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Sample records for michael type addition

  1. Radiation curable Michael addition compounds

    International Nuclear Information System (INIS)

    Gruber, G.W.; Friedlander, C.B.; McDonald, W.H.; Dowbenko, R.

    1979-01-01

    Radiation polymerizable acrylyloxy-containing reaction products are provided from Michael addition reaction of an amide containing at least two acrylate groups with a primary or secondary amine. The resulting amine adducts of the amide, which contain at least one acrylate group per molecule, possesses high cure rates in air and are useful in compositions for forming coatings. (author)

  2. Spectroscopic Evidence for Covalent Binding of Sulfadiazine to Natural Soils via 1,4-nucleophilic addition (Michael Type Addition) studied by Spin Labeling ESR

    Science.gov (United States)

    Aleksandrova, Olga

    2015-04-01

    with different polarity. As shown by the spin labeling ESR experiment, molecules modeling SDZ were promptly bound to non-hydrolysable network of soil organic matter only via the aromatic amines that was accompanied by a prompt enlargement of humic particles binding aromatic amines, whereas binding of decomposition products of SDZ to humic acids of soil via the aliphatic amines was not observable. The ESR spectra obviously showed a single-phase process of covalent binding of the aromatic amines. Repeated washouts of labeled soil samples using distil water and ultrafiltration through the membrane of 5000 MWCO PES confirmed irreversible binding of the aromatic amines, and showed that via the aliphatic amines, binding of SDZ or decomposition products of SDZ to soil might also occur but reversibly and only to small soil molecules, which don't enter into the composition of non-hydrolysable part of soil organic matter. SL ESR experiments of different soils at the presence of Laccase highlighted that covalent binding of the aromatic amines to humic particles occurred in the specific hydrophobic areas of soil found as depleted in oxygen. All measured data evidenced that first, SDZ might be decomposed that allowed for measuring the same change of a paramagnetic signal of soil organic matter influenced by both aromatic and aliphatic amines as in the experiment of the interaction of soil with SDZ. Second, a decomposition product of SDZ with the aromatic amine might be bound to non-hydrolysable parts of soil organic matter under specific anaerobic conditions only via 1,4 - nucleophilic addition, Michael-type addition. Gulkowska, A., Thalmann, B., D., Hollender, J., & Krauss, M. (2014). Chemosphere, 107, 366 - 372. Müller, T., Rosendahl, I., Focks, A., Siemens, J., Klasmeier, J., & Matthies. (2013). Environmental Pollution, 172,180 - 185. Nowak, K.M., Miltner, A., Gehre, M., Schaeffer, A., & Kaestner, M. (2011). Environmental Science & Technology 45, 999 - 1006. Weber, E.J., Spidle

  3. Double Michael Addition Reaction of Bischalcone under Ultrasound

    Institute of Scientific and Technical Information of China (English)

    LI,Ji-Tai; XU,Wen-Zhi; CHEN,Guo-Feng; LI,Tong-Shuang

    2004-01-01

    @@ The Michael addition of 1,5-diaryl-1,4-pentadien-3-ones with active methylene compounds has been the subjects of many investigations. Ultrasound has increasingly been used in organic synthesis in the last three decades. Compared with traditional methods, this method is more convenient and easily controlled. A large number of organic reactions can be carried out in higher yield, shorter reaction time or milder conditions under ultrasonic irradiation. KF/Al2O3 as a useful solid supported catalyst has received considerable attention because of their high level of chemoselectivity and environmental compatibility as well as simplicity of operation and their ready availability at low cost. Herein we report the double Michael addition of dibenzalacetone with active methlene compounds such as dimethyl malonate, diethyl malonate,methyl cyanoacetate and ethyl cyanoacetate catalyzed by KF/Al2O3 under ultrasound irradiation.

  4. Asymmetric Michael Addition Mediated by Chiral Ionic Liquids

    Science.gov (United States)

    Suzuki, Yumiko

    2018-01-01

    Chiral ionic liquids with a focus on their applications in asymmetric Michael additions and related reactions were reviewed. The examples were classified on the basis of the mode of asymmetric induction (e.g., external induction/non-covalent interaction or internal induction/covalent bond formation), the roles in reactions (as a solvent or catalyst), and their structural features (e.g., imidazolium-based chiral cations, other chiral oniums; proline derivatives). Most of the reactions with high chiral induction are Michael addition of ketones or aldehydes to chalcones or nitrostyrenes where proline-derived chiral ionic liquids catalyze the reaction through enamine/ iminium formation. Many reports demonstrate the recyclability of ionic liquid-tagged pyrrolidines. PMID:29861702

  5. Asymmetric Michael Addition Mediated by Chiral Ionic Liquids.

    Science.gov (United States)

    Suzuki, Yumiko

    2018-06-01

    Chiral ionic liquids with a focus on their applications in asymmetric Michael additions and related reactions were reviewed. The examples were classified on the basis of the mode of asymmetric induction (e.g., external induction/non-covalent interaction or internal induction/covalent bond formation), the roles in reactions (as a solvent or catalyst), and their structural features (e.g., imidazolium-based chiral cations, other chiral oniums; proline derivatives). Most of the reactions with high chiral induction are Michael addition of ketones or aldehydes to chalcones or nitrostyrenes where proline-derived chiral ionic liquids catalyze the reaction through enamine/ iminium formation. Many reports demonstrate the recyclability of ionic liquid-tagged pyrrolidines.

  6. Asymmetric organocatalytic Michael addition of Meldrum's acid to nitroalkenes: probing the mechanism of bifunctional thiourea organocatalysts

    OpenAIRE

    Kataja, Antti O.; Koskinen, Ari M.P.

    2010-01-01

    The asymmetric Michael addition of Meldrum’s acid to nitroalkenes was studied using a novel type of Cinchona alkaloid-based bifunctional thiourea organocatalyst. The functionality of the thiourea catalysts was also probed by preparing and testing thiourea-N-methylated analogues of the well-known bis-(3,5-trifluoromethyl)phenyl-substituted catalyst. Peer reviewed

  7. Arenethiolatecopper(I) complexes as homogeneous catalysts for Michael addition reactions

    NARCIS (Netherlands)

    Koten, G. van; Klaveren, M. van; Lambert, F.; Eijkelkamp, D.J.F.M.; Grove, D.M.

    1994-01-01

    Arenethiolatocopper(I) complexes are shown to be efficient homogeneous catalysts in Michael addition reactions of several Grignard reagents to acyclic enones; the addition products are formed with excellent chemoselectivity (>99%) and good enantioselectivity (76% e.e.).

  8. Hexafluorobenzene: A powerful solvent for a noncovalent stereoselective organocatalytic Michael addition reaction

    KAUST Repository

    Lattanzi, Alessandra; De Fusco, Claudia; Russo, Alessio; Poater, Albert; Cavallo, Luigi

    2012-01-01

    A dramatic enhancement of the diastereo- and enantioselectivity in the nitro-Michael addition reaction organocatalysed by a commercially available α,α-l-diaryl prolinol was disclosed when performing the reaction in unconventional hexafluorobenzene

  9. Solvent-free microwave-mediated Michael addition reactions

    Indian Academy of Sciences (India)

    Unknown

    obviously difficult to scale up. In this context ... eco-friendly features such as, (i) no solvent is required to conduct the ... water soluble, addition of reaction mixture after com- ..... Yield: 855 mg (89%; viscous liquid). 3.4 Ethyl .... Jung M E 1993 Comprehensive organic synthesis ... Leshcheva I F and Bundel Y G 1997 Mendeleev.

  10. On the Michael addition of water to C = C bonds

    NARCIS (Netherlands)

    Chen, B.

    2015-01-01

    ?-Hydroxy carbonyl compounds are an important class of compounds often found as a common structural motif in natural products. Although the molecules themselves look rather simple, their synthesis can be challenging. Water addition to conjugated C = C bonds opens up a straightforward route for the

  11. Inverting the diastereoselectivity of the mukaiyama-michael addition with graphite-based catalysts

    KAUST Repository

    Acocella, Maria Rosaria

    2014-02-07

    Here, we show that graphite-based catalysts, mainly graphite oxide (GO) and exfoliated GO, are effective recyclable catalysts for a relevant stereoselective Mukaiyama-Michael addition, outperforming currently available catalysts. Moreover, the graphite-based catalysts described here invert the diastereoselectivity relative to that observed with known catalysts, with the unprecedented large prevalence of the anti diastereoisomer. This inverted diastereoselectivity is increased when the catalyst concentration is reduced and after catalyst recycling. Density functional theory calculations suggest that the selectivity is determined by two types of supramolecular interactions operating between the catalyst and the substrates at the diastereoselectivity- determining transition state, specifically, the π-stacking of b-nitrostyrene with graphite and the van der Waals interaction between the SiMe3 group of the silyl ether and the graphite. © 2013 American Chemical Society.

  12. SYNTHESIS OF SOME PROLINE DERIVATIVES BY MEANS OF MICHAEL ADDITIONS OF GLYCINE ESTERS

    NARCIS (Netherlands)

    VANDERWERF, A; KELLOGG, RM

    1991-01-01

    Addition of the Schiff bases derived from reaction of glycine alkyl esters with benzophenoneimine to alpha,beta-unsaturated ketones, followed by hydrogenation of the addition products, leads to 5- or 3,5-substituted prolines. Hydrolysis of the Michael adducts rather than hydrogenation allows

  13. A Greener, Efficient Approach to Michael Addition of Barbituric Acid to Nitroalkene in Aqueous Diethylamine Medium

    Directory of Open Access Journals (Sweden)

    Hany J. Al-Najjar

    2014-01-01

    Full Text Available An efficient method for the synthesis of a variety of pyrimidine derivatives 3a–t by reaction of barbituric acids 1a,b as Michael donor with nitroalkenes 2a–k as Michael acceptor using an aqueous medium and diethylamine is described. This 1,4-addition strategy offers several advantages, such as using an economic and environmentally benign reaction media, high yields, versatility, and shorter reaction times. The synthesized compounds were identified by 1H-NMR, 13C-NMR, CHN, IR, and MS. The structure of compound 3a was further confirmed by single crystal X-ray structure determination.

  14. Highly Functionalized Cyclopentane Derivatives by Tandem Michael Addition/Radical Cyclization/Oxygenation Reactions

    Czech Academy of Sciences Publication Activity Database

    Holan, Martin; Pohl, Radek; Císařová, I.; Klepetářová, Blanka; Jones, P. G.; Jahn, Ullrich

    2015-01-01

    Roč. 21, č. 27 (2015), s. 9877-9888 ISSN 0947-6539 R&D Projects: GA ČR GA13-40188S Institutional support: RVO:61388963 Keywords : cyclization * domino reactions * electron transfer * Michael addition * radical reactions Subject RIV: CC - Organic Chemistry Impact factor: 5.771, year: 2015

  15. Hexafluorobenzene: A powerful solvent for a noncovalent stereoselective organocatalytic Michael addition reaction

    KAUST Repository

    Lattanzi, Alessandra

    2012-01-01

    A dramatic enhancement of the diastereo- and enantioselectivity in the nitro-Michael addition reaction organocatalysed by a commercially available α,α-l-diaryl prolinol was disclosed when performing the reaction in unconventional hexafluorobenzene as a medium. DFT calculations were performed to clarify the origin of stereoselectivity and the role of C 6F 6. © The Royal Society of Chemistry 2012.

  16. An efficient oxa-Michael addition to diethyl vinylphosphonate under mild reaction conditions

    Czech Academy of Sciences Publication Activity Database

    Baszczyňski, Ondřej; Jansa, Petr; Dračínský, Martin; Kaiser, Martin Maxmilian; Špaček, Petr; Janeba, Zlatko

    2012-01-01

    Roč. 2, č. 4 (2012), s. 1282-1284 ISSN 2046-2069 R&D Projects: GA MV VG20102015046 Institutional research plan: CEZ:AV0Z40550506 Keywords : oxa-Michael addition * secondary alcohols * diethyl vinylphosphonate Subject RIV: CC - Organic Chemistry Impact factor: 2.562, year: 2012

  17. DNA-based catalytic enantioselective intermolecular oxa-Michael addition reactions

    NARCIS (Netherlands)

    Megens, Rik P.; Roelfes, Gerard

    2012-01-01

    Using the DNA-based catalysis concept, a novel Cu(II) catalyzed enantioselective oxa-Michael addition of alcohols to enones is reported. Enantioselectivities of up to 86% were obtained. The presence of water is important for the reactivity, possibly by reverting unwanted side reactions such as

  18. Organocatalytic asymmetric michael addition of aldehydes to beta-nitroacroleine dimethyl acetal.

    Science.gov (United States)

    Reyes, Efraim; Vicario, Jose L; Badía, Dolores; Carrillo, Luisa

    2006-12-21

    [Structure: see text] The organocatalytic asymmetric Michael addition of aldehydes to beta-nitroacroleine dimethyl acetal has been studied in detail. The reaction took place with excellent yields and high stereoselectivities when a chiral beta-amino alcohol such as L-prolinol was employed as the catalyst, leaving a formation of highly functionalized enantioenriched compounds containing two differentiated formyl groups together with a nitro moiety.

  19. Organocatalytic Asymmetric Michael Addition of 4-Hydroxycoumarin to β,γ-Unsaturated α-Keto Esters

    Energy Technology Data Exchange (ETDEWEB)

    Suh, Chang Won; Han, Tae Hyun; Kim, Dae Young [Soonchunhyang Univ., Asan (Korea, Republic of)

    2013-06-15

    In conclusion, we have developed organocatalytic enantioselective conjugate addition reaction of 4-hydroxycoumarin (1) to β,γ-unsaturated α-keto esters 2 to afford biologically valuable warfarin derivatives 3. The process is efficiently catalyzed by a binaphthyl-modified thiourea organocatalyst. The coumarin core is present as a characteristic structural motif in a large number of natural products and biologically active molecules.1 Particularly, many of these naturally occurring 4-hydroxycoumarin and their synthetic analogues are important precursors for the synthesis of natural products and pharmaceuticals. Enantioselective organocatalytic conjugate addition of 4-hydroxycoumarin to α,β-unsaturated ketones is a straightforward method to access warfarin which is an effective anticoagulants. Although a number of reactions of α,β-unsaturated ketones as Michael acceptors have been reported, the corresponding β,γ-unsaturated α-keto esters have received relatively little attention as Michael acceptors. Recently, several groups have reported the asymmetric Michael addition of 4-hydroxycoumarin to β,γ-unsaturated α-keto esters catalyzed by Cu(II)-bisoxazoline, N,N'-dioxide-Ni(II) complexes, thiourea catalysts. Although several efficient methods have been achieved by these systems, an effective method for the synthesis of warfarin analogues is still a challenge.

  20. Organocatalytic Asymmetric Michael Addition of 4-Hydroxycoumarin to β,γ-Unsaturated α-Keto Esters

    International Nuclear Information System (INIS)

    Suh, Chang Won; Han, Tae Hyun; Kim, Dae Young

    2013-01-01

    In conclusion, we have developed organocatalytic enantioselective conjugate addition reaction of 4-hydroxycoumarin (1) to β,γ-unsaturated α-keto esters 2 to afford biologically valuable warfarin derivatives 3. The process is efficiently catalyzed by a binaphthyl-modified thiourea organocatalyst. The coumarin core is present as a characteristic structural motif in a large number of natural products and biologically active molecules.1 Particularly, many of these naturally occurring 4-hydroxycoumarin and their synthetic analogues are important precursors for the synthesis of natural products and pharmaceuticals. Enantioselective organocatalytic conjugate addition of 4-hydroxycoumarin to α,β-unsaturated ketones is a straightforward method to access warfarin which is an effective anticoagulants. Although a number of reactions of α,β-unsaturated ketones as Michael acceptors have been reported, the corresponding β,γ-unsaturated α-keto esters have received relatively little attention as Michael acceptors. Recently, several groups have reported the asymmetric Michael addition of 4-hydroxycoumarin to β,γ-unsaturated α-keto esters catalyzed by Cu(II)-bisoxazoline, N,N'-dioxide-Ni(II) complexes, thiourea catalysts. Although several efficient methods have been achieved by these systems, an effective method for the synthesis of warfarin analogues is still a challenge

  1. Production of Low-Freezing-Point Highly Branched Alkanes through Michael Addition.

    Science.gov (United States)

    Jing, Yaxuan; Xia, Qineng; Liu, Xiaohui; Wang, Yanqin

    2017-12-22

    A new approach for the production of low-freezing-point, high-quality fuels from lignocellulose-derived molecules was developed with Michael addition as the key step. Among the investigated catalysts, CoCl 2 ⋅6 H 2 O was found most active for the Michael addition of 2,4-pentanedione with FA (single aldol adduct of furfural and acetone, 4-(2-furanyl)-3-butene-2-one). Over CoCl 2 ⋅6 H 2 O, a high carbon yield of C 13 oxygenates (about 75 %) can be achieved under mild conditions (353 K, 20 h). After hydrodeoxygenation, low-freezing-point (hydrodeoxygenation, high density (0.8415 g mL -1 ) and low-freezing-point (<223 K) branched alkanes with 18, 23 carbons within lubricant range were also obtained over a Pd/NbOPO 4 catalyst. These highly branched alkanes can be directly used as transportation fuels or additives. This work opens a new strategy for the synthesis of highly branched alkanes with low freezing point from renewable biomass. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Correction: Synthesis of pyrrolidine-3-carboxylic acid derivatives via asymmetric Michael addition reactions of carboxylate-substituted enones.

    Science.gov (United States)

    Yin, Feng; Garifullina, Ainash; Tanaka, Fujie

    2018-04-25

    Correction for 'Synthesis of pyrrolidine-3-carboxylic acid derivatives via asymmetric Michael addition reactions of carboxylate-substituted enones' by Feng Yin et al., Org. Biomol. Chem., 2017, 15, 6089-6092.

  3. N-Heterocyclic Carbene-Catalysed Diastereoselective Vinylogous Michael Addition Reaction of gamma-Substituted deconjugated Butenolides

    KAUST Repository

    Guo, Hao; Xing, Fen; Du, Guang-Fen; Huang, Kuo-Wei; Dai, Bin; He, Lin

    2015-01-01

    An efficient N-heterocyclic carbene (NHC)-catalysed vinylogous Michael addition of deconjugated butenolides was developed. In the presence of 5 mol% of the NHC catalyst, both γ-alkyl and aryl-substituted deconjugated butenolides undergo vinylogous Michael addition with various α, β-unsaturated ketones, esters, or nitriles to afford γ,γ-disubstituted butenolides containing adjacent quaternary and tertiary carbon centers in good to excellent yields with excellent diastereoselectivities. In this process, the free carbene is assumed to act as a strong Brønsted base to promote the conjugate addition.

  4. N-Heterocyclic Carbene-Catalysed Diastereoselective Vinylogous Michael Addition Reaction of gamma-Substituted deconjugated Butenolides

    KAUST Repository

    Guo, Hao

    2015-11-16

    An efficient N-heterocyclic carbene (NHC)-catalysed vinylogous Michael addition of deconjugated butenolides was developed. In the presence of 5 mol% of the NHC catalyst, both γ-alkyl and aryl-substituted deconjugated butenolides undergo vinylogous Michael addition with various α, β-unsaturated ketones, esters, or nitriles to afford γ,γ-disubstituted butenolides containing adjacent quaternary and tertiary carbon centers in good to excellent yields with excellent diastereoselectivities. In this process, the free carbene is assumed to act as a strong Brønsted base to promote the conjugate addition.

  5. Synthesis of some pyridine and pyrimidine derivatives via Michael-Addition

    International Nuclear Information System (INIS)

    El-Baih, Fatma E.M.; Al-Rasheed, Hessa H.; Al-Hazimi, Hassan M.

    2006-01-01

    Synthesis of pyridine and pyrimidine analogues 4 and 6-9 were achieved by Michael-addition of compounds containing either active methylene groups like, malononitrile , ethyl cyanoacetate and 1-tetralone or compounds containing active hydrogen atoms like, guanidine in the presence of an oxidizing agent and thiourea to 2-arylmethylidine-1-tetralone and 2-arylmethylidine-6-methoxy-1-tetralone (2) (enones). Addition of malononitrile in piperidine at room temperature to 2-amino-3-cyno-naphtho [1, 2-malonoitrile in sodium alkoxide or sodium hydroxide to 2 gave 4. Cyclization of 3a with acetic anhydride in the presence of conc. H2sO4 gave the naphtha-pyrano[2, 3-d]pyrimidin-8-one (5). Condensation of the pyrimidine thione derivatives 9 with chloroacetic acid gave the 3-oxobenzo[h]thiazoladino[2, 3-b]quinazoline derivatives (10), which were reacted through their active methylene groups with aromatic aldehydes to give the arylidine derivatives 11. These compounds were also prepared in one step by reacting 9 with chloroacetic acid and aromatic aldehydes. Condensation of 9 with 3-bromopropanoic acid gave 4-oxo-benzo[h]1, 3-thiazino[2, 3-b]quinazoline derivatives (12). The structures of the prepared compounds were mainly confirmed on the basis of spectroscopic methods. (author)

  6. Novel Interecting Blends Based on Amino Terminited Oligoimides by Using Michael Addition Reaction-II

    Directory of Open Access Journals (Sweden)

    Rita R. Patel

    2012-01-01

    Full Text Available New amino terminated oligoimides (AOIs were prepared by the Michael addition reaction of various bismaleimide (1, namely, 1-(4-((4-((2, 5-dioxocyclopent-3 enylamino methyl cyclohexyl methyl cyclohexyl-1, 6-dihydropyridine-2, 5-dione with excess of various diamines (2a-c. These AOIs were characterized by elemental analysis, FT-IR spectral studies and number average molecular weight estimated by non-aqueous conductometric titrations. AOIs were then treated with acrylol chloride and resultant acryl terminated oligoimides (AcOIs samples were also characterized thermogravimetrically. Each of these AcOI was then combined with the N-phenyl maleimide (PM in THF solvent. The resultant suspensions were then heated in the presence of azobisisobutyronitrile (AIBN as an initiator. The AcOI and PM polymerized through double bond simultaneously and form interacting blends, which were analyzed thermogravimetrically. The glass fiber reinforced composites were fabricated by using the suspensions of the AcOI and PM. The composites of Interacting blends were analyzed for their mechanical, chemical and electrical properties.

  7. Solvent-free, catalyst-free aza-Michael addition of cyclohexylamine to diethyl maleate: reaction mechanism and kinetics

    Czech Academy of Sciences Publication Activity Database

    Bláha, Michal; Trhlíková, Olga; Podešva, Jiří; Abbrent, Sabina; Steinhart, Miloš; Dybal, Jiří; Dušková-Smrčková, Miroslava

    2018-01-01

    Roč. 74, č. 1 (2018), s. 58-67 ISSN 0040-4020 Institutional support: RVO:61389013 Keywords : Aza-Michael addition * solvent-free * catalyst-free Subject RIV: CD - Macromolecular Chemistry OBOR OECD: Polymer science Impact factor: 2.651, year: 2016

  8. Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions

    Directory of Open Access Journals (Sweden)

    Giovanna Bosica

    2016-06-01

    Full Text Available Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs.

  9. Tandem Michael addition/radical cyclizations for the construction of highly functionalized cyclopentanes

    Czech Academy of Sciences Publication Activity Database

    Holan, Martin; Pohl, Radek; Císarová, I.; Jahn, Ullrich

    2012-01-01

    Roč. 106, - (2012), s1298-s1298 ISSN 0009-2770. [EuCheMS Chemistry Congress /4./. 26.08.2012-30.08.2012, Prague] Institutional research plan: CEZ:AV0Z40550506 Keywords : cyclization * diastereoselectivity * Michael addiction * radical reactions * domino reactions Subject RIV: CC - Organic Chemistry

  10. Theoretical study on the reaction mechanisms of Michael chirality addition between propionaldehyde and nitroalkene catalyzed by an enantioselective catalyst.

    Science.gov (United States)

    Zhou, Xinming; Li, Ling; Sun, Xuejun; Wang, Yajun; Du, Dongmei; Fu, Hui

    2018-06-01

    The asymmetric Michael addition between propionaldehyde and nitroalkene catalyzed by 8-(ethoxycarbonyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid has obtained relatively high yields and excellent enantioselectivities at room temperature. In this study, the molecular structures and optical activity of the most stable conformation I are optimized at B3LYP/6-311++ G(d,p) level. We find that levorotatory conformation I catalyzing the same Michael addition can produce laevo-product A and dextrorotatory conformation I' can obtain the dextral-product A'. These results have guiding significance for further studying on the new chemzymes and the mechanism of the obtained different chiral products. © 2018 Wiley Periodicals, Inc.

  11. Michael additions of thiocompounds to {alpha}, {beta}-unsaturated carbonyl compounds in aqueous media: stereoselectivity with unambiguous characterization by NMR

    Energy Technology Data Exchange (ETDEWEB)

    Almeida, Queli Aparecida Rodrigues de; Pereira, Maria Luiza de Oliveira; Coelho, Ricardo Bezerra; Kaiser, Carlos Roland; Jones Junior, Joel; Silva, Flavia Martins da [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Inst. de Quimica. Dept. de Quimica Organica]. E-mail: soa@iq.ufrj.br; Carvalho, Erika Martins de [Instituto de Tecnologia em Farmacos (Far-Manguinhos), Rio de Janeiro, RJ (Brazil)

    2008-07-01

    The reactions of crotonaldehyde (8) with thiophenol (2) and benzalacetone (10) with ethane-1,2- dithiol (11) yield Michael addition products. The reactions of thiophenol (2) with (R)-carvone (13) and (S)-perillaldehyde (15) lead to (2S,3R,5S)-5-isopropenyl-2-methyl-3-(phenylthio)cyclohexanone (14) and (1R,2R,4S)-4-isopropenyl-2-(phenylthio)cyclohexanecarbaldehyde (16), respectively. An unambiguous elucidation of the stereochemistry of 14 and 16 by NMR is also presented. (author)

  12. Synthesis of l-threitol-based crown ethers and their application as enantioselective phase transfer catalyst in Michael additions.

    Science.gov (United States)

    Rapi, Zsolt; Nemcsok, Tamás; Pálvölgyi, Ádám; Keglevich, György; Grün, Alajos; Bakó, Péter

    2017-06-01

    A few new l-threitol-based lariat ethers incorporating a monoaza-15-crown-5 unit were synthesized starting from diethyl l-tartrate. These macrocycles were used as phase transfer catalysts in asymmetric Michael addition reactions under mild conditions to afford the adducts in a few cases in good to excellent enantioselectivities. The addition of 2-nitropropane to trans-chalcone, and the reaction of diethyl acetamidomalonate with β-nitrostyrene resulted in the chiral Michael adducts in good enantioselectivities (90% and 95%, respectively). The substituents of chalcone had a significant impact on the yield and enantioselectivity in the reaction of diethyl acetoxymalonate. The highest enantiomeric excess (ee) values (99% ee) were measured in the case of 4-chloro- and 4-methoxychalcone. The phase transfer catalyzed cyclopropanation reaction of chalcone and benzylidene-malononitriles using diethyl bromomalonate as the nucleophile (MIRC reaction) was also developed. The corresponding chiral cyclopropane diesters were obtained in moderate to good (up to 99%) enantioselectivities in the presence of the threitol-based crown ethers. © 2017 Wiley Periodicals, Inc.

  13. Aza‐Michael addition reaction: Post‐polymerization modification and preparation of PEI/PEG‐based polyester hydrogels from enzymatically synthesized reactive polymers

    DEFF Research Database (Denmark)

    Hoffmann, Christian; Stuparu, Mihaiela C.; Daugaard, Anders Egede

    2015-01-01

    The utility of aza‐Michael addition chemistry for post‐polymerization functionalization of enzymatically prepared polyesters is established. For this, itaconate ester and oligoethylene glycol are selected as monomers. A Candida Antarctica lipase B catalyzed polycondensation reaction between the two...... monomers provides the polyesters, which carry an activated carbon‐carbon double bond in the polymer backbone. These electron deficient alkenes represent suitable aza‐Michael acceptors and can be engaged in a nucleophilic addition reaction with small molecular mono‐amines (aza‐Michael donors) to yield...... functionalized linear polyesters. Employing a poly‐amine as the aza‐Michael donor, on the other hand, results in the formation of hydrophilic polymer networks....

  14. Oxazolidine-2-thiones and thiazolidine-2-thiones as nucleophiles in intermolecular Michael additions.

    Science.gov (United States)

    Munive, Laura; Rivas, Veronica M; Ortiz, Aurelio; Olivo, Horacio F

    2012-07-06

    Conjugate addition of thiazolidinethiones and oxazolidinethiones to N-crotonylthiazolidinethiones and -oxazolidinethiones was observed in the presence of excess triethylamine in dichloromethane. The addition takes place by the nitrogen of the heterocycle with high diastereoselectivity. It was observed that the stereoselective addition occurs on the anti-s-cis conformation of the N-enoyl sulfur-containing heterocycle.

  15. A simple protocol for the michael addition of indoles with electron ...

    Indian Academy of Sciences (India)

    Administrator

    attracted much attention in organic synthesis be- cause of their biological activities. 2,3. The conjugate addition ... mations, like selective oxidation of benzyl alcohols,. 17 have been ..... The colour change was assessed visually and the highest ...

  16. Synthesis of γ-Nitro Aliphatic Methyl Esters Via Michael Additions Promoted by Microwave Irradiation

    Directory of Open Access Journals (Sweden)

    Francisco D. Díaz-Coutiño

    2009-04-01

    Full Text Available A simple and efficient protocol has been developed for the direct synthesis of γ-nitrobutyric acid methyl esters under microwave irradiation. This methodology reduces reaction times from days to minutes, compared to conventional conditions. Additionally, these conditions increased yields and provided cleaner reactions.

  17. Synthesis of γ-Nitro Aliphatic Methyl Esters Via Michael Additions Promoted by Microwave Irradiation

    OpenAIRE

    Escalante, Jaime; Díaz-Coutiño, Francisco D.

    2009-01-01

    A simple and efficient protocol has been developed for the direct synthesis of γ-nitrobutyric acid methyl esters under microwave irradiation. This methodology reduces reaction times from days to minutes, compared to conventional conditions. Additionally, these conditions increased yields and provided cleaner reactions.

  18. Michael Thonet

    Index Scriptorium Estoniae

    2005-01-01

    Saksa päritolu austria mööblidisaineri ja mööblitöösturi Michael Thonet' (1796-1871) disainiloomingust. 1859. a. Michael Thonet' loodud tool nr. 14 on endiselt tootmises ja on tuntud ka Viini toolina. 2 ill

  19. Tetrabutylammonium Bromide Media Aza-Michael Addition of 1,2,3,6-Tetrahydrophthalimide to Symmetrical Fumaric Esters and Acrylic Esters under Solvent-Free Conditions

    Directory of Open Access Journals (Sweden)

    Mohammadreza Zamanloo

    2010-10-01

    Full Text Available The aza-Michael addition of 1,2,3,6-tetrahydrophthalimide with symmetrical fumaric esters has been performed efficiently in a solvent-free system at 100 °C and using 1,4-diazabicyclo[2.2.2]octane (DABCO as a base in the presence of tetrabutylammonium bromide (TBAB. The products were obtained in good to high yields within 2.5-7.0 h. This reaction worked well on linear alkyl fumarates and was not effective with nonlinear alkyl fumarates. Although the reaction was also applicable to acrylates such as n-butyl acrylate, methacrylates and crotonates were not suitable Michael acceptors for this reaction.

  20. Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases. Part 3: Michael addition reactions and miscellaneous transformations.

    Science.gov (United States)

    Aceña, José Luis; Sorochinsky, Alexander E; Soloshonok, Vadim

    2014-09-01

    The major goal of this review is a critical discussion of the literature data on asymmetric synthesis of α-amino acids via Michael addition reactions involving Ni(II)-complexes of amino acids. The material covered is divided into two conceptually different groups dealing with applications of: (a) Ni(II)-complexes of glycine as C-nucleophiles and (b) Ni(II)-complexes of dehydroalanine as Michael acceptors. The first group is significantly larger and consequently subdivided into four chapters based on the source of stereocontrolling element. Thus, a chiral auxiliary can be used as a part of nucleophilic glycine Ni(II) complex, Michael acceptor or both, leading to the conditions of matching vs. mismatching stereochemical preferences. The particular focus of the review is made on the practical aspects of the methodology under discussion and mechanistic considerations.

  1. Catalyst-free and solvent-free Michael addition of 1,3-dicarbonyl compounds to nitroalkenes by a grinding method

    Science.gov (United States)

    Xie, Zong-Bo; Wu, Ming-Yu; He, Ting; Le, Zhang-Gao

    2012-01-01

    Summary An environmentally benign, fast and convenient protocol has been developed for the Michael addition of 1,3-dicarbonyl compounds to β-nitroalkenes in good to excellent yields by a grinding method under catalyst- and solvent-free conditions. PMID:22563352

  2. Asymmetric Domino Aza-Michael Addition/[3+2] Cycloaddition Reactions as a Versatile Approach to alpha,beta,gamma,-Triamino Acid Derivatives

    Czech Academy of Sciences Publication Activity Database

    Kapras, Vojtěch; Pohl, Radek; Císařová, I.; Jahn, Ullrich

    2014-01-01

    Roč. 16, č. 4 (2014), s. 1088-1091 ISSN 1523-7060 Institutional support: RVO:61388963 Keywords : 1,3-dipolar cycloaddition * lithium amides * aza-Michael addition * amino acids * pyrazoles Subject RIV: CC - Organic Chemistry Impact factor: 6.364, year: 2014

  3. Polyfunctional beta-Dicarbonyl Compounds by Michael Addition Reactions of Ester Enolates to alpha-Benzylidene and alpha-Alkylidene-beta-dicarbonyl Compounds

    Czech Academy of Sciences Publication Activity Database

    Holan, Martin; Pohl, Radek; Císařová, I.; Jahn, Ullrich

    -, č. 18 (2012), s. 3459-3475 ISSN 1434-193X R&D Projects: GA ČR GA203/09/1936 Institutional research plan: CEZ:AV0Z40550506 Keywords : Michael addition * diastereoselectivity * regioselectivity * enols * dicarbonyl compounds Subject RIV: CC - Organic Chemistry Impact factor: 3.344, year: 2012

  4. Metal-mediated aminocatalysis provides mild conditions: Enantioselective Michael addition mediated by primary amino catalysts and alkali-metal ions

    Directory of Open Access Journals (Sweden)

    Matthias Leven

    2013-01-01

    Full Text Available Four catalysts based on new amides of chiral 1,2-diamines and 2-sulfobenzoic acid have been developed. The alkali-metal salts of these betaine-like amides are able to form imines with enones, which are activated by Lewis acid interaction for nucleophilic attack by 4-hydroxycoumarin. The addition of 4-hydroxycoumarin to enones gives ee’s up to 83% and almost quantitative yields in many cases. This novel type of catalysis provides an effective alternative to conventional primary amino catalysis were strong acid additives are essential components.

  5. Michael Scott

    Directory of Open Access Journals (Sweden)

    Ersin Hussein

    2015-04-01

    While Michael has contributed significantly to the field of classics and ancient history by publishing extensively, he has also enjoyed great success in engaging wider audiences with the ancient world. He regularly talks in schools around the country, writes books intended for the popular market as well as articles for national and international newspapers and magazines. Michael's experience in writing and presenting a range of programmes intended for TV and radio audiences has made him a household name. He has written and presented programmes for the National Geographic, History Channel, Nova, and the BBC including Delphi: bellybutton of the ancient world (BBC4; Guilty Pleasures: luxury in the ancient and medieval words (BBC4; Jesus: rise to power (Natural Geographic; Ancient Discoveries (History Channel; Who were the Greeks? (BBC2; The Mystery of the X Tombs (BBC2/Nova; The Greatest Show on Earth (BBC4, in conjunction with the Open University. He has also presented a radio series for BBC Radio 4, Spin the Globe. Michael's most recent programme, Roman Britain from the Air, was aired on ITV in December 2014. In this interview, I talk to him about his engagement with other disciplines within the humanities, his forthcoming book project, and his experiences writing and presenting TV and radio documentaries.

  6. Multicomponent Synthesis of Isoindolinone Frameworks via RhIII -Catalysed in situ Directing Group-Assisted Tandem Oxidative Olefination/Michael Addition.

    Science.gov (United States)

    Wang, Liang; Liu, Xi; Liu, Jian-Biao; Shen, Jun; Chen, Qun; He, Ming-Yang

    2018-04-04

    A Rh III -catalysed three-component synthesis of isoindolinone frameworks via direct assembly of benzoyl chlorides, o-aminophenols and activated alkenes has been developed. The process involves in situ generation of o-aminophenol (OAP)-based bidentate directing group (DG), Rh III -catalysed tandem ortho C-H olefination and subsequent cyclization via aza-Michael addition. This protocol exhibits good chemoselectivity and functional group tolerance. Computational studies showed that the presence of hydroxyl group on the N-aryl ring could enhance the chemoselectivity of the reaction. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Nano-organocatalyst: magnetically retrievable ferrite-anchored glutathione for microwave-assisted Paal–Knorr reaction, aza-Michael addition, and pyrazole synthesis

    KAUST Repository

    Polshettiwar, Vivek; Varma, Rajender S.

    2010-01-01

    Postsynthetic Surface modification of magnetic nanoparticles by glutathione imparts desirable chemical functionality and enables the generation of catalytic sites on the surfaces of ensuing organocatalysts. In this article, we discuss the developments, unique activity, and high selectivity of nano-organocatalysts for microwave-assisted Paal-Knorr reaction, aza-Michael addition, and pyrazole synthesis. Their insoluble character Coupled with paramagnetic nature enables easy separation of these nano-catalysts from the reaction mixture using external magnet, which eliminates the requirement of catalyst filtration. Published by Elsevier Ltd.

  8. Molecular Characterization of Thiols in Fossil Fuels by Michael Addition Reaction Derivatization and Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.

    Science.gov (United States)

    Wang, Meng; Zhao, Suoqi; Liu, Xuxia; Shi, Quan

    2016-10-04

    Thiols widely occur in sediments and fossil fuels. However, the molecular composition of these compounds is unclear due to the lack of appropriate analytical methods. In this work, a characterization method for thiols in fossil fuels was developed on the basis of Michael addition reaction derivatization followed by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS). Model thiol compound studies showed that thiols were selectively reacted with phenylvinylsulfone and transformed to sulfones with greater than 98% conversions. This method was applied to a coker naphtha, light and heavy gas oils, and crude oils from various geological sources. The results showed that long alkyl chain thiols are readily present in petroleum, which have up to 30 carbon atoms. Large DBE dispersity of thiols indicates that naphthenic and aromatic thiols are also present in the petroleum. This method is capable of detecting thiol compounds in the part per million range by weight. This method allows characterization of thiols in a complex hydrocarbon matrix, which is complementary to the comprehensive analysis of sulfur compounds in fossil fuels.

  9. Stereoselective synthesis of diazaspiro[5.5]undecane derivatives via base promoted [5+1] double Michael addition of N,N-dimethylbarbituric acid to diaryliedene acetones

    Directory of Open Access Journals (Sweden)

    Mohammad Shahidul Islam

    2017-01-01

    Full Text Available The nitrogen containing spiro-heterocycle is one of the privileged synthetic motif that constitutes various naturally occurring molecules and displays a broad range of pharmaceutical and biological activities. A new methodology was developed for the synthesis of 2,4-diazaspiro[5.5]undecane-1,3,5,9-tetraones spiro-heterocyclic derivatives via cascade cyclization of [5+1] double Michael addition reaction of N,N-dimethylbarbituric acid with the derivatives of diaryldivinylketones in the presence of diethylamine at ambient temperature. The developed protocol is highly capable of furnishing diazaspiro[5.5]undecane derivatives 3a–m in excellent yields (up to 98%, from easily accessible symmetric and non-symmetric divinylketones 2a–m, containing aryl and heteroaryl substituents. The diazaspiro-heterocyclic structure was mainly elucidated by NMR and X-ray crystallographic techniques. The single-crystal X-ray studies revealed that, the cyclohexanone unit of spirocycles often prefers a chair conformation rather than twisted conformation. The intermolecular hydrogen bonding and CArH⋯π, π–π stacking interactions driving forces are mainly responsible for the crystal packing.

  10. Organocatalytic aza-Michael/retro-aza-Michael reaction: pronounced chirality amplification in aza-Michael reaction and racemization via retro-aza-Michael reaction.

    Science.gov (United States)

    Cai, Yong-Feng; Li, Li; Luo, Meng-Xian; Yang, Ke-Fang; Lai, Guo-Qiao; Jiang, Jian-Xiong; Xu, Li-Wen

    2011-05-01

    A detailed experimental investigation of an aza-Michael reaction of aniline and chalcone is presented. A series of Cinchona alkaloid-derived organocatalysts with different functional groups were prepared and used in the aza-Michael and retro-aza-Michael reaction. There was an interesting finding that a complete reversal of stereoselectivity when a benzoyl group was introduced to the cinchonine and cinchonidine. The chirality amplification vs. time proceeds in the quinine-derived organocatalyst containing silicon-based bulky group, QN-TBS, -catalyzed aza-Michael reaction under solvent-free conditions. In addition, we have demonstrated for the first time that racemization was occurred in suitable solvents under mild conditions due to retro-aza-Michael reaction of the Michael adduct of aniline with chalcone. These indicate the equilibrium of retro-aza-Michael reaction and aza-Michael reaction produce the happening of chirality amplification in aza-Michael reaction and racemization via retro-aza-Michael reaction under different conditions, which would be beneficial to the development of novel chiral catalysts for the aza-Michael reactions. Copyright © 2011 Wiley-Liss, Inc.

  11. Michael Frayn visits CERN

    CERN Multimedia

    2007-01-01

    Award-winning playwright and novelist Michael Frayn gave a guest lecture in the main auditorium at CERN on Friday 15 March about his new book The Human Touch: Our Part in the Creation of the Universe. The lecture focused on cosmology and philosophy and the limitations that language places on our ability to understand the creation of a universe in which we seem to play such a small part. In addition to his novels and plays, which include Copenhagen, a play about the 1941 meeting between German physicist Werner Heisenberg and Danish physicist Niels Bohr, Frayn has translated several works from Russian, including plays by Chekhov and Tolstoy.

  12. Michael Griffin | NREL

    Science.gov (United States)

    Griffin Photo of Michael Griffin Michael Griffin Researcher III-Chemical Engineering production of high-value products Physical and chemical material characterization under reaction conditions Physical and chemical characterization of catalytic materials Surface science Design and operation of ultra

  13. Michael E. Himmel | NREL

    Science.gov (United States)

    E. Himmel Photo of Michael E. Himmel Michael Himmel Senior Research Fellow I-Molecular Biology biochemistry, recombinant technology, enzyme engineering, new micro-organism discovery, and physicochemistry of

  14. Facile Iodine-Catalyzed Michael Addition of Indoles to α,α′-Bis(arylmethylene)cyclopentanones: An Efficient Synthesis of E-2-(3-Indolylphenylmethyl)-5-phenylmethylenecyclopentanones

    Science.gov (United States)

    Pal, Rammohan; Das Gupta, Arpita; Mallik, Asok K.

    2012-01-01

    Iodine-catalyzed reaction of indoles with α,α′-bis(arylmethylene)cyclopentanones afforded one diastereomer of the corresponding Michael adducts, namely, E-2-(3-indolylphenylmethyl)-5-phenylmethylenecyclopentanones, in a good yield. The products form a new group of indole derivatives. PMID:24052849

  15. Stereoselective synthesis of 5-alkoxycarbonyl-4 alkyl-2-anino-3-cyano-6-methyl-4H-pyranes 3 via asymmetric Michael addition to aceptors-gamma-stereogenics; Sintesis esteroselective de 5-alcoxicarbonil-4-alquil-2-amino-3-ciano-6-metil-4H-piranos via adicion Michael sobre aceptores-gama-esterogenicos

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Grau, A.; Jimenez, B.; Martin, N.; Seoane, C.; Marco, J.L. [Departamento de Quimica Organica, Facultad de Quimica, Universidad Complutense, Madrid (Spain)

    1994-12-31

    The stereoselective synthesis of 5-alkoxycarbonyl-4-alkyl-2-amino-3-cyano-6-methyl-4H-pyrans 3 via asymmetric Michael addition of malononitrile to gamma-stereogenic alpha-acetylacrylates 2 obtained by Knoevenagel reaction of acetylacetates to quiral alpha-hydroxyaldehydes 1 is described. The resulting 2-amino-4H-pyrans 3 have been obtained in moderate yield and good diastereoselectivity. 15 refs.

  16. Updating signal typing in voice: addition of type 4 signals.

    Science.gov (United States)

    Sprecher, Alicia; Olszewski, Aleksandra; Jiang, Jack J; Zhang, Yu

    2010-06-01

    The addition of a fourth type of voice to Titze's voice classification scheme is proposed. This fourth voice type is characterized by primarily stochastic noise behavior and is therefore unsuitable for both perturbation and correlation dimension analysis. Forty voice samples were classified into the proposed four types using narrowband spectrograms. Acoustic, perceptual, and correlation dimension analyses were completed for all voice samples. Perturbation measures tended to increase with voice type. Based on reliability cutoffs, the type 1 and type 2 voices were considered suitable for perturbation analysis. Measures of unreliability were higher for type 3 and 4 voices. Correlation dimension analyses increased significantly with signal type as indicated by a one-way analysis of variance. Notably, correlation dimension analysis could not quantify the type 4 voices. The proposed fourth voice type represents a subset of voices dominated by noise behavior. Current measures capable of evaluating type 4 voices provide only qualitative data (spectrograms, perceptual analysis, and an infinite correlation dimension). Type 4 voices are highly complex and the development of objective measures capable of analyzing these voices remains a topic of future investigation.

  17. Jack Michael's Motivation

    OpenAIRE

    Miguel, Caio F.

    2013-01-01

    Among many of Jack Michael's contributions to the field of behavior analysis is his behavioral account of motivation. This paper focuses on the concept of motivating operation (MO) by outlining its development from Skinner's (1938) notion of drive. Conceptually, Michael's term helped us change our focus on how to study motivation by shifting its origins from the organism to the environment. Michael's account also served to stimulate applied research and to better understand behavioral functio...

  18. Michael Faraday's Bicentenary.

    Science.gov (United States)

    Williams, L. Pearce; And Others

    1991-01-01

    Six articles discuss the work of Michael Faraday, a chemist whose work revolutionized physics and led directly to both classical field and relativity theory. The scientist as a young man, the electromagnetic experiments of Faraday, his search for the gravelectric effect, his work on optical glass, his laboratory notebooks, and his creative use of…

  19. Following Michael Faraday's Footprints

    Science.gov (United States)

    Galeano, Javier

    2011-01-01

    Last fall I had the good fortune of receiving financial support to shoot a documentary about Michael Faraday. I took the opportunity to learn more about this great experimentalist and to visit the highlights of places in his life. In this paper, I would like to share a list and description of some of the most remarkable places in London suitable…

  20. Michael Faraday, media man.

    Science.gov (United States)

    Fara, Patricia

    2006-03-01

    Michael Faraday was an enthusiastic portrait collector, and he welcomed the invention of photography not only as a possible means of recording observations accurately, but also as a method for advertising science and its practitioners. This article (which is part of the Science in the Industrial Revolution series) shows that like many eminent scientists, Faraday took advantage of the burgeoning Victorian media industry by posing in various roles.

  1. Green Michael addition of thiols to electron deficient alkenes using KF/alumina and recyclable solvent or solvent-free conditions

    Energy Technology Data Exchange (ETDEWEB)

    Lenardao, Eder J.; Trecha, Danusia O.; Ferreira, Patricia da C.; Jacob, Raquel G.; Perin, Gelson [Universidade Federal de Pelotas (UFPEL), Pelotas, RS (Brazil). Inst. de Quimica e Geociencias. Lab. de Sintese Organica Limpa (LASOL)]. E-mail: lenardao@ufpel.edu.br

    2009-07-01

    A general, clean and easy method for the conjugated addition of thiols to citral promoted by KF/Al{sub 2}O{sub 3} under solvent-free or using glycerin as recyclable solvent at room temperature is described. It was found that the solvent-free protocol is applicable to the direct reaction of thiophenol with the essential oil of lemon grass (Cymbopogon citratus) to afford directly 3,7-dimethyl-3-(phenylthio)oct-6-enal, a potential bactericide agent. The method was extended to other electron-poor alkenes with excellent results. For the solvent-free protocol, the use of microwave irradiation facilitated the procedure and accelerates the reaction. The catalytic system and glycerin can be reused up to three times without previous treatment with comparable activity. (author)

  2. Michael Jackson's Sound Stages

    OpenAIRE

    Morten Michelsen

    2012-01-01

    In order to discuss analytically spatial aspects of recorded sound William Moylan’s concept of ‘sound stage’ is developed within a musicological framework as part of a sound paradigm which includes timbre, texture and sound stage. Two Michael Jackson songs (‘The Lady in My Life’ from 1982 and ‘Scream’ from 1995) are used to: a) demonstrate the value of such a conceptualisation, and b) demonstrate that the model has its limits, as record producers in the 1990s began ignoring the conventions of...

  3. Enantioselective aminocatalysis: Michael addition of unactivated ...

    Indian Academy of Sciences (India)

    KHIANGTE VANLALDINPUIA

    2017-09-25

    Sep 25, 2017 ... the case of acetone) were stirred at room temperature for. 30 min. Nitroolefin (1 ..... Kaprzak A and Gawronski J 2001 Review on the use of cinchona ... 2006 Functionalized chiral ionic liquids as highly effi- cient asymmetric ...

  4. Professor Michael Levitt

    Directory of Open Access Journals (Sweden)

    Gemma-Louise Davies

    2015-10-01

    Full Text Available Professor Michael Levitt (Stanford University, USA won the 2013 Nobel Prize in Chemistry for the development of multiscale models for complex chemical systems—computational tools which can calculate the course of chemical reactions. Professor Levitt was born in Pretoria, South Africa; he came to the UK on a summer vacation aged 16, where he decided to stay and study for his A‑levels. His interest in the physics of living systems drove him to study biophysics at King’s College London, before securing a PhD position at the Laboratory of Molecular Biology in Cambridge. In the interim year between his degree and beginning his PhD, Professor Levitt worked at the Weizmann Institute of Science in Israel, where he met his future wife. They married later that year and moved to Cambridge, where their three children were born. After completing his PhD, he spent time working in Israel, Cambridge, the Salk Institute and Stanford (both California. Since 1986, he has split his time between Israel and California. Outside of science, he is a keen hiker and he is well-known to have attended the eclectic ‘Burning Man’ Festival in California.[1] Professor Levitt visited the University of Warwick to speak at the Computational Molecular Science Annual Conference in March 2015. In this interview, Dr Gemma-Louise Davies, an Institute of Advanced Study Global Research Fellow, spoke to Professor Levitt about the importance of Interdisciplinarity in his field, role models in Academia, and his plans for the future. Image: Professor Michael Levitt (left with Dr Scott Habershon (right, organiser of the 2015 Computational Molecular Science Annual Conference during his visit to the University of Warwick in March 2015. [1] ‘Burning Man’ is a unique annual festival dedicated to community, art, music, self-expression and self-reliance. Tens of thousands of people flock to this temporary metropolis built in the Californian desert.

  5. Synthesis of a stationary phase based on silica modified with branched octadecyl groups by Michael addition and photoinduced thiol-yne click chemistry for the separation of basic compounds.

    Science.gov (United States)

    Huang, Guang; Ou, Junjie; Wang, Hongwei; Ji, Yongsheng; Wan, Hao; Zhang, Zhang; Peng, Xiaojun; Zou, Hanfa

    2016-04-01

    A novel silica-based stationary phase with branched octadecyl groups was prepared by the sequential employment of the Michael addition reaction and photoinduced thiol-yne click chemistry with 3-aminopropyl-functionalized silica microspheres as the initial material. The resulting stationary phase denoted as SiO2 -N(C18)4 was characterized by elemental analysis, FTIR spectroscopy and Raman spectroscopy, demonstrating the existence of branched octadecyl groups in silica microspheres. The separations of benzene homologous compounds, acid compounds and amine analogues were conducted, demonstrating mixed-mode separation mechanism on SiO2 -N(C18)4 . Baseline separation of basic drugs mixture was acquired with the mobile phase of acetonitrile/H2 O (5%, v/v). SiO2 -N(C18)4 was further applied to separate Corydalis yanhusuo Wang water extracts, and more baseline separation peaks were obtained for SiO2 -N(C18)4 than those on Atlantis dC18 column. It can be expected that this new silica-based stationary phase will exhibit great potential in the analysis of basic compounds. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Michael Levitt and Computational Biology

    Science.gov (United States)

    dropdown arrow Site Map A-Z Index Menu Synopsis Michael Levitt and Computational Biology Resources with Michael Levitt, PhD, professor of structural biology at the Stanford University School of Medicine, has function. ... Levitt's early work pioneered computational structural biology, which helped to predict

  7. Effect of increased manganese addition and mould type on the ...

    Indian Academy of Sciences (India)

    Administrator

    Effect of increased manganese addition and mould type on the slurry erosion characteristics of .... slurry erosion data in the form of bar diagrams for 5M24 and 10M24 ... being bigger in size with higher austenite retention and the attendant ...

  8. Using dehydrated cement paste as new type of cement additive

    NARCIS (Netherlands)

    Yu, R.; Shui, Z.H.; Dong, J

    2013-01-01

    This paper presents an experimental study, including evaluation and modification, on using dehydrated cement paste (DCP) as a new type of cement additive. After a series of processes, normal DCP (N-DCP) was produced as before and a modified form of DCP (M-DCP) was produced as well. The cementitious

  9. Drag reduction by natural polymeric additives in PMDS microchannel: Effect of types of additives

    Directory of Open Access Journals (Sweden)

    Ling Fiona W.M.

    2017-01-01

    Full Text Available Drag reduction technology was used in medical applications to enhance the blood flow in semiclogged blood streams which can be an alternative treatment for atherosclerosis. In this present study, natural polymeric drag reducing additives (DRA was introduced to replace synthetic polymer which has the possibility of bringing side effects to human health. Three different sources, namely okra, aloe vera and hibiscus were utilized to extract the natural polymeric additives which were then tested in custom made microchannel simulating human heart blood vessels. The performance of different types of additives was evaluated using pressure measurements. The maximum drag reduction up to 63.48% is achieved using 300 ppm of hibiscus mucilage at operating pressure of 50 mbar. In this present work, hibiscus showed the best drag reduction performance, giving the highest %FI in most of the cases. This experimental results proved that these natural polymeric additives could be utilized as DRA in enhancing the blood flow in semiclogged blood streams.

  10. Development of new addition-type composite resins

    Science.gov (United States)

    Kray, R. J.

    1981-01-01

    The most promising of a number of new addition type polyimides and polyaromatic melamine (NCNS) resins for use in high performance composite materials. Three different cure temperature ranges were of interest: 530-560 K (500-550 F), 475-530 K (400-500 F), and 450 K (350 F). Examined were a wide variety of polyimide precursors terminated with 5 norbornene groups and addition polymerized at 560 K similar to PMR-15 and LARC-160 polyimides. In addition, a number of lower curing cinnamal end capped polyimides and a bismaleimide were investigated but were not found promising. A group of NCNS resins were investigated and some were found to be superior to current epoxy resins in moisture resistance, oxidative aging and flame and smoke properties.

  11. En bog om Michael Strunge

    DEFF Research Database (Denmark)

    Mai, Anne-Marie

    Antologi med bidrag om Michael Strunges forfatterskab. Bidrag af Anne-Marie Mai, Jørgen Aabenhus, Marianne Stidsen, Moritz Schramm, Tue Andersen Nexø, Lars Bukdahl, Jon Helt Haarder, Rune Kühl er optaget efter fagfællesbedømmelse. Antologien er redigeret af Anne-Marie Mai og Jørgen Aabenhus....

  12. Michael Beitz: Objects of Communication

    Science.gov (United States)

    Hoefferle, Mary

    2014-01-01

    For this Instructional Resource, the author interviewed contemporary sculptor Michael Beitz, who uses art to explore the role of designed objects in human communication and emotional experience. This column was written in response to calls for using Enduring Understandings/Big Ideas (National Coalition for Core Arts Standards, 2013; Stewart &…

  13. Michael J. Fox: Spurring Research on Parkinson's

    Science.gov (United States)

    ... turn JavaScript on. Feature: Parkinson's Disease Michael J. Fox: Spurring Research on Parkinson's Past Issues / Winter 2014 Table of Contents Michael J. Fox and his wife, actress Tracy Pollan, founded the ...

  14. Michael Faraday vs. the Spiritualists

    Science.gov (United States)

    Hirshfeld, Alan

    2006-12-01

    In the 1850s, renowned physicist Michael Faraday launched a public campaign against pseudoscience and spiritualism, which were rampant in England at the time. Faraday objected especially to claims that electrical or magnetic forces were responsible for paranormal phenomena, such as table-spinning and communication with the dead. Using scientific methods, Faraday unmasked the deceptions of spiritualists, clairvoyants and mediums and also laid bare the credulity of a public ill-educated in science. Despite his efforts, Victorian society's fascination with the paranormal swelled. Faraday's debacle anticipates current controversies about public science education and the interface between science and religion. This episode is one of many described in the new biography, The Electric Life of Michael Faraday (Walker & Co.), which chronicles Faraday's discoveries and his unlikely rise from poverty to the pinnacle of the English science establishment.

  15. Michael Niegl (1985-2009)

    CERN Multimedia

    2009-01-01

    Our friend and colleague Michael Niegl died in a tragic accident in the first hours of the new year. Michael was a Master’s student in Microsystems Engineering at the University of Applied Sciences Wiener Neustadt. He was responsible for the development of the ATLAS Beam Conditions Monitor (BCM) ROD FPGA firmware, which acquires the data from the BCM detector modules and provides online monitoring of the LHC beams within the ATLAS experiment. He spent several months at CERN to carry out beam tests on the BCM detectors and received his Bachelor of Science with first class honours for his thesis: Concept and Implementation of an FPGA-based Data Recorder and Processor for the ATLAS Beam Conditions Monitor. Michael spent six months at CERN last year to finish the development and commissioning of the ROD firmware for the first beam. He worked the entire night of 10 September to fine tune the system for the first beam. It was a joy to ...

  16. Michael De Sousa (1989 - 2012)

    CERN Multimedia

    2012-01-01

    We are deeply saddened to announce the death of Mr Michael De Sousa on 13 May 2012. Mr De Sousa, who was born on 02.09.1989, was working as an apprentice in the TE Department and had been at CERN since 24.08.2009. The Director-General has sent a message of condolence to his family on behalf of the CERN personnel. Social Affairs Human Resources Department     It is with great emotion and deep sadness that we learn of the tragic loss of our colleague and friend Michael De Sousa. Michael was a hard working colleague, cordial and considerate. Within a few months, he marked his presence by the implementation of the instrumentation benches for gas permeation measurement in polymers, and the calibration of high technology gas analyzers, necessary for vacuum technology. His last contribution will enable us to measure pressures in the extreme high vacuum range for the ELENA project.  With the continuation of this activity, his memory will remain. His accomplishments will remain...

  17. A facile and efficient method of enzyme immobilization on silica particles via Michael acceptor film coatings: immobilized catalase in a plug flow reactor.

    Science.gov (United States)

    Bayramoglu, Gulay; Arica, M Yakup; Genc, Aysenur; Ozalp, V Cengiz; Ince, Ahmet; Bicak, Niyazi

    2016-06-01

    A novel method was developed for facile immobilization of enzymes on silica surfaces. Herein, we describe a single-step strategy for generating of reactive double bonds capable of Michael addition on the surfaces of silica particles. This method was based on reactive thin film generation on the surfaces by heating of impregnated self-curable polymer, alpha-morpholine substituted poly(vinyl methyl ketone) p(VMK). The generated double bonds were demonstrated to be an efficient way for rapid incorporation of enzymes via Michael addition. Catalase was used as model enzyme in order to test the effect of immobilization methodology by the reactive film surface through Michael addition reaction. Finally, a plug flow type immobilized enzyme reactor was employed to estimate decomposition rate of hydrogen peroxide. The highly stable enzyme reactor could operate continuously for 120 h at 30 °C with only a loss of about 36 % of its initial activity.

  18. Drag reduction by natural polymeric additives in PMDS microchannel: Effect of types of additives

    OpenAIRE

    Ling Fiona W.M.; Abdulbari Hayder A.

    2017-01-01

    Drag reduction technology was used in medical applications to enhance the blood flow in semiclogged blood streams which can be an alternative treatment for atherosclerosis. In this present study, natural polymeric drag reducing additives (DRA) was introduced to replace synthetic polymer which has the possibility of bringing side effects to human health. Three different sources, namely okra, aloe vera and hibiscus were utilized to extract the natural polymeric additives which were then tested ...

  19. Michael Jackson antes del caos

    OpenAIRE

    Juan Luciano Nieves

    2015-01-01

    Michael Jackson es un buen ejemplo de cómo utilizar las relaciones públicas para realizar o manipular la imagen de un producto a través de los medios de comunicación. Este ensayo pretende analizar los eventos que tuvieron lugar antes de que el cantante fuera acusado de abuso sexual contra un menor. Dichos eventos formaron parte de un plan muy bien delineado para disminuir los efectos de la inminente crisis que se acercaba. Este trabajo combina la crítica retórica de temas de fantasía con teor...

  20. Video interview with Michael Dell

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    Michael Dell, founder and presently Chairman of the Board of Directors and Chief Executive Office of the DELL computer company visited CERN on Tuesday 26th January 2010. The Bulletin and the Video productions team had the opportunity to meet him. The video interview is transcribed for your convenience.   Michael S. Dell with CERN Director-General Rolf Heuer. What motivated you to come and visit CERN? I obviously heard about the great science and research has going on here, and DELL is very pleased to be a partner and providing a lot of the computers to analyse the data and I really wanted to see for myself in person, some of the great science that is going on here. What is your view on fundamental research in IT, and in general? I think if you look at the field of science in the last hundred years, we have been able to solve a lot of problems, but there are still lots of unsolved problems and unsolved mysteries. And it is only through basic fundamental research that we will address these probl...

  1. SuchThatCast Episode 6: Michael Boylan

    NARCIS (Netherlands)

    Soraker, Johnny

    2012-01-01

    Michael Boylan is the John J. McDonnell jr chair in Ethics, and professor and chair of the philosophy department at Marymount University in Arlington, Virginia. In addition to being a poet and novelist, he has written more than 100 published articles and 25 books primarily in ethics, social and

  2. Aza-Michael Reaction for an Undergraduate Organic Chemistry Laboratory

    Science.gov (United States)

    Nigam, Manisha; Rush, Brittney; Patel, Jay; Castillo, Raul; Dhar, Preeti

    2016-01-01

    A green, aza-Michael reaction is described that can be used to teach undergraduate students conjugate addition of nitrogen nucleophile to an a,ß-unsaturated ester. Students analyze spectral data of the product obtained from the assigned reaction to determine product structure and propose the mechanism of its formation. The experiment requires…

  3. Michael Jackson antes del caos

    Directory of Open Access Journals (Sweden)

    Juan Luciano Nieves

    2015-01-01

    Full Text Available Michael Jackson es un buen ejemplo de cómo utilizar las relaciones públicas para realizar o manipular la imagen de un producto a través de los medios de comunicación. Este ensayo pretende analizar los eventos que tuvieron lugar antes de que el cantante fuera acusado de abuso sexual contra un menor. Dichos eventos formaron parte de un plan muy bien delineado para disminuir los efectos de la inminente crisis que se acercaba. Este trabajo combina la crítica retórica de temas de fantasía con teoría de comunicación.

  4. Jack Michael's Motivation

    Science.gov (United States)

    Miguel, Caio F.

    2013-01-01

    Among many of Jack Michael's contributions to the field of behavior analysis is his behavioral account of motivation. This paper focuses on the concept of "motivating operation" (MO) by outlining its development from Skinner's (1938) notion of "drive." Conceptually, Michael's term helped us change our focus on…

  5. 49 CFR 173.466 - Additional tests for Type A packagings designed for liquids and gases.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Additional tests for Type A packagings designed...) Materials § 173.466 Additional tests for Type A packagings designed for liquids and gases. (a) In addition to the tests prescribed in § 173.465, Type A packagings designed for liquids and gases must be...

  6. The extracellular matrix of Gadus morhua muscle contains types III, V, VI and IV collagens in addition to type I

    DEFF Research Database (Denmark)

    Brüggemann, Dagmar Adeline; Lawson, M.A.

    2005-01-01

    Confocal microscopy and immuno‐histochemistry were used to examine collagens in the extracellular matrix of cod Gadus morhua swimming muscle. In addition to the well known presence of type I fibrous collagen, types III and VI were also found in the myocommata and the endomysium. The beaded collagen......, type VI, was found in the endomysium and the network forming collagen, type IV, was found in the basement membrane. This is the first report of type V collagen in cod muscle and of types II, IV and VI in the muscle of a teleost....

  7. 78 FR 6851 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Science.gov (United States)

    2013-01-31

    ... (Patient Satisfaction Survey Michael E. DeBakey Home Care Program) Activity: Comment Request AGENCY... Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form 10-0476. OMB Control Number: 2900-0775. Type... home care program staff. An agency may not conduct or sponsor, and a person is not required to respond...

  8. A click chemistry approach to glycomimetics: Michael addition of 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranose to 4-deoxy-1,2-O-isopropylidene-L-glycero-pent-4-enopyranos-3-ulose--a convenient route to novel 4-deoxy-(1-->5)-5-C-thiodisaccharides.

    Science.gov (United States)

    Witczak, Zbigniew J; Lorchak, David; Nguyen, Nguyen

    2007-09-03

    The base catalyzed conjugate Michael addition of the 1-thiosugar, 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranose, 1, to a new highly reactive enone 4-deoxy-1,2-O-isopropylidene-L-glycero-pent-4-enopyranos-3-ulose, 2, proceeds steroselectively with formation of adduct 3 in 94% yield. Convenient stereoselective reduction of the C-3 keto function of 3 with L-Selectride followed by in situ acetylation produces thiodisaccharide 4 in good 82% yield. Cleavage of the 1,2-O-isopropylidene protecting group with p-toluenesulfonic acid in methanol, followed by de-O-acetylation, produced an inseparable anomeric mixture of methyl 4-deoxy-5-C-(beta-D-glucopyranosyl)-thio-alpha/beta-L-ribo-pyranoside 5 in 72% overall yield. This approach constitutes a new general two-step click chemistry route to the previously unknown class of 4-deoxy-(1-->5)-5-C-thiodisaccharides as stable and biologically important glycomimetics.

  9. Michael Wood’s Yangzhou Dream

    Institute of Scientific and Technical Information of China (English)

    Yuan; Dan

    2014-01-01

    <正>Mr.Michael Wood is a wellknown British historian and documentary maker who has produced more than a hundred documentaries on various national histories and cultures exemplified by The Story of India.They enjoy wide popularity in more than 150 countries.I met him in February when he took his fi lm crew to Yangzhou to shoot The Story of China documentary for the British Broadcasting Corporation(BBC).It was a snowy day,cold and wet,but Michael said happily that the

  10. Michael Tomasello: Award for Distinguished Scientific Contributions.

    Science.gov (United States)

    2015-11-01

    The APA Awards for Distinguished Scientific Contributions are presented to persons who, in the opinion of the Committee on Scientific Awards, have made distinguished theoretical or empirical contributions to basic research in psychology. One of the 2015 award winners is Michael Tomasello, who received this award for "outstanding empirical and theoretical contributions to understanding what makes the human mind unique. Michael Tomasello's pioneering research on the origins of social cognition has led to revolutionary insights in both developmental psychology and primate cognition." Tomasello's award citation, biography, and a selected bibliography are presented here. (c) 2015 APA, all rights reserved).

  11. Chiral Aminophosphines as Catalysts for Enantioselective Double-Michael Indoline Syntheses

    Directory of Open Access Journals (Sweden)

    Ohyun Kwon

    2012-05-01

    Full Text Available The bisphosphine-catalyzed double-Michael addition of dinucleophiles to electron-deficient acetylenes is an efficient process for the synthesis of many nitrogen-containing heterocycles. Because the resulting heterocycles contain at least one stereogenic center, this double-Michael reaction would be even more useful if an asymmetric variant of the reaction were to be developed. Aminophosphines can also facilitate the double-Michael reaction and chiral amines are more readily available in Nature and synthetically; therefore, in this study we prepared several new chiral aminophosphines. When employed in the asymmetric double-Michael reaction between ortho-tosylamidophenyl malonate and 3-butyn-2-one, the chiral aminophosphines produced indolines in excellent yields with moderate asymmetric induction.

  12. Michael Heyrovsky, in memoriam (1932-2017)

    Czech Academy of Sciences Publication Activity Database

    Barek, J.; Černý, Slavoj; Herman, Zdeněk; Jindra, Jiří; Paleček, Emil

    2017-01-01

    Roč. 29, č. 8 (2017), s. 2001-2002 ISSN 1040-0397 Institutional support: RVO:68378114 ; RVO:61388955 ; RVO:68081707 Keywords : Michael Heyrovský Subject RIV: AB - History OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings) Impact factor: 2.851, year: 2016

  13. Reframing Michael Scott: Exploring Inappropriate Workplace Communication

    Science.gov (United States)

    Schaefer, Zachary A.

    2010-01-01

    Individuals who work in professional settings interact with others who may exhibit a variety of cultural beliefs and decision-making approaches. Page (2007) argues that cognitive diversity (i.e., how people approach and attempt to solve problems) is a vital asset in effective organizations. Michael Scott, who portrays the inept main character on…

  14. Michael Hauskeller: Sex and the Posthuman Condition

    NARCIS (Netherlands)

    Miller, Lantz Eugene

    2016-01-01

    This new book from Michael Hauskeller explores the currently marketed or projected sex/love products that exhibit some trait of so-called “posthumanistic” theory or design. These products are so designated because of their intention to fuse high technologies, including robotics and computing, with

  15. Aza-Michael reaction: achievements and prospects

    International Nuclear Information System (INIS)

    Rulev, Alexander Yu

    2011-01-01

    Data published in the last 10 years on the use of the aza-Michael reaction in organic synthesis are described systematically. The attention is focused on environmentally friendly processes following green chemistry principles and on methods for the synthesis of compounds that are difficult to access by other routes.

  16. Michael Haneke film Euroopa parim / M. T.

    Index Scriptorium Estoniae

    M. T.

    2005-01-01

    IX PÖFFil linastuv Michael Haneke film "Varjatud" ("Cache") võitis laupäeval mitu Euroopa Filmiakadeemia auhinda, selhulgas parima filmi, parima lavastaja, parima meesnäitleja (Daniel Auteuil) ja FIPRESCI auhinna. Parim naisnäitleja - Julia Jentsch ("Sophie Scholli viimased päevad"), operaator - Franz Lustig ("Don't Come Knocking"), stsenaarium - Hany Abu-Assad, Bero Beyer ("Kohe paradiisi")

  17. Synthesis and characterization of an additive type super plasticizers obtained from plastics cups of polystyrene

    International Nuclear Information System (INIS)

    Araujo, Carolina G.L.; Freire, Carolina B.; Tello, Cledola C. de O.

    2013-01-01

    This paper aims to describe the synthesis of an additive type superplasticizer from alternative material - plastic cups used of polystyrene - and characterize it physically and chemically in order to verify their efficiency and compare it with a commercial use superplasticizer. Following the search, the synthesized superplasticizer is used in mortars to assess their efficiency

  18. THE GALACTIC O-STAR SPECTROSCOPIC SURVEY (GOSSS). III. 142 ADDITIONAL O-TYPE SYSTEMS

    International Nuclear Information System (INIS)

    Apellániz, J. Maíz; Sota, A.; Alfaro, E. J.; Arias, J. I.; Barbá, R. H.; Walborn, N. R.; Simón-Díaz, S.; Herrero, A.; Negueruela, I.; Marco, A.; Leão, J. R. S.; Gamen, R. C.

    2016-01-01

    This is the third installment of the Galactic O-Star Spectroscopic Survey (GOSSS), a massive spectroscopic survey of Galactic O stars, based on new homogeneous, high signal-to-noise ratio, R  ∼ 2500 digital observations selected from the Galactic O-Star Catalog. In this paper, we present 142 additional stellar systems with O stars from both hemispheres, bringing the total of O-type systems published within the project to 590. Among the new objects, there are 20 new O stars. We also identify 11 new double-lined spectroscopic binaries, 6 of which are of O+O type and 5 of O+B type, and an additional new tripled-lined spectroscopic binary of O+O+B type. We also revise some of the previous GOSSS classifications, present some egregious examples of stars erroneously classified as O-type in the past, introduce the use of luminosity class IV at spectral types O4-O5.5, and adapt the classification scheme to the work of Arias et al.

  19. THE GALACTIC O-STAR SPECTROSCOPIC SURVEY (GOSSS). III. 142 ADDITIONAL O-TYPE SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Apellániz, J. Maíz [Centro de Astrobiología, CSIC-INTA, campus ESAC, camino bajo del castillo s/n, E-28 692 Madrid (Spain); Sota, A.; Alfaro, E. J. [Instituto de Astrofísica de Andalucía-CSIC, Glorieta de la Astronomía s/n, E-18 008 Granada (Spain); Arias, J. I.; Barbá, R. H. [Departamento de Física, Universidad de La Serena, Av. Cisternas 1200 Norte, La Serena (Chile); Walborn, N. R. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21 218 (United States); Simón-Díaz, S.; Herrero, A. [Instituto de Astrofísica de Canarias, E-38 200 La Laguna, Tenerife (Spain); Negueruela, I.; Marco, A. [DFISTS, EPS, Universidad de Alicante, carretera San Vicente del Raspeig s/n, E-03 690 Alicante (Spain); Leão, J. R. S. [Univ. Federal do Rio Grande do Norte—UFRN, Caixa Postal 1524, CEP 59 078-970, Natal—RN (Brazil); Gamen, R. C., E-mail: jmaiz@cab.inta-csic.es [Instituto de Astrofísica de La Plata (CONICET, UNLP), Paseo del Bosque s/n, 1900 La Plata (Argentina)

    2016-05-01

    This is the third installment of the Galactic O-Star Spectroscopic Survey (GOSSS), a massive spectroscopic survey of Galactic O stars, based on new homogeneous, high signal-to-noise ratio, R  ∼ 2500 digital observations selected from the Galactic O-Star Catalog. In this paper, we present 142 additional stellar systems with O stars from both hemispheres, bringing the total of O-type systems published within the project to 590. Among the new objects, there are 20 new O stars. We also identify 11 new double-lined spectroscopic binaries, 6 of which are of O+O type and 5 of O+B type, and an additional new tripled-lined spectroscopic binary of O+O+B type. We also revise some of the previous GOSSS classifications, present some egregious examples of stars erroneously classified as O-type in the past, introduce the use of luminosity class IV at spectral types O4-O5.5, and adapt the classification scheme to the work of Arias et al.

  20. Obituary: Michael James Ledlow, 1964-2004

    Science.gov (United States)

    Puxley, Philip John; Grashuis, Randon M.

    2004-12-01

    Michael James Ledlow died on 5 June 2004 from a large, unsuspected brain tumor. Since 2000 he had been on the scientific staff of the Gemini Observatory in La Serena, Chile, initially as a Science Fellow and then as a tenure-track astronomer. Michael was born in Bartlesville, Oklahoma on 1 October 1964 to Jerry and Sharon Ledlow. He obtained his Bachelor Degree in astrophysics at the University of Oklahoma in 1987 and attended the University of New Mexico for his graduate work, obtaining his PhD while studying Galaxy Clusters under Frazer Owen in 1994. From 1995-1997 Michael held a postdoctoral position with Jack Burns at New Mexico State University where he used various astronomical facilities including the VLA and Apache Point Observatory to study distant galaxies. From 1998-2000 Michael rejoined the Physics and Astronomy Department at the University of New Mexico where he was a visiting professor until he moved on to Gemini. At the Gemini Observatory, Mike shared in the excitement, hard work and many long days and nights associated with bringing on-line a major new astronomical facility and its instrumentation. Following its commissioning he assisted visiting observers, supported and took data for many more remote users via the queue system, and for each he showed the same care and attention to detail evident in his own research to ensure that all got the best possible data. His research concentrated on the radio and optical properties of galaxy clusters, especially rich Abell clusters such as A2125, on luminous radio galaxies, including the detection of a powerful double radio source in the "wrong sort of galaxy," the spiral system 0313-192, and on EROs (extremely red objects), dusty galaxies barely detectable at optical wavelengths. Michael thoroughly enjoyed living in Chile and enthusiastically immersed himself in the culture of his surroundings. He and his family were actively involved with the International English Spanish Association in La Serena. He had a

  1. Outcomes of 3-Year-Old Children With Hearing Loss and Different Types of Additional Disabilities

    Science.gov (United States)

    Cupples, Linda

    2014-01-01

    This research investigated the speech, language, and functional auditory outcomes of 119 3-year-old children with hearing loss and additional disabilities. Outcomes were evaluated using direct assessment and caregiver report. Multiple regressions revealed that type of additional disability and level of maternal education were significant predictors of language outcomes. Poorer outcomes were achieved in a combined group of children with autism, cerebral palsy, and/or developmental delay (DD) (Group A), compared with children with vision or speech output impairments, syndromes not entailing DD, or medical disorders (Group B). Better outcomes were associated with higher levels of maternal education. The association between better language outcomes and earlier cochlear implant switch-on approached significance. Further regression analyses were conducted separately for children with different types of additional disabilities. Level of maternal education was the only significant predictor of outcomes for Group A children, whereas degree of hearing loss was the strongest predictor for children in Group B. The findings highlight the variable impact that different types of additional disabilities can have on language development in children with hearing loss. PMID:24150488

  2. [Analysis of constituents of ester-type gum bases used as natural food additives].

    Science.gov (United States)

    Tada, Atsuko; Masuda, Aino; Sugimoto, Naoki; Yamagata, Kazuo; Yamazaki, Takeshi; Tanamoto, Kenichi

    2007-12-01

    The differences in the constituents of ten ester-type gum bases used as natural food additives in Japan (urushi wax, carnauba wax, candelilla wax, rice bran wax, shellac wax, jojoba wax, bees wax, Japan wax, montan wax, and lanolin) were investigated. Several kinds of gum bases showed characteristic TLC patterns of lipids. In addition, compositions of fatty acid and alcohol moieties of esters in the gum bases were analyzed by GC/MS after methanolysis and hydrolysis, respectively. The results indicated that the varieties of fatty acids and alcohols and their compositions were characteristic for each gum base. These results will be useful for identification and discrimination of the ester-type gum bases.

  3. Cathode solid electrolyte interface’s function originated from salt type additives in lithium ion batteries

    International Nuclear Information System (INIS)

    Kaneko, Yu; Park, Juyeon; Yokotsuji, Hokuto; Odawara, Makoto; Takase, Hironari; Ue, Makoto; Lee, Maeng-Eun

    2016-01-01

    Highlights: • Our chemical analysis determines the important functional groups of cathode’s solid electrolyte interface originated from salt type additives. • Our quantum chemical calculation reveals the redox character of the additives and their candidate chemical components of the solid electrolyte interface. • Our molecular dynamics simulation reproduces the selective lithium ion translocation and protective layer formation as the solid electrolyte interface function. - Abstract: This is the study about the cathode’s solid electrolyte interface (SEI) formation mechanism of salt type additives (STAs) and its function. To address this issue, we performed several types of chemical analysis and computer simulation techniques. In order to reveal the redox nature and oxidative decomposition dynamics, the electrolyte (EL) solution dynamics by Quantum mechanics and Molecular mechanics (QM/MM) method was applied. The estimation of SEI chemical components agrees with our chemical analyses data and other group’s reports. The molecular dynamics simulation of sub micro second sampling indicates that the SEI phase induced from STAs functions as a lithium ion selective translocation media and protective coating layer against the degradation of the solvent molecules. The results give us an insight how to design additive’s chemical structure to improve longevity of the cell in the high voltage regime.

  4. Michael Roitmann : Kalandus ei ole Eestile ilmselt prioriteetne valdkond / Michael Roitmann ; interv. Marko Saaret

    Index Scriptorium Estoniae

    Roitmann, Michael

    2003-01-01

    Ilmunud ka: Delovõje Vedomosti 3. dets. lk. 9. Euroopa Komisjoni kalandusdirektoraadi koordinaator Euroopa Liidu laienemise küsimuses Michael Roitmann juhib tähelepanu Eesti kalanduse suurematele probleemidele ning prognoosib EL-iga liitumise mõju Eesti kalandussektori arengule

  5. Glycotoxin and Autoantibodies Are Additive Environmentally Determined Predictors of Type 1 Diabetes

    Science.gov (United States)

    Beyan, Huriya; Riese, Harriette; Hawa, Mohammed I.; Beretta, Guisi; Davidson, Howard W.; Hutton, John C.; Burger, Huibert; Schlosser, Michael; Snieder, Harold; Boehm, Bernhard O.; Leslie, R. David

    2012-01-01

    In type 1 diabetes, diabetes-associated autoantibodies, including islet cell antibodies (ICAs), reflect adaptive immunity, while increased serum Nε-carboxymethyl-lysine (CML), an advanced glycation end product, is associated with proinflammation. We assessed whether serum CML and autoantibodies predicted type 1 diabetes and to what extent they were determined by genetic or environmental factors. Of 7,287 unselected schoolchildren screened, 115 were ICA+ and were tested for baseline CML and diabetes autoantibodies and followed (for median 7 years), whereas a random selection (n = 2,102) had CML tested. CML and diabetes autoantibodies were determined in a classic twin study of twin pairs discordant for type 1 diabetes (32 monozygotic, 32 dizygotic pairs). CML was determined by enzyme-linked immunosorbent assay, autoantibodies were determined by radioimmunoprecipitation, ICA was determined by indirect immunofluorescence, and HLA class II genotyping was determined by sequence-specific oligonucleotides. CML was increased in ICA+ and prediabetic schoolchildren and in diabetic and nondiabetic twins (all P < 0.001). Elevated levels of CML in ICA+ children were a persistent, independent predictor of diabetes progression, in addition to autoantibodies and HLA risk. In twins model fitting, familial environment explained 75% of CML variance, and nonshared environment explained all autoantibody variance. Serum CML, a glycotoxin, emerged as an environmentally determined diabetes risk factor, in addition to autoimmunity and HLA genetic risk, and a potential therapeutic target. PMID:22396204

  6. Highly conducting p-type nanocrystalline silicon thin films preparation without additional hydrogen dilution

    Science.gov (United States)

    Patra, Chandralina; Das, Debajyoti

    2018-04-01

    Boron doped nanocrystalline silicon thin film has been successfully prepared at a low substrate temperature (250 °C) in planar inductively coupled RF (13.56 MHz) plasma CVD, without any additional hydrogen dilution. The effect of B2H6 flow rate on structural and electrical properties of the films has been studied. The p-type nc-Si:H films prepared at 5 ≤ B2H6 (sccm) ≤ 20 retains considerable amount of nanocrystallites (˜80 %) with high conductivity ˜101 S cm-1 and dominant crystallographic orientation which has been correlated with the associated increased ultra- nanocrystalline component in the network. Such properties together make the material significantly effective for utilization as p-type emitter layer in heterojunction nc-Si solar cells.

  7. Textural properties of low-fat set-type yoghurt depending on mTG addition

    Directory of Open Access Journals (Sweden)

    Lívia Darnay

    2016-07-01

    Full Text Available Our aim was to determine how 0.5-2 U/g non-inactivated mTG affects the pH development and apparent viscosity during fermentation. Furthermore we wished to examine how the enzyme addition could change protein structure, gel strength and sensory characteristics by healthy low-fat set-type yoghurt product. Therefore commercial mTG enzyme preparation was added in different concentrations (0.5-2.0 U/g, in 0.5 U/g steps to 1.5 % bovine milk simultaneously with DVS starter culture. Our study revealed that enzyme dosage (0.5-2 U/g protein had no impact on pH development and apparent viscosity during fermentation when manufacturing low-fat (1.5 % set-type yoghurt. The addition of mTG contributed to 38 % more whey retention with incorporation of β-casein, and caused 44 % higher gel strength up to a level of 1 U/g protein.

  8. Performance ‘S’ Type Savonius Wind Turbine with Variation of Fin Addition on Blade

    Science.gov (United States)

    Pamungkas, S. F.; Wijayanto, D. S.; Saputro, H.; Widiastuti, I.

    2018-01-01

    Wind power has been receiving attention as the new energy resource in addressing the ecological problems of burning fossil fuels. Savonius wind rotor is a vertical axis wind turbines (VAWT) which has relatively simple structure and low operating speed. These characteristics make it suitable for areas with low average wind speed as in Indonesia. To identify the performance of Savonius rotor in generating electrical energy, this research experimentally studied the effect of fin addition for the ‘S’ shape of Savonius VAWT. The fin is added to fill the space in the blade in directing the wind flow. This rotor has two turbine blades, a rotor diameter of 1.1 m and rotor height of 1.4 m, used pulley transmission system with 1:4.2 multiplication ratio, and used a generator type PMG 200 W. The research was conducted during dry season by measuring the wind speed in the afternoon. The average wind speed in the area is 2.3 m/s with the maximum of 4.5 m/s. It was found that additional fin significantly increase the ability of Savonius rotor VAWT to generate electrical energy shown by increasing of electrical power. The highest power generated is 13.40 Watt at a wind speed of 4.5 m/s by adding 1 (one) fin in the blade. It increased by 22.71% from the rotor blade with no additional fin. However, increasing number of fins in the blade was not linearly increase the electrical power generated. The wind rotor blade with 4 additional fins is indicated has the lowest performance, generating only 10.80 Watt electrical power, accounted lower than the one generated by no fin-rotor blade. By knowing the effect of the rotor shape, the rotor dimension, the addition of fin, transmission, and generator used, it is possible to determine alternative geometry design in increasing the electrical power generated by Savonius wind turbine.

  9. Technological and nutritional aspect of different hemp types addition: Comparison of flour and wholemeal effect

    Directory of Open Access Journals (Sweden)

    Marie Hrušková

    2015-01-01

    Full Text Available Addition of non-traditional raw-materials and flours into wheat flour follows contemporary trend of manufacturing nutritionally healthier fermented bakery products. Aim of the study follows this tendency, evaluating nutritional improvement of composite flour and baking potential of prepared wheat-hemp flour composites. Hemp products addition significantly increased both protein and dietary fibre contents. Between five types of hemp flour, differences were observed according to incorporated amount (wheat flour substitution from 5% to 20%. In composites containing 20% of hemp flour and dehulled hemp wholemeal, protein content increased to 14.9% and to 15.7%, respectively (compared to 12.5% proteins in control wheat flour. Dietary fibre content change was governed unequivocally by addition level for both hemp flour and hemp wholemeal. Hemp wholemeal affected the solvent retention capacity (SRC profile of the wheat flour used in a broader extent than hemp flour done, interacting moreover with addition level applied. Significant diminishing was measured for the sucrose and the lactic acid SRC, which describe physicochemical stage of starch and proteins in prepared composites. Addition of 5% and 20% of dehulled hemp wholemeal decreased the formed SRC from 112.0% to 102.3% and to 64.1%, and the latter SRC from 182.6% to 108.0 and to 78.3%, respectively. Smaller bread volume and worse shape were evaluated as the amount of hemp flour gradually increased; wholemeal form had more or less a positive effect. Correspondingly to that, crumb firmness measured by penetration test was found approximately half for hemp flour composite bread than for the hemp wholemeal ones.

  10. Overlapping, Additive and Counterregulatory Effects of Type II and I Interferons on Myeloid Dendritic Cell Functions

    Directory of Open Access Journals (Sweden)

    Loredana Frasca

    2011-01-01

    Full Text Available Dendritic cells (DCs are central player in immunity by bridging the innate and adaptive arms of the immune system (IS. Interferons (IFNs are one of the most important factors that regulate both innate and adaptive immunity too. Thus, the understanding of how type II and I IFNs modulate the immune-regulatory properties of DCs is a central issue in immunology. In this paper, we will address this point in the light of the most recent literature, also highlighting the controversial data reported in the field. According to the wide literature available, type II as well as type I IFNs appear, at the same time, to collaborate, to induce additive effects or overlapping functions, as well as to counterregulate each one's effects on DC biology and, in general, the immune response. The knowledge of these effects has important therapeutic implications in the treatment of infectious/autoimmune diseases and cancer and indicates strategies for using IFNs as vaccine adjuvants and in DC-based immune therapeutic approaches.

  11. Michael Maier--nine newly discovered letters.

    Science.gov (United States)

    Lenke, Nils; Roudet, Nicolas; Tilton, Hereward

    2014-02-01

    The authors provide a transcription, translation, and evaluation of nine newly discovered letters from the alchemist Michael Maier (1568-1622) to Gebhardt Johann von Alvensleben (1576-1631), a noble landholder in the vicinity of Magdeburg. Stemming from the final year of his life, this correspondence casts new light on Maier's biography, detailing his efforts to secure patronage amid the financial crisis of the early Thirty Years' War. While his ill-fated quest to perfect potable gold continued to form the central focus of his patronage suits, Maier also offered his services in several arts that he had condemned in his printed works, namely astrology and "supernatural" magic. Remarks concerning his previously unknown acquaintance with Heinrich Khunrath call for a re-evaluation of Maier's negotiation of the discursive boundaries between Lutheran orthodoxy and Paracelsianism. The letters also reveal Maier's substantial contribution to a work previously ascribed solely to the English alchemist Francis Anthony.

  12. Mode I type delamination fracture toughness of YBCO coated conductor with additional Cu layer

    International Nuclear Information System (INIS)

    Miyazato, T.; Hojo, M.; Sugano, M.; Adachi, T.; Inoue, Y.; Shikimachi, K.; Hirano, N.; Nagaya, S.

    2011-01-01

    A fracture toughness test method was developed for a YBCO coated conductor with an additional Cu layer. Mode I type tests were carried out using double cantilever beam (DCB) specimens. Delamination propagated into the YBCO layer, and sometimes reached the Ag/YBCO interface. The fracture toughness for YBCO was about 10 J/m 2 . That for Ag/YBCO interface was about 100 J/m 2 . Although interlaminar fracture at a YBa 2 Cu 3 O 7-δ (YBCO)/CeO 2 interface was reported for YBCO coated conductors, this has not yet been investigated by a fracture mechanical approach. In the present study, we developed a mode I type fracture toughness test method for a YBCO coated conductor with an additional Cu layer using double cantilever beam (DCB) specimens. Fracture mechanism was investigated by microscopic observation by a scanning electron microscope (SEM), together with composition analysis by an energy dispersive X-ray spectroscope (EDS). A pre-crack introduced at the YBCO/CeO 2 interface deviated from the interface, and propagated into the YBCO layer, and sometimes reached the Ag/YBCO interface. The fracture toughness, G R , for YBCO and the Ag/YBCO interface was evaluated to be 7-10 J/m 2 and 80-120 J/m 2 , respectively. The complex stress intensity factor ratio, K 2 /K 1 , at YBCO/CeO 2 interface was evaluated to be -0.19, and this ratio controlled the formation of microcracks in the YBCO layer. The main crack propagated into the YBCO layer accompanied with the formation of microcracks.

  13. Interview with Michael Apple: The Biography of a Public Intellectual

    Science.gov (United States)

    Peters, Michael A.

    2015-01-01

    Michael W. Apple is the John Bascom Professor of Curriculum and Instruction and Educational Policy Studies in the Departments of Curriculum and Instruction (CI) and Educational Policy Studies (EPS) at the University of Wisconsin-Madison School of Education where he has taught since 1970. Michael Apple is one of the foremost educational theorists…

  14. Book Review: Invitation to Topological Robotics by Michael Farber

    DEFF Research Database (Denmark)

    Raussen, Martin

    2009-01-01

    Book Review: Invitaton to Topological Robotics by Michael Farber. Zurich Lectures in Advanced Mathematics, European Mathematical Society (2008), ISBN 978-3-03719-054-8......Book Review: Invitaton to Topological Robotics by Michael Farber. Zurich Lectures in Advanced Mathematics, European Mathematical Society (2008), ISBN 978-3-03719-054-8...

  15. Effect of soy addition on microwavable pocket-type flat doughs.

    Science.gov (United States)

    Serventi, Luca; Sachleben, Joseph; Vodovotz, Yael

    2011-01-01

    Microwavable frozen baked goods are widely used by the food industry. However, the altered heat and mass transfer patterns associated with microwave radiation result in tough and rubbery baked products due to reduced plasticization of the polymers. Ingredients with high water-holding capacity and high content of polar lipids have been shown to enhance gluten plasticization and to improve water retention. Therefore, this study explored the physicochemical changes imparted by microwave baking of pocket-type flat doughs with and without soy added at 10%, 20%, and 26% and compared these to their conventionally baked counterparts. Microwave baking resulted in a soft, rubbery, and tough wheat product with increased "freezable" water. Soy was added to the formulation as a means to improve polymer plasticization. Conventional baking of soy doughs resulted in rubbery and tough products due to changes in water state and mobility (freezable water approximately 15 compared with 7.09 of the control). However, soy reduced the cohesiveness of the microwave baked products reaching the lowest value at 20% soy addition (cohesiveness 0.33 ± 1, comparable to that of the conventionally baked control). These data suggest that reduction of water mobility induced by soy proteins and polar lipids (confirmed by thermogravimetric analysis [TGA] and ¹H nuclear magnetic resonance [¹H NMR]) possibly plasticized the starch-gluten network of microwave baked soy doughs. Thus, soy was shown to improve the texture of microwave baked pocket-type flat doughs although further formula optimization is warranted. Microwavable pocket-type flat doughs are used frequently by the food industry to enrobe meat, vegetable, and sweet items for convenient meal delivery. Microwave heating of such doughs induces the development of crustless products compared to conventionally baked products, resulting in a tough and rubbery texture. Partial substitution of wheat flour with soy, in the form of soy flour and soy

  16. 34 CFR 379.11 - What additional types of project activities may be authorized under this program?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false What additional types of project activities may be... EDUCATION PROJECTS WITH INDUSTRY What Kinds of Activities Does the Department of Education Assist Under This Program? § 379.11 What additional types of project activities may be authorized under this program? The...

  17. Failure mechanisms of additively manufactured porous biomaterials: Effects of porosity and type of unit cell.

    Science.gov (United States)

    Kadkhodapour, J; Montazerian, H; Darabi, A Ch; Anaraki, A P; Ahmadi, S M; Zadpoor, A A; Schmauder, S

    2015-10-01

    Since the advent of additive manufacturing techniques, regular porous biomaterials have emerged as promising candidates for tissue engineering scaffolds owing to their controllable pore architecture and feasibility in producing scaffolds from a variety of biomaterials. The architecture of scaffolds could be designed to achieve similar mechanical properties as in the host bone tissue, thereby avoiding issues such as stress shielding in bone replacement procedure. In this paper, the deformation and failure mechanisms of porous titanium (Ti6Al4V) biomaterials manufactured by selective laser melting from two different types of repeating unit cells, namely cubic and diamond lattice structures, with four different porosities are studied. The mechanical behavior of the above-mentioned porous biomaterials was studied using finite element models. The computational results were compared with the experimental findings from a previous study of ours. The Johnson-Cook plasticity and damage model was implemented in the finite element models to simulate the failure of the additively manufactured scaffolds under compression. The computationally predicted stress-strain curves were compared with the experimental ones. The computational models incorporating the Johnson-Cook damage model could predict the plateau stress and maximum stress at the first peak with less than 18% error. Moreover, the computationally predicted deformation modes were in good agreement with the results of scaling law analysis. A layer-by-layer failure mechanism was found for the stretch-dominated structures, i.e. structures made from the cubic unit cell, while the failure of the bending-dominated structures, i.e. structures made from the diamond unit cells, was accompanied by the shearing bands of 45°. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model.

    Science.gov (United States)

    Shao, Minglong; Yu, Lechu; Zhang, Fangfang; Lu, Xuemian; Li, Xiaokun; Cheng, Peng; Lin, Xiufei; He, Luqing; Jin, Shunzi; Tan, Yi; Yang, Hong; Zhang, Chi; Cai, Lu

    2015-07-01

    The onset of diabetic nephropathy (DN) is associated with both systemic and renal changes. Fibroblast growth factor (FGF)-21 prevents diabetic complications mainly by improving systemic metabolism. In addition, low-dose radiation (LDR) protects mice from DN directly by preventing renal oxidative stress and inflammation. In the present study, we tried to define whether the combination of FGF21 and LDR could further prevent DN by blocking its systemic and renal pathogeneses. To this end, type 2 diabetes was induced by feeding a high-fat diet for 12 wk followed by a single dose injection of streptozotocin. Diabetic mice were exposed to 50 mGy LDR every other day for 4 wk with and without 1.5 mg/kg FGF21 daily for 8 wk. The changes in systemic parameters, including blood glucose levels, lipid profiles, and insulin resistance, as well as renal pathology, were examined. Diabetic mice exhibited renal dysfunction and pathological abnormalities, all of which were prevented significantly by LDR and/or FGF21; the best effects were observed in the group that received the combination treatment. Our studies revealed that the additive renal protection conferred by the combined treatment against diabetes-induced renal fibrosis, inflammation, and oxidative damage was associated with the systemic improvement of hyperglycemia, hyperlipidemia, and insulin resistance. These results suggest that the combination treatment with LDR and FGF21 prevented DN more efficiently than did either treatment alone. The mechanism behind these protective effects could be attributed to the suppression of both systemic and renal pathways. Copyright © 2015 the American Physiological Society.

  19. Obituary: Michael John Klein, 1940-2005

    Science.gov (United States)

    Gulkis, Samuel

    2006-12-01

    Michael John Klein died on 14 May 2005 at home in South Pasadena, California. The cause of death was tongue cancer that metastasized to the lungs. He was a non-smoker. Mike was a passionate radio astronomer, a trusted astronomical observer, an educator and a family man. Mike was born on 19 January 1940 in Ames, Iowa, the son of Florence Marie (Graf) and Fred Michael Klein. His mother was a homemaker, and his father was a banker. Mike had two older sisters, Lois Jean (Klein) Flauher and Marilyn June (Klein) Griffin. In 1962, Mike married his high school sweetheart Barbara Dahlberg, who survives him along with their three children, Kristin Marie (Klein) Shields, Michael John Klein Jr., Timothy Joel Klein, and six grandchildren. Mike developed a love for astronomy early in his life, and credited an early morning, newspaper-delivery route that he had at age twelve, which took him outside well before sunrise. He told family members that as he walked along his route, he stared into the sky and wondered what everything was. He studied sky charts, located stars, and began to understand how the planets shifted their positions relative to the stars each day. Another big influence in Mike's life was his brother in-law, Jim Griffin. Jim helped Mike understand that his passion for science did not have to remain a hobby, but could and should become a career. Jim's encouragement led Mike to attend Iowa State University in Ames, where he earned a BS in electrical engineering in 1962. Mike then started graduate school in electrical engineering at Michigan State, but after one semester transferred to the University of Michigan, Ann Arbor, where he earned an MS (1966) and PhD (1968) in astronomy. His doctoral dissertation, under the direction of Professor Fred Haddock, was based on extensive observations of the planets and examined the physical and thermal properties of planetary atmospheres and surfaces. Mike was awarded a Resident Research Associate position at JPL by the National

  20. Race, punishment, and the Michael Vick experience.

    Science.gov (United States)

    Piquero, Alex R; Piquero, Nicole Leeper; Gertz, Marc; Baker, Thomas; Batton, Jason; Barnes, J C

    2011-01-01

    Objective. The relationship between race and crime has been contentious, focusing primarily on offending and incarceration patterns among minorities. There has been some limited work on public perceptions of criminal punishment, and findings show that while minorities believe in the role and rule of law, they simultaneously perceive the justice system as acting in a biased and/or unfair manner. Two limitations have stalled this literature. First, research has focused mainly on criminal punishments to the neglect of noncriminal punishments. Second, most studies have not examined whether race remains salient after considering other demographic variables or discrimination and legitimacy attitudes.Methods. Using data from 400 adults, we examine how race affects perceptions of criminal punishment and subsequent reinstatement into the National Football League in the case of Michael Vick, a star professional quarterback who pled guilty to charges of operating an illegal dog-fighting ring.Results. Findings show that whites are more likely to view Vick's punishment as too soft and that he should not be reinstated, while nonwhites had the opposite views. Race remained significant after controlling for other variables believed to be related to punishment perceptions.Conclusion. Attitudes toward both criminal punishment and NFL reinstatement vary across race such that there exists important divides in how individuals perceive the system meting out punishment and subsequently reintegrating offenders back into society. These results underscore that white and nonwhites perceive the law and its administration differently.

  1. Principles of formation of mobile dwelling of cluster type with application of additive technologies

    Directory of Open Access Journals (Sweden)

    Panfilov Alexander

    2017-01-01

    Full Text Available One of the most acute problems of modern society are issues related to the globalization of mankind caused by the next small scientific and technological revolution that is taking place and the emerging transition to a post-industrial society. Some of their characteristic features of this society are: deterritoriality, weakening of functional-spatial ties between places of residence, the application of labor and recreation rights. The peculiarity of the emerging new architecture with the arrival of the postindustrial information society is becoming completely new approaches to the formation of cities and the human dwelling itself. The article deals with the application of additive technologies in the production of mobile residential objects of high factory readiness. The article describes the concept of the formation of a mobile dwelling cluster type based on the principles of the organization of intelligent self-adapting systems (Smart Development, gives examples of author’s developments in the field of cluster housing, with a description of the fundamental principles necessary for the possibility of further development and technical implementation.

  2. A high-current rail-type gas switch with preionization by an additional corona discharge

    Energy Technology Data Exchange (ETDEWEB)

    Antipov, E. I.; Belozerov, O. S.; Krastelev, E. G., E-mail: ekrastelev@yandex.ru [National Research Nuclear University MEPhI (Moscow Engineering Physics Institute) (Russian Federation)

    2016-12-15

    The characteristics of a high-current rail-type gas switch with preionization of the gas (air) in a spark gap by an additional corona discharge are investigated. The experiments were performed in a voltage range of 10–45 kV using a two-electrode switch consisting of two cylindrical electrodes with a diameter of 22 mm and a length of 100 mm and a set of laterally located corona-discharge needles. The requirements for the position and size of the needles are defined for which a corona discharge is ignited before a breakdown of the main gap and does not change to a sparking form, and the entire length of the rail electrodes is efficiently used. The fulfillment of these requirements ensures stable operation of the switch with a small variation of the pulse breakdown voltage, which is not more than 1% for a fixed voltage-pulse rise time in the range from 150 ns to 3.5 μs. A short delay time of the switch breakdown makes it possible to control the two-electrode switch by an overvoltage pulse of nanosecond duration.

  3. A high-current rail-type gas switch with preionization by an additional corona discharge

    International Nuclear Information System (INIS)

    Antipov, E. I.; Belozerov, O. S.; Krastelev, E. G.

    2016-01-01

    The characteristics of a high-current rail-type gas switch with preionization of the gas (air) in a spark gap by an additional corona discharge are investigated. The experiments were performed in a voltage range of 10–45 kV using a two-electrode switch consisting of two cylindrical electrodes with a diameter of 22 mm and a length of 100 mm and a set of laterally located corona-discharge needles. The requirements for the position and size of the needles are defined for which a corona discharge is ignited before a breakdown of the main gap and does not change to a sparking form, and the entire length of the rail electrodes is efficiently used. The fulfillment of these requirements ensures stable operation of the switch with a small variation of the pulse breakdown voltage, which is not more than 1% for a fixed voltage-pulse rise time in the range from 150 ns to 3.5 μs. A short delay time of the switch breakdown makes it possible to control the two-electrode switch by an overvoltage pulse of nanosecond duration.

  4. Effect of an additional magnetic field on Hanle-type absorption resonances

    International Nuclear Information System (INIS)

    Singh Grewal, Raghwinder; Pattabiraman, M

    2014-01-01

    We computationally compare Hanle-type resonances for a F g =1→F e =0 transition of the 87 RbD 2 line for magnetic field scans parallel (longitudinal scan) and perpendicular (transverse scan) to the direction of propagation of the optical field in the presence of an additional transverse magnetic field (TMF). For a linearly polarized light, the coherent population trapping (CPT) resonances split at line centre and are identical for both longitudinal and transverse scans. When the probe beam ellipticity is varied, the effect of the TMF is found to be opposite for longitudinal and transverse scans. For a longitudinal scan, the splitting observed in the CPT resonance evolves into an enhanced absorption resonance with an increase in ellipticity. For a transverse scan, the splitting vanishes at higher ellipticities. This can be understood in terms of population redistribution in the ground state sublevels and near-neighbor ground state coherences created by the TMF. We also show that the enhanced absorption signal that splits the CPT resonance strongly depends on transit time, and the CPT resonance strength depends on the excited state dephasing rate. (paper)

  5. and chemoselective synthesis of enaminones via Michael type ...

    Indian Academy of Sciences (India)

    MONIKA PATEL

    2018-06-14

    Jun 14, 2018 ... Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, University of Delhi,. Delhi 110 007 .... The structure of compound 3a was established on the ..... L 1965 Serotonin (Amsterdam: Elsevier) p. 277. 5.

  6. The Church of St. Michael in Olomouc and its type

    Czech Academy of Sciences Publication Activity Database

    Švácha, Rostislav

    2013-01-01

    Roč. 61, č. 5 (2013), s. 398-421 ISSN 0049-5123 Institutional support: RVO:68378033 Keywords : architecture * typology * construction Subject RIV: AL - Art, Architecture, Cultural Heritage http://www.umeni-art.cz/cz/ default .aspx

  7. Michael Polanyi: Patriarch of Chemical Dynamics and Tacit Knowing.

    Science.gov (United States)

    Herschbach, Dudley R

    2017-03-20

    Connecting Science and the Humanities was the title of the symposium on Michael Polanyi that took place at the Technische Universität Berlin (Technical University of Berlin) in October 2016. This essay, which appraises the scientific and philosophical contributions of Michael Polanyi, is based on the presentation given by Dr. Herschbach on this occasion. In the photograph: Polanyi in 1931. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Principles of Chemistry (by Michael Munowitz)

    Science.gov (United States)

    Kovac, Reviewed By Jeffrey

    2000-05-01

    At a time when almost all general chemistry textbooks seem to have become commodities designed by marketing departments to offend no one, it is refreshing to find a book with a unique perspective. Michael Munowitz has written what I can only describe as a delightful chemistry book, full of conceptual insight, that uses a novel and interesting pedagogic strategy. This is a book that has much to recommend it. This is the best-written general chemistry book I have ever read. An editor with whom I have worked recently remarked that he felt his job was to help authors make their writing sing. Well, the writing in Principles of Chemistry sings with the full, rich harmonies and creative inventiveness of the King's Singers or Chanticleer. Here is the first sentence of the introduction: "Central to any understanding of the physical world is one discovery of paramount importance, a truth disarmingly simple yet profound in its implications: matter is not continuous." This is prose to be savored and celebrated. Principles of Chemistry has a distinct perspective on chemistry: the perspective of the physical chemist. The focus is on simplicity, what is common about molecules and reactions; begin with the microscopic and build bridges to the macroscopic. The author's perspective is clear from the organization of the book. After three rather broad introductory chapters, there are four chapters that develop the quantum mechanical theory of atoms and molecules, including a strong treatment of molecular orbital theory. Unlike many books, Principles of Chemistry presents the molecular orbital approach first and introduces valence bond theory later only as an approximation for dealing with more complicated molecules. The usual chapters on descriptive inorganic chemistry are absent (though there is an excellent chapter on organic and biological molecules and reactions as well as one on transition metal complexes). Instead, descriptive chemistry is integrated into the development of

  9. Guest Foreword from Michael Thomas CMG QC

    Directory of Open Access Journals (Sweden)

    Michael Thomas

    2012-04-01

    precedents and thought in a unique legal market in which ideas drawn from Islamic law, civil law and common law can intermingle and blend. It is not surprising therefore to see that this new publication will be dedicated to the subject of international law, both public and private. Its laudable aim is to promote legal discourse around the world, and to promote a wider international understanding of contemporary legal issues for the common benefit. As an open access, bilingual journal, addressing topics concerning any jurisdiction, I hope it will reach a wide audience, and fulfil its aim of promoting understanding between different cultures. I am sure that the journal will not only benefit Qatar’s legal community by advancing academic and practice-based legal discussion. I am also confident that it will stimulate thought in the global legal community at large. May I wish it every success and a long life. Michael Thomas CMG QC

  10. Fatigue performance of additively manufactured meta-biomaterials : The effects of topology and material type

    NARCIS (Netherlands)

    Ahmadi, S.M.; Hedayati, R.; Li, Y; Lietaert, K.; Tümer, N.; Fatemi, A.; Rans, C.D.; Pouran, B.; Weinans, H.H.; Zadpoor, A.A.

    2018-01-01

    Additive manufacturing (AM) techniques enable fabrication of bone-mimicking meta-biomaterials with unprecedented combinations of topological, mechanical, and mass transport properties. The mechanical performance of AM meta-biomaterials is a direct function of their topological design. It is,

  11. Enantio- and Stereoselective Construction of Atisane Scaffold via Organocatalytic Intramolecular Michael Reaction and Diels-Alder Reaction.

    Science.gov (United States)

    Sekita, Hiroko; Adachi, Kyohei; Kobayashi, Ippei; Sato, Yusuke; Nakada, Masahisa

    2017-05-05

    An enantio- and stereoselective construction of the atisane scaffold via organocatalytic intramolecular Michael reaction and Diels-Alder reaction is described. The organocatalytic intramolecular Michael reaction has been found to stereoselectively generate a trans-stereodiad comprising an all-carbon quaternary and a tertiary stereogenic centers. Use of the chiral secondary amine bearing thiourea with benzoic acid as additive is the key to obtaining the desired product with excellent ee in synthetically acceptable yield. The prepared chiral building block has been successfully converted to the compound including the atisane scaffold via the highly stereoselective intramolecular Diels-Alder reaction.

  12. Isoindolinones as Michael Donors under Phase Transfer Catalysis: Enantioselective Synthesis of Phthalimidines Containing a Tetrasubstituted Carbon Stereocenter

    Directory of Open Access Journals (Sweden)

    Francesco Scorzelli

    2015-05-01

    Full Text Available Readily available chiral ammonium salts derived from cinchona alkaloids have proven to be effective phase transfer catalysts in the asymmetric Michael reaction of 3-substituted isoindolinones. This protocol provides a convenient method for the construction of valuable asymmetric 3,3-disubstituted isoindolinones in high yields and  moderate to good enantioselectivity. Diastereoselectivity was also investigated in the construction of contiguous tertiary and quaternary stereocenters. The use of acrolein as Michael acceptor led to an interesting tricyclic derivative, a pyrroloisoindolinone analogue, via a tandem conjugated addition/cyclization reaction.

  13. Study on Type C Coal Fly ash as an Additive to Molding Sand for Steel Casting

    Science.gov (United States)

    Palaniappan, Jayanthi

    2017-04-01

    Study of physio-chemical properties studies such as granulometric analysis, moisture, X ray fluorescence etc. were performed with Type C coal—combustion fly ash to investigate their potential as a distinct option for molding sand in foundry, thereby reducing the dependency on latter. Technological properties study such as compressive strength, tensile strength, permeability and compaction of various compositions of fly ash molding sand (10, 20 and 30 % fly ash substitute to chemically bonded sand) were performed and compared with silica molding sand. Steel casting production using this fly ash molding sand was done and the casting surface finish and typical casting parameters were assessed. It was noted that a good quality steel casting could be produced using type C fly ash molding sand, which effectively replaced 20 % of traditional molding sand and binders thereby providing greater financial profits to the foundry and an effective way of fly ash utilization (waste management).

  14. Blending additions to PrFeB and NdFeB-type magnets

    International Nuclear Information System (INIS)

    Ahmad, A.; Harris, I.R.

    2001-01-01

    The RFeB system has been developed over the last fifteen years to provide permanent magnets of the highest quality for advanced applications. These magnets exhibit high saturation and good coercivity but their poor corrosion resistance and high temperature properties had led to considerable research in improving these properties by alloying additions. The majority of studies in to the effects of additions to RFeB magnets have been made by alloy modification at a pre-casting stage. This is a somewhat inflexible route with many casts being required to investigate the systematic effect of a particular addition on properties. In this work, additions have been made by the powder blending technique. By blending powders prior to sintering a wide range of composing can be assessed rapidly using only a small number of starting alloys. Manufacturers could take advantage of this technique by obtaining a large quantity of a base alloy, and then adjusting its properties accordingly to customer requirements. Pr and Nd-based magnets have been prepared by blending with Co and Al powder. The paper reports the domain structure of as cast alloys, microstructure, magnetic properties and curie temperature of sintered magnets made by blending with Co and Al particles. Magnets were made by varying the Co contents from 0 to 10 at % with both alloys. Al blended magnets of Nd-based alloys were made by varying the Al content from 0 to 3 at %. It has been found that blending is very effective way of adding Co and Al to these alloys. There is an improvement in the curie temperature and magnetic properties of the blended magnets. (author)

  15. Increasing Octane Value in Catalytic Cracking of n-Hexadecane with Addition of *BEA Type Zeolite

    Directory of Open Access Journals (Sweden)

    Iori Shimada

    2015-04-01

    Full Text Available In this study, multifunctional catalysts were developed by adding *BEA or MFI zeolite with high Si/Al ratio to a residual fluidized catalytic cracking (RFCC catalyst and tested in the catalytic cracking of n-hexadecane, which is a heavy crude oil model compound, for the purpose of increasing the octane value of produced gasoline under the strong hydrogen transfer activity of the RFCC catalyst. Reaction products analysis revealed that the addition of *BEA zeolite to the RFCC catalyst increased the yields of olefins and multi-branched paraffins, which resulted in improvement of the octane value without sacrificing gasoline yield. On the contrary, the addition of MFI zeolite decreased the gasoline yield because it cracks the gasoline range olefins into LPG range olefins. In general, it is difficult to increase the yield of multi-branched molecules because the multi-branched molecule is more easily cracked than linear molecules. Our results suggest the possibility for the selective acceleration of isomerization reaction by the addition of less acidic *BEA zeolite to the RFCC catalyst.

  16. Evaluating the Addition of a Dinoflagellate Phytoplankton Functional Type Using Radiance Anomalies for Monterey Bay, CA

    Science.gov (United States)

    Houskeeper, H. F.; Kudela, R. M.

    2016-12-01

    Ocean color sensors have enabled daily, global monitoring of phytoplankton productivity in the world's oceans. However, to observe key structures such as food webs, or to identify regime shifts of dominant species, tools capable of distinguishing between phytoplankton functional types using satellite remote sensing reflectance are necessary. One such tool developed by Alvain et al. (2005), PHYSAT, successfully linked four phytoplankton functional types to chlorophyll-normalized remote sensing spectra, or radiance anomalies, in case-1 waters. Yet this tool was unable to characterize dinoflagellates because of their ubiquitous background presence in the open ocean. We employ a radiance anomaly technique based on PHYSAT to target phytoplankton functional types in Monterey Bay, a region where dinoflagellate populations are larger and more variable than in open ocean waters, and thus where they may be viable targets for satellite remote sensing characterization. We compare with an existing Santa Cruz Wharf photo-pigment time series spanning from 2006 to the present to regionally ground-truth the method's predictions, and we assess its accuracy in characterizing dinoflagellates, a phytoplankton group that impacts the region's fish stocks and water quality. For example, an increase in dinoflagellate abundance beginning in 2005 led to declines in commercially important fish stocks that persisted throughout the following year. Certain species of dinoflagellates in Monterey Bay are also responsible for some of the harmful algal bloom events that negatively impact the shellfish industry. Moving toward better tools to characterize phytoplankton blooms is important for understanding ecosystem shifts, as well as protecting human health in the surrounding areas.

  17. Michael Novak's "Business as a Calling" as a Vehicle for Addressing Ethical and Policy Concerns in a Business Law Course

    Science.gov (United States)

    Murphy, Tonia Hap

    2008-01-01

    This article describes the author's experience of incorporating Michael Novak's "Business as a Calling: Work and the Examined Life" into a Business Law course. The author views it as a positive addition to the course, one that may be of interest to her colleagues at other institutions. Accordingly, after an overview of Novak's analysis in…

  18. Additional value of typing Noroviruses in gastroenteritis outbreaks in Amsterdam, The Netherlands.

    Science.gov (United States)

    Koek, A G; Bovée, L P M J; van den Hoek, J A R; Bos, A J; Bruisten, S M

    2006-02-01

    In Amsterdam, 17 of the 55 gastroenteritis (GI) outbreaks reported from January 2002 to May 2003 were confirmed to be caused by noroviruses (NV). In this study, we describe the molecular epidemiology of a group of nine outbreaks associated with a catering firm and two outbreaks, 5 months apart, in an Amsterdam hospital. All outbreaks were typed to confirm their linkage, and the hospital-related cases were studied to see if the two outbreaks were caused by one persisting NV strain or by a reintroduction after 5 months. For the outbreaks associated with the catering firm one NV genogroup I strain was found which was identical in sequence among customers and employees of the caterer. This was not the strain that predominantly circulated in 2002/2003 in and around Amsterdam, which was the NV genogroup II4 "new variant" (GgII4nv) strain. In the Amsterdam hospital, the two outbreaks were caused by this predominant GgII4nv type, and we argue that NV was most likely reintroduced in the second outbreak from the Amsterdam community.

  19. The General Analytic Solution of a Functional Equation of Addition Type

    OpenAIRE

    Braden, H. W.; Buchstaber, V. M.

    1995-01-01

    The general analytic solution to the functional equation $$ \\phi_1(x+y)= { { \\biggl|\\matrix{\\phi_2(x)&\\phi_2(y)\\cr\\phi_3(x)&\\phi_3(y)\\cr}\\biggr|} \\over { \\biggl|\\matrix{\\phi_4(x)&\\phi_4(y)\\cr\\phi_5(x)&\\phi_5(y)\\cr}\\biggr|} } $$ is characterised. Up to the action of the symmetry group, this is described in terms of Weierstrass elliptic functions. We illustrate our theory by applying it to the classical addition theorems of the Jacobi elliptic functions and the functional equations $$ \\phi_1(x+...

  20. Obituary: Michael John Seaton, 1923-2007

    Science.gov (United States)

    Pradhan, Anil; Nahar, Sultana

    2007-12-01

    Professor Michael John Seaton, hailed as the "Father of Atomic Astrophysics," passed away on May 29, 2007. He was one of the few Honorary Fellows of both the American Astronomical Society and the American Physical Society, so honored for his monumental contributions to both physics and astronomy. Mike Seaton was born on January 16, 1923 in Bristol, England. He attended Wallington County High School. But his leftist political activities, even at that stage, led to his expulsion, though he was eventually allowed to matriculate. He enlisted in the Royal Air Force as a navigator during the Second World War, and flew many dangerous missions. His legendary concentration and precision are reflected in the following anecdote. Once after a bombing mission his aircraft was lost in fog over the Alps. Seaton calculated the position and coordinates in flight to guide the aircraft. When the fog lifted, the crew found themselves flying perilously close to the mountains, but made it safely back. His associates often said, "A Seaton calculation is carried out as if his life depended on it." After the War he was admitted to University College London (UCL) as an undergraduate. Thereafter, he spent all of his professional career at UCL. Seaton received his Batchelor's degree in 1948, and his Ph.D. in 1951. His tenure at UCL coincided with the golden age of atomic astrophysics, for he was largely responsible for it. Seaton was elected Fellow of the Royal Society in 1967, and as President of the Royal Astronomical Society (RAS) in 1978. He was the recipient of an Honorary Doctorate from the Observatoire de Paris, an Honorary D.Sc. from the Queen's University of Belfast, the Gold Medal for Astronomy by the RAS, the Guthrie Medal by the Institute of Physics, the Royal Society Hughes award for lifetime work by the RAS, and several other prestigious awards. Nevertheless, as Alex Dalgarno recently remarked, Seaton was not part of the establishment because he chose not to be. Though rooted in

  1. Stability of a Generalized Euler-Lagrange Type Additive Mapping and Homomorphisms in C∗-Algebras

    Directory of Open Access Journals (Sweden)

    Abbas Najati

    2009-01-01

    Full Text Available Let X,Y be Banach modules over a C∗-algebra and let r1,…,rn∈ℝ be given. We prove the generalized Hyers-Ulam stability of the following functional equation in Banach modules over a unital C∗-algebra: ∑j=1nf(−rjxj+∑1≤i≤n,i≠jrixi+2∑i=1nrif(xi=nf(∑i=1nrixi. We show that if ∑i=1nri≠0, ri,rj≠0 for some 1≤iadditive. As an application, we investigate homomorphisms in unital C∗-algebras.

  2. Organocatalytic Michael and Friedel–Crafts reactions in enantioselective synthesis of biologically active compounds

    International Nuclear Information System (INIS)

    Maltsev, O V; Beletskaya, Irina P; Zlotin, Sergei G

    2011-01-01

    Recent applications of organocatalytic Michael and Friedel–Crafts reactions in enantioselective synthesis of biologically active compounds: natural products, pharmaceutical agents and plant protection agents are reviewed. The key mechanisms of stereoinduction, types of organocatalysts and reagents used in these reactions are considered. The material is classified according to the type of newly formed bonds incorporating the asymmetric carbon atom, and the information for the most numerous C–C coupling reactions is systematized according to the natures of the electrophile and the nucleophile. The bibliography includes 433 references.

  3. Performance Analysis of Window Type Air Conditioning with Addition of Heat Exchanger Equipment

    Directory of Open Access Journals (Sweden)

    I Ketut Gede Wirawan

    2012-11-01

    Full Text Available One manner to be used to increase refregration effect is by flowing hot refrigerant out from condensor, it is then touched with the refrigerant out from evaporator on a heat exchanger of counterflow type. Experiment was done by taking samples of pressure at suction (p1 and discharge (p2 of compressor and box temperature (Tr1, Tr2, Tr3, Tr4. By knowing of pressure at suction (p1, the enthalpy into compressor is known. By assuming the process is isentropic (compressor, isobar (condenser and evaporator, and isenthalpy (expansion valve, the enthalpy into condensor, expansion valve and evaporator were known. In 60 minutes, compression work of air conditioning with heat exchanger is 31,588 kJ/kg, and without heat exchanger is 33,796 kJ/kg. Effect refrigeration average with modification is 155,55 kJ/kg and without modification was 153,40 kJ/kg so that coefficient of performance with modification more than without modification. Air conditioning with modification had initial refrigration rate was 67,193 J/s and 0,043 J/s at the end minute, meanwhile, refrigeration without modification had cooling rate at start 66,538 J/s and 0,935 J/s at the end.

  4. Tweeting Prayers and Communicating Grief over Michael Jackson Online

    Science.gov (United States)

    Sanderson, Jimmy; Cheong, Pauline Hope

    2010-01-01

    Death and bereavement are human experiences that new media helps facilitate alongside creating new social grief practices that occur online. This study investigated how people's postings and tweets facilitated the communication of grief after pop music icon Michael Jackson died. Drawing on past grief research, religion, and new media studies, a…

  5. Professor Porter ja tema viis konkurentsitegurit / Michael E Porter

    Index Scriptorium Estoniae

    Porter, Michael E

    2008-01-01

    Maailmas tuntud juhtimisguru Michael Porter viie konkurentsijõu teooriast ja selle rakendatavusest erinevates valdkondades. Lisad: Erinevused valdkondade kasumlikkuses; 5 määravat konkurentsijõudu; Investeeritud kapitali keskmine tasuvus; Mõnede USA tegevusvaldkondade kasumlikkus; Valdkonnaanalüüs praktikas; Valdkonna määratlemine; Valdkonnaanalüüsi sammud

  6. A Good Time: A Conversation with C. Michael Nelson

    Science.gov (United States)

    Zabel, Robert; Kaff, Marilyn; Teagarden, Jim

    2015-01-01

    C. Michael Nelson began his special education career as a teacher of adolescents with learning and behavior disorders. He has worked as a child psychologist and as a professor with the Department of Special Education and Rehabilitation Counseling at the University of Kentucky. He coordinated the graduate Personnel Preparation Program for Teachers…

  7. Eesti luksushotellide ristiisa / Michael Stenner ; interv. Malle Koido

    Index Scriptorium Estoniae

    Stenner, Michael

    2007-01-01

    Eesti tipphotelle 1997. aastast juhtinud sakslane, praegu hotellide Kolm Õde ja Telegraaf juht räägib Eesti ja Saksamaa erinevustest, Eesti hotelliärist, teeninduskultuurist ja personalist. Lisa: Kes on Michael Stenner ning kuidas ta Eestisse sattus? Ilmunud ka: Linnaleht : Pärnu, 23. veebr. 2007, lk. 5-6

  8. Michael Polanyi on the Education and Knowledge of Scientists.

    Science.gov (United States)

    Jacobs, Struan

    2000-01-01

    Explains why teachers addressing the nature of science should know the work of Michael Polanyi. Outlines Polanyi's intellectual career and examines his ideas on the education of scientists, research, and knowledge. Polanyi presaged Kuhn, Feyerabend, and the constructivists, yet insisted that science produces true knowledge about reality. (Contains…

  9. Michael Moore kaevati kohtusse pettuse eest / Mari Rebane

    Index Scriptorium Estoniae

    Rebane, Mari

    2006-01-01

    Dokumentaalfilm "9/11 Fahrenheiti" ("Fahrenheit 9/11") : režissöör Michael Moore : USA 2004. Iraagi sõja invaliidistunud veteran andis režissööri kohtusse teda kujutavate flmikaadrite loata ja tenentsliku kasutamise pärast

  10. Berliinis võidutses Michael Haneke / Jüri Laulik

    Index Scriptorium Estoniae

    Laulik, Jüri, 1959-

    2005-01-01

    IX PÖFFil linastuv Michael Haneke film "Varjatud" ("Cache") võitis laupäeval mitu Euroopa Filmiakadeemia auhinda, sealhulgas parima filmi, parima lavastaja ja parima meesnäitleja (Daniel Auteuil) auhinna. Parima naisnäitleja tiitli pälvis Julia Jentsch ("Sophie Scholli viimased päevad"). Elutööpreemia sai sir Sean Connery

  11. Educational Implications of Michael Fishbane's "Sacred Attunement: A Jewish Theology"

    Science.gov (United States)

    Marom, Daniel

    2008-01-01

    This article posits Michael Fishbane's Judaic scholarship as a prime resource for Jewish education. The link between the two fields can be made through a translation of the theological underpinnings of Fishbane's insights into Judaism to educational purposes and practices. Initial work with Jewish educators on establishing this link encouraged…

  12. Correspondence of Michael Faraday, v.5 1855-1860

    CERN Document Server

    Faraday, Michael

    2008-01-01

    This volume includes 70% of previously unpublished letters of Michael Farday spanning half of the 1850s and most of 1860. Topics include Faraday's work on regelation, the transmission of light through gold and his appointment by Emperor Napoleon III to be a Commander of the Legion of Honour.

  13. A Fluorescent Molecular Probe for the Detection of Hydrogen Based on Oxidative Addition Reactions with Crabtree-Type Hydrogenation Catalysts.

    Science.gov (United States)

    Kos, Pavlo; Plenio, Herbert

    2015-11-02

    A Crabtree-type Ir(I) complex tagged with a fluorescent dye (bodipy) was synthesized. The oxidative addition of H2 converts the weakly fluorescent Ir(I) complex (Φ=0.038) into a highly fluorescent Ir(III) species (Φ=0.51). This fluorogenic reaction can be utilized for the detection of H2 and to probe the oxidative addition step in the catalytic hydrogenation of olefins. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Effect of the addition of different types of oenological commercial tannins on phenolic and sensorial red wine characteristics evolution

    OpenAIRE

    Jordão, António; Muxagata, Sara; Fontes, Luísa; Correia, Ana Cristina; Nunes, Fernando; Cosme, Fernanda

    2016-01-01

    The main objective of this work was to understand the effect of the addition of different commercial types of oenological tannins on red wine phenolic compounds and sensorial characteristics evolution. So, six different commercial oenological tannins obtained from different sources at an average dosage recommended by the manufactures were added to a red wine. During 120 wine aging days several phenolic parameters were analyzed (including several individual phenolic compounds by HPLC) and also...

  15. Isolated and modulated effects of topology and material type on the mechanical properties of additively manufactured porous biomaterials.

    Science.gov (United States)

    Hedayati, R; Ahmadi, S M; Lietaert, K; Pouran, B; Li, Y; Weinans, H; Rans, C D; Zadpoor, A A

    2018-03-01

    In this study, we tried to quantify the isolated and modulated effects of topological design and material type on the mechanical properties of AM porous biomaterials. Towards this aim, we assembled a large dataset comprising the mechanical properties of AM porous biomaterials with different topological designs (i.e. different unit cell types and relative densities) and material types. Porous structures were additively manufactured from Co-Cr using a selective laser melting (SLM) machine and tested under quasi-static compression. The normalized mechanical properties obtained from those structures were compared with mechanical properties available from our previous studies for porous structures made from Ti-6Al-4V and pure titanium as well as with analytical solutions. The normalized values of elastic modulus and yield stress were found to be relatively close to each other as well as in agreement with analytical solutions regardless of material type. However, the material type was found to systematically affect the mechanical properties of AM porous biomaterials in general and the post-elastic/post-yield range (plateau stress and energy absorption capacity) in particular. To put this in perspective, topological design could cause up to 10-fold difference in the mechanical properties of AM porous biomaterials while up to 2-fold difference was observed as a consequence of changing the material type. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Additional Types of Neuropathy

    Science.gov (United States)

    ... Recipe Kits Delivered We've teamed up with Chef'd to bring you healthy recipe kits. Ways ... Us Policies Corporate Support Newsroom Press Releases For Professionals En Español Online Community Walk Bike Shop Sign ...

  17. Michael Pärt ئ suure muusika taustajõud / Michael Pärt ; interv. Siim Nestor

    Index Scriptorium Estoniae

    Pärt, Michael

    2008-01-01

    Arvo Pärdi pojast Michael Pärdist. Tema tööst "music editor"-ina - helimonteerijana, tööst muusika produktsiooni, salvestamise ja muusika kirjutamise abijõuna. Koostööst maailmas tuntud muusikutega

  18. CFD Analysis of the Oscillating Flow within a Stirling Engine with an Additively Manufactured Foil Type Regenerator

    Science.gov (United States)

    Qiu, Songgang; Solomon, Laura

    2017-11-01

    The simplistic design, fuel independence, and robustness of Stirling convertors makes them the ideal choice for use in solar power and combined heat and power (CHP) applications. A lack of moving parts and the use of novel flexure bearings allows free-piston type Stirling engines to run in excess of ten years without degradation or maintenance. The key component to their overall efficiency is the regenerator. While a foil type regenerator outperforms a sintered random fiber regenerator, limitation in manufacturing and keeping uniform spacing between the foils has limited their overall use. However, with the advent of additive manufacturing, a robust foil type regenerator can be cheaply manufactured without traditional limitations. Currently, a CFD analysis of the oscillating internal flow within the novel design was conducted to evaluate the flow loses within the system. Particularly the pressure drop across the regenerator in comparison to a traditionally used random fiber regenerator. Additionally, the heat transfer and flow over the tubular heater hear was evaluated. The results of the investigation will be used to optimize the operation of the next generation of additively manufactured Stirling convertors. This research was supported by ARPA-E and West Virginia University.

  19. The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive

    DEFF Research Database (Denmark)

    Falskov, Britt; Hermann, Thomas Steffen; Rask-Madsen, Christian

    2011-01-01

    AIM: Chronic heart failure is associated with endothelial dysfunction and insulin resistance. The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes. ME...... in similar vascular insulin resistance and reduced muscular insulin-stimulated glucose uptake. The effects of systolic heart failure and type 2 diabetes appear to be additive.......AIM: Chronic heart failure is associated with endothelial dysfunction and insulin resistance. The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes...

  20. Effect of static mixer on the performance of compact plate heat exchanger with zwitterionic type of drag-reducing additives

    Energy Technology Data Exchange (ETDEWEB)

    Blais, C.; Wollerstrand, J.

    1997-06-01

    The main task of the project was to investigate the influence of drag-reducing additives (DRA) dissolved in circulating hot water on heat transfer in compact plate heat exchangers (PHE). Furthermore the result of flow disturbance (static mixing) immediately before the PHE on pressure drop and heat transfer was clarified. The project used a new type of DRA (surfactants of zwitterionic type) for two different temperature ranges. A dedicated test rig, `Ansgar`, was built for the purpose. Good thermal and mechanical stability also outside the operating range was observed except some sensitivity for water hardness at high temperatures for DRA2. Similarly to known investigations, the heat transfer coefficient was significantly reduced by DRA in heat exchangers. In PHE used however, the heat transfer reduction was considerably lower in the high flow region. A static mixer placed in front of the PHE was found to significantly improve heat transfer, especially at high flow rates. On the other hand, an additional pressure drop was introduced. Therefore the optimal choice of static mixer needs further investigation. Specially designed PHE combining mixing and heat transfer functions could be beneficial to reducing the effects of additives in thermal systems. The relaxation time (RT) of drag-reducing additives in water solutions flowing through test pipes with known geometries was estimated by monitoring specific pressure drop variation along the pipe. These preliminary experiments in respect to relaxation time showed that RT depends on the flow rate and on the temperature 12 refs, 11 figs, 1 tab

  1. The influences of sulphur and phosphorus additions on the creep cavitation characteristics in type 304 stainless steels

    International Nuclear Information System (INIS)

    Jun Hwa Hong; Soo Woo Nam; Sun Pil Choi

    1986-01-01

    The effects of impurities on creep cavitation characteristics in type 304 stainless steels with and without additions of sulphur and/or phosphorus have been studied using four experimental heats. Over a limited range of stress at 1000 K, the change in size distribution of creep cavities and carbide precipitates, and the level of impurity segregation with the amount of addition have been investigated. It is found that phosphorus accelerates the nucleation of creep cavities, but retards the growth of them. However, sulphur had little effect on both nucleation and growth of the cavities. It has also been found that ageing prior to testing inhibits creep cavitation. The effects of impurities on cavitation are analysed and discussed from the viewpoint of the change in the segregation of impurities and the precipitation of carbides due to impurity additions. (author)

  2. Pengaruh Tipografi pada Era Massimo Vignelli terhadap Tipografi Michael Bierut

    Directory of Open Access Journals (Sweden)

    Irwan Harnoko

    2011-10-01

    Full Text Available Massimo Vignelli is a senior graphic designer lived in New York, as a vocal modernism against post-modernism. His statement firmly opposing post-modernism in several occasions: interview in Helvetica the movie, typeradio, talkshow, and some articles in Looking Closer or AIGA Journal. Graphic design works of Massimo Vignelli reflected his characteristic, which is firmly choosing typeface. Typefaces of Vignelly are around 5 typefaces: Bodoni, Helvetica, Times Roman, Century, and Futura. The article uses formal analysis method. The writers collected materials about Michael Bierut, Massimo VIgnelli and Tibor Kalman from books and websites. The writers compare the typeface opinion of Massimo Vignelli (modernism designer, Michael Bierut designer (transition era designer from modernism to post-modernism, and Tibor Kalman (a designer in A Century of Graphic Design, as the influencer of Bierut’s betrayal over Vignelli. 

  3. Tribute to Professor Anthony J. McMichael

    Directory of Open Access Journals (Sweden)

    Ashwin Swaminathan

    2014-11-01

    Full Text Available Emeritus Professor A. J. “Tony” McMichael (1942–2014 was an internationally renowned and pioneering Australian academic and advocate in epidemiology, who was passionate about understanding the influences of the environment on human health. In an illustrious career spanning more than four decades, he made significant contributions to the scientific community and policy discourse—including ground-breaking research related to the health of children. McMichael was a prolific academic writer with over 300 peer-reviewed papers; 160 book chapters and two sole-authored books. However, his outstanding talent was for integrating complex and seemingly unrelated strands from the environmental and health sciences into a cohesive narrative—and highlighting its relevance to lay persons, scientists and governments alike. He was instrumental in validating this nascent field of research and inspiring many others to follow his lead.

  4. The prevalence of diabetic retinopathy in patients with screen-detected type 2 diabetes in Denmark: the ADDITION study

    DEFF Research Database (Denmark)

    Bek, Toke; Lund-Andersen, Henrik; Hansen, Anja Bech

    2009-01-01

    . There was no significant difference between age, sex and visual acuity among patients with and without retinopathy. However, the patients with retinopathy had significantly higher HbA1c and systolic and diastolic blood pressure than the patients without retinopathy. CONCLUSION: Patients with screen-detected diabetes have......BACKGROUND: The prevalence of type 2 diabetes is increasing, but the exact prevalence of the disease and its accompanying late complications are unknown. In the Anglo-Danish-Dutch study of Intensive Treatment in People with Screen-detected Diabetes in Primary Care (ADDITION study), patients...... with hitherto undiagnosed type 2 diabetes are identified using a stepwise screening strategy in selected general practices. This article reports the occurrence of diabetic retinopathy in this population. METHODS: In Arhus and Copenhagen counties, a total of 12,708 of the persons invited by mail were screened...

  5. Political Cinema and Culture industry: the work of Michael Moore

    OpenAIRE

    Cristiane Toledo Maria

    2015-01-01

    This article aims to reflect upon the production of the American filmmaker Michael Moore, proposing as a central question the relationship established between art and politics in a historical moment which, on one side, points to the crisis of capitalism and, on the other side, to the political fragmentation of the working class. Focusing on the analysis of the documentaries Roger & Me (1989) and Capitalism: a love story (2009), this article is an attempt to understand the method developed by ...

  6. Entretien avec Michael Quinn Patton | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    9 févr. 2011 ... Michael Quinn Patton, évaluateur de renommée internationale, était récemment au CRDI .... C'est un mode de pensée analytique qui doit tout imprégner. ... des données solides et crédibles sur ce qui marche et ce qui ne marche pas. ... des emplois, des infrastructures et un accès à la nourriture et aux mar.

  7. Euroopa parimaks filmiks sai Michael Haneke "Valge lint" / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2009-01-01

    Euroopa Filmiakadeemia auhindadest: parima filmiauhinna sai Saksamaal Bochumis toimunud tseremoonial Michael Haneke "Valge lint", mille eest Haneke sai ka parima režissööri ja stsenaristi auhinna. Parimaks meesnäitlejaks pärjati Tahar Rahim ("Un Prophete"), parimaks naisnäitlejaks Kate Winslet ("The Reader"), publikupreemia sai Danny Boyle'i "Rentslimiljonär. Ka teistest võitjatest

  8. Additive glucose-lowering effects of glucagon-like peptide-1 and metformin in type 2 diabetes

    DEFF Research Database (Denmark)

    Zander, M; Taskiran, M; Toft-Nielsen, M B

    2001-01-01

    ) alternating with GLP-1 (continuous subcutaneous infusion of 2.4 pmol x kg(-1) x min(-1)) alternating with a combination of metformin and GLP-1 for 48 h. Under fixed energy intake, we examined the effects on plasma glucose, insulin, C-peptide, glucagon, and appetite. RESULTS: Fasting plasma glucose (day 2...... this study to investigate the effect of a combination therapy with GLP-1 and metformin, which could theoretically be additive, in type 2 diabetic patients. RESEARCH DESIGN AND METHODS: In a semiblinded randomized crossover study, seven patients received treatment with metformin (1,500 mg daily orally......) and 11.7 +/- 0.8 (GLP-1) to 9.8 +/- 0.5 (combination) (P = 0.02, no difference between GLP-1 and metformin). Insulin levels were similar between the three regimens, but glucagon levels were significantly reduced with GLP-1 compared with metformin (P = 0.0003). Combination therapy had no additional effect...

  9. Using special additions to preparation of the moulding mixture for casting steel parts of drive wheel type

    Science.gov (United States)

    Josan, A.; Pinca Bretotean, C.

    2015-06-01

    The paper presents the possibility of using special additions to the execution of moulding mixtures for steel castings, drive wheel type. Critical analysis of moulding technology leads to the idea that most defects appear due to using improper moulding mixture. Using a improper moulding mixture leads to penetration of steel in moulding mixture, resulting in the formation of adherences, due to inadequate refractarity of the mould and core mixtures. Using only the unique mixture to the moulding leads to increasing consumption of new sand, respectively to the increase of price of piece. Acording to the dates registered in the industrial practice is necessary to use the special additions to obtain the moulding mixtures, carbonaceous materials respectively.

  10. The Quality of Edible Film Made from Nile Tilapia (Oreochromis niloticus) Skin Gelatin with Addition of Different Type Seaweed Hydrocolloid

    Science.gov (United States)

    Deanti, H.; Hulu, J. M.; Setyaji, A.; Eliyanti, R. N.; Aliya, K.; Dewi, E. N.

    2018-02-01

    The functional properties of fish skin’s gelatin lower than mammals, hence the gelatin proteins needed a polysaccharides hydrocolloids to form a continuous and more cohesive network of edible film. Polysaccharides hydrocolloid (carrageenan, agar and alginate) containing phenol compounds was oxidized to be converted into quinone and it was expected to act as a cross linking agent. The purpose of this study was to determine the characteristics (thickness, tensile strength, elongation, solubility and water vapour transmition rate) of edible film made from nile tilapia skin gelatin by adding different type polyssacharide hydrocolloid. Edible film was made by mixture of gelatin 5 g and addition of carrageenan (C1), agar (C2), alginate (C3) concentration ; 0,5% (v/w), all the materials were poured into 100 ml destilled water that containing 10% glycerol (w/w). The solution was then heated on a hot plate stirer at 40°C for 30 min and dehydrated in a oven at 50°C. All data were analysed using ANAVA. Based on the result it can be seen that the addition of oxidized polisacarides hydrocolloid have a significant effect on tensile strength (TS), water vapor transmision rate, solubility and elongation at break properties, but did not in thickness. Edible film gelatin with the addition of alginate has better characteristics viewed by tensile strength (23.05 Kgf/cm2), water vapor transmission rate (0.61 gram/m2/hour) and thickness (0.16 mm) than carrageenan and agar.

  11. Effect of the addition of different types of oenological commercial tannins on phenolic and sensorial red wine characteristics evolution

    Directory of Open Access Journals (Sweden)

    Jordão António M.

    2016-01-01

    Full Text Available The main objective of this work was to understand the effect of the addition of different commercial types of oenological tannins on red wine phenolic compounds and sensorial characteristics evolution. So, six different commercial oenological tannins obtained from different sources at an average dosage recommended by the manufactures were added to a red wine. During 120 wine aging days several phenolic parameters were analyzed (including several individual phenolic compounds by HPLC and also the sensorial characteristics of the wines. Wines treated with oenological tannins showed higher total phenols and flavonoid phenols and lesser color degradation during the aging time considered. After 120 aging days, wines aged with oenological tannins showed more total and individual anthocyanins and significantly more red color that induced significantly color differences in relation to the untreated wine (especially for the wines treated with condensed tannins. From a sensorial point of view it was also possible to detect a clear differentiation between the wines.

  12. Ethylene bis-carbonates as telltales of SEI and electrolyte health, role of carbonate type and new additives

    International Nuclear Information System (INIS)

    Kim, Huikyong; Grugeon, Sylvie; Gachot, Grégory; Armand, Michel; Sannier, Lucas; Laruelle, Stéphane

    2014-01-01

    The ethylene bis-carbonate compounds formation is responsible for the earliest change in electrolyte composition which can be one of the reasons for battery performance decay. In this study, liquid GC/MS technique is used to detect their formation in electrolytes based on solvent mixtures of EC and different linear carbonates (DMC, DEC and EMC), after the first cycle in full cells composed of synthetic graphite powder/commercial positive films. These compounds stem from linear carbonate electrochemical reduction leading to alkoxide compounds and can be quantified using a selective bicyclic boron ester Lewis acid as an electrolyte additive. Moreover, a quantitative study on ethylene bis-carbonate compounds for which the generation profile is different depending on the linear carbonate type, shows that either in batteries or in a simple chemical mixture of electrolyte and lithium alkoxide, their formation stops when it reaches a threshold concentration due to the thermodynamic equilibrium. The overall information is useful for investigating the passivation ability and the dissolution of the Solid Electrolyte Interphase (SEI) that is formed on the negative electrode material. Finally, the passivation property of the SEI freshly formed with four additives - Vinylene Carbonate (VC), Vinyl Ethylene Carbonate (VEC), Fluoro Ethylene Carbonate (FEC) and 1,3-Propane Sultone (1,3-PS)- is studied

  13. How do peat type, sand addition and soil moisture influence the soil organic matter mineralization in anthropogenically disturbed organic soils?

    Science.gov (United States)

    Säurich, Annelie; Tiemeyer, Bärbel; Don, Axel; Burkart, Stefan

    2017-04-01

    Drained peatlands are hotspots of carbon dioxide (CO2) emissions from agriculture. As a consequence of both drainage induced mineralization and anthropogenic sand mixing, large areas of former peatlands under agricultural use contain soil organic carbon (SOC) at the boundary between mineral and organic soils. Studies on SOC dynamics of such "low carbon organic soils" are rare as the focus of previous studies was mainly either on mineral soils or "true" peat soil. However, the variability of CO2 emissions increases with disturbance and therefore, we have yet to understand the reasons behind the relatively high CO2 emissions of these soils. Peat properties, soil organic matter (SOM) quality and water content are obviously influencing the rate of CO2 emissions, but a systematic evaluation of the hydrological and biogeochemical drivers for mineralization of disturbed peatlands is missing. With this incubation experiment, we aim at assessing the drivers of the high variability of CO2 emissions from strongly anthropogenically disturbed organic soil by systematically comparing strongly degraded peat with and without addition of sand under different moisture conditions and for different peat types. The selection of samples was based on results of a previous incubation study, using disturbed samples from the German Agricultural Soil Inventory. We sampled undisturbed soil columns from topsoil and subsoil (three replicates of each) of ten peatland sites all used as grassland. Peat types comprise six fens (sedge, Phragmites and wood peat) and four bogs (Sphagnum peat). All sites have an intact peat horizon that is permanently below groundwater level and a strongly disturbed topsoil horizon. Three of the fen and two of the bog sites have a topsoil horizon altered by sand-mixing. In addition the soil profile was mapped and samples for the determination of soil hydraulic properties were collected. All 64 soil columns (including four additional reference samples) will be installed

  14. Michael Kohlhaas or the Germans and Their Law

    Directory of Open Access Journals (Sweden)

    Heike Jung

    2014-12-01

    Full Text Available Asked to pick a single representative ‘German’ piece for a discourse on ‘Law and Literature’ one almost inevitably ends up with Kleist’s tale Michael Kohlhaas. It seems to be the literary incarnation of the German stance vis-à-vis the law. It is all about horses; it could just as well be about dogs. Kohlhaas fights a devastating battle, using legal means and outright violence, even warfare, for their recovery in good shape. Victorious eventually with his legal actions, he is happy to trade in his own life for this victory, thus giving an extreme example for the nice line between being in the right and pursuing this position with disproportionate rigour. Of course, the interpretations of Michael Kohlhaas (which, in its complete version, dates of 1810 have varied from epoch to epoch as well as from reader to reader. It is not possible to rehearse the bulk of ‘Kohlhaas literature’. In comparing legal cultures, it might be of interest to look into the question why such a somber story on the law forms part and will continue to form part of the German cultural heritage. Si se tiene que elegir un único representante “alemán” para una ponencia sobre “derecho y literatura”, es inevitable optar por la obra de Kleist, Michael Kohlhaas. Parece la encarnación literaria de la posición alemana hacia el derecho. El libro trata de caballos; también podría tratar sobre perros. Kohlhaas libra una batalla devastadora usando medios legales y la violencia pura y dura, incluso la guerra, para que se recuperen en buena forma. Finalmente resulta ganador mediante acciones legales, está contento de dedicar su propia vida para conseguir esta victoria, dando así un ejemplo extremo de la línea que existe entre tener la razón y seguir esta posición con un rigor desproporcionado. Por supuesto, las interpretaciones de Michael Kohlhaas (publicado en 1810 han variado de una época a otra, y de un lector a otro. No es posible revisar el grueso de

  15. The Correspondence of Michael Faraday Pt 6 1860-1867

    CERN Document Server

    Frank, James

    2012-01-01

    Michael Faraday (1791-1867) was one of the most important men of science in nineteenth century Britain. His discoveries of electro-magnetic rotations (1821) and electro-magnetic induction (1831) laid the foundations of the modern electrical industry. His discovery of the magneto-optical effect and diamagnetism (1845) led him to formulate the field theory of electro-magnetism, which forms one of the cornerstones of modern physics.These and a whole host of other fundamental discoveries in physics and chemistry, together with his lecturing at the Royal Institution, his work for the state (includi

  16. Michael Marinov memorial volume multiple facets of quantization and supersymmetry

    CERN Document Server

    Vainshtein, A I

    2002-01-01

    This book is dedicated to the memory of Michael Marinov, the theorist who, together with Felix Berezin, introduced the classical description of spin by anticommuting Grassmann variables. It contains original papers and reviews by physicists and mathematicians written specifically for the book. These articles reflect the current status and recent developments in the areas of Marinov's research: quantum tunneling, quantization of constrained systems, supersymmetry, and others. The personal recollections included portray the human face of M Marinov, a person of great knowledge and integrity.

  17. Enantioselective desymmetrization of prochiral cyclohexanones by organocatalytic intramolecular Michael additions to α,β-unsaturated esters.

    Science.gov (United States)

    Gammack Yamagata, Adam D; Datta, Swarup; Jackson, Kelvin E; Stegbauer, Linus; Paton, Robert S; Dixon, Darren J

    2015-04-13

    A new catalytic asymmetric desymmetrization reaction for the synthesis of enantioenriched derivatives of 2-azabicyclo[3.3.1]nonane, a key motif common to many alkaloids, has been developed. Employing a cyclohexanediamine-derived primary amine organocatalyst, a range of prochiral cyclohexanone derivatives possessing an α,β-unsaturated ester moiety linked to the 4-position afforded the bicyclic products, which possess three stereogenic centers, as single diastereoisomers in high enantioselectivity (83-99% ee) and in good yields (60-90%). Calculations revealed that stepwise C-C bond formation and proton transfer via a chair-shaped transition state dictate the exclusive endo selectivity and enabled the development of a highly enantioselective primary amine catalyst. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Studies on NaI/DMSO induced retro-Michael addition (RMA ...

    Indian Academy of Sciences (India)

    Unknown

    e-mail: hspr@yahoo.com. MS received 5 August .... evaluate the electronic influence of substituents on the aromatic ..... SJ thanks Council of Scientific and Industrial Res- earch, New Delhi ... thesis 1037; (c) Nelson J H, Howells P N, DeLullo G.

  19. Inverting the diastereoselectivity of the mukaiyama-michael addition with graphite-based catalysts

    KAUST Repository

    Acocella, Maria Rosaria; Mauro, Marco; Falivene, Laura; Cavallo, Luigi; Guerra, Gaetano

    2014-01-01

    , the graphite-based catalysts described here invert the diastereoselectivity relative to that observed with known catalysts, with the unprecedented large prevalence of the anti diastereoisomer. This inverted diastereoselectivity is increased when the catalyst

  20. Novel in situ forming, degradable dextran hydrogels by michael addition chemistry: synthesis, rheology, and degradation

    NARCIS (Netherlands)

    Hiemstra, C.; van der Aa, L.J.; Zhong, Zhiyuan; Dijkstra, Pieter J.; Feijen, Jan

    2007-01-01

    Various vinyl sulfone functionalized dextrans (dex-VS) (Mn,dextran = 14K or 31K) with degrees of substitution (DS) ranging from 2 to 22 were conveniently prepared by a one-pot synthesis procedure at room temperature. This procedure involved reaction of a mercaptoalkanoic acid with an excess amount

  1. Well-defined single-chain polymer nanoparticles via thiol-Michael addition

    NARCIS (Netherlands)

    Kröger, A. Pia P.; Boonen, Roy J.E.A.; Paulusse, Jos M.J.

    2017-01-01

    A synthetic strategy has been developed giving facile access to well-defined single-chain polymer nanoparticles (SCNPs) from styrene-, acrylate- and methacrylate-based polymers. Random copolymers (polydispersity indices 1.10–1.15) of methyl (meth)acrylate, benzyl methacrylate or styrene containing

  2. Study of sorption of two sulfonylurea type of herbicides and their additives on soils and soil components.

    Science.gov (United States)

    Földényi, Rita; Tóth, Zoltán; Samu, Gyöngyi; Érsek, Csaba

    2013-01-01

    The sorption of two sulfonylurea type herbicides (chlorsulfuron: (1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea; tribenuron methyl: (methyl-2-[N-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-3-(methyl-ureido)-sulfonyl]-benzoate) was studied on sand and chernozem soil adsorbents. Experimental results for solutions prepared from the pure ingredients were compared to those prepared from the appropriate formulated commercial products. At small concentrations, the extent of adsorption of the active ingredient was higher than from the formulation containing solutions. Environmental fate and effects of the forming agents are less investigated because they rarely have concentration limits recommended by authorities. In addition to the adsorption of active ingredients, therefore, the sorption behavior of a widely used additive Supragil WP (sodium diisopropyl naphthalene sulphonate) was also studied. This dispersant is an anionic forming agent applied in a lot of pesticide formulations. Using three different soils (sand, brown forest, chernozem) as adsorbents two-step isotherms were obtained. The role of the soil organic matter (OM) was significant in the adsorption mechanism because the adsorbed amounts of the dispersant correlated with the specific surface area as well as with the total organic carbon (TOC) content of the soils. The sorption behavior indicates the operation of hydrophobic interaction mechanism between the soil OM and the dispersant. These results are supported by our further sorption experiments on clays, too. Zeta potential measurements seem to be promising for the interpretation of multi-step isotherms. The application of this technique proved that higher concentrations of the anionic forming agent assisted the peptization of soil organic matter (SOM) resulting in stable colloidal solution dominated by negative charges. Since the pesticides investigated are also anionic at the studied pH (7 and 8.3) the dissolved organics lead to the

  3. Stereoselective synthesis of organosulfur compounds incorporating N-aromatic heterocyclic motifs and quaternary carbon centers via a sulfa-Michael triggered tandem reaction.

    Science.gov (United States)

    Qin, Tianyou; Cheng, Lu; Zhang, Sean Xiao-An; Liao, Weiwei

    2015-06-14

    A novel sulfa-Michael addition (SMA)-triggered tandem reaction was developed by combining a SMA reaction with a simultaneous rearomatization process utilizing a less reactive carbonyl group as an intramolecular electrophile partner, which provided a unique synthetic route to access various organosulfur compounds incorporating an N-aromatic heterocyclic motif and quaternary carbon centers.

  4. [Assessment of efficiency of dietotherapy with addition of a vitamin-mineral complex in patients with diabetes mellitus type 2].

    Science.gov (United States)

    Lapik, I A; Sokol'nikov, A A; Sharafetdinov, Kh Kh; Sentsova, T B; Plotnikova, O A

    2014-01-01

    The influence of diet inclusion of vitamin and mineral complex (VMC), potassium and magnesium in the form of asparaginate on micronutrient status, body composition and biochemical parameters in patients with diabetes mellitus type 2 (DM2) has been investigated. 120 female patients with DM2 and obesity of I-III degree (mean age - 58 +/- 6 years) have been included in the study. The patients were divided into two groups: main group (n = 60) and control group (n = 60). For 3 weeks patients of both groups received a low-calorie diet (1600 kcal/day). Patients of the main group received VMC, providing an additional intake of vitamins C and E (100-120% RDA), beta-carotene (40% RDA), nicotinamide (38% RDA), pantothenic acid and biotin (60% RDA), vitamins B12, B2 and folic acid (75-83% RDA), vitamins B1 and B6 (160-300% RDA), zinc (100% RDA) and chromium (400% RDA), and also received magnesium (17.7% RDA) and potassium (9.4% RDA) in the form of asparaginate. Body composition, biochemical parameters and micronutrient status (blood serum level of vitamins C, D, B6, B12, folate, potassium, calcium, magnesium, zinc, phosphorus) were evaluated in all patients before and after the 3-week course of diet therapy. After the low-calorie diet therapy average body weight reduction was 4.2 +/- 0.2 kg in the main group, and 4.4 +/- 0.1 kg in the control group, without statistically significant differences between groups. Statistically significant decrease of total cholesterol, triglycerides, and glucose concentration in blood serum was registered in both groups. It should be noted that in the control group glycemia decreased on 1.2 +/- 0.1 mmol/l, while the main group showed a decrease on 1.8 +/- 0.1 (p l). Initial assessment of vitamin and mineral status revealed that most patients were optimal supplied with vitamins and minerals. After the dietotherapy significant increase of vitamin C, 25-hydroxyvitamin D, vitamin B6, folate, vitamin B12, potassium, magnesium, calcium, zinc and

  5. Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control

    Directory of Open Access Journals (Sweden)

    Di Pierro F

    2012-07-01

    Full Text Available Francesco Di Pierro,1 Nicola Villanova,2 Federica Agostini,2 Rebecca Marzocchi,2 Valentina Soverini,2 Giulio Marchesini21Scientific Department, Velleja Research, Milano, 2Diseases of Metabolism, S Orsola Malpighi Hospital, Bologna, ItalyBackground: Suboptimal glycemic control is a common situation in diabetes, regardless of the wide range of drugs available to reach glycemic targets. Basic research in diabetes is endeavoring to identify new actives working as insulin savers, use of which could delay the introduction of injectable insulin or reduce the insulin dose needed. Commonly available as a nutraceutical, berberine is a potential candidate.Methods and results: Because its low oral bioavailability can be overcome by P-glycoprotein inhibitors like herbal polyphenols, we have tested the nutraceutical combination of Berberis aristata extract and Silybum marianum extract (Berberol® in type 2 diabetes in terms of its additive effect when combined with a conventional oral regimen for patients with suboptimal glycemic control. After 90 days of treatment, the nutraceutical association had a positive effect on glycemic and lipid parameters, significantly reducing glycosylated hemoglobin, basal insulin, homeostatic model assessment of insulin resistance, total and low-density lipoprotein cholesterol, and triglycerides. A relevant effect was also observed in terms of liver function by measuring aspartate transaminase and alanine transaminase. The product had a good safety profile, with distinctive gastrointestinal side effects likely due to its acarbose-like action.Conclusion: Although further studies should be carried out to confirm our data, Berberol could be considered a good candidate as an adjunctive treatment option in diabetes, especially in patients with suboptimal glycemic control.Keywords: berberine, silymarin, glycosylated hemoglobin, diabetes

  6. A Study of Postmodern Narrative in Michael Cunningham's The Hours

    Directory of Open Access Journals (Sweden)

    Hajar Abbasi Narinabad

    2012-09-01

    Full Text Available This project aims at providing a detailed analysis of the major features of the theory of postmodern narrative and at going through the novel The Hours by the American writer Michael Cunningham concentrating on some postmodern narrative techniques. To do so, the researcher goes through the theories set forth by some postmodern theoreticians like Roland Barthes, Jacque Derrida, Jean-François Lyotard and Julia Kristeva to investigate the postmodern narrative techniques and elements used in the novel. The researcher first examines the theories and then critically applies them on the novel. The article goes through the most eminent elements of postmodern narrative including intertextuality, stream of consciousness style, fragmentation and representation respectively which are delicately utilized in The Hours. The article concludes by recommending a few directions for the further research.

  7. Michael Longley’s Father: Memory, Mourning and History

    Directory of Open Access Journals (Sweden)

    Barry Sloan

    2012-03-01

    Full Text Available Michael Longley’s father has been a recurring presence in the poet’s work from his earliest to his most recent collection. This paper examines the exceptional strength of that bond reflected in the varied and changing ways in which the poet has responded to it – memorizing and mourning his loss; discovering through his father’s First World War stories a means of memorialising loss of life in contemporary conflicts and a way of facing the history of the twentieth century; confronting his own ageing and sense of mortality; and marking the specific, but also representative, generational history of his family. Close readings of key poems are offered to highlight Longley’s skills in meeting his own exacting standards of aesthetic propriety and moral and social responsibility for writers of elegy in order to avoid either exploitation of tragedy and loss, or facile gestures of consolation.

  8. Estratégia competitiva: Michael Porter 30 anos depois

    Directory of Open Access Journals (Sweden)

    Manuel Portugal Ferreira

    2009-12-01

    Full Text Available Os estudos de estratégia têm sido muito influenciados pelos trabalhos de Michael Porter, em todas as suas fases, como as cinco forças, as estratégias genéricas, a cadeia de valor e as vantagens competitivas das nações. Neste artigo, analisou-se a influência de Porter nos trabalhos brasileiros em estratégia, a partir dos trabalhos selecionados e apresentados no EnANPAD. No levantamento para a análise dos artigos, considerando 10 anos de EnANPAD (1997-2006, foram selecionados 46 artigos. A identificação e seleção dos artigos envolveram os seguintes critérios: busca complementar por palavra-chave Porter na base de dados do EnANPAD; avaliação dos títulos e resumos dos artigos apresentados na área de estratégia entre 1997 e 2006, bem como na íntegra quando necessário. Procedeu-se também à análise das referências utilizadas nos artigos e o posicionamento dos autores em relação às tipologias de Porter. Como resultado, verificou-se que Michael Porter é um autor com grande influência nas pesquisas acadêmicas de estratégia. Seus estudos mais utilizados são os da análise da indústria e das estratégias genéricas, e também se verificou que a maioria dos estudos analisados é favorável aos seus conceitos, mesmo existindo pesquisas contrárias.

  9. Multiple behaviour change intervention and outcomes in recently diagnosed type 2 diabetes: the ADDITION-Plus randomised controlled trial.

    Science.gov (United States)

    Griffin, Simon J; Simmons, Rebecca K; Prevost, A Toby; Williams, Kate M; Hardeman, Wendy; Sutton, Stephen; Brage, Søren; Ekelund, Ulf; Parker, Richard A; Wareham, Nicholas J; Kinmonth, Ann Louise

    2014-07-01

    The aim of this study was to assess whether or not a theory-based behaviour change intervention delivered by trained and quality-assured lifestyle facilitators can achieve and maintain improvements in physical activity, dietary change, medication adherence and smoking cessation in people with recently diagnosed type 2 diabetes. An explanatory randomised controlled trial was conducted in 34 general practices in Eastern England (Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen Detected Diabetes in Primary Care-Plus [ADDITION-Plus]). In all, 478 patients meeting eligibility criteria (age 40 to 69 years with recently diagnosed screen or clinically detected diabetes) were individually randomised to receive either intensive treatment (n = 239) or intensive treatment plus a theory-based behaviour change intervention led by a facilitator external to the general practice team (n = 239). Randomisation was central and independent using a partial minimisation procedure to balance stratifiers between treatment arms. Facilitators taught patients skills to facilitate change in and maintenance of key health behaviours, including goal setting, self-monitoring and building habits. Primary outcomes included physical activity energy expenditure (individually calibrated heart rate monitoring and movement sensing), change in objectively measured fruit and vegetable intake (plasma vitamin C), medication adherence (plasma drug levels) and smoking status (plasma cotinine levels) at 1 year. Measurements, data entry and laboratory analysis were conducted with staff unaware of participants' study group allocation. Of 475 participants still alive, 444 (93%; intervention group 95%, comparison group 92%) attended 1-year follow-up. There were no significant differences between groups in physical activity (difference: +1.50 kJ kg(-1) day(-1); 95% CI -1.74, 4.74), plasma vitamin C (difference: -3.84 μmol/l; 95% CI -8.07, 0.38), smoking (OR 1.37; 95% CI 0.77, 2.43) and

  10. Studying Teachers and Schools: Michael Pressley's Legacy and Directions for Future Research

    Science.gov (United States)

    Mohan, Lindsey; Lundeberg, Mary A.; Reffitt, Kelly

    2008-01-01

    Much of Michael Pressley's work during the past decade focused on the nature of highly effective, engaging literacy instruction. Michael Pressley believed that studying effective teachers and schools had the potential to influence more engaging and effective teaching, especially in underresourced schools. First, we describe the grounded…

  11. Markets, Marx, Modernity and Mathematics Education: A Response to Michael Apple.

    Science.gov (United States)

    Gates, Peter

    This paper is a response to Michael Apple's paper, "What Postmodernists Forget: Cultural Capital and Official Knowledge." The paper advocates Michael's identification of the current dangers and processes of the growth of new right ideologies in the development of subjectivity, society, and education. The differences in success in the education…

  12. Reflections on Michael Hardt and Antonio Negri’s Book “Assembly”

    Directory of Open Access Journals (Sweden)

    Christian Fuchs

    2017-10-01

    Full Text Available This contribution presents reflections on Michael Hardt and Antonio Negri’s book “Assembly” (2017, Oxford: Oxford University Press, ISBN 978-0190677961. Keywords: assembly, Michael Hardt, Antonio Negri, multitude, common, entrepreneurship of the multitude, the new Prince, digital capitalism, digital assemblage, neoliberalism, finance

  13. Pasta quality as impacted by the type of flour and starch and the level of egg addition.

    Science.gov (United States)

    Saleh, Mohammed; Al-Ismail, Khalid; Ajo, Radwan

    2017-10-01

    This study investigated the effects of substituting wheat flour with fractions of different starch types and egg levels on pasta quality. First order mixture response surface model was used where the effects of various starch types and egg levels on pasta quality were evaluated. Coefficients of estimation were determined and fractional contribution of wheat, starch type and egg levels were evaluated. Egg levels negatively (p egg level from 33 to 0%. Flow behavior index of treatments solution with various fractions of starch types and egg level ranged from 0.34 to 1.42 and was significantly (p cooked pasta quality including firmness, stickiness, cooking loss, and water uptake, keeping with consumer acceptability through varying starch type and egg level. Results show that flour and starch type and egg level interaction play significant role in pasta blends formulation. Moreover, substitution of wheat flour with acorn, native or modified corn and potato starches fractions, as well as with lupine, rice, tapioca, and stabilized rice bran flours would have significant effects on the physical properties and acceptability of various cereal products. For instance, the use of rice bran in potentially developed products would enhance the consumption of whole grain foods, resulting in improved intake of fiber and other healthy components. © 2016 Wiley Periodicals, Inc.

  14. Effect of Fe and Zr additions on ω phase formation in β-type Ti-Mo alloys

    International Nuclear Information System (INIS)

    Min, X.H.; Emura, S.; Zhang, L.; Tsuzaki, K.

    2008-01-01

    The effect of 1% Fe and/or 5% Zr (mass%) additions on ω phase formation was investigated for the Ti-15Mo alloy by means of X-ray diffraction analysis and hardness testing. Upon water quenching following solution treatment in the β phase region, the athermal ω phase formation could not be observed in all the alloys, regardless of Fe and Zr additions. The lattice parameter of the β phase decreases with Fe addition, while it increases with Zr addition. Solid solution strengthening by Fe and Zr is not recognized for the β phase. The isothermal ω phase formed after aging at 723 K and 773 K for 3.6 ks, which results in a decrease in the lattice parameter of the β phase and an increase in the hardness. The isothermal ω phase formation is suppressed with Fe and/or Zr additions. This is interpreted as the consequence of the increase in the average value of the bond order (Bo) for the Ti-15Mo-5Zr and Ti-15Mo-5Zr-1Fe alloys, and of the decrease in the average value of the metal d-orbital energy level (Md) for the Ti-15Mo-1Fe alloy. In addition, the degree of the suppression of isothermal ω phase can be predicted by the average values of Bo and Md

  15. Effects of Grape Peels Addition on Mixing, Pasting and Fermentation Characteristics of Dough from 480 Wheat Flour Type

    Directory of Open Access Journals (Sweden)

    Silvia MIRONEASA

    2018-05-01

    Full Text Available In this study, white grape peels were incorporated in wheat flour at levels of 3, 5, 7 and 9% (w/w, with different particle sizes (large, L > 500 mm, medium, 200 mm > M < 500 mm and small fractions, S < 200 mm. The effects of the addition of grape peels flour (GPF to wheat flour on the viscoelastic properties of dough and both mixing and proofing behaviour is presented. By GPF addition an increase of water absorption and a decrease of dough stability were recorded, whereas dough development time is remarkable influenced by the particle sizes. Alpha-amylase activity and gelatinization temperature increases by the increased of GPF addition level. The presence of GPF at different levels and particle sizes in dough affected fermentation behaviour of dough with GPF. The whole study shown that grape peels can be used as ingredients in breadmaking in order to improve bread quality.

  16. Effects of the addition of mechanically deboned poultry meat and collagen fibers on quality characteristics of frankfurter-type sausages.

    Science.gov (United States)

    Pereira, Anirene Galvão Tavares; Ramos, Eduardo Mendes; Teixeira, Jacyara Thaís; Cardoso, Giselle Pereira; Ramos, Alcinéia de Lemos Souza; Fontes, Paulo Rogério

    2011-12-01

    The effects of mechanically deboned poultry meat (MDPM) and levels of collagen fibers on comminuted, cooked sausage quality characteristics were investigated using the central composite rotatable design of response surface methodology (RSM). Use of collagen fiber as an additive affected the sausage characteristics, but the effect depended on the amount of the MDPM used. While MDPM additions resulted in higher cooking loss and darker and redder frankfurters, the addition of collagen fibers improved cooking yields and contributed to the lightness of the final product. Higher collagen fiber content was also accompanied by a significant increase in frankfurter hardness regardless of the MDPM content. Use of collagen fibers countered the negative effects of MDPM on sausage quality attributes, especially on cooking yields and final product color. Copyright © 2011 Elsevier Ltd. All rights reserved.

  17. Hexamethoxylated Monocarbonyl Analogues of Curcumin Cause G2/M Cell Cycle Arrest in NCI-H460 Cells via Michael Acceptor-Dependent Redox Intervention.

    Science.gov (United States)

    Li, Yan; Zhang, Li-Ping; Dai, Fang; Yan, Wen-Jing; Wang, Hai-Bo; Tu, Zhi-Shan; Zhou, Bo

    2015-09-09

    Curcumin, derived from the dietary spice turmeric, holds promise for cancer prevention. This prompts much interest in investigating the action mechanisms of curcumin and its analogues. Two symmetrical hexamethoxy-diarylpentadienones (1 and 2) as cucumin analogues were reported to possess significantly enhanced cytotoxicity compared with the parent molecule. However, the detailed mechanisms remain unclear. In this study, compounds 1 and 2 were identified as the G2/M cell cycle arrest agents to mediate the cytotoxicity toward NCI-H460 cells via Michael acceptor-dependent redox intervention. Compared with curcumin, they could more easily induce a burst of reactive oxygen species (ROS) and collapse of the redox buffering system. One possible reason is that they could more effectively target intracellular TrxR to convert this antioxidant enzyme into a ROS promoter. Additionally, they caused up-regulation of p53 and p21 and down-regulation of redox-sensitive Cdc25C along with cyclin B1/Cdk1 in a Michael acceptor- and ROS-dependent fashion. Interestingly, in comparison with compound 2, compound 1 displayed a relatively weak ability to generate ROS but increased cell cycle arrest activity and cytotoxicity probably due to its Michael acceptor-dependent microtubule-destabilizing effect and greater GST-inhibitory activity, as well as its enhanced cellular uptake. This work provides useful information for understanding Michael acceptor-dependent and redox-mediated cytotoxic mechanisms of curcumin and its active analogues.

  18. Michael Field’s “A Dance of Death”

    Directory of Open Access Journals (Sweden)

    LeeAnne Richardson

    2012-03-01

    Full Text Available The 1912 poem "A Dance of Death" by Michael Field (pen name of Katherine Bradley and her niece Edith Cooper depicts Salome in an alternate version of the biblical story: this Salome dances on a frozen river, falls through the ice, and is decapitated on a jagged edge. Nonetheless, her beautiful head continues dancing over the frozen river. This poem is highly unusual, especially in the context of the other poems in the postconversion volume Poems of Adoration, because it questions, rather than submits to, authority. In re-writing a familiar Christian tale, as well as a familiar decadent theme, Field uses the poem to assert the supremacy of their artistic vision, which (despite their ardent Catholicism cannot be subject to any law outside themselves. Like the continually dancing head of Salome, which continues to create beauty even after nature (and perhaps God has struck it down, the poet is subjugate only to her own law and creates without boundaries or restrictions on her art. Bradley and Cooper were acutely aware of their authorial persona (actively taking not only a masculine but also a singular poetic identity, and their mode of reconciling the apparent contradictions of this identity are mirrored in their presentation of Salome in a "Dance of Death."

  19. A Musical Italy: Michael W. Balfe’s Italian Experiences

    Directory of Open Access Journals (Sweden)

    Basil Walsh

    2016-06-01

    Full Text Available The Dublin-born musician, Michael W. Balfe, was a singer, composerand conductor whose brilliant musical career was heavily influenced byformative experiences in Italy. In 1825, Balfe, interested in broadeninghis musical studies first went to Paris where he was introduced to thegreat composers, Luigi Cherubini and Gioachino Rossini, who took apersonal interest in him and his musical talents. On the advice of Rossinihe spent the next few years in Italy studying singing with the famousRossini singer, Filippo Galli, and taking music composition lessonsfrom Ferdinando Paer, in Rome. Later in Milan he studied harmonyand counterpoint with Vincenzo Federici. By 1831, when he was only23 years old, his first three operas had been produced in Palermo, Pavia,and Milan. He returned to London in August 1835, participatingwith the great Lablache, Tamburini, Rubini and Grisi in a concert inVauxhall Gardens. In 1834 he made his debut at La Scala, Milan, singingopposite the renowned mezzo-soprano, Maria Malibran in Rossini’sOtello. He appeared again with Malibran in Venice early in 1835,singing once more in Rossini and Bellini operas. Balfe worked as a singerand composer throughout the Italian peninsula/states during the years,1825-1835 and this article will chart these experiences and demonstratehow the time he spent in Italy and the people he met, influenced hislife and later career as an important and popular European composer.

  20. Effects of phosphorus addition on soil microbial biomass and community composition in three forest types in tropical China

    DEFF Research Database (Denmark)

    Liu, Lei; Gundersen, Per; Zhang, Tao

    2012-01-01

    Elevated nitrogen (N) deposition in humid tropical regions may aggravate phosphorus (P) deficiency in forest on old weathered soil found in these regions. From January 2007 to August 2009, we studied the responses of soil microbial biomass and community composition to P addition (in two monthly...

  1. Synthesis of substituted gamma-lactams through petasis-type addition of boronic acids to N-acyliminium lons

    DEFF Research Database (Denmark)

    Wu, Peng; Clausen, Mads Hartvig; Nielsen, Thomas Eiland

    2014-01-01

    Substituted g -lactams are important heterocyclic motifs found in various biologically active compounds and marketed drugs, such as glimepiride, doxapram, and levetiracetam. Among available m ethods for the synthesis of substituted g -lactams, the addition of nucleophiles to N -acyliminium ions...

  2. Influence of silver additions to type 316 stainless steels on bacterial inhibition, mechanical properties, and corrosion resistance

    DEFF Research Database (Denmark)

    Chiang, Wen-Chi; Tseng, I-Sheng; Møller, Per

    2010-01-01

    Bacterial contamination is a major concern in many areas. In this study, silver was added to type 316 stainless steels in order to obtain an expected bacteria inhibiting property to reduce the occurrence of bacterial contamination. Silver-bearing 316 stainless steels were prepared by vacuum melting...... in areas where hygiene is a major requirement. The possible mechanisms of silver dissolution from the surfaces of silver-bearing 316 stainless steels were also discussed in this report....

  3. New eco-friendly animal bone meal catalysts for preparation of chalcones and aza-Michael adducts

    Directory of Open Access Journals (Sweden)

    Riadi Yassine

    2012-06-01

    Full Text Available Abstract Two efficient reactions were successfully carried out using Animal Bone Meal (ABM and potassium fluoride or sodium nitrate doped ABMs as new heterogeneous catalysts under very mild conditions. After preparation and characterization of the catalysts, we first report their use in a simple and convenient synthesis of various chalcones by Claisen–Schmidt condensation and then in an aza-Michael addition involving several synthesized chalcones with aromatic amines. All the reactions were carried out at room temperature in methanol; the chalcone synthesis was also achieved in water environment under microwave irradiation. Doping ABM enhances the rate and yield at each reaction. Catalytic activities are discussed and the ability to re-use the ABM is demonstrated. Results For Claisen–Schmidt the use of ABM alone, yields never exceeded 17%. In each entry, KF/ABM and NaNO3/ABM (79-97% gave higher yields than using ABM alone under thermic condition. Also the reaction proceeded under microwave irradiation in good yields (72-94% for KF/ABM and 81-97% for NaNO3/ABM and high purity. For aza-Michael addition the use of ABM doped with KF or NaNO3 increased the catalytic activity remarkably. The very high yields could be noted (84-95% for KF/ABM and 81-94% for NaNO3/ABM. Conclusion The present method is an efficient and selective procedure for the synthesis of chalcones an aza-Michael adducts. The ABM and doped ABMs are a new, inexpensive and attractive solid supports which can contribute to the development of catalytic processes and reduced environmental problems.

  4. 75 FR 62635 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Science.gov (United States)

    2010-10-12

    ... Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program) Activity: Comment Request... determine patients' satisfaction with services provided by or through the Michael E. DeBakey Home Care...: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form 10-0476. OMB Control Number...

  5. The effects of additional black carbon on Arctic sea ice surface albedo: variation with sea ice type and snow cover

    OpenAIRE

    A. A. Marks; M. D. King

    2013-01-01

    Black carbon in sea ice will decrease sea ice surface albedo through increased absorption of incident solar radiation, exacerbating sea ice melting. Previous literature has reported different albedo responses to additions of black carbon in sea ice and has not considered how a snow cover may mitigate the effect of black carbon in sea ice. Sea ice is predominately snow covered. Visible light absorption and light scattering coefficients are calculated for a typical first year and multi-y...

  6. Increased Oxidation as an Additional Mechanism Underlying Reduced Clot Permeability and Impaired Fibrinolysis in Type 2 Diabetes

    Directory of Open Access Journals (Sweden)

    Anna Lados-Krupa

    2015-01-01

    Full Text Available Aims. We sought to investigate whether enhanced oxidation contributes to unfavorable fibrin clot properties in patients with diabetes. Methods. We assessed plasma fibrin clot permeation (Ks, a measure of the pore size in fibrin networks and clot lysis time induced by recombinant tissue plasminogen activator (CLT in 163 consecutive type 2 diabetic patients (92 men and 71 women aged 65 ± 8.8 years with a mean glycated hemoglobin (HbA1c of 6.8%. We also measured oxidative stress markers, including nitrotyrosine, the soluble form of receptor for advanced glycation end products (sRAGE, 8-iso-prostaglandin F2α (8-iso-PGF2α, oxidized low-density lipoprotein (oxLDL, and advanced glycation end products (AGE. Results. There were inverse correlations between Ks and nitrotyrosine, sRAGE, 8-iso-PGF2α, and oxLDL. CLT showed a positive correlation with oxLDL and nitrotyrosine but not with other oxidation markers. All these associations remained significant for Ks after adjustment for fibrinogen, disease duration, and HbA1c (all P<0.05, while oxLDL was the only independent predictor of CLT. Conclusions. Our study shows that enhanced oxidative stress adversely affects plasma fibrin clot properties in type 2 diabetic patients, regardless of disease duration and glycemia control.

  7. The Effect of MoO42- Addition on the Intergranular Corrosion Behavior of Sensitized type 304 Stainless Steel

    International Nuclear Information System (INIS)

    Lee, Kee Pyo; Kim, Kwan Hyu

    1988-01-01

    This experiment is aimed at the investigation of the effect of MoO 4 2- added to the electrolyte on the corrosion behavior of sensitized 304 stainless steel. The specimens of 304 stainless steel were sensitized for 1 hour at 800 .deg. C, and also for 1 hour at 800 .deg. C followed by 600 .deg. C for 2 hours. Polarization curves of the specimens were obtained in 1N H 2 SO 4 + 0.2N NCl (with or without 0.001M MoO 4 2- ) and in 1N H 2 SO 4 + 0.01N KSCN (with or without 0.001M MoO 4 2- )solutions. All specimens after corrosion test were subjected to microstructural analysis by using an optical microscope. The susceptibility of 304 stainless steel to the intergranular corrosion was decreased by the addition of MoO 4 2- to the electrolyte. It is suggested that the MoO 4 2- in the electrolyte leads to the easy formation of a passive film on the stainless steel substrate. It was confirmed that the area of intergranular attack of stainless steel was decreased by the addition of MoO 4 2- to the electrolyte

  8. Screening for type 2 diabetes and population mortality over 10 years (ADDITION-Cambridge): a cluster-randomised controlled trial.

    Science.gov (United States)

    Simmons, Rebecca K; Echouffo-Tcheugui, Justin B; Sharp, Stephen J; Sargeant, Lincoln A; Williams, Kate M; Prevost, A Toby; Kinmonth, Ann Louise; Wareham, Nicholas J; Griffin, Simon J

    2012-11-17

    The increasing prevalence of type 2 diabetes poses a major public health challenge. Population-based screening and early treatment for type 2 diabetes could reduce this growing burden. However, uncertainty persists around the benefits of screening for type 2 diabetes. We assessed the effect of a population-based stepwise screening programme on mortality. In a pragmatic parallel group, cluster-randomised trial, 33 general practices in eastern England were randomly assigned by the method of minimisation in an unbalanced design to: screening followed by intensive multifactorial treatment for people diagnosed with diabetes (n=15); screening plus routine care of diabetes according to national guidelines (n=13); and a no-screening control group (n=5). The study population consisted of 20,184 individuals aged 40-69 years (mean 58 years), at high risk of prevalent undiagnosed diabetes, on the basis of a previously validated risk score. In screening practices, individuals were invited to a stepwise programme including random capillary blood glucose and glycated haemoglobin (HbA(1c)) tests, a fasting capillary blood glucose test, and a confirmatory oral glucose tolerance test. The primary outcome was all-cause mortality. All participants were flagged for mortality surveillance by the England and Wales Office of National Statistics. Analysis was by intention-to-screen and compared all-cause mortality rates between screening and control groups. This study is registered, number ISRCTN86769081. Of 16,047 high-risk individuals in screening practices, 15,089 (94%) were invited for screening during 2001-06, 11,737 (73%) attended, and 466 (3%) were diagnosed with diabetes. 4137 control individuals were followed up. During 184,057 person-years of follow up (median duration 9·6 years [IQR 8·9-9·9]), there were 1532 deaths in the screening practices and 377 in control practices (mortality hazard ratio [HR] 1·06, 95% CI 0·90-1·25). We noted no significant reduction in

  9. Effect of Cereal Type and Enzyme Addition on Performance, Pancreatic Enzyme Activity, Intestinal Microflora and Gut Morphology of Broilers

    Directory of Open Access Journals (Sweden)

    Kalantar M

    2016-06-01

    Full Text Available The effects of grain and carbohydrase enzyme supplementation were investigated on digestive physiology of chickens. A total of 625 one-day-old chicks (Ross 308 were randomly assigned to five treatments in a completely randomized design. Treatments included two different types of grains (wheat, and barley with or without a multi-carbohydrase supplement. A corn-based diet was also considered to serve as a control. Feeding barley-based diet with multi-carbohydrase led to higher feed intake (P < 0.01 than those fed corn- and wheat-based diets. Birds fed on barley and wheat diets had lower weight gain despite a higher feed conversion ratio (P < 0.01. Total count and number of different type of bacteria including Gram-negative, E. coli, and Clostridia increased after feeding wheat and barley but the number of Lactobacilli and Bifidobacteria decreased (P < 0.01. Feeding barley and wheat diets reduced villus height in different parts of the small intestine when compared to those fed on a corn diet. However, enzyme supplementation of barley and wheat diets improved weight gain and feed conversion ratio and resulted in reduced number of E. coli and Clostridia and increased number of Lactobacilli and Bifidobacteria, and also restored the negative effects on intestinal villi height (P < 0.01. The activities of pancreatic α-amylase and lipase were (P < 0.01 increased in chickens fed wheat and barley diets when compared to the control fed on a corn diet. Enzyme supplementation reduced the activities of pancreatic α-amylase and lipase (P < 0.01. In conclusion, various dietary non-starch polysaccharides without enzyme supplementation have an adverse effect on digesta viscosity, ileal microflora, villi morphology, and pancreatic enzyme activity.

  10. Are lifestyle changes achieved after participation in a screening programme for Type 2 diabetes? The ADDITION Study, Denmark

    DEFF Research Database (Denmark)

    Mai, K S; Sandbaek, A; Borch-Johnsen, K

    2007-01-01

    . The screening comprised two main steps: identification of high-risk individuals by a mailed risk score questionnaire, and subsequent testing of high-risk individuals by their general practitioner. Questionnaires on physical exercise [International Physical Activity Questionnaire (IPAQ), short form], smoking...... habits and alcohol consumption were mailed to the target population 1 month prior to the offer of screening, and at 12 months' follow-up. At follow-up, additional questions regarding perceived changes in dietary habits, smoking, alcohol consumption and exercise were included. Three pairs of comparison...... groups were analysed. RESULTS: One year after screening, smokers who underwent further testing reduced smoking by one daily cigarette more than people at low risk of diabetes. The rate of smokers was not reduced, and the result was not confirmed by data regarding perceived change. Alcohol intake...

  11. LUT REVEALS AN ALGOL-TYPE ECLIPSING BINARY WITH THREE ADDITIONAL STELLAR COMPANIONS IN A MULTIPLE SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, L.-Y.; Zhou, X.; Qian, S.-B.; Li, L.-J.; Liao, W.-P.; Tian, X.-M.; Wang, Z.-H. [Yunnan Observatories, Chinese Academy of Sciences (CAS), P.O. Box 110, 650011 Kunming (China); Hu, J.-Y., E-mail: zhuly@ynao.ac.cn [National Astronomical Observatories, Chinese Academy of Sciences, 100012 Beijing (China)

    2016-04-15

    A complete light curve of the neglected eclipsing binary Algol V548 Cygni in the UV band was obtained with the Lunar-based Ultraviolet Telescope in 2014 May. Photometric solutions are obtained using the Wilson–Devinney method. It is found that solutions with and without third light are quite different. The mass ratio without third light is determined to be q = 0.307, while that derived with third light is q = 0.606. It is shown that V548 Cygni is a semi-detached binary where the secondary component is filling the critical Roche lobe. An analysis of all available eclipse times suggests that there are three cyclic variations in the O–C diagram that are interpreted by the light travel-time effect via the presence of three additional stellar companions. This is in agreement with the presence of a large quantity of third light in the system. The masses of these companions are estimated as m sin i′ ∼ 1.09, 0.20, and 0.52 M{sub ⊙}. They are orbiting the central binary with orbital periods of about 5.5, 23.3, and 69.9 years, i.e., in 1:4:12 resonance orbit. Their orbital separations are about 4.5, 13.2, and 26.4 au, respectively. Our photometric solutions suggest that they contribute about 32.4% to the total light of the multiple system. No obvious long-term changes in the orbital period were found, indicating that the contributions of the mass transfer and the mass loss due to magnetic braking to the period variations are comparable. The detection of three possible additional stellar components orbiting a typical Algol in a multiple system make V548 Cygni a very interesting binary to study in the future.

  12. Late Quaternary vegetation and climate history of the central Bering land bridge from St. Michael Island, western Alaska

    Science.gov (United States)

    Ager, T.A.

    2003-01-01

    Pollen analysis of a sediment core from Zagoskin Lake on St. Michael Island, northeast Bering Sea, provides a history of vegetation and climate for the central Bering land bridge and adjacent western Alaska for the past ???30,000 14C yr B.P. During the late middle Wisconsin interstadial (???30,000-26,000 14C yr B.P.) vegetation was dominated by graminoid-herb tundra with willows (Salix) and minor dwarf birch (Betula nana) and Ericales. During the late Wisconsin glacial interval (26,000-15,000 14C yr B.P.) vegetation was graminoid-herb tundra with willows, but with fewer dwarf birch and Ericales, and more herb types associated with dry habitats and disturbed soils. Grasses (Poaceae) dominated during the peak of this glacial interval. Graminoid-herb tundra suggests that central Beringia had a cold, arid climate from ???30,000 to 15,000 14C yr B.P. Between 15,000 and 13,000 14C yr B.P., birch shrub-Ericales-sedge-moss tundra began to spread rapidly across the land bridge and Alaska. This major vegetation change suggests moister, warmer summer climates and deeper winter snows. A brief invasion of Populus (poplar, aspen) occurred ca. 11,000-9500 14C yr B.P., overlapping with the Younger Dryas interval of dry, cooler(?) climate. During the latest Wisconsin to middle Holocene the Bering land bridge was flooded by rising seas. Alder shrubs (Alnus crispa) colonized the St. Michael Island area ca. 8000 14C yr B.P. Boreal forests dominated by spruce (Picea) spread from interior Alaska into the eastern Norton Sound area in middle Holocene time, but have not spread as far west as St. Michael Island. ?? 2003 University of Washington. Published by Elsevier Inc. All rights reserved.

  13. Co-ingestion of a protein hydrolysate with or without additional leucine effectively reduces postprandial blood glucose excursions in type 2 diabetic men

    NARCIS (Netherlands)

    Manders, R.J.; Koopman, R.; Sluijsmans, W.E.; Berg, R. van den; Verbeek, K.; Saris, W.H.; Wagenmakers, A.J.; Loon, L.J. van

    2006-01-01

    This study examined postprandial plasma insulin and glucose responses after co-ingestion of an insulinotropic protein (Pro) hydrolysate with and without additional free leucine with a single bolus of carbohydrate (Cho). Male patients with long-standing Type 2 diabetes (n = 10) and healthy controls

  14. Alpha-tocopherol and β-carotene in legume-grass mixtures as influenced by wilting, ensiling and type of silage additive

    DEFF Research Database (Denmark)

    Lindqvist, H; Nadeau, E; Jensen, Søren Krogh

    2012-01-01

    Effects of wilting, ensiling and type of additive on α-tocopherol and β-carotene contents in legume–grass mixtures were examined. Swards of birdsfoot trefoil + timothy (Bft + Ti), red clover + timothy (Rc + Ti) and red clover + meadow fescue (Rc + Mf) were harvested as a first regrowth in August...

  15. 77 FR 56138 - World Trade Center Health Program; Addition of Certain Types of Cancer to the List of WTC-Related...

    Science.gov (United States)

    2012-09-12

    ... lymphoid tissues (including, but not limited to, lymphoma, leukemia, and myeloma) [ssquf] Childhood cancers... and autonomic nervous system [C47) and malignant neoplasm of other connective and soft tissue [C49... 0920-AA49 World Trade Center Health Program; Addition of Certain Types of Cancer to the List of WTC...

  16. Additional approaches to DNA typing of skeletal remains: the search for "missing" persons killed during the last dictatorship in Argentina.

    Science.gov (United States)

    Corach, D; Sala, A; Penacino, G; Iannucci, N; Bernardi, P; Doretti, M; Fondebrider, L; Ginarte, A; Inchaurregui, A; Somigliana, C; Turner, S; Hagelberg, E

    1997-08-01

    DNA typing techniques are among the most advanced tools for human identification and can contribute to the identification of poorly preserved skeletal remains. Ten thousand people are thought to have been killed during the last dictatorship in Argentina (1976-1983) and there are few official records on the identity of the victims or the location of burials. A mass grave containing 340 skeletons was excavated using archeological methods. A small number of individuals was identified by traditional forensic methods and one family group by mitochondrial DNA (mtDNA) analysis. Due to the lack of antemortem physical information on many of the victims, the application of molecular methods is imperative to speed up the identification process. We have tested two molecular screening methods, Y chromosome-specific short tandem repeats (DYS19, DYS385, DYS389 I, DYS389 II, DYS390, DYS391, DYS392, DYS393) and amplification of autosomal microsatellites using nested primers. These methods can complement solely matrilineal mtDNA sequence data in the identification of "missing" persons.

  17. The death of ink: the value of typing skills as an addition to the medical school curriculum

    Directory of Open Access Journals (Sweden)

    Miah S

    2017-10-01

    Full Text Available Saiful Miah,1 Hashim U Ahmed21Department of Urology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, 2Imperial College London, London, UKWe read with great interest the article by Malik on the importance of writing skills, which has been highlighted as one of the four  competencies that all medical students should possess as future doctors.1 Malik’s article also stated that “first and foremost”writing in a legible manner is imperative for good clinical practice.1While we wholeheartedly agree with these statements, one potentially overlooked skill that we predict will overtake the requirement of legible writing skills within a generation of doctors is typing proficiency. Decades of investment and development of electronic health records (EHRs have resulted in a greater implementation of this tool globally.2 EHRs have been shown through use of reminders, electronic order sets and other means to improve reliability of performance of many basic tasks in acute, preventive and chronic medical care.2View the original paper by Malik. 

  18. Theory and practice in action: the contributions of Michael Perkins to clinical linguistics.

    Science.gov (United States)

    Damico, Jack S; Lynch, Karen E

    2013-01-01

    This article reviews the scholarly contributions of Michael R. Perkins in the discipline of clinical linguistics and provides some indication of the reasons that he has been so successful. Three primary attributes were described through an analysis of his publications.

  19. Tõsine fotoelamus Dubrovnikus / Wade Goddard, Heidi Levine, Michael Robinson Chaver ; interv. Ahto Külvet

    Index Scriptorium Estoniae

    Goddard, Wade

    2007-01-01

    Dubrovniku vanalinnas asub Sõjafotokeskus. Intervjuu keskuse asutaja, kanadalasest fotograafi Wade Goddardi ja kahe seal augustis avatud näitusel osalenud fotograafi Heidi Levine'i ja Michael Robinson Chavez'iga. Sõjafotograafi tööst

  20. Joseph and Michael Haydn in the Bohemian music archives. An anniversary tribute

    Czech Academy of Sciences Publication Activity Database

    Freemanová, Michaela

    2012-01-01

    Roč. 20, č. 1 (2012), s. 117-126. ISBN 978-3-486-58949-8. ISSN 1865-5696 Institutional support: RVO:68378076 Keywords : Joseph Haydn * Michael Haydn * music archives Subject RIV: AL - Art, Architecture, Cultural Heritage

  1. Eesti disain on kõva, ent see tuleb moondada ekspordiks / Michael Thomson ; interv. Urmas Oja

    Index Scriptorium Estoniae

    Thomson, Michael

    2008-01-01

    Euroopa Disainiassotsiatsioonide Liidu presidendi ja Tallinnas toimunud festivali Disainiöö Eesti disainiauhinna Bruno žürii juhi Michael Thomsoni arvamus eesti disainist ning disainipoliitika vajalikkusest Eestis. Auhinnasaajate nimekiri

  2. Reports of the working groups / Eino Tamm, Sahlin Michael, Valve Kirsipuu...[jt.

    Index Scriptorium Estoniae

    1999-01-01

    Töögruppide "EU enlargement and relevant institutional reforms" (juhatajad Eino Tamm, Michael Sahlin) ja "Maintaining of competitiveness of Estonia and other candidate countries" (juhatajad Valve Kirsipuu, Terry Calbom) tööst. Autor: Reformierakond

  3. Michael Bloomberg ähvardab USA valimised "ära rikkuda" / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2008-01-01

    New Yorgi praegune linnapea Michael Bloomberg võib kolmanda kandidaadina sekkuda presidendikandidaatide valimiskampaaniasse, probleem on aga tema vähene tuntus. Lisa: Seni on riigipeakoha jaganud kaks suurparteid

  4. Prints Charles ja prints Michael külastasid Tallinna kirikuid / Allan Tammiku

    Index Scriptorium Estoniae

    Tammiku, Allan

    2001-01-01

    Prints Charles külastas 6. novembril Eesti-visiidi ajal Tallinna toomkirikut ja Pühavaimu kirikut, prints Michael viibis Tallinnas 11. novembril eravisiidil, ta külastas toomkirikut, Niguliste ja Pühavaimu kirikut

  5. Effects of additions on AB{sub 5}-type hydrogen storage alloy in MH-Ni battery application

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xiangdong; Feng, Hongwei; Tian, Xiao; Chi, Bo; Yan, Shufang [School of Material Science and Engineering, Inner Mongolia University of Technology, Hohhot 010051 (China); Xu, Jin [Zhanjiang University of Radio and Television, Zhanjiang 524003 (China)

    2009-09-15

    The AB{sub 5}-type hydrogen storage alloy of Mm{sub 0.3}Ml{sub 0.7}Ni{sub 3.55}Co{sub 0.75}Mn{sub 0.4}Al{sub 0.3} were synthesized and mixed with PVA (Polyvinyl Alcohol) or different percentage Ni powder as the test samples. The cycle stabilities of the composites were tested in 6 M KOH electrolyte through electrochemical method. The results indicated that all the samples with Ni powder have better cycle stabilities and flatter discharge voltage platform. The sample of Mm{sub 0.3}Ml{sub 0.7}Ni{sub 3.55}Co{sub 0.7}5Mn{sub 0.4}Al{sub 0.3} + 200 wt.% Ni has the highest capacity conservation rate of 80.5% and the longest discharge time of 5.2 h. The SEM images show that the particle diameters of the alloy decreased by 2 {mu}m and the surface smoothed without sharp edges after adding Ni powder. It can be presumed that adding Ni can improve the cycle stability of the alloy of Mm{sub 0.3}Ml{sub 0.7}Ni{sub 3.55}Co{sub 0.7}5Mn{sub 0.4}Al{sub 0.3} in the alkaline electrolyte and enhance the reaction rate in the charge/discharge cycles. (author)

  6. Chinese Middle Classes: Taiwan, Hong Kong, Macao and China. Edited by Hsin-Huang Michael Hsiao

    DEFF Research Database (Denmark)

    Brødsgaard, Kjeld Erik

    2018-01-01

    Book review of: Chinese Middle Classes:Taiwan, Hong Kong, Macao and China. Edited by Hsin-Huang Michael Hsiao. Abingdon: Routledge, 2014. Pp. 268. ISBN 10: 1138120847; ISBN 13: 978-1138120846......Book review of: Chinese Middle Classes:Taiwan, Hong Kong, Macao and China. Edited by Hsin-Huang Michael Hsiao. Abingdon: Routledge, 2014. Pp. 268. ISBN 10: 1138120847; ISBN 13: 978-1138120846...

  7. Antidiabetic effects of Artemisia sphaerocephala Krasch. gum, a novel food additive in China, on streptozotocin-induced type 2 diabetic rats.

    Science.gov (United States)

    Xing, Xiao-Hui; Zhang, Zheng-Mao; Hu, Xin-Zhong; Wu, Rui-Qin; Xu, Chao

    2009-09-25

    Since ancient times, practicians of traditional Chinese medicine have discovered that Artemisia sphaerocephala Krasch. (Asteraceae) seed powder was useful for the treatment of diabetes. Artemisia sphaerocephala Krasch. gum (ASK gum), which is extracted from seed powder of the plant, is a novel food additive favored by the food industry in China. The objective of this study was to determine the antidiabetic function of ASK gum on type 2 diabetes. Type 2 diabetic rat model was induced with high fat diet and low dose of streptozotocin (STZ). The effects of ASK gum on hyperglycemia, hyperlipemia, insulin resistance, and liver fat accumulation in type 2 diabetic rats were evaluated. The results were compared to those of normal rats and diabetic rats treated with metformin. The addition of ASK gum to the rats' food supply significantly lowered fasting blood glucose, glycated serum protein, serum cholesterol, and serum triglyceride in type 2 diabetic rats, and significantly elevated liver glucokinase, liver glycogen, and serum high density protein cholesterol in the diabetic rats. ASK gum significantly reduced insulin resistance and liver fat accumulation of type 2 diabetes. Artemisia sphaerocephala Krasch. gum can alleviate hyperglycemia, hyperlipemia and insulin resistance of type 2 diabetes.

  8. Operational Cybersecurity Risks and Their Effect on Adoption of Additive Manufacturing in the Naval Domain

    Science.gov (United States)

    2017-12-01

    CYBERSECURITY RISKS AND THEIR EFFECT ON ADOPTION OF ADDITIVE MANUFACTURING IN THE NAVAL DOMAIN by Michael D. Grimshaw December 2017 Thesis...OF ADDITIVE MANUFACTURING IN THE NAVAL DOMAIN 5. FUNDING NUMBERS 6. AUTHOR(S) Michael D. Grimshaw 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES...DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words) Additive manufacturing (AM) has been proven to provide multiple benefits over traditional

  9. Optimized thermoelectric performance of the n-type half-Heusler material TiNiSn by substitution and addition of Mn

    Directory of Open Access Journals (Sweden)

    Enkhtaivan Lkhagvasuren

    2017-04-01

    Full Text Available Alloys based on the half-Heusler compound TiNiSn with the addition of Mn or with a substitution of Ti by Mn are investigated as high-temperature thermoelectric materials. In both materials an intrinsic phase separation is observed, similar to TiNiSn where Ti has been partially substituted by Hf, with increasing Mn concentration the phase separation drastically reduces the lattice thermal conductivity while the power factor is increased. The thermoelectric performance of the n-type conducting alloy can be optimized both by substitution of Ti by Mn as well as the addition of Mn.

  10. Influence of CaCO3 and SiO2 additives on magnetic properties of M-type Sr ferrites

    Science.gov (United States)

    Huang, Ching-Chien; Jiang, Ai-Hua; Hung, Yung-Hsiung; Liou, Ching-Hsuan; Wang, Yi-Chen; Lee, Chi-Ping; Hung, Tong-Yin; Shaw, Chun-Chung; Kuo, Ming-Feng; Cheng, Chun-Hu

    2018-04-01

    An experiment was carried out to investigate the influence of CaCO3 and SiO2 additives on the magnetic and physical properties of M-type Sr ferrites by changing experimental parameters such as the additive composition and Ca/Si ratio. Specimens were prepared by conventional ceramic techniques. It was found that the magnetic properties (Br = 4.42 kG, iHc = 3.32 kOe and (BH)max = 4.863 MGOe) were considerably improved upon adding CaCO3 = 1.1% and SiO2 = 0.4 wt% together with Co3O4, and the mechanical properties thereof were acceptable for motor applications. It was revealed that CaCO3 and SiO2 additives led to an upswing in the magnetic properties via the enhancement of uniform grain growth, particle alignment, and the densification of Sr ferrite.

  11. Direct enantioselective conjugate addition of carboxylic acids with chiral lithium amides as traceless auxiliaries.

    Science.gov (United States)

    Lu, Ping; Jackson, Jeffrey J; Eickhoff, John A; Zakarian, Armen

    2015-01-21

    Michael addition is a premier synthetic method for carbon-carbon and carbon-heteroatom bond formation. Using chiral dilithium amides as traceless auxiliaries, we report the direct enantioselective Michael addition of carboxylic acids. A free carboxyl group in the product provides versatility for further functionalization, and the chiral reagent can be readily recovered by extraction with aqueous acid. The method has been applied in the enantioselective total synthesis of the purported structure of pulveraven B.

  12. Direct Enantioselective Conjugate Addition of Carboxylic Acids with Chiral Lithium Amides as Traceless Auxiliaries

    Science.gov (United States)

    2016-01-01

    Michael addition is a premier synthetic method for carbon–carbon and carbon–heteroatom bond formation. Using chiral dilithium amides as traceless auxiliaries, we report the direct enantioselective Michael addition of carboxylic acids. A free carboxyl group in the product provides versatility for further functionalization, and the chiral reagent can be readily recovered by extraction with aqueous acid. The method has been applied in the enantioselective total synthesis of the purported structure of pulveraven B. PMID:25562717

  13. Effects of the addition of blood plasma proteins on physico-chemical properties of emulsion-type pork sausage during cold storage.

    Science.gov (United States)

    Kim, Sungho; Jin, Sangkeun; Choi, Jungseok

    2017-10-01

    Most slaughter blood is discarded, resulting in problems related to costs for wastewater disposal and environmental pollution. However, animal blood contains various proteins such as albumin, globulin and globin and can be used as a natural emulsifier, stabiliser and colour additive. Thus, this study was carried out to investigate the effect of blood plasma proteins on the physico-chemical properties of emulsion-type pork sausages stored at 4°C over 5 weeks. The emulsion-type pork sausages with plasma powders had higher pH than the other treatments during week 5, and higher shear force than the control (P binder for the production of excellent meat products compared to other binders. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  14. Mother's love' for bacterial babies: the commitment of Audrey Michael, Mition Yoannes and Tilda Orami to medical research.

    Science.gov (United States)

    Gibbs, Tammy; Vilakiva, Geraldine

    2013-01-01

    Audrey Michael, Mition Yoannes and Tilda Orami are long-term health researchers at the Papua New Guinea Institute of Medical Research (PNGIMR). Face-to-face interviews were conducted with all three women for the purpose of profiling women who are leaders in health and medicine in Papua New Guinea. They were asked questions about their early life and childhood, education, work life and training, and mentors who have supported their career path and leadership role. Audrey, Mition and Tilda have all made significant contributions to the PNGIMR and to the health of the people of PNG. In particular, all three have been part of pneumococcal conjugate vaccine (PCV) studies--looking at the safety, immunogenicity and priming for immunological memory of a 7-valent PCV and investigating the safety and immune responses to two different, recently licensed types of PCV, a 13-valent and a 10-valent vaccine.

  15. The effects of additional black carbon on the albedo of Arctic sea ice: variation with sea ice type and snow cover

    OpenAIRE

    A. A. Marks; M. D. King

    2013-01-01

    The response of the albedo of bare sea ice and snow-covered sea ice to the addition of black carbon is calculated. Visible light absorption and light-scattering cross-sections are derived for a typical first-year and multi-year sea ice with both "dry" and "wet" snow types. The cross-sections are derived using data from a 1970s field study that recorded both reflectivity and light penetration in Arctic sea ice and snow overlying sea ice. The variation of absorption cross-section ov...

  16. Associations between Ultrasound Measures of Abdominal Fat Distribution and Indices of Glucose Metabolism in a Population at High Risk of Type 2 Diabetes: The ADDITION-PRO Study

    DEFF Research Database (Denmark)

    Philipsen, Annelotte; Jørgensen, Marit E; Vistisen, Dorte

    2015-01-01

    metabolism in a population at high risk of type 2 diabetes. METHODS: A cross-sectional analysis of 1342 participants of the ADDITION-PRO study. We measured visceral adipose tissue and subcutaneous adipose tissue with ultrasonography, anthropometrics and body fat percentage by bioelectrical impedance. Indices...... standard deviation difference in BMI, visceral adipose tissue, waist circumference, waist/height ratio and body fat percentage corresponded approximately to 0.2mmol/l higher fasting glucose, 0.7mmol/l higher 2-hr glucose, 0.06-0.1% higher HbA1c, 30 % lower HOMA index of insulin sensitivity, 20% lower Gutt...

  17. Dr. O.S Michael Department of Pharmacology and Therapeutics ...

    African Journals Online (AJOL)

    its machinery just as much as he has in the anatomical laboratory, and ...to combine ... nurses, and other health professionals, in addition to delivering medical care to patients. ... better understanding of human physiology and was the earliest ...

  18. Michael Goodsite gæsteprofessor på Thunderbird School of Global Management

    DEFF Research Database (Denmark)

    Pedersen, Jens Christian

    2010-01-01

    Professor Michael Goodsite er blevet udnævnt til "Visiting Professor of Global Processes and Senior Research Fellow in Climate Strategy" ved Thunderbird School of Global Management, som har verdens højst rangerede MBA uddannelse inden for international handel.......Professor Michael Goodsite er blevet udnævnt til "Visiting Professor of Global Processes and Senior Research Fellow in Climate Strategy" ved Thunderbird School of Global Management, som har verdens højst rangerede MBA uddannelse inden for international handel....

  19. Solid State Ionics: from Michael Faraday to green energy-the European dimension.

    Science.gov (United States)

    Funke, Klaus

    2013-08-01

    Solid State Ionics has its roots essentially in Europe. First foundations were laid by Michael Faraday who discovered the solid electrolytes Ag 2 S and PbF 2 and coined terms such as cation and anion , electrode and electrolyte . In the 19th and early 20th centuries, the main lines of development toward Solid State Ionics, pursued in Europe, concerned the linear laws of transport, structural analysis, disorder and entropy and the electrochemical storage and conversion of energy. Fundamental contributions were then made by Walther Nernst, who derived the Nernst equation and detected ionic conduction in heterovalently doped zirconia, which he utilized in his Nernst lamp. Another big step forward was the discovery of the extraordinary properties of alpha silver iodide in 1914. In the late 1920s and early 1930s, the concept of point defects was established by Yakov Il'ich Frenkel, Walter Schottky and Carl Wagner, including the development of point-defect thermodynamics by Schottky and Wagner. In terms of point defects, ionic (and electronic) transport in ionic crystals became easy to visualize. In an 'evolving scheme of materials science', point disorder precedes structural disorder, as displayed by the AgI-type solid electrolytes (and other ionic crystals), by ion-conducting glasses, polymer electrolytes and nano-composites. During the last few decades, much progress has been made in finding and investigating novel solid electrolytes and in using them for the preservation of our environment, in particular in advanced solid state battery systems, fuel cells and sensors. Since 1972, international conferences have been held in the field of Solid State Ionics, and the International Society for Solid State Ionics was founded at one of them, held at Garmisch-Partenkirchen, Germany, in 1987.

  20. Solid State Ionics: from Michael Faraday to green energy—the European dimension

    Science.gov (United States)

    Funke, Klaus

    2013-01-01

    Solid State Ionics has its roots essentially in Europe. First foundations were laid by Michael Faraday who discovered the solid electrolytes Ag2S and PbF2 and coined terms such as cation and anion, electrode and electrolyte. In the 19th and early 20th centuries, the main lines of development toward Solid State Ionics, pursued in Europe, concerned the linear laws of transport, structural analysis, disorder and entropy and the electrochemical storage and conversion of energy. Fundamental contributions were then made by Walther Nernst, who derived the Nernst equation and detected ionic conduction in heterovalently doped zirconia, which he utilized in his Nernst lamp. Another big step forward was the discovery of the extraordinary properties of alpha silver iodide in 1914. In the late 1920s and early 1930s, the concept of point defects was established by Yakov Il'ich Frenkel, Walter Schottky and Carl Wagner, including the development of point-defect thermodynamics by Schottky and Wagner. In terms of point defects, ionic (and electronic) transport in ionic crystals became easy to visualize. In an ‘evolving scheme of materials science’, point disorder precedes structural disorder, as displayed by the AgI-type solid electrolytes (and other ionic crystals), by ion-conducting glasses, polymer electrolytes and nano-composites. During the last few decades, much progress has been made in finding and investigating novel solid electrolytes and in using them for the preservation of our environment, in particular in advanced solid state battery systems, fuel cells and sensors. Since 1972, international conferences have been held in the field of Solid State Ionics, and the International Society for Solid State Ionics was founded at one of them, held at Garmisch-Partenkirchen, Germany, in 1987. PMID:27877585

  1. Solid State Ionics: from Michael Faraday to green energy—the European dimension

    Directory of Open Access Journals (Sweden)

    Klaus Funke

    2013-01-01

    Full Text Available Solid State Ionics has its roots essentially in Europe. First foundations were laid by Michael Faraday who discovered the solid electrolytes Ag2S and PbF2 and coined terms such as cation and anion, electrode and electrolyte. In the 19th and early 20th centuries, the main lines of development toward Solid State Ionics, pursued in Europe, concerned the linear laws of transport, structural analysis, disorder and entropy and the electrochemical storage and conversion of energy. Fundamental contributions were then made by Walther Nernst, who derived the Nernst equation and detected ionic conduction in heterovalently doped zirconia, which he utilized in his Nernst lamp. Another big step forward was the discovery of the extraordinary properties of alpha silver iodide in 1914. In the late 1920s and early 1930s, the concept of point defects was established by Yakov Il'ich Frenkel, Walter Schottky and Carl Wagner, including the development of point-defect thermodynamics by Schottky and Wagner. In terms of point defects, ionic (and electronic transport in ionic crystals became easy to visualize. In an 'evolving scheme of materials science', point disorder precedes structural disorder, as displayed by the AgI-type solid electrolytes (and other ionic crystals, by ion-conducting glasses, polymer electrolytes and nano-composites. During the last few decades, much progress has been made in finding and investigating novel solid electrolytes and in using them for the preservation of our environment, in particular in advanced solid state battery systems, fuel cells and sensors. Since 1972, international conferences have been held in the field of Solid State Ionics, and the International Society for Solid State Ionics was founded at one of them, held at Garmisch-Partenkirchen, Germany, in 1987.

  2. The ADDITION-Cambridge trial protocol: a cluster – randomised controlled trial of screening for type 2 diabetes and intensive treatment for screen-detected patients

    Directory of Open Access Journals (Sweden)

    Kinmonth Ann

    2009-05-01

    Full Text Available Abstract Background The increasing prevalence of type 2 diabetes poses a major public health challenge. Population-based screening and early treatment for type 2 diabetes could reduce this growing burden. However, the benefits of such a strategy remain uncertain. Methods and design The ADDITION-Cambridge study aims to evaluate the effectiveness and cost-effectiveness of (i a stepwise screening strategy for type 2 diabetes; and (ii intensive multifactorial treatment for people with screen-detected diabetes in primary care. 63 practices in the East Anglia region participated. Three undertook the pilot study, 33 were allocated to three groups: no screening (control, screening followed by intensive treatment (IT and screening plus routine care (RC in an unbalanced (1:3:3 randomisation. The remaining 27 practices were randomly allocated to IT and RC. A risk score incorporating routine practice data was used to identify people aged 40–69 years at high-risk of undiagnosed diabetes. In the screening practices, high-risk individuals were invited to take part in a stepwise screening programme. In the IT group, diabetes treatment is optimised through guidelines, target-led multifactorial treatment, audit, feedback, and academic detailing for practice teams, alongside provision of educational materials for newly diagnosed participants. Primary endpoints are modelled cardiovascular risk at one year, and cardiovascular mortality and morbidity at five years after diagnosis of diabetes. Secondary endpoints include all-cause mortality, development of renal and visual impairment, peripheral neuropathy, health service costs, self-reported quality of life, functional status and health utility. Impact of the screening programme at the population level is also assessed through measures of mortality, cardiovascular morbidity, health status and health service use among high-risk individuals. Discussion ADDITION-Cambridge is conducted in a defined high-risk group

  3. [Development of boomerang-type intramolecular cascade reactions and application to natural product synthesis].

    Science.gov (United States)

    Takasu, K

    2001-12-01

    Intramolecular cascade reaction has received much attention as a powerful methodology to construct a polycyclic framework in organic synthesis. We have been developing "boomerang-type cascade reaction" to construct a variety of polycyclic skeletons efficiently. In the above reactions, a nucleophilic function of substrates changes the character into an electrophile after the initial reaction, and the electrophilic group acts as a nucleophile in the second reaction. That is, the reaction center stepwise moves from one functional group back to the same one via other functional groups. The stream of the electron concerning the cascade reaction is like a locus of boomerang. We show here three different boomerang-type reactions via ionic species or free radicals. 1) Diastereoselective Michael-aldol reaction based on the chiral auxiliary method and enantioselective Michael-aldol reaction by the use of external chiral sources. 2) Short and efficient total syntheses of longifolane sesquiterpenes utilizing intramolecular double Michael addition as a key step. 3) Development of boomerang-type radical cascade reaction of halopolyenes to construct terpenoid skeletons and its regioselectivity.

  4. The cost-effectiveness and budget impact of stepwise addition of bolus insulin in the treatment of type 2 diabetes: evaluation of the FullSTEP trial.

    Science.gov (United States)

    Saunders, Rhodri; Lian, Jean; Karolicki, Boris; Valentine, William

    2014-12-01

    Abstract Background and aims: Intensification of basal insulin-only therapy in type 2 diabetes is often achieved through addition of bolus insulin 3-times daily. The FullSTEP trial demonstrated that stepwise addition (SWA) of bolus insulin aspart was non-inferior to full basal-bolus (FBB) therapy and reduced the rate of hypoglycemia. Here the cost-effectiveness and budget impact of SWA is evaluated. Cost-effectiveness and budget impact models were developed to assess the cost and quality-of-life (QoL) implications of intensification using SWA compared with FBB in the US setting. At assessment, SWA patients added one bolus dose to their current regimen if the HbA1c target was not met. SWA patients reaching three bolus doses used FBB event rates. Outcomes were evaluated at trial end and projected annually up to 5 years. Models captured hypoglycemic events, the proportion meeting HbA1c target, and self-measured blood glucose. Event rates and QoL utilities were taken from trial data and published literature. Costs were evaluated from a healthcare-payer perspective, reported in 2013 USD, and discounted (like clinical outcomes) at 3.5% annually. This analysis applies to patients with HbA1c 7.0-9.0% and body mass index Budget impact analysis estimated that, by moving from FBB to SWA, a health plan with 77,000 patients with type 2 diabetes, of whom 7.8% annually intensified to basal-bolus therapy, would save USD 1304 per intensifying patient over the trial period. SWA of bolus insulin should be considered a beneficial and cost-saving alternative to FBB therapy for the intensification of treatment in type 2 diabetes.

  5. The additive value of N-terminal pro-B-type natriuretic peptide testing at the emergency department in patients with acute dyspnoea.

    Science.gov (United States)

    van der Burg-de Graauw, N; Cobbaert, C M; Middelhoff, C J F M; Bantje, T A; van Guldener, C

    2009-05-01

    B-type natriuretic peptide (BNP) and its inactive counterpart NT-proBNP can help to identify or rule out heart failure in patients presenting with acute dyspnoea. It is not well known whether measurement of these peptides can be omitted in certain patient groups. We conducted a prospective observational study of 221 patients presenting with acute dyspnoea at the emergency department. The attending physicians estimated the probability of heart failure by clinical judgement. NT-proBNP was measured, but not reported. An independent panel made a final diagnosis of all available data including NT-proBNP level and judged whether and how NT-proBNP would have altered patient management. NT-proBNP levels were highest in patients with heart failure, alone or in combination with pulmonary failure. Additive value of NT-proBNP was present in 40 of 221 (18%) of the patients, and it mostly indicated that a more intensive treatment for heart failure would have been needed. Clinical judgement was an independent predictor of additive value of NT-proBNP with a maximum at a clinical probability of heart failure of 36%. NT-proBNP measurement has additive value in a substantial number of patients presenting with acute dyspnoea, but can possibly be omitted in patients with a clinical probability of heart failure of >70%.

  6. Passings to note: Paul Michael Packman, MD; S. Charles Schulz, MD.

    Science.gov (United States)

    Black, Donald W

    2018-02-01

    One of the keys to the success of Annals of Clinical Psychiatry has always been the tireless efforts of our dedicated Editorial Board. We recently lost 2 longtime Editorial Board members, Drs. Paul Michael Packman and S. Charles Schulz. Both will be greatly missed.

  7. Michael Perelman: An ecological future in view of Marxist Economics (Ⅱ)

    Institute of Scientific and Technical Information of China (English)

    Ren Xiaomei

    2009-01-01

    @@ Interviewee profile: Michael Perelman, currently professor of Economics Department of California State University, USA, American economist and economic historian with nearly 20 publications in the field of economics criticism, including Railroading Economics, Manufacturing Discontent, The Perverse Economy, and The Invention of Capitalism.

  8. Wolff-Michael Roth's passibility: at the limits of the constructivist metaphor: a book review

    Science.gov (United States)

    Brendel, Michelle

    2014-12-01

    Wolff-Michael Roth deconstructs the preeminent role conceded to constructivism in Science Education and demonstrates how we learn and know through pain, suffering, love or passion. This review explores his book "Passibility: At the Limits of the Constructivist Metaphor" through the eyes of an outsider to the world of science education.

  9. Assessment of lipid profile of a group of undergraduates in Michael ...

    African Journals Online (AJOL)

    Objective: The aim of this study was to measure the lipid fractions in serum blood samples of apparently healthy undergraduates of Michael Okpara University of Agriculture, Umudike. Methods: A total of one hundred consenting males and females aged between 19-30 years were purposively selected from the ...

  10. Briti ekspert : euroliidus kaob Eestist tööpuudus / Michael Richardson ; interv. Airi Ilisson

    Index Scriptorium Estoniae

    Richardson, Michael

    2003-01-01

    Eestis Suurbritannia tööreformi tutvustava töö- ja sotsiaalnõuniku sõnul on Suurbritannias peaaegu kadunud pikaajaline töötus noorte hulgas, vanematest inimestest on vaid üksikud tööta kauem kui aasta. Vt. samas: Kes on Michael Richardson?

  11. Moral Education and Education in Altruism: Two Replies to Michael Hand

    Science.gov (United States)

    White, John

    2016-01-01

    This article is a critical discussion of two recent papers by Michael Hand on moral education. The first is his "Towards a Theory of Moral Education", published in the "Journal of Philosophy of Education" in 2014 (Volume 48, Issue 4). The second is a chapter called "Beyond Moral Education?" in an edited book of new…

  12. Recollections of Jack Michael and the Application of Skinner's Analysis of Verbal Behavior

    Science.gov (United States)

    Sundberg, Mark L.

    2017-01-01

    Jack Michael offered a course on verbal behavior almost every year throughout his teaching career. Jack was also interested in the application of Skinner's work and in 1976 began to offer a graduate course at Western Michigan University titled Verbal Behavior Applications. Jack and his students pursued the application of Skinner's work on verbal…

  13. From Gouldner to Gramsci: The Making of Michael Apple's "Ideology and Curriculum"

    Science.gov (United States)

    Gottesman, Isaac

    2012-01-01

    Michael Apple's "Ideology and Curriculum", published in 1979, helped initiate a broad turn in the field of education in the United States to Marxist thought as a lens through which to analyze the relationship between school and society. This classic text continues to inform scholarship in the field. While "Ideology" has…

  14. Outside in America: George Michael's music video, public sex and global pop culture

    NARCIS (Netherlands)

    Kooijman, J.

    2004-01-01

    Six months after his controversial arrest for ‘lewd conduct’ at a men’s public restroom in Beverly Hills, British pop star George Michael released the song and music video ‘Outside’ which can be seen as an explicit commentary on the controversy. In this article, I read the music video in three ways:

  15. "Raising Standards" or Reducing Aspirations and Opportunities Still Further? Michael Gove and Examination Reforms

    Science.gov (United States)

    Allen, Martin

    2013-01-01

    Well before the examinations grade crisis of 2012, Michael Gove had set out clear intentions for reforming public examinations. Though he claimed to be improving examinations and assessment by replicating practices that took place in high-performing countries and thus improving the ability of the UK economy to "compete", this…

  16. The Educational Philosophies of Mordecai Kaplan and Michael Rosenak: Surprising Similarities and Illuminating Differences

    Science.gov (United States)

    Schein, Jeffrey; Caplan, Eric

    2014-01-01

    The thoughts of Mordecai Kaplan and Michael Rosenak present surprising commonalities as well as illuminating differences. Similarities include the perception that Judaism and Jewish education are in crisis, the belief that Jewish peoplehood must include commitment to meaningful content, the need for teachers to teach from a position of…

  17. Astronaut C. Michael Foale is briefed on use of Sky Genie

    Science.gov (United States)

    1994-01-01

    Astronaut C. Michael Foale, STS-63 mission specialist, is briefed on the use of Sky Genie device by Karin L. Porter. The device would aid in emergency egress operations aboard a troubled Space Shuttle. Porter, an employee of Rockwell International, helps train astronauts in egress procedures at JSC's Shuttle mockup and integration laboratory.

  18. Gender Relations and Sexual Harassment in the Workplace: Michael Crichton's "Disclosure" as a Teaching Tool.

    Science.gov (United States)

    Comer, Debra R.; Cooper, Elizabeth A.

    1998-01-01

    Describes how to use Michael Crichton's novel "Disclosure" and the film based on it for class discussions of such issues as what constitutes sexual harassment, harassment of men, relationship between sexual harassment and power, organizational responses to harassment, and gender differences in career advancement tactics. (SK)

  19. The power of virtual integration: an interview with Dell Computer's Michael Dell. Interview by Joan Magretta.

    Science.gov (United States)

    Dell, M

    1998-01-01

    Michael Dell started his computer company in 1984 with a simple business insight. He could bypass the dealer channel through which personal computers were then being sold and sell directly to customers, building products to order. Dell's direct model eliminated the dealer's markup and the risks associated with carrying large inventories of finished goods. In this interview, Michael Dell provides a detailed description of how his company is pushing that business model one step further, toward what he calls virtual integration. Dell is using technology and information to blur the traditional boundaries in the value chain between suppliers, manufacturers, and customers. The individual pieces of Dell's strategy--customer focus, supplier partnerships, mass customization, just-in-time manufacturing--may be all be familiar. But Michael Dell's business insight into how to combine them is highly innovative. Direct relationships with customers create valuable information, which in turn allows the company to coordinate its entire value chain back through manufacturing to product design. Dell describes how his company has come to achieve this tight coordination without the "drag effect" of ownership. Dell reaps the advantages of being vertically integrated without incurring the costs, all the while achieving the focus, agility, and speed of a virtual organization. As envisioned by Michael Dell, virtual integration may well become a new organizational model for the information age.

  20. Kunstlik viljastamine - kas rahva püsimajäämise võti? / Michael Cook

    Index Scriptorium Estoniae

    Cook, Michael

    2007-01-01

    Kunstlikust viljastamisest pole üksi abi - vaid siis, kui noored mehed ja naised pööravad selja tarbimiskultusele ja individualismile, hakkab sündimus tõusma taastootmisest kõrgemale, kirjutab BioEdge toimetaja Michael Cook

  1. Training and Mastery of Techniques in Wittgenstein's Later Philosophy: A Response to Michael Luntley

    Science.gov (United States)

    Stickney, Jeff

    2008-01-01

    Responding to Michael Luntley's article, "Learning, Empowerment and Judgement," the author shows he cannot successfully make the following three moves: (1) dissolve the analytic distinction between learning by training and learning by reasoning, while advocating the latter; (2) diminish the role of training in Wittgenstein's philosophy, nor…

  2. Vision and Elusiveness in Philosophy of Education: R. S. Peters on the Legacy of Michael Oakeshott

    Science.gov (United States)

    Williams, Kevin

    2009-01-01

    Despite his elusiveness on important issues, there is much in Michael Oakeshott's educational vision that Richard Peters quite rightly wishes to endorse. The main aim of this essay is, however, to consider Peters' justifiable critique of three features of Oakeshott's work. These are (1) the rigidity of his distinction between vocational and…

  3. Hydrogeochemical and stream sediment reconnaissance basic data for St. Michael Quadrangle, Alaska

    International Nuclear Information System (INIS)

    1981-01-01

    Field and laboratory data are presented for 159 water samples from the St. Michael Quadrangle, Alaska. The samples were collected by Los Alamos National Laboratory; laboratory analysis and data reporting were performed by the Uranium Resource Evaluation Project at Oak Ridge, Tennessee

  4. Gulliver's Travels: Michael Moore the Explorer in "Who to Invade Next"

    Science.gov (United States)

    Beck, Bernard

    2016-01-01

    America is identified as a nation of immigrants. These immigrants are thought to be the source of its subcultures. It is also a nation of individual explorers and inventors. Their activities are also a source of diverse subcultures. Many notable movies have made heroes of such innovators in different fields of endeavor. Michael Moore's movie…

  5. A Critical Analysis of Michael Tippett's "A Child of Our Time"

    Science.gov (United States)

    Vallee, Jean-Sebastien

    2009-01-01

    After more than ten years of thoughtful planning, Michael Tippett (1905-1998) summed up his musical, political, spiritual and philosophical beliefs in his first oratorio, "A Child of Our Time" (1941). Representing the emergence of a new level of confidence and musical maturity for Tippett, the oratorio has become the composer's most widely known…

  6. Q & A with Ed Tech Leaders: Interview with Michael W. Allen

    Science.gov (United States)

    Shaughnessy, Michael F.

    2014-01-01

    Michael W. Allen, the Chairman and CEO of Allen Interactions, is an architect of interactive multimedia learning and is recognized for his many insights, inventions, and presentations. With over 50 years of experience in e-learning, both in academic and corporate settings, he is known for his role in creating Authorware and overseeing the work of…

  7. European Management: an emerging competitive advantage of European nations : A reply to Michael Porter

    NARCIS (Netherlands)

    F.A.J. van den Bosch (Frans); A.A. van Prooijen

    1992-01-01

    textabstractThis article extends the debate begun in the June 1992 issue of EMJ when the authors first criticized Michael Porter's explanatory framework in his Competitive Advantage of Nations (1990), over the role of national culture on the competitive advantage of nations. In this paper, Frans van

  8. New Models at Lasell: Q&A with President Michael Alexander

    Science.gov (United States)

    Harney, John O.

    2018-01-01

    The "New England Journal of Higher Education" ("NEJHE") Executive Editor John O. Harney had the chance to catch up with Lasell College President Michael Alexander about the small Newton, Massachusetts, college's plans to challenge the higher education business model. The interview is presented in this article.

  9. Subjectivity and Cultural Adjustment in Mathematics Education: A Response to Wolff-Michael Roth

    Science.gov (United States)

    Brown, Tony

    2012-01-01

    In this volume, Wolff-Michael Roth provides a critical but partial reading of Tony Brown's book "Mathematics Education and Subjectivity". The reading contrasts Brown's approach with Roth's own conception of subjectivity as derived from the work of Vygotsky, in which Roth aims to "reunite" psychology and sociology. Brown's book, however, focuses on…

  10. Little Mosie from the Margaree: A Biography of Moses Michael Coady.

    Science.gov (United States)

    Welton, Michael R.

    This book examines the life of the Reverend Moses Michael Coady (1890-1959), a Roman Catholic priest who led the Antigonish Movement. During the Antigonish Movement, residents of the small maritime town of Antigonish, Nova Scotia, worked to achieve a nonviolent alternative to communism and fascism and to effect the social and economic…

  11. What Work Do the Concepts of "Language" and "Literature" Do for Michael Rosenak?

    Science.gov (United States)

    Levisohn, Jon A.

    2014-01-01

    Michael Rosenak uses the twin metaphors of "language" and "literature," borrowed from Oakeshott and Peters, to argue that the goal of education is initiation into a language. This goal transcends the study of literature in that language. It includes, as well, the development of the capacity both to critique literature and to…

  12. Michael Faraday on the Learning of Science and Attitudes of Mind.

    Science.gov (United States)

    Crawford, Elspeth

    1998-01-01

    Makes use of Michael Faraday's ideas on learning, focusing on his attitudes toward the unknowns of science and the development of an attitude that improves scientific decision making. This approach acknowledges that there is an inner struggle involved in facing unknowns. (DDR)

  13. An Interview with Michael Horn: Blending Education for High-Octane Motivation

    Science.gov (United States)

    Patterson, Gregory A.

    2012-01-01

    Blended learning holds the potential of improving the way we educate students and of making them more motivated. Blended education--the melding of information technology based distance learning with school attendance--is perhaps the best way to educate students for 21st century skills, says Michael Horn in a "Kappan" interview. Horn points out…

  14. C. P. Snow's "The Two Cultures": Michael Polanyi's Response and Context

    Science.gov (United States)

    Jacobs, Struan

    2011-01-01

    C. P. Snow's "The Two Cultures" controversially contrasted science and literature, suggesting that neither scientists nor literary intellectuals have much in common with, and seldom bother speaking to, the other. Responding to Snow, Michael Polanyi argued that specialization has made modern culture, not twofold but manifold. In his major work,…

  15. Noted astrophysicist Michael S. Turner to Head NSF'S mathematical and physical sciences directorate

    CERN Multimedia

    2003-01-01

    "The National Science Foundation has named celebrated astrophysicist Michael S. Turner of the University of Chicago as Assistant Director for Mathematical and Physical Sciences. He will head a $1 billion directorate that supports research in mathematics, physics, chemistry, materials and astronomy, as well as multidisciplinary programs and education" (1/2 page).

  16. 77 FR 69550 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Science.gov (United States)

    2012-11-19

    ... (Patient Satisfaction Survey Michael E. DeBakey Home Care Program) Activity: Comment Request AGENCY.... DeBakey Home Care Program. DATES: Written comments and recommendations on the proposed collection of...: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form 10-0476. OMB Control Number...

  17. 76 FR 624 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Science.gov (United States)

    2011-01-05

    ... Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program) Activity: Comment Request... satisfaction with the quality of services/care provided by home care program staff. An agency may not conduct... Form 10-0476).'' SUPPLEMENTARY INFORMATION: Title: Patient Satisfaction Survey Michael E. DeBakey Home...

  18. 77 FR 30047 - Notice of Opportunity for Public Comment on Surplus Property Release at Michael J Smith Field...

    Science.gov (United States)

    2012-05-21

    ... Comment on Surplus Property Release at Michael J Smith Field, Beaufort, NC AGENCY: Federal Aviation... J Smith Field, be used for aeronautical purposes. DATES: Comments must be received on or before June... property at the Michael J Smith Field. The property consists of one parcel located on the north side of...

  19. Additive effects of cilnidipine, an L-/N-type calcium channel blocker, and an angiotensin II receptor blocker on reducing cardiorenal damage in Otsuka Long-Evans Tokushima Fatty rats with type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Mori Y

    2014-06-01

    Full Text Available Yutaka Mori,1,2 Shizuka Aritomi,3 Kazumi Niinuma,3 Tarou Nakamura,3 Kenichi Matsuura,1 Junichi Yokoyama,1 Kazunori Utsunomiya1 1Division of Diabetes and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine, Minato-ku, Japan; 2Department of Clinical Research, National Hospital Organization, Utsunomiya National Hospital, Utsunomiya, Japan; 3Research Center, Ajinomoto Pharmaceuticals Co, Ltd, Kanagawa, Japan Abstract: Cilnidipine (Cil, which is an L-/N-type calcium channel blocker (CCB, has been known to provide renal protection by decreasing the activity of the sympathetic nervous system (SNS and the renin–angiotensin system. In this study, we compared the effects of the combination of Cil and amlodipine (Aml, which is an L-type CCB, with an angiotensin (Ang II receptor blocker on diabetic cardiorenal damage in spontaneously type 2 diabetic rats. Seventeen-week-old Otsuka Long-Evans Tokushima Fatty rats were randomly assigned to receive Cil, Aml, valsartan (Val, Cil + Val, Aml + Val, or a vehicle (eight rats per group for 22 weeks. Antihypertensive potencies were nearly equal among the CCB monotherapy groups and the combination therapy groups. The lowering of blood pressure by either treatment did not significantly affect the glycemic variables. However, exacerbations of renal and heart failure were significantly suppressed in rats administered Cil or Val, and additional suppression was observed in those administered Cil + Val. Although Val increased the renin–Ang system, Aml + Val treatment resulted in additional increases in these parameters, while Cil + Val did not show such effects. Furthermore, Cil increased the ratio of Ang-(1–7 to Ang-I, despite the fact that Val and Aml + Val decreased the Ang-(1–7 levels. These actions of Cil + Val might be due to their synergistic inhibitory effect on the activity of the SNS, and on aldosterone secretion through N-type calcium channel antagonism and Ang II

  20. Pentanidium-catalyzed enantioselective phase-transfer conjugate addition reactions

    KAUST Repository

    Ma, Ting

    2011-03-09

    A new chiral entity, pentanidium, has been shown to be an excellent chiral phase-transfer catalyst. The enantioselective Michael addition reactions of tert-butyl glycinate-benzophenone Schiff base with various α,β- unsaturated acceptors provide adducts with high enantioselectivities. A successful gram-scale experiment at a low catalyst loading of 0.05 mol % indicates the potential for practical applications of this methodology. Phosphoglycine ester analogues can also be utilized as the Michael donor, affording enantioenriched α-aminophosphonic acid derivatives and phosphonic analogues of (S)-proline. © 2011 American Chemical Society.

  1. Sodium-glucose co-transporter 2 inhibitors in addition to insulin therapy for management of type 2 diabetes mellitus: A meta-analysis of randomized controlled trials.

    Science.gov (United States)

    Tang, Huilin; Cui, Wei; Li, Dandan; Wang, Tiansheng; Zhang, Jingjing; Zhai, Suodi; Song, Yiqing

    2017-01-01

    Given inconsistent trial results of sodium-glucose cotransporter 2 (SGLT2) inhibitors in addition to insulin therapy for treating type 2 diabetes mellitus (T2DM), a meta-analysis was performed to evaluate the efficacy and safety of this combination for T2DM by searching available randomized trials from PubMed, Embase, CENTRAL and ClinicalTrials.gov. Our meta-analysis included seven eligible placebo-controlled trials involving 4235 patients. Compared with placebo, SGLT2 inhibitor treatment was significantly associated with a mean reduction in HbA1c of -0.56%, fasting plasma glucose of -0.95 mmol/L, body weight of -2.63 kg and insulin dose of -8.79 IU, but an increased risk of drug-related adverse events by 36%, urinary tract infections by 29% and genital infections by 357%. No significant increase was observed in risk of overall adverse events [risk ratio (RR), 1.00], serious adverse events (RR, 0.90), adverse events leading to discontinuation (RR, 1.16), hypoglycaemia events (RR, 1.07) and severe hypoglycaemia events (RR, 1.24). No diabetic ketoacidosis events were reported. Further studies are needed to establish optimal combination type and dose. © 2016 John Wiley & Sons Ltd.

  2. Cyclohexenones Through Addition of Ethyl Acetoacetate to 3-Aryl-1 ...

    African Journals Online (AJOL)

    Chalcone derivatives 3a–i containing a thiophene ring were prepared by the condensation of 1-(thiophen-3-yl)ethanone with aromatic aldehydes in excellent yields. The Michael addition of ethyl acetoacetate 4 to chalcone derivatives 3a–i resulted in the formation of nine novel ethyl 6-aryl ...

  3. Additional Responses to Hugh Heclo's "On Thinking Institutionally"

    Science.gov (United States)

    Lincoln, Timothy D.; Fennell, Robert C.

    2011-01-01

    Issue 13:3 of this journal (July 2010) included a "Conversation" on Hugh Heclo's recent publication "On Thinking Institutionally" (Paradigm Publishers, 2008) with a book review by Robert Fennell and responses by Richard Ascough, Tat-siong Benny Liew, Michael McLain, and Lynne Westfield. Here we publish two additional responses to this same book.…

  4. Current use of metformin in addition to insulin in pediatric patients with type 1 diabetes mellitus: an analysis based on a large diabetes registry in Germany and Austria.

    Science.gov (United States)

    Konrad, Katja; Datz, Nicolin; Engelsberger, Ilse; Grulich-Henn, Jürgen; Hoertenhuber, Thomas; Knauth, Burkhild; Meissner, Thomas; Wiegand, Susanna; Woelfle, Joachim; Holl, Reinhard W

    2015-11-01

    With increasing obesity in childhood and adolescence, weight gain, and insulin resistance become also more frequent in patients with type 1 diabetes mellitus (T1DM). Especially during puberty, insulin therapy often has to be intensified and higher insulin doses are necessary. Some studies point to a beneficial effect of metformin in addition to insulin in these patients. In order to describe current practice and possible benefits, we compared pediatric T1DM patients with insulin plus metformin (n = 525) to patients with insulin therapy only (n = 57 487) in a prospective multicenter analysis. Auxological and treatment data from 58 012 patients aged 1 yr with T1DM in the German/Austrian Diabetes Patienten Verlaufsdokumentation (DPV) registry were analyzed by multivariable mixed regression modeling. Patients with additional metformin were older [median (interquartile range)]: [16.1 (14.1-17.6) vs. 15.2 (11.5-17.5) yr] with female preponderance (61.0 vs. 47.2%, p 1). They had higher body mass index-standard deviation score (BMI-SDS) [+2.03 (+1.29 to +2.56) vs. +0.51 (-0.12 to +1.15); p 1] and glycated hemoglobin (HbA1c) (9.0 vs. 8.6%, p 1). Hypertension (43.7 vs. 24.8%) and dyslipidemia (58.4 vs. 40.6%) were significantly more prevalent. Adjusted insulin dose was significantly higher (0.98 vs. 0.93 IU/kg bodyweight). In a subgroup of 285 patients followed-up longitudinally (average treatment period 1.42 yr), addition of metformin resulted in a slight reduction of BMI-SDS [-0.01 (-2.01 to +1.40)], but did not improve HbA1c or insulin requirement. Additional metformin therapy in T1DM is primarily used in obese females. Additional therapy with metformin was associated with minor benefits. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. The effects of additional black carbon on the albedo of Arctic sea ice: variation with sea ice type and snow cover

    Directory of Open Access Journals (Sweden)

    A. A. Marks

    2013-07-01

    Full Text Available The response of the albedo of bare sea ice and snow-covered sea ice to the addition of black carbon is calculated. Visible light absorption and light-scattering cross-sections are derived for a typical first-year and multi-year sea ice with both "dry" and "wet" snow types. The cross-sections are derived using data from a 1970s field study that recorded both reflectivity and light penetration in Arctic sea ice and snow overlying sea ice. The variation of absorption cross-section over the visible wavelengths suggests black carbon is the dominating light-absorbing impurity. The response of first-year and multi-year sea ice albedo to increasing black carbon, from 1 to 1024 ng g−1, in a top 5 cm layer of a 155 cm-thick sea ice was calculated using a radiative-transfer model. The albedo of the first-year sea ice is more sensitive to additional loadings of black carbon than the multi-year sea ice. An addition of 8 ng g−1 of black carbon causes a decrease to 98.7% of the original albedo for first-year sea ice compared to a decrease to 99.7% for the albedo of multi-year sea ice, at a wavelength of 500 nm. The albedo of sea ice is surprisingly unresponsive to additional black carbon up to 100 ng g−1 . Snow layers on sea ice may mitigate the effects of black carbon in sea ice. Wet and dry snow layers of 0.5, 1, 2, 5 and 10 cm depth were added onto the sea ice surface. The albedo of the snow surface was calculated whilst the black carbon in the underlying sea ice was increased. A layer of snow 0.5 cm thick greatly diminishes the effect of black carbon in sea ice on the surface albedo. The albedo of a 2–5 cm snow layer (less than the e-folding depth of snow is still influenced by the underlying sea ice, but the effect of additional black carbon in the sea ice is masked.

  6. Effect of boron additions on phase formation and magnetic properties of TbCu{sub 7}-type melt spun SmFe ribbons

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Chuanjiang; Yu, Dunbo, E-mail: yudb2008@126.com; Li, Kuoshe; Luo, Yang; Jin, Jinling; Lu, Shuo; Li, Hongwei; Mao, Yongjun; Quan, Ningtao

    2016-08-15

    Melt spun ribbons of a series of SmFe{sub 12}B{sub x} (x=0.0, 0.5, 0.75, 1.0, 1.25, and 1.5) have been prepared by the melt spinning technique. Sm–Fe–B melt spun ribbons with single phase TbCu{sub 7}-type structure were prepared from the SmFe{sub 12}B{sub x} (x=0.5, 0.75, and 1.0) alloys at the surface velocity around 40 m/s. The addition of boron not only inhibits the appearance of soft magnetic phase α-Fe, but also enhances the ability of amorphous formation for melt spun Sm–Fe ribbons. The concentration of boron atoms, however, exceeds the limit of the solubility (x>1.0) of Sm–Fe alloys, which does not impede the appearance of α-Fe but accelerates the formation of metastable phase Sm{sub 2}Fe{sub 23}B{sub 3} that is unfavorable to their magnetic properties. Moreover, it is found that the addition of boron whose concentration is 0.0≤x≤0.75 can stabilize the metastable TbCu{sub 7}-type structure because of the increase of the lattice parameter ratio c/a. The magnetic properties of as-annealed SmFe{sub 12}B{sub 1.0} melt spun ribbons with an energy product of 2.19MGOe, a coercivity of 2.36 kOe and a remanence of 4.8 kGs have been achieved. The microstructural characteristics of as-annealed melt spun SmFe{sub 12} and SmFe{sub 12}B{sub 1.0} ribbons have been discussed as well. The following sequence of the hyperfine field H(6l)additions can inhibit the emergence of the soft magnetic phase α-Fe and improve the ability of amorphous formation. • There is a solubility limit of boron atom within melt spun Sm–Fe alloys with TbCu{sub 7}-type structure, and the

  7. Effect of boron additions on phase formation and magnetic properties of TbCu7-type melt spun SmFe ribbons

    International Nuclear Information System (INIS)

    Zheng, Chuanjiang; Yu, Dunbo; Li, Kuoshe; Luo, Yang; Jin, Jinling; Lu, Shuo; Li, Hongwei; Mao, Yongjun; Quan, Ningtao

    2016-01-01

    Melt spun ribbons of a series of SmFe 12 B x (x=0.0, 0.5, 0.75, 1.0, 1.25, and 1.5) have been prepared by the melt spinning technique. Sm–Fe–B melt spun ribbons with single phase TbCu 7 -type structure were prepared from the SmFe 12 B x (x=0.5, 0.75, and 1.0) alloys at the surface velocity around 40 m/s. The addition of boron not only inhibits the appearance of soft magnetic phase α-Fe, but also enhances the ability of amorphous formation for melt spun Sm–Fe ribbons. The concentration of boron atoms, however, exceeds the limit of the solubility (x>1.0) of Sm–Fe alloys, which does not impede the appearance of α-Fe but accelerates the formation of metastable phase Sm 2 Fe 23 B 3 that is unfavorable to their magnetic properties. Moreover, it is found that the addition of boron whose concentration is 0.0≤x≤0.75 can stabilize the metastable TbCu 7 -type structure because of the increase of the lattice parameter ratio c/a. The magnetic properties of as-annealed SmFe 12 B 1.0 melt spun ribbons with an energy product of 2.19MGOe, a coercivity of 2.36 kOe and a remanence of 4.8 kGs have been achieved. The microstructural characteristics of as-annealed melt spun SmFe 12 and SmFe 12 B 1.0 ribbons have been discussed as well. The following sequence of the hyperfine field H(6l)additions can inhibit the emergence of the soft magnetic phase α-Fe and improve the ability of amorphous formation. • There is a solubility limit of boron atom within melt spun Sm–Fe alloys with TbCu 7 -type structure, and the metastable phase Sm 2 Fe 23 B 3 will appear when the content of boron

  8. [Carbon storage of forest vegetation and allocation for main forest types in the east of Da-xing'an Mountains based on additive biomass model].

    Science.gov (United States)

    Peng, Wei; Dong, Li Hu; Li, Feng Ri

    2016-12-01

    Based on the biomass investigation data of main forest types in the east of Daxing'an Mountains, the additive biomass models of 3 main tree species were developed and the changes of carbon storage and allocation of forest community of tree layer, shrub layer, herb layer and litter layer from different forest types were discussed. The results showed that the carbon storage of tree layer, shrub layer, herb layer and litter layer for Rhododendron dauricum-Larix gmelinii forest was 71.00, 0.34, 0.05 and 11.97 t·hm -2 , respectively. Similarly, the carbon storage of the four layers of Ledum palustre-L. gmelinii forest was 47.82, 0.88, 0, 5.04 t·hm -2 , 56.56, 0.44, 0.04, 8.72 t·hm -2 for R. dauricum-mixed forest of L. gmelinii-Betula platyphylla, 46.21, 0.66, 0.07, 6.16 t·hm -2 for L. palustre-mixed forest of L. gmelinii-B. platyphylla, 40.90, 1.37, 0.04, 3.67 t·hm -2 for R. dauricum-B. platyphylla forest, 36.28, 1.12, 0.18, 4.35 t·hm -2 for L. palustre-B. platyphylla forest. The carbon storage of forest community for the understory vegetation of R. dauricum was higher than that of the forest with L. palustre. In the condition of similar circumstances for the understory, the order of carbon storage for forest community was L. gmelinii forest > the mixed forest of L. gmelinii-B. platyphylla > B. platyphylla forest. The carbon storage of different forest types was different with the order of R. dauricum-L. gmelinii forest (83.36 t·hm -2 )> R. dauricum-mixed forest of L. gmelinii-B. platyphylla (65.76 t·hm -2 ) > L. palustre-L. gmelinii forest (53.74 t·hm -2 )> L. palustre-mixed forest of L. gmelinii-B. platyphylla (53.10 t·hm -2 )> R. dauricum-B. platyphylla forest (45.98 t·hm -2 ) > L. palustre-B. platyphylla forest (41.93 t·hm -2 ). The order of carbon storage for the vertical distribution in forest communities with diffe-rent forest types was the tree layer (85.2%-89.0%) > litter layer (8.0%-14.4%) > shrub layer (0.4%-2.7%) > herb layer (0-0.4%).

  9. Michael Faraday and the concept of atomic structure

    International Nuclear Information System (INIS)

    Pocock, R.F.

    1991-01-01

    Written to commemorate the bicentenary of Faraday's birth, this article surveys his influence on atomic theory during the 19th and early 20th centuries. It identifies which developments were derived from projects which he had started; it shows that his ideas and methods determined the direction of researches which he had not himself initiated. The account is in the form of a chronological narrative. This is based entirely on published sources, and the treatment is non-mathematical. In consequence it contains no new factual data. The presentation of Faraday's work in this particular context is, however, original. Although not covering studies of the nucleus - which were mostly later than the period considered -this article describes the origins of modern theories of atomic structure reasonably completely. It is a useful overview for engineers unfamiliar with details of the history of physics. In addition, it is a case-study of the persistence of scientific ideas in researches occupying a century or more. (author)

  10. Addition of a Nitric Oxide Donor to an Angiotensin II Type 1 Receptor Blocker May Cancel Its Blood Pressure-Lowering Effects.

    Science.gov (United States)

    Yahiro, Eiji; Miura, Shin-Ichiro; Suematsu, Yasunori; Matsuo, Yoshino; Arimura, Tadaaki; Kuwano, Takashi; Imaizumi, Satoshi; Iwata, Atsushi; Uehara, Yoshinari; Saku, Keijiro

    2015-01-01

    While physiological levels of nitric oxide (NO) protect the endothelium and have vasodilatory effects, excessive NO has adverse effects on the cardiovascular system. Recently, new NO-releasing pharmacodynamic hybrids of angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) have been developed.We analyzed whether olmesartan with NO-donor side chains (Olm-NO) was superior to olmesartan (Olm) for the control of blood pressure (BP). Although there was no significant difference in binding affinity to AT1 wild-type (WT) receptor between Olm and Olm-NO in a cell-based binding assay, the suppressive effect of Olm-NO on Ang II-induced inositol phosphate (IP) production was significantly weaker than that of Olm in AT1 WT receptor-expressing cells. While Olm had a strong inverse agonistic effect on IP production, Olm-NO did not. Next, we divided 18 C57BL mice into 3 groups: Ang II (infusion using an osmotic mini-pump) as a control group, Ang II (n = 6) + Olm, and Ang II (n = 6) + Olm-NO groups (n = 6). Olm-NO did not block Ang II-induced high BP after 10 days, whereas Olm significantly decreased BP. In addition, Olm, but not Olm-NO, significantly reduced the ratio of heart weight to body weight (HW/BW) with downregulation of the mRNA levels of atrial natriuretic peptide.An ARB with a NO-donor may cancel BP-lowering effects probably due to excessive NO and a weak blocking effect by Olm-NO toward AT1 receptor activation.

  11. An introduction to the avian gut microbiota and the effects of yeast-based prebiotic-type compounds as potential feed additives

    Directory of Open Access Journals (Sweden)

    Stephanie M. Roto

    2015-09-01

    Full Text Available The poultry industry has been searching for a replacement for antibiotic growth promoters in poultry feed as public concerns over the use of antibiotics and the appearance of antibiotic resistance has become more intense. An ideal replacement would be feed amendments that could eliminate pathogens and disease while retaining economic value via improvements on body weight and feed conversion ratios. Establishing a healthy gut microbiota can have a positive impact on growth and development of both body weight and the immune system of poultry, while reducing pathogen invasion and disease. The addition of prebiotics to poultry feed represents one such recognized way to establish a healthy gut microbiota. Prebiotics are feed additives, mainly in the form of specific types of carbohydrates that are indigestible to the host while serving as substrates to select beneficial bacteria and altering the gut microbiota. Beneficial bacteria in the ceca easily ferment commonly studied prebiotics, producing short chain fatty acids (SCFA, while pathogenic bacteria and the host are unable to digest their molecular bonds. Prebiotic-like substances are less commonly studied, but show promise in their effects on the prevention of pathogen colonization, improvements on the immune system, and host growth. Inclusion of yeast and yeast derivatives as probiotic and prebiotic-like substances, respectively, in animal feed has demonstrated positive associations with growth performance and modification of gut morphology. This review will aim to link together how such prebiotics and prebiotic-like substances function to influence the native and beneficial microorganisms that result in a diverse and well-developed gut microbiota.

  12. Additive Interaction of MTHFR C677T and MTRR A66G Polymorphisms with Being Overweight/Obesity on the Risk of Type 2 Diabetes

    Directory of Open Access Journals (Sweden)

    Xueyuan Zhi

    2016-12-01

    Full Text Available Although both methylenetetrahydrofolate reductase (MTHFR C677T and methionine synthase reductase (MTRR A66G polymorphisms have been associated with type 2 diabetes (T2D, their interactions with being overweight/obesity on T2D risk remain unclear. To evaluate the associations of the two polymorphisms with T2D and their interactions with being overweight/obesity on T2D risk, a case-control study of 180 T2D patients and 350 healthy controls was conducted in northern China. Additive interaction was estimated using relative excess risk due to interaction (RERI, attributable proportion due to interaction (AP and synergy index (S. After adjustments for age and gender, borderline significant associations of the MTHFR C677T and MTRR A66G polymorphisms with T2D were observed under recessive (OR = 1.43, 95% CI: 0.98–2.10 and dominant (OR = 1.43, 95% CI: 1.00–2.06 models, respectively. There was a significant interaction between the MTHFR 677TT genotype and being overweight/obesity on T2D risk (AP = 0.404, 95% CI: 0.047–0.761, in addition to the MTRR 66AG/GG genotypes (RERI = 1.703, 95% CI: 0.401–3.004; AP = 0.528, 95% CI: 0.223–0.834. Our findings suggest that individuals with the MTHFR 677TT or MTRR 66AG/GG genotypes are more susceptible to the detrimental effect of being overweight/obesity on T2D. Further large-scale studies are still needed to confirm our findings.

  13. Efficacy of Additional Canagliflozin Administration to Type 2 Diabetes Patients Receiving Insulin Therapy: Examination of Diurnal Glycemic Patterns Using Continuous Glucose Monitoring (CGM).

    Science.gov (United States)

    Matsumura, Mihoko; Nakatani, Yuki; Tanka, Seiichi; Aoki, Chie; Sagara, Masaaki; Yanagi, Kazunori; Suzuki, Kunihiro; Aso, Yoshimasa

    2017-08-01

    The efficacy of administering a sodium-glucose cotransporter 2 inhibitor during insulin therapy has not been established. In this study, we examined its effects based on diurnal glycemic patterns using continuous glucose monitoring (CGM). The subjects were 15 patients who had received insulin therapy for 1 year or more. A CGM device was attached to all subjects for 1 week. The administration of canagliflozin at 100 mg was started 4 days after attachment. The mean glucose concentrations, standard deviation (SD), mean amplitude of glycemic excursions (MAGE), mean of daily difference of blood glucose (MODD), and area under the curve (AUC) (≥180, glucose concentrations decreased from 161.1 to 139.1 mg/dL (P AUC of ≥180, i.e., the total area of blood glucose levels at or above 180 on the blood glucose curve of CGM, decreased from 339.1 to 113.6 mg/dL (P AUC of blood glucose levels below 70 on the blood glucose curve of CGM, slightly decreased from 1.6 to 0.3 mg/dL (P = 0.08). The total number of basal insulin units decreased from 128 to 76, and that of bolus insulin decreased from 266 to 154; the dose of insulin could be markedly decreased. In addition, the mean 8-OHdG level decreased from 11.4 to 10.8 ng/mg Cre (P blood glucose changes in type 2 diabetes using insulin. In addition, the results suggest its antioxidant actions. University Hospital Medical Information Network (UMIN no. 000019429).

  14. Brändi näkyy musiikkivideossa : Esimerkkitapaus Michael Jackson

    OpenAIRE

    Kontinen, Noora

    2016-01-01

    Tutkin opinnäytetyössäni brändin ja musiikkivideon suhdetta toisiinsa. Työssä käsitellään lyhyesti myös tähteyttä. Esittelen ensin vähän historiaa ja peruskäsitteitä, minkä jälkeen käytän Michael Jacksonin Billie Jean -musiikkivideota esimerkkinä tutkiessani Michael Jacksonin brändiä. Teoksessa käytetään lähdeaineistoa sekä omaa analyysia. Keskityn tarkastelemaan musiikkivideoita, ja niihin liittyviä sisältöjä yleisesti, ei niinkään teknisesti. Toivon, että työstäni on apua jollekin,...

  15. Interviews with Michael Baxandall, February 3rd and 4th, 1994, Berkeley, CA

    Directory of Open Access Journals (Sweden)

    Allan Langdale

    2009-12-01

    Full Text Available The following interviews with Michael Baxandall were conducted in Berkeley on February 3rd and 4th of 1994. The content of these interviews include general responses about developments in art history in the years between 1960 and 1985, a period of dramatic modifications in the discipline. Among the issues are the rise of the social history of art and the sources from anthropology that informed Baxandall’s concept of the ‘Period Eye’. Baxandall talks about his own work, his personal intellectual history, and the scholars of past and current generations who influenced him. Other topics include Baxandall’s professional trajectory, the Warburg Library, and aspects of cultural history having to do with Renaissance Humanism. These interviews first appeared as an appendix to the PhD dissertation by Allan Langdale, Art History and Intellectual History: Michael Baxandall’s Work between 1963 and 1985, U. C. Santa Barbara, 1995.

  16. [An exceptional human relationship (Michael P. Kierkegaard, Søren Kierkegaard)].

    Science.gov (United States)

    Jacobs, R

    1978-01-01

    There were a father and a son, Michael and Sören Kierkegaard, both highly talented, imaginitive, witty, humorous, especially interested in shrewd dialectrical dialogues respectively debates, both profound melancholy ponderers. But according to very own individuality their congeniality wasn't absolute. The father, being under a questionable rigorous opinion of sin, suffered from undeserved divine grace since early childhood. And Michael Kierkegaard made Sören anxious with the religious experience of original sin. This anxiety moved (touched or affected) the sensitive son mighty. Nevertheless he should not despair hopelessly like his unlucky father. On the contrary: Sørens incomparable melancholy, mental agony and anxiety (fear or anguish) forced the faith, existing independently of them, in a radical refining. That is why Sören Kierkegaard succeeded in sublimation of all psychological and philosophic (al) attitudes (or opinions) in the sphere of religiousness. And the result? A novel philosophy of life: Christian existentialism.

  17. Michael K. Scullin: Psi Chi/APA Edwin B. Newman Graduate Research Award.

    Science.gov (United States)

    2011-11-01

    Presents Michael K. Scullin as the 2011 winner of the American Psychological Association Psi Chi/APA Edwin B. Newman Graduate Research Award. "For an outstanding research paper that examines the relationship between prospective memory in executing a goal and various lapses of time from 20 minutes up to a 12- hour wake delay and a 12-hour sleep delay. The results suggest that consolidation processes active during sleep increase the probability of goal execution. The paper, titled 'Remembering to Execute a Goal: Sleep On It!' was published in Psychological Science in 2010 and was the basis for Michael K. Scullin's selection as the recipient of the 2011 Psi Chi/APA Edwin B. Newman Graduate Research Award. Mark A. McDaniel, PhD, served as faculty research advisor." (PsycINFO Database Record (c) 2011 APA, all rights reserved). 2011 APA, all rights reserved

  18. Navigating Transition: Freedom, Limitation and the Post-colonial Persona in Michael Ondaatje's The Cat's Table

    Directory of Open Access Journals (Sweden)

    Alaa Alghamdi

    2012-11-01

    Full Text Available Michael Ondaatje's 2011 novel The Cat's Table follows a young boy's voyage from Colombo, Sri Lanka to London, England. Through this character and the unique environment of the ship, which forms a compelling sense of transitory place, Ondaatje explores liminality and its relationship with limitations or barriers. The young protagonist, Michael, and his companions enjoy an unusual level of freedom aboard the contained and hierarchically segmented ship. Polarization and transition between Eastern and Western culture is present but pales in importance compared to the validation of the self that is located within and defined by the sense of the in-between, an essential rite of passage undertaken before re-joining society.

  19. Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition

    Science.gov (United States)

    Rothdiener, Miriam; Hegemann, Miriam; Uynuk-Ool, Tatiana; Walters, Brandan; Papugy, Piruntha; Nguyen, Phong; Claus, Valentin; Seeger, Tanja; Stoeckle, Ulrich; Boehme, Karen A.; Aicher, Wilhelm K.; Stegemann, Jan P.; Hart, Melanie L.; Kurz, Bodo; Klein, Gerd; Rolauffs, Bernd

    2016-10-01

    Using matrix elasticity and cyclic stretch have been investigated for inducing mesenchymal stromal cell (MSC) differentiation towards the smooth muscle cell (SMC) lineage but not in combination. We hypothesized that combining lineage-specific stiffness with cyclic stretch would result in a significantly increased expression of SMC markers, compared to non-stretched controls. First, we generated dense collagen type I sheets by mechanically compressing collagen hydrogels. Atomic force microscopy revealed a nanoscale stiffness range known to support myogenic differentiation. Further characterization revealed viscoelasticity and stable biomechanical properties under cyclic stretch with >99% viable adherent human MSC. MSCs on collagen sheets demonstrated a significantly increased mRNA but not protein expression of SMC markers, compared to on culture flasks. However, cyclic stretch of MSCs on collagen sheets significantly increased both mRNA and protein expression of α-smooth muscle actin, transgelin, and calponin versus plastic and non-stretched sheets. Thus, lineage-specific stiffness and cyclic stretch can be applied together for inducing MSC differentiation towards SMCs without the addition of recombinant growth factors or other soluble factors. This represents a novel stimulation method for modulating the phenotype of MSCs towards SMCs that could easily be incorporated into currently available methodologies to obtain a more targeted control of MSC phenotype.

  20. Low-loss Z-type barium hexaferrite composites from nanoscale ZnAl2O4 addition for high-frequency applications

    Science.gov (United States)

    Zheng, Zongliang; Feng, Quanyuan; Harris, Vincent G.

    2018-05-01

    In this study, nanocrystalline ZnAl2O4 (ZA) were introduced to Z-type barium hexaferrite (Co2Z) and the effects of ZA addition upon the crystal-phase composition, microstructure, permeability and permittivity as well as losses characteristics over a wide frequency range of 10 MHz-1 GHz have been systematically investigated. With increasing ZA content (x) from 0 to 15 wt%, the permeability μ' at low frequencies decreased from 12.0 to 4.3, while the permittivity ɛ' was decreased from 27.4 to 10.7. Correspondingly, the frequency stability of permeability and permittivity were improved and the losses were effectively reduced. When x is in the range of 5-10 wt%, the magnetic loss tan δμ is in the order of 10-2 and the dielectric loss tan δɛ is in the order of 10-3 at 300 MHz, which is lower by one order of magnitude compared with that of undoped Co2Z. The modified magnetic and dielectric properties are closely related to the changing phase composition and microstructure.

  1. Learned Helplessness Encountered by Michael Oher in the Blind Side Movie

    OpenAIRE

    PAMUNGKAS, DIMAS PROBO

    2014-01-01

    Pamungkas, Dimas Probo. 2014. Learned Helplessness Encountered by Michael Oher in The Blind Side Movie. Study Program of English, Department of Languages and Literature, Faculty of Culture Studies, Universitas Brawijaya. Supervisor: Dyah Eko Hapsari;Co-supervisor: Sarlettina Vidyayani EkaKeywords: Learned Helplessness, African-American, Psychological, Social Behavior, Depression, The Blind Side.Social behavior shows several interactions between person and social situations, which stress...

  2. Dropping The Bomb? On Critical and Cinematic Reactions to Michael Ondaatje's The English Patient

    OpenAIRE

    Pesch, Josef

    2018-01-01

    This paper analyses Anthony Minghella's film adaptation of Michael Ondaatje’s The English Patient. It aims at establishing patterns of transformation and strategies of adaptation. Not only the nostalgie romanticisation, but also the de-politicisation of the novel is critically scrutinized. As dropping all reference to the atomic bomb from the film is the most blatant example of deviation from the novel, critical and political background is provided which may explain this act of self-censorshi...

  3. Horror movie aspects and experimentation in Michael Jackson’s Thriller music video

    OpenAIRE

    Vargas, Herom; Universidade Municipal de São Caetano do Sul - USCS; Gonçalves, Rafael; Universidade Municipal de São Caetano do Sul - USCS

    2016-01-01

    This article analyzes the use of elements from the horror fi lm genre in the music video Thriller (1982), by Michael Jackson, as experimentation within the field of pop music. Based on the semiotics of culture, grounded on the concepts of cultural text, semiosphere, border and modeling, developed by Iuri Lotman, the analysis identified innovations in the use of horror as humor and, in the music, modeling of creatures, moving among horror, the fantastic and the reality.Keywords: horror, music ...

  4. Review: Cornelia Behnke & Michael Meuser (1999). Geschlechterforschung und qualitative Methoden [Gender Research and Qualitative Methods

    OpenAIRE

    Nicola Döring

    2001-01-01

    In less than 100 pages Cornelia BEHNKE and Michael MEUSER explain how gender studies evolved from women's studies and what feminist methodology is all about. They also discuss the interrelation of qualitative research and gender studies. The great potential of qualitative research based on a constructivist gender concept is demonstrated with a group discussion study involving different men only groups. Finally the authors deal with the question of how the researcher's gender affects both data...

  5. Feeding Health: Michael Pollan on Improving Public Health through the Food Systems

    Centers for Disease Control (CDC) Podcasts

    2009-08-19

    In this podcast, author Michael Pollan discusses his March 2009 visit to CDC and offers his thoughts on the intersection between the government, the food systems, and public health.  Created: 8/19/2009 by National Center for Environmental Health (NCEH), National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Office of Sustainability.   Date Released: 4/15/2010.

  6. En memoria de Michael Jiménez (1948-2001

    Directory of Open Access Journals (Sweden)

    Mauricio Archila Neira

    2001-01-01

    Full Text Available El 1 de septiembre de 2001 murió el historiador Michael Jiménez. Su apellido provenía de España de donde emigró su abuelo en busca de mejor suerte al otro lado del Atlántico. Nacido en el pequeño pueblo de Merced, California (Estados Unidos en agosto de 1948 en el seno de una familia obrera, Michael vivió su infancia en Colombia. A fines de ese año, su padre se desplazó a estas tierras para ser funcionario de la Texas, una multinacional petrolera que tenía sus reales en Puerto Boyacá. Michael estudió en el colegio Nueva Granada -becado por la Texas- hasta los catorce años. En dicho colegio fue compañero de pupitre de Herbert Braun, descendiente a su vez de una familia de emigrantes a Colombia, y con quien la vida lo juntaría de nuevo en las tierras del norte y en oficios similares.

  7. Between Irish National Cinema and Hollywood: Neil Jordan’s Michael Collins

    Directory of Open Access Journals (Sweden)

    Raita Merivirta-Chakrabarti

    2007-03-01

    Full Text Available When Neil Jordan’s film Michael Collins was released in 1996, it was seen by some as a Hollywood epic, by others as a great national film. I would argue that Michael Collins combines these two traditions and occupies a space between Irish national cinema and Hollywood. The subject matter, the creative talent and the locations were Irish and the film was produced by using the Irish filmmaking infrastructure and the Irish government’s support mechanisms, but it was largely financed and distributed by a Hollywood studio. Also, to make it more appealing especially globally, but probably also locally (since Hollywood is now the international standard, it makes use of Hollywood conventions, making it accessible to international audiences as well. Despite the Hollywood mode, the fact remains that Michael Collins is a national film text, and Jordan does not make too many concessions to the non-Irish audiences.

  8. A celebration of mechanics: from nano to macro. The J. Michael T. Thompson Festschrift issue.

    Science.gov (United States)

    Elishakoff, Isaac

    2013-06-28

    This Theme Issue is dedicated to the topic 'Mechanics: from nano to macro' and marks the 75th birthday of Dr J. Michael T. Thompson, Fellow of the Royal Society, whose current affiliations are as follows: (i) Honorary Fellow, Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge; (ii) Emeritus Professor of Nonlinear Dynamics, Department of Civil, Environmental and Geomatic Engineering, University College London; and (iii) Professor of Theoretical and Applied Dynamics (Distinguished Sixth Century Chair, part-time), University of Aberdeen. He also serves as Chairman of the Board of Directors at ES-Consult (consulting engineers) in Copenhagen, Denmark. The pertinent question that arises from the very start is: should we first salute Michael and then describe the Theme Issue, or vice versa? Indeed, according to Blaise Pascal (1623-1662), the last thing one discovers in composing a work is what to put first. I would like to take the liberty of deviating from the tradition of the Philosophical Transactions and start with the tribute to Michael; after all he is the prime cause of this Theme Issue.

  9. The conceptualization of love in religious thought of George Florovsky and Michael Pomazansky

    Directory of Open Access Journals (Sweden)

    Pavenkov Oleg Vladimirovich

    2015-04-01

    Full Text Available The present article is concerned with the question of conceptualization of love in works of Fr. George Florovsky and Fr. Michael Pomazansky, Russian religious thinkers and theologists. We are studying the meaning and appropriacy of two words, ‘love’ (English and ‘любовь’ (Russian, that are the best to represent the agapelogical positive evaluation in Russian religious thought. Data for study was taken from ten different articles and extracts from books written by Fr. George Florovsky and Fr. Michael Pomazansky. On the basis of this analysis we develop semantic explications of words ‘love’ and ‘любовь’ as Christian spiritual concepts within the framework of theoretical approach of Natural Semantic Metalanguage (NSM. In summary we state that this article discusses, describes and determines some similarities and differences in understanding of concept ‘love’ in the affore-referenced works by Fr. George Florovsky and Fr. Michael Pomazansky.

  10. Addition of bone morphogenetic protein type 2 to ascorbate and β-glycerophosphate supplementation did not enhance osteogenic differentiation of human adipose-derived stem cells

    Directory of Open Access Journals (Sweden)

    Ariadne Cristiane Cabral Cruz

    2012-12-01

    Full Text Available Bone morphogenetic protein type 2 (BMP-2 is a potent local factor, which promotes bone formation and has been used as an osteogenic supplement for mesenchymal stem cells. OBJECTIVES: This study evaluated the effect of a recombinant BMP-2 as well as the endogenous BMP-4 and BMP-7 in the osteogenic differentiation of adipose-derived stem cells (ASCs in medium supplemented with ascorbate and β-glycerophosphate. MATERIAL AND METHODS: Human ASCs were treated with osteogenic medium in the presence (ASCs+OM+BMP-2 or absence (ASCs+OM of BMP-2. The alkaline phosphatase (ALP activity was determined and the extracellular matrix mineralization was evaluated by Von Kossa staining and calcium quantification. The expressions of BMP-4, BMP-7, Smad1, Smad4, and phosphorylated Smad1/5/8 were analyzed by western blotting. Relative mRNA expressions of Smad1, BMP receptor type II (BMPR-II, osteonectin, and osteocalcin were evaluated by qPCR. Results: ASCs+OM demonstrated the highest expression of BMP-4 and BMP-7 at days 21 and 7, respectively, the highest levels of BMPR-II mRNA expression at day 28, and the highest levels of Smad1 mRNA at days 14 and 28. ASCs+OM+BMP-2 demonstrated the highest levels of Smad1 mRNA expression at days 1, 7, and 21, the highest expression of Smad1 at day 7, the highest expression of Smad4 at day 14, the highest ALP activity at days 14 and 21, and expression of phosphorylated Smad1/5/8 at day 7. ASCs+OM and ASCs+OM+BMP2 showed similar ALP activity at days 7 and 28, similar osteonectin and osteocalcin mRNA expression at all time periods, and similar calcium depositions at all time periods. CONCLUSIONS: We concluded that human ASCs expressed endogenous BMP-4 and BMP-7. Moreover, the supplementation of ASCs with BMP-2 did not increase the level of osteogenic markers in the initial (ALP activity, intermediate (osteonectin and osteocalcin, or final (calcium deposition phases, suggesting that the exogenous addition of BMP-2 did not improve

  11. A perspectiva de Michael Apple para os estudos das políticas educacionais

    Directory of Open Access Journals (Sweden)

    Luís Armando Gandin

    Full Text Available Resumo Este artigo tem como objetivo analisar as contribuições de Michael Apple para o campo da pesquisa em políticas educacionais. Na extensa obra de Michael Apple, destacamos seis elementos que podem auxiliar aqueles que estão interessados na área de políticas em educação: o princípio epistemológico da análise relacional; o exame do Estado como relação; a herança de Antonio Gramsci e de Raymond Williams que Michael Apple incorpora no uso de conceitos como hegemonia e senso comum; a análise que Michael Apple faz das políticas educacionais como políticas culturais, como disputas por visão de mundo, como luta por consolidação de uma hegemonia que vai além do econômico; a sua postura de pesquisador; e a capacidade que Michael Apple tem de ir além da lógica da reprodução e determinação para enfatizar o papel da agência e da contra-hegemonia. Através de exemplos práticos da própria obra de Apple e de outras pesquisas empíricas, apresentam-se as implicações de cada um dos seis pontos acima citados para os pesquisadores interessados na área de políticas educacionais. Conclui-se que muitas das contribuições de Apple podem auxiliar em pesquisas nessa área, tendo em vista a discussão que o autor realiza em sua obra e sua crítica ao determinismo econômico nas análises do campo educacional, salientando a importância, assim, de aspectos que estão relacionados à esfera da cultura.

  12. Tagasipöördumine esteetika juurde = Return to aesthetics / Keith Moxey, Michael Ann Holly ; interv. Anu Allas

    Index Scriptorium Estoniae

    Moxey, Keith

    2007-01-01

    Ameerika kunstiajaloolased Keith Moxey ning Michael Ann Holly tutvustavad uut lähenemist kunstiajaloole (new art history). Nn. naasmine esteetika juurde tähendab püüet integreerida kunstiajalukku ja -teooriasse uuesti ja tugevamalt kunstiteos

  13. Review: Barr, Michael and Zlatko Skrbiš (2008, Constructing Singapore. Elitism, Ethnicity and the Nation-Building Project

    Directory of Open Access Journals (Sweden)

    Boris Michel

    2009-01-01

    Full Text Available Review of the monograph: Barr, Michael and Zlatko Skrbiš, Constructing Singapore. Elitism, Ethnicity and the Nation-Building Project, Copenhagen: NIAS Press, 2008, ISBN 978-87-7694-029-4, 304 pages

  14. Tandem Knoevenagel–Michael reactions in aqueous diethylamine medium: A greener and efficient approach toward bis-dimedone derivatives

    Directory of Open Access Journals (Sweden)

    Abdullah Mohammed Al-Majid

    2017-02-01

    The use of inexpensive, eco-friendly and readily available reagents, easy work-up, and high purity products makes the procedure a convenient and robust method for the synthesis of tandem Knoevenagel–Michael adducts.

  15. Michael T. Westrate. Living Soviet in Ukraine from Stalin to Maidan: Under the Falling Red Star in Kharkiv.

    Directory of Open Access Journals (Sweden)

    Charitie V. Hyman

    2017-09-01

    Full Text Available Book review of Michael T. Westrate. Living Soviet in Ukraine from Stalin to Maidan: Under the Falling Red Star in Kharkiv. Rowman & Littlefield, 2016. xx, 232 pp. Illustrations. Appendices. Bibliography. Index. $85.00, cloth.

  16. The big picture : What the Baltics may learn from Ireland's success story / Michael Bourke ; interv. Maris Biezaitis

    Index Scriptorium Estoniae

    Bourke, Michael

    2002-01-01

    Ilmunud ka: Baltiiskii kurss 2002/Zima/Vesna nr. 20 lk. 14-17. Iirimaa aukonsul Lätis, Michael Joseph Bourke arutleb Iirimaa majandusedu teemal ning pakub välja, mida Baltimaad saaksid sellest õppida. Tabel, diagramm. Lisa

  17. Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology

    DEFF Research Database (Denmark)

    Pors, Niels Ole

    2010-01-01

    Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology. Medford. Information Today. ASIS&T Monographs, 2009. 185 pages. $ 59.50. ISBN 978-1-57387-373-4......Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology. Medford. Information Today. ASIS&T Monographs, 2009. 185 pages. $ 59.50. ISBN 978-1-57387-373-4...

  18. Additive manufacturing.

    Science.gov (United States)

    Mumith, A; Thomas, M; Shah, Z; Coathup, M; Blunn, G

    2018-04-01

    Increasing innovation in rapid prototyping (RP) and additive manufacturing (AM), also known as 3D printing, is bringing about major changes in translational surgical research. This review describes the current position in the use of additive manufacturing in orthopaedic surgery. Cite this article: Bone Joint J 2018;100-B:455-60.

  19. Associations between ultrasound measures of abdominal fat distribution and indices of glucose metabolism in a population at high risk of type 2 diabetes: the ADDITION-PRO study.

    Directory of Open Access Journals (Sweden)

    Annelotte Philipsen

    Full Text Available Visceral adipose tissue measured by CT or MRI is strongly associated with an adverse metabolic risk profile. We assessed whether similar associations can be found with ultrasonography, by quantifying the strength of the relationship between different measures of obesity and indices of glucose metabolism in a population at high risk of type 2 diabetes.A cross-sectional analysis of 1342 participants of the ADDITION-PRO study. We measured visceral adipose tissue and subcutaneous adipose tissue with ultrasonography, anthropometrics and body fat percentage by bioelectrical impedance. Indices of glucose metabolism were derived from a three point oral glucose tolerance test. Linear regression of obesity measures on indices of glucose metabolism was performed.Mean age was 66.2 years, BMI 26.9kg/m2, subcutaneous adipose tissue 2.5cm and visceral adipose tissue 8.0cm. All measures of obesity were positively associated with indicators of glycaemia and inversely associated with indicators of insulin sensitivity. Associations were of equivalent magnitude except for subcutaneous adipose tissue and the visceral/subcutaneous adipose tissue ratio, which showed weaker associations. One standard deviation difference in BMI, visceral adipose tissue, waist circumference, waist/height ratio and body fat percentage corresponded approximately to 0.2mmol/l higher fasting glucose, 0.7mmol/l higher 2-hr glucose, 0.06-0.1% higher HbA1c, 30 % lower HOMA index of insulin sensitivity, 20% lower Gutt's index of insulin sensitivity, and 100 unit higher Stumvoll's index of beta-cell function. After adjustment for waist circumference visceral adipose tissue was still significantly associated with glucose intolerance and insulin resistance, whereas there was a trend towards inverse or no associations with subcutaneous adipose tissue. After adjustment, a 1cm increase in visceral adipose tissue was associated with ~5% lower insulin sensitivity (p≤0.0004 and ~0.18mmol/l higher 2-hr

  20. Additional recommendations to reduce sexual and drug abuse-related transmission of human T-lymphotropic virus type III/lymphadenopathy-associated virus.

    Science.gov (United States)

    1986-03-14

    Previous US Public Health Service recommendations pertaining to sexual, IV drug abuse, and perinatal transmission of human-T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) have been published. Reduction of sexual and IV transmission of HTLV-III/LAV should be enhanced by using available serologic tests to give asymptomatic, infected individuals in high-risk groups the opportunity to know their status so they can take appropriate steps to prevent the further transmission of this virus. Since the objective of these additional recommendations is to help interrupt transmission by encouraging testing and counseling among persons in high-risk groups, careful attention must be paid to maintaining confidentiality and to protecting records from any unauthorized disclosure. The ability of health departments to assure confidentiality, and the public confidence in that ability, are crucial to efforts to increase the number of persons requesting such testing and counseling. Persons at increased risk of HTLV-III/LAV infection include: homosexual and bisexual men; present or past IV drug abusers; persons with clinical or laboratory evidence of infection, such as those with signs or symptoms compatible with acquired immune deficiency syndrome (AIDS) or AIDS-related complex (ARC); persons born in countries where heterosexual transmission is thought to play a major role; male or female prostitutes and their sex partners; sex partners of infected persons or persons at increased risk; all persons with hemophilia who have received clotting-factor products; and newborn infants of high-risk or infected mothers. Recommendations include: community health education programs should be aimed at members of high-risk groups to increase knowledge of AIDS, to facilitate behavioral changes to reduce risks of HTLV-III/LAV infection, and encourage voluntary testing and counseling; counseling and voluntary serologic testing for HTLV-III/LAV should be routinely offered to

  1. Food additives

    Science.gov (United States)

    ... GO About MedlinePlus Site Map FAQs Customer Support Health Topics Drugs & Supplements Videos & Tools Español You Are Here: Home → Medical Encyclopedia → Food additives URL of this page: //medlineplus.gov/ency/article/ ...

  2. One-pot cascade michael.cyclization reactions of ο-hydroxycinnamaldehydes: Synthesis of functionalized 2,3-dihydrobenzofuranes

    International Nuclear Information System (INIS)

    Gwon, Sung Hyuk; Kim, Sunggon

    2012-01-01

    We described the cascade Michael.cyclization reaction of o-hydroxycinnamaldehydes with diethyl α-bromomalonate promoted by potassium carbonate. The reactions provided functionalized 2,3-dihydrobenzofurans in good yields for a variety of o-hydroxyaromatic α,β-unsaturated aldehydes. Current work focuses on expanding the scope of this reaction to other substrates such as sulfur yields, and on developing an efficient catalytic asymmetric variant. 2,3-Dihydrobenzofurans are found in numerous biologically active natural products and synthetic compounds. These are an attractive type of oxygenated compound because their basic core skeleton is present in neolignans, pterocarpans, and synthetic drugs used in the treatment of pulmonary hypertension, atherosclerotic peripheral arterial disease, and central nervous system trauma and ischemia. Owing to the importance of their structures, numerous synthetic methods for 2,3-dihydrobenzofurans have been developed, primarily: radical cyclizations, Lewis acid promoted reactions, anionic cyclizations, and transition-metal catalyzed processes. However, these methods cannot be generalized as much as is desirable, and they yielded poor chemo- and/or stereoselectivities. Hence, the development of an efficient enantioselective synthetic method for obtaining 2,3-dihydrobenzofuran scaffolds attracted our attention

  3. One-pot cascade michael.cyclization reactions of ο-hydroxycinnamaldehydes: Synthesis of functionalized 2,3-dihydrobenzofuranes

    Energy Technology Data Exchange (ETDEWEB)

    Gwon, Sung Hyuk; Kim, Sunggon [Kyonggi Univ., Suwon (Korea, Republic of)

    2012-04-15

    We described the cascade Michael.cyclization reaction of o-hydroxycinnamaldehydes with diethyl α-bromomalonate promoted by potassium carbonate. The reactions provided functionalized 2,3-dihydrobenzofurans in good yields for a variety of o-hydroxyaromatic α,β-unsaturated aldehydes. Current work focuses on expanding the scope of this reaction to other substrates such as sulfur yields, and on developing an efficient catalytic asymmetric variant. 2,3-Dihydrobenzofurans are found in numerous biologically active natural products and synthetic compounds. These are an attractive type of oxygenated compound because their basic core skeleton is present in neolignans, pterocarpans, and synthetic drugs used in the treatment of pulmonary hypertension, atherosclerotic peripheral arterial disease, and central nervous system trauma and ischemia. Owing to the importance of their structures, numerous synthetic methods for 2,3-dihydrobenzofurans have been developed, primarily: radical cyclizations, Lewis acid promoted reactions, anionic cyclizations, and transition-metal catalyzed processes. However, these methods cannot be generalized as much as is desirable, and they yielded poor chemo- and/or stereoselectivities. Hence, the development of an efficient enantioselective synthetic method for obtaining 2,3-dihydrobenzofuran scaffolds attracted our attention.

  4. Entrevista com Michael R. KatzDOI: 10.5007/2175-7968.2011v1n27p329

    Directory of Open Access Journals (Sweden)

    Maria Lúcia Barbosa de Vasconcellos

    2011-11-01

    Full Text Available Michael R. Katz graduated from Horace Mann School (New York and attended Williams College (Massachusetts, where he was the very first Russian major. Following graduation in 1966, he studied at Oxford University and the University of Leningrad, where he received his D.Phil. (or Ph.D. in Literature from Oxford. He first taught Russian at Williams and in 1984 became Chair of the Department of Slavic Language and Director of the Title VI Center for Russian and East European Studies at the University of Texas at Austin,. In 1998, he accepted a position as Dean of Language Schools and Schools Abroad at Middlebury College (Vermont. Since his term as Dean ended in 2004, he has been a full-time professor at the Russian Department. Prof. Katz has published several articles on literary translation and written two books. Additionally, he is a published translator of more than a dozen works into English, including novels by Herzen, Chernyshevsky, Dostoevsky, Turgenev, Tolstoy. In this interview, Katz explains how he became a translator, and addresses some important issues concerning the market for translation, his relationship with editors and publishing houses, translation and its critics, and some of the challenges he encountered translating from Russian into English.

  5. Compassionate leadership? Some reflections on the work and life of Michael Lapsley

    Directory of Open Access Journals (Sweden)

    Ian A. Nell

    2016-03-01

    Full Text Available In June 2007, I had the privilege of attending a Healing of Memories workshop lead by Father Michael Lapsley, one of the founder members of the Institute for Healing of Memories. The purpose of the workshop was to help the predominantly white members of a middle class Dutch Reformed congregation in the Northern Suburbs of Cape Town and the predominantly coloured members of a congregation of the Evangelical Lutheran Church in Elsies River on the Cape Flats, to share their stories of the past with regard to apartheid with each other. Apart from the stories that were told and the sharing of experiences about the apartheid history that took place, I was struck by the way in which Father Lapsley conducted the workshop. There was a deep compassion for all the participants as was embodied through the way in which he treated each of us with respect. But apart from his cordiality in leading the workshop, one could sense a deeper source of compassion, a source revealing a compassionate understanding of God�s presence amidst the violence and turmoil in our broken world. The aim of this article is to reflect on whether one could speak of something like �compassionate leadership�, and to take a closer look at the relationship between compassion and God images in the life and work of Michael Lapsley. Special attention will be given to the way in which he exercises leadership through his many involvements related to his own personal story of trauma.Intradisciplinary and/or interdisciplinary implications: This article presents literary research on the notion of compassionate leadership as a specific kind of leadership. The results indicate that the leadership of Father Michael Lapsley does indeed portray features of this kind of leadership. The research can become the source for finding new strategies for religious leadership.

  6. An Interview with Michael Betancourt, author of Agnotology & Crisis in Digital Capitalism

    OpenAIRE

    Sean Scanlan; Michael Betancourt

    2015-01-01

    Sean Scanlan, NANO's editor, interviews artist, curator, art historian and critical theorist Michael Betancourt to discuss the nature of agnotology, a term that means the “creation of uncertainty and ambivalent ‘fact’; it is a competitive tool incompatible with the idealized ‘free market’ of capitalism.” Betancourt is skeptical of Big Data and the ways that the consumers who unknowingly “produce” data for business interpretation are increasingly becoming transformed into a “token of exchange ...

  7. Athlete endorsement as a marketing strategy: a case study of Nike and Michael Jordan

    OpenAIRE

    Masár Vieites, Laura Virginia

    2014-01-01

    Les empreses intenten obrir mercats nous constantment, aconseguint atraure nous clients objectiu i augmentar el reconeixement de la marca. Aquest treball investiga el cóm i per què el patrocini d'atletes, per a que aquests representin els productes d'una empresa, ja que és una eina cada vegada més àmplia i popular en el màrqueting mix de les empreses. Michael Jordan, un estel retirada de bàsquet, ha rebut molta atenció dels mitjans publicitaris i ha representat sota patrocini a diversos produ...

  8. [The problem of evil in families--the filmmaker Michael Haneke].

    Science.gov (United States)

    Skårderud, Finn

    2010-09-23

    With the beautiful and dark film "The white ribbon", from 2009, the Austrian film director Michael Haneke consolidated his status as an international success. A central theme in his films is evilness and its roots. But just as important is his ambition to develop films where evil is not only portrayed, but where spectators are challenged to relate to their own ethical standards and their role as spectators. Haneke is a highly original filmmaker with his consistent search for a film aesthetic that stimulates ethical self-reflection and mentalizing. He partly succeeds in this quest.

  9. The Great War and All That in A Hundred Doors by Michael Longley

    Directory of Open Access Journals (Sweden)

    Elisabeth Delattre

    2015-03-01

    Full Text Available The Great War has featured regularly in Michael Longley’s poetry, for personal, family, aesthetic and political reasons. His collection published in 2011 under the title A Hundred Doors contains a number of poems relating to his father and the so-called War Poets, in connection with others in which love and nature, life and death are also dominant themes. This article will show how, as elsewhere in his poetry, everything is interrelated, “the nature poetry”, in Longley’s words, “fertilizing the war poetry”.

  10. European Management: an emerging competitive advantage of European nations: A reply to Michael Porter

    OpenAIRE

    Bosch, Frans; Prooijen, A.A.

    1992-01-01

    textabstractThis article extends the debate begun in the June 1992 issue of EMJ when the authors first criticized Michael Porter's explanatory framework in his Competitive Advantage of Nations (1990), over the role of national culture on the competitive advantage of nations. In this paper, Frans van den Bosch and Arno van Prooijen stress that Europe is a locus of competitive advantage if one is prepared to pay attention to the possibility of ‘European Management’ as a potential asset of Europ...

  11. POLYETHYLENEIMINE (PEI ON SILICA AS CATALYST IN KNOEVENAGEL AND MICHAEL REACTIONS

    Directory of Open Access Journals (Sweden)

    FATIHA ZAOUI

    2017-03-01

    Full Text Available After the synthesis of polyethylenimine supported on silica, it has been used as a new and efficient catalyst in Knoevenagel and Michael condensations. The presence of the polyethylenimine in the catalytic system together with silica displays an acido-basic character allows a better catalytic activity in the condensations. Carried out under microwave irradiation, without organic solvent and during short time, the syntheses are respectful towards green chemistry. The solid catalyst can be easily reused. This catalyst has the acido-basic character at the same time.

  12. LECTURE CANCELLED - “The power of collaboration - innovating collaborative relationships" by Michael Kimmel | 8 March

    CERN Multimedia

    2013-01-01

    PLEASE NOTE THAT THIS LECTURE IS CANCELLED Friday, 8 March -  from 11.30 a.m. to 1 p.m. Globe of Science and Innovation Route de Meyrin, 1211 Geneva International Women’s Day Conference Lecture will be in English - Interpreting available in French Limited number of seats - registration is essential Reservation: + 41 22 767 76 76 or cern.reception@cern.ch Dr. Michael Kimmel, a renowned sociologist and an expert on male-female relationships, will share his latest findings on gender collaboration and how it can lead to innovation and improved relationships both at work and in the world outside. Michael Kimmel is among the world’s leading experts on male-female relationships. A Professor of Sociology at the State University of New York at Stony Brook, he is the author or editor of more than 20 books on the topic. He consults corporations, NGOs and public sector organisations all over the world on gender equity issues, including work-family balance, reducing workplac...

  13. Michael Polanyi and his generation origins of the social construction of science

    CERN Document Server

    Nye, Mary Jo

    2011-01-01

    In Michael Polanyi and His Generation, Mary Jo Nye investigates the role that Michael Polanyi and several of his contemporaries played in the emergence of the social turn in the philosophy of science. This turn involved seeing science as a socially based enterprise that does not rely on empiricism and reason alone but on social communities, behavioral norms, and personal commitments. Nye argues that the roots of the social turn are to be found in the scientific culture and political events of Europe in the 1930s, when scientific intellectuals struggled to defend the universal status of scientific knowledge and to justify public support for science in an era of economic catastrophe, Stalinism and Fascism, and increased demands for applications of science to industry and social welfare. At the center of this struggle was Polanyi, who Nye contends was one of the first advocates of this new conception of science. Nye reconstructs Polanyi’s scientific and political milieus in Budapest, Berlin, and Manchester f...

  14. Adapting Shakespeare – Converting Shylock in Michael Radford’s the Merchant of Venice

    Directory of Open Access Journals (Sweden)

    Oakes Luke

    2016-08-01

    Full Text Available This article aims to explore the extension and evolution of Shakespeare’s The Merchant of Venice through Michael Radford’s 2004 cinematic adaptation. By investigating the concept of adaptation and the significance of intertextuality, Shakespeare’s source text is considered alongside Radford’s twenty-first century recreation to reimagine and redefine the construction of Shylock as both a comic and tragic device utilized across film and play. Issues of racial and religious prejudices alongside anti- Semitic views were particularly prominent in Elizabethan England and, by concentrating on recontextualisation, this article looks to expose Shakespeare’s characterization as a reflective commentary concerning societal discriminations at the time of the play’s performance. By focusing primarily on Shakespeare’s Jewish Usurer, Radford is able to reconstruct and reestablish the dramatic devices and characters within the cinematic version, metaphorically converting Shylock from comic villain to tragic victim. Finally, it argues that this dynamic shift inevitably metamorphoses Shylock from a spectator’s perspective and provides Michael Radford with an opportunity to offer a social commentary on social inequality in the twenty-first century.

  15. Insulin monotherapy compared with the addition of oral glucose-lowering agents to insulin for people with type 2 diabetes already on insulin therapy and inadequate glycaemic control

    NARCIS (Netherlands)

    Vos, Rimke C; van Avendonk, Mariëlle JP; Jansen, Hanneke; Goudswaard, Alexander N; van den Donk, Maureen; Gorter, Kees; Kerssen, Anneloes; Rutten, Guy EHM

    2016-01-01

    BACKGROUND: It is unclear whether people with type 2 diabetes mellitus on insulin monotherapy who do not achieve adequate glycaemic control should continue insulin as monotherapy or can benefit from adding oral glucose-lowering agents to the insulin therapy. OBJECTIVES: To assess the effects of

  16. Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk

    NARCIS (Netherlands)

    Hu, Xinli; Deutsch, Aaron J; Lenz, Tobias L; Onengut-Gumuscu, Suna; Han, Buhm; Chen, Wei-Min; Howson, Joanna M M; Todd, John A; de Bakker, Paul I W; Rich, Stephen S; Raychaudhuri, Soumya

    Variation in the human leukocyte antigen (HLA) genes accounts for one-half of the genetic risk in type 1 diabetes (T1D). Amino acid changes in the HLA-DR and HLA-DQ molecules mediate most of the risk, but extensive linkage disequilibrium complicates the localization of independent effects. Using

  17. Method for the determination of natural ester-type gum bases used as food additives via direct analysis of their constituent wax esters using high-temperature GC/MS

    Science.gov (United States)

    Tada, Atsuko; Ishizuki, Kyoko; Yamazaki, Takeshi; Sugimoto, Naoki; Akiyama, Hiroshi

    2014-01-01

    Natural ester-type gum bases, which are used worldwide as food additives, mainly consist of wax esters composed of long-chain fatty acids and long-chain fatty alcohols. There are many varieties of ester-type gum bases, and thus a useful method for their discrimination is needed in order to establish official specifications and manage their quality control. Herein is reported a rapid and simple method for the analysis of different ester-type gum bases used as food additives by high-temperature gas chromatography/mass spectrometry (GC/MS). With this method, the constituent wax esters in ester-type gum bases can be detected without hydrolysis and derivatization. The method was applied to the determination of 10 types of gum bases, including beeswax, carnauba wax, lanolin, and jojoba wax, and it was demonstrated that the gum bases derived from identical origins have specific and characteristic total ion chromatogram (TIC) patterns and ester compositions. Food additive gum bases were thus distinguished from one another based on their TIC patterns and then more clearly discriminated using simultaneous monitoring of the fragment ions corresponding to the fatty acid moieties of the individual molecular species of the wax esters. This direct high-temperature GC/MS method was shown to be very useful for the rapid and simple discrimination of varieties of ester-type gum bases used as food additives. PMID:25473499

  18. Method for the determination of natural ester-type gum bases used as food additives via direct analysis of their constituent wax esters using high-temperature GC/MS.

    Science.gov (United States)

    Tada, Atsuko; Ishizuki, Kyoko; Yamazaki, Takeshi; Sugimoto, Naoki; Akiyama, Hiroshi

    2014-07-01

    Natural ester-type gum bases, which are used worldwide as food additives, mainly consist of wax esters composed of long-chain fatty acids and long-chain fatty alcohols. There are many varieties of ester-type gum bases, and thus a useful method for their discrimination is needed in order to establish official specifications and manage their quality control. Herein is reported a rapid and simple method for the analysis of different ester-type gum bases used as food additives by high-temperature gas chromatography/mass spectrometry (GC/MS). With this method, the constituent wax esters in ester-type gum bases can be detected without hydrolysis and derivatization. The method was applied to the determination of 10 types of gum bases, including beeswax, carnauba wax, lanolin, and jojoba wax, and it was demonstrated that the gum bases derived from identical origins have specific and characteristic total ion chromatogram (TIC) patterns and ester compositions. Food additive gum bases were thus distinguished from one another based on their TIC patterns and then more clearly discriminated using simultaneous monitoring of the fragment ions corresponding to the fatty acid moieties of the individual molecular species of the wax esters. This direct high-temperature GC/MS method was shown to be very useful for the rapid and simple discrimination of varieties of ester-type gum bases used as food additives.

  19. Textural characteristics of ready-to-eat breakfast cereals produced from different types of cereal and with varying water addition during extrusion process

    Directory of Open Access Journals (Sweden)

    Žaneta Ugarčić-Hardi

    2010-01-01

    Full Text Available Textural characteristics of ready-to-eat breakfast cereals were evaluated in order to determine the influence of wheat, corn and rice flour, as well as a varying water addition during the extrusion process. Extruded breakfast cereal balls were made of wheat semolina in combination with wheat, corn or rice flour. Three different levels of water addition (21 %, 23 % and 27 % were used during the extrusion process. Samples were prepared with and without surface sugar coating. Sensory and instrumental assessments (TA.XT Plus were used to evaluate textural attributes of dry samples and samples during immersion in milk. Weibull equation was used for nonlinear estimation of experimental data obtained for milk absorption and crispiness as a function of time. Crispiness of dry extruded balls without coating was much higher than for samples with coating. The highest values for crispness were observed for wheat extruded balls and the lowest for samples with corn flour addition. Increasing water addition during the extrusion process significantly increased crispness of ready-to-eat breakfast cereals. The rate of milk absorption and loss of crispiness were significantly higher for samples without coating than for samples with coating.

  20. Different types of additional somatosensory information do not promote immediate benefits on gait in patients with Parkinson's disease and older adults

    Directory of Open Access Journals (Sweden)

    Ellen Lirani-Silva

    2015-09-01

    Full Text Available AbstractPlantar cutaneous stimulation has been shown to improve gait in Parkinson's disease (PD, but the effects of different types of insoles have not been tested. We evaluated the immediate effect of different types of insoles on gait in PD patients and healthy older adults. Nineteen PD patients and nineteen healthy older adults performed and performed a walking task at their self-selected speed in three conditions: conventional insole, insole with a raised ridge around the foot perimeter, and insole with half-spheres. Plantar sensation was evaluated before and after the walking protocol. There were no differences between groups for plantar sensation before and after the walking task. PD patients demonstrated reduced stride length and stride velocity. There were no immediate benefits offered by the insoles on gait of either group. The increased plantar cutaneous stimulation does not promote immediate benefits on gait in PD patients and healthy older adults.

  1. Effect of the addition of rosiglitazone to metformin or sulfonylureas versus metformin/sulfonylurea combination therapy on ambulatory blood pressure in people with type 2 diabetes

    DEFF Research Database (Denmark)

    Komajda, Michel; Curtis, Paula; Hanefeld, Markolf

    2008-01-01

    BACKGROUND: Hypertension and type 2 diabetes are common co-morbidities. Preliminary studies suggest that thiazolidinediones reduce blood pressure (BP). We therefore used ambulatory BP to quantify BP lowering at 6-12 months with rosiglitazone used in combination with metformin or sulfonylureas...... compared to metformin and sulfonylureas in people with type 2 diabetes. METHODS: Participants (n = 759) in the multicentre RECORD study were studied. Those taking metformin were randomized (open label) to add-on rosiglitazone or sulfonylureas, and those on sulfonylurea to add-on rosiglitazone or metformin....... RESULTS: 24-Hour ambulatory BP was measured at baseline, 6 months and 12 months. At 6 and 12 months, reductions in 24-hour ambulatory systolic BP (sBP) were greater with rosiglitazone versus metformin (difference at 6 months 2.7 [95% CI 0.5-4.9] mmHg, p = 0.015; 12 months 2.5 [95% CI 0.2-4.8] mmHg, p = 0...

  2. Efficacy and safety of teneligliptin in addition to insulin therapy in type 2 diabetes mellitus patients on hemodialysis evaluated by continuous glucose monitoring.

    Science.gov (United States)

    Yajima, Takahiro; Yajima, Kumiko; Hayashi, Makoto; Takahashi, Hiroshi; Yasuda, Keigo

    2016-12-01

    Appropriate glycemic control without hypoglycemia is important in patients with type 2 diabetes on hemodialysis. Teneligliptin, a novel dipeptidyl peptidase-4 inhibitor, can be used without dose adjustment for these patients. Using continuous glucose monitoring (CGM), we evaluated the efficacy and safety of adding teneligliptin to insulin therapy. Twenty-one type 2 diabetes mellitus patients on hemodialysis treated with insulin were enrolled. After the adjustment of insulin dose, their blood glucose level was monitored by CGM. Insulin dose was reduced after teneligliptin administration. The median total daily insulin dose significantly reduced from 18 (9-24)U to 6 (0-14)U (p1). Maximum, mean, and standard deviation of blood glucose level on the hemodialysis and non-hemodialysis days did not change after teneligliptin administration. However, minimum blood glucose level was significantly elevated on the hemodialysis day after teneligliptin administration (from 3.9±1.0mmol/L to 4.4±0.9mmol/L, p=0.040). The incidence of asymptomatic hypoglycemia on the hemodialysis day detected by CGM significantly decreased from 38.1% to 19.0% (p=0.049). Teneligliptin may contribute toward reducing the total daily insulin dose and preventing hypoglycemic events on the hemodialysis day in type 2 diabetes mellitus patients. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  3. Enhanced performance of starter lighting ignition type lead-acid batteries with carbon nanotubes as an additive to the active mass

    Science.gov (United States)

    Marom, Rotem; Ziv, Baruch; Banerjee, Anjan; Cahana, Beni; Luski, Shalom; Aurbach, Doron

    2015-11-01

    Addition of various carbon materials into lead-acid battery electrodes was studied and examined in order to enhance the power density, improve cycle life and stability of both negative and positive electrodes in lead acid batteries. High electrical-conductivity, high-aspect ratio, good mechanical properties and chemical stability of multi-wall carbon nanotubes (MWCNT, unmodified and mofified with carboxylic groups) position them as viable additives to enhance the electrodes' electrical conductivity, to mitigate the well-known sulfation failure mechanism and improve the physical integration of the electrodes. In this study, we investigated the incorporation-effect of carbon nanotubes (CNT) to the positive and the negative active materials in lead-acid battery prototypes in a configuration of flooded cells, as well as gelled cells. The cells were tested at 25% and 30% depth-of-discharge (DOD). The positive effect of the carbon nanotubes (CNT) utilization as additives to both positive and negative electrodes of lead-acid batteries was clearly demonstrated and is explained herein based on microscopic studies.

  4. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

    DEFF Research Database (Denmark)

    Zeggini, Eleftheria; Scott, Laura J; Saxena, Richa

    2008-01-01

    analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and approximately 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample......Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published...

  5. Determinants of incident distal sensorimotor polyneuropathy in a cohort with screen-detected type 2 diabetes followed for 13 years, the ADDITION Denmark study

    DEFF Research Database (Denmark)

    Andersen, Signe Toft; Witte, Daniel; Dalsgaard, Else-Marie

    .001 in a Students t-test). Conclusion This study demonstrates a fairly low cumulative incidence of DPN defined by the MNSI in people with screen-detected T2DM. Our study provides evidence that macrovascular disease, obesity and higher levels of methylglyoxal present at the time of diagnosis of T2DM are risk factors......Background and aims Distal sensorimotor polyneuropathy (DPN) is the most common complication of diabetes. Cross-sectional studies indicate that determinants beyond hyperglycemia, such as obesity, dyslipidemia and cardiovascular disease are important, particularly in type 2 diabetes (T2DM...

  6. Highly efficient and generalized asymmetric synthesis of quaternary stereogenic carbon-containing β-amino indanones/indanoles via Mannich-type additions between 1-indanones and N-tert-butanesulfinylketimines.

    Science.gov (United States)

    Wu, Lingmin; Xie, Chen; Mei, Haibo; Soloshonok, Vadim A; Han, Jianlin; Pan, Yi

    2014-07-14

    Here we report that, unlike other ketones, 1-indanone and acetophenone derived enolates undergo Mannich-type addition reactions with N-tert-butanesulfinyl ketimines with excellent yields (up to 98%) and diastereoselectivity (>99/1). The resulting compounds represent a new type of biologically relevant β-aminoketone derivative bearing quaternary stereogenic carbon, which could be further converted into the corresponding β-amino ketones and β-amino alcohols, possessing three consecutive stereogenic centres.

  7. An Interactive Signed Distance Approach for Multiple Criteria Group Decision-Making Based on Simple Additive Weighting Method with Incomplete Preference Information Defined by Interval Type-2 Fuzzy Sets

    OpenAIRE

    Ting-Yu Chen

    2014-01-01

    Interval type-2 fuzzy sets (T2FSs) with interval membership grades are suitable for dealing with imprecision or uncertainties in many real-world problems. In the Interval type-2 fuzzy context, the aim of this paper is to develop an interactive signed distance-based simple additive weighting (SAW) method for solving multiple criteria group decision-making problems with linguistic ratings and incomplete preference information. This paper first formulates a group decision-making problem with unc...

  8. Cuestión de tiempo: Michael Fried y el tiempo del arte moderno A matter of time: Michael Fried and modernist art the time of modernist art

    Directory of Open Access Journals (Sweden)

    David Díaz Soto

    2011-07-01

    Full Text Available En el siglo XIX, autores fundacionales del formalismo, como Fiedler o Hildebrand, contrapusieron estrictamente las artes plásticas, «puramente visuales», a las artes verbales del discurso, proscribiéndoles la narración y disociándolas de la temporalidad: se trata del «principio de exclusión del tiempo», vinculado al formalismo. Más tarde, el crítico «modernista» de arte Clement Greenberg planteó la instantaneidad, en tanto que opuesta a la duración, como modalidad ideal de la experiencia artística. Pero el historiador y crítico de arte Michael Fried, en sus textos de los años 60 sobre arte abstracto, se distancia de Greenberg, desarrollando un discurso sobre la temporalidad en las artes plásticas, con nociones como «tiempo visual»; y en sus posteriores textos historiográficos investiga las modalidades temporales de la representación pictórica. La aparente paradoja entre la crítica de Fried a la hipóstasis «literalista» de la duración en las tardovanguardias y el papel crucial que concede a Manet y a la instantaneidad en el origen del arte moderno, la resolveremos atendiendo a su reivindicación de la temporalidad durativa de «lo cotidiano». Así cabe comprender la concepción de la modalidad temporal característica de la modernidad y del arte moderno, a la que apunta su noción teórica de presentness.In the nineteenth century, seminal authors of Formalism, like Fiedler or Hildebrand, strictly compared the «purely visual» plastic arts to the discursive arts of verbal language, ruling out narrativity from plastic arts, which they dissociated from temporality - the formalist «principle of exclusion of time». Later on, «modernist» art critic Clement Greenberg claimed that instantaneousness, as opposed to duration, was the ideal modality for artistic experience. Art critic and historian Michael Fried did not share Greenberg's position, but developed instead a discourse about time in plastic arts. In his early

  9. Las relaciones entre la Iglesia y el Estado en la teoría de la justicia de Michael Walzer

    OpenAIRE

    Roldán, Alberto Fernando

    2009-01-01

    Roldan, A. F. (2009). Las relaciones entre la Iglesia y el Estado en la teoría de la justicia de Michael Walzer (Tesis de Maestría). Universidad Nacional de Quilmes, Bernal, Argentina. En la presente tesis, se discuten las relaciones entre la Iglesia –término que se utiliza no en el sentido confesional sino en tanto institución religiosa- y el Estado moderno. Se escoge como marco teórico la filosofía política del pensador judío americano Michael Walzer, exponente del “comunitarismo”, un...

  10. Rare Type of Course and Distribution of an Additional Right Hepatic Artery: A Possible Source of Iatrogenic Injury During Hepato-biliary and Pancreatic Surgeries

    Directory of Open Access Journals (Sweden)

    Prakashchandra Shetty

    2017-07-01

    Full Text Available Celiac artery shows frequent variations in its branching pattern. Knowledge of its possible variations is useful in gastric, pancreatic and hepato-biliary surgeries. During our dissection classes, we observed a rare variation of the branching pattern of celiac trunk. It divided normally into its three branches; left gastric, splenic and common hepatic arteries. Left gastric and splenic arteries were normal in their course and distribution. The common hepatic artery trifurcated to give hepatic artery proper, gastroduodenal artery and an additional right hepatic artery. The branching pattern of hepatic artery proper and gastroduodenal arteries was normal. The additional right hepatic artery gave origin to a right gastric artery and a large pancreatic branch to the head of the pancreas. It coursed parallel to the bile duct, being on its right side, passed through the Calot’s triangle and entered the right lobe of liver through the fossa for gall bladder. In the Calot’s triangle, it gave a cystic branch to the gall bladder. We discuss the clinical importance of this rare variation in this paper.

  11. Michael Fordham and the Journal of Analytical Psychology: the view from Hangman's Hill.

    Science.gov (United States)

    Urban, Elizabeth

    2015-09-01

    This short paper was presented to a conference in honour of the 60(th) year of the JAP and was one of others that acknowledged the contribution of Michael Fordham. The subtitle refers to the paper's overview of Fordham's published oeuvre and the particular place of the Journal of Analytical Psychology, for which he was the founding editor. Fordham's contribution to a Jungian-based model of development is discussed, with reference to his papers in the British Journal of Medical Psychology. The paper notes miscellaneous pieces from Fordham's commentaries, obituaries, papers and reviews which capture not only the development of Fordham as a thinker but also his character. There is discussion of his reviews of Melanie Klein's Envy and Gratitude and manuscripts by Erich Neumann. A reminiscence of Fordham as supervisor is recounted. © 2015, The Society of Analytical Psychology.

  12. Lizards, ticks and contributions to Australian parasitology: C. Michael Bull (1947-2016).

    Science.gov (United States)

    Godfrey, Stephanie S; Gardner, Michael G

    2017-12-01

    Professor C. Michael Bull was a great scientist and mentor, and an Associate Editor of this journal. While his research career spanned the fields of behavioural ecology, conservation biology and herpetology, in this article, we pay tribute to his major contribution to Australian parasitology. Mike authored more than eighty articles on host-parasite ecology, and revealed major insights into the biology and ecology of ticks from his long term study of the parapatric boundary of two tick species ( Amblyomma limbatum and Bothriocroton hydrosauri ) on the sleepy lizard ( Tiliqua rugosa ). In this article, we provide an overview of how this research journey developed to become one of the longest-running studies of lizards and their ticks, totalling 35 years of continuous surveys of ticks on lizards, and the insights and knowledge that he generated along that journey.

  13. A History of Experiences and Thinking Men. The History of Political Thought according to Michael Oakeshott

    Directory of Open Access Journals (Sweden)

    Spartaco Pupo

    2014-12-01

    Full Text Available Michael Oakeshott conceives the history of European political thought as a structuring of ideas and arguments of the practical experience aimed to understanding political expressions in vogue in the culture of a people. It is not a continuous and cumulative history of abstract and disembodied ideas, as it is wrongly conceived, but of some men who thought politics in a certain way on the basis of the language and of the set of actions, moral beliefs and contingencies of the people which they belong to. The article highlights the comparison between Oakeshott, Quentin Skinner and Gianfranco Miglio on the search for the most appropriate method to be applied in the study of the history of political thought.

  14. 'Introducing Michael Gove to Loïc Wacquant': Why Social Work Needs Critical Sociology.

    Science.gov (United States)

    Michael Garrett, Paul

    2016-06-01

    In 2013, Michael Gove, then Secretary of State for Education and Health in the UK coalition government, criticised social workers for laying insufficient emphasis on the 'agency' of individuals and for being too preoccupied with social and economic inequalities. Such a perspective, which is not unique to Gove, needs to be countered by reaffirming the significance of an expansively critical sociology for social work. In this context, the thematic concerns of the French theorist, Loïc Wacquant, illuminates key aspects of social work engagement with clients which Gove and his ideological associates appear intent on ignoring. The issues raised have significant political resonances given the pending UK General Election taking place in May 2015.

  15. Modalities of representation and perception in Michael Ondaatje’s Anil’s Ghost

    Directory of Open Access Journals (Sweden)

    Sigrid Renaux

    2017-01-01

    Full Text Available http://dx.doi.org/10.5007/2175-8026.2017v70n1p113 This study analyses the way in which the interdependence of the representation and perception of reality is exemplified and questioned in Michael Ondaatje’s Anil’s Ghost (2000. As we enter this work of resistance literature by way of an omniscient narrator, we enter not just the geographical spaces and cultural history of Sri Lanka, but find ourselves taking part in the daily struggle of the people to survive, to identify and do justice to the many dead in this conflict between ethnic groups and the government. This fragmentation of the narrative structure – casting doubt on the conflicting relationships established between the characters’ present and the past, between western and eastern values in relation to the concept of truth, the search for lost identity and love – highlights still further the interchangeability of representation and perception of reality.

  16. Michael Oakeshott´s Work as a Liberal-Conserv ative Paradigm

    Directory of Open Access Journals (Sweden)

    Josep Baqués

    2014-01-01

    Full Text Available As is the case with other thinkers linked to what can be broadly defined as conservatism, it is arguable whether Michael Oakeshott was just a conservative, or whether he was also a liberal. He often rejected this last label. He also tried to avoid the classic debate between the left/right wing divide, conferring instead a mantle of neutrality on his work. This analysis shows, on the one hand, that Oakeshott´s work is ideologically orientated and, on the other hand, that it contains a substantial liberal component. In fact, he offered a liberal-conservative synthesis in which the free market appears to be not only the best, but the only feasible outcome in the proposed scenario of political prudence. I will fi rst connect Oakeshott with the main traditions of thought, then analyse the theoretical implications of his position, and finally explore the consequences derived from all this for everyday political practice.

  17. The role of Michael Pupin in solving of Serbian national question

    Directory of Open Access Journals (Sweden)

    Grčić Mirko D.

    2004-01-01

    Full Text Available Michael I. Pupin was a professor at the University of Columbia, member and the president of Academy of Science in New York; one of the esteemed members of USA National Academy of Science; member and president of many experts and scientific institutions and societies in the USA; member of State Council for Scientific Research by president of the USA during the World War I. Of the great importance for political geography and geopolitics was his activity in Paris during the Peace Conference after the World War I in 1919 also as his great contribution to establishment of state borders of Kingdom of Serbs, Croats and Slovenians (later Yugoslavia, which helped those nations to establish their national borders at maximum level. Pupin claimed that he was Yugoslav patriot and American citizen. Role of M. Pupin in battle for national interests and Yugoslav borders after the World War I is shown in this article.

  18. Rationalism and traditionalism in politics. The correspondence between Karl R. Popper and Michael Oakeshott

    Directory of Open Access Journals (Sweden)

    Spartaco Pupo

    2016-07-01

    Full Text Available The correspondence of 1948 between Karl Popper and Michael Oakeshott, translated for the first time in Italian and published in the appendix to this paper, demonstrates the existence of two different ways of thinking about politics: the rationalist approach, founded on the “argumentation” as a rational means for the non-violent solution of problems (Popper, and the traditionalist mode, inspired by the method of “conversation” as a guarantee of constant openness to the diversity of identities (Oakeshott. To rise from the letters is a mutual influence on the interpretation of the key concepts that characterize the thought of the two authors, which however does not cancel the fundamental divergence of their political orientation.

  19. Highly scalable 3-D NAND-NOR hybrid-type dual bit per cell flash memory devices with an additional cut-off gate

    International Nuclear Information System (INIS)

    Cho, Seongjae; Shim, Wonbo; Park, Ilhan; Kim, Yoon; Park, Byunggook

    2010-01-01

    In this work, a nonvolatile memory (NVM) device of novel structure in 3 dimensions is introduced, and its operation physics is validated. It is based on a pillar structure in which two identical storage nodes are located for dual-bit operation. The two storage nodes on neighboring pillars are controlled by using one common control gate so that the space between silicon pillars can be further reduced. For compatibility with conventional memory operations, an additional cut-off gate is constructed under the common control gate. This is considered as the ultimate form for a 3-D nonvolatile memory device based on a double-gate structure. The underlying physics is explained, and the operational schemes are validated in various aspects by using a numerical device simulation. Also, critical issues in device design for higher reliability are discussed.

  20. Effect of cold work on CO sub 2 corrosion behavior of 13% Cr (420 type) stainless steel in brine medium with and without addition of sodium sulphide

    International Nuclear Information System (INIS)

    Akram Ali Agil; Azmi Rahmat; Suraj Bhan

    1996-01-01

    Cold work introduces residual stresses and increases internal stored energy. Plastic deformation also causes slip steps on the surface. All these factors effect corrosion rate as corrosion is controlled by surface reaction. The residual stresses are caused by inhomogeneous deformation in cold rolling and are maximum at low deformation and then decrease as the samples get thinner on further rolling. In the absence of CO sub 2 the corrosion rates are found relatively low in brine solution with or without addition of Na sub 2 S, with only slight variation with % total deformation. However simultaneous presence of CO sub 2 and Na sub 2 S has synergic effect increasing the corrosion rate appreciably. Presence of sulphur is also found to increase the pitting tendency in the steel

  1. Complete reversal of muscle wasting in experimental cancer cachexia: Additive effects of activin type II receptor inhibition and β-2 agonist.

    Science.gov (United States)

    Toledo, Míriam; Busquets, Sílvia; Penna, Fabio; Zhou, Xiaolan; Marmonti, Enrica; Betancourt, Angelica; Massa, David; López-Soriano, Francisco J; Han, H Q; Argilés, Josep M

    2016-04-15

    Formoterol is a highly potent β2-adrenoceptor-selective agonist, which is a muscle growth promoter in many animal species. Myostatin/activin inhibition reverses skeletal muscle loss and prolongs survival of tumor-bearing animals. The aim of this investigation was to evaluate the effects of a combination of the soluble myostatin receptor ActRIIB (sActRIIB) and the β2-agonist formoterol in the cachectic Lewis lung carcinoma model. The combination of formoterol and sActRIIB was extremely effective in reversing muscle wasting associated with experimental cancer cachexia in mice. Muscle weights from tumor-bearing animals were completely recovered following treatment and this was also reflected in the measured grip strength. This combination increased food intake in both control and tumor-bearing animals. The double treatment also prolonged survival significantly without affecting the weight and growth of the primary tumor. In addition, it significantly reduced the number of metastasis. Concerning the mechanisms for the preservation of muscle mass during cachexia, the effects of formoterol and sActRIIB seemed to be additive, since formoterol reduced the rate of protein degradation (as measured in vitro as tyrosine release, using incubated isolated individual muscles) while sActRIIB only affected protein synthesis (as measured in vivo using tritiated phenylalanine). Formoterol also increased the rate of protein synthesis and this seemed to be favored by the presence of sActRIIB. Combining formoterol and sActRIIB seemed to be a very promising treatment for experimental cancer cachexia. Further studies in human patients are necessary and may lead to a highly effective treatment option for muscle wasting associated with cancer. © 2015 UICC.

  2. ESR studies of Bunsen-type methane-air flames. II. The effects of the addition of halogenated compounds to the secondary air on the hydrogen atoms in the flame

    Energy Technology Data Exchange (ETDEWEB)

    Noda, S; Fujimoto, S; Claesson, O; Yoshida, H

    1983-09-01

    Hydrogen atoms in a methane-air Bunsen-type flame were detected by the flame-in-cavity ESR method. The addition of a halogenated compound to the secondary air reduced the H-atom concentration linearly with an increase in additive concentration. These 8 halogenated compounds examined showed increased effectiveness in scavenging H atoms in this order: hydrochloric acid < dichlorodifluoromethane < chloroform < methyl chloride < methylene chloride < trichlorofluoromethane < carbon tetrachlorie < methyl bromide. The chemical effects of these additives on the combustion reactions agree well with the inhibitor indices for these compounds. 14 references, 3 figures.

  3. "Alarme de incêndio": Michael Löwy e a crítica ecossocialista da civilização capitalista moderna "Fire alarm": Michael Löwy and the ecosocialist critique of the modern capitalist civilization

    Directory of Open Access Journals (Sweden)

    Fabio Mascaro Querido

    2013-04-01

    Full Text Available A emergência da crise ecológica, como sintoma mais nítido de uma verdadeira crise civilizató-ria, impôs novos desafios ao pensamento crítico e, em especial, ao marxismo. Partindo desse pressuposto, o objetivo deste artigo é apresentar a defesa de Michael Löwy de uma radicalização ecossocialista da crítica marxista da modernidade, tarefa para a qual a grande recusa de Walter Benjamin das ideologias do pro- gresso é uma das fontes decisivas de inspiração. Para Michael Löwy, a ruptura com as ideologias do progresso e com o paradigma civilizatório capitalista moderno é uma condição indispensável para a atua-lização ecossocialista do marxismo.The emergence of the ecological crisis as a clearer symptom of a true civilizatory crisis has imposed new challenges to critical thought and, in particular, to Marxism. Based on this assumption, this article aims to present Michael Löwy's defense of an ecosocialist radicalization of the Marxist critique of modernity, a task for which Walter Benjamin's great refusal of the ideologies of progress is one of the critical sources of inspiration. To Michael Löwy, breaking away from the ideologies of progress and from the modern capitalistic civilizatory paradigm is a prerequisite for the ecosocialist updating of Marxism.

  4. Synthesis and characterization of an additive type super plasticizers obtained from plastics cups of polystyrene; Sintese e caracterizacao de um aditivo tipo superplastificantes obtido a partir de copos plasticos de poliestireno

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, Carolina G.L.; Freire, Carolina B.; Tello, Cledola C. de O., E-mail: carolina_gabriela316@yahoo.com.br, E-mail: cbf@cdtn.br, E-mail: tellocc@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-BH), Belo Horizonte, MG (Brazil)

    2013-07-01

    This paper aims to describe the synthesis of an additive type superplasticizer from alternative material - plastic cups used of polystyrene - and characterize it physically and chemically in order to verify their efficiency and compare it with a commercial use superplasticizer. Following the search, the synthesized superplasticizer is used in mortars to assess their efficiency.

  5. Cost-effectiveness of intensive multifactorial treatment compared with routine care for individuals with screen-detected Type 2 diabetes : analysis of the ADDITION-UK cluster-randomized controlled trial

    NARCIS (Netherlands)

    Tao, L.; Wilson, E. C. F.; Wareham, N. J.; Sandbaek, A.; Rutten, G. E. H. M.; Lauritzen, T.; Khunti, K.; Davies, M. J.; Borch-Johnsen, K.; Griffin, S. J.; Simmons, R. K.

    Aims To examine the short- and long-term cost-effectiveness of intensive multifactorial treatment compared with routine care among people with screen-detected Type 2 diabetes. Methods Cost-utility analysis in ADDITION-UK, a cluster-randomized controlled trial of early intensive treatment in people

  6. Tensile strength and creep behaviour of austenitic stainless steel type 18Cr - 12Ni with niobium additions at 700{sup 0}C

    Energy Technology Data Exchange (ETDEWEB)

    Sordi, V L; Bueno, L O, E-mail: sordi@ufscar.b [Federal University of Sao Carlos, Materials Engineering Department, Sao Carlos (SP), 13565-905 (Brazil)

    2010-07-01

    The effect of niobium additions up to 2.36 wt% on the creep behavior of a series of seven extra low carbon 18Cr-12Ni austenitic stainless steels at 700{sup 0}C has been investigated. Grain size and hardness measurements, hot tensile tests and constant stress creep tests from 90 to 180 MPa were carried out for each alloy, in the solution treated condition at 1050, 1200 and 1300{sup 0}C followed by quench in water. The mechanical behavior at high temperature was related to the amount of NbC precipitation occurring during the tests. Solid solution and intermetallic compound effects were also considered. Creep data analysis was done to determine the parameters of the creep power-law equation {epsilon}-dot = A.{sigma}{sup n} and the Monkman-Grant relation {epsilon}-dot .t{sup m}{sub R} = K. Niobium-carbide precipitation in these steels reduces the secondary stage dependence of strain rate with applied stress, resulting in n-values which indicate the possibility of operation of various creep mechanisms. The creep strength during the secondary stage is primarily controlled by the amount of NbC available for precipitation. However, the rupture times increase progressively with niobium content, as the amount of undissolved carbide particles in grain boundaries and the Laves phase precipitation increase.

  7. Tensile strength and creep behaviour of austenitic stainless steel type 18Cr - 12Ni with niobium additions at 700°C

    Science.gov (United States)

    Sordi, V. L.; Bueno, L. O.

    2010-07-01

    The effect of niobium additions up to 2.36 wt% on the creep behavior of a series of seven extra low carbon 18Cr-12Ni austenitic stainless steels at 700°C has been investigated. Grain size and hardness measurements, hot tensile tests and constant stress creep tests from 90 to 180 MPa were carried out for each alloy, in the solution treated condition at 1050, 1200 and 1300°C followed by quench in water. The mechanical behavior at high temperature was related to the amount of NbC precipitation occurring during the tests. Solid solution and intermetallic compound effects were also considered. Creep data analysis was done to determine the parameters of the creep power-law equation dot epsilon = A.σn and the Monkman-Grant relation dot epsilon.tmR = K. Niobium-carbide precipitation in these steels reduces the secondary stage dependence of strain rate with applied stress, resulting in n-values which indicate the possibility of operation of various creep mechanisms. The creep strength during the secondary stage is primarily controlled by the amount of NbC available for precipitation. However, the rupture times increase progressively with niobium content, as the amount of undissolved carbide particles in grain boundaries and the Laves phase precipitation increase.

  8. Construction of bis-, tris- and tetrahydrazones by addition of azoalkenes to amines and ammonia

    Directory of Open Access Journals (Sweden)

    Artem N. Semakin

    2016-11-01

    Full Text Available Exhaustive Michael-type alkylations of amines and ammonia with azoalkenes (generated from α-halohydrazones were demonstrated as an efficient approach to poly(hydrazonomethylamines – a novel class of polynitrogen ligands. An intramolecular cyclotrimerization of C=N bonds in tris(hydrazonomethylamine to the respective 1,4,6,10-tetraazaadamantane derivative was demonstrated.

  9. N-Heterocyclic-Carbene-Catalysed Diastereoselective Vinylogous Mukaiyama/Michael Reaction of 2-(Trimethylsilyloxy)furan and Enones

    KAUST Repository

    Wang, Ying; Du, Guang Fen; Xing, Fen; Huang, Kuo-Wei; Dai, Bin; He, Lin

    2015-01-01

    N-heterocyclic carbenes have been utilised as highly efficient nucleophilic organocatalysts to mediate vinylogous Mukaiyama/Michael reactions of 2-(trimethylsilyloxy)furan with enones to afford γ-substituted butenolides in 44-99% yield with 3:1-32:1 diastereoselectivity. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Komparativistlikke ja kultuuriteaduslikke ärgitusi Baltimaade germanistikale / Michael Schwidtal ; saksa keelest tõlkinud Vahur Aabrams

    Index Scriptorium Estoniae

    Schwidtal, Michael

    2001-01-01

    3. - 5. sept. 2001 toimus Riias sümpoosion "Unter diesem braunen Himmel. Jakob Michael Reinhold Lenz und die deutsche Literatur des Baltikums", 7. - 9. sept. Tartus "Torm ja tung Liivimaal. Mässu mudelid", pühendatud J. M. R. Lenzi ja Kristian Jaak Petersoni loomingule. Ülevaade

  11. A Symposium on the Relevance of Michael Polanyi's Insights to a Reformulated Understanding of Science, Technology, and Society

    Science.gov (United States)

    Mead, Walter B.

    2011-01-01

    This is intended as an introductory statement to the explorations undertaken in the essays that follow. The authors of these essays attempt to introduce the reader to some of the insights of Michael Polanyi and their implications for the reader who wishes to come to a greater understanding of modern technological society, which--for better or…

  12. Jack Michael's Musings on the 60th Anniversary of Skinner's "Verbal Behavior"

    Science.gov (United States)

    Esch, Barbara E.; Esch, John W.; Palmer, David C.

    2017-01-01

    When the B. F. Skinner Foundation reprinted Skinner's "Verbal Behavior" in 1992, Jack Michael wrote one of its two forewords, a detailed outline of the book's purpose and scope. On the 60th anniversary of the first publication (1957) of "Verbal Behavior", Jack reflects on the book's impact and its importance to the…

  13. What I Think I May Have Learned--Reflections on 50 Years of Teaching: An Interview with Michael Wertheimer

    Science.gov (United States)

    Michael, Kurt D.

    2006-01-01

    Kurt Michael is an associate professor in the Department of Psychology at Appalachian State University (ASU) where he teaches history and systems of psychology, abnormal psychology, child psychopathology, and interventions for children and adolescents. He received his BA (cum laude) from the University of Colorado at Boulder and his MS and PhD in…

  14. Effective Integration of Technology and Instruction. Q&A with Michael Jay. REL Mid-Atlantic Educator Effectiveness Webinar Series

    Science.gov (United States)

    Regional Educational Laboratory Mid-Atlantic, 2015

    2015-01-01

    In this webinar, long-time educator and developer of education technology Michael Jay discussed the importance of using technology to support learning and gave examples of how teachers can integrate technology into their instruction based on the Common Core State Standards and the Next Generation Science Standards. The PowerPoint presentation and…

  15. N-Heterocyclic-Carbene-Catalysed Diastereoselective Vinylogous Mukaiyama/Michael Reaction of 2-(Trimethylsilyloxy)furan and Enones

    KAUST Repository

    Wang, Ying

    2015-10-15

    N-heterocyclic carbenes have been utilised as highly efficient nucleophilic organocatalysts to mediate vinylogous Mukaiyama/Michael reactions of 2-(trimethylsilyloxy)furan with enones to afford γ-substituted butenolides in 44-99% yield with 3:1-32:1 diastereoselectivity. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Progress in ultrasonic spray pyrolysis for condensed matter sciences developed from ultrasonic nebulization theories since Michael Faraday

    CSIR Research Space (South Africa)

    Mwakikunga, BW

    2014-01-01

    Full Text Available This review outlines, in great detail, the history of the phenomenon of ultrasonic nebulization of liquids since the discovery of such an effect by Michael Faraday and the explanation of the phenomenon by capillary wave mechanism and “cavitation...

  17. Jack Michael's Appointments at the University of Houston and Arizona State University: Reflections from a Former Student

    Science.gov (United States)

    Mabry, John H.

    2016-01-01

    Jack Michael was an early enthusiast for what is now called applied behavior analysis. His many seminal contributions were through early publications in applied behavior analysis and the work of the students he trained (e.g., T. Ayllon, M. M. Wolf). His close mentorship of students earned him acclaim as a teacher along with his many theoretical…

  18. Thomas DaCosta Kaufmann and Michael North (eds., Mediating Netherlandish Art and Material Culture in Asia

    Directory of Open Access Journals (Sweden)

    Claartje Rasterhoff

    2015-12-01

    Full Text Available Book notice of: Thomas DaCosta Kaufmann and Michael North (eds., Mediating Netherlandish Art and Material Culture in Asia (Amsterdam Studies in the Dutch Golden Age Amsterdam, Amsterdam University Press, 2014. 348 pp. ISBN 978-90-8964-569-2. € 99,00.

  19. Der Wert von Worten. Michael Serrer aus dem Literaturbüro Düsseldorf im Interview mit der Textpraxis-Redaktion

    Directory of Open Access Journals (Sweden)

    Michael Serrer

    2014-11-01

    Full Text Available Die Textpraxis-Redaktion unterhält sich mit Michael Serrer über Literaturvermittlung in Zeiten der Digitalisierung, über Kanonisierung und die Rolle der Literatur in der Gesellschaft. Michael Serrer ist Leiter des Literaturbüros NRW und Feuilletonist.

  20. Book Review: America’s Blind Spot: Chávez, Oil and US Security by Andrés Cala and Michael Economides

    DEFF Research Database (Denmark)

    Boscan, Luis

    2014-01-01

    Review of: America’s Blind Spot: Chávez, Oil and US Security. Andrés Cala and Michael Economides. Continuum Books. 2012.......Review of: America’s Blind Spot: Chávez, Oil and US Security. Andrés Cala and Michael Economides. Continuum Books. 2012....

  1. Examination and comparative study of the Ascension of The Prophet of Islam In The View Of Michael Sells And Anne-mari e Shamil with Inter- Religious Attitude

    Directory of Open Access Journals (Sweden)

    Mahdi Azadi

    2015-09-01

    Full Text Available Michael Sells, American scholar of Quran,about the Ascension (Mi,raj of the prophet (PBUH focuses on three issues: First, the Mi,raj term is not used in the Quran and the ascension of the explanation is not enough. second, Mohammad is no different from the miracle of the Quran is the miracle of God,he is not anything else, Quran states. Third, Ascension of the prophet (PBUH has been in sleep and dream.According to him, the discussion about the layers of the subject is based mainly on the evidence of Quran.In this case, only limited information can be found in the Asra chapter (sooreh of the Quran.In addition, he has tried to make the Ascension event from Jewish traditions and the effects Bvdaysm.actually the orientalist`s goal is to prove the absence of ascension of the prophet(PBUH.  In contrast, Anne-marie Shamil stayes that prophet`s ascension derived from the first verse of Asra sura and believes that two processes(horizontal and verticalfor prophet happened.and unlike Michael,he knows mi,raj from the God miracles.Anne-Marie because her sufficient the Sunni sources is doubt with belief in the physical and spiritual ascension,in some of her votes,such as; visible or not visible in the ascension of God by the prophet.Despite the fundamental criticism that some elements of the theory of two Orientalists arrived,positive points are observed in their ideas.in this article we have tried to express the views of the Orientalists, then to review their ideas considered

  2. Additives in yoghurt production

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    Milna Tudor

    2008-02-01

    Full Text Available In yoghurt production, mainly because of sensory characteristics, different types of additives are used. Each group, and also each substance from the same group has different characteristics and properties. For that reason, for improvement of yoghurt sensory characteristics apart from addition selection, the quantity of the additive is very important. The same substance added in optimal amount improves yoghurt sensory attributes, but too small or too big addition can reduce yoghurt sensory attributes. In this paper, characteristics and properties of mostly used additives in yoghurt production are described; skimmed milk powder, whey powder, concentrated whey powder, sugars and artificial sweeteners, fruits, stabilizers, casein powder, inulin and vitamins. Also the impact of each additive on sensory and physical properties of yoghurt, syneresis and viscosity, are described, depending on used amount added in yoghurt production.

  3. Entrevista com Mathieu Dosse, Gian Luigi de Rosa e Michael Kegler

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    Andréia Guerini

    2017-09-01

    Full Text Available O conjunto das três entrevistas que seguem aborda a mesma temática, isto é, aspectos de tradução/adaptação em geral e da tradução do romance Estive em Lisboa e lembrei de você de Luiz Ruffato em particular. O romance de Ruffato foi escrito em 2009, editado em Portugal (Quetzal, 2010 e traduzido para diferentes línguas, como italiano (La Nuova Frontiera, 2011, espanhol (Eterna Cadencia, 2011, francês (Chandeigne, 2015, alemão (Assoziation A, 2016 e, nos próximos meses será publicado em finlandês (Into. O livro foi adaptado para o cinema em 2015, pelo cineasta português José Barahona, sendo exibido em festivais nacionais e internacionais. As entrevistas abaixo foram feitas com os tradutores Gian Luigi De Rosa, Mathieu Dosse e Michael Kegler em 2016. Gian Luigi De Rosa (Itália/1969-- possui doutorado em “Culture e Istituzioni dei paesi di lingue iberiche in età moderna e contemporanea” e é professor de português na Universidade do Salento, em Lecce. É autor de livros e ensaios sobre língua e linguística portuguesa, literatura portuguesa e brasileira e tradução audiovisual e intersemiótica. É também responsável pela elaboração das legendas em italiano do filme Estive em Lisboa e lembrei de você. Mathieu Dosse (Brasil/1978-- é formado pela Université Paris 8, onde estudou Teoria da Tradução. Traduziu para o francês Graciliano Ramos, Luiz Ruffato e João Guimarães Rosa. Michael Kegler (Alemanha/1967-- estudou literatura brasileira e portuguesa na universidade de Frankfurt, sem concluir o curso. Trabalhou como livreiro no Centro do Livro de Língua Portuguesa, antes de se tornar tradutor literário. Traduziu para o alemão José Eduardo Agualusa, Moacyr Scliar, Luiz Ruffato, entre outros autores. Em julho de 2016, junto com Ruffato, recebeu o prêmio literário Hermann Hesse na Alemanha, pela qualidade da obra publicada em conjunto com a sua tradução.

  4. An Oral History Interview with MICHAEL M. CERNEA (interviewer: Judith Freidenberg

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    MICHAEL M. CERNEA

    2008-01-01

    Full Text Available The editors and editorial board of Human Organization are pleased to introduce readers to the following oral history interview with Michael M. Cernea, a development social scientist who has militated throughout his academic career and applied work for "putting people first", in the forefront of development projects and policies. Working for a long time for the promotion of anthropological and sociological knowledge, either in the activities of the World Bank or in the policies and programs of governments of both developed and developing countries, Dr. Cernea cleared pathways for applied social science that are sure to benefit people in development settings for many years to come. Undoubtedly many readers already know Dr. Cernea's work well, especially those of us who teach the anthropology of development or work in applied settings and organizations, but this interview embeds his broad body of work into a personal, human, and at times tragic context that opens with brushes with death, Nazi brutality, and exile. It also provides valuable insights for carrying out the work of development anthropologists within large-scale organizations and governments.This interview with Dr. Cernea was conducted by Dr. Judith Freidenberg, of the University of Maryland, on June 30, 2003, for the Society for Applied Anthropology Oral History Project, headquartered at the University of Kentucky Libraries. This Project aims to create, through the vehicle of oral histories, a record of the life, activities and experiences of number of selected scholars-anthropologists who devoted a great part of their scientific work to research, to applied work in different settings, to inducing development, including to hands-on work on crafting public social policies and actual development programs. The present transcript of the interview was reviewed by both participants for editorial purposes. Michael M. Cernea expanded some of his oral responses, for historical accuracy or to add

  5. Ecossocialismo, romantismo e (autocrítica da modernidade em Michael Löwy

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    Fabio Mascaro Querido

    2008-12-01

    Full Text Available Partindo da concreticidade da crise ecológica e das transformações contemporâneas no âmbito dos processos de acumulação capitalista, o objetivo geral deste artigo é versar algumas notas preliminares a propósito da perspectiva teórica e política do assim chamado ecossocialismo, tal qual formulado em Michael Löwy. “Corrente de pensamento e de ação” cuja resposta à crise ecológica, a um só tempo romântica e socialista, constitui igualmente uma crítica às potencialidades destrutivas contidas no interior do paradigma societário e produtivo da modernidade. Neste trajeto, busca -se uma aproximação à apropriação löwiniana da obra de Walter Benjamin, especialmente de sua crítica do “progresso” moderno e das ideologias apologetas da “modernização”. Almeja -se assim antever a forma através da qual Michael Löwy e os ecossocialistas respondem às profundas transformações da (pós modernidade capitalista contemporânea, com ênfase particular sobre um argumento central projetado na obra do intelectual franco -brasileiro, qual seja: a defesa da necessidade de que o marxismo radicalize “sua crítica da modernidade, do paradigma da civilização ocidental, industrial, moderna, burguesa” (LÖWY, 2000c, p.242, argumento que o levaria, já em meados da década de 1980, a valorizar as potencialidades revolucionárias subjacentes a crítica romântica da modernidade. Por fim, indaga -se sobre a projeção ecossocialista da necessidade de superação revolucionária do paradigma civilizatório propalado pelo capitalismo moderno

  6. Synthesis of purines bearing functionalized C-substituents by the conjugate addition of nucleophiles to 6-vinylpurines and 6-ethynylpurines

    Czech Academy of Sciences Publication Activity Database

    Kuchař, Martin; Pohl, Radek; Votruba, Ivan; Hocek, Michal

    -, č. 22 (2006), s. 5083 -5098 ISSN 1434-193X R&D Projects: GA MŠk(CZ) 1M0508; GA AV ČR(CZ) 1QS400550501 Institutional research plan: CEZ:AV0Z40550506 Keywords : purines * Michael addition * conjugate additions * cross-coupling Subject RIV: CC - Organic Chemistry Impact factor: 2.769, year: 2006

  7. Michael Jackson, Bin Laden and I: functions of positive and negative, public and private flashbulb memories.

    Science.gov (United States)

    Demiray, Burcu; Freund, Alexandra M

    2015-01-01

    This study examined the perceived psychosocial functions of flashbulb memories: It compared positive and negative public flashbulb memories (positive: Bin Laden's death, negative: Michael Jackson's death) with private ones (positive: pregnancy, negative: death of a loved one). A sample of n = 389 young and n = 176 middle-aged adults answered canonical category questions used to identify flashbulb memories and rated the personal significance, the psychological temporal distance, and the functions of each memory (i.e., self-continuity, social-boding, directive functions). Hierarchical regressions showed that, in general, private memories were rated more functional than public memories. Positive and negative private memories were comparable in self-continuity and directionality, but the positive private memory more strongly served social functions. In line with the positivity bias in autobiographical memory, positive flashbulb memories felt psychologically closer than negative ones. Finally, middle-aged adults rated their memories as less functional regarding self-continuity and social-bonding than young adults. Results are discussed regarding the tripartite model of autobiographical memory functions.

  8. Nacionalismos e internacionalismo: um debate entre Michael Löwy e Michel Cahen

    Directory of Open Access Journals (Sweden)

    Ângela Lazagna

    2008-11-01

    Full Text Available Este artigo consiste em um debate realizado entre Michel Löwy e Michael Cahen em meados dos anos 1990 e revisto para esta publicação. Mesmo que a discussão refira-se a acontecimentos que até certo ponto podem ser considerados datados, a preocupação de fundo que é comum a esses artigos concede-lhes atualidade: a necessidade do aprofundamento de uma reflexão, a partir da teoria marxista, sobre o problema dos nacionalismos e do internacionalismo em tempos de mundialização. Esse aprofundamento, segundo os autores, faz-se necessário sobretudo por meio de uma reflexão que rompa criticamente com uma visão eurocêntrica dos diferentes nacionalismos e que supere a atitude de muitos marxistas de desprezarem tudo aquilo que não seja diretamente relevante à "consciência de classe".

  9. A man and his island: The island mirror in Michael Crummey’s Sweetland

    Directory of Open Access Journals (Sweden)

    Laurie Brinklow

    2016-05-01

    Full Text Available Between 1946 and 1975, dozens of islands and outports in the Canadian province of Newfoundland and Labrador were abandoned as part of a government resettlement policy. Families and communities were torn apart, and a culture and way of life that revolved around the fishery changed irrevocably. The practice, which continues to this day, has been well documented, particularly by artists and writers. Michael Crummey’s 2014 novel Sweetland is a recent iteration. The relationship between humans and place is complex: on an island, with compressed space and a very real boundary that is the ocean, emotional attachments to one’s place are often heightened and distilled. What happens when a person is displaced from his or her island; when bonds of attachment are severed and one’s mirrored double is destroyed? Sweetland offers a fictional lens through which we see an example of a mirrored relationship between an island protagonist and his island setting. Exploring themes of attachment to place, and what Barry Lopez calls a “storied” or “reciprocal” relationship with the land, this paper examines what happens to a man when confronted with leaving an island he knows as deeply as his own body and soul; and how the island reacts.

  10. Selective bird predation on the peppered moth: the last experiment of Michael Majerus.

    Science.gov (United States)

    Cook, L M; Grant, B S; Saccheri, I J; Mallet, J

    2012-08-23

    Colour variation in the peppered moth Biston betularia was long accepted to be under strong natural selection. Melanics were believed to be fitter than pale morphs because of lower predation at daytime resting sites on dark, sooty bark. Melanics became common during the industrial revolution, but since 1970 there has been a rapid reversal, assumed to have been caused by predators selecting against melanics resting on today's less sooty bark. Recently, these classical explanations of melanism were attacked, and there has been general scepticism about birds as selective agents. Experiments and observations were accordingly carried out by Michael Majerus to address perceived weaknesses of earlier work. Unfortunately, he did not live to publish the results, which are analysed and presented here by the authors. Majerus released 4864 moths in his six-year experiment, the largest ever attempted for any similar study. There was strong differential bird predation against melanic peppered moths. Daily selection against melanics (s ≈ 0.1) was sufficient in magnitude and direction to explain the recent rapid decline of melanism in post-industrial Britain. These data provide the most direct evidence yet to implicate camouflage and bird predation as the overriding explanation for the rise and fall of melanism in moths.

  11. Creative Industries, Value Theory and Michael Heinrich’s New Reading of Marx

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    Frederick H. Pitts

    2015-06-01

    Full Text Available This article utilises the new reading of Marx found in the work of Michael Heinrich to analyse the creative industries. It considers the role played in the production of value by the labour that takes place in the sphere of circulation. The specific focus is on creative industries such as graphic design, advertising and branding. It applies Heinrich's conceptualisation of 'social validation' to these sectors. This suggests that valorisation depends upon goods and services attaining commodity status by selling for money. Value is subject to this validation. The capitalist use of advertising, graphic design and branding guarantees the possibility of this validation. Using Heinrich, it reevaluates claims made about the creative industries and cognate fields in three main respects. First, it exposes as inadequate certain Marxist understandings of productive and unproductive labour and the place of circulation activities within this distinction. Second, it refutes autonomist Marxist claims as to the immeasurability of immaterial labour and the redundancy of the law of value. Third, it suggests that creative industries possess a significant role in a capitalist economy blighted by a necessity towards the overproduction of commodities.

  12. Diffusible gradients are out - an interview with Lewis Wolpert. Interviewed by Richardson, Michael K.

    Science.gov (United States)

    Wolpert, Lewis

    2009-01-01

    In 1969, Lewis Wolpert published a paper outlining his new concepts of "pattern formation" and "positional information". He had already published research on the mechanics of cell membranes in amoebae, and a series of classic studies of sea urchin gastrulation with Trygve Gustavson. Wolpert had presented his 1969 paper a year earlier at a Woods Hole conference, where it received a very hostile reception: "I wasnt asked back to America for many years!". But with Francis Crick lining up in support of diffusible morphogen gradients, positional information eventually became established as a guiding principle for research into biological pattern formation. It is now clear that pattern formation is much more complex than could possibly have been imagined in 1969. But Wolpert still believes in positional information, and regards intercalation during regeneration as its best supporting evidence. However, he and others doubt that diffusible morphogen gradients are a plausible mechanism: "Diffusible gradients are too messy", he says. Since his retirement, Lewis Wolpert has remained active as a theoretical biologist and continues to publish in leading journals. He has also campaigned for a greater public understanding of the stigma of depression. He was interviewed at home in London on July 26th, 2007 by Michael Richardson.

  13. Regression and new beginnings: Michael, Alice and Enid Balint and the circulation of ideas.

    Science.gov (United States)

    Sklar, Jonathan

    2012-08-01

    This article offers a new evaluation of Michael Balint's history. It starts with his growing up in Hungary and examines the central concepts of his writing: the analytic pair, regression and the basic fault and creativity, up to and including his renowned work on the eponymous Balint groups (which forged a unique link between psychoanalysis and medicine). While his name is, of course, well known, this article aims to bring his ideas to the attention of a modern analytic audience. Having trained in the 1920s with Ferenczi, Balint brought Ferenczi's literary inheritance to England where he lived until his death in 1970. His connections to Klein, Winnicott and Lacan, all of whom respected his analytic stance, are also examined. Furthermore, this article argues that his ideas were filtered through the theoretical lens of his first wife Alice Balint and later through Enid Balint, both of whom played a key - and rarely recognised - role in the development of his thought. It ends with a brief discussion of his ideas on analytic training and his quest, successful only after his death, to publish the complete Freud-Ferenczi correspondence, together with Ferenczi's diary. Copyright © 2012 Institute of Psychoanalysis.

  14. Losing Touch: A Theology of Death for Michael Haneke’s Amour

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    Taylor Worley

    2016-11-01

    Full Text Available This proposed theology of death for Michael Haneke’s Amour, a fraught but poignant piece of cinema, will employ Martin Heidegger’s existentialism to reframe the ethical structure of the film and apply a “lived theology” rejoinder to its perceived hopelessness. The proposal will address the question of ethics in relation to Haneke’s cinema, in particular his seemingly nihilistic perspective and confrontational style. To do so, it will revisit the film itself and examine the ways that Georges and Anne’s love is tested. Principally, we examine the film’s great question, which—in the filmmaker’s own words—is: “How do I cope with the suffering of a loved one?” With aid from the theologian Dietrich Bonhoeffer, this ‘lived theology’ proposal will attempt to give an account of love’s irrepressible strength in the midst of even astounding suffering. While Heidegger’s ethic of resoluteness calls for interiority and solitude, Bonhoeffer’s account of death more satisfactorily invokes a transcendent summons contained within our own pledges to loved ones. Such a theological reading of Haneke’s Amour will draw two distinct conclusions: first, the film exposes the superficiality of any hoped-for solitude or escape from a loved one’s death, and secondly, it demonstrates that the mutuality of authentic love entails impossible sacrifices.

  15. La figura del libro in Die unendliche Geschichte di Michael Ende: da finestra a varco

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    Elena Di Cesare

    2015-01-01

    Full Text Available The book is an object which can be considered as a window in the novel Die unendliche Geschichte (1979 written by Michael Ende. It allows Bastian to look at the world of Phantasien and to communicate indirectly with the Childlike Empress. Furthermore, this object will show its function as an symbol of evolution, which will enable the passage of the protagonist into the world of Phantasien: first the book appears as a window, then it becomes a two-way-mirror that allows Bastian and Atreju to look at each other, and finally it turns into a gate which enables them to live many adventures together. Die unendliche Geschichte can be considered as a modern Bildungsroman in which the young protagonist gradually reaches his maturation. This progress must be seen in a psychological perspective: it is the growth of a child-mind through literature which makes reference to the German novel tradition but also (as children’s literature to the world of unconsciousness.

  16. “This fabulous flotsam”: Michael Moorcock’s Urban Anthropology in “London under London”

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    Houswitschka Christoph

    2015-07-01

    Full Text Available Michael Moorcock is often described as “one of the most prolific and varied writers working in Britain” (Malcolm 146. His success as a writer and editor of science fiction and fantasy literature is well established, but he is also the author of two novels about London, Mother London (1988 and King of the City (2000. Hardly known, Mother London by Michael Moorcock, offers itself to a variety of approaches that have been widely discussed in the context of studies on English literature during the Thatcher years, post-modernism, and psycho-geography. The novel resonates with the author’s own childhood in war-time London without being autobiographical. It tells the story of three Londoners who were traumatised during the Blitz. The following article focuses on the mysteries of subterranean London that represents the hidden and unconscious identities of its inhabitants in the post-war period.

  17. O que é a Multidão? Questões para Michael Hardt e Antonio Negri

    Directory of Open Access Journals (Sweden)

    Nicholas Brown

    2006-07-01

    Full Text Available Multidão, livro mais recente de Michael Hardt e Antonio Negri, é uma tentativa de nomear e compreender as condições que envolvem a dinâmica social do século xxi. Na entrevista a seguir, Hardt e Negri discorrem sobre as possibilidades de constituição da multidão como agente político, discutem os fundamentos do livro e defendem conceitos que consideram determinantes para a compreensão dos novos tempos, tais como biopolítica e biopoder.Multitude, Michael Hardt and Antonio Negri’s latest book, is an attempt at understanding conditions involving social dynamics in the xxi century. In the interview below, Hardt and Negri consider the constitution of the multitude as a political agent, discuss the structure of their book and support concepts seen as crucial for the comprehension of our time, such as biopolitics and biopower.

  18. Cardiac autonomic dysfunction is associated with high-risk albumin-to-creatinine ratio in young adolescents with type 1 diabetes in AdDIT (adolescent type 1 diabetes cardio-renal interventional trial).

    Science.gov (United States)

    Cho, Yoon Hi; Craig, Maria E; Davis, Elizabeth A; Cotterill, Andrew M; Couper, Jennifer J; Cameron, Fergus J; Benitez-Aguirre, Paul Z; Dalton, R Neil; Dunger, David B; Jones, Timothy W; Donaghue, Kim C

    2015-04-01

    This study examined the association between cardiac autonomic dysfunction and high albumin-to-creatinine ratio (ACR) in adolescents with type 1 diabetes. Adolescents recruited as part of a multicenter screening study (n = 445, 49% female, aged 10-17 years, mean duration 6.9 years; mean HbA1c 8.4%, 68 mmol/mol) underwent a 10-min continuous electrocardiogram recording for heart rate variability analysis. Time-domain heart rate variability measures included baseline heart rate, SD of the R-R interval (SDNN), and root mean squared difference of successive R-R intervals (RMSSD). Spectral analysis included sympathetic (low-frequency) and parasympathetic (high-frequency) components. Standardized ACR were calculated from six early morning urine collections using an established algorithm, reflecting age, sex, and duration, and stratified into ACR tertiles, where the upper tertile reflects higher nephropathy risk. The upper-tertile ACR group had a faster heart rate (76 vs. 73 bpm; P < 0.01) and less heart rate variability (SDNN 68 vs. 76 ms, P = 0.02; RMSSD 63 vs. 71 ms, P = 0.04). HbA1c was 8.5% (69 mmol/mmol) in the upper tertile vs. 8.3% (67 mmol/mol) in the lower tertiles (P = 0.07). In multivariable analysis, upper-tertile ACR was associated with faster heart rate (β = 2.5, 95% CI 0.2-4.8, P = 0.03) and lower RMSSD (β = -9.5, 95% CI -18.2 to -0.8, P = 0.03), independent of age and HbA1c. Adolescents at potentially higher risk for nephropathy show an adverse cardiac autonomic profile, indicating sympathetic overdrive, compared with the lower-risk group. Longitudinal follow-up of this cohort will further characterize the relationship between autonomic and renal dysfunction and the effect of interventions in this population. © 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

  19. The works of Joseph and Michael Haydn in Ondřej Horník's collection

    Czech Academy of Sciences Publication Activity Database

    Freemanová, Michaela

    2017-01-01

    Roč. 9, 1-2 (2017), s. 14-23 ISSN 1803-7828 Institutional support: RVO:68378076 Keywords : music manuscripts * Joseph Haydn * Michael Haydn * Ondřej Horník's collection * church music Subject RIV: AL - Art, Architecture, Cultural Heritage OBOR OECD: Performing arts studies ( Music ology, Theater science, Dramaturgy) http://www.nm.cz/publikace/archiv.php?id=16

  20. Leadership and creativity in public services: An interview with Lord Michael Bichard, Chair of the National Audit Office

    OpenAIRE

    Bolden, R.; O'Regan, N.

    2018-01-01

    This interview with Lord Michael Bichard, one of the most distinguished public sector leaders in the UK, explores his ideas around the relationship between leadership, creativity and innovation. A champion of place-based approaches to public services, where citizens are actively involved in service design, delivery and appraisal, Bichard advocates the need for inclusive and supportive leadership that enables the emergence of the kinds of creativity required to respond to the financial challen...

  1. Catalytic Enantioselective Synthesis of 3,4-Unsubstituted Thiochromenes through Sulfa-Michael/Julia-Kocienski Olefination Cascade Reaction.

    Science.gov (United States)

    Simlandy, Amit Kumar; Mukherjee, Santanu

    2017-05-05

    A highly enantioselective cascade sulfa-Michael/Julia-Kocienski olefination reaction between 2-mercaptobenzaldehydes and β-substituted vinyl PT-sulfones has been realized for the synthesis of 3,4-unsubstituted 2H-thiochromenes. This reaction, catalyzed by diphenylprolinol TMS ether, proceeds through an aromatic iminium intermediate and furnishes a wide range of 2-substiuted 2H-thiochromenes with excellent enantioselectivities (up to 99:1 er).

  2. Corrupting Capitalism: Michael Ende’s Momo and “Cathedral Station”

    Directory of Open Access Journals (Sweden)

    Heike Polster

    2016-01-01

    Full Text Available Michael Ende, the well-known author of The Neverending Story , foresaw dramatic changes in the fabric of society resulting from a turn toward neoliberal policies. One such far-reaching and dangerous change has to do with a diminishing of temporal autonomy, the ability to freely determine the use and meaning of our time. This article explores how neoliberalism is shaping our concept of time and our experience of it. In an effort to demonstrate the process and the line of reasoning behind the monetization of time, and to connect time to more qualitative considerations of the human condition, I shall demonstrate how Ende conceptualizes time as an integral part of the accumulation process of capitalism. I also discuss a fairly cryptic short story, “Cathedral Station,” that envisions “the mystery of money.” Utilizing Walter Benjamin’s critique issued in his 1921 fragment “Capitalism as Religion,” I outline Ende’s dystopian vision of the uncontested, unquestioned reign of capitalism as a religious cult. Read together, the novel and the short story offer a way of contrasting two extreme byproducts of capitalism’s colonization of time, namely what I would call an “ideology of work” and an “ideology of growth.” The first of these is a result of capitalism’s commodification of time according to liberal ideals such as choice, freedom, and self-interest. The second is a decidedly neoliberal phenomenon in that the “financialization of everything,” to use David Harvey’s phrase, results in the ever-present expectation of unlimited, exponential growth. By drawing out these two interconnected ideologies through close readings, the subtle processes of capitalism’s colonization of time are revealed.

  3. Suspense, culpa y cintas de vídeo. Caché/Escondido de Michael Haneke

    Directory of Open Access Journals (Sweden)

    Miguel Martínez-Cabeza

    2011-12-01

    Full Text Available Caché/Escondido (2005 representa dentro de la filmografía de Michael Haneke el ejemplo más destacado de síntesis de los planteamientos formales e ideológicos del cineasta austriaco. Este artículo analiza el filme como manifiesto cinematográfico y como explotación de las convenciones genéricas para construir un modelo de espectador reflexivo. La investigación del modo en que el director plantea y abandona las técnicas del suspense aporta claves para explicar el éxito casi unánime de crítica y la respuesta mucho menos homogénea de las audiencias. El desencadenante de la trama, unas cintas de vídeo que reciben los Laurent, es alusión directa a Carretera Perdida (1997 de David Lynch; no obstante, el misterio acerca del autor de la videovigilancia pierde interés en relación al sentimiento de culpa que desencadena en el protagonista. El episodio infantil de celos y venganza hacia un niño argelino y la actitud del Georges adulto representan una alegoría de la relación de Francia con su pasado colonial que tampoco cierra la narración de Haneke. Es precisamente la apertura formal con que el filme (desestructura cuestiones actuales como el límite entre la responsabilidad individual y colectiva lo que conforma un espectador tan distanciado de la diégesis como consciente de su propio papel de observador.

  4. An additional bolus of rapid-acting insulin to normalise postprandial cardiovascular risk factors following a high-carbohydrate high-fat meal in patients with type 1 diabetes: A randomised controlled trial.

    Science.gov (United States)

    Campbell, Matthew D; Walker, Mark; Ajjan, Ramzi A; Birch, Karen M; Gonzalez, Javier T; West, Daniel J

    2017-07-01

    To evaluate an additional rapid-acting insulin bolus on postprandial lipaemia, inflammation and pro-coagulation following high-carbohydrate high-fat feeding in people with type 1 diabetes. A total of 10 males with type 1 diabetes [HbA 1c 52.5 ± 5.9 mmol/mol (7.0% ± 0.5%)] underwent three conditions: (1) a low-fat (LF) meal with normal bolus insulin, (2), a high-fat (HF) meal with normal bolus insulin and (3) a high-fat meal with normal bolus insulin with an additional 30% insulin bolus administered 3-h post-meal (HFA). Meals had identical carbohydrate and protein content and bolus insulin dose determined by carbohydrate-counting. Blood was sampled periodically for 6-h post-meal and analysed for triglyceride, non-esterified-fatty acids, apolipoprotein B48, glucagon, tumour necrosis factor alpha, fibrinogen, human tissue factor activity and plasminogen activator inhibitor-1. Continuous glucose monitoring captured interstitial glucose responses. Triglyceride concentrations following LF remained similar to baseline, whereas triglyceride levels following HF were significantly greater throughout the 6-h observation period. The additional insulin bolus (HFA) normalised triglyceride similarly to low fat 3-6 h following the meal. HF was associated with late postprandial elevations in tumour necrosis factor alpha, whereas LF and HFA was not. Fibrinogen, plasminogen activator inhibitor-1 and tissue factor pathway levels were similar between conditions. Additional bolus insulin 3 h following a high-carbohydrate high-fat meal prevents late rises in postprandial triglycerides and tumour necrosis factor alpha, thus improving cardiovascular risk profile.

  5. Enantioselective organocatalyzed Oxa-Michael-Aldol cascade reactions: Construction of chiral 4H-chromenes with a trifluoromethylated tetrasubstituted carbon stereocenter

    KAUST Repository

    Zhang, Jing; Ajitha, Manjaly John; He, Lin; Liu, Kai; Dai, Bin; Huang, Kuo-Wei

    2015-01-01

    The first organocatalytic asymmetric synthesis of 4H-chromenes bearing a trifluoromethylated tetrasubstituted carbon center is presented. Chiral secondary amines promote the oxa-Michael-aldol cascade reaction between alkynals and 2

  6. Why There Are Certain Parallels Between Joachim C. Fest’s Hitler-Biography and Michael Wolff’s Trump-Book

    Directory of Open Access Journals (Sweden)

    Christian Fuchs

    2018-02-01

    Full Text Available Joachim C. Fest published one of the most widely read Hitler biographies in 1973. Are there parallels of its analytical approach to Michael Wolff’s “Fire and Fury: Inside the Trump White House”?

  7. Object-Oriented Type Systems

    DEFF Research Database (Denmark)

    Schwartzbach, Michael Ignatieff; Palsberg, Jens

    binding. Existing languages employ different type systems, and it can be difficult to compare, evaluate and improve them, since there is currently no uniform theory for such languages. This book provides such a theory. The authors review the type systems of Simula, Smalltalk, C++ and Eiffel and present......Object-Oriented Type Systems Jens Palsberg and Michael I. Schwartzbach Aarhus University, Denmark Type systems are required to ensure reliability and efficiency of software. For object-oriented languages, typing is an especially challenging problem because of inheritance, assignment, and late...... a type system that generalizes and explains them. The theory is based on an idealized object-oriented language called BOPL (Basic Object Programming Language), containing common features of the above languages. A type system, type inference algorithm, and typings of inheritance and genericity...

  8. Protocol for the ADDITION-Plus study: a randomised controlled trial of an individually-tailored behaviour change intervention among people with recently diagnosed type 2 diabetes under intensive UK general practice care

    Directory of Open Access Journals (Sweden)

    Fanshawe Tom

    2011-04-01

    Full Text Available Abstract Background The increasing prevalence of type 2 diabetes poses both clinical and public health challenges. Cost-effective approaches to prevent progression of the disease in primary care are needed. Evidence suggests that intensive multifactorial interventions including medication and behaviour change can significantly reduce cardiovascular morbidity and mortality among patients with established type 2 diabetes, and that patient education in self-management can improve short-term outcomes. However, existing studies cannot isolate the effects of behavioural interventions promoting self-care from other aspects of intensive primary care management. The ADDITION-Plus trial was designed to address these issues among recently diagnosed patients in primary care over one year. Methods/Design ADDITION-Plus is an explanatory randomised controlled trial of a facilitator-led, theory-based behaviour change intervention tailored to individuals with recently diagnosed type 2 diabetes. 34 practices in the East Anglia region participated. 478 patients with diabetes were individually randomised to receive (i intensive treatment alone (n = 239, or (ii intensive treatment plus the facilitator-led individual behaviour change intervention (n = 239. Facilitators taught patients key skills to facilitate change and maintenance of key behaviours (physical activity, dietary change, medication adherence and smoking, including goal setting, action planning, self-monitoring and building habits. The intervention was delivered over one year at the participant's surgery and included a one-hour introductory meeting followed by six 30-minute meetings and four brief telephone calls. Primary endpoints are physical activity energy expenditure (assessed by individually calibrated heart rate monitoring and movement sensing, change in objectively measured dietary intake (plasma vitamin C, medication adherence (plasma drug levels, and smoking status (plasma cotinine levels at

  9. Protocol for the ADDITION-Plus study: a randomised controlled trial of an individually-tailored behaviour change intervention among people with recently diagnosed type 2 diabetes under intensive UK general practice care.

    Science.gov (United States)

    Griffin, Simon J; Simmons, Rebecca K; Williams, Kate M; Prevost, A Toby; Hardeman, Wendy; Grant, Julie; Whittle, Fiona; Boase, Sue; Hobbis, Imogen; Brage, Soren; Westgate, Kate; Fanshawe, Tom; Sutton, Stephen; Wareham, Nicholas J; Kinmonth, Ann Louise

    2011-04-04

    The increasing prevalence of type 2 diabetes poses both clinical and public health challenges. Cost-effective approaches to prevent progression of the disease in primary care are needed. Evidence suggests that intensive multifactorial interventions including medication and behaviour change can significantly reduce cardiovascular morbidity and mortality among patients with established type 2 diabetes, and that patient education in self-management can improve short-term outcomes. However, existing studies cannot isolate the effects of behavioural interventions promoting self-care from other aspects of intensive primary care management. The ADDITION-Plus trial was designed to address these issues among recently diagnosed patients in primary care over one year. ADDITION-Plus is an explanatory randomised controlled trial of a facilitator-led, theory-based behaviour change intervention tailored to individuals with recently diagnosed type 2 diabetes. 34 practices in the East Anglia region participated. 478 patients with diabetes were individually randomised to receive (i) intensive treatment alone (n = 239), or (ii) intensive treatment plus the facilitator-led individual behaviour change intervention (n = 239). Facilitators taught patients key skills to facilitate change and maintenance of key behaviours (physical activity, dietary change, medication adherence and smoking), including goal setting, action planning, self-monitoring and building habits. The intervention was delivered over one year at the participant's surgery and included a one-hour introductory meeting followed by six 30-minute meetings and four brief telephone calls. Primary endpoints are physical activity energy expenditure (assessed by individually calibrated heart rate monitoring and movement sensing), change in objectively measured dietary intake (plasma vitamin C), medication adherence (plasma drug levels), and smoking status (plasma cotinine levels) at one year. We will undertake an intention

  10. N,2,3,4-Tetrasubstituted Pyrrolidines through Tandem Lithium Amide Conjugate Addition/Radical Cyclization/Oxygenation Reactions

    Czech Academy of Sciences Publication Activity Database

    Kafka, František; Pohl, Radek; Císařová, I.; Mackman, R.; Bahador, G.; Jahn, Ullrich

    2016-01-01

    Roč. 2016, č. 22 (2016), s. 3862-3871 ISSN 1434-193X R&D Projects: GA ČR GA13-40188S Grant - others:COST(XE) CM1201 Institutional support: RVO:61388963 Keywords : tandem reactions * nitrogen heterocycles * Michael addition * radical reactions * cyclization * enolates Subject RIV: CC - Organic Chemistry Impact factor: 2.834, year: 2016

  11. Incremental Costs and Cost Effectiveness of Intensive Treatment in Individuals with Type 2 Diabetes Detected by Screening in the ADDITION-UK Trial: An Update with Empirical Trial-Based Cost Data.

    Science.gov (United States)

    Laxy, Michael; Wilson, Edward C F; Boothby, Clare E; Griffin, Simon J

    2017-12-01

    There is uncertainty about the cost effectiveness of early intensive treatment versus routine care in individuals with type 2 diabetes detected by screening. To derive a trial-informed estimate of the incremental costs of intensive treatment as delivered in the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care-Europe (ADDITION) trial and to revisit the long-term cost-effectiveness analysis from the perspective of the UK National Health Service. We analyzed the electronic primary care records of a subsample of the ADDITION-Cambridge trial cohort (n = 173). Unit costs of used primary care services were taken from the published literature. Incremental annual costs of intensive treatment versus routine care in years 1 to 5 after diagnosis were calculated using multilevel generalized linear models. We revisited the long-term cost-utility analyses for the ADDITION-UK trial cohort and reported results for ADDITION-Cambridge using the UK Prospective Diabetes Study Outcomes Model and the trial-informed cost estimates according to a previously developed evaluation framework. Incremental annual costs of intensive treatment over years 1 to 5 averaged £29.10 (standard error = £33.00) for consultations with general practitioners and nurses and £54.60 (standard error = £28.50) for metabolic and cardioprotective medication. For ADDITION-UK, over the 10-, 20-, and 30-year time horizon, adjusted incremental quality-adjusted life-years (QALYs) were 0.014, 0.043, and 0.048, and adjusted incremental costs were £1,021, £1,217, and £1,311, resulting in incremental cost-effectiveness ratios of £71,232/QALY, £28,444/QALY, and £27,549/QALY, respectively. Respective incremental cost-effectiveness ratios for ADDITION-Cambridge were slightly higher. The incremental costs of intensive treatment as delivered in the ADDITION-Cambridge trial were lower than expected. Given UK willingness-to-pay thresholds in patients with screen

  12. Object-Oriented Type Systems

    DEFF Research Database (Denmark)

    Schwartzbach, Michael Ignatieff; Palsberg, Jens

    a type system that generalizes and explains them. The theory is based on an idealized object-oriented language called BOPL (Basic Object Programming Language), containing common features of the above languages. A type system, type inference algorithm, and typings of inheritance and genericity......Object-Oriented Type Systems Jens Palsberg and Michael I. Schwartzbach Aarhus University, Denmark Type systems are required to ensure reliability and efficiency of software. For object-oriented languages, typing is an especially challenging problem because of inheritance, assignment, and late...... are provided for BOPL. Throughout, the results are related to the languages on which BOPL is based. This text offers advanced undergraduates and professional software developers a sound understanding of the key aspects of object-oriented type systems. All algorithms are implemented in a freely available...

  13. In situ forming poly(ethylene glycol)- Poly(L -lactide) hydrogels via michael addition: Mechanical properties, degradation, and protein release

    NARCIS (Netherlands)

    Buwalda, S.J.; Dijkstra, Pieter J.; Feijen, Jan

    2012-01-01

    Chemically crosslinked hydrogels are prepared at remarkably low macromonomer concentrations from 8-arm poly(ethylene glycol)-poly(L-lactide) star block copolymers bearing acrylate end groups (PEG-(PLLAn)8-AC, n = 4 or 12) and multifunctional PEG thiols (PEG-(SH)n, n = 2, 4, or 8) through a

  14. Tandem Aldol-Michael Reactions in Aqueous Diethylamine Medium: A Greener and Efficient Approach to Bis-Pyrimidine Derivatives

    Directory of Open Access Journals (Sweden)

    Abdullah M. Al-Majid

    2013-12-01

    Full Text Available A simple protocol, involving the green synthesis for the construction of novel bis-pyrimidine derivatives, 3a–i and 4a–e are accomplished by the aqueous diethylamine media promoted tandem Aldol-Michael reaction between two molecules of barbituric acid derivatives 1a,b with various aldehydes. This efficient synthetic protocol using an economic and environmentally friendly reaction media with versatility and shorter reaction time provides bis-pyrimidine derivatives with high yields (88%–99%.

  15. Kochin, Michael S. 2009. Five Chapters on Rhetoric: Character, Action, Things, Nothing and Art (University Park: Pennsylvania State University Press

    Directory of Open Access Journals (Sweden)

    Eithan Orkibi

    2010-04-01

    Full Text Available Deux constatations traversent le nouvel ouvrage de Michael Kochin, et nous invitent à reconsidérer la rhétorique dans la communication persuasive. D’abord, que ce sont les événements concrets et les faits mis à l’épreuve qui ont la plus grande force de conviction ; et ensuite, que le discours a souvent une fonction autre que la persuasion : celle de maintenir les canaux de communication pour sauvegarder les relations et les institutions humaines. Pour l’auteur de cet ouvrage qui porte sur les...

  16. A propósito del libro "Accounting theory: research, regulation and accounting practice" de Michael Gaffikin

    Directory of Open Access Journals (Sweden)

    Garcia Nohora

    2012-09-01

    Full Text Available En el libro “Accounting theory: research, regulation and accounting practice”, el profesor australiano Michael Gaffikin ofrece al lector una idea del origen y amplio desenvolvimiento de la teoría contable durante el siglo XX “cuyo desarrollo ha sido dominado por Estados Unidos” (Gaffikin, 2008, p. 32. Plantea, igualmente, los desafíos y problemas actuales de la regulación y la profesión contable. Por ejemplo, el autor precisa que ante la incapacidad de lograr un acuerdo sobre las mediciones apropiadas, la tendencia mundial es a instaurar medidas determinadas arbitrariamente (Gaffikin, 2008, p. 154.

  17. New 'Master of Science in Nuclear Engineering' study course launched. Interview with Professor Horst-Michael Prasser

    International Nuclear Information System (INIS)

    Anon.

    2008-01-01

    In the fall of 2008, the Zurich Technical University (ETH) and the Lausanne EPF will launch their joint master course of studies in Nuclear Engineering. Horst-Michael Prasser, Professor for Nuclear Energy Systems at Zurich ETH, is responsible for designing the course. In this interview he comments, among other things, on fundamental questions which may determine a future student's choice of a course of studies, and on the special opportunities offered by the new Nuclear Engineering course. Other subjects addressed include the renaissance of nuclear power and the future prospects of safety research and new reactor developments. (orig.)

  18. ‘Doxographical or Philosophical History of Philosophy: On Michael Frede’s Precepts for Writing the History of Philosophy’

    DEFF Research Database (Denmark)

    Catana, Leo

    2016-01-01

    In a series of articles from the 1980s and 1990s, Michael Frede analysed the history of histories of philosophy written over the last three hundred years. According to Frede, modern scholars have degenerated into what he calls a “doxographical” mode of writing the history of philosophy. Instead, he...... argued, these scholars should write what he called “philosophical” history of philosophy, first established in the last decades of the seventeenth century but since abandoned. In the present article it is argued that Frede’s reconstruction of the history of histories of philosophy is historically...

  19. Constructing Singapore : Elitism, Ethnicity and the Nation-Building Project, Michael D. Barr & Zlatko Skrbis

    Directory of Open Access Journals (Sweden)

    Jean-Louis Margolin

    2010-12-01

    Full Text Available Michael Barr, seul ou en collaboration, est depuis une décennie l’un des auteurs les plus prolifiques et les plus reconnus sur la structuration politique et sociologique du Singapour contemporain. Longtemps attaché à l’université du Queensland (Brisbane, aujourd’hui à Flinders (Adelaide, il est assez représentatif de la nouvelle génération (singapourienne aussi bien qu’étrangère des spécialistes de la cité-état : fermement critique, et parfois même hyper-critique, elle n’en reconnaît pas m...

  20. Advances in Statistical Control, Algebraic Systems Theory, and Dynamic Systems Characteristics A Tribute to Michael K Sain

    CERN Document Server

    Won, Chang-Hee; Michel, Anthony N

    2008-01-01

    This volume - dedicated to Michael K. Sain on the occasion of his seventieth birthday - is a collection of chapters covering recent advances in stochastic optimal control theory and algebraic systems theory. Written by experts in their respective fields, the chapters are thematically organized into four parts: Part I focuses on statistical control theory, where the cost function is viewed as a random variable and performance is shaped through cost cumulants. In this respect, statistical control generalizes linear-quadratic-Gaussian and H-infinity control. Part II addresses algebraic systems th

  1. Cost-effectiveness of intensive multifactorial treatment compared with routine care for individuals with screen-detected Type 2 diabetes: analysis of the ADDITION-UK cluster-randomized controlled trial

    Science.gov (United States)

    Tao, L; Wilson, E C F; Wareham, N J; Sandbæk, A; Rutten, G E H M; Lauritzen, T; Khunti, K; Davies, M J; Borch-Johnsen, K; Griffin, S J; Simmons, R K

    2015-01-01

    Aims To examine the short- and long-term cost-effectiveness of intensive multifactorial treatment compared with routine care among people with screen-detected Type 2 diabetes. Methods Cost–utility analysis in ADDITION-UK, a cluster-randomized controlled trial of early intensive treatment in people with screen-detected diabetes in 69 UK general practices. Unit treatment costs and utility decrement data were taken from published literature. Accumulated costs and quality-adjusted life years (QALYs) were calculated using ADDITION-UK data from 1 to 5 years (short-term analysis, n = 1024); trial data were extrapolated to 30 years using the UKPDS outcomes model (version 1.3) (long-term analysis; n = 999). All costs were transformed to the UK 2009/10 price level. Results Adjusted incremental costs to the NHS were £285, £935, £1190 and £1745 over a 1-, 5-, 10- and 30-year time horizon, respectively (discounted at 3.5%). Adjusted incremental QALYs were 0.0000, – 0.0040, 0.0140 and 0.0465 over the same time horizons. Point estimate incremental cost-effectiveness ratios (ICERs) suggested that the intervention was not cost-effective although the ratio improved over time: the ICER over 10 years was £82 250, falling to £37 500 over 30 years. The ICER fell below £30 000 only when the intervention cost was below £631 per patient: we estimated the cost at £981. Conclusion Given conventional thresholds of cost-effectiveness, the intensive treatment delivered in ADDITION was not cost-effective compared with routine care for individuals with screen-detected diabetes in the UK. The intervention may be cost-effective if it can be delivered at reduced cost. PMID:25661661

  2. The chemical foundations of nitroalkene fatty acid signaling through addition reactions with thiols.

    Science.gov (United States)

    Turell, Lucía; Steglich, Martina; Alvarez, Beatriz

    2018-03-22

    Nitroalkene fatty acids can be formed in vivo and administered exogenously. They exert pleiotropic signaling actions with cytoprotective and antiinflammatory effects. The presence of the potent electron withdrawing nitro group confers electrophilicity to the adjacent β-carbon. Thiols (precisely, thiolates) are strong nucleophiles and can react with nitroalkene fatty acids through reversible Michael addition reactions. In addition, nitroalkene fatty acids can undergo several other processes including metabolic oxidation, reduction, esterification, nitric oxide release and partition into hydrophobic compartments. The signaling actions of nitroalkenes are mainly mediated by reactions with critical thiols in regulatory proteins. Thus, the thio-Michael addition reaction provides a framework for understanding the molecular basis of the biological effects of nitroalkene fatty acids at the crossroads of thiol signaling and electrophilic lipid signaling. In this review, we describe the reactions of nitroalkene fatty acids in biological contexts. We focus on the Michael addition-elimination reaction with thiols and its mechanism, and extrapolate kinetic and thermodynamic considerations to in vivo settings. Copyright © 2018 Elsevier Inc. All rights reserved.

  3. Trajetória acadêmica e perspectivas acerca do turismo sob o olhar de Colin Michael Hall

    Directory of Open Access Journals (Sweden)

    Elayne Gouveia da Silva

    2016-04-01

    Full Text Available Este trabalho versa sobre a visão do Colin Michael Hall na temática do turismo. Para analisar essa temática imbricou-se em duas leituras principais como parâmetro para a discussão. A primeira é a obra “Planejamento turístico: política, processo e planejamento” e, a segunda, “Turismo como El Ciencia Social de La Movilidade”. Estas obras marcam a mudança de visão do autor, onde o mesmo se dedica a fomentar um novo olhar sobre o turismo suscitando sete aspectos para se pensar no turismo. O objetivo deste artigo é analisar a visão de Colin Michael Hall acerca do Turismo. Como metas intermediárias pretende-se, a partir da compilação de informações sobre sua vida acadêmica e suas principais contribuições realizar uma breve crítica. Para o trabalho utilizou-se a pesquisa bibliográfica, e entrevista com o autor. Como resultado obteve-se uma reunião das principais ideias e posições ideológicas do autor, e algumas de suas contribuições com o estudo do turismo.

  4. Mechanical Behavior of Additive Manufactured Layered Materials, Part 2: Stainless Steels

    Science.gov (United States)

    2015-04-30

    materials. Elsevier, Oxford; 2007: 416 -420. [19] Deng, D., Chen, R., Sun, Q. and Li, X. Microstructural study of 17-4PH stainless steel after plasma...1 Mechanical Behavior of Additive Manufactured Layered Materials, Part 2: Stainless Steels * Todd M. Mower † and Michael J. Long M.I.T. Lincoln... stainless steel alloys produced with Direct Metal Laser Sintering (DMLS) was measured and is compared to that of similar conventional materials

  5. Invited Commentary: Continuing to Loosen the Constraints on Epidemiology in an Age of Change-A Comment on McMichael's "Prisoners of the Proximate".

    Science.gov (United States)

    Galea, Sandro

    2017-06-01

    Published in 1999, McMichael's "Prisoners of the Proximate: Loosening the Constraints on Epidemiology in an Age of Change" (Am J Epidemiol. 1999;149(10):887-897) outlined an exciting vision for epidemiology as the field that that can help us better understand the drivers of population health so that we may intervene, paving the way for healthier populations. McMichael's paper remains today what it was when it was first published: clear, thoughtful, provocative, and usefully prescriptive in its call to action. McMichael identified 4 constraints facing epidemiology. The field has risen to this challenge and addressed some of these constraints. I discuss how successful (or not) we have been in addressing each of these 4 challenges. © The Author 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  6. Efecto de la Adición de dos Tipos de Almidones en las Propiedades Texturales de Queso Análogo / Effect of the Addition of Two Types of Starch in the Textural Properties of Analogue Cheese

    Directory of Open Access Journals (Sweden)

    Jacqueline Agudelo Chaparro

    2014-12-01

    Full Text Available Resumen. Se estudió el efecto que tienen dos tipos de almidónmodificado, maíz ceroso y papa, en las propiedades texturalesde un queso análogo con fibra prebiótica soluble. Se elaboraronquesos semiblandos, con humedad de 48%, reemplazando el10% de proteína por los almidones modificados, dando lugar atres tratamientos: Formulación control (FC, formulación maízceroso (FMC y formulación papa (FP. Se observó que la adiciónde los almidones afecta significativamente (P<0,05 la dureza, laadhesividad, la gomosidad, la elasticidad y la masticabilidad delproducto. /  Abstract. The effect they have two types of modified starch (waxycorn and potato in the textural properties of an analogue cheesewas studied. Semi-soft cheeses were made with 48% moisture,replacing the 10% protein by modified starches, resulting in threetreatments: Control formulation (CF, waxy corn formulation(WCF and potato formulation (PF. The study allowed note thatthe addition of starches significantly affect (P<0.05 the hardness,adhesiveness, gumminess, elasticity and chewiness of the product

  7. Sewage sludge additive

    Science.gov (United States)

    Kalvinskas, J. J.; Mueller, W. A.; Ingham, J. D. (Inventor)

    1980-01-01

    The additive is for a raw sewage treatment process of the type where settling tanks are used for the purpose of permitting the suspended matter in the raw sewage to be settled as well as to permit adsorption of the dissolved contaminants in the water of the sewage. The sludge, which settles down to the bottom of the settling tank is extracted, pyrolyzed and activated to form activated carbon and ash which is mixed with the sewage prior to its introduction into the settling tank. The sludge does not provide all of the activated carbon and ash required for adequate treatment of the raw sewage. It is necessary to add carbon to the process and instead of expensive commercial carbon, coal is used to provide the carbon supplement.

  8. Base-catalyzed tandem Michael/dehydro-Diels-Alder reaction of α,α-dicyanoolefins with electron-deficient 1,3-conjugated enynes: a facile entry to angularly fused polycycles.

    Science.gov (United States)

    Zhang, Mingrui; Zhang, Junliang

    2014-01-07

    Angularly fused carbocyclic frameworks and their heteroatom-substituted analogues exist in many natural products that display a broad and interesting range of biological activities. Preparation of polycyclic products by cycloaddition reactions have been the long-standing hot topic in the synthetic community. Dehydro-Diels-Alder (DDA) reactions are one class of dehydropericyclic reactions that are derived conceptually by systematic removal of hydrogen atom pairs. A base-promoted tandem Michael addition and DDA reaction of α,α-dicyanoolefins with electron-deficient 1,3-conjugated enynes was realized in which a DDA reaction takes place between the arylalkynes and electron-deficient tetrasubstituted olefin. The control experiments support the stepwise anionic reaction pathway rather than the concerted reaction pathway. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Switchable Diastereoselectivity in the Fluoride Promoted Vinylogous Mukaiyama-Michael Reaction of 2-Trimethylsilyloxyfuran Catalyzed by Crown Ethers

    KAUST Repository

    Della Sala, Giorgio

    2017-05-31

    The fluoride promoted vinylogous Mukaiyama-Michael reaction (VMMR) of 2-trimethylsilyloxyfuran with diverse α,β-unsaturated ketones is described. The TBAF catalyzed VMMR afforded high anti-diastereoselectivity irrespective of the solvents used. The KF/crown ethers catalytic systems proved to be highly efficient in terms of yields and resulted in a highly diastereoselective unprecedented solvent/catalyst switchable reaction. Anti-adducts were obtained as single diastereomers or with excellent diastereoselectivities when benzo-15-crown-5 in CH2Cl2 was employed. On the other hand, high syn-diastereoselectivities (from 76:24 to 96:4) were achieved by employing dicyclohexane-18-crown-6 in toluene. Based on DFT calculations, the catalysts/solvents-dependent switchable diastereoselectivities are proposed to be the result of loose or tight cation-dienolate ion pairs.

  10. Analysis of the Competitive Potential of Bioethanol in Colombia: An approach from Michael Porter's 5 Competitive Forces

    International Nuclear Information System (INIS)

    Ramirez Velasquez, Alejandro; Montoya R, Ivan Alonso; Montoya Restrepo, Alexandra

    2012-01-01

    The search for alternative energy production and consumption require a look into the industry of biofuels such as bioethanol as an alternative energy to overcome the disadvantages generated by the traditional methods of production and consumption, especially in the political, environmental and social issues and generate competitive advantages compared to other primary energy sources. In the present document, and from the Michael Porter five (5) Forces model is detailed an evaluation of the bioethanol industry as an alternative fuel and is described how attractive or competitive may become the industry today. To achieve this purpose, an evaluation of the competitive forces was proposed to a group of experts, using a Likert scale. Thus, it was evaluated the potential usefulness of the proposal.

  11. WHEN DYLAN MET THE BARD: TRANSLATING HAMLET FROM TEXT TO SCREEN (SOUND: MICHAEL ALMEREYDA’S HAMLET

    Directory of Open Access Journals (Sweden)

    Marina Gerzic

    2015-12-01

    Full Text Available Director Michael Almereyda’s diverse musical choices in the film are a threshold into understanding his cinematic interpretation of Hamlet (2000. Almereyda recontextualises Hamlet in terms of contemporary social problems. Hamlet and Ophelia are confronted with and battle against urban claustrophobia, conspiracy and global corporate power. A fragment of the Bob Dylan song ‘All Along the Watchtower’ (1966 is used as a filmic shortcut to translate Shakespeare’s iconic ‘gravedigger scene’ between Hamlet and the Gravedigger from playtext to screen. ‘All Along the Watchtower’ encapsulates certain ideas about mortality and the worth of life from the ‘gravedigger scene’ and demonstrates these issues still resonate in the contemporary urban world the film is set.

  12. QCD propagators and vertices from lattice QCD (in memory of Michael Müller-Preußker

    Directory of Open Access Journals (Sweden)

    Sternbeck André

    2017-01-01

    Full Text Available We review lattice calculations of the elementary Greens functions of QCD with a special emphasis on the Landau gauge. These lattice results have been of interest to continuum approaches to QCD over the past 20 years. They are used as reference for Dyson-Schwinger- and functional renormalization group equation calculations as well as for hadronic bound state equations. The lattice provides low-energy data for propagators and three-point vertices in Landau gauge at zero and finite temperature even including dynamical fermions. We summarize Michael Müller-Preußker’s important contributions to this field and put them into the perspective of his other research interests.

  13. ‘Introducing Michael Gove to Loïc Wacquant’: Why Social Work Needs Critical Sociology

    Science.gov (United States)

    Michael Garrett, Paul

    2016-01-01

    In 2013, Michael Gove, then Secretary of State for Education and Health in the UK coalition government, criticised social workers for laying insufficient emphasis on the ‘agency’ of individuals and for being too preoccupied with social and economic inequalities. Such a perspective, which is not unique to Gove, needs to be countered by reaffirming the significance of an expansively critical sociology for social work. In this context, the thematic concerns of the French theorist, Loïc Wacquant, illuminates key aspects of social work engagement with clients which Gove and his ideological associates appear intent on ignoring. The issues raised have significant political resonances given the pending UK General Election taking place in May 2015. PMID:27559203

  14. Regio- and stereoselective 1,2-dihydropyridine alkylation/addition sequence for the synthesis of piperidines with quaternary centers.

    Science.gov (United States)

    Duttwyler, Simon; Chen, Shuming; Lu, Colin; Mercado, Brandon Q; Bergman, Robert G; Ellman, Jonathan A

    2014-04-07

    The first example of C alkylation of 1,2-dihydropyridines with alkyl triflates and Michael acceptors was developed to introduce quaternary carbon centers with high regio- and diastereoselectivity. Hydride or carbon nucleophile addition to the resultant iminium ion also proceeded with high diastereoselectivity. Carbon nucleophile addition results in an unprecedented level of substitution to provide piperidine rings with adjacent tetrasubstituted carbon atoms. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. 76 FR 55904 - Michael J. Donahue; Notice of Termination of Exemption By Implied Surrender and Soliciting...

    Science.gov (United States)

    2011-09-09

    .... Donahue; Notice of Termination of Exemption By Implied Surrender and Soliciting Comments, Protests, and... Commission: a. Type of Proceeding: Termination of exemption by implied surrender. b. Project No.: 6649-008. c... Commission reserves the right to revoke an exemption if any term or condition of the exemption is violated...

  16. 76 FR 58264 - Michael J. Donahue; Notice of Termination of Exemption by Implied Surrender and Soliciting...

    Science.gov (United States)

    2011-09-20

    .... Donahue; Notice of Termination of Exemption by Implied Surrender and Soliciting Comments, Protests, and... Commission: a. Type of Proceeding: Termination of exemption by implied surrender. b. Project No.: 6649-008. c... Commission reserves the right to revoke an exemption if any term or condition of the exemption is violated...

  17. Minas-type fresh cheese developed from buffalo milk with addition of L. acidophilus Desenvolvimento de queijo minas frescal de leite de búfala com adição de L. acidophilus

    Directory of Open Access Journals (Sweden)

    Bruna Marcatti

    2009-08-01

    Full Text Available Effective incorporation of a probiotic into foods requires the culture to remain viable all along processing and storage, without adverse alterations to sensory characteristics. The objective of this work was developing Minas-type fresh cheese with probiotic properties from buffalo milk. Four batches of Minas-type fresh cheese were prepared using buffalo milk: batch T1 in which neither culture nor lactic acid added; batch T3 in which only lactic acid added; batches T2 and T4 , both added of Lactobacillus acidophilus LAC 4, but T4 was also acidified. Resulting cheeses were evaluated for probiotic culture stability, texture profile, sensory acceptance, and changes in pH. The T4 probiotic cheese presented hardness, gumminess, and chewiness significantly lower than the other treatments. However, values for springiness and cohesiveness did not differ between all cheeses, and no sensory differences (p > 0.05 were found between treatments for texture, taste, and overall acceptance. The addition of probiotic to the acidified cheese (T4 yielded best aroma. The populations of L. acidophilus were greater than 10(6 CFU g-1 after 28 days of storage all products. Minas-type fresh cheese from buffalo milk is a suitable food for the delivery of L. acidophilus, since the culture remained viable during the shelf life of the products and did not negative affect analysed parameters.Para incorporação efetiva de probióticos em alimentos é imprescindível que a cultura mantenha-se viável durante todo o processamento e a estocagem e que não ocorram alterações adversas nas características sensoriais do produto. O objetivo deste trabalho foi desenvolver queijo Minas frescal com propriedades probióticas a partir do leite de búfala. Foram avaliados quatro tratamentos (T1 a T4, sendo T1 e T3 controles, sem e com acidificação, respectivamente em T2 e T4 foram adicionados da cultura probiótica Lactobacillus acidophilus (LAC 4, porém T4 foi também acidificado

  18. Ambulatory blood pressure parameters after canrenone addition to existing treatment regimens with maximum tolerated dose of angiotensin-converting enzyme inhibitors/angiotensin II type 1 receptor blockers plus hydrochlorothiazide in uncontrolled hypertensive patients

    Directory of Open Access Journals (Sweden)

    Guasti L

    2017-08-01

    Full Text Available Luigina Guasti,1,* Giovanni Gaudio,2,* Alessandro Lupi,3 Marinella D’Avino,4 Carla Sala,5,6 Amedeo Mugellini,7 Vito Vulpis,8 Salvatore Felis,9 Riccardo Sarzani,10,11 Massimo Vanasia,12 Pamela Maffioli,7 Giuseppe Derosa7 1Research Center on Dyslipidemia, Internal Medicine 1, University of Insubria, Varese, Italy; 2Internal Medicine Division, Ospedale Angelo Bellini, ASST Valle Olona Somma, Varese, Italy; 3Cardiology Unit, ASL VCO Verbania-Domodossola, Verbania, Italy; 4Unit for the Treatment of Arterial Hypertension, Ospedale Cardarelli, Napoli, Italy; 5Department of Clinical Sciences and Community Health, University of Milan, Milano, Italy; 6Cardiovascular Unit, Fondazione IRCCSS Policlinico, Milano, Italy; 7Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; 8Unit for the Diagnosis and Treatment of Arterial Hypertension, Department of Internal Medicine, Policlinico di Bari, Bari, Italy; 9Cardiology Unit, Ospedale Garibaldi, Catania, Italy; 10ESH Center of Hypertension, Internal Medicine and Geriatrics, University Politecnica delle Marche, Ancona, Italy; 11IRCCS-INRCA, Ancona, Italy; 12THERABEL GiEnne Pharma, Milano, Italy *These authors contributed equally to this work Background: Blockade of the renin–angiotensin–aldosterone system is a cornerstone in cardiovascular disease prevention and hypertension treatment. The relevance of ambulatory blood pressure monitoring (ABPM has been widely confirmed for both increasing the accuracy of blood pressure (BP measurements, particularly in pharmacological trials, and focusing on 24 h BP prognostic parameters. The aim of this study was to assess the effects of canrenone addition on ambulatory BP in uncontrolled hypertensive patients already treated with the highest tolerated dose of angiotensin-converting enzyme (ACE inhibitors or angiotensin II type 1 receptor (AT1R antagonists plus hydrochlorothiazide (HCT. Methods: ABPM was performed at baseline and after 3

  19. Aminodisulfides as additives to lubricants

    Energy Technology Data Exchange (ETDEWEB)

    Balin, A.I.; Tarasevich, V.B.; Veretenova, T.N.

    1980-01-01

    A study was carried out and tehcnology developed for producing sulfur-nitrogen containing additives of the type of aminodisulfide by interaction of beta, beta-dichlordialkyl (aryl) disulfides with diethanolamine in a medium of sulfur-diethanolamine. The 2,2'-bis-(diethanol)-dialkyl(aryl) disulfides obtained do not hydrolyze in aqueous soltuions of alkalis, exhibit rather high antiscoring properties and are recommended for tests as active additives of high pressure to SOZH and technological lubricants of the oil and emulsion types.

  20. On Politics and Education Finance: A Bibliography of Joel S. Berke, James W. Guthrie, and Michael W. Kirst. Vance Bibliographies, Public Administration Series: Bibliography P-821.

    Science.gov (United States)

    Quay, Richard H.

    A bibliography of Joel S. Berke, James W. Guthrie, and Michael W. Kirst on politics and educational finance is presented. Specific topics include the following: whether financial support of public schools should be assumed completely by states, school finance policies and practices, school finance reform versus the spending and tax limitation…

  1. LEBANON AFTER THE CEDAR REVOLUTION/ARE KNUDSEN AND MICHAEL KERR (eds; LEBANON: A HISTORY, 600--2011/by WILLIAM HARRIS

    Directory of Open Access Journals (Sweden)

    Franck Salameh

    2013-05-01

    Full Text Available LEBANON AFTER THE CEDAR REVOLUTION, ARE KNUDSEN AND MICHAEL KERR (eds; London: C. Hurst & Company, 2012. 323 pp. $29.95. LEBANON: A HISTORY, 600--2011, WILLIAM HARRIS; Oxford, New York: Oxford University Press, 2012. 360 pp. $34.95.

  2. How "The Right" Continues to "Do Wrong" by Our Young People: Contemporary Reflections on Michael Apple's Analysis of the "Rightist Turn" in Education

    Science.gov (United States)

    McGregor, Glenda

    2018-01-01

    Michael Apple's 2005 article, "Doing Things the 'Right' Way: Legitimating Educational Inequalities in Conservative Times", is a seminal piece of writing that highlights some of his core concerns with the effects of neo-liberal and neo-conservative ideologies on education. Since its publication, this article has incited much debate about…

  3. Domino Aza-Michael-ih-Diels-Alder Reaction to Various 3-Vinyl-1,2,4-triazines: Access to Polysubstituted Tetrahydro-1,6-naphthyridines.

    Science.gov (United States)

    Jouha, Jabrane; Buttard, Floris; Lorion, Magali; Berthonneau, Clément; Khouili, Mostafa; Hiebel, Marie-Aude; Guillaumet, Gérald; Brière, Jean-François; Suzenet, Franck

    2017-09-15

    A straightforward domino aza-Michael-inverse-electron-demand-hetero-Diels-Alder/retro-Diels-Alder reaction between primary and secondary propargylamine derivatives and 3-vinyl-1,2,4-triazines is developed highlighting not only the uniqueness of this dual-heterocyclic platform but also a novel and unprecedented path to polysubstituted tetrahydro-1,6-naphthyridine scaffolds.

  4. Using Our Voices, Losing Our Bodies: Michael Brown, Trayvon Martin, and the Spirit Murders of Black Male Professors in the Academy

    Science.gov (United States)

    Johnson, Lamar; Bryan, Nathaniel

    2017-01-01

    The recent deaths of Michael Brown, Trayvon Martin, and other Black males have generated new civil rights urgencies in Black communities and spirited academic discourses in higher education regarding the educational and social plight of Black males in America. Connecting the deaths of Black males to our lived experiences in the academy, we use a…

  5. Review Article: Yamada, Jeni "Laura: A Case for the Modularity of Language"; Tomasello, Michael "First Verbs: A Case Study of Early Grammatical Development."

    Science.gov (United States)

    Shatz, Marilyn

    1994-01-01

    Jeni Yamada's "Laura" and Michael Tomasello's "First Verbs" continue a tradition of providing useful information on the language ability of individuals in a depth rarely found in multisubject studies; however, these efforts are unusual for case studies in that both take strong theoretical positions on the essence of language and language learning.…

  6. The Impact of Socio-Cultural Differences on Educational Values: A Comparison of the Pedagogy of Michael Oakeshott and John McGahern

    Science.gov (United States)

    Williams, Kevin

    2017-01-01

    The year 2016 marked the tenth anniversary of the death of John McGahern (born 1934), the widely acclaimed Irish author. There is a shared temper of mind and several common strands in the work of McGahern and that of the English philosopher, Michael Oakeshott (1900-1990). Despite the very different cultural environments in which they grew up and…

  7. What's in a Name? That Which We Call a Crisis? A Commentary on Michael Young's Article "Overcoming the Crisis in Curriculum Theory"

    Science.gov (United States)

    Lundgren, Ulf P.

    2015-01-01

    Michael Young's article "Overcoming the crisis in curriculum theory: a knowledge-based approach" ("JCS, 45", 2) is discussed from the starting point that the claimed crisis is constructed from a decisive solution, that is the solution determines what is a crisis. But curriculum research and curriculum theory are in need of…

  8. A designated centre for people with disabilities operated by St Michael's House, Dublin 5

    LENUS (Irish Health Repository)

    Knox, Shane

    2015-01-01

    In November 2013, the Irish Regulator for emergency medical technicians (EMTs) introduced the first mandatory requirement for registrants to demonstrate evidence of continuous professional development (CPD)\\/continuous professional competence (CPC). This qualitative study assessed the experience of practitioners with CPC-related materials provided to them by the Regulator in addition to identifying perceived or encountered practical challenges and suggested improvements six months following introduction of the requirement.

  9. Cadrage, décadrage et recadrage dans Baa Baa Black Sheep : A Jungle Tale de David Malouf et Michael Berkeley Patrimonial Deconstruction and Reconstruction in David Malouf and Michael Berkeley’s Baa Baa Black Sheep : A Jungle Tale

    Directory of Open Access Journals (Sweden)

    Jean-Philippe Héberlé

    2011-11-01

    Full Text Available This article discusses Michael Berkeley’s first opera, Baa Baa Black Sheep: A Jungle Tale. Premiered under the baton of Paul Daniel on July 3rd 1993 at the Cheltenham International Festival of Music, this opera is based on two texts by Rudyard Kipling: The Jungle Books (1894-1895 and “Baa, Baa, Black Sheep” from the short story collection Wee Willie Winkie and Other Stories, first published in 1888. The libretto was penned by the Australian poet, novelist, playwright and librettist, David Malouf. After a brief survey of some of the earliest transpositions of The Jungle Books, I analyse the way David Malouf deals with both texts. “Baa Baa Black Sheep” is used as the central element of his libretto, and episodes and characters from The Jungle Books are incorporated to draw parallelism between the main topics of the two texts. Both Malouf’s endeavour and Berkeley’s, through the music, aims at deconstructing the preposterous oldest transpositions of The Jungle Books and at focusing on the key elements of Kipling’s famous book, notably identity and hybridism, two important themes of colonial and postcolonial literature. The aim of David Malouf and Michael Berkeley is to address an adult audience and show that The Jungle Books are not only aimed at children as Disney’s or Baden Powell’s appropriations of the work could wrongly make us believe.Cet article porte sur Baa Baa Black Sheep: A Jungle Tale, le premier opéra de Michael Berkeley. Créé au Everyman Theatre de Cheltenham le 3 juillet 1993 sous la direction de Paul Daniel, cette œuvre est le fruit de la collaboration entre le compositeur britannique et l’écrivain australien David Malouf. Le livret de Malouf se fonde sur deux récits de Rudyard Kipling : la nouvelle autobiographique “Baa, Baa, Black Sheep” auquel l’opéra doit son nom et The Jungle Books. Après m’être intéressé aux premières transpositions musicales de The Jungle books, je montre comment

  10. Intensive multifactorial treatment modifies the effect of family history of diabetes on glycaemic control in people with Type 2 diabetes: a post hoc analysis of the ADDITION-Denmark randomized controlled trial.

    Science.gov (United States)

    Eliraqi, G M; Vistisen, D; Lauritzen, T; Sandbaek, A; Jørgensen, M E; Faerch, K

    2015-08-01

    To investigate whether intensive multifactorial treatment can reverse the predisposed adverse phenotype of people with Type 2 diabetes who have a family history of diabetes. Data from the randomized controlled trial ADDITION-Denmark were used. A total of 1441 newly diagnosed patients with diabetes (598 with family history of diabetes) were randomized to intensive treatment or routine care. Family history of diabetes was defined as having one parent and/or sibling with diabetes. Linear mixed-effects models were used to assess the changes in risk factors (BMI, waist circumference, blood pressure, lipids and HbA1c ) after 5 years of follow-up in participants with and without a family history of diabetes. An interaction term between family history of diabetes and treatment group was included in the models to test for a modifying effect of the intervention. All analyses were adjusted for age, sex, baseline value of the risk factor and general practice (random effect). At baseline, participants with a family history of diabetes were younger and had a 1.1 mmol/mol (0.1%) higher HbA1c concentration at the time of diagnosis than those without a family history of diabetes. Family history of diabetes modified the effect of the intervention on changes in HbA1c levels. In the group receiving routine care, participants with a family history of diabetes experienced an improvement in HbA1c concentration that was 3.3 mmol/mol (0.3%) lower than the improvement found in those without a family history of diabetes after 5 years of follow-up. In the intensive treatment group, however, there was no difference in HbA1c concentrations between participants with and without a family history of diabetes after 5 years of treatment. Intensive treatment of diabetes may partly remove the adverse effects of family history of diabetes on glycaemic control. The effect of this improvement on long-term diabetic complications warrants further investigation. © 2015 The Authors. Diabetic Medicine

  11. El movimiento como simulacro en el mundo virtual: Michael Betancourt y el arte de la inmediatez. = Movement as simulacrum in the virtual world: Michael Betancourt and the art of immediacy

    Directory of Open Access Journals (Sweden)

    José Manuel García Perera

    2016-05-01

    Full Text Available La creación artística se ha acercado en los últimos tiempos a la imagen mediática que propone Internet, alterando sustancialmente una experiencia estética antes basada en el movimiento del espectador en torno a la obra y definida ahora por pantallas que inducen a la pasividad. El trabajo en vídeo de Michael Betancourt, encuadrado en el denominado arte glitch, ese que se fija en el fallo ocurrido dentro del ámbito digital, ha sido la base para realizar aquí un estudio comparativo entre diferentes concepciones artísticas del movimiento, así como entre un arte pasado y otro actual que permite ver cómo los avances tecnológicos han originado cambios radicales en la naturaleza corpórea, espacial y móvil de la obra. La investigación de Betancourt propone un nuevo arte cinético que, por medio del error, se hace crítico, se mimetiza con el movimiento en tiempo real que la contemporaneidad demanda y destapa el artificio de imágenes que imitan a la realidad como si quisieran sustituirla.In recent times, artistic creation has come closer to the media image proposed by Internet, thus seriously altering an aesthetic experience based before on movement of the viewer around the work and now defined by screens that induce passivity. Michael Betancourt’s video work, part of the so-called glitch art, which focuses on the failure that can occur within the digital realm, has been here the basis for a comparative study between different concepts of movement in art, as well as between a current and a past art, a comparison that allows us to see clearly how technological advances have produced radical changes in the physical, spatial and mobile nature of the artwork. Betancourt’s investigation proposes a new kinetic art that becomes critical through error, mimics the real-time movement that contemporary culture demands, and uncovers the artificiality of images that mimic reality as if they wanted to replace it.

  12. Additive prognostic value of plasma N-terminal pro-brain natriuretic peptide and coronary artery calcification for cardiovascular events and mortality in asymptomatic patients with type 2 diabetes

    DEFF Research Database (Denmark)

    von Scholten, Bernt Johan; Reinhard, Henrik; Hansen, Tine Willum

    2015-01-01

    BACKGROUND: In patients with type 2 diabetes, cardiovascular disease (CVD) is the major cause of morbidity and mortality. We evaluated the combination of NT-proBNP and coronary artery calcium score (CAC) for prediction of combined fatal and non-fatal CVD and mortality in patients with type 2 diab...

  13. Assessment of psychosocial problems in children with type 1 diabetes and their families: the added value of using standardised questionnaires in addition to clinical estimations of nurses and paediatricians

    NARCIS (Netherlands)

    Boogerd, E.A.; Damhuis, A.M.A.; Velden, J.A.M. van der; Steeghs, M.C.C.H.; Noordam, C.; Verhaak, C.M.; Vermaes, I.P.

    2015-01-01

    AIMS AND OBJECTIVES: To investigate the assessment of psychosocial problems in children with type 1 diabetes by means of clinical estimations made by nurses and paediatricians and by using standardised questionnaires. BACKGROUND: Although children with type 1 diabetes and their parents show

  14. Assessment of psychosocial problems in children with type 1 diabetes and their families: The added value of using standardised questionnaires in addition to clinical estimations of nurses and paediatricians

    NARCIS (Netherlands)

    Boogerd, E.A.; Damhuis, A.M.A.; Alfen-van der Velden, A.A.E.M. van; Steeghs, M.C.C.H.; Noordam, C.; Verhaak, C.M.; Vermaes, I.P.R.

    2015-01-01

    Aims and objectives: To investigate the assessment of psychosocial problems in children with type 1 diabetes by means of clinical estimations made by nurses and paediatricians and by using standardised questionnaires. Background Although children with type 1 diabetes and their parents show increased

  15. Influence du type d’addition minérale sur les propriétés de transfert des Bétons AutoPlaçants Influence of the type of mineral admixtures on the transport properties of self compacting concrete

    Directory of Open Access Journals (Sweden)

    Khelafi H.

    2012-09-01

    Full Text Available La formulation des bétons autoplaçants (BAP présente certaines spécificités dont un volume élevé de pâte et une quantité importante d’ajouts minéraux. Ces deux paramètres influencent sensiblement les propriétés de transfert de ces bétons. Dans ce travail, nous avons étudié l’influence de la nature et du pourcentage de plusieurs additions minérales sur certaines propriétés de transfert (la diffusion des ions chlore et la perméabilité au gaz des BAP. Trois différentes additions minérales ont été testées : des fillers calcaires, de la pouzzolane naturelle et des cendres volantes. Ensuite, nous avons cherché une probable relation analytique entre ces propriétés et la résistance à la compression de ces bétons. Au total, douze formulations ont été étudiées, elles couvrent trois différentes classes de résistances (30 MPa, 50 MPa et 70 MPa et quatre types de bétons: un béton ordinaire vibré, un BAP à base de pouzzolanes naturelles, un BAP à base de fillers calcaires et un BAP à base de cendres volantes. Les résultats montrent que la nature de l’addition minérale dans les BAP influe considérablement sur les propriétés de transferts de ces bétons. Après 28, 90 et 360 jours de cure, les BAP contenant de la pouzzolane naturelle représentent des performances très comparables à celles obtenues sur des BAP à base de cendres volantes et bien meilleures que celles obtenues sur des BAP formulés avec du filler calcaire. Indépendamment du type d’addition minérale, les résultats confirment l’existence d’une forte corrélation entre le développement de la résistance à la compression et les propriétés de transferts des BAP. Formulation of self compacting concrete (SCC has some specific characteristics including a high volume of paste and a large amount of mineral admixtures. These two parameters influence significantly the transport properties of SCC. In this work, we studied the influence of

  16. Advanced sampling theory with applications how Michael ‘selected’ Amy

    CERN Document Server

    Singh, Sarjinder

    2003-01-01

    This book is a multi-purpose document. It can be used as a text by teachers, as a reference manual by researchers, and as a practical guide by statisticians. It covers 1165 references from different research journals through almost 1900 citations across 1194 pages, a large number of complete proofs of theorems, important results such as corollaries, and 324 unsolved exercises from several research papers. It includes 159 solved, data-based, real life numerical examples in disciplines such as Agriculture, Demography, Social Science, Applied Economics, Engineering, Medicine, and Survey Sampling. These solved examples are very useful for an understanding of the applications of advanced sampling theory in our daily life and in diverse fields of science. An additional 173 unsolved practical problems are given at the end of the chapters. University and college professors may find these useful when assigning exercises to students. Each exercise gives exposure to several complete research papers for researchers/stude...

  17. A designated centre for people with disabilities operated by St Michael's House, Dublin 3

    LENUS (Irish Health Repository)

    McGrath, Bridget

    2012-01-01

    This study explored registered psychiatric nurses\\' (RPNs\\') interactions and level of empathy towards service users with a diagnosis of borderline personality disorder (BPD). A qualitative approach was used, and 17 RPNs were interviewed using a semistructured interview schedule incorporating the "staff-patient interaction response scale" (SPIRS). Four themes emerged following data analysis: "challenging and difficult," "manipulative, destructive and threatening behaviour," "preying on the vulnerable resulting in splitting staff and other service users," and "boundaries and structure." Additionally, low levels of empathy were evident in the majority of participants\\' responses to the SPIRS. The findings provide further insight on nurses\\' empathy responses and views on caring for service users with BPD and further evidence for the need for training and education for nurses in the care of service users diagnosed with BPD.

  18. Electrochemical One-Electron Oxidation of Low-Generation Polyamidoamine-Type Dendrimers with a 1,4-Phenylenediamine Core

    DEFF Research Database (Denmark)

    Hammerich, Ole; Hansen, Thomas; Thorvildsen, Asbjørn

    2009-01-01

    voltammetry (DPV) in methanol, acetonitrile, dichloromethane, and dimethyl sulfoxide. The dendrimers are more difficult to oxidize than N,N,N',N'-tetramethyl-p-phenylenediamine (TMePD). The oxidation potentials decrease with increasing dendrimer generation up to G0.5, after which the potential is essentially......A series of polyamidoamine (PAMAM)-type dendrimers with a 1,4-phenylenediamine (PD) core is prepared from PD by procedures including Michael addition of methyl acrylate followed by aminolysis with 1,2-ethanediamine. Their one-electron oxidation potentials are determined by differential pulse......,N,N',N'-tetra-n-alkyl-p-phenylenediamines, including a planar arrangement of the atoms linked to the two PD nitrogen atoms. Thus, the effect of chain size on the oxidation potential appears to be caused primarily by a simple electronic effect. The calculations indicate considerable reorientation of the dendrimer side chains on oxidation, presumably...

  19. Dr Michaels® product family (also branded as Soratinex®) versus Methylprednisolone aceponate - a comparative study of the effectiveness for the treatment of plaque psoriasis.

    Science.gov (United States)

    Hercogovấ, J; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Wollina, U; Tirant, M; Novotny, F; Roccia, M G; Maximov, G K; França, K; Lotti, T

    2016-01-01

    As one of the most common dermatologic chronic-recurrent disease, variable therapeutic options are available today for management of psoriasis. Although topical high potency corticosteroids, alone or in association with salicylic acid or vitamin D analogues, are still considered the best treatment, they do not seem to possess the capability for a long-term control of the disease or prevent recurrences, as their side effects are major contraindications for continuative use. The aim of this study was to investigate whether Dr. Michaels® product family is comparable to methylprednisolone aceponate (MPA) as a viable alternative treatment option for the treatment and management of stable chronic plaque psoriasis. Thirty adults (13 male, 17 female, mean age 40 years) with mild to severe stable chronic plaque psoriasis, were included in the study. Patients were advised to treat the lesions of the two sides of their body (left and right) with two different unknown modalities for 8 weeks; the pack of Dr. Michaels® products on the left side (consisting of a cleansing gel, an ointment and a skin conditioner) and a placebo pack on the right side, consisting of a cleansing gel, methylprednisolone ointment and a placebo conditioner. Assessment was done using the Psoriasis Activity Severity Index (PASI) scores before treatment and after 2, 4, 6 and 8 weeks. The results achieved with the Dr. Michaels® (Soratinex®) product family for the treatment of chronic plaque psoriasis were better than the results achieved with methylprednisolone aceponate (MPA), even though quicker resolution was achieved with the steroid with 45% of patients achieving resolution within 8-10 days in comparison to 5-6 weeks in the Dr. Michaels® (Soratinex®) group. Before therapy, the mean PASI score of the LHS in Dr. Michaels® (Soratinex®) group was 13.8±4.1 SD and 14.2±4.2 SD in the RHS methylprednisolone aceponate (MPA) group. After 8 weeks of treatment 62% of the Dr. Michaels® (Soratinex

  20. A designated centre for people with disabilities operated by St Michael's House, Dublin 9

    LENUS (Irish Health Repository)

    Flinn, AM

    2018-02-01

    Diagnosis of Kawasaki Disease (KD) can be challenging due to lack of a diagnostic test, and some children present with ‘incomplete’ KD when not all diagnostic criteria are met. Treatment with intravenous immunoglobulin (IVIG) and aspirin reduces the risk of coronary artery complications. There is sub-group of patients who are resistant to IVIG\\/aspirin therapy and are at increased risk of complications. Recent evidence suggests that additional treatment of this high-risk group with corticosteroids is beneficial in reducing this risk. We examine the treatment and coronary artery outcomes, by retrospective review of medical records, of a cohort of 32 paediatric patients with KD admitted to a single Irish tertiary centre from January 2010-December 2014. Twenty-eight percent of patients (9\\/32) had an incomplete diagnosis of KD; these patients received IVIG later compared to those with a complete KD diagnosis. 15\\/32 (47%) had abnormal echocardiogram findings in the acute phase, 8\\/32 (25%) had echocardiogram abnormalities at 6-week follow-up, and 4\\/32 (12.5%) had persisting abnormalities. This study highlights the potential for adverse outcome in KD, the difficulty in diagnosis in ‘incomplete’ cases, and the need to identify children at higher risk for adverse outcome where adjunctive therapies would be most beneficial.

  1. Additive Manufacturing Infrared Inspection

    Science.gov (United States)

    Gaddy, Darrell; Nettles, Mindy

    2015-01-01

    The Additive Manufacturing Infrared Inspection Task started the development of a real-time dimensional inspection technique and digital quality record for the additive manufacturing process using infrared camera imaging and processing techniques. This project will benefit additive manufacturing by providing real-time inspection of internal geometry that is not currently possible and reduce the time and cost of additive manufactured parts with automated real-time dimensional inspections which deletes post-production inspections.

  2. Nobody Knows My Name: The Masquerade of Mourning in the Early 1980s Artistic Productions of Michael Jackson and Prince

    Directory of Open Access Journals (Sweden)

    Pochmara Anna

    2017-12-01

    Full Text Available The article analyses Michael Jackson’s album Thriller and Prince’s movie Purple Rain. We explore their camp aesthetics and their recasting of the cultural representations of the black male. Jackson’s and Prince’s performative personas are both liberatory and burdened with the received cultural scripts of black masculinity. We claim that their employment of camp is political rather than escapist and depoliticized. Camp serves them as a platform to mourn the cultural displacement of the black male body in a postslavery America. In particular, the two artists distance themselves from the extensive ideological and physical pressures exerted on the black male body in the early 1980s. As a result, their performances are complexly de-Oedipalized. Prince in Purple Rain refuses to assume the patriarchal position of the Father. Analogously, Jackson fashions himself as a Peter Pan-like eternal adolescent who never makes his final identification as either heterosexual or LGBTQ desiring agent. In the coda to the article, we reach beyond the 1980s to explore a more flexible approach to camp in the artistic output of twenty-first-century African American performers of Queercore and Afrofuturist scenes, which were partially enabled by Jackson’s and Prince’s performances.

  3. Sustainable shape memory polymers based on epoxidized natural rubber cured by zinc ferulate via oxa-Michael reaction

    Directory of Open Access Journals (Sweden)

    Xuhui Zhang

    2015-10-01

    Full Text Available Although various shape memory polymers (SMPs or diverse applications have been widely reported, the SMPs based on rubbers have been rarely realized due to the low triggering temperature of rubbers. In another aspect, the SMPs based on sustainable substances are highly desired for the growing shortage in fossil resources. In the present study, we accordingly developed the sustainable SMPs with tunable triggering temperature, based on natural rubber (NR and ferulic acid (FA as the raw materials. Specifically, the SMPs are based on a crosslinked network of epoxidized natural rubber (ENR crosslinked by in situ formed zinc ferulate (ZDF via oxa-Michael reaction. The excellent shape memory effect (SME is found in these SMPs, as evidenced by the high fixity/recovery ratio and the tunable triggering temperature. With the incorporation of natural halloysite nanotubes (HNTs, the stress and recovery rate of the SMPs are found to be tunable, which widens the application of this kind of SMPs. The combination of adoption of sustainable raw materials, and the excellent and tunable SME makes these SMPs potentially useful in many applications, such as various actuators and heat-shrinkable package materials.

  4. Latter-day Mother Irelands: The Role of Women in Michael Collins and The Wind that Shakes the Barley

    Directory of Open Access Journals (Sweden)

    Pilar Villar-Argáiz

    2007-03-01

    Full Text Available Despite the experimental and subversive work of Irish feminist filmmakers such as Pat Murphy and Margo Harkin in the 1980s, as Gerardine Meaney has contended, “the image of woman as Ireland, Ireland as woman, remains powerful and pervasive in the new Irish cinema” (1998: 250. The cinematic convention of representing Ireland through female characters becomes particularly relevant in two recent Irish historical films: Michael Collins (1996, directed and written by Irish Neil Jordan, and The Wind that Shakes the Barley (2006, written by Scottish Paul Laverty and directed by English Ken Loach. In their dealing with themes such as military occupation, colonisation and the heated debate about the Treaty, both films maintain the nationalist rhetoric that represents Ireland as a woman/mother in a direct manner. Over the course of this essay, I shall try to chart the implications of both films’ representations of women, with a view to demonstrating how, even at present, the trope of Mother Ireland continues to be deep in the national unconscious.

  5. ANÁLISIS DEL POTENCIAL COMPETITIVO DEL BIOETANOL EN COLOMBIA: UN ENFOQUE DESDE LAS 5 FUERZAS COMPETITIVAS DE MICHAEL PORTER

    Directory of Open Access Journals (Sweden)

    RAMIREZ VELASQUEZ ALEJANDRO

    2012-11-01

    Full Text Available La búsqueda de alternativas de producción y consumo energético requiere una mirada hacia la industria de los combustibles biológicos como el bioetanol que, como alternativa energética, permita superar los inconvenientes generados por los métodos tradicionales de producción y consumo, en especial en los temas políticos, ambientales y sociales y generar ventajas competitivas frente a otras fuentes primarias de energía. En el presente documento,a partir del modelo de las cinco (5 Fuerzas de Michael Porter, se realiza una evaluación de la industria del bioetanol como combustible alternativo y se expone qué tan atractiva o competitiva puede llegar a ser su industria en la actualidad. Para lograr este propósito, se propone una evaluación de las fuerzas competitivas a un panel de expertos, usando escalas deLikert, para encontrar el potencial de la propuesta.

  6. Quality evaluation of commercially sold table water samples in Michael Okpara University of Agriculture, Umudike, Nigeria and surrounding environments

    Directory of Open Access Journals (Sweden)

    D.O. Okorie

    2015-01-01

    Full Text Available In Michael Okpara University of Agriculture, Umudike, Nigeria (MOUAU and surrounding environments, table water of different brands is commercially hawked by vendors. To the best of our knowledge, there is no scientific documentation on the quality of these water samples. Hence this study which evaluated the quality of different brands of water samples commercially sold in MOUAU and surrounding environments. The physicochemical properties (pH, total dissolved solids (TDS, biochemical oxygen demand (BOD, total hardness, dissolved oxygen, Cl, NO3, ammonium nitrogen (NH3N, turbidity, total suspended solids (TSS, Ca, Mg, Na and K of the water samples as indices of their quality were carried out using standard techniques. Results obtained from this study indicated that most of the chemical constituents of these table water samples commercially sold in Umudike environment conformed to the standards given by the Nigerian Industrial Standard (NIS, World Health Organization (WHO and American Public Health Association (APHA, respectively, while values obtained for ammonium nitrogen in these water samples calls for serious checks on methods of their production and delivery to the end users.

  7. A stale challenge to the philosophy of science: commentary on "Is psychology based on a methodological error?" by Michael Schwarz.

    Science.gov (United States)

    Ruck, Nora; Slunecko, Thomas

    2010-06-01

    In his article "Is psychology based on a methodological error?" and based on a quite convincing empirical basis, Michael Schwarz offers a methodological critique of one of mainstream psychology's key test theoretical axioms, i.e., that of the in principle normal distribution of personality variables. It is characteristic of this paper--and at first seems to be a strength of it--that the author positions his critique within a frame of philosophy of science, particularly positioning himself in the tradition of Karl Popper's critical rationalism. When scrutinizing Schwarz's arguments, however, we find Schwarz's critique profound only as an immanent critique of test theoretical axioms. We raise doubts, however, as to Schwarz's alleged 'challenge' to the philosophy of science because the author not at all seems to be in touch with the state of the art of contemporary philosophy of science. Above all, we question the universalist undercurrent that Schwarz's 'bio-psycho-social model' of human judgment boils down to. In contrast to such position, we close our commentary with a plea for a context- and culture sensitive philosophy of science.

  8. Jan Rak and Michael J. Tannenbaum present the book "High-pT physics in the heavy ion era"

    CERN Multimedia

    2013-01-01

    Thursday 13 June 2013 from 4 p.m. to 5 p.m. in the Library, Bldg. 52 1-052 The book provides an overview of the basic concepts of large transverse momentum particle physics, with a focus on pQCD phenomena. It examines high-pT probes of relativistic heavy-ion collisions and will serve as a handbook for those working on RHIC and LHC data analyses. Starting with an introduction and review of the field, the authors look at basic observables and experimental techniques, concentrating on relativistic particle kinematics, before moving onto a discussion about the origins of high-pT physics. The main features of high-pT physics are placed within a historical context and the authors adopt an experimental outlook, highlighting the most important discoveries leading up to the foundation of modern QCD theory. High-pT physics in the heavy ion era, by Jan Rak and Michael J. Tannenbaum,  Cambridge University Press, 2013, ISBN  9780521190299. *Coffee will be served from 3 p.m.*

  9. General practitioners trained in motivational interviewing can positively affect the attitude to behaviour change in people with type 2 diabetes. One year follow-up of an RCT, ADDITION Denmark

    DEFF Research Database (Denmark)

    Rubak, S.; Sandbaek, A.; Lauritzen, T.

    2009-01-01

    type 2 diabetic patients. The GPs were randomized in two groups, one with and one without MI training. Both groups received training in target-driven intensive treatment of type 2 diabetic patients. The intervention was a 1(1/2)-day residential course in MI with (1/2)-day follow-up twice during...... the first year. The patient data stemmed from previously validated questionnaires. MAIN OUTCOME MEASURES: The Health Care Climates Questionnaire assesses the patient-doctor relationship and type of counselling. The Treatment Self-Regulation Questionnaire assesses the degree to which behaviour tends......%. Patients in the intervention group were significantly more autonomous and motivated in their inclination to change behaviour after one year compared with the patients from the control group. Patients in the intervention group were also significantly more conscious of the importance of controlling...

  10. [Food additives and healthiness].

    Science.gov (United States)

    Heinonen, Marina

    2014-01-01

    Additives are used for improving food structure or preventing its spoilage, for example. Many substances used as additives are also naturally present in food. The safety of additives is evaluated according to commonly agreed principles. If high concentrations of an additive cause adverse health effects for humans, a limit of acceptable daily intake (ADI) is set for it. An additive is a risk only when ADI is exceeded. The healthiness of food is measured on the basis of nutrient density and scientifically proven effects.

  11. The Bases of Chemical Thermodynamics, Volumes 1 and 2 by Michael Graetzel and Pierre Infelta

    Science.gov (United States)

    van Hecke, Gerald R.

    2001-09-01

    calculated and not trying to discuss randomness, which cannot. The second law is introduced via traditional heat engines with arguments as thorough as those of K. G. Denbigh in his classic Chemical Thermodynamics text. However, the authors use quite different examples, which are highly readable. The overworked term "entropy of the universe" has been abandoned in favor of "global entropy", meaning a combination of the system and surroundings. The term works for me. In addition to the Carnot cycle, there are compelling expositions on the Otto, Stirling, and Joule cycles. When discussing chemical reactions, extensive use is made of the extent of reaction concept. In fact a very clever derivation of the temperature dependencies of DrG°, DrH°, and DrS° is offered using the temperature dependency of the extent of reaction. Still on the topic of chemical equilibrium, the authors provide an example (and make the point quite clearly) of how in cases involving simultaneous chemical equilibria, it is quite possible to drive a reaction with a positive DrG° toward completion through the device of coupling the reaction with other favorable reactions. For biochemical systems this is the reason for life. Having (I hope) intrigued the reader of this review to this point, I'd better describe something more of the text. The two volumes would need to be used as companions in the sense that while Volume 1 could be used alone, Volume 2 definitely refers to crucial material contained in Volume 1. The separation into two volumes does seem a bit odd; and in fact, the volumes are continuously numbered. Each volume contains fully worked-out examples pertinent to the material in that volume. The examples, which the authors call problems but that is a stretch, are not the typical three-line, use the formula, plug-and-chug variety, but very elaborate applications of the principles discussed in the text. The examples could be studied on their own, without the benefit of the text. The text proper has

  12. Michael Jäckel, Julia Derra, Cornelia Eck: SchönheitsAnsichten. Geschlechterbilder in Werbeanzeigen und ihre Bewertung. Baden-Baden: Nomos Verlag 2009.

    Directory of Open Access Journals (Sweden)

    Waltraud Posch

    2010-11-01

    Full Text Available Michael Jäckel, Julia Derra, and Cornelia Eck’s cross-generational study answers the question as to which concepts of beauty are presented in magazine advertisements and how recipients react to these concepts. The book provides an important basis for Media Studies and Gender Sociology particularly because it also shows medial constructions of gender that are initially invisible and because it shows gender related illustrations of physicality and beauty.In einer generationenübergreifenden Studie gehen Michael Jäckel, Julia Derra und Cornelia Eck der Frage nach, welche Schönheitsbilder in der Zeitschriftenwerbung präsentiert und wie diese von Rezipient/-innen aufgenommen werden. Das Buch liefert eine wichtige Basis für Medienforschung und Soziologie der Geschlechter, zumal es auch vordergründig nicht sichtbare mediale Konstruktionen von Geschlecht und die geschlechtsbezogene Darstellung von Körperlichkeit und Schönheit aufzeigt.

  13. El pluralismo y la desigualdad educativa en México. La teoría de la justicia de Michael Walzer

    OpenAIRE

    Aguilar-Sahagún, Luis A.

    2003-01-01

    El presente estudio intenta ofrecer elementos de una teoría sobre la justicia que ilumine los graves problemas de la desigualdad educativa en México. Se trata de la propuesta del filósofo estadunidense Michael Walzer, quien con su obra "Esferas de la justicia. Defensas del pluralismo y la igualdad" ha abierto un horizonte que ha fecundado la discusión sobre este concepto en el contexto del llamado debate liberalismo- comunitarismo.

  14. Evaluation Strategy Michael Porter's five forces model of the competitive environment on the dairy industry (Case Study: Amoll Haraz Dvshh dairy company)

    OpenAIRE

    Mohammad Bolorian Tehrani; Faezeh Rahmani

    2016-01-01

    State of competition in an industry depends on five basic forces. Porter's five forces model including bargaining power of customers, bargaining power of suppliers, threat of newcomers to the industry, threat of substitute products is the intensity of rivalry between competitors. Joint strength of these forces determines the ultimate benefit of potentially any industry. The purpose of this study was to evaluate the competitive environment of the dairy industry based on Michael Por...

  15. Enantioselective organocatalyzed Oxa-Michael-Aldol cascade reactions: Construction of chiral 4H-chromenes with a trifluoromethylated tetrasubstituted carbon stereocenter

    KAUST Repository

    Zhang, Jing

    2015-03-13

    The first organocatalytic asymmetric synthesis of 4H-chromenes bearing a trifluoromethylated tetrasubstituted carbon center is presented. Chiral secondary amines promote the oxa-Michael-aldol cascade reaction between alkynals and 2-trifluoroacetylphenols via iminium-allenamine activation to produce pharmaceutically important heterocycles with excellent enantioselectivities. The proposed reaction can be scaled-up easily with maintenance of the excellent enantioselectivity. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Beyond the center: Sciences in Central and Eastern Europe and their histories. An interview with professor Michael Jordan conducted by Jan Surman

    Directory of Open Access Journals (Sweden)

    Michael Gordin

    2016-11-01

    Full Text Available What is special about sciences in Central and Eastern Europe? What are the obstacles for writing histories of science done beyond metropoles? Is this science different than the science in the centers and what makes it so? How imperial are sciences made by representatives of dominant nations compared to non-dominant nations? These are some of the questions touched upon in the interview with Michael Gordin, a leading historian of science from Princeton University.

  17. Aza-Peptidyl Michael Acceptor and Epoxide Inhibitors—Potent and Selective Inhibitors of Schistosoma mansoni and Ixodes ricinus Legumains (Asparaginyl Endopeptidases)

    Czech Academy of Sciences Publication Activity Database

    Ovat, A.; Muindi, F.; Fagan, C.; Brouner, M.; Hansell, E.; Dvořák, J.; Sojka, Daniel; Kopáček, Petr; McKerrow, J. H.; Caffrey, C. R.; Powers, J. C.

    2009-01-01

    Roč. 52, č. 22 (2009), s. 7192-7210 ISSN 0022-2623 R&D Projects: GA ČR GA206/06/0865; GA MŠk(CZ) LC06009 Institutional research plan: CEZ:AV0Z60220518 Keywords : legumain * IrAE * aza-peptide Michael acceptors Subject RIV: EC - Immunology Impact factor: 4.802, year: 2009

  18. General practitioners trained in motivational interviewing can positively affect the attitude to behaviour change in people with type 2 diabetes. One year follow-up of an RCT, ADDITION Denmark

    DEFF Research Database (Denmark)

    Rubak, S.; Sandbaek, A.; Lauritzen, T.

    2009-01-01

    OBJECTIVE: To examine whether training GPs in motivational interviewing (MI) can improve type 2 diabetic patients' (1) understanding of diabetes, (2) beliefs regarding prevention and treatment, and (3) motivation for behaviour change. METHODS: A randomized controlled trial including 65 GPs and 265......%. Patients in the intervention group were significantly more autonomous and motivated in their inclination to change behaviour after one year compared with the patients from the control group. Patients in the intervention group were also significantly more conscious of the importance of controlling...... their diabetes, and had a significantly better understanding of the possibility of preventing complications. CONCLUSION: MI improved type 2 patients' understanding of diabetes, their beliefs regarding treatment aspects, their contemplation on and motivation for behaviour change. Whether our results can...

  19. A small stone column of the altar screen from the treasures of St Archangel Michael's monastery in Prevlaka

    Directory of Open Access Journals (Sweden)

    Crnčević Dejan

    2013-01-01

    Full Text Available Amongst exhibited fragments of carved stone decorations in the monastery of St Archangel Michael in Prevlaka, Boka Kotorska, situated on the ground floor of the monastery's accommodation quarters, there is a segment of stone liturgical furnishings which is, among other things, distinguished by its monumental dimensions, the high level of its craftsmanship, and the important artistic value of its carved decorations. This small stone column was found by chance as a surface-level find on the neighbouring island of St Gavrilo. This stone column is made from a monolithic piece of high- quality, light-grey marble. It is 96 cm in height, 20 cm wide at the front, 18.5 cm wide at the side, and 13cm wide at the rear. These dimensions indicate that the fragment has the form of an elongated hexahedron, with sides of unequal width. Only the front of this stone fragment is marked with relief decorations, comprising a regularly shaped two-part curled sprouting vine. Moving with its undulating rhythm, its arc defines a space in which is located the central motif of the decoration. This comprises the motif of a bud in the form of stylised crinoline flower, composed of two lateral leaves with a pronounced bulge in the middle. These tightly bent lateral leaves with sharp ends, together with the root of the formed shoot, leave an empty space filled with an offshoot in the form of a regularly formed volute. The left lateral side of the stone column is marked by a long but relatively shallow channel, created around its axis, with a width of 7.5 cm. Its rear side is divided by its own height into two vertical fields, of almost the same width - 6 and 7 cm respectively - one slightly elevated compared to the other. The right lateral side of the column is slanted and only lightly sculptured. On the upper surface of the pillar, a relatively shallow circular hole with a small span is visible, intended as a connection point for other segments that would have been placed on

  20. Polylactides in additive biomanufacturing.

    Science.gov (United States)

    Poh, Patrina S P; Chhaya, Mohit P; Wunner, Felix M; De-Juan-Pardo, Elena M; Schilling, Arndt F; Schantz, Jan-Thorsten; van Griensven, Martijn; Hutmacher, Dietmar W

    2016-12-15

    New advanced manufacturing technologies under the alias of additive biomanufacturing allow the design and fabrication of a range of products from pre-operative models, cutting guides and medical devices to scaffolds. The process of printing in 3 dimensions of cells, extracellular matrix (ECM) and biomaterials (bioinks, powders, etc.) to generate in vitro and/or in vivo tissue analogue structures has been termed bioprinting. To further advance in additive biomanufacturing, there are many aspects that we can learn from the wider additive manufacturing (AM) industry, which have progressed tremendously since its introduction into the manufacturing sector. First, this review gives an overview of additive manufacturing and both industry and academia efforts in addressing specific challenges in the AM technologies to drive toward AM-enabled industrial revolution. After which, considerations of poly(lactides) as a biomaterial in additive biomanufacturing are discussed. Challenges in wider additive biomanufacturing field are discussed in terms of (a) biomaterials; (b) computer-aided design, engineering and manufacturing; (c) AM and additive biomanufacturing printers hardware; and (d) system integration. Finally, the outlook for additive biomanufacturing was discussed. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. Delayed entry into first marriage and marital stability: Further evidence on the Becker-Landes-Michael hypothesis

    Directory of Open Access Journals (Sweden)

    Evelyn Lehrer

    2013-09-01

    Full Text Available BACKGROUND In their pioneering research, Becker, Landes, and Michael (1977 found that beyond age 30 there is a positive relationship between women's age at first marriage and marital instability. They interpreted this finding as a "poor-match effect" emerging when the biological clock begins to tick. OBJECTIVE Our objective was to ascertain with more recent data whether or not there is evidence of a poor match effect and if so, whether it is associated with higher marital instability. METHODS We used data on non-Hispanic white women from the 2006-2010 National Surveys of Family Growth (NSFG (N = 3,184. RESULTS We found evidence of the existence of a poor-match effect: women who delay marriage disproportionately make unconventional matches, which are generally associated with high marital instability. We also found, however, that their unions are very solid. Both of these results were consistent with earlier findings for the 1995 and 2002-2003 NSFG cycles. In attempting to explain this puzzle, we proposed and tested competing hypotheses. We found that the destabilizing effects associated with indicators of unconventional matches are also present in marriages contracted late, but are dwarfed by the stabilizing influences associated with higher levels of education and older ages. CONCLUSIONS This paper contributes to our understanding of the determinants of marital instability and the poor match effect by providing a new interpretation for the puzzle described above. COMMENTS Our findings have implications for analyses of changes over time in the extent of positive assortative mating in the marriage market, and for the extensive literature showing that heterogamy in traits that are complementary in the context of marriage is destabilizing -- heterogamous marriages contracted at a late age are likely to be stable.

  2. Additive and polynomial representations

    CERN Document Server

    Krantz, David H; Suppes, Patrick

    1971-01-01

    Additive and Polynomial Representations deals with major representation theorems in which the qualitative structure is reflected as some polynomial function of one or more numerical functions defined on the basic entities. Examples are additive expressions of a single measure (such as the probability of disjoint events being the sum of their probabilities), and additive expressions of two measures (such as the logarithm of momentum being the sum of log mass and log velocity terms). The book describes the three basic procedures of fundamental measurement as the mathematical pivot, as the utiliz

  3. Michael F. Crowley | NREL

    Science.gov (United States)

    Pittsburgh Supercomputing Center, and at The Scripps Research Institute with David Case and Charles Brooks NIH-funded collaboration with Professor Charles L. Brooks III at the University of Michigan Areas of to determine source of twisting in hydrogen bonding patterns. This modeling will help to understand

  4. INTERVIEW WITH MICHAEL WELKER

    African Journals Online (AJOL)

    basic level, you argued that at least two elements are necessary for an utterance to be ... Henco: In light of the question above, how would you describe what you ... books. A broad biblical orientation, the appreciation of the divine Law (with.

  5. Michael Bahl | NREL

    Science.gov (United States)

    theoretical mathematics, Western New England University, Springfield, MA B.S. in computer science, University Prior Work Experience Founder, Mobile Makes Sense Senior IT Specialist, IBM Graduate Teaching Assistant

  6. Michael's Inside Scoop: Genetics

    Science.gov (United States)

    ... Snow, the First Epidemiologist Microbe Multiplication Magic Scientific Poster Session Poisoned Picnic The Energy Equation Flu Season- ... pieces of advice: 1. Follow the basics of good health. You know ’em. Eat healthy , Get plenty ...

  7. Linnade klubi / Michael Bloomberg

    Index Scriptorium Estoniae

    Bloomberg, Michael

    2007-01-01

    New Yorgi linnapea räägib vajadusest suurendada linnadevahelist koostööd. Sündimas on uus globaalne urbanistlik kogukond, milles linnad teevad üksteisega koostööd ühesuguste probleemide kallal, võisteldes samal ajal omavahel globaalsel turul

  8. Michael Seibert | NREL

    Science.gov (United States)

    . Chair, Alcohol Sources and Uses Session, International Solar Energy Society Meeting, 1981. Member Apparatus for Rapid Biohydrogen Phenotypic Screening of Microorganisms Using a Chemochromic Sensor," Biohydrogen Phenotypic Screening of Microorganisms Using a Chemochromic Sensor," U.S. Patent # 6,448,068

  9. Michael York, Pagan Theology

    Directory of Open Access Journals (Sweden)

    Terry GIFFORD

    2004-10-01

    Full Text Available For Christian missionaries the word ‘pagan’ was a pejorative that implied ‘primitive’, either in the sense of devil worship or barren atheism. From this tradition the word has been associated with either the worship of the wrong gods immanent in the natural environment, or of a godless superstition relating to the spirits alive in nature. Of course, Christianity has been adept at incorporating a diversity of pagan beliefs, occasions and rituals into its colonising practice throughout the worl...

  10. Tiheduse kurvid / Michael Sorkin

    Index Scriptorium Estoniae

    Sorkin, Michael

    2007-01-01

    Autor toob välja linnade kasvu mõju maa ökoloogiale. Tema sõnul on demokraatliku linna jaoks kriitiline tihedus linlike vormide ning käitumisviiside tihke kogum ning just tiheduses on vastus jätkusuutlikuks edasi elamiseks meie planeedil

  11. Michael Resch | NREL

    Science.gov (United States)

    applications along with analytical chemistry expertise. From October 2016 to September 2017, Dr. Resch was on Stover Lignin," ACS Sustainable Chemistry and Engineering (2016) "Interrelationships Between ) "Lignin Depolymerization by Fungal Secretomes and a Microbial Sink," Green Chemistry (2016

  12. [Michael Servetus: symphony in ].

    Science.gov (United States)

    Gracia Guillén, Diego

    2004-01-01

    On October 27th 1553, the physician and religious reformer Miguel Servet was burnt at stake. The 450th anniversary of his death took place, therefore, a few months ago. This is a fact which deserves being taken into account, not only because of the importance of the individual, but also, and mainly, because during the last years some important historiographical advances have changed the traditional approach, giving place to a new and more accurate analysis to his life and work. The topic image of Servet spread by the Spanish historiography of the 19th and most of the 20th Centuries has been that of a scientific genius, discoverer of the pulmonary circulation of blood, but also that of a crazy theologian with absurd ideas about some basic Christian dogmas, specially the Holy Trinity. This image is now considered absolutely misleading. The historiography of the complex religious movements of the 16th Century has shown that Servet, far from being a crazy theologian absolutely disconnected of the religious movements of the Century, was instead one of the leaders of an important Christian movement which G. H. Williams called He consecrated all his life to this goal, which also was the reason of his death, always showing an absolute and admirable intellectual and human coherence. To these goals he subdued any other objective, as well as the study and the exercise of medicine. This gives the basis to correctly understand the fact, never explained convincingly until now, why his great scientific discovery, the pulmonary circulation of blood, appeared as a minimal part in the heart of a theological book.

  13. Multidisciplinary management of type 2 diabetes in children and adolescents

    OpenAIRE

    Bowen, Michael E; Rothman, Russell L

    2010-01-01

    Michael E Bowen1,2, Russell L Rothman2,31Veterans Affairs Quality Scholars Fellowship Program, Tennessee Valley Healthcare System, Tennessee Valley Geriatric Research Education Clinical Center, Nashville, TN, USA; 2Division of General Internal Medicine and Public Health, Department of Medicine, 3Vanderbilt Eskind Diabetes Center, Vanderbilt University School of Medicine, Nashville, TN, USAAbstract: Although once considered a disease of adults, the prevalence of type 2 diabetes in youth is inc...

  14. Tim Burton lavastab Batmani muusikali. Placido Domingo palkas "Star Warsi" võluri. MTV muusikaauhindade show'l narriti Michael Jacksonit. Hendrixi põlenud kitarr läheb müüki

    Index Scriptorium Estoniae

    2002-01-01

    Jim Steinman kirjutab muusikat Tim Burtoni 2005. aastal lavale tulevale Batmani muusikalile. Los Angelese ooperimaja juht Domingo palkas George Lucase Wagneri ooperi "Nibelungide sõrmus" eriefektide ettevalmistamiseks. Britney Spears nimetas Michael Jacksonit Millenniumi artistiks.

  15. Food Additives and Hyperkinesis

    Science.gov (United States)

    Wender, Ester H.

    1977-01-01

    The hypothesis that food additives are causally associated with hyperkinesis and learning disabilities in children is reviewed, and available data are summarized. Available from: American Medical Association 535 North Dearborn Street Chicago, Illinois 60610. (JG)

  16. Groups – Additive Notation

    Directory of Open Access Journals (Sweden)

    Coghetto Roland

    2015-06-01

    Full Text Available We translate the articles covering group theory already available in the Mizar Mathematical Library from multiplicative into additive notation. We adapt the works of Wojciech A. Trybulec [41, 42, 43] and Artur Korniłowicz [25].

  17. Groups – Additive Notation

    OpenAIRE

    Coghetto Roland

    2015-01-01

    We translate the articles covering group theory already available in the Mizar Mathematical Library from multiplicative into additive notation. We adapt the works of Wojciech A. Trybulec [41, 42, 43] and Artur Korniłowicz [25].

  18. Study Protocol: The Norfolk Diabetes Prevention Study [NDPS]: a 46 month multi - centre, randomised, controlled parallel group trial of a lifestyle intervention [with or without additional support from lay lifestyle mentors with Type 2 diabetes] to prevent transition to Type 2 diabetes in high risk groups with non - diabetic hyperglycaemia, or impaired fasting glucose.

    Science.gov (United States)

    Pascale, Melanie; Murray, Nikki; Bachmann, Max; Barton, Garry; Clark, Allan; Howe, Amanda; Greaves, Colin; Sampson, Mike

    2017-01-06

    This 7 year NIHR programme [2011-2018] tests the primary hypothesis that the NDPS diet and physical activity intervention will reduce the risk of transition to type 2 diabetes (T2DM) in groups at high risk of Type 2 diabetes. The NDPS programme recognizes the need to reduce intervention costs through group delivery and the use of lay mentors with T2DM, the realities of normal primary care, and the complexity of the current glycaemic categorisation of T2DM risk. NDPS identifies people at highest risk of T2DM on the databases of 135 general practices in the East of England for further screening with ab fasting plasma glucose and glycosylated haemoglobin [HbA1c]. Those with an elevated fasting plasma glucose [impaired fasting glucose or IFG] with or without an elevated HbA1c [non -diabetic hyperglycaemia; NDH] are randomised into three treatment arms: a control arm receiving no trial intervention, an arm receiving an intensive bespoke group-based diet and physical activity intervention, and an arm receiving the same intervention with enhanced support from people with T2DM trained as diabetes prevention mentors [DPM]. The primary end point is cumulative transition rates to T2DM between the two intervention groups, and between each intervention group and the control group at 46 months. Participants with screen detected T2DM are randomized into an equivalent prospective controlled trial with the same intervention and control arms with glycaemic control [HbA1c] at 46 months as the primary end point. Participants with NDH and a normal fasting plasma glucose are randomised into an equivalent prospective controlled intervention trial with follow up for 40 months. The intervention comprises six education sessions for the first 12 weeks and then up to 15 maintenance sessions until intervention end, all delivered in groups, with additional support from a DPM in one treatment arm. The NDPS programme reports in 2018 and will provide trial outcome data for a group delivered

  19. Type Classes for Lightweight Substructural Types

    Directory of Open Access Journals (Sweden)

    Edward Gan

    2015-02-01

    Full Text Available Linear and substructural types are powerful tools, but adding them to standard functional programming languages often means introducing extra annotations and typing machinery. We propose a lightweight substructural type system design that recasts the structural rules of weakening and contraction as type classes; we demonstrate this design in a prototype language, Clamp. Clamp supports polymorphic substructural types as well as an expressive system of mutable references. At the same time, it adds little additional overhead to a standard Damas-Hindley-Milner type system enriched with type classes. We have established type safety for the core model and implemented a type checker with type inference in Haskell.

  20. Alternative additives; Alternative additiver

    Energy Technology Data Exchange (ETDEWEB)

    2007-08-15

    In this project a number of industrial and agricultural waste products have been characterised and evaluated in terms of alkali-getter performance. The intended use is for biomass-fired power stations aiming at reducing corrosion or slagging related problems. The following products have been obtained, characterised and evaluated: 1) Brewery draff 2) Danish de-gassed manure 3) Paper sludge 4) Moulding sand 5) Spent bleaching earth 6) Anorthosite 7) Sand 8) Clay-sludge. Most of the above alternative additive candidates are deemed unsuitable due to insufficient chemical effect and/or expensive requirements for pre-treatment (such as drying and transportation). 3 products were selected for full-scale testing: de-gassed manure, spent bleaching earth and clay slugde. The full scale tests were undertaken at the biomass-fired power stations in Koege, Slagelse and Ensted. Spent bleaching earth (SBE) and clay sludge were the only tested additive candidates that had a proven ability to react with KCl, to thereby reduce Cl-concentrations in deposits, and reduce the deposit flux to superheater tubes. Their performance was shown to nearly as good as commercial additives. De-gassed manure, however, did not evaluate positively due to inhibiting effects of Ca in the manure. Furthermore, de-gassed manure has a high concentration of heavy metals, which imposes a financial burden with regard to proper disposal of the ash by-products. Clay-sludge is a wet clay slurring, and drying and transportation of this product entails substantial costs. Spent bleaching does not require much pre-treatment and is therefore the most promising alternative additive. On the other hand, bleaching earth contains residual plant oil which means that a range of legislation relating to waste combustion comes into play. Not least a waste combustion fee of 330 DKK/tonne. For all alternative (and commercial) additives disposal costs of the increase ash by-products represents a significant cost. This is