Roles of Werner syndrome protein in protection of genome integrity

DEFF Research Database (Denmark)

Rossi, Marie L; Ghosh, Avik K; Bohr, Vilhelm A

2010-01-01

Werner syndrome protein (WRN) is one of a family of five human RecQ helicases implicated in the maintenance of genome stability. The conserved RecQ family also includes RecQ1, Bloom syndrome protein (BLM), RecQ4, and RecQ5 in humans, as well as Sgs1 in Saccharomyces cerevisiae, Rqh1...... in Schizosaccharomyces pombe, and homologs in Caenorhabditis elegans, Xenopus laevis, and Drosophila melanogaster. Defects in three of the RecQ helicases, RecQ4, BLM, and WRN, cause human pathologies linked with cancer predisposition and premature aging. Mutations in the WRN gene are the causative factor of Werner...

Interview with Mike Parker Pearson

Directory of Open Access Journals (Sweden)

Thomas J. T. Williams

2013-02-01

Full Text Available Mike Parker Pearson is the Institute of Archaeology’s newly appointed Professor of British Later Prehistory. In this interview he reflects on his experience at the birth of post-processualism, current problems and opportunities in modern archaeology, and the subject for which he is best known: Stonehenge.

Autogrammid, oma aja märk / Mike Lawrence

Index Scriptorium Estoniae

Lawrence, Mike

2004-01-01

Autogrammide kogumisest, nende ehtsusest, sportlastele kuulunud esemete kollektsioneerimisest. Lisatud: Kollektsionääride maiuspalu. Autor Mike Lawrence on oksjonifirma Bonhams/Brooks konsultant, ajakirjanik

Fragmentation inside atomic cooling haloes exposed to Lyman-Werner radiation

Science.gov (United States)

Regan, John A.; Downes, Turlough P.

2018-04-01

Supermassive stars born in pristine environments in the early Universe hold the promise of being the seeds for the supermassive black holes observed as high redshift quasars shortly after the epoch of reionisation. H2 suppression is thought to be crucial in order to negate normal Population III star formation and allow high accretion rates to drive the formation of supermassive stars. Only in the cases where vigorous fragmentation is avoided will a monolithic collapse be successful, giving rise to a single massive central object. We investigate the number of fragmentation sites formed in collapsing atomic cooling haloes subject to various levels of background Lyman-Werner flux. The background Lyman-Werner flux manipulates the chemical properties of the gas in the collapsing halo by destroying H2. We find that only when the collapsing gas cloud shifts from the molecular to the atomic cooling regime is the degree of fragmentation suppressed. In our particular case, we find that this occurs above a critical Lyman-Werner background of J ˜ 10 J21. The important criterion being the transition to the atomic cooling regime rather than the actual value of J, which will vary locally. Once the temperature of the gas exceeds T ≳ 104 K and the gas transitions to atomic line cooling, then vigorous fragmentation is strongly suppressed.

Werner Heisenberg, 5 December 1901 - 1 February 1976

International Nuclear Information System (INIS)

Mott, N.; Peierls, R.

1977-01-01

An account is given of the life and work of Werner Heisenberg, with particular reference to his contribution to quantum mechanics and the formulation of the uncertainty principle. The development of atomic energy in Germany during the war is described, and the part played by Heisenberg in German post-war science. (U.K.)

An empirical study of the nuclear explosion-induced lightning seen on IVY-MIKE

Science.gov (United States)

Colvin, J. D.; Mitchell, C. K.; Greig, J. R.; Murphy, D. P.; Pechacek, R. E.; Raleigh, M.

1987-05-01

We report the results of a unique study of the lightninglike phenomena that were seen to accompany the MIKE shot of operation IVY on October 31 1952. MIKE was a thermonuclear surface burst yielding 10.4 MT, which took place on Enewetak Atoll. During the period of approximately 10 ms after detonation, five discrete luminous channels were seen to start from the ground or sea surface at a distance of approximately 1 km from the burst point and to grow up into the clouds. We have reexamined the original photographic records of IVY-MIKE, obtaining effective brightnesses (optical powers per unit length) for the luminous channels at different altitudes as functions of time. The absolute calibration for the MIKE records was deduced by comparison with the photographic records of other events of that era, laboratory measurements of film sensitivity, and use of atmospheric transmission data taken just prior to the MIKE event. Errors in this analysis lead to an uncertainty of a factor of ˜2 in the brightnesses of the luminous channels. In the laboratory we have used laser-guided electric discharges to create long (100 cm), arclike plasma channels to simulate the observed luminous channels and to allow determination of an empirical relation between the brightness of the channel and the electric current flowing in the channel. These laboratory discharges had peak currents up to 100 kA and periods of ˜2 ms. Spectroscopic analysis showed that the luminous channels consisted primarily of normal air plasma with typical ground-level contaminants. Photographic studies showed that these long-duration discharges are unstable to the m = 1 magnetohydrodynamic (MHD) instability and become severely distorted in less than 1 ms. By direct comparison of the luminous channels seen at MIKE and the laboratory discharges, we deduce: (1) the peak current in the prominent (brightest) channel at MIKE was between 200 and 600 kA. Here the most likely value of the peak current was 250±50 kA, but

Heinz Werner: His Life, Ideas, and Contributions to Developmental Psychology in the First Half of the 20th Century.

Science.gov (United States)

Ostler, Teresa

2016-01-01

The author provides an overview of Heinz Werner's life and contributions to the field of developmental psychology during the first half of the 20th century. She focuses on his early work in Vienna and Munich as well as his tenure at the Psychological Institute in Hamburg, up through the time when he became a named Professor in Psychology at Clark University. Recognized as one of the founders of developmental psychology, Heinz Werner worked in the areas of perceptual development, comparative psychology, and symbol formation. Versatile in rigorous experimental methodologies, and in observational and phenomenological methodologies, Werner's approach to development stood in contrast to other approaches of development, both past and current. For Werner, development was a heuristic, a way of looking at processes in a variety of domains, including ontogeny, phylogeny, microgenesis, biology, developmental psychopathology, neuropsychology, and comparative psychology. Werner viewed development as proceeding from a state of relative globality and lack of differentiation to a state of increasing differentiation, articulation, and hierarchical integration, but he also stressed that individuals can function at different developmental levels under different times and conditions. Werner's holistic, organismic, comparative, and contextual approach to development transcended interdisciplinary boundaries, allowing him to study the interrelatedness between thought, language, feeling, perception, and culture.

Simulating Wind Driven Waves in the Strait of Hormuz using MIKE21 (Simulasi Gelombang Angin di Selat Hormuz Menggunakan MIKE21

Directory of Open Access Journals (Sweden)

Faeghe Eslami Mehdiabadi

2015-03-01

Full Text Available Daerah pesisir di bumi adalah salah satu zona paling dinamis yang dipengaruhi oleh berbagai parameter seperti gelombang, arus, dan badai. Untuk mengelola serta mengkontrol zona tersebut adalah penting untuk mempelajari hidrodinamika daerah. Penelitian ini menggunakan MIKE 21/3 coupled Model FM untuk melihat gelombang (wind driven waves di sekitar Pulau Larak di Selat Hormuz. Untuk mensimulasikan pola gelombang di wilayah tersebut digunakan irregular triangular grid.  Pola arus di sekitar pulau dipelajari untuk jangka waktu satu tahun. Ditemukan bahwa gelombang yang ditimbulkan karena arus di sekitar pantai utara pulau relatif lemah. Terlihat pula bahwa gelombang yang ada di daerah tersebut terutama ke arah timur laut. Tinggi gelombang rata-rata di surfzone adalah sekitar 0,5 m., Dengan kecepatan arus sekitar 0,2 m.s-1. Mengingat angin menang dan arah gelombang, disimpulkan bahwa pantai utara Pulau Larak tempat yang cocok untuk konstruksi pelabuhan dan kegiatan memancing. Kata kunci: gelombang, arus, MIKE, Pulau Larak Coastal areas on earth are among the most dynamic zones which affected by different parameters such as waves, currents, and storms. To manage and control such a zone it is essential to study the hydrodynamic of the area. MIKE 21/3 Coupled Model FM was used to investigate the wind driven waves around Larak Island located in the Strait of Hormuz. To simulate the pattern of the wave in the area irregular triangular grid was applied. The pattern of current around the Island was studied for a one year period of simulation. It was found that the current induced wave break around the Northern coast of the Island is relatively weak. It was also observed that the prevailed wave in the area is mainly toward the Northeast. The averaged wave height in the surfzone is about 0.5 m., with the current velocity of about 0.2 m.s-1. Considering the prevailed wind and wave direction, it was concluded that the northern coasts of the Larak Island are

Werner-Wheeler mass tensor for fusionlike configuration

International Nuclear Information System (INIS)

Gherghescu, R.A.; Poenaru, D.N.

2005-01-01

The Werner-Wheeler approach is used to calculate the components of the mass tensor for a binary configuration of two intersected spheroids. Four free coordinates form the deformation space: the small semiaxis of the projectile, the two semiaxis ratios of the spheroids, and the distance between centers. A correction term is also calculated, due to the center of mass motion. Final results are presented for the fusion channel 54 Cr+ 240 Pu, and all possible couplings are analyzed

Werner Herzog - saksa kino atleet ja aadlik / Mart Rummo

Index Scriptorium Estoniae

Rummo, Mart

2002-01-01

Alates 6. juunist näidatakse Katariina kirikus kuuel õhtul algusega kell 22 Werner Herzogi (1942) filme. Väljavõtteid W. Herzogi poolt 1999. aastal Cannes'i festivali järel antud intervjuust, kus juttu ka režissööri suhetest näitleja Klaus Kinskiga, millest kõneleb ka Tallinnas näidatav "Minu armas vaenlane"

Linkage of mike she to wetland-dndc for carbon budgeting and anaerobic biogeochemistry simulation

Science.gov (United States)

Jianbo Cui; Changsheng Li; Ge Sun; Carl Trettin

2005-01-01

This study reports the linkage between MIKE SHE and Wetland-DNDC for carbon dynamics and greenhouse gases (GHGs) emissions simulation in forested wetland.Wet1and-DNDC was modified by parameterizing management measures, refining anaerobic biogeochemical processes, and was linked to the hydrological model - MIKE SHE. As a preliminary application, we simulated the effect...

Werner Karl Heisenberg (1901-1976)

International Nuclear Information System (INIS)

Kvasnica, J.

1992-01-01

The life's career of Werner Karl Heisenberg is described with emphasis on his creative development and cooperation with many other prominent physicists in the field of the quantum theory of atoms. In 1925, Heisenberg modified Bohr's quantum rule; in 1927 he formulated the uncertainty principle which puts some restrictions on the simultaneous determination of the position and momentum. In 1928, Heisenberg set up the quantum theory of ferromagnetism, which still underlies all theories of magnetic properties of substances. Soon after Chadwick's discovery of the neutron (1932), Heisenberg introduced the concept of the isospin - he interpreted the proton and the neutron as one particle (nucleon) in two charge states. Heisenberg's professional and pedagogical activities during and after the 2nd world war are also described. (Z.S.). 5 refs

Response to formal comment on Myhrvold (2016) submitted by Griebeler and Werner (2017).

Science.gov (United States)

Myhrvold, Nathan P

2018-01-01

Griebeler and Werner offer a formal comment on Myhrvold, 2016 defending the conclusions of Werner and Griebeler, 2014. Although the comment criticizes several aspects of methodology in Myhrvold, 2016, all three papers concur on a key conclusion: the metabolism of extant endotherms and ectotherms cannot be reliably classified using growth-rate allometry, because the growth rates of extant endotherms and ectotherms overlap. A key point of disagreement is that the 2014 paper concluded that despite this general case, one can nevertheless classify dinosaurs as ectotherms from their growth rate allometry. The 2014 conclusion is based on two factors: the assertion (made without any supporting arguments) that the comparison with dinosaurs must be restricted only to extant sauropsids, ignoring other vertebrate groups, and that extant sauropsid endotherm and ectotherm growth rates in a data set studied in the 2014 work do not overlap. The Griebeler and Werner formal comment presents their first arguments in support of the restriction proposition. In this response I show that this restriction is unsupported by established principles of phylogenetic comparison. In addition, I show that the data set studied in their 2014 work does show overlap, and that this is visible in one of its figures. I explain how either point effectively invalidates the conclusion of their 2014 paper. I also address the other methodological criticisms of Myhrvold 2016, and find them unsupported.

Immortalization of Werner syndrome and progeria fibroblasts

International Nuclear Information System (INIS)

Saito, H.; Moses, R.E.

1991-01-01

Human fibroblast cells from two different progeroid syndromes, Werner syndrome (WS) and progeria, were established as immortalized cell lines by transfection with plasmid DNA containing the SV40 early region. The lineage of each immortalized cell line was confirmed by VNTR analysis. Each of the immortalized cell lines maintained its original phenotype of slow growth. DNA repair ability of these cells was also studied by measuring sensitivity to killing by uv or the DNA-damaging drugs methyl methansulfonate, bleomycin, and cis-dichlorodiamine platinum. The results showed that both WS and progeria cells have normal sensitivity to these agents

Kriis kui võimalus / Mike Seymour ; interv. Kristo Kiviorg

Index Scriptorium Estoniae

Seymour, Mike

2008-01-01

Riskijuhtimise ja kriisikommunikatsiooni spetsialist Mike Seymouri sõnul on infoühiskonna areng pannud ettevõtted olukorda, kus nad peavad olema iga hetk valmis sattuma enda suhtes vaenulikult meelestatud avalikkuse tähelepanu alla. Vt. samas: Urve Vilk. Eesti ettevõtete valmisolek kriisikommunikatsiooniks on madal

Werner Jaeger's "Paideia" and His 'Third Humanism'

Science.gov (United States)

Horn, Christoph

2018-01-01

Werner Jaeger (1888-1961) was at his time the most brilliant and the most influential German classicist. His most important project was a tripartite study that he finally published under the title of "Paideia. Die Formung des griechischen Menschen" (1933-1947). "Paideia" was much more than a detailed scholarly book on pedagogy…

Sufficient and necessary condition of separability for generalized Werner states

International Nuclear Information System (INIS)

Deng Dongling; Chen Jingling

2009-01-01

In a celebrated paper [Optics Communications 179, 447, 2000], A.O. Pittenger and M.H. Rubin presented for the first time a sufficient and necessary condition of separability for the generalized Werner states. Inspired by their ideas, we generalized their method to a more general case. We obtain a sufficient and necessary condition for the separability of a specific class of N d-dimensional system (qudits) states, namely special generalized Werner state (SGWS): W [d N ] (v)=(1-v)(I (N) )/(d N ) +v|ψ d N > d N |, where |ψ d N >=Σ i=0 d-1 α i |i...i> is an entangled pure state of N qudits system and α i satisfies two restrictions: (i) Σ i=0 d-1 α i α i *=1; (ii) Matrix 1/d (I (1) +TΣ i≠j α i |i> j *), where T=Min i≠j {1/|α i α j |}, is a density matrix. Our condition gives quite a simple and efficiently computable way to judge whether a given SGWS is separable or not and previously known separable conditions are shown to be special cases of our approach

WERNER SYNDROME: A NEW CASE REPORT

Directory of Open Access Journals (Sweden)

Faida Ajili

2013-10-01

Full Text Available “Werner’s syndrome” or premature aging syndrome is a rare autosomal recessive genetic disease. It is responsible of several complications related to age, including atherosclerosis and association with cancer. We report the case of a 36 year-old-patient, admitted to department of Internal Medicine of the military hospital of Tunis for suspicion of systemic sclerosis. The patient had all the major signs of Werner syndrome (bilateral cataract, sclerotic skin, “bird face”, baldness, small size, parental consanguinity and 4 minor signs (type 2 diabetes, hypogonadism, squeaky voice, and flat feet. She has also a brother with the same morphotype died at the age of 32 by a myocardial infarction. The current follow-up time is 9 years..

Puudega inimesed tahavad tööd teha / Mike Buckley

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Buckley, Mike

2003-01-01

PHARE nõuniku Mike Buckley hinnangul kipuvad toetuste- ja pensionisüsteemid eeldama, et puudega inimesed ei ole suutelised töötama, samas näitavad küsitlused, et kolmandik neist sooviks töötada

Generation of Werner states and preservation of entanglement in a noisy environment

Energy Technology Data Exchange (ETDEWEB)

Jakobczyk, Lech [Institute of Theoretical Physics, University of Wroclaw, Pl. M. Borna 9, 50-204 Wroclaw (Poland)]. E-mail: ljak@ift.uni.wroc.pl; Jamroz, Anna [Institute of Theoretical Physics, University of Wroclaw, Pl. M. Borna 9, 50-204 Wroclaw (Poland)

2005-12-05

We study the influence of noisy environment on the evolution of two-atomic system in the presence of collective damping. Generation of Werner states as asymptotic stationary states of evolution is described. We also show that for some initial states the amount of entanglement is preserved during the evolution.

Gram-scale synthesis of the p38α MAPK-inhibitor VX-745 for preclinical studies into Werner syndrome.

Science.gov (United States)

Bagley, Mark C; Davis, Terence; Dix, Matthew C; Fusillo, Vincenzo; Pigeaux, Morgane; Rokicki, Michal J; Kipling, David

2010-09-01

The ATP-competitive p38α MAPK inhibitor VX-745 exhibits an exquisite kinase selectivity profile, is effective in blocking p38 stress signaling in Werner syndrome dermal fibroblasts, has efficacy in clinical trials and may have therapeutic value against Werner syndrome. Previous synthetic routes, however, have only resulted in milligram quantities suitable for cell-based studies, whereas gram quantities would be required for in vivo use. Microwave irradiation using a stop-flow monomodal microwave reactor has been found to facilitate scale-up of the synthesis of VX-745. Ullmann-type C-S bond formation using thiophenol, chloropyridazine, copper(I) catalyst and diol ligand proceeds rapidly and efficiently in this apparatus for elaboration to the pyrimido[1,6-b]pyridazinone core of VX-745 on gram scale and with good overall yield. This method delivers the p38 inhibitor VX-745 in sufficient quantities for preclinical studies to rescue the aging phenotype in Werner syndrome.

An Unexpected Cause of Pelvic Pain in a Pubertal Case: Herlyn-Werner-Wunderlich Syndrome

Directory of Open Access Journals (Sweden)

Yasemin Kayadibi

2014-03-01

Full Text Available Uterovaginal duplication with imperforated hemivagina is a rare type of Mullerian anomaly. If ipsilateral renal agenesis is associated with this complex genital malformation, it is called Herlyn-Werner-Wunderlich syndrome. Clinical presentations of this syndrome include pelvic pain and mass effect due to obstructed hemivagina in pubertal adolescents and adults. Hematocolpos, even after menstruation period, leads to misdiagnosis. Laparotomy is the gold standard for the diagnosis, however, magnetic resonance imaging has an accuracy upto 100% in evaluating uterovajinal anatomy. In this article, we aimed to present ultrasonographic and magnetic resonance imaging findings in a patient with Herlyn-Werner-Wun derlich syndrome who presented with cyclic pelvic pain. (The Me­di­cal Bul­le­tin of Ha­se­ki 2014; 52: 60-3

The Relationship between Werner Syndrome and Sinonasal Malignant Melanoma: Two Sibling Cases of Werner Syndrome with Malignant Melanoma

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Yoshinori Kadowaki

2017-01-01

Full Text Available Werner syndrome (WS is an autosomal recessive disease characterized by premature aging. Malignant tumors such as thyroid carcinoma and malignant melanoma occur frequently in WS patients. We describe 2 siblings with WS who suffered from sinonasal malignant melanoma (MM. Both patients initially experienced nasal obstruction and recurrent nasal bleeding and died within 2 years of the diagnosis of MM. Otolaryngologists should recognize that WS patients have a high risk for head and neck malignant disease, particularly sinonasal MM, even if they are aged below the expected age range and undergo periodic examinations. Furthermore, it is important that WS patients are aware that a prompt nasal examination is indicated if they experience continuous nasal obstruction or recurrent nasal bleeding.

Going Back to School: An Interview with Mike Rose

Science.gov (United States)

Adams, Peter

2017-01-01

Mike Rose is a professor in the UCLA Graduate School of Education and Information Studies. He has taught in a wide range of educational settings - from elementary school to adult literacy and job training programs--and has directed an Educational Opportunity (EOP) tutorial center. He is an author and member of the National Academy of Education and…

Generation of Werner-like stationary states of two qubits in a thermal reservoir

International Nuclear Information System (INIS)

Jakobczyk, Lech

2010-01-01

The dynamics of entanglement between two-level atoms immersed in the common photon reservoir at finite temperature is investigated. It is shown that in the regime of strong correlations there are nontrivial asymptotic states which can be interpreted in terms of thermal generalization of Werner states.

Generation of Werner-like stationary states of two qubits in a thermal reservoir

Energy Technology Data Exchange (ETDEWEB)

Jakobczyk, Lech, E-mail: ljak@ift.uni.wroc.p [Institute of Theoretical Physics, University of Wroclaw, Plac Maxa Borna 9, 50-204 Wroclaw (Poland)

2010-01-14

The dynamics of entanglement between two-level atoms immersed in the common photon reservoir at finite temperature is investigated. It is shown that in the regime of strong correlations there are nontrivial asymptotic states which can be interpreted in terms of thermal generalization of Werner states.

Femi, Brake Mechanic: Kinesthetic Learning and Mike Rose's "Remedial" Education

Science.gov (United States)

Martin, Tom

2012-01-01

Mike Rose, author of "The Mind at Work," extols both the wholesome, pragmatic qualities of handcraft and the implicit intellectual skills required of its practitioners. His recent article, "Rethinking Remedial Education and the Academic-Vocational Divide," is titled with a call to action; in these few words alone, Rose problematizes the polar…

Hydrological simulation of Sperchios River basin in Central Greece using the MIKE SHE model and geographic information systems

Science.gov (United States)

Paparrizos, Spyridon; Maris, Fotios

2017-05-01

The MIKE SHE model is able to simulate the entire stream flow which includes direct and basic flow. Many models either do not simulate or use simplistic methods to determine the basic flow. The MIKE SHE model takes into account many hydrological data. Since this study was directed towards the simulation of surface runoff and infiltration into saturated and unsaturated zone, the MIKE SHE is an appropriate model for reliable conclusions. In the current research, the MIKE SHE model was used to simulate runoff in the area of Sperchios River basin. Meteorological data from eight rainfall stations within the Sperchios River basin were used as inputs. Vegetation as well as geological data was used to perform the calibration and validation of the physical processes of the model. Additionally, ArcGIS program was used. The results indicated that the model was able to simulate the surface runoff satisfactorily, representing all the hydrological data adequately. Some minor differentiations appeared which can be eliminated with the appropriate adjustments that can be decided by the researcher's experience.

Nucleolin inhibits G4 oligonucleotide unwinding by Werner helicase.

Directory of Open Access Journals (Sweden)

Fred E Indig

Full Text Available The Werner protein (WRNp, a member of the RecQ helicase family, is strongly associated with the nucleolus, as is nucleolin (NCL, an important nucleolar constituent protein. Both WRNp and NCL respond to the effects of DNA damaging agents. Therefore, we have investigated if these nuclear proteins interact and if this interaction has a possible functional significance in DNA damage repair.Here we report that WRNp interacts with the RNA-binding protein, NCL, based on immunoprecipitation, immunofluorescent co-localization in live and fixed cells, and direct binding of purified WRNp to nucleolin. We also map the binding region to the C-terminal domains of both proteins. Furthermore, treatment of U2OS cells with 15 µM of the Topoisomerase I inhibitor, camptothecin, causes the dissociation of the nucleolin-Werner complex in the nucleolus, followed by partial re-association in the nucleoplasm. Other DNA damaging agents, such as hydroxyurea, Mitomycin C, and aphidicolin do not have these effects. Nucleolin or its C-terminal fragment affected the helicase, but not the exonuclease activity of WRNp, by inhibiting WRN unwinding of G4 tetraplex DNA structures, as seen in activity assays and electrophoretic mobility shift assays (EMSA.These data suggest that nucleolin may regulate G4 DNA unwinding by WRNp, possibly in response to certain DNA damaging agents. We postulate that the NCL-WRNp complex may contain an inactive form of WRNp, which is released from the nucleolus upon DNA damage. Then, when required, WRNp is released from inhibition and can participate in the DNA repair processes.

Stochastic simulations of normal aging and Werner's syndrome.

KAUST Repository

Qi, Qi

2014-04-26

Human cells typically consist of 23 pairs of chromosomes. Telomeres are repetitive sequences of DNA located at the ends of chromosomes. During cell replication, a number of basepairs are lost from the end of the chromosome and this shortening restricts the number of divisions that a cell can complete before it becomes senescent, or non-replicative. In this paper, we use Monte Carlo simulations to form a stochastic model of telomere shortening to investigate how telomere shortening affects normal aging. Using this model, we study various hypotheses for the way in which shortening occurs by comparing their impact on aging at the chromosome and cell levels. We consider different types of length-dependent loss and replication probabilities to describe these processes. After analyzing a simple model for a population of independent chromosomes, we simulate a population of cells in which each cell has 46 chromosomes and the shortest telomere governs the replicative potential of the cell. We generalize these simulations to Werner\\'s syndrome, a condition in which large sections of DNA are removed during cell division and, amongst other conditions, results in rapid aging. Since the mechanisms governing the loss of additional basepairs are not known, we use our model to simulate a variety of possible forms for the rate at which additional telomeres are lost per replication and several expressions for how the probability of cell division depends on telomere length. As well as the evolution of the mean telomere length, we consider the standard deviation and the shape of the distribution. We compare our results with a variety of data from the literature, covering both experimental data and previous models. We find good agreement for the evolution of telomere length when plotted against population doubling.

Magnetic resonance imaging diagnosis of Herlyn-Werner-Wunderlich syndrome

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Taruna Yadav

2017-01-01

Full Text Available Herlyn-Werner-Wunderlich syndrome (HWW is a triad of didelphys uterus, obstructed hemivagina, and ipsilateral renal agenesis. It is a combined anomaly of Mullerian and mesonephric ducts. It usually presents in adolescent females after menarche with nonspecific symptoms of pelvic pain, dysmenorrhea, and rarely a palpable pelvic mass. We report here, a case of an 18-year-old female presenting with complaints of lower abdominal pain and dysmenorrhea where magnetic resonance imaging (MRI confirmed the diagnosis of HWW syndrome. MRI is the imaging modality of choice for diagnosis of HWW syndrome and associated complications such as endometriosis.

Samuel A. Werner Pioneer of Neutron Interferometry

International Nuclear Information System (INIS)

Klein, Anthony

2005-01-01

Full text: In 1975, Sam Werner and his collaborators on the staff of the Scientific Laboratory of the Ford Motor Company carried out one of the pioneering experiments in neutron interferometry at the 2MW University of Michigan research reactor. It was the famous COW Experiment on gravitationally induced quantum interference. Shortly thereafter he moved to the University of Missouri in Columbia, to set up a program of neutron scattering research, including neutron interferometry. In the 25 years until his retirement a large number of beautiful experiments have been performed by Sam, with his group, his numerous students and many international collaborators. The Interferometry and Coherence session at this conference has been organized in his honour and the collected papers presented by his friends, collaborators and former students form his Festschrift. (author)

Spring Research Festival Features Visit from FCPS Superintendent | Poster

Science.gov (United States)

One of the highlights of the 19th annual Spring Research Festival (SRF), held May 4–7, was a visit from Terry Alban, Ph.D., superintendent of Frederick County Public Schools (FCPS), and Mike Markoe, deputy superintendent, FCPS. They toured the event on May 7, talking to researchers and students about their posters. “Dr. Alban was very interested in hearing what the Werner H.

Mike Leigh' abordi-draama võitis Veneetsias Kuldlõvi / Tiit Tuumalu

Index Scriptorium Estoniae

Tuumalu, Tiit, 1971-

2004-01-01

Veneetsia 61. filmifestivali võitjad : Kuldlõvi sai inglase Mike Leigh "Vera Drake" (nimiosa eest ka parima naisnäitleja Coppa Volpi Imelda Stauntonile), Hõbelõvi läks hispaanlase Alejandro Amenabari filmile "Merele" (siit ka parima meesnäitleja au Javier Bardemile), režii eriauhinna sai Kim Ki-duk Lõuna-Koreast filmiga "Tühi maja" ("Bin jip")

Development of a GPU-accelerated MIKE 21 Solver for Water Wave Dynamics

DEFF Research Database (Denmark)

Aackermann, Peter Edward; Pedersen, Peter Juhler Dinesen; Engsig-Karup, Allan Peter

2013-01-01

With encouragement by the company DHI are the aim of this B.Sc. thesis1 to investigate, whether if it is possible to accelerate the simulation speed of DHIs commercial product MIKE 21 HD, by formulating a parallel solution scheme and implementing it to be executed on a CUDA-enabled GPU (massive...

Investigation of the dew-point temperature scale maintained at the MIKES

Science.gov (United States)

Heinonen, Martti

1999-01-01

For the investigation of the dew-point temperature scale realized by the MIKES primary dew-point generator, a two-pressure generator and a dew-point indicator based on condensation in a cooled coil were constructed and tested. In addition, a chilled mirror hygrometer was validated by means of an uncertainty analysis. The comparison of these systems was focused on the dew-point temperature range from 0957-0233/10/1/010/img1 to 0957-0233/10/1/010/img2 but measurements were made up to 0957-0233/10/1/010/img3. The generator systems were compared using a dew-point comparator based on two relative humidity sensors. According to the results of the comparisons, the differences between the measurement systems were less than 0957-0233/10/1/010/img4, while the expanded uncertainty of the MIKES generator was between 0957-0233/10/1/010/img5 and 0957-0233/10/1/010/img6. The uncertainty of the other systems was from 0957-0233/10/1/010/img7 to 0957-0233/10/1/010/img8. It was concluded that the dew-point temperature scale was not dependent on the realization method.

Genetics and aging; the Werner syndrome as a segmental progeroid syndrome.

Science.gov (United States)

Martin, G M

1985-01-01

The maximum lifespan potential is a constitutional feature of speciation and must be subject to polygenic controls acting both in the domain of development and in the domain of the maintenance of macromolecular integrity. The enormous genetic heterogeneity that characterizes our own species, the complexities of numerous nature-nurture interactions, and the quantitative and qualitative variations of the senescent phenotype that are observed suggest that precise patterns of aging in each of us may be unique. Patterns of aging may also differ sharply among species (for example, semelparous vs. multiparous mammals). Some potential common denominators, however, allow one to identify progeroid syndromes in man that could lead to the elucidation of important pathways of gene action. (The suffix "-oid" means "like"; it does not mean identity.) Unimodal progeroid syndromes (eg., familial dementia of the Alzheimer type, an autosomal dominant) can help us understand the pathogenesis of a particular aspect of the senescent phenotype of man. Segmental progeroid syndromes (eg. the Werner syndrome, an autosomal recessive) may be relevant to multiple aspects of the senescent phenotype. Some results of research on the Werner syndrome may be interpreted as support for "peripheral" as opposed to "central" theories of aging; they are consistent with the view that gene action in the domain of development (adolescence, in this instance) can set the stage for patterns of aging in the adult; they point to the importance of mesenchymal cell populations in the pathogenesis of age-related disorders; finally, they underscore the role of chromosomal instability, especially in the pathogenesis of neoplasia.

Neutron interferometry: The pioneering contributions of Samuel A. Werner

International Nuclear Information System (INIS)

Klein, A.G.

2006-01-01

In 1975, Sam Werner, while on the staff of the Scientific Laboratory of the Ford Motor Company, and his collaborators from Purdue University, Roberto Colella and Albert Overhauser, carried out one of the pioneering experiments in neutron interferometry at the 2 MW University of Michigan research reactor. It was the famous COW Experiment [Colella et al., Phys. Rev. Lett. 34 (1975) 1472] on gravitationally induced quantum interference. Shortly thereafter he moved to University of Missouri in Columbia, to set up a program of neutron scattering research, including neutron interferometry. In the 25 years until his retirement a large number of beautiful experiments have been performed by Sam, with his group, his numerous students and many international collaborators. This work and its history are briefly reviewed in this paper

Werner complex deficiency in cells disrupts the Nuclear Pore Complex and the distribution of lamin B1.

Science.gov (United States)

Li, Zhi; Zhu, Yizhou; Zhai, Yujia; R Castroagudin, Michelle; Bao, Yifei; White, Tommy E; Glavy, Joseph S

2013-12-01

From the surrounding shell to the inner machinery, nuclear proteins provide the functional plasticity of the nucleus. This study highlights the nuclear association of Pore membrane (POM) protein NDC1 and Werner protein (WRN), a RecQ helicase responsible for the DNA instability progeria disorder, Werner Syndrome. In our previous publication, we connected the DNA damage sensor Werner's Helicase Interacting Protein (WHIP), a binding partner of WRN, to the NPC. Here, we confirm the association of the WRN/WHIP complex and NDC1. In established WRN/WHIP knockout cell lines, we further demonstrate the interdependence of WRN/WHIP and Nucleoporins (Nups). These changes do not completely abrogate the barrier of the Nuclear Envelope (NE) but do affect the distribution of FG Nups and the RAN gradient, which are necessary for nuclear transport. Evidence from WRN/WHIP knockout cell lines demonstrates changes in the processing and nucleolar localization of lamin B1. The appearance of "RAN holes" void of RAN corresponds to regions within the nucleolus filled with condensed pools of lamin B1. From WRN/WHIP knockout cell line extracts, we found three forms of lamin B1 that correspond to mature holoprotein and two potential post-translationally modified forms of the protein. Upon treatment with topoisomerase inhibitors lamin B1 cleavage occurs only in WRN/WHIP knockout cells. Our data suggest the link of the NDC1 and WRN as one facet of the network between the nuclear periphery and genome stability. Loss of WRN complex leads to multiple alterations at the NPC and the nucleolus. © 2013. Published by Elsevier B.V. All rights reserved.

Modeling of sediment transport along Mangalore coast using mike 21

Digital Repository Service at National Institute of Oceanography (India)

Babu, K.S.; Dwarakish, G.S.; Jayakumar, S.

in the coastal system. However, large gaps remain in our knowledge of sediment transport processes, and a continuing need exists for the development of reliable, well- validated, practical modeling systems. To this end the coastal processes ofManga10re Coast..., Thiruvananthapuram, India, Vol. 1,578-585. [3] Danish Hydraulic Institute (2000), "MIKE 21 User Guide and manual". [4] Davies A.G., Van Rijn L.e., Damgaard I.S., Van de Graff 1. and Ribberink I.S. (2002), "Intercomparison of Research and Practical Sand Transport...

Comments on Mike Rose's Essay "Rethinking Remedial Education and the Academic-Vocational Divide"

Science.gov (United States)

Goldrick-Rab, Sara

2012-01-01

The struggle over whether all students have a right to a high-quality, affordable college education, or whether it is a privilege they must "earn" through high test scores and parental savings for tuition, plays out daily in the so-called "remedial" or "developmental" classes. This article presents the author's comments on Mike Rose's essay…

Mike Davis, guérilla dans les sciences sociales.

Directory of Open Access Journals (Sweden)

Yveline Lévy-Piarroux

2009-03-01

Full Text Available « La plaine est morne et morte ― et la ville la mange. » Emile Verhaeren, « La plaine » in Les villes tentaculaires Le titre anglais de l’ouvrage de Mike Davis et Daniel B. Monk est Evil Paradises: Dreamworlds of Neoliberalism (2007. Les traducteurs ont conservé l’oxymore de la première formulation. Les « mondes de rêve » sont devenus « les villes hallucinées », allusion croisée à deux recueils de poésie d’Émile Verhaeren, Les campagnes hallucinées (1893 ...

Un'estrema solitudine la vita e l'opera di Werner Heisenberg

CERN Document Server

Cassidy, David C

1996-01-01

Il genio di Werner Heisenberg attraversa l'orizzonte della fisica del nostro secolo come una meteora. Testimoniano della fecondità e dell'originalità del suo pensiero non solo il Nobel che gli fu assegnato a soli 32 anni, ma soprattutto i decisivi impulsi da lui dati alla fisica quantistica, alla teoria delle particelle elementari, alla teoria del nucleo. Si deve a Heisenberg quel "principio di indeterminazione" che ha rivoluzionato non solo il corso della fisica ma il modo di concepire la posizione dell'uomo nell'universo. L'interesse del libro, però, vuole andare oltre la fisica, giacché il curriculum del "ragazzo di campagna dei biondi capelli" rispecchia in forma emblematica l'ambiguo rapporto della scienza col potere.

A rare cause of acute abdominal pain: Herlyn-Werner-Wunderlich syndrome.

Science.gov (United States)

Aydin, Ramazan; Ozdemir, Ayse Zehra; Ozturk, Bahadir; Bilgici, Meltem Ceyhan; Tosun, Migraci

2014-01-01

Herlyn-Werner-Wunderlich (HWW) syndrome is a rare müllerian duct anomaly with uterus didelphys, unilateral obstructed hemivagina, and ipsilateral renal agenesis. Patients with this syndrome generally present after menarche with pelvic pain and mass and, rarely, primary infertility in later years. Strong suspicion and knowledge of this syndrome are mandatory for an accurate diagnosis. A 14-year-old female patient presented with acute retention of urine and abdominopelvic pain. Her condition was diagnosed with the use ultrasonography and magnetic resonance imaging as a case of HWW syndrome. She was treated with vaginal hemiseptal resection. The HWW syndrome should be considered among the differential diagnoses in girls with renal anomalies presenting with pelvic mass, symptoms of acute abdominal pain, and acute urinary retention.

Sudden birth versus sudden death of entanglement for the extended Werner-like state in a dissipative environment

International Nuclear Information System (INIS)

Chuan-Jia, Shan; Tao, Chen; Ji-Bing, Liu; Wei-Wen, Cheng; Tang-Kun, Liu; Yan-Xia, Huang; Hong, Li

2010-01-01

In this paper, we investigate the dynamical behaviour of entanglement in terms of concurrence in a bipartite system subjected to an external magnetic field under the action of dissipative environments in the extended Werner-like initial state. The interesting phenomenon of entanglement sudden death as well as sudden birth appears during the evolution process. We analyse in detail the effect of the purity of the initial entangled state of two qubits via Heisenberg XY interaction on the apparition time of entanglement sudden death and entanglement sudden birth. Furthermore, the conditions on the conversion of entanglement sudden death and entanglement sudden birth can be generalized when the initial entangled state is not pure. In particular, a critical purity of the initial mixed entangled state exists, above which entanglement sudden birth vanishes while entanglement sudden death appears. It is also noticed that stable entanglement, which is independent of different initial states of the qubits (pure or mixed state), occurs even in the presence of decoherence. These results arising from the combination of the extended Werner-like initial state and dissipative environments suggest an approach to control and enhance the entanglement even after purity induced sudden birth, death and revival. (general)

Werner Sombart and his reception in Italy

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Simona Pisanelli

2015-03-01

Full Text Available This article intends to focus on the difficulty encountered by Werner Sombart’s works in gaining a hearing in various Italian intellectual circuits. As is well known, Sombart belonged to the German Historical School of economics, sharing with other scholars of that school the same problems in getting his work known in Italy. Our aim is to explain the reason for this hostile reception. First of all, we will analyze the factors which generally hindered the spread of the German Historical School in Italy, recognizing in economists like Francesco Ferrara, Idealists like Benedetto Croce and Marxists like Antonio Labriola some of its strongest opponents. We will dwell on the cases of Gustav Schmoller and Max Weber, in order to give two representative examples of the slow and complicated Italian reception of methodological approaches and analytical perspectives which characterized the scientific experience of the German Historical School. Secondly, we will try to show why Sombart was even less appreciated than other German social scientists, giving the reasons that attracted severe criticism from economists, economic historians and sociologists towards his interdisciplinary approach in the analysis of modern capitalism. Finally, we will show the reasons of the contemporary rediscovery of Sombart and of his works.

Intercomparison of the Dew-Point Temperature Realizations at LPM and MIKES in the Range from -70 °C to + 20 ° C

Science.gov (United States)

Heinonen, Martti; Zvizdic, Davor; Sestan, Danijel

2012-09-01

The first European humidity key comparison EURAMET-T.K6 was completed in 2008, and it covered the dew-point temperature range from -50 °C to + 20 °C. Both LPM and MIKES participated in the comparison, but a new low dew-point generator was introduced at LPM as a result of progress in the EUROMET P912 project. To extend the range of available comparison evidence down to -70 °C and to study the validity of improved uncertainties of LPM, a bilateral comparison was carried out between LPM and MIKES in 2009-2010. The applied comparison procedure was similar to that applied in EURAMET-T.K6. However, only one transfer standard was used instead of two units and the measurement point -70 °C was added in the measurement scheme. The results show that the bilateral equivalence between LPM and MIKES is between (0.00 ± 0.06) °C and (0.02 ± 0.08) °C in the range from -50 °C to + 20 °C and (0.01 ± 0.10) °C at -70 °C. Using MIKES results as the link to the EURAMET.T-K6, it is shown that the difference between the results obtained with the new LPM dew-point temperature standard and the EURAMET Comparison Reference Values is between (-0.02 ± 0.08) °C at 20 °C and (+ 0.02 ± 0.07) ° C at -50 °C.

Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome.

Science.gov (United States)

Bagley, Mark C; Davis, Terence; Rokicki, Michal J; Widdowson, Caroline S; Kipling, David

2010-02-01

UR-13756 is a potent and selective p38 mitogen-activated protein kinase (MAPK) inhibitor, reported to have good bioavailability and pharmacokinetic properties and, thus, is of potential use in the treatment of accelerated aging in Werner syndrome. Irradiation of 2-chloroacrylonitrile and methylhydrazine in ethanol at 100 °C gives 1-methyl-3-aminopyrazole, which reacts with 4-fluorobenzaldehyde and a ketone, obtained by Claisen condensation of 4-picoline, in a Hantzsch-type 3-component hereocyclocondensation, to give the pyrazolopyridine UR-13756. UR-13756 shows p38 MAPK inhibitory activity in human telomerase reverse transcriptase-immortalized HCA2 dermal fibroblasts, with an IC(50) of 80 nm, as shown by ELISA, is 100% efficacious for up to 24 h at 1.0 μm and displays excellent kinase selectivity over the related stress-activated c-Jun kinases. In addition, UR-13756 is an effective p38 inhibitor at 1.0 μm in Werner syndrome cells, as shown by immunoblot. The convergent synthesis of UR-13756 is realized using microwave dielectric heating and provides a highly selective inhibitor that shows excellent selectivity for p38 MAPK over c-Jun N-terminal kinase.

Design of the central region in the Gustaf Werner cyclotron at the Uppsala university

CERN Document Server

Toprek, D; Lundstrom, B; Wessman, D

2002-01-01

This paper describes the design of the central region in the Gustaf Werner cyclotron for h=1, 2 and 3 modes of acceleration. The electric field distribution in the inflector and in the four acceleration gaps has been numerically calculated from an electric potential map produced by the program RELAX3D. The geometry of the central region has been tested with the computations of orbits carried out by means of the computer code CYCLONE. The optical properties of the spiral inflector and the central region were studied by using the programs CASINO and CYCLONE, respectively.

Design of the central region in the Gustaf Werner cyclotron at the Uppsala university

International Nuclear Information System (INIS)

Toprek, Dragan; Reistad, Dag; Lundstrom, Bengt; Wessman, Dan

2002-01-01

This paper describes the design of the central region in the Gustaf Werner cyclotron for h=1, 2 and 3 modes of acceleration. The electric field distribution in the inflector and in the four acceleration gaps has been numerically calculated from an electric potential map produced by the program RELAX3D. The geometry of the central region has been tested with the computations of orbits carried out by means of the computer code CYCLONE. The optical properties of the spiral inflector and the central region were studied by using the programs CASINO and CYCLONE, respectively

Doing justice to the political: the International Criminal Court in Uganda and Sudan: a reply to Sarah Nouwen and Wouter Werner

NARCIS (Netherlands)

Schotel, B.

2011-01-01

This article is a reaction to Sarah Nouwen and Wouter Werner, ‘Doing Justice to the Political. The International Criminal Court in Uganda and Sudan’, 21 EJIL (2010) 941. It takes issue with attempts to understand international law and particularly the workings of the International Criminal Court in

Briti väliskomisjoni esimehe sõnul polnud neil Lissaboni leppe referendum vajalik / Mike Gapes ; intervjueerinud Evelyn Kaldoja

Index Scriptorium Estoniae

Gapes, Mike

2009-01-01

Briti alamkoja väliskomisjoni leiboristist juht Mike Gapes vastab küsimustele, mis puudutavad brittide võimalust hääletada Lissaboni leppe üle, Schengenist ja eurotsoonist välja jäämist ning lisasõdurite saatmist Afganistani

Integrated climate and hydrology modelling - Coupling of the HIRHAM regional climate model and the MIKE SHE hydrological model

Energy Technology Data Exchange (ETDEWEB)

Dahl Larsen, M.A. [Technical Univ. of Denmark. DTU Management Engineering, DTU Risoe Campus, Roskilde (Denmark)

2013-10-15

To ensure optimal management and sustainable strategies for water resources, infrastructures, food production and ecosystems there is a need for an improved understanding of feedback and interaction mechanisms between the atmosphere and the land surface. This is especially true in light of expected global warming and increased frequency of extreme events. The skill in developing projections of both the present and future climate depends essentially on the ability to numerically simulate the processes of atmospheric circulation, hydrology, energy and ecology. Previous modelling efforts of climate and hydrology have used each model component in an offline mode where the models are run in sequential steps and one model serves as a boundary condition or data input source to the other. Within recent years a new field of research has emerged where efforts have been made to dynamically couple existing climate and hydrology models to more directly include the interaction between the atmosphere and the land surface. The present PhD study is motivated by an ambition of developing and applying a modelling tool capable of including the interaction and feedback mechanisms between the atmosphere and the land surface. The modelling tool consists of a fully dynamic two-way coupling of the HIRHAM regional climate model and the MIKE SHE hydrological model. The expected gain is twofold. Firstly, HIRHAM utilizes the land surface component of the combined MIKE SHE/SWET hydrology and land surface model (LSM), which is superior to the LSM in HIRHAM. A wider range of processes are included at the land surface, subsurface flow is distributed in three dimensions and the temporal and spatial resolution is higher. Secondly, the feedback mechanisms of e.g. soil moisture and precipitation between the two models are included. The preparation of the HIRHAM and MIKE SHE models for the coupled study revealed several findings. The performance of HIRHAM was highly affected by the domain size, domain

On the probability distribution of stock returns in the Mike-Farmer model

Science.gov (United States)

Gu, G.-F.; Zhou, W.-X.

2009-02-01

Recently, Mike and Farmer have constructed a very powerful and realistic behavioral model to mimick the dynamic process of stock price formation based on the empirical regularities of order placement and cancelation in a purely order-driven market, which can successfully reproduce the whole distribution of returns, not only the well-known power-law tails, together with several other important stylized facts. There are three key ingredients in the Mike-Farmer (MF) model: the long memory of order signs characterized by the Hurst index Hs, the distribution of relative order prices x in reference to the same best price described by a Student distribution (or Tsallis’ q-Gaussian), and the dynamics of order cancelation. They showed that different values of the Hurst index Hs and the freedom degree αx of the Student distribution can always produce power-law tails in the return distribution fr(r) with different tail exponent αr. In this paper, we study the origin of the power-law tails of the return distribution fr(r) in the MF model, based on extensive simulations with different combinations of the left part L(x) for x 0 of fx(x). We find that power-law tails appear only when L(x) has a power-law tail, no matter R(x) has a power-law tail or not. In addition, we find that the distributions of returns in the MF model at different timescales can be well modeled by the Student distributions, whose tail exponents are close to the well-known cubic law and increase with the timescale.

Herlyn-Werner-Wunderlich Syndrome Consisting of Uterine Didelphys, Obstructed Hemivagina and Ipsilateral Renal Agenesis in a Newborn

Directory of Open Access Journals (Sweden)

Tsung-Hsin Wu

2012-02-01

Full Text Available Herlyn-Werner-Wunderlich (HWW syndrome is a rare variant of Müllerian duct anomalies consisting of uterine didelphys, obstructed hemivagina, and ipsilateral renal agenesis. Patients with HWW syndrome are usually asymptomatic until menarche, when they present with acute lower abdominal pain. Here we report a case of a female newborn with right renal agenesis diagnosed during the pregnancy. The patient presented with a protruding mass over the vaginal introitus that was associated with an obstructed hemivagina and uterine didelphys.

Hans Werner Richter - Wolfgang Borchert : zwei Schriftsteller im 2. Weltkrieg ; ihre Kriegseinsätze und die Umsetzung in Literatur

OpenAIRE

Brandes, Katrein

2018-01-01

Hans Werner Richter und Wolfgang Borchert, zwei der bekanntesten deutschen Nachkriegsschriftsteller, waren selbst auf erbittert umkämpften Schauplätzen des 2. Weltkrieges eingesetzt: Richter in Italien bei Cassino, Borchert an der Ostfront südlich Moskaus. Trotz der Auseinandersetzung mit ihren literarischen Zeugnissen aus dieser Zeit, wie Richters Roman „Die Geschlagenen“ und Borcherts Kurzgeschichten, ist die Frage nach ihrem eigenen Kriegserleben, nach Schuldbewusstsein und dem Niederschla...

A comparison of MIKE SHE and DRAINMOD for modeling forested wetland hydrology in coastal South Carolina, USA

Science.gov (United States)

Zhaohua Dai; Devendra M. Amatya; Ge Sun; Carl C. Trettin; Changsheng Li; Harbin Li

2010-01-01

Models are widely used to assess hydrologic impacts of land-management, land-use change and climate change. Two hydrologic models with different spatial scales, MIKE SHE (spatially distributed, watershed-scale) and DRAINMOD (lumped, fieldscale), were compared in terms of their performance in predicting stream flow and water table depth in a first-order forested...

Mike Ashley. Out of This World: Science Fiction, But Not As You Know It

OpenAIRE

Ransom, Amy J.

2013-01-01

The British Library held an exhibition on science fiction from 25 May to 25 September, 2011. Mike Ashley’s beautiful companion volume, Out of This World, offers a brilliant, illustrated history of science fiction. Destined for newcomers to the genre, the oversize tome provides a useful handbook and even some tidbits of lesser-known factoids for the specialist. I highly recommend this work for all libraries and coffee tables. Ashley has proven himself to be one of the genre’s foremost historia...

Rediscovery of Atelopus subornatus Werner, 1899 (Anura: Bufonidae), with a redescription of the tadpole.

Science.gov (United States)

Enciso-Calle, Maria Paula; Viuche-Lozano, Andres; Anganoy-Criollo, Marvin; Bernal, Manuel Hernando

2017-11-06

The Neotropical toads of the genus Atelopus are among the most imperiled of all amphibians (La Marca et al. 2005; Gonzalez-Maya et al. 2013; McCaffery et al. 2015). Nowadays, at least 90% of the 93 listed species are threatened and more than 77% are Critically Endangered (McCaffery et al. 2015; IUCN 2016). Colombia has 44 described species of Atelopus (Frost 2017), two of these are categorized as extinct (EX) by the IUCN (2016): A. ignescens and A. longirostris, although they were recently re-discovered in Ecuador (Tapia et al. 2017), 34 as critical endangered (CR), four as endangered (EN), two as vulnerable (VU), one species has data deficient (DD) and another one has not been evaluated. Atelopus subornatus Werner, 1899, is an endemic Colombian harlequin toad described from 2300 to 2800 m.a.s.l in the municipalities of Sibaté (Alto de Sibaté and Agua Bonita) and Fusagasuga (above Fusagasuga and Tierra Negra), in Cundinamarca (Fig. 1A), on the western flank from Cordillera Oriental of Colombia (Werner 1899; Lynch 1986; Lötters 1989, 1992). The last record of this species was in 1993 (Lötters 2005), and it currently is listed as Critically Endangered by the IUCN (2016). Herein, we report the rediscovery of A. subornatus at a new locality from Tolima, Colombia (Fig. 1A), and redescribe its tadpole. The determination of the species was based on comparisons with material deposited in the amphibian collection of the Instituto de Ciencias Naturales, Universidad Nacional de Colombia (ICN-UNAL) for all species of Atelopus reported from the same general area in Cundinamarca and relatively similar to A. subornatus. The specimens are housed in the Herpetological collection of the Tolima University (CZUT-A) and amphibian collection of ICN-UNAL.

Calibration of hydrodynamic model MIKE 11 for the sub-basin of the Piauitinga river, Sergipe, Brazil

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Marcos Vinicius Folegatti

2010-12-01

Full Text Available In Piauitinga river sub-basin the environment has been suffering from negative actions by humans such as deforestation around springs, inadequate use of the uptaken water, inappropriate use in domestic activities, siltation and sand exploitation, and contamination by domestic, industrial and agricultural residuals. The present study presents the one-dimensional hydrodynamic MIKE 11 model calibration that simulates the water flow in estuary, rivers, irrigation systems, channels and other water bodies. The aim of this work was to fit the MIKE 11 model to available discharge data for this sub-basin. Data from the period of 1994 to 1995 were used for calibration and data from 1996 to 2006 for validation, except the 1997 year, from which data were not available. Manning’s roughness coefficient was the main parameter used for the Piauitinga river sub-basin discharge calibration and other parameters were heat balance, water stratification and groundwater leakage. Results showed that the model had an excellent performance for the Piauitinga basin and had an efficiency coefficient of 0.9 for both periods. This demonstrates that this model can be used to estimate the water quantity in Piauitinga river sub-basin.

Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging

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Hoi-Hung Cheung

2014-04-01

Full Text Available Werner syndrome (WS patients exhibit premature aging predominantly in mesenchyme-derived tissues, but not in neural lineages, a consequence of telomere dysfunction and accelerated senescence. The cause of this lineage-specific aging remains unknown. Here, we document that reprogramming of WS fibroblasts to pluripotency elongated telomere length and prevented telomere dysfunction. To obtain mechanistic insight into the origin of tissue-specific aging, we differentiated iPSCs to mesenchymal stem cells (MSCs and neural stem/progenitor cells (NPCs. We observed recurrence of premature senescence associated with accelerated telomere attrition and defective synthesis of the lagging strand telomeres in MSCs, but not in NPCs. We postulate this “aging” discrepancy is regulated by telomerase. Expression of hTERT or p53 knockdown ameliorated the accelerated aging phenotypein MSC, whereas inhibition of telomerase sensitized NPCs to DNA damage. Our findings unveil a role for telomerase in the protection of accelerated aging in a specific lineage of stem cells.

Bernard Lerer: recipient of the 2014 inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine (Pacific Rim Association for Clinical Pharmacogenetics).

Science.gov (United States)

Ozdemir, Vural; Endrenyi, Laszlo; Aynacıoğlu, Sükrü; Bragazzi, Nicola Luigi; Dandara, Collet; Dove, Edward S; Ferguson, Lynnette R; Geraci, Christy Jo; Hafen, Ernst; Kesim, Belgin Eroğlu; Kolker, Eugene; Lee, Edmund J D; Llerena, Adrian; Nacak, Muradiye; Shimoda, Kazutaka; Someya, Toshiyuki; Srivastava, Sanjeeva; Tomlinson, Brian; Vayena, Effy; Warnich, Louise; Yaşar, Umit

2014-04-01

This article announces the recipient of the 2014 inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine by the Pacific Rim Association for Clinical Pharmacogenetics (PRACP): Bernard Lerer, professor of psychiatry and director of the Biological Psychiatry Laboratory, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. The Werner Kalow Responsible Innovation Prize is given to an exceptional interdisciplinary scholar who has made highly innovative and enduring contributions to global omics science and personalized medicine, with both vertical and horizontal (transdisciplinary) impacts. The prize is established in memory of a beloved colleague, mentor, and friend, the late Professor Werner Kalow, who cultivated the idea and practice of pharmacogenetics in modern therapeutics commencing in the 1950s. PRACP, the prize's sponsor, is one of the longest standing learned societies in the Asia-Pacific region, and was founded by Kalow and colleagues more than two decades ago in the then-emerging field of pharmacogenetics. In announcing this inaugural prize and its winner, we seek to highlight the works of prize winner, Professor Lerer. Additionally, we contextualize the significance of the prize by recalling the life and works of Professor Kalow and providing a brief socio-technical history of the rise of pharmacogenetics and personalized medicine as a veritable form of 21(st) century scientific practice. The article also fills a void in previous social science analyses of pharmacogenetics, by bringing to the fore the works of Kalow from 1995 to 2008, when he presciently noted the rise of yet another field of postgenomics inquiry--pharmacoepigenetics--that railed against genetic determinism and underscored the temporal and spatial plasticity of genetic components of drug response, with invention of the repeated drug administration (RDA) method that estimates the dynamic heritabilities of drug response. The prize goes a long way

Multi-site calibration, validation, and sensitivity analysis of the MIKE SHE Model for a large watershed in northern China

Science.gov (United States)

S. Wang; Z. Zhang; G. Sun; P. Strauss; J. Guo; Y. Tang; A. Yao

2012-01-01

Model calibration is essential for hydrologic modeling of large watersheds in a heterogeneous mountain environment. Little guidance is available for model calibration protocols for distributed models that aim at capturing the spatial variability of hydrologic processes. This study used the physically-based distributed hydrologic model, MIKE SHE, to contrast a lumped...

A Different Curriculum of Preparation for Work: Commentary on Mike Rose, Sara Goldrick-Rab, Kris Gutierrez and Norton Grubb

Science.gov (United States)

Worthen, Helena Harlow

2012-01-01

The January 2012 issue of "Mind, Culture, and Activity" published the Invited Presidential Address "Rethinking Remedial Education and the Academic-Vocational Divide," given by Mike Rose at the 2011 meeting of the American Educational Research Association in New Orleans, along with responses and commentary by Sara Goldrick-Rab, Kris Gutierrez, and…

[Werner Catel--a protagonist in Nazi "pediatric euthanasia" and his post-war career].

Science.gov (United States)

Petersen, Hans-Christian; Zankel, Sönke

2003-01-01

This article deals with the biography of Werner Catel, a German paediatrician and protagonist of the Nazi programme for "euthanasia of children". Based on original research into recently discovered source materials, two aspects of Catel's life are considered. Firstly, Catel's attitude towards "euthanasia" is analysed. This analysis is not limited to the period of National Socialism, but focuses also on the phase before 1933 and especially on the era after 1945. Secondly, the authors explore Catel's academic career. What effects on his career in the later Federal Republic of Germany had his exposed role in the Nazi programme for "euthanasia of children"? In this context it is also examined how the Christian-Albrechts-University of Kiel/Germany, which employed Catel until 1960 in a leading position, judged the work of its former professor after his death.

An unusual organ involvement in a case of Werner Syndrome: thyroid atrophy

Directory of Open Access Journals (Sweden)

Mustafa Altay

2015-06-01

Full Text Available Abstract: Werner Syndrome (WS is a premature aging disease that begins in adolescence or early adulthood and results in the appearance of old age by 30-40 years of age. Some endocrinological abnormalities were manifested in this rare disease, such as hypogonadism, diabetes mellitus, hyperlipidemia. In this article, we present a nineteen years-old female patient who had been diagnosed as WS two years ago because of type 2 diabetes mellitus, osteopenia, hyperlipidemia, cataract, gray hair, and skin atrophy. Subclinical hypothyroidism was detected at her laboratory tests. Thyroid ultrasonography (USG showed thyroid atrophy. Fine needle aspiration biopsy of both lobes confirmed this diagnose and excluded some infiltrative diseases such as amyloidosis. It should be kept in mind that thyroid atrophy could be seen in WS and, therefore, detailed thyroid examination including thyroid USG and close follow up should be performed in all patients with WS. [J Contemp Med 2015; 5(2.000: 144-146

"That was Heaven". Hadrian's Villa as "fabulous" Heaven in Angels in America by Mike Nichols

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Mauro Giori

2011-07-01

Full Text Available Angels in America is still Tony Kushner’s major achievement. In adapting it for television, Mike Nichols accurately respected the political agenda of the author (democratic, hebrew and homosexual, who also wrote the screenplay. The choice of Hadrian’s Villa (instead of a San Francisco devastated by the earthquake of 1906 as a background for the scenes which take place in the Paradise can be understood as coherent with Kushner’s ideological perspective, as well as with his original camp aesthetics.

The sinking of the Soviet Mike class nuclear powered submarine

International Nuclear Information System (INIS)

1989-01-01

The purpose of this preliminary study is to assess the quantities of the longer-lived or persistent radioactive materials, or source terms, that have been lost at sea with the sinking of the Soviet MIKE class submarine off Bear Island on 7 April 1989. The report arrives at an assessment of the amount of radioactivity and compares this to the quantities of radioactive materials dumped by the UK from 1953 to 1982 at which time sea dumping of radioactive wastes was suspended by international resolve. This comparison can be used to assess the relative significance of the sinking of this submarine. The study does not extrapolate the estimated radioactive source terms to an environmental or radiological significance of the sinking, although it is concluded that unless the submarine is recovered intact from the ocean floor, the by far greater part of the radioactive materials on board will disperse to the marine environment at some future time, if they are not doing so already. (author)

[The birth of acknowledgement: Michel Foucault and Werner Leibbrand].

Science.gov (United States)

Mildenberger, Florian

2006-01-01

In 1964, Werner Leibbrand (1896-1974) was the first German medical historian to present, in Sudhoffs Archiv, a review of the work of Michel Foucault (1926-1984). This paper examines some of the reasons leading to the fact that Leibbrand's own generation refused to acknowledge the importance of Foucault's ideas, while, later on, younger German medical historians, although impressed with Foucault's writings, failed to acknowledge, first, the close relationship between Leibbrand's and Foucault's world views, and, second, Leibbrand's attempts at introducing Foucault to German medical historians. Leibbrand with his Jewish wife had survived the Nazi period partly in hiding. His attempts at clearing post-war German psychiatry and medical historiography of NS-sympathizers isolated him among his colleagues, many of whom had begun their career during the Third Reich. Leibbrand enjoyed the support by the Swiss medical historian and avowed Communist Erwin Ackerknecht (1906-1988), but later turned against him, possibly because Acknerknecht had called Leibbrand's writings "unscientific". Leibbrand was unable to overcome his antagonisms with his contemporaries. At the same time, opposition to Ackerknecht made him appear a respresentative of the past in the eyes of the younger generation. Thus, when Foucault was accepted by the latter, they were not prepared to examine the work of Leibbrand and realize how close some of the ideas developed by Leibbrand and Foucault had been.

The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells.

Science.gov (United States)

Bagley, Mark C; Dwyer, Jessica E; Baashen, Mohammed; Dix, Matthew C; Murziani, Paola G S; Rokicki, Michal J; Kipling, David; Davis, Terence

2016-01-21

Microwave-assisted synthesis of the pyrazolyl ketone p38 MAPK inhibitor RO3201195 in 7 steps and 15% overall yield, and the comparison of its effect upon the proliferation of Werner Syndrome cells with a library of pyrazolyl ketones, strengthens the evidence that p38 MAPK inhibition plays a critical role in modulating premature cellular senescence in this progeroid syndrome and the reversal of accelerated ageing observed in vitro on treatment with SB203580.

Mike's Educational Program: Long Island, New York. Case Study. Social Relationships of Children and Adolescents with Deaf-Blindness Research Project.

Science.gov (United States)

Mar, Harvey H.; Sall, Nancy

This case study describes the educational history and current program of Mike, a mainstreamed sixth-grader with deaf-blindness. It addresses the boy's successes and the ongoing challenges faced by his family, his educational team, and his peers. Background information notes his diagnosis of total blindness and moderate to severe hearing loss, his…

Herlyn Werner Wunderlich Syndrome with Hematocolpos: An Unusual Case Report of Full Diagnostic Approach and Treatment

Directory of Open Access Journals (Sweden)

Rohit Bhoil

2016-05-01

Full Text Available Herlyn-Werner-Wunderlich (HWW syndrome is an uncommon combined müllerian duct anomalies (MDAs and mesonephric duct malformation of female urogenital tract characterized by uterus didelphys and obstructed hemi-vagina and ipsilateral renal agenesis (OHVIRA syndrome. We present a rare and unusual case of this syndrome in a 19 year-old female who suffered from hypomenorrhoea and abdominal pain. She had an obstructed hemi-vagina on right side which led to marked distention of ipsilateral cervix, while proximal hemi-vagina compressed the contralateral side causing its partial obstruction resulting in hypomenorrhoea. Understanding the imaging findings of this rare condition is important for early diagnosis in order to prevent complications which may lead to infertility.

Biochemical characterization of an exonuclease from Arabidopsis thaliana reveals similarities to the DNA exonuclease of the human Werner syndrome protein.

Science.gov (United States)

Plchova, Helena; Hartung, Frank; Puchta, Holger

2003-11-07

The human Werner syndrome protein (hWRN-p) possessing DNA helicase and exonuclease activities is essential for genome stability. Plants have no homologue of this bifunctional protein, but surprisingly the Arabidopsis genome contains a small open reading frame (ORF) (AtWRNexo) with homology to the exonuclease domain of hWRN-p. Expression of this ORF in Escherichia coli revealed an exonuclease activity for AtWRN-exo-p with similarities but also some significant differences to hWRN-p. The protein digests recessed strands of DNA duplexes in the 3' --> 5' direction but hardly single-stranded DNA or blunt-ended duplexes. In contrast to the Werner exonuclease, AtWRNexo-p is also able to digest 3'-protruding strands. DNA with recessed 3'-PO4 and 3'-OH termini is degraded to a similar extent. AtWRNexo-p hydrolyzes the 3'-recessed strand termini of duplexes containing mismatched bases. AtWRNexo-p needs the divalent cation Mg2+ for activity, which can be replaced by Mn2+. Apurinic sites, cholesterol adducts, and oxidative DNA damage (such as 8-oxoadenine and 8-oxoguanine) inhibit or block the enzyme. Other DNA modifications, including uracil, hypoxanthine and ethenoadenine, did not inhibit AtWRNexo-p. A mutation of a conserved residue within the exonuclease domain (E135A) completely abolished the exonucleolytic activity. Our results indicate that a type of WRN-like exonuclease activity seems to be a common feature of the DNA metabolism of animals and plants.

Hydrological and hydrogeological effects of an open repository in Forsmark. Final MIKE SHE flow modelling results for the Environmental Impact Assessment

International Nuclear Information System (INIS)

Maartensson, Erik; Gustafsson, Lars-Goeran

2010-07-01

This report presents methodology and modelling results concerning a deep-rock repository for spent nuclear fuel in Forsmark. Specifically, the modelling tools MIKE SHE, MIKE 11 and MOUSE are used to quantify the groundwater inflow to the repository and associated hydrological and hydrogeological effects during the construction and operation phases. The modelling results presented in the report provide input to the Environmental Impact Assessment (EIA) that will be part of a permit application according to the Environmental Code. Based on an existing MIKE SHE model for Forsmark, the first step of the modelling process was to implement an updated hydrogeological model of the bedrock and to increase the vertical and horizontal extents of the model domain. Other model updates involve the vegetation classification, and implementation of SFR (final repository for short-lived radioactive waste) and the subsurface drainage system at the nearby nuclear power plant. The updated model was calibrated using measured data on groundwater levels in the Quaternary deposits and the bedrock, water levels in lakes, and stream discharges. The calibrated model was then used for simulation of undisturbed conditions (i.e. without the repository) as a reference for modelling results obtained for disturbed conditions (with the repository). The modelling results for undisturbed conditions that are presented in the report closely resemble those of the final MIKE SHE site descriptive modelling (SDM-Site Forsmark). The repository layout was implemented as pipe links (segments) in the modelling tool MOUSE, and the implemented layout was used for the modelling of disturbed conditions. The study uses an updated and verified MIKE SHE-MOUSE coupling routine that is specifically adapted for calculation of groundwater inflow to grouted rock tunnels. The vertical shafts of the repository are implemented in the form of MIKE SHE grid cells with atmospheric pressure. Modelling results for disturbed

Hydrological and hydrogeological effects of an open repository in Forsmark. Final MIKE SHE flow modelling results for the Environmental Impact Assessment

Energy Technology Data Exchange (ETDEWEB)

Maartensson, Erik; Gustafsson, Lars-Goeran (DHI Sverige AB (Sweden))

2010-07-15

This report presents methodology and modelling results concerning a deep-rock repository for spent nuclear fuel in Forsmark. Specifically, the modelling tools MIKE SHE, MIKE 11 and MOUSE are used to quantify the groundwater inflow to the repository and associated hydrological and hydrogeological effects during the construction and operation phases. The modelling results presented in the report provide input to the Environmental Impact Assessment (EIA) that will be part of a permit application according to the Environmental Code. Based on an existing MIKE SHE model for Forsmark, the first step of the modelling process was to implement an updated hydrogeological model of the bedrock and to increase the vertical and horizontal extents of the model domain. Other model updates involve the vegetation classification, and implementation of SFR (final repository for short-lived radioactive waste) and the subsurface drainage system at the nearby nuclear power plant. The updated model was calibrated using measured data on groundwater levels in the Quaternary deposits and the bedrock, water levels in lakes, and stream discharges. The calibrated model was then used for simulation of undisturbed conditions (i.e. without the repository) as a reference for modelling results obtained for disturbed conditions (with the repository). The modelling results for undisturbed conditions that are presented in the report closely resemble those of the final MIKE SHE site descriptive modelling (SDM-Site Forsmark). The repository layout was implemented as pipe links (segments) in the modelling tool MOUSE, and the implemented layout was used for the modelling of disturbed conditions. The study uses an updated and verified MIKE SHE-MOUSE coupling routine that is specifically adapted for calculation of groundwater inflow to grouted rock tunnels. The vertical shafts of the repository are implemented in the form of MIKE SHE grid cells with atmospheric pressure. Modelling results for disturbed

Leg ulcer in Werner syndrome (adult progeria): a case report.

Science.gov (United States)

Fumo, Giuseppe; Pau, Monica; Patta, Federico; Aste, Nicola; Atzori, Laura

2013-03-15

Werner syndrome (WS; MIM#277700) or adult progeria, is a rare disease, associated with mutations of a single gene (RECQL2 or WRN), located on chromosome 8 (8p12). It codes a DNA-helicase, whose defects cause genomic instability. The highest incidences are reported in Japan and Sardinia (Italy). On this major island of the Mediterranean Basin, the WS cases have been observed in the northern areas. The authors describe the apparently first case reported in southern Sardinia, a 51-year-old woman, who was born in and resides in the province of Cagliari. She presented with a 9-year history of an intractable leg ulcer and other characteristic symptoms, including "bird-like" face, high-pitched voice, premature greying, short stature, abdominal obesity in contrast with thin body type, scleroderma-like legs, decreased muscle mass, diabetes, atherosclerosis, and premature menopause. A specialized genetic Institute of Research (IRCCS-IDI, Rome) confirmed the clinical diagnosis. There is no cure or specific treatment and patients must be periodically screened for an increased risk of cardiovascular and cerebrovascular disease and malignancies. Among the many findings, leg ulcers significantly affect the patient's quality of life. This problem may send the patient to the dermatologist, who finally suspects the diagnosis. Poor response to medical treatment may require aggressive repeated surgery, with poor or temporary results.

Numerical modelling of solute transport at Forsmark with MIKE SHE. Site descriptive modelling SDM-Site Forsmark

Energy Technology Data Exchange (ETDEWEB)

Gustafsson, Lars-Goeran; Sassner, Mona (DHI Sverige AB, Stockholm (Sweden)); Bosson, Emma (Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden))

2008-12-15

The Swedish Nuclear Fuel and Waste Management Company (SKB) is performing site investigations at two different locations in Sweden, referred to as the Forsmark and Laxemar areas, with the objective of siting a final repository for high-level radioactive waste. Data from the site investigations are used in a variety of modelling activities. This report presents model development and results of numerical transport modelling based on the numerical flow modelling of surface water and near-surface groundwater at the Forsmark site. The numerical modelling was performed using the modelling tool MIKE SHE and is based on the site data and conceptual model of the Forsmark areas. This report presents solute transport applications based on both particle tracking simulations and advection-dispersion calculations. The MIKE SHE model is the basis for the transport modelling presented in this report. Simulation cases relevant for the transport from a deep geological repository have been studied, but also the pattern of near surface recharge and discharge areas. When the main part of the modelling work presented in this report was carried out, the flow modelling of the Forsmark site was not finalised. Thus, the focus of this work is to describe the sensitivity to different transport parameters, and not to point out specific areas as discharge areas from a future repository (this is to be done later, within the framework of the safety assessment). In the last chapter, however, results based on simulations with the re-calibrated MIKE SHE flow model are presented. The results from the MIKE SHE water movement calculations were used by cycling the calculated transient flow field for a selected one-year period as many times as needed to achieve the desired simulation period. The solute source was located either in the bedrock or on top of the model. In total, 15 different transport simulation cases were studied. Five of the simulations were particle tracking simulations, whereas the rest

History and the "imagination of men's hearts" in Mike Nicol's Horseman

Directory of Open Access Journals (Sweden)

Ian-Malcolm Rijsdijk

2011-10-01

Full Text Available http://dx.doi.org/10.5007/2175-8026.2011n61p109 In light of the scattered nature of criticism regarding the work of South African author, Mike Nicol, this article surveys the transformation of Nicol’s novelistic style so as to better lluminate the representation and deployment of history in his third novel, Horseman (1994. South Africa’s political transformation not only offers a context for understanding the novel, but also provokes questions for the South African writer: how does the writer respond to the oppression of apartheid and the possibility of a new dispensation given the memory of such oppression? What forms best articulate that response? In the case of Horseman, how does one read the book’s pessimism against the backdrop of the first democratic elections? A consideration of Nicol’s greater body of work–his realist and more allegorical modes–points to a complicated relationship between the South African writer and the period of transition leading up to the 1994 elections.

model Application Mike Basin in the management of dam water Lakhmess (Siliana)

International Nuclear Information System (INIS)

Saoudi, Ahmed

2016-01-01

The objective of this work is to study the water management of the lakhmess Siliana in order to evaluate the water reserve in the da to the years 2034 and imagine a scenario water consumption doubling of the dam, following the creation of a new irrigation scheme. Mike Basin software IHD series of the 2003 version was applied for hydrological simulation of the amount of water in the study area, a series of three measurement years (2007 to 2010) inventories and monthly contributions was used for the calibration of model. The validation of the results was performed on a series of three years (2010-2013) by statistical analysis of the residual series (observed values - calculated values). The volume of water stored simulated, could meet the water demand until 2034 years, since it is equivalent the amount of water necessary for the preservation of the status of the dam but the dam will go through critical period where the obligation to apply a correction for mitigating leaks.

Bernard Lerer: Recipient of the 2014 Inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine (Pacific Rim Association for Clinical Pharmacogenetics)

Science.gov (United States)

Aynacıoğlu, Şükrü; Bragazzi, Nicola Luigi; Dandara, Collet; Dove, Edward S.; Ferguson, Lynnette R.; Geraci, Christy Jo; Hafen, Ernst; Kesim, Belgin Eroğlu; Kolker, Eugene; Lee, Edmund J.D.; LLerena, Adrian; Nacak, Muradiye; Shimoda, Kazutaka; Someya, Toshiyuki; Srivastava, Sanjeeva; Tomlinson, Brian; Vayena, Effy; Warnich, Louise; Yaşar, Ümit

2014-01-01

Abstract This article announces the recipient of the 2014 inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine by the Pacific Rim Association for Clinical Pharmacogenetics (PRACP): Bernard Lerer, professor of psychiatry and director of the Biological Psychiatry Laboratory, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. The Werner Kalow Responsible Innovation Prize is given to an exceptional interdisciplinary scholar who has made highly innovative and enduring contributions to global omics science and personalized medicine, with both vertical and horizontal (transdisciplinary) impacts. The prize is established in memory of a beloved colleague, mentor, and friend, the late Professor Werner Kalow, who cultivated the idea and practice of pharmacogenetics in modern therapeutics commencing in the 1950s. PRACP, the prize's sponsor, is one of the longest standing learned societies in the Asia-Pacific region, and was founded by Kalow and colleagues more than two decades ago in the then-emerging field of pharmacogenetics. In announcing this inaugural prize and its winner, we seek to highlight the works of prize winner, Professor Lerer. Additionally, we contextualize the significance of the prize by recalling the life and works of Professor Kalow and providing a brief socio-technical history of the rise of pharmacogenetics and personalized medicine as a veritable form of 21st century scientific practice. The article also fills a void in previous social science analyses of pharmacogenetics, by bringing to the fore the works of Kalow from 1995 to 2008, when he presciently noted the rise of yet another field of postgenomics inquiry—pharmacoepigenetics—that railed against genetic determinism and underscored the temporal and spatial plasticity of genetic components of drug response, with invention of the repeated drug administration (RDA) method that estimates the dynamic heritabilities of drug response. The prize goes a

Herlyn-werner-wunderlich syndrome: MRI findings, radiological guide (two cases and literature review), and differential diagnosis

International Nuclear Information System (INIS)

Del Vescovo, Riccardo; Battisti, Sofia; Di Paola, Valerio; Piccolo, Claudia L; Cazzato, Roberto L; Sansoni, Ilaria; Grasso, Rosario F; Zobel, Bruno Beomonte

2012-01-01

Herlyn-Werner-Wunderlich (HWW) syndrome is a very rare congenital anomaly of the urogenital tract involving Müllerian ducts and Wolffian structures, and it is characterized by the triad of didelphys uterus, obstructed hemivagina and ipsilateral renal agenesis. It generally occurs at puberty and exhibits non-specific and variable symptoms with acute or pelvic pain shortly following menarche, causing a delay in the diagnosis. Moreover, the diagnosis is complicated by the infrequency of this syndrome, because Müllerian duct anomalies (MDA) are infrequently encountered in a routine clinical setting. two cases of HWW syndrome in adolescents and a differential diagnosis for one case of a different MDA, and the impact of magnetic resonance (MR) imaging technology to achieve the correct diagnosis. MR imaging is a very suitable diagnostic tool in order to perform the correct diagnosis of HWW syndrome

IAEA fifty years: more than just safeguards. Interview with Professor Werner Burkart

International Nuclear Information System (INIS)

Anon.

2007-01-01

Professor Werner Burkart, IAEA Deputy Director General and head of the Nuclear Sciences and Applications Division, comments upon matters associated with the fiftieth anniversary of the International Atomic Energy Agency (IAEA). The Agency was founded on July 29, 1957. Today it is a worldwide organization of the United Nations with 144 member countries and manifold duties in the field of nuclear power utilization. The mandate of IAEA is based on the 'Atoms for Peace' initiative, its essence being support of all member countries in the use of nuclear power as long as IAEA safeguards on the spot ensure that no military aims are pursued in those activities. The safeguards work serves to prevent military uses. IAEA recommendations for a global nuclear safety culture, the so-called Safety Standards, are employed by member countries as a basis of legislation and ordinances. The emerging renaissance of nuclear power will be accompanied by the IAEA especially with regard to the important aspects of harmonization, safeguards, safety, security, and readiness for emergencies. The interview took place in Vienna on September 20, 2007. The questions were asked by the President of the Swiss Nuclear Forum, Dr. Bruno Pellaud, former Deputy Director General of IAEA. (orig.)

Delayed diagnosis of Herlyn-Werner-Wunderlich syndrome due to microperforation and pyocolpos in obstructed vaginal canal.

Science.gov (United States)

Wozniakowska, Ewa; Torres, Anna; Milart, Pawel; Wozniak, Slawomir; Czuczwar, Piotr; Szkodziak, Piotr; Paszkowski, Tomasz

2014-08-01

To present a rare anomaly consisting of uterus didelphys, longitudinal vaginal septum, obstructed hemivagina with pyocolpos, fistula to the open vaginal canal, and ipsilateral renal agenesis, referred as Herlyn-Werner-Wunderlich syndrome (HWWS). A 14-year-old girl with recurring purulent vaginal discharge lasting for a few months. Preoperative examination revealed one vaginal canal with one cervical opening on the right side. There was a fistula leading from the obstructed vaginal canal to the left vagina. Intravaginal ultrasound examination demonstrated a longitudinal vaginal septum and a closed pyocolpos on the right side. The longitudinal vaginal septum was excised by way of electrocauterization under direct vision. HWWS should be considered in the differential diagnosis in patients with uterus didelphys and unusual symptoms such as pyocolpos and vaginal discharge. Copyright © 2014 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

Numerical modelling of solute transport at Forsmark with MIKE SHE. Site descriptive modelling SDM-Site Forsmark

International Nuclear Information System (INIS)

Gustafsson, Lars-Goeran; Sassner, Mona; Bosson, Emma

2008-12-01

The Swedish Nuclear Fuel and Waste Management Company (SKB) is performing site investigations at two different locations in Sweden, referred to as the Forsmark and Laxemar areas, with the objective of siting a final repository for high-level radioactive waste. Data from the site investigations are used in a variety of modelling activities. This report presents model development and results of numerical transport modelling based on the numerical flow modelling of surface water and near-surface groundwater at the Forsmark site. The numerical modelling was performed using the modelling tool MIKE SHE and is based on the site data and conceptual model of the Forsmark areas. This report presents solute transport applications based on both particle tracking simulations and advection-dispersion calculations. The MIKE SHE model is the basis for the transport modelling presented in this report. Simulation cases relevant for the transport from a deep geological repository have been studied, but also the pattern of near surface recharge and discharge areas. When the main part of the modelling work presented in this report was carried out, the flow modelling of the Forsmark site was not finalised. Thus, the focus of this work is to describe the sensitivity to different transport parameters, and not to point out specific areas as discharge areas from a future repository (this is to be done later, within the framework of the safety assessment). In the last chapter, however, results based on simulations with the re-calibrated MIKE SHE flow model are presented. The results from the MIKE SHE water movement calculations were used by cycling the calculated transient flow field for a selected one-year period as many times as needed to achieve the desired simulation period. The solute source was located either in the bedrock or on top of the model. In total, 15 different transport simulation cases were studied. Five of the simulations were particle tracking simulations, whereas the rest

[Matthias Asche, Werner Buchholz, Anton Schindling. Die baltischen Lande im Zeitalter der Reformation und Konfessionalisierung : Livland, Estland, Ösel, Ingermanland, Kurland und Lettgallen; Stadt, Land und Konfession 1500-1721. T. 1-3] / Axel von C

Index Scriptorium Estoniae

Campenhausen, Axel von

2015-01-01

Arvustus: Asche, Matthias, Bucholz, Werner, Achindling, Anton. (Hrsg.) Die baltischen Lande im Zeitalter der Reformation und Konfessionalisierung : Livland, Estland, Ösel, Ingermanland, Kurland und Lettgallen; Stadt, Land und Konfession 1500-1721. T. 1-3. Münster: Aschendorff Verlag 2009, 2010, 2011

Muusikamaailm : Hans Werner Henze sünnipäevaks. "Nibelungide sõrmus" ka Dresdenis. Simon Rattle juhatas Beethovenit. Uued teosed Elliott Carterilt. Echo Klassik 2001 / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2001-01-01

Hans Werner Henze 75 sünnipäevapidustustest Saksamaal. R. Wagneri "Nibelungide sõrmus" lavastus Dresdenis. Berliini Filharmoonikute peadirigent Simon Rattle toob Berliini pidunädalate lõppmänguna Berliini Filharmooniasse mahuka Beethoveni tsükli. Detsembris 93 aastaseks saav USA helilooja Elliott Carter kirjutab ikka uusi tellimusteoseid ning tuleb ka ise esiettekandele. Deutsche Phono-Akademie andis Baden-Badenis kätte oma mainekad aasta-auhinnad Echo Klassik

Parkinson's disease and the quest for preclinical diagnosis: an interview with Professor Werner Poewe.

Science.gov (United States)

Poewe, Werner

2017-10-01

Werner Poewe speaks to Laura Dormer, Editorial Director: Professor Werner Poewe is Professor of Neurology and Director of the Department of Neurology at Innsbruck Medical University in Innsbruck, Austria. He held a Residency in Clinical Neurology and Psychiatry at the University of Innsbruck, Austria, from 1977 to 1984. From 1984 to 1985 he teamed up with Gerald Stern and Andrew Lees as a British Council Research Fellow at University College and Middlesex Hospital's Medical School in London to perform clinical studies into levodopa-induced dystonia and pharmacokinetics of levodopa in naive versus L-Dopa treated Parkinson's disease. Following his return to Austria, he held a position as Senior Lecturer in the Department of Neurology at the University of Innsbruck (1986-1989) after which he took over as Professor of Neurology and Acting Director of the Department of Neurology at Virchow Hospital of the Free University of Berlin (1990-1994). Professor Poewe's main research interests in the field of movement disorders are focused on differential and early diagnosis of Parkinson's disease, its natural history and pharmacological treatment. He has been involved in the steering committees of numerous drug trials in different stages of Parkinson's disease for the past 20 years and has authored and coauthored more than 500 original articles and reviews in the field of movement disorders. Professor Poewe served as President of the Austrian Society of Neurology from 2002 to 2004 as well as President of the Austrian Parkinson's Disease Society from 1996 to 2009. He has been awarded honorary membership of the German Society of Neurology as well as the Japanese Society of Neurology. His awards include the Walther-Birkmayer-Prize of the Austrian PD Society, the Dingebauer-Prize of the German Neurological Society as well as the Research Excellence Award of Innsbruck Medical University. Professor Poewe served as President of the International Movement Disorder Society (MDS) from

[Die baltischen Lande im Zeitalter der Reformation und Konfessionalisierung : Livland, Estland, Ösel, Ingermanland, Kurland und Lettgallen : Stadt, Land und Konfession 1500-1721. Teil 4. Hrsg. von Matthias Asche, Werner Buchholtz und Anton Schindlin

Index Scriptorium Estoniae

Maasing, Madis, 1984-

2013-01-01

Arvustus: Die baltischen Lande im Zeitalter der Reformation und Konfessionalisierung : Livland, Estland, Ösel, Ingermanland, Kurland und Lettgallen : Stadt, Land und Konfession 1500-1721. Teil 4. (Katholisches Leben und Kirchenreform im Zeitalter der Glaubensspaltung, 72). Hrsg. von Matthias Asche, Werner Buchholtz und Anton Schindling. Verlag Aschendorff. Münster 2012

Simulation of the water balance of boreal watersheds of northeastern British Columbia, Canada using MIKE SHE, an integrated hydrological model

Science.gov (United States)

Abadzadesahraei, S.; Déry, S.; Rex, J. F.

2016-12-01

Northeastern British Columbia (BC) is undergoing rapid development for oil and gas extraction, largely depending on subsurface hydraulic fracturing (fracking), which relies on available freshwater. Even though this industrial activity has made substantial contributions to regional and provincial economies, it is important to ensure that sufficient and sustainable water supplies are available for all those dependent on the resource, including ecological systems. Further, BC statistics predict that the northeastern region's population will increase by 30% over the next 25 years, thereby amplifying the demands of domestic and industrial water usage. Hence, given the increasing demands for surface water in the complex wetlands of northeastern BC, obtaining accurate long-term water balance information is of vital importance. Thus, this study aims to simulate the 1979-2014 water balance at two boreal watersheds using the MIKE SHE model. More specifically, this research intends to quantify the historical, and regional, water budgets and their associated hydrological processes at two boreal watersheds—the Coles Lake and Tsea Lake watersheds—in northeastern BC. The development of coupled groundwater and surface water model of these watersheds are discussed. The model setup, calibration process, and results are presented, focusing on the water balance of boreal watersheds. Hydrological components within these watersheds are quantified through a combination of intensive fieldwork, observational data, analysis and numerical modeling. The output from the model provides important information for decision makers to manage water resources in northeastern BC. Keywords: Northeastern BC; boreal watershed; water balance; MIKE SHE hydrological model.

Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors

Directory of Open Access Journals (Sweden)

Davis Terence

2011-12-01

Full Text Available Abstract Fibroblasts derived from the progeroid Werner syndrome show reduced replicative lifespan and a "stressed" morphology, both alleviated using the MAP kinase inhibitor SB203580. However, interpretation of these data is problematical because although SB203580 has the stress-activated kinases p38 and JNK1/2 as its preferred targets, it does show relatively low overall kinase selectivity. Several lines of data support a role for both p38 and JNK1/2 activation in the control of cellular proliferation and also the pathology of diseases of ageing, including type II diabetes, diseases to which Werner Syndrome individuals are prone, thus making the use of JNK inhibitors attractive as possible therapeutics. We have thus tested the effects of the widely used JNK inhibitor SP600125 on the proliferation and morphology of WS cells. In addition we synthesised and tested two recently described aminopyridine based inhibitors. SP600125 treatment resulted in the cessation of proliferation of WS cells and resulted in a senescent-like cellular phenotype that does not appear to be related to the inhibition of JNK1/2. In contrast, use of the more selective aminopyridine CMPD 6o at concentrations that fully inhibit JNK1/2 had a positive effect on cellular proliferation of immortalised WS cells, but no effect on the replicative lifespan of primary WS fibroblasts. In addition, CMPD 6o corrected the stressed WS cellular morphology. The aminopyridine CMPD 6r, however, had little effect on WS cells. CMDP 6o was also found to be a weak inhibitor of MK2, which may partially explain its effects on WS cells, since MK2 is known to be involved in regulating cellular morphology via HSP27 phosphorylation, and is thought to play a role in cell cycle arrest. These data suggest that total JNK1/2 activity does not play a substantial role in the proliferation control in WS cells.

Thermal entanglement and teleportation of a thermally mixed entangled state of a Heisenberg chain through a Werner state

Institute of Scientific and Technical Information of China (English)

Huang Li-Yuan; Fang Mao-Fa

2008-01-01

The thermal entanglement and teleportation of a thermally mixed entangled state of a two-qubit Heisenberg XXX chain under the Dzyaloshinski-Moriya (DM) anisotropic antisymmetric interaction through a noisy quantum channel given by a Werner state is investigated. The dependences of the thermal entanglement of the teleported state on the DM coupling constant, the temperature and the entanglement of the noisy quantum channel are studied in detail for both the ferromagnetic and the antiferromagnetic cases. The result shows that a minimum entanglement of the noisy quantum channel must be provided in order to realize the entanglement teleportation. The values of fidelity of the teleported state are also studied for these two cases. It is found that under certain conditions, we can transfer an initial state with a better fidelity than that for any classical communication protocol.

Studi Model Distribusi Pencemaran di Pantai Utara Jawa Tengah Menggunakan Model MIKE 21 ECOLab

Directory of Open Access Journals (Sweden)

Adam Rus Nugroho

2016-06-01

Full Text Available Central Java has several estuaries which highly populated in their area, generating high load of waste water discharge. Research conducted on two of the estuaries, Comal estuary in Pemalang and Garang estuary in Semarang. Waste water discharge from population around upstream river of Comal and Garang pollute both estuaries, which are in north coast of Central Java. The aim of this research is to determine the amount of pollutants which enter the estuary and become sediment in Comal and Garang river estuary. The amount of pollution has been analyzed by QUAL2Kw program which then the result would be input data for sediment analysis using MIKE 21 ECOLab program. The result of research state that Comal estuary has BOD concentration of 4.26 mg/L on west season and 4.21 mg/L on east season. While Garang estuary has BOD concentration of 18.21 mg/L on west season and 4.73 mg/L on east season.

Niagara pumping generation station inundation mapping and consequence analysis with ArcGIS and Mike 21

Energy Technology Data Exchange (ETDEWEB)

Grover, Patrick; Khayer, Yasmin; Naumov, Aleksey [4DM Inc., Toronto, (Canada); Zhang, Yibing [Ontario Power Generation, Toronto, (Canada)

2010-07-01

Inundation mapping is a key factor of Ontario Power Generation's dam safety program. It is the basis for determining the hazard potential classification of the dam by modelling the consequences of a hypothetical dam failure. This paper presented the project for updating the inundation mapping and consequence analysis study at the Niagara Pump generating station (PGS) reservoir. A complete hydrotechnical assessment of the Niagara PGS reservoir was conducted. The modelling of various breach scenarios was carried out using the 2-D hydrodynamic software MIKE 21 in order to provide the hydraulic data necessary for producing the inundation maps. Updated EPRP maps were produced and a consequence analysis was performed which confirmed the existing hazard classification. The ArcGIS system was used as the underlying framework for all major components of the project. It was found that the use of GIS technologies improve the efficiency of both modelling and analysis.

Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells

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Mark C. Bagley

2015-06-01

Full Text Available Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2 inhibitors to study accelerated aging in Werner syndrome (WS cells, including the cross-coupling of a 2-chloroquinoline with a 3-pyridinylboronic acid, the coupling of an aryl bromide with an indolylboronic acid and the reaction of a 3-amino-4-bromopyrazole with 4-carbamoylphenylboronic acid. In all of these processes, the Suzuki-Miyaura reaction was fast and relatively efficient using a palladium catalyst under microwave irradiation. The process was incorporated into a rapid 3-step microwave-assisted method for the synthesis of a MK2 inhibitor involving 3-aminopyrazole formation, pyrazole C-4 bromination using N-bromosuccinimide (NBS, and Suzuki-Miyaura cross-coupling of the pyrazolyl bromide with 4-carbamoylphenylboronic acid to give the target 4-arylpyrazole in 35% overall yield, suitable for study in WS cells.

Introduction of a normal human chromosome 8 corrects abnormal phenotypes of Werner syndrome cells immortalized by expressing an hTERT gene

International Nuclear Information System (INIS)

Ariyoshi, Kentaro; Kodama, Seiji; Suzuki, Keiji; Goto, Makoto; Oshimura, Mitsuo; Ishizaki, Kanji; Watanabe, Masami

2009-01-01

Werner syndrome (WS) is an autosomal recessive disease characterized by premature aging and caused by mutations of the WRN gene mapped at 8p12. To examine functional complementation of WS phenotypes, we introduced a normal human chromosome 8 into a strain of WS fibroblasts (WS3RGB) immortalized by expressing a human telomerase reverse transcriptase subunit (hTERT) gene. Here, we demonstrate that the abnormal WS phenotypes including cellular sensitivities to 4-nitroquinoline-1-oxide (4NQO) and hydroxy urea (HU), and chromosomal radiosensitivity at G 2 phase are corrected by expression of the WRN gene mediated by introducing a chromosome 8. This indicates that those multiple abnormal WS phenotypes are derived from a primary, but not secondary, defect in the WRN gene. (author)

Participants in the “Schweizer Jugendforscht’” projects at CERN under the supervision of Günther Dissertori, professor at the Swiss Federal Institute of Technology (ETH Zürich) and other members of ETH Zürich, Werner Lustermann and Michael Dittmar.

CERN Multimedia

2005-01-01

Participants in the “Schweizer Jugendforscht’” projects at CERN under the supervision of Günther Dissertori, professor at the Swiss Federal Institute of Technology (ETH Zürich) and other members of ETH Zürich, Werner Lustermann and Michael Dittmar.

Untitled

Indian Academy of Sciences (India)

Frein, M. L., and Fisher, C. H. ... Ind. and Eng. Chen, 1948, 40, 534. 2. Kosolapoff, G. M. ... J. Amer. Chem. Soc., 1947, 69, 1651. 3. Fornet, R, ... Seifensieder-2tg., 1938, 65, 658 and 687. 4. Dusart, L, and Bardy, Ch. ... Compt, rend, 73, 1276. 5. Gal, H., and Etard, A. ... Ibid., 82, 457. 6. Demole, E. ... Deut. Chem. Ges, Ber, 1877 ...

Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.

Science.gov (United States)

Zhang, Weiqi; Li, Jingyi; Suzuki, Keiichiro; Qu, Jing; Wang, Ping; Zhou, Junzhi; Liu, Xiaomeng; Ren, Ruotong; Xu, Xiuling; Ocampo, Alejandro; Yuan, Tingting; Yang, Jiping; Li, Ying; Shi, Liang; Guan, Dee; Pan, Huize; Duan, Shunlei; Ding, Zhichao; Li, Mo; Yi, Fei; Bai, Ruijun; Wang, Yayu; Chen, Chang; Yang, Fuquan; Li, Xiaoyu; Wang, Zimei; Aizawa, Emi; Goebl, April; Soligalla, Rupa Devi; Reddy, Pradeep; Esteban, Concepcion Rodriguez; Tang, Fuchou; Liu, Guang-Hui; Belmonte, Juan Carlos Izpisua

2015-06-05

Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency. Here, we report on the generation of a human WS model in human embryonic stem cells (ESCs). Differentiation of WRN-null ESCs to mesenchymal stem cells (MSCs) recapitulates features of premature cellular aging, a global loss of H3K9me3, and changes in heterochromatin architecture. We show that WRN associates with heterochromatin proteins SUV39H1 and HP1α and nuclear lamina-heterochromatin anchoring protein LAP2β. Targeted knock-in of catalytically inactive SUV39H1 in wild-type MSCs recapitulates accelerated cellular senescence, resembling WRN-deficient MSCs. Moreover, decrease in WRN and heterochromatin marks are detected in MSCs from older individuals. Our observations uncover a role for WRN in maintaining heterochromatin stability and highlight heterochromatin disorganization as a potential determinant of human aging. Copyright © 2015, American Association for the Advancement of Science.

The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome

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Davis Terence

2013-01-01

Full Text Available Abstract Fibroblasts derived from the progeroid Werner syndrome (WS show reduced replicative lifespan and a “stressed” morphology, both phenotypes being alleviated by using the p38 MAP kinase inhibitor SB203580. Because p38 is a major hub for the control of stress-signalling pathways we were interested in examining the possible role for downstream kinases in order to refine our understanding of the role of p38 signalling in regulation of WS cell growth. To this end we treated WS and normal fibroblasts with MK2 inhibitors to determine whether MK2 inhibition would affect either the growth or morphology of WS cells. The first inhibitor, 7,8-dihydroxy-2,4-diamino-3-cyanobenzopyranopyridine (inhibitor 2, resulted in inhibition of WS cell growth and had no effect on morphology, effects that occurred below the level needed to inhibit MK2 and thus suggestive of inhibitor toxicity. The second inhibitor, 2-(2-quinolin-3-ylpyridin-4-yl-1,5,6,7-tetrahydro-4H-pyrrolo-[3,2-c]pyridin-4-one (CMPD16, resulted in a significant extension of WS fibroblast replicative capacity compared to normal cells. In addition, CMPD16 reverted the WS cellular morphology to that seen in normal dermal fibroblasts. These data suggest that MK2 activity plays a substantial role in proliferation control in WS cells. CMPD16 was not as effective in cellular lifespan extension as SB203580, however, suggesting that, although MK2 is a downstream kinase involved in cell cycle arrest, other p38 targets may play a role. Alternatively, as CMPD16 is toxic to cell growth at levels just above those that extend lifespan, it is possible that the therapeutic window is too small. However, as CMPD16 does show significant effects in WS fibroblasts, this acts as proof-of-principle for the efforts to design and synthesise improved MK2 inhibitors. As MK2 is involved in inflammatory processes and inflammation plays a major role in WS phenotypes, these data suggest MK2 as a potential therapeutic target

Recent Trends in WRN Gene Mutation Patterns in Individuals with Werner Syndrome.

Science.gov (United States)

Yamaga, Masaya; Takemoto, Minoru; Takada-Watanabe, Aki; Koizumi, Naoko; Kitamoto, Takumi; Sakamoto, Kenichi; Ishikawa, Takahiro; Koshizaka, Masaya; Maezawa, Yoshiro; Yokote, Koutaro

2017-08-01

To determine recent trends in mutation patterns in the WRN gene, which cause Werner syndrome (WS), a rare, inheritable progeroid syndrome in Japan. Retrospective cohort. Longitudinal survey of WS and literature search for case reports. Individuals whose genetic testing their facilities had requested between 2009 and October 2016 (N = 67). A nationwide epidemiological study was conducted from 2009 to 2011 to improve understanding of the pathology of WS and develop therapeutic guidelines. Since 2009, Chiba University Hospital consecutively evaluated the WRN gene in 67 individuals throughout Japan who had requested genetic testing. A literature search was also conducted for case reports on Japanese WS reported since 1997. A definitive diagnosis of WS was confirmed genetically in 50 of 67 participants. Through the literature search, 16 individuals diagnosed genetically with WS were identified. Of these 66 individuals with WS, 42 were homozygous for a WRN mutation, and 21 were compound heterozygotes. One novel mutant allele was identified in an individual with the compound heterozygous genotype. The proportion of compound heterozygotes (31.8%) was significantly greater than reported previously (14.2%), indicating that the incidence of consanguineous marriage of parents has decreased. The increased frequency of individuals with WS with the compound heterozygous genotype is a recent trend in Japan. A long-term follow-up study on WRN homozygotes and compound heterozygotes will allow the relationship between WRN genotype and clinical severity of WS to be evaluated in the future. © 2017, Copyright the Authors Journal compilation © 2017, The American Geriatrics Society.

Estimation of Ravine Sediment production using MIKE 11 model, in the lower Le Sueur Watershed, Minnesota

Science.gov (United States)

Azmera, L. A.; Miralles-Wilhelm, F. R.; Melesse, A. M.; Belmont, P.; Jennings, C. E.; Thomas, A.; Khalif, F.

2008-12-01

A study of sediment dynamics in the Le Sueur River basin, southern Minnesota has been initiated with the goal of developing an integrated sediment budget. Preliminary analysis of the sediment load to the Minnesota River has shown that the Le Sueur River contributes substantial amount of the sediment transport and deposition. Many deeply incised ravines exist, especially towards the lower Le Sueur River. The ravines are believed to be one of the major sediment producing sources in the river basin. Hence the ravine sediment production should be accounted for in the sediment budget. This study concentrates on the hydrology of the ravines and evaluates the sediment budget at the ravine scale. Field observations from summer 2008 show that most of the bluffs along the main stem of both ravines are actively eroding. Also, landsliding of the steep ravine valley walls and rapid incision of the fluvial channels within the ravine are producing sediment. Several large fill terraces are present along the main stem, towards the mouth of the ravines. Recent incision through these extensive fill terraces may be another sediment producing source. Sediment storage in the ravines also occurs, behind woody debris jams as well as in locations where local baselevel has been raised by the insertion of a culvert. The sediment budget of the ravines would be quantified as the difference between the storage of sediment and the sum of sediments loads derived from the uplands, as well as the bluffs and terraces inside the ravines. Primary locations of major bluffs, terraces, gullies and drainage tiles in the gauged ravines were mapped using GPS. A database of major bluff, terraces, and drainage tiles was built in ArcGIS. Sediment samples from ravine heads, bluffs, terraces and ravine mouth were collected to study the grain size distribution and stratigraphy of major bluffs along the ravines. Sediment transport in the ravines will be modeled using MIKE 11 (DHI group), a dynamic, one

Bi-criteria evaluation of the MIKE SHE model for a forested watershed on the South Carolina coastal plain

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Z. Dai

2010-06-01

Full Text Available Hydrological models are important tools for effective management, conservation and restoration of forested wetlands. The objective of this study was to test a distributed hydrological model, MIKE SHE, by using bi-criteria (i.e., two measurable variables, streamflow and water table depth to describe the hydrological processes in a forested watershed that is characteristic of the lower Atlantic Coastal Plain. Simulations were compared against observations of both streamflow and water table depth measured on a first-order watershed (WS80 on the Santee Experimental Forest in South Carolina, USA. Model performance was evaluated using coefficient of determination (R² and Nash-Sutcliffe's model efficiency (E. The E and root mean squared error (RMSE were chosen as objective functions for sensitivity analysis of parameters. The model calibration and validation results demonstrated that the streamflow and water table depth were sensitive to most of the model input parameters, especially to surface detention storage, drainage depth, soil hydraulic properties, plant rooting depth, and surface roughness. Furthermore, the bi-criteria approach used for distributed model calibration and validation was shown to be better than the single-criterion in obtaining optimum model input parameters, especially for those parameters that were only sensitive to some specific conditions. Model calibration using the bi-criteria approach should be advantageous for constructing the uncertainty bounds of model inputs to simulate the hydrology for this type of forested watersheds. R² varied from 0.60–0.99 for daily and monthly streamflow, and from 0.52–0.91 for daily water table depth. E changed from 0.53–0.96 for calibration and 0.51–0.98 for validation of daily and monthly streamflow, while E varied from 0.50–0.90 for calibration and 0.66–0.80 for validation of daily water table depth. This study showed

Looming Over the Nation, Uneasy with the Folks: Locating Mike de Leon in Philippine Cinema

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Patrick F. Campos

2006-12-01

Full Text Available The article draws on filmic, popular, and scholarly references in order to trace how Mike de Leon and his films have been regarded, since his landmark entrance into Philippine cinema as director, up to the present. Specifically, it locates De Leon within the subtly shifting discourse of nationalist film scholarship and historicizing, and discusses how he and his films are written about, identified, associated or networked with other filmmakers and films, or utilized in discourses about the Philippines, Philippine cinema, or Philippine culture.The article locates De Leon as (1 an insider of Philippine cinema history, (2 an outsider of the commercial film industry, and (3 a hero of the mythic Golden Age of the National Cinema. It also maps out his filmography within the nationalist agenda; appraises what filmmakers, commentators, and scholars have articulated about his films; and analyzes the thematic and stylistic trajectories of his later works. Finally, it discusses how De Leon is being written into today’s discourse of Philippine cinema.

The application of Mike Urban model in drainage and waterlogging in Lincheng county, China

Science.gov (United States)

Luan, Qinghua; Zhang, Kun; Liu, Jiahong; Wang, Dong; Ma, Jun

2018-06-01

Recently, the water disaster in cities especially in Chinese mountainous cities is more serious, due to the coupling influences of waterlogging and regional floods. It is necessary to study the surface runoff process of mountainous cities and examine the regional drainage pipeline network. In this study, the runoff processes of Lincheng county (located in Hebei province, China) in different scenarios were simulated through Mike Urban model. The results show that all of the runoff process of the old town and the new residential area with larger slope, is significant and full flow of these above zones exists in the part of the drainage pipeline network; and the overflow exists in part of the drainage pipeline network when the return period is ten years or twenty years, which illuminates that the waterlogging risk in this zone of Lincheng is higher. Therefore, remodeling drainage pipeline network in the old town of Lincheng and adding water storage ponds in the new residential areas were suggested. This research provides both technical support and decision-making reference to local storm flood management, also give the experiences for the study on the runoff process of similar cities.

An editorial approach: Mike Nelson’s corridors and The Deliverance and The Patience

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Helen Hughes

2015-06-01

Full Text Available This essay contrasts the contemporary British artist Mike Nelson’s approach to constructing his large, multi-room installations with his approach to editing the numerous artist books that he has produced since 2000. This comparison reveals several compositional symmetries between the two, namely pertaining to narrative non-linearity and meta-fictionality. The logic of montage is shown to similarly underscore both the books and the installations. This essay argues that the corridors connecting the different rooms of Nelson’s installations function in a similar way to the logic of montage: they play an integral role as the support that binds the structure of the installation (its multiple rooms together as a whole. This essay argues that the corridor is the primary viewing framework of the installation for the viewer, and that this vantage point is significant because the necessarily partial vision of the installation from the space of the corridor demonstrates the logic of installation art more broadly. I conclude by mapping the key compositional elements of Nelson’s artist books onto his installations, taking the 2001 work The Deliverance and The Patience as a case study, to show that the books do not exemplify the artwork as with traditional exhibition catalogues, but rather parallel it. That is, a structural continuity is established between these two facets of his work.

River Flow Prediction for Future Climate Using Long Series of Multi-Site Synthetic Data and MIKE SHE Model

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Kuchar Leszek

2017-01-01

Full Text Available A new simulation of daily flow for Kaczawa River, south-west Poland for extra long series of generated meteorological data (comparing to previous research and selected climate change scenarios are presented. The Representative Concentration Pathways (RCPs scenarios vs. SRES are introduced for simulations. The flow simulation in the river catchment is made using MIKE SHE hydrological model while the multisite data are generated by spatial weather generator SWGEN. Simulations are done for 2040 and 2060 while the simulations for the year 2000 are used as a background. The large number of new simulated series determined by the lead time, three climate change scenarios (RCP2.6 RCP4.5 and RCP6.0, and number of generated years (1000 for each case is equal to 7000 for a single station. Finally, Pdf function for flow is presented as well probability of exceedance of maximum flow.

Validating Stormwater system simulations in Edmonton Using MIKE URBAN

Science.gov (United States)

Gaafar, M.

2016-12-01

Many municipalities use chloramination to disinfect drinking water so as to avert the production of the disinfection by-products (DBPs) that result from conventional chlorination processes and the consequential public health risks. However, the long-lasting monochloramine disinfectant (NH2Cl) can pose a significant risk to the environment. As, it can be introduced into stormwater sewers and thus freshwater sources. This study was intended to investigate decay of NH2Cl in stormwater networks starting by building a stormwater model and validating its hydraulic and hydrologic computations, and then modelling water quality in the storm sewers. The presented work here is only the first stage of this study. The 30th Avenue basin in Edmonton was chosen as a case study, because it has various land-use types including commercial, industrial, residential and parks. The City of Edmonton has already built a MIKE-URBAN stormwater model for modelling floods. However, this model was built to the trunk level where only the main drainage features were presented. Also, this model was not calibrated and known to consistently compute pipe flows higher than the observed values; not to the benefit of studying water quality. So the first goal was to complete modelling and updating the real stormwater network. Then, available GIS Data was used to calculate different catchment properties such as slope, length and imperviousness. To calibrate and validate this model, data of two temporary pipe flow monitoring stations was used along with records of two other permanent stations available for eight consecutive summer seasons. The effect of various hydrological parameters on model results was investigated. It was found that model results were affected by the ratio of impervious areas. The catchment length was tested, however calculated, because it is approximate representation of the catchment shape. Surface roughness coefficients were calibrated using. Consequently, computed flows at the two

Werner Heisenberg. The language of the atoms. Life and work - a scientific biography - the ''joyous science'' (youth until Nobel price); Werner Heisenberg. Die Sprache der Atome. Leben und Wirken - Eine wissenschaftliche Biographie - Die ''froehliche Wissenschaft'' (Jugend bis Nobelpreis)

Energy Technology Data Exchange (ETDEWEB)

Rechenberg, Helmut [MPI fuer Physik, Muenchen (Germany). Werner-Heisenberg-Institut

2010-07-01

With his discovery that measuring values of complementary fundamental quantities in the microscopic world cannot by arbitrarily precisely determined cutted Werner Heisenberg the Gordian knot for the finishing of quantum theory developed by Planck, Einstein, and others and opened by this a new ''golden era'' in the physics of the 20th century. On the base of the documents from his life and work, i. e. deeds, letters and reports of contemporaries, as well as the published and unpublished essays, books, and articles of Heisenberg - also the later on found, publications or manuscripts mainly coming from the inheritance - resulted this systematic biography of Heisenberg. The author, the last doctoral candidate of Heisenberg relied furthermore on factual and personal knowledges, mainly own remembrances on his doctoral father and his teachers, colleagues, and students. Because of the interest of an authentical biography of the theoretical physicist Heisenberg the presentation of the mathematical approaches and the corresponding derivations could not completely be abandoned. This biography appeals by this both to a scientifically cultivated as a wider in science interested audience and covers the first phase of Heisenberg's life until his Nobel price 1933. [German] Mit seiner Entdeckung, dass sich Messwerte komplementaerer Groessen in der mikroskopischen Welt nicht beliebig genau bestimmen lassen, durchschnitt Werner Heisenberg den Gordischen Knoten zur Vollendung der von Planck, Einstein und anderen entwickelten Quantentheorie und eroeffnete damit ein neues ''goldenes Zeitalter'' in der Physik des 20. Jahrhunderts. Auf der Grundlage der Dokumente aus seinem Leben und Wirken, d.h. der Urkunden, Briefe und Berichte von Zeitzeugen sowie der publizierten und unpublizierten Abhandlungen, Buecher und Artikel Heisenbergs - auch der spaeter aufgefundenen, ueberwiegend aus dem Nachlass Heisenbergs stammenden Veroeffentlichungen oder

Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts

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Terence Davis

2016-04-01

Full Text Available Progeroid syndromes show features of accelerated ageing and are used as models for human ageing, of which Werner syndrome (WS is one of the most widely studied. WS fibroblasts show accelerated senescence that may result from p38 MAP kinase activation since it is prevented by the p38 inhibitor SB203580. Thus, small molecule inhibition of p38-signalling may be a therapeutic strategy for WS. To develop this approach issues such as the in vivo toxicity and kinase selectivity of existing p38 inhibitors need to be addressed, so as to strengthen the evidence that p38 itself plays a critical role in mediating the effect of SB203580, and to find an inhibitor suitable for in vivo use. In this work we used a panel of different p38 inhibitors selected for: (1 having been used successfully in vivo in either animal models or human clinical trials; (2 different modes of binding to p38; and (3 different off-target kinase specificity profiles, in order to critically address the role of p38 in the premature senescence seen in WS cells. Our findings confirmed the involvement of p38 in accelerated cell senescence and identified p38 inhibitors suitable for in vivo use in WS, with BIRB 796 the most effective.

An Englishman in Romania: An Imagological Reading of Mike Ormsby’s Never Mind the Balkans, Here’s Romania

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Gabriela-Iuliana COLIPCĂ-CIOBANU

2014-12-01

Full Text Available Connecting back with an already well-established tradition of scholarly explorations of images of Romanianness, as emerging from (nonfictional representations of cross-cultural, Anglo-Romanian encounters, the present paper focuses on one of the most recent textual productions foregrounding an English traveller’s gaze on his Romanian hosts, namely Mike Ormsby’s collection of short stories Never Mind the Balkans, Here’s Romania (2008. Applying an imagological grid to it, the paper aims at providing evidence in defence of the idea that, at least after 1989, the English observers’ attitudes towards and, implicitly, textual mirroring of Romania have undergone significant changes. In doing that, it reflects upon the ‘game’ of auto- and hetero-images at the heart of the narrative discourse as meant to point to both an awareness of cultural differences and the need to overcome cultural biases in one’s mind with a view to successful intercultural communication in the context of globalisation-driven societal transformations.

Werner Heisenberg; Werner Heisenberg

Energy Technology Data Exchange (ETDEWEB)

Schiemann, G.

2008-07-01

This book contains a biography of Heisenberg, a description of the development of quantum mechanics, a consideration of connections of philosophy and physics, and a description of the scientific picture of the world. Finally a list of books written by Heisenberg respectively connected with his work is presented. (HSI)

Acrolein-exposed normal human lung fibroblasts in vitro: cellular senescence, enhanced telomere erosion, and degradation of Werner's syndrome protein.

Science.gov (United States)

Jang, Jun-Ho; Bruse, Shannon; Huneidi, Salam; Schrader, Ronald M; Monick, Martha M; Lin, Yong; Carter, A Brent; Klingelhutz, Aloysius J; Nyunoya, Toru

2014-09-01

Acrolein is a ubiquitous environmental hazard to human health. Acrolein has been reported to activate the DNA damage response and induce apoptosis. However, little is known about the effects of acrolein on cellular senescence. We examined whether acrolein induces cellular senescence in cultured normal human lung fibroblasts (NHLF). We cultured NHLF in the presence or absence of acrolein and determined the effects of acrolein on cell proliferative capacity, senescence-associated β-galactosidase activity, the known senescence-inducing pathways (e.g., p53, p21), and telomere length. We found that acrolein induced cellular senescence by increasing both p53 and p21. The knockdown of p53 mediated by small interfering RNA (siRNA) attenuated acrolein-induced cellular senescence. Acrolein decreased Werner's syndrome protein (WRN), a member of the RecQ helicase family involved in DNA repair and telomere maintenance. Acrolein-induced down-regulation of WRN protein was rescued by p53 knockdown or proteasome inhibition. Finally, we found that acrolein accelerated p53-mediated telomere shortening. These results suggest that acrolein induces p53-mediated cellular senescence accompanied by enhanced telomere attrition and WRN protein down-regulation.

Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2

Science.gov (United States)

Edwards, Deanna N.; Orren, David K.; Machwe, Amrita

2014-01-01

Werner syndrome (WS), caused by loss of function of the RecQ helicase WRN, is a hereditary disease characterized by premature aging and elevated cancer incidence. WRN has DNA binding, exonuclease, ATPase, helicase and strand annealing activities, suggesting possible roles in recombination-related processes. Evidence indicates that WRN deficiency causes telomeric abnormalities that likely underlie early onset of aging phenotypes in WS. Furthermore, TRF2, a protein essential for telomere protection, interacts with WRN and influences its basic helicase and exonuclease activities. However, these studies provided little insight into WRN's specific function at telomeres. Here, we explored the possibility that WRN and TRF2 cooperate during telomeric recombination processes. Our results indicate that TRF2, through its interactions with both WRN and telomeric DNA, stimulates WRN-mediated strand exchange specifically between telomeric substrates; TRF2's basic domain is particularly important for this stimulation. Although TRF1 binds telomeric DNA with similar affinity, it has minimal effects on WRN-mediated strand exchange of telomeric DNA. Moreover, TRF2 is displaced from telomeric DNA by WRN, independent of its ATPase and helicase activities. Together, these results suggest that TRF2 and WRN act coordinately during telomeric recombination processes, consistent with certain telomeric abnormalities associated with alteration of WRN function. PMID:24880691

Numerical Limitations of 1D Hydraulic Models Using MIKE11 or HEC-RAS software - Case study of Baraolt River, Romania

Science.gov (United States)

Andrei, Armas; Robert, Beilicci; Erika, Beilicci

2017-10-01

MIKE 11 is an advanced hydroinformatic tool, a professional engineering software package for simulation of one-dimensional flows in estuaries, rivers, irrigation systems, channels and other water bodies. MIKE 11 is a 1-dimensional river model. It was developed by DHI Water · Environment · Health, Denmark. The basic computational procedure of HEC-RAS for steady flow is based on the solution of the one-dimensional energy equation. Energy losses are evaluated by friction and contraction / expansion. The momentum equation may be used in situations where the water surface profile is rapidly varied. These situations include hydraulic jumps, hydraulics of bridges, and evaluating profiles at river confluences. For unsteady flow, HEC-RAS solves the full, dynamic, 1-D Saint Venant Equation using an implicit, finite difference method. The unsteady flow equation solver was adapted from Dr. Robert L. Barkau’s UNET package. Fluid motion is controlled by the basic principles of conservation of mass, energy and momentum, which form the basis of fluid mechanics and hydraulic engineering. Complex flow situations must be solved using empirical approximations and numerical models, which are based on derivations of the basic principles (backwater equation, Navier-Stokes equation etc.). All numerical models are required to make some form of approximation to solve these principles, and consequently all have their limitations. The study of hydraulics and fluid mechanics is founded on the three basic principles of conservation of mass, energy and momentum. Real-life situations are frequently too complex to solve without the aid of numerical models. There is a tendency among some engineers to discard the basic principles taught at university and blindly assume that the results produced by the model are correct. Regardless of the complexity of models and despite the claims of their developers, all numerical models are required to make approximations. These may be related to geometric

The Great Detective, by Zach Dundas; Gender and the modern Sherlock Holmes, edited by Nadine Farghaly; and Sherlock Holmes, edited by Alex Werner [book review

Directory of Open Access Journals (Sweden)

Julia Knaus

2017-03-01

Full Text Available Review of: Zach Dundas. The Great Detective: The amazing rise and immortal life of Sherlock Holmes. Boston: Houghton Mifflin Harcourt, 2015, hardcover, $26 (336p, ISBN 978-0-544-21404-0, e-book $15.95 (2378 KB, ISBN 978-0-544-22020-1, ASIN B00LZ7GP6U. Nadine Farghaly, ed. Gender and the modern Sherlock Holmes: Essays on film and television adaptations since 2009. Jefferson, NC: McFarland, 2015, paperback, $35 (260p, ISBN 978-0-786-49459-0, e-book $9.99 (3353 KB, ISBN 978-1-4766-2281-1, ASIN B019WQQEY8. Alex Werner, ed. Sherlock Holmes: The man who never lived and will never die. London: Ebury Press, 2014, hardcover, £25 (256p, ISBN 978-0-09-195872-5, e-book £12.99, ISBN 978-1-47-350264-2.

Parametric source of two-photon states with a tunable degree of entanglement and mixing: Experimental preparation of Werner states and maximally entangled mixed states

International Nuclear Information System (INIS)

Cinelli, C.; Di Nepi, G.; De Martini, F.; Barbieri, M.; Mataloni, P.

2004-01-01

A parametric source of polarization-entangled photon pairs with striking spatial characteristics is reported. The distribution of the output electromagnetic k modes excited by spontaneous parametric down-conversion and coupled to the output detectors can be very broad. Using these states realized over a full entanglement ring output distribution, the nonlocal properties of the generated entanglement have been tested by standard Bell measurements and by Ou-Mandel interferometry. A 'mode-patchwork' technique based on the quantum superposition principle is adopted to synthesize in a straightforward and reliable way any kind of mixed state, of large conceptual and technological interest in modern quantum information. Tunable Werner states and maximally entangled mixed states have indeed been created by this technique and investigated by quantum tomography. A study of the entropic and nonlocal properties of these states has been undertaken experimentally and theoretically, by a unifying variational approach

Effects on surface hydrology and near-surface hydrogeology of an open repository in Laxemar Results of modelling with MIKE SHE

International Nuclear Information System (INIS)

Maartensson, Erik; Gustafsson, Lars-Goeran; Bosson, Emma

2009-10-01

This report presents the methodology and the results from the modelling of an open repository for spent nuclear fuel in Laxemar. Specifically, the present work analyses the hydrological effects of the planned repository during the construction and operational phases when it is open, i.e. air-filled, and hence may cause a disturbance of the hydrological conditions in the surroundings. The numerical modelling is based on the SDM-Site Laxemar MIKE SHE model. The modelling was divided into three steps. The first step was to update the SDM-Site Laxemar model with a new hydrogeological bedrock model. The other main updates were an increase of the depth of the MIKE SHE model domain, enhanced vertical computational resolution and that the drainage of the Aespoe Hard Rock Laboratory was included in the model. The resulting model was used to simulate undisturbed natural conditions. The next step was to describe the open repository conditions, using Laxemar layout D2, by implementing the access tunnel, the repository tunnels and shafts in the model, and to simulate the consequences for the surface hydrology caused by an open repository under different conditions. The final step was a sensitivity analysis that aimed to investigate the sensitivity of the modelled effects of the open repository to the hydrogeological properties of the bedrock and the Quaternary deposits, the sediments under the sea, and changes in boundary conditions. The model covers an area of 34 km 2 . The groundwater divides were assumed to coincide with the surface water divides; thus, a no-flow boundary condition was used at the horizontal boundaries, except in the Quaternary deposit layers towards the sea where a time-varying boundary condition describing the sea-level in the area was used. In the bedrock layers, however, a no-flow boundary condition was applied. Also the bottom boundary was described as a no-flow boundary. The transient top boundary condition was based on meteorological data gathered at

Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population

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M.A.C. Smith

2005-07-01

Full Text Available Werner syndrome (WS is a premature aging disease caused by a mutation in the WRN gene. The gene was identified in 1996 and its product acts as a DNA helicase and exonuclease. Some specific WRN polymorphic variants were associated with increased risk for cardiovascular diseases. The identification of genetic polymorphisms as risk factors for complex diseases affecting older people can improve their prevention, diagnosis and prognosis. We investigated WRN codon 1367 polymorphism in 383 residents in a district of the city of São Paulo, who were enrolled in an Elderly Brazilian Longitudinal Study. Their mean age was 79.70 ± 5.32 years, ranging from 67 to 97. This population was composed of 262 females (68.4% and 121 males (31.6% of European (89.2%, Japanese (3.3%, Middle Eastern (1.81%, and mixed and/or other origins (5.7%. There are no studies concerning this polymorphism in Brazilian population. These subjects were evaluated clinically every two years. The major health problems and morbidities affecting this cohort were cardiovascular diseases (21.7%, hypertension (83.7%, diabetes (63.3%, obesity (41.23%, dementia (8.0%, depression (20.0%, and neoplasia (10.8%. Their prevalence is similar to some urban elderly Brazilian samples. DNA was isolated from blood cells, amplified by PCR and digested with PmaCI. Allele frequencies were 0.788 for the cysteine and 0.211 for the arginine. Genotype distributions were within that expected for the Hardy-Weinberg equilibrium. Female gender was associated with hypertension and obesity. Logistic regression analysis did not detect significant association between the polymorphism and morbidity. These findings confirm those from Europeans and differ from Japanese population.

Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture.

Science.gov (United States)

Shimamoto, Akira; Kagawa, Harunobu; Zensho, Kazumasa; Sera, Yukihiro; Kazuki, Yasuhiro; Osaki, Mitsuhiko; Oshimura, Mitsuo; Ishigaki, Yasuhito; Hamasaki, Kanya; Kodama, Yoshiaki; Yuasa, Shinsuke; Fukuda, Keiichi; Hirashima, Kyotaro; Seimiya, Hiroyuki; Koyama, Hirofumi; Shimizu, Takahiko; Takemoto, Minoru; Yokote, Koutaro; Goto, Makoto; Tahara, Hidetoshi

2014-01-01

Werner syndrome (WS) is a premature aging disorder characterized by chromosomal instability and cancer predisposition. Mutations in WRN are responsible for the disease and cause telomere dysfunction, resulting in accelerated aging. Recent studies have revealed that cells from WS patients can be successfully reprogrammed into induced pluripotent stem cells (iPSCs). In the present study, we describe the effects of long-term culture on WS iPSCs, which acquired and maintained infinite proliferative potential for self-renewal over 2 years. After long-term cultures, WS iPSCs exhibited stable undifferentiated states and differentiation capacity, and premature upregulation of senescence-associated genes in WS cells was completely suppressed in WS iPSCs despite WRN deficiency. WS iPSCs also showed recapitulation of the phenotypes during differentiation. Furthermore, karyotype analysis indicated that WS iPSCs were stable, and half of the descendant clones had chromosomal profiles that were similar to those of parental cells. These unexpected properties might be achieved by induced expression of endogenous telomerase gene during reprogramming, which trigger telomerase reactivation leading to suppression of both replicative senescence and telomere dysfunction in WS cells. These findings demonstrated that reprogramming suppressed premature senescence phenotypes in WS cells and WS iPSCs could lead to chromosomal stability over the long term. WS iPSCs will provide opportunities to identify affected lineages in WS and to develop a new strategy for the treatment of WS.

Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture.

Directory of Open Access Journals (Sweden)

Akira Shimamoto

Full Text Available Werner syndrome (WS is a premature aging disorder characterized by chromosomal instability and cancer predisposition. Mutations in WRN are responsible for the disease and cause telomere dysfunction, resulting in accelerated aging. Recent studies have revealed that cells from WS patients can be successfully reprogrammed into induced pluripotent stem cells (iPSCs. In the present study, we describe the effects of long-term culture on WS iPSCs, which acquired and maintained infinite proliferative potential for self-renewal over 2 years. After long-term cultures, WS iPSCs exhibited stable undifferentiated states and differentiation capacity, and premature upregulation of senescence-associated genes in WS cells was completely suppressed in WS iPSCs despite WRN deficiency. WS iPSCs also showed recapitulation of the phenotypes during differentiation. Furthermore, karyotype analysis indicated that WS iPSCs were stable, and half of the descendant clones had chromosomal profiles that were similar to those of parental cells. These unexpected properties might be achieved by induced expression of endogenous telomerase gene during reprogramming, which trigger telomerase reactivation leading to suppression of both replicative senescence and telomere dysfunction in WS cells. These findings demonstrated that reprogramming suppressed premature senescence phenotypes in WS cells and WS iPSCs could lead to chromosomal stability over the long term. WS iPSCs will provide opportunities to identify affected lineages in WS and to develop a new strategy for the treatment of WS.

The Berlin Mission Society and German linguistic roots of volkekunde: The background, training and Hamburg writings of Werner Eiselen, 1899-1924

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Andrew Bank

Full Text Available This article presents a case for the centrality of race and racism in the training and early ethnographic writings of Werner Eiselen (1899-1977. Together with further discussion in two other articles, it demonstrates that Eiselen was not the consolidator of the British functionalist anthropological tradition in South Africa nor a strong affiliate of the liberal school of African studies in South Africa as other scholars have proposed. On the contrary, he was the founder of a radically different ethnographic tradition: an anti-humanist and deeply racialised tradition of cultural study with its roots in Berlin Mission Society ideology and German Africanist linguistics. I track the origins of Eiselens volkekunde to his missionary background in a former Boer Republic, his Afrikaner nationalist schooling and university career, and especially to his training in African linguistics in Hamburg (and Berlin between 1921 and 1924 under the leading international figure in the field, the German linguist and ethnologist Carl Meinhof (1857-1944, whose racially informed theories and politics profoundly shaped Eiselen and the school of volkekunde that he would father during his decade-long tenure at Stellenbosch University.

Therapeutic Group work for People with Cognitive Losses Therapeutic Groupwork for People with Cognitive Losses Mike Bender Speechmark 288 pp £37.50 0 86388 4067 0863884067 [Formula: see text].

Science.gov (United States)

2005-10-01

Mike Bender has provided a thoroughly accessible book that imparts information and guidance, and focuses effort. He quickly constructs a sound rationale for supporting therapeutic groupwork in people who experience cognitive loss. This theme runs throughout and is reinforced by positive experiences reported in the text. The author does not over-complicate or attempt to place groupwork in the hands of a skilled few; instead he shows that with planning, solid support from colleagues, attention to detail in preparation and by following some well-grounded 'rules', groupwork is available to most.

Evaluation of artificial groundwater recharge effects with MIKE-SHE: a case study.

Science.gov (United States)

Leal, M.; Martínez-García, I.; Carreño, F.; de Bustamante, I.; Lillo, J.

2012-04-01

In many areas where the technical and financial resources are limited, the treatment and disposal of wastewater comprise a problem. With increasing frequency, the wastewater reuse is considered as another alternative for water management alternative. In this way, the wastewater is converted into an added value resource. Treated wastewater infiltration into the soil could be a viable tertiary treatment, especially for small communities where the availability of land is not a problem and the wastewater has not industrial waste contribution and is highly biodegradable. The Experimental Plant of Carrión de los Céspedes (Seville, Spain) develops non-conventional wastewater treatments for small villages. Currently, a project regarding wastewater reutilization for aquifer recharge through a horizontal permeable reactive barrier and a subsequent soil infiltration is being carried out. One of the aspects to be evaluated within this context is the impact on aquifer. Consequently, the main goal of the present study is to assess the effects on the water flow derived from the future recharge activities by using the MIKE-SHE hydrological code. The unsaturated and saturated zones have been integrated in the model, which requires geological, land use, topography, piezometric head, soil and climate data to build up the model. The obtained results from the model show that with the annual recharge volume contributed by the experimental plant (3 m3 or 0.19 L/s) there is no effect in the groundwater flow. A volume of 400 m3/year (25 L/s) would be required to yield a variation in the piezometric head and therefore, in the groundwater flow i.e. a volume about 100 times larger than the estimated is necessary. To calibrate the model, simulated piezometric head values have been compared to the measured field data at a number of locations. In the calibration, the percent error had to be lower than 15 % at each location. Future works concerning groundwater quality and reactive transport

The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome

Energy Technology Data Exchange (ETDEWEB)

Trego, Kelly S.; Chernikova, Sophia B.; Davalos, Albert R.; Perry, J. Jefferson P.; Finger, L. David; Ng, Cliff; Tsai, Miaw-Sheue; Yannone, Steven M.; Tainer, John A.; Campisi, Judith; Cooper, Priscilla K.

2011-04-20

XPG is a structure-specific endonuclease required for nucleotide excision repair (NER). XPG incision defects result in the cancer-prone syndrome xeroderma pigmentosum, whereas truncating mutations of XPG cause the severe postnatal progeroid developmental disorder Cockayne syndrome. We show that XPG interacts directly with WRN protein, which is defective in the premature aging disorder Werner syndrome, and that the two proteins undergo similar sub-nuclear redistribution in S-phase and co-localize in nuclear foci. The co-localization was observed in mid- to late-S-phase, when WRN moves from nucleoli to nuclear foci that have been shown to contain protein markers of both stalled replication forks and telomeric proteins. We mapped the interaction between XPG and WRN to the C-terminal domains of each and show that interaction with the C-terminal domain of XPG strongly stimulates WRN helicase activity. WRN also possesses a competing DNA single-strand annealing activity that, combined with unwinding, has been shown to coordinate regression of model replication forks to form Holliday junction/chicken foot intermediate structures. We tested whether XPG stimulated WRN annealing activity and found that XPG itself has intrinsic strand annealing activity that requires the unstructured R- and C-terminal domains, but not the conserved catalytic core or endonuclease activity. Annealing by XPG is cooperative, rather than additive, with WRN annealing. Taken together, our results suggest a novel function for XPG in S-phase that is at least in part carried out coordinately with WRN, and which may contribute to the severity of the phenotypes that occur upon loss of XPG.

Instrumental Neutron Activation Analysis applied to the study of chemical element accumulation in organs of Rhinella schneideri (Werner, 1894)

Energy Technology Data Exchange (ETDEWEB)

Bardini Junior, Claudiney; Fernandes, Elisabete A. de Nadai, E-mail: lis@cena.usp.br [Centro de Energia Nuclear na Agricultura (CENA/USP), Piracicaba, SP (Brazil); Santos, Katarine M. Barbosa; Silva Neto, Luiz J. da; Santos, Robson A. dos; Silva, Karolayne E.M.; França, Elvis J. de, E-mail: ejfranca@cnen.gov.br [Centro Regional de Ciências Nucleares do Nordeste (DIAMB/CRCN-NE/CNEN-PE), Recife, PE (Brazil). Div. de Monitoração Ambiental

2017-07-01

Instrumental Neutron Activation Analysis (INAA) is a multielementar technique with high sensitivity, and can be applied to study small samples. Therefore, this research proposes using the INAA for quantifying the accumulation of chemical elements in organs of anuran amphibians Rhinella schneideri (Werner, 1894). Male individuals were collected on areas with anthropogenic influence close to water resources on the campus of ESALQ/USP in 2009. The animals were sacrificed in a cold chamber and dissected to separate their kidneys, livers, lungs and skins. After cleaning, the organs were lyophilized and pulverized. Samples weighing from 200 to 500 mg were placed in polyethylene capsules to be irradiated. The INAA technique, based on the bombardment of samples with neutrons for the production of radionuclides, was applied using the Nuclear Research Reactor of the Nuclear and Energy Research Institute. Portions of certified reference materials were used to evaluate the quality of the analytical procedure. The mass fractions were quantified by the k0 method, and the results indicated differences among the As, Br, Co, Cr, Fe, Hg, Sc, Se and Zn concentrations in the analyzed organs. Therefore, it was possible to calculate the bioaccumulation indexes relative to these chemical elements for the species. In addition, it was possible to infer the contamination pathways: As, Br, Co, Cr and Se by ingestion and Co, Fe, Hg, Sc and Zn by contact, which corroborated the usage of R. schneideri anuran as a biomonitor of chemical elements. (author)

ROVIBRATIONALLY RESOLVED DIRECT PHOTODISSOCIATION THROUGH THE LYMAN AND WERNER TRANSITIONS OF H2 FOR FUV/X-RAY-IRRADIATED ENVIRONMENTS

International Nuclear Information System (INIS)

Gay, C. D.; Porter, R. L.; Stancil, P. C.; Abel, N. P.; Ferland, G. J.; Shaw, G.; Van Hoof, P. A. M.; Williams, R. J. R.

2012-01-01

Using ab initio potential curves and dipole transition moments, cross-section calculations were performed for the direct continuum photodissociation of H 2 through the B 1 Σ + u 1 Σ + g (Lyman) and C 1 Π u 1 Σ + g (Werner) transitions. Partial cross-sections were obtained for wavelengths from 100 Å to the dissociation threshold between the upper electronic state and each of the 301 bound rovibrational levels v''J'' within the ground electronic state. The resulting cross-sections are incorporated into three representative classes of interstellar gas models: diffuse clouds, photon-dominated regions, and X-ray-dominated regions (XDRs). The models, which used the CLOUDY plasma/molecular spectra simulation code, demonstrate that direct photodissociation is comparable to fluorescent dissociation (or spontaneous radiative dissociation, the Solomon process) as an H 2 destruction mechanism in intense far-ultraviolet or X-ray-irradiated gas. In particular, changes in H 2 rotational column densities are found to be as large as 20% in the XDR model with the inclusion of direct photodissociation. The photodestruction rate from some high-lying rovibrational levels can be enhanced by pumping from H Lyβ due to a wavelength coincidence with cross-section resonances resulting from quasi-bound levels of the upper electronic states. Given the relatively large size of the photodissociation data set, a strategy is described to create truncated, but reliable, cross-section data consistent with the wavelength resolving power of typical observations.

Instrumental Neutron Activation Analysis applied to the study of chemical element accumulation in organs of Rhinella schneideri (Werner, 1894)

International Nuclear Information System (INIS)

Bardini Junior, Claudiney; Fernandes, Elisabete A. de Nadai; Santos, Katarine M. Barbosa; Silva Neto, Luiz J. da; Santos, Robson A. dos; Silva, Karolayne E.M.; França, Elvis J. de

2017-01-01

Instrumental Neutron Activation Analysis (INAA) is a multielementar technique with high sensitivity, and can be applied to study small samples. Therefore, this research proposes using the INAA for quantifying the accumulation of chemical elements in organs of anuran amphibians Rhinella schneideri (Werner, 1894). Male individuals were collected on areas with anthropogenic influence close to water resources on the campus of ESALQ/USP in 2009. The animals were sacrificed in a cold chamber and dissected to separate their kidneys, livers, lungs and skins. After cleaning, the organs were lyophilized and pulverized. Samples weighing from 200 to 500 mg were placed in polyethylene capsules to be irradiated. The INAA technique, based on the bombardment of samples with neutrons for the production of radionuclides, was applied using the Nuclear Research Reactor of the Nuclear and Energy Research Institute. Portions of certified reference materials were used to evaluate the quality of the analytical procedure. The mass fractions were quantified by the k0 method, and the results indicated differences among the As, Br, Co, Cr, Fe, Hg, Sc, Se and Zn concentrations in the analyzed organs. Therefore, it was possible to calculate the bioaccumulation indexes relative to these chemical elements for the species. In addition, it was possible to infer the contamination pathways: As, Br, Co, Cr and Se by ingestion and Co, Fe, Hg, Sc and Zn by contact, which corroborated the usage of R. schneideri anuran as a biomonitor of chemical elements. (author)

Analysis of efficiency of pollution reduction measures in rural basin using MIKE Basin model. Case study: Olšava River Basin

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Kaiglová Jana

2014-03-01

Full Text Available This paper presents the results of testing the applicability of the MIKE Basin model for simulating the efficiency of scenarios for reducing water pollution. The model has been tested on the Olšava River Basin (520 km2 which is a typical rural region with a heterogeneous mix of pollution sources with variable topography and land use. The study proved that the model can be calibrated successfully using even the limited amount of data typically available in rural basins. The scenarios of pollution reduction were based on implementation and intensification of municipal wastewater treatment and conversion of arable land on fields under the risk of soil erosion to permanent grassland. The application of simulation results of these scenarios with proposed measures proved decreasing concentrations in downstream monitoring stations. Due to the practical applicability of proposed measures, these could lead to fulfilment of the water pollution limits required by the Czech and EU legislation. However, there are factors of uncertainty that are discussed that may delay or limit the effect of adopted measures in small rural basins.

Praxis cultural / praxis política: el fracaso del Ateneo de la Juventud en México revolucionario

OpenAIRE

Fernández, Nora

2010-01-01

El proceso de la Revolución mexicana desatado durante 1910 tuvo su punto de inflexión histórica en la asunción de Francisco Madero como presidente de México en 1911 y en el marco sociopolítico donde se desarrolló la campaña electoral. La dictadura de Díaz era el blanco a demoler desde todas las esferas: la económico, la social y la cultural. La investigación sobre este período pretende, hasta donde es posible, dar cuenta de que en las fuentes históricas consultadas, como es el caso de Françoi...

Application of MIKE21 Software in Flood Routing of Tidal Rivers: A Case Study of the Zohre River

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Ali Karami Khaniki

2007-01-01

Full Text Available Flood routing is of special importance from different aspects of river engineering such as flood zoning, flood forecasting, etc. There are two methods employed in river flood routing, hydraulic and hydrological. Hydrological methods are used when the river is at low tide and, hence, cannot be employed to analyze floods caused by the tide. Hydraulic methods must be employed in tidal rivers when the direction of the current reverses at high tide. In this research,MIKE21 modeling software was used for the flood routing of the Zohreh tidal river. The model was calibrated by surveying the river, taking samples form the river bed, measuring sea water level and the velocity of the river flow. Analyzing the sensitivity of the model showed that the coefficient of determination, root mean square error and relative error were 0.95, 0.032, and 0.27, respectively, all indicating the efficacy of the model in simulating different parameters such as velocity, flow rate, and water surface profile. The flood routing results of the tidal currents showed that the hydrograph of the influent and effluent to the reach at high tide (when the current direction is from sea to the river was similar to the normal flood routing of the river, but at low tide (when the current direction is from the sea to the river influent and effluent hydrograph would not follow the laws of normal flood routing.

Competition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins

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Orren David K

2006-01-01

Full Text Available Abstract Background The premature aging and cancer-prone Werner and Bloom syndromes are caused by defects in the RecQ helicase enzymes WRN and BLM, respectively. Recently, both WRN and BLM (as well as several other RecQ members have been shown to possess a strand annealing activity in addition to the requisite DNA unwinding activity. Since an annealing function would appear to directly oppose the action of a helicase, we have examined in this study the dynamic equilibrium between unwinding and annealing mediated by either WRN or BLM. Results Our investigation into the competition between annealing and unwinding demonstrates that, under standard reaction conditions, WRN- or BLM-mediated annealing can partially or completely mask unwinding as measured in standard helicase assays. Several strategies were employed to suppress the annealing activity so that the actual strength of WRN- or BLM-dependent unwinding could be more accurately assessed. Interestingly, if a DNA oligomer complementary to one strand of the DNA substrate to be unwound is added during the helicase reaction, both WRN and BLM unwinding is enhanced, presumably by preventing protein-mediated re-annealing. This strategy allowed measurement of WRN-catalyzed unwinding of long (80 base pair duplex regions and fully complementary, blunt-ended duplexes, both of which were otherwise quite refractory to the helicase activity of WRN. Similarly, the addition of trap strand stimulated the ability of BLM to unwind long and blunt-ended duplexes. The stimulatory effect of the human replication protein A (hRPA, the eukaryotic single-stranded DNA binding protein on both WRN- and BLM-dependent unwinding was also re-examined in light of its possible role in preventing re-annealing. Our results show that hRPA influences the outcome of WRN and BLM helicase assays by both inhibiting re-annealing and directly promoting unwinding, with the larger contribution from the latter mechanism. Conclusion These

Mike Lynch

DEFF Research Database (Denmark)

Horst, Maja; Irwin, Alan

associated with this position and especially its relationship to STS traditions of policy relevance and engagement. What does it mean for STS to do its job? Or rather, what does it mean for us to do our jobs? Taking inspiration both from Lynch’s published work and the different ways he has performed his STS...... jobs, this presentation will discuss the relationship between vacation, work, professional ethos and personal contribution in the context of STS.......In ’Science as a vacation’, Michael Lynch argues that ’STS might aim for something other than the serious job of doing business’. In so doing, he makes a strong case for an STS that does not aim to be useful but instead does ‘its own job’. In our presentation, we will explore some of the challenges...

Alfred Werner

Indian Academy of Sciences (India)

Suppose we were to say, "Apple pie is in itself neither good nor bad; it is the way it is used that determines its value." ... There is nothing in the Sarnoff statement that will bear scrutiny, for it ignores the nature of the medium, of any and all media, in the true Narcissus style of one hypnotized by the amputation and extension of ...

Multi-site calibration, validation, and sensitivity analysis of the MIKE SHE Model for a large watershed in northern China

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S. Wang

2012-12-01

Full Text Available Model calibration is essential for hydrologic modeling of large watersheds in a heterogeneous mountain environment. Little guidance is available for model calibration protocols for distributed models that aim at capturing the spatial variability of hydrologic processes. This study used the physically-based distributed hydrologic model, MIKE SHE, to contrast a lumped calibration protocol that used streamflow measured at one single watershed outlet to a multi-site calibration method which employed streamflow measurements at three stations within the large Chaohe River basin in northern China. Simulation results showed that the single-site calibrated model was able to sufficiently simulate the hydrographs for two of the three stations (Nash-Sutcliffe coefficient of 0.65–0.75, and correlation coefficient 0.81–0.87 during the testing period, but the model performed poorly for the third station (Nash-Sutcliffe coefficient only 0.44. Sensitivity analysis suggested that streamflow of upstream area of the watershed was dominated by slow groundwater, whilst streamflow of middle- and down- stream areas by relatively quick interflow. Therefore, a multi-site calibration protocol was deemed necessary. Due to the potential errors and uncertainties with respect to the representation of spatial variability, performance measures from the multi-site calibration protocol slightly decreased for two of the three stations, whereas it was improved greatly for the third station. We concluded that multi-site calibration protocol reached a compromise in term of model performance for the three stations, reasonably representing the hydrographs of all three stations with Nash-Sutcliffe coefficient ranging from 0.59–072. The multi-site calibration protocol applied in the analysis generally has advantages to the single site calibration protocol.

[Werner Leibbrand, Annemarie Wettley and controversies on "euthanasia" the background of medico-historical and ethical debates in the Post World War II era].

Science.gov (United States)

Wiesinger, Christine; Frewer, Andreas

2014-01-01

Psychiatrists and medical historians Werner Leibbrand (1896 - 1974) and Annemarie Wettley (1913 - 1996) are amongst the most striking figures in the field of history of medicine. Leibbrand was appointed director of the "Heil- und Pflegeanstalt" in Erlangen shortly after the war. Fuelled by his own experiences of suppression and persecution during the Nazi era he promised to unearth the crimes and atrocities which had happened under watch of the Nazi regime. He was joined by Annemarie Wettley, who worked as a physician at the hospital and had developed an increasing interest in the history of medicine. In 1946 they published "Um die Menschenrechte der Geisteskranken" ("Human Rights of the Mentally Ill") about the "euthanasia" campaign of the Nazi regime. Although a number of substantial works followed, Leibbrand and Wettley failed to inform in more depth on crimes and atrocities, for instance killings of patients and forced malnutrition. Doubts and charges against Wettley regarding her role in dietary programmes at the Erlangen hospital and against Leibbrand regarding special expert's reports--both had a short-term arrest warrant--might have contributed to stagnation in their efforts. In 1953 Leibbrand accepted the offer of a chair at the University in Munich, Wettley followed and habilitated in history of medicine; in the year 1962 they married. Contacts and exchange amongst medico-historical experts shed light on developments during the post-war era; still, a critical and fundamental review of the crimes within the medical system of the Nazi regime did not take place during this time.

Feria de Milán. Pabellón de maquinaria pesada

Directory of Open Access Journals (Sweden)

Covre, Gino

1960-04-01

Full Text Available Después de demoler el edificio destinado a las exposiciones de los adelantos y mejoras de la mecánica pesada, las autoridades Que rigen estas manifestaciones de la mecánica en Milán, Italia, se entregaron a un estudio de conjunto del problema que para ellos constituía la construcción de un pabellón que sustituyera al destruido y que, tanto por sus condiciones intrínsecas como por su aspecto estático y funcional, supliera ampliamente a su antecesor. El solar disponible constituía una amplia parcela aislada, y se pensó, en principio, en un cuerpo arquitectónico de dos plantas, una en semisótano y otra superior que constituiría la sala general de las exposiciones.

ANALYSIS OF EROSION AND SEDIMENTATION PATTERNS USING SOFTWARE OF MIKE 21 HDFM-MT IN THE KAPUAS MURUNG RIVER MOUTH CENTRAL KALIMANTAN PROVINCE

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Franto Novico

2017-07-01

Full Text Available The public transportation system along the Kapuas River, Central Kalimantan are highly depend on water transportation. Natural condition gives high distribution to the smoothness of the vessel traffic along the Kapuas Murung River. The local government has planned to build specific port for stock pile at the Batanjung which would face with natural phenomena of sedimentation and erosion at a river mouth. Erosion and sedimentation could be predicted not only by field observing but it is also needed hypotheses using software analysis. Hydrodynamics and transport sediment models by Mike 21 HDFM-MT software will be applied to describe the position of sedimentations and erosions at a river mouth. Model is assumed by two different river conditions, wet and dry seasons. Based on two types of conditions the model would also describe the river flow and sediment transport at spring and neap periods. Tidal fluctuations and a river current as field observation data would be verified with the result of model simulations. Based on field observation and simulation results could be known the verification of tidal has an 89.74% correlation while the river current correlation has 43.6%. Moreover, based on the simulation the sediment patterns in flood period have a larger area than ebb period. Furthermore, the erosion patterns dominantly occur during wet and dry season within ebb period. Water depths and sediment patterns should be considered by the vessels that will use the navigation channel at a river mouth.

Local models and hidden nonlocality in Quantum Theory

OpenAIRE

Guerini, Leonardo

2014-01-01

This Master's thesis has two central subjects: the simulation of correlations generated by local measurements on entangled quantum states by local hidden-variables models and the revelation of hidden nonlocality. We present and detail the Werner's local model and the hidden nonlocality of some Werner states of dimension $d\\geq5$, the Gisin-Degorre's local model for a Werner state of dimension $d=2$ and the local model of Hirsch et al. for mixtures of the singlet state and noise, all of them f...

Application of MIKE SHE to study the impact of coal mining on river runoff in Gujiao mining area, Shanxi, China.

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Jianhua Ping

Full Text Available Coal mining is one of the core industries that contribute to the economic development of a country but deteriorate the environment. Being the primary source of energy, coal has become essential to meet the energy demand of a country. It is excavated by both opencast and underground mining methods and affects the environment, especially hydrological cycle, by discharging huge amounts of mine water. Natural hydrological processes have been well known to be vulnerable to human activities, especially large scale mining activities, which inevitably generate surface cracks and subsidence. It is therefore valuable to assess the impact of mining on river runoff for the sustainable development of regional economy. In this paper, the impact of coal mining on river runoff is assessed in one of the national key coal mining sites, Gujiao mining area, Shanxi Province, China. The characteristics of water cycle are described, the similarities and differences of runoff formation are analyzed in both coal mining and pre-mining periods. The integrated distributed hydrological model named MIKE SHE is employed to simulate and evaluate the influence of coal mining on river runoff. The study shows that mining one ton of raw coal leads to the reduction of river runoff by 2.87 m3 between 1981 and 2008, of which the surface runoff decreases by 0.24 m3 and the baseflow by 2.63 m3. The reduction degree of river runoff for mining one ton of raw coal shows an increasing trend over years. The current study also reveals that large scale coal mining initiates the formation of surface cracks and subsidence, which intercepts overland flow and enhances precipitation infiltration. Together with mine drainage, the natural hydrological processes and the stream flows have been altered and the river run off has been greatly reduced.

Application of MIKE SHE to study the impact of coal mining on river runoff in Gujiao mining area, Shanxi, China.

Science.gov (United States)

Ping, Jianhua; Yan, Shiyan; Gu, Pan; Wu, Zening; Hu, Caihong

2017-01-01

Coal mining is one of the core industries that contribute to the economic development of a country but deteriorate the environment. Being the primary source of energy, coal has become essential to meet the energy demand of a country. It is excavated by both opencast and underground mining methods and affects the environment, especially hydrological cycle, by discharging huge amounts of mine water. Natural hydrological processes have been well known to be vulnerable to human activities, especially large scale mining activities, which inevitably generate surface cracks and subsidence. It is therefore valuable to assess the impact of mining on river runoff for the sustainable development of regional economy. In this paper, the impact of coal mining on river runoff is assessed in one of the national key coal mining sites, Gujiao mining area, Shanxi Province, China. The characteristics of water cycle are described, the similarities and differences of runoff formation are analyzed in both coal mining and pre-mining periods. The integrated distributed hydrological model named MIKE SHE is employed to simulate and evaluate the influence of coal mining on river runoff. The study shows that mining one ton of raw coal leads to the reduction of river runoff by 2.87 m3 between 1981 and 2008, of which the surface runoff decreases by 0.24 m3 and the baseflow by 2.63 m3. The reduction degree of river runoff for mining one ton of raw coal shows an increasing trend over years. The current study also reveals that large scale coal mining initiates the formation of surface cracks and subsidence, which intercepts overland flow and enhances precipitation infiltration. Together with mine drainage, the natural hydrological processes and the stream flows have been altered and the river run off has been greatly reduced.

Viis armastuslugu suurel ekraanil / Tristan Priimägi

Index Scriptorium Estoniae

Priimägi, Tristan, 1976-

2008-01-01

Viis näidet filmiajaloost, kus režissööri ja staari vahel on tunded : Roger Vadim ja Tema Naised, Werner Herzog ja Klaus Kinski, Federico Fellini ja Anita Ekberg, Quentin Tarantino ja Uma Thurman, Rainer Werner Fassbinder ja Mr/Mrs X

Theories of Intelligence, Learning, and Motivation as a Basis for Praxis

Science.gov (United States)

Nderu-Boddington, Eulalee

2008-01-01

This paper examines how Piaget, Werner, and Gardner differ regarding the roles of cognition, intelligence, and learning in the developmental process. Piaget believes in the predominance of genetic factors. Werner stresses the influence of biological factors, while Gardner proposes that the environment plays a greater influence in how intelligence…

R-ES-ONAN-CE

Indian Academy of Sciences (India)

Birth of Quantum Electronics - Masers. Amit Roy. 14 Numeracy for Everyone. Anil P Gore and S A ... order Compounds. Alfred Werner. Front Cover. -_. --::::::-~: Back Cover. A few eye mutants of DrosfJphila melanogasfer. (See the Classroom section for more details). Alfred Werner. (1866 - 1919). (Illustration by Anindya Das).

I grandi della fisica da Platone a Heisenberg

CERN Document Server

Von Weizsäcker, Carl Friedrich

2002-01-01

Parmenide ; Platone ; Aristotele ; Copernico, Keplero, Galilei ; Galileo Galilei ; Cartesio ; Gottfried Wilhelm Leibniz ; Cartesio, Newton, Leibniz, Kant ; Immanuel Kant ; Johann Wolfgang Goethe ; Robert Meyer ; Albert Einstein ; Niels Bohr ; Paul Adrien Maurice Dirac ; Niels Bohr e Werner Heisenberg, un ricordo del 1932 ; Werner Heisenberg ; Heisenberg, fisico e filosofo ; l'interpretazione filosofica della fisica moderna.

Laureates

Science.gov (United States)

BAUTISTA JEFF BROUGHTON DOUG BURKHARDT TINA DECLERCK STEPHANIE COLLINS THOMAS DAVIS BRENT DRANEY KATHY EIDSON STEVE FILIPPOFF JEFF GROUNDS JIM HASLAM JACK HEFFERNAN SCOTT HOBBS LISA HUNT ERNIE JEW KATHERINE JOHNSON GLENN KERIN MIKE KINCAID TODD LABERGE KEITH LAFORGA MIKE LEE MIKE MAGUIRE JIM MURPHY DENNIS

Acetylation regulates WRN catalytic activities and affects base excision DNA repair

DEFF Research Database (Denmark)

Muftuoglu, Meltem; Kusumoto, Rika; Speina, Elzbieta

2008-01-01

The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by histone...... acetyltransferases is of key interest because of its potential importance in aging, DNA repair and transcription....

Mike Davis, Génocides tropicaux. Catastrophes naturelles et famines coloniales (1870-1900. Aux origines du sous-développement, Paris, La Découverte, 2003, 479 p., trad. Late Victorian Holocausts, El Niño Famines and the Making of the Third World, 2001.

Directory of Open Access Journals (Sweden)

Cyrille Ferraton

2005-04-01

Full Text Available C’est à une histoire en grande partie négligée et méconnue qu’est consacré l’ouvrage de Mike Davis Génocides tropicaux publié en 2001 sous le titre Late Victorian Holocausts, El Niño Famines and the Making of the Third World. L’Inde, la Chine, le Brésil, l’Afrique du Nord, l’Afrique australe, les Philippines, en fait, un grand nombre de pays qu’Alfred Sauvy désignera en 1952 par pays du « tiers-monde », connurent à la fin du XIXe siècle et au tout début du XXe siècle trois périodes climatique...

Evaluation of various modelling approaches in flood routing simulation and flood area mapping

Science.gov (United States)

Papaioannou, George; Loukas, Athanasios; Vasiliades, Lampros; Aronica, Giuseppe

2016-04-01

An essential process of flood hazard analysis and mapping is the floodplain modelling. The selection of the modelling approach, especially, in complex riverine topographies such as urban and suburban areas, and ungauged watersheds may affect the accuracy of the outcomes in terms of flood depths and flood inundation area. In this study, a sensitivity analysis implemented using several hydraulic-hydrodynamic modelling approaches (1D, 2D, 1D/2D) and the effect of modelling approach on flood modelling and flood mapping was investigated. The digital terrain model (DTMs) used in this study was generated from Terrestrial Laser Scanning (TLS) point cloud data. The modelling approaches included 1-dimensional hydraulic-hydrodynamic models (1D), 2-dimensional hydraulic-hydrodynamic models (2D) and the coupled 1D/2D. The 1D hydraulic-hydrodynamic models used were: HECRAS, MIKE11, LISFLOOD, XPSTORM. The 2D hydraulic-hydrodynamic models used were: MIKE21, MIKE21FM, HECRAS (2D), XPSTORM, LISFLOOD and FLO2d. The coupled 1D/2D models employed were: HECRAS(1D/2D), MIKE11/MIKE21(MIKE FLOOD platform), MIKE11/MIKE21 FM(MIKE FLOOD platform), XPSTORM(1D/2D). The validation process of flood extent achieved with the use of 2x2 contingency tables between simulated and observed flooded area for an extreme historical flash flood event. The skill score Critical Success Index was used in the validation process. The modelling approaches have also been evaluated for simulation time and requested computing power. The methodology has been implemented in a suburban ungauged watershed of Xerias river at Volos-Greece. The results of the analysis indicate the necessity of sensitivity analysis application with the use of different hydraulic-hydrodynamic modelling approaches especially for areas with complex terrain.

Effect of two-qutrit entanglement on quantum speed limit time of a bipartite V-type open system

Energy Technology Data Exchange (ETDEWEB)

Behzadi, N., E-mail: n.behzadi@tabrizu.ac.ir [Research Institute for Fundamental Sciences, University of Tabriz (Iran, Islamic Republic of); Ahansaz, B.; Ektesabi, A.; Faizi, E. [Physics Department, Azarbaijan Shahid Madani University, Tabriz (Iran, Islamic Republic of)

2017-03-15

In the present paper, quantum speed limit (QSL) time of a bipartite V-type three-level atomic system under the effect of two-qutrit entanglement is investigated. Each party interacts with own independent reservoir. By considering two local unitarily equivalent Werner states and the Horodecki PPT state, as initial states, the QSL time is evaluated for each of them in the respective entangled regions. It is counterintuitively observed that the effect of entanglement on the QSL time driven from each of the initial Werner states are completely different when the degree of non-Markovianity is considerable. In addition, it is interesting that the effect of entanglement of the non-equivalent Horodecki state on the calculated QSL time displays an intermediate behavior relative to the cases obtained for the Werner states.

Writing My Way to My Future | Poster

Science.gov (United States)

By Nathalie Walker, Guest Writer Editor’s note: This article is the second in a series describing one student’s perspective on her experiences as a Werner H. Kirsten student intern. “The future depends on what you do today.” Those wise words were spoken by Mahatma Gandhi. Before I started my Werner H. Kirsten (WHK) student internship, I did not know what I know now. I only

Spatial Displays and Spatial Instruments

Science.gov (United States)

1989-01-01

assistance and to Evi Fricke, Werner Haustein , Werner Mohren, Stephen R. Ellis, and Heiner Deubel for their valuable contributions to...by Harris et al. (1979) at the Mayo Clinic and Herman et al. (1984) at the University of Pennsylvania in the area of medical imaging. In 1983, Jaffey...graphics techniques for interactive visualization of data based on surface representations. The groundwork for this was done by Herman et al. Work

Heisenberg lecture: Supersymmetry in the spectra of atomic nuclei

International Nuclear Information System (INIS)

Graw, Gerhard

2003-01-01

Talk given at the Symposium: 'Werner Heisenberg und die Wissenschaft, das Denken und die Kunst', Alexander von Humboldt Club, Bucharest, October 16 - 17, 2001, Goethe-Institut, Bucharest, Romania. This Symposium of the Humboldt Club in Bucharest was dedicated to the work of Werner Heisenberg. With the occasion of the hundredth anniversary of his birthday the aim was to recall the impact of Heisenberg's work not only on physics and related fields but also on philosophy and on our present understanding of science. Werner Heisenberg discovered and formulated the laws of quantum physics, the concepts and the tools one uses at present. These discoveries resulted from his ambitious goal to reveal the fundamental laws of physics and to understand these laws within the logical and structural aspects they imply for the understanding of nature and of thinking. In this way he was aware of the potential of this fundamental new approach and applied the concept of quantum phenomena to physics, chemistry, biology, and to logical-philosophical questions. Being invited here as first speaker of this Symposium the author considered as appropriate, first to recall a few dates out of his vita and essentials of his work, and then to address to a timely subject, which is, hopefully, related to the work of Werner Heisenberg. (author)

Recharge and discharge of near-surface groundwater in Forsmark. Comparison of classification methods

International Nuclear Information System (INIS)

Werner, Kent; Johansson, Per-Olof; Brydsten, Lars; Bosson, Emma; Berglund, Sten

2007-03-01

This report presents and compares data and models for identification of near-surface groundwater recharge and discharge (RD) areas in Forsmark. The general principles of groundwater recharge and discharge are demonstrated and applied to interpret hydrological and hydrogeological observations made in the Forsmark area. 'Continuous' RD classification methods considered in the study include topographical modelling, map overlays, and hydrological-hydrogeological flow modelling. 'Discrete' (point) methods include field-based and hydrochemistry-based RD classifications of groundwater monitoring well locations. The topographical RD modelling uses the digital elevation model as the only input. The map overlays use background maps of Quaternary deposits, soils, and ground- and field layers of the vegetation/land use map. Further, the hydrological-hydrogeological modelling is performed using the MIKE SHE-MIKE 11 software packages, taking into account e.g. topography, meteorology, hydrogeology, and geometry of watercourses and lakes. The best between-model agreement is found for the topography-based model and the MIKE SHE-MIKE 11 model. The agreement between the topographical model and the map overlays is less good. The agreement between the map overlays on the one hand, and the MIKE SHE and field-based RD classifications on the other, is thought to be less good, as inferred from the comparison made with the topography-based model. However, much improvement of the map overlays can likely be obtained, e.g. by using 'weights' and calibration (such exercises were outside the scope of the present study). For field-classified 'recharge wells', there is a good agreement to the hydrochemistry-based (Piper plot) well classification, but less good for the field-classified 'discharge wells'. In addition, the concentration of the age-dating parameter tritium shows low variability among recharge wells, but a large spread among discharge wells. The usefulness of hydrochemistry-based RD

Obituary: Michael John Klein, 1940-2005

Science.gov (United States)

Gulkis, Samuel

2006-12-01

Michael John Klein died on 14 May 2005 at home in South Pasadena, California. The cause of death was tongue cancer that metastasized to the lungs. He was a non-smoker. Mike was a passionate radio astronomer, a trusted astronomical observer, an educator and a family man. Mike was born on 19 January 1940 in Ames, Iowa, the son of Florence Marie (Graf) and Fred Michael Klein. His mother was a homemaker, and his father was a banker. Mike had two older sisters, Lois Jean (Klein) Flauher and Marilyn June (Klein) Griffin. In 1962, Mike married his high school sweetheart Barbara Dahlberg, who survives him along with their three children, Kristin Marie (Klein) Shields, Michael John Klein Jr., Timothy Joel Klein, and six grandchildren. Mike developed a love for astronomy early in his life, and credited an early morning, newspaper-delivery route that he had at age twelve, which took him outside well before sunrise. He told family members that as he walked along his route, he stared into the sky and wondered what everything was. He studied sky charts, located stars, and began to understand how the planets shifted their positions relative to the stars each day. Another big influence in Mike's life was his brother in-law, Jim Griffin. Jim helped Mike understand that his passion for science did not have to remain a hobby, but could and should become a career. Jim's encouragement led Mike to attend Iowa State University in Ames, where he earned a BS in electrical engineering in 1962. Mike then started graduate school in electrical engineering at Michigan State, but after one semester transferred to the University of Michigan, Ann Arbor, where he earned an MS (1966) and PhD (1968) in astronomy. His doctoral dissertation, under the direction of Professor Fred Haddock, was based on extensive observations of the planets and examined the physical and thermal properties of planetary atmospheres and surfaces. Mike was awarded a Resident Research Associate position at JPL by the National

VizieR Online Data Catalog: Boo-127 and Boo-980 high-resolution spectra (Frebel+, 2016)

Science.gov (United States)

Frebel, A.; Norris, J. E.; Gilmore, G.; Wyse, R. F. G.

2016-09-01

We observed Boo-980 and Boo-127 stars with the MIKE spectrograph on the Magellan-Clay telescope in 2010 March and 2011 March. Details of the MIKE observations and photometry taken from Norris et al. (2008ApJ...689L.113N) are given in Table 1. MIKE spectra have nearly full optical wavelength coverage over the range ~3500-9000Å (R~22000 in the red and ~28000 in the blue wavelength regime). (2 data files).

Symbol Formation Reconsidered

DEFF Research Database (Denmark)

Wagoner, Brady

2013-01-01

them vis-à-vis other research at Clark and in American psychology more generally. The second two articles analyse Werner and Kaplan’s notions of ‘distancing’ and ‘physiognomic metaphor’, showing their roots in naturphilosophie and comparing them with contemporary theories. The last four articles apply......Werner and Kaplan’s Symbol formation was published 50 years ago but its insights have yet to be adequately explored by psychology and other social sciences. This special issue aims to revisit this seminal work in search of concepts to work on key issues facing us today. This introductory article...... begins with a brief outline and contextualization of the book as well as of the articles that this special issue comprises. The first two articles were written by contributors who were part of the Werner era at Clark University. They explore the key concepts of the organismic and development, and situate...

Recharge and discharge of near-surface groundwater in Forsmark. Comparison of classification methods

Energy Technology Data Exchange (ETDEWEB)

Werner, Kent [Golder Associates AB, Uppsala (Sweden); Johansson, Per-Olof [Artesia Grundvattenkonsult AB, Taeby (Sweden); Brydsten, Lars [Umeaa University, Dept. of Ecology and Environmental Science (Sweden); Bosson, Emma; Berglund, Sten [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden)

2007-03-15

This report presents and compares data and models for identification of near-surface groundwater recharge and discharge (RD) areas in Forsmark. The general principles of groundwater recharge and discharge are demonstrated and applied to interpret hydrological and hydrogeological observations made in the Forsmark area. 'Continuous' RD classification methods considered in the study include topographical modelling, map overlays, and hydrological-hydrogeological flow modelling. 'Discrete' (point) methods include field-based and hydrochemistry-based RD classifications of groundwater monitoring well locations. The topographical RD modelling uses the digital elevation model as the only input. The map overlays use background maps of Quaternary deposits, soils, and ground- and field layers of the vegetation/land use map. Further, the hydrological-hydrogeological modelling is performed using the MIKE SHE-MIKE 11 software packages, taking into account e.g. topography, meteorology, hydrogeology, and geometry of watercourses and lakes. The best between-model agreement is found for the topography-based model and the MIKE SHE-MIKE 11 model. The agreement between the topographical model and the map overlays is less good. The agreement between the map overlays on the one hand, and the MIKE SHE and field-based RD classifications on the other, is thought to be less good, as inferred from the comparison made with the topography-based model. However, much improvement of the map overlays can likely be obtained, e.g. by using 'weights' and calibration (such exercises were outside the scope of the present study). For field-classified 'recharge wells', there is a good agreement to the hydrochemistry-based (Piper plot) well classification, but less good for the field-classified 'discharge wells'. In addition, the concentration of the age-dating parameter tritium shows low variability among recharge wells, but a large spread among discharge

Original meaning of the notion and term “formation” in geology

Directory of Open Access Journals (Sweden)

Grubić Aleksandar

2014-01-01

Full Text Available The notion of (geological formation has gradually developed through mostly German terms: from ein Gebirge, which was used by Saxon miners for several centuries (AGRICOLA, then Schichten, Bergart (LEHMANN and serie montana (FUCHSEL to Gebirgsart (WERNER. The term ‘formation’ was introduced by WERNER in 1791 and its meaning was clearly defined around 1800. He included the notion of “formation” into his system of “geognostic structures”: mineral; rock (layer; formation; Earth’s crust. Therefore, it was an equivocal term from the start. It implied a geological body of certain composition, genesis and superposition (i.e. time of origination. After Werner, the term ‘formation’ was used in different ways, mostly as a synonym for a ‘system’, until 1881 when such use was forbidden. The original Wernerian sense of the term ‘formation’ (as a unit in geological levels of organisation: mineral-rock-formation-geosphere-planet with an intentionally equivocal meaning was not restored until the second half of the twentieth century.

Dynamics and Stochastics Festschrift Keane (Michael S) on the occasion of his 65th birthday on 2 Jan 2005

CERN Document Server

Denteneer, Dee; Verbitskiy, Evgeny

2006-01-01

Contains 29 contributions by Mike's closest colleagues and friends, covering a broad range of topics in Dynamics and Stochastics. - To celebrate Mike's scientific achievements, a conference entitled "Dynamical Systems, Probability Theory and Statistical Mechanics" was organized in Eindhoven, The Netherlands, during the week of January 3-7, 2005. This conference was hosted jointly by EURANDOM and by Philips Research. It drew over 80 participants from 5 continents, which is a sign of the warm affection and high esteem for Mike felt by the international mathematics community.

Paradiis 2.0 / Laurie Werner

Index Scriptorium Estoniae

Werner, Laurie

2014-01-01

Oracle'i tegevjuht Larry Ellison ostis 98% Hawai saarest Lanaist. Ettevõtja soovib rajada sinna tööstuspiirkondada, võtta kasutusele päikeseenergiarajatisi, tuua saarele elektriautosid ja suurendada elanikkonda

Genetics Home Reference: Werner syndrome

Science.gov (United States)

... 2 [updated 2016 Sep 29]. In: Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Ledbetter N, Mefford HC, Smith RJH, Stephens K, editors. GeneReviews® [Internet]. Seattle (WA): ...

Computational Identification and Analysis of Signaling Subnetworks with Distinct Functional Roles in the Regulation of TNF Production

Science.gov (United States)

2016-01-04

extract four distinct quantitative features of response timing and intensity: the trajectory peak height, the peak time, the area under the curve, and...J., 2007, 21, 325–332. 16 S. L. Werner, J. D. Kearns, V. Zadorozhnaya, C. Lynch, E. O’Dea, M. P. Boldin , A. Ma, D. Baltimore and A. Hoffmann, Genes...Werner, J. D. Kearns, V. Zadorozhnaya, C. Lynch, E. O’Dea, M. P. Boldin , A. Ma, D. Baltimore and A. Hoffmann, Genes Dev., 2008, 22, 2093–2101. 58 J

DOD Product Support Business Case Analysis Guidebook

Science.gov (United States)

2011-04-01

Cargo Aircraft; Mike Tesi , 256-313-3745 10 Automatic Requirements Computation System Initial Provisioning (ARCSIP) CECOM; Ken Steinberg, LEO...Block III 256-313- 4988 PM Aviation Systems, PD Joint Cargo Aircraft Mike Tesi , 256- 313-3745 16 Computerized Optimization Model for

[Two traditions in the scientific learning of the world. A case study of creation and reception of quantum mechanics over the period 1925-1927, on the bases of discussion between Werner Heisenberg and Albert Einstein].

Science.gov (United States)

Krajniak, Wiktor

2014-01-01

The purpose of this article is the analyses of discussion between Albert Einstein and Werner Heisenberg in the period 1925-1927. Their disputes, relating to the sources of scientific knowledge, its methods and the value of knowledge acquired in this way, are part of the characteristic for the European science discourse between rationalism and empirism. On the basis of some sources and literature on the subject, the epistemological positions of both scholars in the period were reconstructed. This episode, yet poorly known, is a unique example of scientific disputes, whose range covers a broad spectrum of methodological problems associated with the historical development of science. The conducted analysis sheds some light on the source of popularity of logical empirism in the first half of the 20th century. A particular emphasis is placed on the impact of the neopositivist ideas which reflect Heisenberg's research program, being the starting point for the Copenhagen interpretation of quantum mechanics. The main assumption of logical empirism, concerning acquisition of scientific knowledge only by means of empirical procedures and logical analysis of the language of science, in view of the voiced by Einstein arguments, bears little relationship with actual testing practices in the historical aspect of the development of science. The criticism of Heisenberg's program, carried out by Einstein, provided arguments for the main critics of the neopositivist ideal and contributed to the bankruptcy of the idea of logical empirism, thereby starting a period of critical rationalism prosperity, arising from criticism of neopositivism and alluding to Einstein's ideas.

Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops

DEFF Research Database (Denmark)

Kusumoto-Matsuo, Rika; Opresko, Patricia L; Ramsden, Dale

2010-01-01

Werner syndrome is an inherited human progeriod syndrome caused by mutations in the gene encoding the Werner Syndrome protein, WRN. It has both 3'-5' DNA helicase and exonuclease activities, and is suggested to have roles in many aspects of DNA metabolism, including DNA repair and telomere...... D-loop model substrate. In addition, the length of telomeric G-tails decreases in DNA-PKcs knockdown cells, and this phenotype is reversed by overexpression of WRN helicase. These results suggest that WRN and DNA-PKcs may cooperatively prevent G-tail shortening in vivo....

Use of remote sensing data in distributed hydrological models: applications in the Senegal River basin

DEFF Research Database (Denmark)

Sandholt, Inge; Andersen, Jens Asger; Gybkjær, Gorm

1999-01-01

Earth observation, remote sensing, hydrology, distributed hydrological modelling, West Africa, Senegal river basin, land cover, soil moisture, NOAA AVHRR, SPOT, Mike-she......Earth observation, remote sensing, hydrology, distributed hydrological modelling, West Africa, Senegal river basin, land cover, soil moisture, NOAA AVHRR, SPOT, Mike-she...

U.S. Naval Research Laboratory Final Analysis Report to NATO Above Water Warfare Capabilities Group 2016 Naval Electromagnetic Operations Trials

Science.gov (United States)

2017-05-23

SUPPLEMENTARY NOTES 14. ABSTRACT 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: a. REPORT 19a. NAME OF RESPONSIBLE PERSON 19b. TELEPHONE NUMBER (include...4.2. Description of IOTA -MIKE Unmanned Aircraft System (UAS) Simulator ....................... 7 4.3. Description of CAWS...14 6.4. IOTA -MIKE

Integrated Modeling System for Analysis of Watershed Water Balance: A Case Study in the Tims Branch Watershed, South Carolina

Science.gov (United States)

Setegn, S. G.; Mahmoudi, M.; Lawrence, A.; Duque, N.

2015-12-01

The Applied Research Center at Florida International University (ARC-FIU) is supporting the soil and groundwater remediation efforts of the U.S. Department of Energy (DOE) Savannah River Site (SRS) by developing a surface water model to simulate the hydrology and the fate and transport of contaminants and sediment in the Tims Branch watershed. Hydrological models are useful tool in water and land resource development and decision-making for watershed management. Moreover, simulation of hydrological processes improves understanding of the environmental dynamics and helps to manage and protect water resources and the environment. MIKE SHE, an advanced integrated modeling system is used to simulate the hydrological processes of the Tim Branch watershed with the objective of developing an integrated modeling system to improve understanding of the physical, chemical and biological processes within the Tims Branch watershed. MIKE SHE simulates water flow in the entire land based phase of the hydrological cycle from rainfall to river flow, via various flow processes such as, overland flow, infiltration, evapotranspiration, and groundwater flow. In this study a MIKE SHE model is developed and applied to the Tim branch watershed to study the watershed response to storm events and understand the water balance of the watershed under different climatic and catchment characteristics. The preliminary result of the integrated model indicated that variation in the depth of overland flow highly depend on the amount and distribution of rainfall in the watershed. The ultimate goal of this project is to couple the MIKE SHE and MIKE 11 models to integrate the hydrological component in the land phase of hydrological cycle and stream flow process. The coupled MIKE SHE/MIKE 11 model will further be integrated with an Ecolab module to represent a range of water quality, contaminant transport, and ecological processes with respect to the stream, surface water and groundwater in the Tims

The Navy Supply Corps Newsletter. Contracting Innovations: Navy Electronic Commerce Online Navy Afloat Purchase Card Program. Volume 62, No. 3.

Science.gov (United States)

1998-06-01

Mike Lyden John Lantelme Andy Mackel Jesus Malgapo Carol Marcinek Greg Martin Michelle McAtee Molly McClellan Jerry McEnerney Laurie McKee...Paul McNeill Walt Melton Rich Mendez Mike Metts Jon Miller Ron Mosley Jim Naber Craig Nostrant NAVSUP USSNORMANDY(CG60) DDRE NORFOLK NPGS

Kuala Kemaman hydraulic model study

International Nuclear Information System (INIS)

Abdul Kadir Ishak

2005-01-01

There The problems facing the area of Kuala Kemaman are siltation and erosion at shoreline. The objectives of study are to assess the best alignment of the groyne alignment, to ascertain the most stable shoreline regime and to investigate structural measures to overcome the erosion. The scope of study are data collection, wave analysis, hydrodynamic simulation and sediment transport simulation. Numerical models MIKE 21 are used - MIKE 21 NSW, for wind-wave model, which describes the growth, decay and transformation of wind-generated waves and swell in nearshore areas. The study takes into account effects of refraction and shoaling due to varying depth, energy dissipation due to bottom friction and wave breaking, MIKE 21 HD - modelling system for 2D free-surface flow which to stimulate the hydraulics phenomena in estuaries, coastal areas and seas. Predicted tidal elevation and waves (radiation stresses) are considered into study while wind is not considered. MIKE 21 ST - the system that calculates the rates of non-cohesive (sand) sediment transport for both pure content and combined waves and current situation

Uncovering activity cliff generators using distribution of SALI values

Directory of Open Access Journals (Sweden)

José L. Medina-Franco

2018-01-01

Full Text Available Los acantilados de actividad se definen como compuestos con alta similitud estructural, pero también con altadiferencia en potencia. Estos compuestos tienen un impacto significativo en la optimización de líderes en químicamedicinal y en aplicaciones computacionales, como el desarrollo de modelos predictivos y en la selección demoléculas de referencia en búsquedas basadas en similitud molecular. Por lo tanto, es de gran relevancia laidentificación de compuestos altamente asociados con los acantilados como por ejemplo los “generadores deacantilados de actividad”. En este trabajo se reportan la identificación de acantilados de actividad y las relacionesestructura-actividad de un grupo de 289 compuestos obtenidos por síntesis química que han sido evaluados a travésde una proteína quinasa reguladora de receptores acoplados a proteínas-G. Para considerar la información demúltiples representaciones estructurales, se empleó el promedio del índice SALI (Structure-Activity Landscape Indexy se discuten también fragmentos estructurales responsables de la actividad biológica.

Pierce - University of Georgia | Division of Cancer Prevention

Science.gov (United States)

Principal Investigator: J. Michael Pierce, PhDInstitution: University of Georgia, Athens, GA Our project, Discovery and Development of Cancer Glycomarkers, is a joint collaboration between our laboratories at the CCRC, which include Karen Abbott, Lance Wells, Kevin Dobbin, and Mike Tiemeyer, those at TGen, in Phoenix, AZ, Daniel Von Hoff, Haiyong Han, and Mike Demeure, and

Sensitivity of stream flow and water table depth to potential climatic variability in a coastal forested watershed

Science.gov (United States)

Zhaohua Dai; Carl Trettin; Changsheng Li; Devendra M. Amatya; Ge Sun; Harbin Li

2010-01-01

A physically based distributed hydrological model, MIKE SHE, was used to evaluate the effects of altered temperature and precipitation regimes on the streamflow and water table in a forested watershed on the southeastern Atlantic coastal plain. The model calibration and validation against both streamflow and water table depth showed that the MIKE SHE was applicable for...

Gasellid ja kilpkonnad / Hans-Werner Sinn

Index Scriptorium Estoniae

Sinn, Hans-Werner, 1948-

2010-01-01

Müncheni ülikooli professori sõnul on maailm praegu jagunenud kaheks riikide rühmaks - üks on teel jõulise taastumise poole, teine annab märku uutest probleemidest. Esimesse kuuluvad Brasiilia, Venemaa, India ja Hiina, teises rühmas on võlaprobleemidega riigid eesotsas USA-ga. Euroopa riikidest

Integrated surface-subsurface water flow modelling of the Laxemar area. Application of the hydrological model ECOFLOW

International Nuclear Information System (INIS)

Sokrut, Nikolay; Werner, Kent; Holmen, Johan

2007-01-01

Since 2002, the Swedish Nuclear Fuel and Waste Management Co (SKB) performs site investigations in the Simpevarp area, for the siting of a deep geological repository for spent nuclear fuel. The site descriptive modelling includes conceptual and quantitative modelling of surface-subsurface water interactions, which are key inputs to safety assessment and environmental impact assessment. Such modelling is important also for planning of continued site investigations. In this report, the distributed hydrological model ECOFLOW is applied to the Laxemar subarea to test the ability of the model to simulate surface water and near-surface groundwater flow, and to illustrate ECOFLOW's advantages and drawbacks. The ECOFLOW model area is generally characterised by large areas of exposed or shallow bedrock. The ECOFLOW modelling results are compared to previous results produced by MIKE SHE-MIKE 11 and PCRaster-POLFLOW, in order to check whether non-calibrated surface and subsurface water flows computed by ECOFLOW are consistent with these previous results. The analyses include quantification and comparison of inflow and outflow terms of the water balance, as well as analyses of groundwater recharge-discharge patterns. ECOFLOW is used to simulate a one-year non calibrated period, considering seven catchments (including three areas with direct runoff to the sea) within the Laxemar subarea. The modelling results show the ability of the model to produce reasonable results for a model domain including both porous media (Quaternary deposits) and discontinuous media (bedrock). The results demonstrate notable differences in the specific discharge between the considered catchments, with specific discharge values in the range 157-212 mm/year; the lowest value (the Lake Frisksjoen catchment) may however be erroneous due to numerical instability in the model. Overall, these results agree with specific discharge values computed by MIKE SHE-MIKE 11 and PCRaster-POLFLOW (190 and 128-186 mm

Integrated surface-subsurface water flow modelling of the Laxemar area. Application of the hydrological model ECOFLOW

Energy Technology Data Exchange (ETDEWEB)

Sokrut, Nikolay; Werner, Kent; Holmen, Johan [Golder Associates AB, Uppsala (Sweden)

2007-01-15

Since 2002, the Swedish Nuclear Fuel and Waste Management Co (SKB) performs site investigations in the Simpevarp area, for the siting of a deep geological repository for spent nuclear fuel. The site descriptive modelling includes conceptual and quantitative modelling of surface-subsurface water interactions, which are key inputs to safety assessment and environmental impact assessment. Such modelling is important also for planning of continued site investigations. In this report, the distributed hydrological model ECOFLOW is applied to the Laxemar subarea to test the ability of the model to simulate surface water and near-surface groundwater flow, and to illustrate ECOFLOW's advantages and drawbacks. The ECOFLOW model area is generally characterised by large areas of exposed or shallow bedrock. The ECOFLOW modelling results are compared to previous results produced by MIKE SHE-MIKE 11 and PCRaster-POLFLOW, in order to check whether non-calibrated surface and subsurface water flows computed by ECOFLOW are consistent with these previous results. The analyses include quantification and comparison of inflow and outflow terms of the water balance, as well as analyses of groundwater recharge-discharge patterns. ECOFLOW is used to simulate a one-year non calibrated period, considering seven catchments (including three areas with direct runoff to the sea) within the Laxemar subarea. The modelling results show the ability of the model to produce reasonable results for a model domain including both porous media (Quaternary deposits) and discontinuous media (bedrock). The results demonstrate notable differences in the specific discharge between the considered catchments, with specific discharge values in the range 157-212 mm/year; the lowest value (the Lake Frisksjoen catchment) may however be erroneous due to numerical instability in the model. Overall, these results agree with specific discharge values computed by MIKE SHE-MIKE 11 and PCRaster-POLFLOW (190 and 128

Agile-Lean Software Engineering (ALSE) Evaluating Kanban in Systems Engineering

Science.gov (United States)

2013-03-06

David Anderson (David J. Anderson and Associates)  Jabe Bloom (The Library Corporation)  Mike Burrows (David J. Anderson and Associates)  Ian...Dominic Lepore (Stevens Institute, Howe School)  Larry Maccherone (Rally Software)  Don Reinertsen (Reinertsen & Associates)  David Rico...ongoing, continuous integration also approximate the effect of small batch sizes. For a different approach to describing kanban, see Mike Burrows

VIRSU kevadseminar / Merike Määrits

Index Scriptorium Estoniae

Määrits, Merike

2000-01-01

Tallinna Pedagoogikaülikooli läänemeresoome keelte õppetool korraldas 25.-26.02.2000 1998.a. käivitunud VIRSU-projekti "Emakeele mõju soome ja eesti keele õppimisele ja õpetamisele" III kevadseminari. Projektis osalevad Oulu ja Joensuu Ülikool Soomest ning Tallinna Pedagoogikaülikool ja Tartu Ülikool Eestist. Üldkoordinaator on Pirkko Muikku-Werner Joensuu Ülikoolist, TPÜd esindab professor Jaan Õispuu. Kevadseminaril esinesid H. Laanekask (Oulu Ülikool), A. Kataja (TÜ), L. Nissila (Oulu Ülikool), J. Õispuu (TPÜ), N. Happonen (TÜ), J. Valge (TÜ), A. Kaivapalu (TPÜ), P. Muikku-Werner (Joensuu Ülikool), H. Sooväli (TPÜ-TÜ), H. Remes (Joensuu Ülikool), I. Nikopensius (TÜ)

Entanglement Evolution of Three-Qubit States under Local Decoherence

International Nuclear Information System (INIS)

Ma Xiaosan; Liu Gaosheng; Wang Anmin

2010-01-01

By using negativity as entanglement measure, we have investigated the effect of local decoherence from a non-Markovian environment on the time evolution of entanglement of three-qubit states including the GHZ state, the W state, and the Werner state. From the results, we find that the entanglement dynamics depends not only on the coupling strengths but also on the specific states of concern. Specifically, the entanglement takes different behaviors under weak or strong coupling and it varies with the quantum states under study. The entanglement of the GHZ state and the Werner state can be destroyed completely by the local decoherence, while the entanglement of the W state can survive through the local decoherence partially. (general)

Laboratory Services Guide

Science.gov (United States)

1994-10-01

Division Chief Dr George Lee ................................ Executive Manager MSgt Mike Wantland .. . . . . . . . . . . . . . .Division...prevents cross contamination of samples. The plastic bag may be Labelled with either a Sharple or an adhesive-backed label. Finally, the bagged tube...cost of the TCLP Metals Screen is aruund $400.00. 3. Who do I call ff I have Further questions? In the Analytical Division, MSgt Mike Wantland (DSN240

2011 Information Systems Summit 2

Science.gov (United States)

2011-04-06

SECURE AGILE DEVELOPMENT · Mr. Jeff Payne, CEO and Founder, Coveros, Inc. LEAN AND KANBAN · Mr. Mike Cox, Senior Consultant, Net...Maryland Suite: Annapolis LEAN AND KANBAN Mr. Mike Cox, Senior Consultant, Net Objectives TRACK B Maryland Suite: Baltimore 4:15 pm - 5:15 pm THANK...Innovation to Transform Army Intel 14 Agile © copyright 2011. Net Objectives, Inc. Lean and Kanban Michael Cox Vice President and Senior

2011 Information Systems Summit 2 Held in Baltimore, Maryland on April 4-6, 2011

Science.gov (United States)

2011-04-04

SECURE AGILE DEVELOPMENT · Mr. Jeff Payne, CEO and Founder, Coveros, Inc. LEAN AND KANBAN · Mr. Mike Cox, Senior Consultant, Net...Maryland Suite: Annapolis LEAN AND KANBAN Mr. Mike Cox, Senior Consultant, Net Objectives TRACK B Maryland Suite: Baltimore 4:15 pm - 5:15 pm THANK...Innovation to Transform Army Intel 14 Agile © copyright 2011. Net Objectives, Inc. Lean and Kanban Michael Cox Vice President and Senior

Report of the Information Technology Workshop

Science.gov (United States)

1983-10-01

computer sci- ence and related fields. Th-se demographics result in 8.0 PRIORITIES sharpl ) increased demand for both faculty and technologi- The problem...Universities scripts for NL representation. The following universities are active in NL: Columbia University ( Mike Lebowitz. Cathy McKeown) Yale (Roger...Bruce beat environment for NL research; anything less will mean Buchanan, Mike Genesreth. The Heuristic Program- that progress is slower than it could

Book Review: Adolf Hitler. Legende, mythe, werkelijkheid | Ploeger ...

African Journals Online (AJOL)

Abstract. Book Title: Adolf Hitler. Legende, mythe, werkelijkheid. Book Author: Werner Maser. Uitgeverij De Arbeiderspers, Amsterdam, 1973, pp. 531. Met aantekeninge [pp. 429 - 506] en bibliografie [pp. 507 - 531].

Hierarchical Models of the Nearshore Complex System

National Research Council Canada - National Science Library

Werner, Brad

2004-01-01

.... This grant was termination funding for the Werner group, specifically aimed at finishing up and publishing research related to synoptic imaging of near shore bathymetry, testing models for beach cusp...

In Contact! Case Studies from the Long War. Volume I

Science.gov (United States)

2006-01-01

lull, Bellavia called his platoon sergeant, Cantrell, on his radio. Cantrell, who was not with Meno, immediately responded yelling into the mike ...at <http://www.infoplease.com/ipa/A0107644.html>, accessed 12 June 2006. 3. Mike Tucker, Among Warriors in Iraq: True Grit, Special Ops, and...SGT Kennedy SPC Detman SPC Hubbard SPC Graff SPC Harris SPC Rullo SPC Kinzer SPC Sharples SPC Heesacker SPC Birkel SPC Schrad Regulator 3 SSG Castro SPC

Computing Science and Statistics. Volume 24. Graphics and Visualization

Science.gov (United States)

1993-03-01

Mike West Institute of Statistics & Decision Sciences Duke University, Durham NC 27708, USA Abstract density estimation techniques. With an importance...in J., Sharples , L. D. and Kirby, A. J. press). (1992b) Modelling complexity: applica- Wakefield J. C., Smith, A. F. M., Racine- tions of Gibbs...Math & Stats Box 13040 SFA Riccarton Edinburgh, Scotland EH 14 4AS Nacognoches, TX 75962 mike @cara.ma.hw.ac.uk Allen McIntosh Michael T. Longnecker

Annual National Logistics Conference and Exhibition (26th) (BRIEFING CHARTS)

Science.gov (United States)

2010-04-15

Operations Division, Office of the Chief of Naval Operations (OPNAV N41) Luncheon Speaker · BrigGen Mike Dana , USMC, Director of Logistics...Speaker u BrigGen Mike Dana , USMC, Director of Logistics & Engineering, J4, NORAD and USNORTHCOM u Col Alex Vohr, USMC, Director of Logistics, J4...are the Core Elements of a Curriculum on Contemporary Strategy, and What are the Best Methods of Teaching Them? Dr Richard Betts, Arnold A. Saltzman

National Test and Evaluation Conference (26th)

Science.gov (United States)

2010-03-04

Operations Division, Office of the Chief of Naval Operations (OPNAV N41) Luncheon Speaker · BrigGen Mike Dana , USMC, Director of Logistics...Speaker u BrigGen Mike Dana , USMC, Director of Logistics & Engineering, J4, NORAD and USNORTHCOM u Col Alex Vohr, USMC, Director of Logistics, J4...are the Core Elements of a Curriculum on Contemporary Strategy, and What are the Best Methods of Teaching Them? Dr Richard Betts, Arnold A. Saltzman

Polanski jälgib koduarestist oma filmi melu Berlinalel / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

2010-01-01

11.-21. veebruaril 2010. toimuval Berliini filmifestivalil Berlinale esilinastub Roman Polanski film "The Ghost Writer" (Prantsusmaa- Saksamaa-Suurbritannia, 2010). Võistlusprogrammis on 20 filmi 18 maalt, žüriid juhib Werner Herzog

WHK Student Interns Named Top Scholars in Regeneron Science Talent Search | Poster

Science.gov (United States)

Two Werner H. Kirsten Student Interns were recently named Top Scholars in the 2017 Regeneron Science Talent Search, the nation’s most prestigious science and math competition for high school students.

Saksa minister: finantsturud tahavad eurot hävitada / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2011-01-01

Saksamaa asevälisminister Werner Hoyer ütleb, et rahvusvahelistel finantsturgudel ei ole mingit huvi näha eurot ega ka Euroopat edukana. Tema hinnangul peitub võti senisest kursist rangelt kinnihoidmises

New arrivals

CERN Document Server

2003-01-01

On Monday 22 September, members of CERN Management welcomed recently-recruited staff members and fellows at the trimester session of the Induction Programme (photographed here with Werner Zapf, Human Resources Division Leader).

CERN's new arrivals, September 2003

CERN Document Server

Maximilien Brice

2003-01-01

On Monday 22 September, members of CERN Management welcomed recently-recruited staff members and fellows at the trimester session of the Induction Programme (photographed here with Werner Zapf, Human Resources Division Leader)

Quo Vadis, kaubandushiid Hyperlex? / Mike Franz Wahl

Index Scriptorium Estoniae

Wahl, Mike Franz, 1966-

2007-01-01

Juhtimiskaasuste võistluse "Juhtimisaju 2007" raames tuli osalejatel lahendada juhtum seoses ettevõtete liitumisega. Vt. samas näited võistlustöödest: Vanaviisi ei saa, uutmoodi ei taha...; Inimesed, rääkige!. Juhtimisaju 2007 parimad võistkonnad

Reply to Comment on ‘What Bell did’

International Nuclear Information System (INIS)

Maudlin, Tim W

2014-01-01

First, let me express my appreciation to Professor Werner for his discussion of my paper. These are quite contentious and fiercely disputed questions, and the only way to make progress in resolving these disputes is to make a good faith effort to present the arguments clearly and explicitly. Only once things are pinned down on paper with some precision can a proper analysis proceed. Werner’s willingness to do this means progress can be made. There are some important points on which Werner and I agree. We agree that neither Einstein nor Bell presuppose determinism in framing their arguments, so the conclusions of those arguments cannot be avoided simply by adopting indeterminism. We even largely agree on what Bell thought he proved. For example, we agree that Bell did not take his theorem to refute determinism or ‘hidden variables’. Werner even seems to concede that Bell himself thought that he had proven the necessity for any theory that reproduces the predictions of the quantum formalism—or more generally any theory that predicts violations of his inequality for pairs of experiments done at space-like separation—to be non-local (in a particular sense of ‘non-local’). Agreement on this much is already a tremendous amount of progress, and I do not wish to undervalue it

Sakslaste stiliseeritud hullus / Erkki Luuk

Index Scriptorium Estoniae

Luuk, Erkki, 1971-

2004-01-01

PÖFFi Suvekino prorgramm "Oberhauseni lapsed" saksa 1960-1970. aastate uuenduslikest mängufilmidest : Alexander Kluge "Artistid tsirkusekupli all : lootusetus", Rainer Werner Fassbinderi "13 kuud aastas", Wim Wendersi "Valeliigutus" ja "Ameerika sõber"

Eestlaste abil valminud 3D-film linastus Torontos

Index Scriptorium Estoniae

2010-01-01

Režissöör Werner Herzogi täispikka 3D-dokumentaalfilmi "Cave of Forgotten Dreams" (Saksamaa 2010) aitas filmida ja kokku monteerida Eesti firma Digitaalne Sputnik eesotsas videokunstnik Kaspar Kallasega

Computing Science and Statistics: Volume 24. Graphics and Visualization

Science.gov (United States)

1993-03-20

Models Mike West Institute of Statistics & Decision Sciences Duke University, Durham NC 27708, USA Abstract density estimation techniques. With an...ratio-of-uniforms halter, D. J., Best, N. G., McNeil, A. method. Statistics and Computing, 1, (in J., Sharples , L. D. and Kirby, A. J. press). (1992b...Dept of Act. Math & Stats Box 13040 SFA Riccarton Edinburgh, Scotland EH 14 4AS Nacognoches, TX 75962 mike @cara.ma.hw.ac.uk Allen McIntosh Michael T

Iroquois Warriors in Iraq

Science.gov (United States)

2007-01-01

Morales met with COL Mike Milano, the CFLCC C3. Milano provided Morales with the basic details he needed to develop the division RSOI plan. Milano...MOI.23 The 98th Division contributed 28 soldiers to the CPATT staff, to include COL Michael R. “ Mike ” Smith, who was assigned as the chief of staff...Institute, Fort Leavenworth, KS. Attachment: E-mail, COL Charles Stafford to LTC Keith Sharples , Subject: New Guy Stuff, 25 August 2004. ________. E

Werner Heisenberg. A traveller between two worlds

International Nuclear Information System (INIS)

Fischer, Ernst Peter

2015-01-01

The following topics are dealt with: A night in Helgoland, no quietude ever, smart quantum jumps, three teachers and their pupil, life with two worlds, a young professor, the Nobel prize and the time of the Nazis, the atomic nucleus and its energy, finally to Munich, steps over boundaries. (HSI)

Kasutatud auto ost pangalt / Hans-Werner Sinn

Index Scriptorium Estoniae

Sinn, Hans-Werner, 1948-

2008-01-01

Praegune halbade hüpoteeklaenude kriis on neljas ja suurim panganduskriis alates II Maailmasõjast. Mahakantud summa ulatub triljonile dollarile, millest lõviosa kannavad ilmselt USA finantsinstitutsioonid

Kristjan Järvi juhatab Pärdi maailmaesiettekannet Viinis / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2008-01-01

Arvo Pärdi teose "Stabat Mater" segakoori- ja keelpilliorkestriversiooni maailmaesiettekandest 12. juunil Viinis ja dirigent Kristjan Järvi tegemistest. Bariton Lauri Vasar laulmas Hans Werner Henze ooperis "Phaedra" Berliinis, Brüsselis ja Viinis

Heisenberg vortex for light-weight refrigeration of liquid hydrogen

Data.gov (United States)

National Aeronautics and Space Administration — Only 83 years ago Werner Karl Heisenberg was awarded the Nobel Prize in physics. His work led to the creation of quantum mechanics, the application of which has,...

Entanglement dynamics of two electron-spin qubits in a strongly detuned and dissipative quantum-dot-cavity system

International Nuclear Information System (INIS)

Xiang Shaohua; Deng Xiaopeng; Song Kehui; Wen Wei; Shi Zhengang

2011-01-01

We investigate the entanglement dynamics of two electron-spin qubits in the quantum-dot (QD)-microcavity system in the large-detuning limit and subjected to two different noise sources: electron-spin dephasing and relaxation. We show that when one of the two dots is prepared initially in the excited state, the created entanglement exhibits oscillatory behavior at the beginning of evolution and then completely disappears over time. For two QDs that are initially in either the Einstein-Podolsky-Rosen-Bell states or the Werner states, their entanglement evolution exhibits the same behavior in the presence of pure dephasing, but is completely different under the relaxation process. We also show that the interdot interaction induced by a single-mode cavity field does not contribute to the dynamics of entanglement for these Bell states and Werner states.

Temporal and spatial changes in mixed layer properties and atmospheric net heat flux in the Nordic Seas

International Nuclear Information System (INIS)

Smirnov, A; Alekseev, G; Korablev, A; Esau, I

2010-01-01

The Nordic Seas are an important area of the World Ocean where warm Atlantic waters penetrate far north forming the mild climate of Northern Europe. These waters represent the northern rim of the global thermohaline circulation. Estimates of the relationships between the net heat flux and mixed layer properties in the Nordic Seas are examined. Oceanographic data are derived from the Oceanographic Data Base (ODB) compiled in the Arctic and Antarctic Research Institute. Ocean weather ship 'Mike' (OWS) data are used to calculate radiative and turbulent components of the net heat flux. The net shortwave flux was calculated using a satellite albedo dataset and the EPA model. The net longwave flux was estimated by Southampton Oceanography Centre (SOC) method. Turbulent fluxes at the air-sea interface were calculated using the COARE 3.0 algorithm. The net heat flux was calculated by using oceanographic and meteorological data of the OWS 'Mike'. The mixed layer depth was estimated for the period since 2002 until 2009 by the 'Mike' data as well. A good correlation between these two parameters has been found. Sensible and latent heat fluxes controlled by surface air temperature/sea surface temperature gradient are the main contributors into net heat flux. Significant correlation was found between heat fluxes variations at the OWS 'Mike' location and sea ice export from the Arctic Ocean.

Measurements of the apparent thermal conductivity of multi-layer insulation between 20 K and 90 K

International Nuclear Information System (INIS)

Hurd, Joseph A.; Van Sciver, Steven W.

2014-01-01

NASA has the need to efficiently store cryogenic propellants in space for long periods of time. One method to improve storage efficiency is to use multi-layer insulation (MLI), a technique that minimizes the boiling rate due to radiation heat transfer. Typically, the thermal performance of MLI is determined by measuring the rate of evaporation of liquid nitrogen from a calibrated cryostat. The main limitation with this method is that testing conditions are restricted by the boiling temperature of the LN 2 , which may not match the requirements of the application. The Multi-Layer Insulation Thermal Conductivity Experiment (MIKE) at the National High Magnetic Field Laboratory is capable of measuring the effective thermal conductivity of MLI at variable boundary temperatures. MIKE uses cryo-refrigerators to control boundary temperatures in the calorimeter and a calibrated thermal link to measure the heat load. To make the measurements requested by NASA, MIKE needed to be recalibrated for the 20 K to 90 K range. Also, due to the expectation of a lower heat transfer rate, the heat load support rod material was changed to one with a lower thermal conductivity to ensure the temperature difference seen on the cold rod could be measurable at the estimated heat load. Presented are the alterations to MIKE including calibration data and heat load measurements on new load-bearing MLI supplied by NASA

Temporal and spatial changes in mixed layer properties and atmospheric net heat flux in the Nordic Seas

Energy Technology Data Exchange (ETDEWEB)

Smirnov, A; Alekseev, G [SI ' Arctic and Antarctic Research Institute' , St. Petersburg (Russian Federation); Korablev, A; Esau, I, E-mail: avsmir@aari.nw.r [Nansen Environmental and Remote Sensing Centre, Bergen (Norway)

2010-08-15

The Nordic Seas are an important area of the World Ocean where warm Atlantic waters penetrate far north forming the mild climate of Northern Europe. These waters represent the northern rim of the global thermohaline circulation. Estimates of the relationships between the net heat flux and mixed layer properties in the Nordic Seas are examined. Oceanographic data are derived from the Oceanographic Data Base (ODB) compiled in the Arctic and Antarctic Research Institute. Ocean weather ship 'Mike' (OWS) data are used to calculate radiative and turbulent components of the net heat flux. The net shortwave flux was calculated using a satellite albedo dataset and the EPA model. The net longwave flux was estimated by Southampton Oceanography Centre (SOC) method. Turbulent fluxes at the air-sea interface were calculated using the COARE 3.0 algorithm. The net heat flux was calculated by using oceanographic and meteorological data of the OWS 'Mike'. The mixed layer depth was estimated for the period since 2002 until 2009 by the 'Mike' data as well. A good correlation between these two parameters has been found. Sensible and latent heat fluxes controlled by surface air temperature/sea surface temperature gradient are the main contributors into net heat flux. Significant correlation was found between heat fluxes variations at the OWS 'Mike' location and sea ice export from the Arctic Ocean.

Gut. Besser. Simmig? / Jaan J. Leppik

Index Scriptorium Estoniae

Leppik, Jaan J., 1969-

2006-01-01

Eesti-Saksa koostööfilm "Kõrini" : stsenaristid Hans-Werner Honert, Thomas Steinke, Peeter Simm, Valentin Kuik : režissöör Peeter Simm : operaator Rein Kotov : Ruut Pictures (Eesti) - Saxonia Film (Saksa) 2005

"Dostali!"

Index Scriptorium Estoniae

2006-01-01

Eesti-Saksa koostööfilm "Kõrini" : stsenaristid Valentin Kuik, Peeter Simm, Hans Werner Honert, Thomas Steinke : režissöör Peeter Simm : operaator Rein Kotov : Ruut Pictures (Eesti) - Saxonia Film (Saksa) 2005

Demonstration of Fission Product Retention in a Novel NTR Fuel, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — Several studies over the past few decades have recognized the need for advanced propulsion to explore the solar system. As early as the 1960s, Werner Von Braun and...

Demonstration of Fission Product Retention in a Novel NTR Fuel, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — Several studies over the past few decades have recognized the need for advanced propulsion to explore the solar system. As early as the 1960s, Werner Von Braun and...

New appointment at the IAEA

International Nuclear Information System (INIS)

2000-01-01

The document gives short information on the biography of Professor Dr. Werner Burkart from Germany who was appointed (as of July 2000) as Deputy Director General, Head of the Department of Nuclear Sciences and Applications, IAEA

[Die baltischen Lande im Zeitalter der Reformation und Konfessionalisierung. Livland, Estland, Ösel, Ingermanland, Kurland und Letgallen. Stadt, Land und Konfession 1500-1721. 2. und 3. Teil] / Anti Selart

Index Scriptorium Estoniae

Selart, Anti, 1973-

2012-01-01

Arvustus: Die baltischen Lande im Zeitalter der Reformation und Konfessionalisierung. Livland, Estland, Ösel, Ingermanland, Kurland und Letgallen. Stadt, Land und Konfession 1500-1721. Hrsg. von Matthias Asche, Werner Buchholz, Anton Schindling. 2. und 3. Teil.

New arrivals

CERN Document Server

2004-01-01

On Tuesday 9 March 2004, representatives of the CERN Management welcomed recently-recruited staff members and fellows at the trimester session of the Induction Programme (photographed here with Werner Zapf, Head of the Human Resources Department).

CERN's new arrivals, March 2004.

CERN Document Server

Patrice Loïez

2004-01-01

On Tuesday 9 March 2004, representatives of the CERN Management welcomed recently-recruited staff members and fellows at the trimester session of the Induction Programme (photographed here with Werner Zapf, Head of the Human Resources Department).

Removal of Heavy Metals and PAH in Highway Detention Ponds

DEFF Research Database (Denmark)

Bentzen, Thomas Ruby; Larsen, Torben; Thorndahl, Søren Liedtke

2005-01-01

, which has been designed according to standard design criteria for several decades. The study will focus on heavy metals (Cd, Cr, Cu, Pb and Zn) and polyaromatic hydrocarbons (PAH). The long-term simulation of input of flow and pollution to the ponds will be a hind cast based on time series of historical......The paper presents some of the first results from a study of the removal of pollutants in highway detention ponds in Denmark. The objective of the study is to set up a procedure for long-term modelling of discharges of pollutants to the environment from the many Danish highway detention ponds...... rainfalls. The modelling will take place in a special version of the MIKE URBAN. The modelling is calibrated and validated on measurements from selected highway catchments. The removal of pollutants in the ponds is studied by local measurements in combination with CFD modelling using the MIKE 21 and MIKE 3...

Description in Literature and Other Media

Directory of Open Access Journals (Sweden)

Thomas Van Parys

2009-10-01

Full Text Available Book Review:
Description in Literature and Other Media
Werner Wolf & Walter Bernhart, eds., Description in Literature and Other Media. Amsterdam/New
York: Rodopi, 2007.
ISBN: 978-90-420-2310-9

Vzgljanuv na sebja objektivno i zhestko / Peeter Simm ; interv. Ella Agranovskaja

Index Scriptorium Estoniae

Simm, Peeter, 1953-

2007-01-01

Anapas SRÜ ja Baltimaade XV avatud filmifestivalil "Kinoshokk 2006" peapreemia saanud Peeter Simmi mängufilmil "Kõrini!" on esitatud Venemaa filmiauhinnale "Nike". Filmi sünniloost, koostööst stsenarist-produtsent Hans-Werner Honertiga ja muust

Miscasting, TV adaptation inhibit 'Copenhagen' drama

CERN Multimedia

Winn, S

2002-01-01

Review of a television adaptation of the play 'Copenhagen', produced by Howard Davies for PBS, USA . The play speculates on the real reason that Werner Heisenberg came to see Niels Bohr in Copenhagen in 1941 (1 page).

Assessing the influence of groundwater and land surface scheme in the modelling of land surface-atmosphere feedbacks over the FIFE area in Kansas, USA

DEFF Research Database (Denmark)

Larsen, Morten Andreas Dahl; Højmark Rasmussen, Søren; Drews, Martin

2016-01-01

The land surface-atmosphere interaction is described differently in large scale surface schemes of regional climate models and small scale spatially distributed hydrological models. In particular, the hydrological models include the influence of shallow groundwater on evapotranspiration during dry...... by HIRHAM simulated precipitation. The last two simulations include iv) a standard HIRHAM simulation, and v) a fully coupled HIRHAM-MIKE SHE simulation locally replacing the land surface scheme by MIKE SHE for the FIFE area, while HIRHAM in standard configuration is used for the remaining model area...

The Size of the Universe and Where Will We Go?

Science.gov (United States)

Lawson, B. Mike

2012-01-01

As an avid engineer and amateur astronomer, Mike Lawson presented a perspective on the size of the universe and asked the question, "Where will we go?" This was an entry-level overview for the average space worker who really wanted to understand the size of stars and the distance between objects in space. Mike provided information about familiar orbital objects and elaborated more on galaxies during the discussion. He also explored where humans could go in space and the physical limitations of going there.

Environmental Assessment: Disposition of Chiefs’ Circle Residential Structures

Science.gov (United States)

2012-04-27

five structures ranged from Page 4 of 5  $200,000 (with bricks removed) to $500,000 (with bricks intact). Mike Ford, CEO of NewTown Macon, echoed Mr...feasibility 25-Jul-08 and practicality of moving the Chief’s Circle duplexes Mike Ford NewTown Macon 23-Jul-08 478-722-9909 President of NewTown Macon...Daniel.Chavira@ Gave a tour of Chiefs’ Circle huntcompanies.com Not interested in using the houses Bob Sharples RAFB 26-Oct-10 robert.sharples

Understanding Soviet Naval Developments

Science.gov (United States)

1991-07-01

submarine noise reduction technology. A single-unit experimental, deep diving SSN. SSBN in a process that converted the unit to dubbed the MIKE class, was...is second only to that of Ja- ties. When the Soviet MIKE SSN suffered a pan in total catch tonnage each year. fire in the Norwegian Sea in April of... sharpl \\ tapered nose providing better o~er-the-nose visibil- ity: this change ’. as miade possible by the absence of’ the MIiG-23’s air intercept radar

VOYAGER 1&2 JUPITER BRIGHTNESS NORTH/SOUTH MAP SET V1.0

Data.gov (United States)

National Aeronautics and Space Administration — This data set contains Voyager 1 and 2 measurements of the brightness of Jupiter at H Lyman alpha and in the H2 Lyman and Werner bands shortward of H Lyman alpha....

The early S-matrix theory and its propagation (1942-1952)

International Nuclear Information System (INIS)

Rechenberg, H.

1989-01-01

This paper describes the development of S-matrix theory in the 1940s and 1950s, which described the scattering and emission problems in elementary particle theory. Its chief architect, Werner Heisenberg, worked in Germany all through the Second World War. Communication problems were intense and made discussion of this useful tool very difficult. Werner Heisenberg's collaborative efforts with Hendrik Kramers in Holland and Christian Moeller are noted. The theory had its opponents and their objections are described. As other scientists took up the theory it was used in new ways such as in quantum electrodynamics, and to predict the creation of massive particles by analyzing S-matrix threshold behaviour. Although the theory fell into disfavour in the early 1950s, it was later readopted when ideas such as crossed channels and analytic behaviour in the complex angular-momentum plane needed explanations. (UK)

The Effects of Temperature, Hypoxia and Hypercapnia on the Metabolism of Atlantic Cod Gadus morhua

DEFF Research Database (Denmark)

Tirsgård, Bjørn

in the water conditions affecting their performance, growth and reproduction. Variations in the water conditions between years and due to climatic changes, affects the survival rate, population dynamic and bio-energetic distribution of the Atlantic cod (Hansson et al., 1996; Essington et al., 2001...... into bio-energetic models used to predict survival, growth and reproduction rates and cod stock dynamics. Furthermore, due to the growing interest of the continuing global increase in atmospheric and oceanic CO2 levels (ICES, 2010), and the rapid expansion of fish farming in land-based recirculated...... important for bio-energetic models (Werner et al., 1996; Leising and Franks, 1999; Werner et al., 2001; Lough et al., 2005). The temperature effect on the metabolism of Atlantic cod larvae however have received little attention (Laurence, 1978; Finn et al., 2002; Peck and Buckley, 2008), likely due...

Entanglement of three-qubit Greenberger-Horne-Zeilinger-symmetric states.

Science.gov (United States)

Eltschka, Christopher; Siewert, Jens

2012-01-13

The first characterization of mixed-state entanglement was achieved for two-qubit states in Werner's seminal work [Phys. Rev. A 40, 4277 (1989)]. A physically important extension concerns mixtures of a pure entangled state [such as the Greenberger-Horne-Zeilinger (GHZ) state] and the unpolarized state. These mixed states serve as benchmark for the robustness of multipartite entanglement. They share the symmetries of the GHZ state. We call such states GHZ symmetric. Here we give a complete description of the entanglement in the family of three-qubit GHZ-symmetric states and, in particular, of the three-qubit generalized Werner states. Our method relies on the appropriate parametrization of the states and on the invariance of entanglement properties under general local operations. An application is the definition of a symmetrization witness for the entanglement class of arbitrary three-qubit states.

Geometric measure of pairwise quantum discord for superpositions of multipartite generalized coherent states

International Nuclear Information System (INIS)

Daoud, M.; Ahl Laamara, R.

2012-01-01

We give the explicit expressions of the pairwise quantum correlations present in superpositions of multipartite coherent states. A special attention is devoted to the evaluation of the geometric quantum discord. The dynamics of quantum correlations under a dephasing channel is analyzed. A comparison of geometric measure of quantum discord with that of concurrence shows that quantum discord in multipartite coherent states is more resilient to dissipative environments than is quantum entanglement. To illustrate our results, we consider some special superpositions of Weyl–Heisenberg, SU(2) and SU(1,1) coherent states which interpolate between Werner and Greenberger–Horne–Zeilinger states. -- Highlights: ► Pairwise quantum correlations multipartite coherent states. ► Explicit expression of geometric quantum discord. ► Entanglement sudden death and quantum discord robustness. ► Generalized coherent states interpolating between Werner and Greenberger–Horne–Zeilinger states

Geometric measure of pairwise quantum discord for superpositions of multipartite generalized coherent states

Energy Technology Data Exchange (ETDEWEB)

Daoud, M., E-mail: m_daoud@hotmail.com [Department of Physics, Faculty of Sciences, University Ibnou Zohr, Agadir (Morocco); Ahl Laamara, R., E-mail: ahllaamara@gmail.com [LPHE-Modeling and Simulation, Faculty of Sciences, University Mohammed V, Rabat (Morocco); Centre of Physics and Mathematics, CPM, CNESTEN, Rabat (Morocco)

2012-07-16

We give the explicit expressions of the pairwise quantum correlations present in superpositions of multipartite coherent states. A special attention is devoted to the evaluation of the geometric quantum discord. The dynamics of quantum correlations under a dephasing channel is analyzed. A comparison of geometric measure of quantum discord with that of concurrence shows that quantum discord in multipartite coherent states is more resilient to dissipative environments than is quantum entanglement. To illustrate our results, we consider some special superpositions of Weyl–Heisenberg, SU(2) and SU(1,1) coherent states which interpolate between Werner and Greenberger–Horne–Zeilinger states. -- Highlights: ► Pairwise quantum correlations multipartite coherent states. ► Explicit expression of geometric quantum discord. ► Entanglement sudden death and quantum discord robustness. ► Generalized coherent states interpolating between Werner and Greenberger–Horne–Zeilinger states.

Lood erilistest inimestest / Erkki Luuk

Index Scriptorium Estoniae

Luuk, Erkki, 1971-

2002-01-01

Detsembris toimuvat Pimedate Ööde Filmifestivali on laiendatud ka suvele. Alates 6. juunist näidati Katariina kirikus kuuel õhtul Werner Herzogi (1942) filme. Režissöörist, tema lemmiknäitlejast Klaus Kinskist ja filmidest

Magnetic anomalies in Central Bengal fan

Digital Repository Service at National Institute of Oceanography (India)

Rao, T.C.S.; Lakshminarayana, S.; Sarma, K.V.L.N.S.

Total magnetic field anomalies recorded over the Central Bengal Fan are analysed and the depths to the magnetic basement are computed using the analytical signal and the Werner deconvolution methods. To the west and east of 85 degrees E...

Korralik ja normaalne eesti film / Andris Feldmanis

Index Scriptorium Estoniae

Feldmanis, Andris, 1982-

2005-01-01

IX PÖFFil esilinastus Eesti-Saksa koostööfilm "Kõrini" : stsenaristid Valentin Kuik, Peeter Simm, Hans Werner Honert, Thomas Steinke : režissöör Peeter Simm : operaator Rein Kotov : Ruut Pictures (Eesti) - Saxonia Film (Saksa) 2005

PÖFF zakrojetsa filmom "Dostalo!" / Peeter Simm ; interv. Eteri Kekelidze

Index Scriptorium Estoniae

Simm, Peeter, 1953-

2005-01-01

IX PÖFFil esilinastub Eesti-Saksa koostööfilm "Kõrini" : stsenaristid Valentin Kuik, Peeter Simm, Hans Werner Honert, Thomas Steinke : režissöör Peeter Simm : operaator Rein Kotov : Ruut Pictures (Eesti) - Saxonia Film (Saksa) 2005

Eesti-saksa pusle veebruaris kinodes / Jaan Ruus

Index Scriptorium Estoniae

Ruus, Jaan, 1938-2017

2005-01-01

IX PÖFFil esilinastus Eesti-Saksa koostööfilm "Kõrini" : stsenaristid Valentin Kuik, Peeter Simm, Hans Werner Honert, Thomas Steinke : režissöör Peeter Simm : operaator Rein Kotov : Ruut Pictures (Eesti) - Saxonia Film (Saksa) 2005

It might become light. The unity of mind and matter in quantum physics. 2. ed.

International Nuclear Information System (INIS)

Mann, Frido; Mann, Christine

2017-01-01

Christine Mann, daughter of Werner Heisenberg, and Frido Mann, grandson of Thomas Mann show in their common book the dramatic consequences of the quantum theory for our live and thinking - until a holistic view of the man in nature.

Why are animals (and humans) nice to each other?

Indian Academy of Sciences (India)

Centre for Ecological Sciences and Centre for Contemporary Studies, Indian Institute of Science,. Bangalore 560 012 .... that the altruist is willing to risk his life when the numbers .... by the German economist Werner Güth some three decades ...

It might become light. The unity of mind and matter in quantum physics. 2. ed.; Es werde Licht. Die Einheit von Geist und Materie in der Quantenphysik

Energy Technology Data Exchange (ETDEWEB)

Mann, Frido; Mann, Christine

2017-10-01

Christine Mann, daughter of Werner Heisenberg, and Frido Mann, grandson of Thomas Mann show in their common book the dramatic consequences of the quantum theory for our live and thinking - until a holistic view of the man in nature.

Summary of Federal Aviation Administration Responses to National Transportation Safety Board Safety Recommendations.

Science.gov (United States)

1982-01-01

we’re going to call now to get them on .... The controller then asked N35211 aircraft ". . . change to unicorn , click your mike twice and see if that’ll...then said, "OK we’re going to call now to get them on...." The controller then asked N35211 aircraft "... change to unicorn , click your mike twice and...number up to 1404 which have been used on aircraft with a grow takeoff weight of 430,000 pounds or more, and include in the Airworthiness Directive a

Developing Fast and Reliable Flood Models

DEFF Research Database (Denmark)

Thrysøe, Cecilie; Toke, Jens; Borup, Morten

2016-01-01

. A surrogate model is set up for a case study area in Aarhus, Denmark, to replace a MIKE FLOOD model. The drainage surrogates are able to reproduce the MIKE URBAN results for a set of rain inputs. The coupled drainage-surface surrogate model lacks details in the surface description which reduces its overall...... accuracy. The model shows no instability, hence larger time steps can be applied, which reduces the computational time by more than a factor 1400. In conclusion, surrogate models show great potential for usage in urban water modelling....

Distributed hydrological modelling of the Senegal river basin - model construction and validation

DEFF Research Database (Denmark)

Andersen, J.; Refsgaard, J.C.; Jensen, Karsten Høgh

2001-01-01

A modified version of the physically-based distributed MIKE SHE model code was applied to the 375,000 km(2) Senegal River Basin. On the basis of conventional data from meteorological stations and readily accessible databases on topography, soil types, vegetation type, etc. three models with diffe......A modified version of the physically-based distributed MIKE SHE model code was applied to the 375,000 km(2) Senegal River Basin. On the basis of conventional data from meteorological stations and readily accessible databases on topography, soil types, vegetation type, etc. three models...

Gossip column.

Science.gov (United States)

Percival, Jennifer

2002-12-11

Mike, a charge nurse on a surgical day unit, told me about Janice, his ward clerk who was always gossiping and causing trouble between people in his team. I asked what he had tried to do about it. He said that when he noticed her gossiping he had asked her for something to try to distract her. Although this put an end to the immediate problem, Mike wanted a long-term solution, especially as a new team member had asked for advice because she felt uncomfortable hearing 'stories' about her colleagues from Janice.

R-ES-ONA--NCEI

Indian Academy of Sciences (India)

His Life and Science. Werner Heisenberg was ... At Copenhagen he worked on dispersion theory ity was moulded by this ... In view of the fact that Heisenberg's work on atomic physics gener- ally involved a fair amount of daring and specula-.

Diccionario del español de Argentina

OpenAIRE

Haensch, Günther

2000-01-01

Diccionario del español de Argentina : español de Argentina - español de España / Günther Haensch ; Reinhold Werner. Madrid : Gredos, 2000. - LI, 729 S. - (Diccionarios contrastivos del español de América)

Diccionario del español de Cuba

OpenAIRE

Werner, Reinhold

2000-01-01

Diccionario del español de Cuba : español de Cuba - español de España / Günther Haensch ; Reinhold Werner. - Madrid : Gredos, 2000. - LVIII, 606 S. - (Diccionarios contrastivos del español de América)

Bringing a few new dimensions to physics - We live in a three- dimensional world - or do we? We may need as many as 11 dimensions to explain experimental findings, according to a Science Week Ireland presentation

CERN Multimedia

Ahlstrom, D

2002-01-01

Prof Werner Nahm, of the School of Theoretical Physics, last night delivered talk at the Dublin Institute for Advanced Studies entitled, 'Hidden Dimensions'. It was one of a series offered by the Institute as part of Science Week Ireland (1 page).

Ilmus teadusajakirja Rechtstheorie Eesti erinumber

Index Scriptorium Estoniae

2008-01-01

Tutvustus väljaandele: Multiple Modernität, Globalisierung der Rechtsordnung und Kommunikationsstruktur der Rechtssysteme : Internationales Symposium zur Theorie der Rechtskommunikation an der Universität Tartu im April 2006 / herausgegeben von Werner Krawietz und Raul Narits. Berlin : Duncker & Humblot, 2007

Die DDR zwischen Einheit und Abgrenzung : Höhepunkte aus der deutschen Geschichte als Paradigmen politischen Wandels : Luther, Friedrich II. und Bismarck

NARCIS (Netherlands)

Brinks, Jan Herman

1991-01-01

Im Jahre 1945 befand sich die Geschichte Deutschlands, darin besteht Konsens unter Historikern aller Richtungen, an einem ihrer tiefgreifendsten Wendepunkte. Die Ereignissein Hiroshima und in Potsdam im Sommer jenes Jahres, so urteilt Werner Conze, markieren einschneidenste Zäsuren der europdischen,

Where Are They Now: Former WHK Intern Julianne Heberlein Moves from Science to Politics | Poster

Science.gov (United States)

Former Werner H. Kirsten (WHK) intern Julianne Heberlein—who worked in the Frederick National Laboratory Public Affairs and Communication Office under Frank Blanchard—credits the WHK program with setting her apart from other applicants when applying for her recent internships.

Arctic Collaboration: Developing a Successful Researcher/Teacher Expedition

Science.gov (United States)

Skotnicki, S.; Loranty, M. M.

2016-12-01

Are you a researcher working in the polar regions of the world or a K-12 science teacher who would like to be part of a field research expedition in the polar regions? Researchers and K-12 science teachers can apply for funding from PolarTREC, a program that pairs researchers and teachers to conduct field science in Antarctica and the Arctic. Our poster presentation will offer details of one such successful researcher/teacher partnership. During the summer of 2016, Science Teacher Stan Skotnicki (Cheektowaga Central Middle School in Buffalo, NY) was teamed up with Assistant Professor Mike Loranty (Colgate University) to study vegetation and ecosystem impacts on permafrost vulnerability. Stan joined Mike and his research team in Northeastern Siberia preparing field sites, collecting data, processing samples, discussing methods, and planning daily activities. In order to raise awareness and broaden the impact of the research being conducted, Stan communicated the science through a series of journals on the PolarTREC website with his students, staff, and members of the community. Additionally, Mike and Stan held a live webinar from Siberia discussing the content of the research, the nature of the fieldwork, and why it was important to travel so far for this information. This expedition allowed Stan to experience working with a field research team for an extended period of time. Mike benefited from having a team member dedicated to learning about and communicating project details that also provided valuable field assistance. Stan gets to bring his hands-on experience back to his classroom in Buffalo and Mike has the opportunity to share his research with a new and different audience, including presenting to students at Cheektowaga Central with the help of his undergraduate students. This model of collaboration provides a number of valuable benefits for both teachers and researchers. While the PolarTREC program provides necessary logistics and funding to conduct these

Fifty-four Years of Adventures in Infrared Astronomy

Science.gov (United States)

Becklin, Eric Eric

2018-01-01

My adventures in infrared astronomy started when I was a grad student in 1965 with the discovery of an infrared-bright object (now known as the Becklin-Neugebauer Object) in the Orion Nebula. In 1966, I made the first measurements of the infrared radiation from the center of the Milky Way Galaxy. I was fortunate enough to be able to take advantage of the 2.2 micron sky survey carried out by Neugebauer and Leighton (1969), which produced many remarkable discoveries, the most spectacular being the heavily dust-embedded carbon star IRC+10216, thebrightest object in the sky at 5 microns outside the solar system. In the 1970’s there was a growth in Infrared astronomy with the availability of many new facilities such as the Kuiper Airborne Observatory, (KAO) which I used extensively with Mike Werner and Ian Gatley for many unique observations. In 1977, I moved to Hawaii to work on the NASA IRTF 3- meter telescope. Many discoveries were made, including the first direct measurements of the rings of Jupiter at 2.2 microns (with Gareth Wynn-Williams) and the discovery of the first L dwarf star around a white dwarf (with Ben Zuckerman). In the 1980’s the introduction of large format arrays changed the way we did infrared astronomy. With Ian McLean, I moved to UCLA in 1990 to start the IR lab and get involved in Keck development and science. In 1995, Andrea, Ghez, Mark Morris and I started looking for evidence of a possible massive Black Hole in the Galactic Center. Spectacular observations using the Keck10 meter telescopes with large format near-infrared arrays and adaptive optics led to the confirmation of the presence of such a black hole and an estimate of its mass (4xE6 M (Sun)). In 1996, I began working on the Stratospheric Observatory For Infrared Astronomy (SOFIA) and I will finish my talk by discussing SOFIA observations of the ring of dust and gas orbiting the massive black hole in the center

Magnetic basement in the central Bay of Bengal

Digital Repository Service at National Institute of Oceanography (India)

Sarma, K.V.L.N.S.; Ramana, M.V.; Ramprasad, T.; Desa, M.; Subrahmanyam, V.; Krishna, K.S.; Rao, M.M.M.

Analyses of about 6000 km of processed magnetic data in the central Bay of Bengal using Analytical Signal Processing and Werner Deconvolution techniques revealed that the depth to top of the magnetic basement varies between 5 and 12 km from the sea...

Delineation of structural lineaments from marine magnetic anomalies off Jonnalakonda, East Coast of India

Digital Repository Service at National Institute of Oceanography (India)

Sarma, K.V.L.N.S.; Rao, T.C.S.; Rao, D.G.

to charnockitic bodies occurring at shallow depth around 0.37 to 0.4 km and (2) the high frequency and amplitude anomalies near to the coast are trending north west-south east direction. The well developed magnetic anomaly is interpreted following automated Werner...

High-Permeability Magnetic Polymer Additives for Lightweight Electromagnetic Shielding

Science.gov (United States)

2015-08-01

incorporation) or chemical incorporation as part of the polymer chain backbone or linked as pendant groups.13 Many transition-metal organometallic...10.1002/9781119951438. 15. Poli R. Open-shell organometallics as a bridge between Werner-type and low-valent organometallic complexes: the effect

Climate policy and nonrenewable resources : The green paradox and beyond

NARCIS (Netherlands)

Pittel, Karen; van der Ploeg, Rick; Withagen, Cees

2014-01-01

Recent developments suggest that well-intended climate policies–including carbon taxes and subsidies for renewable energy – might not accomplish what policy makers intend. Hans-Werner Sinn has described a "green paradox," arguing that these policies could hasten global warming by encouraging owners

Det skadelige 'rum'

DEFF Research Database (Denmark)

Petersen, Lars Axel

2014-01-01

kortlagt. Ud over Hitlers magtfulde politiske retorik er det i Hans Grimms roman Volk ohne Raum, Karl Haushofers geopolitiske rumstudier, Konrad Meyers rumforskning, Carl Schmitts udkast til en ’folkeretslig storrumsordning’ samt i Werner Bests maximer for en etnicistisk storrumsforvaltning, at rum...

Fulltext PDF

Indian Academy of Sciences (India)

Brick Masonry Houses Behave during Earthquakes? CVRMurly. PERSONAL REFLECTIONS. 93 Jochen and Werner Heisenberg. Front Cover. Back Cover. -'". Pictures of Uranus taken during Voyager 2 mission. Sophisticated error correcting codes were used in the transmission of these images. (Credit: Public Information ...

In the beginning was information

CERN Document Server

Gitt, Werner, Dr

2006-01-01

Information is the cornerstone of life, yet it is something people don't often think about. In his fascinating new book, In the Beginning Was Information, Dr. Werner Gitt helps the reader see how the very presence of information reveals a Designer.

Ilmaelu läbi irooniaprisma / Ragne Nukk

Index Scriptorium Estoniae

Nukk, Ragne, 1984-

2010-01-01

Kunstnikeduo Johnson ja Johnson (Taavi Talve, Indrek Köster) näitus "Nothing Left to Save" Draakoni galeriis 15. maini 2010. Näitus põhineb saksa režissööri Rainer Werner von Fassbinderi filmil "Petra von Kanti kibedad pisarad"

Unusual bridging of three nitrates with two bridgehead protons in an octaprotonated azacryptand

Science.gov (United States)

Saeed, Musabbir A.; Fronczek, Frank R.; Huang, Ming-Ju; Hossain, Md. Alamgir

2010-01-01

Structural analysis of the nitrate complex of a thiophene-based azacryptand suggests that three nitrates are bridged with two bridgehead protons which play the topological role of two transition metal ions in a classical Werner type coordination complex bridging three anions. PMID:20066306

Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells

DEFF Research Database (Denmark)

Bacolla, Albino; Wang, Guliang; Jain, Aklank

2011-01-01

Although alternative DNA secondary structures (non-B DNA) can induce genomic rearrangements, their associated mutational spectra remain largely unknown. The helicase activity of WRN, which is absent in the human progeroid Werner syndrome, is thought to counteract this genomic instability. We dete...

Ombuds’ corner: Work conflict or harassment?

CERN Multimedia

Vincent Vuillemin

2011-01-01

In this series, the Bulletin aims to explain the role of the Ombuds at CERN by presenting practical examples of misunderstandings that could have been resolved by the Ombuds if he had been contacted earlier. Please note that, in all the situations we present, the names are fictitious and used only to improve clarity.   Bill*, thanks to his technical competence, has been nominated leader of a group in charge of various projects. During his learning phase, he benefited from the experience of his collaborators and had a good working relationship with all of them. However, after few months, his relationship with Mike*, a senior member of the group in charge of some specific developments, turned sour. As the situation did not improve after many weeks, Mike decided to file an informal complaint of harassment with the Ombuds against his group leader, as he was convinced that Bill was bullying him. Mike explained that Bill was interfering more and more with his responsibilities in the project, by interac...

Dissociation mechanism of HNIW ions investigated by chemical ionization and electron impact mass spectroscopy

Energy Technology Data Exchange (ETDEWEB)

Yang, Rongjie; Xiao, Hemiao [School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081 (China)

2006-04-15

Chemical Ionization (CI) with Collision-Induced Dissociation (CID) spectroscopy and Electron Impacting (EI) with metastable Mass analyzed Ion Kinetic Energy (MIKE) spectroscopy have been applied to study ionic dissociations of Hexanitrohexaazaisowurtzitane (HNIW). Similarities and differences between EI/MIKE and CI/CID mass spectra of HNIW were analyzed. In EI mass spectra, the ions [HNIW-n NO{sub 2}]{sup +} (n=2-5), such as the ion at m/z 347, were less frequent (1-2% relative abundance), but in CI mass spectra, these ions were very abundant. For some ions of large molar mass from HNIW, their dissociations pathways from parent ions to daughter ions were built according to CID and MIKE spectra. Molecular ions of HNIW with a protonated nitro group at five-member ring seem more stable than at six-member ring. The HNIW ions losing five of six nitro groups are very stable based on CID spectra, which agrees with some research results for thermal decomposition of HNIW in literature. (Abstract Copyright [2006], Wiley Periodicals, Inc.)

Use of lasers at the Los Alamos Hot-Cell Facility

International Nuclear Information System (INIS)

Lazarus, M.E.

1983-01-01

An optical profilometer that uses a Techmet LaserMike scanning, focused, laser-beam, optical micrometer is installed in a remote alpha-gamma containment cell at the Los Alamos Hot-Cell Facility. A hot-cell extension chamber provides the nominal 30-cm (12-in.) working distance required by the LaserMike and, at the same time, keeps the LaserMike components outside the high-radiation-containment environment. This system provides measurement accuracy better than +- 5 μm (0.0002 in.) on diameters between 2 and 13 mm (0.88 and 0.5 in.) at a rate of 33 measurements per second. The Hot-Cell Facility also uses a Korad 20-J-output ruby pulsed laser to drill a hole in reactor-fuel-element cladding to sample fission gas. The laser is then used to reweld the hole so that the fuel element will not be contaminated and may be stored without an alpha-containment barrier. The wall thickness of the fuel elements sampled varies from 0.25 to 0.50 mm (0.010 to 0.020 in.)

The determination of the mixing height. Current progress and problems

Energy Technology Data Exchange (ETDEWEB)

Gryning, S.E.; Beyrich, F.; Batchvarova, E. [eds.

1997-10-01

This report contains extended abstracts of presentations given at a EURASAP Workshop on The Determination of the Mixing Height - Current Progress and Problems. The Workshop, initiated from discussions with Peter Builtjes, was held at Risoe National Laboratory 1-3 October 1997 within the framework of EURASAP (European Association for the Sciences of Air Pollution). The specific topics and chairpersons of the Workshop were: Theoretical Considerations (Sven-Erik Gryning), Mixing Height Estimation from Turbulence Measurements and In-Situ Soundings (Douw Steyn), Mixing Height Determination from NWP-Models (Han van Dop), Climatology and Global Aspects (Werner Klug), Mixing Height Determination from Remote Systems (Werner Klug), Verification of Mixing Height Parameterizations and Models (Frank Beyrich), Mixing Height over Complex Terrain (Ekaterina Batchvarova), Internal Boundary Layers: Mixing Height in Coastal Areas and Over Cities (Allen White). The discussion at the end of the Workshop was chaired by Robert Bornstein. (au)

Measuring up to the challenges of the 21st century. An international evaluation of the Centre for Metrology and Accreditation

Energy Technology Data Exchange (ETDEWEB)

Clapman, P.; Kaarls, R.; Temmes, M.

1997-04-01

The international evaluation of the Centre for Metrology and Accreditation (MIKES) is part of the process in which all relevant industrial and technology policy measures and organizations under the auspices of the Ministry of Trade and Industry (MTI) are being evaluated with the aim of improving their effectiveness. The overall conclusion of the evaluation is that MIKES is serving the country well. An effective national measurement system (FINMET) is being maintained which provides a wide range of calibration services covering most of the nation`s needs. The accreditation service (FINAS) is now well established, is operating effectively, and has good prospects for growth. The evaluators present, however, a number of proposals (including 33 specific recommendations) where they feel that the metrology and accreditation arrangements could be better-suited to meet future national and international challenges. According to the recommendations the Finnish quality policy framework should be developed in a consistent way. There is a need of a comprehensive governmental quality policy statement upon which the inter-ministry coordination and harmonization of various conformity assessment activities can be based. MIKES should retain its current status as an agency within MTI. The national measurement system should be more centralised and a new purpose-built national standards laboratory should be procured. The responsibility for legal metrology should be transferred to MIKES. The terms of reference and membership of Advisory Committee for Metrology, as well as the Advisory Committee for Accreditation should be revised to ensure wider representation of all relevant, and especially industrial interests

Stochastic simulations of normal aging and Werner's syndrome.

KAUST Repository

Qi, Qi; Wattis, Jonathan A D; Byrne, Helen M

2014-01-01

aging. Using this model, we study various hypotheses for the way in which shortening occurs by comparing their impact on aging at the chromosome and cell levels. We consider different types of length-dependent loss and replication probabilities

Werner-Heisenberg-Institut fuer Physik. Annual report 1982

International Nuclear Information System (INIS)

1982-12-01

This annual report contains extended abstracts about the work done at the named institute together with a list of publications, speeches, seminars, and lectures. The work concerns experimental studies on high energy physics at CERN and at the PETRA storagering with the CELLO detector together with some planned experiments on the Tevatron accelerator, developments for future LEP experiments, theoretical studies on grand unification, QCD phenomenology, lattice gauge theories, supergravity, quantum mechanics, and non-relativistic many-body theory, as well as developments of radiation detectors. (HSI) [de

OHD/HL - RFCDEV/HVT: 2nd charter

Science.gov (United States)

success criteria defined here no later than September 30, 2011. No travel beyond a RFC verification /HSD) Larry Lowe (ABRFC verification focal point) James Coe (APRFC verification focal point) Ashley Nielson (CBRFC verification focal point) Kevin Werner (CBRFC verification co-focal point and SCH

Technology Horizons: A Vision for Air Force Science and Technology 2010-30

Science.gov (United States)

2011-09-01

Terrell Cover Art and Book Design and Illustrations Daniel Armstrong Composition and Prepress Production Ann Bailey Print Preparation and Distribution Diane Clark ...Air Force History and Mu- seums Program, 2002. Karagozian, Ann , Werner Dahm, Ed Glasgow, Roger Howe, Ilan Kroo, Richard Murray, and Heidi Shyu

On the Translation of Advertising Texts - Some Aspects of Attracting Attention

DEFF Research Database (Denmark)

Nielsen, Martin

2003-01-01

-psychological condition of the human organism where it is alert and capable of performing, including receiving, processing and storing information (Kroeber-Riel, Werner & Weinberg, Peter (1996): Konsumentenverhalten. Munich: Vahlen). In the cases where this activation cannot be achieved by the textual means of cognitive...

Omaenese edevuse ohver Timothy Treadwell / Mati Kaal

Index Scriptorium Estoniae

Kaal, Mati, 1946-

2007-01-01

Dokumentaalfilm "Grislimees" ("Grizzly Man") Timothy Treadwellist, kes elas 13 aastat Alaskal koos grislidega, režissöör Werner Herzog (Ameerika Ühendriigid, 2005). Tallinna Loomaaia direktor arutleb inimliku edevuse teemal, mis metsikus looduses viis režissööri traagilise hukuni

A role for the fission yeast Rqh1 helicase in chromosome segregation

DEFF Research Database (Denmark)

Win, Thein Z; Mankouri, Hocine W; Hickson, Ian D

2005-01-01

Schizosaccharomyces pombe Rqh1 protein is a member of the RecQ DNA helicase family. Members of this protein family are mutated in several human genome instability syndromes, including Bloom, Werner and Rothmund-Thomson syndromes. RecQ helicases participate in recombination repair of stalled...

Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples

DEFF Research Database (Denmark)

Lachapelle, Sophie; Gagné, Jean-Philippe; Garand, Chantal

2011-01-01

Werner syndrome (WS) is characterized by the premature onset of several age-associated pathologies. The protein defective in WS patients (WRN) is a helicase/exonuclease involved in DNA repair, replication, telomere maintenance, and transcription. Here, we present the results of a large-scale prot...

Kvantifisering av overvann: Case Brøset

OpenAIRE

Huurnink, Jon Egenberg

2012-01-01

Oppgaven forsøker å vise den systemresponsen som er særegen for konvensjonelle tiltak og blå-grønne tiltak. Dette er aktuelt på Brøset bydel som en del av Fremtiden byer prosjektet og skal bygges om til boligområde. MIKE URBAN og MIKE 21 er benyttet til å lage en konseptuell modell.Ved å sammenligne sommer- og vinterforhold, i tillegg til ulike gjentaksintervaller (1, 20 og 100år), vil kurver for videreført vannmengde gi et inntrykk av tiltakenes effekt. Dette gir beslutningsstøtte for Komm...

Grab That Mike: communicative issues in French Talk Show "Grab That Mike": questões comunicativas em um "Talk Show" Francês

Directory of Open Access Journals (Sweden)

Ludwina Van Son

2004-12-01

Full Text Available In this analysis we have chosen a recent French talk show to illustrate how communication is turned into some new kind of "ideology"nowadays: in other words, you have to communicate if you consider yourself a citizen of today's world. The main characteristic of issue-centered talk shows being the destabilization of the implicit rules and participation framework, we observe how the so-called democratic right to express ourselves is (misused by the talk show host to secure the dynamics of the show. In order to reveal the host's manipulations, we have examined the verbal interactions between host and guests on the following issues: topic choice, turn-taking mechanisms and identity construction of the talk show's guests. In the perspective that this kind of talk show presents itself as a public space where direct democracy can be exercised, the analysis of the discursive strategies of the talk show host reveals the impact of a mediatic participation framework.Para a presente análise escolhemos um "talk show" francês recente para ilustrar como a comunicação se transforma em um novo tipo de ideologia: em outras palavras, você deve se comunicar se você se considera um cidadão do mundo de hoje. Sendo a principal característica do talk show a desestabilização das regras implícitas e o framework de participação, observamos como o tal direito democrático de expressão é interpretado pelo apresentador para manter a dinâmica do programa. Para revelar suas manipulações, examinamos as interações verbais entre apresentador e convidados nos seguintes temas: escolha do tópico, mecanismos de tomada de turno e construção de identidade dos convidados. É nessa perspectiva que este tipo de programa se apresenta como um espaço público onde a democracia direta pode ser exercitada; a análise das estratégias discursivas do apresentador do talk show revela o impacto de um framework de participação mediada.

Sensitivity analysis and development of calibration methodology for near-surface hydrogeology model of Laxemar

Energy Technology Data Exchange (ETDEWEB)

Aneljung, Maria; Sassner, Mona; Gustafsson, Lars-Goeran (DHI Sverige AB, Lilla Bommen 1, SE-411 04 Goeteborg (Sweden))

2007-11-15

This report describes modelling where the hydrological modelling system MIKE SHE has been used to describe surface hydrology, near-surface hydrogeology, advective transport mechanisms, and the contact between groundwater and surface water within the SKB site investigation area at Laxemar. In the MIKE SHE system, surface water flow is described with the one-dimensional modelling tool MIKE 11, which is fully and dynamically integrated with the groundwater flow module in MIKE SHE. In early 2008, a supplementary data set will be available and a process of updating, rebuilding and calibrating the MIKE SHE model based on this data set will start. Before the calibration on the new data begins, it is important to gather as much knowledge as possible on calibration methods, and to identify critical calibration parameters and areas within the model that require special attention. In this project, the MIKE SHE model has been further developed. The model area has been extended, and the present model also includes an updated bedrock model and a more detailed description of the surface stream network. The numerical model has been updated and optimized, especially regarding the modelling of evapotranspiration and the unsaturated zone, and the coupling between the surface stream network in MIKE 11 and the overland flow in MIKE SHE. An initial calibration has been made and a base case has been defined and evaluated. In connection with the calibration, the most important changes made in the model were the following: The evapotranspiration was reduced. The infiltration capacity was reduced. The hydraulic conductivities of the Quaternary deposits in the water-saturated part of the subsurface were reduced. Data from one surface water level monitoring station, four surface water discharge monitoring stations and 43 groundwater level monitoring stations (SSM series boreholes) have been used to evaluate and calibrate the model. The base case simulations showed a reasonable agreement

Flight test report: Focke wulf PIAGGIO P149D-TP

CSIR Research Space (South Africa)

Barker, D

2015-12-01

Full Text Available It’s a story of following one’s dream. Belonging to Werner Heiml, ZU-SFP originated from Germany where it was used as a basic trainer in the Luftwaffe. The P149D was originally developed and manufactured by Piaggio & Co, Italy, in 1953...

Coordination of cassava starch to metal ions and thermolysis of ...

African Journals Online (AJOL)

Cassava starch formed Werner-type complexes with ions of metals from the transition groups. This was proven by conductivity and electron paramagnetic resonance measurements. The coordination of starch to central metal ions influenced the thermal decomposition of starch. As a rule complexes started to decompose at ...

The Social Relevance of Montessori in the First Plane

Science.gov (United States)

Andrews, Sarah Werner

2015-01-01

This article represents an amazing reversal of linguistic analysis. Usually Montessori language is translated into "state" terminology. In this case, Sarah Werner Andrews puts state quality assessment terms into Montessori language. For example, domains for school readiness include 1) physical wellbeing and motor development, 2) social…

Eight Nobel prizewinners at CERN in 1962

CERN Multimedia

1962-01-01

In 1962, CERN hosted the 11th International Conference on High Energy Physics. Among the distinguished visitors were eight Nobel prizewinners. Left to right: Cecil F Powell, Isidor I Rabi, Werner Heisenberg, Edwin M McMillan, Emile Segre, Tsung Dao Lee, Chen Ning Yang and Robert Hofstadter.

Retrofilm kultusõudukast / Aare Ermel

Index Scriptorium Estoniae

Ermel, Aare, 1957-2013

2004-01-01

Mängufilm "Vampiiri vari" ("The Shadow of the Vampire") : režissöör E. Elias Merhige : Ameerika Ühendriigid - Suurbritannia 2000. Inspireerituna samast F.W. Murnau õudusfilmist "Nosferatu, õuduste sümfoonia" (1922), oli ka Werner Herzog loonud 1978.a. filmi "Nosferatu - öö fantoom"

Strategies for High-Resolution 3-D Millimeter Wave Imaging.

Science.gov (United States)

1987-02-01

Co-Investigator K.S. Lee - Graduate Student (50%) P. Frangos - Graduate Student (50%) Y. Shen - Graduate Student (50%) K. Schultz - Graduate...period of this report: * P. Frangos (Ph.D.) - "One-Dinensionl Inverse Scattering: Exact Methods and Applications", * C.L. Werner (Ph.D.) - ŗ-D

Jõuluks koju ehk Saksamaa aina suurema surve all / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2011-01-01

Soome rahandusministri Jutta Urpilaineni hinnangul võiks mõelda Euroopa Keskpanga rolli tugevdamisele. Ühiseid eurovõlakirju toetava Austria peaministri Werner Faymanni sõnul võiks Euroopa Keskpank ise osta riikide võlakirju. Saksamaa kaalub kuue AAA-reitinguga euroala riigi ühiste võlakirjade väljaandmist

A Developmental Framework for Enhancing Resiliency in Adult Survivors of Childhood Abuse

Science.gov (United States)

Orbke, Samantha; Smith, Heather L.

2013-01-01

Roughly one third of children subjected to abusive environments grow into healthy and capable adults, demonstrating remarkable resiliency, despite risks for developing maladaptive self-structures and destructive behaviors (Werner, "American Journal of Orthopsychiatry" 59:72-81 1989; Kendall-Tackett "et al.", "Psychological Bulletin" 113:164-180…

Air Superiority and Airfield Attack - Lessons from History.

Science.gov (United States)

1984-05-15

and present, but also their essential differences.ŗ This monograph and the classified companion , which presents specific options for airbase attack...Turning Points in the German Air Force War Effort, (USAF Historical Study 189), p. 36. 5. Shakespeare , Macbeth I, vii, 1. 6. Werner Gerbig, Six Months

Trying to explain Copenhagen

CERN Document Server

2003-01-01

The documentary "The Copenhagen Fallout" recounts the friendship and "falling out" of Niels Bohr and Werner Heisenberg, two of the greatest contemporary physicists - friends whom war turned into enemies. It will be shown at CERN on 1st December. During a lecture in Germany towards the end of 1922, a 20-year-old physicist dared to interrupt Physics Nobel-Prize winner Niels Bohr with the words "There is a mathematical error in what you have said." The young scientist in question was none other than Werner Heisenberg. From this audacious beginning a fruitful collaboration and great friendship grew. But World War II threw up a wall of incomprehension between the two scientists, as one worked for the Nazi regime and the other opened his Copenhagen institute to German Jewish scientists. Then came their famous meeting in September 1941, dramatised by the no less famous play "Copenhagen", currently being performed in association with CERN at th...

Cine club

CERN Multimedia

Cine Club

2016-01-01

Wednesday 1st June 2016 at 20:00 CERN Council Chamber The Dark Glow of the Mountains Directed by Werner Herzog Germany, 1985, 45 minutes Werner Herzog follows mountaineers Hans Kammerlander and Reinhold Messner during their expedition into climbing the Gasherbrum mountains, which has some of the most difficult peaks to be conquered, and they'll do it without the use of oxygen tanks. Herzog also takes some time to hear about their past experiences with other mountains, their personal tragedies and the reasons why they are so involved with such activity. Original version German; English subtitles   The Challenge Directed by Milton Rosmer, Luis Trenker UK, 1938, 76 minutes In 1865, the unconquered Matterhorn beckons; former rivals, Italian Carrel and Englishman Whymper, hope to climb it together, but national rivalry intervenes. Rival parties dangerously race for the summit in realistic, well-photographed climbing scenes; but when the mountain is climbed, the danger is far from over.... Origina...

A big win for the CERN Golf Club at the ASCERI tournament

CERN Multimedia

Katarina Anthony

2010-01-01

The CERN Golf Club returned victorious from the autumn ASCERI (Association of the Sports Communities of the European Research Institutes) tournament which was held from 17 to 20 September.   The CERN Golf Team (left to right: Peter Jones, Alasdair Ross, Claes Frisk and Per Werner) celebrates its victories at ASCERI. Competitions took place on the Dreihof Golf Club at Essingen in southern Germany, starting with the singles Stableford competition on the first day and a 4 ball, better ball Stableford group competition the next day. CERN’s four-man team – Peter Jones, Per Werner, Claes Frisk and Alasdair Ross – came first in the group competition, with Peter Jones, CERN’s star golfer from the IT Department, winning the individual competition. The autumn ASCERI tournament included competitions in football, tennis and cart racing as well as golf. Over 230 representatives of research institutes across Europe took part. “The CERN Golf Club only began p...

The historical development of modern virus research in Germany, especially in the Kaiser-Wilhelm-/Max-Planck-Society, 1936--1954.

Science.gov (United States)

Butenandt, A

1977-01-01

This is lecture on the historical development of modern virus research in Germany to introduce a symposium dedicated to Prof. Werner Schäfer, Tübingen, on the occasion of his 65th birthday. The author was set the task of relating from his memories the beginning of modern virus research in Germany. This research has, since 1936, essentially taken place in the Kaiser-Wilhelm/Max-Planck-Society and in 1954 led to the founding of the Max-Planck-Institute for Virus Research in Tübingen, an institute which to the present day owes its scientific reputation in considerable part to the activity of Werner Schäfer. Since the author personally experienced and participated in the Institute's development from 1936-1954, his remarks are predominantly influenced by personal recollections, which have been sharpended by a renewed study of old records in the 'Library and Archive of the History of the Max-Planck-Gesellschaft', Berlin-Dahlem.

The Logarithmic-to-Linear Shift: One Learning Sequence, Many Tasks, Many Time Scales

Science.gov (United States)

Siegler, Robert S.; Thompson, Clarissa A.; Opfer, John E.

2009-01-01

The relation between short-term and long-term change (also known as learning and development) has been of great interest throughout the history of developmental psychology. Werner and Vygotsky believed that the two involved basically similar progressions of qualitatively distinct knowledge states; behaviorists such as Kendler and Kendler believed…

Suvekino näitab Herzogi filme / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

2002-01-01

Detsembris toimuvat Pimedate Ööde Filmifestivali laiendatakse ka suvele, et sobivates paikades näidata väärtfilme. Alates 6. juunist näidatakse Katariina kirikus kuuel õhtul algusega kell 22 Werner Herzogi (1942) filme. Režissöörist ja näidatavatest filmidest

1972, pp. 136. 76

African Journals Online (AJOL)

WERNER MASER: Adolf Hitler. legende, mythe, werkelijkheid. Uitgeverij De Arbeiders- pers, Amsterdam, 1973, pp. 531. Met aante- keninge [pp. 429 -. 506] en bibliografie. [pp. 507 - 531]. In 1945 het die skrywer van hierdie studie, op grond van 'n proefskrif oor die doelbewuste aankweek van die Hitlerlegende tot 1924,.

torily resolved by the author in footnote 172 [p.113]. Then there are ...

African Journals Online (AJOL)

WERNER MASER: Adolf Hitler. legende, mythe, werkelijkheid. Uitgeverij De Arbeiders- pers, Amsterdam, 1973, pp. 531. Met aante- keninge [pp. 429 -. 506] en bibliografie. [pp. 507 - 531]. In 1945 het die skrywer van hierdie studie, op grond van 'n proefskrif oor die doelbewuste aankweek van die Hitlerlegende tot 1924,.

Fulltext PDF

Indian Academy of Sciences (India)

teachers alike) a very brief account of some of. Heisenberg's general ... apart from their technical scientific work. In contrast ... of the impact of modern discoveries on time- honored ... Recollections of a Life with Werner Heisenberg ... But, lacking all knowledge of the empirical ... Such a finely balanced and refreshingly honest.

Die Geognosie der Vulkane

Directory of Open Access Journals (Sweden)

Herbert Pieper

2006-10-01

Full Text Available Article in German, Abstract in English.The paper deals with Alexander von Humboldt’s researches into the “Geognosy” of volcanoes. In the long run these researches led him to changing his views from the "neptunistic" doctrine of Abraham Gottlob Werner to the concept of "vulcanism".

Data Centre Infrastructure & Data Storage @ Facebook

CERN Multimedia

CERN. Geneva; Garson, Matt; Kauffman, Mike

2018-01-01

Several speakers from the Facebook company will present their take on the infrastructure of their Data Center and Storage facilities, as follows: 10:00 - Facebook Data Center Infrastructure, by Delfina Eberly, Mike Kauffman and Veerendra Mulay Insight into how Facebook thinks about data center design, including electrical and cooling systems, and the technology and tooling used to manage data centers. 11:00 - Storage at Facebook, by Matt Garson An overview of Facebook infrastructure, focusing on different storage systems, in particular photo/video storage and storage for data analytics. About the speakers Mike Kauffman, Director, Data Center Site Engineering Delfina Eberly, Infrastructure, Site Services Matt Garson, Storage at Facebook Veerendra Mulay, Infrastructure

Random walk loop soups and conformal loop ensembles

NARCIS (Netherlands)

van de Brug, T.; Camia, F.; Lis, M.

2016-01-01

The random walk loop soup is a Poissonian ensemble of lattice loops; it has been extensively studied because of its connections to the discrete Gaussian free field, but was originally introduced by Lawler and Trujillo Ferreras as a discrete version of the Brownian loop soup of Lawler and Werner, a

Emad kinolinal / Maria Ulfsak-Sheripova

Index Scriptorium Estoniae

Ulfsak-Šeripova, Maria, 1981-

2007-01-01

Filmid : Roger Mitchelli "Ema", Douglas Sirki "Kõik, mida taevas lubab", Rainer Werner Fassbinderi "Hirm närib hinge seest", Todd Haynesi "On taevas nii kaugel", Alfred Hitchcocki "Psühho", Woody Alleni "New Yorgi lood", Lars von Trieri "Idioodid", "Alieni" filmid, Pedro Almodovari "Kõik minu emast" ja Catherine Breillat' "Romanss"

Accurate quantum calculations of the reaction rates for H/D+ CH4

NARCIS (Netherlands)

Harrevelt, R. van; Nyman, G.; Manthe, U.

2007-01-01

In previous work [T. Wu, H. J. Werner, and U. Manthe, Science 306, 2227 (2004)], accurate quantum reaction rate calculations of the rate constant for the H+CH4 -> CH3+H-2 reaction have been presented. Both the electronic structure calculations and the nuclear dynamics calculations are converged with

Quantitative XPS analysis of thin iron-oxide films

DEFF Research Database (Denmark)

Graat, P.C.J.; Somers, Marcel A. J.

1997-01-01

Over the last decade Tougaard et al. (see e.g. Ref. 1) provided a formalism to calculate the contribution of inelastically scattered electrons to an XPS or AES spectrum. In that formalism it was assumed that the signal electrons move along straight lines to the surface. Recently, Werner et al. pr...

Werner sombart e il lusso: da una torsione di significato alla sue derive - A Contemporary Perspective Werner Sombart’s conceptualisation of Luxury

Directory of Open Access Journals (Sweden)

Sarah Siciliano

2015-03-01

Full Text Available How does the “spirit” of capitalism and luxury read from a Sombartian perspective translate into a modern day context? What legacy has this German scholar, so admired in life, but now almost forgotten, left behind? This paper reflects on what his theories can lend to contemporary analysis and what questions it can raise. The author illustrates how seeing modern day luxury through the eyes Sombart might be productive to understand and appreciate the recent consumer phenomena. The paper will focus primarily on the particular dynamics of the public sphere in an attempt to reflect and explore the cultural and political dimensions of the modern day world.

76 FR 3885 - Notice of Receipt of a Pesticide Petition Filed for Residues of Pesticide Chemicals in or on...

Science.gov (United States)

2011-01-21

... (703) 305-5805. FOR FURTHER INFORMATION CONTACT: Mike Mendelsohn, Biopesticides and Pollution.... Dated: January 6, 2011. Keith A. Matthews, Acting Director, Biopesticides and Pollution Prevention...

Integrated Hydrographical Basin Management. Study Case - Crasna River Basin

Science.gov (United States)

Visescu, Mircea; Beilicci, Erika; Beilicci, Robert

2017-10-01

Hydrographical basins are important from hydrological, economic and ecological points of view. They receive and channel the runoff from rainfall and snowmelt which, when adequate managed, can provide fresh water necessary for water supply, irrigation, food industry, animal husbandry, hydrotechnical arrangements and recreation. Hydrographical basin planning and management follows the efficient use of available water resources in order to satisfy environmental, economic and social necessities and constraints. This can be facilitated by a decision support system that links hydrological, meteorological, engineering, water quality, agriculture, environmental, and other information in an integrated framework. In the last few decades different modelling tools for resolving problems regarding water quantity and quality were developed, respectively water resources management. Watershed models have been developed to the understanding of water cycle and pollution dynamics, and used to evaluate the impacts of hydrotechnical arrangements and land use management options on water quantity, quality, mitigation measures and possible global changes. Models have been used for planning monitoring network and to develop plans for intervention in case of hydrological disasters: floods, flash floods, drought and pollution. MIKE HYDRO Basin is a multi-purpose, map-centric decision support tool for integrated hydrographical basin analysis, planning and management. MIKE HYDRO Basin is designed for analyzing water sharing issues at international, national and local hydrographical basin level. MIKE HYDRO Basin uses a simplified mathematical representation of the hydrographical basin including the configuration of river and reservoir systems, catchment hydrology and existing and potential water user schemes with their various demands including a rigorous irrigation scheme module. This paper analyzes the importance and principles of integrated hydrographical basin management and develop a case

Epistemology and Probability

CERN Document Server

Plotnitsky, Arkady

2010-01-01

Offers an exploration of the relationships between epistemology and probability in the work of Niels Bohr, Werner Heisenberg, and Erwin Schrodinger; in quantum mechanics; and in modern physics. This book considers the implications of these relationships and of quantum theory for our understanding of the nature of thinking and knowledge in general

RecQ Helicases

DEFF Research Database (Denmark)

Larsen, Nicolai Balle; Hickson, Ian D

2013-01-01

The RecQ family of DNA helicases is highly conserved throughout -evolution, and is important for the maintenance of genome stability. In humans, five RecQ family members have been identified: BLM, WRN, RECQ4, RECQ1 and RECQ5. Defects in three of these give rise to Bloom's syndrome (BLM), Werner...

Jukebox'i ja tšello kohtumine / Donald Tomberg

Index Scriptorium Estoniae

Tomberg, Donald, 1972-

2006-01-01

Eesti-Saksa koostööfilm "Kõrini" : stsenaristid Hans-Werner Honert, Thomas Steinke, Valentin Kuik, Peeter Simm : režissöör Peeter Simm : operaator Rein Kotov : helilooja Sven Grünberg : osades Maarja Jakobson, Rasmus Kaljujärv, Heio von Stetten, Thomas Schmauser : Ruut Pictures (Eesti) - Saxonia Film (Saksa) 2005

Synthesis of some quinoline-pyrazoline-based naphthalenyl ...

African Journals Online (AJOL)

naphthalenyl thiazole derivatives and their evaluation as ... naphthalen-2-yl derivative) exhibited antimicrobial activities that were higher than those of the ...... Asia. J Patient Saf Infec Cont 2013; 1(1): 19-21. 10. Brandt C, Makarewicz O, Fischer T, Stein C, Pfeifer Y,. Werner G, Pletz MW. The bigger picture: the history of.

Herzog's Rebellious Spirit and Dream Passion in Stroszek

Institute of Scientific and Technical Information of China (English)

程露

2017-01-01

Werner Herzog is a rebellious artist and lonely dreamer.Throughout his whole career, Herzog enthusiastically and persis-tently pursues cinematic dream, courting disasters and overcoming the seemingly insurmountable. This paper argues that Stroszek reflects Herzog's rebellious spirit and dream passion in its combination of the documentary with fiction, ecstatic truth and heroic characters.

Sensitivity analysis and development of calibration methodology for near-surface hydrogeology model of Laxemar

International Nuclear Information System (INIS)

Aneljung, Maria; Sassner, Mona; Gustafsson, Lars-Goeran

2007-11-01

This report describes modelling where the hydrological modelling system MIKE SHE has been used to describe surface hydrology, near-surface hydrogeology, advective transport mechanisms, and the contact between groundwater and surface water within the SKB site investigation area at Laxemar. In the MIKE SHE system, surface water flow is described with the one-dimensional modelling tool MIKE 11, which is fully and dynamically integrated with the groundwater flow module in MIKE SHE. In early 2008, a supplementary data set will be available and a process of updating, rebuilding and calibrating the MIKE SHE model based on this data set will start. Before the calibration on the new data begins, it is important to gather as much knowledge as possible on calibration methods, and to identify critical calibration parameters and areas within the model that require special attention. In this project, the MIKE SHE model has been further developed. The model area has been extended, and the present model also includes an updated bedrock model and a more detailed description of the surface stream network. The numerical model has been updated and optimized, especially regarding the modelling of evapotranspiration and the unsaturated zone, and the coupling between the surface stream network in MIKE 11 and the overland flow in MIKE SHE. An initial calibration has been made and a base case has been defined and evaluated. In connection with the calibration, the most important changes made in the model were the following: The evapotranspiration was reduced. The infiltration capacity was reduced. The hydraulic conductivities of the Quaternary deposits in the water-saturated part of the subsurface were reduced. Data from one surface water level monitoring station, four surface water discharge monitoring stations and 43 groundwater level monitoring stations (SSM series boreholes) have been used to evaluate and calibrate the model. The base case simulations showed a reasonable agreement

Plaadid / Immo Mihkelson

Index Scriptorium Estoniae

Mihkelson, Immo, 1959-

2004-01-01

Uutest heliplaatidest Gretchen Wilson "Here For The Party", A Bossa Eletrica "Eletrificacao", "Liinatuuraq", The Temptations "Legacy", Mike & The Mechanics+Paul Carrack "Rewired", Pauline London "Quiet Skies"

Automated Budget System -

Data.gov (United States)

Department of Transportation — The Automated Budget System (ABS) automates management and planning of the Mike Monroney Aeronautical Center (MMAC) budget by providing enhanced capability to plan,...

78 FR 19510 - Endangered and Threatened Wildlife and Plants; Initiation of 5-Year Reviews of 56 Species in...

Science.gov (United States)

2013-04-01

..., Reno, Nevada 89502. Stickleback, unarmored Gasterosteus Endangered........ U.S.A. (CA)....... 35 FR 16047; 10/13/ Mike McCrary (above). threespine. aculeatus 1970. williamsoni. Trout, Lahontan cutthroat...

Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 792

National Research Council Canada - National Science Library

Karwatka, Mike; Packer, Bonnie

2006-01-01

...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. Scoring Records have been coordinated by Mike Karwatka and the Standardized UXO Technology Demonstration Site Scoring Committee...

Standardized UXO Technology Demonstration Site, Open Field Scoring Record No. 770. Magnetometer FEREX DLG GPS/Sling

National Research Council Canada - National Science Library

Karwatka, Mike; Packer, Bonnie

2006-01-01

...) utilizing the YPG Standardized UXO Technology Demonstration Site open field. Scoring Records have been coordinated by Mike Karwatka and the Standardized UXO Technology Demonstration Site Scoring Committee...

76 FR 4683 - Pesticide Experimental Use Permit; Receipt of Application; Comment Request

Science.gov (United States)

2011-01-26

... telephone number is (703) 305-5805. FOR FURTHER INFORMATION CONTACT: Mike Mendelsohn, Biopesticides and... permits. Dated: January 12, 2011. Keith A. Matthews, Acting Director, Biopesticides and Pollution...

Where Are They Now: Nathalie Walker Moves from Science to Activism and Art Communications | Poster

Science.gov (United States)

Whether it’s in a flowerbed or an art gallery, former Werner H. Kirsten (WHK) student intern Nathalie Walker can’t help but to cause a buzz. Since completing her WHK internship in the summer of 2015, Walker has been attending Loyola University Maryland, where she is striving to make a positive impact on campus.

First ITER Council convened in Cadarache - historic step in the quest for clean Energy 28 November 2007 Cadarache

CERN Multimedia

Hay, Jennifer

2007-01-01

"On 27 November 2007, the ITER Council convened for the first time in the history of the new International Organization. Opening the meeting, Dr Werner Burkart, Deputy Director of the International Atomic Energy Agency (AIEA), said: "Let me congratulate all who have contributed to the achievements of the ITER initiative to date.... (1,5 page)

Short Communications A re-evaluation of the taxonomic status of ...

African Journals Online (AJOL)

1990-06-05

Jun 5, 1990 ... X. b. var. linea/US. Roux, 1907 was found to differ sufficiently from typical bieolor to allow subspecific status (FitzSimons 1946). In. 1915, Werner described Micaela pernasUla, later placed in the genus Xenoealamus by Hewitt (1926) and treated as X. b. pernasutus by FitzSimons (1946; 1962) and Witte &.

EKL osales AIAP/IAA Ida- ja Lääne-Euroopa komitee taasasutamiskonverentsil / Jaan Elken

Index Scriptorium Estoniae

Elken, Jaan, 1954-

2001-01-01

21.-23. IX toimus Bratislavas AIAP/IAA (Association Internationale des Arts Plastiques - AIAP UNESCO) Euroopa komitee taasasutamiskonverents. Ida-Euroopa komitee juhatuse presidendiks valiti Mehmet Gyleryuz, Lääne-Euroopa komitee presidendiks Werner Schaub. Euroopa IAA kongress toimub Heidelbergis mais 2002 (kaasneval portreenäitusel esindavad Eestit Mall Nukke, Maria-Kristiina Ulas), maailmakongress Ateenas septembris 2002.

The mismanagement of customer loyalty / Werner Reinartz, V. Kumar

Index Scriptorium Estoniae

Reinartz, Werner

2004-01-01

Kliendilojaalsuse olemusest, mõõtmisest ja juhtimisest, lojaalsete klientide eelistest ning põhjustest neist loobumiseks. Diagramm ja tabelid: The cost of keeping customers on; Which customers are really profitable; Choosing a loyalty strategy

A memorial of Werner Heisenberg and of ISR inauguration

CERN Multimedia

1983-01-01

After 13 years the exploitation of the Intersecting Storage Rings as a beam-beam collider went to an end. In this last year the demands were very exacting, both in terms of operating time and diversified running conditions (Annual Report 1983 p. 123). Before dismantelement the photographer made a last tour, see photos 8310889X --> 8310667X).

Schostakowitsch. Orchesterlieder (Vol. 2), Neeme Järvi / Werner Pfister

Index Scriptorium Estoniae

Pfister, Werner

1996-01-01

Uuest heliplaadist "Schostakowitsch. Orchesterlieder (Vol. 2): Sechs Romanzen op. 21, Sechs Gedichte op. 143a, Suite auf Verse von Michelangelo Buonarroti op. 145a. Göteborger Sinfoniker, Neeme Järvi". DG CD 447 085-2 (WD: 71'06") DDD

The task of understanding the Gospel traditions: Werner Kelber's ...

African Journals Online (AJOL)

The research of WH Kelber on the Gospel traditions .... promised the parousia of Jesus in connection with the Jewish-Roman war ..... of mind and psychological structures so evident in the Bible are strange to us, as we ..... everyday experience' (Carr 1986: 4; cf also Munz 1977). .... Relevance: Communication and cognition.

The task of understanding the Gospel traditions: Werner Kelber's ...

African Journals Online (AJOL)

The research of WH Kelber on the Gospel traditions have important implications. His main emphases are summarized and certain aspects briefly commended. A critical discussion concerning the aims of interpretation, the issue of conflicting traditions, the immense problem of orality and the interpretation of Mark is ...

The task of understanding the Gospel traditions: Werner Kelber's ...

African Journals Online (AJOL)

between the media worlds of oral speech and writing, Mark is seen as ... conceptualization that comes with the world of writing. ... the effect it has on hearers. ...... definitely not simply be conglomerating masses of information; the adding ...

Ameerika pidu saab läbi / Hans-Werner Sinn

Index Scriptorium Estoniae

Sinn, Hans-Werner, 1948-

2008-01-01

Ilmunud ka: Delovõje Vedomosti 26. märts lk. 33. Jooksevkonto defitsiit, ülemäärane tarbimine ja katteta laenud USA-s on toonud lõpu ebatavaliselt pikale majanduskasvu perioodile maailmamajanduses

Lääne-Euroopa kaotab idale / Hans-Werner Sinn

Index Scriptorium Estoniae

Sinn, Hans-Werner, 1948-

2007-01-01

Ilmunud ka: Molodjozh Estonii 9. märts lk. 8. EL-i laienemine itta tähendab tööjõuturu jaoks seda, et nõudlus kõrgelt kvalifitseeritud Lääne-Euroopa tööjõu järele suureneb, kõigi teiste tööliste järele aga langeb ning kokkuvõttes töökohtade arv Lääne-Euroopas väheneb

Copenhagen, an unexplained encounter

CERN Multimedia

2003-01-01

Why did Werner Heisenberg, a participant in the nuclear research programme of the Third Reich, visit his friend and mentor Niels Bohr in occupied Denmark in September 1941? Was it a deliberate attempt to mislead the allies through talking to Bohr? Or was he really pursuing the utopian goal of halting the race to build the atomic bomb? What the historians have never been able to fully explain is explored in the play "Copenhagen", in which the ghosts of the two great scientists try to fathom why they failed to understand each other all those years ago. "Copenhagen", which has filled theatres in London, New York and Paris, is one of the most successful plays of British author Michael Frayn, also famous for his crime thrillers and comedies. A production of the play in French will be staged at the Théâtre de Carouge from 18th November. Werner Heisenberg and Niels Bohr before World War II.Both CERN and the Association pour l'Histoire des Sciences have associated themselves with the production...

Uued plaadid

Index Scriptorium Estoniae

1999-01-01

Uutest heliplaatidest Ivo Linna & Rock Hotel "Kõva ketas", Hendrik Sal-Saller "1994-1996", Chemical Brothers "Surrender", Mike & The Mechanics "M6", Bomfunk Mc"s "In Stereo", Jamiroquai "Synkronized"

Eesti Asfaldiliidu sügisene Asfaldipäev "Ressursid ja keskkond II" : Sokos Hotel Viru konverentsikeskus 21. november 2007

Index Scriptorium Estoniae

2008-01-01

Ülevaade esinejatest ja ettekannetest. Aleksander Kaldas refereerib ja kommenteerib Mike Ascotti artiklit Ameerika Ühendriikide teedemajanduse olukorrast. Lisaks võrdlevad tabelid Eesti ja USA teedevõrgu tiheduse kohta

Maskeering : uus reaalsus = Camouflage : a New Reality / Jean-Philippe Dore, Urs Keller

Index Scriptorium Estoniae

Dore, Jean-Philippe

2001-01-01

Šveitsi arhitektide Jacques Herzogi ja Pierre de Meuroni ning nende koolkonna - Peter Zumthor, Annette Gigon, Mike Guyer, Valerio Olgiati - "sõnatust" arhitektuurist ja selle sotsiaalsest tähendusest.

Neitsitorni suudab äratada ainult valitsus / Mari Kodres

Index Scriptorium Estoniae

Kodres, Mari

2009-01-01

Taani soovib Tallinna linnamüüri Neitsitorni rentida Taani Kultuuri Instituudile ning oleks valmis Neitsitorni ja Taani Kuninga aia renoveerimiseks raha eraldama. Taani arhitekt Erik Nobel on koostanud eelprojekti, kuid Neitsitorn on seisnud tühjalt kolm aastat ning laguneb ja hallitab. Kinnistut taotleb endale USA-s elav Uno Werner. Neitsitorni lähiajaloost, seotusest loomeisikutega

Student Interns Share the Spirit of Science | Poster

Science.gov (United States)

They came for a science lesson. They left with more. The new Werner H. Kirsten student interns filed into the auditorium in Building 549 to expand their knowledge of fundamental laboratory practices, as part of the Science Skills Boot Camp. A panel of presenters instructed the attendees on skills such as reading scientific papers effectively, practicing proper research ethics,

Lõpp annab tähenduse / Olev Remsu

Index Scriptorium Estoniae

Remsu, Olev, 1947-

2006-01-01

Eesti-Saksa koostööfilm "Kõrini" : stsenaristid Hans-Werner Honert, Thomas Steinke, Valentin Kuik, Peeter Simm : režissöör Peeter Simm : operaator Rein Kotov : helilooja Sven Grünberg : osades Maarja Jakobson, Rasmus Kaljujärv, Heio von Stetten, Thomas Schmauser : Ruut Pictures (Eesti) - Saxonia Film (Saksa) 2005. Lisatud P. Simmi filmograafia lk. 106

Kino kolib suveks õue / Janno Zõbin

Index Scriptorium Estoniae

Zõbin, Janno

2002-01-01

Detsembris toimuvat Pimedate Ööde Filmifestivali laiendatakse ka suvele, et sobivates paikades näidata väärtfilme. Tallinnas Katariina kirikus ja Theatrumis juba näidati K. Kieslowski filmide retrospektiivi. Juunis näidatakse Werner Herzogi filme ning Tallinna Linnaarhiivi siseõues hakkab tegutsema juba traditsiooniks saanud vabaõhukino. Noortefilme näidatakse Nukuteatri hoovis

Browse Title Index

African Journals Online (AJOL)

Items 151 - 200 of 4119 ... Issue, Title. Vol 86, No 2 (1996), A re-evaluation of isotope screening for skeletal metastases in nodenegative breast cancer, Abstract PDF. C.A. Gudgeon, I.D. Werner, D.M. Dent. Vol 104, No 6 (2014), A reflection on the South African Medical Association – past, present and future, Abstract PDF.

Iron from Zealandic bog iron ore -

DEFF Research Database (Denmark)

Lyngstrøm, Henriette Syrach

2011-01-01

og geologiske materiale, metallurgiske analyser og eksperimentel arkæologiske forsøg - konturerne af en jernproduktion med udgangspunkt i den sjællandske myremalm. The frequent application by archaeologists of Werner Christensen’s distribution map for the occurrence of bog iron ore in Denmark (1966...... are sketched of iron production based on bog iron ore from Zealand....

Evaluation and Repair of Concrete Slabs

Science.gov (United States)

1992-01-01

No. S. Oct. 1968. pp. 36-51. 17. Verbeck. George J.. "Mechanisms of Corrosion of Steel in 41. Bennett. E. W., and Dave , N. J.. "Test Performances and...Orville R. Werner Paul H. Karr ’ Robert E3. Philkeo Zenon A. Zielinski Lawrence 1. Knab Mtlos Poltvka Corresponding members Alfred G. Btshara J. P. Lloyd

Additivity properties of a Gaussian channel

International Nuclear Information System (INIS)

Giovannetti, Vittorio; Lloyd, Seth

2004-01-01

The Amosov-Holevo-Werner conjecture implies the additivity of the minimum Renyi entropies at the output of a channel. The conjecture is proven true for all Renyi entropies of integer order greater than two in a class of Gaussian bosonic channel where the input signal is randomly displaced or where it is coupled linearly to an external environment

L΄artiste et ses perceptions: vers une nouvelle théorie de l΄art

Directory of Open Access Journals (Sweden)

Victor Anches

2012-06-01

Full Text Available Review to: Konrad Fiedler, Sur l’origine de l’activité artistique, deuxième édition, traduit par Inès Rotermund, Sarah Schmidt, Werner Uwer, Sacha Zilberfarb, sous la direction de Danièle Cohn, Ileana Parvu. Paris: Editions Rue d’Ulm/Presses de l’Ecole normale supérieure, 2008

Ameerika teatriauhinnad jagatud / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2005-01-01

Ameerika kommertsteatri auhinnad said muusikalid "Spamalot" ja "Valgus Piazzal" ning parima draama preemia Ameerika kirjaniku John Patrick Shanley näidend "Kahtlus". Parima lavastaja Tony sai kuuendat korda Mike Nichols

Plaadid / Immo Mihkelson

Index Scriptorium Estoniae

Mihkelson, Immo, 1959-

2002-01-01

Uutest plaatidest Mike Oldfield "Collection", Compay Segundo "Duets", Sandra "Wheel Of Time", "Spirit Of Africa", Paddy's "Irish Folk", Edwin Collins "Doctor Syntax", Doors "Live in Hollywood", Sonic Youth "Murray Street"

Sealants fight back aginst bacteria.

Science.gov (United States)

Moran, Mike

2008-09-01

Mike Moran, business development manager, Industrial Construction, at Bostik, explains how a range of new sealants increase protection in hospital bathrooms, shower rooms and kitchen facilities against healthcare-acquired infections.

Summary Report for ASC L2 Milestone #4782: Assess Newly Emerging Programming and Memory Models for Advanced Architectures on Integrated Codes

Energy Technology Data Exchange (ETDEWEB)

Neely, J. R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Hornung, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Black, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Robinson, P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2014-09-29

This document serves as a detailed companion to the powerpoint slides presented as part of the ASC L2 milestone review for Integrated Codes milestone #4782 titled “Assess Newly Emerging Programming and Memory Models for Advanced Architectures on Integrated Codes”, due on 9/30/2014, and presented for formal program review on 9/12/2014. The program review committee is represented by Mike Zika (A Program Project Lead for Kull), Brian Pudliner (B Program Project Lead for Ares), Scott Futral (DEG Group Lead in LC), and Mike Glass (Sierra Project Lead at Sandia). This document, along with the presentation materials, and a letter of completion signed by the review committee will act as proof of completion for this milestone.

Fragmentation of delta-diketones by electron impact. Olefin elimination and formation of an enol acetate ion

International Nuclear Information System (INIS)

Morizur, J.P.; Mercier, J.; Casals, P.F.

1985-01-01

Under electron impact delta-diketones lose an olefin. The mechanism and structure of the resulting ion have been established by several techniques: substitution, Mike and Cid spectra and thermochemical data [fr

Puuetega inimesed on väga head töölised / Ülle Lätte

Index Scriptorium Estoniae

Lätte, Ülle, 1955-

2003-01-01

PHARE projekti "Puuetega inimeste tööhõive edendamine" raames külastasid Võisiku Hooldekodu Suurbritannia Koolitus- ja konsultatsioonifirma Churchill & Friend direktor Phil Friend ja liitumiseelne nõunik Mike Buckley

U.S. vice president to meet with Baltic heads of state

Index Scriptorium Estoniae

2017-01-01

Ameerika Ühendriikide asepresident Mike Pence kohtus Tallinna visiidil Balti riikide presidentidega ning Eesti kaitseväe juhataja Riho Terrasega. Asepresident kohtus ka Eestis teenivate NATO lahingugrupi sõjaväelastega

Institute for Advanced Learning and Research names new executive director

OpenAIRE

Virginia Tech News

2008-01-01

Virginia Tech's Institute for Advanced Learning and Research has named Liam E. Leightley as executive director, effective Oct. 6, 2008, according to Mike Henderson, chair of the institute's board of trustees.

Matriarhaalne edasikestmine / Jüri Laulik

Index Scriptorium Estoniae

Laulik, Jüri, 1959-

2008-01-01

12. PÖFFi filmidest: Bernd Böclichi "Kuu ja teised armukesed" ("Der Mond und andere Leibhaber", Saksamaa), Mike Leigh' "Happy-Go-Lucky" (Suurbritannia), Kirill Serebrennikovi "Jüripäev" ("Jurjev den", Venemaa)

Towards Grothendieck constants and LHV models in quantum mechanics

International Nuclear Information System (INIS)

Hua, Bobo; Li, Ming; Zhang, Tinggui; Zhou, Chunqin; Li-Jost, Xianqing; Fei, Shao-Ming

2015-01-01

We adopt a continuous model to estimate the Grothendieck constants. An analytical formula to compute the lower bounds of Grothendieck constants has been explicitly derived for arbitrary orders, which improves previous bounds. Moreover, our lower bound of the Grothendieck constant of order three gives a refined bound of the threshold value for the nonlocality of the two-qubit Werner states. (paper)

75 FR 54116 - Application To Export Electric Energy; Powerex Corp

Science.gov (United States)

2010-09-03

..., Federal power marketing agencies, and other entities within the United States. The existing international... No. EA-171-C. Additional copies are to be filed directly with Mike MacDougal and Karen McDonald...

DESIGN OF GRASS BRIQUETTE MACHINE

African Journals Online (AJOL)

user

E-mail addresses: 1 mike.ajieh@gmail.com, 2 dracigboanugo@yahoo.com, ... machine design was considered for processing biomass of grass origin. The machine operations include pulverization, compaction and extrusion of the briquettes.

logbook: inventing the web

CERN Multimedia

Gillies, James D

2005-01-01

In March 1989, Tim Berners-Lee, a young computer scientist at the European particle physics laboratory CERN sent a memo to his boss, Mike Sendall, with the titel "Information Management: a Proposal" (½ page)

The Connect Effect Building Strong Personal, Professional, and Virtual Networks

CERN Document Server

Dulworth, Michael

2008-01-01

Entrepreneur and executive development expert Mike Dulworth's THE CONNECT EFFECT provides readers with a simple framework and practical tools for developing that crucial competitive advantage: a high-quality personal, professional/organizational and virtual network.

Uued plaadid / Koit Raudsepp

Index Scriptorium Estoniae

Raudsepp, Koit

1999-01-01

Uutest heliplaatidest Borax "Mikrorajon", Mike Oldfield "Guitars", The Phil Collins Big Band "A Hot Night In Paris", Tom Waits "Mule Variations", UnderWorld "Beaucop Fish", INCredible Sound Of Drum"n"Bass Mixed By Goldie

Planta de incineración de residuos - Basilea (Suiza

Directory of Open Access Journals (Sweden)

Suter & Suter, Arquitectos

1971-10-01

Full Text Available A new and extremely efficient incinerating plant has become necessary, to complement the older one, to cater for the rapidly increasing size of Basle, and deal with the large amounts of waste materials, many of them resulting from modern packing systems and heating installations. Recently the first stage in the construction of the new plant has been completed, and the second stage will be finished in 1980. Beyond that date the old plant will be demolished and a final stage will be ready for use in 1985. When completed, the plant will burn about 200,000 tons of waste materials per year.El crecimiento considerable experimentado por la ciudad, el actual sistema de venta, en general, las nuevas instalaciones de calefacción y la prohibición a las fábricas de verter sus residuos en vertederos públicos ha creado la imperiosa necesidad de construir una nueva planta de incineración, con extraordinarias instalaciones y perfecto funcionamiento, que, progresivamente, ha de sustituir a la antigua, sin que ésta deje de funcionar, a fin de no crear nuevos problemas. Recientemente ha sido terminada la primera etapa; la segunda se acabará hacia 1980; después de la cual se demolerá la vieja fábrica y se acometerá la última fase, que será finalizada hacia 1985. En estas fechas, el complejo total quemará más de 200.000 t de desechos por año.

PREFACE: Introductory remarks Introductory remarks

Science.gov (United States)

Bowler, D. R.; Alfe, D.

2010-02-01

This special issue contains papers related to the 2009 Thomas Young Centre Workshop at University College London 'Accessing large length and time scales with accurate quantum methods', in celebration of Professor Michael Gillan's 65th birthday. Mike Gillan won the 2006 Institute of Physics Dirac Medal and Prize, the citation reading: 'For his contributions to the development of atomic-scale computer simulations, which have greatly extended their power and effectiveness over an immense range of applications'. This rightly highlights Mike's seminal work on materials modelling, but misses out some of the many other areas he has enriched. After taking his PhD at the Department of Theoretical Physics, Oxford University, Mike went as a post-doc to Minneapolis. He then joined the Statistical Physics Group in the Theoretical Physics Division, Harwell, where he stayed for over 20 years, with a brief interlude in Saclay. In the late 1980s, Mike made a transition to become Professor of Physics at the University of Keele, where he stayed for a decade until University College London was fortunate in being able to tempt him to join the Condensed Matter and Material Physics Group, where there was already a significant materials modelling initiative. Over the years, Mike has made many important contributions, some with impact on other areas of science, others with significance in technology areas such as nuclear safety. Thus, he developed a form of quantum transition-state theory, generalizing Eyring's well-known classical transition-state theory to the case of quantum particles, such as hydrogen, diffusing in condensed matter. He pioneered quantum methods for calculating defect energetics in solids, and then molecular processes on surfaces. He synthesised these approaches into very general ways to calculate thermodynamic free energies of condensed matter from first principles, drawing on his early experience of statistical physics. These methods led to rapid advances in the study

Plaadid / Mart Normet

Index Scriptorium Estoniae

Normet, Mart, 1979-

2005-01-01

Uute heliplaatide Depeche Mode "Playing The Angel", King, B. B. "80", Ray Charles"Genius & Friends", /Queen, PaulRodgers "Return Of The Champions", Sugababes "Taller in More Ways", Kelly Clarkson ""Breakaway, Mike Oldfield "Light and Shade"

Environmental Assessment for Building 88 Interior Demolition, Pearl Harbor Naval Complex, O'ahu, Hawaii

National Research Council Canada - National Science Library

2005-01-01

...) and ancillary equipment from the interior of Building 88, a former lubricating oil storage facility, and the related exposed piping underneath Mike wharves M3 and M4 at Merry Point, Pearl Harbor Naval Complex...

The Ethical Use of Evidence in Biomedicine.

Science.gov (United States)

Pellegrino, Edmund D.

1999-01-01

Examines the ethics of data collection and dissemination, suggesting criteria for the morally responsible treatment of evidence collection, dissemination, and use. Comments on the importance of V. Mike's proposal of an "ethics of evidence." (SLD)

Quanta 3

International Nuclear Information System (INIS)

Kleinknecht, Konrad

2015-01-01

''Quanta 3'' contains the speeches of the general assembly of the Heisenberg society in october 2014 and a speech of Werner Heisenberg about his talks with Albert Einstein, which he has hold in the year 1974 in the Einstein House in Ulm. The speech of Harald Lesch is dedicated to the question, which role plays quantum mechanics in the development of the Universe. In the second speech Karl Jacobs, one of the leading scientists in the ATLAS experiment at CERN, the discovery of the Higgs boson. The Heisenberg Society is dedicated to the mediation of the mental heritage of Werner Heisenberg. He was one of the most important scientists of the 20th century. With his quantum mechanics he opened for us the world of the smallest components of matter, the atoms,nuclei, and elementary particles. It makes also possible the description of the physical properties of molecules, chemical compounds, crystals, solids, and semiconductors and is so the base of the contemporary computer techniques. Heisenberg's discovery of the uncertainty relation has far reaching consequences for natural philosophy ant theory of knowledge and for the development of the cosmos.

DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonuclease

Energy Technology Data Exchange (ETDEWEB)

Ahn, Byungchan, E-mail: bbccahn@mail.ulsan.ac.kr [Department of Life Sciences, University of Ulsan, Ulsan (Korea, Republic of); Bohr, Vilhelm A. [Laboratory of Molecular Gerontology, Biomedical Research Center, National Institute on Aging, Baltimore, MD (United States)

2011-08-12

Highlights: {yields} In this study, we investigated the effect of a DNA secondary structure on the two WRN activities. {yields} We found that a DNA secondary structure of the displaced strand during unwinding stimulates WRN helicase without coordinate action of WRN exonuclease. {yields} These results imply that WRN helicase and exonuclease activities can act independently. -- Abstract: Werner syndrome (WS) is an autosomal recessive premature aging disorder characterized by aging-related phenotypes and genomic instability. WS is caused by mutations in a gene encoding a nuclear protein, Werner syndrome protein (WRN), a member of the RecQ helicase family, that interestingly possesses both helicase and exonuclease activities. Previous studies have shown that the two activities act in concert on a single substrate. We investigated the effect of a DNA secondary structure on the two WRN activities and found that a DNA secondary structure of the displaced strand during unwinding stimulates WRN helicase without coordinate action of WRN exonuclease. These results imply that WRN helicase and exonuclease activities can act independently, and we propose that the uncoordinated action may be relevant to the in vivo activity of WRN.

Briti valitsus usub USA mõjutamise võimalusse / Maris Lillak

Index Scriptorium Estoniae

Lillak, Maris, 1970-

2004-01-01

Suurbritannia endiste kõrgete diplomaatide kirjast, milles nad kritiseerivad peaminister Tony Blairi lähedasi suhteid USA presidendi George W. Bushiga seoses Iraagi ja Iisraeli poliitikaga. Briti välisministeeriumi ministri Mike O'Brien'i vastusest

Absorption of high-dose enteral vitamin A in low- birth-weight ...

African Journals Online (AJOL)

essential for epithelial cell differentiation, it is hypothesised ... produce maximum benefits. As a dose of 50 000 ... injections in such tiny infants has many disadvantages,. inclUding .... Mike Brown, Roche Products, South Africa for the generous.

CHIPS. Volume 29, Issue 1, January - March 2011

Science.gov (United States)

2011-03-01

SPAWARSYSCEN Atlantic ___________________________________________ Columnists Sharon Anderson, Terry Halvorsen, Mike Hernon, Tom Kidd, Steve Muck...that users need. might be changes to the IP officer page. Additionally, pages should have Really Simple Syndication (RSS) feeds. An RSS feed

MIKE-SHE integrated groundwater and surface water model used to ...

African Journals Online (AJOL)

2016-07-03

Jul 3, 2016 ... for Arid Rivers (DRIFT-ARID) decision support system (DSS). The DRIFT-ARID ... Most methods start with a description of the present day (PD) and ... or coupled groundwater and surface water hydrological model to produce a ...

Mike O’Callaghan Federal Medical Center Campus Environmental Assessment

Science.gov (United States)

2012-03-01

and therefore is protected under the Endangered Species Act (ESA). The western burrowing owl (Athene cunicularia) is a former USFWS C- 2 species and...JVanHavel@dot . state . nv.us> ; keiba.crear@snwa.com; LANGSTON@ClarkCountyNV. gov; ~arry . Tamashiro@ lvvwd. com <mailto : Larry . Tamashi! r o@lvvwd...Wardlaw; JVanHavel @dot .state.nv .us; keiba . c rear@snwa . com; Rodney Langston; Larry . Tamashiro@l vvwd.com; laura. j a cobsen@lvvwd . com

Uudiseid maailmast / Nele-Eva Steinfeld

Index Scriptorium Estoniae

Steinfeld, Nele-Eva

2012-01-01

Lühisõnumeid muusikamaailmast: Suri maailma vanim helilooja Elliott Carter. Lahkus Hans Werner Henze. Uusi teoseid Beethovenilt. Joseph Joachimi viiuldajate konkursi võitjad selgunud. Pianist Pavel Kolesnikov võitis Esther Honensi nimelise konkursi. Lõuna-Korea ringhäälingu sümfooniaorkestri uueks peadirigendiks saab Mihhail Pletnjov. Tokyo sümfooniaorkestri uueks muusikajuhis sai Jonathan Nott. Pikendatakse Alan Gilbert'i lepingut. Robert Schumanni auhind

Student Intern Ben Freed Competes as Finalist in Intel STS Competition, Three Other Interns Named Semifinalists | Poster

Science.gov (United States)

By Ashley DeVine, Staff Writer Werner H. Kirstin (WHK) student intern Ben Freed was one of 40 finalists to compete in the Intel Science Talent Search (STS) in Washington, DC, in March. “It was seven intense days of interacting with amazing judges and incredibly smart and interesting students. We met President Obama, and then the MIT astronomy lab named minor planets after each

Details of Nazis' A-Bomb program surface

CERN Multimedia

Glanz, J

2002-01-01

Werner Heisenberg, leader of the Nazi atomic bomb program, revealed the projects existence to Niels Bohr in a meeting in Copenhagen in 1941. But contrary to several historical accounts of the meeting, Heisenberg never expressed moral qualms about building a bomb for Hitler nor hinted that he might be willing to sabotage the project, according to secret documents cited in a London newspaper yesterday (2 pages).

Drainage percutané de l'abcès du psoas: Notre expérience et revue ...

African Journals Online (AJOL)

M. Asseban

et al. Les abcès pyogènes secondaires du psoas: à propos de six cas et revue de la littérature. Rev Med Interne 2006;27:828–35. [3] Muttarak M, Peh WC. CT of unusual iliopsoas compartment lesions. Radiographics 2000. Oct; 20 Spec No: S53-S66. [4] Zissin R, Gayer G, Kots E, Werner M, Shapiro-Feinberg M, Hertz M.

Wave-Particle Dualism in Action

Science.gov (United States)

Schleich, Wolfgang P.

The wave-particle dualism, that is the wave nature of particles and the particle nature of light together with the uncertainty relation of Werner Heisenberg and the principle of complementarity formulated by Niels Bohr represent pillars of quantum theory. We provide an introduction into these fascinating yet strange aspects of the microscopic world and summarize key experiments confirming these concepts so alien to our daily life.

Probing the pre-reactive a Cl (2P) + H2(D2) Van der Waals well through the photodetachment spectroscopy of Cl- H2(D2). CP-31

International Nuclear Information System (INIS)

Ghosal, Subhas; Mahapatra, Susanta

2004-01-01

The photodetachment spectrum of ClH 2 - and ClD 2 , probing the van der Waals well region of the reactive Cl( 2 P) + H 2 (D 2 ) potential energy surface, is theoretically calculated and compared with the experiment. A time-dependent wave packet approach is employed using the Capecchi-Werner coupled multi-sheeted ab initio potential energy surfaces of neutral ClH 2 for this purpose

Modeling Interpersonal Trust in Distributed Command and Control Teams

Science.gov (United States)

2010-06-01

Whitener , Brodt, Korsgaard, & Werner, 1998). Confidence in the trust judgment may also play a role, and could perhaps be moderated by factors such as...this context is complicated , requiring consideration of multiple objects of trust, integration of diverse behavioral research findings, and...2009. Arlington, VA: Offices of Inspector General, Special Inspector General for Iraq Reconstruction. Whitener , E. M., Brodt, S. E., Korsgaard, M. A

Challenging the Application of PMESII-PT in a Complex Environment

Science.gov (United States)

2010-05-21

presentation of the counterintuitive nature of sports teams in regard to cooperation and competition. Every sports team has within it a mixture of...Second, the holistic approach will employ the art of iterative metaquestioning rather than linear answering. Abstract Dimensions: Facets for...article responding to Flavell’s thoughts on metacognition, Werner Feibel, a colleague of Flavell, 216Colonel Stefan J. Banach. “The Art of Design

Circulatory Shock. Volume 34. Number 1. May 1991. International Conference on Shock (2nd), Meeting of European Shock Society (5th), Annual Meeting of the Shock Society (USA) (14th), Vienna Shock Form (3rd) Held in Vienna, Austria on 2-6 June 1991

Science.gov (United States)

1991-06-06

OCTADECENOATE, AS A BURN TOXIN Takayuki Ozawa, Mika Hayakawa, Kazuhiro Kosaka, Satoru Sugiyama, Kazuhisa Yokoo, Hisashi Aoyama, and Yohei Izawa Department...shock. 41 CARDIOPULMONARY HEMODYNAMIC AND PERIPHERAL CIRCULATORY RESPONSES IN SHOCK T. Muteki, N. Kaku. T. Fukushige, I. Kohno and T. Hiraki Department...Tadashi, 242 Machleidt, Werner, 213 Ozawa, Takayuki , 11 Kawarada, Yoshifumi, 442 Mackie, D.P., 348 Ozawa, Kazue, 268 Keser, Claudia, 380 Maitra, Subir R

Students Share Their Research at Student Poster Day | Poster

Science.gov (United States)

Students Share Their Research at Student Poster Day  By Ashley DeVine, Staff Writer More than 50 Werner H. Kirsten student interns and college interns presented their research at Summer Student Poster Day on August 6 in the Building 549 lobby.  Joseph Bergman, a high school intern in the Center for Cancer Research Nanobiology Laboratory, participated in the event “for the

WHK Student Internship Enrollment, Mentor Participation Up More than 50 Percent | Poster

Science.gov (United States)

By Nancy Parrish, Staff Writer The Werner H. Kirsten Student Internship Program (WHK SIP) has enrolled the largest class ever for the 2013–2014 academic year, with 66 students and 50 mentors. This enrollment reflects a 53 percent increase in students and a 56 percent increase in mentors, compared to 2012–2013 (43 students and 32 mentors), according to Julie Hartman, WHK SIP

Prospects for Research in Transport and Logistics on a Regional: Global Perspective (I: February 2009: İstanbul: Turkey)

OpenAIRE

Ülengin, Füsun

2009-01-01

Committees, i -- Words of Welcome and Gratitude, ii -- Introduction, iii -- Chapter 1 Global Issues in Logistics and Transportation, 1 -- Potential to Reduce GHG through Efficient Logistic Concepts, 3 -- Werner Rothengatter -- A methodological framework for the evaluation and prioritisation of multinational transport projects: the Case of euro-asian transport linkages, 21 / Dimitrios TSAMBOULAS, Angeliki KOPSACHEILI -- Container port throughput performance - case study: Far east, north west e...

Ljubov vtoroi svezhesti / Katja Tarhanova

Index Scriptorium Estoniae

Tarhanova, Katja

2005-01-01

Kaks uut ameerika melodraamat - "Oleks see ometi nii" ("Just Like Heaven") : režissöör Mike Waters : peaosas Reese Witherspoon ja "Prime" : stsenarist ja režissöör Ben Younger : peaosas Uma Thurman

Daily MUR SST, Interim near-real-time (nrt) product

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — A daily, global Sea Surface Temperature (SST) data set is produced at 1-km (MUR, or Multi-scale ultra-high resolution Temperature) by the JPL sciengists Drs. Mike...

Asthma education

African Journals Online (AJOL)

2011-01-01

). Allergy and Asthma Clinic, Red Cross War Memorial Hospital. Mike Levin runs a secondary level asthma/ allergy clinic and does a tertiary allergy session once a week, focusing on difficult asthma and food allergies. He has ...

ORIGINAL ARTICLES

African Journals Online (AJOL)

most common presenting complaint being vaginal bleeding. Three of the 5 ... the uterine cervix are rare, unusual and highly aggressive tumours with Jess than SO .... and Messrs Mike. Lanesman and Guy Hall for the photomicrography, and Mr.

Plaadid / Margus Kiis

Index Scriptorium Estoniae

Kiis, Margus

2002-01-01

Uutest plaatidest Nightlight Dou "La Fiesta Del Sol", Yves Montand "Ses Plus Grands Succes", Natalia Oreiro "Tu veneno", Daishin Kashimoto "Passionata", Mike Oldfield "Tres Lunas", Ali G Indiahouse "Da Soundtrack", Ronan Keating "Destination", Roger Waters "Flickering Flame"

Florence Nightingale would have taken on the political fight, and so should we.

Science.gov (United States)

Owen, Michael

2016-05-11

I agree with Mike Travis' comments (letters April 20) about the role and responsibilities of the trade union movement, and those of the RCN in caring for and fighting politically on behalf of nurses at all levels.

Inelastic near-surface interactions. Proceedings of the Werner Brandt workshop

International Nuclear Information System (INIS)

1985-04-01

This workshop is one of an annual series covering penetration phenomena of charged particles in matter. This specific workshop includes electron scattering, ion and atom scattering, stopping powers, and cluster ion impacts on solids. Abstracts were prepared for individual items in the proceedings for inclusion in the data base

Werner Hüllen. English Dictionaries 800–1700: The Topical ...

African Journals Online (AJOL)

rbr

Monographs attempting to treat the history of English dictionaries have to restrict their .... learning, but contemporary learners have printed books and note-paper to ..... His 'scientific' principle was to include all the synonyms in the language.

Saksamaa, immigrantide maa? / Hans-Werner Sinn ; tõlk. Villu Zirnask

Index Scriptorium Estoniae

Sinn, Hans-Werner, 1948-

2006-01-01

Autori sõnul on massiimmigratsioon Saksamaale kestnud juba mitu aastakümmet ning ei peatu ka järgmistel aastakümnetel. Saksamaa peab aga ümber hindama oma sotsiaalse mudeli ja sobitama selle massiimmigratsiooniga. Tabel: Rahvaarv ja immigrantide arv mõnedes maailma riikides

Dostizhenija nemetskihh rabotshihh / Hans-Werner Sinn ; tõlk. Irina Sashtshenkova

Index Scriptorium Estoniae

Sinn, Hans-Werner, 1948-

2007-01-01

Ilmunud ka: Äripäev, 17. sept. 2007, lk. 35. Autor analüüsib Saksamaa seniseid streigikogemusi, rongijuhtide streigiga tekkinud uut olukorda, ametiühingute tegevust ja võimalikke muutusi saksa ametiühinguliikumises

Tööaja pikendamine oli õige otsus / Hans-Werner Sinn

Index Scriptorium Estoniae

Sinn, Hans-Werner, 1948-

2005-01-01

Ilmunud ka: Molodjozh Estonii 29. märts lk. 9. Prantsusmaa otsus lubada tööandjatel suurendada töötundide arvu ja palka tähistab 35-tunnise töönädala likvideerimise algust Euroopas. Suur tööpuuduse tase ning elatustaseme aeglane tõus sunnivad eurooplasi kauem töötama. Muudatustest Saksamaal. Tööaja pikenemise mõjust riigi majanduslikule arengule

EL pakub sisserändajaile heldelt toetusi / Hans-Werner Sinn

Index Scriptorium Estoniae

Sinn, Hans-Werner, 1948-

2006-01-01

Alates 1. maist 2006 kooskõlastasid liikmesriigid oma migratsiooniseadused Euroopa Liidu vaba liikumise direktiiviga, millega garanteeritakse immigrantidele ka sotsiaaltoetused; autori hinnangul viib see Lääne-Euroopa heaoluriikide lagunemiseni

Saksamaal tõstab pead viha kapitalismi vastu / Hans-Werner Sinn

Index Scriptorium Estoniae

Sinn, Hans-Werner, 1948-

2005-01-01

Ilmunud ka: Delovõje Vedomosti 29. juuni lk. 8. Olukorrast Saksamaa majanduses, mis on suurtes raskustes, tööpuudus on jõudnud rekordtasemele. Paljude ettevõtete tootmistegevuse organiseerimine väljaspool emamaad kogub rohkesti kriitikat kapitalismi vastu.

New Primary Dew-Point Generators at HMI/FSB-LPM in the Range from -70 °C to +60 °C

Science.gov (United States)

Zvizdic, Davor; Heinonen, Martti; Sestan, Danijel

2012-09-01

To extend the dew-point range and to improve the uncertainties of the humidity scale realization at HMI/FSB-LPM, new primary low- and high-range dew-point generators were developed and implemented in cooperation with MIKES, in 2009 through EUROMET Project No. 912. The low-range saturator is designed for primary realization of the dew-point temperature scale from -70 °C to + 5 °C, while the high-range saturator covers the range from 1 °C to 60 °C. The system is designed as a single-pressure, single-pass dew-point generator. MIKES designed and constructed both the saturators to be implemented in dew-point calibration systems at LPM. The LPM took care of purchasing and adapting liquid baths, of implementing the temperature and pressure measurement equipment appropriate for use in the systems, and development of gas preparation and flow control systems as well as of the computer-based automated data acquisition. The principle and the design of the generator are described in detail and schematically depicted. The tests were performed at MIKES to investigate how close both the saturators are to an ideal saturator. Results of the tests show that both the saturators are efficient enough for a primary realization of the dew-point temperature scale from -70 °C to + 60 °C, in the specified flow-rate ranges. The estimated standard uncertainties due to the non-ideal saturation efficiency are between 0.02 °C and 0.05 °C.

Carbapenemase-producing Organism in Food

Centers for Disease Control (CDC) Podcasts

2014-08-06

Dr. Mike Miller reads an abridged version of the article, Carbapenemase-producing Organism in Food.  Created: 8/6/2014 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 8/13/2014.

Assessment of storm surge disaster potential for the Andaman Islands

Digital Repository Service at National Institute of Oceanography (India)

Kumar, V.S.; RameshBabu, V.; Babu, M.T.; Dhinakaran, G.; Rajamanickam, G.V.

. Supporting volume 1: math- ematical modelling of cyclone surge and related flooding. In: Cy- clone Damage in Bangladesh. United Nations Centre for Regional Development, pp. 9–37. DHI (Danish Hydraulic Institute), 2002. MIKE 21 Coastal Hydrau- lics...

Garri Potter povzroslel! / Daniel Radcliffe, Emma Watson ; interv. Stass Tõrkin

Index Scriptorium Estoniae

Radcliffe, Daniel, 1989-

2005-01-01

Peaosatäitja järjekorras neljandas Potteri ekraniseeringus "Harry Potter ja tulepeeker" endast, oma tegelaskuju arengust. Samas ka lühiintervjuu näitlejanna Emma Watsoniga. Režissöör Mike Newell : Suurbritannia-USA 2005

Raamat või film? / Lauri Birkan

Index Scriptorium Estoniae

Birkan, Lauri

2005-01-01

Harri Potteri fänn süüvib neljanda J.K. Rowlingu Potteri raamatu ekraniseeringusse "Harry Potter ja tulepeeker" ("Harry Potter and the Goblet of Fire") : režissöör Mike Newell : Suurbritannia-USA 2005

BOD-DO modeling and water quality analysis of a waste water outfall off Kochi, west coast of India

Digital Repository Service at National Institute of Oceanography (India)

Babu, M.T.; Das, V.K.; Vethamony, P.

Water quality scenarios around an offshore outfall off Kochi were simulated using MIKE21 water quality model, assuming a high Biochemical Oxygen Demand (BOD=50 mgl sup(-1)) effluent discharge. The discharge is introduced into the model through...

White House

Science.gov (United States)

... content Jump to navigation the WHITE HOUSE President Donald J. Trump Get in Touch Home Briefing Room From the ... For All Americans The Administration The Administration President Donald J. Trump Vice President Mike Pence First Lady Melania Trump ...

Modelling of stormwater infiltration for stream restoration. Beder (Aarhus) case study

DEFF Research Database (Denmark)

Locatelli, Luca; Bockhorn, Britta; Klint, K. E.

to assess the impact of stormwater runoff infiltration on (1) the water balance; (2) stream flow of the local stream Hovedgrøften; and (3) the risk of polluting the primary aquifer. The hydrogeological model was developed in a deterministic groundwater model (MIKE SHE) which was coupled dynamically...... carried out by developing a hydrogeological model of the Beder area in Aarhus, Denmark. The model area is characterized by the presence of a secondary unconfined aquifer that partly contributes baseflow to the local streams and partly to recharge to the underlying primary aquifer. The model was applied...... to a hydrodynamic 1-D river model (MIKE 11). Geological data based on spear mapping, geophysical data and lithology from local boreholes were used to set up the geological model. Groundwater observation and stream flow measurements were used for model calibration and validation.Different scenarios were analyzed...

Freshwater discharge and sediment transport to Kangerlussuaq Fjord, West Greenland

DEFF Research Database (Denmark)

Mikkelsen, Andreas Peter Bech

the deep inner basin of Kangerlussuaq Fjord. Different melt models were applied to the MIKE SHE and MIKE 11 water routing models in order to simulate the proglacial water flows. The best melt model was a surface energy balance model. The routing model improved the modelled proglacial discharge......The main objectives of this PhD study have been to quantify the large-scale hydrological and geomorphological processes and implications related to three large proglacial rivers draining into Kangerlussuaq Fjord from the Greenland Ice Sheet (GrIS). These rivers are Watson, Umivit and Sarfartoq...... River. Hydrological processes studied are: proglacial discharge volumes and timing of this, creation of runoff (i.e. melt), storage and release features such as ice dammed lakes (jökulhlaups lakes), the role of supraglacial lakes, storage and release inside or beneath the ice and the role of the so...

AJOL

African Journals Online (AJOL)

Radiobiology and Medical Physics Departments. The books ... Mary Thomas gives a brief but balanced account of his life and work ... time, the study of pain at the level of the gene, using transgenic ... Kevin Mackway-Jones and Mike Walker.

CrossTalk: The Journal of Defense Software Engineering. Volume 20, Number 2

National Research Council Canada - National Science Library

Phillips, Mike; Craig, Rushby; Jackelen, George; Humphrey, Watts S; Konrad, Michael D; Over, James W; Pries-Heje, Jan; Johansen, Joern; Christiansen, Mads; Korsaa, Morten; Laporte, Claude Y; April, Alain; Renault, Alain

2007-01-01

CONTENTS: 1) CMMI V1.2: What Has Changed and Why by Mike Phillips: This article provides a view of what has been included - and not included - in Capability Maturity Model Integration Version 1.2 (CMMI V1.2...

2018-05-08T23:52:20Z https://www.ajol.info/index.php/all/oai oai:ojs ...

African Journals Online (AJOL)

article/15137 2018-05-08T23:52:20Z ajb:ART Indigenous Angiosperm biodiversity of Olabisi Onabanjo University permanent site Soladoye, Mike O; Department of Plant Sciences and Applied Zoology, Olabisi Onabanjo University, P.M.B. 2002, ...

Myrtle Beach Air Force Base Community Redevelopment Plan

Science.gov (United States)

1993-01-01

Chairperson Economic Development: Harold Tadlock Bill Benson Don Leonard Craig Wall Education & Training: Kent Sharples , Chairperson Dick Rosen Doug...Airport: Ralph Panzrino. Chairperson Mike Leahy Betty Martin Eugene Dorman, Chairperson Jessie Ward Donald Hardee Gene Stroman Bill Brown David

Outbreaks of Kingella kingae Infections in Daycare Facilities

Centers for Disease Control (CDC) Podcasts

2014-05-06

Dr. Mike Miller reads an abridged version of the synopsis, Outbreaks of Kingella kingae Infections in Daycare Facilities.  Created: 5/6/2014 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 5/7/2014.

Deaths Attributable to Carbapenem-Resistant Enterobacteriaceae Infections

Centers for Disease Control (CDC) Podcasts

2014-08-06

Dr. Mike Miller reads an abridged version of the article, Deaths Attributable to Carbapenem-Resistant Enterobacteriaceae Infections.  Created: 8/6/2014 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 8/13/2014.

Sandia National Laboratories: About Sandia: Leadership

Science.gov (United States)

Locations Contact Us Employee Locator Search Menu About Leadership Mission Social Media Community ; Culture Work-Life Balance Special Programs History Leadership Mission Environmental Responsibility Flickr RSS Top Leadership Stephen Younger David Douglass Scott Aeilts Doug Bruder Mike Burns John Clymo

Coastal circulation off Ratnagiri, west coast of India during monsoon seasons: a numerical model study.

Digital Repository Service at National Institute of Oceanography (India)

Samiksha, S.V.; Sharif, J.; Vethamony, P.

Present study is the coastal circulation modelling off Ratnagiri under the influence of winds and tides. A two-dimensional hydrodynamic model MIKE 21HD has been used to simulate tides and currents, and model results are in a good agreement...

77 FR 62537 - Notice of Waste Management Permit Application Received Under the Antarctic Conservation Act of 1978

Science.gov (United States)

2012-10-15

... NATIONAL SCIENCE FOUNDATION Notice of Waste Management Permit Application Received Under the Antarctic Conservation Act of 1978 AGENCY: National Science Foundation. ACTION: Notice of a Waste Management... the National Science Foundation (NSF) has received a waste management permit application for Mike...

PERFORMANCE EVALUATION AND PARAMETERS SENSITIVITY ...

Indian Academy of Sciences (India)

86

wetland (242.21 km2), Malaysia using MIKE SHE distributed model while coupling ..... the ponding water which may lead to rise in the water table level. ..... catchment; and Ds = 2.09 mm represents the amount of depression storages over the ...

Knemidocoptic Mange in Wild Golden Eagles, California, USA

Centers for Disease Control (CDC) Podcasts

2014-09-21

Dr. Mike Miller reads an abridged version of the article, Knemidocoptic Mange in Wild Golden Eagles, California, USA .  Created: 9/21/2014 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 10/15/2014.

Filmimaailma aplaus realismile : kolmas festivalikiri Cannes'ist, kus filmiprogramm on ületanud ekvaatori / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2002-01-01

Kolmest seni huvitavamast filmist : inglase Mike Leigh' "Kõik või ei midagi", Michiganist pärit dokumentalisti Michael Moore'i ameeriklaste vägivaldsust uuriv "Keeglimäng enne Columbine'i", iraanlase Abbas Kiarostami "10" ja Kanada armeenlase Atom Egoyani "Ararat"

Jane Austen ja viktoriaanluse come back / Mihkel Mutt

Index Scriptorium Estoniae

Mutt, Mihkel, 1953-

1996-01-01

Jane Austeni teoste jätkuvalt kasvavast populaarsusest, raamatute põhjal lavastatud filmidest, viktoriaanlusest ja muust - inspireerituna filmist "Neli pulma ja üks matus" ("Four Weddings and a Funeral", rež̓issöör Mike Newell, Suurbritannia 1994)

Videokunsti parimad stiilinäited Kumus

Index Scriptorium Estoniae

2010-01-01

Kumu Kunstimuuseumis avatakse 28. oktoobril 2010 rahvusvaheline videokunsti näitus "Kõik saab korda". Osalevad Marina Abramović (Serbia/USA), Eija-Liisa Ahtila (Soome), Kai Kaljo, Mike Marshall (Inglismaa), Ene-Liis Semper, Santeri Tuori (Soome), Guido van der Werve (Holland)

A Lean Approach to Scheduling Systems Engineering Resources

Science.gov (United States)

2013-05-01

Boeing), Suzette Johnson (Northrop Grumman), Larry Mac- cherone (Rally Development), Don Reinertsen (Reinertsen & Associates), David Rico (Boe- ing...Change for Your Technology Business. Sequim, WA: Blue Hole Press 9. Burrows , Mike. (2010). Kanban in a Nutshell. Blog post. <http

Ise kaklevad, ise lepivad / Aare Ermel

Index Scriptorium Estoniae

Ermel, Aare, 1957-2013

2001-01-01

Mängufilm "Kes kardab Virginia Woolfi?" ("Who's Afraid Of Virginia Woolf?") : stsenarist Ernest Lehman Edward Albee näidendi järgi : režissöör Mike Nichols : Ameerika Ühendriigid 1966. Ka : Teleleht nr. 11, lk.4

Broadband Monopole Antenna

Science.gov (United States)

2017-09-14

December 2017 The below identified patent application is available for licensing. Requests for information should be addressed to...CROSS REFERENCE TO OTHER PATENT APPLICATIONS [0002] United States Patent Application Ser. No. 15/220,692 filed on July 27, 2016 is incorporated by...antenna operating near 2.5 GHz to obtain an octave of bandwidth. One solution for this is given by Werner et al. in United States Patent

The German Economy and U.S.-German Economic Relations

Science.gov (United States)

2009-11-30

Should the SPD and The Left overcome existing differences, the grouping could represent a leftward shift in German politics. Alliance ’90 / The...and replaced it with less generous social assistance benefits already available to poor individuals, regardless of employment history . These changes...director at Volkswagen . 48Hans-Werner Sinn, Can Germany Be Saved?, p. 108. 49 Alister Miskimmon and Walter E. Paterson, “Conclusion: coping with the

Watch Out for the Children: Army Policy and Child Soldiers

Science.gov (United States)

2016-06-01

Arbor, MI: Fairfax Press, 1960), 63. 17 Emmy E . Werner, Reluctant Witnesses: Children’s Voices from the Civil War (Boulder, CO: Westview Press, 1998...Soldiers: From Violence to Protection (Cambridge, MA: Harvard University Press, 2006), 20–21. 71 Vera Achvarina and Simon F. Reich, “No Place to Hide...Conflict: Law, Policy and Practice (Leiden, Netherlands: Martinus Nijhoff Publishers, 2005), 23. 86 Tanya Zayed and Svenja Vollmer, E -Learning

Genuine tripartite entangled states with a local hidden-variable model

International Nuclear Information System (INIS)

Toth, Geza; Acin, Antonio

2006-01-01

We present a family of three-qubit quantum states with a basic local hidden-variable model. Any von Neumann measurement can be described by a local model for these states. We show that some of these states are genuine three-partite entangled and also distillable. The generalization for larger dimensions or higher number of parties is also discussed. As a by-product, we present symmetric extensions of two-qubit Werner states

The indeterminability of the world. Heisenberg and the struggle about the soul of the world

International Nuclear Information System (INIS)

Lindley, D.

2008-01-01

With his detection of the so-called uncertainty or undeterminacy relation the young physicist Werner Heisenberg upsetted 1972 over centuries valid physical certainties. The American physicist and journalist David Lindley depicts in his fascinating story the birth and development of one of the most important knowledges of history of sciences, which faned a vehement controversy under the greatests minds of his time and changed deeply our view of the world

Self-compassion and social anxiety in adolescents: a systematic review of the association between shame and social anxiety and an empirical study of the relationship between selfcompassion and social anxiety in adolescents

OpenAIRE

Gill, Ciara Síobhan

2015-01-01

Background: Compassion Focused Therapy aims to reduce shame through the development of compassion towards the self (Gilbert & Proctor, 2006). In a recent meta-analysis, MacBeth & Gumley (2012), identified self-compassion as a good predictor of mental wellbeing in adult populations. In addition, Werner et al (2012) provided preliminary evidence that difficulties with self-compassion may contribute to the development and maintenance of social anxiety. Despite wide recognition tha...

Environmental Perturbations, Behavioral Change, and Population Response in a Long-Term Northern Elephant Seal Study

Science.gov (United States)

2014-09-30

maintain either constant immigration or reproductive rates near 1.0 to maintain stable population growth. IMPACT/APPLICATIONS Using...Costa. 2013. Movement and diving patterns of juvenile male South American sea lions off the coast of central Chile . Marine Mammal Science:n/a-n/a...coast of central Chile . Marine Mammal Science 30:1175-1183. Jeglinski, J. W., K. T. Goetz, C. Werner, D. P. Costa, and F. Trillmich. 2013. Same

Battle Environment Assessment for Commanders: A Concept of Support for Joint and Component Strategy and Operations.

Science.gov (United States)

1988-03-14

focused application of decision aids. These decision aids must incorporate standardized processes, computer assisted artificial intelligence, linkage...Theater Planning. A Strategic-Operational Perspective,’ by COL MIke ,or i n Olesak, John, LTC Office of the Deputy Chief of Staff, Inteligence , U S

Short communications | Mockler | Scopus: Journal of East African ...

African Journals Online (AJOL)

Title: An exceptional gathering of Levant Sparrowhawks Accipiter brevipes in Mara North Conservancy, western Kenya. Author: Mike Mockler. Title: Recent undocumented Kenya records of the Grey-chested Babbler Kakamega poliothorax. Authors: Gladys Kung'u, Titus Imboma, Peter Njoroge. Title: Discovery of a ...

Implicitly-Defined Neural Networks for Sequence Labeling

Science.gov (United States)

2016-09-09

the correct determination. Figure 4: A more common and complicated example. Note the entire clause about ‘Health Care Property Investors Inc...some linguistics? In In- ternational Conference on Intelligent Text Processing and Computational Linguistics, pages 171–189. Springer. Mike Schuster

Pop / Erkki Luuk

Index Scriptorium Estoniae

Luuk, Erkki, 1971-

2003-01-01

Heliplaatidest: Lionel Marchetti "RISS (l'avalanche)", Scooter "The Stadium Techno Experience", Kojak "Every Room On Every Floor", Mike Oldfield "Tubular Bells 2003", Stereophonics "You Gotta Go There To Come Back", Sleepy Sleepers "Kekkonen", M Ward "Transfiguratuon Of Vincent", Molotov "Dance And Dense Denso"

DOT/FAA Human Factors Workshop on Aviation (5th). Transcript.

Science.gov (United States)

1982-01-01

This document is a verbatim transcript of the proceedings of the Fifth Human Factors Workshop held at the Mike Monroney Aeronautical Center in Oklahoma City, Oklahoma, on July 7-9, 1981. The Sixth Human Factors Workshop was held at the same facility ...

DOT/FAA Human Factors Workshop on Aviation (6th). Transcript.

Science.gov (United States)

1982-05-01

This document is a verbatim transcript of the proceedings of the DOT/FAA Sixth Human Factors Workshop on Aviation held at the Mike Monroney Aeronautical Center, Oklahoma City, Oklahoma on July 7-8, 1981. The subject of the workshop was aviation maint...

Hybrid Electric Vehicle Publications | Transportation Research | NREL

Science.gov (United States)

Hybrid Electric Vehicle Publications Hybrid Electric Vehicle Publications The following technical papers, conference papers, and fact sheets provide information about NREL's hybrid electric fleet vehicle Class 8 Hybrid Electric Delivery Trucks. Mike Lammert. (2011) FedEx Delivery Trucks In-Use and Vehicle

Globalisering, forbrugskultur og energi

DEFF Research Database (Denmark)

Rüdiger, Mogens

2004-01-01

In the first part of the article, John Tomlinson's and Mike Featherstone's theoretical discussion of the concepts of homogenisation, de-territorialisation, consumer culture and lifestyle are presented. In order to capture omportant aspects of a consumer culture based on large scale consumption...

Early reionization and its cosmological implications

Indian Academy of Sciences (India)

A proper accounting of this effect would force one towards numerical ... because of the contribution from the complete reionization of 4He → 4He+.) At z = 6.3, new ... The author thanks Mike Chu, Zoltan Haiman, Gil Holder, Lloyd Knox, Mario.

IPDO-2007: Inverse Problems, Design and Optimization Symposium

Science.gov (United States)

2007-08-01

Grebenniko v J. Luna Tomas Perez Manuel Enriquez 025 Alexande r Grebenniko v 026 Tsung- Chien Chen Shou- Jen Hsu Pan-Chio Tuan 028...Dulikravich 086 Helmut Sobieczky Monika Hannemann 087 Anssi Lehikoinen Arto Voutilainen Jari Kaipio Stefan Finsterle Mike Kowalsky 088

Zhutkii Garri Potter

Index Scriptorium Estoniae

2005-01-01

Järjekorras neljas Potteri ekraniseering "Harry Potter ja tulepeeker" ("Harry Potter and the Goblet of Fire") sai oma sünguse tõttu reitingu, mille järgi alla 12. aastased lapsed võivad vaadata filmi vaid koos vanematega. Rezh. Mike Newell

Kernel-Based Approximate Dynamic Programming Using Bellman Residual Elimination

Science.gov (United States)

2010-02-01

Redding, Mike Robbins, Frant Sobolic, Justin Teo, Tuna Toksoz, Glenn Tournier, Aditya Undurti, Mario Valenti, Andy Whitten, Albert Wu, and Rodrigo...vector algorithms. Neural Computation, 12(5):1207–1245, 2000. [143] P. Schweitzer and A. Seidman. Generalized polynomial approximation in Markovian

78 FR 55676 - Notice of Public Meeting of the Illinois Advisory Committee for Fact Finding on Immigrant...

Science.gov (United States)

2013-09-11

... regarding the civil rights implications of the comprehensive immigration reform bill on Illinois' immigrant... could disparately impact categories of individuals or create unequal opportunities. The meeting will... immigration attorney Mike Jarecki, Lisa Palumbo of the Legal Assistance Foundation, DePaul College of Law...

The New Global Health

Centers for Disease Control (CDC) Podcasts

2013-08-13

Dr. Mike Miller reads an abridged version of the Emerging Infectious Diseases’ Perspective, The New Global Health.  Created: 8/13/2013 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 8/14/2013.

A drone flight over ESO’s experimental sites in Chile

CERN Multimedia

CERN Bulletin

2015-01-01

Paola Catapano, a member of CERN’s Communication Group, and Mike Struik, a member of the TE Department, were invited to visit ESO’s experimental sites – the ALMA observatory and the Very Large Telescope in Paranal, Chile. Enjoy some of the beautiful images they sent to the Bulletin.   Image courtesy Paola Catapano and Mike Struik. The 66 radio astronomy antennas of the Atacama Large Millimeter/submillimeter Array (ALMA) observatory at 5,000 m altitude on the Chajnantor highland in Chile. The ALMA array specialises in the cold, invisible Universe, catching radiation from millimetre and submillimetre radiowaves night and day. ALMA is an international partnership between the European Southern Observatory (ESO), the US National Science Foundation (NSF) and the National Institutes of Natural Sciences (NINS) of Japan, together with NRC (Canada), NSC and ASIAA (Taiwan), and KASI (Republic of Korea), in cooperation with the Republic of Chile.   Image cour...

Modelling Interactions between Land Use, Climate, and Hydrology along with Stakeholders’ Negotiation for Water Resources Management

Directory of Open Access Journals (Sweden)

Babak Farjad

2017-11-01

Full Text Available This paper describes the main functionalities of an integrated framework to model the interactions between land use, climate, and hydrology along with stakeholders’ negotiation. Its novelty lies in the combination of individual-based and spatially distributed models within the Socio-Hydrology paradigm to capture the complexity and uncertainty inherent to these systems. It encompasses a land-use/land-cover cellular automata model, an agent-based model used for automated stakeholders’ negotiation, and the hydrological MIKE SHE/MIKE 11 model, which are linked and can be accessed through a web-based interface. It enables users to run simulations to explore a wide range of scenarios related to land development and water resource management while considering the reciprocal influence of human and natural systems. This framework was developed with the involvement of key stakeholders from the initial design stage to the final demonstration and validation.

A relação linguagem, pensamento e ação na microgênese das funções psíquicas superiores

Directory of Open Access Journals (Sweden)

Jairo Werner

2015-04-01

Full Text Available O objetivo deste artigo é demonstrar, de forma concreta, a mediação da fala na constituição das funções psíquicas superiores do sujeito, buscando articular autores da vertente histórico-cultural, como Vigotski,1 com a perspectiva metodológica de Heloisa Marinho, pesquisadora brasileira que centrou na linguagem sua contribuição pioneira no âmbito do desenvolvimento infantil. A metodologia utilizada fundamentou-se no estudo da relação oral-gráfica (MARINHO; WERNER, 1982, em amostra constituída por três mil crianças, foi realizada a análise microgenética-indiciária (WERNER, 1999, 2001 da atividade gráfica de menino de dois anos de idade cronológica, oriundo da creche UFF. Como resultado, foi possível ilustrar como, na vigência de processo de interação-interlocução adulto-criança e criança-crianças, ocorrem transformações qualitativas nas funções psíquicas (microgênese, nas quais a mediação, por meio dos signos da linguagem (mediação semiótica, reveste-se de papel fundante e constitutivo.

Supporting Crop Loss Insurance Policy of Indonesia through Rice Yield Modelling and Forecasting

Science.gov (United States)

van Verseveld, Willem; Weerts, Albrecht; Trambauer, Patricia; de Vries, Sander; Conijn, Sjaak; van Valkengoed, Eric; Hoekman, Dirk; Grondard, Nicolas; Hengsdijk, Huib; Schrevel, Aart; Vlasbloem, Pieter; Klauser, Dominik

2017-04-01

The Government of Indonesia has decided on a crop insurance policy to assist Indonesia's farmers and to boost food security. To support the Indonesian government, the G4INDO project (www.g4indo.org) is developing/constructing an integrated platform implemented in the Delft-FEWS forecasting system (Werner et al., 2013). The integrated platform brings together remote sensed data (both visible and radar) and hydrologic, crop and reservoir modelling and forecasting to improve the modelling and forecasting of rice yield. The hydrological model (wflow_sbm), crop model (wflow_lintul) and reservoir models (RTC-Tools) are coupled on time stepping basis in the OpenStreams framework (see https://github.com/openstreams/wflow) and deployed in the integrated platform to support seasonal forecasting of water availability and crop yield. First we will show the general idea about the G4INDO project, the integrated platform (including Sentinel 1 & 2 data) followed by first (reforecast) results of the coupled models for predicting water availability and crop yield in the Brantas catchment in Java, Indonesia. Werner, M., Schellekens, J., Gijsbers, P., Van Dijk, M., Van den Akker, O. and Heynert K, 2013. The Delft-FEWS flow forecasting system, Environmental Modelling & Software; 40:65-77. DOI: 10.1016/j.envsoft.2012.07.010.

Modelling and Forecasting of Rice Yield in support of Crop Insurance

Science.gov (United States)

Weerts, A.; van Verseveld, W.; Trambauer, P.; de Vries, S.; Conijn, S.; van Valkengoed, E.; Hoekman, D.; Hengsdijk, H.; Schrevel, A.

2016-12-01

The Government of Indonesia has embarked on a policy to bring crop insurance to all of Indonesia's farmers. To support the Indonesian government, the G4INDO project (www.g4indo.org) is developing/constructing an integrated platform for judging and handling insurance claims. The platform consists of bringing together remote sensed data (both visible and radar) and hydrologic and crop modelling and forecasting to improve predictions in one forecasting platform (i.e. Delft-FEWS, Werner et al., 2013). The hydrological model and crop model (LINTUL) are coupled on time stepping basis in the OpenStreams framework (see https://github.com/openstreams/wflow) and deployed in a Delft-FEWS forecasting platform to support seasonal forecasting of water availability and crop yield. First we will show the general idea about the project, the integrated platform (including Sentinel 1 & 2 data) followed by first (reforecast) results of the coupled models for predicting water availability and crop yield in the Brantas catchment in Java, Indonesia. Werner, M., Schellekens, J., Gijsbers, P., Van Dijk, M., Van den Akker, O. and Heynert K, 2013. The Delft-FEWS flow forecasting system, Environmental Modelling & Software; 40:65-77. DOI: 10.1016/j.envsoft.2012.07.010 .

Using Remote Sensing to Identify Changes in Land Use and Sources of Fecal Bacteria to Support a Watershed Transport Model

Directory of Open Access Journals (Sweden)

Sean Butler

2014-07-01

Full Text Available The contamination of shellfish harvesting areas by fecal bacteria in the Annapolis Basin of Nova Scotia, Canada, is a recurring problem which has consequences for industry, government, and local communities. This study contributes to the development of an integrated water quality forecasting system to improve the efficiency and effectiveness of industry management. The proposed integrated forecasting framework is composed of a database containing contamination sources, hydrodynamics of the Annapolis Basin, Escherichia coli (E. coli loadings and watershed hydrology scenarios, coupled with environmental conditions of the region (e.g., temperature, precipitation, evaporation, and ultraviolet light. For integration into this framework, this study presents a viable methodology for assessing the contribution of fecal bacteria originating from a watershed. The proposed methodology investigated the application of high resolution remote sensing, coupled with the commercially available product, MIKE 11, to monitor watershed land use and its impact on water quality. Remote sensing proved to be an extremely useful tool in the identification of sources of fecal bacteria contamination, as well as the detection of land use change over time. Validation of the MIKE 11 model produced very good agreement (R2 = 0.88, E = 0.85 between predicted and observed river flows, while model calibration of E. coli concentrations showed fair agreement (R2 = 0.51 and E = 0.38 between predicted and observed values. A proper evaluation of the MIKE 11 model was constrained due to limited water sampling. However, the model was very effective in predicting times of high contamination for use in the integrated forecasting framework, especially during substantial precipitation events.

The role of van der waals interaction on quantum-mechanical tunneling

Energy Technology Data Exchange (ETDEWEB)

Takayanagi, Toshiyuki; Kurosaki, Yuzuru [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

1998-10-01

We present three-dimensional quantum cumulative reaction probabilities for the F + H{sub 2}, D{sub 2}, and HD reactions with a special emphasis on resonances associated with quasi-bound states localized in the reactant van der Waals region of the potential energy surface. The accurate ab initio potential surface of Stark and Werner and the less accurate 5SEC-W surface developed by Truhlar and co-workers have been employed. (author)

Pathologies des hélicases et vieillissement précoce : modèle d'étude par dérivation de cellules souches pluripotentes induites (iPS)

OpenAIRE

Gatinois , Vincent

2017-01-01

Helicases process the double-stranded DNA dissociation. They are involved in replication, DNA repair and maintenance of telomeres. In human, 3 helicases display mutations responsible for clinical syndromes: WRN for the Werner syndrome, BLM for the Bloom syndrome and RECQL4 for the Rothmund-Thomson syndrome. All these diseases cause premature ageing and high risk of cancer. Molecular and cellular mechanisms involved in these diseases are not well defined. Particularly, little is known concerni...

Conditional discrimination learning: A critique and amplification

OpenAIRE

Schrier, Allan M.; Thompson, Claudia R.

1980-01-01

Carter and Werner recently reviewed the literature on conditional discrimination learning by pigeons, which consists of studies of matching-to-sample and oddity-from-sample. They also discussed three models of such learning: the “multiple-rule” model (learning of stimulus-specific relations), the “configuration” model, and the “single-rule” model (concept learning). Although their treatment of the multiple-rule model, which seems most applicable to the pigeon data, is generally excellent, the...

On $L_p$ Affine Surface Area and Curvature Measures

OpenAIRE

Zhao, Yiming

2015-01-01

The relationship between $L_p$ affine surface area and curvature measures is investigated. As a result, a new representation of the existing notion of $L_p$ affine surface area depending only on curvature measures is derived. Direct proofs of the equivalence between this new representation and those previously known are provided. The proofs show that the new representation is, in a sense, "polar" to that of Lutwak's and "dual" to that of Sch\\"utt & Werner's.

Computer Modeling of Complete IC Fabrication Process.

Science.gov (United States)

1987-05-28

James Shipley National Semi.Peter N. Manos AMD Ritu Shrivastava Cypress Semi. Corp.Deborah D. Maracas Motorola, Inc. Paramjit Singh Rockwell Intl.Sidney...Carl F Daegs Sandia Hishan Z Massoud Duke* UnIVersdy Anant Dix* Silicon Systems David Matthews Hughes Rese~arch Lab DIolidi DoIIos Spery Tmioomly K...Jaczynski AT&T Bell Labs Jack C. Carlson Motorola Sanjay Jain AT&T Bell Labs Andrew Chan Fairchild Weston Systems Werner Juengling AT&T Bell Labs

75 FR 5303 - Tests Determined To Be Suitable for Use in the National Reporting System for Adult Education (NRS)

Science.gov (United States)

2010-02-02

... DEPARTMENT OF EDUCATION Tests Determined To Be Suitable for Use in the National Reporting System for Adult Education (NRS) AGENCY: Office of Vocational and Adult Education, Department of Education.... FOR FURTHER INFORMATION CONTACT: Mike Dean, U.S. Department of Education, 400 Maryland Avenue, SW...

Tracks: A National Environmental Public Health Tracking Network Overview

Centers for Disease Control (CDC) Podcasts

In this podcast, Dr. Mike McGeehin, Director of CDC's Division of Environmental Hazards and Health Effects, provides an overview of the National Environmental Public Health Tracking Network. It highlights the Tracking Network's goal, how it will improve public health, its audience, and much more.

76 FR 60007 - TRICARE Demonstration Project for the Philippines

Science.gov (United States)

2011-09-28

... in the Philippines, controlling costs, eliminating any balance billing issues, and ensuring that the..., Suite 810, Falls Church, VA 22041-3206. FOR FURTHER INFORMATION CONTACT: Mr. Mike Talisnik, Office of.... Administrative controls such as the validation of providers, implementation of a fee reimbursement schedule...

Täna kell 17.30 avatakse Tallinna Kunstihoones briti, eesti ja soome fotonäitus "Fantastiline realism"

Index Scriptorium Estoniae

2004-01-01

Kuraator Eve Kiiler. Osalejad loetletud. Avamisel esineb Naeruorgesster. 28. II seminaril räägib Asko Mäkela soome fotokunstist, David Bate briti fotost, Mike Marshall, Denny Robson, Outi Liusvaara, Marja Pirilä, Kai Kaljo ja Piret Räni presenteerivad oma töid

U.S.-China Military Contacts: Issues for Congress

Science.gov (United States)

2013-07-25

Washington, and New York. Despite the unofficial talks, PACOM Commander (Admiral Tim Keating), Chairman of the Joint Chiefs of Staff (Admiral Mike...led a delegation on military environmental protection matters to the United States. They visited Washington, DC; Fort Pickett in Virginia; Fort Bliss

Stronger Consistency and Semantics for Low-Latency Geo-Replicated Storage

Science.gov (United States)

2013-06-01

Wallach, Mike Burrows , Tushar Chandra, Andrew Fikes, and Robert E. Gruber. Bigtable: A distributed storage system for structured data. ACM TOCS, 26(2...propagation for weakly consistent replication. In SOSP, October 1997. [60] Larry Peterson, Andy Bavier, and Sapan Bhatia. VICCI: A programmable cloud

Trading Freshness for Performance in Distributed Systems

Science.gov (United States)

2014-12-01

C. Hsieh, Deborah A. Wallach, Mike Burrows , Tushar Chandra, Andrew Fikes, and Robert E. Gruber. BigTable: A distributed storage system for structured... Larry Brilliant. Detecting influenza epidemics using search engine query data. Nature, pages 1012–1014, February 2009. 3.2 Goetz Graefe. Write

Electrostatic Charging of Spacecraft in Geosynchronous Orbit

Science.gov (United States)

1992-12-17

cycle variations, the transitions into and out of region I are very sharpl !,, defined, particularly for the higher Kp ranges where the mean boundary...spectrometer data. The electron beam tests would not have possible without the enthusiastic support of Mike Duck of Chemistry Division, Harwell

Biomarker Correlates of Survival in Pediatric Patients with Ebola Virus Disease

Centers for Disease Control (CDC) Podcasts

2014-08-19

Dr. Mike Miller reads an abridged version of the article, Biomarker Correlates of Survival in Pediatric Patients with Ebola Virus Disease.  Created: 8/19/2014 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 8/19/2014.

A synoptic decomposition of rainfall over the Cape south coast of South Africa

CSIR Research Space (South Africa)

Engelbrecht, CJ

2015-05-01

Full Text Available Reviewers: Alice Favre afavre@csag.uct.ac.za Expert in cut-off lows occurring over South Africa Chris Reason chris.reason@uct.ac.za Expert in southern Africa climate variability Michael Pook mike.pook@csiro.au Expert in developing synoptic climatology...

Washington (Wash) C. Winn: In Memoriam

Centers for Disease Control (CDC) Podcasts

2012-03-08

Dr. Mike Miller and Dr. David Walker dicuss the career and life of noted clinical biologist, Dr. Washington C. Winn Jr.  Created: 3/8/2012 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 3/12/2012.

Eesti puukujud Exmoori metsades / Katre Lember

Index Scriptorium Estoniae

Lember, Katre, 1978-

2007-01-01

Exmoori looduspargis töötav Mike Leach on pärast Eestisse puuskulptuuride sümpoosionile sattumist korraldanud analoogilisi üritusi ka Inglismaal - 2004. aastal Porlockis ja 2006. aastal Dunsteris, millest võtsid osa ka eestlased. Lähemalt ka Dunsteri külast ja Exmoori looduspargist

Inimelu võlu ja vaev, rassipuhtus ja koolera / Aare Ermel

Index Scriptorium Estoniae

Ermel, Aare, 1957-2013

2007-01-01

PÖFFi filmidest: "Uus inimene" ("Den nya människan", rezh. Klaus Härö, Soome 2007), "Teie, kes te elate" ("Du levande", rezh. Roy Andersson, Rootsi 2007), "Armastus koolera ajal" ("Love in the Time of Cholera", Gabriel Garcia Marqueze romaani ekraniseering, rezh. Mike Newell, USA 2007)

76 FR 32248 - Self-Regulatory Organizations; Municipal Securities Rulemaking Board; Notice of Filing of...

Science.gov (United States)

2011-06-03

...\\ See letter from F. John White, Chief Executive Officer, Public Financial Management, Inc., dated... Financial Strategies, dated March 21, 2011 (``Nathan Howard Letter''); letter from Mike Nicholas, Chief... preserve the general confusion between the role of a financial advisor and the role of an underwriter and...

Šveitsi arhitektuur kui kunstiteos

Index Scriptorium Estoniae

2004-01-01

Rotermanni soolalao arhitektuurimuuseumi näitusesaalides Jacques Lucani kureeritud šveitsi kaasaegse arhitektuuri näitus "A Matter of Art", mis esitleb šveitsi tipparhitekte (Peter Zumthor, Anette Gigon, Mike Guyer, arhitektuuribürood Herzog & de Meuron, Diener & Diener jt.) ja aastail 1997-2001 ehitatud hooneid. Filmiprogramm

Environmental Assessment for Destin 4th of July Fireworks and Beach Cleanup

Science.gov (United States)

2008-06-01

have the most restricted breeding range. The major nesting beach for the species is located near Rancho Nuevo on the northeastern coast of Mexico...proposed actions, contact: Mike Spaits, 96th Civil Engineer Group Environmental Public Affairs, 501 De Leon Street, Suite 101, Eglin AFB, Florida

Sadhana | Indian Academy of Sciences

Indian Academy of Sciences (India)

Permanent link: https://www.ias.ac.in/article/fulltext/sadh/040/08/2411-2428. Keywords. Conceptual hydrological NAM model; calibration; sensitivity analysis; validation; Tapi basin; Purna catchment. Abstract. In present study, a lumped conceptual hydrological model, NAM (MIKE11), is calibrated while optimizing the runoff ...

The effect of em>Hydrobia ulvaeem> and microphytobenthos on cohesive sediment dynamics on an intertidal mudflat described by means of numerical modelling

DEFF Research Database (Denmark)

Lumborg, Ulrik; Andersen, Thorbjørn Joest; Pejrup, Morten

2006-01-01

been used as input to the 2D hydrodynamic numerical model MIKE 21 MT. The model was used to investigate the effect that differences in the benthic communities may have on the net deposition. The model included computation of hydrodynamics, wave fields and cohesive sediment dynamics. Based...

Annual Tropical Cyclone Report 2011

Science.gov (United States)

2012-05-24

Ann Schrader, Mr. Mike Frost, and Mr. Chris Sisko for their outstanding support and continued development of the ATCF system. 5 JTWC Personnel...AG2 Ethan Wright AGAA Kristin Terrell AGAA Tyler Terrell AGAN Vaughan Dill 6 Table of Contents CHAPTER 1 WESTERN NORTH PACIFIC OCEAN

Harry Potteri film tänasest Eesti fännide ees - vanusepiiranguta! / Lauri Birkan

Index Scriptorium Estoniae

Birkan, Lauri

2005-01-01

Järjekorras neljas Potteri ekraniseering "Harry Potter ja tulepeeker" ("Harry Potter and the Goblet of Fire") jõudis Eestisse. Režissöör Mike Newell : Suurbritannia-USA 2005. Lisatud lühike sisukokkuvõte "Harryl mure mure otsa" ning filmi kinoedu tutvustav "Edetabelite tipus"

78 FR 59223 - Airworthiness Directives; Diamond Aircraft Industries GmbH Airplanes

Science.gov (United States)

2013-09-26

... safety washer and the nose landing gear attachment lever causes the rod end to bend at each gear... information at the FAA, Small Airplane Directorate, 901 Locust, Kansas City, Missouri 64106. For information...: Mike Kiesov, Aerospace Engineer, FAA, Small Airplane Directorate, 901 Locust, Room 301, Kansas City...

Software Technology for Adaptable Reliable Systems (STARS) Workshop Held at the Naval Research Laboratory, Washington, DC on April 9-12 1985

Science.gov (United States)

1985-01-01

Barrie Baston , MITRE Mike Glasgow, IBM Geoff Mendal, Lockheed LL :8: i::6:: 856 "_--’... ISSUES 1. Define forms and provide rationale for selection: a...George Mendal, Lockheed Missiles and Space Alan Blair, General Dynamics Steve Huseth, Honeywell Miguel Carrio, Teledyne Brown Engineering Barrie Baston

Mixing Over Rough Topography

Science.gov (United States)

2017-10-25

www.apl.washington.edu/ people /profile.php?last_name=Gregg&first_name=Mike LONG-TERM GOALS To understand quantify diapycnal mixing in the ocean...ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) Office of Naval Research ONR 875 North Randolph Street Arlington, VA 22203-1995 11

Joint Armaments Conference, Exhibition and Firing Demonstration

Science.gov (United States)

2010-05-20

water Initially Prepared in 1910 by Roth and Hoffman Has found use as primer sensitizer as it is “non-toxic” (mercury fulminate ) and non-corrosive...isolation/structure elucidation and synthesis of natural products with antineoplastic properties. Mike has a Ph.D. in Synthetic Organic Chemistry

100+ ideas for teaching mathematics

CERN Document Server

Ollerton, Mike

2007-01-01

All Mike's ideas have been tried and tested at the chalkface. This second edition will be at least 20% bigger and will contain ideas which range from simple addition to using and applying trigonometry, from naming 2D shapes to exploring the intrigues of 3D solids.

Contrasts between American and Afghan Warriors, a Comparison between two Martial Cultures

Science.gov (United States)

2010-06-11

nation. I am deeply indebted to MAJ Mike Kuhn for volunteering as my unofficial research coordinator, lending me his books , and providing me the most...Kabul from her roof, as well as secondhand stories from officers of her immediate acquaintance. Lady Sale records the siege and subsequent...

Pop / Tõnu Kaalep

Index Scriptorium Estoniae

Kaalep, Tõnu, 1966-2018

2003-01-01

Heliplaatidest: Rinneradio "Lumix", Lisa Marie Presley "To Whom It May Concern", Erinevad esitajad "The Matrix Reloaded: The Album", Killer Mike "Monster", The Concretes "The Concretes", Deftones "Deftones", Godsmack "Faceless", Wimme "Barru", Alkaline Trio "Good Mourning", Set Fire To Flame "Telegraphs in Negative / Mouths trapped in Static"

Teacher's Action Plan for "Shuttle External Tank and Solid Rocket Booster Math"

Science.gov (United States)

Prince, Mike

2007-01-01

My name is Mike Prince and I was one of eleven Brevard County teachers selected by United Space Alliance, LLC (USA), to work at the Kennedy Space Center (KSQ along side USA & NASA engineers during the Summer of 2007. Attached is a summary of my experience.

Representing the Ghetto Playground: From "Be Like Mike" to "Hoop Dreams."

Science.gov (United States)

Chown, Jeffrey

This paper traces representational strategies employed by "Hoop Dreams," the documentary for which two black teenagers and their families consented to have three white film makers follow them around in their day-to-day life for five years. Storytelling techniques, choice of narrator, and on- vs. off-screen action all reflect film maker…

The Trailwatcher: A Collection of Colonel Mike Malone’s Writings

Science.gov (United States)

1982-06-21

washtub-sized turtle is boat Stand reaches but more brute force. the six eases its noose ’s head and neck. As the noose , the , short on... nebulous term for who would that?" I saw a functions: was constrain them to work on what to be down here won’t like range cards that any told me...the process never ceases. me on now our factor: mot ion. What motivates a of books that have been written on motivation handle on this nebulous term