor VIII (FVIII) levels are modulated by age and ABO status. The effect of aging and ABO blood type on VWF and FVIII was assessed in 207 normal individuals. Aging and ABO blood type showed combined and bidirectional influences on VWF and FVIII levels. Aging and ABO blood type influence VWF levels through both secretion and clearance mechanisms. Background The effect of aging and ABO blood type on plasma levels of von Willebrand factor (VWF) and factor VIII (FVIII) have been widely reported; however, a comprehensive analysis of their combined effect has not been performed and the mechanisms responsible for the age-related changes have not been determined. Objectives To assess the influence of aging and ABO blood type on VWF and FVIII levels, and to evaluate the contribution of VWF secretion and clearance to the age-related changes. Methods A cross-sectional observational study was performed in a cohort of 207 normal individuals, whose levels of VWF, FVIII, VWF propeptide (VWFpp), VWFpp/VWF:Ag ratio and blood type A antigen content on VWF (A-VWF) were quantified. Results Aging and ABO blood type exerted interrelated effects on VWF and FVIII plasma levels, because the age-related increase in both proteins was significantly higher in type non-O individuals (β = 0.011 vs. 0.005). This increase with age in non-O subjects drove the differences between blood types in VWF levels, as the mean difference increased from 0.13 U/mL in the young to 0.57 U/mL in the old. Moreover, A-VWF was associated with both VWF antigen (β = 0.29; 95% confidence interval [CI], 0.09, 0.50) and VWF clearance (β = -0.15; 95% CI, -0.25, -0.06). We also documented an effect of ABO blood type on VWF secretion with aging, as old individuals with blood type non-O showed higher levels of VWFpp (mean difference 0.29 U/mL). Conclusions Aging and ABO blood type have an interrelated effect on VWF and FVIII levels, where the effect of one is significantly

  3. Potential role of a new PEGylated recombinant factor VIII for hemophilia A

    Directory of Open Access Journals (Sweden)

    Wynn TT


    Full Text Available Tung Thanh Wynn,1 Burak Gumuscu,2,3 1Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Florida, Gainesville, FL, 2Pediatric Hematology-Oncology, Bon Secours Health System, St. Mary’s Hospital, Richmond, VA, 3Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Virginia, Charlottesville, VA, USA Abstract: Hemophilia A, a deficiency in the activity of coagulation factor (F VIII, is an X-linked bleeding disorder with an approximate incidence of one in 5,000 male infants. Bleeding-related complications often result in greater severity of disease, poor quality of life, surgical interventions for severe joint destruction, and shortened life span. With the availability of plasma-derived and recombinant FVIII products, the benefits of primary prophylaxis were demonstrated and is now the standard of care for patients with severe factor deficiencies. Current hemophilia research is focusing on the creation of new factor replacement therapies with longer half-lives; accessing alternative mechanisms to achieve desired hemostasis and enhance bypassing ­activity; and limiting the immunogenicity of the protein. PEGylation involves the covalent attachment of polyethylene glycol (PEG to a protein, peptide, or a small molecule drug. PEG effectively increases the molecular weight and size of the protein by creating a hydrophilic cloud around the molecule. This molecular change may reduce susceptibility of the molecule to proteolytic activity and degradation. It is also believed that PEGylation changes the surface charge of the protein that ultimately interferes with some receptor-mediated clearance processes. The half-life of PEGylated factor is more prolonged when compared to non-PEGylated full-length recombinant FVIII. The dawn of a new era in the care of hemophilia patients is upon us with the release of recombinant FVIII products with extended half-lives, and products with even more extended half

  4. Pengembangan Perangkat Pembelajaran Matematika Berbasis Concept Attainment Model (CAM untuk Peserta Didik Kelas VIII SMP

    Directory of Open Access Journals (Sweden)

    Eka Jihadah Syaspasbandah


    Full Text Available Penelitian ini merupakan penelitian pengembangan yang bertujuan untuk menghasilkan perangkat pembelajaran matematika berbasis Concept Attainment Model (CAM yang valid, praktis, dan efektif terhadap hasil belajar dan aktivitas peserta didik SMP kelas VIII. Perangkat pembelajaran yang dikembangkan mengikuti prosedur pengembangan Model Plomp yang terdiri dari 3 tahap, yaitu tahap analisis pendahuluan, tahap pengembangan atau pembuatan prototipe, dan tahap penilaian. Uji validitas perangkat pembelajaran dilakukan oleh lima orang ahli dari bidang matematika, teknologi pendidikan, dan bahasa Indonesia. Pengujian kepraktisan perangkat pembelajaran diukur dari tiga hal yaitu: keterlaksanaan perangkat pembelajaran, respon peserta didik, dan respon guru. Untuk menilai efektifitas perangkat pembelajaran, dilakukan dengan mengumpulkan data melalui pengamatan terhadap aktivitas belajar matematika peserta didik selama kegiatan pembelajaran dan nilai tes hasil belajar matematika peserta didik. Hasil pegujian tersebut mengidentifikasi bahwa perangkat pembelajaran matematika berbasis CAM yang dikembangkan dinyatakan valid menurut para ahli, praktis berdasarkan guru dan peserta didik sebagai pengguna, dan efektif terlihat dari aktivitas peserta didik selama proses pembelajaran yang mengalami peningkatan. Kata kunci: penelitian pengembangan, Concept Attainment Model, hasil belajar, aktivitas belajar, Model Plomp   ABSTRACT This research is development research aims to produces mathematics learning equipment based on valid, practical, and effective CAM for learning outcome and students activity of VIII grade junior high school. The developed learning equipment uses the procedure of Plomp Model that consists of 3 stages, they are preliminary research, development or prototyping phase, and assessment phase. Validity test of learning equipment is done by 5 experts from mathematics, eduaction technology, and indonesian language. Practical learning equipment test is


    Directory of Open Access Journals (Sweden)

    Apri Dwi Astuti


    Full Text Available Kemandirian belajar membantu siswa untuk bertanggung jawab dan menumbuhkan kesadaran belajar. Penggunaan uang saku menumbuhkan jiwa mandiri, jujur dan komitmen. Adapun hasil observasi awal menunjukkan masih ada siswa kels VII dan VIII SMP Semesta untuk kompetensi dasar ekonomi dibawah KKM. Tujuan penelitian ini untuk mengetahui pengaruh kemandirian belajar dn penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta. Populasi penelitian ini adalah semua siswa kelas VII dan VIII SMP Semesta Boarding School Semarang. Variabel penelitian ini adalah kemandirian belajar dan penggunaan uang saku sebagai variabel bebas, sedangkan untuk� variabel terikat adalah prestasi belajar kompetensi dasar ekonomi. Data diambil dengan metode wawancara, kuesioner dan dokumentasi guru. Analisis data menggunakan analisis regresi linear berganda.Berdasarkan penelitian secara simultan menunjukkan adanya pengaruh antara kemandirian belajar dan penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi sebesar 51,3%. Secara parsial, pengaruh kemandirian belajar terhadap prestasi belajar kompetensi dasar ekonomi sebesar 66,2% dan pengaruh penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi sebesar 62,5%.Berdasarkan hasil penelitian diatas disimpulkan bahwa kemandirian belajar dan penggunaan uang saku berpengaruh positif baik secara simultan maupun parsial terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta Boarding school semarang tahun pelajaran 2011/2012. Saran yang berkaitan dengan penelitian ini yaitu : 1 Sekolah disarankan untuk memberikan batasan siswa pulang ke rumah agar dapat membantu siswa beradaptasi dengan cepat dan mudah tinggal di asrama. 2 Orang tua disarankan untuk memberikan uang saku yang disesuaikan dengan kebutuhan siswa. 3 Siswa disarankan untuk meningkatkan kemandirian dalam aspek belajar terutama bagi mata pelajaran yang masih kurang dari

  6. Penerapan Model Learning Cycle 5E untuk Meningkatkan Keterampilan Berpikir Kritis Siswa Pada Materi Fluida Statis Kelas VIII

    Directory of Open Access Journals (Sweden)

    Irhamna Irhamna


    Full Text Available Penerapan model learning cycle 5E telah dilakukan pada siswa kelas VIII dengan materi fluida statis. Penelitian ini bertujuan untuk mendapatkan gambaran mengenai peningkatan keterampilan berpikir kritis siswa setelah diterapkan model learning cycle 5E pada materi fluida statis. Bentuk desain penelitian yang digunakan adalah pre-experimental dengan one group pre-test post-test design. Populasi pada penelitian ini adalah seluruh siswa kelas VIII di SMP Torsina Singkawang. Teknik pengambilan sampel menggunakan sampling purposive yang berjumlah 23 orang. Hasil penelitian menunjukkan bahwa model learning cyle 5E dapat meningkatkan keterampilan berpikir kritis siswa yaitu pada indikator pemecahan masalah dengan skor N-gain sebesar 0,43 dengan kategori sedang, indikator membuat keputusan dengan skor N-gain sebesar 0,42 dengan kategori sedang, indikator penyelidikan percobaan dengan skor N-gain sebesar 0,33 dengan kategori sedang dan indikator menyimpulkan dengan skor N-gain sebesar 0,37 dengan kategori sedang.

  7. Structure and stability of hexa-aqua V(III) cations in vanadium redox flow battery electrolytes. (United States)

    Vijayakumar, M; Li, Liyu; Nie, Zimin; Yang, Zhenguo; Hu, JianZhi


    The vanadium(III) cation structure in mixed acid based electrolyte solution from vanadium redox flow batteries is studied by (17)O and (35/37)Cl nuclear magnetic resonance (NMR) spectroscopy, electronic spectroscopy and density functional theory (DFT) based computational modelling. Both computational and experimental results reveal that the V(III) species can complex with counter anions (sulfate/chlorine) depending on the composition of its solvation sphere. By analyzing the powder precipitate it was found that the formation of sulfate complexed V(III) species is the crucial process in the precipitation reaction. The precipitation occurs through nucleation of neutral species formed through deprotonation and ion-pair formation process. However, the powder precipitate shows a multiphase nature which warrants multiple reaction pathways for precipitation reaction.

  8. An immunoradiometric assay for procoagulant factor VIII antigen: results in haemophilia, von Willebrand's disease and fetal plasma and serum

    International Nuclear Information System (INIS)

    Peake, I.R.; Bloom, A.L.; Giddings, J.C.; Ludlam, C.A.


    An immunoradiometric assay (IRMA) has been developed based on the inhibitor which arose in a polytransfused severe haemophiliac. The two-site IRMA measured antigens closely associated with the procoagulant parts of the factor VIII complex, which are termed FVIIIC antigens or FVIIICAG. FVIIICAG was present in normal plasma and also, at a slightly lower concentration, in normal serum. In 37 patients with haemophilia A, 36 had FVIIICAG levels of less than 10% of the normal plasma pool. In patients with von Willebrand's disease the levels of FVIIIC and FVIIICAG were in good agreement, both before and after treatment with cryoprecipitate or DDAVP. FVIIICAG was relatively stable in plasma at 37 0 C and could also be detected in cord and fetal serum. The assay is of potential value for detecting reduced levels of factor VIII, for carrier detection and for the prenatal diagnosis of haemophilia. (author)

  9. Influence Model Assisted Learning Cycle Mind Map to Achievement Physics Laboratory Judging from the performance Grade VIII SMPN 1 Rejoso Pasuruan


    Ary Analisa Rahma


    Pengaruh Model Siklus Belajar Berbantuan Mind Map terhadap Prestasi Belajar Fisika Ditinjau dari Kinerja Laboratorium Siswa Kelas VIII SMPN 1 Rejoso Kabupaten Pasuruan Abstract: This study aimed to examine the effect of the learning cycle models aided the mind map on the learning achievement in terms of the performance of laboratory physics class VIII student on light material in SMP Negeri 1 Rejoso Pasuruan. This study is a quasi-experimental research. The research design used is a 2 x 2...

  10. Penggunaan Media Presentase Microsoft Power Point Untuk Meningkatkan Hasil Belajar IPS Terpadu Pada Siswa Kelas VIII a SMP Negeri 2 Tanantovea


    Hitler, Ahmad


    Permasalahan yang diangkat dalam penelitian adalah apakah dengan penggunaan media Presentase Microsoft Power Point pada mata pembelajaran IPS Terpadu dapat meningkatkan hasil belajar siswa kelas VIII A di SMP Negeri 2 Tanantovea. Penelitian ini bertujuan untuk meningkatkan hasil belajar siswa pada pokok bahasan Kolonialisme dan Imperialisme Barat di kelas VIII A SMP Negeri 2 Tanantovea. Penelitian ini dilakukan dalam 2 siklus, setiap siklus terdiri dari perencanaan, pelaksanaan tindakan, obs...

  11. Efficacy and safety of rVIII-SingleChain: results of a phase 1/3 multicenter clinical trial in severe hemophilia A (United States)

    Mahlangu, Johnny; Kuliczkowski, Kazimierz; Karim, Faraizah Abdul; Stasyshyn, Oleksandra; Kosinova, Marina V.; Lepatan, Lynda Mae; Skotnicki, Aleksander; Boggio, Lisa N.; Klamroth, Robert; Oldenburg, Johannes; Hellmann, Andrzej; Santagostino, Elena; Baker, Ross I.; Fischer, Kathelijn; Gill, Joan C.; P’Ng, Stephanie; Chowdary, Pratima; Escobar, Miguel A.; Khayat, Claudia Djambas; Rusen, Luminita; Bensen-Kennedy, Debra; Blackman, Nicole; Limsakun, Tharin; Veldman, Alex; St. Ledger, Katie


    Recombinant VIII (rVIII)-SingleChain is a novel B-domain–truncated recombinant factor VIII (rFVIII), comprised of covalently bonded factor VIII (FVIII) heavy and light chains. It was designed to have a higher binding affinity for von Willebrand factor (VWF). This phase 1/3 study investigated the efficacy and safety of rVIII-SingleChain in the treatment of bleeding episodes, routine prophylaxis, and surgical prophylaxis. Participants were ≥12 years of age, with severe hemophilia A (endogenous FVIII <1%). The participants were allocated by the investigator to receive rVIII-SingleChain in either an on-demand or prophylaxis regimen. Of the 175 patients meeting study eligibility criteria, 173 were treated with rVIII-SingleChain, prophylactically (N = 146) or on-demand (N = 27). The total cumulative exposure was 14 306 exposure days (EDs), with 120 participants reaching ≥50 EDs and 52 participants having ≥100 EDs. Hemostatic efficacy was rated by the investigator as excellent or good in 93.8% of the 835 bleeds treated and assessed. Across all prophylaxis regimens, the median annualized spontaneous bleeding rate was 0.00 (Q1, Q3: 0.0, 2.4) and the median overall annualized bleeding rate (ABR) was 1.14 (Q1, Q3: 0.0, 4.2). Surgical hemostasis was rated as excellent/good in 100% of major surgeries by the investigator. No participant developed FVIII inhibitors. In conclusion, rVIII-SingleChain is a novel rFVIII molecule showing excellent hemostatic efficacy in surgery and in the control of bleeding events, low ABR in patients on prophylaxis, and a favorable safety profile in this large clinical study. This trial was registered at as #NCT01486927. PMID:27330001

  12. Development of Integrated Natural Science Teaching Materials Webbed Type with Applying Discourse Analysis on Students Grade VIII in Physics Class (United States)

    Sukariasih, Luh


    This study aims to produce teaching materials integrated natural science (IPA) webbed type of handout types are eligible for use in integrated science teaching. This type of research IS a kind of research and development / Research and Development (R & D) with reference to the 4D development model that is (define, design, develop, and disseminate). Data analysis techniques used to process data from the results of the assessment by the validator expert, and the results of the assessment by teachers and learners while testing is limited (12 students of class VIII SMPN 10 Kendari) using quantitative descriptive data analysis techniques disclosed in the distribution of scores on the scale of five categories grading scale that has been determined. The results of due diligence material gain votes validator material in the category of “very good” and “good”, of the data generated in the feasibility test presentation obtained the category of “good” and “excellent”, from the data generated in the feasibility of graphic test obtained the category of “very good “and” good “, as well as of the data generated in the test the feasibility of using words and language obtained the category of“very good “and” good “, so with qualifications gained the teaching materials IPA integrated type webbed by applying discourse analysis on the theme of energy and food for Junior High School (SMP) grade VIII suitable as teaching materials. In limited testing, data generated in response to a science teacher at SMPN 10 Kendari to product instructional materials as “excellent”, and from the data generated while testing is limited by the 12 students of class VIII SMPN 10 Kendari are more students who score indicates category “very good”, so that the qualification obtained by the natural science (IPA) teaching material integrated type webbed by applying discourse analysis on the theme of energy and food for SMP / class VIII fit for use as teaching material.

  13. The Funnel Geometry of Open Flux Tubes in the Low Solar Corona Constrained by O VI and Ne VIII Outflow (United States)

    Byhring, Hanne S.; Esser, Ruth; Lie-Svendsen, Oystein


    Model calculations show that observed outflow velocities of order 7-10 km/s of C IV and O VI ions, and 15-20 km/s of Ne VIII ions, are not only consistent with models of the solar wind from coronas holes, but also place unique constraints on the degree of flow tube expansion as well as the location of the expansion in the transition region/lower corona.

  14. Neurotology findings in patients with diagnosis of vascular loop of cranial nerves VIII in magnetic resonance imaging

    Directory of Open Access Journals (Sweden)

    Grocoske, Francisco Luiz Busato

    Full Text Available Introduction: The vascular compression by redundant vessels under the VIII cranial nerves has been studied since the 80's, and many authors proposed correlations between the compression and the otoneurological findings (vertigo, tinnitus, hypoacusis, audiometry and electrophysiological findings. Objective: Analyze and correlate the different signs and otoneurological symptoms, the audiological findings and its incidence over individuals with Vascular Loop (VL diagnosis of VIII cranial nerves by magnetic resonance imaging (MRI. Method: Retrospective study through the analysis of medical records of 47 patients attended in the otoneurology clinic of Clinical Hospital of UFPR. All the patients have MRI exams with compatible pictures of VL of the VIII cranial nerves. Results: The tinnitus was the most frequent symptom, in 83% of the patients, followed by hypoacusis (60% and vertigo (36%. The audiometry presented alterations in 89%, the brainstem evoked auditory potential in 33% and the vecto-electronystagmography in 17% of the patients. Was not found statistically significant relation between the buzz or hypoacusis, and the presence of VL in MRI. Only 36% of patients had complaints of vertigo, the main symptom described in theory of vascular compression of the VIII pair of nerve. As in the audiometry and in brainstem evoked auditory potential was not found a statistically significant relation between the exam and the presence of the VL in the RMI. Conclusion: The results show independence between the findings of the RMI, clinical picture and audiological results (p>0,05 suggesting that there are no exclusive and direct relation between the diagnosis of vascular loop in the MRI and the clinical picture matching.

  15. Fluid-phase immunoradiometric assay for the detection of qualitative abnormalities of factor VIII/von Willebrand factor in variants of von Willebrand's disease

    International Nuclear Information System (INIS)

    Girma, J.P.; Ardaillou, N.; Meyer, D.; Lavergne, J.M.; Larrieu, M.J.


    Antigenic reactivity of F.VIII/WF in variants of von Willebrand's disease (vWd) was studied with both fluid-phase and solid-phase immunoradiometric assays. Two different (rabbit and goat) 125 I-labeled specific antibodies against purified F.VIII/WF were used in both their divalent (lgG) and their monovalent (Fab fragment) forms. Dose-response curves obtained by reacting a constant amount of antibody with serial dilutions of plasmas from normal or homozygous vWd demonstrated the specificity of the test. The accuracy was significantly higher with 125 I-Fab fragments of goat anti-F.VIII/WF antiserum than intact goat lgG or rabbit lgG or Fab fragments. The significant decrease of the slope of the dose-response curves obtained with plasma from variants of vWd has been interpreted as due to the presence of abnormal F.VIII/WF molecules with decreased antigenic reactivity. A similar anomaly was found in cryosupernatant prepared from normal plasma, paralleling similarities demonstrated between variants of vWd and cryosupernatant. Results of experiments performed by reacting constant plasma dilutions from control or variants of vWd and varying concentrations of anti-F.VIII/WF Fab fragments (rabbit or goat) confirmed the decreased antigenic reactivity of variant F.VIII/WF

  16. Partial correction of a severe molecular defect in hemophilia A, because of errors during expression of the factor VIII gene

    Energy Technology Data Exchange (ETDEWEB)

    Young, M.; Antonarakis, S.E. [Univ. of Geneva (Switzerland); Inaba, Hiroshi [Tokyo Medical College (Japan)] [and others


    Although the molecular defect in patients in a Japanese family with mild to moderately severe hemophilia A was a deletion of a single nucleotide T within an A{sub 8}TA{sub 2} sequence of exon 14 of the factor VIII gene, the severity of the clinical phenotype did not correspond to that expected of a frameshift mutation. A small amount of functional factor VIII protein was detected in the patient`s plasma. Analysis of DNA and RNA molecules from normal and affected individuals and in vitro transcription/translation suggested a partial correction of the molecular defect, because of the following: (i) DNA replication/RNA transcription errors resulting in restoration of the reading frame and/or (ii) {open_quotes}ribosomal frameshifting{close_quotes} resulting in the production of normal factor VIII polypeptide and, thus, in a milder than expected hemophilia A. All of these mechanisms probably were promoted by the longer run of adenines, A{sub 10} instead of A{sub 8}TA{sub 2}, after the delT. Errors in the complex steps of gene expression therefore may partially correct a severe frameshift defect and ameliorate an expected severe phenotype. 36 refs., 6 figs.


    Directory of Open Access Journals (Sweden)

    Sri Wahyuni


    Full Text Available Tujuan penelitian ini adalah untuk mengetahui (1 apakah pembelajaran dengan model pembelajaran LAPS-Heuristik pada materi lingkaran kelas-VIII dapat mengembangkan karakter kedisiplinan peserta didik, (2 apakah pembelajaran dengan model pembelajaran LAPS-Heuristik pada materi lingkaran kelas-VIII dapat meningkatkan kemampuan pemecahan masalah peserta didik, (3 apakah kemampuan pemecahan masalah matematika peserta didik yang diajar dengan model pembelajaran LAPS-Heuristik pada materi lingkaran kelas-VIII dapat mencapai kriteria ketuntasan minimal yang ditentukan. Desain penelitian ini adalah kualitatif deskriptif, artinya menggambarkan atau mendeskripsikan kejadian-kejadian yang menjadi pusat perhatian secara kualitatif dan berdasar data kualitatif. Penentuan sumber data dalam penelitian ini menggunakan teknik purposive sampling, yaitu dipilih dengan pertimbangan dan tujuan tertentu. Data diperoleh dengan observasi, wawancara, dan tes yang kemudian dianalisis menggunakan analisis kualitatif dan analisis gain untuk mengukur peningkatan. Analisis kualitatif menunjukkan karakter kedisiplinan dan kemampuan pemecahan masalah peserta didik meningkat, serta kemampuan pemecahan masalah peserta didik mencapai KKM melalui model pembelajaran LAPS-Heuristik.

  18. Manufacturing process used to produce long-acting recombinant factor VIII Fc fusion protein. (United States)

    McCue, Justin; Kshirsagar, Rashmi; Selvitelli, Keith; Lu, Qi; Zhang, Mingxuan; Mei, Baisong; Peters, Robert; Pierce, Glenn F; Dumont, Jennifer; Raso, Stephen; Reichert, Heidi


    Recombinant factor VIII Fc fusion protein (rFVIIIFc) is a long-acting coagulation factor approved for the treatment of hemophilia A. Here, the rFVIIIFc manufacturing process and results of studies evaluating product quality and the capacity of the process to remove potential impurities and viruses are described. This manufacturing process utilized readily transferable and scalable unit operations and employed multi-step purification and viral clearance processing, including a novel affinity chromatography adsorbent and a 15 nm pore size virus removal nanofilter. A cell line derived from human embryonic kidney (HEK) 293H cells was used to produce rFVIIIFc. Validation studies evaluated identity, purity, activity, and safety. Process-related impurity clearance and viral clearance spiking studies demonstrate robust and reproducible removal of impurities and viruses, with total viral clearance >8-15 log10 for four model viruses (xenotropic murine leukemia virus, mice minute virus, reovirus type 3, and suid herpes virus 1). Terminal galactose-α-1,3-galactose and N-glycolylneuraminic acid, two non-human glycans, were undetectable in rFVIIIFc. Biochemical and in vitro biological analyses confirmed the purity, activity, and consistency of rFVIIIFc. In conclusion, this manufacturing process produces a highly pure product free of viruses, impurities, and non-human glycan structures, with scale capabilities to ensure a consistent and adequate supply of rFVIIIFc. Copyright © 2015 Biogen. Published by Elsevier Ltd.. All rights reserved.

  19. Grotrian diagrams of highly ionized iron Fe(VIII)-Fe(XXVI)

    International Nuclear Information System (INIS)

    Mori, Kazuo; Otsuka, Masamoto; Kato, Takako.


    Energy levels and Grotrian diagrams of Fe(VIII) to Fe(XXVI) are presented. This report summarized the data published recently up to 1976, and the wavelength tables compiled were converted to the Grotrian diagrams. The diagrams showing transition from one energy level to another are called Grotrian diagrams. Typical examples of the diagrams are found in the book by Bashkin et al. In the present diagrams, all lines are drawn in parallel, and connected to the extended lines from lower levels. As the results, locally dense packing of lines and figures is avoided. The ordinate of the diagrams indicates level energy, and the J values are shown on the left side of the levels. The wavelength values in angstrom unit are written in parallel with the vertical transition lines. This vertical lines show the resonance transition having absorption oscillator strength f larger than 0.1. The present diagrams are the combination of the tables of wavelength and energy level. Accordingly, the desired wavelength and level energy are easily found. The figures of wavelength are lined up in various groups, so that the characteristics of the transition can be discriminated at a glance. Wavelength and level energy have been mostly derived from experimental spectra in laboratory or solar plasma, except a few by Fawcett's prediction. (Kato, T.)

  20. Synthesis of methyl acetate from dimethyl ether using group VIII metal salts of phosphotungstic acid

    Energy Technology Data Exchange (ETDEWEB)

    Sardesai, A.; Lee, S.; Tartamella, T.


    Dimethyl ether (DME) can be produced much more efficiently in a single-stage, liquid-phase process from natural gas-based syngas as compared to the conventional process via dehydration of methanol. This process, based on dual catalysts slurried in inert oil, alleviates the chemical equilibrium limitation governing the methanol synthesis reaction and concurrently improves per-pass syngas conversion and reactor productivity. The potential, therefore, for production of methyl acetate via dimethyl ether carbonylation is of industrial importance. In the present study, conversion of dimethyl ether and carbon monoxide to methyl acetate is investigated over a variety of group VIII metal-substituted phosphotungstic acid salts. Experimental results of this catalytic reaction using rhodium, iridium, ruthenium, and palladium catalysts are evaluated and compared in terms of selectivity toward methyl acetate. The effects of active metal, support types, multiple metal loading, and feed conditions on carbonylation activity of DME are examined. Iridium metal substituted phosphotungstic acid supported on Davisil type 643 (pore size 150 A, surface area 279 m{sup 2}/g, mesh size 230-425) silica gel shows the highest activity for DME carbonylation. (author)

  1. The spectrum of seven times ionized tungsten (W VIII) relevant to tokamak divertor plasmas

    International Nuclear Information System (INIS)

    Ryabtsev, A N; Kononov, E Ya; Kildiyarova, R R; Tchang-Brillet, W-Ü L; Wyart, J-F


    Tungsten spectra excited in the vacuum sparks of different setups and electric circuits were recorded on two high-resolution vacuum spectrographs. For the region 190–500 Å, a 10 m normal incidence spectrograph with a 3600 lines/mm grating was used in the Meudon Observatory. In the region below 350 Å, a set of spectra was produced using a 3 m grazing incidence spectrograph with a 3600 lines/mm grating in the Institute of Spectroscopy in Troitsk. A total of 187 lines in the region 160–271 Å were identified as transitions to the low-lying odd configurations 4f 13 5s 2 5p 6 and 4f 14 5s 2 5p 5 from the interacting excited even 4f 12 5s 2 5p 6 5d + 4f 13 5s 2 5p 5 (5d + 6s) + 4f 14 5s 2 5p 4 (5d + 6s) + 4f 14 5s5p 6 configurations. It was found that 4f 13 5s 2 5p 6 2 F 7/2 is the ground level of W VIII. The fine structure splitting and relative positions of the odd terms were established, and 98 levels of the excited even configurations were found. (paper)

  2. Extracorporeal adsorption of anti-factor VIII allo-antibodies on randomly functionalized polystyrene resins. (United States)

    Huguet, Hélène-Céline; Lasne, Dominique; Rothschild, Chantal; Siali, Rosa; Jozefonvicz, Jacqueline


    The occurrence of anti-factor VIII (FVIII) allo-antibodies is a severe complication of the treatment of haemophilia A patients, leading to the inhibition of transfused FVIII activity. The effective elimination of these inhibitory antibodies plays a decisive role in the management of affected patients. To achieve this, immunoadsorption devices employing synthetic adsorbers, which selectively eliminate inhibitors, are of interest in the treatment strategy of haemophilia A patients with inhibitors. Adsorbers consisting of polystyrene-based beads substituted with sulphonate and L-tyrosyl methylester groups, which mimic part of epitope of FVIII molecule recognized by inhibitors, exhibit selective binding capacities towards anti-FVIII antibodies. The adsorption of FVIII inhibitors was investigated by simulating an extracorporeal circulation of haemophilic plasma over these functionalized resins. These innovative adsorbers are able to remove around 25% of anti-FVIII antibodies in 15 minutes depending on the plasma tested. Furthermore, they do not modify the amount of essential plasmatic proteins or residual immunoglobulins G. Experiments which were carried out using different plasmas with various inhibitor titres demonstrate a good reproducibility regarding the adsorption capacity of the synthetic resin. The characteristics of adsorption are similar on either native or regenerated resins. Both the purely synthetic nature of the resin and its easy processability demonstrate the real advantages over currently available protocols. This synthetic adsorber is a major technological advance in selective removal of FVIII inhibitory antibodies.


    Directory of Open Access Journals (Sweden)

    Rezky Ramadhona


    Full Text Available Penelitian ini bertujuan untuk mengetahui apakah motivasi dan hasil belajar belajar matematika siswa kelas VIII SMPN 1 Sawahlunto setelah menggunakan mind map dan musik klasik lebih baik dari sebelum menggunakan mind map dan musik klasik. Jenis penelitian ini adalah penelitian eksperimen dengan menggunakan dua model rancangan yaitu One Group Pretest Posttest Design untuk melihat dampak perlakuan terhadap motivasi belajar dan Randomized Control Group Only Design untuk melihat dampak perlakuan terhadap hasil belajar. Pengumpulan data dalam penelitian ini menggunakan angket dan tes akhir berupa soal essai. Data yang diperoleh dianalisis dengan menggunakan Uji-t. Hasil penelitian menunjukkan bahwa motivasi belajar matematika siswa cenderung meningkat. Jadi disimpulkan bahwa motivasi belajar matematika siswa setelah menggunakan mind map dan musik klasik lebih baik dari pada sebelum menggunakan mind map dan musik klasik. Dari hasil uji hipotesis untuk data hasil belajar pada selang kepercayaan α = 0,05 diperoleh P-value = 0,022. Jadi dapat disimpulkan bahwa hasil belajar matematika siswa yang menggunakan mind map dan musik klasik lebih baik dari hasil belajar matematika siswa yang tidak menggunakan mind map dan musik klasik. Kata Kunci: Mind Map, Musik Klasik DOI:

  4. Transgenic rabbits as a model organism for production of human clotting factor VIII

    International Nuclear Information System (INIS)

    Vasicek, D.; Chrenek, P.; Makarevich, A.; Bauer, M.; Jurcik, R.; Suvegova, K.; Rafay, J.; Bulla, J.; Hetenyi, L.; Erickson, J.; Paleyanda, R.K.


    Human clotting factor VIII (hFVIII) is a very complex and large protein whose expression is difficult, as hFVIII requires extensive post-translational modification to be biologically active. This paper reports the generation of transgenic rabbits as a model species for testing the expression of hFVIII in the mammary gland. For micro-injection, a fusion gene construct was used, consisting of 2.5 kb murine whey acidic protein (mWAP) promoter, 7.2 kb cDNA of hFVIII, and 4.6 kb of 3' flanking sequences of the mWAP gene. from 130 micro-injected zygotes transferred into recipients, 30 offspring were delivered. The pups were screened for the transgene by PCR, using DNA isolated from the ear, and results were confirmed by Southern blot analysis. The transgene was identified in one female founder animal, and it was transmitted to the offspring in a Mendelian fashion, thus demonstrating stable integration of the gene construct into the germline of the transgenic rabbits. (author)

  5. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. (United States)

    Hsia, Chien-Hsun; Shen, Ming-Ching; Lin, Jen-Shiou; Wen, Yao-Ke; Hwang, Kai-Lin; Cham, Thau-Ming; Yang, Nae-Cherng


    Nattokinase, a serine proteinase from Bacillus subtilis, is considered to be one of the most active functional ingredients found in natto. In this study, we hypothesized that nattokinase could reduce certain factors of blood clotting and lipids that are associated with an increase risk for cardiovascular disease (CVD). Thus, an open-label, self-controlled clinical trial was conducted on subjects of the following groups: healthy volunteers (Healthy Group), patients with cardiovascular risk factors (Cardiovascular Group), and patients undergoing dialysis (Dialysis Group). All subjects ingested 2 capsules of nattokinase (2000 fibrinolysis units per capsule) daily orally for 2 months. The laboratory measurements were performed on the screening visit and, subsequently, regularly after the initiation of the study. The intent-to-treat analysis was performed on all 45 enrolled subjects. By use of mixed model analysis, a significant time effect, but not group effect, was observed in the change from baseline of fibrinogen (P = .003), factor VII (P nattokinase. No significant changes of uric acid or notable adverse events were observed in any of the subjects. In summary, this study showed that oral administration of nattokinase could be considered as a CVD nutraceutical by decreasing plasma levels of fibrinogen, factor VII, and factor VIII.

  6. Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models (United States)

    Siner, Joshua I.; Samelson-Jones, Benjamin J.; Crudele, Julie M.; French, Robert A.; Lee, Benjamin J.; Zhou, Shanzhen; Merricks, Elizabeth; Raymer, Robin; Camire, Rodney M.; Arruda, Valder R.


    Processing by the proprotein convertase furin is believed to be critical for the biological activity of multiple proteins involved in hemostasis, including coagulation factor VIII (FVIII). This belief prompted the retention of the furin recognition motif (amino acids 1645–1648) in the design of B-domain–deleted FVIII (FVIII-BDD) products in current clinical use and in the drug development pipeline, as well as in experimental FVIII gene therapy strategies. Here, we report that processing by furin is in fact deleterious to FVIII-BDD secretion and procoagulant activity. Inhibition of furin increases the secretion and decreases the intracellular retention of FVIII-BDD protein in mammalian cells. Our new variant (FVIII-ΔF), in which this recognition motif is removed, efficiently circumvents furin. FVIII-ΔF demonstrates increased recombinant protein yields, enhanced clotting activity, and higher circulating FVIII levels after adeno-associated viral vector–based liver gene therapy in a murine model of severe hemophilia A (HA) compared with FVIII-BDD. Moreover, we observed an amelioration of the bleeding phenotype in severe HA dogs with sustained therapeutic FVIII levels after FVIII-ΔF gene therapy at a lower vector dose than previously employed in this model. The immunogenicity of FVIII-ΔF did not differ from that of FVIII-BDD as a protein or a gene therapeutic. Thus, contrary to previous suppositions, FVIII variants that can avoid furin processing are likely to have enhanced translational potential for HA therapy. PMID:27734034

  7. The 4p5rd10 and 4d86p configurations of Te VIII

    International Nuclear Information System (INIS)

    Churilov, S.S.; Rossijskaya Akademiya Nauk, Troitsk; Joshi, Y.N.; Kildiyarova, R.R.


    The spectrum of tellurium was photographed in the 100-500 A region on a variety of grazing incidence spectrographs using a triggered spark source. The analysis of the lines in the 117-216 A region has lead to establishing 42 out of 45 levels of the 4d 8 6p configuration of Te VIII. Four levels of the 4d 8 4f configuration were confirmed and their level values revised, and an additional 4d 8 4f level was established. The 4p 5 4d 10 levels reported earlier were found to be erroneous and new values have been found for them. Eighty seven (87) new lines have been classified in the (4d 9 + 4d 8 5s)-(4d 8 4f + 4p 5 4d 10 + 4d 8 6p) transition array. Hartree-Fock with relativistic corrections (HFR) and parametric least-squares-fitted (lSF) calculations were carried out to interpret the present analysis adequately. (orig.)

  8. [Determinants of the elevated factor VIII activity in patients following venous thromboembolism]. (United States)

    Lech, Monika; Kościelniak, Barbara; Bryk, Agata; Undas, Anetta


    Activity of factor VIII (FVIII) increased above 150% of reference range predisposes to venous thromboembolism (VTE). The aim of this study was to identify predictors of increased FVIII activity in patients following VTE. 241 (38% men) patients presented due to objectively documented VTE episode at least 3 months ago were included in this study. FVIII activity was measured using a clotting assay on the analyzer BCS XP. Among 241 patients with VTE, activity of FVIII above 150% (FVIII ≥ 150%) was observed in 96 (40%). These patients were older (p = 0.035) and their concentrations of fibrinogen and C-reactive protein (CRP) were higher by 12% and 88% (p 200%) and this group was also older (p = 0.015), more patients in that group had obesity (p = 0.015), idiopathic VTE (p = 0.043), less of them had positive family history (p = 0.010) and they were characterized by fibrinogen and CRP increased by 28% (p 200% (p = 0.016). The activity of FVIII in patients after VTE episode is influenced by age, concentration of fibrinogen, bilirubin, hemoglobin, glucose, CRP and homocysteine. Our results suggest the role of environmental factors, mainly inflammatory response in maintaining elevated FVIII activity following VTE.

  9. Mission to Planet Earth (United States)

    Tilford, Shelby G.; Asrar, Ghassem; Backlund, Peter W.


    Mission to Planet Earth (MTPE) is NASA's concept for an international science program to produce the understanding needed to predict changes in the Earth's environment. NASA and its interagency and international partners will place satellites carrying advanced sensors in strategic Earth orbits to gather multidisciplinary data. A sophisticated data system will process and archive an unprecedented amount of information about the Earth and how it works as a system. Increased understanding of the Earth system is a basic human responsibility, a prerequisite to informed management of the planet's resources and to the preservation of the global environment.

  10. The ARTEMIS mission

    CERN Document Server

    Angelopoulos, Vassilis


    The ARTEMIS mission was initiated by skillfully moving the two outermost Earth-orbiting THEMIS spacecraft into lunar orbit to conduct unprecedented dual spacecraft observations of the lunar environment. ARTEMIS stands for Acceleration, Reconnection, Turbulence and Electrodynamics of the Moon's Interaction with the Sun. Indeed, this volume discusses initial findings related to the Moon’s magnetic and plasma environments and the electrical conductivity of the lunar interior. This work is aimed at researchers and graduate students in both heliophysics and planetary physics. Originally published in Space Science Reviews, Vol. 165/1-4, 2011.

  11. The solar probe mission

    International Nuclear Information System (INIS)

    Feldman, W.C.; Anderson, J.; Bohlin, J.D.; Burlaga, L.F.; Farquhar, R.; Gloeckler, G.; Goldstein, B.E.; Harvey, J.W.; Holzer, T.E.; Jones, W.V.; Kellogg, P.J.; Krimigis, S.M.; Kundu, M.R.; Lazarus, A.J.; Mellott, M.M.; Parker, E.N.; Rosner, R.; Rottman, G.J.; Slavin, J.A.; Suess, S.T.; Tsurutani, B.T.; Woo, R.T.; Zwickl, R.D.


    The Solar Probe will deliver a 133.5 kg science payload into a 4 R s perihelion solar polar orbit (with the first perihelion passage in 2004) to explore in situ one of the last frontiers in the solar system---the solar corona. This mission is both affordable and technologically feasible. Using a payload of 12 (predominantly particles and fields) scientific experiments, it will be possible to answer many long-standing, fundamental problems concerning the structure and dynamics of the outer solar atmosphere, including the acceleration, storage, and transport of energetic particles near the Sun and in the inner ( s ) heliosphere

  12. Mission to Planet Earth

    International Nuclear Information System (INIS)

    Wilson, G.S.; Backlund, P.W.


    Mission to Planet Earth (MTPE) is NASA's concept for an international science program to produce the understanding needed to predict changes in the earth's environment. NASA and its interagency and international partners will place satellites carrying advanced sensors in strategic earth orbits to gather multidisciplinary data. A sophisticated data system will process and archive an unprecedented amount of information about the earth and how it works as a system. Increased understanding of the earth system is a basic human responsibility, a prerequisite to informed management of the planet's resources and to the preservation of the global environment. 8 refs

  13. STS-61 mission director's post-mission report (United States)

    Newman, Ronald L.


    To ensure the success of the complex Hubble Space Telescope servicing mission, STS-61, NASA established a number of independent review groups to assess management, design, planning, and preparation for the mission. One of the resulting recommendations for mission success was that an overall Mission Director be appointed to coordinate management activities of the Space Shuttle and Hubble programs and to consolidate results of the team reviews and expedite responses to recommendations. This report presents pre-mission events important to the experience base of mission management, with related Mission Director's recommendations following the event(s) to which they apply. All Mission Director's recommendations are presented collectively in an appendix. Other appendixes contain recommendations from the various review groups, including Payload Officers, the JSC Extravehicular Activity (EVA) Section, JSC EVA Management Office, JSC Crew and Thermal Systems Division, and the STS-61 crew itself. This report also lists mission events in chronological order and includes as an appendix a post-mission summary by the lead Payload Deployment and Retrieval System Officer. Recommendations range from those pertaining to specific component use or operating techniques to those for improved management, review, planning, and safety procedures.

  14. Solar maximum mission

    International Nuclear Information System (INIS)

    Ryan, J.


    By understanding the sun, astrophysicists hope to expand this knowledge to understanding other stars. To study the sun, NASA launched a satellite on February 14, 1980. The project is named the Solar Maximum Mission (SMM). The satellite conducted detailed observations of the sun in collaboration with other satellites and ground-based optical and radio observations until its failure 10 months into the mission. The main objective of the SMM was to investigate one aspect of solar activity: solar flares. A brief description of the flare mechanism is given. The SMM satellite was valuable in providing information on where and how a solar flare occurs. A sequence of photographs of a solar flare taken from SMM satellite shows how a solar flare develops in a particular layer of the solar atmosphere. Two flares especially suitable for detailed observations by a joint effort occurred on April 30 and May 21 of 1980. These flares and observations of the flares are discussed. Also discussed are significant discoveries made by individual experiments

  15. The Euclid mission design (United States)

    Racca, Giuseppe D.; Laureijs, René; Stagnaro, Luca; Salvignol, Jean-Christophe; Lorenzo Alvarez, José; Saavedra Criado, Gonzalo; Gaspar Venancio, Luis; Short, Alex; Strada, Paolo; Bönke, Tobias; Colombo, Cyril; Calvi, Adriano; Maiorano, Elena; Piersanti, Osvaldo; Prezelus, Sylvain; Rosato, Pierluigi; Pinel, Jacques; Rozemeijer, Hans; Lesna, Valentina; Musi, Paolo; Sias, Marco; Anselmi, Alberto; Cazaubiel, Vincent; Vaillon, Ludovic; Mellier, Yannick; Amiaux, Jérôme; Berthé, Michel; Sauvage, Marc; Azzollini, Ruyman; Cropper, Mark; Pottinger, Sabrina; Jahnke, Knud; Ealet, Anne; Maciaszek, Thierry; Pasian, Fabio; Zacchei, Andrea; Scaramella, Roberto; Hoar, John; Kohley, Ralf; Vavrek, Roland; Rudolph, Andreas; Schmidt, Micha


    Euclid is a space-based optical/near-infrared survey mission of the European Space Agency (ESA) to investigate the nature of dark energy, dark matter and gravity by observing the geometry of the Universe and on the formation of structures over cosmological timescales. Euclid will use two probes of the signature of dark matter and energy: Weak gravitational Lensing, which requires the measurement of the shape and photometric redshifts of distant galaxies, and Galaxy Clustering, based on the measurement of the 3-dimensional distribution of galaxies through their spectroscopic redshifts. The mission is scheduled for launch in 2020 and is designed for 6 years of nominal survey operations. The Euclid Spacecraft is composed of a Service Module and a Payload Module. The Service Module comprises all the conventional spacecraft subsystems, the instruments warm electronics units, the sun shield and the solar arrays. In particular the Service Module provides the extremely challenging pointing accuracy required by the scientific objectives. The Payload Module consists of a 1.2 m three-mirror Korsch type telescope and of two instruments, the visible imager and the near-infrared spectro-photometer, both covering a large common field-of-view enabling to survey more than 35% of the entire sky. All sensor data are downlinked using K-band transmission and processed by a dedicated ground segment for science data processing. The Euclid data and catalogues will be made available to the public at the ESA Science Data Centre.

  16. EU Universities’ Mission Statements

    Directory of Open Access Journals (Sweden)

    Liudmila Arcimaviciene


    Full Text Available In the last 10 years, a highly productive space of metaphor analysis has been established in the discourse studies of media, politics, business, and education. In the theoretical framework of Conceptual Metaphor Theory and Critical Discourse Analysis, the restored metaphorical patterns are especially valued for their implied ideological value as realized both conceptually and linguistically. By using the analytical framework of Critical Metaphor Analysis and procedurally employing Pragglejaz Group’s Metaphor Identification Procedure, this study aims at analyzing the implied value of the evoked metaphors in the mission statements of the first 20 European Universities, according to the Webometrics ranking. In this article, it is proposed that Universities’ mission statements are based on the positive evaluation of the COMMERCE metaphor, which does not fully correlate with the ideological framework of sustainability education but is rather oriented toward consumerism in both education and society. Despite this overall trend, there are some traceable features of the conceptualization reflecting the sustainability approach to higher education, as related to freedom of speech, tolerance, and environmental concerns. Nonetheless, these are suppressed by the metaphoric usages evoking traditional dogmas of the conservative ideology grounded in the concepts of the transactional approach to relationship, competitiveness for superiority, the importance of self-interest and strength, and quantifiable quality.

  17. OMV mission simulator (United States)

    Cok, Keith E.


    The Orbital Maneuvering Vehicle (OMV) will be remotely piloted during rendezvous, docking, or proximity operations with target spacecraft from a ground control console (GCC). The real-time mission simulator and graphics being used to design a console pilot-machine interface are discussed. A real-time orbital dynamics simulator drives the visual displays. The dynamics simulator includes a J2 oblate earth gravity model and a generalized 1962 rotating atmospheric and drag model. The simulator also provides a variable-length communication delay to represent use of the Tracking and Data Relay Satellite System (TDRSS) and NASA Communications (NASCOM). Input parameter files determine the graphics display. This feature allows rapid prototyping since displays can be easily modified from pilot recommendations. A series of pilot reviews are being held to determine an effective pilot-machine interface. Pilots fly missions with nominal to 3-sigma dispersions in translational or rotational axes. Console dimensions, switch type and layout, hand controllers, and graphic interfaces are evaluated by the pilots and the GCC simulator is modified for subsequent runs. Initial results indicate a pilot preference for analog versus digital displays and for two 3-degree-of-freedom hand controllers.

  18. STS-78 Mission Insignia (United States)


    The STS-78 patch links past with present to tell the story of its mission and science through a design imbued with the strength and vitality of the 2-dimensional art of North America's northwest coast Indians. Central to the design is the space Shuttle whose bold lines and curves evoke the Indian image for the eagle, a native American symbol of power and prestige as well as the national symbol of the United States. The wings of the Shuttle suggest the wings of the eagle whose feathers, indicative of peace and friendship in Indian tradition, are captured by the U forms, a characteristic feature of Northwest coast Indian art. The nose of the Shuttle is the strong downward curve of the eagle's beak, and the Shuttle's forward windows, the eagle's eyes, represented through the tapered S forms again typical of this Indian art form. The basic black and red atoms orbiting the mission number recall the original NASA emblem while beneath, utilizing Indian ovoid forms, the major mission scientific experiment package LMS (Life and Materials Sciences) housed in the Shuttle's cargo bay is depicted in a manner reminiscent of totem-pole art. This image of a bird poised for flight, so common to Indian art, is counterpointed by an equally familiar Tsimshian Indian symbol, a pulsating sun with long hyperbolic rays, the symbol of life. Within each of these rays are now encased crystals, the products of this mission's 3 major, high-temperature materials processing furnaces. And as the sky in Indian lore is a lovely open country, home of the Sun Chief and accessible to travelers through a hole in the western horizon, so too, space is a vast and beckoning landscape for explorers launched beyond the horizon. Beneath the Tsimshian sun, the colors of the earth limb are appropriately enclosed by a red border representing life to the Northwest coast Indians. The Indian colors of red, navy blue, white, and black pervade the STS-78 path. To the right of the Shuttle-eagle, the constellation


    Dauro, V. A.


    IMP is a simulation language that is used to model missions around the Earth, Moon, Mars, or other planets. It has been used to model missions for the Saturn Program, Apollo Program, Space Transportation System, Space Exploration Initiative, and Space Station Freedom. IMP allows a user to control the mission being simulated through a large event/maneuver menu. Up to three spacecraft may be used: a main, a target and an observer. The simulation may begin at liftoff, suborbital, or orbital. IMP incorporates a Fehlberg seventh order, thirteen evaluation Runge-Kutta integrator with error and step-size control to numerically integrate the equations of motion. The user may choose oblate or spherical gravity for the central body (Earth, Mars, Moon or other) while a spherical model is used for the gravity of an additional perturbing body. Sun gravity and pressure and Moon gravity effects are user-selectable. Earth/Mars atmospheric effects can be included. The optimum thrust guidance parameters are calculated automatically. Events/maneuvers may involve many velocity changes, and these velocity changes may be impulsive or of finite duration. Aerobraking to orbit is also an option. Other simulation options include line-of-sight communication guidelines, a choice of propulsion systems, a soft landing on the Earth or Mars, and rendezvous with a target vehicle. The input/output is in metric units, with the exception of thrust and weight which are in English units. Input is read from the user's input file to minimize real-time keyboard input. Output includes vehicle state, orbital and guide parameters, event and total velocity changes, and propellant usage. The main output is to the user defined print file, but during execution, part of the input/output is also displayed on the screen. An included FORTRAN program, TEKPLOT, will display plots on the VDT as well as generating a graphic file suitable for output on most laser printers. The code is double precision. IMP is written in

  20. Safety, efficacy and pharmacokinetics of rVIII-SingleChain in children with severe hemophilia A: results of a multicenter clinical trial. (United States)

    Stasyshyn, O; Djambas Khayat, C; Iosava, G; Ong, J; Abdul Karim, F; Fischer, K; Veldman, A; Blackman, N; St Ledger, K; Pabinger, I


    Essentials rVIII-SingleChain is a novel recombinant factor VIII with covalently bonded heavy and light chains. Efficacy, safety and pharmacokinetics were studied in pediatric patients with severe hemophilia A. Across all prophylaxis regimens, the median annualized spontaneous bleeding rate was 0.00. rVIII-SingleChain showed excellent hemostatic efficacy and a favorable safety profile. Background rVIII-SingleChain is a novel B-domain truncated recombinant factor VIII (rFVIII) comprised of covalently bonded FVIII heavy and light chains, demonstrating a high binding affinity to von Willebrand factor. Objectives This phase III study investigated the safety, efficacy and pharmacokinetics of rVIII-SingleChain in previously treated pediatric patients hemophilia A. Patients/Methods Patients could be assigned to prophylaxis or on-demand therapy by the investigator. For patients assigned to prophylaxis, the treatment regimen and dose were based on the bleeding phenotype. For patients receiving on-demand therapy, dosing was guided by World Federation of Hemophilia recommendations. The primary endpoint was treatment success, defined as a rating of 'excellent' or 'good' on the investigator's clinical assessment of hemostatic efficacy for all treated bleeding events. Results The study enrolled 84 patients (0 to 50 EDs. In the 347 bleeds treated and evaluated by the investigator, hemostatic efficacy was rated as excellent or good in 96.3%. The median annualized spontaneous bleeding rate was 0.00 (Q1, Q3: 0.00, 2.20), and the median annualized bleeding rate was 3.69 (Q1, Q3: 0.00, 7.20) across all prophylaxis regimens. No participant developed an inhibitor. Conclusions rVIII-SingleChain is a novel rFVIII molecule showing excellent hemostatic efficacy and a favorable safety profile in a clinical study in children hemophilia A. © 2017 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and

  1. Severe Hemophilia A in a Male Old English Sheep Dog with a C→T Transition that Created a Premature Stop Codon in Factor VIII (United States)

    Lozier, Jay N; Kloos, Mark T; Merricks, Elizabeth P; Lemoine, Nathaly; Whitford, Margaret H; Raymer, Robin A; Bellinger, Dwight A; Nichols, Timothy C


    Animals with hemophilia are models for gene therapy, factor replacement, and inhibitor development in humans. We have actively sought dogs with severe hemophilia A that have novel factor VIII mutations unlike the previously described factor VIII intron 22 inversion. A male Old English Sheepdog with recurrent soft-tissue hemorrhage and hemarthrosis was diagnosed with severe hemophilia A (factor VIII activity less than 1% of normal). We purified genomic DNA from this dog and ruled out the common intron 22 inversion; we then sequenced all 26 exons. Comparing the results with the normal canine factor VIII sequence revealed a C→T transition in exon 12 of the factor VIII gene that created a premature stop codon at amino acid 577 in the A2 domain of the protein. In addition, 2 previously described polymorphisms that do not cause hemophilia were present at amino acids 909 and 1184. The hemophilia mutation creates a new TaqI site that facilitates rapid genotyping of affected offspring by PCR and restriction endonuclease analyses. This mutation is analogous to the previously described human factor VIII mutation at Arg583, which likewise is a CpG dinucleotide transition causing a premature stop codon in exon 12. Thus far, despite extensive treatment with factor VIII, this dog has not developed neutralizing antibodies (‘inhibitors’) to the protein. This novel mutation in a dog gives rise to severe hemophilia A analogous to a mutation seen in humans. This model will be useful for studies of the treatment of hemophilia. PMID:27780008

  2. The Waste Negotiator's mission

    International Nuclear Information System (INIS)

    Bataille, Christian


    The mission of the Waste Negotiator is to seek out sites for deep underground laboratories to study their potential for disposal of high level radioactive waste. Although appointed by the government, he acts independently. In 1990, faced by severe public criticism at the way that the waste disposal was being handled, and under increasing pressure to find an acceptable solution, the government stopped the work being carried out by ANDRA (Agence nationale pour la gestion des dechets radioactifs) and initiated a full review of the issues involved. At the same time, parliament also started its own extensive investigation to find a way forward. These efforts finally led to the provision of a detailed framework for the management of long lived radioactive waste, including the construction of two laboratories to investigate possible repository sites. The Waste Negotiator was appointed to carry out a full consultative process in the communities which are considering accepting an underground laboratory. (Author)

  3. STS-40 Mission Insignia (United States)


    The STS-40 patch makes a contemporary statement focusing on human beings living and working in space. Against a background of the universe, seven silver stars, interspersed about the orbital path of Columbia, represent the seven crew members. The orbiter's flight path forms a double-helix, designed to represent the DNA molecule common to all living creatures. In the words of a crew spokesman, ...(the helix) affirms the ceaseless expansion of human life and American involvement in space while simultaneously emphasizing the medical and biological studies to which this flight is dedicated. Above Columbia, the phrase Spacelab Life Sciences 1 defines both the Shuttle mission and its payload. Leonardo Da Vinci's Vitruvian man, silhouetted against the blue darkness of the heavens, is in the upper center portion of the patch. With one foot on Earth and arms extended to touch Shuttle's orbit, the crew feels, he serves as a powerful embodiment of the extension of human inquiry from the boundaries of Earth to the limitless laboratory of space. Sturdily poised amid the stars, he serves to link scentists on Earth to the scientists in space asserting the harmony of efforts which produce meaningful scientific spaceflight missions. A brilliant red and yellow Earth limb (center) links Earth to space as it radiates from a native American symbol for the sun. At the frontier of space, the traditional symbol for the sun vividly links America's past to America's future, the crew states. Beneath the orbiting Shuttle, darkness of night rests peacefully over the United States. Drawn by artist Sean Collins, the STS 40 Space Shuttle patch was designed by the crewmembers for the flight.

  4. NASA CYGNSS Mission Overview (United States)

    Ruf, C. S.; Balasubramaniam, R.; Gleason, S.; McKague, D. S.; O'Brien, A.


    The CYGNSS constellation of eight satellites was successfully launched on 15 December 2016 into a low inclination (tropical) Earth orbit. Each satellite carries a four-channel bi-static radar receiver that measures GPS signals scattered by the ocean, from which ocean surface roughness, near surface wind speed, and air-sea latent heat flux are estimated. The measurements are unique in several respects, most notably in their ability to penetrate through all levels of precipitation, made possible by the low frequency at which GPS operates, and in the frequent sampling of tropical cyclone intensification and of the diurnal cycle of winds, made possible by the large number of satellites. Engineering commissioning of the constellation was successfully completed in March 2017 and the mission is currently in the early phase of science operations. Level 2 science data products have been developed for near surface (10 m referenced) ocean wind speed, ocean surface roughness (mean square slope) and latent heat flux. Level 3 gridded versions of the L2 products have also been developed. A set of Level 4 products have also been developed specifically for direct tropical cyclone overpasses. These include the storm intensity (peak sustained winds) and size (radius of maximum winds), its extent (34, 50 and 64 knot wind radii), and its integrated kinetic energy. Assimilation of CYGNSS L2 wind speed data into the HWRF hurricane weather prediction model has also been developed. An overview and the current status of the mission will be presented, together with highlights of early on-orbit performance and scientific results.

  5. Rancang Bangun Perangkat Eksperimen Hukum Archimedes untuk MTs LB/A Yaketunis Kelas VIII

    Directory of Open Access Journals (Sweden)

    Rofiqoh Utami


    Full Text Available Blind students find difficulties whenever they are involved in the experiment of Archimedes principle as it requests an active visual role. Thus, it is very important to design a special tool for blind students so their practice of Archimedes principle become easier. This paper discusses a research finding which is an innovation of adaptive tools for blind students, such as beaker glass with Braille number, dynamometer with modification and Braille number (Braille Spring Balance and recording lesson about Archimedes principle. This research done for students MTs LB / A Yaketunis Class VIII which aims at analyzing the quality of each tool by media experts, lesson experts, and physics teacher of MTs LB/A.This research is R & D with procedural models adapted from the development of the 4-D models, namely Define, Design, Develop, and Disseminate. According to media expert assessment, beaker glass with Braille number and Braille spring balance has a very good quality with percentage of their respective 100% of the ideal score, while the assessment by lesson experts for each tool have a good quality with percentage 80% and 73.33% of the ideal score, and physics teacher of MTs LB / A assessment for each tool have a very good quality with percentage 100%. According to the media and lesson experts, the recording lesson about Archimedes principle have a good quality with percentage 80% of the ideal score, according to physics teacher MTs LB / A, the recording tool has excellent quality either with percentage 91.82% of the ideal score. This research recommends the blinds students to utilize these innovative-adaptive tools which will enable them appropriately practice Archimedes principle as non-blind students.

  6. Nonneutralizing antibodies against factor VIII and risk of inhibitor development in severe hemophilia A. (United States)

    Cannavò, Antonino; Valsecchi, Carla; Garagiola, Isabella; Palla, Roberta; Mannucci, Pier Mannuccio; Rosendaal, Frits R; Peyvandi, Flora


    The development of anti-factor VIII (FVIII) neutralizing antibodies (inhibitors) is the major complication in hemophilia A. Nonneutralizing antibodies (NNAs) have been detected in hemophilia patients and also in unaffected individuals. The aim of this study was to assess the prevalence of NNAs and to evaluate whether their presence is associated with the development of inhibitors in a cohort of previously untreated or minimally treated patients with hemophilia A; plasma samples of 237 patients with severe hemophilia A enrolled in the SIPPET trial were collected before any exposure to FVIII concentrates and analyzed for the presence of anti-FVIII NNAs. Patients were observed for the development of neutralizing antibodies. NNAs were found in 18 (7.6%) of 237 patients at screening, and there was a clear age gradient. Of those with NNAs, 7 patients subsequently developed an inhibitor for a cumulative incidence of 45.4% (95% confidence interval [CI], 19.5% to 71.3%); among the 219 patients without NNAs, 64 (29%) developed an inhibitor (cumulative incidence, 34.0%; 95% CI, 27.1%-40.9%). In Cox regression analyses, patients with NNAs at screening had an 83% higher incidence of inhibitor development than patients without NNAs (hazard ratio [HR], 1.83; 95% CI, 0.84-3.99). For high-titer inhibitors, the incidence rate had an almost threefold increase (HR, 2.74; 95% CI, 1.23-6.12). These associations did not materially change after adjustment. The presence of anti-FVIII NNAs in patients with severe hemophilia A who were not previously exposed to FVIII concentrates is associated with an increased incidence of inhibitors. © 2017 by The American Society of Hematology.

  7. Frequencies of VNTR and RFLP polymorphisms associated with factor VIII gene in Singapore

    Energy Technology Data Exchange (ETDEWEB)

    Fong, I.; Lai, P.S.; Ouah, T.C. [National Univ. of Singapore (Malaysia)] [and others


    The allelic frequency of any polymorphism within a population determines its usefulness for genetic counselling. This is important in populations of non-Caucasian origin as RFLPs may significantly differ among ethnic groups. We report a study of five intragenic polymorphisms in factor VIII gene carried out in Singapore. The three PCR-based RFLP markers studied were Intron 18/Bcl I, Intron 19/Hind III and Intron 22/Xba I. In an analysis of 148 unrelated normal X chromosomes, the allele frequencies were found to be A1 = 0.18, A2 = 0.82 (Bcl I RFLP), A1 = 0.80, A2 = 0.20 (Hind III RFLP) and A1 = 0.58, and A2 = 0.42 (Xba I RFLP). The heterozygosity rates of 74 females analyzed separately were 31%, 32% and 84.2%, respectively. Linkage disequilibrium was also observed to some degree between Bcl I and Hind III polymorphism in our population. We have also analyzed a sequence polymorphism in Intron 7 using hybridization with radioactive-labelled {sup 32}P allele-specific oligonucleotide probes. This polymorphism was not very polymorphic in our population with only 2% of 117 individuals analyzed being informative. However, the use of a hypervariable dinucleotide repeat sequence (VNTR) in Intron 13 showed that 25 of our of 27 (93%) females were heterozygous. Allele frequencies ranged from 1 to 55 %. We conclude that a viable strategy for molecular analysis of Hemophilia A families in our population should include the use of Intron 18/Bcl I and Intron 22/Xba I RFLP markers and the Intron 13 VNTR marker.

  8. The Messenger Mission to Mercury

    CERN Document Server

    Domingue, D. L


    NASA’s MESSENGER mission, launched on 3 August, 2004 is the seventh mission in the Discovery series. MESSENGER encounters the planet Mercury four times, culminating with an insertion into orbit on 18 March 2011. It carries a comprehensive package of geophysical, geological, geochemical, and space environment experiments to complete the complex investigations of this solar-system end member, which begun with Mariner 10. The articles in this book, written by the experts in each area of the MESSENGER mission, describe the mission, spacecraft, scientific objectives, and payload. The book is of interest to all potential users of the data returned by the MESSENGER mission, to those studying the nature of the planet Mercury, and by all those interested in the design and implementation of planetary exploration missions.

  9. Valor preditivo da expressão dos anticorpos Antifator VIII no carcinoma epidermóide do esôfago Predictive value of antifactor VIII antibody expression in squamous cell carcinoma of the esophagus

    Directory of Open Access Journals (Sweden)

    Sebastião Gonzaga Barbosa-Neto


    Full Text Available RACIONAL: O carcinoma epidermóide do esôfago apresenta alta mortalidade, baixo índice de diagnóstico precoce e altos custos nos tratamentos, com resultados freqüentemente desapontadores e prognóstico sombrio. O melhor entendimento das técnicas de biologia molecular com citofotometria de imagem, permitiu avançar no conhecimento das alterações na expressão das proteínas desse câncer. OBJETIVOS: Quantificar a expressão das proteínas envolvidas na angiogênese e correlacioná-las com variáveis clínico-patológicas. MÉTODOS: Com o uso da técnica de imunoistoquímica, citofotometria de imagem pelo sistema SAMBA, foram analisadas 29 amostras de carcinoma epidermóide do esôfago incluídas em blocos de parafina. Critérios clínicos como idade, sexo e histopatológicos do grau de diferenciação tumoral, tamanho e localização do tumor foram analisados. Os parâmetros analisados foram o índice de marcagem e a densidade óptica. O marcador utilizado foi o anticorpo anti-Fator VIII. RESULTADOS: Foi possível verificar que as expressões médias do marcador no índice de marcagem foram maiores que as da densidade óptica. Fator VIII apresentou leituras homogêneas. O índice de marcagem foi de 80,17+/-10,40 com P=0,073 e a densidade óptica 51,25+/-11,02 com P=0,245. CONCLUSÃO: A análise quantificação da expressão das proteínas envolvidas na angiogênese permite definir subgrupos de acordo com a diferenciação do carcinoma, estágio tumoral, tamanho e localização do tumor, porém não associa-se com o sexo e a idade dos pacientes, e a densidade óptica do Fator VIII não tem expressão significativa em nenhum dos subgrupos analisados.BACKGROUND: Squamous cell carcinoma of the esophagus exhibits high mortality rate, rare precocious diagnosis, and expensive treatments, presenting frequently disappointed results and poor prognosis. The better understanding about Molecular Biology techniques using cytophotometric imaging allowed

  10. Lunar Exploration Missions Since 2006 (United States)

    Lawrence, S. J. (Editor); Gaddis, L. R.; Joy, K. H.; Petro, N. E.


    The announcement of the Vision for Space Exploration in 2004 sparked a resurgence in lunar missions worldwide. Since the publication of the first "New Views of the Moon" volume, as of 2017 there have been 11 science-focused missions to the Moon. Each of these missions explored different aspects of the Moon's geology, environment, and resource potential. The results from this flotilla of missions have revolutionized lunar science, and resulted in a profoundly new emerging understanding of the Moon. The New Views of the Moon II initiative itself, which is designed to engage the large and vibrant lunar science community to integrate the results of these missions into new consensus viewpoints, is a direct outcome of this impressive array of missions. The "Lunar Exploration Missions Since 2006" chapter will "set the stage" for the rest of the volume, introducing the planetary community at large to the diverse array of missions that have explored the Moon in the last decade. Content: This chapter will encompass the following missions: Kaguya; ARTEMIS (Acceleration, Reconnection, Turbulence, and Electrodynamics of the Moon’s Interaction with the Sun); Chang’e-1; Chandrayaan-1; Moon Impact Probe; Lunar Reconnaissance Orbiter (LRO); Lunar Crater Observation Sensing Satellite (LCROSS); Chang’e-2; Gravity Recovery and Interior Laboratory (GRAIL); Lunar Atmosphere and Dust Environment Explorer (LADEE); Chang’e-3.

  11. IRIS Mission Operations Director's Colloquium (United States)

    Carvalho, Robert; Mazmanian, Edward A.


    Pursuing the Mysteries of the Sun: The Interface Region Imaging Spectrograph (IRIS) Mission. Flight controllers from the IRIS mission will present their individual experiences on IRIS from development through the first year of flight. This will begin with a discussion of the unique nature of IRISs mission and science, and how it fits into NASA's fleet of solar observatories. Next will be a discussion of the critical roles Ames contributed in the mission including spacecraft and flight software development, ground system development, and training for launch. This will be followed by experiences from launch, early operations, ongoing operations, and unusual operations experiences. The presentation will close with IRIS science imagery and questions.

  12. Detection of small-size planetary candidates with CoRoT data

    Directory of Open Access Journals (Sweden)

    Moutou C.


    Full Text Available With the discovery of CoRoT-7b, the first transiting super-Earth, the CoRoT space mission has shown the capability to detect short-period rocky planets around solar-like stars. By performing a blind test with real CoRoT light curves, we want to establish the detection threshold of small-size planets in CoRoT data. We investigate the main obstacles to the detection of transiting super-Earths in CoRoT data, notably the presence of short-time scale variability and hot pixels.

  13. Bomber Deterrence Missions: Criteria To Evaluate Mission Effectiveness (United States)


    international security, the practice of general deterrence usually occurs when nations feel insecure , suspicious or even hostility towards them but...both a deterrence and assurance mission even though it was not planned or advertised as such. Since the intent of this mission was partly perceived


    Directory of Open Access Journals (Sweden)

    Mutthofiyah Mutthofiyah


    Full Text Available Penelitian ini bertujuan untukmeningkatkan aktivitas belajar siswa dengan menggunakan metode group investigation (GI pada pokok bahasan pasar pada penelitian ini menggunakan penelitian tindakan kelas (PTK. Dalam penelitian ini dirancang menggunakan siklus, masing-masing siklus dengan tahapan perencanaan, pelaksanaan tindakan, observasi dan refleksi. Teknik pengumpulan data pada penelitian ini adalah dokumentasi, observasi dan tes.Hasil penelitian menunjukkan melalui meningkatkan metode group investigation (GI aktivitas siswa SMP 5 Kudus ada peningkatan yang sigifikan, dari siklus I kelas VIII F 15,8 (41,62% meningkat di siklus II menjadi 24,8 (72,9%, sedangkan di kelas VIII G siklus I 18,5 (47,04% meningkat menjadi 26,2 (74,7%; melalui penerapan metode group investigation hasil belajar siswa SMP 5 kudus meningkat sangat signifkan, ketuntasan belajar secara klasikal dari kelas VIII F pra siklus sebesar 17,64% terjadi peningkatan 47% ke siklus I dan meningkat menjadi 82,35% di siklus II. Sedangkan di kelas VII G pra siklus sebesar 22,85% meningkat 54,28% di siklus I dan meningkat menjadi 94,28% di siklus II. Saran yang peneliti berikan adalah sebagai berikut:1Kepada para guru diharapkan dapat menerapkan pembelajaran kooperatif khususnya pembelajaran kooperatif tipe Group Investigation (GI dalam proses pembelajaran ekonomi dan mata pelajaran lainya dan mengembangkannya; 2 Kepada para peneliti selanjutnya diharapkan dapat melakukan penelitian tentang penerapan model pembelajaran yang dapat membangkitkan keaktifan siswa untuk belajar ekonomi. This study aims to improve students' learning activities using group investigation (GI on the subject of markets in class VIII SMP 5 Kudus. In this study is designed to use cycles, with each cycle stages of planning, action, observation and reflection. Data collection techniques in this study is documentation, observation and tests. Results showed through improved methods of group investigation (GI junior 5 high

  15. Simulation of Mission Phases (United States)

    Carlstrom, Nicholas Mercury


    This position with the Simulation and Graphics Branch (ER7) at Johnson Space Center (JSC) provided an introduction to vehicle hardware, mission planning, and simulation design. ER7 supports engineering analysis and flight crew training by providing high-fidelity, real-time graphical simulations in the Systems Engineering Simulator (SES) lab. The primary project assigned by NASA mentor and SES lab manager, Meghan Daley, was to develop a graphical simulation of the rendezvous, proximity operations, and docking (RPOD) phases of flight. The simulation is to include a generic crew/cargo transportation vehicle and a target object in low-Earth orbit (LEO). Various capsule, winged, and lifting body vehicles as well as historical RPOD methods were evaluated during the project analysis phase. JSC core mission to support the International Space Station (ISS), Commercial Crew Program (CCP), and Human Space Flight (HSF) influenced the project specifications. The simulation is characterized as a 30 meter +V Bar and/or -R Bar approach to the target object's docking station. The ISS was selected as the target object and the international Low Impact Docking System (iLIDS) was selected as the docking mechanism. The location of the target object's docking station corresponds with the RPOD methods identified. The simulation design focuses on Guidance, Navigation, and Control (GNC) system architecture models with station keeping and telemetry data processing capabilities. The optical and inertial sensors, reaction control system thrusters, and the docking mechanism selected were based on CCP vehicle manufacturer's current and proposed technologies. A significant amount of independent study and tutorial completion was required for this project. Multiple primary source materials were accessed using the NASA Technical Report Server (NTRS) and reference textbooks were borrowed from the JSC Main Library and International Space Station Library. The Trick Simulation Environment and User

  16. Business analysis: The commercial mission of the International Asteroid Mission (United States)

    The mission of the International Asteroid Mission (IAM) is providing asteroidal resources to support activities in space. The short term goal is to initiate IAM by mining a near-Earth, hydrous carbonaceous chondrite asteroid to service the nearer-term market of providing cryogenic rocket fuel in low lunar orbit (LLO). The IAM will develop and contract for the building of the transportation vehicles and equipment necessary for this undertaking. The long-term goal is to expand operations by exploiting asteroids in other manners, as these options become commercially viable. The primary business issues are what revenue can be generated from the baseline mission, how much will the mission cost, and how funding for this mission can be raised. These issues are addressed.

  17. The Impact of Mission Duration on a Mars Orbital Mission (United States)

    Arney, Dale; Earle, Kevin; Cirillo, Bill; Jones, Christopher; Klovstad, Jordan; Grande, Melanie; Stromgren, Chel


    Performance alone is insufficient to assess the total impact of changing mission parameters on a space mission concept, architecture, or campaign; the benefit, cost, and risk must also be understood. This paper examines the impact to benefit, cost, and risk of changing the total mission duration of a human Mars orbital mission. The changes in the sizing of the crew habitat, including consumables and spares, was assessed as a function of duration, including trades of different life support strategies; this was used to assess the impact on transportation system requirements. The impact to benefit is minimal, while the impact on cost is dominated by the increases in transportation costs to achieve shorter total durations. The risk is expected to be reduced by decreasing total mission duration; however, large uncertainty exists around the magnitude of that reduction.

  18. Hipparcos: mission accomplished (United States)


    During the last few months of its life, as the high radiation environment to which the satellite was exposed took its toll on the on-board system, Hipparcos was operated with only two of the three gyroscopes normally required for such a satellite, following an ambitious redesign of the on-board and on-ground systems. Plans were in hand to operate the satellite without gyroscopes at all, and the first such "gyro- less" data had been acquired, when communication failure with the on-board computers on 24 June 1993 put an end to the relentless flow of 24000 bits of data that have been sent down from the satellite each second, since launch. Further attempts to continue operations proved unsuccessful, and after a short series of sub-systems tests, operations were terminated four years and a week after launch. An enormous wealth of scientific data was gathered by Hipparcos. Even though data analysis by the scientific teams involved in the programme is not yet completed, it is clear that the mission has been an overwhelming success. "The ESA advisory bodies took a calculated risk in selecting this complex but fundamental programme" said Dr. Roger Bonnet, ESA's Director of Science, "and we are delighted to have been able to bring it to a highly successful conclusion, and to have contributed unique information that will take a prominent place in the history and development of astrophysics". Extremely accurate positions of more than one hundred thousand stars, precise distance measurements (in most cases for the first time), and accurate determinations of the stars' velocity through space have been derived. The resulting HIPPARCOS Star Catalogue, expected to be completed in 1996, will be of unprecedented accuracy, achieving results some 10-100 times more accurate than those routinely determined from ground-based astronomical observatories. A further star catalogue, the Thyco Star Catalogue of more than a million stars, is being compiled from additional data accumulated by the

  19. Staining for factor VIII related antigen and Ulex europaeus agglutinin I (UEA-I) in 230 tumours. An assessment of their specificity for angiosarcoma and Kaposi's sarcoma. (United States)

    Leader, M; Collins, M; Patel, J; Henry, K


    In this study we examined the staining reactivity of commercially available antisera to factor VIII related antigen (F VIII RAg) and Ulex europaeus agglutinin I (UEA-I) on sections from 230 formalin fixed paraffin embedded tumours. These included 196 sarcomas, 20 carcinomas and 14 angiomas. All angiomas showed positive staining for F VIII RAg; all carcinomas showed negative staining; the vasoformative areas of all angiosarcomas stained positively but only four of six angiosarcomas showed positive staining of their solid areas; of seven Kaposi's sarcomas, all showed positive staining of vessels and six showed positive staining of the spindle cell component. In the remaining 181 non-vascular sarcomas there was a false positive result in four tumours (2.2%), three of which had a history of irradiation. Pre-radiotherapy biopsies of these three tumours stained negatively with anti-F VIII RAg. UEA-I was demonstrated in all the angiomas studied, in all angiosarcomas (including the solid components) and in well-formed vessels of all Kaposi's sarcomas, but only in the spindle cell component of 3/6. However, there was an unacceptably high rate of false positive staining amongst the carcinomas and non-vascular sarcomas. In conclusion, F VIII RAg is a specific but not a sensitive marker of angiosarcomas; UEA-I is a sensitive but not a specific marker of angiosarcomas.

  20. The Effect of Growth Temperature and V/III Flux Ratio of MOCVD Antimony Based Semiconductors on Growth Rate and Surface Morphology

    Directory of Open Access Journals (Sweden)

    Ramelan Ari Handono


    Full Text Available Epitaxial Alx Ga1-x Sb layers on GaSb and GaAs substrates have been grown by atmospheric pressure metalorganic chemical vapor deposition using TMAl, TMGa and TMSb. Nomarski microscope and a profiler were employed to examine the surface morphology and growth rate of the samples. We report the effect of growth temperature and V/III flux ratio on growth rate and surface morphology. Growth temperatures in the range of 520°C and 680°C and V/III ratios from 1 to 5 have been investigated. A growth rate activation energy of 0.73 eV was found. At low growth temperatures between 520 and 540°C, the surface morphology is poor due to antimonide precipitates associated with incomplete decomposition of the TMSb. For layers grown on GaAs at 580°C and 600°C with a V/III ratio of 3 a high quality surface morphology is typical, with a mirror-like surface and good composition control. It was found that a suitable growth temperature and V/III flux ratio was beneficial for producing good AlGaSb layers. Undoped AlGaSb grown at 580°C with a V/III flux ratio of 3 at the rate of 3.5 μm/hour shows p-type conductivity with smooth surface morphology


    Directory of Open Access Journals (Sweden)



    Full Text Available Abstract: Pessimism and attitudes that consider themselves weak and does not have the ability when facing a problem will make individual impediment in the task of development. Problems confidence that underlies the research are: a Students are less confident in the ability it has, b Students feel pessimistic when faced with an issue, c Student perception subjectively, d Students still do not do the work independently, and e negative minded students with a state-owned. The problems of this study are whether there is an influence of information services using the medium of film to the confidence of eighth-grade students of SMP Negeri 8 Metro. The purpose of this study was to determine whether there is an influence of information services using the medium of film to the self-confidence of students in class VIII SMP Negeri 8 Metro. Subject participant is graders VIII-E total 30 students. Data were collected by questionnaire self-confidence and analyzed the data used is the t-test. The results of this study, shown by the difference in change scores of confidence from the pre-test and post-test of 17.1. Testing the hypothesis obtained calculation results thitung6,036> table = 1.699. The conclusion is that the information services implemented using the film medium can be a positive influence on self-esteem, especially students of class VIII. The advice given is to use the medium of film should be done intensively and more creative by BK teachers in giving information service. Keywords: Confidence, Service Information Using Media Film.

  2. Seleucid, Demotic and Mediterranean mathematics versus Chapters VIII and IX of the Nine Chapters: accidental or significant similarities?

    DEFF Research Database (Denmark)

    Høyrup, Jens

    Similarities of geometrical diagrams and arithmetical structures of problems have often been taken as evidence of transmission of mathematical knowledge or techniques between China and “the West”. Confronting on one hand some problems from Chapter VIII of the Nine Chapters with comparable problems...... known from Ancient Greek sources, on the other a Seleucid collection of problems about rectangles with a subset of the triangle problems from Chapter IX, it is concluded, (1) that transmission of some arithmetical riddles without method – not “from Greece” but from a transnational community of traders...

  3. [The beneficial effect of mineral waters of Fiuggi on Pope Bonifacio VIII and Michelangelo: two prominent calculous patients]. (United States)

    Androutsos, Georges


    Going back to the dawn of time, we deal with two historical figures, that of Pope Bonifacio VIII, and that of the hierophant of art, Michelangelo Buonarroti. The texts and the codes of the British Museum (Department of Manuscripts), of the Biblioteca Medica Laurenziana (Archivio Buonarroti) of Florence, and the Biblioteca Apostolica of Vatican, convincing detalled evidence that both figures were urological patients. It concerns two clinical cases with especially pertain to the history of lithiasis of urinary tract. Even though, both of them--the first with nephrolithiasis or gravel, and the second with a bladder stone--were historically bound with the well-known cures of Fiuggi in Italy.

  4. Evaluation of the integrity of reactor vessels designed to ASME Code, Sections I and/or VIII

    International Nuclear Information System (INIS)

    Hoge, K.G.


    A documented review of nuclear reactor pressure vessels designed to ASME Code, Sections I and/or VIII is made. The review is primarily concerned with the design specifications and quality assurance programs utilized for the reactor vessel construction and the status of power plant material surveillance programs, pressure-temperature operating limits, and inservice inspection programs. The following ten reactor vessels for light-water power reactors are covered in the report: Indian Point Unit No. 1, Dresden Unit No. 1, Yankee Rowe, Humboldt Bay Unit No. 3, Big Rock Point, San Onofre Unit No. 1, Connecticut Yankee, Oyster Creek, Nine Mile Point Unit No. 1, and La Crosse

  5. EK(b)P Keskkomitee VIII pleenumi stenogramm / tõlk. Mart Arold, tõlk. Jaan Isotamm

    Index Scriptorium Estoniae


    EK(b)P Keskkomitee VIII pleenum, 21.-23. märts 1950. Sõnavõtud: N. Karotamm, P. Ponomarenko, I. Käbin, V. Kuusik, A. Jaanus, V. Hiznjakov, E. Ristimägi, I. Suija, H. Ajo, A. Meri, G. Abels, M. Assin, G. Latõshov, Rumjantsev, Müürisepp. Kommenteerinud Viktor Niitsoo. Algus: Akadeemia (1998) nr. 12, lk. 2655-2683 ; Järg nr.2;3;4;5;6;7;8;9;10 lk.415-446;639-670;863-894;1087-1118;1310-1342;1534-1566;1759-1790;2017-2048;2220-2256

  6. Love and/in psychoanalysis: a commentary on Lacan's reading of Plato's Symposium in Seminar VIII: Transference. (United States)

    Fink, Bruce


    What is love and what part does it play in psychoanalysis? Where are the analyst and the analysand situated in relation to the roles defined as those of the "lover" and the "beloved"? Jacques Lacan explores these and other questions in his soon-to-be-published Seminar VIII: Transference by providing an extensive commentary on Plato's most famous dialogue on love, the Symposium. This paper outlines some of the major points about love that grow out of Lacan's reading of the dialogue and examines their relevance to the analytic setting. Can the analyst be characterized as a sort of modern-day Socrates?

  7. Recombinant factor VIII Fc fusion protein for the prevention and treatment of bleeding in children with severe hemophilia A. (United States)

    Young, G; Mahlangu, J; Kulkarni, R; Nolan, B; Liesner, R; Pasi, J; Barnes, C; Neelakantan, S; Gambino, G; Cristiano, L M; Pierce, G F; Allen, G


    Prophylactic factor replacement, which prevents hemarthroses and thereby reduces the musculoskeletal disease burden in children with hemophilia A, requires frequent intravenous infusions (three to four times weekly). Kids A-LONG was a phase 3 open-label study evaluating the safety, efficacy and pharmacokinetics of a longer-acting factor, recombinant factor VIII Fc fusion protein (rFVIIIFc), in previously treated children with severe hemophilia A (endogenous FVIII level of hemophilia A. © 2015 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.

  8. Human parvovirus B19 infection in hemophiliacs first infused with two high-purity, virally attenuated factor VIII concentrates. (United States)

    Azzi, A; Ciappi, S; Zakvrzewska, K; Morfini, M; Mariani, G; Mannucci, P M


    Human parvovirus B19 can be transmitted by coagulation factor concentrates and is highly resistant to virucidal methods. To evaluate whether the additional removal of virus by chromatographic methods during the manufacture of high-purity concentrates reduces the risk of B19 transmission, we have prospectively evaluated the rate of anti-B19 seroconversion in two groups of susceptible (anti-B19 negative) hemophiliacs infused with high-purity, heated (pasteurized) or solvent-detergent-treated factor VIII concentrates. Both products infected a relatively high proportion of patients (nine of 20).

  9. The AGILE Mission

    CERN Document Server

    Tavani, M.; Argan, A.; Boffelli, F.; Bulgarelli, A.; Caraveo, P.; Cattaneo, P.W.; Chen, A.W.; Cocco, V.; Costa, E.; D'Ammando, F.; Del Monte, E.; De Paris, G.; Di Cocco, G.; Di Persio, G.; Donnarumma, I.; Evangelista, Y.; Feroci, M.; Ferrari, A.; Fiorini, M.; Fornari, F.; Fuschino, F.; Froysland, T.; Frutti, M.; Galli, M.; Gianotti, F.; Giuliani, A.; Labanti, C.; Lapshov, I.; Lazzarotto, F.; Liello, F.; Lipari, P.; Longo, F.; Mattaini, E.; Marisaldi, M.; Mastropietro, M.; Mauri, A.; Mauri, F.; Mereghetti, S.; Morelli, E.; Morselli, A.; Pacciani, L.; Pellizzoni, A.; Perotti, F.; Piano, G.; Picozza, P.; Pontoni, C.; Porrovecchio, G.; Prest, M.; Pucella, G.; Rapisarda, M.; Rappoldi, A.; Rossi, E.; Rubini, A.; Soffitta, P.; Traci, A.; Trifoglio, M.; Trois, A.; Vallazza, E.; Vercellone, S.; Vittorini, V.; Zambra, A.; Zanello, D.; Pittori, C.; Preger, B.; Santolamazza, P.; Verrecchia, F.; Giommi, P.; Colafrancesco, S.; Antonelli, A.; Cutini, S.; Gasparrini, D.; Stellato, S.; Fanari, G.; Primavera, R.; Tamburelli, F.; Viola, F.; Guarrera, G.; Salotti, L.; D'Amico, F.; Marchetti, E.; Crisconio, M.; Sabatini, P.; Annoni, G.; Alia, S.; Longoni, A.; Sanquerin, R.; Battilana, M.; Concari, P.; Dessimone, E.; Grossi, R.; Parise, A.; Monzani, F.; Artina, E.; Pavesi, R.; Marseguerra, G.; Nicolini, L.; Scandelli, L.; Soli, L.; Vettorello, V.; Zardetto, E.; Bonati, A.; Maltecca, L.; D'Alba, E.; Patane, M.; Babini, G.; Onorati, F.; Acquaroli, L.; Angelucci, M.; Morelli, B.; Agostara, C.; Cerone, M.; Michetti, A.; Tempesta, P.; D'Eramo, S.; Rocca, F.; Giannini, F.; Borghi, G.; Garavelli, B.; Conte, M.; Balasini, M.; Ferrario, I.; Vanotti, M.; Collavo, E.; Giacomazzo, M.


    AGILE is an Italian Space Agency mission dedicated to the observation of the gamma-ray Universe. The AGILE very innovative instrumentation combines for the first time a gamma-ray imager (sensitive in the energy range 30 MeV - 50 GeV), a hard X-ray imager (sensitive in the range 18-60 keV) together with a Calorimeter (sensitive in the range 300 keV - 100 MeV) and an anticoincidence system. AGILE was successfully launched on April 23, 2007 from the Indian base of Sriharikota and was inserted in an equatorial orbit with a very low particle background. AGILE provides crucial data for the study of Active Galactic Nuclei, Gamma-Ray Bursts, pulsars, unidentified gamma-ray sources, Galactic compact objects, supernova remnants, TeV sources, and fundamental physics by microsecond timing. An optimal angular resolution (reaching 0.1-0.2 degrees in gamma-rays, 1-2 arcminutes in hard X-rays) and very large fields of view (2.5 sr and 1 sr, respectively) are obtained by the use of Silicon detectors integrated in a very compa...

  10. STS-68 Mission Insignia (United States)


    This STS-68 patch was designed by artist Sean Collins. Exploration of Earth from space is the focus of the design of the insignia, the second flight of the Space Radar Laboratory (SRL-2). SRL-2 was part of NASA's Mission to Planet Earth (MTPE) project. The world's land masses and oceans dominate the center field, with the Space Shuttle Endeavour circling the globe. The SRL-2 letters span the width and breadth of planet Earth, symbolizing worldwide coverage of the two prime experiments of STS-68: The Shuttle Imaging Radar-C and X-Band Synthetic Aperture Radar (SIR-C/X-SAR) instruments; and the Measurement of Air Pollution from Satellites (MAPS) sensor. The red, blue, and black colors of the insignia represent the three operating wavelengths of SIR-C/X-SAR, and the gold band surrounding the globe symbolizes the atmospheric envelope examined by MAPS. The flags of international partners Germany and Italy are shown opposite Endeavour. The relationship of the Orbiter to Earth highlights the usefulness of human space flights in understanding Earth's environment, and the monitoring of its changing surface and atmosphere. In the words of the crew members, the soaring Orbiter also typifies the excellence of the NASA team in exploring our own world, using the tools which the Space Program developed to explore the other planets in the solar system.

  11. Draft Mission Plan Amendment

    Energy Technology Data Exchange (ETDEWEB)



    The Department of Energy`s Office Civilian Radioactive Waste Management has prepared this document to report plans for the Civilian Radioactive Waste Management Program, whose mission is to manage and dispose of the nation`s spent fuel and high-level radioactive waste in a manner that protects the health and safety of the public and of workers and the quality of the environment. The Congress established this program through the Nuclear Waste Policy Act of 1982. Specifically, the Congress directed us to isolate these wastes in geologic repositories constructed in suitable rock formations deep beneath the surface of the earth. In the Nuclear Waste Policy Amendments Act of 1987, the Congress mandated that only one repository was to be developed at present and that only the Yucca Mountain candidate site in Nevada was to be characterized at this time. The Amendments Act also authorized the construction of a facility for monitored retrievable storage (MRS) and established the Office of the Nuclear Waste Negotiator and the Nuclear Waste Technical Review Board. After a reassessment in 1989, the Secretary of Energy restructured the program, focusing the repository effort scientific evaluations of the Yucca Mountain candidate site, deciding to proceed with the development of an MRS facility, and strengthening the management of the program. 48 refs., 32 figs.

  12. NASA's interstellar probe mission

    International Nuclear Information System (INIS)

    Liewer, P.C.; Ayon, J.A.; Wallace, R.A.; Mewaldt, R.A.


    NASA's Interstellar Probe will be the first spacecraft designed to explore the nearby interstellar medium and its interaction with our solar system. As envisioned by NASA's Interstellar Probe Science and Technology Definition Team, the spacecraft will be propelled by a solar sail to reach >200 AU in 15 years. Interstellar Probe will investigate how the Sun interacts with its environment and will directly measure the properties and composition of the dust, neutrals and plasma of the local interstellar material which surrounds the solar system. In the mission concept developed in the spring of 1999, a 400-m diameter solar sail accelerates the spacecraft to ∼15 AU/year, roughly 5 times the speed of Voyager 1 and 2. The sail is used to first bring the spacecraft to ∼0.25 AU to increase the radiation pressure before heading out in the interstellar upwind direction. After jettisoning the sail at ∼5 AU, the spacecraft coasts to 200-400 AU, exploring the Kuiper Belt, the boundaries of the heliosphere, and the nearby interstellar medium

  13. Draft Mission Plan Amendment

    International Nuclear Information System (INIS)


    The Department of Energy's Office Civilian Radioactive Waste Management has prepared this document to report plans for the Civilian Radioactive Waste Management Program, whose mission is to manage and dispose of the nation's spent fuel and high-level radioactive waste in a manner that protects the health and safety of the public and of workers and the quality of the environment. The Congress established this program through the Nuclear Waste Policy Act of 1982. Specifically, the Congress directed us to isolate these wastes in geologic repositories constructed in suitable rock formations deep beneath the surface of the earth. In the Nuclear Waste Policy Amendments Act of 1987, the Congress mandated that only one repository was to be developed at present and that only the Yucca Mountain candidate site in Nevada was to be characterized at this time. The Amendments Act also authorized the construction of a facility for monitored retrievable storage (MRS) and established the Office of the Nuclear Waste Negotiator and the Nuclear Waste Technical Review Board. After a reassessment in 1989, the Secretary of Energy restructured the program, focusing the repository effort scientific evaluations of the Yucca Mountain candidate site, deciding to proceed with the development of an MRS facility, and strengthening the management of the program. 48 refs., 32 figs

  14. Liquid Effluents Program mission analysis

    International Nuclear Information System (INIS)

    Lowe, S.S.


    Systems engineering is being used to identify work to cleanup the Hanford Site. The systems engineering process transforms an identified mission need into a set of performance parameters and a preferred system configuration. Mission analysis is the first step in the process. Mission analysis supports early decision-making by clearly defining the program objectives, and evaluating the feasibility and risks associated with achieving those objectives. The results of the mission analysis provide a consistent basis for subsequent systems engineering work. A mission analysis was performed earlier for the overall Hanford Site. This work was continued by a ''capstone'' team which developed a top-level functional analysis. Continuing in a top-down manner, systems engineering is now being applied at the program and project levels. A mission analysis was conducted for the Liquid Effluents Program. The results are described herein. This report identifies the initial conditions and acceptable final conditions, defines the programmatic and physical interfaces and sources of constraints, estimates the resources to carry out the mission, and establishes measures of success. The mission analysis reflects current program planning for the Liquid Effluents Program as described in Liquid Effluents FY 1995 Multi-Year Program Plan

  15. STS-51J Mission Insignia (United States)


    The 51-J mission insignia, designed by Atlantis's first crew, pays tribute to the Statue of Liberty and the ideas it symbolizes. The historical gateway figure bears additional significance for Astronauts Karol J. Bobko, mission commander; and Ronald J. Grabe, pilot, both New Your Natives.

  16. GRACE Status at Mission End (United States)

    Tapley, B. D.; Flechtner, F. M.; Watkins, M. M.; Bettadpur, S. V.


    The twin satellites of the Gravity Recovery and Climate Experiment (GRACE) were launched on March 17, 2002 and have operated for nearly 16 years. The mission objectives are to observe the spatial and temporal variations of the Earth's mass through its effects on the gravity field at the GRACE satellite altitude. The mass changes observed are related to both the changes within the solid earth and the change within and between the Erath system components. A significant cause of the time varying mass is water motion and the GRACE mission has provided a continuous decade long measurement sequence which characterizes the seasonal cycle of mass transport between the oceans, land, cryosphere and atmosphere; its inter-annual variability; and the climate driven secular, or long period, mass transport signals. The fifth reanalysis on the mission data set, the RL05 data, were released in mid-2013. With the planned launch of GRACE Follow-On in early 2018, plans are underway for a reanalysis that will be consistent with the GRACE FO processing standards. The mission is entering the final phases of its operation life with mission end expected to occur in early 2018. The current mission operations strategy emphasizes extending the mission lifetime to obtain an overlap with the GRACE FO. This presentation will review the mission status and the projections for mission lifetime, describe the current operations philosophy and its impact on the science data, discuss the issues related to achieving the GRACE and GRACE FO connection and discuss issues related to science data products during this phase of the mission period.


    Directory of Open Access Journals (Sweden)

    Syahrida Zaerani


    Abstract: This study aims to determine the impact of the mastery of Pythagoras Theorem concepts on the ability of MTs Negeri Balang-Balang grade VIII students to solve polyhedron problems. This study is a quantitative research with ex post facto design. Statistical population consists of all grade VIII students in MTs Negeri Balang-Balang which was 204 students. The number of sampling used is 102 respondents taken by simple random sampling technique. The research instrument was a test related to Pythagorean an polyhedron problems. Descriptive and inferential statistics were performed as the statistical analysis. The descriptive analysis result shows that the mastery of Pythagoras Theorem concepts is within the category of ‘high’ and the ability of solving polyhedron problems is as well. The inferential statistical analysis using simple linear regression shows that there is an impact of the mastery of Pythagoras Theorem concepts on polyhedron problem solving ability of Grade VIII students of MTs Negeri Balang-Balang.

  18. The Magnetospheric Multiscale Mission (United States)

    Burch, James

    Magnetospheric Multiscale (MMS), a NASA four-spacecraft mission scheduled for launch in November 2014, will investigate magnetic reconnection in the boundary regions of the Earth’s magnetosphere, particularly along its dayside boundary with the solar wind and the neutral sheet in the magnetic tail. Among the important questions about reconnection that will be addressed are the following: Under what conditions can magnetic-field energy be converted to plasma energy by the annihilation of magnetic field through reconnection? How does reconnection vary with time, and what factors influence its temporal behavior? What microscale processes are responsible for reconnection? What determines the rate of reconnection? In order to accomplish its goals the MMS spacecraft must probe both those regions in which the magnetic fields are very nearly antiparallel and regions where a significant guide field exists. From previous missions we know the approximate speeds with which reconnection layers move through space to be from tens to hundreds of km/s. For electron skin depths of 5 to 10 km, the full 3D electron population (10 eV to above 20 keV) has to be sampled at rates greater than 10/s. The MMS Fast-Plasma Instrument (FPI) will sample electrons at greater than 30/s. Because the ion skin depth is larger, FPI will make full ion measurements at rates of greater than 6/s. 3D E-field measurements will be made by MMS once every ms. MMS will use an Active Spacecraft Potential Control device (ASPOC), which emits indium ions to neutralize the photoelectron current and keep the spacecraft from charging to more than +4 V. Because ion dynamics in Hall reconnection depend sensitively on ion mass, MMS includes a new-generation Hot Plasma Composition Analyzer (HPCA) that corrects problems with high proton fluxes that have prevented accurate ion-composition measurements near the dayside magnetospheric boundary. Finally, Energetic Particle Detector (EPD) measurements of electrons and

  19. The SCOPE Mission

    International Nuclear Information System (INIS)

    Fujimoto, M.; Tsuda, Y.; Saito, Y.; Shinohara, I.; Takashima, T.; Matsuoka, A.; Kojima, H.; Kasaba, Y.


    In order to reach the new horizon of the space physics research, the Plasma Universe, via in-situ measurements in the Earth's magnetosphere, SCOPE will perform formation flying observations combined with high-time resolution electron measurements. The simultaneous multi-scale observations by SCOPE of various plasma dynamical phenomena will enable data-based study of the key space plasma processes from the cross-scale coupling point of view. Key physical processes to be studied are magnetic reconnection under various boundary conditions, shocks in space plasma, collisionless plasma mixing at the boundaries, and physics of current sheets embedded in complex magnetic geometries. The SCOPE formation is made up of 5 spacecraft and is put into the equatorial orbit with the apogee at 30 Re (Re: earth radius). One of the spacecraft is a large mother ship which is equipped with a full suite of particle detectors including ultra-high time resolution electron detector. Among other 4 small spacecraft, one remains near (∼10 km) the mother ship and the spacecraft-pair will focus on the electron-scale physics. Others at the distance of 100∼3000 km(electron∼ion spatial scales) from the mother ship will monitor plasma dynamics surrounding the mother-daughter pair. There is lively on-going discussion on Japan-Europe international collaboration (ESA's Cross-Scale), which would certainly make better the coverage over the scales of interest and thus make the success of the mission, i.e., clarifying the multi-scale nature of the Plasma Universe, to be attained at an even higher level.

  20. Synthesis of dispersive iron or iron–silver nanoparticles on engineered capsid pVIII of M13 virus with electronegative terminal peptides

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Shuai; Nakano, Kazuhiko; Zhang, Shu-liang; Yu, Hui-min, E-mail: [Tsinghua University, Key Laboratory of Industrial Biocatalysis of the Ministry of Education, Department of Chemical Engineering (China)


    M13 is a filamentous Escherichia coli virus covered with five types of capsid proteins, in which pVIII with ∼2700 copies was around the cylindered surface and pIII with five copies located at one end of the phage particle. The pIII-engineered M13 phages with enhanced binding specificity toward Fe were screened after five rounds of biopanning, and the one containing ATPTVAMSLSPL peptide at pIII-terminus was selected for mediated synthesis of zero valent (ZV) Fe nanoparticles (NPs) with the wild M13 as control. Under a reducing environment, uniformly dispersed ZVFeNPs with diameter of 5–10 nm were both synthesized and the morphologies after annealing were confirmed to be face-centered cubic type. The synthesized FeNPs mediated by the two phages showed no significant difference, revealing that the pVIII capsid did dominant contribution to metal binding in comparison with the pIII. A novel pVIII-engineered M13 containing AAEEEDPAK at terminus, named as 4ED-pVIII-M13, was constructed and it carried one more negatively charged residue than the wild one (AEGDDPAK). Metal adsorption quantification showed that the binding affinity of the 4ED-pVIII-M13 toward Ag and Ni ions improved to 62 and 18 % from original 21 and 6 %, respectively. The binding affinity toward Fe remained constant (∼85 %). ZVFe–Ag bi-NPs were successfully synthesized through mediation of 4ED-pVIII-M13. Particularly, the Fe:Ag ratio in the bi-NPs was conveniently controlled through changing the molar concentration of FeCl{sub 2} and AgNO{sub 3} solution before reduction.

  1. Una frontera casi invisible: los territorios al norte del Sistema Central en la Alta Edad Media (siglos VIII-XI

    Directory of Open Access Journals (Sweden)



    Full Text Available RESUMEN: Los territorios al norte del Sistema Central no estuvieron sujetos a un dominio por parte de una autoridad centralizada entre los siglos VIII a XI. Los instrumentos del poder central, en especial la tributación y la organización episcopal, se descompusieron tras el siglo VIII y asumieron un papel determinante las estructuras de poder local, las cuales deben ser el principal objeto de estudio. A partir de su análisis, se descubre un espacio fronterizo abierto, con un dominio político informal, que es invisible para los poderes centrales. Palabras clave: Poderes Locales. Sitios de Altura. Necrópolis. Frontera. Tributación. Mozárabes.ABSTRACT: The territories at the North of the Iberian Central System were not ruled by any central authority between eighth and eleventh centuries. The main tools of the central power, especially the tribute and the episcopal organization, were broken down after the 8th century and the structures of local power, which must be studied particularly, got a very influential role. The analysis discover an opened frontier area, with an informal political control, that is invisible from the perspective of the central power

  2. Effectiveness of Adaptive Contextual Learning Model of Integrated Science by Integrating Digital Age Literacy on Grade VIII Students (United States)

    Asrizal, A.; Amran, A.; Ananda, A.; Festiyed, F.


    Educational graduates should have good competencies to compete in the 21st century. Integrated learning is a good way to develop competence of students in this century. Besides that, literacy skills are very important for students to get success in their learning and daily life. For this reason, integrated science learning and literacy skills are important in 2013 curriculum. However, integrated science learning and integration of literacy in learning can’t be implemented well. Solution of this problem is to develop adaptive contextual learning model by integrating digital age literacy. The purpose of the research is to determine the effectiveness of adaptive contextual learning model to improve competence of grade VIII students in junior high school. This research is a part of the research and development or R&D. Research design which used in limited field testing was before and after treatment. The research instruments consist of three parts namely test sheet of learning outcome for assessing knowledge competence, observation sheet for assessing attitudes, and performance sheet for assessing skills of students. Data of student’s competence were analyzed by three kinds of analysis, namely descriptive statistics, normality test and homogeneity test, and paired comparison test. From the data analysis result, it can be stated that the implementation of adaptive contextual learning model of integrated science by integrating digital age literacy is effective to improve the knowledge, attitude, and literacy skills competences of grade VIII students in junior high school at 95% confidence level.

  3. Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs (United States)

    Dumont, Jennifer A.; Liu, Tongyao; Low, Susan C.; Zhang, Xin; Kamphaus, George; Sakorafas, Paul; Fraley, Cara; Drager, Douglas; Reidy, Thomas; McCue, Justin; Franck, Helen W. G.; Merricks, Elizabeth P.; Nichols, Timothy C.; Bitonti, Alan J.; Pierce, Glenn F.


    Despite proven benefits, prophylactic treatment for hemophilia A is hampered by the short half-life of factor VIII. A recombinant factor VIII-Fc fusion protein (rFVIIIFc) was constructed to determine the potential for reduced frequency of dosing. rFVIIIFc has an ∼ 2-fold longer half-life than rFVIII in hemophilia A (HemA) mice and dogs. The extension of rFVIIIFc half-life requires interaction of Fc with the neonatal Fc receptor (FcRn). In FcRn knockout mice, the extension of rFVIIIFc half-life is abrogated, and is restored in human FcRn transgenic mice. The Fc fusion has no impact on FVIII-specific activity. rFVIIIFc has comparable acute efficacy as rFVIII in treating tail clip injury in HemA mice, and fully corrects whole blood clotting time (WBCT) in HemA dogs immediately after dosing. Furthermore, consistent with prolonged half-life, rFVIIIFc shows 2-fold longer prophylactic efficacy in protecting HemA mice from tail vein transection bleeding induced 24-48 hours after dosing. In HemA dogs, rFVIIIFc also sustains partial correction of WBCT 1.5- to 2-fold longer than rFVIII. rFVIIIFc was well tolerated in both species. Thus, the rescue of FVIII by Fc fusion to provide prolonged protection presents a novel pathway for FVIII catabolism, and warrants further investigation. PMID:22246033

  4. Il ruolo di El Escorial, V.III.6 e dei suoi discendenti nella tradizione manoscritta del Lucullus

    Directory of Open Access Journals (Sweden)

    Corinna Senore


    Full Text Available L’articolo riguarda un gruppo di sette codici che tramanda il testo del Lucullus di Cicerone e che appartiene al ramo della tradizione discendente dal manoscritto Wien, Österreichische Nationalbibliothek 189. I sette manoscritti costituiscono uno stadio della tradizione caratterizzato dalla presenza di tre lacune testuali. Sulla base di alcuni elementi paleografici e della presenza di una glossa riportata a margine del testo di uno di essi, El Escorial, V.III.6 (Scor4, e inglobata all’interno del testo degli altri sei, è possibile individuare in Scor4 il capostipite di questo gruppo della tradizione. Lo studio si occupa inoltre di fare chiarezza sui rapporti che intercorrono tra i sei discendenti di Scor4. The article focuses on a group of seven codices which carry the text of Cicero’s Lucullus. This group belongs to the branch of the tradition descending from the manuscript Wien, Österreichische Nationalbibliothek 189. The seven manuscripts represent a step of the tradition marked by the presence of some textual lacunas. I start from some paleographic elements and from the presence of a gloss on text’s margin of one of them, El Escorial, V.III.6 (Scor4. The gloss has been then incorporated in the text of the other six manuscripts and I assume that Scor4 is the founder of this group of tradition. Furthermore, this article aims to clarify the relations between the six descendants of Scor4.

  5. Pisanello’s hat. The costume and weapons depicted in Pisanello’s medal for John VIII Palaeologus. A discussion of the saber and related weapons

    Directory of Open Access Journals (Sweden)

    Alexander, David


    Full Text Available A group of six drawings by the Veronese artist Antonio Pisano depicted the Bizantine Emperor John VIII Paleologus wearing costumes and weapons according to islamic types. This paper studies these objects in relation to other contemporary islamic weapons.

    Un grupo de seis dibujos del artista veronés Antonio Pisano representa al emperador bizantino Juan VIII Paleólogo vestido y armado según modelos islámicos. Este trabajo estudia dichos objetos en relación a otras armas islámicas contemporáneas.

  6. Pengembangan Perangkat Pembelajaran Matematika Berbasis Problem Based Learning (PBL untuk Meningkatkan Kemampuan Pemecahan Masalah Peserta Didik Kelas VIII

    Directory of Open Access Journals (Sweden)

    Rizza Yustianingsih


    Full Text Available Abstrak. Berdasarkan hasil penelitian pendahuluan pada kelas VIII SMP di lapangan, masih ditemukan kemampuan pemecahan masalah matematis siswa dalam masalah nyata yang belum optimal dan aktivitas siswa tidak mendukung proses belajar mereka. Salah satu faktornya adalah tidak cocoknya perangkat pembelajaran yang dapat memudahkan pembelajar untuk memperbaiki pemecahan kemampuan matematika dan kemampuan belajar siswa. Dari situ, untuk mendasari melakukan pengembangan perangkat pembelajaran matematika, ada rencana rencana pembelajaran (RPP dan lembar kerja siswa (LKPD berbasis Problem Based Learning (PBL, yang dapat memberikan pengalaman belajar untuk belajar pemecahan masalah dan dapat memberikan efek potensial yang baik pada aktivitas siswa selama proses belajar. Data dikumpulkan melalui observasi, kuesioner, wawancara, dan uji kemampuan pemecahan masalah. Subyek penelitian ini adalah siswa kelas VIII SMP N 3 Sawahlunto. Pengembangan penelitian ini yang digunakan adalah mode Plomp yang terdiri dari tahap awal penelitian, tahap prototipe, dan tahap penilaian. Berdasarkan hasil analisis data, terlihat bahwa alat pembelajaran berdasarkan PBL telah memenuhi kriteria yang valid dalam hal isi dan konstruksi. Peralatan pelajaran telah dianggap praktis dalam hal pelaksanaan dan efisiensi penggunaan waktu oleh guru dan siswa. Alat pelajaran juga efektif dalam hal proses penguasaan presentasi siswa belajar setelah menggunakan pembelajaran berbasis perangkat berbasis pembelajaran lebih besar dari atau sama dengan 75% sedangkan dalam hal hasil rata-rata siswa telah aktif dalam belajar. Kata kunci: Perangkat Pelajaran Matematika, Pemecahan Masalah, PBL.   Abstract. Based on the results of preliminary studies at grade VIII SMP in the field, it is still  found a mathematical problem solving ability of students in real problem who have not optimally and students activities do not support their learning process. One of the  factor is unsuitable of learning tools

  7. Executive Summary - Our mission

    International Nuclear Information System (INIS)


    On September 1 st 2003, the Henryk Niewodniczanski Institute of Nuclear Physics in Cracow joined the Polish Academy of Sciences. The Polish Academy of Sciences (PAN), founded in 1952, is a state-sponsored scientific institution acting through an elected corporation of leading scholars, their research organizations and through numerous scientific establishments. PAN is a major national scientific advisory body acting via its scientific committees which represent all disciplines of science. There are currently 79 PAN research establishments (institutes and research centers, research stations, botanical gardens and other research units) and a number of auxiliary scientific units (such as archives, libraries, museums, and PAN stations abroad). Our Institute is currently one of the largest research institutions of the Polish Academy of Sciences. The research activity of the Academy is financed mainly from the State budget via the Ministry of Scientific Research and Information Technology. The mission of the Institute of Nuclear Physics, IFJ is stated in its Charter. According to Paragraphs 5, 6, and 7 of the 2004 Charter, the Institute's duty is to carry out research activities in the following areas:1. High energy and elementary particle physics (including astrophysics), 2. Nuclear physics and physics of mechanisms of nuclear interaction, 3. Condensed matter physics, 4. Interdisciplinary research, and in particular: in radiation and environmental biology, environmental physics, medical physics, dosimetry, nuclear geophysics, radiochemistry and material engineering. The main tasks of the Institute are: 1. To perform research in the above disciplines, 2. To promote the development of scientists and of specialists qualified to carry out research in these disciplines, 3. To organize a Post-Doctoral Study Course, 4. To permit, through agreements with national and foreign research institutions, external scholars to train and gain academic qualifications in the Institute

  8. The Ulysses mission: An introduction

    International Nuclear Information System (INIS)

    Marsden, R.G.


    On 30 September 1995, Ulysses completed its initial, highly successful, survey of the polar regions of the heliosphere in both southern and northern hemispheres, thereby fulfilling its prime mission. The results obtained to date are leading to a revision of many earlier ideas concerning the solar wind and the heliosphere. Now embarking on the second phase of the mission, Ulysses will continue along its out-of-ecliptic flight path for another complete orbit of the Sun. In contrast to the high-latitude phase of the prime mission, which occurred near solar minimum, the next polar passes (in 2000 and 2001) will take place when the Sun is at its most active

  9. International partnership in lunar missions

    Indian Academy of Sciences (India)

    related to space science and Moon missions are being addressed in this conference. .... flight. The studies in India suggest that an 'aerobic' space transportation vehicle can indeed have a ... space from Earth at very, very low cost first before.

  10. Telepresence for Deep Space Missions (United States)

    National Aeronautics and Space Administration — Incorporating telepresence technologies into deep space mission operations can give the crew and ground personnel the impression that they are in a location at time...

  11. Mission Level Autonomy for USSV (United States)

    Huntsberger, Terry; Stirb, Robert C.; Brizzolara, Robert


    On-water demonstration of a wide range of mission-proven, advanced technologies at TRL 5+ that provide a total integrated, modular approach to effectively address the majority of the key needs for full mission-level autonomous, cross-platform control of USV s. Wide baseline stereo system mounted on the ONR USSV was shown to be an effective sensing modality for tracking of dynamic contacts as a first step to automated retrieval operations. CASPER onboard planner/replanner successfully demonstrated realtime, on-water resource-based analysis for mission-level goal achievement and on-the-fly opportunistic replanning. Full mixed mode autonomy was demonstrated on-water with a seamless transition between operator over-ride and return to current mission plan. Autonomous cooperative operations for fixed asset protection and High Value Unit escort using 2 USVs (AMN1 & 14m RHIB) were demonstrated during Trident Warrior 2010 in JUN 2010

  12. Green Propellant Infusion Mission Program (United States)

    National Aeronautics and Space Administration — The mission is architected as a collaboration of NASA, Industry, and Air Force partners with the objective to advance the technology for propulsion components using...

  13. Urinary albumin in space missions

    DEFF Research Database (Denmark)

    Cirillo, Massimo; De Santo, Natale G; Heer, Martina


    Proteinuria was hypothesized for space mission but research data are missing. Urinary albumin, as index of proteinuria, was analyzed in frozen urine samples collected by astronauts during space missions onboard MIR station and on ground (control). Urinary albumin was measured by a double antibody...... radioimmunoassay. On average, 24h urinary albumin was 27.4% lower in space than on ground; the difference was statistically significant. Low urinary albumin excretion could be another effect of exposure to weightlessness (microgravity)....

  14. KEPLER Mission: development and overview

    International Nuclear Information System (INIS)

    Borucki, William J


    The Kepler Mission is a space observatory launched in 2009 by NASA to monitor 170 000 stars over a period of four years to determine the frequency of Earth-size and larger planets in and near the habitable zone of Sun-like stars, the size and orbital distributions of these planets, and the types of stars they orbit. Kepler is the tenth in the series of NASA Discovery Program missions that are competitively-selected, PI-directed, medium-cost missions. The Mission concept and various instrument prototypes were developed at the Ames Research Center over a period of 18 years starting in 1983. The development of techniques to do the 10 ppm photometry required for Mission success took years of experimentation, several workshops, and the exploration of many ‘blind alleys’ before the construction of the flight instrument. Beginning in 1992 at the start of the NASA Discovery Program, the Kepler Mission concept was proposed five times before its acceptance for mission development in 2001. During that period, the concept evolved from a photometer in an L2 orbit that monitored 6000 stars in a 50 sq deg field-of-view (FOV) to one that was in a heliocentric orbit that simultaneously monitored 170 000 stars with a 105 sq deg FOV. Analysis of the data to date has detected over 4600 planetary candidates which include several hundred Earth-size planetary candidates, over a thousand confirmed planets, and Earth-size planets in the habitable zone (HZ). These discoveries provide the information required for estimates of the frequency of planets in our galaxy. The Mission results show that most stars have planets, many of these planets are similar in size to the Earth, and that systems with several planets are common. Although planets in the HZ are common, many are substantially larger than Earth. (review article)

  15. TRISTAN - mission complete

    International Nuclear Information System (INIS)



    The high energy physics mission of the TRISTAN electron-positron collider at the Japanese KEK Laboratory ended in May. TRISTAN was the first accelerator in Japan at the high energy frontier, and its success owes a great deal to help and encouragement from the world high energy physics community. Its success also marks the first step toward the KEKB project now underway and the subsequent Linear Collider scheme. TRISTAN began operation in November 1986 with a collision energy of 50 GeV, the world's highest electron-positron collision energy at that time. With the addition of superconducting radiofrequency cavities, the energy was continuously increased, reaching a maximum of 64 GeV in 1989. In this exploratory era, the three large detectors - AMY,TOPAZ and VENUS - together with the smaller SHIP group made a rapid survey of particle phenomena in this new energy range. The sixth ('top') quark was first on the list of wanted particles, but the three large groups concluded that there were no new quarks below 32 GeV. The CDF and DO Collaborations at Fermilab's Tevatron recently reported the top quark as being six times as heavy as TRISTAN'S physics reach. Although initial experimental results suggested that the event-shape distributions of multi-hadron events were broadly consistent with the production of the five known quarks, the production rate of hadrons, compared to muons, was seen to rise with energy. The increased energy reach of TRISTAN increased the visibility of the subtle virtual effects of the Z (the electrically neutral carrier of the weak force) produced through the interference of weak and electromagnetic interactions. The rise was found to be slightly larger than expected from five quarks and a Z mass of 92 or 93 GeV, the accepted value at that time. This hinted that the Z mass had to be smaller, as later verified when the SLC and LEP electron-positron colliders at SLAC (Stanford) and CERN respectively came into operation in 1989

  16. Executive Summary - Our mission

    International Nuclear Information System (INIS)


    Full text: The Henryk Niewodniczanski Institute of Nuclear Physics (Instytut Fizyki Jadrowej im. Henryka Niewodniczanskiego, IFJ PAN) is currently the largest research institution of the Polish Academy of Sciences (Polska Akademia Nauk). The research activity of the Academy is financed mainly from the State budget via the Ministry of Science and Higher Education. The mission of IFJ PAN is stated in its Charter. According to Paragraphs 5, 6, and 7 of the 2004 Charter, the Institute's duty is to carry out research activities in the following areas: 1. High energy and elementary particle physics (including astrophysics), 2. Nuclear physics and strong interaction, 3. Condensed matter physics, 4. Interdisciplinary research, in particular: in radiation and environmental biology, environmental physics, medical physics, dosimetry, nuclear geophysics, radiochemistry and material engineering. The main tasks of the Institute are: 1. To perform research in the above disciplines, 2. To promote the development of scientists and of specialists qualified to carry out research in these disciplines, 3. To organize a Post-Graduate Study Course, 4. To permit, through agreements with national and foreign research institutions, external scholars to train and gain academic qualifications in the Institute's laboratories, 5. To collaborate with national and local authorities in providing them with expertise in the Institute's research topics, especially concerning radiation protection. These tasks are fulfilled by: 1. Performing individual and coordinated research through individual and collective research grant projects, 2. Initiating and maintaining cooperation with laboratories, organizations and institutions performing similar activities, in Poland and abroad, 3. Conferring scientific degrees and titles, 4. Distributing research results obtained, through peer-reviewed publications and other public media, 5. Organizing scientific meetings, conferences, symposia, training workshops, etc

  17. Psychosocial interactions during ISS missions (United States)

    Kanas, N. A.; Salnitskiy, V. P.; Ritsher, J. B.; Gushin, V. I.; Weiss, D. S.; Saylor, S. A.; Kozerenko, O. P.; Marmar, C. R.


    Based on anecdotal reports from astronauts and cosmonauts, studies of space analog environments on Earth, and our previous research on the Mir Space Station, a number of psychosocial issues have been identified that can lead to problems during long-duration space expeditions. Several of these issues were studied during a series of missions to the International Space Station. Using a mood and group climate questionnaire that was completed weekly by crewmembers in space and personnel in mission control, we found no evidence to support the presence of predicted decrements in well-being during the second half or in any specific quarter of the missions. The results did support the predicted displacement of negative feelings to outside supervisors among both crew and ground subjects. There were several significant differences in mood and group perceptions between Americans and Russians and between crewmembers and mission control personnel. Crewmembers related cohesion to the support role of their leader, and mission control personnel related cohesion to both the task and support roles of their leader. These findings are discussed with reference to future space missions.

  18. Social Tagging of Mission Data (United States)

    Norris, Jeffrey S.; Wallick, Michael N.; Joswig, Joseph C.; Powell, Mark W.; Torres, Recaredo J.; Mittman, David S.; Abramyan, Lucy; Crockett, Thomas M.; Shams, Khawaja S.; Fox, Jason M.; hide


    Mars missions will generate a large amount of data in various forms, such as daily plans, images, and scientific information. Often, there is a semantic linkage between images that cannot be captured automatically. Software is needed that will provide a method for creating arbitrary tags for this mission data so that items with a similar tag can be related to each other. The tags should be visible and searchable for all users. A new routine was written to offer a new and more flexible search option over previous applications. This software allows users of the MSLICE program to apply any number of arbitrary tags to a piece of mission data through a MSLICE search interface. The application of tags creates relationships between data that did not previously exist. These tags can be easily removed and changed, and contain enough flexibility to be specifically configured for any mission. This gives users the ability to quickly recall or draw attention to particular pieces of mission data, for example: Give a semantic and meaningful description to mission data; for example, tag all images with a rock in them with the tag "rock." Rapidly recall specific and useful pieces of data; for example, tag a plan as"driving template." Call specific data to a user s attention; for example, tag a plan as "for:User." This software is part of the MSLICE release, which was written in Java. It will run on any current Windows, Macintosh, or Linux system.

  19. Low Thrust Trajectory Design for GSFC Missions (United States)

    National Aeronautics and Space Administration — The Evolutionary Mission Trajectory Generator (EMTG) is a global trajectory optimization tool. EMTG is intended for use in designing interplanetary missions which...

  20. A review of Spacelab mission management approach (United States)

    Craft, H. G., Jr.


    The Spacelab development program is a joint undertaking of the NASA and ESA. The paper addresses the initial concept of Spacelab payload mission management, the lessons learned, and modifications made as a result of the actual implementation of Spacelab Mission 1. The discussion covers mission management responsibilities, program control, science management, payload definition and interfaces, integrated payload mission planning, integration requirements, payload specialist training, payload and launch site integration, payload flight/mission operations, and postmission activities. After 3.5 years the outlined overall mission manager approach has proven to be most successful. The approach does allow the mission manager to maintain the lowest overall mission cost.

  1. Recurrent myocardial infarctions in a young football player secondary to thrombophilia, associated with elevated factor VIII activity

    Directory of Open Access Journals (Sweden)

    Vacek TP


    Full Text Available Thomas P Vacek, Shipeng Yu, Shahnaz Rehman, Blair P Grubb, Daniel Kosinski, Cherian Verghese, Ehab A Eltahawy, Shafiq Qaiser Department of Medicine, University of Toledo Medical Center, Toledo, OH, USAAbstract: Myocardial infarction (MI due to coronary atherosclerosis in young adults is uncommon; rare causes such as cocaine abuse, arterial dissection, and thromboembolism should be considered. A 21-year-old football player, and otherwise healthy African American man, developed chest pain during exercise while bench-pressing 400 lbs. Acute MI was diagnosed based on physical examination, electrocardiography findings, and elevated cardiac enzymes. Coronary arteriography showed a thrombus occluding the proximal left anterior descending artery (LAD. Aggressive antiplatelet therapy with aspirin, clopidogrel, and eptifibatide was pursued, in addition to standard post-MI care. This led to the successful resolution of symptoms and dissolution of the thrombus, demonstrated by repeat coronary arteriography. Five months later, he presented with similar symptoms during exercise after lifting heavy weights, and was found to have another acute MI. Coronary arteriography again showed a thrombus occluding the LAD. No evidence of coronary artery dissection or vasospasm was found. Only mild atherosclerotic plaque burden was observed on both occasions by intravascular ultrasound. A bare metal stent was placed at the site as it was thought this site had acted as a nidus for small plaque rupture and thrombus formation. Elevated serum factor VIII activity at 205% (reference range 60%–140% was found, a rare cause of hypercoagulability. Further workup revealed a patent foramen ovale during a Valsalva maneuver by transesophageal echocardiography. Both events occurred during weight lifting, which can transiently increase right heart pressure in a similar way to the Valsalva maneuver. In light of all the findings, we concluded that an exercise-related increase in factor

  2. Analisis Deskriptif Soal Geometri dalam Buku Matematika Bilingual untuk Sekolah Menengah Pertama Kelas VIII Berdasarkan Kriteria International Assessment TIMSS 2007

    Directory of Open Access Journals (Sweden)

    Etik Rahayu


    Full Text Available Tujuan penelitian ini adalah untuk mendeskripsikan  domain kognitif dan aspek kognitif (required behavior soal matematika dalam Buku Matematika Bilingual untuk Sekolah Menengah Pertama (SMP Kelas VIII berdasarkan kriteria International Assessment TIMSS 2007 dan proporsinya. Metode penelitian yang digunakan adalah deskriptif kualitatif, dengan subjek penelitian adalah soal geometri dalam Buku Matematika Bilingual SMP. yang berjudul “Mathematics for Junior High School Grade VIII 1st Semester” dan “Mathematics for Junior High School Grade VIII 2nd Semester” karangan karangan M. Cholik Adinawan dan Sugijono. Pengumpulan data menggunakan metode observasi dan wawancara tentang penggunaan buku matematika bilingual yang paling banyak digunakan di kota semarang. Pedoman analisis soal berdasarkan kriteria International Assessment TIMSS 2007, dengan validasi hasil oleh ahli. Hasil penelitian menunjukkan bahwa soal yang dianalisis memuat satu hingga tujuh aspek kognitif. Sebagian besar soal memuat 4 aspek kognitif yaitu 44.04 %, diikuti soal dengan 3 aspek kognitif  yaitu 36, 42%,  soal dengan 2 aspek kognitif yaitu 14, 90%, kemudian 1,99% untuk soal dengan 1 atau 5 aspek kognitif, dan 0,33% untuk soal dengan 6 atau 7 aspek kognitif. Proporsi tinggi pada recall (28.26% dan compute (26.57%, diikuti dengan SRP (10.85%, implement (10.65%, retrieve (8.36%, recognize (6.17%, analyze (1.99%, measure (1.59%, generalize (1.09%, SNRP (1.00%, classify (0.80%, represent (0.80%, justify (0.80%, select (0.60%, model (0.30%, synthesis (0.20%. Secara keseluruhan berdasarkan International Assessment TIMSS 2007 soal yang termasuk domain knowing memiliki persentase paling tinggi (52.28%, domain knowing-applying (24.83%, domain knowing- reasoning (12.91%, dan hanya sedikit yang termasuk domain knowing-apllying-reasoning (3.97%. Serta terdapat 4 soal (1.32% yang mempunyai ketidaksesuaian penggunaan mathematics terms serta 1 soal (0

  3. The Asteroid Redirect Mission (ARM) (United States)

    Abell, Paul; Gates, Michele; Johnson, Lindley; Chodas, Paul; Mazanek, Dan; Reeves, David; Ticker, Ronald


    To achieve its long-term goal of sending humans to Mars, the National Aeronautics and Space Administration (NASA) plans to proceed in a series of incrementally more complex human spaceflight missions. Today, human flight experience extends only to Low-Earth Orbit (LEO), and should problems arise during a mission, the crew can return to Earth in a matter of minutes to hours. The next logical step for human spaceflight is to gain flight experience in the vicinity of the Moon. These cis-lunar missions provide a "proving ground" for the testing of systems and operations while still accommodating an emergency return path to the Earth that would last only several days. Cis-lunar mission experience will be essential for more ambitious human missions beyond the Earth-Moon system, which will require weeks, months, or even years of transit time. In addition, NASA has been given a Grand Challenge to find all asteroid threats to human populations and know what to do about them. Obtaining knowledge of asteroid physical properties combined with performing technology demonstrations for planetary defense provide much needed information to address the issue of future asteroid impacts on Earth. Hence the combined objectives of human exploration and planetary defense give a rationale for the Asteroid Re-direct Mission (ARM). Mission Description: NASA's ARM consists of two mission segments: 1) the Asteroid Redirect Robotic Mission (ARRM), the first robotic mission to visit a large (greater than ~100 m diameter) near-Earth asteroid (NEA), collect a multi-ton boulder from its surface along with regolith samples, demonstrate a planetary defense technique, and return the asteroidal material to a stable orbit around the Moon; and 2) the Asteroid Redirect Crewed Mission (ARCM), in which astronauts will take the Orion capsule to rendezvous and dock with the robotic vehicle, conduct multiple extravehicular activities to explore the boulder, and return to Earth with samples. NASA's proposed

  4. Low-dose factor VIII infusion in Chinese adult haemophilia A patients: pharmacokinetics evidence that daily infusion results in higher trough level than with every-other-day infusion with similar factor VIII consumption. (United States)

    Hua, B; Lee, A; Fan, L; Li, K; Zhang, Y; Poon, M-C; Zhao, Y


    Pharmacokinetics (PK) modelling suggests improvement of trough levels are achieved by using more frequent infusion strategy. However, no clinical study data exists to confirm or quantify improvement in trough level, particularly for low-dose prophylaxis in patients with haemophilia A. To provide evidence that low dose daily (ED) prophylaxis can increase trough levels without increasing FVIII consumption compared to every-other-day (EOD) infusion. A cross-over study on 5 IU kg -1 FVIII daily vs. 10 IU kg -1 EOD infusions, each for 14 days was conducted at the PUMCH-HTC. On the ED schedule, trough (immediate prior to infusion), and peak FVIII:C levels (30 min after infusion) were measured on days 1-5; and trough levels alone on days 7, 9, 11 and 13. For the EOD schedule, troughs, peaks and 4-h postinfusion were measured on day 1; troughs and peaks on days 3, 5, and 7; troughs alone on days 9, 11 and 13 and 24-h postinfusion on days 2, 4 and 6. FVIII inhibitors were assessed on days 0 and 14 during both infusion schedules. Six patients were enrolled. PK evidence showed that daily prophylaxis achieved higher (~2 times) steady-state FVIII trough levels compared to EOD with the same total factor consumption. The daily prophylaxis had good acceptability among patients and reduced chronic pain in the joints in some patients. Our PK study shows low-dose factor VIII daily infusion results in higher trough level than with EOD infusion with similar factor VIII consumption in Chinese adult haemophilia A patients. © 2017 John Wiley & Sons Ltd.

  5. Prediction of human pharmacokinetics of activated recombinant factor VII and B-domain truncated factor VIII from animal population pharmacokinetic models of haemophilia

    DEFF Research Database (Denmark)

    Larsen, Malte Selch; Juul, Rasmus Vestergaard; Groth, Andreas Velsing


    activated factor VII (rFVIIa) and recombinant factor VIII (rFVIII) in several experimental animal models using population PK modelling, and apply a simulation-based approach to evaluate how well the developed animal population PK models predict human PK. PK models were developed for rFVIIa and r...

  6. 20 CFR 404.535 - How much will we withhold from your title VIII and title XVI benefits to recover a title II... (United States)


    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false How much will we withhold from your title... Officer § 404.535 How much will we withhold from your title VIII and title XVI benefits to recover a title II overpayment? (a) If past-due benefits are payable to you, we will withhold the lesser of the...

  7. Report on corrections and future considerations for Appendices II–VIII of the International Code of Nomenclature for Algae, Fungi, and Plants (United States)

    For the first time, the main text and Appendices II–VIII of the International Code of Nomenclature were separately published following decisions of the Melbourne Nomenclature Section, which contributed to subsequent development of an online resource capable of producing the Appendices in real time. ...

  8. Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic-guided prophylaxis

    NARCIS (Netherlands)

    Valentino, L. A.; Pipe, S. W.; Collins, P. W.; Blanchette, V. S.; Berntorp, E.; Fischer, K.; Ewenstein, B. M.; Oh, M.; Spotts, G.


    Introduction: We previously showed that pharmacokinetic-guided prophylaxis (PKP) allows the dosing interval to be extended while maintaining a specific trough level. However, the associations of peak factor VIII (FVIII) levels and area under the curve (AUC) with breakthrough bleeding have not been

  9. Significantly improved surface morphology of N-polar GaN film grown on SiC substrate by the optimization of V/III ratio (United States)

    Deng, Gaoqiang; Zhang, Yuantao; Yu, Ye; Yan, Long; Li, Pengchong; Han, Xu; Chen, Liang; Zhao, Degang; Du, Guotong


    In this paper, N-polar GaN films with different V/III ratios were grown on vicinal C-face SiC substrates by metalorganic chemical vapor deposition. During the growth of N-polar GaN film, the V/III ratio was controlled by adjusting the molar flow rate of ammonia while keeping the trimethylgallium flow rate unchanged. The influence of the V/III ratio on the surface morphology of N-polar GaN film has been studied. We find that the surface root mean square roughness of N-polar GaN film over an area of 20 × 20 μm2 can be reduced from 8.13 to 2.78 nm by optimization of the V/III ratio. Then, using the same growth conditions, N-polar InGaN/GaN multiple quantum wells (MQWs) light-emitting diodes (LEDs) were grown on the rough and the smooth N-polar GaN templates, respectively. Compared with the LED grown on the rough N-polar GaN template, dramatically improved interface sharpness and luminescence uniformity of the InGaN/GaN MQWs are achieved for the LED grown on the smooth N-polar GaN template.

  10. Retsensioon : Riigikogu VII, VIII ja IX koosseis. Statistikat ja kommentaare. Peatoimetaja Aaro Mõttus. Tallinn : Riigikogu Kantselei, Eesti Rahvusraamatukogu, 2004. 326 lk. / Mart Nutt

    Index Scriptorium Estoniae

    Nutt, Mart, 1962-


    Arvustus: Riigikogu VII, VIII ja IX koosseis. Statistikat ja kommentaare / peatoim. Aaro Mõttus. Tallinn : Riigikogu Kantselei, Eesti Rahvusraamatukogu, 2004. - Lisatud: Ott Heinapuu tutvustav sõnum retsenseeritud väljaande kohta lk. 193. - Vt. ka:

  11. Understanding the first Neolithic occupation of Cova d'En Pardo (Planes, Alicante: Preliminary results of the multidisciplinary analysis of levels VIII and VIIIB

    Directory of Open Access Journals (Sweden)

    Jorge Agatángelo Soler Díaz


    Full Text Available We present the results of excavations carried out in the Cova d'En Pardo (Planes, Alicante, specifically the levels VIII and VIIIb. The development of a multidisciplinary project has allowed to us characterize the occupation of a small cavity by the first farming communities associated with the Neolithization process of the east of Iberian Peninsula.

  12. Hemophilia as a defect of the tissue factor pathway of blood coagulation: Effect of factors VIII and IX on factor X activation in a continuous-flow reactor

    International Nuclear Information System (INIS)

    Repke, D.; Gemmell, C.H.; Guha, A.; Turitto, V.T.; Nemerson, Y.; Broze, G.J. Jr.


    The effect of factors VIII and IX on the ability of the tissue factor-factor VIIa complex to activate factor X was studied in a continuous-flow tubular enzyme reactor. Tissue factor immobilized in a phospholipid bilayer on the inner surface of the tube was exposed to a perfusate containing factors VIIa, VIII, IX, and X flowing at a wall shear rate of 57, 300, or 1130 sec -1 . The addition of factors VIII and IX at their respective plasma concentrations resulted in a further 2 endash-to 3 endash fold increase. The direct activation of factor X by tissue factor-factor VIIa could be virtually eliminated by the lipoprotein-associated coagulation inhibitor. These results suggest that the tissue factor pathway, mediated through factors VIII and IX, produces significant levels of factor Xa even in the presence of an inhibitor of the tissue factor-factor VIIa complex; moreover, the activation is dependent on local shear conditions. These findings are consistent both with a model of blood coagulation in which initiation of the system results from tissue factor and with the bleeding observed in hemophilia

  13. Expressão citofotométrica dos marcadores tumorais CD-34 e fator VIII no câncer de cólon

    Directory of Open Access Journals (Sweden)

    Cacilda Joyce Ferreira da Silva Garcia

    Full Text Available OBJETIVOS: Verificar a posssibilidade de quantificar a expressão dos marcadores tumorais CD-34 e Fator VIII no câncer de cólon; verificar se existe superioridade entre um marcador e outro para estudo da angiogênese; verificar se há correlação na análise do índice de marcagem e a densidade óptica média nos marcadores utilizados. MÉTODOS: Dezessete casos de adenocarcinoma colorretal recuperados de blocos de parafina e confirmados pela hematoxilina-eosina, foram submetidos à coloração imunoistoquímica pelo método da estreptoavidina-biotina-peroxidase e utilizados os marcadores tumorais CD-34 e Fator VIII. Após este processo as lâminas foram submetidas à leitura no sistema Samba 4000® e avaliadas pelo software Immuno®. Os parâmetros estudados foram: índice de marcagem e densidade óptica, expressos por médias, medianas, valores mínimos, valores máximos e desvios-padrão, analisados estatisticamente. RESULTADOS: Para o marcador CD-34 não houve normalidade dos dados em relação ao índice de marcagem e houve para a densidade óptica. Para o Fator VIII, houve normalidade de dados em relação ao índice de marcagem e para a densidade óptica. CONCLUSÃO: Foi possível quantificar a expressão dos marcadores tumorais CD-34 e Fator VIII através do índice de marcagem e da densidade óptica média; não houve diferença entre os marcadores em relação à média do índice de marcagem e da densidade óptica, não sendo possível definir superioridade entre um e outro; não foi observada tendência à correlação quando comparados densidade óptica e índice de marcagem do Fator VIII e do CD-34 isoladamente estudados; não houve correlação entre o índice de marcagem do Fator VIII quando comparado com o CD-34, bem como a densidade óptica do Fator VIII com o CD-34.

  14. Global Precipitation Measurement Mission: Architecture and Mission Concept (United States)

    Bundas, David


    The Global Precipitation Measurement (GPM) Mission is a collaboration between the National Aeronautics and Space Administration (NASA) and the Japanese Aerospace Exploration Agency (JAXA), and other partners, with the goal of monitoring the diurnal and seasonal variations in precipitation over the surface of the earth. These measurements will be used to improve current climate models and weather forecasting, and enable improved storm and flood warnings. This paper gives an overview of the mission architecture and addresses some of the key trades that have been completed, including the selection of the Core Observatory s orbit, orbit maintenance trades, and design issues related to meeting orbital debris requirements.

  15. Separation method for ions of elements of the III., IV., VI. and VIII. groups of periodical system

    International Nuclear Information System (INIS)

    Marhol, M.


    The method is presented of separating the ions of the elements of the periodic system groups III, IV, and VIII by ion exchangers. The ions are complex-bonded to a new type of ion exchanger consisting of the polycondensates of phenol with aldehydes or ketones and containing an atom of phosphorus, arsenic or antimony with an atom of sulphur or oxygen in a complex bond. The polymers of compounds containing a double bond, e.g., of butadiene, polyvinyl alcohol, polyethylene, polypropylene, and the compounds of styrene with fural may also be used for this purpose. The method is demonstrated on a case of uranium and heavy metal concentration and the separation thereof from waste waters. (L.K.)

  16. VIII Spanish meeting on statistical physics: Proceeding of the Meeting held at Universidad Carlos III de Madrid

    International Nuclear Information System (INIS)

    Cuesta, J.A.; Sanchez, A.


    This book contains the Proceedings of ''Fisica Estadistica'97'' (FisEs'97, VIII Spanish Meeting on Statistical Physics), held at the Campus of Getafe (Madrid, Spain) of the Universidad Carlos III de Madrid on September 25 through 27, 1997. Although this is the first time the Proceedings of a Meeting in this series are published, ''Fisica Estasdistica'' dates back to 1986, when about fifty Spanish scientists attended the first edition in Barcelona. That first Meeting was organized by a group of young and not so young physicists who wanted to set up a national conference of an international level and with a broader, more interdisciplinary scope than others held at that time. Their idea quickly got off the ground and following the first edition, sequels took place every year and a half: Palma de Mallorca (1988), Badajoz (1990), Cabuenas, Asturies (1991), El Escorial, Madrid (1993), Sevilla (1994), and Zaragoza (1996)

  17. Proceedings of XIV Workshop on Nuclear Physics. VIII International Symposium on Nuclear and Related Techniques. WONP-NURT 2013

    International Nuclear Information System (INIS)


    This year 2013, the XIV Workshop on Nuclear Physics and VIII International Symposium on Nuclear and Related Techniques, WONP-NURT 2013 organized by the Center of Technological Applications and Nuclear Development from 5 to 8 February at the National Museum of Fine Arts. NURT is one of the key Cuban scientific meetings since 1997 dealing with the peaceful applications of nuclear techniques in several domains of the society. WONP and NURT provide an unique opportunity for the national and international scientific community to meet outstanding researchers and discuss current trends in several areas of theoretical, experimental and applied nuclear physics and related topics. The papers submitted to this event are presented in this CD-ROM


    Directory of Open Access Journals (Sweden)

    Wawan Suseno


    Berdasarkan pengalaman mengajar di SMPN 01 Bang Haji, ternyata masih banyak yang mengalami kesulitan dalam memahami persamaan linear dua variabel. Penelitian ini bertujuan untuk meningkatkan hasil belajar siswa dan keaktifan siswa belajar di dalam kelas. Jenis penelitian ini adalah penelitian tindakan kelas (PTK dengan dua siklus, siklus I terdiri atas 9 pertemuan, dan siklus II 6 pertemuan. Subjek penelitian adalah 24 orang siswa kelas VIII, 6 orang laki-laki, dan 18 orang perempuan. Kegiatan penelitian pada tanggal 16 Januari sampai 17 Maret 2017. Kegiatan pembelajaran dengan menerapkan pembelajaran kooperatif tipe TGT. Hasil penelitian menunjukkan bahwa penerapan pembelajaran kooperatif tipe TGT telah terlaksana dengan sangat baik, keaktifan belajar siswa yang diperoleh dari hasil observasi dan angket berada pada kategori tinggi dan baik, hasil belajar siswa mencapai 87,5 % dan telah mencapai nilai ≥ 70.

  19. Thrombomodulin as a marker for vascular tumors. Comparative study with factor VIII and Ulex europaeus I lectin. (United States)

    Yonezawa, S; Maruyama, I; Sakae, K; Igata, A; Majerus, P W; Sato, E


    Thrombomodulin (TM) is a newly described endothelial cell-associated protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. Various vascular tumors were characterized with immunoperoxidase staining with the use of a polyclonal anti-TM serum. The staining patterns of TM were compared with those of Factor VIII-related antigen (FVIII-RAG) and Ulex europaeus agglutinin-I (UEA-I), which have been used as markers for endothelial cells. The results showed that TM is a specific and a highly sensitive marker for angiosarcomas in comparison with FVIII-RAG or UEA-I. In contrast, UEA-I is more sensitive for benign vascular tumors than TM or FVIII-RAG. The other mesenchymal tumors of nonvascular origin showed negative staining for three endothelial markers. These results indicate that TM is a new specific and sensitive tool for the diagnosis of angiosarcomas.

  20. Joint bleeds increase the inhibitor response to human factor VIII in a rat model of severe haemophilia A

    DEFF Research Database (Denmark)

    Löfgren, Karin Maria; Søndergaard, H.; Skov, Søren


    Introduction The most serious complication in haemophilia A (HA) replacement therapy with coagulation factor VIII (FVIII) is neutralizing antibodies, i.e. inhibitors. It has been hypothesized that danger signals generated during a bleed might have an adjuvant effect on the immune response to FVIII...... in on-demand treatment, increasing the inhibitor risk. Aim To compare the antibody response to treatment with recombinant human FVIII (rhFVIII) in relation to induced knee joint bleeds and treatment without concurrent bleeds in a HA rat model. Method HA rats were divided into two groups: one group (n...... = 10) receiving three needle induced knee joint bleeds 14 days apart and a control group (n = 9) receiving three sham procedures. Three hours after each injury/sham 50 IU kg−1 rhFVIII was administrated intravenously. Subsequently, both groups continued rhFVIII treatment for another 9 weeks. Binding...

  1. Ramsay Hunt syndrome with unilateral polyneuropathy involving cranial nerves V, VII, VIII, and XII in a diabetic patient. (United States)

    Sun, Wei-Lian; Yan, Jian-Liang; Chen, Li-Li


    Ramsay Hunt syndrome is a rare complication of the varicella zoster virus, defined as a peripheral facial palsy that typically results from involvement of the facial and auditory nerves. Ramsay Hunt syndrome can be associated with cranial nerves V, VI, IX, and X but rarely with XII. We describe an atypical case of Ramsay Hunt syndrome with multiple cranial nerve involvement of nerves V, VII, VIII, and XII. Antiviral drugs, antibiotics, insulin, and traditional Chinese drugs were administered immediately after admission. After 3 months of combination therapy, the patient had recovered satisfactorily. Herpes zoster can cause severe infections in diabetic patients and should be treated as soon after detection as possible. Ramsay Hunt syndrome should be recognized as a polycranial neuritis characterized by damage to sensory and motor nerves. In addition to facial and vestibular nerve paralysis, Ramsay Hunt syndrome may also involve cranial nerves V and XII.

  2. Short-range order in alloys of nickel with the elements of group VIII of the periodic table

    International Nuclear Information System (INIS)

    Khwaja, F.A.


    Experimental measurements of the diffuse X-ray scattering intensity were performed on alloys of Ni with Rh and Os. The atomic short-range order (SRO) parameters αsub(i) and the size-effect parameters βsub(i) were calculated from these measurements. It is established that SRO and size-effect exist in Ni-Rh and Ni-Os alloys analogously as in a few other alloys of Ni with the elements of group VIII of the periodic table. The experimental data was interpreted theoretically by calculating the interaction energies from the pseudo-potentials and the effective valencies of the individual components of the systems studied. It was found that theoretically calculated values of the interaction energies for these alloys are inconsistent with the experimentally determined sign of the SRO parameter. (author)

  3. The Safety and Feasibility of Three-Dimensional Visualization Technology Assisted Right Posterior Lobe Allied with Part of V and VIII Sectionectomy for Right Hepatic Malignancy Therapy. (United States)

    Hu, Min; Hu, Haoyu; Cai, Wei; Mo, Zhikang; Xiang, Nan; Yang, Jian; Fang, Chihua


    Hepatectomy is the optimal method for liver cancer; the virtual liver resection based on three-dimensional visualization technology (3-DVT) could provide better preoperative strategy for surgeon. We aim to introduce right posterior lobe allied with part of V and VIII sectionectomy assisted by 3-DVT as a promising treatment for massive or multiple right hepatic malignancies to retain maximum residual liver volume on the basis of R0 resection. Among 126 consecutive patients who underwent hepatectomy, 9 (7%) underwent right posterior lobe allied with part of V and VIII sectionectomy. 21 (17%) underwent right hemihepatectomy (RH). The virtual RH was performed with 3-DVT, which provided better observation of spatial position relationship between tumor and vessels, and the more accurate estimation of the remnant liver volume. If remnant liver volume was right posterior lobe allied with part of V and VIII sectionectomy should be undergone. Then, the precut line ought to be planned on the basis of protecting the portal branch of subsegment 5 and 8. The postoperative outcome of patients was compared before and after propensity score matching. Nine patients meeting the eligibility criteria received right posterior lobe allied with part of V and VIII sectionectomy. The variables, including the overall mean operation time, blood transfusion, operation length, liver function, and postoperative complications, were similar between two groups before and after propensity matching. The postoperative first, third, fifth, and seventh days mean value of aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin (ALB), and total bilirubin had no significant difference compared with preoperative value. One patient in each group had recurrence six months after surgery. Right posterior lobe allied with part of V and VIII sectionectomy based on 3-DVT is safe and feasible surgery way, and can be a very promising method in massive or multiple right hepatic malignancy therapy.

  4. Targeting factor VIII expression to platelets for hemophilia A gene therapy does not induce an apparent thrombotic risk in mice. (United States)

    Baumgartner, C K; Mattson, J G; Weiler, H; Shi, Q; Montgomery, R R


    Essentials Platelet-Factor (F) VIII gene therapy is a promising treatment in hemophilia A. This study aims to evaluate if platelet-FVIII expression would increase the risk for thrombosis. Targeting FVIII expression to platelets does not induce or elevate thrombosis risk. Platelets expressing FVIII are neither hyper-activated nor hyper-responsive. Background Targeting factor (F) VIII expression to platelets is a promising gene therapy approach for hemophilia A, and is successful even in the presence of inhibitors. It is well known that platelets play important roles not only in hemostasis, but also in thrombosis and inflammation. Objective To evaluate whether platelet-FVIII expression might increase thrombotic risk and thereby compromise the safety of this approach. Methods In this study, platelet-FVIII-expressing transgenic mice were examined either in steady-state conditions or under prothrombotic conditions induced by inflammation or the FV Leiden mutation. Native whole blood thrombin generation assay, rotational thromboelastometry analysis and ferric chloride-induced vessel injury were used to evaluate the hemostatic properties. Various parameters associated with thrombosis risk, including D-dimer, thrombin-antithrombin complexes, fibrinogen, tissue fibrin deposition, platelet activation status and activatability, and platelet-leukocyte aggregates, were assessed. Results We generated a new line of transgenic mice that expressed 30-fold higher levels of platelet-expressed FVIII than are therapeutically required to restore hemostasis in hemophilic mice. Under both steady-state conditions and prothrombotic conditions induced by lipopolysaccharide-mediated inflammation or the FV Leiden mutation, supratherapeutic levels of platelet-expressed FVIII did not appear to be thrombogenic. Furthermore, FVIII-expressing platelets were neither hyperactivated nor hyperactivatable upon agonist activation. Conclusion We conclude that, in mice, more than 30-fold higher levels of

  5. Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice.

    Directory of Open Access Journals (Sweden)

    Marina E Fomin

    Full Text Available Liver sinusoidal endothelial cells (LSECs form a semi-permeable barrier between parenchymal hepatocytes and the blood. LSECs participate in liver metabolism, clearance of pathological agents, immunological responses, architectural maintenance of the liver and synthesis of growth factors and cytokines. LSECs also play an important role in coagulation through the synthesis of Factor VIII (FVIII. Herein, we phenotypically define human LSECs isolated from fetal liver using flow cytometry and immunofluorescence microscopy. Isolated LSECs were cultured and shown to express endothelial markers and markers specific for the LSEC lineage. LSECs were also shown to engraft the liver when human fetal liver cells were transplanted into immunodeficient mice with liver specific expression of the urokinase-type plasminogen activator (uPA transgene (uPA-NOG mice. Engrafted cells expressed human Factor VIII at levels approaching those found in human plasma. We also demonstrate engraftment of adult LSECs, as well as hepatocytes, transplanted into uPA-NOG mice. We propose that overexpression of uPA provides beneficial conditions for LSEC engraftment due to elevated expression of the angiogenic cytokine, vascular endothelial growth factor. This work provides a detailed characterization of human midgestation LSECs, thereby providing the means for their purification and culture based on their expression of CD14 and CD32 as well as a lack of CD45 expression. The uPA-NOG mouse is shown to be a permissive host for human LSECs and adult hepatocytes, but not fetal hepatoblasts. Thus, these mice provide a useful model system to study these cell types in vivo. Demonstration of human FVIII production by transplanted LSECs encourages further pursuit of LSEC transplantation as a cellular therapy for the treatment of hemophilia A.

  6. Characterization of a thrombin cleavage site mutation (Arg 1689 to Cys) in the factor VIII gene of two unrelated patients with cross-reacting material-positive hemophilia A. (United States)

    Arai, M; Higuchi, M; Antonarakis, S E; Kazazian, H H; Phillips, J A; Janco, R L; Hoyer, L W


    The molecular defect responsible for moderate and severe hemophilia A has been identified for two unrelated patients with the CRM-positive form of this disorder (factor VIII activity of 0.02 and 0.05 U/mL with factor VIII antigen of 0.87 and 2.20 U/mL). In both cases, the immunopurified dysfunctional factor VIII protein is abnormal, in that the 80 Kd light chain is not cleaved by thrombin at arginine-1689. The basis for this failure was identified by polymerase chain reaction amplification of exon 14 of the variant factor VIII genes and direct sequencing of the amplified products. In both cases, a single base substitution (C to T) was identified that produces an arginine to cysteine substitution at amino acid residue 1689. These data identify the molecular defects of the two identical factor VIII variant proteins. The dysfunctional factor VIII has been designated "Factor VIII-East Hartford," the residence of the patient in whom the defect was first identified.

  7. Effects of Mg/Ga and V/III source ratios on hole concentration of N-polar (000\\bar{1}) p-type GaN grown by metalorganic vapor phase epitaxy (United States)

    Nonoda, Ryohei; Shojiki, Kanako; Tanikawa, Tomoyuki; Kuboya, Shigeyuki; Katayama, Ryuji; Matsuoka, Takashi


    The effects of growth conditions such as Mg/Ga and V/III ratios on the properties of N-polar (000\\bar{1}) p-type GaN grown by metalorganic vapor phase epitaxy were studied. Photoluminescence spectra from Mg-doped GaN depended on Mg/Ga and V/III ratios. For the lightly doped samples, the band-to-acceptor emission was observed at 3.3 eV and its relative intensity decreased with increasing V/III ratio. For the heavily doped samples, the donor-acceptor pair emission was observed at 2.8 eV and its peak intensity monotonically decreased with V/III ratio. The hole concentration was maximum for the Mg/Ga ratio. This is the same tendency as in group-III polar (0001) growth. The V/III ratio also reduced the hole concentration. The higher V/III ratio reduced the concentration of residual donors such as oxygen by substituting nitrogen atoms. The surface became rougher with increasing V/III ratio and the hillock density increased.

  8. Resumes of the Bird mission (United States)

    Lorenz, E.; Borwald, W.; Briess, K.; Kayal, H.; Schneller, M.; Wuensten, Herbert


    The DLR micro satellite BIRD (Bi-spectral Infra Red Detection) was piggy- back launched with the Indian Polar Satellite Launch Vehicle PSLV-C3 into a 570 km circular sun-synchronous orbit on 22 October 2001. The BIRD mission, fully funded by the DLR, answers topical technological and scientific questions related to the operation of a compact infra- red push-broom sensor system on board of a micro satellite and demonstrates new spacecraft bus technologies. BIRD mission control is conducted by DLR / GSOC in Oberpfaffenhofen. Commanding, data reception and data processing is performed via ground stations in Weilheim and Neustrelitz (Germany). The BIRD mission is a demonstrator for small satellite projects dedicated to the hazard detection and monitoring. In the year 2003 BIRD has been used in the ESA project FUEGOSAT to demonstrate the utilisation of innovative space technologies for fire risk management.

  9. 308 Building deactivation mission analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.


    This report presents the results of the 308 Building (Fuels Development Laboratory) Deactivation Project mission analysis. Hanford systems engineering (SE) procedures call for a mission analysis. The mission analysis is an important first step in the SE process. The functions and requirements to successfully accomplish this mission, the selected alternatives and products will later be defined using the SE process

  10. 309 Building deactivation mission analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.


    This report presents the results of the 309 Building (Plutonium Fuels Utilization Program) Deactivation Project mission analysis. Hanford systems engineering (SE) procedures call for a mission analysis. The mission analysis is an important first step in the SE process. The functions and requirements to successfully accomplish this mission, the selected alternatives and products will later be defined using the SE process

  11. MIOSAT Mission Scenario and Design (United States)

    Agostara, C.; Dionisio, C.; Sgroi, G.; di Salvo, A.


    MIOSAT ("Mssione Ottica su microSATellite") is a low-cost technological / scientific microsatellite mission for Earth Observation, funded by Italian Space Agency (ASI) and managed by a Group Agreement between Rheinmetall Italia - B.U. Spazio - Contraves as leader and Carlo Gavazzi Space as satellite manufacturer. Several others Italians Companies, SME and Universities are involved in the development team with crucial roles. MIOSAT is a microsatellite weighting around 120 kg and placed in a 525 km altitude sun-synchronuos circular LEO orbit. The microsatellite embarks three innovative optical payloads: Sagnac multi spectral radiometer (IFAC-CNR), Mach Zehender spectrometer (IMM-CNR), high resolution pancromatic camera (Selex Galileo). In addition three technological experiments will be tested in-flight. The first one is an heat pipe based on Marangoni effect with high efficiency. The second is a high accuracy Sun Sensor using COTS components and the last is a GNSS SW receiver that utilizes a Leon2 processor. Finally a new generation of 28% efficiency solar cells will be adopted for the power generation. The platform is highly agile and can tilt along and cross flight direction. The pointing accuracy is in the order of 0,1° for each axe. The pointing determination during images acquisition is <0,02° for the axis normal to the boresight and 0,04° for the boresight. This paper deals with MIOSAT mission scenario and definition, highlighting trade-offs for mission implementation. MIOSAT mission design has been constrained from challenging requirements in terms of satellite mass, mission lifetime, instrument performance, that have implied the utilization of satellite agility capability to improve instruments performance in terms of S/N and resolution. The instruments provide complementary measurements that can be combined in effective ways to exploit new applications in the fields of atmosphere composition analysis, Earth emissions, antropic phenomena, etc. The Mission

  12. The inner magnetosphere imager mission

    International Nuclear Information System (INIS)

    Johnson, L.; Herrmann, M.


    After 30 years of in situ measurements of the Earth's magnetosphere, scientists have assembled an incomplete picture of its global composition and dynamics. Imaging the magnetosphere from space will enable scientists to better understand the global shape of the inner magnetosphere, its components and processes. The proposed inner magnetosphere imager (IMI) mission will obtain the first simultaneous images of the component regions of the inner magnetosphere and will enable scientists to relate these global images to internal and external influences as well as local observations. To obtain simultaneous images of component regions of the inner magnetosphere, measurements will comprise: the ring current and inner plasma sheet using energetic neutral atoms; the plasmasphere using extreme ultraviolet; the electron and proton auroras using far ultraviolet (FUV) and x rays; and the geocorona using FUV. The George C. Marshall Space Flight Center (MSFC) is performing a concept definition study of the proposed mission. NASA's Office of Space Science and Applications has placed the IMI third in its queue of intermediate-class missions for launch in the 1990's. An instrument complement of approximately seven imagers will fly in an elliptical Earth orbit with a seven Earth Radii (R E ) altitude apogee and approximately 4,800-kin altitude perigee. Several spacecraft concepts were examined for the mission. The first concept utilizes a spinning spacecraft with a despun platform. The second concept splits the instruments onto a spin-stabilized spacecraft and a complementary three-axis stabilized spacecraft. Launch options being assessed for the spacecraft range from a Delta 11 for the single and dual spacecraft concepts to dual Taurus launches for the two smaller spacecraft. This paper will address the mission objectives, the spacecraft design considerations, the results of the MSFC concept definition study, and future mission plans

  13. Cyberinfrastructure for Aircraft Mission Support (United States)

    Freudinger, Lawrence C.


    Forth last several years NASA's Airborne Science Program has been developing and using infrastructure and applications that enable researchers to interact with each other and with airborne instruments via network communications. Use of these tools has increased near realtime situational awareness during field operations, resulting it productivity improvements, improved decision making, and the collection of better data. Advances in pre-mission planning and post-mission access have also emerged. Integrating these capabilities with other tools to evolve coherent service-oriented enterprise architecture for aircraft flight and test operations is the subject of ongoing efforts.

  14. NASA Facts, The Viking Mission. (United States)

    National Aeronautics and Space Administration, Washington, DC. Educational Programs Div.

    Presented is one of a series of publications of National Aeronautics and Space Administration (NASA) facts about the exploration of Mars. The Viking mission to Mars, consisting of two unmanned NASA spacecraft launched in August and September, 1975, is described. A description of the spacecraft and their paths is given. A diagram identifying the…

  15. 75 FR 6178 - Mission Statement (United States)


    ... geothermal, biomass, hydropower, wind, solar, and energy efficiency sectors. The mission will focus on... offers potential growth, barriers still exist that prevent U.S. companies from accessing the market and... additional opportunities in solar, biomass, ``clean coal'' technology such as gasification or wet coal...

  16. The Europa Ocean Discovery mission

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, B.C. [Los Alamos National Lab., NM (United States); Chyba, C.F. [Univ. of Arizona, Tucson, AZ (United States); Abshire, J.B. [National Aeronautics and Space Administration, Greenbelt, MD (United States). Goddard Space Flight Center] [and others


    Since it was first proposed that tidal heating of Europa by Jupiter might lead to liquid water oceans below Europa`s ice cover, there has been speculation over the possible exobiological implications of such an ocean. Liquid water is the essential ingredient for life as it is known, and the existence of a second water ocean in the Solar System would be of paramount importance for seeking the origin and existence of life beyond Earth. The authors present here a Discovery-class mission concept (Europa Ocean Discovery) to determine the existence of a liquid water ocean on Europa and to characterize Europa`s surface structure. The technical goal of the Europa Ocean Discovery mission is to study Europa with an orbiting spacecraft. This goal is challenging but entirely feasible within the Discovery envelope. There are four key challenges: entering Europan orbit, generating power, surviving long enough in the radiation environment to return valuable science, and complete the mission within the Discovery program`s launch vehicle and budget constraints. The authors will present here a viable mission that meets these challenges.

  17. Deep Space Gateway "Recycler" Mission (United States)

    Graham, L.; Fries, M.; Hamilton, J.; Landis, R.; John, K.; O'Hara, W.


    Use of the Deep Space Gateway provides a hub for a reusable planetary sample return vehicle for missions to gather star dust as well as samples from various parts of the solar system including main belt asteroids, near-Earth asteroids, and Mars moon.

  18. Canada and Missions for Peace

    International Development Research Centre (IDRC) Digital Library (Canada)

    The study focuses primarily on Canada's role in these missions in light of ..... simply because peacekeeping has been the chief form of UN intervention and one in which ... Other factors, such as financial constraints and increasing social problems ..... Luck, superior armaments, the shortage of professional officers among the ...

  19. The DEMETER Science Mission Centre

    Czech Academy of Sciences Publication Activity Database

    Lagoutte, D.; Brochot, J.; Y.; de Carvalho, D.; Elie, F.; Harivelo, F.; Hobara, Y.; Madrias, L.; Parrot, M.; Pincon, J. L.; Berthelier, J. J.; Peschard, D.; Seran, E.; Gangloff, M.; Sauvaud, J. A.; Lebreton, J. P.; Štverák, Štěpán; Trávníček, Pavel M.; Grygorczuk, J.; Slominski, J.; Wronowski, R.; Barbier, S.; Bernard, P.; Gaboriaud, A.; Wallut, J. M.


    Roč. 54, č. 5 (2006), s. 428-440 ISSN 0032-0633 Institutional research plan: CEZ:AV0Z30420517 Keywords : Mission Centre * Data processing Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 1.509, year: 2006

  20. Space nuclear tug mission applications

    International Nuclear Information System (INIS)

    Hodge, J.R.; Rauen, L.A.


    An initial assessment indicates that the NEBA-1 and NEBA-3 bimodal reactor designs can be integrated into a reusable tug which is capable of supporting many missions including GSO delivery, GSO retrieval, lunar trajectory deliveries, interplanetary deliveries, and a variety of satellite servicing. The tug close-quote s nuclear thermal propulsion provides timely transport and payload delivery, with GSO deliveries on the order of 3 endash 7 days. In general, the tug may provide a number of potential benefits to users. The tug may, for example, extend the life of an existing on-orbit spacecraft, boost spacecraft which were not delivered to their operational orbit, offer increased payload capability, or possibly allow payloads to launch on smaller less expensive launch vehicles. Reusing the tug for 5 or 10 missions requires total reactor burn times of 50 and 100 hours, respectively. Shielding, boom structure, and radiator requirements were identified as key factors in the configuration layout. Economic feasibility is still under evaluation, but preliminary estimates indicate that average flight costs may range from $32 M to $34 M for a 10-mission vehicle and from $39 M to $42 M for a 5-mission vehicle. copyright 1996 American Institute of Physics

  1. Catholic Higher Education as Mission (United States)

    Lowery, Daniel


    This article uses the work of Anthony J. Gittins to reframe our understanding of Catholic higher education as mission. The broad adoption of this framework would require a common intellectual foundation, the possibility of which is dismissed by many. An accessible ontology is implied, however, in the existential analysis and theology of Karl…

  2. The Europa Clipper Mission Concept (United States)

    Pappalardo, Robert; Goldstein, Barry; Magner, Thomas; Prockter, Louise; Senske, David; Paczkowski, Brian; Cooke, Brian; Vance, Steve; Wes Patterson, G.; Craft, Kate


    A NASA-appointed Science Definition Team (SDT), working closely with a technical team from the Jet Propulsion Laboratory (JPL) and the Applied Physics Laboratory (APL), recently considered options for a future strategic mission to Europa, with the stated science goal: Explore Europa to investigate its habitability. The group considered several mission options, which were fully technically developed, then costed and reviewed by technical review boards and planetary science community groups. There was strong convergence on a favored architecture consisting of a spacecraft in Jupiter orbit making many close flybys of Europa, concentrating on remote sensing to explore the moon. Innovative mission design would use gravitational perturbations of the spacecraft trajectory to permit flybys at a wide variety of latitudes and longitudes, enabling globally distributed regional coverage of the moon's surface, with nominally 45 close flybys at altitudes from 25 to 100 km. We will present the science and reconnaissance goals and objectives, a mission design overview, and the notional spacecraft for this concept, which has become known as the Europa Clipper. The Europa Clipper concept provides a cost-efficient means to explore Europa and investigate its habitability, through understanding the satellite's ice and ocean, composition, and geology. The set of investigations derived from the Europa Clipper science objectives traces to a notional payload for science, consisting of: Ice Penetrating Radar (for sounding of ice-water interfaces within and beneath the ice shell), Topographical Imager (for stereo imaging of the surface), ShortWave Infrared Spectrometer (for surface composition), Neutral Mass Spectrometer (for atmospheric composition), Magnetometer and Langmuir Probes (for inferring the satellite's induction field to characterize an ocean), and Gravity Science (to confirm an ocean).The mission would also include the capability to perform reconnaissance for a future lander

  3. The EXIST Mission Concept Study (United States)

    Fishman, Gerald J.; Grindlay, J.; Hong, J.


    EXIST is a mission designed to find and study black holes (BHs) over a wide range of environments and masses, including: 1) BHs accreting from binary companions or dense molecular clouds throughout our Galaxy and the Local Group, 2) supermassive black holes (SMBHs) lying dormant in galaxies that reveal their existence by disrupting passing stars, and 3) SMBHs that are hidden from our view at lower energies due to obscuration by the gas that they accrete. 4) the birth of stellar mass BHs which is accompanied by long cosmic gamma-ray bursts (GRBs) which are seen several times a day and may be associated with the earliest stars to form in the Universe. EXIST will provide an order of magnitude increase in sensitivity and angular resolution as well as greater spectral resolution and bandwidth compared with earlier hard X-ray survey telescopes. With an onboard optical-infra red (IR) telescope, EXIST will measure the spectra and redshifts of GRBs and their utility as cosmological probes of the highest z universe and epoch of reionization. The mission would retain its primary goal of being the Black Hole Finder Probe in the Beyond Einstein Program. However, the new design for EXIST proposed to be studied here represents a significant advance from its previous incarnation as presented to BEPAC. The mission is now less than half the total mass, would be launched on the smallest EELV available (Atlas V-401) for a Medium Class mission, and most importantly includes a two-telescope complement that is ideally suited for the study of both obscured and very distant BHs. EXIST retains its very wide field hard X-ray imaging High Energy Telescope (HET) as the primary instrument, now with improved angular and spectral resolution, and in a more compact payload that allows occasional rapid slews for immediate optical/IR imaging and spectra of GRBs and AGN as well as enhanced hard X-ray spectra and timing with pointed observations. The mission would conduct a 2 year full sky survey in

  4. IntroductionThe Cluster mission

    Directory of Open Access Journals (Sweden)

    M. Fehringer

    Full Text Available The Cluster mission, ESA’s first cornerstone project, together with the SOHO mission, dating back to the first proposals in 1982, was finally launched in the summer of 2000. On 16 July and 9 August, respectively, two Russian Soyuz rockets blasted off from the Russian cosmodrome in Baikonour to deliver two Cluster spacecraft, each into their proper orbit. By the end of August 2000, the four Cluster satellites had reached their final tetrahedral constellation. The commissioning of 44 instruments, both individually and as an ensemble of complementary tools, was completed five months later to ensure the optimal use of their combined observational potential. On 1 February 2001, the mission was declared operational. The main goal of the Cluster mission is to study the small-scale plasma structures in three dimensions in key plasma regions, such as the solar wind, bow shock, magnetopause, polar cusps, magnetotail and the auroral zones. With its unique capabilities of three-dimensional spatial resolution, Cluster plays a major role in the International Solar Terrestrial Program (ISTP, where Cluster and the Solar and Heliospheric Observatory (SOHO are the European contributions. Cluster’s payload consists of state-of-the-art plasma instrumentation to measure electric and magnetic fields from the quasi-static up to high frequencies, and electron and ion distribution functions from energies of nearly 0 eV to a few MeV. The science operations are coordinated by the Joint Science Operations Centre (JSOC, at the Rutherford Appleton Laboratory (UK, and implemented by the European Space Operations Centre (ESOC, in Darmstadt, Germany. A network of eight national data centres has been set up for raw data processing, for the production of physical parameters, and their distribution to end users all over the world. The latest information on the Cluster mission can be found at

  5. Swarm: ESA's Magnetic Field Mission (United States)

    Plank, G.; Floberghagen, R.; Menard, Y.; Haagmans, R.


    Swarm is the fifth Earth Explorer mission in ESA's Living Planet Programme, and is scheduled for launch in fall 2013. The objective of the Swarm mission is to provide the best-ever survey of the geomagnetic field and its temporal evolution using a constellation of three identical satellites. The mission shall deliver data that allow access to new insights into the Earth system by improved scientific understanding of the Earth's interior and near-Earth electromagnetic environment. After launch and triple satellite release at an initial altitude of about 490 km, a pair of the satellites will fly side-by-side with slowly decaying altitude, while the third satellite will be lifted to 530 km to complete the Swarm constellation. High-precision and high-resolution measurements of the strength, direction and variation of the magnetic field, complemented by precise navigation, accelerometer and electric field measurements, will provide the observations required to separate and model various sources of the geomagnetic field and near-Earth current systems. The mission science goals are to provide a unique view into Earth's core dynamics, mantle conductivity, crustal magnetisation, ionospheric and magnetospheric current systems and upper atmosphere dynamics - ranging from understanding the geodynamo to contributing to space weather. The scientific objectives and results from recent scientific studies will be presented. In addition the current status of the project, which is presently in the final stage of the development phase, will be addressed. A consortium of European scientific institutes is developing a distributed processing system to produce geophysical (Level 2) data products for the Swarm user community. The setup of the Swarm ground segment and the contents of the data products will be addressed. In case the Swarm satellites are already in orbit, a summary of the on-going mission operations activities will be given. More information on Swarm can be found at

  6. IntroductionThe Cluster mission

    Directory of Open Access Journals (Sweden)

    C. P. Escoubet


    Full Text Available The Cluster mission, ESA’s first cornerstone project, together with the SOHO mission, dating back to the first proposals in 1982, was finally launched in the summer of 2000. On 16 July and 9 August, respectively, two Russian Soyuz rockets blasted off from the Russian cosmodrome in Baikonour to deliver two Cluster spacecraft, each into their proper orbit. By the end of August 2000, the four Cluster satellites had reached their final tetrahedral constellation. The commissioning of 44 instruments, both individually and as an ensemble of complementary tools, was completed five months later to ensure the optimal use of their combined observational potential. On 1 February 2001, the mission was declared operational. The main goal of the Cluster mission is to study the small-scale plasma structures in three dimensions in key plasma regions, such as the solar wind, bow shock, magnetopause, polar cusps, magnetotail and the auroral zones. With its unique capabilities of three-dimensional spatial resolution, Cluster plays a major role in the International Solar Terrestrial Program (ISTP, where Cluster and the Solar and Heliospheric Observatory (SOHO are the European contributions. Cluster’s payload consists of state-of-the-art plasma instrumentation to measure electric and magnetic fields from the quasi-static up to high frequencies, and electron and ion distribution functions from energies of nearly 0 eV to a few MeV. The science operations are coordinated by the Joint Science Operations Centre (JSOC, at the Rutherford Appleton Laboratory (UK, and implemented by the European Space Operations Centre (ESOC, in Darmstadt, Germany. A network of eight national data centres has been set up for raw data processing, for the production of physical parameters, and their distribution to end users all over the world. The latest information on the Cluster mission can be found at

  7. [Methods of investigation in clinical cardiology. VIII. Socioeconomic evaluation of clinical cardiology practice]. (United States)

    Lázaro de Mercado, P


    Health services are systems whose mission is to improve the health status of both individuals and society in general. In recent decades, these systems have faced challenges such as their increasing complexity, limited resources, rapid innovation and diffusion of medical technologies, pressures on demand from society and professionals, and the lack of knowledge of the effects of these factors on costs and society's health. In addition, health care expenditures have grown twice as fast as wealth in industrialized countries during the last 25 years. These problems have prompted cost containment as a key issue in health policy and, at the same time, have promoted the development of socioeconomic evaluation as a scientific activity in the frame of health services research. Socioeconomic evaluation tries to determine if the sacrifice made by society, which devotes part of its limited resources to health care, maximizes the outcomes for population. This article describes basic concepts and methods of economic appraisal in health services which are illustrated with examples of clinical practice in cardiology. Common methods of evaluation are described; the relation between the clinical outcome of a procedure and its associated costs is emphasized in explaining the types of efficiency analysis (cost-efficacy, cost-effectiveness, cost-utility, and cost-benefit); and finally a guide for socioeconomic evaluation is provided.

  8. Planck 2015 results. VIII. High Frequency Instrument data processing: Calibration and maps

    CERN Document Server

    Adam, R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A.J.; Barreiro, R.B.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bertincourt, B.; Bielewicz, P.; Bock, J.J.; Bonavera, L.; Bond, J.R.; Borrill, J.; Bouchet, F.R.; Boulanger, F.; Bucher, M.; Burigana, C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, H.C.; Christensen, P.R.; Clements, D.L.; Colombi, S.; Colombo, L.P.L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B.P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R.D.; Davis, R.J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.-M.; Désert, F.-X.; Diego, J.M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T.A.; Eriksen, H.K.; Falgarone, E.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A.A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Ghosh, T.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K.M.; Gratton, S.; Gruppuso, A.; Gudmundsson, J.E.; Hansen, F.K.; Hanson, D.; Harrison, D.L.; Henrot-Versillé, S.; Herranz, D.; Hildebrandt, S.R.; Hivon, E.; Hobson, M.; Holmes, W.A.; Hornstrup, A.; Hovest, W.; Huffenberger, K.M.; Hurier, G.; Jaffe, A.H.; Jaffe, T.R.; Jones, W.C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T.S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C.R.; Le Jeune, M.; Leahy, J.P.; Lellouch, E.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P.B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P.M.; Macías-Pérez, J.F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P.G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Moreno, R.; Morgante, G.; Mortlock, D.; Moss, A.; Mottet, S.; Munshi, D.; Murphy, J.A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C.B.; Nørgaard-Nielsen, H.U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C.A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Pearson, T.J.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Pratt, G.W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J.P.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rusholme, B.; Sandri, M.; Santos, D.; Sauvé, A.; Savelainen, M.; Savini, G.; Scott, D.; Seiffert, M.D.; Shellard, E.P.S.; Spencer, L.D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J.A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vibert, L.; Vielva, P.; Villa, F.; Wade, L.A.; Wandelt, B.D.; Watson, R.; Wehus, I.K.; Yvon, D.; Zacchei, A.


    This paper describes the processing applied to the Planck High Frequency Instrument (HFI) cleaned, time-ordered information to produce photometrically calibrated maps in temperature and (for the first time) in polarization. The data from the 2.5 year full mission include almost five independent full-sky surveys. HFI observes the sky over a broad range of frequencies, from 100 to 857 GHz. To get the best accuracy on the calibration over such a large range, two different photometric calibration schemes have been used. The 545 and 857 GHz data are calibrated using models of planetary atmospheric emission. The lower frequencies (from 100 to 353 GHz) are calibrated using the time-variable cosmological microwave background dipole which we call the orbital dipole. This source of calibration only depends on the satellite velocity with respect to the solar system and permits an independent measurement of the amplitude of the CMB solar dipole (3364.5 +/- 0.8 \\mu K) which is 1\\sigma\\ higher than the WMAP measurement wit...

  9. Insight into resistance mechanism of anaplastic lymphoma kinase to alectinib and JH-VIII-157-02 caused by G1202R solvent front mutation

    Directory of Open Access Journals (Sweden)

    Wang H


    Full Text Available Han Wang,1–3 Yao Wang,1–3 Wentao Guo,4 Bin Du,1–3 Xiaobing Huang,1–3 Riping Wu,1–3 Baoyu Yang,1–3 Xiaoyan Lin,1–3,5 Yilan Wu6 1Department of Medical Oncology, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of China; 2Stem Cell Research Institute, Fujian Medical University, Fuzhou, People’s Republic of China; 3Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou, People’s Republic of China; 4School of Pharmacy, Wenzhou Medical University, Wenzhou, People’s Republic of China; 5Graduate School of Education, Fujian Medical University, Fuzhou, People’s Republic of China; 6School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, People’s Republic of China Background: Mutated anaplastic lymphoma kinase (ALK drives the development of advanced non-small cell lung cancer (NSCLC. Most reported small-molecule inhibitors targeting the ALK domain do not display good inhibition of the G1202R solvent front mutation. The solvent front mutation was assumed to hinder drug binding. However, a different fact could be uncovered by the simulations reported in this study through a structural analog of alectinib (JH-VIII-157-02, which demonstrated potent effects against the G1202R mutation. Methods: Molecular docking, conventional molecular dynamics (MD simulations, free energy calculations, and umbrella sampling (US simulations were carried out to make clear the principles of the binding preferences of alectinib and JH-VIII-157-02 toward ALKWT and the ALK G1202R (ALKG1202R mutation. Results: JH-VIII-157-02 has similar binding affinities to both ALKWT and ALKG1202R whereas it has has a much lower binding affinity for alectinib to ALKG1202R. Analysis of individual energy terms indicate the major variation involves the van der Waals and entropy terms. Structural analysis reveals that the conformational change of the ATP-binding glycine-rich loop was primarily responsible for the alectinib

  10. Mission analysis for the Martian Moons Explorer (MMX) mission (United States)

    Campagnola, Stefano; Yam, Chit Hong; Tsuda, Yuichi; Ogawa, Naoko; Kawakatsu, Yasuhiro


    Mars Moon eXplorer (MMX) is JAXA's next candidate flagship mission to be launched in the early 2020s. MMX will explore the Martian moons and return a sample from Phobos. This paper presents the mission analysis work, focusing on the transfer legs and comparing several architectures, such as hybrid options with chemical and electric propulsion modules. The selected baseline is a chemical-propulsion Phobos sample return, which is discussed in detail with the launch- and return-window analysis. The trajectories are optimized with the jTOP software, using planetary ephemerides for Mars and the Earth; Earth re-entry constraints are modeled with simple analytical equations. Finally, we introduce an analytical approximation of the three-burn capture strategy used in the Mars system. The approximation can be used together with a Lambert solver to quickly determine the transfer Δ v costs.

  11. Spacelab life sciences 2 post mission report (United States)

    Buckey, Jay C.


    Jay C. Buckey, M.D., Assistant Professor of Medicine at The University of Texas Southwestern Medical Center at Dallas served as an alternate payload specialist astronaut for the Spacelab Life Sciences 2 Space Shuttle Mission from January 1992 through December 1993. This report summarizes his opinions on the mission and offers suggestions in the areas of selection, training, simulations, baseline data collection and mission operations. The report recognizes the contributions of the commander, payload commander and mission management team to the success of the mission. Dr. Buckey's main accomplishments during the mission are listed.

  12. A decision model for planetary missions (United States)

    Hazelrigg, G. A., Jr.; Brigadier, W. L.


    Many techniques developed for the solution of problems in economics and operations research are directly applicable to problems involving engineering trade-offs. This paper investigates the use of utility theory for decision making in planetary exploration space missions. A decision model is derived that accounts for the objectives of the mission - science - the cost of flying the mission and the risk of mission failure. A simulation methodology for obtaining the probability distribution of science value and costs as a function spacecraft and mission design is presented and an example application of the decision methodology is given for various potential alternatives in a comet Encke mission.

  13. Limit of detection and threshold for positivity of the Centers for Disease Control and Prevention assay for factor VIII inhibitors. (United States)

    Miller, C H; Boylan, B; Shapiro, A D; Lentz, S R; Wicklund, B M


    Essentials Immunologic methods detect factor VIII (FVIII) antibodies in some inhibitor-negative specimens. Specimens were tested by modified Nijmegen-Bethesda assay (NBA) and fluorescence immunoassay. The NBA with preanalytical heat inactivation detects FVIII inhibitors down to 0.2 NBU. IgG 4 frequency validates the established threshold for positivity of ≥ 0.5 NBU for this NBA. Background The Bethesda assay for measurement of factor VIII inhibitors called for quantification of positive inhibitors by using dilutions producing 25-75% residual activity (RA), corresponding to 0.4-2.0 Bethesda units, with the use of 'more sensitive methods' for samples with RA closer to 100% being recommended. The Nijmegen modification (Nijmegen-Bethesda assay [NBA]) changed the reagents used but not these calculations. Some specimens negative by the NBA have been shown to have FVIII antibodies detectable with sensitive immunologic methods. Objective To examine the performance at very low inhibitor titers of the Centers for Disease Control and Prevention (CDC)-modified NBA (CDC-NBA), which includes preanalytic heat inactivation to liberate bound anti-FVIII antibodies. Methods Specimens with known inhibitors were tested with the CDC-NBA. IgG 4 anti-FVIII antibodies were measured by fluorescence immunoassay (FLI). Results Diluted inhibitors showed linearity below 0.4 Nijmegen-Bethesda units (NBU). With four statistical methods, the limit of detection of the CDC-NBA was determined to be 0.2 NBU. IgG 4 anti-FVIII antibodies, which correlate most strongly with functional inhibitors, were present at rates above the background rate of healthy controls in specimens with titers ≥ 0.2 NBU and showed an increase in frequency from 14.3% at 0.4 NBU to 67% at the established threshold for positivity of 0.5 NBU. Conclusions The CDC-NBA can detect inhibitors down to 0.2 NBU. The FLI, which is more sensitive, demonstrates anti-FVIII IgG 4 in some patients with negative (NBA, supporting the need for

  14. Factors Associated with the Time of Admission among Notified Dengue Fever Cases in Region VIII Philippines from 2008 to 2014.

    Directory of Open Access Journals (Sweden)

    Jason Echavez Abello


    Full Text Available In cases of Dengue fever, late hospital admission can lead to treatment delay and even death. In order to improve early disease notification and management, it is essential to investigate the factors affecting the time of admission of Dengue cases. This study determined the factors associated with the time of admission among notified Dengue cases. The study covered the period between 2008 and 2014 in Region VIII, Philippines. The factors assessed were age, sex, hospital sector, hospital level, disease severity based on the 1997 WHO Dengue classification, and period of admission (distinguishing between the 2010 Dengue epidemic and non-epidemic time. We analysed secondary data from the surveillance of notified Dengue cases. We calculated the association through chi-square test, ordinal logistic regression and linear regression at p value < 0.05. The study included 16,357 admitted Dengue cases. The reported cases included a majority of children (70.09%, mild cases of the disease (64.00%, patients from the public sector (69.82%, and non-tertiary hospitals (62.76%. Only 1.40% of cases had a laboratory confirmation. The epidemic period in 2010 comprised 48.68% of all the admitted cases during this period. Late admission was more likely among adults than children (p<0.05. The severe type of the disease was more likely to be admitted late than the mild type (p<0.05. Late admission was also more likely in public hospitals than in private hospitals (p<0.05; and within tertiary level hospitals than non-tertiary hospitals (p<0.05. Late admission was more likely during the non-epidemic period than the 2010 epidemic period (p<0.05. A case fatality rate of 1 or greater was significantly associated with children, severe diseases, tertiary hospitals and public hospitals when admitted late (p<0.05. Data suggests that early admission among child cases was common in Region VIII. This behavior is encouraging, and should be continued. However, further study is needed

  15. Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A. (United States)

    Nguyen, G N; George, L A; Siner, J I; Davidson, R J; Zander, C B; Zheng, X L; Arruda, V R; Camire, R M; Sabatino, D E


    Essentials Factor (F) VIII is an inefficiently expressed protein. Furin deletion FVIII variants were purified and characterized using in vitro and in vivo assays. These minimally modified novel FVIII variants have enhanced function. These variants provide a strategy for increasing FVIII expression in hemophilia A gene therapy. Background The major challenge for developing gene-based therapies for hemophilia A is that human factor VIII (hFVIII) has intrinsic properties that result in inefficient biosynthesis. During intracellular processing, hFVIII is predominantly cleaved at a paired basic amino acid cleaving enzyme (PACE) or furin cleavage site to yield a heterodimer that is the major form of secreted protein. Previous studies with B-domain-deleted (BDD) canine FVIII and hFVIII-R1645H, both differing from hFVIII by a single amino acid at this site, suggested that these proteins are secreted mainly in a single polypeptide chain (SC) form and exhibit enhanced function. Objective We hypothesized that deletion(s) of the furin site modulates FVIII biology and may enhance its function. Methods A series of recombinant hFVIII-furin deletion variants were introduced into hFVIII-BDD [Δ1645, 1645-46(Δ2), 1645-47(Δ3), 1645-48(Δ4), or Δ1648] and characterized. Results In vitro, recombinant purified Δ3 and Δ4 were primarily SC and, interestingly, had 2-fold higher procoagulant activity compared with FVIII-BDD. In vivo, the variants also have improved hemostatic function. After adeno-associated viral (AAV) vector delivery, the expression of these variants is 2-4-fold higher than hFVIII-BDD. Protein challenges of each variant in mice tolerant to hFVIII-BDD showed no anti-FVIII immune response. Conclusions These data suggest that the furin deletion hFVIII variants are superior to hFVIII-BDD without increased immunogenicity. In the setting of gene-based therapeutics, these novel variants provide a unique strategy to increase FVIII expression, thus lowering the vector dose, a

  16. ENDF/B-VIII.0: The 8th Major Release of the Nuclear Reaction Data Library with CIELO-project Cross Sections, New Standards and Thermal Scattering Data (United States)

    Brown, D. A.; Chadwick, M. B.; Capote, R.; Kahler, A. C.; Trkov, A.; Herman, M. W.; Sonzogni, A. A.; Danon, Y.; Carlson, A. D.; Dunn, M.; Smith, D. L.; Hale, G. M.; Arbanas, G.; Arcilla, R.; Bates, C. R.; Beck, B.; Becker, B.; Brown, F.; Casperson, R. J.; Conlin, J.; Cullen, D. E.; Descalle, M.-A.; Firestone, R.; Gaines, T.; Guber, K. H.; Hawari, A. I.; Holmes, J.; Johnson, T. D.; Kawano, T.; Kiedrowski, B. C.; Koning, A. J.; Kopecky, S.; Leal, L.; Lestone, J. P.; Lubitz, C.; Márquez Damián, J. I.; Mattoon, C. M.; McCutchan, E. A.; Mughabghab, S.; Navratil, P.; Neudecker, D.; Nobre, G. P. A.; Noguere, G.; Paris, M.; Pigni, M. T.; Plompen, A. J.; Pritychenko, B.; Pronyaev, V. G.; Roubtsov, D.; Rochman, D.; Romano, P.; Schillebeeckx, P.; Simakov, S.; Sin, M.; Sirakov, I.; Sleaford, B.; Sobes, V.; Soukhovitskii, E. S.; Stetcu, I.; Talou, P.; Thompson, I.; van der Marck, S.; Welser-Sherrill, L.; Wiarda, D.; White, M.; Wormald, J. L.; Wright, R. Q.; Zerkle, M.; Žerovnik, G.; Zhu, Y.


    We describe the new ENDF/B-VIII.0 evaluated nuclear reaction data library. ENDF/B-VIII.0 fully incorporates the new IAEA standards, includes improved thermal neutron scattering data and uses new evaluated data from the CIELO project for neutron reactions on 1H, 16O, 56Fe, 235U, 238U and 239Pu described in companion papers in the present issue of Nuclear Data Sheets. The evaluations benefit from recent experimental data obtained in the U.S. and Europe, and improvements in theory and simulation. Notable advances include updated evaluated data for light nuclei, structural materials, actinides, fission energy release, prompt fission neutron and γ-ray spectra, thermal neutron scattering data, and charged-particle reactions. Integral validation testing is shown for a wide range of criticality, reaction rate, and neutron transmission benchmarks. In general, integral validation performance of the library is improved relative to the previous ENDF/B-VII.1 library.

  17. ENDF/B-VIII.0: The 8 th Major Release of the Nuclear Reaction Data Library with CIELO-project Cross Sections, New Standards and Thermal Scattering Data

    Energy Technology Data Exchange (ETDEWEB)

    Brown, D. A.; Chadwick, M. B.; Capote, R.; Kahler, A. C.; Trkov, A.; Herman, M. W.; Sonzogni, A. A.; Danon, Y.; Carlson, A. D.; Dunn, M.; Smith, D. L.; Hale, G. M.; Arbanas, G.; Arcilla, R.; Bates, C. R.; Beck, B.; Becker, B.; Brown, F.; Casperson, R. J.; Conlin, J.; Cullen, D. E.; Descalle, M. -A.; Firestone, R.; Gaines, T.; Guber, K. H.; Hawari, A. I.; Holmes, J.; Johnson, T. D.; Kawano, T.; Kiedrowski, B. C.; Koning, A. J.; Kopecky, S.; Leal, L.; Lestone, J. P.; Lubitz, C.; Márquez Damián, J. I.; Mattoon, C. M.; McCutchan, E. A.; Mughabghab, S.; Navratil, P.; Neudecker, D.; Nobre, G. P. A.; Noguere, G.; Paris, M.; Pigni, M. T.; Plompen, A. J.; Pritychenko, B.; Pronyaev, V. G.; Roubtsov, D.; Rochman, D.; Romano, P.; Schillebeeckx, P.; Simakov, S.; Sin, M.; Sirakov, I.; Sleaford, B.; Sobes, V.; Soukhovitskii, E. S.; Stetcu, I.; Talou, P.; Thompson, I.; van der Marck, S.; Welser-Sherrill, L.; Wiarda, D.; White, M.; Wormald, J. L.; Wright, R. Q.; Zerkle, M.; Žerovnik, G.; Zhu, Y.


    We describe the new ENDF/B-VIII.0 evaluated nuclear reaction data library. ENDF/B-VIII.0 fully incorporates the new IAEA standards, includes improved thermal neutron scattering data and uses new evaluated data from the CIELO project for neutron reactions on 1H, 16O, 56Fe, 235U, 238U and 239Pu described in companion papers in the present issue of Nuclear Data Sheets. The evaluations benefit from recent experimental data obtained in the U.S. and Europe, and improvements in theory and simulation. Notable advances include updated evaluated data for light nuclei, structural materials, actinides, fission energy release, prompt fission neutron and γ-ray spectra, thermal neutron scattering data, and charged-particle reactions. Integral validation testing is shown for a wide range of criticality, reaction rate, and neutron transmission benchmarks. In general, integral validation performance of the library is improved relative to the previous ENDF/B-VII.1 library.

  18. Xenia Mission: Spacecraft Design Concept (United States)

    Hopkins, R. C.; Johnson, C. L.; Kouveliotou, C.; Jones, D.; Baysinger, M.; Bedsole, T.; Maples, C. C.; Benfield, P. J.; Turner, M.; Capizzo, P.; hide


    The proposed Xenia mission will, for the first time, chart the chemical and dynamical state of the majority of baryonic matter in the universe. using high-resolution spectroscopy, Xenia will collect essential information from major traces of the formation and evolution of structures from the early universe to the present time. The mission is based on innovative instrumental and observational approaches: observing with fast reaction gamma-ray bursts (GRBs) with a high spectral resolution. This enables the study of their (star-forming) environment from the dark to the local universe and the use of GRBs as backlight of large-scale cosmological structures, observing and surveying extended sources with high sensitivity using two wide field-of-view x-ray telescopes - one with a high angular resolution and the other with a high spectral resolution.

  19. The Van Allen Probes mission

    CERN Document Server

    Burch, James


    This collection of articles provides broad and detailed information about NASA’s Van Allen Probes (formerly known as the Radiation Belt Storm Probes) twin-spacecraft Earth-orbiting mission. The mission has the objective of achieving predictive understanding of the dynamic, intense, energetic, dangerous, and presently unpredictable belts of energetic particles that are magnetically trapped in Earth’s space environment above the atmosphere. It documents the science of the radiation belts and the societal benefits of achieving predictive understanding. Detailed information is provided about the Van Allen Probes mission design, the spacecraft, the science investigations, and the onboard instrumentation that must all work together to make unprecedented measurements within a most unforgiving environment, the core of Earth’s most intense radiation regions.
 This volume is aimed at graduate students and researchers active in space science, solar-terrestrial interactions and studies of the up...

  20. Gaia Space Mission and Quasars

    Energy Technology Data Exchange (ETDEWEB)

    Zwitter, Tomaž, E-mail: [Faculty of Mathematics and Physics, University of Ljubljana, Ljubljana (Slovenia)


    Quasars are often considered to be point-like objects. This is largely true and allows for an excellent alignment of the optical positional reference frame of the ongoing ESA mission Gaia with the International Celestial Reference Frame. But presence of optical jets in quasars can cause shifts of the optical photo-centers at levels detectable by Gaia. Similarly, motion of emitting blobs in the jet can be detected as proper motion shifts. Gaia's measurements of spectral energy distribution for around a million distant quasars is useful to determine their redshifts and to assess their variability on timescales from hours to years. Spatial resolution of Gaia allows to build a complete magnitude limited sample of strongly lensed quasars. The mission had its first public data release in September 2016 and is scheduled to have the next and much more comprehensive one in April 2018. Here we briefly review the capabilities and current results of the mission. Gaia's unique contributions to the studies of quasars are already being published, a highlight being a discovery of a number of quasars with optical jets.

  1. The SOLAR-C Mission (United States)

    Suematsu, Y.


    The Solar-C is a Japan-led international solar mission planned to be launched in mid2020. It is designed to investigate the magnetic activities of the Sun, focusing on the study in heating and dynamical phenomena of the chromosphere and corona, and also to develop an algorithm for predicting short and long term solar evolution. Since it has been revealed that the different parts of the magnetized solar atmosphere are essentially coupled, the SOLAR-C should tackle the spatial scales and temperature regimes that need to be observed in order to achieve a comprehensive physical understanding of this coupling. The science of Solar-C will greatly advance our understanding of the Sun, of basic physical processes operating throughout the universe. To dramatically improve the situation, SOLAR-C will carry three dedicated instruments; the Solar UV-Vis-IR Telescope (SUVIT), the EUV Spectroscopic Telescope (EUVST) and the High Resolution Coronal Imager (HCI), to jointly observe the entire visible solar atmosphere with essentially the same high spatial resolution (0.1-0.3 arcsec), performing high resolution spectroscopic measurements over all atmospheric regions and spectro-polarimetric measurements from the photosphere through the upper chromosphere. In addition, Solar-C will contribute to our understanding on the influence of the Sun-Earth environments with synergetic wide-field observations from ground-based and other space missions. Some leading science objectives and the mission concept, including designs of the three instruments aboard SOLAR-C will be presented.

  2. Hubungan Self-esteem dan Penggunaan Media Sosial Instagram dengan Perilaku Narsisme di Kalangan Siswa Kelas VIII Smpk Penabur Bintaro Jaya


    Wibowo, Yonatan; Silaen, Sondang Maria J


    Tujuan dari penelitian ini adalah untuk mengetahui ada tidaknya hubungan self-esteem dan penggunaanmedia sosial Instagram dengan perilaku narsisme di kalangan siswa kelas VIII SMPK Penabur Bintaro Jaya.Dalam penelitian ini terdapat tiga variabel, yaitu perilaku narsisme sebagai variabel terikat serta self-esteem danpenggunaan media sosial Instagram sebagai variabel bebas. Sampel dalam penelitian ini adalah siswa kelasdelapan tahun pelajaran 2016/2017. Teknik pengambilan sampel dalam penelitia...

  3. Influence of V/III growth flux ratio on trap states in m-plane GaN grown by ammonia-based molecular beam epitaxy

    International Nuclear Information System (INIS)

    Zhang, Z.; Arehart, A. R.; Hurni, C. A.; Speck, J. S.; Ringel, S. A.


    Deep level transient spectroscopy (DLTS) and deep level optical spectroscopy (DLOS) were utilized to investigate the behavior of deep states in m-plane, n-type GaN grown by ammonia-based molecular beam epitaxy (NH 3 -MBE) as a function of systematically varied V/III growth flux ratios. Levels were detected at E C - 0.14 eV, E C - 0.21 eV, E C - 0.26 eV, E C - 0.62 eV, E C - 0.67 eV, E C - 2.65 eV, and E C - 3.31 eV, with the concentrations of several traps exhibiting systematic dependencies on V/III ratio. The DLTS spectra are dominated by traps at E C - 0.14 eV and E C - 0.67 eV, whose concentrations decreased monotonically with increasing V/III ratio and decreasing oxygen impurity concentration, and by a trap at E C - 0.21 eV that revealed no dependence of its concentration on growth conditions, suggestive of different physical origins. Higher concentrations of deeper trap states detected by DLOS with activation energies of E C - 2.65 eV and E C - 3.31 eV in each sample did not display measureable sensitivity to the intentionally varied V/III ratio, necessitating further study on reducing these deep traps through growth optimization for maximizing material quality of NH 3 -MBE grown m-plane GaN.

  4. Anterior Inferior Cerebellar Arteries Juxtaposed with the Internal Acoustic Meatus and Their Relationship to the Cranial Nerve VII/VIII Complex. (United States)

    Alonso, Fernando; Kassem, Mohammad W; Iwanaga, Joe; Oskouian, Rod J; Loukas, Marios; Demerdash, Amin; Tubbs, R Shane


    Vascular loops in the cerebellopontine angle (CPA) and their relationship to cranial nerves have been used to explain neurological symptoms. The anterior inferior cerebellar artery (AICA) has variable branches producing vascular loops that can compress the facial cranial nerve (CN) VII and vestibulocochlear (CN VIII) nerves. AICA compression of the facial-vestibulocochlear nerve complex can lead to various clinical presentations, including hemifacial spasm (HFS), tinnitus, and hemiataxia. The formation of arterial loops inside or outside of the internal auditory meatus (IAM) can cause abutment or compression of CN VII and CN VIII. Twenty-five (50 sides) fresh adult cadavers underwent dissection of the cerebellopontine angle in the supine position. In regard to relationships between the AICA and the nerves of the facial/vestibulocochlear complex, 33 arteries (66%) traveled in a plane between the facial/nervus intermedius nerves and the cochlear and vestibular nerves. Five arteries (10%) traveled below the CN VII/VIII complex, six (12%) traveled posterior to the nerve complex, four (8%) formed a semi-circle around the upper half of the nerve complex, and two (4%) traveled between and partially separated the nervus intermedius and facial nerve proper. Our study found that the majority of AICA will travel in a plane between the facial/nervus intermedius nerves and the cochlear and vestibular nerves. Although the relationship between the AICA and porus acusticus and AICA and the nerves of the CN VII/VIII complex are variable, based on our findings, some themes exist. Surgeons should consider these with approaches to the cerebellopontine angle.


    Directory of Open Access Journals (Sweden)

    Diinul Qoyyimah


    Full Text Available Aktivitas siswa kelas VIII pada mata pelajaran ekonomi SMP Negeri 24 Semarang pada pokok bahasan pasar masih rendah sehingga berdampak pada hasil belajar siswa yang masih dibawah KKM. Salah satu penyebabnya karena guru masih menerapkan metode belajar yang sama dalam waktu yang lama sehingga mengakibatkan rendahnya perolehan hasil belajar. Melalui penerapan metode ceramah bervariasi dan resitasi diharapkan siswa dapat belajar dengan santai dan senang dalam mengikuti proses pembelajaran. Penelitian ini bertujuan untuk mengetahui penerapan metode resitasi, dapat meningkatkan aktivitas dan hasil belajar siswa. Metode penelitian menggunakan penelitian tindakan kelas. Prosedur penelitian dilakukan dimulai dengan perencanaan, pelaksanaan, observasi dan refleksi. Metode pengumpulan data dengan dokumentasi dan tes. Hasil penelitian menyatakan bahwa ada peningkatan aktivitas siswa dan hasil belajar siswa materi pasar pada kelas VIII SMP Negeri 24 Semarang tahun 2013/2014. The students’ activity in VIII class of economic subject in SMP Negeri 24 Semarang in the subject matter of market topic is still low so it has the impact on the students’ learning outcome which is still under KKM requirements. One of the causes is because the teachers are still apply the same learning method in a long time so it resulted in low learning outcomes acquisition.through the application of various conventional methods and recitation are expected that students can learn easily and pleasure in participating of learning process. This study aims to determine the application of recitation method which can improve the activity and students’ learning outcomes. The research method using classroom action research. The research procedure begins with planning, implementation, observation and reflection. Methods of data collection carried out by documentation and test. The result of research states that there is an increasing activity and students’ learning outcomes in the

  6. Multi-Mission SDR, Phase II (United States)

    National Aeronautics and Space Administration — Wireless transceivers used for NASA space missions have traditionally been highly custom and mission specific. Programs such as the GRC Space Transceiver Radio...

  7. UAV Mission Planning: From Robust to Agile

    NARCIS (Netherlands)

    Evers, L.; Barros, A.I.; Monsuur, H.; Wagelmans, A.


    Unmanned Aerial Vehicles (UAVs) are important assets for information gathering in Intelligence Surveillance and Reconnaissance (ISR) missions. Depending on the uncertainty in the planning parameters, the complexity of the mission and its constraints and requirements, different planning methods might

  8. New Global Missions for Strategic Command

    National Research Council Canada - National Science Library

    Graham, David


    .... The focus of this White Paper is on the external decisions that will be needed to provide the Command with a clear mission, and the authority, resources and organizational support necessary to perform the mission...

  9. IceBridge Mission Flight Reports (United States)

    National Aeronautics and Space Administration — The IceBridge Mission Flight Reports data set contains flight reports from NASA Operation IceBridge Greenland, Arctic, Antarctic, and Alaska missions. Flight reports...

  10. Mercury Lander Mission Concept Study Summary (United States)

    Eng, D. A.


    Provides a summary of the Mercury Lander Mission Concept Study performed as part of the last Planetary Decadal Survey. The presentation will focus on engineering trades and the challenges of developing a Mercury lander mission.


    Directory of Open Access Journals (Sweden)

    Ricci Gemarni Tatalia, M.Pd


    Full Text Available This study was generated from the problem of students’ ability in writing news texts ini class VIII, SMPN 1 Panti. Some of the problem were (1 lack of the students’ response towards news writing teaching and learning process, (2 lack of teacher’s creativity in designing interesting news sriting learning model, (3 no appropriate creative techniques applied by the teacher which could train the students to develop their skill in writing news texts and (4 lack of the students’ motivation in participating in teaching and learning process because of their lack of understanding in the elements of news. Thus, this study was aimed at escribing the effect of the students’ ability ini writing news texts in class VIII SMP N 1 Panti. This was a quantitative research with factorial 2x2 experimental design. The population was the students in class VIII SMPN 1 Panti. Sampling technique was done by using random sampling and the data was collected through test. The result of the study revealed that cooperative learning model with STAD mind mapping type affected the students’ ability in writing news texts

  12. Design local exhaust ventilation on sieve machine at PT.Perkebunan Nusantara VIII Ciater using design for assembly (DFA) approach with Boothroyd and Dewhurst method (United States)

    Khalqihi, K. I.; Rahayu, M.; Rendra, M.


    PT Perkebunan Nusantara VIII Ciater is a company produced black tea orthodox more or less 4 tons every day. At the production section, PT Perkebunan Nusantara VIII will use local exhaust ventilation specially at sortation area on sieve machine. To maintain the quality of the black tea orthodox, all machine must be scheduled for maintenance every once a month and takes time 2 hours in workhours, with additional local exhaust ventilation, it will increase time for maintenance process, if maintenance takes time more than 2 hours it will caused production process delayed. To support maintenance process in PT Perkebunan Nusantara VIII Ciater, designing local exhaust ventilation using design for assembly approach with Boothroyd and Dewhurst method, design for assembly approach is choosen to simplify maintenance process which required assembly process. There are 2 LEV designs for this research. Design 1 with 94 components, assembly time 647.88 seconds and assembly efficiency level 23.62%. Design 2 with 82 components, assembly time 567.84 seconds and assembly efficiency level 24.83%. Design 2 is choosen for this research based on DFA goals, minimum total part that use, optimization assembly time, and assembly efficiency level.

  13. The influence of growth temperature and input V/III ratio on the initial nucleation and material properties of InN on GaN by MOCVD

    International Nuclear Information System (INIS)

    Wang, H; Jiang, D S; Zhu, J J; Zhao, D G; Liu, Z S; Wang, Y T; Zhang, S M; Yang, H


    The effects of growth temperature and V/III ratio on the InN initial nucleation of islands on the GaN (0 0 0 1) surface were investigated. It is found that InN nuclei density increases with decreasing growth temperature between 375 and 525 °C. At lower growth temperatures, InN thin films take the form of small and closely packed islands with diameters of less than 100 nm, whereas at elevated temperatures the InN islands can grow larger and well separated, approaching an equilibrium hexagonal shape due to enhanced surface diffusion of adatoms. At a given growth temperature of 500 °C, a controllable density and size of separated InN islands can be achieved by adjusting the V/III ratio. The larger islands lead to fewer defects when they are coalesced. Comparatively, the electrical properties of the films grown under higher V/III ratio are improved

  14. Science Mission Definition Studies for TROPIX (United States)

    Fennell, J. F.


    This document summarizes the results of mission definition studies for solar electric propulsion missions that have been carried out over the last approximately three years. The major output from the studies has been two proposals which were submitted to NASA in response to Announcements of Opportunity for missions and an ongoing Global Magnetospheric Dynamics mission study. The bulk of this report consists of copies of the proposals and preliminary materials from the GMD study that will be completed in the coming months.

  15. CHEOPS: A transit photometry mission for ESA's small mission programme

    Directory of Open Access Journals (Sweden)

    Queloz D.


    Full Text Available Ground based radial velocity (RV searches continue to discover exoplanets below Neptune mass down to Earth mass. Furthermore, ground based transit searches now reach milli-mag photometric precision and can discover Neptune size planets around bright stars. These searches will find exoplanets around bright stars anywhere on the sky, their discoveries representing prime science targets for further study due to the proximity and brightness of their host stars. A mission for transit follow-up measurements of these prime targets is currently lacking. The first ESA S-class mission CHEOPS (CHaracterizing ExoPlanet Satellite will fill this gap. It will perform ultra-high precision photometric monitoring of selected bright target stars almost anywhere on the sky with sufficient precision to detect Earth sized transits. It will be able to detect transits of RV-planets by photometric monitoring if the geometric configuration results in a transit. For Hot Neptunes discovered from the ground, CHEOPS will be able to improve the transit light curve so that the radius can be determined precisely. Because of the host stars' brightness, high precision RV measurements will be possible for all targets. All planets observed in transit by CHEOPS will be validated and their masses will be known. This will provide valuable data for constraining the mass-radius relation of exoplanets, especially in the Neptune-mass regime. During the planned 3.5 year mission, about 500 targets will be observed. There will be 20% of open time available for the community to develop new science programmes.

  16. A post-marketing safety and efficacy assessment of a monoclonal antibody purified high-purity factor VIII concentrate. (United States)

    Hay, C R; Lee, C A; Savidge, G


    The identification of infrequent side-effects of clotting factor concentrates, undetected by clinical trials, is facilitated by post-marketing surveillance. We present a post-marketing surveillance study in which 97 patients with haemophilia A, attending three haemophilia centres, were treated over a median follow-up period of 284 days (range 1-1074), and a total follow-up period of 30,080 days, with a pasteurized immunoaffinity purified factor VIII concentrate (Monoclate-P, Armour, Collegeville, USA). 5216 infusions, using 10,527,000 units of Monoclate-P, were carried out, mostly for routine haemarthroses or prophylaxis. No new inhibitors were observed during the study. At the start of the study 60/97 were HIV seropositive, 67/97 HBs antibody positive, 12 HbsAb negative and the remainder HBsAb positive before the study period. 13/14 tested were HAV seropositive at the beginning of the study. One patient became HAV seropositive during the study period, an infection thought to be community acquired. No other seroconversions were observed. Only one mild transfusion reaction was observed. This study confirms the safety and efficacy of Monoclate-P. Post-marketing surveillance or nationally organized pharmaco-vigilance should be practiced more widely to enable identification of low-frequency side-effects of treatment.

  17. Direct Observation of the M1 Transition between the Ground Term Fine Structure Levels of W VIII

    Directory of Open Access Journals (Sweden)

    Momoe Mita


    Full Text Available We present a direct observation of the M1 transition between the fine structure splitting in the 4 f 13 5 s 2 5 p 6 2 F ground term of W VIII. The spectroscopic data of few-times ionized tungsten ions are important for the future ITER diagnostics, but there is a serious lack of data. The present study is part of an ongoing effort to solve this problem. Emission from the tungsten ions produced and trapped in a compact electron beam ion trap is observed with a Czerny–Turner visible spectrometer. Spectra in the EUV range are also observed at the same time to help identify the previously-unreported visible lines. The observed wavelength 574.47 ± 0.03 nm (air, which corresponds to the fine structure splitting of 17,402.5 ± 0.9 cm − 1 , shows reasonable agreement with the previously reported value 17,410 ± 5 cm − 1 obtained indirectly through the analysis of EUV spectra [Ryabtsev et al., Atoms 3 (2015 273].

  18. Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A. (United States)

    Collins, P W; Blanchette, V S; Fischer, K; Björkman, S; Oh, M; Fritsch, S; Schroth, P; Spotts, G; Astermark, J; Ewenstein, B


    The role of prophylactic factor VIII (FVIII) to decrease hemophilic bleeding and arthropathy is well established. The rationale for this strategy is to convert patients with severe hemophilia A to a moderate clinical phenotype by reducing time spent with a FVIII level break-through bleeding in patients with severe hemophilia A on prophylaxis. This study analysed data from 44 patients aged 1-6 and 99 patients aged 10-65 years with severe hemophilia A (FVIII safety and efficacy of a recombinant FVIII (Advate). Each patient had pharmacokinetic measurements and FVIII infusions recorded, and these were used to calculate time spent with a FVIII below 1, 2 and 5 IU dL(-1). The data demonstrate that increasing time with a FVIII below 1 IU dL(-1) is associated with increased total bleeds and hemarthroses. Lack of adherence to the intended frequency of FVIII infusion was the most important determinant of low FVIII and increased bleeding. In children aged 1-6 years, the rate of bleeding was also influenced by FVIII half-life and clearance. These data have important implications for the management of patients with severe hemophilia.

  19. Factors Associated with the Time of Admission among Notified Dengue Fever Cases in Region VIII Philippines from 2008 to 2014. (United States)

    Abello, Jason Echavez; Gil Cuesta, Julita; Cerro, Boyd Roderick; Guha-Sapir, Debarati


    In cases of Dengue fever, late hospital admission can lead to treatment delay and even death. In order to improve early disease notification and management, it is essential to investigate the factors affecting the time of admission of Dengue cases. This study determined the factors associated with the time of admission among notified Dengue cases. The study covered the period between 2008 and 2014 in Region VIII, Philippines. The factors assessed were age, sex, hospital sector, hospital level, disease severity based on the 1997 WHO Dengue classification, and period of admission (distinguishing between the 2010 Dengue epidemic and non-epidemic time). We analysed secondary data from the surveillance of notified Dengue cases. We calculated the association through chi-square test, ordinal logistic regression and linear regression at p value Dengue cases. The reported cases included a majority of children (70.09%), mild cases of the disease (64.00%), patients from the public sector (69.82%), and non-tertiary hospitals (62.76%). Only 1.40% of cases had a laboratory confirmation. The epidemic period in 2010 comprised 48.68% of all the admitted cases during this period. Late admission was more likely among adults than children (pDengue guidelines in order to standardize the admission criteria and time across hospitals.

  20. Elevated plasma factor VIII enhances venous thrombus formation in rabbits: contribution of factor XI, von Willebrand factor and tissue factor. (United States)

    Sugita, Chihiro; Yamashita, Atsushi; Matsuura, Yunosuke; Iwakiri, Takashi; Okuyama, Nozomi; Matsuda, Shuntaro; Matsumoto, Tomoko; Inoue, Osamu; Harada, Aya; Kitazawa, Takehisa; Hattori, Kunihiro; Shima, Midori; Asada, Yujiro


    Elevated plasma levels of factor VIII (FVIII) are associated with increased risk of deep venous thrombosis. The aim of this study is to elucidate how elevated FVIII levels affect venous thrombus formation and propagation in vivo. We examined rabbit plasma FVIII activity, plasma thrombin generation, whole blood coagulation, platelet aggregation and venous wall thrombogenicity before and one hour after an intravenous infusion of recombinant human FVIII (rFVIII). Venous thrombus induced by the endothelial denudation of rabbit jugular veins was histologically assessed. Thrombus propagation was evaluated as indocyanine green fluorescence intensity. Argatroban, a thrombin inhibitor, and neutralised antibodies for tissue factor (TF), factor XI (FXI), and von Willebrand factor (VWF) were infused before or after thrombus induction to investigate their effects on venous thrombus formation or propagation. Recombinant FVIII (100 IU/kg) increased rabbit plasma FVIII activity two-fold and significantly enhanced whole blood coagulation and total plasma thrombin generation, but did not affect initial thrombin generation time, platelet aggregation and venous wall thrombogenicity. The rFVIII infusion also increased the size of venous thrombus 1 hour after thrombus induction. Argatroban and the antibodies for TF, FXI or VWF inhibited such enhanced thrombus formation and all except TF suppressed thrombus propagation. In conclusion, elevated plasma FVIII levels enhance venous thrombus formation and propagation. Excess thrombin generation by FXI and VWF-mediated FVIII recruitment appear to contribute to the growth of FVIII-driven venous thrombus.

  1. An Acquired Factor VIII Inhibitor in a Patient with HIV and HCV: A Case Presentation and Literature Review

    Directory of Open Access Journals (Sweden)

    S. B. Zeichner


    Full Text Available Introduction. Despite its low incidence, acquired factor VIII inhibitor is the most common autoantibody affecting the clotting cascade. The exact mechanism of acquisition remains unclear, but postpartum patients, those with autoimmune conditions or malignancies, and those with exposure to particular drugs appear most susceptible. There have been several case reports describing acquired FVIII inhibitors in patients receiving interferon alpha for HCV treatment and in patients being treated for HIV. To our knowledge, this is the first case of a patient with HCV and HIV who was not actively receiving treatment for either condition. Case Presentation. A 57-year-old Caucasian male with a history of HIV and HCV was admitted to our hospital for a several day history of progressively worsening right thigh bruising and generalized weakness. CTA of the abdominal arteries revealed large bilateral retroperitoneal hematomas. Laboratory studies revealed the presence of a high titer FVIII inhibitor. Conclusion. Our case of a very rare condition highlights the importance of recognizing and understanding the diagnosis of acquired FVIII inhibitor. Laboratory research and clinical data on the role of newer agents are needed in order to better characterize disease pathogenesis, disease associations, genetic markers, and optimal disease management.

  2. Potency determination of factor VIII and factor IX for new product labelling and postinfusion testing: challenges for caregivers and regulators. (United States)

    Dodt, J; Hubbard, A R; Wicks, S J; Gray, E; Neugebauer, B; Charton, E; Silvester, G


    A workshop organized by the European Medicines Agency and the European Directorate for the Quality of Medicines and HealthCare was held in London, UK on November 28-29, 2013, to provide an overview of the current knowledge of the characterization of new factor VIII (FVIII) and factor IX (FIX) concentrates with respect to potency assays and testing of postinfusion material. The objective was to set the basis for regulatory authorities' discussion on the most appropriate potency assay for the individual products, and European Pharmacopoeia (Ph. Eur.) discussion on whether to propose revision of the Ph. Eur. monographs with respect to potency assays in the light of information on new FVIII and FIX concentrates. The workshop showed that for all products valid assays vs. the international concentrate standards were obtained and potency could be expressed in International Units. The Ph. Eur. chromogenic potency assay gave valid assay results which correlate with in vivo functionality of rFVIII products. For some modified rFVIII products and all modified rFIX products, one-stage clotting assay methods result in different potencies depending on the activated partial thromboplastin time reagent. As a consequence, monitoring of patients' postinfusion levels is challenging but it was pointed out that manufacturers are responsible for providing the users with appropriate information for use and laboratory testing of their product. Strategies to avoid misleading determination of patents' plasma levels, e.g. information on suitable assays, laboratory standards or correction factors were discussed. © 2015 John Wiley & Sons Ltd.

  3. Genotype and phenotype report on patients with combined deficiency of factor V and factor VIII in Iran. (United States)

    Karimi, Mehran; Cairo, Andrea; Safarpour, Mohammad M; Haghpanah, Sezaneh; Ekramzadeh, Maryam; Afrasiabi, Abdolreza; Shahriari, Mahdi; Menegatti, Marzia


    Combined factor V (FV) and factor VIII (FVIII) deficiency is a rare autosomal recessive bleeding disorder characterized by mild-to-moderate bleeding. Epistaxis, postsurgical bleeding and menorrhagia are the most common symptoms. The aim of this study is to report the phenotype-genotype characterization carried out in patients affected with combined FV and FVIII deficiency from Iran. A cross-sectional study was conducted in Shiraz Hemophilia Center, southern Iran. Twelve cases, seven men and five women coming from eight families were included in our study after taking consent form. Coagulation activity for all patients was measured. All exons and intron-exon junctions of lectin mannose binding protein 1 (LMAN1) gene and multiple coagulation factor deficiency 2 genes were amplified by PCR, and subsequently sequenced by the Sanger method. Patients[Combining Acute Accent] age ranged from 6 to 59 years mean ± SD: 23.8 ± 15.4 years and median: 22 years. No patient presented with severe bleeding symptom. Only one patient had severe FV and FVIII deficiency (both factor levels stop codon. Larger studies are needed to calculate the correlation between factor levels, genetic and bleeding symptoms.

  4. Mechanical design of the Mars Pathfinder mission (United States)

    Eisen, Howard Jay; Buck, Carl W.; Gillis-Smith, Greg R.; Umland, Jeffrey W.


    The Mars Pathfinder mission and the Sojourner rover is reported on, with emphasis on the various mission steps and the performance of the technologies involved. The mechanical design of mission hardware was critical to the success of the entry sequence and the landing operations. The various mechanisms employed are considered.

  5. Telecentre Network Startup : Bangladesh - Mission 2011 | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The second generation of telecentres has seen the emergence of national-level networks in various parts of the word including the Ugandan Telecentre Network, Mission 2007 in India and Mission Swaabhimaan in Nepal. Telecentre stakeholders in Bangladesh would like to replicate the methodology used in Mission 2007, ...

  6. The Ionospheric Connection Explorer Mission: Mission Goals and Design (United States)

    Immel, T. J.; England, S. L.; Mende, S. B.; Heelis, R. A.; Englert, C. R.; Edelstein, J.; Frey, H. U.; Korpela, E. J.; Taylor, E. R.; Craig, W. W.; Harris, S. E.; Bester, M.; Bust, G. S.; Crowley, G.; Forbes, J. M.; Gérard, J.-C.; Harlander, J. M.; Huba, J. D.; Hubert, B.; Kamalabadi, F.; Makela, J. J.; Maute, A. I.; Meier, R. R.; Raftery, C.; Rochus, P.; Siegmund, O. H. W.; Stephan, A. W.; Swenson, G. R.; Frey, S.; Hysell, D. L.; Saito, A.; Rider, K. A.; Sirk, M. M.


    The Ionospheric Connection Explorer, or ICON, is a new NASA Explorer mission that will explore the boundary between Earth and space to understand the physical connection between our world and our space environment. This connection is made in the ionosphere, which has long been known to exhibit variability associated with the sun and solar wind. However, it has been recognized in the 21st century that equally significant changes in ionospheric conditions are apparently associated with energy and momentum propagating upward from our own atmosphere. ICON's goal is to weigh the competing impacts of these two drivers as they influence our space environment. Here we describe the specific science objectives that address this goal, as well as the means by which they will be achieved. The instruments selected, the overall performance requirements of the science payload and the operational requirements are also described. ICON's development began in 2013 and the mission is on track for launch in 2018. ICON is developed and managed by the Space Sciences Laboratory at the University of California, Berkeley, with key contributions from several partner institutions.

  7. Retrieving Baseflow from SWOT Mission (United States)

    Baratelli, F.; Flipo, N.; Biancamaria, S.; Rivière, A.


    The quantification of aquifer contribution to river discharge is of primary importance to evaluate the impact of climatic and anthropogenic stresses on the availability of water resources. Several baseflow estimation methods require river discharge measurements, which can be difficult to obtain at high spatio-temporal resolution for large scale basins. The SWOT satellite mission will provide discharge estimations for large rivers (50 - 100 m wide) even in remote basins. The frequency of these estimations depends on the position and ranges from zero to four values in the 21-days satellite cycle. This work aims at answering the following question: can baseflow be estimated from SWOT observations during the mission lifetime? An algorithm based on hydrograph separation by Chapman's filter was developed to automatically estimate the baseflow in a river network at regional or larger scale (> 10000 km2). The algorithm was first applied using the discharge time series simulated at daily time step by a coupled hydrological-hydrogeological model to obtain the reference baseflow estimations. The same algorithm is then forced with discharge time series sampled at SWOT observation frequency. The methodology was applied to the Seine River basin (65000 km2, France). The results show that the average baseflow is estimated with good accuracy for all the reaches which are observed at least once per cycle (relative bias less than 4%). The time evolution of baseflow is also rather well retrieved, with a Nash coefficient which is more than 0.7 for 94% of the network length. This work provides new potential for the SWOT mission in terms of global hydrological analysis.

  8. The 1.7 Å X-ray crystal structure of the porcine factor VIII C2 domain and binding analysis to anti-human C2 domain antibodies and phospholipid surfaces.

    Directory of Open Access Journals (Sweden)

    Caileen M Brison

    Full Text Available The factor VIII C2 domain is essential for binding to activated platelet surfaces as well as the cofactor activity of factor VIII in blood coagulation. Inhibitory antibodies against the C2 domain commonly develop following factor VIII replacement therapy for hemophilia A patients, or they may spontaneously arise in cases of acquired hemophilia. Porcine factor VIII is an effective therapeutic for hemophilia patients with inhibitor due to its low cross-reactivity; however, the molecular basis for this behavior is poorly understood. In this study, the X-ray crystal structure of the porcine factor VIII C2 domain was determined, and superposition of the human and porcine C2 domains demonstrates that most surface-exposed differences cluster on the face harboring the "non-classical" antibody epitopes. Furthermore, antibody-binding results illustrate that the "classical" 3E6 antibody can bind both the human and porcine C2 domains, although the inhibitory titer to human factor VIII is 41 Bethesda Units (BU/mg IgG versus 0.8 BU/mg IgG to porcine factor VIII, while the non-classical G99 antibody does not bind to the porcine C2 domain nor inhibit porcine factor VIII activity. Further structural analysis of differences between the electrostatic surface potentials suggest that the C2 domain binds to the negatively charged phospholipid surfaces of activated platelets primarily through the 3E6 epitope region. In contrast, the G99 face, which contains residue 2227, should be distal to the membrane surface. Phospholipid binding assays indicate that both porcine and human factor VIII C2 domains bind with comparable affinities, and the human K2227A and K2227E mutants bind to phospholipid surfaces with similar affinities as well. Lastly, the G99 IgG bound to PS-immobilized factor VIII C2 domain with an apparent dissociation constant of 15.5 nM, whereas 3E6 antibody binding to PS-bound C2 domain was not observed.

  9. GPS test range mission planning (United States)

    Roberts, Iris P.; Hancock, Thomas P.

    The principal features of the Test Range User Mission Planner (TRUMP), a PC-resident tool designed to aid in deploying and utilizing GPS-based test range assets, are reviewed. TRUMP features time history plots of time-space-position information (TSPI); performance based on a dynamic GPS/inertial system simulation; time history plots of TSPI data link connectivity; digital terrain elevation data maps with user-defined cultural features; and two-dimensional coverage plots of ground-based test range assets. Some functions to be added during the next development phase are discussed.

  10. Draft 1988 mission plan amendment

    International Nuclear Information System (INIS)


    This draft 1988 amendment to the Mission Plan for the Civilian Radioactive Waste Management Program has been prepared by the US Department of Energy (DOE). The purpose is to inform the Congress of the DOE's plans for implementing the provisions of the Nuclear Waste Policy Amendments Act of 1987 (P.L. 100-203) for the Civilian Radioactive Waste Management Program. This document is being submitted in draft form to Federal agencies, states, previously affected Indian Tribes, affected units of local government, and the public. After the consideration of comments, this amendment will be revised as appropriate and submitted to the Congress. 39 refs., 7 figs., 4 tabs

  11. Kepler planet-detection mission

    DEFF Research Database (Denmark)

    Borucki...[], William J.; Koch, David; Buchhave, Lars C. Astrup


    The Kepler mission was designed to determine the frequency of Earth-sized planets in and near the habitable zone of Sun-like stars. The habitable zone is the region where planetary temperatures are suitable for water to exist on a planet’s surface. During the first 6 weeks of observations, Kepler...... is one of the lowest-density planets (~0.17 gram per cubic centimeter) yet detected. Kepler-5b, -6b, and -8b confirm the existence of planets with densities lower than those predicted for gas giant planets....

  12. NASA CYGNSS Tropical Cyclone Mission (United States)

    Ruf, Chris; Atlas, Robert; Majumdar, Sharan; Ettammal, Suhas; Waliser, Duane


    The NASA Cyclone Global Navigation Satellite System (CYGNSS) mission consists of a constellation of eight microsatellites that were launched into low-Earth orbit on 15 December 2016. Each observatory carries a four-channel bistatic scatterometer receiver to measure near surface wind speed over the ocean. The transmitter half of the scatterometer is the constellation of GPS satellites. CYGNSS is designed to address the inadequacy in observations of the inner core of tropical cyclones (TCs) that result from two causes: 1) much of the TC inner core is obscured from conventional remote sensing instruments by intense precipitation in the eye wall and inner rain bands; and 2) the rapidly evolving (genesis and intensification) stages of the TC life cycle are poorly sampled in time by conventional polar-orbiting, wide-swath surface wind imagers. The retrieval of wind speed by CYGNSS in the presence of heavy precipitation is possible due to the long operating wavelength used by GPS (19 cm), at which scattering and attenuation by rain are negligible. Improved temporal sampling by CYGNSS is possible due to the use of eight spacecraft with 4 scatterometer channels on each one. Median and mean revisit times everywhere in the tropics are 3 and 7 hours, respectively. Wind speed referenced to 10m height above the ocean surface is retrieved from CYGNSS measurements of bistatic radar cross section in a manner roughly analogous to that of conventional ocean wind scatterometers. The technique has been demonstrated previously from space by the UK-DMC and UK-TDS missions. Wind speed is retrieved with 25 km spatial resolution and an uncertainty of 2 m/s at low wind speeds and 10% at wind speeds above 20 m/s. Extensive simulation studies conducted prior to launch indicate that there will be a significant positive impact on TC forecast skill for both track and intensity with CYGNSS measurements assimilated into HWRF numerical forecasts. Simulations of CYGNSS spatial and temporal sampling

  13. Magnetic Satellite Missions and Data

    DEFF Research Database (Denmark)

    Olsen, Nils; Kotsiaros, Stavros


    Although the first satellite observations of the Earth’s magnetic field were already taken more than 50 years ago, continuous geomagnetic measurements from space are only available since 1999. The unprecedented time-space coverage of this recent data set opened revolutionary new possibilities...... for exploring the Earth’s magnetic field from space. In this chapter we discuss characteristics of satellites measuring the geomagnetic field and report on past, present and upcoming magnetic satellite missions. We conclude with some basics about space magnetic gradiometry as a possible path for future...... exploration of Earth’s magnetic field with satellites....

  14. Paleolimnological studies of Laguna Chica of San Pedro (VIII Region: Diatoms, hydrocarbons and fatty acid records Estudio Paleolimnológico de Laguna Chica de San Pedro (VIII Región: Diatomeas, hidrocarburos y ácidos grasos

    Directory of Open Access Journals (Sweden)



    Full Text Available Diatom, hydrocarbons and fatty acid sedimentary records were used for reconstructing the recent (last 150 years palaeolimnological history of Laguna Chica of San Pedro (Concepción, VIII Región, Chile. Cluster analyses (Constrained Incremental Sum of Squares on the diatom data revealed three distinct periods. The first period (1883-1940's showed a pronounced increase in sedimentation rate and a slight increase in organic matter accumulation. In this period, eutrophic species (Aulacoseira granulata and Staurosira construens became increasingly dominant. From the 1940s until the 1970s the diatom signal is more equivocal: after the initial decrease in the relative abundance of A. granulata and S. construens their numbers fluctuate without a clear pattern. Sedimentation rates strongly fluctuate in this period. From 1978 onwards eutrophic species are in decline while indicators of oligotrophic conditions, such as Cyclotella stelligera and Aulacoseira distans, become more abundant. This shift in the lake trophic status could not be attributed to a reduction in the nutrient load from the catchment and we hypothesize that the invasion of the lake by the submersed macrophyte Egeria densa has altered nutrient availability to the plankton communities. This is in agreement with the hydrocarbons and fatty acid analyses which demonstrate a shift in carbon number distributions from short chain alkanes and alkanoic acids (typical for microalgae to long chain molecules (characteristic for higher plants in the upper layers of the lake sedimentSe realizó la reconstrucción histórica de los últimos 150 años de Laguna Chica de San Pedro (Concepción, VIII Región, Chile, a través de la utilización de los restos de diatomeas, hidrocarburos y ácidos grasos contenidos en la columna de sedimento. El análisis estratigráfico de las diatomeas reveló la presencia de tres períodos diferentes. El primer período (1883-1940's, mostró un marcado aumento de las

  15. Crew Transportation System Design Reference Missions (United States)

    Mango, Edward J.


    Contains summaries of potential design reference mission goals for systems to transport humans to andfrom low Earth orbit (LEO) for the Commercial Crew Program. The purpose of this document is to describe Design Reference Missions (DRMs) representative of the end-to-end Crew Transportation System (CTS) framework envisioned to successfully execute commercial crew transportation to orbital destinations. The initial CTS architecture will likely be optimized to support NASA crew and NASA-sponsored crew rotation missions to the ISS, but consideration may be given in this design phase to allow for modifications in order to accomplish other commercial missions in the future. With the exception of NASA’s mission to the ISS, the remaining commercial DRMs are notional. Any decision to design or scar the CTS for these additional non-NASA missions is completely up to the Commercial Provider. As NASA’s mission needs evolve over time, this document will be periodically updated to reflect those needs.

  16. Life support approaches for Mars missions (United States)

    Drysdale, A. E.; Ewert, M. K.; Hanford, A. J.

    Life support approaches for Mars missions are evaluated using an equivalent system mass (ESM) approach, in which all significant costs are converted into mass units. The best approach, as defined by the lowest mission ESM, depends on several mission parameters, notably duration, environment and consequent infrastructure costs, and crew size, as well as the characteristics of the technologies which are available. Generally, for the missions under consideration, physicochemical regeneration is most cost effective. However, bioregeneration is likely to be of use for producing salad crops for any mission, for producing staple crops for medium duration missions, and for most food, air and water regeneration for long missions (durations of a decade). Potential applications of in situ resource utilization need to be considered further.

  17. Flight mission control for multiple spacecraft (United States)

    Ryan, Robert E.


    A plan developed by the Jet Propulsion Laboratory for mission control of unmanned spacecraft is outlined. A technical matrix organization from which, in the past, project teams were formed to uniquely support a mission is replaced in this new plan. A cost effective approach was needed to make best use of limited resources. Mission control is a focal point operations and a good place to start a multimission concept. Co-location and sharing common functions are the keys to obtaining efficiencies at minimum additional risk. For the projects, the major changes are sharing a common operations area and having indirect control of personnel. The plan identifies the still direct link for the mission control functions. Training is a major element in this plan. Personnel are qualified for a position and certified for a mission. This concept is more easily accepted by new missions than the ongoing missions.

  18. Mission requirements for a manned earth observatory. Task 2: Reference mission definition and analyiss, volume 2 (United States)


    The mission requirements and conceptual design of manned earth observatory payloads for the 1980 time period are discussed. Projections of 1980 sensor technology and user data requirements were used to formulate typical basic criteria pertaining to experiments, sensor complements, and reference missions. The subjects discussed are: (1) mission selection and prioritization, (2) baseline mission analysis, (3) earth observation data handling and contingency plans, and (4) analysis of low cost mission definition and rationale.

  19. The Cassini-Huygens mission

    CERN Document Server

    The joint NASA-ESA Cassini-Huygens mission promises to return four (and possibly more) years of unparalleled scientific data from the solar system’s most exotic planet, the ringed, gas giant, Saturn. Larger than Galileo with a much greater communication bandwidth, Cassini can accomplish in a single flyby what Galileo returned in a series of passes. Cassini explores the Saturn environment in three dimensions, using gravity assists to climb out of the equatorial plane to look down on the rings from above, to image the aurora and to study polar magnetospheric processes such as field-aligned currents. Since the radiation belt particle fluxes are much more benign than those at Jupiter, Cassini can more safely explore the inner regions of the magnetosphere. The spacecraft approaches the planet closer than Galileo could, and explores the inner moons and the rings much more thoroughly than was possible at Jupiter. This book is the second volume, in a three volume set, that describes the Cassini/Huygens mission. Thi...


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    F. Gandor


    Full Text Available This paper presents a development of an open-source flight planning tool for Remotely Piloted Aircraft Systems (RPAS that is dedicated to high-precision photogrammetric mapping. This tool contains planning functions that are usually available in professional mapping systems for manned aircrafts as well as new features related to GPS signal masking in complex (e.g. mountainous terrain. The application is based on the open-source Java SDK (Software Development Kit World Wind from NASA that contains the main geospatial components facilitating the development itself. Besides standard planning functions known from other mission planners, we mainly focus on additional features dealing with safety and accuracy, such as GPS quality assessment. The need for the development came as a response for unifying mission planning across different platforms (e.g. rotary or fixed wing operating over terrain of different complexity. A special attention is given to the user interface, that is intuitive to use and cost-effective with respect to computer resources.

  1. The Simbol-X Mission

    International Nuclear Information System (INIS)

    Ferrando, P.; Goldwurm, A.; Laurent, P.; Lebrun, F.; Arnaud, M.; Briel, U.; Cavazzuti, E.; Giommi, P.; Piermaria, M.; Cledassou, R.; Counil, J. L.; Lamarle, O.; Fiore, F.; Malaguti, G.; Mereghetti, S.; Micela, G.; Pareschi, G.; Tagliaferri, G.; Roques, J. P.; Santangelo, A.


    The elucidation of key questions in astrophysics, in particular those related to black hole physics and census, and to particle acceleration mechanisms, necessitates to develop new observational capabilities in the hard X-ray domain with performances several orders of magnitude better than presently available. Relying on two spacecrafts in a formation flying configuration, Simbol-X will provide the world-wide astrophysics community with a single optics long focal length telescope. This observatory will have unrivaled performances in the hard X-ray domain, up to ∼80 keV, as well as very good characteristics in the soft X-ray domain, down to ∼0.5 keV. The Simbol-X mission has successfully passed a phase A study, jointly conducted by CNES and ASI, with the participation of German laboratories. It is now entering phase B studies with the participation of new international partners, for a launch in 2015. We give in this paper a general overview of the mission, as consolidated at the start of phase B.

  2. The Simbol-X Mission (United States)

    Ferrando, P.; Arnaud, M.; Briel, U.; Cavazzuti, E.; Clédassou, R.; Counil, J. L.; Fiore, F.; Giommi, P.; Goldwurm, A.; Lamarle, O.; Laurent, P.; Lebrun, F.; Malaguti, G.; Mereghetti, S.; Micela, G.; Pareschi, G.; Piermaria, M.; Roques, J. P.; Santangelo, A.; Tagliaferri, G.


    The elucidation of key questions in astrophysics, in particular those related to black hole physics and census, and to particle acceleration mechanisms, necessitates to develop new observational capabilities in the hard X-ray domain with performances several orders of magnitude better than presently available. Relying on two spacecrafts in a formation flying configuration, Simbol-X will provide the world-wide astrophysics community with a single optics long focal length telescope. This observatory will have unrivaled performances in the hard X-ray domain, up to ~80 keV, as well as very good characteristics in the soft X-ray domain, down to ~0.5 keV. The Simbol-X mission has successfully passed a phase A study, jointly conducted by CNES and ASI, with the participation of German laboratories. It is now entering phase B studies with the participation of new international partners, for a launch in 2015. We give in this paper a general overview of the mission, as consolidated at the start of phase B.

  3. Factor VIII (F8) inversions in severe hemophilia A: Male germ cell origin and diagnosis with RT-PCR

    Energy Technology Data Exchange (ETDEWEB)

    Antonarakis, S.E. [Geneva Medical School (Switzerland)]|[Johns Hopkins School of Medicine, Baltimore, MD (United States); Rossiter, J.P. [Johns Hopkins School of Medicine, Baltimore, MD (United States); Young, M. [Geneva Medical School (Switzerland)] [and others


    The Factor VIII (F8) gene, which is defective in hemophilia A, is located in the most telomeric megabase of Xq. Inversions due to intrachromosomal homologous recombination between mispaired copies of gene A located within intron 22 of the gene and about 500 kb telomeric to it account for nearly half of the cases of severe hemophilia A. We hypothesized that pairing of Xq with its homolog inhibits the inversion process, and that therefore the event originates predominantly in male germ cells. In all 21 informative cases in which the inversion originated in a maternal grandparent, DNA polymorphism analysis using markers within or very closely linked to F8, determined that it occurred in the male germline. In addition, all but one of 56 mothers of sporadic cases due to inversions were carriers. The data indicate that the F8 gene inversions leading to severe hemophilia A occur almost exclusively in male germ cells. The mean age of maternal grandfathers at the birth of their carrier daughters was 29.9 years (13 cases), i.e. not different from the mean paternal age in the general population, supporting the hypothesis that the inversions occur in meiosis. The inversions can be diagnosed by Southern blot analysis. For more rapid diagnosis we have used RT-PCR of RNA ectopically expressed in blood. Oligonucleotides were used to PCR amplify, after the initial RT reaction of RNA samples using random hexamers, either the normal transcript (F8 exons 21 to 24;312 bp product) or the novel abnormal transcript that is generated after the inversion. Both type 1 and 2 inversions can be recognized in affecteds and carriers by the presence of the diagnostic PcR product of 248 bp. Correct diagnoses were made in samples from 6 patients and 2 carriers with type 1 inversions, 2 patients and 2 carriers with type 2 inversions and 5 normal controls.

  4. Severe hemophilia A in a female by cryptic translocation: Order and orientation of factor VIII within Xq28

    Energy Technology Data Exchange (ETDEWEB)

    Migeon, B.R.; McGinniss, M.J.; Antonarakis, S.E.; Axelman, J.; Stasiowski, B.A.; Youssoufian, H.; Kearns, W.G.; Chung, A.; Pearson, P.L.; Kazazian, H.H. Jr. (Johns Hopkins Univ., Baltimore, MD (United States)); Muneer, R.S. (Univ. of Oklahoma, Norman (United States))


    The authors report studies of a female with severe hemophilia A resulting from a complex de novo translocation of chromosomes X and 17 (46,X,t(X; 17)). Somatic cell hybrids containing the normal X, the der(X), or the der(17) were analyzed for coagulation factor VIII (F8C) sequences using Southern blots and polymerase chain reaction. The normal X, always late replicating, contains a normal F8C gene, whereas the der(X) has no F8C sequences. The der(17) chromosome containing Xq24-Xq28 carries a functional G6PD locus and a deleted F8C allele that lacks exons 1--15. Also, it lacks the DXYS64-X locus, situated between the F8C locus and the Xq telomere. These results indicate that a cryptic breakpoint within Xq28 deleted the 5[prime] end of F8C, but left the more proximal G6PD locus intact on the der(17)chromosome. As the deleted segment includes the 5[prime] half of F8C as well as the subtelomeric DXYS64 locus, F8C must be oriented on the chromosome with its 5[prime] region closest to the telomere. Therefore, the order of these loci is Xcen-G6PD-3[prime]F8C-5[prime]F8C-DXYS64-Xqtel. The analysis of somatic cell hybrids has elucidated the true nature of the F8C mutation in the pro-band, revealing a more complex rearrangement (three chromosomes involved) than that expected from cytogenetic analysis, chromosome painting, and Southern blots. A 900-kb segment within Xq28 has been translocated to another autosome. Hemophilia A in this heterozygous female is due to the decapitation of the F8C gene on the der(17) and inactivation of the intact allele on the normal X. 27 refs., 5 figs., 1 tab.


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    Full Text Available The author examines the positive and negative effects of social media on the moral education of children in school SMPN 2 class VIII Banda Aceh, it is very interesting because of the many children who abuse social media. This work analyzes about the use of social media that have an impact on the moral education of children. The data collected in this study through the work of other literature, researchers also interviewed principals and students as many as 16 students as well as the observation at the school. Based on the analysis that has been done it can be seen the positive and negative impacts of the use of social media to the moral education of children. The positive impact on the social development of the media on moral education of children among children can adapt, socialize with the public and manage a network of friends, and make children easier to accomplish these tasks, while the negative impact of the development of social media to the moral education of children very much of them can make the omission in children so that children are less disciplined and be lazy, makes children easy to cheat the works of others, disrespectful both in dress and speech, often quarrel due to scenes that are as dangerous as scenes of pornography, violence, wars and so forth , as well as making children miss school because they feel more comfortable in the cafe of the study at the school, not only that social media also makes children spend pocket money a child so that the child took the money her parents secretly to access the internet cafe. Therefore, social media can lead education of children.

  6. Desmopressin acetate as a haemostatic elevator in individuals with combined deficiency of factors V and VIII: a clinical trial. (United States)

    Mansouritorghabeh, H; Shirdel, A


    ESSENTIALS: Combined factor V (FV) and factor VIII (FVIII) deficiency (CF5F8D) is an autosomal recessive coagulation disorder. Desmopressin acetate (DDAVP) was intravenously infused in 20 adult patients with CF5F8D. DDAVP can enhance FVIII levels but has no effect on FV levels in patients with CF5F8D. DDAVP can be substituted for FVIII concentrates in patients with CF5F8D. Combined factor V (FV) and FVIII deficiency (CF5F8D) is a rare inherited autosomal recessive double-gene disorder most frequently seen in the Middle East. Although affected individuals have deficiency of two coagulation factors (range 5-30%), their bleeding tendencies are similar to patients who have deficiency of a single coagulation factor at the same level. The mainstay of their treatment is infusion of FVIII concentrate and fresh frozen plasma. Here, the effect of intravenous infusion of desmopressin acetate (DDAVP) on elevation of coagulation FV and FVIII was investigated through a clinical trial in May 2015. In a registered controlled trial, DDAVP (dosage 0.3 μg kg(-1) ) was intravenously infused into 20 adult patients with CF5F8D over 20 min. After an hour, blood samples were collected and plasma levels of FV and FVIII were measured. This study revealed that DDAVP can enhance FVIII levels but has no effect on FV plasma concentration in patients with CF5F8D. Based on these findings, FVIII concentrates may be substituted for DDAVP in patients with CF5F8D. © 2015 International Society on Thrombosis and Haemostasis.

  7. Affinity for a malignant tumor and organs at the elements in group VIII of the periodic table

    International Nuclear Information System (INIS)

    Ando, Atsushi; Hisada, Kinichi; Ando, Itsuko.


    In order to investigate the tumor affinity of the radioisotopes, iron(Fe-59), cobalt(Co-58), ruthenium(Ru-103), palladium(Pd-103), osmium(Os-185+191) and iridium(Ir-192), the elements of group VIII in the periodic table were examined, using rats which were subcutaneously transplanted with Yoshida sarcoma. Six preparations, 59 Fe-chloride, 58 Co-chloride, 103 Ru-chloride, 103 Pd-chloride, 185+191 Os-hexachlorosmic acid and 192 Ir-hexachloriridic acid were injected intravenously in to each group of tumor bearing rats. These rats were sacrificed at various periods after injection of each preparation: 3 hours, 24 hours and 48 hours in all preparations, except 59 Fe-chloride with 30 minutes, 3 hours, 24 hours and 48 hours. The radioactivities of the tumor, blood muscle, liver, kidney and spleen were measured by a well-type scintillation counter, and retention values (in every tissue including the tumor were calculated in percent of administered dose per g-tissue weight). 185+191 Os-hexachlorosmic acid had a considerably strong affinity for the malignant tumor. 59 Fe-chloride, 58 Co-chloride, 103 Ru-chloride, 103 Pd-chloride and 192 Ir-hexachloriridic acid did not have any affinity for the malignant tumor. However 59 Fe-chloride had a very strong affinity for blood corpuscles. 103 Pd-chloride had a fairly strong affinity for the kidney and liver, 58 Co-chloride had a fairly affinity for the liver, 103 Ru-chloride, 185+191 Os-hexachlorosmic acid and 192 Ir-hexachloriridic acid had a fairly strong affinity for the kidney. (Evans, J.)

  8. Relationship between ABO blood groups and von Willebrand factor, ADAMTS13 and factor VIII in patients undergoing hemodialysis. (United States)

    Rios, Danyelle R A; Fernandes, Ana Paula; Figueiredo, Roberta C; Guimarães, Daniela A M; Ferreira, Cláudia N; Simões E Silva, Ana C; Carvalho, Maria G; Gomes, Karina B; Dusse, Luci Maria Sant' Ana


    Several studies have demonstrated that non-O blood groups subjects present an increased VTE risk as compared to those carrying O blood group. The aim of this study was to investigate the ABO blood groups influence on factor VIII (FVIII) activity, von Willebrand factor (VWF), and ADAMTS13 plasma levels in patients undergoing hemodialysis (HD). Patients undergoing HD (N=195) and 80 healthy subjects (control group) were eligible for this cross-sectional study. The ABO blood group phenotyping was performed by the reverse technique. FVIII activity was measured through coagulometric method, and VWF and ADAMTS13 antigens were assessed by ELISA. FVIII activity and VWF levels were significantly higher and ADAMTS13 levels was decreased in HD patients, as compared to healthy subjects (P blood groups showed a significant increase in FVIII activity (P = 0.001) and VWF levels (P blood group. However, no significant difference was observed in ADAMTS13 levels (P = 0.767). In the control group, increased in FVIII activity (P = 0.001) and VWF levels (P = 0.002) and decreased in ADAMTS13 levels (P = 0.005) were observed in subjects carrying non-O blood groups as compared to carriers of O blood group.Our data confirmed that ABO blood group is an important risk factor for increased procoagulant factors in plasma, as FVIII and VWF. Admitting the possible role of kidneys in ADAMTS13 synthesis or on its metabolism, HD patients were not able to increase ADAMTS13 levels in order to compensate the increase of VWF levels mediated by ABO blood groups. Considering that non-O blood groups constitute a risk factor for thrombosis, it is reasonable to admit that A, B and AB HD patients need a careful and continuous follow-up in order to minimize thrombotic events.

  9. Association of ABO blood groups with von Willebrand factor, factor VIII and ADAMTS-13 in patients with lung cancer. (United States)

    Liu, Xia; Chen, Xiaogang; Yang, Jiezuan; Guo, Renyong


    Coagulative and fibrinolytic disorders appear to be associated with the development of lung cancer. The aim of the present study was to determine plasma levels of von Willebrand factor (VWF) and a disintegrin and metalloproteinase with a thrombospondin type 1 motif 13 (ADAMTS-13), and factor VIII (FVIII) activity, in association with O and non-O blood groups in patients with lung cancer. Plasma levels of VWF and ADAMTS-13, and FVIII activity were measured in 115 patients with lung cancer and 98 healthy subjects. Phenotyping of the ABO blood groups was also performed for the two groups. Significantly increased VWF levels and FVIII activity, as well as significantly decreased ADAMTS-13 levels, were observed in patients with distant metastasis as compared with those without distant metastasis and the healthy controls. Plasma VWF levels and FVIII activity were significantly increased in subjects with non-O type blood compared with those with type O blood in the two groups. However, a significant decrease in ADAMTS-13 levels was observed only in the control group among those with non-O type blood, compared with those with type O blood. The results of the present study indicate that increased VWF and decreased ADAMTS-13 levels facilitate the invasiveness and metastasis of lung cancer. Non-O blood groups constitute a risk factor for increased VWF and FVIII in plasma. Continued monitoring of VWF and ADAMTS-13 levels, and of FVIII activity in patients with lung cancer with distinct blood groups may help to minimize the incidence of thrombotic events and improve assessment of disease progression.

  10. Storage of factor VIII variants with impaired von Willebrand factor binding in Weibel-Palade bodies in endothelial cells.

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    Maartje van den Biggelaar

    Full Text Available BACKGROUND: Point mutations resulting in reduced factor VIII (FVIII binding to von Willebrand factor (VWF are an important cause of mild/moderate hemophilia A. Treatment includes desmopressin infusion, which concomitantly increases VWF and FVIII plasma levels, apparently from storage pools containing both proteins. The source of these VWF/FVIII co-storage pools and the mechanism of granule biogenesis are not fully understood. METHODOLOGY/PRINCIPAL FINDINGS: We studied intracellular trafficking of FVIII variants implicated in mild/moderate hemophilia A together with VWF in HEK293 cells and primary endothelial cells. The role of VWF binding was addressed using FVIII variants displaying reduced VWF interaction. Binding studies using purified FVIII proteins revealed moderate (Arg2150His, Del2201, Pro2300Ser to severe (Tyr1680Phe, Ser2119Tyr VWF binding defects. Expression studies in HEK293 cells and primary endothelial cells revealed that all FVIII variants were present within VWF-containing organelles. Quantitative studies showed that the relative amount of FVIII storage was independent of various mutations. Substantial amounts of FVIII variants are co-stored in VWF-containing storage organelles, presumably by virtue of their ability to interact with VWF at low pH. CONCLUSIONS: Our data suggest that the potential of FVIII co-storage with VWF is not affected in mild/moderate hemophilia A caused by reduced FVIII/VWF interaction in the circulation. These data support the hypothesis that Weibel-Palade bodies comprise the desmopressin-releasable FVIII storage pool in vivo.

  11. Transient B cell depletion or improved transgene expression by codon optimization promote tolerance to factor VIII in gene therapy.

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    Brandon K Sack

    Full Text Available The major complication in the treatment of hemophilia A is the development of neutralizing antibodies (inhibitors against factor VIII (FVIII. The current method for eradicating inhibitors, termed immune tolerance induction (ITI, is costly and protracted. Clinical protocols that prevent rather than treat inhibitors are not yet established. Liver-directed gene therapy hopes to achieve long-term correction of the disease while also inducing immune tolerance. We sought to investigate the use of adeno-associated viral (serotype 8 gene transfer to induce tolerance to human B domain deleted FVIII in hemophilia A mice. We administered an AAV8 vector with either human B domain deleted FVIII or a codon-optimized transgene, both under a liver-specific promoter to two strains of hemophilia A mice. Protein therapy or gene therapy was given either alone or in conjunction with anti-CD20 antibody-mediated B cell depletion. Gene therapy with a low-expressing vector resulted in sustained near-therapeutic expression. However, supplementary protein therapy revealed that gene transfer had sensitized mice to hFVIII in a high-responder strain but not in mice of a low-responding strain. This heightened response was ameliorated when gene therapy was delivered with anti-murine CD20 treatment. Transient B cell depletion prevented inhibitor formation in protein therapy, but failed to achieve a sustained hypo-responsiveness. Importantly, use of a codon-optimized hFVIII transgene resulted in sustained therapeutic expression and tolerance without a need for B cell depletion. Therefore, anti-CD20 may be beneficial in preventing vector-induced immune priming to FVIII, but higher levels of liver-restricted expression are preferred for tolerance.


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    Noni Eka Jaya Wardani


    Full Text Available 800x600 Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 The cross sectional design was used in this study to elaborate physical activity, energy consumption, and work productivity of men workers. The total number of sample is 72 men.  The inclusion criteria of  the sample is the head of household’s women tea pickers at Tea Plantation PTPN VIII Bandung, West Java who have children 0-72 month age and willing to be interviewed. The place of the research was chose purposively. Malabar Plantation was chosen from the other five plantations (clusters cause of its easier access and the homogenous characteristics inter cluster. Data collected was analyzed statistically. In general, more than a half of samples had  active or moderately physical activity  level (PAL=1.89. The physical activity level of samples during work day (average PAL=1.93 was higher than holiday (average PAL=1.77 (p87.2 - 121.2%.  Majority of samples (76.4% had wages per month below the regional minimum wages. The working hours of more than a half of samples were below seven hours per day and had wages per hour below standard regional minimum wage. Based on correlation analysis, there are significant correlation between 1 education level with physical activity level; 2 age, income per capita, and family size with wage per month; 3 age and physical activity level with working hours; and 4 age and  income per capita with wages per hour. Keywords:  physical activity, energy expenditure, energy   adequacy level, work productivity, tea picker’s household   head.

  13. The Comet Radar Explorer Mission (United States)

    Asphaug, Erik; Belton, Mike; Bockelee-Morvan, Dominique; Chesley, Steve; Delbo, Marco; Farnham, Tony; Gim, Yonggyu; Grimm, Robert; Herique, Alain; Kofman, Wlodek; Oberst, Juergen; Orosei, Roberto; Piqueux, Sylvain; Plaut, Jeff; Robinson, Mark; Sava, Paul; Heggy, Essam; Kurth, William; Scheeres, Dan; Denevi, Brett; Turtle, Elizabeth; Weissman, Paul


    Missions to cometary nuclei have revealed major geological surprises: (1) Global scale layers - do these persist through to the interior? Are they a record of primary accretion? (2) Smooth regions - are they landslides originating on the surface? Are they cryovolcanic? (3) Pits - are they impact craters or sublimation pits, or rooted in the interior? Unambiguous answers to these and other questions can be obtained by high definition 3D radar reflection imaging (RRI) of internal structure. RRI can answer many of the great unknowns in planetary science: How do primitive bodies accrete? Are cometary nuclei mostly ice? What drives their spectacular activity and evolution? The Comet Radar Explorer (CORE) mission will image the detailed internal structure of the nucleus of 10P/Tempel 2. This ~16 x 8 x 7 km Jupiter Family Comet (JFC), or its parent body, originated in the outer planets region possibly millions of years before planet formation. CORE arrives post-perihelion and observes the comet’s waning activity from safe distance. Once the nucleus is largely dormant, the spacecraft enters a ~20-km dedicated Radar Mapping Orbit (RMO). The exacting design of the RRI experiment and the precise navigation of RMO will achieve a highly focused 3D radar reflection image of internal structure, to tens of meters resolution, and tomographic images of velocity and attenuation to hundreds of meters resolution, tied to the gravity model and shape. Visible imagers will produce maps of the surface morphology, albedo, color, texture, and photometric response, and images for navigation and shape determination. The cameras will also monitor the structure and dynamics of the coma, and its dusty jets, allowing their correlation in 3D with deep interior structures and surface features. Repeated global high-resolution thermal images will probe the near-surface layers heated by the Sun. Derived maps of thermal inertia will be correlated with the radar boundary response, and photometry and

  14. Austere Human Missions to Mars (United States)

    Price, Hoppy; Hawkins, Alisa M.; Tadcliffe, Torrey O.


    The Design Reference Architecture 5 (DRA 5) is the most recent concept developed by NASA to send humans to Mars in the 2030 time frame using Constellation Program elements. DRA 5 is optimized to meet a specific set of requirements that would provide for a robust exploration program to deliver a new six-person crew at each biennial Mars opportunity and provide for power and infrastructure to maintain a highly capable continuing human presence on Mars. This paper examines an alternate architecture that is scaled back from DRA 5 and might offer lower development cost, lower flight cost, and lower development risk. It is recognized that a mission set using this approach would not meet all the current Constellation Mars mission requirements; however, this 'austere' architecture may represent a minimum mission set that would be acceptable from a science and exploration standpoint. The austere approach is driven by a philosophy of minimizing high risk or high cost technology development and maximizing development and production commonality in order to achieve a program that could be sustained in a flat-funded budget environment. Key features that would enable a lower technology implementation are as follows: using a blunt-body entry vehicle having no deployable decelerators, utilizing aerobraking rather than aerocapture for placing the crewed element into low Mars orbit, avoiding the use of liquid hydrogen with its low temperature and large volume issues, using standard bipropellant propulsion for the landers and ascent vehicle, and using radioisotope surface power systems rather than a nuclear reactor or large area deployable solar arrays. Flat funding within the expected NASA budget for a sustained program could be facilitated by alternating cargo and crew launches for the biennial Mars opportunities. This would result in two assembled vehicles leaving Earth orbit for Mars per Mars opportunity. The first opportunity would send two cargo landers to the Mars surface to

  15. Enabling the First Interstellar Missions (United States)

    Lubin, P.


    All propulsion systems that leave the Earth are based on chemical reactions. Chemical reactions, at best, have an efficiency compared to rest mass of 10-10 (or about 1eV per bond). All the mass in the universe converted to chemical reactions would not propel even a single proton to relativistic speeds. While chemistry will get us to Mars it will not allow interstellar capability in any reasonable mission time. Barring new physics we are left with few realistic solutions. None of our current propulsion systems, including nuclear, are capable of the relativistic speeds needed for exploring the many nearby stellar systems and exo-planets. However recent advances in photonics and directed energy systems now allow us to realize what was only a decade ago, simply science fiction, namely the ability to seriously conceive of and plan for relativistic flight. From fully-functional gram-level wafer-scale spacecraft capable of speeds greater than c/4 that could reach the nearest star in 20 years to spacecraft for large missions capable of supporting human life with masses more than 105 kg (100 tons) for rapid interplanetary transit that could reach speeds of greater than 1000 km/s can be realized. With this technology spacecraft can be propelled to speeds currently unimaginable. Photonics, like electronics, and unlike chemical propulsion is an exponential technology with a current double time of about 20 months. This is the key. The cost of such a system is amortized over the essentially unlimited number of launches. In addition, the same photon driver can be used for many other purposes including beamed energy to power high Isp ion engines, remote asteroid composition analysis and planetary defense. This would be a profound change in human capability with enormous implications. Known as Starlight we are now in a NASA Phase II study. The FY 2017 congressional appropriations request directs NASA to study the feasibility of an interstellar mission to coincide with the 100th

  16. The draft Mission Plan Amendment

    International Nuclear Information System (INIS)

    Gale, R.W.


    The draft Mission Plan Amendment provides an opportunity for States and Indian Tribes and other involved parties to participate in a process that no other nation affords its citizens. More than just a comment period on a Department of Energy document, the amendment that is to be submitted later this year will lay before Congress, the documentary basis on which to make decisions about the scope and timing of the high-level waste program in what Secretary Herrington has called a ''crossroads'' years. The Amendment will distill the view of the participants and also preset them to Congress as an integral part of the document. After four years of effort, the Nation is being afforded an opportunity to ask itself again whether the Act passed in 1982 is working and remains the best way to protect the public interest

  17. JUICE space mission to Jupiter

    CERN Document Server

    CERN. Geneva


    JUICE - JUpiter ICy moons Explorer - is the first large-class mission in ESA's Cosmic Vision 2015-2025 programme. Planned for launch in 2022 and arrival at Jupiter in 2029, it will spend at least three years making detailed observations of the giant gaseous planet Jupiter and three of its largest moons, Ganymede, Callisto and Europa. JUICE will perform detailed investigations of Jupiter and its system in all their inter-relations and complexity with particular emphasis on Ganymede as a planetary body and potential habitat. Investigations of Europa and Callisto would complete a comparative picture of the Galilean moons. Jupiter is the archetype for the giant planets of the Solar System and for the numerous giant planets now known to orbit other stars. Moreover, Jupiter's diverse Galilean satellites - three of which are believed to harbour internal oceans - are central to understanding the habitability of icy worlds. JUICE spacecraft will carry the most powerful remote sensing, geophysical, and in situ paylo...

  18. The Mission Operations Planning Assistant (United States)

    Schuetzle, James G.


    The Mission Operations Planning Assistant (MOPA) is a knowledge-based system developed to support the planning and scheduling of instrument activities on the Upper Atmospheric Research Satellite (UARS). The MOPA system represents and maintains instrument plans at two levels of abstraction in order to keep plans comprehensible to both UARS Principal Investigators and Command Management personnel. The hierarchical representation of plans also allows MOPA to automatically create detailed instrument activity plans from which spacecraft command loads may be generated. The MOPA system was developed on a Symbolics 3640 computer using the ZetaLisp and ART languages. MOPA's features include a textual and graphical interface for plan inspection and modification, recognition of instrument operational constraint violations during the planning process, and consistency maintenance between the different planning levels. This paper describes the current MOPA system.

  19. Cassini Mission Sequence Subsystem (MSS) (United States)

    Alland, Robert


    This paper describes my work with the Cassini Mission Sequence Subsystem (MSS) team during the summer of 2011. It gives some background on the motivation for this project and describes the expected benefit to the Cassini program. It then introduces the two tasks that I worked on - an automatic system auditing tool and a series of corrections to the Cassini Sequence Generator (SEQ_GEN) - and the specific objectives these tasks were to accomplish. Next, it details the approach I took to meet these objectives and the results of this approach, followed by a discussion of how the outcome of the project compares with my initial expectations. The paper concludes with a summary of my experience working on this project, lists what the next steps are, and acknowledges the help of my Cassini colleagues.

  20. Hummingbird Comet Nucleus Analysis Mission (United States)

    Kojiro, Daniel; Carle, Glenn C.; Lasher, Larry E.


    Hummingbird is a highly focused scientific mission, proposed to NASA s Discovery Program, designed to address the highest priority questions in cometary science-that of the chemical composition of the cometary nucleus. After rendezvous with the comet, Hummingbird would first methodically image and map the comet, then collect and analyze dust, ice and gases from the cometary atmosphere to enrich characterization of the comet and support landing site selection. Then, like its namesake, Hummingbird would carefully descend to a pre-selected surface site obtaining a high-resolution image, gather a surface material sample, acquire surface temperature and then immediately return to orbit for detailed chemical and elemental analyses followed by a high resolution post-sampling image of the site. Hummingbird s analytical laboratory contains instrumentation for a comprehensive molecular and elemental analysis of the cometary nucleus as well as an innovative surface sample acquisition device.

  1. LISA Pathfinder: A Mission Status (United States)

    Hewitson, Martin; LISA Pathfinder Team Team


    On December 3rd at 04:04 UTC, The European Space Agency launched the LISA Pathfinder satellite on board a VEGA rocket from Kourou in French Guiana. After a series of orbit raising manoeuvres and a 2 month long transfer orbit, LISA Pathfinder arrived at L1. Following a period of commissioning, the science operations commenced at the start of March, beginning the demonstration of technologies and methodologies which pave the way for a future large-scale gravitational wave observatory in space. This talk will present the scientific goals of the mission, discuss the technologies being tested, elucidate the link to a future space-based observatory, such as LISA, and present preliminary results from the in-orbit operations and experiments.


    Directory of Open Access Journals (Sweden)

    Mario Bertaina


    Full Text Available The JEM-EUSO mission explores the origin of the extreme energy cosmic rays (EECRs above 50EeV and explores the limits of the fundamental physics, through the observations of their arrival directions and energies. It is designed to open a new particle astronomy channel. This superwide-field (60 degrees telescope with a diameter of about 2.5m looks down from space onto the night sky to detect near UV photons (330 ÷ 400nm, both fluorescent and Cherenkov photons emitted from the giant air showers produced by EECRs. The arrival direction map with more than five hundred events will tell us the origin of the EECRs and allow us to identify the nearest EECR sources with known astronomical objects. It will allow them to be examined in other astronomical channels. This is likely to lead to an  nderstanding of the acceleration mechanisms perhaps producing discoveries in astrophysics and/or fundamental physics. The comparison of the energy spectra among the spatially resolved individual sources will help to clarify the acceleration/emission mechanism, and also finally confirm the Greisen–Zatsepin–Kuz’min process for the validation of Lorentz invariance up to γ ~ 1011. Neutral components (neutrinos and gamma rays can also be detected as well, if their fluxes are high enough. The JEM-EUSO mission is planned to be launched by a H2B rocket about 2017 and transferred to ISS by H2 Transfer Vehicle (HTV. It will be attached to the Exposed Facility external experiment platform of “KIBO”.

  3. Orbit determination for ISRO satellite missions (United States)

    Rao, Ch. Sreehari; Sinha, S. K.

    Indian Space Research Organisation (ISRO) has been successful in using the in-house developed orbit determination and prediction software for satellite missions of Bhaskara, Rohini and APPLE. Considering the requirements of satellite missions, software packages are developed, tested and their accuracies are assessed. Orbit determination packages developed are SOIP, for low earth orbits of Bhaskara and Rohini missions, ORIGIN and ODPM, for orbits related to all phases of geo-stationary missions and SEGNIP, for drift and geo-stationary orbits. Software is tested and qualified using tracking data of SIGNE-3, D5-B, OTS, SYMPHONIE satellites with the help of software available with CNES, ESA and DFVLR. The results match well with those available from these agencies. These packages have supported orbit determination successfully throughout the mission life for all ISRO satellite missions. Member-Secretary

  4. The PROPEL Electrodynamic Tether Demonstration Mission (United States)

    Bilen, Sven G.; Johnson, C. Les; Wiegmann, Bruce M.; Alexander, Leslie; Gilchrist, Brian E.; Hoyt, Robert P.; Elder, Craig H.; Fuhrhop, Keith P.; Scadera, Michael


    The PROPEL ("Propulsion using Electrodynamics") mission will demonstrate the operation of an electrodynamic tether propulsion system in low Earth orbit and advance its technology readiness level for multiple applications. The PROPEL mission has two primary objectives: first, to demonstrate the capability of electrodynamic tether technology to provide robust and safe, near-propellantless propulsion for orbit-raising, de-orbit, plane change, and station keeping, as well as to perform orbital power harvesting and formation flight; and, second, to fully characterize and validate the performance of an integrated electrodynamic tether propulsion system, qualifying it for infusion into future multiple satellite platforms and missions with minimal modification. This paper provides an overview of the PROPEL system and design reference missions; mission goals and required measurements; and ongoing PROPEL mission design efforts.

  5. Spacelab Mission Implementation Cost Assessment (SMICA) (United States)

    Guynes, B. V.


    A total savings of approximately 20 percent is attainable if: (1) mission management and ground processing schedules are compressed; (2) the equipping, staffing, and operating of the Payload Operations Control Center is revised, and (3) methods of working with experiment developers are changed. The development of a new mission implementation technique, which includes mission definition, experiment development, and mission integration/operations, is examined. The Payload Operations Control Center is to relocate and utilize new computer equipment to produce cost savings. Methods of reducing costs by minimizing the Spacelab and payload processing time during pre- and post-mission operation at KSC are analyzed. The changes required to reduce costs in the analytical integration process are studied. The influence of time, requirements accountability, and risk on costs is discussed. Recommendation for cost reductions developed by the Spacelab Mission Implementation Cost Assessment study are listed.

  6. Missions and planning for nuclear space power

    International Nuclear Information System (INIS)

    Buden, D.


    Requirements for electrical and propulsion power for space are expected to increase dramatically in the 1980s. Nuclear power is probably the only source for some deep space missions and a major competitor for many orbital missions, especially those at geosynchronous orbit. Because of the potential requirements, a technology program on reactor components has been initiated by the Department of Energy. The missions that are foreseen, the current reactor concept, and the technology program plan are described

  7. GSFC Safety and Mission Assurance Organization (United States)

    Kelly, Michael P.


    This viewgraph presentation reviews NASA Goddard Space Flight Center's approach to safety and mission assurance. The contents include: 1) NASA GSFC Background; 2) Safety and Mission Assurance Directorate; 3) The Role of SMA-D and the Technical Authority; 4) GSFC Mission assurance Requirements; 5) GSFC Systems Review Office (SRO); 6) GSFC Supply Chain Management Program; and 7) GSFC ISO9001/AS9100 Status Brief.

  8. Component Verification and Certification in NASA Missions (United States)

    Giannakopoulou, Dimitra; Penix, John; Norvig, Peter (Technical Monitor)


    Software development for NASA missions is a particularly challenging task. Missions are extremely ambitious scientifically, have very strict time frames, and must be accomplished with a maximum degree of reliability. Verification technologies must therefore be pushed far beyond their current capabilities. Moreover, reuse and adaptation of software architectures and components must be incorporated in software development within and across missions. This paper discusses NASA applications that we are currently investigating from these perspectives.

  9. Mission Reliability Estimation for Repairable Robot Teams (United States)

    Trebi-Ollennu, Ashitey; Dolan, John; Stancliff, Stephen


    A mission reliability estimation method has been designed to translate mission requirements into choices of robot modules in order to configure a multi-robot team to have high reliability at minimal cost. In order to build cost-effective robot teams for long-term missions, one must be able to compare alternative design paradigms in a principled way by comparing the reliability of different robot models and robot team configurations. Core modules have been created including: a probabilistic module with reliability-cost characteristics, a method for combining the characteristics of multiple modules to determine an overall reliability-cost characteristic, and a method for the generation of legitimate module combinations based on mission specifications and the selection of the best of the resulting combinations from a cost-reliability standpoint. The developed methodology can be used to predict the probability of a mission being completed, given information about the components used to build the robots, as well as information about the mission tasks. In the research for this innovation, sample robot missions were examined and compared to the performance of robot teams with different numbers of robots and different numbers of spare components. Data that a mission designer would need was factored in, such as whether it would be better to have a spare robot versus an equivalent number of spare parts, or if mission cost can be reduced while maintaining reliability using spares. This analytical model was applied to an example robot mission, examining the cost-reliability tradeoffs among different team configurations. Particularly scrutinized were teams using either redundancy (spare robots) or repairability (spare components). Using conservative estimates of the cost-reliability relationship, results show that it is possible to significantly reduce the cost of a robotic mission by using cheaper, lower-reliability components and providing spares. This suggests that the

  10. Cryogenic propulsion for lunar and Mars missions (United States)

    Redd, Larry


    Future missions to the moon and Mars have been investigated with regard to propulsion system selection. The results of this analysis show that near state-of-the-art LO2/LH2 propulsion technology provides a feasible means of performing lunar missions and trans-Mars injections. In other words, existing cryogenic space engines with certain modifications and product improvements would be suitable for these missions. In addition, present day cryogenic system tankage and structural weights appear to scale reasonably when sizing for large payload and high energy missions such as sending men to Mars.

  11. LISA Mission and System architectures and performances

    International Nuclear Information System (INIS)

    Gath, Peter F; Weise, Dennis; Schulte, Hans-Reiner; Johann, Ulrich


    In the context of the LISA Mission Formulation Study, the LISA System was studied in detail and a new baseline architecture for the whole mission was established. This new baseline is the result of trade-offs on both, mission and system level. The paper gives an overview of the different mission scenarios and configurations that were studied in connection with their corresponding advantages and disadvantages as well as performance estimates. Differences in the required technologies and their influence on the overall performance budgets are highlighted for all configurations. For the selected baseline concept, a more detailed description of the configuration is given and open issues in the technologies involved are discussed.

  12. LISA Mission and System architectures and performances

    Energy Technology Data Exchange (ETDEWEB)

    Gath, Peter F; Weise, Dennis; Schulte, Hans-Reiner; Johann, Ulrich, E-mail: [Astrium GmbH Satellites, 88039 Friedrichshafen (Germany)


    In the context of the LISA Mission Formulation Study, the LISA System was studied in detail and a new baseline architecture for the whole mission was established. This new baseline is the result of trade-offs on both, mission and system level. The paper gives an overview of the different mission scenarios and configurations that were studied in connection with their corresponding advantages and disadvantages as well as performance estimates. Differences in the required technologies and their influence on the overall performance budgets are highlighted for all configurations. For the selected baseline concept, a more detailed description of the configuration is given and open issues in the technologies involved are discussed.

  13. NASA Laboratory Analysis for Manned Exploration Missions (United States)

    Krihak, Michael K.; Shaw, Tianna E.


    The Exploration Laboratory Analysis (ELA) project supports the Exploration Medical Capability Element under the NASA Human Research Program. ELA instrumentation is identified as an essential capability for future exploration missions to diagnose and treat evidence-based medical conditions. However, mission architecture limits the medical equipment, consumables, and procedures that will be available to treat medical conditions during human exploration missions. Allocated resources such as mass, power, volume, and crew time must be used efficiently to optimize the delivery of in-flight medical care. Although commercial instruments can provide the blood and urine based measurements required for exploration missions, these commercial-off-the-shelf devices are prohibitive for deployment in the space environment. The objective of the ELA project is to close the technology gap of current minimally invasive laboratory capabilities and analytical measurements in a manner that the mission architecture constraints impose on exploration missions. Besides micro gravity and radiation tolerances, other principal issues that generally fail to meet NASA requirements include excessive mass, volume, power and consumables, and nominal reagent shelf-life. Though manned exploration missions will not occur for nearly a decade, NASA has already taken strides towards meeting the development of ELA medical diagnostics by developing mission requirements and concepts of operations that are coupled with strategic investments and partnerships towards meeting these challenges. This paper focuses on the remote environment, its challenges, biomedical diagnostics requirements and candidate technologies that may lead to successful blood-urine chemistry and biomolecular measurements in future space exploration missions.

  14. Space Mission Human Reliability Analysis (HRA) Project (United States)

    Boyer, Roger


    The purpose of the Space Mission Human Reliability Analysis (HRA) Project is to extend current ground-based HRA risk prediction techniques to a long-duration, space-based tool. Ground-based HRA methodology has been shown to be a reasonable tool for short-duration space missions, such as Space Shuttle and lunar fly-bys. However, longer-duration deep-space missions, such as asteroid and Mars missions, will require the crew to be in space for as long as 400 to 900 day missions with periods of extended autonomy and self-sufficiency. Current indications show higher risk due to fatigue, physiological effects due to extended low gravity environments, and others, may impact HRA predictions. For this project, Safety & Mission Assurance (S&MA) will work with Human Health & Performance (HH&P) to establish what is currently used to assess human reliabiilty for human space programs, identify human performance factors that may be sensitive to long duration space flight, collect available historical data, and update current tools to account for performance shaping factors believed to be important to such missions. This effort will also contribute data to the Human Performance Data Repository and influence the Space Human Factors Engineering research risks and gaps (part of the HRP Program). An accurate risk predictor mitigates Loss of Crew (LOC) and Loss of Mission (LOM).The end result will be an updated HRA model that can effectively predict risk on long-duration missions.

  15. Possible LISA Technology Applications for Other Missions (United States)

    Livas, Jeffrey


    The Laser Interferometer Space Antenna (LISA) has been selected as the third large class mission launch opportunity of the Cosmic Visions Program by the European Space Agency (ESA). LISA science will explore a rich spectrum of astrophysical gravitational-wave sources expected at frequencies between 0.0001 and 0.1 Hz and complement the work of other observatories and missions, both space and ground-based, electromagnetic and non-electromagnetic. Similarly, LISA technology may find applications for other missions. This paper will describe the capabilities of some of the key technologies and discuss possible contributions to other missions.

  16. Flexible UAV Mission Management Using Emerging Technologies

    National Research Council Canada - National Science Library

    Desimone, Roberto; Lee, Richard


    This paper discusses recent results and proposed work in the application of emerging artificial intelligence technologies for flexible mission management, especially for unmanned (combat) airborne vehicles...

  17. [The mission of Princeton Plasma Physics Laboratory

    International Nuclear Information System (INIS)


    This report discusses the following about Princeton Plasma Physics Laboratory: its mission; requirements and guidance documents for the QA program; architecture; assessment organization; and specific management issues

  18. Cassini Solstice Mission Maneuver Experience: Year Two (United States)

    Arrieta, Juan; Ballard, Christopher G.; Hahn, Yungsun


    The Cassini Spacecraft was launched in October 1997 on a mission to observe Saturn and its moons; it entered orbit around Saturn in July 2004 for a nominal four-year Prime Mission, later augmented by two extensions: the Equinox Mission, from July 2008 through September 2010, and the Solstice Mission, from October 2010 through September 2017. This paper provides an overview of the maneuver activities from August 2011 through June 2012 which include the design of 38 Orbit Trim Maneuvers--OTM-288 through OTM-326-- for attaining 14 natural satellite encounters: seven with Titan, six with Enceladus, and one with Dione.

  19. Sustainable, Reliable Mission-Systems Architecture (United States)

    O'Neil, Graham; Orr, James K.; Watson, Steve


    A mission-systems architecture, based on a highly modular infrastructure utilizing: open-standards hardware and software interfaces as the enabling technology is essential for affordable and sustainable space exploration programs. This mission-systems architecture requires (a) robust communication between heterogeneous system, (b) high reliability, (c) minimal mission-to-mission reconfiguration, (d) affordable development, system integration, and verification of systems, and (e) minimal sustaining engineering. This paper proposes such an architecture. Lessons learned from the Space Shuttle program and Earthbound complex engineered system are applied to define the model. Technology projections reaching out 5 years are mde to refine model details.

  20. Rapid Automated Mission Planning System, Phase II (United States)

    National Aeronautics and Space Administration — The proposed innovation is an automated UAS mission planning system that will rapidly identify emergency (contingency) landing sites, manage contingency routing, and...

  1. Lessons learned from IAEA fire safety missions

    International Nuclear Information System (INIS)

    Lee, S.P.


    The IAEA has conducted expert missions to evaluate fire safety at the following nuclear power plants: the Zaporozhe plant in the Ukraine, the Borselle plant in the Netherlands, the Medzamor plant in Armenia, the Karachi plant in Pakistan, the Temelin plant in the Czech Republic, and the Laguna Verde plant in Mexico. The scope of these missions varied in subject and depth. The teams sent from the IAEA consisted of external fire experts and IAEA staff. All the missions were of great use to the host countries. The participating experts also benefited significantly. A summary of the missions and their findings is given. (author)

  2. Estudo citofotométrico da expressão do marcador tumoral Fator VIII e fatores prognósticos no adenocarcinoma gástrico Cytophotometric study of the expression of the tumoral marker Factor VIII and prognostic factors in gastrci adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Mary Tossa Nakamura


    Full Text Available RACIONAL: No câncer gástrico, a incidência, o diagnóstico e as opções terapêuticas apresentaram melhorias nas últimas décadas, porém o prognóstico permanece reservado, especialmente devido à maioria dos pacientes procurarem recurso médico com tumores avançados, metastáticos ou cirurgicamente irressecáveis já no diagnóstico. Biologia molecular é área de conhecimento recente com grandes questionamentos a serem respondidos e a atualidade dos fatos científicos mostra que o caminho deverá ser através da identificação de marcadores tumorais. Os grandes avanços na área da informática aprimoraram a análise da imagem celular através da citofotometria de imagem que possibilita através da imunoistoquímica estudar a proliferação celular e a angiogênese que participa em diversos processos tumorais, sendo pesquisadas por vários marcadores. Atualmente estudos são realizados para demonstrar o valor prognóstico de suas expressões, contudo, no adenocarcinoma gástrico resultados têm sido divergentes e estudos escassos. OBJETIVOS: Identificar e quantificar citofotometricamente a expressão dos marcadores da angiogênese através do fator VIII no adenocarcinoma e comparar suas expressões com fa classificação de Bormann, profundidade de invasão tumoral, grau de diferenciação, envolvimento nodal, padrão histológico e idade. MÉTODOS: Foram estudados 21 pacientes com adenocarcinoma gástrico, identificados de 1998 a 2006. Para a detecção do Fator VIII foi realizada imunoistoquímica, com anticorpo policlonal para Fator VIII. Foi realizada análise citofotométrica informatizada pelo sistema SAMBA 4000. RESULTADOS: Dos 21 pacientes 61,90% eram do sexo masculino e 38,10% do feminino, com idade mediana de 65 anos e apenas um não marcou para o Fator VIII (95,24% de marcação. As médias dos índices de marcagem para o Fator VIII foram de 61,14% (desvio-padrão de 15,06, variando de 29,16 a 73,91. Tumores com classifica

  3. SLS launched missions concept studies for LUVOIR mission (United States)

    Stahl, H. Philip; Hopkins, Randall C.


    NASA's "Enduring Quests Daring Visions" report calls for an 8- to 16-m Large UV-Optical-IR (LUVOIR) Surveyor mission to enable ultra-high-contrast spectroscopy and coronagraphy. AURA's "From Cosmic Birth to Living Earth" report calls for a 12-m class High-Definition Space Telescope to pursue transformational scientific discoveries. The multi-center ATLAST Team is working to meet these needs. The MSFC Team is examining potential concepts that leverage the advantages of the SLS (Space Launch System). A key challenge is how to affordably get a large telescope into space. The JWST design was severely constrained by the mass and volume capacities of its launch vehicle. This problem is solved by using an SLS Block II-B rocket with its 10-m diameter x 30-m tall fairing and estimated 45 mt payload to SE-L2. Previously, two development study cycles produced a detailed concept called ATLAST-8. Using ATLAST-8 as a point of departure, this paper reports on a new ATLAST-12 concept. ATLAST-12 is a 12-m class segmented aperture LUVOIR with an 8-m class center segment. Thus, ATLAST-8 is now a de-scope option.

  4. SLS Launched Missions Concept Studies for LUVOIR Mission (United States)

    Stahl, H. Philip; Hopkins, Randall C.


    NASA's "Enduring Quests Daring Visions" report calls for an 8- to 16-meter Large UV-Optical-IR (LUVOIR) Surveyor mission to enable ultra-high-contrast spectroscopy and coronagraphy. AURA's "From Cosmic Birth to Living Earth" report calls for a 12-meter class High-Definition Space Telescope to pursue transformational scientific discoveries. The multi-center ATLAST Team is working to meet these needs. The MSFC Team is examining potential concepts that leverage the advantages of the SLS (Space Launch System). A key challenge is how to affordably get a large telescope into space. The JWST design was severely constrained by the mass and volume capacities of its launch vehicle. This problem is solved by using an SLS Block II-B rocket with its 10-m diameter x 30-m tall fairing and 45 mt payload to SE-L2. Previously, two development study cycles produced a detailed concept called ATLAST-8. Using ATLAST-8 as a point of departure, this paper reports on a new ATLAST-12 concept. ATLAST-12 is a 12-meter class segmented aperture LUVOIR with an 8-m class center segment. Thus, ATLAST-8 is now a de-scope option.

  5. Expressão citofotométrica dos marcadores tumorais CD-34 e fator VIII no câncer de cólon


    Garcia,Cacilda Joyce Ferreira da Silva; Cuenca,Ronaldo M.; Bora,Fabio Roberto; Ribas-Filho,Jurandir Marcondes; Czeczko,Nicolau Gregori; Ribas,Carmen Austrália Paredes Marcondes; Wagenführ Jr.,Jorge


    OBJETIVOS: Verificar a posssibilidade de quantificar a expressão dos marcadores tumorais CD-34 e Fator VIII no câncer de cólon; verificar se existe superioridade entre um marcador e outro para estudo da angiogênese; verificar se há correlação na análise do índice de marcagem e a densidade óptica média nos marcadores utilizados. MÉTODOS: Dezessete casos de adenocarcinoma colorretal recuperados de blocos de parafina e confirmados pela hematoxilina-eosina, foram submetidos à coloração imunoistoq...

  6. Liquid-liquid extraction and separation of VIII group elements, especially ruthenium, by synergic combinations or aromatic polyimines and micellar cationic exchangers

    International Nuclear Information System (INIS)

    Vitart, X.


    This thesis aims to characterize and to quantify the chemical equilibria involved in d-elements liquid-liquid extraction systems, especially elements belonging to the VIII group (Fe, Ni, Co, Ru, Rh, Pd, Pt). These systems are composed of synergic combination of aromatic polyimines and micellar cationic exchangers. Substitutions are first performed in aqueous acidic media by aromatic polyimines; then extractions are operated using micellic canionic exchangers. Chemical equilibria, selectivity effects, especially those due to ion-pair formations, kinetics, extractant behaviour are analysed and quantified [fr

  7. Medicinal Flowers. XXXII. Structures of oleanane-type triterpene saponins, perennisosides VIII, IX, X, XI, and XII, from the flowers of Bellis perennis. (United States)

    Morikawa, Toshio; Li, Xuezheng; Nishida, Eriko; Nakamura, Seikou; Ninomiya, Kiyofumi; Matsuda, Hisashi; Hamao, Makoto; Muraoka, Osamu; Hayakawa, Takao; Yoshikawa, Masayuki


    Five new triterpene saponins perennisosides VIII (1), IX (2), X (3), XI (4), and XII (5) were isolated from the MeOH-eluated fraction of the methanolic extract from the flowers of Bellis perennis. The MeOH-eluted fraction of the methanolic extract from the flowers of B. perennis was found to inhibit gastric emptying in olive oil-loaded mice at a dose of 200 mg/kg, per os (p.o.). The stereostructures of 1-5 were elucidated on the basis of chemical and spectroscopic evidence.

  8. Prospective Ukrainian lunar orbiter mission (United States)

    Shkuratov, Y.; Litvinenko, L.; Shulga, V.; Yatskiv, Y.; Kislyuk, V.

    Ukraine has launch vehicles that are able to deliver about 300 kg to the lunar orbit. Future Ukrainian lunar program may propose a polar orbiter. This orbiter should fill principal information gaps in our knowledge about the Moon after Clementine and Lunar Prospector missions and the future missions, like Smart-1, Lunar-A, and Selene. We consider that this can be provided by radar studies of the Moon with supporting optical polarimetric observations from lunar polar orbit. These experiments allow one to better understand global structure of the lunar surface in a wide range of scales, from microns to kilometers. We propose three instruments for the prospective lunar orbiter. They are: a synthetic aperture imaging radar (SAR), ground-penetrating radar (GPR), and imaging polarimeter (IP). The main purpose of SAR is to study with high resolution (50 m) the permanently shadowed sites in the lunar polar regions. These sites are cold traps for volatiles, and have a potential of resource utilization. Possible presence of water ice in the regolith in the sites makes them interesting for permanent manned bases on the Moon. Radar imaging and mapping of other interesting regions could be also planned. Multi-frequencies multi-polarization soun d ing of the lunar surface with GPR can provide information about internal structure of the lunar surface from meters to several hundred meters deep. GPR can be used for measuring the megaregolith layer properties, detection of cryptomaria, and studies of internal structure of the largest craters. IP will be a CCD camera with an additional suite of polarizers. Modest spatial resolution (100 m) should provide a total coverage or a large portion of the lunar surface in oblique viewing basically at large phase angles. Polarization degree at large (>90°) phase angles bears information about characteristic size of the regolith particles. Additional radiophysical experiments are considered with the use of the SAR system, e.g., bistatic radar

  9. The LUVOIR Decadal Mission Concept (United States)

    Arney, G. N.; Crooke, J.; Domagal-Goldman, S. D.; Fischer, D.; Peterson, B.; Schmidt, B. E.; Stdt, T. L. T.


    The Large UV-Optical-Infrared (LUVOIR) Surveyor is one of four mission concepts being studied by NASA in preparation for the 2020 Astrophysics Decadal Survey. LUVOIR is a general-purpose space-based observatory with a large aperture in the 8-16 m range and a total bandpass spanning from the far-UV to the near-infrared. This observatory will enable revolutionary new studies in many areas of astronomy, including planetary science within and beyond our Solar System. Because LUVOIR is being considered for the next decadal survey, it must be capable of advancing our understanding of astronomical targets, including exoplanets, far beyond what will be achieved by the next two decades of observations from other space- or ground-based facilities. This means that the mission must move past planet detection, which is happening now with Kepler and ground-based measurements and will continue with TESS (Transiting Exoplanet Survey Satellite) and WFIRST (Wide Field Infrared Survey Telescope). It must also move beyond the chemical characterization of gas giants, which has begun with observations from Spitzer, Hubble, and ground-based telescopes and will greatly advances with the upcoming JWST (James Webb Space Telescope) and WFIRST coronagraph. Therefore, one of LUVOIR's main science objectives will be to directly image rocky Earth-sized planets in the habitable zones of other stars, measure their spectra, analyze the chemistry of their atmospheres, and obtain information about their surfaces. Such observations will allow us to evaluate these worlds' habitability and potential for life. We will review the specific observational strategies needed for astrobiological assessments of exoplanetary environments, including the wavelength range and spectral resolution required for these habitability analyses and biosignature searches. Further, we will discuss how the observational requirements to make measurements of "Earthlike" worlds will allow high-quality observations of a wide

  10. Linking Knowledge and Skills to Mission Essential Competency-Based Syllabus Development for Distributed Mission Operations

    National Research Council Canada - National Science Library

    Symons, Steve; France, Michael; Bell, Jeffrey; Bennett, Jr, Winston


    ... of Mission Essential Competencies (MECs). MECs are defined as the higher order individual, team, and inter-team competencies that a fully prepared pilot, crew, or flight requires for successful mission completion under adverse conditions...

  11. Composable Mission Framework for Rapid End-to-End Mission Design and Simulation, Phase I (United States)

    National Aeronautics and Space Administration — The innovation proposed here is the Composable Mission Framework (CMF) a model-based software framework that shall enable seamless continuity of mission design and...

  12. Pathogen inactivation in fresh frozen plasma using riboflavin and ultraviolet light: Effects on plasma proteins and coagulation factor VIII

    Directory of Open Access Journals (Sweden)

    Stanojković Zoran


    Full Text Available Background/Aim. Riboflavin (vitamin B2 activated by ultraviolet (UV light, produces active oxygen which damages cell membrane and prevents replication of the carrier of diseases (viruses, bacteria, protozoa in all blood products. The aim of this study was to establish the influence of the process of photo inactivation in pathogens using riboflavin and UV rays on the concentration of coagulation factor VIII:C (FVIII:C and proteins in plasma that were treated before freezing. Methods. The examination included 20 units of plasma, separated from whole blood donated by voluntary blood donors around 6 hours from the moment of collection. The units were pooled and separated in to two groups: one consisted of 10 control units and the other of 10 experimental units. Experimental units of the plasma were treated by riboflavin (35 mL and UV rays (6.24 J/mL, 265-370 nm on Mirasol aparature (Caridian BCT Biotechnologies, USA in approximate duration of 6 minutes. Furthermore, 35 mL of saline solution was added to the control plasma. One sample for examining was taken from the control plasma (KG and two residual were taken from experimental plasma after the addition of riboflavin either before (EG1 or post illumination (EG2. Results. Comparing the mean values of FVIII:C (% we noticed statistically significantly higher level in the EG1 group than in the EG2 group (65.00 ± 4.52 vs 63.20 ± 4.73; t = 4.323, p = 0.002, while between the KG and experimental groups (EG1 and EG2 there was no statistically significant difference in the concentration of FVIII:C. There was a statistically significant decrease of albumin concentration (g/L in the EG2 group comparing to the KG (33.35 ± 0.94 vs 31.94 ± 0.84; t = 3.534, p = 0.002, but there was no mentioned difference in albumin concentration between the KG and the EG1, so as between the EG1 and the EG2. Conclusion. Plasma inactivated by riboflavin and UV rays (Mirasol PRT sistem, Caridian BCT, USA keeps all the

  13. Milk fat globule-epidermal growth factor-factor VIII attenuates sepsis-induced acute kidney injury. (United States)

    Cen, Cindy; Aziz, Monowar; Yang, Weng-Lang; Zhou, Mian; Nicastro, Jeffrey M; Coppa, Gene F; Wang, Ping


    Acute kidney injury (AKI) is most commonly caused by sepsis in critically ill patients, and it is associated with high morbidity and mortality. The pathophysiology of sepsis-induced AKI is generally accepted to include direct inflammatory injury, endothelial cell dysfunction, and apoptosis. Milk fat globule-epidermal growth factor-factor VIII (MFG-E8) is a secretory glycoprotein with a known role in the enhancement of apoptotic cell clearance and regulation of inflammation. We hypothesize that administration of recombinant mouse MFG-E8 (rmMFG-E8) can protect mice from kidney injuries caused by sepsis. Sepsis was induced in 8-wk-old male C57BL/6 mice by cecal ligation and puncture (CLP). rmMFG-E8 or phosphate-buffered saline (vehicle) was injected intravenously at a dosage of 20 μg/kg body weight at time of CLP (n = 5-8 mice per group). After 20 h, serum and renal tissue were harvested for various analyses. The renal injury markers blood urea nitrogen (BUN) and creatinine were determined by enzymatic and chemical reactions, respectively. The gene expression analysis was carried out by real-time quantitative polymerase chain reaction. At 20 h after CLP, serum levels of BUN and creatinine were both significantly increased in the vehicle group compared with the sham group, whereas the mice treated with rmMFG-E8 had a significant reduction in BUN and creatinine levels by 28% and 24.1%, respectively (BUN: 197.7 ± 23.6 versus 142.3 ± 20.7 mg/dL; creatinine: 0.83 ± 0.12 versus 0.63 ± 0.06 mg/dL; P sepsis through inhibiting the production of proinflammatory cytokines and chemokine, as well as through the activation of endothelial cells. Thus, MFG-E8 may have a therapeutic potential for treating AKI induced by sepsis. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. The Swift GRB MIDEX Mission

    International Nuclear Information System (INIS)

    Gehrels, N.


    Swift is a first-of-its-kind multiwavelength transient observatory for gamma-ray burst astronomy. It has the optimum capabilities for the next breakthroughs in determining the origin of gamma-ray bursts and their afterglows, as well as using bursts to probe the early Universe. Swift will also perform the first sensitive hard X-ray survey of the sky. The mission is being developed by an international collaboration and consists of three instruments, the Burst Alert Telescope (BAT), the X-ray Telescope (XRT), and the Ultraviolet and Optical Telescope (UVOT). The BAT, a wide-field gamma-ray detector, will detect 3-7 gamma-ray bursts per week with a sensitivity 5 times that of BATSE. The sensitive narrow-field XRT and UVOT will be autonomously slewed to the burst location in 20 to 70 seconds to determine 0.3-5.0 arcsec positions and perform optical, UV, and X-ray spectrophotometry. Strong education/public outreach and follow-up programs will help to engage the public and astronomical community. The Swift launch is planned for September 2003

  15. The LUVOIR Large Mission Concept (United States)

    O'Meara, John; LUVOIR Science and Technology Definition Team


    LUVOIR is one of four large mission concepts for which the NASA Astrophysics Division has commissioned studies by Science and Technology Definition Teams (STDTs) drawn from the astronomical community. We are currently developing two architectures: Architecture A with a 15.1 meter segmented primary mirror, and Architecture B with a 9.2 meter segmented primary mirror. Our focus in this presentation is the Architecture A LUVOIR. LUVOIR will operate at the Sun-Earth L2 point. It will be designed to support a broad range of astrophysics and exoplanet studies. The initial instruments developed for LUVOIR Architecture A include 1) a high-performance optical/NIR coronagraph with imaging and spectroscopic capability, 2) a UV imager and spectrograph with high spectral resolution and multi-object capability, 3) a high-definition wide-field optical/NIR camera, and 4) a high resolution UV/optical spectropolarimeter. LUVOIR will be designed for extreme stability to support unprecedented spatial resolution and coronagraphy. It is intended to be a long-lifetime facility that is both serviceable, upgradable, and primarily driven by guest observer science programs. In this presentation, we will describe the observatory, its instruments, and survey the transformative science LUVOIR can accomplish.

  16. Community College Mission: A '60s Mission Looking at a Y2K World. (United States)

    Levin, Bernard H.

    Although the world has changed considerably in the past three decades, community colleges and their guiding missions have largely not adapted to changing conditions. College mission statements tend to be unfocused documents that provide overly broad goals. In the business world, the mission statements of effective companies are brief, crisp, and…

  17. Integrated payload and mission planning, phase 3. Volume 3: Ground real-time mission operations (United States)

    White, W. J.


    The payloads tentatively planned to fly on the first two Spacelab missions were analyzed to examine the cost relationships of providing mission operations support from onboard vs the ground-based Payload Operations Control Center (POCC). The quantitative results indicate that use of a POCC, with data processing capability, to support real-time mission operations is the most cost effective case.

  18. Evolution of Orion Mission Design for Exploration Mission 1 and 2 (United States)

    Gutkowski, Jeffrey P.; Dawn, Timothy F.; Jedrey, Richard M.


    The evolving mission design and concepts of NASA’s next steps have shaped Orion into the spacecraft that it is today. Since the initial inception of Orion, through the Constellation Program, and now in the Exploration Mission frame-work with the Space Launch System (SLS), each mission design concept and pro-gram goal have left Orion with a set of capabilities that can be utilized in many different mission types. Exploration Missions 1 and 2 (EM-1 and EM-2) have now been at the forefront of the mission design focus for the last several years. During that time, different Design Reference Missions (DRMs) were built, analyzed, and modified to solve or mitigate enterprise level design trades to ensure a viable mission from launch to landing. The resulting DRMs for EM-1 and EM-2 were then expanded into multi-year trajectory scans to characterize vehicle performance as affected by variations in Earth-Moon geometry. This provides Orion’s subsystems with stressing reference trajectories to help design their system. Now that Orion has progressed through the Preliminary and Critical Design Reviews (PDR and CDR), there is a general shift in the focus of mission design from aiding the vehicle design to providing mission specific products needed for pre-flight and real time operations. Some of the mission specific products needed include, large quantities of nominal trajectories for multiple monthly launch periods and abort options at any point in the mission for each valid trajectory in the launch window.

  19. Tank waste remediation system mission analysis report

    International Nuclear Information System (INIS)

    Acree, C.D.


    The Tank Waste Remediation System Mission Analysis Report identifies the initial states of the system and the desired final states of the system. The Mission Analysis Report identifies target measures of success appropriate to program-level accomplishments. It also identifies program-level requirements and major system boundaries and interfaces

  20. Basic radio interferometry for future lunar missions

    NARCIS (Netherlands)

    Aminaei, Amin; Klein Wolt, Marc; Chen, Linjie; Bronzwaer, Thomas; Pourshaghaghi, Hamid Reza; Bentum, Marinus Jan; Falcke, Heino


    In light of presently considered lunar missions, we investigate the feasibility of the basic radio interferometry (RIF) for lunar missions. We discuss the deployment of two-element radio interferometer on the Moon surface. With the first antenna element is envisaged to be placed on the lunar lander,

  1. The Ballerina experiment on the Romer mission

    DEFF Research Database (Denmark)

    Brandt, Søren Kristian


    The Romer mission has recently been approved as the next mission within the Danish Small Satellite Program. The scientific payload will consist of two separate experiments, the MONS and the Ballerina payloads. The primary objective of Ballerina is to provide accurate, real-time positions relayed...

  2. Core Science Systems--Mission overview (United States)

    Gallagher, Kevin T.


    The Core Science Systems Mission Area delivers nationally focused Earth systems and information science that provides fundamental research and data that underpins all Mission Areas of the USGS, the USGS Science Strategy, and Presidential, Secretarial, and societal priorities. —Kevin T. Gallagher, Associate Director, Core Science Systems


    African Journals Online (AJOL)

    Nevertheless, if Gentile Christians speak with Jews they have to witness that Jesus is the Christ. They have to do so (at the very least) in order to explain to the Jews that they, as Gentiles, are also children of the God of Israel. Many books have been published on the method of mission with the focus on mission among the ...

  4. Student Trade Missions: An Experiential Learning Opportunity (United States)

    Audet, Josée; Marcotte, Geneviève


    In response to the criticisms addressed to business schools, teaching formulas that foster experiential learning are increasingly being put forward. The Missions Commerciales de l'Université Laval (MCUL--Université Laval Trade Missions) is a training program designed to foster experiential learning. This program extends over an entire academic…

  5. Growing fresh food on future space missions

    NARCIS (Netherlands)

    Meinen, Esther; Dueck, Tom; Kempkes, Frank; Stanghellini, Cecilia


    This paper deals with vegetable cultivation that could be faced in a space mission. This paper focusses on optimization, light, temperature and the harvesting process, while other factors concerning cultivation in space missions, i.e. gravity, radiation, were not addressed. It describes the work

  6. Emblem for the first manned Skylab mission (United States)


    This is the emblem for the first manned Skylab mission. It wil be a mission of up to 28 days. The patch, designed by artist Kelly Freas, shows the Skylab silhouetted against the earth's globe, which in turn is eclipsing the Sun - showing the brilliant signet-ring pattern of the instant before total eclipse.

  7. Trajectory Design Considerations for Exploration Mission 1 (United States)

    Dawn, Timothy F.; Gutkowski, Jeffrey P.; Batcha, Amelia L.; Williams, Jacob; Pedrotty, Samuel M.


    Exploration Mission 1 (EM-1) will be the first mission to send an uncrewed Orion Multi-Purpose Crew Vehicle (MPCV) to cislunar space in the fall of 2019. EM-1 was originally conceived as a lunar free-return mission, but was later changed to a Distant Retrograde Orbit (DRO) mission as a precursor to the Asteroid Redirect Mission. To understand the required mission performance (i.e., propellant requirement), a series of trajectory optimization runs was conducted using JSC's Copernicus spacecraft trajectory optimization tool. In order for the runs to be done in a timely manner, it was necessary to employ a parallelization approach on a computing cluster using a new trajectory scan tool written in Python. Details of the scan tool are provided and how it is used to perform the scans and post-process the results. Initially, a scan of daily due east launched EM-1 DRO missions in 2018 was made. Valid mission opportunities are ones that do not exceed the useable propellant available to perform the required burns. The initial scan data showed the propellant and delta-V performance patterns for each launch period. As questions were raised from different subsystems (e.g., power, thermal, communications, flight operations, etc.), the mission parameters or data that were of interest to them were added to the scan output data file. The additional data includes: (1) local launch and landing times in relation to sunrise and sunset, (2) length of eclipse periods during the in-space portion of the mission, (3) Earth line of sight from cislunar space, (4) Deep Space Network field of view looking towards cislunar space, and (5) variation of the downrange distance from Earth entry interface to splashdown. Mission design trades can also be performed based on the information that the additional data shows. For example, if the landing is in darkness, but the recovery operations team desires a landing in daylight, then an analysis is performed to determine how to change the mission design

  8. Miscellaneous botanical Notes VIII

    NARCIS (Netherlands)

    Steenis, van C.G.G.J.


    The only record of Thesium in Malaysia was hitherto the Southern Chinese Thesium psilotoides Hance from medium altitudes of the Benguet and Bontoe Mountain Provinces in North Luzon, according to Merrill (Enum. Philip. Fl. Pl. 2, 1923, 115), occurring between 1200 and 1500 m. The same species has

  9. The Economics of NASA Mission Cost Reserves (United States)

    Whitley, Sally; Shinn, Stephen


    Increases in NASA mission costs have led to analysis of the causes and magnitude of historical mission overruns as well as mitigation and prevention attempts. This paper hypothesizes that one cause is that the availability of reserves may reduce incentives to control costs. We draw a comparison to the insurance concept of moral hazard, and we use actuarial techniques to better understand the increase in mission costs due to the availability of reserves. NASA's CADRe database provided the data against which we tested our hypothesis and discovered that there is correlation between the amount of available reserves and project overruns, particularly for mission hardware cost increases. We address the question of how to prevent reserves from increasing mission spending without increasing cost risk to projects.

  10. Human missions to Mars: issues and challenges (United States)

    Race, M.; Kminek, G.

    Recent announcements of the planned future human exploration of Mars by both European and US space agencies have raised a host of questions and challenges that must be addressed in advance of long-duration human missions. While detailed mission planning is a long way off, numerous issues can already be identified in the broad context of planetary protection. In this session, a panel of experts will provide brief overviews of the types of challenges ahead, such as the protection of the martian environment; the integration of human and robotic mission elements and operations; precursor scientific information necessary to plan human missions; development and use of nuclear and other technologies for the protection and support of astronauts during the mission; protection of Earth upon return; and societal and ethical questions about human exploration. The session has been designed to encourage and incorporate audience participation in the discussion about the issues and challenges ahead.

  11. Approach to Spacelab Payload mission management (United States)

    Craft, H. G.; Lester, R. C.


    The nucleus of the approach to Spacelab Payload mission management is the establishment of a single point of authority for the entire payload on a given mission. This single point mission manager will serve as a 'broker' between the individual experiments and the STS, negotiating agreements by two-part interaction. The payload mission manager, along with a small support team, will represent the users in negotiating use of STS accommodations. He will provide the support needed by each individual experimenter to meet the scientific, technological, and applications objectives of the mission with minimum cost and maximum efficiency. The investigator will assume complete responsibility for his experiment hardware definition and development and will take an active role in the integration and operation of his experiment.

  12. First Solid Evidence for a Rocky Exoplanet - Mass and density of smallest exoplanet finally measured (United States)


    measurement for an exoplanet. Both were needed to discover a rocky planet with the same density as the Earth," says co-author Artie Hatzes. CoRoT-7b earns another distinction as the closest known exoplanet to its host star, which also makes it the fastest - it orbits its star at a speed of more than 750 000 kilometres per hour, more than seven times faster than the Earth's motion around the Sun. "In fact, CoRoT-7b is so close that the place may well look like Dante's Inferno, with a probable temperature on its 'day-face' above 2000 degrees and minus 200 degrees on its night face. Theoretical models suggest that the planet may have lava or boiling oceans on its surface. With such extreme conditions this planet is definitively not a place for life to develop," says Queloz. As a further testament to HARPS' sublime precision, the astronomers found from their dataset that CoRoT-7 hosts another exoplanet slightly further away than CoRoT-7b. Designated CoRoT-7c, it circles its host star in 3 days and 17 hours and has a mass about eight times that of Earth, so it too is classified as a super-Earth. Unlike CoRoT-7b, this sister world does not pass in front of its star as seen from Earth, so astronomers cannot measure its radius and thus its density. Given these findings, CoRoT-7 stands as the first star known to have a planetary system made of two short period super-Earths with one that transits its host. Notes [1] The CoRoT mission is a cooperation between France and its international partners: ESA, Austria, Belgium, Brazil, Germany and Spain. [2] We see exactly the same effect in our Solar System when Mercury or Venus transits the solar disc, as Venus did on 8 June 2004. In the past centuries such events were used to estimate the Sun-Earth distance, with extremely useful implications for astrophysics and celestial mechanics. [3] Gliese 581e, also discovered with HARPS, has a minimum mass about twice the Earth's mass (see ESO 15/09), but the exact geometry of the orbit is undefined

  13. Parametric cost estimation for space science missions (United States)

    Lillie, Charles F.; Thompson, Bruce E.


    Cost estimation for space science missions is critically important in budgeting for successful missions. The process requires consideration of a number of parameters, where many of the values are only known to a limited accuracy. The results of cost estimation are not perfect, but must be calculated and compared with the estimates that the government uses for budgeting purposes. Uncertainties in the input parameters result from evolving requirements for missions that are typically the "first of a kind" with "state-of-the-art" instruments and new spacecraft and payload technologies that make it difficult to base estimates on the cost histories of previous missions. Even the cost of heritage avionics is uncertain due to parts obsolescence and the resulting redesign work. Through experience and use of industry best practices developed in participation with the Aerospace Industries Association (AIA), Northrop Grumman has developed a parametric modeling approach that can provide a reasonably accurate cost range and most probable cost for future space missions. During the initial mission phases, the approach uses mass- and powerbased cost estimating relationships (CER)'s developed with historical data from previous missions. In later mission phases, when the mission requirements are better defined, these estimates are updated with vendor's bids and "bottoms- up", "grass-roots" material and labor cost estimates based on detailed schedules and assigned tasks. In this paper we describe how we develop our CER's for parametric cost estimation and how they can be applied to estimate the costs for future space science missions like those presented to the Astronomy & Astrophysics Decadal Survey Study Committees.


    Directory of Open Access Journals (Sweden)

    Eni Fitriani


    Full Text Available The purpose of this study was to investigate the effect of variations in the methods and models of teaching to student learning outcomes VIII SMPN2 MARGA TIGA.This research is experimental research which ofdesign completely randomized or completely randomized experimental design.The population in thisresearch is all of student VIII class in SMPN 2 MARGA TIGA2013/2014. The sample in this research is VIIIth class which totaling 34 students.In this research, conducted with three treatments of learning in a classroom.Data collection techniques in this research use the technique of the test, which tests the end (posttest were then analyzed with the test results hipotesis. From posttest analysis results of hypothesis testing using one-way ANOVA test (Completely Randomized Design at the 5% significance level value obtained results Fobs = 1.5244 and Ftab = 3.10 this shows that H0 is accepted and means variety of methods and learning models provide a similar impact on student learning outcomes.It can be concluded that all three treatments had similar quality if tailored to the needs of all three materials. 

  15. Analysis of the 4d7 (4f + 6p) and 4p54d9 configurations of Sn VII, Sb VIII and Te IX

    International Nuclear Information System (INIS)

    Azarov, V.I.; Joshi, Y.N.; Churilov, S.S.; Ryabtsev, A.N.


    The spectra of tin, antimony and tellerium were photographed in the 120-200 A region on 10.7 m and 3 m grazing incidence spectrographs using a triggered spark source. The 4d 8 -4d 7 (4f + 6p) + 4p 5 4d 9 transitions of Sn VII, Sb VIII and Te IX were investigated. In the Sn VII spectrum 109 new lines were classified in the 152-192 A region and 34 new levels were established, in the Sb VIII spectrum 78 new lines were classified in the 138-158 A region and 21 new levels were established, and in the Te IX 76 new lines were classified in the 121-139 A region and 21 new levels were established. Strong configuration interaction among the 4d 7 (np + mf), and 4p 5 4d 9 (n = 5, 6; m = 4, 5) configurations was observed. Least-squares-fitting (LSF) parametric calculations involving configuration interaction were carried out to interpret the observed spectra. (orig.)


    International Nuclear Information System (INIS)

    Henley, David B.; Shelton, Robin L.


    We present measurements of the soft X-ray background (SXRB) O VII and O VIII intensity between l = 120 deg. and l = 240 deg., the first results of a survey of the SXRB using archival XMM-Newton observations. We do not restrict ourselves to blank-sky observations, but instead use as many observations as possible, removing bright or extended sources by hand if necessary. In an attempt to minimize contamination from near-Earth solar wind charge exchange (SWCX) emission, we remove times of high solar wind proton flux from the data. Without this filtering we are able to extract measurements from 586 XMM-Newton observations. With this filtering, ∼1/2 of the observations are rendered unusable, and we are able to extract measurements from 303 observations. The oxygen intensities are typically ∼0.5-10 photons cm -2 s -1 sr -1 (line units, L.U.) for O VII and ∼0-5 L.U. for O VIII. The proton flux filtering does not systematically reduce the oxygen intensities measured from a given observation. However, the filtering does preferentially remove the observations with higher oxygen intensities. Our data set includes 69 directions with multiple observations, whose oxygen intensity variations can be used to constrain SWCX models. One observation exhibits an O VII enhancement of ∼25 L.U. over two other observations of the same direction, although most SWCX enhancements are ∼ 6 K, in good agreement with previous studies.

  17. Endothelial cell markers in vascular neoplasms: an immunohistochemical study comparing factor VIII-related antigen, blood group specific antigens, 6-keto-PGF1 alpha, and Ulex europaeus 1 lectin. (United States)

    Little, D; Said, J W; Siegel, R J; Fealy, M; Fishbein, M C


    Markers for endothelial cells including Ulex europaeus 1 lectin, blood group A, B, and H, and the prostaglandin metabolite 6-keto-PGF1 alpha were evaluated in paraffin secretions from formalin-fixed benign and malignant vascular neoplasms using a variety of immunohistochemical techniques, and results compared with staining for factor VIII-related antigen. Staining for Ulex appeared more sensitive than factor VIII-related antigen in identifying poorly differentiated neoplasms including haemangiosarcomas and spindle cell proliferations in Kaposi's sarcoma. Staining for blood group related antigens correlated with blood group in all cases. Ulex europaeus 1 lectin was the only marker for endothelial cells in lymphangiomas.

  18. Astronaut Clothing for Exploration Missions (United States)

    Poritz, Darwin H.; Orndoff, Evelyne; Kaspranskiy, Rustem R.; Schesinger, Thilini; Byrne, Vicky


    Astronaut clothes for exploration missions beyond low Earth orbit need to satisfy several challenges not met by the currently-used mostly-cotton clothing. A laundering system is not expected to be available, and thus soiled garments must be trashed. Jettisoning waste does not seem feasible at this time. The cabin oxygen concentration is expected to be higher than standard, and thus fabrics must better resist ignition and burning. Fabrics need to be identified that reduce logistical mass, that can be worn longer before disposal, that are at least as comfortable as cotton, and that resist ignition or that char immediately after ignition. Human factors and psychology indicate that crew well-being and morale require a variety of colors and styles to accommodate personal identity and preferences. Over the past four years, the Logistics Reduction Project under NASA's Advanced Exploration Systems Program has sponsored the Advanced Clothing System Task to conduct several ground studies and one ISS study. These studies have evaluated length of wear and personal preferences of commercially-available exercise- and routine-wear garments made from several fabrics (cotton, polyester, Merino wool, and modacrylic), woven and knitted. Note that Merino wool and modacrylic char like cotton in ambient air, while polyester unacceptably melts. This paper focuses on the two components of an International Space Station study, onboard and on the ground, with astronauts and cosmonauts. Fabrics were randomized to participants. Length of wear was assessed by statistical survival analysis, and preference by exact binomial confidence limits. Merino wool and modacrylic t-shirts were worn longer on average than polyester t-shirts. Interestingly, self-assessed preferences were inconsistent with length-of-wear behavior, as polyester was preferred to Merino wool and modacrylic.

  19. MMPM - Mars MetNet Precursor Mission (United States)

    Harri, A.-M.; Schmidt, W.; Pichkhadze, K.; Linkin, V.; Vazquez, L.; Uspensky, M.; Polkko, J.; Genzer, M.; Lipatov, A.; Guerrero, H.; Alexashkin, S.; Haukka, H.; Savijarvi, H.; Kauhanen, J.


    We are developing a new kind of planetary exploration mission for Mars - MetNet in situ observation network based on a new semi-hard landing vehicle called the Met-Net Lander (MNL). The eventual scope of the MetNet Mission is to deploy some 20 MNLs on the Martian surface using inflatable descent system structures, which will be supported by observations from the orbit around Mars. Currently we are working on the MetNet Mars Precursor Mission (MMPM) to deploy one MetNet Lander to Mars in the 2009/2011 launch window as a technology and science demonstration mission. The MNL will have a versatile science payload focused on the atmospheric science of Mars. Detailed characterization of the Martian atmospheric circulation patterns, boundary layer phenomena, and climatology cycles, require simultaneous in-situ measurements by a network of observation posts on the Martian surface. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. The MetNet mission concept and key probe technologies have been developed and the critical subsystems have been qualified to meet the Martian environmental and functional conditions. Prototyping of the payload instrumentation with final dimensions was carried out in 2003-2006.This huge development effort has been fulfilled in collaboration between the Finnish Meteorological Institute (FMI), the Russian Lavoschkin Association (LA) and the Russian Space Research Institute (IKI) since August 2001. Currently the INTA (Instituto Nacional de Técnica Aeroespacial) from Spain is also participating in the MetNet payload development. To understand the behavior and dynamics of the Martian atmosphere, a wealth of simultaneous in situ observations are needed on varying types of Martian orography, terrain and altitude spanning all latitudes and longitudes. This will be performed by the Mars MetNet Mission. In addition to the science aspects the

  20. Stakeholder Orientation in Cruise Lines’ Mission Statements

    Directory of Open Access Journals (Sweden)

    Lara Penco


    Full Text Available Consistent with the extant management literature, mission statements are crucial for the sustainability and growth of any firms and have been considered to be a tool for the strategic management process. Despite the considerable attention awarded to this theme, the role of the mission statement in the strategic management of tourism firms has not been sufficiently highlighted. The present paper tries to bridge this literature gap and aims to (i analyze the content of mission statements; and (ii investigate the stakeholder orientation of cruise line mission statements. We apply a content analysis method to analyze the mission statements of 44 cruise lines, employing three different perspectives: (1 the inclusion of stakeholder groups; (2 mentions of specific “mission” components; (3 reference to four goals usually assigned to mission statements. The analysis was performed using the software package QDA-Miner. The results suggest that it is possible to identify four clusters of firms that present similar content in their mission statements, and that cruise companies tend to reserve a major attention to customers. This contribution presents some valuable research implications mainly useful for researchers and academics, but also maybe of benefit to professionals and investors.

  1. The deep space 1 extended mission (United States)

    Rayman, Marc D.; Varghese, Philip


    The primary mission of Deep Space 1 (DS1), the first flight of the New Millennium program, completed successfully in September 1999, having exceeded its objectives of testing new, high-risk technologies important for future space and Earth science missions. DS1 is now in its extended mission, with plans to take advantage of the advanced technologies, including solar electric propulsion, to conduct an encounter with comet 19P/Borrelly in September 2001. During the extended mission, the spacecraft's commercial star tracker failed; this critical loss prevented the spacecraft from achieving three-axis attitude control or knowledge. A two-phase approach to recovering the mission was undertaken. The first involved devising a new method of pointing the high-gain antenna to Earth using the radio signal received at the Deep Space Network as an indicator of spacecraft attitude. The second was the development of new flight software that allowed the spacecraft to return to three-axis operation without substantial ground assistance. The principal new feature of this software is the use of the science camera as an attitude sensor. The differences between the science camera and the star tracker have important implications not only for the design of the new software but also for the methods of operating the spacecraft and conducting the mission. The ambitious rescue was fully successful, and the extended mission is back on track.


    Directory of Open Access Journals (Sweden)



    Full Text Available The mission is generic expression of reason for the existence of an organization. Organizational mission ensure continuity of existence beyond the objectives and targets of activities. It is the expression of an organization's responsibilities towards the environment in which it belongs. As the organization grows and its activities or environmental conditions change, managers adapt their strategies, but stated mission will remain valid for a period of time or unchanged throughout the life of the organization. All managerial elements of the organization are aligned with stated mission, starting from the organization structure, management behavior or specific business processes. The focus of the mission of an higher education institution on a need or several integrated needs, on customers who manifest this need and on how they can be met, that really means defining of its strategic domanin, as a sphere of influence of the organization in their environment. In this sphere of influence, three components integrate on three levels of the mission: to establish needs; identify the customer type to which an organization adress and key competencies that differentiate it from the rest competitors. To that context identifies four specific forms of academic institutions starting from their mission and strategic area: autocratic academic institutions, meritocrate academic institutions, democratic academic institutions, bureaucrats academic institutions.

  3. Understanding NEOs: The Role of Characterization Missions (United States)

    Morrison, David


    NEOs are important from multiple perspectives, including science, hazard mitigation, space resources, and as targets for human missions. Much can be learned from ground-based studies, especially with radar, but the unique value of in situ investigation has been shown by missions such as NEAR-Shoemaker and Hayabusa to asteroids Eros and Itokawa, and Deep Impact and Stardust to comets. The next mission targets are likely to be NEAs in the subkilometer size range. Because these smaller objects are much more numerous, they are the objects we most need to understand from a defense perspective, and they are also the most likely targets for early human missions. However, there are unique challenges in sending spacecraft to investigate sub-km asteroids. Reconnaissance flybys are of little use, orbiting requires active control, and landing on such a low-gravity surface is perhaps better described as docking. Yet we need to operate close to the target, and probably to land, to obtain crucial information about interior structure. This paper deals primarily with small landers like the Near Earth Asteroid Trailblazer Mission (NEAT) studied at Ames Research Center. The NEAT objectives are to provide global reconnaissance (shape, mass, density, dynamical state), in situ surface characterization, and long-term precision tracking. Alternative approaches use deep-penetrating radar and electromagnetic sounding to probe interior structure. A third class of missions is ballistic impactors such as the ESA Don Quijote, which test one of the technologies for deflecting small asteroids. If the targets are selected for their accessibility, such missions could be implemented with low-cost launchers such as Pegasus, Falcon, or Minotaur. Such missions will have high science return. But from the perspective of defense, we have not yet developed a consensus strategy for the role of such characterization missions.

  4. Nuclear propulsion tradeoffs for manned Mars missions

    International Nuclear Information System (INIS)

    Walton, L.A.; Malloy, J.D.


    A conjunction class split/sprint manned Mars exploration mission was studied to evaluate tradeoffs in performance characteristics of nuclear thermal rockets. A Particle Bed Reactor-based nuclear thermal rocket was found to offer a 38% to 52% total mass savings compared with a NERVA-based nuclear thermal rocket for this mission. This advantage is primarily due to the higher thrust-to-weight ratio of the Particle Bed Reactor nuclear rocket. The mission is enabled by nuclear thermal rockets. It cannot be performed practically using chemical propulsion

  5. Training Concept for Long Duration Space Mission (United States)

    O'Keefe, William


    There has been papers about maintenance and psychological training for Long Duration Space Mission (LDSM). There are papers on the technology needed for LDSMs. Few are looking at how groundbased pre-mission training and on-board in-transit training must be melded into one training concept that leverages this technology. Even more importantly, fewer are looking at how we can certify crews pre-mission. This certification must ensure, before the crew launches, that they can handle any problem using on-board assets without a large ground support team.

  6. Mars MetNet Mission Payload Overview (United States)

    Harri, A.-M.; Haukka, H.; Alexashkin, S.; Guerrero, H.; Schmidt, W.; Genzer, M.; Vazquez, L.


    A new kind of planetary exploration mission for Mars is being developed in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission [1] is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide crucial scientific data about the Martian atmospheric phenomena.

  7. Elevated Factor VIII and von Willebrand Factor Levels Predict Unfavorable Outcome in Stroke Patients Treated with Intravenous Thrombolysis

    Directory of Open Access Journals (Sweden)

    Noémi Klára Tóth


    Full Text Available IntroductionPlasma factor VIII (FVIII and von Willebrand factor (VWF levels have been associated with the rate and severity of arterial thrombus formation and have been linked to outcomes following thrombolytic therapy in acute myocardial infarction patients. Here, we aimed to investigate FVIII and VWF levels during the course of thrombolysis in acute ischemic stroke (AIS patients and to find out whether they predict long-term outcomes.Materials and methodsStudy population included 131 consecutive AIS patients (median age: 69 years, 60.3% men who underwent i.v. thrombolysis with recombinant tissue plasminogen activator (rt-PA. Blood samples were taken on admission, 1 and 24 h after rt-PA administration to measure FVIII activity and VWF antigen levels. Neurological deficit of patients was determined according to the National Institutes of Health Stroke Scale (NIHSS. ASPECT scores were assessed using computer tomography images taken before and 24 h after thrombolysis. Intracranial hemorrhage was classified according to the European Cooperative Acute Stroke Study (ECASS II criteria. Long-term functional outcome was determined at 90 days after the event by the modified Rankin scale (mRS.ResultsVWF levels on admission were significantly elevated in case of more severe AIS [median and IQR values: NIHSS <6:189.6% (151.9–233.2%; NIHSS 6–16: 199.6% (176.4–250.8%; NIHSS >16: 247.8% (199.9–353.8%, p = 0.013]; similar, but non-significant trend was observed for FVIII levels. FVIII and VWF levels correlated well on admission (r = 0.748, p < 0.001 but no significant correlation was found immediately after thrombolysis (r = 0.093, p = 0.299, most probably due to plasmin-mediated FVIII degradation. VWF levels at all investigated occasions and FVIII activity before and 24 h after thrombolysis were associated with worse 24 h post-lysis ASPECT scores. In a binary backward logistic regression analysis including age, gender

  8. NASA's Planetary Science Missions and Participations (United States)

    Daou, Doris; Green, James L.


    NASA's Planetary Science Division (PSD) and space agencies around the world are collaborating on an extensive array of missions exploring our solar system. Planetary science missions are conducted by some of the most sophisticated robots ever built. International collaboration is an essential part of what we do. NASA has always encouraged international participation on our missions both strategic (ie: Mars 2020) and competitive (ie: Discovery and New Frontiers) and other Space Agencies have reciprocated and invited NASA investigators to participate in their missions. NASA PSD has partnerships with virtually every major space agency. For example, NASA has had a long and very fruitful collaboration with ESA. ESA has been involved in the Cassini mission and, currently, NASA funded scientists are involved in the Rosetta mission (3 full instruments, part of another), BepiColombo mission (1 instrument in the Italian Space Agency's instrument suite), and the Jupiter Icy Moon Explorer mission (1 instrument and parts of two others). In concert with ESA's Mars missions NASA has an instrument on the Mars Express mission, the orbit-ground communications package on the Trace Gas Orbiter (launched in March 2016) and part of the DLR/Mars Organic Molecule Analyzer instruments going onboard the ExoMars Rover (to be launched in 2018). NASA's Planetary Science Division has continuously provided its U.S. planetary science community with opportunities to include international participation on NASA missions too. For example, NASA's Discovery and New Frontiers Programs provide U.S. scientists the opportunity to assemble international teams and design exciting, focused planetary science investigations that would deepen the knowledge of our Solar System. The PSD put out an international call for instruments on the Mars 2020 mission. This procurement led to the selection of Spain and Norway scientist leading two instruments and French scientists providing a significant portion of another

  9. Planet Detection: The Kepler Mission (United States)

    Jenkins, Jon M.; Smith, Jeffrey C.; Tenenbaum, Peter; Twicken, Joseph D.; Van Cleve, Jeffrey


    The search for exoplanets is one of the hottest topics in astronomy and astrophysics in the twenty-first century, capturing the public's attention as well as that of the astronomical community. This nascent field was conceived in 1989 with the discovery of a candidate planetary companion to HD114762 [35] and was born in 1995 with the discovery of the first extrasolar planet 51 Peg-b [37] orbiting a main sequence star. As of March, 2011, over 500 exoplanets have been discovered* and 106 are known to transit or cross their host star, as viewed from Earth. Of these transiting planets, 15 have been announced by the Kepler Mission, which was launched into an Earth-trailing, heliocentric orbit in March, 2009 [1,4,6,15,18,20,22,31,32,34,36,43]. In addition, over 1200 candidate transiting planets have already been detected by Kepler [5], and vigorous follow-up observations are being conducted to vet these candidates. As the false-positive rate for Kepler is expected to be quite low [39], Kepler has effectively tripled the number of known exoplanets. Moreover, Kepler will provide an unprecedented data set in terms of photometric precision, duration, contiguity, and number of stars. Kepler's primary science objective is to determine the frequency of Earth-size planets transiting their Sun-like host stars in the habitable zone, that range of orbital distances for which liquid water would pool on the surface of a terrestrial planet such as Earth, Mars, or Venus. This daunting task demands an instrument capable of measuring the light output from each of over 100,000 stars simultaneously with an unprecedented photometric precision of 20 parts per million (ppm) at 6.5-h intervals. The large number of stars is required because the probability of the geometrical alignment of planetary orbits that permit observation of transits is the ratio of the size of the star to the size of the planetary orbit. For Earth-like planets in 1-astronomical unit (AU) orbits† about sun-like stars

  10. Designing Mission Operations for the Gravity Recovery and Interior Laboratory Mission (United States)

    Havens, Glen G.; Beerer, Joseph G.


    NASA's Gravity Recovery and Interior Laboratory (GRAIL) mission, to understand the internal structure and thermal evolution of the Moon, offered unique challenges to mission operations. From launch through end of mission, the twin GRAIL orbiters had to be operated in parallel. The journey to the Moon and into the low science orbit involved numerous maneuvers, planned on tight timelines, to ultimately place the orbiters into the required formation-flying configuration necessary. The baseline GRAIL mission is short, only 9 months in duration, but progressed quickly through seven very unique mission phases. Compressed into this short mission timeline, operations activities and maneuvers for both orbiters had to be planned and coordinated carefully. To prepare for these challenges, development of the GRAIL Mission Operations System began in 2008. Based on high heritage multi-mission operations developed by NASA's Jet Propulsion Laboratory and Lockheed Martin, the GRAIL mission operations system was adapted to meet the unique challenges posed by the GRAIL mission design. This paper describes GRAIL's system engineering development process for defining GRAIL's operations scenarios and generating requirements, tracing the evolution from operations concept through final design, implementation, and validation.

  11. A mission to Mercury and a mission to the moons of Mars (United States)


    Two Advanced Design Projects were completed this academic year at Penn State - a mission to the planet Mercury and a mission to the moons of Mars (Phobos and Deimos). At the beginning of the fall semester the students were organized into six groups and given their choice of missions. Once a mission was chosen, the students developed conceptual designs. These designs were then evaluated at the end of the fall semester and combined into two separate mission scenarios. To facilitate the work required for each mission, the class was reorganized in the spring semester by combining groups to form two mission teams. An integration team consisting of two members from each group was formed for each mission team so that communication and exchange of information would be easier among the groups. The types of projects designed by the students evolved from numerous discussions with Penn State faculty and mission planners at the Lewis Research Center Advanced Projects Office. Robotic planetary missions throughout the solar system can be considered valuable precursors to human visits and test beds for innovative technology. For example, by studying the composition of the Martian moons, scientists may be able to determine if their resources may be used or synthesized for consumption during a first human visit.

  12. CAMEX-3 MISSION REPORTS V1 (United States)

    National Aeronautics and Space Administration — The Convection And Moisture EXperiment (CAMEX)-3 Mission Reports were filed every day that an aircraft flew in support of the experiment. The reports include a short...

  13. Space Interferometry Mission Instrument Mechanical Layout (United States)

    Aaron, K.; Stubbs, D.; Kroening, K.


    The Space Interferometry Mission, planned for launch in 2006, will measure the positions of celestial objects to an unprecedented accuracy of 4x10 to the power of negative six arc (about 1 billionth of a degree).

  14. 2015 Science Mission Directorate Technology Highlights (United States)

    Seablom, Michael S.


    The role of the Science Mission Directorate (SMD) is to enable NASA to achieve its science goals in the context of the Nation's science agenda. SMD's strategic decisions regarding future missions and scientific pursuits are guided by Agency goals, input from the science community including the recommendations set forth in the National Research Council (NRC) decadal surveys and a commitment to preserve a balanced program across the major science disciplines. Toward this end, each of the four SMD science divisions -- Heliophysics, Earth Science, Planetary Science, and Astrophysics -- develops fundamental science questions upon which to base future research and mission programs. Often the breakthrough science required to answer these questions requires significant technological innovation, e.g., instruments or platforms with capabilities beyond the current state of the art. SMD's targeted technology investments fill technology gaps, enabling NASA to build the challenging and complex missions that accomplish groundbreaking science.

  15. Atrial Fibrillation During an Exploration Class Mission (United States)

    Lipsett, Mark; Hamilton, Douglas; Lemery, Jay; Polk, James


    This slide presentation reviews a possible scenario of an astronaut having Atrial Fibrillation during a Mars Mission. In the case review the presentation asks several questions about the alternatives for treatment, medications and the ramifications of the decisions.

  16. Mission statements: selling corporate values to employees. (United States)

    Klemm, M; Sanderson, S; Luffman, G


    This article investigates the reasons for the increasing use of the Company Mission Statement. Using information from a survey of U.K. companies in 1989 it looks at the types of statements issued by companies, their content, usage, and value to managers. Of particular interest is whether the mission is primarily used for the motivation of staff, or for external image building. Related issues are the value of the mission drafting process in bringing managers together to agree common objectives and the use of a hierarchy of statements to reconcile internal and external stakeholders' interests. The conclusion is that the Mission, which includes a statement of company values, is an important tool for managers to assert their leadership within the organization.

  17. Mission Specialist Scott Parazynski arrives at KSC (United States)


    STS-95 Mission Specialist Scott E. Parazynski notes the time on his watch upon his late arrival aboard a T-38 jet at the Shuttle Landing Facility. Parazynski's first plane experienced problems at the stop at Tyndall AFB and he had to wait for another jet and pilot to finish the flight to KSC. He joined other crewmembers Mission Commander Curtis L. Brown Jr., Pilot Steven W. Lindsey, Mission Specialist Stephen K. Robinson, Payload Specialist John H. Glenn Jr., senator from Ohio, Mission Specialist Pedro Duque, with the European Space Agency (ESA), and Payload Specialist Chiaki Mukai, with the National Space Development Agency of Japan (NASDA), for final pre-launch preparations. STS-95 is expected to launch at 2 p.m. EST on Oct. 29, last 8 days, 21 hours and 49 minutes, and land at 11:49 a.m. EST on Nov. 7.

  18. Software Innovation in a Mission Critical Environment (United States)

    Fredrickson, Steven


    Operating in mission-critical environments requires trusted solutions, and the preference for "tried and true" approaches presents a potential barrier to infusing innovation into mission-critical systems. This presentation explores opportunities to overcome this barrier in the software domain. It outlines specific areas of innovation in software development achieved by the Johnson Space Center (JSC) Engineering Directorate in support of NASA's major human spaceflight programs, including International Space Station, Multi-Purpose Crew Vehicle (Orion), and Commercial Crew Programs. Software engineering teams at JSC work with hardware developers, mission planners, and system operators to integrate flight vehicles, habitats, robotics, and other spacecraft elements for genuinely mission critical applications. The innovations described, including the use of NASA Core Flight Software and its associated software tool chain, can lead to software that is more affordable, more reliable, better modelled, more flexible, more easily maintained, better tested, and enabling of automation.

  19. Cloud Computing Techniques for Space Mission Design (United States)

    Arrieta, Juan; Senent, Juan


    The overarching objective of space mission design is to tackle complex problems producing better results, and faster. In developing the methods and tools to fulfill this objective, the user interacts with the different layers of a computing system.

  20. [ASSET missions at the Russian NPPs

    Energy Technology Data Exchange (ETDEWEB)

    Garnyk, N [Ministry of the Russian Federation on Atomic Energy, Moscow (Russian Federation). Div. of International Organizations and Non-Proliferation


    The activities connected with the ASSET missions and seminars which were held at the Russian nuclear power plants with the assistance of the IAEA and which facilitated the enhancement of nuclear safety culture are described.

  1. Trusteeship: shared mission for religious and laity. (United States)

    Longo, W L


    Serving as a trustee requires commitment to a particular congregation's spirit or charism and to the health care apostolate. Vatican Council II urges that laypersons take the responsibility to share with religious as partners in furthering the Church's mission.

  2. [ASSET missions at the Russian NPPs

    International Nuclear Information System (INIS)

    Garnyk, N.


    The activities connected with the ASSET missions and seminars which were held at the Russian nuclear power plants with the assistance of the IAEA and which facilitated the enhancement of nuclear safety culture are described

  3. Enterprise Information Architecture for Mission Development (United States)

    Dutra, Jayne


    This slide presentation reviews the concept of an information architecture to assist in mission development. The integrate information architecture will create a unified view of the information using metadata and the values (i.e., taxonomy).

  4. PUREX Plant deactivation mission analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.


    The purpose of the PUREX Deactivation Project mission analysis is to define the problem to be addressed by the PUREX mission, and to lay the ground work for further system definition. The mission analysis is an important first step in the System Engineering (SE) process. This report presents the results of the PUREX Deactivation Project mission analysis. The purpose of the PUREX Deactivation Project is to prepare PUREX for Decontamination and Decommissioning within a five year time frame. This will be accomplished by establishing a passively safe and environmentally secure configuration of the PUREX Plant, that can be preserved for a 10-year horizon. During deactivation, appropriate portions of the safety envelop will be maintained to ensure deactivation takes place in a safe and regulatory compliant manner

  5. Manned Mars flyby mission and configuration concept (United States)

    Young, Archie; Meredith, Ollie; Brothers, Bobby


    A concept is presented for a flyby mission of the planet. The mission was sized for the 2001 time period, has a crew of three, uses all propulsive maneuvers, and requires 442 days. Such a flyby mission results in significantly smaller vehicles than would a landing mission, but of course loses the value of the landing and the associated knowledge and prestige. Stay time in the planet vicinity is limited to the swingby trajectory but considerable time still exists for enroute science and research experiments. All propulsive braking was used in the concept due to unacceptable g-levels associated with aerobraking on this trajectory. LEO departure weight for the concept is approximately 594,000 pounds.

  6. The 1997 remote sensing mission to Kazakhstan

    International Nuclear Information System (INIS)

    Steinmaus, K.; Robert, B.; Berezin, S.A.


    In June and July of 1997, the US Department of Energy, in cooperation with the Republic of Kazakhstan Ministry of Science - Academy of Science conducted a remote sensing mission to Kazakhstan. The mission was conducted as a technology demonstration under a Memorandum of Understanding between the United States Department of Energy and the Republic of Kazakhstan's Ministry of science - Academy of Science. The mission was performed using a US Navy P-3 Orion aircraft and imaging capabilities developed by the Department of Energy's Office of Non-proliferation and National Security. The imaging capabilities consisted of two imaging pods - a synthetic aperture radar (SAR) pod and a multi sensor imaging pod (MSI). Seven experiments were conducted to demonstrate how remote sensing can be used to support city planning, land cover mapping, mineral exploration, and non-proliferation monitoring. Results of the mission will be presented

  7. The Military Missions and Means Framework

    National Research Council Canada - National Science Library

    Sheehan, Jack


    As the Department of Defense (DoD) transforms itself from a forces-based, materiel-centric Cold War posture to a capabilities-based, mission-centric asymmetric-warfare posture, it is increasingly vital that military planners...

  8. Safe passage: astronaut care for exploration missions

    National Research Council Canada - National Science Library

    Ball, John; Evans, Charles H


    .... As space missions increase in duration from months to years and extend well beyond Earth’s orbit, so will the attendant risks of working in these extreme and isolated environmental conditions...

  9. DOE and NASA joint Dark Energy mission

    CERN Multimedia


    "DOE and NASA announced their plan for a Joint Dark Energy Mission (JDEM) on October 23, 2003, at the NASA Office of Space Science Structure and Evolution of the Universe Subcommittee (SEUS) meeting" (1 paragraph).

  10. Patient preference and ease of use for different coagulation factor VIII reconstitution device scenarios: a cross-sectional survey in five European countries

    Directory of Open Access Journals (Sweden)

    Cimino E


    Full Text Available Ernesto Cimino,1 Silvia Linari,2 Mara Malerba,3 Susan Halimeh,4 Francesca Biondo,5 Martina Westfeld5 1Dipartimento Medicina Clinica e Sperimentale, Universita’ degli Studi di Napoli Federico II, Naples, Italy; 2Agenzia per l’ Emofilia, AOU Careggi di Firenze, Florence, Italy; 3Fondazione Cà Granda Ospedale Maggiore Policlinico, Centro Emofilia e Trombosi “A Bianchi Bonomi”, Milan, Italy; 4CRC Coagulation Research Centre GmbH, Duisburg, Germany; 5Pfizer Italia, Rome, Italy Introduction: Hemophilia A treatment involves replacing the deficient coagulation factor VIII. This process may involve multiple steps that might create a barrier to adherence. A new dual-chamber syringe (DCS; FuseNGo® was recently introduced with the aim of simplifying reconstitution. Aim: This study aimed to identify factors associated with adult patients’ preferences for different coagulation factor VIII reconstitution systems and to test ease of use and patient preference for the DCS. Methods: A cross-sectional survey of adults with hemophilia A in five European countries was conducted; a subset of subjects also participated in a practical testing session of the DCS. Results: Among the 299 survey participants, the device scenario requiring the least equipment and reconstitution steps (the DCS received a median preference rating of 71 out of 100 (0 being “the least desirable” and 100 “the most desirable” rating. This was significantly higher than the other scenarios (the next highest achieved a median of 50 points; P<0.001. Participants would be more likely to use this device prophylactically (P<0.001. Among the 98 participants who tested the DCS, 57% preferred this device over their current device, 26% preferred their current device, and 17% had no preference. The DCS was rated as easier to use than current treatment devices (median score 9/10 versus 7/10 for current treatment, P=0.001. Conclusion: The survey indicates that the prefilled DCS, Fuse

  11. Intensity of factor VIII treatment and the development of inhibitors in non-severe hemophilia A patients: results of the INSIGHT case-control study. (United States)

    van Velzen, A S; Eckhardt, C L; Peters, M; Leebeek, F W G; Escuriola-Ettingshausen, C; Hermans, C; Keenan, R; Astermark, J; Male, C; Peerlinck, K; le Cessie, S; van der Bom, J G; Fijnvandraat, K


    Essentials Research suggests that intensive treatment episodes may increase the risk to develop inhibitors. We performed an international nested case-control study with 298 non-severe hemophilia A patients. Surgery and a high dose of factor VIII concentrate were associated with increased inhibitor risk. Physicians need to review arguments for factor VIII dose and elective surgery extra critically. Background Inhibitor development is a major complication of treatment with factor VIII concentrates in hemophilia. Findings from studies among severe hemophilia A patients suggest that intensive treatment episodes increase the risk of developing inhibitors. Objectives We set out to assess whether intensive treatment is also associated with an increased risk of inhibitor development among non-severe hemophilia A patients. Patients/Methods We performed a nested case-control study. A total of 75 inhibitor patients (cases) and 223 control patients were selected from 2709 non-severe hemophilia A patients (FVIII:C, 2-40%) of the INSIGHT cohort study. Cases and controls were matched for date of birth and cumulative number of exposure days (EDs) to FVIII concentrates. Conditional logistic regression was used to calculate both unadjusted and adjusted odds ratios (aOR); the latter were adjusted for a priori specified confounders. Results Peak treatment of 5 or 10 consecutive EDs did not increase inhibitor risk (aOR, 1.0; 95% confidence interval (CI), 0.4-2.5; and aOR, 1.8; CI, 0.6-5.5, respectively). Both surgical intervention (aOR, 4.2; CI, 1.7-10.3) and a high mean dose (> 45 IU kg -1 /ED) of FVIII concentrate (aOR, 7.5; CI, 1.6-35.6) were associated with an increased inhibitor risk. Conclusions Our findings suggest that high-dose FVIII treatment and surgery increase the risk of inhibitor development in non-severe hemophilia A. Together with the notion that non-severe hemophilia A patients are at a lifelong risk of inhibitor development, we suggest that in the future physicians


    International Nuclear Information System (INIS)

    Henley, David B.; Shelton, Robin L.


    We present an all-sky catalog of diffuse O VII and O VIII line intensities, extracted from archival XMM-Newton observations. This catalog supersedes our previous catalog, which covered the sky between l = 120° and l = 240°. We attempted to reduce the contamination from near-Earth solar wind charge exchange (SWCX) emission by excluding times of high solar wind proton flux from the data. Without this filtering, we were able to extract measurements from 1868 observations. With this filtering, nearly half of the observations became unusable, and only 1003 observations yielded measurements. The O VII and O VIII intensities are typically ∼2-11 and ∼ –2 s –1 sr –1 (line unit, L.U.), respectively, although much brighter intensities were also recorded. Our data set includes 217 directions that have been observed multiple times by XMM-Newton. The time variation of the intensities from such directions may be used to constrain SWCX models. The O VII and O VIII intensities typically vary by ∼ 10 L.U. were observed. We compared our measurements with models of the heliospheric and geocoronal SWCX. The heliospheric SWCX intensity is expected to vary with ecliptic latitude and solar cycle. We found that the observed oxygen intensities generally decrease from solar maximum to solar minimum, both at high ecliptic latitudes (which is as expected) and at low ecliptic latitudes (which is not as expected). The geocoronal SWCX intensity is expected to depend on the solar wind proton flux incident on the Earth and on the sightline's path through the magnetosheath. The intensity variations seen in directions that have been observed multiple times are in poor agreement with the predictions of a geocoronal SWCX model. We found that the oxygen lines account for ∼40%-50% of the 3/4 keV X-ray background that is not due to unresolved active galactic nuclei, in good agreement with a previous measurement. However, we found that this fraction is not easily explainable by a

  13. Planning for Planetary Science Mission Including Resource Prospecting, Phase II (United States)

    National Aeronautics and Space Administration — Advances in computer-aided mission planning can enhance mission operations and science return for surface missions to Mars, the Moon, and beyond. While the...

  14. Protection of Shipping: A Forgotten Mission with Many New Challenges

    National Research Council Canada - National Science Library

    Grubb, Michael C


    ..." mission status, often leading to devastating losses of shipping when war came. Today, the protection of shipping mission still finds itself behind more high-profile missions such as strike warfare and ballistic missile defense...

  15. A new propulsion concept for interplanetary missions (United States)

    Dujarric, C.


    When tons of payload must be brought back from the planets to Earth, the current launch-system technology hits size limitations. The huge Saturn-V launcher that enabled the Apollo missions to go to the Moon would be dwarfed by a single launcher capable of sending men to a destination like Mars and bringing them back. Keeping interplanetary missions within a reasonable size and cost therefore requires technological progress in terms of both vehicle weight reduction and propulsion efficiency.

  16. Blast-Off on Mission: SPACE (United States)


    Part of NASA's mission is to inspire the next generation of explorers. NASA often reaches children - the inventors of tomorrow - through teachers, reporters, exhibit designers, and other third-party entities. Therefore, when Walt Disney Imagineering, the creative force behind the planning, design, and construction of Disney parks and resorts around the world, approached NASA with the desire to put realism into its Mission: SPACE project, the Agency was happy to offer its insight.

  17. Mission statement for the Engineering Test Facility

    International Nuclear Information System (INIS)


    This Mission Statement defines the ETF activity during its operating life. The results of those operations must provide the data, knowledge, experience, and confidence to continue to the next steps beyond ETF in making fusion power a viable energy option. The results from the ETF mission (operations are assumed to start early in the 1990's) are to bridge the gap between the base of magnetic fusion knowledge at the start of operations and that reqired to design the EPR/DEMO devices

  18. Tank waste remediation system mission analysis report

    International Nuclear Information System (INIS)

    Acree, C.D.


    This document describes and analyzes the technical requirements that the Tank Waste Remediation System (TWRS) must satisfy for the mission. This document further defines the technical requirements that TWRS must satisfy to supply feed to the private contractors' facilities and to store or dispose the immobilized waste following processing in these facilities. This document uses a two phased approach to the analysis to reflect the two-phased nature of the mission

  19. Bobby Fong: Man on a Mission (United States)

    Fong, Colin


    Bobby Fong, was president of Ursinus College until his death in September 2014 and is the only person to have served twice as chair of the AAC&U Board of Directors. In this article, his son Collin presents remarks made at the memorial service for his father. Collin describes his father as a man with a mission, and that mission was to make the…

  20. Do the Metrics Make the Mission? (United States)


    view that, “multidimensional peacekeeping missions are complex with many unknown variables and fall victim to mission creep once a peacekeeping...techniques for breeding and vaccinating cattle . Since the vaccination program was implemented, over “nine million heads of livestock have received...Procurement of equipment, fish feed and brood stock is in progress, while 1,500 fish pond owners have been supplied with fish fingerlings. As a result