WorldWideScience

Sample records for metabolism annual progress

  1. [Regulation of terpene metabolism]. Annual progress report, March 15, 1988--March 14, 1989

    Energy Technology Data Exchange (ETDEWEB)

    Croteau, R.

    1989-12-31

    Progress in understanding of the metabolism of monoterpenes by peppermint and spearmint is recorded including the actions of two key enzymes, geranyl pyrophosphate:limonene cyclase and a UDP-glucose dependent glucosyl transferase; concerning the ultrastructure of oil gland senescence; enzyme subcellular localization; regulation of metabolism; and tissue culture systems.

  2. 1985. Annual progress report

    International Nuclear Information System (INIS)

    1986-01-01

    This annual progress report of the CEA Protection and Nuclear Safety Institut outlines a description of the progress made in each sections of the Institut Research activities of the different departments include: reactor safety analysis, fuel cycle facilities analysis; and associated safety research programs (criticality, sites, transport ...), radioecology and environmental radioprotection techniques; data acquisition on radioactive waste storage sites; radiation effects on man, studies on radioprotection techniques; nuclear material security including security of facilities, security of nuclear material transport, and monitoring of nuclear material management; nuclear facility decommissioning; and finally the public information [fr

  3. [Regulation of terpene metabolism]. Annual progress report, March 15, 1989--March 14, 1990

    Energy Technology Data Exchange (ETDEWEB)

    Croteau, R.

    1989-11-09

    Terpenoid oils, resins, and waxes from plants are important renewable resources. The objective of this project is to understand the regulation of terpenoid metabolism using the monoterpenes (C{sub 10}) as a model. The pathways of monoterpene biosynthesis and catabolism have been established, and the relevant enzymes characterized. Developmental studies relating enzyme levels to terpene accumulation within the oil gland sites of synthesis, and work with bioregulators, indicate that monoterpene production is controlled by terpene cyclases, the enzymes catalyzing the first step of the monoterpene pathway. As the leaf oil glands mature, cyclase levels decline and monoterpene biosynthesis ceases. Yield then decreases as the monoterpenes undergo catabolism by a process involving conversion to a glycoside and transport from the leaf glands to the root. At this site, the terpenoid is oxidatively degraded to acetate that is recycled into other lipid metabolites. During the transition from terpene biosynthesis to catabolism, the oil glands undergo dramatic ultrastructural modification. Degradation of the producing cells results in mixing of previously compartmentized monoterpenes with the catabolic enzymes, ultimately leading to yield decline. This regulatory model is being applied to the formation of other terpenoid classes (C{sub 15} C{sub 20}, C{sub 30}, C{sub 40}) within the oil glands. Preliminary investigations on the formation of sesquiterpenes (C{sub 15}) suggest that the corresponding cyclases may play a lesser role in determining yield of these products, but that compartmentation effects are important. From these studies, a comprehensive scheme for the regulation of terpene metabolism is being constructed. Results from this project wail have important consequences for the yield and composition of terpenoid natural products that can be made available for industrial exploitation.

  4. [Regulation of terpene metabolism]. Annual progress report, March 15, 1990--March 14, 1991

    Energy Technology Data Exchange (ETDEWEB)

    Croteau, R.

    1991-12-31

    During the last grant period, we have completed studies on the key pathways of monoterpene biosynthesis and catabolism in sage and peppermint, and have, by several lines of evidence, deciphered the rate-limiting step of each pathway. We have at least partially purified and characterized the relevant enzymes of each pathway. We have made a strong case, based on analytical, in vivo, and in vitro studies, that terpene accumulation depends upon the balance between biosynthesis and catabolism, and provided supporting evidence that these processes are developmentally-regulated and very closely associated with senescence of the oil glands. Oil gland ontogeny has been characterized at the ultrastructural level. We have exploited foliar-applied bioregulators to delay gland senescence, and have developed tissue explant and cell culture systems to study several elusive aspects of catabolism. We have isolated pure gland cell clusters and localized monoterpene biosynthesis and catabolism within these structures, and have used these preparations as starting materials for the purification to homogeneity of target ``regulatory`` enzymes. We have thus developed the necessary background knowledge, based on a firm understanding of enzymology, as well as the necessary experimental tools for studying the regulation of monoterpene metabolism at the molecular level. Furthermore, we are now in a position to extend our systematic approach to other terpenoid classes (C{sub 15}-C{sub 30}) produced by oil glands.

  5. Annual progress report

    International Nuclear Information System (INIS)

    1976-04-01

    A summary is presented of research progress at the University of Illinois at Urbana, Illinois during the calendar year 1975. Included are listings of personnel, reports on facilities and operations, and a list of publications submitted or published and papers presented during 1975

  6. Annual progress report 1980

    International Nuclear Information System (INIS)

    1981-01-01

    The technical support activities of the IPSN to competent administrations in 1980 has been marked: namely by the authorizations of divergence for 9 units EdF-PWR of 900 MW, the authorization project of creation and extension of reprocessing plant of COGEMA at the Hague UP 2 -800 and the authorization of starting up of the third unit of production of the EURODIF enrichment plant at Tricastin. On the other hand, IPSN has participated at the elaboration of a certain number of legislative and regulation texts relative to the control of nuclear matter, to radioprotection standards and to criteria of safety. For the safety of breeder, the test made at CABRI pile, in the international research program has given confirmation of the validity of theoretical models used in accidents calculations, hypothetical accidents which has allowed to reactualize safety criteria which have to be used for the development of this type of reactor. In worker radioprotection the results obtained in laboratory on the effect of radon, the progress made in personal dosimetry and the action of radioprotection undertaken in uranium mines constitutes a coherent effort. The deep drilling in granit (1000 m) and the experimental associated program which has finished the indispensable scientific data for the future policy in matter of storage of radioactives wastes. IPSN has contributed to progress made in the rules of exploitation of reactors, in the definition of wastes containment -specially at the output of reprocessing plant- in handling machines in hazardeous areas and in the study of environment [fr

  7. 1983. Annual progress report

    International Nuclear Information System (INIS)

    1984-01-01

    A beautiful experiment series for studying high energy excitation structures (10 to 80 MeV), concerning very heavy and asymmetric systems. CEV-Alice contributions to annual report concern Hg and Er high spin energy levels. About reaction mechanisms, the following contributions can be noticed: proton backward emission experiment results of high energy, at 200 MeV, on numerous targets; spectroscopic studies of direct transfer reactions by 18 O with measurement of angular distributions until 0 0 ; many heavy ion experiments around 30 MeV/u concerning the mechanism evolution between 10 and 100 MeV. Pion coherent production experiments have been made this year on energy dependence of the reaction 3 He+ 3 He → 6 Li+π + , considered as an existing model test. Cross section measurement of the elementary reactions (p,π + ) on three targets of very different masses, in a large energy scale and a wide angular domain, have been measured at the Synchrocyclotron. Concerning the nuclear structure in low and medium energy levels, elastic scattering and transfer studies are to be noticed particularly in transition nuclei region. Exotic nuclei rich in neutrons, with medium mass, Fe, Co, Ni, Zn have been studied using the 14 C beam of the Orsay tandem. The radiochemistry group work is essentially centered on actinides study [fr

  8. 1985. Progress annual report

    International Nuclear Information System (INIS)

    1986-06-01

    Tore Supra construction has been vigorously continued. The whole cryogenic system has been entirely delivered. On TFR priority has been given to electron cyclotron resonance heating; but also neutral heating mechanisms, pellet injection, plasma-wall interaction in the presence of pumped limiter, impurity transport and plasma turbulence have been studied and progress on diagnostics have been made. On Petula, with lower hybrid wave, the numerous results on ion heating, current drive, plasma stability in the presence of non-inductive current and on Tore Supra technical problems are important. At last, theoretical and numerical results are concerned with plasma equilibrium macroscopic evolution of plasma, RF heating, plasma instabilities, magnetic islands, turbulence, transport coefficients and spectroscopy [fr

  9. Annual progress report FY 1977

    International Nuclear Information System (INIS)

    Hansen, K.F.; Henry, A.F.

    1977-07-01

    Progress is summarized in a project directed toward development of numerical methods suitable for the computer solution of problems in reactor dynamics and safety. Specific areas of research include methods of integration of the time-dependent diffusion equations by finite difference and finite element methods; representation of reactor properties by various homogenization procedures; application of synthesis methods; and development of response matrix techniques

  10. CEA Annual progress report 1986

    International Nuclear Information System (INIS)

    1987-01-01

    This annual report presents the general organization of the CEA, the international relations and politics in nuclear field, the activities (military application, nuclear applied research, ANDRA (National Agency for Radioactive Waste Management), nuclear safety and protection, fundamental research, applied research other than nuclear), the industrial group; among topics about men and means, the budget execution of the public establishment of research. In annex, the nuclear power plants around the world and the principal legislative texts related to CEA or atomic energy published in 1986 [fr

  11. FY2011 Annual Progress Report for Propulsion Materials

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Patrick B. [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States); Schutte, Carol L. [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States); Gibbs, Jerry L. [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2011-12-01

    Annual Progress Report for Propulsion Materials focusing on enabling and innovative materials technologies that are critical in improving the efficiency of advanced engines by providing enabling materials support for combustion, hybrid, and power electronics development.

  12. Annual Research Progress Report, Fiscal Year 1982,

    Science.gov (United States)

    1982-10-01

    1982 Peters, V.J. The runner and biomechanics. Texas Academy of Family Physicians, San Antonio, TX, 20 Feb 1982. Peters, V.,. Use of peripheral...Bone scanning in Legg-Perthes disease. Annual Michael loke- -Hiran Kite Program, Scottish Rite Hospital, Atlanta, GA, 23-24 Apr 1982. Thomas, S.R

  13. Clinical Investigation Program Annual Progress Report

    Science.gov (United States)

    1993-09-30

    Assisted Cell Sorting (FACS). Data collection is in progress. CPS successfully identified antibody titers for bullous pemphigoid and pemphigus vulgaris ...Status: Completed (4) Title: Determination of Indirect Immunofluorescence Results in Bullous Pemphigoid and Pemphigus (5) Start Date: 1992 (6) Est

  14. Annual Research Progress Report, FY 1980.

    Science.gov (United States)

    1980-10-01

    contamination and was replaced. Stringent sanitary procedures have been incorporated into SOPs. Two mold inhibitors, propionic acid and methyl p-hydroxy...continuing tissue hypoxia and anaerobic metabolism will gradually reduce blood pit, as noted in a number of acute preparations. Acidemia , by lowering

  15. Clinical Investigation Program. Annual Research Progress Report.

    Science.gov (United States)

    1980-09-30

    Annual Meeting, American Academy of Allergy, Atlanta, GA, 16-20 Feb 1980. (C) Mansfield, L.E.: Canine Bronchoconstriction Provoked by Esophageal...Preve.ntion ind Prel iril,ary Re- port of Quantitative Antcpo:tum Cultures. Presented: Cb-GYN Infectious Disease Symposium, Boca R-iton, FL, Dec 1979...protocol - (, Department of Pediatrics - continued Parry, W.H., Madden, W.A.: Bronchoscope Findings in Bacterial Laryngo- tracheobronchitis . PresEnted

  16. Annual Research Progress Report, Fiscal Year 1980

    Science.gov (United States)

    1980-10-01

    Streptococcus faecalis chemi- lumifescence: The importance of metabolism and medium composition. In "Biolmninecence and Chemiluminescence," Academic Press...Biochemical Societies, Floriana Malta, 1-5 Oct 79. (C) Allen, R.C., Hunter, D.J. Streptococcus faecalis chemiluminescence: Evidence for the involvement of...Conference on Phagocytic Leukocytes, Trieste, Italy, 15-18 Sep 80. (C) Hunter, D.J., Allen, R.C. Oxygen-dependent Streptococcus faecalis chemilumin

  17. Annual Research Progress Report, Fiscal Year 1981,

    Science.gov (United States)

    1981-10-01

    count, sperm motility, sperm morphology, sperm viability, seminal prostaglandins, seminal fructose , seminal zinc, seminal gonadotropins. and gonadal...prostaglandins E, prostaglandins F, and various other seminal fluid components such as fructose , zinc, gonadotropins, and gonadal steroids. PROGRESS...UNIT NO: 81/107 TEHCNICAL OBJECTIVES To determine if there is malabsorption in infants in the intensive care nursery after first feedings and if there

  18. FY2016 Lightweight Materials Annual Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2017-10-31

    The Lightweight Materials research and development (R&D) area within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies under development. Research focuses on addressing critical barriers to commercializing lightweight materials for passenger and commercial vehicles. This report describes the progress made on the research and development projects funded by the Lightweight Materials area.

  19. Annual Research Progress Report, Fiscal Year 1982,

    Science.gov (United States)

    1982-10-01

    viability, seminal prostaglandins, seminal fructose , seminal zinc, seminal gonadotropins, and gonadal steroids. Seminal prostaglandin content will be compared...seminal fluid components such as fructose , zinc, gonadotropins, and gonadal steroids. PROGRESS (78 06 - 82 09) Efforts are continuing to obtain a...ASSISTANTS: CPT Richard Meidell, MC CPT James Little, MSC WORY ’NIT NO: 81/107 TECHNICAL OBJECTIVE %; "o Ietermine it there is malabsorption in infants in the

  20. 2010 Annual Progress Report: DOE Hydrogen Program

    Energy Technology Data Exchange (ETDEWEB)

    2011-02-01

    In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

  1. Radiochemistry Division annual progress report : 1990

    International Nuclear Information System (INIS)

    Iyer, R.H.

    1992-01-01

    This progress report provides an account of the research and development activities of the Radiochemistry Division during the year 1990 in the areas of nuclear chemistry, actinide chemistry and spectroscopy. The main area of work in nuclear chemistry is centered around the fission process induced by reactor neutrons, and light and heavy ions on actinides and low Z (Z<80) elements. Actinide chemistry research is concerned mostly with extraction, complexation and separation of actinide ions from aqueous media using a variety of organic reagents under different experimental conditions. Spectroscopic studies include development and optimisation of chemical/analytical methods for separation and determination of trace metallic impurities and rare earths in fuel materials and EPR and microwave studies on several compounds to understand their superconducting, structural and magnetic properties. A list of publications by the scientific staff of the Division during 1990 is also given in the report. (author). 45 figs., 44 tabs

  2. 1999 annual progress report -- Energy conservation team

    Energy Technology Data Exchange (ETDEWEB)

    Chalk, S. (EERE OTT Office of Advanced Automotive Technologies Energy Conversion Team Leader)

    1999-10-19

    This report highlights progress achieved during FY 1999 under the Light-duty Fuels Utilization R and D Program. The program is comprised of two elements: the Advanced Petroleum-Based APB Fuels Program which focused on developing and testing advanced fuels for use with compression-ignition direct-injection (CIDI) engines and fuel cells and the Alternative Fuels Program which focused on Natural gas and natural gas derived fuels. The report contains 17 summaries of industry and National Laboratory projects. Fuel efficient vehicles with very low emissions are essential to meet the challenges of climate change, energy security, and improved air quality. The authors anticipate cooperative efforts with the auto and energy industries to develop new and innovative technologies that will be used to make advanced transportation vehicles that are fuel efficient, clean, and safe.

  3. Radiochemistry Division: annual progress report: 1987

    International Nuclear Information System (INIS)

    1989-01-01

    The progress of Research and Development (R and D) activities during the year 1987 are reported in the form of summaries, which are presented under the headings (1) Actinide Chemistry, (2) Nuclear Chemistry, and (3) Spectroscopy. Microwave absorption studies of the high Tsub(c) oxide superconductor YBa 2 Cu 3 Osub(7-x) using electron paramagnetic resonance techniques are the new feature during the report year. Radioanalytical services and radiation sources in the form of electrodeposited sources or standard soluti ons were also given to the other Divisions, other units of the Department of Atomic Energy, and other organisations in the country. A list of papers by the members of the Division published in various journals and presented at various symposia, conferences etc. is given at the end of the report. (M.G.B.). refs., 51 tabs., 33 figs

  4. Studies in developmental immunogenetics. Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Owen, R D

    1976-05-26

    Progress is reported on studies of genetic regulation, mainly in complex organisms, and with an emphasis on the immune system as a model for developmental analysis and as a tool for following the development of other systems, especially the brain. Results are reported from studies of biochemical genetics, primarily from a developmental viewpoint and with particular regard to defense mechanisms; cellular aspects of the immune system; the area of cancer immunology and cell specificities as related to tumor systems, primarily from an immunogenetic viewpoint and with particular reference to leukemias in the mouse; and the disruptions of genetic control mechanisms in tumor development, especially as approached through the reappearance of fetal antigens associated with tumor development.

  5. Neutron scattering. Annual progress report 1997

    International Nuclear Information System (INIS)

    Allenspach, P.; Boeni, B.; Fischer, P.; Furrer, A.

    1998-02-01

    The present progress report describes the scientific and technical activities obtained by LNS staff members in 1997. It also includes the work performed by external groups at our CRG instruments D1A and IN3 at the ILL Grenoble. Due to the outstanding properties of neutrons and x-rays the research work covered many areas of science and materials research. The highlight of the year 1997 was certainly the production of neutrons at the new spallation neutron source SINQ. From July to November, SINQ was operating for typically two days/week and allowed the commissioning of four instruments at the neutron guide system: - the triple-axis spectrometer Druechal, - the powder diffractometer DMC, - the double-axis diffractometer TOPSI, the polarised triple-axis spectrometer TASP. These instruments are now fully operational and have already been used for condensed matter studies, partly in cooperation with external groups. Five further instruments are in an advanced state, and their commissioning is expected to occur between June and October 1998: - the high-resolution powder diffractometer HRPT, - the single-crystal diffractometer TriCS, - the time-of-flight spectrometer FOCUS, - the reflectometer AMOR, - the neutron optical bench NOB. Together with the small angle neutron scattering facility SANS operated by the spallation source department, all these instruments will be made available to external user groups in the future. (author) figs., tabs., refs

  6. Federal Facility Agreement Annual Progress Report for Fiscal Year 1998

    International Nuclear Information System (INIS)

    Palmer, E.

    1999-01-01

    This FFA Annual Progress Report has been developed to summarize the information for activities performed during the Fiscal Year 1998 (October 1, 1997, to September 30, 1998) and activities planned for Fiscal Year 1999 by U.S. EPA, SCDHEC, and SRS at those units and areas identified for remediation in the Agreement

  7. FY2014 Fuel & Lubricant Technologies Annual Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Stork, Kevin [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2016-02-01

    Annual progress report for Fuel & Lubricant Technologies. The Fuel & Lubricant Technologies Program supports fuels and lubricants research and development (R&D) to provide vehicle manufacturers and users with cost-competitive options that enable high fuel economy with low emissions, and contribute to petroleum displacement.

  8. 2016 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2017-03-09

    The 2016 Annual Progress Report summarizes fiscal year 2016 activities and accomplishments by projects funded by the DOE Hydrogen and Fuel Cells Program. It covers the program areas of hydrogen production; hydrogen delivery; hydrogen storage; fuel cells; manufacturing R&D; technology validation; safety, codes and standards; systems analysis; market transformation; and Small Business Innovation Research projects.

  9. 2013 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2013-12-01

    The 2013 Annual Progress Report summarizes fiscal year 2013 activities and accomplishments by projects funded by the DOE Hydrogen Program. It covers the program areas of hydrogen production and delivery; hydrogen storage; fuel cells; manufacturing; technology validation; safety, codes and standards; market transformation; and systems analysis.

  10. 2015 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-12-23

    The 2015 Annual Progress Report summarizes fiscal year 2015 activities and accomplishments by projects funded by the DOE Hydrogen and Fuel Cells Program. It covers the program areas of hydrogen production; hydrogen delivery; hydrogen storage; fuel cells; manufacturing R&D; technology validation; safety, codes and standards; systems analysis; and market transformation.

  11. 2014 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-11-01

    The 2014 Annual Progress Report summarizes fiscal year 2014 activities and accomplishments by projects funded by the DOE Hydrogen Program. It covers the program areas of hydrogen production and delivery; hydrogen storage; fuel cells; manufacturing; technology validation; safety, codes and standards; market transformation; and systems analysis.

  12. 2011 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

    Energy Technology Data Exchange (ETDEWEB)

    Satyapal, Sunita [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2011-11-01

    The 2011 Annual Progress Report summarizes fiscal year 2011 activities and accomplishments by projects funded by the DOE Hydrogen Program. It covers the program areas of hydrogen production and delivery; hydrogen storage; fuel cells; manufacturing; technology validation; safety, codes and standards; education; market transformation; and systems analysis.

  13. Federal Facility Agreement Annual Progress Report for FY 1998

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, E.

    1999-08-04

    This FFA Annual Progress Report has been developed to summarize the information for activities performed during the Fiscal Year 1998 (October 1, 1997, to September 30, 1998) and activities planned for Fiscal Year 1999 by U.S. EPA, SCDHEC, and SRS at those units and areas identified for remediation in the Agreement.

  14. Progress in Metabolic Engineering of Saccharomyces cerevisiae

    OpenAIRE

    Nevoigt, Elke

    2008-01-01

    Summary: The traditional use of the yeast Saccharomyces cerevisiae in alcoholic fermentation has, over time, resulted in substantial accumulated knowledge concerning genetics, physiology, and biochemistry as well as genetic engineering and fermentation technologies. S. cerevisiae has become a platform organism for developing metabolic engineering strategies, methods, and tools. The current review discusses the relevance of several engineering strategies, such as rational and inverse metabolic...

  15. Nuclear Structure Group annual progress report June 1974 -May 1975

    International Nuclear Information System (INIS)

    1975-06-01

    This is the first annual progress report of the Nuclear Structure Group of the University of Birmingham. The introduction lists the main fields of study of the Group as: polarisation penomena and optical model studies using 3 He and 4 He probes; photonuclear physics; heavy-ion physics; and K- meson physics. The programme is related to particle accelerators at Birmingham, Oxford, Harwell and the Rutherford Laboratory. The body of the report consists of summaries of 38 experiments undertaken by members of the Group. The third section contains 10 notes on instrumentation topics. Appendices contain lists of (a) personnel, (b) papers published or submitted during the period. (U.K.)

  16. Commercial waste treatment program annual progress report for FY 1983

    Energy Technology Data Exchange (ETDEWEB)

    McElroy, J.L.; Burkholder, H.C. (comps.)

    1984-02-01

    This annual report describes progress during FY 1983 relating to technologies under development by the Commercial Waste Treatment Program, including: development of glass waste form and vitrification equipment for high-level wastes (HLW); waste form development and process selection for transuranic (TRU) wastes; pilot-scale operation of a radioactive liquid-fed ceramic melter (LFCM) system for verifying the reliability of the reference HLW treatment proces technology; evaluation of treatment requirements for spent fuel as a waste form; second-generation waste form development for HLW; and vitrification process control and product quality assurance technologies.

  17. Laboratory Directed Research and Development FY 2000 Annual Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Los Alamos National Laboratory

    2001-05-01

    This is the FY00 Annual Progress report for the Laboratory Directed Research and Development (LDRD) Program at Los Alamos National Laboratory. It gives an overview of the LDRD Program, summarizes progress on each project conducted during FY00, characterizes the projects according to their relevance to major funding sources, and provides an index to principal investigators. Project summaries are grouped by LDRD component: Directed Research and Exploratory Research. Within each component, they are further grouped into the ten technical categories: (1) atomic, molecular, optical, and plasma physics, fluids, and beams, (2) bioscience, (3) chemistry, (4) computer science and software engineering, (5) engineering science, (6) geoscience, space science, and astrophysics, (7) instrumentation and diagnostics, (8) materials science, (9) mathematics, simulation, and modeling, and (10) nuclear and particle physics.

  18. Neutron scattering. Annual progress report 1997; Neutronenstreuung. Annual progress report 1997

    Energy Technology Data Exchange (ETDEWEB)

    Allenspach, P.; Boeni, B.; Fischer, P.; Furrer, A. [Eidgenoessische Technische Hochschule, Zurich (Switzerland). Lab. fuer Neutronenstreuung

    1998-02-01

    The present progress report describes the scientific and technical activities obtained by LNS staff members in 1997. It also includes the work performed by external groups at our CRG instruments D1A and IN3 at the ILL Grenoble. Due to the outstanding properties of neutrons and x-rays the research work covered many areas of science and materials research. The highlight of the year 1997 was certainly the production of neutrons at the new spallation neutron source SINQ. From July to November, SINQ was operating for typically two days/week and allowed the commissioning of four instruments at the neutron guide system: - the triple-axis spectrometer Druechal, - the powder diffractometer DMC, - the double-axis diffractometer TOPSI, the polarised triple-axis spectrometer TASP. These instruments are now fully operational and have already been used for condensed matter studies, partly in cooperation with external groups. Five further instruments are in an advanced state, and their commissioning is expected to occur between June and October 1998: - the high-resolution powder diffractometer HRPT, - the single-crystal diffractometer TriCS, - the time-of-flight spectrometer FOCUS, - the reflectometer AMOR, - the neutron optical bench NOB. Together with the small angle neutron scattering facility SANS operated by the spallation source department, all these instruments will be made available to external user groups in the future. (author) figs., tabs., refs.

  19. Metabolic Reprogramming of Immune Cells in Cancer Progression.

    Science.gov (United States)

    Biswas, Subhra K

    2015-09-15

    Immune cells play a key role in host defense against infection and cancer. Upon encountering danger signals, these cells undergo activation leading to a modulation in their immune functions. However, recent studies reveal that immune cells upon activation also show distinct metabolic changes that impact their immune functions. Such metabolic reprogramming and its functional effects are well known for cancer cells. Given that immune cells have emerged as crucial players in cancer progression, it is important to understand whether immune cells also undergo metabolic reprogramming in tumors and how this might affect their contribution in cancer progression. This emerging aspect of tumor-associated immune cells is reviewed here, discussing metabolic reprogramming of different immune cell types, the key pathways involved, and its impact on tumor progression. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. Solar thermal power systems. Annual technical progress report, FY 1979

    Energy Technology Data Exchange (ETDEWEB)

    Braun, Gerald W.

    1980-06-01

    The Solar Thermal Power Systems Program is the key element in the national effort to establish solar thermal conversion technologies within the major sectors of the national energy market. It provides for the development of concentrating mirror/lens heat collection and conversion technologies for both central and dispersed receiver applications to produce electricity, provide heat at its point of use in industrial processes, provide heat and electricity in combination for industrial, commercial, and residential needs, and ultimately, drive processes for production of liquid and gaseous fuels. This report is the second Annual Technical Progress Report for the Solar Thermal Power Systems Program and is structured according to the organization of the Solar Thermal Power Systems Program on September 30, 1979. Emphasis is on the technical progress of the projects rather than on activities and individual contractor efforts. Each project description indicates its place in the Solar Thermal Power Systems Program, a brief history, the significant achievements and real progress during FY 1979, also future project activities as well as anticipated significant achievements are forecast. (WHK)

  1. The progress on researching method and metabolism of positron radiopharmaceutical

    International Nuclear Information System (INIS)

    Gan Hongmei; Qiao Jinping; Kong Aiying; Zhu Lin

    2010-01-01

    Positron radiopharmaceuticals are mainly used for PET studies, which are used in the field of nuclear medicine as tracers in the diagnosis and treatment of many diseases. They have important position and function in the clinical diagnosis and treatment. Metabolism or biotransformation will happen when PET radio-pharmaceuticals enter into the body. Understanding the metabolic fate of radiopharmaceutical probes is essential for an accurate analysis and interpretation of positron emission tomography imaging. The recent research progress on PET radiopharmaceuticals metabolism was reviewed in this paper, including the metabolism characteristics, research methods, analytical techniques and so on. (authors)

  2. Annual report of waste generation and pollution prevention progress, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-09-01

    This Report summarizes the waste generation and pollution prevention activities of the major operational sites in the Department of Energy (DOE). We are witnessing progress in waste reduction from routine operations that are the focus of Department-wide reduction goals set by the Secretary on May 3,1996. The goals require that by the end of 1999, we reduce, recycle, reuse, and otherwise avoid waste generation to achieve a 50 percent reduction over 1993 levels. This Report provides the first measure of our progress in waste reduction and recycling against our 1993 waste generation baseline. While we see progress in reducing waste from our normal operations, we must begin to focus attention on waste generated by cleanup and facilities stabilization activities that are the major functions of the Office of Environmental Management. Reducing the generation of waste is one of the seven principles that I have established for the Office of Environmental Management Ten Year Plan. As part of our vision to complete a major portion of the environmental cleanup at DOE sites over the next ten years, we must utilize the potential of the pollution prevention program to reduce the cost of our cleanup program. We have included the Secretarial goals as part of the performance measures for the Ten Year Plan, and we are committed to implementing pollution prevention ideas. Through the efforts of both Federal and contractor employees, our pollution prevention program has reduced waste and the cost of our operations. I applaud their efforts and look forward to reporting further waste reduction progress in the next annual update of this Report.

  3. Annual report of waste generation and pollution prevention progress, 1994

    International Nuclear Information System (INIS)

    1996-09-01

    This Report summarizes the waste generation and pollution prevention activities of the major operational sites in the Department of Energy (DOE). We are witnessing progress in waste reduction from routine operations that are the focus of Department-wide reduction goals set by the Secretary on May 3,1996. The goals require that by the end of 1999, we reduce, recycle, reuse, and otherwise avoid waste generation to achieve a 50 percent reduction over 1993 levels. This Report provides the first measure of our progress in waste reduction and recycling against our 1993 waste generation baseline. While we see progress in reducing waste from our normal operations, we must begin to focus attention on waste generated by cleanup and facilities stabilization activities that are the major functions of the Office of Environmental Management. Reducing the generation of waste is one of the seven principles that I have established for the Office of Environmental Management Ten Year Plan. As part of our vision to complete a major portion of the environmental cleanup at DOE sites over the next ten years, we must utilize the potential of the pollution prevention program to reduce the cost of our cleanup program. We have included the Secretarial goals as part of the performance measures for the Ten Year Plan, and we are committed to implementing pollution prevention ideas. Through the efforts of both Federal and contractor employees, our pollution prevention program has reduced waste and the cost of our operations. I applaud their efforts and look forward to reporting further waste reduction progress in the next annual update of this Report

  4. FY2014 Energy Storage R&D Annual Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2015-03-01

    The Energy Storage research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for projects focusing on batteries for plug-in electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush. This report describes the progress made on the research and development projects funded by the Energy Storage subprogram in 2014. You can download individual sections at the following website, http://energy.gov/eere/vehicles/downloads/vehicle-technologies-office-2014-energy-storage-rd-annual-report.

  5. Integrated proteomic and metabolic analysis of breast cancer progression.

    Directory of Open Access Journals (Sweden)

    Patrick G Shaw

    Full Text Available One of the most persistent hallmarks of cancer biology is the preference of tumor cells to derive energy through glycolysis as opposed to the more efficient process of oxidative phosphorylation (OXPHOS. However, little is known about the molecular cascades by which oncogenic pathways bring about this metabolic switch. We carried out a quantitative proteomic and metabolic analysis of the MCF10A derived cell line model of breast cancer progression that includes parental cells and derivatives representing three different tumor grades of Ras-driven cancer with a common genetic background. A SILAC (Stable Isotope Labeling by Amino acids in Cell culture labeling strategy was used to quantify protein expression in conjunction with subcellular fractionation to measure dynamic subcellular localization in the nucleus, cytosol and mitochondria. Protein expression and localization across cell lines were compared to cellular metabolic rates as a measure of oxidative phosphorylation (OXPHOS, glycolysis and cellular ATP. Investigation of the metabolic capacity of the four cell lines revealed that cellular OXPHOS decreased with breast cancer progression independently of mitochondrial copy number or electron transport chain protein expression. Furthermore, glycolytic lactate secretion did not increase in accordance with cancer progression and decreasing OXPHOS capacity. However, the relative expression and subcellular enrichment of enzymes critical to lactate and pyruvate metabolism supported the observed extracellular acidification profiles. This analysis of metabolic dysfunction in cancer progression integrated with global protein expression and subcellular localization is a novel and useful technique for determining organelle-specific roles of proteins in disease.

  6. [Regulation of terpene metabolism]. Progress report

    International Nuclear Information System (INIS)

    Croteau, R.

    1986-01-01

    Studies on the regulation of monoterpene metabolism in M. piperita were conducted. All of the steps from the acyclic precursor geranyl pyrophosphate to the various menthol isomers have been demonstrated. The first intermediate to accumulate in vivo is d-pulegone. The emphasis has been on the demonstration, partial purification and characterization of the relevant enzymes in the pathway. The studies on the isopiperitenol dehydrogenase and isopiperitenone isomerase have been completed. We are not studying the endocyclic double-bond reductase (NADPH-dependent) and, based on substrate specificity studies and the previously demonstrated isomerization of cis- isopulegone to pulegone, are now virtually convinced that the major pathway to menthol(s) in peppermint involves reduction of isopiperitenone to isopulegone and isomerication of isopulegone to pulegone. 16 refs., 1 fig

  7. 1993 annual final progress report: July 1992 through June 1993

    Energy Technology Data Exchange (ETDEWEB)

    Rohatgi, A.; Crotty, G.; Chen, Z.; Sana, P.; Salami, J.; Doolittle, A.; Pang, A.; Pham, T. [Georgia Inst. of Tech., Atlanta, GA (United States). School of Electrical and Computer Engineering

    1994-11-01

    This is the first annual report since the Inauguration of the University Center of Excellence for Photovoltaics Research and Development (UCEP) at Georgia Tech. The essential objective of the Center is to improve the fundamental understanding of the science and technology of advanced PV devices and materials, to provide training and enrich the educational experience of students in the field, and to increase US competitiveness by providing guidelines to industry and DOE for achieving cost-effective and high efficiency PV devices. These objectives are to be accomplished through a combination of research and education. This report summarizes the technical accomplishments, including modeling, processing, and characterization of cast multicrystalline silicon solar cells; use of modeling and PCD measurements to develop a road map for progressing toward 20% multicrystalline and 25% single crystalline cells; the development of a novel PECVD SiN/SiO{sub 2} AR coating that also provides good surface passivation; PECVD deposited SiO{sub 2} films with record low S and D{sub it} at the SiO{sub 2}/Si interface; and educational activities and accomplishments.

  8. Reduced Renal Methylarginine Metabolism Protects against Progressive Kidney Damage

    Science.gov (United States)

    Caplin, Ben; Boruc, Olga; Bruce-Cobbold, Claire; Cutillas, Pedro; Dormann, Dirk; Faull, Peter; Grossman, Rebecca C.; Khadayate, Sanjay; Mas, Valeria R.; Nitsch, Dorothea D.; Wang, Zhen; Norman, Jill T.; Wilcox, Christopher S.; Wheeler, David C.; Leiper, James

    2015-01-01

    Nitric oxide (NO) production is diminished in many patients with cardiovascular and renal disease. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NO synthesis, and elevated plasma levels of ADMA are associated with poor outcomes. Dimethylarginine dimethylaminohydrolase-1 (DDAH1) is a methylarginine-metabolizing enzyme that reduces ADMA levels. We reported previously that a DDAH1 gene variant associated with increased renal DDAH1 mRNA transcription and lower plasma ADMA levels, but counterintuitively, a steeper rate of renal function decline. Here, we test the hypothesis that reduced renal-specific ADMA metabolism protects against progressive renal damage. Renal DDAH1 is expressed predominately within the proximal tubule. A novel proximal tubule–specific Ddah1 knockout (Ddah1PT−/−) mouse demonstrated tubular cell accumulation of ADMA and lower NO concentrations, but unaltered plasma ADMA concentrations. Ddah1PT−/− mice were protected from reduced kidney tissue mass, collagen deposition, and profibrotic cytokine expression in two independent renal injury models: folate nephropathy and unilateral ureteric obstruction. Furthermore, a study of two independent kidney transplant cohorts revealed higher levels of human renal allograft methylarginine-metabolizing enzyme gene expression associated with steeper function decline. We also report an association among DDAH1 expression, NO activity, and uromodulin expression supported by data from both animal and human studies, raising the possibility that kidney DDAH1 expression exacerbates renal injury through uromodulin-related mechanisms. Together, these data demonstrate that reduced renal tubular ADMA metabolism protects against progressive kidney function decline. Thus, circulating ADMA may be an imprecise marker of renal methylarginine metabolism, and therapeutic ADMA reduction may even be deleterious to kidney function. PMID:25855779

  9. FY13 Annual Progress Report for SECA Core Technology Program

    Energy Technology Data Exchange (ETDEWEB)

    Stevenson, Jeffry W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Koeppel, Brian J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-01-31

    This progress report covers technical work performed during fiscal year 2013 at PNNL under Field Work Proposal (FWP) 40552. The report highlights and documents technical progress in tasks related to advanced cell and stack component materials development and computational design and simulation.

  10. Gender Differences in Adipocyte Metabolism and Liver Cancer Progression

    Directory of Open Access Journals (Sweden)

    Otto Ka-Wing Cheung

    2016-09-01

    Full Text Available Liver cancer is the third most common cancer type and the second leading cause of deaths in men. Large population studies have demonstrated remarkable gender disparities in the incidence and the cumulative risk of liver cancer. A number of emerging risk factors regarding metabolic alterations associated with obesity, diabetes and dyslipidemia have been ascribed to the progression of non-alcoholic fatty liver diseases (NAFLD and ultimately liver cancer. The deregulation of fat metabolism derived from excessive insulin, glucose and lipid promotes cancer-causing inflammatory signaling and oxidative stress, which eventually triggers the uncontrolled hepatocellular proliferation. This review presents the current standing on the gender differences in body fat compositions and their mechanistic linkage with the development of NAFLD-related liver cancer, with an emphasis on genetic, epigenetic and microRNA control. The potential roles of sex hormones in instructing adipocyte metabolic programs may help unravel the mechanisms underlying gender dimorphism in liver cancer and identify the metabolic targets for disease management.

  11. Metabolic, autophagic, and mitophagic activities in cancer initiation and progression

    Directory of Open Access Journals (Sweden)

    Anita Hjelmeland

    2016-04-01

    Full Text Available Cancer is a complex disease marked by uncontrolled cell growth and invasion. These processes are driven by the accumulation of genetic and epigenetic alterations that promote cancer initiation and progression. Contributing to genome changes are the regulation of oxidative stress and reactive species-induced damage to molecules and organelles. Redox regulation, metabolic plasticity, autophagy, and mitophagy play important and interactive roles in cancer hallmarks including sustained proliferation, activated invasion, and replicative immortality. However, the impact of these processes can differ depending on the signaling pathways altered in cancer, tumor type, tumor stage, and/or the differentiation state. Here, we highlight some of the representative studies on the impact of oxidative and nitrosative activities, mitochondrial bioenergetics, metabolism, and autophagy and mitophagy in the context of tumorigenesis. We discuss the implications of these processes for cellular activities in cancer for anti-cancer-based therapeutics.

  12. 2. Semi-annual progress report 1980, no 17

    International Nuclear Information System (INIS)

    1981-01-01

    This semi-annual report deals with the experimental research carried out at the Departement de Recherche Fondamentale de Grenoble (fission, nuclear spectroscopy, heavy ion reactions, physical metallurgy, magnetism, organic molecules, theoretical chemistry, molecular physical chemistry, cellular biology, vegetal biology) [fr

  13. Annual report of waste generation and pollution prevention progress 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-09-01

    This Annual Report summarizes and highlights waste generation, waste reduction, pollution prevention accomplishments, and cost avoidance for 44 U.S. Department of Energy reporting sites for Calendar Year 1999. This section summarizes Calendar Year 1999 Complex-wide waste generation and pollution prevention accomplishments.

  14. Annual progress report, July 1, 1979-June 30, 1980

    Energy Technology Data Exchange (ETDEWEB)

    1980-01-01

    Research progress is reported for the year 1979-1980. The report is divided into sections dealing individually with the divisions of Biomolecular and Cellular Science, Environmental Biology, and Nuclear Medicine. The sections have been individually entered into EDB. (ACR)

  15. Annual progress report, July 1, 1979-June 30, 1980

    International Nuclear Information System (INIS)

    1980-01-01

    Research progress is reported for the year 1979-1980. The report is divided into sections dealing individually with the divisions of Biomolecular and Cellular Science, Environmental Biology, and Nuclear Medicine. The sections have been individually entered into EDB

  16. Annual report of waste generation and pollution prevention progress 1995

    International Nuclear Information System (INIS)

    1997-02-01

    This fourth Annual Report presents and analyzes 1995 DOE complex-wide waste generation and pollution prevention activities at 40 reporting sites in 25 States, and trends DOE waste generation from 1991 through 1995. DOE has established a 50% reduction goal (relative to the 1993 baseline) for routine operations radioactive and hazardous waste generation, due by December 31, 1999. Routine operations waste generation decreased 37% from 1994 to 1995, and 43% overall from 1993--1995

  17. Annual report of waste generation and pollution prevention progress 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-02-01

    This fourth Annual Report presents and analyzes 1995 DOE complex-wide waste generation and pollution prevention activities at 40 reporting sites in 25 States, and trends DOE waste generation from 1991 through 1995. DOE has established a 50% reduction goal (relative to the 1993 baseline) for routine operations radioactive and hazardous waste generation, due by December 31, 1999. Routine operations waste generation decreased 37% from 1994 to 1995, and 43% overall from 1993--1995.

  18. 10 CFR 905.14 - Does Western require annual IRP progress reports?

    Science.gov (United States)

    2010-01-01

    ... Section 905.14 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Integrated Resource Planning § 905.14 Does Western require annual IRP progress reports? Yes, customers must submit IRP progress... projected goals and implementation schedules, and energy and capacity benefits and renewable energy...

  19. Integral Fast Reactor Program annual progress report, FY 1991

    Energy Technology Data Exchange (ETDEWEB)

    1992-06-01

    This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1991. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R&D.

  20. Integral Fast Reactor Program annual progress report, FY 1991

    Energy Technology Data Exchange (ETDEWEB)

    1992-06-01

    This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1991. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R D.

  1. Integral Fast Reactor Program. Annual progress report, FY 1992

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, M.J.

    1993-06-01

    This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1992. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R&D.

  2. Integral Fast Reactor Program. Annual progress report, FY 1993

    International Nuclear Information System (INIS)

    Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, M.J.

    1994-10-01

    This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1993. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R and D

  3. Integral Fast Reactor Program annual progress report, FY 1991

    International Nuclear Information System (INIS)

    1992-06-01

    This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1991. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R ampersand D

  4. FY2015 Lightweight Materials R&D Annual Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2016-09-30

    The Lightweight Materials research and development (R&D) area within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies under development. Research focuses on addressing critical barriers to commercializing lightweight materials for passenger and commercial vehicles. This report describes the progress made on the research and development projects funded by the Lightweight Materials area.

  5. Integral Fast Reactor Program annual progress report, FY 1994

    International Nuclear Information System (INIS)

    Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, J.J.

    1994-12-01

    This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1994. Technical accomplishments are presented in the following areas of the IFR technology development activities: metal fuel performance; pyroprocess development; safety experiments and analyses; core design development; fuel cycle demonstration; and LMR technology R ampersand D

  6. The Community's research and development programme on decommissioning of nuclear installations. Third annual progress report 1987

    International Nuclear Information System (INIS)

    1988-01-01

    This is the third annual progress report of the European Community's programme (1984-88) of research on the decommissioning of nuclear installations. It shows the status of the programme on 31 December 1987. The third progress report describes the objectives, scope and work programme of the 69 research contracts concluded, as well as the progress of work achieved and the results obtained in 1987

  7. The community's research and development programme on decommissioning of nuclear installations. Fourth annual progress report 1988

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    This is the fourth annual progress report on the European Community's programme (1984-88) of research on the decommissioning of nuclear installations. It shows the status of the programme at 31 December 1988. The fourth progress report describes the objectives, scope and work programme of the 72 research contracts concluded, as well as the progress of work achieved and the results obtained in 1988

  8. Fuel Chemistry Division: annual progress report for 1988

    International Nuclear Information System (INIS)

    Vaidyanathan, S.

    1991-01-01

    The progress report gives the brief descriptions of various activites of the Fuel Chemistry Division of Bhabha Atomic Research Centre, Bombay for the year 1988. The descriptions of activities are arranged under the headings: Fuel Development Chemistry of Actinides, Quality Control of Fuel, and Studies related to Nuclear Material Accounting. At the end of report, a list of publications published in journals and papers presented at various conferences/symposia during 1988 is given. (author). 13 figs., 61 tabs

  9. Annual progress report 1988, operation of the high flux reactor

    International Nuclear Information System (INIS)

    1989-01-01

    In 1988 the High Flux Reactor Petten was routinely operated without any unforeseen event. The availability was 99% of scheduled operation. Utilization of the irradiation positions amounted to 80% of the practical occupation limit. The exploitation pattern comprised nuclear energy deployment, fundamental research with neutrons, and radioisotope production. General activities in support of running irradiation programmes progressed in the normal way. Development activities addressed upgrading of irradiation devices, neutron radiography and neutron capture therapy

  10. FY 2005 Annual Progress Report for the DOE Hydrogen Program

    Energy Technology Data Exchange (ETDEWEB)

    None

    2005-10-01

    In cooperation with industry, academia, national laboratories, and other government agencies, the Department of Energy's Hydrogen Program is advancing the state of hydrogen and fuel cell technologies in support of the President's Hydrogen Fuel Initiative. The initiative seeks to develop hydrogen, fuel cell, and infrastructure technologies needed to make it practical and cost-effective for Americans to choose to use fuel cell vehicles by 2020. Significant progress was made in fiscal year 2005 toward that goal.

  11. High Energy Physics Group. Annual progress report, fiscal year 1983

    International Nuclear Information System (INIS)

    1983-01-01

    Perhaps the most significant progress during the past twelve months of the Hawaii experimental program, aside from publication of results of earlier work, has been the favorable outcome of several important proposals in which a substantial fraction of our group is involved: the Mark II detector as first-up at the SLC, and DUMAND's Stage I approval, both by DOE review panels. When added to Fermilab approval of two neutrino bubble-chamber experiments at the Tevatron, E632 and E646, the major part of the Hawaii experimental program for the next few years is now well determined. Noteworthy in the SLAC/SLC/Mark II effort is the progress made in developing silicon microstrip detectors with microchip readout. Results from the IMB(H) proton decay experiment at the Morton Salt Mine, although not detecting proton decay, set the best lower limit on the proton's lifetime. Similarly the Very High Energy Gamma Ray project is closely linked with DUMAND, at least in principle, since these gammas are expected to arise from pi-zero decay, while the neutrinos come from charged meson decay. Some signal has been seen from Cygnus X-3, and other candidates are being explored. Preparations for upgrading the Fermilab 15' Bubble Chamber have made substantial progress. Sections of the Progress Report are devoted to VAX computer system improvements, other hardware and software improvements, travel in support of physics experiments, publications and other public reports, and last analysis of data still being gleaned from experimental data taken in years past (PEP-14 and E546, E388). High energy physics theoretical research is briefly described

  12. Annual progress report, July 1, 1983-June 30, 1984

    Energy Technology Data Exchange (ETDEWEB)

    1984-01-01

    Research in the Laboratory of Biomolecular and Celluler Sciences deals with proliferation, gene expression and differentiation in normal cells and in cells exposed to pollutants, carcinogens or tumor promoters. The research program of the Laboratory of Environmental Biology presents an integrated approach to studies of the functional interactions of the physical and biotic components of arid land ecosystems. Nuclear Medicine research has focussed on development of positron emission tomography, preparation of short-lived isotopes of oxygen, nitrogen, carbon and fluorine, use of these isotopes to label physiological substrates, tracer studies of cerebral biochemistry and physiology, measurement of regional myocardial fatty acid metabolism and blood flow. (AER)

  13. Annual progress report, July 1, 1983-June 30, 1984

    International Nuclear Information System (INIS)

    1984-01-01

    Research in the Laboratory of Biomolecular and Celluler Sciences deals with proliferation, gene expression and differentiation in normal cells and in cells exposed to pollutants, carcinogens or tumor promoters. The research program of the Laboratory of Environmental Biology presents an integrated approach to studies of the functional interactions of the physical and biotic components of arid land ecosystems. Nuclear Medicine research has focussed on development of positron emission tomography, preparation of short-lived isotopes of oxygen, nitrogen, carbon and fluorine, use of these isotopes to label physiological substrates, tracer studies of cerebral biochemistry and physiology, measurement of regional myocardial fatty acid metabolism and blood flow

  14. The theory of hadronic systems. Annual progress report

    International Nuclear Information System (INIS)

    Gibbs, W.R.

    1993-01-01

    This report briefly discusses progress on the following topics: isospin breaking in the pion-nucleon system; direct capture of pions into deeply bound atomic states; knock out of secondary components in the nucleus; study of the radii of neutron distributions in nuclei; the hadronic double scattering operator; transparency in pion production; asymmetry in pion scattering and charge exchange from polarized nuclei; the mechanism of pion absorption in nuclei; the neutron-proton charge-exchange reaction; modification of the fundamental structure of nucleons in nuclei; and antiproton annihilation in nuclei

  15. Ionization in liquids [annual] progress report, 1993--1994

    International Nuclear Information System (INIS)

    Bakale, G.

    1994-01-01

    Progress in 1993--94 was focused on delineating how ions of the model nonpolar spherical solute Buckminsterfullerene interact differently with various nonpolar solvents than does the ellipsoidal fullerene analog C-70, and exposing a variety of new audiences to the electrophilicity-carcinogenicity relationship in order to obtain fresh insight into this relationship that may lead to elucidation of the role of electrons in carcinogenesis and thereby a better understanding of the biological effects of ionizing radiation. To achieve these goals a new collaboration was established with scientists at Oak Ridge National Lab who have unique facilities to characterize fullerene and its radiolytic products

  16. Wills Plasma Physics Department annual progress report 1982

    International Nuclear Information System (INIS)

    1982-01-01

    Progress in the experimental program using the research tokamak TORTUS is presented. The main thrust of the program is the study of the characteristics of hydromagnetic waves in tokamak plasmas and in the use of such waves in r.f. heating. Work on runaway electron production, on wave propagation in collisional plasmas and on hydromagnetic shock wave studies is reported. Diagnostic techniques and equipment described include a laser interferometer system and techniques based on the observation of resonance fluorescence and near-resonant scattering of a laser beam from atomic species in a plasma

  17. Nuclear structure from radioactive decay. Annual progress report

    International Nuclear Information System (INIS)

    Wood, J.L.

    1982-01-01

    The most exciting development during this year has been the formulation of a unified description of shape coexistence in nuclei. The picture is built on the idea that deformation in nuclei is due to an attractive proton-neutron force acting in the valence shell model space. The excitation of nucleon pairs across closed shells effectively increases the number of valence nucleons, giving rise to a set of coexisting states with larger deformation. The major area of activity is the study of neutron-deficient nuclei around the Z = 82 shell closure, with special emphasis on the levels of the odd-mass Pt, Au, Hg and Tl isotopes. Progress is reported

  18. 2016 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

    Energy Technology Data Exchange (ETDEWEB)

    Satyapal, Sunita [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-02-01

    In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

  19. 2012 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

    Energy Technology Data Exchange (ETDEWEB)

    2012-12-01

    In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

  20. 2015 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

    Energy Technology Data Exchange (ETDEWEB)

    Popovich, Neil

    2015-12-01

    In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

  1. Fatty liver as a risk factor for progression from metabolically healthy to metabolically abnormal in non-overweight individuals.

    Science.gov (United States)

    Hashimoto, Yoshitaka; Hamaguchi, Masahide; Fukuda, Takuya; Ohbora, Akihiro; Kojima, Takao; Fukui, Michiaki

    2017-07-01

    Recent studies identified that metabolically abnormal non-obese phenotype is a risk factor for cardiovascular diseases. However, little is known about risk factor for progression from metabolically healthy non-overweight to metabolically abnormal phenotype. We hypothesized that fatty liver had a clinical impact on progression from metabolically healthy non-overweight to metabolically abnormal phenotype. In this retrospective cohort study, 14,093 Japanese (7557 men and 6736 women), who received the health-checkup program from 2004 to 2012, were enrolled. Overweight and obesity were defined as body mass index 23.0-25.0 and ≥25.0 kg/m 2 . Four metabolic factors (impaired fasting glucose, hypertension, hypertriglyceridemia and low high density lipoprotein-cholesterol concentration) were used for definition of metabolically healthy (less than two factors) or metabolically abnormal (two or more). We divided the participants into three groups: metabolically healthy non-overweight (9755 individuals, men/women = 4290/5465), metabolically healthy overweight (2547 individuals, 1800/747) and metabolically healthy obesity (1791 individuals, 1267/524). Fatty liver was diagnosed by ultrasonography. Over the median follow-up period of 5.3 years, 873 metabolically healthy non-overweight, 512 metabolically healthy overweight and 536 metabolically healthy obesity individuals progressed to metabolically abnormal. The adjusted hazard risks of fatty liver on progression were 1.49 (95% confidence interval 1.20-1.83, p = 0.005) in metabolically healthy non-overweight, 1.37 (1.12-1.66, p = 0.002) in metabolically healthy overweight and 1.38 (1.15-1.66, p overweight individuals.

  2. Comparative Analysis of Yeast Metabolic Network Models Highlights Progress, Opportunities for Metabolic Reconstruction.

    Directory of Open Access Journals (Sweden)

    Benjamin D Heavner

    2015-11-01

    Full Text Available We have compared 12 genome-scale models of the Saccharomyces cerevisiae metabolic network published since 2003 to evaluate progress in reconstruction of the yeast metabolic network. We compared the genomic coverage, overlap of annotated metabolites, predictive ability for single gene essentiality with a selection of model parameters, and biomass production predictions in simulated nutrient-limited conditions. We have also compared pairwise gene knockout essentiality predictions for 10 of these models. We found that varying approaches to model scope and annotation reflected the involvement of multiple research groups in model development; that single-gene essentiality predictions were affected by simulated medium, objective function, and the reference list of essential genes; and that predictive ability for single-gene essentiality did not correlate well with predictive ability for our reference list of synthetic lethal gene interactions (R = 0.159. We conclude that the reconstruction of the yeast metabolic network is indeed gradually improving through the iterative process of model development, and there remains great opportunity for advancing our understanding of biology through continued efforts to reconstruct the full biochemical reaction network that constitutes yeast metabolism. Additionally, we suggest that there is opportunity for refining the process of deriving a metabolic model from a metabolic network reconstruction to facilitate mechanistic investigation and discovery. This comparative study lays the groundwork for developing improved tools and formalized methods to quantitatively assess metabolic network reconstructions independently of any particular model application, which will facilitate ongoing efforts to advance our understanding of the relationship between genotype and cellular phenotype.

  3. Annual report of waste generation and pollution prevention progress 1997

    International Nuclear Information System (INIS)

    1998-09-01

    This sixth Annual Report presents and analyzes DOE Complex-wide waste generation and pollution prevention activities at 36 reporting sites from 1993 through 1997. In May 1996, the Secretary of Energy established a 50 percent Complex-Wide Waste Reduction Goal (relative to the 1993 baseline) for routine operations radioactive and hazardous waste generation, to be achieved by December 31, 1999. Excluding sanitary waste, routine operations waste generation increased three percent from 1996 to 1997, and decreased 61 percent overall from 1993 to 1997. DOE has achieved its Complex-Wide Waste Reduction Goals for routine operations based upon a comparison of 1997 waste generation to the 1993 baseline. However, it is important to note that increases in low-level radioactive and low-level mixed waste generation could reverse this achievement. From 1996 to 1997, low-level radioactive waste generation increased 10 percent, and low-level mixed waste generation increased slightly. It is critical that DOE sites continue to reduce routine operations waste generation for all waste types, to ensure that DOE's Complex-Wide Waste Reduction Goals are achieved by December 31, 1999

  4. Annual report of waste generation and pollution prevention progress 1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-09-01

    This seventh Annual Report presents and analyzes DOE Complex-wide waste generation and pollution prevention activities at 45 reporting sites from 1993 through 1998. This section summarizes Calendar Year 1998 Complex-wide waste generation and pollution prevention accomplishments. More detailed information follows this section in the body of the Report. In May 1996, the Secretary of Energy established a 50 percent Complex-Wide Waste Reduction Goal (relative to the 1993 baseline) for routine operations radioactive, mixed, and hazardous waste generation, to be achieved by December31, 1999. DOE has achieved its Complex-Wide Waste Reduction Goals for routine operations based upon a comparison of 1998 waste generation to the 1993 baseline. Excluding sanitary waste, routine operations waste generation decreased 67 percent overall from 1993 to 1998. However, for the first time since 1994, the total amount of materials recycled by the Complex decreased from 109,600 metric tons in 1997 to 92,800 metric tons in 1998. This decrease is attributed to the fact that in 1997, several large ''one-time only'' recycling projects were conducted throughout the Complex. In order to demonstrate commitment to DOE's Complex-wide recycling goal, it is important for sites to identify all potential large-scale recycling/reuse opportunities.

  5. Advanced Industrial Materials (AIM) Program: Annual progress report FY 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    In many ways, the Advanced Industrial Materials (AIM) Program underwent a major transformation in Fiscal Year 1995 and these changes have continued to the present. When the Program was established in 1990 as the Advanced Industrial Concepts (AIC) Materials Program, the mission was to conduct applied research and development to bring materials and processing technologies from the knowledge derived from basic research to the maturity required for the end use sectors for commercialization. In 1995, the Office of Industrial Technologies (OIT) made radical changes in structure and procedures. All technology development was directed toward the seven ``Vision Industries`` that use about 80% of industrial energy and generated about 90% of industrial wastes. The mission of AIM has, therefore, changed to ``Support development and commercialization of new or improved materials to improve productivity, product quality, and energy efficiency in the major process industries.`` Though AIM remains essentially a National Laboratory Program, it is essential that each project have industrial partners, including suppliers to, and customers of, the seven industries. Now, well into FY 1996, the transition is nearly complete and the AIM Program remains reasonably healthy and productive, thanks to the superb investigators and Laboratory Program Managers. This Annual Report for FY 1995 contains the technical details of some very remarkable work by the best materials scientists and engineers in the world. Areas covered here are: advanced metals and composites; advanced ceramics and composites; polymers and biobased materials; and new materials and processes.

  6. Annual progress report of the Department of Solid State Physics

    International Nuclear Information System (INIS)

    Als-Nielsen, J.; Skov Pedersen, J.; Lebech, B.

    1992-01-01

    Research in the department covers the field of condensed matter physics. The principal activities of the department are presented in the Progress Report covering the period from 1 January to 31 December 1991. The condensed matter physics research is predominantly experimental utilizing diffraction of neutrons and X-rays. The research topics range from studies of two- and three-dimensional structures, magnetic ordering, heavy femions, high T c superconductivity, phase transitions in model systems to studies of precipitation phenomena and nano-scale structures in various materials. The major interest of the department is in basic research, but projects of more applied nature are often taken up, prompted by the applicability of the developed technique and expertise. (au) 2 tabs., 94 ills., 82 refs

  7. FY2016 Advanced Batteries R&D Annual Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2017-08-31

    The Advanced Batteries research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for projects focusing on batteries for plug-in electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush. This report describes the progress made on the research and development projects funded by the Battery subprogram in 2016. This section covers the Vehicle Technologies Office overview; the Battery subprogram R&D overview; Advanced Battery Development project summaries; and Battery Testing, Analysis, and Design project summaries. It also includes the cover and table of contents.

  8. Physics Department. Annual progress report 1 January - 31 December 1990

    International Nuclear Information System (INIS)

    Als-Nielsen, J.; Skov Pedersen, J.; Lebech, B.

    1991-01-01

    Research in the Physics Department covers the field of condensed matter physics. The principal activities of the department are presented in this Progress Report for the period from 1 January to 31 December 1990. The condensed matter physics research is predominantly experimental utilising diffraction of neutrons and X-rays. The research topics range from studies of two- and three-dimensional structures, magnetic ordering, heavy fermions, phase transitions in model systems to studies of texture and recrystallization kinetics with a more applie nature. In the field high T c superconductors neutron and X-ray diffraction are used both for studying the basic mechanism responsible for the superconductivity and in the analysis of the solid state syntheses of the materials. (author) 9 tabs., 79 ills., 104 refs

  9. [Carbon isotope fractionation in plants]: Annual technical progress report

    International Nuclear Information System (INIS)

    O'Leary, M.H.

    1988-01-01

    Plants fractionate carbon isotopes during photosynthesis in ways which reflect photosynthetic pathway and environment. The fractionation is product of contributions from diffusion, carboxylation and other factors which can be understood using models which have been developed in our work. The object of our work is to use this fractionation to learn about the factors which control the efficiency of photosynthesis. Unlike previous studies, we do not rely principally on combustion methods, but instead develop more specific methods with substantially higher resolving power. We have recently developed a new short-term method for studying carbon isotope fractionation which promises to provide a level of detail about temperature, species, and light intensity effects on photosynthesis which has not been available until now. We are studying the isotopic compositions of metabolites (particularly aspartic acid) in C 3 plants in order to determine the role of phosphoenolpyruvate carboxylase in C 3 photosynthesis. We are studying the relative roles of diffusion and carboxylation in nocturnal CO 2 fixation in CAM plants. We are studying the use of isotopic content as an index of water-use efficiency in C 3 plants. We are developing new methods for studying carbon metabolism in plants. 3 refs

  10. Hungry Horse Mitigation : Flathead Lake : Annual Progress Report 2008.

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Barry; Evarts, Les [Confederated Salish and Kootenai Tribes

    2009-08-06

    . Monitoring, for example, includes a spring gillnetting series conducted annually in Flathead Lake and builds on an existing data set initiated in 1981. Monitoring of the experimental kokanee reintroduction was a primary activity of this project between 1992 and 1997. Lake trout, whose high densities have precluded successful mitigation of losses of other species in Flathead Lake, have been monitored since 1996 to measure several biological parameters. Results of this work have utility in determining the population status of this key predator in Flathead Lake. The project has also defined the baseline condition of the Flathead Lake fishery in 1992-1993 and has conducted annual lakewide surveys since 1998. The restoration component of the project has addressed several stream channel, riparian, and fish passage problems, and suppression of non-native fish. The research component of the project began in FY 2000 and measured trophic linkages between M. relicta and other species to assist in predicting the results of our efforts to suppress lake trout. Only Work Element A in the Statement of Work is funded entirely by Hungry Horse Mitigation funds. Additional funds are drawn from other sources to assist in completion of all remaining Work Elements.

  11. Hungry Horse Mitigation : Flathead Lake : Annual Progress Report 2007.

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Barry; Evarts, Les [Confederated Salish and Kootenai Tribes

    2008-12-22

    . Monitoring, for example, includes a spring gillnetting series conducted annually in Flathead Lake and builds on an existing data set initiated in 1981. Monitoring of the experimental kokanee reintroduction was a primary activity of this project between 1992 and 1997. Lake trout, whose high densities have precluded successful mitigation of losses of other species in Flathead Lake, have been monitored since 1996 to measure several biological parameters. Results of this work have utility in determining the population status of this key predator in Flathead Lake. The project has also defined the baseline condition of the Flathead Lake fishery in 1992-1993 and has conducted annual lakewide surveys since 1998. The restoration component of the project has addressed several stream channel, riparian, and fish passage problems, and suppression of non-native fish. The research component of the project began in FY 2000 and measured trophic linkages between M. relicta and other species to assist in predicting the results of our efforts to suppress lake trout. Only Work Element A in the Statement of Work is funded entirely by Hungry Horse Mitigation funds. Additional funds are drawn from other sources to assist in completion of all remaining Work Elements.

  12. Annual report of waste generation and pollution prevention progress 2000 [USDOE] [9th edition

    International Nuclear Information System (INIS)

    None

    2001-01-01

    This ninth edition of the Annual Report of Waste Generation and Pollution Prevention Progress highlights waste reduction, pollution prevention accomplishments, and cost savings/avoidance for the U.S. Department of Energy (DOE) Pollution Prevention Program for Fiscal Year 2000. This edition marks the first time that progress toward meeting the 2005 Pollution Prevention Goals, issued by the Secretary of Energy in November 1999, is being reported. In addition, the Annual Report has a new format, and now contains information on a fiscal year basis, which is consistent with other DOE reports

  13. Annual report of waste generation and pollution prevention progress 2000 [USDOE] [9th edition

    Energy Technology Data Exchange (ETDEWEB)

    None

    2001-06-01

    This ninth edition of the Annual Report of Waste Generation and Pollution Prevention Progress highlights waste reduction, pollution prevention accomplishments, and cost savings/avoidance for the U.S. Department of Energy (DOE) Pollution Prevention Program for Fiscal Year 2000. This edition marks the first time that progress toward meeting the 2005 Pollution Prevention Goals, issued by the Secretary of Energy in November 1999, is being reported. In addition, the Annual Report has a new format, and now contains information on a fiscal year basis, which is consistent with other DOE reports.

  14. Energy Storage Annual Progress Report for FY15

    Energy Technology Data Exchange (ETDEWEB)

    Pesaran, Ahmad [National Renewable Energy Lab. (NREL), Golden, CO (United States); Ban, Chunmei [National Renewable Energy Lab. (NREL), Golden, CO (United States); Cao, Lei [National Renewable Energy Lab. (NREL), Golden, CO (United States); Graf, Peter [National Renewable Energy Lab. (NREL), Golden, CO (United States); Keyser, Matt [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kim, Gi-Heon [National Renewable Energy Lab. (NREL), Golden, CO (United States); Santhanagopalan, Shriram [National Renewable Energy Lab. (NREL), Golden, CO (United States); Saxon, Aron [National Renewable Energy Lab. (NREL), Golden, CO (United States); Shi, Ying [National Renewable Energy Lab. (NREL), Golden, CO (United States); Smith, Kandler [National Renewable Energy Lab. (NREL), Golden, CO (United States); Tenent, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States); Yang, Chuanbo [National Renewable Energy Lab. (NREL), Golden, CO (United States); Zhang, Chao [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-12-01

    The Energy Storage research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for projects focusing on batteries for plug-in electric vehicles (PEVs) in support of the EV Everywhere Grand Challenge. PEVs could have a significant impact on the nation's goal of reducing dependence on imported oil and gaseous pollutant emissions. The Energy Storage program targets overcoming technical barriers to enable market success, including: (1) significantly reducing battery cost; (2) increasing battery performance (power, energy, durability); (3) reducing battery weight and volume; and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush. The National Renewable Energy Laboratory (NREL) supports the VTO's Energy Storage program by evaluating the thermal performance of cells and packs, developing electrochemical-thermal models to accelerate the design cycle for developing batteries, investigating the behavior of lithium-ion batteries under abuse conditions such as crush, enhancing the durability of electrodes by coatings such as atomic layer deposition, synthesis of materials for higher energy density batteries, and conducting techno-economic analysis of batteries in various electric-drive vehicles. This report describes the progress made by NREL on the research and development projects funded by the DOE VTO Energy Storage subprogram in FY15.

  15. Environmental and Occupational Safety Division annual progress report for 1984

    International Nuclear Information System (INIS)

    1985-11-01

    Over 950 radiation workers were monitored at ORNL for both internal and external exposure to ionizing radiation and radioactive materials in 1984, and no employee exceeded 50% of the applicable DOE dose limit. No internal exposure exceeded 10% of the maximum permissible organ burden, as determined by in-vivo gamma spectrometry. Dose readings from 5000 TLDs and 136,000 pocket meters were determined, and more than 5800 calibrations were performed on these devices. Approximately 82,000 radioassays were performed; among these were 1500 urinalyses and 3000 radiochemical analyses. Over 3000 calibrations were performed for approximately 2000 portable and fixed survey instruments. Response teams were identified in support of the Radiological Assistance Program (RAP). Documentation, procedures, and equipment for the RAP vehicle were upgraded. A long-range environmental plan was issued early in the year and again in June 1984 to document the scope and justification for each project. The DEM is developing an environmental information system for managing DOE-ORO and ORNL environmental data. Five hundred eighty-four waste disposal requests containing 5769 items were handled by the Hazardous Materials Control Group during 1984. The Office of Operational Safety made significant progress in the completion of Safety Analysis Reports for existing facilities. The Radiation and Safety Surveys Department is becoming increasingly involved in work resulting in facility improvement, repair, or upgrade as well as decontamination and decommissioning of older facilities

  16. Annual progress report for 1982 of Theoretical Reactor Physics Section

    International Nuclear Information System (INIS)

    Rastogi, B.P.; Kumar, Vinod

    1983-01-01

    The progress of work done in the Theoretical Reactor Physics Section of the Bhabha Atomic Research Centre, Bombay, during the calendar year 1982 is reported in the form of write-ups and summaries. The main thrust of the work has been to master the neutronic design technology of four different types of nuclear reactor types, namely, pressurized heavy water reactors, boiling light water reactors, pressurized light water reactors and fast breeder reactors. The development work for the neutronic analysis, fuel design, and fuel management of the BWR type reactors of the Tarapur Atomic Power Station has been completed. A new reactor simulator system for PHWR design analysis and core follow-up was completed. Three dimensional static analysis codes based on nodal and finite element methods for the design work of larger size (500-750 MWe) reactors have been developed. Space link kinetics codes in one, two and three dimensions for above-mentioned reactor systems have been written and validated. Fast reactor core disruptive analysis codes have been developed. In the course of R and D work concerning various types of reactor projects, investigations were also carried in the allied areas of Monte Carlo techniques, integral transform methods, path integral methods, high spin states in heavy nuclei and a hydrodynamics model for a laser driven fusion system. (M.G.B.)

  17. Physics Department annual progress report 1 January - 31 December 1982

    International Nuclear Information System (INIS)

    1983-09-01

    Research in the Physics Department at Risoe National Laboratory covers three main fields: condensed matter physics, plasma physics and meteorology. The report is a progress report describing the principal activities in these fields for the period from 1 January to 31 December 1982. The condensed matter physics research is predominantly experimental utilising diffraction of neutrons, X-rays, and synchrotron X-ray radiation. The research topics range from studies of structure, excitations and phase transitions in model systems to studies of ion transport, texture and recrystallization kinetics with a more applied nature. The plasma physics research is partly experimental and partly theoretical. A study of pellet-plasma interaction is of applied nature and aimed at assessing the possibilities of refuelling a fusion reactor by shooting deuterium-tritium pellets into the plasma. A study of the fundamental physics of plasmas deals with investigations of wave propagation properties, instabilities, solitons, turbulence, etc. The research and applied work within meteorology lies within micrometereology and the subjects range from surface energy balance studies, over studies of the general structure of atmospheric coherence and boundary layer response to change in surface elevation, to specific studies of turbulent dispersion and deposition of airborne material. As part of the applied work within meteorology and wind energy, the test station for small windmills tests and licences windmills for the Danish market and offers consulting assistance for the Danish windmill manufacturers. (Auth.)

  18. Physics Department. Annual progress report 1 January - 31 December 1989

    International Nuclear Information System (INIS)

    Als-Nielsen, J.; Skov Pedersen, J.; Juul Rasmussen, J.; Lebech, B.

    1990-02-01

    Research in the Physics Department covers two main fields: condensed matter physics and plasma physics. The principal activites in these fields are presented in this Progress Report covering the period from 1 January to 31 December 1989. The condensed matter physics research is predominantly experimental utilising diffraction of neutrons and x-rays. The research topics range from studies of two- and three-dimensional structures, magnetic ordering, heavy fermions, phase transitions in model systems to studies of texture and recrystallization kinetics with a more applied nature. The discovery of the high Tc superconductors in 1986 has opened an important new research area, where neutron and x-ray diffraction are used to elucidate the basic mechanism responsible for the superconductivity and in the analysis of the solid state syntheses used in producing the materials. The plasma physics research is partly experimental and partly theoretical. The plasma physics programme is also of a wide scope ranging from fundamental studies of wave propagation, instabilities, solitons and turbulence in plasmas to refuelling a fusion reactor by deuterium-tritium pellets. (author) 4 tabs., 66 ills., 71 refs

  19. Systems Biology of Metabolism: Annual Review of Biochemistry

    DEFF Research Database (Denmark)

    Nielsen, Jens

    2017-01-01

    Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use mathematical models for holistic studies. The use of mathematical models in biology is referred to as systems biology. In this review, the principles of systems biology......, the application of systems biology for analyzing global regulatory structures, engineering the metabolism of cell factories, and analyzing human diseases is discussed....

  20. Pennsylvania State University Breazeale Nuclear Reactor. Thirtieth annual progress report, July 1, 1984-June 30, 1985

    International Nuclear Information System (INIS)

    Levine, S.H.; Totenbier, R.E.

    1985-08-01

    This report is the thirtieth annual progress report of the Pennsylvania State University Breazeale Nuclear Reactor and covers such topics as: personnel; reactor facility; cobalt-60 facility; education and training; Radionuclear Application Laboratory; Low Level Radiation Monitoring Laboratory; and facility research utilization

  1. Fusion Energy Division annual progress report period ending December 31, 1986

    Energy Technology Data Exchange (ETDEWEB)

    Morgan, O.B. Jr.; Berry, L.A.; Sheffield, J.

    1987-10-01

    This annual report on fusion energy discusses the progress on work in the following main topics: toroidal confinement experiments; atomic physics and plasma diagnostics development; plasma theory and computing; plasma-materials interactions; plasma technology; superconducting magnet development; fusion engineering design center; materials research and development; and neutron transport. (LSP)

  2. Fusion Energy Division annual progress report period ending December 31, 1986

    International Nuclear Information System (INIS)

    Morgan, O.B. Jr.; Berry, L.A.; Sheffield, J.

    1987-10-01

    This annual report on fusion energy discusses the progress on work in the following main topics: toroidal confinement experiments; atomic physics and plasma diagnostics development; plasma theory and computing; plasma-materials interactions; plasma technology; superconducting magnet development; fusion engineering design center; materials research and development; and neutron transport

  3. FY2011 Annual Progress Report for Advanced Combustion Engine Research and Development

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2011-12-01

    Annual Progress Report for the Advanced Combustion Engine Research and Development (R&D) subprogram supporting the mission of the Vehicle Technologies Program by removing the critical technical barriers to commercialization of advanced internal combustion engines (ICEs) for passenger and commercial vehicles that meet future federal emissions regulations.

  4. Kootenai River fisheries investigations: rainbow and bull trout recruitment: annual progress report 1999; ANNUAL

    International Nuclear Information System (INIS)

    Walters, Jody P.; Downs, Christopher Charles

    2001-01-01

    Our 1999 objectives were to determine sources of rainbow trout Oncorhynchus mykiss and bull trout Salvelinus confluentus spawning and recruitment in the Idaho reach of the Kootenai River. We used a rotary-screw trap to capture juvenile trout to determine age at out-migration and to estimate total out-migration from the Boundary Creek drainage to the Kootenai River. The out-migrant estimate for March through August 1999 was 1,574 (95% C. I.= 825-3,283) juvenile rainbow trout. Most juveniles out-migrated at age-2 and age-3. No out-migrating bull trout were caught. Five of 17 rainbow trout radio-tagged in Idaho migrated upstream into Montana waters during the spawning season. Five bull trout originally radio-tagged in O'Brien Creek, Montana in early October moved downstream into Idaho and British Columbia by mid-October. Annual angler exploitation for the rainbow trout population upstream of Bonners Ferry, Idaho was estimated to be 58%. Multi-pass depletion estimates for index reaches of Caboose, Curley, and Debt creeks showed 0.20, 0.01, and 0.13 rainbow trout juveniles/m(sup 2), respectively. We estimated rainbow trout (180-415 mm TL) standing stock of 1.6 kg/ha for the Hemlock Bar reach (29.4 ha) of the Kootenai River, similar to the 1998 estimate. Recruitment of juvenile rainbow and bull trout from Idaho tributaries is not sufficient to be the sole source of subsequent older fish in the mainstem Kootenai River. These populations are at least partly dependent on recruitment from Montana waters. The low recruitment and high exploitation rate may be indicators of a rainbow trout population in danger of further decline

  5. Research progress of electrophysiology for the diagnosis of metabolic myopathy

    Directory of Open Access Journals (Sweden)

    Lei ZHAO

    2014-06-01

    Full Text Available Metabolic myopathies comprise a group of diverse disorders characterized by defects ofn energy metabolism in skeletal muscle cells, including glycogen storage disease (GSD, lipid storage myopathy (LSM and mitochondrial myopathy. The diagnosis of metabolic myopathies is often challenging due to the clinical and etiological heterogeneity between different metabolic myopathies. Generally, the diagnosis of metabolic myopathies is mainly based on the age of onset, family history, clinical manifestation, electrophysiological examinations, serological screening of metabolic markers, muscle biopsy and the DNA testing for specific mutations. The classical electrophysiological diagnostic methods and the corresponding manifestation of metabolic myopathies were reviewed and some new diagnostic techniques, including new motor unit potential (MUP parameters were introduced in this article. doi: 10.3969/j.issn.1672-6731.2014.06.002

  6. Effect of pantethine on ovarian tumor progression and choline metabolism

    Directory of Open Access Journals (Sweden)

    Marie-France Penet

    2016-11-01

    Full Text Available Epithelial ovarian cancer remains the leading cause of death from gynecologic malignancy among women in developed countries. New therapeutic strategies evaluated with relevant preclinical models are urgently needed to improve survival rates. Here we have assessed the effect of pantethine on tumor growth and metabolism using magnetic resonance imaging (MRI and high-resolution proton magnetic resonance spectroscopy (MRS in a model of ovarian cancer. To evaluate treatment strategies, it is important to use models that closely mimic tumor growth in humans. We therefore used an orthotopic model of ovarian cancer where a piece of tumor tissue, derived from an ovarian tumor xenograft, is engrafted directly onto the ovary of female mice, to maintain the tumor physiological environment. Treatment with pantethine, the precursor of vitamin B5 and active moiety of coenzyme A, was started when tumors were approximately 100 mm3, and consisted of a daily i.p. injection of 750 mg/kg in saline. Under these conditions, no side effects were observed. High-resolution 1H MRS was performed on treated and control tumor extracts. A dual-phase extraction method based on methanol/chloroform/water was used to obtain lipid and water-soluble fractions from the tumors. We also investigated effects on metastases and ascites formation. Pantethine treatment resulted in slower tumor progression, decreased levels of phosphocholine and phosphatidylcholine, and reduced metastases and ascites occurrence. In conclusion, pantethine represents a novel potential, well-tolerated, therapeutic tool in patients with ovarian cancer. Further in vivo preclinical studies are needed to confirm the beneficial role of pantethine and to better understand its mechanism of action.

  7. Perceived Exertion and Metabolic Cost during Progressive and ...

    African Journals Online (AJOL)

    The objective of the study was to ascertain whether selected physiological responses and the perception of effort varied during four different walk protocols where speed increased progressively 3, 4, 5, 6, and 7 km.hr-1 (progressive treadmill walk (PTW); and progressive land walk (PLW); or where the participant adjusted to ...

  8. The Community's research and development programme on decommissioning of nuclear installations (1989-1993). Annual progress report 1991

    International Nuclear Information System (INIS)

    1992-01-01

    This is the second annual progress report of the European Community's programme (1989-93) of research on decommissioning of nuclear installations. It shows the status of the programme on 31 December 1991. This second progress report summarizes the objectives, scope and work programme of the 76 research contracts concluded, as well as the progress of work achieved and the results obtained in 1991

  9. Kidney cancer progression linked to shifts in tumor metabolism

    Science.gov (United States)

    Investigators in The Cancer Genome Atlas Research Network have uncovered a connection between how tumor cells use energy from metabolic processes and the aggressiveness of the most common form of kidney cancer, clear cell renal cell carcinoma.

  10. Metabolic network as a progression biomarker of premanifest Huntington's disease

    NARCIS (Netherlands)

    Tang, Chris C.; Feigin, Andrew; Ma, Yilong; Habeck, Christian; Paulsen, Jane S.; Leenders, Klaus L.; Teune, Laura K.; van Oostrom, Joost C. H.; Guttman, Mark; Dhawan, Vijay; Eidelberg, David

    Background. The evaluation of effective disease-modifying therapies for neurodegenerative disorders relies on objective and accurate measures of progression in at-risk individuals. Here we used a computational approach to identify a functional brain network associated with the progression of

  11. Metabolic syndrome and other cardiovascular risk factors associated with the progression of IgA nephropathy

    OpenAIRE

    Kov?cs, Tibor; Vas, Tibor; Kovesdy, Csaba P.; K?s?i, Istv?n; S?gi, Bal?zs; Wittmann, Istv?n; Nagy, Judit

    2012-01-01

    Background The metabolic syndrome is associated with modest but independent and additive risk of new onset chronic kidney disease (CKD) in several studies. The purpose of our study was to determine whether metabolic syndrome and other cardiovascular risk factors (hyperuricaemia and smoking) are associated with the progression of IgA nephropathy (IgAN). Methods Two hundred and twenty three IgAN patients (107 with and 116 without metabolic syndrome) were examined. The primary renal end point wa...

  12. Studies in iodine metabolism: Progress report, July 1968-July 1969

    Energy Technology Data Exchange (ETDEWEB)

    Van Middlesworth, L.

    1987-01-01

    This document describes research on iodine metabolism conducted at the University of Tennessee, Memphis between July 1968 and July 1969. The author and his research team prepared autoradiographs of rat thyroids from individuals exposed to Iodine 125 in utero. Additional studies were conducted to determine the effect on hypothalamic lesions on iodide metabolism in rats; to evaluate an iodide-specific electrode for measuring iodide levels in blood or urine; and to study the amount of thyroxine absorption from the intestine. An analysis of bovine and sheep thyroids from eight locations provided additional information on global fallout levels. 21 figs., 2 tabs.

  13. Annual report on reactor safety research projects. Reporting period 2013. Progress report

    International Nuclear Information System (INIS)

    2013-01-01

    Within its competence for energy research the Federal Ministry of Economics and Technology (BMWi) sponsors research projects on the safety of nuclear power plants currently in operation. The objective of these projects is to provide fundamental knowledge, procedures and methods to contribute to realistic safety assessments of nuclear installations, to the further development of safety technology and to make use of the potential of innovative safety-related approaches. The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS)mbH, by order of the BMWi, continuously issues information on the status of such research projects by publishing semi-annual and annual progress reports within the series of GRSF- Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work. The progress reports are published by the Project Management Agency/Authority Support Division of GRS. The reports as of the year 2000 are available in the Internet-based information system on results and data of reactor safety research (http://www.grs-fbw.de). The compilation of the reports is classified according to the classification system ''Joint Safety Research Index (JSRI)''. The reports are arranged in sequence of their project numbers. It has to be pointed out that the authors of the reports are responsible for the contents of this compilation. The BMWi does not take any responsibility for the correctness, exactness and completeness of the information nor for the observance of private claims of third parties. (orig.)

  14. Health physics division annual progress report for period ending June 30, 1977

    Energy Technology Data Exchange (ETDEWEB)

    1978-07-01

    This annual progress report follows, as in the past, the organizational structure of the Health Physics Division. Each part is a report of work done by a section of the division: Assessment and Technology Section (Part I), headed by H.W. Dickson; Biological and Radiation Physics Section (Part II), H.A. Wright; Chemical Physics and Spectroscopy Section (Part III), W.R. Garrett; Emergency Technology Section (Part IV), C.V. Chester, Medical Physics and Internal Dosimetry Section (Part V), K.E. Cowser; and the Analytic Dosimetry and Education Group (Part VI), J.E. Turner.

  15. Research in theoretical elementary particle physics at the University of Florida: Task A. Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Field, R.D.; Ramond, P.M.; Sikivie, P.; Thorn, C.B.

    1994-12-01

    This is the Annual Progress Report of the theoretical particle theory group at the University of Florida under DOE Grant DE-FG05-86ER40272. At present our group consists of four Full Professors (Field, Ramond, Thorn, Sikivie), one Associate Professor (Woodard), and two Assistant Professors (Qiu, Kennedy). In addition, we have four postdoctoral research associates and seven graduate students. The research of our group covers a broad range of topics in theoretical high energy physics including both theory and phenomenology. Included in this report is a summary of the last several years, an outline of our current research program.

  16. Western Research Institute: Annual technical progress report, October 1987--September 1988

    Energy Technology Data Exchange (ETDEWEB)

    1988-12-01

    This report describes the technical progress made by the Western Research Institute of the University of Wyoming Research Institute of the University of Wyoming Research Corporation on work performed for the period October 1, 1987 through September 30, 1988. This research involves five resource areas: oil shale, tar sand, underground coal gasification, advanced process technology, and advanced fuels research. Under the terms of the cooperative agreement, an annual project plan has been approved by DOE. The work reported herein reflects the implementation of the research in the plan and follows the structure used therein. 49 refs., 32 figs., 87 tabs.

  17. Research in theoretical elementary particle physics at the University of Florida: Task A. Annual progress report

    International Nuclear Information System (INIS)

    Field, R.D.; Ramond, P.M.; Sikivie, P.; Thorn, C.B.

    1994-01-01

    This is the Annual Progress Report of the theoretical particle theory group at the University of Florida under DOE Grant DE-FG05-86ER40272. At present our group consists of four Full Professors (Field, Ramond, Thorn, Sikivie), one Associate Professor (Woodard), and two Assistant Professors (Qiu, Kennedy). In addition, we have four postdoctoral research associates and seven graduate students. The research of our group covers a broad range of topics in theoretical high energy physics including both theory and phenomenology. Included in this report is a summary of the last several years, an outline of our current research program

  18. Fuel performance improvement program. Quarterly/annual progress report, October 1977--September 1978

    International Nuclear Information System (INIS)

    Crouthamel, C.E.

    1978-10-01

    This quarterly/annual report reviews and summarizes the activities performed in support of the Fuel Performance Improvement Program (FPIP) during Fiscal Year 1978 with emphasis on those activities that transpired during the quarter ending September 30, 1978. Significant progress has been made in achieving the primary objectives of the program, i.e., to demonstrate commercially viable fuel concepts with improved fuel - cladding interaction (FCI) behavior. This includes out-of-reactor experiments to support the fuel concepts being evaluated, initiation of instrumented test rod experiments in the Halden Boiling Water Reactor (HBWR), and fabrication of the first series of demonstration rods for irradiation in the Big Rock Point Reactor

  19. FY2009 Annual Progress Report for Advanced Combustion Engine Research and Development

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2009-12-01

    Fiscal Year 2009 Annual Progress Report for the Advanced Combustion Engine Research and Development (R&D) subprogram. The Advanced Combustion Engine R&D subprogram supports the mission of the VTP program by removing the critical technical barriers to commercialization of advanced internal combustion engines (ICEs) for passenger and commercial vehicles that meet future Federal emissions regulations. Dramatically improving the efficiency of ICEs and enabling their introduction in conventional as well as hybrid electric vehicles is the most promising and cost-effective approach to increasing vehicle fuel economy over the next 30 years.

  20. Characterization of annual disease progression of multiple sclerosis patients: A population-based study

    DEFF Research Database (Denmark)

    Freilich, Jonatan; Manouchehrinia, Ali; Trusheim, Mark

    2017-01-01

    from each full EDSS with explanatory variables age, sex, age at onset, time in current EDSS, highest prior EDSS, MS course and treatment. All factors (except sex) investigated had statistically significant impacts on transitions from at least one EDSS. However, significance and size of the effect...... are dependent on the EDSS state of the patient. Greater age, longer time in a state, highest prior EDSS, having progressive MS and treatment had significant impacts, whereas age at onset had minor impact. Our study confirms that established factors associated with MS disease worsening in time to disease...... milestones also have impacts on annual progression. This approach adds granularity to what EDSS these factors have an influence....

  1. 2000 Annual Progress Report for Fuels for Advanced CIDI Engines and Fuel Cells

    Energy Technology Data Exchange (ETDEWEB)

    Chalk, S.

    2000-12-11

    The Department of Energy's Office of Transportation Technologies Fiscal Year (FY) 2000 Annual Progress Report for the Fuels for Advanced CIDI Engines and Fuel Cells Program highlights progress achieved during FY 2000 and comprises 22 summaries of industry and National Laboratory projects that were conducted. The report provides an overview of the exciting work being conducted to tackle the tough technical challenges associated with developing clean burning fuels that will enable meeting the performance goals of the Emission Control R and D for Advanced CIDI Engines and the Transportation Fuel Cell Power Systems Programs. The summaries cover the effects of CIDI engine emissions and fuel cell power system performance, the effects of lubricants on engine emissions, the effects of fuel and consumed lubricants on exhaust emission control devices and the health and safety, materials compatibility, and economics of advanced petroleum-based fuels.

  2. Obesity and Cancer Progression: Is There a Role of Fatty Acid Metabolism?

    Directory of Open Access Journals (Sweden)

    Seher Balaban

    2015-01-01

    Full Text Available Currently, there is renewed interest in elucidating the metabolic characteristics of cancer and how these characteristics may be exploited as therapeutic targets. Much attention has centered on glucose, glutamine and de novo lipogenesis, yet the metabolism of fatty acids that arise from extracellular, as well as intracellular, stores as triacylglycerol has received much less attention. This review focuses on the key pathways of fatty acid metabolism, including uptake, esterification, lipolysis, and mitochondrial oxidation, and how the regulators of these pathways are altered in cancer. Additionally, we discuss the potential link that fatty acid metabolism may serve between obesity and changes in cancer progression.

  3. Studies in iodine metabolism. Progress report, 1982-1983

    International Nuclear Information System (INIS)

    Van Middlesworth, L.

    1983-01-01

    Research progress is reported for the period 1982 to 1983 in the following areas: (1) monitoring of animal thyroids for 129 I, 125 I, 131 I, 226 Ra, and 228 Ra; and (2) neonatal hypo-l thyroidism in laboratory rats

  4. The UK fuel poverty strategy: 5th annual progress report 2007

    International Nuclear Information System (INIS)

    2007-12-01

    This fifth annual progress report details government progress in 2007 in tackling fuel poverty and movement towards targets. The United Kingdom were the first country in the world to recognise the issue of fuel poverty and to put in place measures to tackle the issue, including spending 20 billion pounds sterling on benefits and programmes since the year 2000. The report covers progress to date, schemes and initiatives to tackle fuel poverty, the energy market and looks ahead to the future. Progress and development of the schemes across the devolved nations are also considered. This report is the first to publish the Government's proposals for the Carbon Emissions Reduction Target (CERT) priority group, which were laid before Parliament on 5th December 2007. This report is the first to present the fuel poverty figures for 2005, and shows the effects of rising energy prices. The Government continues to take action to ensure that the energy market is working properly, and to encourage reform in the EU on energy market liberalisation - this should reduce pressure on prices. Those in fuel poverty have much to gain by switching supplier and this report outlines the action taken by Ofgem and Energywatch to encourage this

  5. The Community's research and development programme on decommissioning of nuclear installations. Second annual progress report (year 1986)

    International Nuclear Information System (INIS)

    1987-01-01

    This is the second annual progress report of the European Community's programme (1984-88) of research on the decommissioning of nuclear installations. It shows the status of the programme on 31 December 1986. This second progress report describes the objectives, scope and work programme of the 58 research contracts concluded, as well as the progress of work achieved and the results obtained in 1986

  6. Progress in understanding and engineering primary plant metabolism.

    Science.gov (United States)

    Stitt, Mark

    2013-04-01

    The maximum yield of crop plants depends on the efficiency of conversion of sunlight into biomass. This review summarises recent models that estimate energy conversion efficiency for successive steps in photosynthesis and metabolism. Photorespiration was identified as a major reason for energy loss during photosynthesis and strategies to modify or suppress photorespiration are presented. Energy loss during the conversion of photosynthate to biomass is also large but cannot be modelled as precisely due to incomplete knowledge about pathways and turnover and maintenance costs. Recent research on pathways involved in metabolite transport and interconversion in different organs, and recent insights into energy requirements linked to the production, maintenance and turnover of the apparatus for cellular growth and repair processes are discussed. Copyright © 2012 Elsevier Ltd. All rights reserved.

  7. Progress in genomics, metabolism and biotechnology of bifidobacteria.

    LENUS (Irish Health Repository)

    Cronin, Michelle

    2012-01-31

    Members of the genus Bifidobacterium were first described over a century ago and were quickly associated with a healthy intestinal tract due to their numerical dominance in breast-fed babies as compared to bottle-fed infants. Health benefits elicited by bifidobacteria to its host, as supported by clinical trials, have led to their wide application as probiotic components of health-promoting foods, especially in fermented dairy products. However, the relative paucity of genetic tools available for bifidobacteria has impeded development of a comprehensive molecular understanding of this genus. In this review we present a summary of current knowledge on bifidobacterial metabolism, classification, physiology and genetics and outline the currently available methods for genetically accessing and manipulating the genus.

  8. PET studies of brain energy metabolism in a model of subcortical dementia: progressive supranuclear Palsy

    International Nuclear Information System (INIS)

    Blin, J.; Baron, J.C.; Cambon, H.

    1988-01-01

    In 41 patients with clinically determined Progressive Supranuclear Palsy, a model of degenerative subcortical dementia, alterations in regional brain energy metabolism with respect to control subjects have been investigated using positron computed tomography and correlated to clinical and neuropsychological scores. A generalized significant reduction in brain metabolism was found, which predominated in the prefrontal cortex in accordance with, and statistically correlated to, the frontal neuropsychological score

  9. Magnetic fusion energy materials technology program annual progress report for period ending June 30, 1977

    International Nuclear Information System (INIS)

    Scott, J.L.

    1977-09-01

    The objectives of the Magnetic Fusion Energy (MFE) Materials Technology Program, which is described in this report, are to continue to solve the materials problems of the Fusion Energy Division of ORNL and to meet needs of the national MFE program, directed by the ERDA Division of Magnetic Fusion Energy (DMFE). This work is a continuation of the program described in previous annual progress reports. The principal areas of work include radiation effects, compatibility studies, materials studies related to the plasma-materials interaction, materials engineering, radiation behavior of superconducting magnet insulation, and mechanical properties of superconducting composites. The level of effort and schedules are consistent with Logic II of the DMFE Program Plan

  10. CTR plasma engineering studies. Annual progress report, 1 December 1985-30 November 1986

    International Nuclear Information System (INIS)

    Miley, G.H.

    1986-01-01

    The work described in this annual progress report covers a variety of topics ranging from alpha instabilities and current drive techniques to radiation heating of the first wall in a fusion device. Section II discusses work carried out on alpha instabilities, including comments on problems anticipated in the proposed compact ignition experiment and also recent studies of effects in tandem mirrors. Sections III and IV describe our recent efforts on RFP modelling. This includes a detailed study of oscillating field current drive (F-Θ) pumping and also parametric studies of ignition requirements. Section V presents a report of our application of control theory techniques to the stabilization of an elongated tokamak (ET) using feedback control of the plasma elongation. Section VI discusses our most recent study of the first-wall thermal response to plasma energy deposition while Section VII reviews our continuing study of techniques to radiation harden a wall detector for measuring alpha distributions in a burning plasma

  11. Task A: Research in theoretical elementary particle physics at the University of Florida; Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Field, R.D.; Ramond, P.M.; Sikivie, P.; Thorn, C.B.

    1993-11-01

    This is the Annual Progress Report of the theoretical particle theory group at the University of Florida under DoE Grant DE-FG05-86ER40272. At present our group consists of four Full Professors (Field, Ramond, Thorn, Sikivie) and three Assistant Professors (Qiu, Woodard, Kennedy). Dallas Kennedy recently joined our group increasing the Particle Theory faculty to seven. In addition, we have three postdoctoral research associates, an SSC fellow, and eight graduate students. The research of our group covers a broad range of topics in theoretical high energy physics with balance between theory and phenomenology. Included in this report is a summary of the last several years of operation of the group and an outline of our current research program.

  12. Annual Program Progress Report under DOE/PHRI Cooperative Agreement: (July 1, 2001-June 30, 2002)

    Energy Technology Data Exchange (ETDEWEB)

    Palafox, Neal A., MD, MPH

    2002-07-31

    OAK B188 DOE/PHRI Special Medical Care Program in the Republic of the Marshall Islands (RMI)Annual Program Progress Report. The DOE Marshall Islands Medical Program continued, in this it's 48th year, to provide medical surveillance for the exposed population from Rongelap and Utrik and the additional DOE patients. The program was inaugurated in 1954 by the Atomic Energy Commission following the exposure of Marshallese to fallout from a nuclear test (Castle Bravo) at Bikini Atoll. This year marks the fourth year in which the program has been carried out by PHRI under a cooperative agreement with DOE. The DOERHRI Special Medical Care Program, awarded the cooperative agreement on August 28, 1998, commenced its health care program on January 15, 1999, on Kwajalein and January 22, 1999, on Majuro. This report details the program for the July 1, 2001, through the June 30, 2002, period. The program provides year-round, on-site medical care to the DOE patient population residing in the Republic of the Marshall Islands (RMI) and annual examinations to those patients living in Hawaii and on the Continental U.S.

  13. Metabolic syndrome and other cardiovascular risk factors associated with the progression of IgA nephropathy.

    Science.gov (United States)

    Kovács, Tibor; Vas, Tibor; Kovesdy, Csaba P; Késõi, István; Sági, Balázs; Wittmann, István; Nagy, Judit

    2013-08-01

    The metabolic syndrome is associated with modest but independent and additive risk of new onset chronic kidney disease (CKD) in several studies. The purpose of our study was to determine whether metabolic syndrome and other cardiovascular risk factors (hyperuricaemia and smoking) are associated with the progression of IgA nephropathy (IgAN). Two hundred and twenty three IgAN patients (107 with and 116 without metabolic syndrome) were examined. The primary renal end point was doubling of serum creatinine; secondary end points were reaching eGFR of ≤ 60 ml/min/1,73m(2) or eGFR of ≤30 ml/min/1.73 m(2), and end-stage renal disease, ESRD (the composite of serum creatinine ≥500 μmol/l, initiation of dialysis treatment or transplantation). The association of metabolic syndrome with renal end points was examined using the Kaplan-Meier method and Cox models. Metabolic syndrome established at the diagnosis or during follow-up of IgAN patients was significantly associated with the primary renal end point (unadjusted hazard ratio of doubling of serum creatinine, 95% confidence interval: 1.96 (1.17-1.33, p = 0.011). The association remained significant after adjustment for confounders: 1.70 (1.02-3.83, p = 0.040). Results were similar for secondary end points except ESRD which was not associated with the presence of metabolic syndrome. Hyperuricaemia and smoking were independent risk factors of progression. Survival curves stratified on metabolic syndrome status showed significant differences for the end points (p = 0.017-0.001) except for ESRD. Early diagnosis and treatment of metabolic syndrome, hyperuricaemia and smoking may be an additional cost-effective strategy for preventing the progression of IgAN.

  14. Progressive alterations in lipid and glucose metabolism during short-term fasting in young adult men

    NARCIS (Netherlands)

    Klein, S.; Sakurai, Y.; Romijn, J. A.; Carroll, R. M.

    1993-01-01

    Stable isotope tracers and indirect calorimetry were used to evaluate the progressive alterations in lipid and glucose metabolism after 12, 18, 24, 30, 42, 54, and 72 h of fasting in six healthy male volunteers. The rates of appearance (Ra) of glycerol and palmitic acid in plasma doubled from 2.08

  15. Dissolved organic matter and lake metabolism. Technical progress report, 1 July 1975--30 June 1976

    Energy Technology Data Exchange (ETDEWEB)

    Wetzel, R. G.

    1976-01-01

    Progress is reported in the following areas of research: interactions of dissolved organic matter with inorganic nutrient cycling; regulation of the photosynthetic and decompositional metabolism of micro- and macroflora; regulatory mechanisms of growth and rates of carbon cycling; and fate of detrital dissolved and particulate organic matter. (HLW)

  16. Annual Report on Waste Generation and Waste Minimization Progress, 1991--1992

    International Nuclear Information System (INIS)

    1994-02-01

    This report is DOE's first annual report on waste generation and waste minimization progress. Data presented in this report were collected from all DOE sites which met minimum threshold criteria established for this report. The fifty-seven site submittals contained herein represent data from over 100 reporting sites within 25 states. Radioactive, hazardous and sanitary waste quantities and the efforts to minimize these wastes are highlighted within the fifty-seven site submittals. In general, sites have made progress in moving beyond the planning phase of their waste minimization programs. This is evident by the overall 28 percent increase in the total amount of materials recycled from 1991 to 1992, as well as individual site initiatives. During 1991 and 1992, DOE generated a total of 279,000 cubic meters of radioactive waste and 243,000 metric tons of non-radioactive waste. These waste amounts include significant portions of process wastewater required to be reported to regulatory agencies in the state of Texas and the state of Tennessee. Specifically, the Pantex Plant in Texas treats an industrial wastewater that is considered by the Texas Water Commission to be a hazardous waste. In 1992, State regulated wastewater from the Pantex Plant represented 3,620 metric tons, 10 percent of the total hazardous waste generated by DOE. Similarly, mixed low-level wastewater from the TSCA Incinerator Facility at the Oak Ridge K-25 Site in Tennessee represented 55 percent of the total radioactive waste generated by DOE in 1992

  17. Annual Report on Waste Generation and Waste Minimization Progress, 1991--1992

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-01

    This report is DOE`s first annual report on waste generation and waste minimization progress. Data presented in this report were collected from all DOE sites which met minimum threshold criteria established for this report. The fifty-seven site submittals contained herein represent data from over 100 reporting sites within 25 states. Radioactive, hazardous and sanitary waste quantities and the efforts to minimize these wastes are highlighted within the fifty-seven site submittals. In general, sites have made progress in moving beyond the planning phase of their waste minimization programs. This is evident by the overall 28 percent increase in the total amount of materials recycled from 1991 to 1992, as well as individual site initiatives. During 1991 and 1992, DOE generated a total of 279,000 cubic meters of radioactive waste and 243,000 metric tons of non-radioactive waste. These waste amounts include significant portions of process wastewater required to be reported to regulatory agencies in the state of Texas and the state of Tennessee. Specifically, the Pantex Plant in Texas treats an industrial wastewater that is considered by the Texas Water Commission to be a hazardous waste. In 1992, State regulated wastewater from the Pantex Plant represented 3,620 metric tons, 10 percent of the total hazardous waste generated by DOE. Similarly, mixed low-level wastewater from the TSCA Incinerator Facility at the Oak Ridge K-25 Site in Tennessee represented 55 percent of the total radioactive waste generated by DOE in 1992.

  18. Assessment of Food Chain Pathway Parameters in Biosphere Models: Annual Progress Report for Fiscal Year 2004

    Energy Technology Data Exchange (ETDEWEB)

    Napier, Bruce A.; Krupka, Kenneth M.; Fellows, Robert J.; Cataldo, Dominic A.; Valenta, Michelle M.; Gilmore, Tyler J.

    2004-12-02

    This Annual Progress Report describes the work performed and summarizes some of the key observations to date on the U.S. Nuclear Regulatory Commission’s project Assessment of Food Chain Pathway Parameters in Biosphere Models, which was established to assess and evaluate a number of key parameters used in the food-chain models used in performance assessments of radioactive waste disposal facilities. Section 2 of this report describes activities undertaken to collect samples of soils from three regions of the United States, the Southeast, Northwest, and Southwest, and perform analyses to characterize their physical and chemical properties. Section 3 summarizes information gathered regarding agricultural practices and common and unusual crops grown in each of these three areas. Section 4 describes progress in studying radionuclide uptake in several representative crops from the three soil types in controlled laboratory conditions. Section 5 describes a range of international coordination activities undertaken by Project staff in order to support the underlying data needs of the Project. Section 6 provides a very brief summary of the status of the GENII Version 2 computer program, which is a “client” of the types of data being generated by the Project, and for which the Project will be providing training to the US NRC staff in the coming Fiscal Year. Several appendices provide additional supporting information.

  19. Comparative evaluation of the influence of diabetic retinopathy progression factors on indices of lipid metabolism in metabolic syndrome

    Directory of Open Access Journals (Sweden)

    L.Yu. Pуlуpenko

    2017-11-01

    Full Text Available Background. The search and study of new risk factors for the development and progression of diabetic retinopathy (DRP and their modifying influence on the components of metabolic syndrome in type 2 diabetes mellitus (T2DM remain relevant. The purpose was to conduct a comparative evaluation of the impact of certain DRP development factors on indices of lipid metabolism in metabolic syndrome. Materials and methods. The research was carried out in 64 patients (95 eyes with T2DM, metabolic syndrome and DRP (males and females, average age 61.55 ± 2.37 years, average duration of diabetes 11.23 ± 2.11 years, average level of HbA1c 9.89 ± 0.78 %, average body mass index 34.55 ± 3.75 kg/m2, who were divided into 3 groups depending on the stage of DRP. Results. Results had showed that the following factors have modifying influence on the level of total cholesterol in the blood of patients with T2DM and DRP: age of patients (under 60 years, duration of diabetes (less than 10 years, decompensation of carbohydrates metabolism — for the 3rd stage of DRP, features of therapy for T2DM (oral hypoglycemic drugs — for the 2nd stage of DRP; on the level of low-density lipoprotein cholesterol: younger age of patients, decompensation of diabetes — for the 3rd stage of DRP, features of hypoglycemic therapy (insulin therapy, shorter duration of diabetes — for the 2nd stage of DRP; on the level of triglycerides: age of patients (under 60 years, duration of diabetes (less than 10 years and insulin therapy — for the 1st and 3rd stages of DRP. Conclusions. It is concluded that features of hypoglycemic therapy can be a new modifying factor for the risk of DRP progression.

  20. Influence of the definition of "metabolically healthy obesity" on the progression of coronary artery calcification.

    Directory of Open Access Journals (Sweden)

    Ji Won Yoon

    Full Text Available Debates whether metabolically healthy obesity (MHO increases the cardiovascular risk might be due to the metabolic instability of MHO or the absence of a perfect definition of MHO. Therefore, we aimed to investigate the influence of the MHO phenotype on the coronary artery calcium score (CACS progression according to definition of MHO.We analyzed a retrospective cohort with a CACS of 0 at baseline and available serial CACS measurements taken ≥ 12 months apart (n = 1,218. Obesity was defined as BMI ≥ 25 kg/m2, and MHO was defined as obesity accompanied by ≤ 1 (MHO class I or 0 (MHO class II components of metabolic syndrome (MetS.During a median follow-up of 45 months, 32.2% of MHO class I and 10.2% of MHO class II subjects developed MetS. Compared to non-obese/metabolically healthy subjects (reference group, hazard ratios (HR for development of MetS were 2.174 (95% confidence interval [CI]: 1.513-3.124 and 1.166 (95% CI: 0.434-3.129 for MHO class I and II subjects, respectively. The MHO class I subjects showed a significantly increased risk of CACS progression as compared to the reference group (HR: 1.653; 95% CI: 1.144-2.390, whereas MHO class II subjects did not (HR: 1.195; 95% CI: 0.514-2.778. Among subjects with MHO class I, no significant CACS progression was observed in the subjects who maintained metabolic health during follow-up (HR: 1.448; 95% CI: 0.921-2.278.The risks of metabolic deterioration and CACS progression were significant in subjects with MHO class I, but not in those with MHO class II.

  1. Materials project of the Energy Conversion and Utilization Technologies (ECUT) program for Fiscal Year 1983: Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Morris, L.E.; Jordan, A.; Carpenter, J.A. Jr.

    1987-02-01

    This is the annual technical progress report for fiscal year 1983 of the Materials Project of the US Department of Energy (DOE) Energy Conversion and Utilization Technologies (ECUT) Program. In fiscal year 1983, the ECUT Materials Project conducted research in four technical areas, or ''work elements,'' entitled High Temperature Materials, Lightweight Materials, Materials by Design, and New Assessments and Initiatives. The progress of the various tasks of the work elements is discussed in this report.

  2. The Role of Mitochondria in Cancer Induction, Progression and Changes in Metabolism.

    Science.gov (United States)

    Rogalinska, Malgorzata

    2016-01-01

    Mitochondria play important roles as energetic centers. Mutations in mitochondrial DNA (mtDNA) were found in several diseases, including cancers. Studies on cytoplasmic hybrids (cybrids) confirm that directed mutation introduced into mtDNA could be a reason for cancer induction. Mitochondria could also be a factor linking cancer transformation and progression. The importance of mitochondria in cancer also confirms their involvement in the resistance to treatment. Resistance to treatment of cancer cells can frequently be a reason for glycolysis acceleration. It could be explained by cancer cells' high proliferation index and high energy request. The involvement of mitochondria in metabolic disturbances of several metabolic diseases, including cancers, was reported. These data confirm that cancer induction, as well as cancer progression, could have metabolic roots. The aberrant products observed in prostate cells involved in the Krebs cycle could promote cancer progression. These multiple relationships between alterations on a genetic level translated into disturbances in cellular metabolism and their potential relation with epigenetic control of gene expression make cancerogenesis more complicated and prognoses' success in studies on cancer etiology more distant in time.

  3. Environmental Sciences Division annual progress report for period ending September 30, 1982. Environmental Sciences Division Publication No. 2090

    International Nuclear Information System (INIS)

    1983-04-01

    Separate abstracts were prepared for 12 of the 14 sections of the Environmental Sciences Division annual progress report. The other 2 sections deal with educational activities. The programs discussed deal with advanced fuel energy, toxic substances, environmental impacts of various energy technologies, biomass, low-level radioactive waste management, the global carbon cycle, and aquatic and terrestrial ecology

  4. Twenty-ninth annual progress report of the Pennsylvania State University Breazeale Nuclear Reactor, July 1, 1983-June 30, 1984

    International Nuclear Information System (INIS)

    Levine, S.H.; Totenbier, R.E.

    1984-07-01

    The twenty-ninth annual progress report of the operation of the Pennsylvania State University Breazeale Reactor is submitted in accordance with the requirements of Contract DE-AC02-76ER03409 with the United States Department of Energy. This report also provides the University administration with a summary of the operation of the facility for the past year

  5. Environmental Sciences Division annual progress report for period ending September 30, 1982. Environmental Sciences Division Publication No. 2090. [Lead abstract

    Energy Technology Data Exchange (ETDEWEB)

    1983-04-01

    Separate abstracts were prepared for 12 of the 14 sections of the Environmental Sciences Division annual progress report. The other 2 sections deal with educational activities. The programs discussed deal with advanced fuel energy, toxic substances, environmental impacts of various energy technologies, biomass, low-level radioactive waste management, the global carbon cycle, and aquatic and terrestrial ecology. (KRM)

  6. Semi-annual progress report for the period ending December 31, 1958

    Energy Technology Data Exchange (ETDEWEB)

    None

    1958-01-01

    Studies were continued on radiation-induced reactions of nitrophenols and ferriprotoporphyrins. No changes in serum glycoproteins or seromucoids were detected in embryo chickens and young chicks as a result of irradiation. Progress is reported in studies on: the radiosensitivity of bacteriophages; the influence of x irradiation on thiamine transport in rat intestine; the histologic changes in bone, marrow, blood, and other body tissues due to localized ..beta.. irradiation; the effects of irradiation on nervous responses in cats; studies of fatty acid metabolism in rats; electrophoretic studies of abnormal plasma proteins; the specificity of thyroxin inhibition of acyl phosphatase; the pharmacological properties of Mellaril; the local toxicity of organic moderators for intact and abraded skin; the effects of oral quinoxaline on radiation mortality in mice; the development of leukemia and other neoplasms in mice receiving cell-free tissue extracts from a high-leukemia strain; the development of liver function tests using iodine-131-Rose Bengal; development of techniques and equipment of renograms using iodine-131 Miokon; the development of sensitive tests for the diagnosis of liver and kidney diseases; tracer studies of bone metabolism; the development of radiation detection instruments and chemical dosimeters; an underwater spark pulser, an improved illuminating system for the electron microscope; and techniques for electron microscopic studies of tissues and the spectrographic analysis of plant ash; studies on the fate and persistence of strontium-90 and cesium-137 in various locations and biological materials collected in the vicinity of the Nevada Test Site; and aerial surveying for evaluation of fall-out patterns.

  7. Fusion Energy Division annual progress report, period ending December 31, 1989

    Energy Technology Data Exchange (ETDEWEB)

    Sheffield, J.; Baker, C.C.; Saltmarsh, M.J.

    1991-07-01

    The Fusion Program of Oak Ridge National Laboratory (ORNL) carries out research in most areas of magnetic confinement fusion. The program is directed toward the development of fusion as an energy source and is a strong and vital component of both the US fusion program and the international fusion community. Issued as the annual progress report of the ORNL Fusion Energy Division, this report also contains information from components of the Fusion Program that are carried out by other ORNL organizations (about 15% of the program effort). The areas addressed by the Fusion Program and discussed in this report include the following: Experimental and theoretical research on magnetic confinement concepts, engineering and physics of existing and planned devices, including remote handling, development and testing of diagnostic tools and techniques in support of experiments, assembly and distribution to the fusion community of databases on atomic physics and radiation effects, development and testing of technologies for heating and fueling fusion plasmas, development and testing of superconducting magnets for containing fusion plasmas, development and testing of materials for fusion devices, and exploration of opportunities to apply the unique skills, technology, and techniques developed in the course of this work to other areas. Highlights from program activities are included in this report.

  8. Energy Division annual progress report for period ending September 30, 1988

    International Nuclear Information System (INIS)

    1989-06-01

    The goals and accomplishments of the Energy Division of Oak Ridge National Laboratory are described in this annual progress report for Fiscal Year (FY) 1988. The Energy Division is a multidisciplinary research organization committed to (1) increasing the knowledge and understanding of the way society makes choices in energy use and energy-using technologies, (2) improving society's understanding of the environmental implications of changes in energy technology, and (3) improving and developing new energy-efficient technologies. The Energy Division's programmatic activities focus on four major areas: (1) analysis and assessment, (2) transportation and decision systems research, (3) technology research and development for improving the efficiency of energy and end-use technologies, and (4) electric power systems. The Division's total expenditures in FY 1988 were $44.3 million. The work is supported by the US Department of Energy, US Department of Defense, many other federal agencies, and some private organizations. Disciplines of the 139 staff members include engineering, social sciences, physical and life sciences, and mathematics and statistics

  9. Energy Division annual progress report for period ending September 30, 1988: Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    1989-06-01

    The goals and accomplishments of the Energy Division of Oak Ridge National Laboratory are described in this annual progress report for Fiscal Year (FY) 1988. The Energy Division is a multidisciplinary research organization committed to (1) increasing the knowledge and understanding of the way society makes choices in energy use and energy-using technologies, (2) improving society's understanding of the environmental implications of changes in energy technology, and (3) improving and developing new energy-efficient technologies. The Energy Division's programmatic activities focus on four major areas: (1) analysis and assessment, (2) transportation and decision systems research, (3) technology research and development for improving the efficiency of energy and end-use technologies, and (4) electric power systems. The Division's total expenditures in FY 1988 were $44.3 million. The work is supported by the US Department of Energy, US Department of Defense, many other federal agencies, and some private organizations. Disciplines of the 139 staff members include engineering, social sciences, physical and life sciences, and mathematics and statistics.

  10. Fusion Energy Division annual progress report, period ending December 31, 1989

    International Nuclear Information System (INIS)

    Sheffield, J.; Baker, C.C.; Saltmarsh, M.J.

    1991-07-01

    The Fusion Program of Oak Ridge National Laboratory (ORNL) carries out research in most areas of magnetic confinement fusion. The program is directed toward the development of fusion as an energy source and is a strong and vital component of both the US fusion program and the international fusion community. Issued as the annual progress report of the ORNL Fusion Energy Division, this report also contains information from components of the Fusion Program that are carried out by other ORNL organizations (about 15% of the program effort). The areas addressed by the Fusion Program and discussed in this report include the following: Experimental and theoretical research on magnetic confinement concepts, engineering and physics of existing and planned devices, including remote handling, development and testing of diagnostic tools and techniques in support of experiments, assembly and distribution to the fusion community of databases on atomic physics and radiation effects, development and testing of technologies for heating and fueling fusion plasmas, development and testing of superconducting magnets for containing fusion plasmas, development and testing of materials for fusion devices, and exploration of opportunities to apply the unique skills, technology, and techniques developed in the course of this work to other areas. Highlights from program activities are included in this report

  11. Energy Division annual progress report for period ending September 30, 1990

    Energy Technology Data Exchange (ETDEWEB)

    Selden, R.H. (ed.)

    1991-06-01

    The Energy Division is one of 17 research divisions at Oak Ridge National Laboratory. The goals and accomplishments of the Energy Division are described in this annual progress report for FY 1990. The Energy Division is a multidisciplinary research organization committed to (1) increasing the knowledge and understanding of how societies make choices in energy use; (2) improving society's understanding of the environmental, social, and economic implications of technological change; (3) developing and transferring energy efficient technologies; and (4) developing improved transportation planning and policy. Disciplines of the 129 staff members include engineering, social sciences, physical and life sciences, and mathematics and statistics. The Energy Division's programmatic activities focus on three major areas: (1) analysis and assessment, (2) energy conservation technologies, and (3) military transportation systems. Analysis and assessment activities cover energy and resource analysis, the preparation of environmental assessments and impact statements, research on waste management, analysis of emergency preparedness for natural and technological disasters, analysis of the energy and environmental needs of developing countries, technology transfer, and analysis of civilian transportation. Energy conservation technologies include building equipment (thermally activated heat pumps, chemical heat pumps, refrigeration systems, novel cycles), building enveloped (walls, foundations, roofs, attics, and materials), retrofits for existing buildings, and electric power systems. Military transportation systems concentrate on research for sponsors within the US military on improving the efficiency of military deployment, scheduling, and transportation coordination. 48 refs., 34 figs., 7 tabs.

  12. Energy Division annual progress report for period ending September 30, 1991

    Energy Technology Data Exchange (ETDEWEB)

    Stone, J.N. [ed.

    1992-04-01

    The Energy Division is one of 17 research divisions at Oak Ridge Laboratory. Its goals and accomplishments are described in this annual progress report for FY 1991. The division`s total expenditures in FY 1991 were $39.1 million. The work is supported by the US Department of Energy, US Department of Defense, many other federal agencies, and some private organizations. Disciplines of the 124 technical staff members include engineering, social sciences, physical and life sciences, and mathematics and statistics. The Energy Division`s programmatic activities focus on three major areas: (1) analysis and assessment, (2) energy conservation technologies, and (3) military transportation systems. Analysis and assessment activities cover energy and resource analysis, the preparation of environmental assessments and impact statements, research on waste management, analysis of emergency preparedness for natural and technological disasters, analysis of the energy and environmental needs of developing countries, technology transfer, and analysis of civilian transportation. Energy conservation technologies include electric power systems, building equipment (thermally activated heat pumps, advanced refrigeration systems, novel cycles), building envelopes (walls, foundations, roofs, attics, and materials), and technical issues for improving energy efficiency in existing buildings. Military transportation systems concentrate on research for sponsors within the US military on improving the efficiency of military deployment, scheduling, and transportation coordination.

  13. Energy Division annual progress report for period ending September 30, 1991

    Energy Technology Data Exchange (ETDEWEB)

    Stone, J.N. (ed.)

    1992-04-01

    The Energy Division is one of 17 research divisions at Oak Ridge Laboratory. Its goals and accomplishments are described in this annual progress report for FY 1991. The division's total expenditures in FY 1991 were $39.1 million. The work is supported by the US Department of Energy, US Department of Defense, many other federal agencies, and some private organizations. Disciplines of the 124 technical staff members include engineering, social sciences, physical and life sciences, and mathematics and statistics. The Energy Division's programmatic activities focus on three major areas: (1) analysis and assessment, (2) energy conservation technologies, and (3) military transportation systems. Analysis and assessment activities cover energy and resource analysis, the preparation of environmental assessments and impact statements, research on waste management, analysis of emergency preparedness for natural and technological disasters, analysis of the energy and environmental needs of developing countries, technology transfer, and analysis of civilian transportation. Energy conservation technologies include electric power systems, building equipment (thermally activated heat pumps, advanced refrigeration systems, novel cycles), building envelopes (walls, foundations, roofs, attics, and materials), and technical issues for improving energy efficiency in existing buildings. Military transportation systems concentrate on research for sponsors within the US military on improving the efficiency of military deployment, scheduling, and transportation coordination.

  14. MHD Coal-Fired Flow Facility. Quarterly/annual technical progress report, October-December 1979

    Energy Technology Data Exchange (ETDEWEB)

    Dicks, J. B.; Chapman, J. N.; Crawford, L. W.

    1980-02-01

    In this Fourth Quarterly/Annual Report submitted under DOE contracts EX-76-C-01-1760 and DE-AC02-79ET10815, the University of Tennessee Space Institute (UTSI) reports on significant activity, task status, planned research, testing, and development, and conclusions for the Magnetohydrodynamics (MHD) Coal-Fired Flow Facility (CFFF) and the Research and Development Laboratory. Work on the CFFF progressed with only minor problems. Total construction activity for all site work presently awarded is nearly 98% complete. Water analysis shows that Woods Reservoir baseline conditions are within EPA or Tennessee drinking water standards. For the primary combustor, the vitiation heater and primary combustor fabrication drawings were completed and the nozzle design was completed. The drum module for the radiant slagging furnace was awarded. On the MHD Power Generator, development continued in several areas of advanced analysis including development of time-dependent models for use with the one-dimensional code. For seed regeneration, the tentative determination is that the Tomlinson Tampella is the most economically viable method. With regard to capped electrode erosion, investigations have shown that the major degradation of the cladding still present is at the leading edge of the capped anode. To alleviate this, plans are to hot work the noble metal in the bending operation. In resolving another problem, a system employing the modified line-reversal method has been assembled and successfully tested to measure absolute plasma temperatures.

  15. Fusion Energy Division: Annual progress report, period ending December 31, 1987

    Energy Technology Data Exchange (ETDEWEB)

    Morgan, O.B. Jr.; Berry, L.A.; Sheffield, J.

    1988-11-01

    The Fusion Program of Oak Ridge National Laboratory (ORNL), a major part of the national fusion program, carries out research in nearly all areas of magnetic fusion. Collaboration among staff from ORNL, Martin Marietta Energy Systems, Inc., private industry, the academic community, and other fusion laboratories, in the United States and abroad, is directed toward the development of fusion as an energy source. This report documents the program's achievements during 1987. Issued as the annual progress report of the ORNL Fusion Energy Division, it also contains information from components of the Fusion Program that are external to the division (about 15% of the program effort). The areas addressed by the Fusion Program include the following: experimental and theoretical research on magnetic confinement concepts, engineering and physics of existing and planned devices, development and testing of diagnostic tools and techniques in support of experiments, assembly and distribution to the fusion community of databases on atomic physics and radiation effects, development and testing of technologies for heating and fueling fusion plasmas, development and testing of superconducting magnets for containing fusion plasmas, and development and testing of materials for fusion devices. Highlights from program activities are included in this report. 126 figs., 15 tabs.

  16. Fusion Energy Division: Annual progress report, period ending December 31, 1987

    International Nuclear Information System (INIS)

    Morgan, O.B. Jr.; Berry, L.A.; Sheffield, J.

    1988-11-01

    The Fusion Program of Oak Ridge National Laboratory (ORNL), a major part of the national fusion program, carries out research in nearly all areas of magnetic fusion. Collaboration among staff from ORNL, Martin Marietta Energy Systems, Inc., private industry, the academic community, and other fusion laboratories, in the United States and abroad, is directed toward the development of fusion as an energy source. This report documents the program's achievements during 1987. Issued as the annual progress report of the ORNL Fusion Energy Division, it also contains information from components of the Fusion Program that are external to the division (about 15% of the program effort). The areas addressed by the Fusion Program include the following: experimental and theoretical research on magnetic confinement concepts, engineering and physics of existing and planned devices, development and testing of diagnostic tools and techniques in support of experiments, assembly and distribution to the fusion community of databases on atomic physics and radiation effects, development and testing of technologies for heating and fueling fusion plasmas, development and testing of superconducting magnets for containing fusion plasmas, and development and testing of materials for fusion devices. Highlights from program activities are included in this report. 126 figs., 15 tabs

  17. Repeat cross-sectional data on the progression of the metabolic syndrome in Ossabaw miniature swine

    Directory of Open Access Journals (Sweden)

    Mikaela L. McKenney-Drake

    2016-06-01

    Full Text Available Ossabaw miniature swine were fed an excess calorie, atherogenic diet for 6, 9, or 12 months. Increased body weight, hypertension, and increased plasma cholesterol and triglycerides are described in Table 1. For more detailed interpretations and conclusions about the data, see our associated research study, “Biphasic alterations in coronary smooth muscle Ca2+ regulation during coronary artery disease progression in metabolic syndrome” McKenney-Drake, et al. (2016 [1].

  18. Metabolic cooperation between cancer and non-cancerous stromal cells is pivotal in cancer progression.

    Science.gov (United States)

    Lopes-Coelho, Filipa; Gouveia-Fernandes, Sofia; Serpa, Jacinta

    2018-02-01

    The way cancer cells adapt to microenvironment is crucial for the success of carcinogenesis, and metabolic fitness is essential for a cancer cell to survive and proliferate in a certain organ/tissue. The metabolic remodeling in a tumor niche is endured not only by cancer cells but also by non-cancerous cells that share the same microenvironment. For this reason, tumor cells and stromal cells constitute a complex network of signal and organic compound transfer that supports cellular viability and proliferation. The intensive dual-address cooperation of all components of a tumor sustains disease progression and metastasis. Herein, we will detail the role of cancer-associated fibroblasts, cancer-associated adipocytes, and inflammatory cells, mainly monocytes/macrophages (tumor-associated macrophages), in the remodeling and metabolic adaptation of tumors.

  19. Dissolved organic matter and lake metabolism. Technical progress report, 1 July 1976--30 June 1977

    Energy Technology Data Exchange (ETDEWEB)

    Wetzel, R.G.

    1977-01-01

    Progress is reported on investigations on the qualitative and quantitative cycling of particulate and dissolved organic matter within lakes and their drainage basins. Interactions of dissolved organic matter with inorganic nutrient cycling and regulation of the photosynthetic and decompositional metabolism of micro- and macroflora remain the focal point of these studies. Major efforts were directed towards the sources fates, pathways, and interactions of dissolved organic matter in inorganic chemical cycling; allochthonous sources, metabolism en route, and inputs to the lake systems of increasing stages of eutrophication; and the relationships of these compounds to the nutrient physiology and metabolism of phytoplankton, sessile algae, macrophytes, and bacterial populations. Results of studies carried out in a freshwater lake in Michigan (Lawrence Lake) are reported. 165 references.

  20. Determining significant endpoints for ecological risk analyses. 1997 annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Hinton, T.G.; Congdon, J.; Rowe, C.; Scott, D. [Univ. of Georgia, Aiken, SC (US). Savannah River Ecology Lab.; Bedford, J.; Whicker, F.W. [Colorado State Univ., Fort Collins, CO (US)

    1997-11-01

    'This report summarizes the first year''s progress of research funded under the Department of Energy''s Environmental Management Science Program. The research was initiated to better determine ecological risks from toxic and radioactive contaminants. More precisely, the research is designed to determine the relevancy of sublethal cellular damage to the performance of individuals and to identify characteristics of non-human populations exposed to chronic, low-level radiation, as is typically found on many DOE sites. The authors propose to establish a protocol to assess risks to non-human species at higher levels of biological organization by relating molecular damage to more relevant responses that reflect population health. They think that they can achieve this by coupling changes in metabolic rates and energy allocation patterns to meaningful population response variables, and by using novel biological dosimeters in controlled, manipulative dose/effects experiments. They believe that a scientifically defensible endpoint for measuring ecological risks can only be determined once its understood the extent to which molecular damage from contaminant exposure is detrimental at the individual and population levels of biological organization.'

  1. 3-D spectral IP imaging: Non-invasive characterization of contaminant plumes. 1998 annual progress report

    International Nuclear Information System (INIS)

    Lesmes, D.; Morgan, F.D.; Rodi, W.

    1998-01-01

    'The overall objective of this project is to develop the scientific basis for characterizing contaminant plumes in the earth''s subsurface using field measurements of induced polarization (IP) effects. Three specific objectives towards this end are: (1) understanding IP at the laboratory level through measurements of complex resistivity as a function of frequency in rock and soil samples with varying pore geometries, pore fluid conductivities and saturations, and contaminant chemistries and concentrations; (2) developing effective data acquisition techniques for measuring the critical IP responses (time domain or frequency domain) in the field; (3) developing modeling and inversion algorithms that permit the interpretation of field IP data in terms of subsurface geology and contaminant plume properties. The authors laboratory experiments to date are described in Appendices A and B, which consist of two papers submitted to the annual SAGEEP conference (Frye et al., 1998; Sturrock et al., 1998). The experiments involved measurements of complex resistivity vs. frequency on a suite of brine saturated sandstone samples. In one set of experiments, the fluid chemistry (pH, ionic strength, and cation type) was varied. In a second set of experiments, the microgeometry of the rock matrix was varied. The experiments showed that spectral IP responses are sensitive to subtle variations in both the solution chemistry and rock microgeometry. The results demonstrate that spectral IP responses have the potential of being sensitive indicators of in-situ chemistry and microgeometry, the latter of which may be related to the hydraulic properties. Data Acquisition The authors have been looking in some detail at the effects of electromagnetic coupling and how to practically deal with it. In this area, the results to date are summarized in Vandiver (1998). The progress in the development of modeling and inversion algorithms for IP is described in Appendix C, a paper submitted to the

  2. Canada's climate change voluntary challenge and registry program : 6. annual progress report

    International Nuclear Information System (INIS)

    2000-10-01

    A Canadian integrated energy company, Suncor Energy Inc. comprises a corporate group, three operating business units, and two emerging businesses. This annual Progress Report for Canada's Climate Change Voluntary Challenge and Registry (VCR) Program represents the sixth for this company. Suncor is committed to sustainable development. Some initiatives undertaken in 1999 by Suncor included: Oil Sands Project Millennium, which will more than double the actual production of crude oil and fuel products by 2002. Suncor is divesting of conventional oil properties in order to concentrate on exploration and production of natural gas. Alternative and renewable energy will see an investment of 100 million over the next five years. The money will be allocated to research and development, the production of fuels from biomass, and conversion of municipal solid waste to energy through the recovery of methane from landfills. Since 1990, the emissions of carbon dioxide have been reduced to 14 per cent below 1990 levels, and reductions of 622, 000 tonnes of greenhouse gases. A comprehensive tracking, reporting, and management system for greenhouse gases was implemented. Ongoing improvements in quality and comprehensiveness have validated the methodology used to monitor emissions inventories and sources. Initiatives in internal and external awareness of greenhouse gases education were implemented, such as speaking engagements at climate change activities, the retrofit of schools with advanced energy-efficient technology, education programs, employee suggestion programs, etc. Collaboration with external partners on research and development projects represents a major building block in this approach. Some of the research and development projects involve the development of advanced carbon dioxide capture and geologic sequestration technologies, work on the production of alternative and renewable energy from Canadian municipal landfills, and the study of a new process to extract heavy

  3. Energy Division annual progress report for period ending September 30, 1992

    Energy Technology Data Exchange (ETDEWEB)

    Counce, D.M.; Wolff, P.P. [eds.

    1993-04-01

    Energy Division`s mission is to provide innovative solutions to energy and related Issues of national and global importance through interdisciplinary research and development. Its goals and accomplishments are described in this annual progress report for FY 1992. Energy Division`s total expenditures in FY 1992 were $42.8 million. The work is supported by the US Department of Energy, the US Department of Defense, many other federal agencies, and some private organizations. Disciplines of the 116.5 technical staff members include engineering, social sciences, physical and life sciences, and mathematics and statistics. The division`s programmatic activities cover three main areas: (1) analysis and assessment, (2) energy conservation technologies, and (3) military transportation systems. Analysis and assessment activities involve energy and resource analysis, preparation of environmental assessments and impact statements, research on waste management, technology transfer, analysis of energy and environmental needs in developing countries, and civilian transportation analysis. Energy conservation technologies focus on electric power systems, building envelopes (walls, foundations, roofs, attics, and materials), and methods to improve energy efficiency in existing buildings. Military transportation systems conduct research for sponsors within the US military to improve the efficiency of military deployment, scheduling, and transportation coordination. Much of Energy Division`s research is valuable to other organizations as well as to sponsors. This information is disseminated by the staff`s involvement in professional and trade organizations and workshops; joint research with universities and private-sector firms; collaboration with state and local governments; presentation of work at conferences; and publication of research results in journals, reports, and conference proceedings.

  4. Energy Division annual progress report for period ending September 30, 1993

    International Nuclear Information System (INIS)

    Wolff, P.P.

    1994-07-01

    One of 17 research divisions at Oak Ridge National Laboratory, Energy Division's mission is to provide innovative solutions to energy and related issues of national and global importance through interdisciplinary research and development. Its goals and accomplishments are described in this annual progress report for FY1993. Energy Division is committed to (1) understanding the mechanisms by which societies make choices in energy use; (2) improving society's understanding of the environmental, social, and economic implications of technological change; (3) developing and transferring energy-efficient technologies; (4) improving transportation policy and planning; (5) enhancing basic knowledge in the social sciences as related to energy and associated issues. Energy Division's expenditures in FY1993 totaled $42 million. The work was supported by the US DOE, DOD, many other federal agencies, and some private organizations. Disciplines of the 126.5 technical staff members include engineering, social sciences, physical and life sciences, and computer sciences and data systems. The division's programmatic activities cover three main areas: (1) analysis and assessment, (2) energy use and delivery technologies, and (3) transportation systems. Analysis and assessment activities involve energy and resource analysis, preparation of environmental assessments and impact statements, research on emergency preparedness, transportation analysis, and analysis of energy and environmental needs in developing countries. Energy use and delivery technologies focus on electric power systems, building equipment, building envelopes (walls, foundations, roofs, attics, and materials), and methods to improve energy efficiency in existing buildings. Transportation systems research is conducted both to improve the quality of civilian transportation and for sponsors within the US military to improve the efficiency of deployment, scheduling, and transportation coordination

  5. Energy Division annual progress report for period ending September 30, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Wolff, P.P. [ed.

    1994-07-01

    One of 17 research divisions at Oak Ridge National Laboratory, Energy Division`s mission is to provide innovative solutions to energy and related issues of national and global importance through interdisciplinary research and development. Its goals and accomplishments are described in this annual progress report for FY1993. Energy Division is committed to (1) understanding the mechanisms by which societies make choices in energy use; (2) improving society`s understanding of the environmental, social, and economic implications of technological change; (3) developing and transferring energy-efficient technologies; (4) improving transportation policy and planning; (5) enhancing basic knowledge in the social sciences as related to energy and associated issues. Energy Division`s expenditures in FY1993 totaled $42 million. The work was supported by the US DOE, DOD, many other federal agencies, and some private organizations. Disciplines of the 126.5 technical staff members include engineering, social sciences, physical and life sciences, and computer sciences and data systems. The division`s programmatic activities cover three main areas: (1) analysis and assessment, (2) energy use and delivery technologies, and (3) transportation systems. Analysis and assessment activities involve energy and resource analysis, preparation of environmental assessments and impact statements, research on emergency preparedness, transportation analysis, and analysis of energy and environmental needs in developing countries. Energy use and delivery technologies focus on electric power systems, building equipment, building envelopes (walls, foundations, roofs, attics, and materials), and methods to improve energy efficiency in existing buildings. Transportation systems research is conducted both to improve the quality of civilian transportation and for sponsors within the US military to improve the efficiency of deployment, scheduling, and transportation coordination.

  6. Recent Research Progress in Natural Bioactive Constituents against Lipid Metabolic Diseases.

    Science.gov (United States)

    Nie, Lirong; Song, Hang; He, Ai; Yao, Shun

    2016-01-01

    Lipid metabolic disorder refers to the dyslipidemia in the plasma. Abnormal working or lipid metabolism process leads to supernormal increase of one or multi kinds of lipids in plasma. It is a significant risk factor for many diseases and has become a serious danger to the mankind health. The clinical drugs adjusting lipid levels have a great variety in the market, side effects and adverse reactions. Meanwhile, many Chinese herbal medicines and natural medicines have the unnegligible role of regulating lipid metabolism, which become the research focus of medical workers in past decades. With advantages of fewer side effects, abundant resources and multi-target functions, terrestrial and marine bioactive constituents are proved as one of the important sources of the lead compounds in drug discovery and have been widely applied in the treatment and prevention of lipid metabolic diseases. In this paper, the recent advancements and current status of natural medicinal ingredients mainly based on lipid-lowering activities were reviewed in detail. Moreover, their bioactivity screening and important mechanisms in hyperlipemia progression were summarized and compared. It was also selectively introduced about related structural modification and new drug development on the basis of promising lead compounds. Finally, the current problems and possible prospects of natural constituents against lipid metabolism disorder in the future were discussed.

  7. Mineral cycling in soil and litter arthropod food chains. Annual progress report, February 1, 1983-January 31, 1984

    International Nuclear Information System (INIS)

    Crossley, D.A. Jr.

    1983-01-01

    This annual report describes progress in research on the influence of soil fauna on the general process of terrestrial decomposition. The major goal is to investigate the regulation of decomposition by soil arthropods. Methods have included radioactive tracer measurements of food chain dynamics, rates of nutrient or mineral element flow during decomposition, and simulation modeling. This year's report describes significant progress in defining the influence of soil arthropods in stimulating microbial immobilization of nutrients. Preliminary efforts to define the importance of the soil-litter macroarthropods are also reported

  8. Subseabed disposal program annual report, January-December 1980. Volume II. Appendices (principal investigator progress reports). Part 1

    Energy Technology Data Exchange (ETDEWEB)

    Hinga, K.R. (ed.)

    1981-07-01

    Volume II of the sixth annual report describing the progress and evaluating the status of the Subseabed Disposal Program contains the appendices referred to in Volume I, Summary and Status. Because of the length of Volume II, it has been split into two parts for publication purposes. Part 1 contains Appendices A-Q; Part 2 contains Appendices R-MM. Separate abstracts have been prepared for each appendix for inclusion in the Energy Data Base.

  9. Subseabed disposal program annual report, January-December 1979. Volume II. Appendices (principal investigator progress reports). Part 2 of 2

    International Nuclear Information System (INIS)

    Talbert, D.M.

    1981-04-01

    Volume II of the sixth annual report describing the progress and evaluating the status of the Subseabed Disposal Program contains the appendices referred to in Volume II, Summary and Status. Because of the length of Volume II, it has been split into two parts for publication purposes. Part 1 contains Appendices A-O; Part 2 contains Appendices P-FF. Separate abstracts have been prepared for each appendix for inclusion in the Energy Data Base

  10. Subseabed disposal program annual report, January-December 1980. Volume II. Appendices (principal investigator progress reports). Part 1

    International Nuclear Information System (INIS)

    Hinga, K.R.

    1981-07-01

    Volume II of the sixth annual report describing the progress and evaluating the status of the Subseabed Disposal Program contains the appendices referred to in Volume I, Summary and Status. Because of the length of Volume II, it has been split into two parts for publication purposes. Part 1 contains Appendices A-Q; Part 2 contains Appendices R-MM. Separate abstracts have been prepared for each appendix for inclusion in the Energy Data Base

  11. Subseabed disposal program annual report, January-December 1979. Volume II. Appendices (principal investigator progress reports). Part 1 of 2

    International Nuclear Information System (INIS)

    Talbert, D.M.

    1981-04-01

    Volume II of the sixth annual report describing the progress and evaluating the status of the Subseabed Disposal Program contains the appendices referred to in Volume I, Summary and Status. Because of the length of Volume II, it has been split into two parts for publication purposes. Part 1 contains Appendices A-O; Part 2 contains Appendices P-FF. Separate abstracts have been prepared of each Appendix for inclusion in the Energy Data Base

  12. Brain metabolic maps in Mild Cognitive Impairment predict heterogeneity of progression to dementia

    Directory of Open Access Journals (Sweden)

    Chiara Cerami

    2015-01-01

    Full Text Available [18F]FDG-PET imaging has been recognized as a crucial diagnostic marker in Mild Cognitive Impairment (MCI, supporting the presence or the exclusion of Alzheimer's Disease (AD pathology. A clinical heterogeneity, however, underlies MCI definition. In this study, we aimed to evaluate the predictive role of single-subject voxel-based maps of [18F]FDG distribution generated through statistical parametric mapping (SPM in the progression to different dementia subtypes in a sample of 45 MCI. Their scans were compared to a large normal reference dataset developed and validated for comparison at single-subject level. Additionally, Aβ42 and Tau CSF values were available in 34 MCI subjects. Clinical follow-up (mean 28.5 ± 7.8 months assessed subsequent progression to AD or non-AD dementias. The SPM analysis showed: 1 normal brain metabolism in 14 MCI cases, none of them progressing to dementia; 2 the typical temporo-parietal pattern suggestive for prodromal AD in 15 cases, 11 of them progressing to AD; 3 brain hypometabolism suggestive of frontotemporal lobar degeneration (FTLD subtypes in 7 and dementia with Lewy bodies (DLB in 2 subjects (all fulfilled FTLD or DLB clinical criteria at follow-up; and 4 7 MCI cases showed a selective unilateral or bilateral temporo-medial hypometabolism without the typical AD pattern, and they all remained stable. In our sample, objective voxel-based analysis of [18F]FDG-PET scans showed high predictive prognostic value, by identifying either normal brain metabolism or hypometabolic patterns suggestive of different underlying pathologies, as confirmed by progression at follow-up. These data support the potential usefulness of this SPM [18F]FDG PET analysis in the early dementia diagnosis and for improving subject selection in clinical trials based on MCI definition.

  13. Microbial regulation of glucose metabolism and cell-cycle progression in mammalian colonocytes.

    Directory of Open Access Journals (Sweden)

    Dallas R Donohoe

    Full Text Available A prodigious number of microbes inhabit the human body, especially in the lumen of the gastrointestinal (GI tract, yet our knowledge of how they regulate metabolic pathways within our cells is rather limited. To investigate the role of microbiota in host energy metabolism, we analyzed ATP levels and AMPK phosphorylation in tissues isolated from germfree and conventionally-raised C57BL/6 mice. These experiments demonstrated that microbiota are required for energy homeostasis in the proximal colon to a greater extent than other segments of the GI tract that also harbor high densities of bacteria. This tissue-specific effect is consistent with colonocytes utilizing bacterially-produced butyrate as their primary energy source, whereas most other cell types utilize glucose. However, it was surprising that glucose did not compensate for butyrate deficiency. We measured a 3.5-fold increase in glucose uptake in germfree colonocytes. However, (13C-glucose metabolic-flux experiments and biochemical assays demonstrated that they shifted their glucose metabolism away from mitochondrial oxidation/CO(2 production and toward increased glycolysis/lactate production, which does not yield enough ATPs to compensate. The mechanism responsible for this metabolic shift is diminished pyruvate dehydrogenase (PDH levels and activity. Consistent with perturbed PDH function, the addition of butyrate, but not glucose, to germfree colonocytes ex vivo stimulated oxidative metabolism. As a result of this energetic defect, germfree colonocytes exhibited a partial block in the G(1-to-S-phase transition that was rescued by a butyrate-fortified diet. These data reveal a mechanism by which microbiota regulate glucose utilization to influence energy homeostasis and cell-cycle progression of mammalian host cells.

  14. Recent progress in the metabolic engineering of alkaloids in plant systems.

    Science.gov (United States)

    Glenn, Weslee S; Runguphan, Weerawat; O'Connor, Sarah E

    2013-04-01

    Plant alkaloids have a rich chemical ecology that has been exploited for medicinal purposes for thousands of years. Despite being highly represented within today's pharmacopoeia, relatively little is known about the biosynthesis, regulation and transport of these molecules. Understanding how nature synthesizes plant alkaloids will enhance our ability to overproduce--that is, to metabolically engineer--these medicinally useful compounds as well as new-to-nature compounds (with potentially improved bioactivity) derived from these natural scaffolds. Recent progress in the metabolic engineering of nitrogen-containing plant natural products--specifically the monoterpene indole alkaloids, the benzylisoquinoline alkaloids and the glucosinolates--was made possible through the characterization of various components in both native and engineered enzymatic pathways. The subsequent reconfiguration and tuning of these biological 'parts' has enabled the production of selected products at increasingly higher titers. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. Disturbed tryptophan metabolism correlating to progression and metastasis of esophageal squamous cell carcinoma.

    Science.gov (United States)

    Cheng, Jing; Jin, Hai; Hou, Xiaobei; Lv, Jie; Gao, Xianfu; Zheng, Guangyong

    2017-05-06

    Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignancies worldwide. Lymph node metastasis is the leading cause of death in ESCC patients. To identify early diagnostic and prognostic biomarkers of ESCC and elucidate underlying pathogenesis of the disease, a targeted metabolomics strategy based on liquid chromatography combined with tandem mass spectrometry was applied to explore tryptophan metabolism between ESCC patients, metastatic ESCC patients (mESCC), and healthy controls. Statistical analysis on metabolite expression abundance and compound concentration ratio was conducted to discriminate patients from healthy controls. The concentration ratio of kynurenine, 5-hydroxytryptophan, 5-hydroxyindole-3-acetic acid, 5-hydroxytryptamine to their precursor tryptophan were identified as potential biomarkers, presenting high diagnostic capacity for distinguishing ESCC and mESCC patients from healthy controls. Moreover, a prognostic prediction model was also built on these ratios to distinguish metastasis patients from non-metastasis patients successfully. The high performance of ESCC prediction models suggest that concentration ratios of compounds may be used as biomarkers for early diagnosis and prognosis of the disease. In addition, concentration ratios of compounds show a progressively increased trend from non-metastasis to metastasis patients compared with healthy controls, which is in accordance with process of malignant transformation of ESCC. This interested finding suggests that disturbed tryptophan metabolism is correlated to progression and metastasis of ESCC since concentration ratios of compounds reflect activity of enzymes involved in tryptophan metabolism. This study reveals the impact of tryptophan metabolism to tumorigenesis and metastasis of ESCC, which help biologists investigate mechanism of the disease. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. FY2013 Vehicle and Systems Simulation and Testing R&D Annual Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-02-01

    FY 2013 annual report focuses on the following areas: vehicle modeling and simulation, component and systems evaluations, laboratory and field evaluations, codes and standards, industry projects, and vehicle systems optimization.

  17. Research proposal and annual report No. 16. Part B. Technical progress, September 1, 1975--August 31, 1976

    Energy Technology Data Exchange (ETDEWEB)

    1976-06-01

    Progress is reported on the following research projects: RNA synthesis in yeast; regulation of nitrogen metabolism; biological toxicity of intracellular radioisotope decay; the mechanism of energy conversion in chloroplasts; promoting vibrations in spin-orbital coupling in vibrationally deficient molecules; electronic excitation and hydrogen bonding; macromolecular biophysics; the synthesis and maturation of RNA; electronic response properties of biomolecular systems; chromosome structure and function and chromosome damage; DNA replication and chromosome structure; and influence of phospholipids on the dynamic properties of rhodopsin. (HLW)

  18. Research proposal and annual report No. 16. Part B. Technical progress, September 1, 1975--August 31, 1976

    International Nuclear Information System (INIS)

    1976-01-01

    Progress is reported on the following research projects: RNA synthesis in yeast; regulation of nitrogen metabolism; biological toxicity of intracellular radioisotope decay; the mechanism of energy conversion in chloroplasts; promoting vibrations in spin-orbital coupling in vibrationally deficient molecules; electronic excitation and hydrogen bonding; macromolecular biophysics; the synthesis and maturation of RNA; electronic response properties of biomolecular systems; chromosome structure and function and chromosome damage; DNA replication and chromosome structure; and influence of phospholipids on the dynamic properties of rhodopsin

  19. Analytical Chemistry Division annual progress report for period ending December 31, 1979

    Energy Technology Data Exchange (ETDEWEB)

    Shults, W.D.; Lyon, W.S. (ed.)

    1980-05-01

    The progress is reported in the following sections: analytical methodology, mass and emission spectrometry, technical support, bio-organic analysis, nuclear and radiochemical analysis, and quality assurance. (DLC)

  20. Analytical Chemistry Division annual progress report for period ending December 31, 1979

    International Nuclear Information System (INIS)

    Shults, W.D.; Lyon, W.S.

    1980-05-01

    The progress is reported in the following sections: analytical methodology, mass and emission spectrometry, technical support, bio-organic analysis, nuclear and radiochemical analysis, and quality assurance

  1. Annual Research Progress Report. Fiscal Year 2003. Volume’s 1 and 2

    Science.gov (United States)

    2003-01-01

    similar responses in lipid metabolism when compared to non-diabetics, they also showed modest improvements in glucose control. Contrary to current...significant weight loss occurred without noticeable adverse effects on lipids , glucose metabolism , or blood pressure, but that the loss was probably actually...3/26/2002) 02-14010E ExemptCumings, Mark D., MAJ MC. The Significance of Postprandial Reflux in Upright Reflux Disease. (3/20/2002) 02-14011

  2. Current progress of targetron technology: development, improvement and application in metabolic engineering.

    Science.gov (United States)

    Liu, Ya-Jun; Zhang, Jie; Cui, Gu-Zhen; Cui, Qiu

    2015-06-01

    Targetrons are mobile group II introns that can recognize their DNA target sites by base-pairing RNA-DNA interactions with the aid of site-specific binding reverse transcriptases. Targetron technology stands out from recently developed gene targeting methods because of the flexibility, feasibility, and efficiency, and is particularly suitable for the genetic engineering of difficult microorganisms, including cellulolytic bacteria that are considered promising candidates for biomass conversion via consolidated bioprocessing. Along with the development of the thermotargetron method for thermophiles, targetron technology becomes increasingly important for the metabolic engineering of industrial microorganisms aiming at biofuel/chemical production. To summarize the current progress of targetron technology and provide new insights on the use of the technology, this paper reviews the retrohoming mechanisms of both mesophilic and thermophilic targetron methods based on various group II introns, investigates the improvement of targetron tools for high target efficiency and specificity, and discusses the current applications in the metabolic engineering for bacterial producers. Although there are still intellectual property and technical restrictions in targetron applications, we propose that targetron technology will contribute to both biochemistry research and the metabolic engineering for industrial productions. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. NAFLD in the absence of metabolic syndrome: different epidemiology, pathogenetic mechanisms, risk factors for disease progression?

    Science.gov (United States)

    Yilmaz, Yusuf

    2012-02-01

    Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that have been associated with an increased risk of developing nonalcoholic fatty liver disease (NAFLD). Insulin resistance and central obesity are the key components of MetS, ultimately leading to liver fat accumulation and the subsequent development of necroinflammatory liver injury. However, the origin and nature of the metabolic stressors responsible for stimulating the progression of simple steatosis to nonalcoholic steatohepatitis (NASH) remain to be clearly identified. In addition, epidemiologic research on the association between MetS and NAFLD has provided only limited information to guide the development of targeted interventions, in particular, nutrition and pharmacologic prevention programs. This review summarizes the evidence supporting the proposal that NAFLD is not invariably associated with the presence of MetS, and mechanisms other than insulin resistance may contribute to the chronic inflammatory processes that underpin the development of liver fat accumulation and the subsequent architectural distortion of the liver. A special focus is given to increased hemoglobin as a risk factor for the development of NAFLD in the absence of MetS. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  4. Dissolved organic matter and lake metabolism. Technical progress report, 1 July 1977--30 June 1978

    Energy Technology Data Exchange (ETDEWEB)

    Wetzel, R.G.

    1978-01-01

    Interactions of dissolved organic matter with inorganic nutrient cycling and regulation of the photosynthetic and decompositional metabolism of micro- and macroflora remains the focal point of these studies. Major efforts are directed towards the sources, fates, pathways, and interactions of dissolved organic matter in inorganic chemical cycling; allochthonous sources, metabolism en route, and inputs to the lake systems of increasing stages of eutrophication; and the relationships of these compounds to the nutrient physiology and metabolism of phytoplankton, sessile algae, macrophytes, and bacterial populations of the littoral zones and wetlands of the drainage basin. Analyses of regulatory mechanisms of growth and rates of carbon cycling center on evaluation of quantitative control interactions among the microflora of the pelagial zones of seversal lakes of progressively greater eutrophy, littoral photosynthetic producer-decomposer complex, and allochthonous inorganic--organic influxes and their biotic processing. The underlying thesis is that quantification of the dynamic carbon fluxes among these components and their rate control mechanisms by physical and chemical factors are fundamental to elucidation of the rate functions of lake eutrophication.

  5. Metabolic acidosis is common and associates with disease progression in children with chronic kidney disease.

    Science.gov (United States)

    Harambat, Jérôme; Kunzmann, Kevin; Azukaitis, Karolis; Bayazit, Aysun K; Canpolat, Nur; Doyon, Anke; Duzova, Ali; Niemirska, Anna; Sözeri, Betul; Thurn-Valsassina, Daniela; Anarat, Ali; Bessenay, Lucie; Candan, Cengiz; Peco-Antic, Amira; Yilmaz, Alev; Tschumi, Sibylle; Testa, Sara; Jankauskiene, Augustina; Erdogan, Hakan; Rosales, Alejandra; Alpay, Harika; Lugani, Francesca; Arbeiter, Klaus; Mencarelli, Francesca; Kiyak, Aysel; Dönmez, Osman; Drozdz, Dorota; Melk, Anette; Querfeld, Uwe; Schaefer, Franz

    2017-12-01

    Recent studies in adult chronic kidney disease (CKD) suggest that metabolic acidosis is associated with faster decline in estimated glomerular filtration rate (eGFR). Alkali therapies improve the course of kidney disease. Here we investigated the prevalence and determinants of abnormal serum bicarbonate values and whether metabolic acidosis may be deleterious to children with CKD. Associations between follow-up serum bicarbonate levels categorized as under 18, 18 to under 22, and 22 or more mmol/l and CKD outcomes in 704 children in the Cardiovascular Comorbidity in Children with CKD Study, a prospective cohort of pediatric patients with CKD stages 3-5, were studied. The eGFR and serum bicarbonate were measured every six months. At baseline, the median eGFR was 27 ml/min/1.73m 2 and median serum bicarbonate level 21 mmol/l. During a median follow-up of 3.3 years, the prevalence of metabolic acidosis (serum bicarbonate under 22 mmol/l) was 43%, 60%, and 45% in CKD stages 3, 4, and 5, respectively. In multivariable analysis, the presence of metabolic acidosis as a time-varying covariate was significantly associated with log serum parathyroid hormone through the entire follow-up, but no association with longitudinal growth was found. A total of 211 patients reached the composite endpoint (ESRD or 50% decline in eGFR). In a multivariable Cox model, children with time-varying serum bicarbonate under 18 mmol/l had a significantly higher risk of CKD progression compared to those with a serum bicarbonate of 22 or more mmol/l (adjusted hazard ratio 2.44; 95% confidence interval 1.43-4.15). Thus, metabolic acidosis is a common complication in pediatric patients with CKD and may be a risk factor for secondary hyperparathyroidism and kidney disease progression. Copyright © 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

  6. Idaho Natural Production Monitoring and Evaluation : Annual Progress Report February 1, 2007 - January 31, 2008.

    Energy Technology Data Exchange (ETDEWEB)

    Copeland, Timothy; Johnson, June; Putnam, Scott

    2008-12-01

    River stocks of steelhead and spring/summer Chinook salmon still have significant natural reproduction and thus are the focal species for this project's investigations. The overall goal is to monitor the abundance, productivity, distribution, and stock-specific life history characteristics of naturally produced steelhead trout and Chinook salmon in Idaho (IDFG 2007). We have grouped project tasks into three objectives, as defined in our latest project proposal and most recent statement of work. The purpose of each objective involves enumerating or describing individuals within the various life stages of Snake River anadromous salmonids. By understanding the transitions between life stages and associated controlling factors, we hope to achieve a mechanistic understanding of stock-specific population dynamics. This understanding will improve mitigation and recovery efforts. Objective 1. Measure 2007 adult escapement and describe the age structure of the spawning run of naturally produced spring/summer Chinook salmon passing Lower Granite Dam. Objective 2. Monitor the juvenile production of Chinook salmon and steelhead trout for the major population groups (MPGs) within the Clearwater and Salmon subbasins. Objective 3. Evaluate life cycle survival and the freshwater productivity/production of Snake River spring/summer Chinook salmon. There are two components: update/refine a stock-recruit model and estimate aggregate smolt-to-adult survival. In this annual progress report, we present technical results for work done during 2007. Part 2 contains detailed results of INPMEP aging research and estimation of smolt-to-adult return rates for wild and naturally produced Chinook salmon (Objectives 1 and 3). Part 3 is a report on the ongoing development of a stock-recruit model for the freshwater phase of spring/summer Chinook salmon in the Snake River basin (Objective 3). Part 4 is a summary of the parr density data (Objective 2) collected in 2007 using the new site selection

  7. Gitelman's syndrome with vomiting manifested by severe metabolic alkalosis and progressive renal insufficiency.

    Science.gov (United States)

    Lee, Jong-Ho; Lee, Jeonghwan; Han, Jin Suk

    2013-11-01

    Gitelman's syndrome is an autosomal recessive salt-losing tubulopathy showing hypokalemic hypomagnesemic hypocalciuria with metabolic alkalosis and hyperreninemic hyperaldosteronism. This syndrome is caused by mutations in the SLC12A3 gene that encodes sodium-chloride cotransporter expressed at the apical membrane of renal distal convoluted tubule. Symptoms and renal outcomes of Gitelman's syndrome are, in general, mild and benign, and renal insufficiency from Gitelman's syndrome associated with long-standing hypokalemia and volume depletion is extremely rare. Herein, we report a 27-year-old male patient with Gitelman's syndrome who manifested renal failure, hypokalemia, severe metabolic alkalosis and altered mentality. About one year ago, the patient had been transferred to Seoul National University Hospital, because of unsolved hypokalemia, and was diagnosed as Gitelman's syndrome by clinical features and genetic analysis of the SLC12A3 gene. The patient carries a missense mutation at one allele of SLC12A3 gene (c.781C>T, p.Arg261Cys). His mother is also heterozygous for the same mutation and she had a history of hypokalemia. On this admission, the patient had recurrent bouts of vomiting induced by psychiatric eating disorder and showed severe volume depletion with hypotension, azotemia and metabolic alkalosis. Intense hydration therapy and emergency hemodialysis transiently improved his fluid-electrolyte imbalance and renal function. However, renal dysfunction progressively deteriorated despite the medical treatment. Our findings suggest that even in Gitelman's syndrome, constant monitoring for volume status and other comorbid conditions should be employed to prevent progressive renal injury.

  8. Environmental Sciences Division annual progress report for period ending September 30, 1983

    Energy Technology Data Exchange (ETDEWEB)

    1984-04-01

    This annual report summarizes activities in the Aquatic Ecology, Earth Sciences, Environmental Analyses, and Terrestrial Ecology sections, as well as in the Fossil Energy, Biomass, Low-Level Waste Research and Management, and Global Carbon Cycle Programs. Separate abstracts have been prepared for each section. (ACR)

  9. Environmental Sciences Division annual progress report for period ending September 30, 1983

    International Nuclear Information System (INIS)

    1984-04-01

    This annual report summarizes activities in the Aquatic Ecology, Earth Sciences, Environmental Analyses, and Terrestrial Ecology sections, as well as in the Fossil Energy, Biomass, Low-Level Waste Research and Management, and Global Carbon Cycle Programs. Separate abstracts have been prepared for each section

  10. Joint Services Electronics Program: Annual Progress Report Number 103, 1 October 1988 - 31 July 1989 (Harvard University, Cambridge, Massachusetts)

    Science.gov (United States)

    1989-07-31

    22217 Ill TITLE (Include Security Classification) Annual Progress Report No. 103 12 PERSONAL AUTHOR(S) * Prof. Michael Tinkham 13a. TYPE Of REPORT 13b...Buffers," in Queuing Networks with Blocking (eds. H. Perros and T. Altiok) (North Holland), to appear. H. Chen and D. D. Yao, "Derivatives of the...discussed under Topic IV.8. 74 A A rigorous analysis of the V-conical antenna, designed as a feeding antenna for use in the experimental study of EM

  11. [Regulation of terpene metabolism]. Annual progress report, March 15, 1991--March 14, 1992

    Energy Technology Data Exchange (ETDEWEB)

    Croteau, R.

    1992-12-31

    This report describes accomplishments over the past year on understanding of terpene synthesis in mint plants and sage. Specifically reported are the fractionation of 4-S-limonene synthetase, the enzyme responsible for the first committed step to monoterpene synthesis, along with isolation of the corresponding RNA and DNA cloning of its gene; the localization of the enzyme within the oil glands, regulation of transcription and translation of the synthetase, the pathway to camphor biosynthesis,a nd studies on the early stages and branch points of the isoprenoid pathway.

  12. Environmental Sciences Division. Annual progress report for period ending September 30, 1979

    International Nuclear Information System (INIS)

    1980-03-01

    Progress for the period ending September 30, 1979 by the Environmental Sciences Division is reported. Sections reporting include terrestrial ecoloy; earth sciences; environmental resources; aquatic ecology; synthetic fuels; nuclear program; environmental impacts program; ecosystem studies; and burial ground technology

  13. University of Florida, University research program in robotics. Annual technical progress report

    International Nuclear Information System (INIS)

    Crane, C.D. III; Tulenko, J.S.

    1994-05-01

    Progress is reported in the areas of environmental hardening, database, world modeling, vision, man-machine interface, advanced liquid metal reactor inspection robot, and articulated transporter/manipulator system (ATMS) development

  14. University of Florida, University research program in robotics. Annual technical progress report

    Energy Technology Data Exchange (ETDEWEB)

    Crane, C.D. III; Tulenko, J.S.

    1994-05-01

    Progress is reported in the areas of environmental hardening, database, world modeling, vision, man-machine interface, advanced liquid metal reactor inspection robot, and articulated transporter/manipulator system (ATMS) development.

  15. ORNL nuclear waste programs annual progress report for period ending September 30, 1982

    International Nuclear Information System (INIS)

    1983-05-01

    Research progress is reported in 20 activities under the headings: spent fuels, defense waste management, commercial waste management, remedial action, and conventional reactors. Separate entries were prepared for each activity

  16. ORNL nuclear waste programs annual progress report for period ending September 30, 1982

    Energy Technology Data Exchange (ETDEWEB)

    1983-05-01

    Research progress is reported in 20 activities under the headings: spent fuels, defense waste management, commercial waste management, remedial action, and conventional reactors. Separate entries were prepared for each activity.

  17. Gas-Cooled Reactor Programs annual progress report for period ending December 31, 1973

    International Nuclear Information System (INIS)

    Kasten, P.R.; Coobs, J.H.; Lotts, A.L.

    1976-04-01

    Progress is summarized in studies relating to HTGR fuel reprocessing, refabrication, and recycle; HTGR fuel materials development and performance testing; HTGR PCRV development; HTGR materials investigations; HTGR fuel chemistry; HTGR safety studies; and GCFR irradiation experiments and steam generator modeling

  18. Cancer and birth defects surveillance system for communities around the Savannah River Site. Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Dunbar, J.B.

    1994-05-01

    The US DOE funded this grant to the Medical University of South Carolina for a cancer and birth defects registry for an initial three year period which was completed as of April 29, 1994. While this Technical Progress Report is prepared principally to document the activities of year 03, it also summarizes the accomplishments of the first two years in order to put into perspective the energy and progress of the program over the entire three year funding cycle.

  19. Nuclear-chemistry research and spectroscopy with radioactive sources. Eighteenth annual progress report

    International Nuclear Information System (INIS)

    Fink, R.W.

    1982-01-01

    Progress is reported on nuclear spectroscopy studies including lifetimes of the g/sub 7/2/ shell-model intruder states in 107 109 Ag, lifetime of the new /sup 187m/Au isomer, the decay of 187 Au - 187 Pt, decay of /sup 201m,g/Po, 203 At, and 125 Ba, and L-shell orbital EC probability and decay energy in 207 Bi decay. Also progress on nuclear model calculations of nuclear structure is reported

  20. Cancer and birth defects surveillance system for communities around the Savannah River Site. Annual progress report

    International Nuclear Information System (INIS)

    Dunbar, J.B.

    1994-05-01

    The US DOE funded this grant to the Medical University of South Carolina for a cancer and birth defects registry for an initial three year period which was completed as of April 29, 1994. While this Technical Progress Report is prepared principally to document the activities of year 03, it also summarizes the accomplishments of the first two years in order to put into perspective the energy and progress of the program over the entire three year funding cycle

  1. Annual Continuation And Progress Report For Nuclear Theory At Lawrence Livermore National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Ormand, W. E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Quaglioni, S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Schunck, N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Vogt, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Vranas, P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-10-26

    Nuclear Theory research under the auspices of the Department of Energy (DOE) Office of Nuclear Physics (NP) is conducted within several funding sources and projects. These include base funding, and early career award, and a collaborative SciDAC-­3 award that is jointly funded by DOE/NP and the Advanced Simulations and Computations (ASC) effort within the National Nuclear Security Agency (NNSA). Therefore, this annual report is organized within the three primary sections covering these projects.

  2. US Army Institute of Surgical Research Annual Research Progress Report FY 1982.

    Science.gov (United States)

    1982-10-01

    Nutritional demands imposed by stress. Dairy Council Digest 51: (Nov/Dec), 1980 5. Nichols B: Nutrition and infection. South Med J 71: 705, 1978 6...Lindberg RB: Epidemics of Enterobacteriaceae in Burn Patient Infections. Annual Meeting of the South African Burn Association, Skukuza, South Africo, 5...Parentheses indicate comparison vs. BT for BLPX and vs. MELsc for MELscPX. 76 In Experiment 3 (Fig. 3), average water intake /hamster/evening- night (1600

  3. Tumor-stroma metabolic relationship based on lactate shuttle can sustain prostate cancer progression

    International Nuclear Information System (INIS)

    Sanità, Patrizia; Capulli, Mattia; Teti, Anna; Galatioto, Giuseppe Paradiso; Vicentini, Carlo; Chiarugi, Paola; Bologna, Mauro; Angelucci, Adriano

    2014-01-01

    correlation between stromal MCT4 and tumor MCT1 expression. Our data demonstrated that PCa progression may benefit of MCT1 expression in tumor cells and of MCT4 in tumor-associated stromal cells. Therefore, MCTs may result promising therapeutic targets in different phases of neoplastic transformation according to a strategy aimed to contrast the energy metabolic adaptation of PCa cells to stressful environments

  4. Measuring cell cycle progression kinetics with metabolic labeling and flow cytometry.

    Science.gov (United States)

    Fleisig, Helen; Wong, Judy

    2012-05-22

    metabolic processes for each cell cycle stage are useful in blocking the progression of the cell cycle to the next stage. For example, the ribonucleotide reductase inhibitor hydroxyurea halts cells at the G1/S juncture by limiting the supply of deoxynucleotides, the building blocks of DNA. Other notable chemicals include treatment with aphidicolin, a polymerase alpha inhibitor for G1 arrest, treatment with colchicine and nocodazole, both of which interfere with mitotic spindle formation to halt cells in M phase and finally, treatment with the DNA chain terminator 5-fluorodeoxyridine to initiate S phase arrest. Treatment with these chemicals is an effective means of synchronizing an entire population of cells at a particular phase. With removal of the chemical, cells rejoin the cell cycle in unison. Treatment of the test agent following release from the cell cycle blocking chemical ensures that the drug response elicited is from a uniform, cell cycle stage-specific population. However, since many of the chemical synchronizers are known genotoxic compounds, teasing apart the participation of various response pathways (to the synchronizers vs. the test agents) is challenging. Here we describe a metabolic labeling method for following a subpopulation of actively cycling cells through their progression from the DNA replication phase, through to the division and separation of their daughter cells. Coupled with flow cytometry quantification, this protocol enables for measurement of kinetic progression of the cell cycle in the absence of either mechanically- or chemically- induced cellular stresses commonly associated with other cell cycle synchronization methodologies. In the following sections we will discuss the methodology, as well as some of its applications in biomedical research.

  5. Environmental Management Science Program awards. Fiscal year 1997 annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, A. [ed.; Benner, W.H.; DePaolo, D.J.; Faybishenko, B.; Majer, E.L.; Pallavicini, M.; Russo, R.E.; Shultz, P.G.; Wan, J.

    1997-10-01

    Lawrence Berkeley National Laboratory was awarded eight Environmental Management Science Program (EMSP) research grants in Fiscal Year 1996. This report summarizes the progress of each grant in addressing significant DOE site cleanup issues after completion of the first year of research. The technical progress made to date in each of the research projects is described in greater detail in individual progress reports. The focus of the research projects covers a diversity of areas relevant to site cleanup, including bioremediation, health effects, characterization, and mixed waste. Some of the projects cut across a number of focus areas. Three of the projects are directed toward characterization and monitoring at the Idaho National Engineering and Environmental Laboratory, as a test case for application to other sites.

  6. Environmental Management Science Program awards. Fiscal year 1997 annual progress report

    International Nuclear Information System (INIS)

    Simmons, A.; Benner, W.H.; DePaolo, D.J.; Faybishenko, B.; Majer, E.L.; Pallavicini, M.; Russo, R.E.; Shultz, P.G.; Wan, J.

    1997-10-01

    Lawrence Berkeley National Laboratory was awarded eight Environmental Management Science Program (EMSP) research grants in Fiscal Year 1996. This report summarizes the progress of each grant in addressing significant DOE site cleanup issues after completion of the first year of research. The technical progress made to date in each of the research projects is described in greater detail in individual progress reports. The focus of the research projects covers a diversity of areas relevant to site cleanup, including bioremediation, health effects, characterization, and mixed waste. Some of the projects cut across a number of focus areas. Three of the projects are directed toward characterization and monitoring at the Idaho National Engineering and Environmental Laboratory, as a test case for application to other sites

  7. Mechanism involved in trichloroethylene-induced liver cancer: Importance to environmental cleanup. 1997 annual progress report

    International Nuclear Information System (INIS)

    Bull, R.J.

    1997-01-01

    'The Pacific Northwest National Lab. was awarded ten (10) Environmental Management Science Program (EMSP) research grants in Fiscal Year 1996. This section gives a summary of how each grant is addressing significant DOE cleanup issues, including those at the Hanford Site. The technical progress made to date in each of these research projects is addressed in more detail in the individual progress reports contained in this document. This research is primarily focused in three areas-Tank Waste Remediation, Soil and Groundwater Cleanup, and Health Effects.'

  8. Report to Congress: 1995 Annual report on low-level radioactive waste management progress

    International Nuclear Information System (INIS)

    1996-06-01

    This report is prepared in response to the Low-Level Radioactive Waste Policy Act, Public Law 96-573, 1980, as amended by the Low-Level Radioactive Waste Policy Amendments Act of 1985, Public Law 99-240. The report summarizes the progress of states and compact regions during calendar year 1995 in establishing new disposal facilities for commercially-generated low-level radioactive waste. The report emphasizes significant issues and events that have affected progress, and also includes an introduction that provides background information and perspective on United States policy for low-level radioactive waste disposal

  9. Mechanism involved in trichloroethylene-induced liver cancer: Importance to environmental cleanup. 1997 annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Bull, R.J.

    1997-06-01

    'The Pacific Northwest National Lab. was awarded ten (10) Environmental Management Science Program (EMSP) research grants in Fiscal Year 1996. This section gives a summary of how each grant is addressing significant DOE cleanup issues, including those at the Hanford Site. The technical progress made to date in each of these research projects is addressed in more detail in the individual progress reports contained in this document. This research is primarily focused in three areas-Tank Waste Remediation, Soil and Groundwater Cleanup, and Health Effects.'

  10. Dissolved organic matter and lake metabolism. Technical progress report, 1 July 1978--30 Jun 1979

    Energy Technology Data Exchange (ETDEWEB)

    Wenzel, R.G.

    1979-01-01

    Progress is reported in continuing investigations focused on integrated studies of the qualitative and quantitative cycling and metabolism of particulate and dissolved organic carbon in lakes and their inflow sources (surface and subsurface). Emphasis is placed on the sources, fates, and interactions of dissolved and particulate organic matter in relation to: (a) inorganic chemical cycling, (b) allochthonous loading to the lake system, and (c) the coupled nutrient physiology and metabolism of phytoplankton, bacterial populations, macrophytes, and attendant sessile algal-bacterial communities. Regulatory mechanisms of growth and rates of carbon and nutrient cycling are being evaluated among the (a) inorganic-organic influxes of allochthonous sources as they are controlled by wetland-littoral communities, (b) the littoral photosynthetic producer-decomposer complex, and (c) the microflora of the pelagial zone. Quantification of carbon fluxes among these components and control mechanisms is fundamental to elucidation of the rate functions of lake eutrophication. The integrated studies addressing these multifacted objectives are summarized in three summary diagrams.

  11. Global reprogramming of transcription and metabolism in Medicago truncatula during progressive drought and after rewatering

    Science.gov (United States)

    Zhang, Ji-Yi; Cruz de Carvalho, Maria H; Torres-Jerez, Ivone; Kang, Yun; Allen, Stacy N; Huhman, David V; Tang, Yuhong; Murray, Jeremy; Sumner, Lloyd W; Udvardi, Michael K

    2014-01-01

    Medicago truncatula is a model legume forage crop native to the arid and semi-arid environments of the Mediterranean. Given its drought-adapted nature, it is an ideal candidate to study the molecular and biochemical mechanisms conferring drought resistance in plants. Medicago plants were subjected to a progressive drought stress over 14 d of water withholding followed by rewatering under controlled environmental conditions. Based on physiological measurements of plant water status and changes in morphology, plants experienced mild, moderate and severe water stress before rehydration. Transcriptome analysis of roots and shoots from control, mildly, moderately and severely stressed, and rewatered plants, identified many thousands of genes that were altered in expression in response to drought. Many genes with expression tightly coupled to the plant water potential (i.e. drought intensity) were identified suggesting an involvement in Medicago drought adaptation responses. Metabolite profiling of drought-stressed plants revealed the presence of 135 polar and 165 non-polar compounds in roots and shoots. Combining Medicago metabolomic data with transcriptomic data yielded insight into the regulation of metabolic pathways operating under drought stress. Among the metabolites detected in drought-stressed Medicago plants, myo-inositol and proline had striking regulatory profiles indicating involvement in Medicago drought tolerance. Global transcriptional and metabolic responses to drought and rewatering were investigated in Medicago truncatula, a naturally drought-adapted model legume species. Integration of metabolomic and transcriptomic data yielded insights into the regulation of metabolic pathways underlying drought-stress adaptation. Many genes and metabolites with expression tightly coupled to drought intensity were identified, suggesting active involvement in Medicago drought resistance. These could prove useful targets for future translational approaches to improve

  12. Research in elementary particle physics at the University of Florida: Annual progress report

    International Nuclear Information System (INIS)

    1988-01-01

    This is a progress report on the Elementary Particle Physics program at the University of Florida. The program has five tasks covering a broad range of topics in theoretical and experimental high energy physics: Theoretical Elementary Particle Physics, Experimental High Energy Physics, Axion Search, Detector Development, and Computer Requisition

  13. Comparative study of radiation, chemical, and aging effects on viral transformation. Annual progress report, 1975

    Energy Technology Data Exchange (ETDEWEB)

    Coggin, J.H. Jr.

    1976-03-31

    Progress is reported on the following research projects: evaluation of isotopic antiglobulin test (IAT) to detect tumor associated antigens using antisera induced by x-irradiated tumor cells; development of cytotoxic antibody for embryonic antigens (EA); acrylamide gel cell culture assay for transformation; and evaluation of 3-MCA induced sarcomas for TSTA and cross-reacting antigens. (HLW)

  14. Research in radiobiology. Annual report of work in progress in the internal irradiation program

    International Nuclear Information System (INIS)

    Miller, S.C.

    1983-01-01

    Research progress on studies of the effects of internally deposited radionuclides in dogs, mice, and humans is reported. The studies include toxicity of plutonium 239, radium 226, and radium 224, the kinetics of actinides in beagles, and dosimetry of internal emitters

  15. Chemistry Division annual progress report for period ending January 31, 1984

    Energy Technology Data Exchange (ETDEWEB)

    1984-05-01

    Progress is reported in the following fields: coal chemistry, aqueous chemistry at high temperatures and pressures, geochemistry, high-temperature chemistry and thermodynamics of structural materials, chemistry of transuranium elements and compounds, separations chemistry, elecrochemistry, catalysis, chemical physics, theoretical chemistry, nuclear waste chemistry, chemistry of hazardous chemicals, and thermal energy storage.

  16. Nuclear powered satellite studies. Annual progress report, July 1, 1977--June 30, 1978

    International Nuclear Information System (INIS)

    Kaplan, M.H.

    1978-06-01

    Progress achieved during the reporting period is reported. Discussions of several pertinent aspects are included, e.g., schedule, personnel, technology developments, and plans. The reporting period represents the second year of activities of a project which is designed to provide continuing support in the area of nuclear space power technology. Important results are summarized

  17. Comparative study of radiation, chemical, and aging effects on viral transformation. Annual progress report, 1975

    International Nuclear Information System (INIS)

    Coggin, J.H. Jr.

    1976-01-01

    Progress is reported on the following research projects: evaluation of isotopic antiglobulin test (IAT) to detect tumor associated antigens using antisera induced by x-irradiated tumor cells; development of cytotoxic antibody for embryonic antigens (EA); acrylamide gel cell culture assay for transformation; and evaluation of 3-MCA induced sarcomas for TSTA and cross-reacting antigens

  18. Annual progress report of the Condensed Matter Physics and Chemistry Department 1 January - 31 December 2000

    DEFF Research Database (Denmark)

    2001-01-01

    The Condensed Matter Physics and Chemistry Department is concerned with both fundamental and applied research into the physical and chemical properties of materials. The principal activities in the year 2000 are presented in this progress report. Theresearch in physics is concentrated on neutron...

  19. Annual progress report of the Condensed Matter Physics and Chemistry Department 1 January - 31 December 1999

    DEFF Research Database (Denmark)

    2000-01-01

    The Condensed Matter Physics and Chemistry Department is concerned with both fundamental and applied research into the physical and chemical properties of materials. The principal activities in the year 1999 are presented in this progress report. Theresearch in physics is concentrated on neutron...

  20. [Shippingport Station Decommissioning Project]: FY 1987 annual progress report, October 1, 1986-September 30, 1987

    International Nuclear Information System (INIS)

    1988-01-01

    This report presents progress on the Shippingport Station Decommissioning Project for FY 1987. There are two main topics: Project Management and Decommissioning Project Activities. Changes from technical and managerial concepts developed in the original Decommissioning Plan are presented with the related technical, economic, or schedule considerations. 3 refs., 9 figs., 4 tabs

  1. Savannah River Ecology Laboratory annual technical progress report of ecological research, period ending July 31, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Vaitkus, M.R.; Wein, G.R. [eds.; Johnson, G.

    1993-11-01

    This progress report gives an overview of research programs at the Savannah River Site. Topics include; environmental operations support, wood stork foraging and breeding, defense waste processing, environmental stresses, alterations in the environment due to pollutants, wetland ecology, biodiversity, pond drawdown studies, and environmental toxicology.

  2. Task I. Basic mirror studies. Task II. Basic tokamak studies. Annual progress report

    International Nuclear Information System (INIS)

    Smullin, L.D.; Bekefi, G.; Porkolab, M.

    1979-01-01

    Brief discussions of research progress are given for each of the following areas: (1) building equipment, (2) rf heating, (3) interferometry, (4) gas puffing, (5) mm collective scattering, (6) uv spectroscopy, (7) soft x radiation, (8) charge exchange, and (9) Thomson scattering

  3. [Molecular cloning and structural characteristics of the R complex of maize]. Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    1992-07-01

    Studies on the R complex in Maize continued Progress is discussed in the following areas: Establishing identity of R components and cloning of R components; CO allele origin; molecular organization of R-r complex; NCO allele origin; genetic analysis of R-r complex; studies of the Sn locus and reverse paramutation.

  4. Annual progress report FY 1977. [Computer calculations of light water reactor dynamics and safety

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, K.F.; Henry, A.F.

    1977-07-01

    Progress is summarized in a project directed toward development of numerical methods suitable for the computer solution of problems in reactor dynamics and safety. Specific areas of research include methods of integration of the time-dependent diffusion equations by finite difference and finite element methods; representation of reactor properties by various homogenization procedures; application of synthesis methods; and development of response matrix techniques.

  5. Analytical Chemistry Division annual progress report for period ending December 31, 1984

    International Nuclear Information System (INIS)

    Lyon, W.S.

    1985-04-01

    Progress reports are presented for the following sections: analytical methodology; mass and emission spectroscopy; radioactive materials analysis; bio/organic analysis; and general and environmental analysis; quality assurance, safety, and tabulation analyses. In addition a list of publications and oral presentations and supplemental activities are included

  6. Analytical Chemistry Division annual progress report for period ending December 31, 1983

    International Nuclear Information System (INIS)

    Lyon, W.S.

    1984-05-01

    Progress and activities are reported in: analytical methodology, mass and emission spectrometry, radioactive materials analysis, bio/organic analysis, general and environmental analysis, and quality assurance and safety. Supplementary activities are also discussed, and a bibliography of publications is also included

  7. Analytical Chemistry Division annual progress report for period ending December 31, 1983

    Energy Technology Data Exchange (ETDEWEB)

    Lyon, W.S. (ed.)

    1984-05-01

    Progress and activities are reported in: analytical methodology, mass and emission spectrometry, radioactive materials analysis, bio/organic analysis, general and environmental analysis, and quality assurance and safety. Supplementary activities are also discussed, and a bibliography of publications is also included. (DLC)

  8. Analytical Chemistry Division annual progress report for period ending December 31, 1984

    Energy Technology Data Exchange (ETDEWEB)

    Lyon, W.S. (ed.)

    1985-04-01

    Progress reports are presented for the following sections: analytical methodology; mass and emission spectroscopy; radioactive materials analysis; bio/organic analysis; and general and environmental analysis; quality assurance, safety, and tabulation analyses. In addition a list of publications and oral presentations and supplemental activities are included.

  9. Shippingport Station Decommissioning Project: FY 1986 annual progress report, October 1, 1985 through September 30, 1986

    International Nuclear Information System (INIS)

    1987-01-01

    This report presents progress on the Shippingport Station Decommissioning Project for FY 1986. There are two main topics: Project Management and Decommissioning Project Activities. Changes from technical and managerial concepts developed in the original Decommissioning Plan are presented with the related technical, economic, or schedule considerations. 9 refs., 4 figs., 3 tabs

  10. Dissolved organic matter and lake metabolism. Technical progress report, 1 July 1979-30 June 1980

    Energy Technology Data Exchange (ETDEWEB)

    Wetzel, R.G.

    1980-01-01

    Progress in research to evaluate the impact of utilization of fossil fuels on surface water is reported. Analyses of regulatory mechanisms of growth and rates of carbon cycling center on evaluation of quantitative control interactions among the microflora of the pelagial zones of several lakes of progressively greater eutrophy, littoral photosynthetic producer-decomposer complex, and allochthonous inorganic-organic influxes and their biotic processing. The underlying thesis is that quantification of the dynamic carbon fluxes among these components and their rate control mechanisms by physical and chemical factors are fundamental to elucidation of the rate functions of lake eutrophication. A major portion of the research has been directed towards the fate and nutrient mechanisms regulating qualitative and quantitative utilization and losses of organic carbon synthesized within lakes and their drainage basins. It has become increasingly apparent that the wetland and littoral flora, and attendant epiphytic and benthic microflora, have major regulatory controls on biogeochemical cycling of whole lake systems. A major effort on factors regulating the metabolism of littoral macrophytes and attached algae has been coupled to integrated studies on their decomposition and the fate of detrital dissolved and particulate organic matter. These organic products are being coupled to influences on enzymatic activity and inorganic nutrient cycling.

  11. Walla Walla River Fish Passage Operations Project : Annual Progress Report October 2007 - September 2008.

    Energy Technology Data Exchange (ETDEWEB)

    Bronson, James P.; Duke, Bill; Loffink, Ken

    2008-12-30

    In the late 1990s, the Confederated Tribes of the Umatilla Indian Reservation, Oregon Department of Fish and Wildlife, and Washington Department of Fish and Wildlife, along with many other agencies, began implementing fisheries restoration activities in the Walla Walla Basin. An integral part of these efforts is to alleviate the inadequate fish migration conditions in the basin. Migration concerns are being addressed by removing diversion structures, constructing fish passage facilities, implementing minimum instream flow requirements, and providing trap and haul efforts when needed. The objective of the Walla Walla River Fish Passage Operations Project is to increase the survival of migrating adult and juvenile salmonids in the Walla Walla River basin. The project is responsible for coordinating operation and maintenance of ladders, screen sites, bypasses, trap facilities, and transportation equipment. In addition, the project provides technical input on passage and trapping facility design, operation, and criteria. Operation of the various passage facilities and passage criteria guidelines are outlined in an annual operations plan that the project develops. Beginning in March of 2007, two work elements from the Walla Walla Fish Passage Operations Project were transferred to other projects. The work element Enumeration of Adult Migration at Nursery Bridge Dam is now conducted under the Walla Walla Basin Natural Production Monitoring and Evaluation Project and the work element Provide Transportation Assistance is conducted under the Umatilla Satellite Facilities Operation and Maintenance Project. Details of these activities can be found in those project's respective annual reports.

  12. Radioecology of natural systems in Colordao. Fourteenth annual progress report, May 1, 1975--July 31, 1976

    International Nuclear Information System (INIS)

    Whicker, F.W.

    1976-01-01

    This report summarizes project activities during the period May 1, 1975 through July 31, 1976. The major study on the distribution and levels of Pu in major components of the terrestrial ecosystem at Rocky Flats was completed. Supportive studies on the ecology and pathology of small mammals and their role in Pu transport were essentially completed as well. Detailed studies on mule deer food habits, population dynamics, and movements at Rocky Flats are progressing. These studies are designed to measure the potential of mule deer in transporting Pu to uncontrolled areas. Alpha autoradiographic studies designed to measure Pu particle size and distribution and spatial patterns in soil were initiated. Field and greenhouse transport pathways from soil to vegetation are in progress and some early results reported. The status of studies on seasonal kinetics of Cs in a montane lake and stable lead geochemistry in an alpine lake watershed are also reported

  13. High energy particle physics at Purdue. Annual technical progress report, March 1982-March 1983

    International Nuclear Information System (INIS)

    Gaidos, J.A.; Koltick, D.S.; Loeffler, F.J.

    1983-01-01

    Progress is reported in these areas: a study of electron-positron annihilation using the High Resolution Spectrometer at SLAC; proton decay; extensive muon showers; gamma ray astronomy; the DUMAND project; theoretical work on fundamental problems in electromagnetic, weak, strong, and gravitational interactions; chi production by hadrons; p-nucleus interactions; development of the Collider Detector at Fermilab; and study of the observed hadrons as the relativistic bound states of baryons and antibaryons

  14. Geothermal drilling and completion technology development program. Annual progress report, October 1979-September 1980

    Energy Technology Data Exchange (ETDEWEB)

    Varnado, S.G. (ed.)

    1980-11-01

    The progress, status, and results of ongoing research and development (R and D) within the Geothermal Drilling and Completion Technology Development Program are described. The program emphasizes the development of geothermal drilling hardware, drilling fluids, completion technology, and lost circulation control methods. Advanced drilling systems are also under development. The goals of the program are to develop the technology required to reduce well costs by 25% by 1983 and by 50% by 1987.

  15. Environmental Sciences Division annual progress report for period ending September 30, 1992

    Energy Technology Data Exchange (ETDEWEB)

    Van Hook, R. I.; Hildebrand, S. G.; Gehrs, C. W.; Sharples, F. E.; Shriner, D. S.; Stow, S. H.; Cushman, J. H.; Kanciruk, P.

    1993-04-01

    This progress report summarizes the research and development activities conducted in the Environmental Sciences Division of Oak Ridge National Laboratory during fiscal year (FY) 1992, which which extended from October 1, 1991, through September 30, 1992. This report is structured to provide descriptions of current activities and accomplishments in each of the division's major organizational units. Section activities are described in the Earth and Atmospheric sciences, ecosystem studies, Environmental analysis, environmental biotechnology, and division operations.

  16. Fossil Energy Program annual progress report for April 1997 through March 1998

    Energy Technology Data Exchange (ETDEWEB)

    Judkins, R.R.

    1998-07-01

    This report covers progress made on research and development projects that contribute to the advancement of fossil energy technologies, covering the areas of coal, clean coal technology, gas, petroleum, and support to the Strategic Petroleum Reserve (SPR). Papers are arranged under the following topical sections: materials research and development; environmental analysis support; bioprocessing research; fossil fuels supplies modeling and research; and oil and gas production.

  17. Department of Clinical Investigation Annual Research Progress Report, Fiscal Year 1984. Volume 1,

    Science.gov (United States)

    1984-10-01

    Cytoxan (CTX) and aCTH Treatment in Progressive Multiple 128 Sclerosis. (0) C-16-84 The Use of Monoclonal Antibodies to Classify Parapsoriasis . 129 (0) C...84 Status: Ongoing Title: The Use of Monoclonal Antibodies to Classify Parapsoriasis . Start Date 16 Mar 84 Eat Comp Date: Principal Investigator...M.D., LTC, MC Key Words: Charles W. Lewis, M.D., COL, MC Monoclonal antibodies Donald E. Clemons, M.D., COL, MC Parapsoriasis Michael V. Mulvaney, M.D

  18. Fossil Energy Program annual progress report for April 1995 through March 1996

    Energy Technology Data Exchange (ETDEWEB)

    Judkins, R.R.

    1996-06-01

    This report covers progress for research and development projects that contribute to the advancement of various fossil energy technologies. Attention is focused on the following areas: materials research and development; environmental analysis support; bioprocessing research for coal, oil, and natural gas; coal combustion research; fossil fuels supplies modeling and research; and advanced turbine systems. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

  19. Analytical Chemistry Division annual progress report for period ending December 31, 1985

    Energy Technology Data Exchange (ETDEWEB)

    Shultz, W.D.

    1986-05-01

    Progress reports are presented for the four major sections of the division: analytical spectroscopy, radioactive materials laboratories, inorganic chemistry, and organic chemistry. A brief discussion of the division's role in the Laboratory's Environmental Restoration and Facilities Upgrade is given. Information about quality assurance and safety programs is presented, along with a tabulation of analyses rendered. Publications, oral presentations, professional activities, educational programs, and seminars are cited.

  20. Instrumentation and Controls Division annual progress report for period ending September 1, 1973

    International Nuclear Information System (INIS)

    Sadowski, G.S.

    1976-08-01

    Research progress is described under the following topics: (1) pulse counting and analysis; (2) support for the thermonuclear division ORMAK project; (3) miscellaneous electronics development; (4) detectors of ionizing particles and radiation; (5) radiation monitoring; (6) support for the Oak Ridge Electron Linear Accelerator; (7) automatic control and data acquisition; (8) process instrumentation and control; (9) reactor instrumentation and controls; (10) instrumentation for reactor division experiments and test loops; (11) maintenance and service; and (12) ecological science studies

  1. 1992 annual report on low-level radioactive waste management progress

    International Nuclear Information System (INIS)

    1993-11-01

    This report summarizes the progress States and compact regions made during 1992 in establishing new low-level radioactive waste disposal facilities. It also provides summary information on the volume of low-level radioactive waste received for disposal in 1992 by commercially operated low-level radioactive waste disposal facilities. This report is in response to section 7 (b) of the Low-Level Radioactive Waste Policy Act

  2. Environmental Sciences Division annual progress report for period ending September 30, 1992

    International Nuclear Information System (INIS)

    1993-04-01

    This progress report summarizes the research and development activities conducted in the Environmental Sciences Division of Oak Ridge National Laboratory during fiscal year (FY) 1992, which which extended from October 1, 1991, through September 30, 1992. This report is structured to provide descriptions of current activities and accomplishments in each of the division's major organizational units. Section activities are described in the Earth and Atmospheric sciences, ecosystem studies, Environmental analysis, environmental biotechnology, and division operations

  3. Analytical Chemistry Division annual progress report for period ending December 31, 1985

    International Nuclear Information System (INIS)

    Shultz, W.D.

    1986-05-01

    Progress reports are presented for the four major sections of the division: analytical spectroscopy, radioactive materials laboratories, inorganic chemistry, and organic chemistry. A brief discussion of the division's role in the Laboratory's Environmental Restoration and Facilities Upgrade is given. Information about quality assurance and safety programs is presented, along with a tabulation of analyses rendered. Publications, oral presentations, professional activities, educational programs, and seminars are cited

  4. Isotope and nuclear chemistry division. Annual report, FY 1987. Progress report, October 1986-September 1987

    International Nuclear Information System (INIS)

    Barr, D.W.; Heiken, J.H.

    1988-05-01

    This report describes progress in the major research and development programs carried out in FY 1987 by the Isotope and Nuclear Chemistry Division. The report includes articles on radiochemical weapons diagnostics and research and development; other unclassified weapons research; stable and radioactive isotope production and separation; chemical biology and nuclear medicine; element and isotope transport and fixation; actinide and transition metal chemistry; structural chemistry, spectroscopy, and applications; nuclear structure and reactions; irradiation facilities; advanced concepts and technology; and atmospheric chemistry

  5. Cancer and birth defects surveillance system for communities around the Savannah River Site. Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Dunbar, J.B.

    1993-05-01

    This technical report presents the age-adjusted total, and race and sex specific geographic patterns of cancer mortality for South Carolina (SC) counties utilizing the 1953--1987 average annual age-adjusted mortality rates (AAMRs). The mortality information was obtained from the State Cancer Control Map and Data Program produced by the National Cancer Institute , Centers for Disease Control and the American Cancer Society. The AAMRs for selected primary sites are classified as significantly different or not significantly different from the corresponding United States and SC mortality rates. Categories for classification of the rates are determined using 95% confidence intervals. Geographic patterns of significantly high county AAMRs are identified and discussed. Individual county rates are not emphasized. The terminology, mortality rates used throughout this report pertains to the 1953--1987 AAMRS.

  6. NRC high-level radioactive waste program. Annual progress report: Fiscal Year 1996

    International Nuclear Information System (INIS)

    Sagar, B.

    1997-01-01

    This annual status report for fiscal year 1996 documents technical work performed on ten key technical issues (KTI) that are most important to performance of the proposed geologic repository at Yucca Mountain. This report has been prepared jointly by the staff of the Nuclear Regulatory Commission (NRC) Division of Waste Management and the Center for Nuclear Waste Regulatory Analyses. The programmatic aspects of restructuring the NRC repository program in terms of KTIs is discussed and a brief summary of work accomplished is provided. The other ten chapters provide a comprehensive summary of the work in each KTI. Discussions on probability of future volcanic activity and its consequences, impacts of structural deformation and seismicity, the nature of of the near-field environment and its effects on container life and source term, flow and transport including effects of thermal loading, aspects of repository design, estimates of system performance, and activities related to the U.S. Environmental Protection Agency standard are provided

  7. Energy Division annual progress report for period ending September 30, 1981

    International Nuclear Information System (INIS)

    1982-05-01

    This eighth annual report of the Division covers work done during FY 1981 (October 1, 1980, through September 30, 1981). As with these documents in the past, the format follows approximately the organizational structure of the Energy Division. Chapters 2 through 6 summarize the activities of the sections of the Division: Environmental Impact Section, headed by H.E. Zittel; Regional and Urban Studies Section, R.M. Davis; Economic Analysis Section, R.B. Shelton; Data and Analysis Section, A.S. Loebl; and Efficiency and Renewables Research Section, J.W. Michel. In addition, work on a variety of projects which cut across section lines is reported in Chapter 7, Integrated Programs. These activities are under the supervision of T.J. Wilbanks, Associate Director for the Division. Separate abstracts are included for individual projects

  8. Energy Division annual progress report for period ending September 30, 1981

    Energy Technology Data Exchange (ETDEWEB)

    1982-05-01

    This eighth annual report of the Division covers work done during FY 1981 (October 1, 1980, through September 30, 1981). As with these documents in the past, the format follows approximately the organizational structure of the Energy Division. Chapters 2 through 6 summarize the activities of the sections of the Division: Environmental Impact Section, headed by H.E. Zittel; Regional and Urban Studies Section, R.M. Davis; Economic Analysis Section, R.B. Shelton; Data and Analysis Section, A.S. Loebl; and Efficiency and Renewables Research Section, J.W. Michel. In addition, work on a variety of projects which cut across section lines is reported in Chapter 7, Integrated Programs. These activities are under the supervision of T.J. Wilbanks, Associate Director for the Division. Separate abstracts are included for individual projects.

  9. Nuclear structure theory. Annual technical progress report, October 1, 1977--September 30, 1978

    International Nuclear Information System (INIS)

    French, J.B.; Koltun, D.S.

    1978-01-01

    Progress during the past year in the following areas of nuclear structure and reaction theory is summarized: statistical spectroscopy, including random matrix methods, with applications to fluctuations in spectra and in strength distributions, and to problems of erogodicity; group symmetries in spectral distribution theory; effective interactions; statistical reaction theory, applied to ''deep inelastic'' collisions of heavy ions, and to pion absorption by nuclei; meson scattering and absorption by nuclei, including general scattering theory with absorption, multiple scattering theory and its reactive content, models for absorption, theory of the absorption operator (πNN vertex), theory of πN scattering. A list of publications is included

  10. Nuclear structure theory. Annual technical progress report, October 1, 1976--September 30, 1977

    International Nuclear Information System (INIS)

    French, J.B.; Koltun, D.S.

    1977-01-01

    This report summarizes progress during the past year in the following areas of nuclear structure and reaction theory: (1) statistical spectroscopy, including giant resonances for beta and electromagnetic excitation and sum rules (including inverse-energy-weighted sum rules), statistical methods of truncating shell model spaces and renormalization of operators, study of state labelling and ''chains'' of groups, evaluation of fluctuation measures, technical aspects of operator averaging; (2) meson interactions with nuclei, including scattering and absorption of mesons by nuclei (general methods), models for absorption, single- and double-charge exchange of pions, role of rho mesons

  11. Spectroscopy, modeling and computation of metal chelate solubility in supercritical CO2. 1998 annual progress report

    International Nuclear Information System (INIS)

    Brennecke, J.F.; Chateauneuf, J.E.; Stadtherr, M.A.

    1998-01-01

    'This report summarizes work after 1 year and 8 months (9/15/96-5/14/98) of a 3 year project. Thus far, progress has been made in: (1) the measurement of the solubility of metal chelates in SC CO 2 with and without added cosolvents, (2) the spectroscopic determination of preferential solvation of metal chelates by cosolvents in SC CO 2 solutions, and (3) the development of a totally reliable computational technique for phase equilibrium computations. An important factor in the removal of metals from solid matrices with CO 2 /chelate mixtures is the equilibrium solubility of the metal chelate complex in the CO 2 .'

  12. Geothermal Energy R&D Program Annual Progress Report Fiscal Year 1993

    Energy Technology Data Exchange (ETDEWEB)

    None

    1994-04-01

    In this report, the DOE Geothermal Program activities were split between Core Research and Industrial Development. The technical areas covered are: Exploration Technology, Drilling Technology, Reservoir Technology (including Hot Dry Rock Research and The Geyser Cooperation), and Conversion Technology (power plants, materials, and direct use/direct heat). Work to design the Lake County effluent pipeline to help recharge The Geysers shows up here for the first time. This Progress Report is another of the documents that are reasonable starting points in understanding many of the details of the DOE Geothermal Program. (DJE 2005)

  13. Annual progress report on nuclear data 1983 of the Central Bureau for Nuclear Measurements, Geel (Belgium)

    International Nuclear Information System (INIS)

    1984-05-01

    In this progress report of the Central Bureau for Nuclear Measurements at Geel (Belgium) researches related to neutron data and to non-neutron nuclear data are gathered. Neutron data are essentially related to cross-section measurements: for instance, concerning actinides, structural materials as Cr and Fe, fission products. Some studies are classified as concerning standard neutron data. Underlying physics is no forgotten neither than equipment (linear accelerator). Non-neutron nuclear data is concerned essentially with decay studies. Some compilations and evaluations are also given. Improvement of measurement and source preparation techniques is a part of this section

  14. Nuclear structure theory. Annual technical progress report, October 1, 1978-September 30, 1979

    International Nuclear Information System (INIS)

    French, J.B.; Koltun, D.S.

    1979-01-01

    This report summarizes progress during the past year in the following areas of nuclear structure and reaction theory: Statistical spectroscopy, including: Random matrix methods, with applications to fluctuations in spectra and in strength distributions, and to problems of ergodicity; Group symmetries in spectral-distribution theory; Electromagnetic and β transitions. Meson scattering and absorption by nuclei, including: general scattering theory with absorption, multiple scattering theory and its reactive content, statistical theory of absorption, theory of the absorption operator (πNN vertex), theory of πN scattering. A list of publications is included

  15. Letterman Army Institute of Research Annual Research Progress Report, FY 1981.

    Science.gov (United States)

    1981-10-01

    CONITOL symbol.: RESEARCH AND TECHNOLOGY WORK UNIT SUMMARY DAOG 6202 81 10 01 DD-DH&a(AR)6O6 O.-DATE PR V SUMRV 4. KID OF SUMMARY L SUMMARY SCTV W SITV* V...loss of stability is seen in the AsP at room temperature. Similar studies were being planned to reevaluate the solution stability of DHA , but were...cancelled when the company holding the patent on using DHA terminated the manufacture of blood bags. Final studies are in progress to obtain the optimal

  16. Fundamental studies of elastomers. Annual progress report, June 15, 1985-March 21, 1986

    International Nuclear Information System (INIS)

    Eichinger, B.E.

    1986-01-01

    The progress report for the first year of this grant described computer simulations on random networks, shape distributions, synthesis of chelation networks, and coordination polymers. Work has continued in all four of these areas in the past year. Highlighted here is the work that we have been doing on computer simulations of random cross-linking, wherein radiation damage is a very important feature of the chemical reactions that occur. Furthermore, we have made a coordination compound which looks quite encouraging at the present time. Our efforts on chelation networks are proceeding and we are developing very promising methods for creating the polymers that we need for these studies

  17. Department of Clinical Investigation Annual Research Progress Report, Fiscal Year 1985. Volume 1,

    Science.gov (United States)

    1985-10-01

    Cytoxan (CTX) and aCTH Treatment in Progressive Multiple 84 Sclerosis. (T) C-16-84 The Use of Monoclonal Antibodies to Classify Parapsoriasis . 85 (0) C-18...Monoclonal Antibodies to Classify Parapsoriasis . * Start Date 16 Mar 84 Est Comp Date: Principal Investigator Facility James H. Keeling, M.D., MAJ, MC...M.D., COL, MC Monoclonal antibodies Donald E. Clemons, M.D., COL, MC Parapsoriasis Michael V. Mulvaney, M.D., CPT, MC Neil F. Haddock, M. D., CPT, MC

  18. 1996 annual report on low-level radioactive waste management progress. Report to Congress

    International Nuclear Information System (INIS)

    1997-11-01

    This report is prepared in response to the Low-Level Radioactive Waste Policy Act (the Act), Public Law 96-573, 1980, as amended by the Low-Level Radioactive Waste Policy Amendments Act of 1985, Public Law 99-240. The report summarizes the activities during calendar year 1996 related to the establishment of new disposal facilities for commercially-generated low-level radioactive waste. The report emphasizes significant issues and events that have affected progress in developing new disposal facilities, and also includes an introduction that provides background information and perspective on US policy for low-level radioactive waste disposal

  19. Progress in application of hybrid numerical simulation methods to magnetic confinement systems. Annual report

    International Nuclear Information System (INIS)

    Morse, R.L.

    1979-06-01

    Hybrid codes have been developed to simulate high density, high β confined plasmas. The major areas of application have been end plugging and heating of linear confinement systems. In particular, significant progress has been made in understanding the role of line and recombination radiation in recent experiments which showed large increases in energy confinement times from the use of solid end plugs. Another accomplishment is the conception and theoretical analysis of an efficient, low frequency, axial heating method which we believe could significantly increase the attractiveness of linear systems as reactors

  20. FY2016 Advanced Batteries R&D Annual Progress Report - Part 3 of 5

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2017-08-31

    The Advanced Batteries research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for projects focusing on batteries for plug-in electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush. This report describes the progress made on the research and development projects funded by the Battery subprogram in 2016. This section covers the summaries of the Applied Batteries Research for Transportation Projects part 2.

  1. FY 2014 Annual Progress Report - Advanced Combustion Engine Research and Development (Book)

    Energy Technology Data Exchange (ETDEWEB)

    2014-11-01

    In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

  2. FY2016 Advanced Batteries R&D Annual Progress Report - Part 4 of 5

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2017-08-31

    The Advanced Batteries research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for projects focusing on batteries for plug-in electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush. This report describes the progress made on the research and development projects funded by the Battery subprogram in 2016. This section covers Advanced Battery Materials Research (BMR) part 1.

  3. FY2016 Advanced Batteries R&D Annual Progress Report - Part 2 of 5

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2017-08-31

    The Advanced Batteries research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for projects focusing on batteries for plug-in electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush. This report describes the progress made on the research and development projects funded by the Battery subprogram in 2016. This section covers the summaries of the Applied Batteries Research for Transportation Projects part 1.

  4. 2011 Annual Progress Report: DOE Hydrogen and Fuel Cells Program (Book)

    Energy Technology Data Exchange (ETDEWEB)

    2011-11-01

    In the past year, the DOE Hydrogen and Fuel Cells Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

  5. High energy particle physics at Purdue. Annual technical progress report, March 1983-March 1984

    International Nuclear Information System (INIS)

    Gaidos, J.A.; Koltick, D.S.; Loeffler, F.J.

    1984-01-01

    Progress is reported in these areas: a study of electron-positron annihilation using the High Resolution Spectrometer; experimental study of proton decay; gamma ray astrophysics; the DUMAND project; fundamental problems in the theory of gravitational, electromagnetic, weak, and strong interactions; chi production by hadrons; study of collective phenomena; search for the onset of collective phenonmena; work on the Collider Detector at Fermilab; search for a deconfined quark-gluon phase of strongly interacting matter at the FNAL proton-antiproton collider; and development of an electrodeless drift chamber

  6. High energy particle physics at Purdue. Annual progress report, March 1981-1982

    International Nuclear Information System (INIS)

    Gaidos, J.A.; Koltick, D.S.; Loeffler, F.J.; McIlwain, R.L.; Miller, D.H.; Palfrey, T.R.; Shibata, E.I.; Willmann, R.B.

    1982-01-01

    Progress is reported in these areas: study of electron positron annihilation using the High Resolution Spectrometer at PEP; experimental study of proton decay; a study of rare processes in meson spectroscopy utilizing the SLAC Hybrid Bubble Chamber System; theory of fundamental problems of gravitational, electromagnetic, weak, and strong interactions; experimental study of chi production by hadrons; p-nucleus interactions; development of the Collider Detector at Fermilab; anitneutrino physics and low energy neutrino physics; and the study of the observed hadrons as the relativistic bound states of baryons and antibaryons

  7. Vacuum-ultraviolet electronic properties of liquids. Annual progress report, November 1, 1980-January 31, 1982

    International Nuclear Information System (INIS)

    Painter, L.R.

    1980-01-01

    Progress is reviewed on the following research areas: (1) electron mean free paths in liquid formamide; (2) yields and mean free paths of photoelectrons from liquid hexamethylphosphorictricamide; (3) evidence for collective electronic oscillations in electron bombarded liquid siloxane; (4) a new technique for measuring the reflectance of high vapor pressure liquids; (5) construction of soft x-ray monochromator; (6) electronic properties of benzene and methyl benzene derivatives; (7) optical and dielectric functions of squalane and squalene; and (8) photoemission of squalene and tetraglyme. Separate abstracts were prepared for the two papers included, and are entered in the data base separately

  8. FY2016 Advanced Batteries R&D Annual Progress Report - Part 5 of 5

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2017-08-31

    The Advanced Batteries research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for projects focusing on batteries for plug-in electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush. This report describes the progress made on the research and development projects funded by the Battery subprogram in 2016. This section cover Advanced Battery Materials Research (BMR) part 2, Battery500 Innovation Centers project summaries, and appendices.

  9. Ultrascale Visualization Climate Data Analysis Tools (UV-CDAT): Semi-Annual Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Williams, D N

    2012-02-29

    This report summarizes work carried out by the Ultrascale Visualization Climate Data Analysis Tools (UV-CDAT) Team for the period of July 1, 2011 through December 31, 2011. It discusses highlights, overall progress, period goals, and collaborations and lists papers and presentations. The UV-CDAT team is positioned to address the following high-level visualization requirements: (1) Alternative parallel streaming statistics and analysis pipelines - Data parallelism, Task parallelism, Visualization parallelism; (2) Optimized parallel input/output (I/O); (3) Remote interactive execution; (4) Advanced intercomparison visualization; (5) Data provenance processing and capture; and (6) Interfaces for scientists - Workflow data analysis and visualization construction tools, Visualization interfaces.

  10. Controlled thermonuclear materials technology program. Annual progress report for period ending June 30, 1975

    International Nuclear Information System (INIS)

    Scott, J.L.

    1975-10-01

    Detailed descriptions are given of research progress in the following areas: (1) microstructure of irradiated 316 stainless steel containing high helium concentrations, (2) temperature and fluence limitations for a type 316 stainless steel CTR first wall, (3) swelling and microstructural changes in irradiated vanadium alloys, (4) mechanical properties of irradiated V-20 wt percent Ti, (5) radiation damage calculations, (6) evaluation of irradiation facilities for CTR materials development, (7) surface studies, compatibility studies, (8) magnet development, (9) EPR design support, and (10) the influence of structural materials on fusion-reactor blanket response. (MOW)

  11. Annual report on reactor safety research projects sponsored by the Ministry for Research and Technology of the Federal Republic of Germany. Reporting period 1993. Progress report

    International Nuclear Information System (INIS)

    1994-10-01

    The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, by order of the BMFT, informs continuously of the status of such investigations by means of semi-annual and annual publication of progress reports within the series GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about objectives, the work performed, the results, the next steps of the work etc. The individual reports are prepared in a standard form by the contractors themselves as a documentation of their progress in work and published by the Forschungsbetreuung at the GRS, (FB) (Research Coordination Department), within the framework of general information of progress in reactor safety research. The individual reports are classified according to the same classification system as applied in the nuclear index of the CEC (Commission of the European Communities) and the OECD (Organization for Economic Cooperation and Development). The reports are arranged in sequence of their project numbers. (orig./HP)

  12. Joint inversion of geophysical data for site characterization and restoration monitoring. 1998 annual progress report

    International Nuclear Information System (INIS)

    Berge, P.A.; Berryman, J.G.; Roberts, J.J.; Wildenschild, D.

    1998-01-01

    'The purpose of this project is to develop a computer code for joint inversion of seismic and electrical data, to improve underground imaging for site characterization and remediation monitoring. The computer code developed in this project will invert geophysical data to obtain direct estimates of porosity and saturation underground, rather than inverting for seismic velocity and electrical resistivity or other geophysical properties. This is intended to be a significant improvement in the state-of-the-art of underground imaging, since interpretation of data collected at a contaminated site would become much less subjective. Potential users include DOE scientists and engineers responsible for characterizing contaminated sites and monitoring remediation of contaminated sites. In this three-year project, the authors use a multi-phase approach consisting of theoretical and numerical code development, laboratory investigations, testing on available laboratory and borehole geophysics data sets, and a controlled field experiment, to develop practical tools for joint electrical and seismic data interpretation. This report summarizes work after about 1.7 years of a 3-year project. Progress on laboratory measurements is described first, followed by progress on developing algorithms for the inversion code to relate geophysical data to porosity and saturation.'

  13. Environmental Sciences Division annual progress report for period ending September 30, 1991

    Energy Technology Data Exchange (ETDEWEB)

    1992-04-01

    This progress report summarizes the research and development activities conducted in the Environmental Sciences Division of Oak Ridge National Laboratory during the period October 1, 1990, through September 30, 1991. The report is structured to provide descriptions of current activities and accomplishments in each of the division's major organizational units. Following the sections describing the organizational units is a section devoted to lists of information necessary to convey the scope of the work in the division. The Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) conducts environmental research and analyses associated with both energy technology development and the interactions between people and the environment. The division engages in basic and applied research for a diverse list of sponsors. While the US Department of Energy (DOE) is the primary sponsor ESD staff also perform research for other federal agencies, state agencies, and private industry. The division works collaboratively with federal agencies, universities, and private organizations in achieving its research objectives and hosts a large number of visiting investigators from these organizations. Given the diverse interdisciplinary specialization of its staff, ESD provides technical expertise on complex environmental problems and renders technical leadership for major environmental issues of national and local concern. This progress report highlights many of ESD's accomplishment in these and other areas in FY 1991.

  14. Environmental Sciences Division annual progress report for period ending September 30, 1991

    Energy Technology Data Exchange (ETDEWEB)

    1992-04-01

    This progress report summarizes the research and development activities conducted in the Environmental Sciences Division of Oak Ridge National Laboratory during the period October 1, 1990, through September 30, 1991. The report is structured to provide descriptions of current activities and accomplishments in each of the division`s major organizational units. Following the sections describing the organizational units is a section devoted to lists of information necessary to convey the scope of the work in the division. The Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) conducts environmental research and analyses associated with both energy technology development and the interactions between people and the environment. The division engages in basic and applied research for a diverse list of sponsors. While the US Department of Energy (DOE) is the primary sponsor ESD staff also perform research for other federal agencies, state agencies, and private industry. The division works collaboratively with federal agencies, universities, and private organizations in achieving its research objectives and hosts a large number of visiting investigators from these organizations. Given the diverse interdisciplinary specialization of its staff, ESD provides technical expertise on complex environmental problems and renders technical leadership for major environmental issues of national and local concern. This progress report highlights many of ESD`s accomplishment in these and other areas in FY 1991.

  15. Experimental and theoretical high energy physics research. Annual progress report, September 1, 1991--September 31, 1992

    Energy Technology Data Exchange (ETDEWEB)

    1992-10-01

    Progress in the various components of the UCLA High-Energy Physics Research program is summarized, including some representative figures and lists of resulting presentations and published papers. Principal efforts were directed at the following: (I) UCLA hadronization model, PEP4/9 e{sup +}e{sup {minus}} analysis, {bar P} decay; (II) ICARUS and astroparticle physics (physics goals, technical progress on electronics, data acquisition, and detector performance, long baseline neutrino beam from CERN to the Gran Sasso and ICARUS, future ICARUS program, and WIMP experiment with xenon), B physics with hadron beams and colliders, high-energy collider physics, and the {phi} factory project; (III) theoretical high-energy physics; (IV) H dibaryon search, search for K{sub L}{sup 0} {yields} {pi}{sup 0}{gamma}{gamma} and {pi}{sup 0}{nu}{bar {nu}}, and detector design and construction for the FNAL-KTeV project; (V) UCLA participation in the experiment CDF at Fermilab; and (VI) VLPC/scintillating fiber R & D.

  16. Effects of aqueous effluents from in situ fossil fuel processing technologies on aquatic systems. Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Bergman, H.L.; Anderson, A.D.

    1977-12-01

    This is the first annual report issued under a project to evaluate the effects of aqueous effluents from in-situ fossil fuel processing technologies on aquatic biota. Briefly, the goals of the project are to: evaluate the toxicity of process water effluents on aquatic biota; recommend maximum exposure concentrations for process water constituents; and assist DOE in using project data and recommendations to design control technologies and to assess environmental impacts. The project objectives for Year 1 were pursued through the following five tasks: a literature review on process water constituents; toxicity studies on the effect of process waters and six process water constituents on aquatic biota; degradation rate studies on four to six process water constituents; bioaccumulation studies on four to six process water constituents; and recommendations on maximum exposure concentrations for process water constituents based on data from the project and from the literature. Progress toward completion of these goals is presented.

  17. Testosterone deficiency induced by progressive stages of diabetes mellitus impairs glucose metabolism and favors glycogenesis in mature rat Sertoli cells.

    Science.gov (United States)

    Rato, Luís; Alves, Marco G; Duarte, Ana I; Santos, Maria S; Moreira, Paula I; Cavaco, José E; Oliveira, Pedro F

    2015-09-01

    The incidence of type 2 diabetes mellitus and its prodromal stage, pre-diabetes, is rapidly increasing among young men, leading to disturbances in testosterone synthesis. However, the impact of testosterone deficiency induced by these progressive stages of diabetes on the metabolic behavior of Sertoli cells remains unknown. We evaluated the effects of testosterone deficiency associated with pre-diabetes and type 2 diabetes on Sertoli cells metabolism, by measuring (1) the expression and/or activities of glycolysis and glycogen metabolism-related proteins and (2) the metabolite secretion/consumption in Sertoli cells obtained from rat models of different development stages of the disease, to unveil the mechanisms by which testosterone deregulation may affect spermatogenesis. Glucose and pyruvate uptake were decreased in cells exposed to the testosterone concentration found in pre-diabetic rats (600nM), whereas the decreased testosterone concentrations found in type 2 diabetic rats (7nM) reversed this profile. Lactate production was not altered, although the expression and/or activity of lactate dehydrogenase and monocarboxylate transporter 4 were affected by progressive testosterone-deficiency. Sertoli cells exposed to type 2 diabetic conditions exhibited intracellular glycogen accumulation. These results illustrate that gradually reduced levels of testosterone, induced by progressive stages of diabetes mellitus, favor a metabolic reprogramming toward glycogen synthesis. Our data highlights a pivotal role for testosterone in the regulation of spermatogenesis metabolic support by Sertoli cells, particularly in individuals suffering from metabolic diseases. Such alterations may be in the basis of male subfertility/infertility associated with the progression of diabetes mellitus. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. National Institute for Rocket Propulsion Systems 2012 Annual Report: A Year of Progress and Challenge

    Science.gov (United States)

    Thomas, L. Dale; Doreswamy, Rajiv; Fry, Emma Kiele

    2013-01-01

    The National Institute for Rocket Propulsion Systems (NIRPS) maintains and advances U.S. leadership in all aspects of rocket propulsion for defense, civil, and commercial uses. The Institute's creation is in response to widely acknowledged concerns about the U.S. rocket propulsion base dating back more than a decade. U.S. leadership in rocket and missile propulsion is threatened by long-term industry downsizing, a shortage of new solid and liquid propulsion programs, limited ability to attract and retain fresh talent, and discretionary federal budget pressures. Numerous trade and independent studies cite erosion of this capability as a threat to national security and the U.S. economy resulting in a loss of global competitiveness for the U.S. propulsion industry. This report covers the period between May 2011 and December 2012, which includes the creation and transition to operations of NIRPS. All subsequent reports will be annual. The year 2012 has been an eventful one for NIRPS. In its first full year, the new team overcame many obstacles and explored opportunities to ensure the institute has a firm foundation for the future. NIRPS is now an active organization making contributions to the development, sustainment, and strategy of the rocket propulsion industry in the United States. This report describes the actions taken by the NIRPS team to determine the strategy, organizational structure, and goals of the Institute. It also highlights key accomplishments, collaborations with other organizations, and the strategic framework for the Institute.

  19. Making good progress. SwissEnergy 2nd annual report 2002/03

    International Nuclear Information System (INIS)

    2003-01-01

    The second annual report for the Swiss Federal Office of Energy's 'SwissEnergy' programme presents the activities carried out and the results achieved within the framework of the programme, which aims to help implement Switzerland's climate change policy. SwissEnergy is a national programme in which the government, the cantons, local authorities, the private sector, consumer and environmental organisations, as well as public and private-sector agencies work together as partners. In the first part of the report, strategies - including increasing energy efficiency and the promotion of the use of renewable forms of energy - are described, as are the measures taken, which focus on voluntary efforts by trade and industry. Also, the programme's organisation in four sectors - public sector and buildings, trade and industry, mobility and renewable energy - are described. The second part of the report is dedicated to activities carried out in 2002/2003 and describes economic and policy developments, project management activities and those carried out in the four sectors. The third section discusses the impact of the programme's activities in 2002 on Switzerland's energy consumption and its contribution to the implementation of Switzerland's climate policy. The evaluation procedures used to establish the impact and their accuracy are discussed. The report also discusses the programme's impact on investment and employment in Switzerland

  20. Terrestrial photovoltaic power systems with sunlight concentration. Annual progress report, January 1, 1975--December 31, 1975

    Energy Technology Data Exchange (ETDEWEB)

    Backus, C.E.

    1976-01-31

    This annual report is for the second year of a program to investigate the characteristics of the components and the total system using sunlight concentrated onto solar cells. The second year was primarily to experimentally investigate the conclusions of the first year of analytical studies. Cells have been fabricated that are designed for different intensities. Typically the efficiency of a cell will increase from its 11 percent at AM1 peak to efficiency at the designed concentration level and return to its initial efficiency at about 3 times its designed concentration level. The developed cells have been tested under high intensity simulators and in concentrated sunlight and have shown to have the predicted response. The experimental testing of passive cooling limitations for cooling cells with just finned arrangements in the back of the cell has been completed in the controlled environment of a wind tunnel. These experiments have confirmed the heat transfer coefficients that had been used in the analytical studies. Testing was done to collect heat transfer coefficients for actual wind conditions and these data show good agreement with the controlled wind tunnel data. Four photovoltaic/concentrator system experiments have been started with CR of about 3, 10, 25, and 100. System analysis has indicated that photovoltaic concentration systems may be attractive in low solar irradiation areas such as Cleveland.

  1. Kootenai River Fisheries Investigation : Stock Status of Burbot : Project Progress Report 2008 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Paragamian, Valughn L.; Laude Dorothy C.

    2008-12-26

    Objectives of this investigation were to (1) monitor the population status and recruitment of burbot Lota lota in the Kootenai River, Idaho and British Columbia, Canada during the winter of 2006-2007; (2) evaluate the selective withdrawal system in place at Libby Dam to maintain the river temperature near Bonners Ferry between 1-4 C (November-December) to improve burbot migration and spawning activity; and (3) determine if a hatching success of 10% of eyed burbot embryos could be achieved through extensive rearing and produce fingerlings averaging 9.8 cm in six months. Water temperature did not fall below the upper limit (4 C) until mid-January but was usually maintained between 1-4 C January through February and was acceptable. Snowpack was characterized by a 101% of normal January runoff forecast. Adult burbot were sampled with hoop nets and slat traps. Only three burbot were captured in hoop nets, all at Ambush Rock (rkm 244.5). No burbot were caught in either slat traps or juvenile sampling gear, indicating the population is nearly extirpated. Burbot catch per unit effort in hoop nets was 0.003 fish/net d. Extensive rearing was moved to a smaller private pond and will be reported in the 2008-2009 annual report.

  2. Savannah River Ecology Laboratory. Annual technical progress report of ecological research

    International Nuclear Information System (INIS)

    Smith, M.H.

    1996-01-01

    The Savannah River Ecology Laboratory (SREL) is a research unit of the University of Georgia (UGA). The overall mission of the Laboratory is to acquire and communicate knowledge of ecological processes and principles. SREL conducts basic and applied ecological research, as well as education and outreach programs, under a contract with the U.S. Department of Energy (DOE) at the Savannah River Site (SRS) near Aiken, South Carolina. Significant accomplishments were made during the past year in the areas of research, education and service. The Laboratory's research mission was fulfilled with the publication of two books and 143 journal articles and book chapters by faculty, technical and students, and visiting scientists. An additional three books and about 80 journal articles currently are in press. Faculty, technician and students presented 193 lectures, scientific presentations, and posters to colleges and universities, including minority institutions. Dr. J Vaun McArthur organized and conducted the Third Annual SREL Symposium on the Environment: New Concepts in Strewn Ecology: An Integrative Approach. Dr. Michael Newman conducted a 5-day course titled Quantitative Methods in Ecotoxicology, and Dr. Brian Teppen of The Advanced Analytical Center for Environmental Sciences (AACES) taught a 3-day short course titled Introduction to Molecular Modeling of Environmental Systems. Dr. I. Lehr Brisbin co-hosted a meeting of the Crocodile Special Interest Group. Dr. Rebecca Sharitz attended four symposia in Japan during May and June 1996 and conducted meetings of the Executive Committee and Board of the International Association for Ecology (ENTECOL)

  3. Savannah River Ecology Laboratory. Annual technical progress report of ecological research

    Energy Technology Data Exchange (ETDEWEB)

    Smith, M.H.

    1996-07-31

    The Savannah River Ecology Laboratory (SREL) is a research unit of the University of Georgia (UGA). The overall mission of the Laboratory is to acquire and communicate knowledge of ecological processes and principles. SREL conducts basic and applied ecological research, as well as education and outreach programs, under a contract with the U.S. Department of Energy (DOE) at the Savannah River Site (SRS) near Aiken, South Carolina. Significant accomplishments were made during the past year in the areas of research, education and service. The Laboratory`s research mission was fulfilled with the publication of two books and 143 journal articles and book chapters by faculty, technical and students, and visiting scientists. An additional three books and about 80 journal articles currently are in press. Faculty, technician and students presented 193 lectures, scientific presentations, and posters to colleges and universities, including minority institutions. Dr. J Vaun McArthur organized and conducted the Third Annual SREL Symposium on the Environment: New Concepts in Strewn Ecology: An Integrative Approach. Dr. Michael Newman conducted a 5-day course titled Quantitative Methods in Ecotoxicology, and Dr. Brian Teppen of The Advanced Analytical Center for Environmental Sciences (AACES) taught a 3-day short course titled Introduction to Molecular Modeling of Environmental Systems. Dr. I. Lehr Brisbin co-hosted a meeting of the Crocodile Special Interest Group. Dr. Rebecca Sharitz attended four symposia in Japan during May and June 1996 and conducted meetings of the Executive Committee and Board of the International Association for Ecology (ENTECOL).

  4. Research in radiobiology: Annual report of work in progress in the internal irradiation program

    International Nuclear Information System (INIS)

    Miller, S.C.; Buster, D.S.

    1987-01-01

    In the early 1950's the Atomic Energy Commission established at the University of Utah a large, long-term study designed to investigate the toxicity of internally deposited radionuclides in beagles. The first animals were injected on December 1, 1952 and thus began an odyssey unusual in modern science both for its duration and continued scientific interest and relevance. The original dogs were injected with 239 Pu and 226 Ra. Later, studies were initiated with 241 Am, 249 Cf, 252 Cf, 253 Es, 224 Ra, 228 Ra, 90 Sr, and 228 Th. These studies were unique and have and will continue to contribute valuable scientific information on the behavior and effects of these substances in biological systems. We feel that the data collected from these studies will be useful for many decades to come as we ask more demanding questions relative to radionuclides and environmental, biological and health issues. While this publication will be the last of our series Research in Radiobiology, the lifespan carcinogenesis studies are continuing under a collaborative arrangement with the I.T.R.I. Beginning in 1988, the colony status tables of dogs in the Utah studies and reports of research by the Radiobiology faculty will be included in the annual I.T.R.I. report. Under our new collaborative arrangements with the I.T.R.I. for the conduct of the lifespan carcinogenesis studies, we expect a continued high level of scientific productivity from our faculty

  5. Instrumentation and process control for fossil demonstration plants. Annual technical progress report, October 1976--September 1977

    Energy Technology Data Exchange (ETDEWEB)

    LeSage, L. G.; O' Fallon, N. M.

    1977-10-01

    Progress on Instrumentation and Process Control for Fossil Demonstration Plants (FDP) is reported. Work has been performed on updating the study of the state-of-the-art of instrumentation for FDP, development of mass-flow and other on-line instruments for FDP, process control analysis for FDP, and organization of a symposium on instrumentation and control for FDP. A Solids/Gas Flow Test Facility (S/GFTF) under construction for instrument development, testing, evaluation, and calibration is described. The development work for several mass-flow and other on-line instruments is described: acoustic flowmeter, capacitive density flowmeter, neutron activation flowmeter, gamma ray correlation flowmeter, optical flowmeter, composition analysis system, and capacitive liquid interface level meter.

  6. Annual progress report of the Condensed Matter Physics and Chemistry Department. 1 January - 31 December 2000

    Energy Technology Data Exchange (ETDEWEB)

    Lebech, B. [ed.

    2001-03-01

    The Condensed Matter Physics and Chemistry Department is concerned with both fundamental and applied research into the physical and chemical properties of materials. The principal activities in the year 2000 are presented in this progress report. The research in physics is concentrated on neutron and x-ray scattering measurements and the problems studied include two- and three-dimensional structures, magnetic ordering and spin dynamics, superconductivity, phase transitions and nano-scale structures. The research in chemistry includes chemical synthesis and physico-chemical investigation of small molecules and polymers, with emphasis on polymers with new optical properties, block copolymers, surface-modified polymers, and supramolecular structures. Theoretical work related to these problems is undertaken, including Monte Carlo simulations, computer simulation of molecules and polymers and methods of data analysis. (au)

  7. Annual progress report of the Condensed Matter Physics and Chemistry Department 1 January - 31 December 1998

    Energy Technology Data Exchange (ETDEWEB)

    Bechgaard, K.; Clausen, K.N.; Feidenhans`l, R.; Johannsen, I. [eds.

    1999-04-01

    The Condensed Matter Physics and Chemistry Department is concerned with both fundamental and applied research into the physical properties of materials. The principal activities in the year 1998 are presented in this progress report. The research in physics is concentrated on neutron and x-ray scattering measurements and the problems studied include two- and three-dimensional structures, magnetic ordering and spin dynamics, superconductivity, phase transitions and nano-scale structures. The research in chemistry includes chemical synthesis and physico-chemical investigation of small molecules and polymers, with emphasis on polymers with new optical properties, block copolymers, surface-modified polymers, and supramolecular structures. Theoretical work related to these problems is undertaken, including Monte Carlo simulations, computer simulation of molecules and polymers and methods of data analysis. (au) 2 tabs., 142 ills., 169 refs.

  8. Environmental Sciences Division annual progress report for period ending September 30, 1993

    Energy Technology Data Exchange (ETDEWEB)

    1994-05-01

    This progress report summarizes the research and development activities conducted in the Environmental Sciences Division (ESD) of Oak Ridge National Laboratory during fiscal year (FY) 1993, which extended from October 1, 1992, through September 30, 1993. The report is structured to provide descriptions of current activities and accomplishments in each of the division`s major organizational units. Following the sections describing the organizational units are sections highlighting ESD Scientific, Technical, and Administrative Achievement awards and listing information necessary to convey the scope of the work in the division. An organizational chart of staff and long-term guests who were in ESD and the end of FY 1993 is located in the final section of the report.

  9. Cladding and structural materials semi-annual progress report, January 1975--July 1975

    International Nuclear Information System (INIS)

    Claudson, T.T.

    1975-10-01

    Theoretical and experimental programs are in progress to determine the effects of fast neutron radiation on the mechanical properties and swelling of 3C4 and 316SS cladding and duct materials. Detailed specimen characterization and detailed test conditions are required in order to provide the 2 to 5 percent accuracy of results at 1γ. Preliminary swelling tests show that swelling in stressed assemblies is much larger than in unstressed structural components. Correlation of swelling data from high exposure cladding (11.4 at. percent burnup) agrees with previous data and with the current design equation for 20 percent CW 316 stainless steel. Improved techniques for TEM specimen preparation are described along with recent results on crack propagation. Initial results are given for the effects of aging on Inconel 718 base and weld materials. Compilations of these design values of materials properties have been issued in the form of the Nuclear Systems Materials Handbook

  10. Annual progress report of the Department of Solid State Physics 1 January - 31 December 1995

    Energy Technology Data Exchange (ETDEWEB)

    Joergensen, M.; Bechgaard, K.; Clausen, K.N.; Feidenhans`l, R.; Johannsen, I. [eds.

    1996-01-01

    Research in the department is concerned with `Materials with Distinct Physical and Chemical Properties`. The principal activities of the department in the period from 1 January to 31 December, 1995, are presented in this Progress Report. Neutron and x-ray diffraction techniques are used to study a wide variety of problems in condensed matter physics and include: two- and three-dimensional structures, magnetic ordering, heavy fermions, high T{sub c} superconductivity, phase transitions in model systems, precipitation phenomena, and nano-scale structures in various materials. The research in chemistry includes chemical synthesis and physico-chemical investigation of small molecules and polymers, with emphasis on polymers with new optical properties, block copolymers, surface modified polymers, and supramolecular structures. Related to these problems there is work going on in theory, Monte Carlo simulations, computer simulation of molecules and polymers and methods of data analysis. (au) 5 tabs., 135 ills., 163 refs.

  11. Nuclear powered satellite studies. Annual progress report, July 1, 1976--June 30, 1977

    International Nuclear Information System (INIS)

    Kaplan, M.H.

    1977-06-01

    Progress achieved during the period July 1, 1976 to June 30, 1977 is reported. Discussions of several pertinent aspects are included, e.g., schedule, personnel, technology developments, and plans. The reporting period is the first year of activities of a project which is designed to provide continuing support to the Nuclear Research and Applications Division of ERDA. Thus, a significant effort has been made to establish appropriate staff positions and liaison ties with government and industry. Technology developments were achieved and communicated to the scientific community via publications and presentations. Project personnel also participated in design reviews and provided support to ERDA on a real-time basis. The report is intended to summarize activities over the past year and provides a basis for continued project support by ERDA

  12. Annual progress report of the Department of Solid State Physics 1 January -31 December 1996

    International Nuclear Information System (INIS)

    Joergensen, M.; Bechgaard, K.; Clausen, K.N.; Feidenhans'l, R.; Johannsen, I.

    1997-01-01

    Research in the department is concerned with 'Materials with Distinct Physical and Chemical Properties'. The principal activities of the department in the period from 1 January to 31 December, 1996, are presented in this Progress Report. Neutron and x-ray diffraction techniques are used to study a wide variety of problems in condensed matter physics and include: two- and three-dimensional structures, magnetic ordering, heavy fermions, high T c superconductivity, phase transitions in model systems, precipitation phenomena, and nano-scale structures in various materials. The research in chemistry includes chemical synthesis and physico-chemical investigation of small molecules and polymers, with emphasis on polymers with new optical properties, block copolymers, surface modified polymers, and supramolecular structures. Related to these problems there is work going on in theory, Monte Carlo simulations, computer simulation of molecules and polymers and methods of data analysis. (au) 6 tabs., 144 ills., 197 refs

  13. Annual progress report of the Condensed Matter Physics and Chemistry Department 1 January - 31 December 1997

    International Nuclear Information System (INIS)

    Nielsen, M.; Bechgaard, K.; Clausen, K.N.; Feidenhans'l, R.; Johannsen, I.

    1998-01-01

    The Condensed Matter Physics and Chemistry Department is concerned with both fundamental and applied research into the physical and chemical properties of materials. The principal activities in the year 1997 are presented in this progress report. The research in physics in concentrated on neutron and x-ray scattering measurements and the problems studied include two- and three-dimensional structures, magnetic ordering and spin dynamics, superconductivity, phase transitions and nano-scale structures. The research in chemistry includes chemical synthesis and physico-chemical investigation of small molecules and polymers, with emphasis on polymers with new optical properties, block copolymers, surface-modified polymers, and supramolecular structures. Theoretical work related to these problems in undertaken, including Monte Carlo simulations, computer simulation of molecules and polymers and methods of data analysis. (au)

  14. Annual progress report of the Condensed Matter Physics and Chemistry Department 1 January - 31 December 1998

    International Nuclear Information System (INIS)

    Bechgaard, K.; Clausen, K.N.; Feidenhans'l, R.; Johannsen, I.

    1999-04-01

    The Condensed Matter Physics and Chemistry Department is concerned with both fundamental and applied research into the physical properties of materials. The principal activities in the year 1998 are presented in this progress report. The research in physics is concentrated on neutron and x-ray scattering measurements and the problems studied include two- and three-dimensional structures, magnetic ordering and spin dynamics, superconductivity, phase transitions and nano-scale structures. The research in chemistry includes chemical synthesis and physico-chemical investigation of small molecules and polymers, with emphasis on polymers with new optical properties, block copolymers, surface-modified polymers, and supramolecular structures. Theoretical work related to these problems is undertaken, including Monte Carlo simulations, computer simulation of molecules and polymers and methods of data analysis. (au)

  15. Fossil Energy Program annual progress report for April 1994 through March 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    This report covers progress made during the period April 1, 1994, through March 31, 1995, for research and development projects that contribute to the advancement of various fossil energy technologies. Projects on the Fossil Energy Program are supported by the DOE Office of Fossil Energy, and DOE Morgantown Energy Technology Center, the DOE Pittsburgh Energy Technology Center, the DOE Fossil Energy Clean Coal Technology Program, the DOE Bartlesville Project Office, and the DOE Fossil Energy Office of Strategic Petroleum Reserve. The following research areas are covered in this report: Materials research and development; Environmental analysis support; Bioprocessing research; Coal combustion research; and Fossil fuels supplies modeling and research. Selected papers have been processed separately for inclusion in the Energy Science an Technology database.

  16. Analytical Chemistry Division. Annual progress report for period ending December 31, 1981

    International Nuclear Information System (INIS)

    Lyon, W.S.

    1982-04-01

    The functions of the Analytical Chemistry Division fall into three general categories: (1) analytical research, development, and implementation; (2) programmatic research, development and utilization; (3) technical support. The Division is organized into five major sections each of which may carry out any type of work falling into the thre categories mentioned above. Chapters 1 through 5 of this report highlight progress within the five sections which are: analytical methodology; mass and emission spectrometry; analytical technical support; bio/organic analysis section; and nuclear and radiochemical analysis. A short summary introduces each chapter to indicate work scope. Information about quality assurance and safety programs is presented in Chapter 6, along with a tabulation of analyses rendered. Chapter 7 covers supplementary activities. Chapter 8 is on presentation of research results (publications, articles reviewed or referred for periodicals). Approximately 56 articles, 31 proceedings publications and 33 reports have been published, and 119 oral presentations given during this reporting period

  17. Spent Fuel and Waste Management Technology Development Program. Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Bryant, J.W.

    1994-01-01

    This report provides information on the progress of activities during fiscal year 1993 in the Spent Fuel and Waste Management Technology Development Program (SF&WMTDP) at the Idaho Chemical Processing Plant (ICPP). As a new program, efforts are just getting underway toward addressing major issues related to the fuel and waste stored at the ICPP. The SF&WMTDP has the following principal objectives: Investigate direct dispositioning of spent fuel, striving for one acceptable waste form; determine the best treatment process(es) for liquid and calcine wastes to minimize the volume of high level radioactive waste (HLW) and low level waste (LLW); demonstrate the integrated operability and maintainability of selected treatment and immobilization processes; and assure that implementation of the selected waste treatment process is environmentally acceptable, ensures public and worker safety, and is economically feasible.

  18. 1994 annual report on low-level radioactive waste management progress

    International Nuclear Information System (INIS)

    1995-04-01

    This report for calendar year 1994 summarizes the progress that states and compact regions made during the year in establishing new low-level radioactive waste disposal facilities. Although events that have occurred in 1995 greatly alter the perspective in terms of storage versus disposal, the purpose of this report is to convey the concerns as evidenced during calendar year 1994. Significant developments occurring in 1995 are briefly outlined in the transmittal letter and will be detailed in the report for calendar year 1995. The report also provides summary information on the volume of low-level radioactive waste received for disposal in 1994 by commercially operated low-level radioactive waste disposal facilities, and is prepared is in response to Section 7(b) of Title I of Public Law 99-240, the Low-Level Radioactive Waste Policy Amendments Act of 1985

  19. Fossil Energy Program annual progress report for April 1993 through March 1994

    Energy Technology Data Exchange (ETDEWEB)

    Judkins, R.R.

    1994-06-01

    This report covers progress made during the period April 1, 1993, through March 31, 1994, for research and development projects that contribute to the advancement of various fossil energy technologies. Projects on the Fossil Energy Program are supported by the DOE Office of Fossil Energy, the DOE Morgantown Energy Technology Center, the DOE Pittsburgh Energy Technology Center, the DOE Fossil Energy Clean Coal Technology Program, the DOE Bartlesville Project Office, the DOE Fossil Energy Office of Petroleum Reserves, and the US Agency for International Development. The five areas of research covered in this report are: Materials research and development; Environmental analysis and support; Bioprocessing; Coal combustion; and Fossil fuels supplies modeling and research. Selected papers have been processed separately for inclusion on the data base.

  20. Annual progress report of the Department of Solid State Physics 1 January -31 December 1994

    International Nuclear Information System (INIS)

    Lindgaard, P.-A.; Bechgaard, K.; Clausen, K.N.; Feidenhans'l, R.; Johannsen, I.

    1995-01-01

    Research in the department is concerned with 'Materials with Distinct Physical and Chemical Properties'. The principal activities of the department in the period from 1 January to 31 December, 1994, are presented in this Progress Report. Neutron and x-ray diffraction techniques are used to study a wide variety of problems in condensed matter physics and include: two- and three-dimensional structures, magnetic ordering, heavy fermions, high T c superconductivity, phase transitions in model systems, precipitation phenomena, and nano-scale structures in various materials. The research in chemistry includes chemical synthesis and physico-chemical investigation of small molecules and polymers, with emphasis on polymers with new optical properties, block copolymers, surface modified polymers, and supramolecular structures. Related to these problems there is work going on in theory, Monte Carlo simulations, and methods of data analysis. (au) (3 tabs., 116 ills., 181 refs.)

  1. Annual progress report of the Department of Solid State Physics 1 January - 31 December 1995

    International Nuclear Information System (INIS)

    Joergensen, M.; Bechgaard, K.; Clausen, K.N.; Feidenhans'l, R.; Johannsen, I.

    1996-01-01

    Research in the department is concerned with 'Materials with Distinct Physical and Chemical Properties'. The principal activities of the department in the period from 1 January to 31 December, 1995, are presented in this Progress Report. Neutron and x-ray diffraction techniques are used to study a wide variety of problems in condensed matter physics and include: two- and three-dimensional structures, magnetic ordering, heavy fermions, high T c superconductivity, phase transitions in model systems, precipitation phenomena, and nano-scale structures in various materials. The research in chemistry includes chemical synthesis and physico-chemical investigation of small molecules and polymers, with emphasis on polymers with new optical properties, block copolymers, surface modified polymers, and supramolecular structures. Related to these problems there is work going on in theory, Monte Carlo simulations, computer simulation of molecules and polymers and methods of data analysis. (au) 5 tabs., 135 ills., 163 refs

  2. Environmental Sciences Division annual progress report for period ending September 30, 1993

    International Nuclear Information System (INIS)

    1994-05-01

    This progress report summarizes the research and development activities conducted in the Environmental Sciences Division (ESD) of Oak Ridge National Laboratory during fiscal year (FY) 1993, which extended from October 1, 1992, through September 30, 1993. The report is structured to provide descriptions of current activities and accomplishments in each of the division's major organizational units. Following the sections describing the organizational units are sections highlighting ESD Scientific, Technical, and Administrative Achievement awards and listing information necessary to convey the scope of the work in the division. An organizational chart of staff and long-term guests who were in ESD and the end of FY 1993 is located in the final section of the report

  3. Annual progress report of the Condensed Matter Physics and Chemistry Department. 1 January - 31 December 1999

    International Nuclear Information System (INIS)

    Lebech, B.

    2000-02-01

    The Condensed Matter Physics and Chemistry Department is concerned with both fundamental and applied research into the physical and chemical properties of materials. The principal activities in the year 1999 are presented in this progress report. The research in physics is concentrated on neutron and x-ray scattering measurements and the problems studied include two- and three-dimensional structures, magnetic ordering and spin dynamics, superconductivity, phase transitions and nano-scale structures. The research in chemistry includes chemical synthesis and physico-chemical investigation of small molecules and polymers, with emphasis on polymers with new optical properties, block copolymers, surface-modified polymers, and supramolecular structures. Theoretical work related to these problems is undertaken, including Monte Carlo simulations, computer simulation of molecules and polymers and methods of data analysis. (au)

  4. Annual progress report of the Condensed Matter Physics and Chemistry Department 1 January - 31 December 1997

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, M.; Bechgaard, K.; Clausen, K.N.; Feidenhans`l, R.; Johannsen, I. [eds.

    1998-01-01

    The Condensed Matter Physics and Chemistry Department is concerned with both fundamental and applied research into the physical and chemical properties of materials. The principal activities in the year 1997 are presented in this progress report. The research in physics in concentrated on neutron and x-ray scattering measurements and the problems studied include two- and three-dimensional structures, magnetic ordering and spin dynamics, superconductivity, phase transitions and nano-scale structures. The research in chemistry includes chemical synthesis and physico-chemical investigation of small molecules and polymers, with emphasis on polymers with new optical properties, block copolymers, surface-modified polymers, and supramolecular structures. Theoretical work related to these problems in undertaken, including Monte Carlo simulations, computer simulation of molecules and polymers and methods of data analysis. (au). 129 ills., 213 refs.

  5. Environmental Sciences Division annual progress report for period ending September 30, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    This progress report summarizes the research and development activities conducted in the Environmental Sciences Division (ESD) of Oak Ridge National Laboratory during fiscal year (FY) 1994, which extended from October 1, 1993, through September 30, 1994. The report is structured to provide descriptions of current activities and accomplishments in each of the division`s major organizational units. Following the sections describing the organizational units are sections highlighting ESD Scientific, Technical, and Administrative Achievement awards and listing information necessary to covey the scope of the work in the division. An organizational chart of staff and long-term guests who wee in ESD at the end of FY 1994 is located in the final section of the report.

  6. Environmental Sciences Division annual progress report for period ending September 30, 1994

    International Nuclear Information System (INIS)

    1994-01-01

    This progress report summarizes the research and development activities conducted in the Environmental Sciences Division (ESD) of Oak Ridge National Laboratory during fiscal year (FY) 1994, which extended from October 1, 1993, through September 30, 1994. The report is structured to provide descriptions of current activities and accomplishments in each of the division's major organizational units. Following the sections describing the organizational units are sections highlighting ESD Scientific, Technical, and Administrative Achievement awards and listing information necessary to covey the scope of the work in the division. An organizational chart of staff and long-term guests who wee in ESD at the end of FY 1994 is located in the final section of the report

  7. Annual progress report - Health Sciences Division - 1990 January 01 - December 31

    International Nuclear Information System (INIS)

    1991-06-01

    This progress report contains a topical summary of major research in the Health Sciences Division. Separate reports are included for the Dosimetric Research Branch and the Radiation Biology Branch. The major topics discussed in this report include: neutron dosimetry, photon dosimetry, beta ray dosimetry, tritium measurement and dosimetry, internal dosimetry, biological dosimetry, instrumentation and measurement techniques, bioassay and in vivo counting development, dosimetry services, external activities, dose estimation by electron spin resonance, molecular and physical approaches to the structure and genetic function of DNA that determine cellular radioresponse, carcinogenic risks of radiation, stress induced changes in DNA structure and in cell biology, assessment of variation in the responses of individuals to ionizing radiation, cytotoxicity of beryllium, RBE of tritium beta rays for causes of death other than myeloid leukemia in male CBA/H mice, animal facility operations, and the Chalk River follow-up study

  8. Annual progress report of the Condensed Matter Physics and Chemistry Department. 1 January - 31 December 1999

    Energy Technology Data Exchange (ETDEWEB)

    Lebech, B. [ed.

    2000-02-01

    The Condensed Matter Physics and Chemistry Department is concerned with both fundamental and applied research into the physical and chemical properties of materials. The principal activities in the year 1999 are presented in this progress report. The research in physics is concentrated on neutron and x-ray scattering measurements and the problems studied include two- and three-dimensional structures, magnetic ordering and spin dynamics, superconductivity, phase transitions and nano-scalestructures. The research in chemistry includes chemical synthesis and physico-chemical investigation of small molecules and polymers, with emphasis on polymers with new optical properties, block copolymers, surface-modified polymers, and supramolecular structures. Theoretical work related to these problems is undertaken, including Monte Carlo simulations, computer simulation of molecules and polymers and methods of data analysis. (au)

  9. Nuclear structure theory. Annual technical progress report, 1 July 1974--30 June 1975

    International Nuclear Information System (INIS)

    French, J.B.; Koltun, D.S.

    1975-01-01

    Progress during the past year is summarized for the following areas of nuclear structure and reaction theory: Meson interactions with nucleons and nuclei, including inelastic scattering of pions, three-body theories of scattering and absorption of pions by deuterons, and π-p bremsstrahlung. Theory of the effective interaction, including behavior of the expansion in orders of the reaction matrix. Statistical spectroscopy including fluctuations in energy levels and excitation strengths, and sum rules and strength distributions for various excitation processes, including single-nucleon transfer, β decay and multipole giant resonances. Studies of the inverse scattering problem. Studies of nuclear symmetries, of nuclear clustering, and of general nuclear structure by α-transfer reactions, and of nuclear shapes by (d, 3 He) reactions. (U.S.)

  10. Annual progress report of the Department of Solid State Physics 1 January -31 December 1996

    Energy Technology Data Exchange (ETDEWEB)

    Joergensen, M.; Bechgaard, K.; Clausen, K.N.; Feidenhans`l, R.; Johannsen, I.

    1997-01-01

    Research in the department is concerned with `Materials with Distinct Physical and Chemical Properties`. The principal activities of the department in the period from 1 January to 31 December, 1996, are presented in this Progress Report. Neutron and x-ray diffraction techniques are used to study a wide variety of problems in condensed matter physics and include: two- and three-dimensional structures, magnetic ordering, heavy fermions, high T{sub c} superconductivity, phase transitions in model systems, precipitation phenomena, and nano-scale structures in various materials. The research in chemistry includes chemical synthesis and physico-chemical investigation of small molecules and polymers, with emphasis on polymers with new optical properties, block copolymers, surface modified polymers, and supramolecular structures. Related to these problems there is work going on in theory, Monte Carlo simulations, computer simulation of molecules and polymers and methods of data analysis. (au) 6 tabs., 144 ills., 197 refs.

  11. MHD air heater technology development. Annual technical progress report, January 1, 1980-December 31, 1980

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-03-01

    Progress on the technology development of the directly-fired high temperature air heater (HTAH) for MHD power plants is described in detail. The objective of task 1 is to continue development of ceramic materials technology for the directly-fired HTAH. The objectives of task 2 are to demonstrate the technical feasibility of operating a directly-fired HTAH (including both the heater matrix and valves), to continue obtaining information on life and corrosion resistance of HTAH materials, and to obtain design information for full-scale studies and future design work. The objectives of task 3 are to begin the identification of HTAH control requirements and control system needs, and to continue full-scale study efforts incorporating updated materials and design information in order to identify development needs for the HTAH development program. (WHK)

  12. Fossil Energy Program Annual Progress Report for the Period April 1, 2000 through March 31, 2001

    Energy Technology Data Exchange (ETDEWEB)

    Judkins, RR

    2001-06-14

    This report covers progress made at Oak Ridge National Laboratory (ORNL) on research and development projects that contribute to the advancement of fossil energy technologies. Projects on the ORNL Fossil Energy Program are supported by the U.S. Department of Energy (DOE) Office of Fossil Energy, the DOE National Energy Technology Laboratory (NETL), the DOE Fossil Energy Clean Coal Technology (CCT) Program, the DOE National Petroleum Technology Office, and the DOE Fossil Energy Office of Strategic Petroleum Reserve (SPR). The ORNL Fossil Energy Program research and development activities cover the areas of coal, clean coal technology, gas, petroleum, and support to the SPR. An important part of the Fossil Energy Program is technical management of all activities on the DOE Fossil Energy Advanced Research (AR) Materials Program. The AR Materials Program involves research at other DOE and government laboratories, at universities, and at industrial organizations.

  13. Metals and Ceramics Division materials science annual progress report for period ending June 30, 1977

    International Nuclear Information System (INIS)

    McHargue, C.J.

    1977-09-01

    Progress is reported for research programs in the metals and ceramics division of ORNL. In structure of materials, theoretical research, x-ray diffraction studies, studies of erosion of ceramics, preparation and synthesis of high temperature and special service materials, and studies of stabilities of microphases in high-temperature structural materials. Research into deformation and mechanical properties included physical metallurgy, and grain boundary segregation and embrittlement. Physical properties and transport phenomena were studied and included mechanisms of surface and solid state reactions, and properties of superconducting materials. The radiation effects program, directed at understanding the effects of composition and microstructure on the structure and properties of materials irradiated at elevated temperatures, is also described

  14. Analytical Chemistry Division. Annual progress report for period ending December 31, 1981

    Energy Technology Data Exchange (ETDEWEB)

    Lyon, W. S. [ed.

    1982-04-01

    The functions of the Analytical Chemistry Division fall into three general categories: (1) analytical research, development, and implementation; (2) programmatic research, development and utilization; (3) technical support. The Division is organized into five major sections each of which may carry out any type of work falling into the thre categories mentioned above. Chapters 1 through 5 of this report highlight progress within the five sections which are: analytical methodology; mass and emission spectrometry; analytical technical support; bio/organic analysis section; and nuclear and radiochemical analysis. A short summary introduces each chapter to indicate work scope. Information about quality assurance and safety programs is presented in Chapter 6, along with a tabulation of analyses rendered. Chapter 7 covers supplementary activities. Chapter 8 is on presentation of research results (publications, articles reviewed or referred for periodicals). Approximately 56 articles, 31 proceedings publications and 33 reports have been published, and 119 oral presentations given during this reporting period.

  15. Metals and Ceramics Division materials science annual progress report for period ending June 30, 1977

    Energy Technology Data Exchange (ETDEWEB)

    McHargue, C.J. (comp.)

    1977-09-01

    Progress is reported for research programs in the metals and ceramics division of ORNL. In structure of materials, theoretical research, x-ray diffraction studies, studies of erosion of ceramics, preparation and synthesis of high temperature and special service materials, and studies of stabilities of microphases in high-temperature structural materials. Research into deformation and mechanical properties included physical metallurgy, and grain boundary segregation and embrittlement. Physical properties and transport phenomena were studied and included mechanisms of surface and solid state reactions, and properties of superconducting materials. The radiation effects program, directed at understanding the effects of composition and microstructure on the structure and properties of materials irradiated at elevated temperatures, is also described. (GHT)

  16. Studies of carbon--isotope fractionation. Annual progress report, December 1, 1974--November 30, 1975

    Energy Technology Data Exchange (ETDEWEB)

    Ishida, T.

    1975-12-01

    The vapor pressure isotope effect of /sup 13/C//sup 12/C-substitution in CClF/sub 3/ was measured at temperatures between 169/sup 0/ and 206/sup 0/K by means of cryogenic distillation. The /sup 13/C//sup 12/C-vapor pressure isotope effect in CHF/sub 3/ was also studied at temperatures between 161/sup 0/ and 205/sup 0/K by a similar method. The construction of a cryostat has progressed as scheduled. The investigation of carbon isotope exchange equilibria between carbon dioxide and various carbamates dissolved in various organic solvents has continued. The five-stage system of Taylor-Ghate design was improved to shorten the transient time. A single stage apparatus was designed, built, and tested. These systems are used to measure the equilibrium constants and various phase equilibria involved in the carbon dioxide--carbamate system. The investigation of the explicit method of total isotope effect has made progress. A satisfactory approximation was found for the classical partition function of a Morse oscillator. The method gives a reasonable result at rho identical with /sup 1///sub 2/..sqrt..(u/sub e//x/sub e/) greater than 1.5. The medium cluster approach was applied to isotopic methanes to investigate the effects of intermolecular distance and mutual orientations of molecules in the liquid upon vapor pressure isotope effect. It was found that all geometrical effects studied tend to vanish as the size of clusters is increased. Isotope effect in the zero-point energy shifts on condensation was calculated on the basis of London dispersion forces in liquid and a semi-empirical molecular orbital theory, and was favorably compared with experimental results. (auth)

  17. Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma

    Science.gov (United States)

    Jalbert, Llewellyn E.; Elkhaled, Adam; Phillips, Joanna J.; Neill, Evan; Williams, Aurelia; Crane, Jason C.; Olson, Marram P.; Molinaro, Annette M.; Berger, Mitchel S.; Kurhanewicz, John; Ronen, Sabrina M.; Chang, Susan M.; Nelson, Sarah J.

    2017-03-01

    Infiltrating low grade gliomas (LGGs) are heterogeneous in their behavior and the strategies used for clinical management are highly variable. A key factor in clinical decision-making is that patients with mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) oncogenes are more likely to have a favorable outcome and be sensitive to treatment. Because of their relatively long overall median survival, more aggressive treatments are typically reserved for patients that have undergone malignant progression (MP) to an anaplastic glioma or secondary glioblastoma (GBM). In the current study, ex vivo metabolic profiles of image-guided tissue samples obtained from patients with newly diagnosed and recurrent LGG were investigated using proton high-resolution magic angle spinning spectroscopy (1H HR-MAS). Distinct spectral profiles were observed for lesions with IDH-mutated genotypes, between astrocytoma and oligodendroglioma histologies, as well as for tumors that had undergone MP. Levels of 2-hydroxyglutarate (2HG) were correlated with increased mitotic activity, axonal disruption, vascular neoplasia, and with several brain metabolites including the choline species, glutamate, glutathione, and GABA. The information obtained in this study may be used to develop strategies for in vivo characterization of infiltrative glioma, in order to improve disease stratification and to assist in monitoring response to therapy.

  18. Tumor progression locus 2 (Tpl2 deficiency does not protect against obesity-induced metabolic disease.

    Directory of Open Access Journals (Sweden)

    Graeme I Lancaster

    Full Text Available Obesity is associated with a state of chronic low grade inflammation that plays an important role in the development of insulin resistance. Tumor progression locus 2 (Tpl2 is a serine/threonine mitogen activated protein kinase kinase kinase (MAP3K involved in regulating responses to specific inflammatory stimuli. Here we have used mice lacking Tpl2 to examine its role in obesity-associated insulin resistance. Wild type (wt and tpl2(-/- mice accumulated comparable amounts of fat and lean mass when fed either a standard chow diet or two different high fat (HF diets containing either 42% or 59% of energy content derived from fat. No differences in glucose tolerance were observed between wt and tpl2(-/- mice on any of these diets. Insulin tolerance was similar on both standard chow and 42% HF diets, but was slightly impaired in tpl2(-/- mice fed the 59% HFD. While gene expression markers of macrophage recruitment and inflammation were increased in the white adipose tissue of HF fed mice compared with standard chow fed mice, no differences were observed between wt and tpl2(-/- mice. Finally, a HF diet did not increase Tpl2 expression nor did it activate Extracellular Signal-Regulated Kinase 1/2 (ERK1/2, the MAPK downstream of Tpl2. These findings argue that Tpl2 does not play a non-redundant role in obesity-associated metabolic dysfunction.

  19. The Umatilla Basin Natural Production Monitoring and Evaluation Project, 2008 Annual Progress Report.

    Energy Technology Data Exchange (ETDEWEB)

    Contor, Craig R.; Harris, Robin; King, Marty [Confederated Tribes of the Umatilla Indian Reservation

    2009-06-10

    The Umatilla Basin Natural Production Monitoring and Evaluation Project (UBNPMEP) is funded by Bonneville Power Administration (BPA) as directed by section 4(h) of the Pacific Northwest Electric Power Planning and Conservation Act of 1980 (P.L.96-501). This project is in accordance with and pursuant to measures 4.2A, 4.3C.1, 7.1A.2, 7.1C.3, 7.1C.4 and 7.1D.2 of the Northwest Power Planning Council's (NPPC) Columbia River Basin Fish and Wildlife Program (NPPC 1994). Work was conducted by the Fisheries Program of the Confederated Tribes of the Umatilla Indian Reservation (CTUIR). The UBNPMEP is coordinated with two Oregon Department of Fish and Wildlife (ODFW) research projects that also monitor and evaluate the success of the Umatilla Fisheries Restoration Plan. This project deals with the natural production component of the plan, and the ODFW projects evaluate hatchery operations (project No. 1990-005-00, Umatilla Hatchery M & E) and smolt outmigration (project No. 1989-024-01, Evaluation of Juvenile Salmonid Outmigration and Survival in the Lower Umatilla River). Collectively these three projects monitor and evaluate natural and hatchery salmonid production in the Umatilla River Basin. The need for natural production monitoring has been identified in multiple planning documents including Wy-Kan-Ush-Mi Wa-Kish-Wit Volume I, 5b-13 (CRITFC 1996), the Umatilla Hatchery Master Plan (CTUIR & ODFW 1990), the Umatilla Basin Annual Operation Plan, the Umatilla Subbasin Summary (CTUIR & ODFW 2001), the Subbasin Plan (CTUIR & ODFW 2004), and the Comprehensive Research, Monitoring, and Evaluation Plan (CTUIR and ODFW 2006). Natural production monitoring and evaluation is also consistent with Section III, Basinwide Provisions, Strategy 9 of the 2000 Columbia River Basin Fish and Wildlife Program (NPPC 1994, NPCC 2004). The Umatilla Basin M&E plan developed along with efforts to restore natural populations of spring and fall Chinook salmon, (Oncorhynchus tshawytsha), coho

  20. The Community's research and development programme on decommissioning of nuclear installations: First annual progress report (year 1985)

    International Nuclear Information System (INIS)

    1986-01-01

    This is the first Annual Progress Report of the European Community's 1984-88 programme of research on the decommissioning of nuclear installations. It shows the status of implementation reached on 31 December 1985. The 1984-88 programme has the following contents: A. Research and development projects concerning the following subjects: Project No 1: Long-term integrity of building and systems; Project No 2: Decontamination for decommissioning purposes; Project No 3: Dismantling techniques; Project No 4: Treatment of specific waste materials: steel, concrete and graphite; Project No 5: Large containers for radioactive waste produced in the dismantling of nuclear installations; Project No 6: Estimation of the quantities of radioactive wastes arising from the decommissioning of nuclear installations in the Community; Project No 7: Influence of installation design features on decommissioning. B. Identification of guiding principles, namely: - certain guiding principles in the design and operation of nuclear installations with a view to simplifying their subsequent decommissioning, - guiding principles in the decommissioning of nuclear installations which could form the initial elements of a Community policy in this field. C. Testing of new techniques under real conditions, within the framework of large-scale decommissioning operations undertaken in Member States. This first progress report, covering the period of putting the programme into action, describes the work to be carried out under the 27 research contracts concluded, as well as initial work performed and first results obtained

  1. Captive Rearing Program for Salmon River Chinook Salmon : Project Progress Report, 2001 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Venditti, David A.

    2003-10-01

    distributed themselves throughout the study section and displayed a progression of habitat associations and behavior consistent with progressing maturation and the onset of spawning. Five of the 18 redds spawned by captive-reared parents were hydraulically sampled to assess survival to the eyed stage of development. Eyed-eggs were collected from four of these, and survival to this stage ranged from 0%-89%. Expanding these results to the remaining redds produced an estimate of 15,000 eyed-eggs being produced by captive-reared fish.

  2. Acid-base behavior in hydrothermal processing of wastes. 1997 annual progress report

    International Nuclear Information System (INIS)

    1997-01-01

    'A major obstacle to the development of hydrothermal technology for treating DOE wastes has been a lack of scientific knowledge of solution chemistry, thermodynamics and transport phenomena. The progress over the last year is highlighted in the following four abstracts from manuscripts which have been submitted to journals. The authors also have made considerable progress on a spectroscopic study of the acid-base equilibria of Cr(VI). They have utilized novel spectroscopic indicators to study acid-base equilibria up to 380 C. Until now, very few systems have been studied at such high temperatures, although this information is vital for hydrothermal processing of wastes. The pH values of aqueous solutions of boric acid and KOH were measured with the optical indicator 2-naphthol at temperatures from 300 to 380 C. The equilibrium constant Kb-l for the reaction B(OH)3 + OH - = B(OH) -4 was determined from the pH measurements and correlated with a modified Born model. The titration curve for the addition of HCl to sodium borate exhibits strong acid-strong base behavior even at 350 C and 24.1 MPa. At these conditions, aqueous solutions of sodium borate buffer the pH at 9.6 t 0.25. submitted to Ind. Eng. Chem. Res. Acetic Acid and HCl Acid-base titrations for the KOH-acetic acid or NH 3 -acetic acid systems were monitored with the optical indicator 2-naphthoic acid at 350 C and 34 MPa, and those for the HCl;Cl- system with acridine at 380 C and up to 34 MPa (5,000 psia ). KOH remains a much stronger base than NH,OH at high temperature. From 298 K to the critical temperature of water, the dissociation constant for HCl decreases by 13 orders of magnitude, and thus, the basicity of Cl - becomes significant. Consequently, the addition of NaCl to HCl raises the pH. The pH titration curves may be predicted with reasonable accuracy from the relevant equilibrium constants and Pitzer''s formulation of the Debye- Htickel equation for the activity coefficients.'

  3. Fifth annual progress report for Canada's climate change voluntary challenge and registry program

    International Nuclear Information System (INIS)

    1999-10-01

    Suncor Energy is a growing Canada-based integrated energy company comprising a corporate group and four operating businesses including: Oil Sands with a mine and upgrading facility at Fort McMurray, AB, Exploration and Production with conventional and heavy oil business in Western Canada, a Sunoco refining and marketing operation, and the Stuart Oil Shale Development Project in Queensland, Australia. While the emphasis is laid on technical and economic advances made by the company, the environmental tradeoffs, namely, greater greenhouse gas emissions and the need to reduce them, are noted. The most important positive item in the report is the incredible transformation occurring in Suncor's business operations. The company has begun a $2 billion expansion in its Oil Sands business that will more than double production of crude oil and fuel products by 2002. The expansion initiative provides a wonderful opportunity to demonstrate the huge leaps in performance that can be implemented at the time of capital stock turnover. The new expansion facilities are designed to be twice as energy efficient as the existing plant. Equally dramatic and hard won, are the multitude of incremental improvements achieved in existing facilities. Through energy management systems and operating practices and procedures, exploration and production is reversing the trend of rising greenhouse gas (GHG) emission intensity associated with mature conventional reservoirs, and Suncoco achieved its best ever operating performance in 1998. However, the volume of Suncor greenhouse gas emissions remains on an upward trend, which is a challenge for the future. As part of its mission to become a sustainable energy company, Suncor will continue to attempt to limit its net volume contribution of GHGs to the atmosphere to 1990 levels by pursuing domestic and international offsets and the development of alternative and renewable sources of energy. Progress towards sustainability for both Suncor and Canada

  4. Determining significant endpoints for ecological risk analyses. 1998 annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Hinton, T.G.; Congdon, J.; Scott, D. [Univ. of Georgia, Aiken, SC (US). Savannah River Ecology Lab.; Rowe, C. [Univ. of Puerto Rico, San Juan (PR); Bedford, J.; Whicker, W. [Colorado State Univ., Fort Collins, CO (US)

    1998-06-01

    'The goal of this report is to establish a protocol for assessing risks to non-human populations exposed to environmental stresses typically found on many DOE sites. The authors think that they can achieve this by using novel biological dosimeters in controlled, manipulative dose/effects experiments, and by coupling changes in metabolic rates and energy allocation patterns to meaningful population response variables (such as age-specific survivorship, reproductive output, age at maturity and longevity). This research is needed to determine the relevancy of sublethal cellular damage to the performance of individuals and populations exposed to chronic, low-level radiation, and radiation with concomitant exposure to chemicals. They believe that a scientifically defensible endpoint for measuring ecological risks can only be determined once its understood the extent to which molecular damage from contaminant exposure is detrimental at the individual and population levels of biological organization. The experimental facility will allow them to develop a credible assessment tool for appraising ecological risks, and to evaluate the effects of radionuclide/chemical synergisms on non-human species. This report summarizes work completed midway of a 3-year project that began in November 1996. Emphasis to date has centered on three areas: (1) developing a molecular probe to measure stable chromosomal aberrations known as reciprocal translocations, (2) constructing an irradiation facility where the statistical power inherent in replicated mesocosms can be used to address the response of non-human organisms to exposures from low levels of radiation and metal contaminants, and (3) quantifying responses of organisms living in contaminated mesocosms and field sites.'

  5. Environmental Sciences Division annual progress report for period ending September 30, 1990

    International Nuclear Information System (INIS)

    1991-04-01

    The Environmental Sciences Division (ESD) of Oak Ridge National Laboratory (ORNL) conducts research on the environmental aspects of existing and emerging energy systems and applies this information to ensure that technology development and energy use are consistent with national environmental health and safety goals. Offering an interdisciplinary resource of staff and facilities to address complex environmental problems, the division is currently providing technical leadership for major environmental issues of national concern: (1) acidic deposition and related environmental effects, (2) effects of increasing concentrations of atmospheric CO 2 and the resulting climatic changes to ecosystems and natural and physical resources, (3) hazardous chemical and radioactive waste disposal and remediation research and development, and (4) development of commercial biomass energy production systems. This progress report outlines ESD's accomplishments in these and other areas in FY 1990. Individual reports are processed separately for the data bases in the following areas: ecosystem studies; environmental analyses; environmental toxicology; geosciences; technical and administrative support; biofuels feedstock development program; carbon dioxide information analysis and research program; and environmental waste program

  6. Experimental Medium Energy Physics annual progress report, June 1984-May 1985

    International Nuclear Information System (INIS)

    1985-01-01

    During the past year the principal activities of the CMU Medium Energy Physics Group have included the running of three previously approved experiments, the development of hardware and software for these experiments, and final analysis of previously accumulated data. In a two week run at LEAR at the beginning of this year 100 data tapes were collected on experiment PS-185. This spring sigma hyperon production in Lithium was studied in a run on AGS experiment E-774. We are currently setting up AGS experiment E-788 in an investigation of Lambda weak decay in Helium hypernuclei. In addition a new experiment to search for strangeness S = -2 dibaryon production was presented and approved by the AGS program advisory committee for 1000 h (E-813). For these experiments extensive hardware and software development has taken place, requiring much of the group's effort. Analysis of LEAR experiment PS-185 is in full progress at CMU. Both the weak decay studies of 12 C (AGS E-759) and the pion annihilation studies in Lithium and Oxygen have now been fully analyzed with the results submitted for publication in several papers. All of these activities are described. Specific hardware and software projects are discussed

  7. Exploratory research on solvent refined coal liquefaction. Annual technical progress report, January 1-December 31, 1979

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-09-01

    This report summarizes the progress of the Exploratory Research on Solvent Refined Coal Liquefaction project by The Pittsburg and Midway Coal Mining Co.'s Merriam Laboratory during 1979. In a series of experiments with varying feed gas composition, low levels (5 to 10 mole %) of carbon monoxide had little effect on the SRC II processing of Pittsburgh Seam coal (Powhatan No. 5 Mine) while higher levels (20 to 40 mole %) resulted in a general degradation of operability and reduced oil yields. Addition of finely divided (approx. 1 ..mu..m) pyrite to the reactive Powhatan coal had little effect on oil yields although the molecular weight of the distillation residue was apparently decreased. When finely divided pyrite and magnetite were added to the less reactive coals from the Loveridge and Blacksville No. 1 Mines (also Pittsburgh Seam), however, substantial increases in oil yields and product quality were obtained. In a comparison of upflow and downflow dissolver configurations with Powhatan coal in the SRC II mode, there was no difference in yields or product quality. A study characterizing specific reactors revealed a significantly higher conversion in the SRC I mode with a reactor approximating plug flow conditions compared to a completely backmixed reactor. In the SRC II mode there was only a slightly higher oil yield with the plug flow reactor.

  8. Interfacial radiolysis effects in tank waste speciation. 1998 annual progress report

    International Nuclear Information System (INIS)

    Camaioni, D.; Meisel, D.; Orlando, T.M.

    1998-01-01

    'The purpose of this program is to deliver pertinent, fundamental information that can be used to make technically defensible decisions on safety issues and processing strategies associated with storage and clean up of DOE mixed chemical and radioactive wastes. The radioactive and chemical wastes present in DOE underground storage tanks contain complex mixtures of sludges, salts, and supernatant liquids. These mixtures, which contain a wide variety of oxide materials, aqueous solvents, and organic components, are constantly bombarded with gamma quanta, beta and alpha particles produced via the decay of radioactive isotopes. Currently, there is a vital need to understand radiolysis of organic and inorganic species present in mixed waste tanks because these processes: (a) produce mixtures of toxic, flammable, and potentially explosive gases (i.e., H 2 , N 2 O and volatile organics) (b) degrade organics, possibly to gas-generating organic fragments, even as the degradation reduces the hazards associated with nitrate-organic mixtures, (c) alter the surface chemistry of insoluble colloids in tank sludge, influencing sedimentation and the gas/solid interactions that may lead to gas entrapment phenomena. This report summarizes the technical achievements of a 3-year project that is now in its 2nd year. Progress in three areas is reported: (1) radiation effects at NaNO 3 crystal interfaces, (2) reactions of organic complexants with NO 2 in water, and (3) radiation effects in oxide particles.'

  9. Analytical Chemistry Division annual progress report for period ending December 31, 1988

    Energy Technology Data Exchange (ETDEWEB)

    1988-05-01

    The Analytical Chemistry Division of Oak Ridge National Laboratory (ORNL) is a large and diversified organization. As such, it serves a multitude of functions for a clientele that exists both in and outside of ORNL. These functions fall into the following general categories: (1) Analytical Research, Development, and Implementation. The division maintains a program to conceptualize, investigate, develop, assess, improve, and implement advanced technology for chemical and physicochemical measurements. Emphasis is on problems and needs identified with ORNL and Department of Energy (DOE) programs; however, attention is also given to advancing the analytical sciences themselves. (2) Programmatic Research, Development, and Utilization. The division carries out a wide variety of chemical work that typically involves analytical research and/or development plus the utilization of analytical capabilities to expedite programmatic interests. (3) Technical Support. The division performs chemical and physicochemical analyses of virtually all types. The Analytical Chemistry Division is organized into four major sections, each of which may carry out any of the three types of work mentioned above. Chapters 1 through 4 of this report highlight progress within the four sections during the period January 1 to December 31, 1988. A brief discussion of the division's role in an especially important environmental program is given in Chapter 5. Information about quality assurance, safety, and training programs is presented in Chapter 6, along with a tabulation of analyses rendered. Publications, oral presentations, professional activities, educational programs, and seminars are cited in Chapters 7 and 8.

  10. Analytical Chemistry Division annual progress report for period ending December 31, 1982

    Energy Technology Data Exchange (ETDEWEB)

    Lyon, W.S. (ed.)

    1983-05-01

    The Analytical Chemistry Dvision of Oak Ridge National laboratory (ORNL) serves a multitude of functions for a clientele that exists both in and outside ORNL. These functions fall into the following general categories: (1) analytical research, development, and implementation; (2) programmatic research, development, and utilization; and (3) technical support. The Division is organized into five major sections, each of which may carry out any type of work falling in the three categories mentioned above. Chapters 1 through 5 of this report highlight progress within the five sections (analytical methodology, mass and emission spectrometry, radioactive materials, bio/organic analysis, and general and environmental analysis) during the period January 1, 1982 to December 31, 1982. A short summary introduces each chapter to indicate work scope. Information about quality assurance and safety programs is presented in Chapter 6, along with a tabulation of analyses rendered. Publications, oral presentations, professional activities, educational programs, and seminars are cited in Chapters 7 and 8. Approximately 61 articles, 32 proceedings publications and 37 reports have been published, and 107 oral presentations were given during this reporting period.

  11. Survey of protected terrestrial vertebrates on the Oak Ridge Reservation 1995 annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Vail, E.R.; Mitchell, J.M.; Webb, J.W.; King, A.L.; Hamlett, P.A.

    1995-11-01

    This progress report discusses surveys of protected terrestrial vertebrates on the Oak Ridge Reservation (ORR) from October 1994 through September 1995. These surveys are important to help avoid or minimize potential impacts of projects on the ORR to species listed as threatened, endangered, or in need of management by the US Fish and Wildlife Service and the Tennessee Wildlife Resources Agency. Currently, there are 69 species of federally or state-listed terrestrial vertebrates that may occur in Tennessee. Not all of these are expected to occur on the ORR, nor do resources permit comprehensive sampling for all of them over the entire ORR. To effectively organize sampling efforts, listed animal species that might be present were targeted using a prioritization system based on historical and recent sightings, species distributions, literature reviews, and personal communications. Sampling was conducted during the time of the year when each targeted species would most likely be encountered. Several trapping and surveying methods were used, including pitfall traps, Sherman traps, seining, artificial covers, and cave and avian surveys.

  12. Analytical Chemistry Division annual progress report for period ending December 31, 1989

    International Nuclear Information System (INIS)

    1990-04-01

    The Analytical Chemistry Division of Oak Ridge National Laboratory (ORNL) is a large and diversified organization. As such, it serves a multitude of functions for a clientele that exists both in and outside of ORNL. These functions fall into the following general categories: Analytical Research, Development and Implementation; Programmatic Research, Development, and Utilization; and Technical Support. The Analytical Chemistry Division is organized into four major sections, each which may carry out any of the three types of work mentioned above. Chapters 1 through 4 of this report highlight progress within the four sections during the period January 1 to December 31, 1989. A brief discussion of the division's role in an especially important environmental program is given in Chapter 5. Information about quality assurance, safety, and training programs is presented in Chapter 6, along with a tabulation of analyses rendered. Publications, oral presentations, professional activities, educational programs, and seminars are cited in Chapters 7 and 8. Approximately 69 articles, 41 proceedings, and 31 reports were published, and 151 oral presentations were given during this reporting period. Some 308,981 determinations were performed

  13. Human genetic marker for resistance to radiations and chemicals. 1998 annual progress report

    International Nuclear Information System (INIS)

    Lieberman, H.B.

    1998-01-01

    'The broad objective of the project is to understand the molecular basis for the response of cells to radiations and chemicals, with the pragmatic goal of being able to identify human subpopulations that are exceptionally sensitive to DNA damaging agents. The project focuses on HRAD9, a human orthologue of the fission yeast Schizosaccharomyces pombe gene rad9. S. pombe rad9::ura4+ mutant cells are highly sensitive to ionizing radiation, UV and many chemicals, such as the DNA synthesis inhibitor hydroxyurea. They also lack the ability to delay cycling transiently in S phase or in G2 following a block in DNA replication or after incurring DNA damage, respectively -i.e., they lack checkpoint controls. The attempt by mutant cells to progress through mitosis in the absence of fully intact DNA accounts at least in part for their sensitivity to DNA damaging agents. Cells bearing rad9::ura4+ also aberrantly regulate UVDE, an enzyme that participates in a secondary DNA excision repair pathway. The key role played by S. pombe rad9 in promoting resistance to chemicals and radiations suggests that the evolutionarily conserved human cognate also has important functions in mammals. The first set of aims in this proposal centers on characterizing the structure and expression of HRAD9, to assess structure/function relationships and potentially link protein activity to a specific tissue. The next set of aims focuses on determining the role of HRAD9 in radio/chemoresponsiveness and cancer.'

  14. Annual progress report of the Department of Solid State Physics 1 January - 31 December 1993

    International Nuclear Information System (INIS)

    Skov Pedersen, J.; Almdal, K.; Feidenhans'l, R.; Clausen, K.N.; Bechgaard, K.

    1994-01-01

    Research in the department is concerned with ''Materials with Distinct Physical and Chemical Properties''. The principal activities of the department in the period from 1 January, to 31 December, 1993, are presented in this Progress Report. Neutrons and X-ray diffraction techniques are used to study a wide variety of problems in condensed matter physics and include: two- and three-dimensional structures, magnetic ordering, heavy fermions, high T c superconductivity, phase transitions in model systems, precipitation phenomena, and nanoscale structures in various materials. The research in chemistry includes chemical synthesis and physico-chemical investigations of small molecules and polymers, with emphasis on polymers with new optical properties, block copolymers, surface modified polymers, and supramolecular structures. This report is organized in 13 categories with the following headings: Theory, Monte Carlo simulations, and methods of data analysis. Magnetic structures, magnetic phase transitions, and spin dynamics. High T c superconductivity. Structures and structural phase transitions. Inclusions and precipitates in alloys and metals. Interaction of particles and photons with surfaces. Surfaces, interfaces, and amorphous structures. Langmuir films. Polymers. Molecular science. Microemulsions and biological systems. Instrument developments. Other activities. (au) (4 tabs., 109 ills., 168 refs.)

  15. Annual progress report of the Department of Solid State Physics 1. January - 31 December 1992

    International Nuclear Information System (INIS)

    Skov Pedersen, J.; Lebech, B.; Lindgaard, P.-A.

    1993-01-01

    Research in the department is in the field of condensed matter physics. The principal activities of the department in the period from 1 january, to 31 December, 1992, are presented in this Progress Report. The department's research is predominantly experimental - utilising diffraction of neutrons and X-rays - and includes studies of two- and three-dimensional structures, magnetic ordering, heavy fermions, high T c superconductivity, phase transitions in model systems, precipitation phenomena, and nano-scale structures in various materials. The major interest of the department is in basic research but projects of a more applied nature are often up, prompted by the applicability of the developed techniques and expertise. For clarity, the contributions to this report are organized into 12 categories with the following headings: Theory, Monte Carlo simulations, and methods for data analysis. Magnetic structures, magnetic phase transitions,and spin dynamics. High T c superconductivity. Structures and structural phase transitions. Inclusions and precipitates in alloys and metals. Interaction of particles and photons with surfaces. Surfaces, interfaces, and amorphous structures. Langmuir films. Polymers. Microemulsions and biological systems. Instrumental developments. Other activities. (au) (1 tab., 101 ills., 165 refs.)

  16. Analytical Chemistry Division annual progress report for period ending December 31, 1989

    Energy Technology Data Exchange (ETDEWEB)

    1990-04-01

    The Analytical Chemistry Division of Oak Ridge National Laboratory (ORNL) is a large and diversified organization. As such, it serves a multitude of functions for a clientele that exists both in and outside of ORNL. These functions fall into the following general categories: Analytical Research, Development and Implementation; Programmatic Research, Development, and Utilization; and Technical Support. The Analytical Chemistry Division is organized into four major sections, each which may carry out any of the three types of work mentioned above. Chapters 1 through 4 of this report highlight progress within the four sections during the period January 1 to December 31, 1989. A brief discussion of the division's role in an especially important environmental program is given in Chapter 5. Information about quality assurance, safety, and training programs is presented in Chapter 6, along with a tabulation of analyses rendered. Publications, oral presentations, professional activities, educational programs, and seminars are cited in Chapters 7 and 8. Approximately 69 articles, 41 proceedings, and 31 reports were published, and 151 oral presentations were given during this reporting period. Some 308,981 determinations were performed.

  17. Ion beam probe plasma diagnostic system. Annual progress report, 1 February 1976--31 January 1977

    International Nuclear Information System (INIS)

    Jennings, W.C.; Connor, K.A.; Hickok, R.L.

    1977-01-01

    The major thrust of this program has been to place the research tokamak facility, RENTOR, in operation and to develop the diagnostic systems to be used on this facility. Tokamak discharges lasting approx.1 msec are routinely produced, with the lifetime limited by magnetic field errors introduced by the large diagnostic boxes. Fine tuning of the fields is presently in progress. A complete heavy ion beam probe system has been constructed and is partially installed. A Thomson scattering experiment has also been developed and is scheduled for installation in the near future. The ten-channel data acquisition system has also been placed in operation with a completely designed computer interface system. In addition several improvements have been made in our minicomputer capabilities in terms of data processing and calculation of ion trajectories. The theory for measuring the magnetic vector potential with a beam probe has been developed and computer simulations have been performed. Finally our test stand operations have continued to lead to improvements in producing and controlling ion beams

  18. Analytical Chemistry Division annual progress report for period ending December 31, 1982

    International Nuclear Information System (INIS)

    Lyon, W.S.

    1983-05-01

    The Analytical Chemistry Dvision of Oak Ridge National laboratory (ORNL) serves a multitude of functions for a clientele that exists both in and outside ORNL. These functions fall into the following general categories: (1) analytical research, development, and implementation; (2) programmatic research, development, and utilization; and (3) technical support. The Division is organized into five major sections, each of which may carry out any type of work falling in the three categories mentioned above. Chapters 1 through 5 of this report highlight progress within the five sections (analytical methodology, mass and emission spectrometry, radioactive materials, bio/organic analysis, and general and environmental analysis) during the period January 1, 1982 to December 31, 1982. A short summary introduces each chapter to indicate work scope. Information about quality assurance and safety programs is presented in Chapter 6, along with a tabulation of analyses rendered. Publications, oral presentations, professional activities, educational programs, and seminars are cited in Chapters 7 and 8. Approximately 61 articles, 32 proceedings publications and 37 reports have been published, and 107 oral presentations were given during this reporting period

  19. Environmental Sciences Division annual progress report for period ending September 30, 1990

    Energy Technology Data Exchange (ETDEWEB)

    1991-04-01

    The Environmental Sciences Division (ESD) of Oak Ridge National Laboratory (ORNL) conducts research on the environmental aspects of existing and emerging energy systems and applies this information to ensure that technology development and energy use are consistent with national environmental health and safety goals. Offering an interdisciplinary resource of staff and facilities to address complex environmental problems, the division is currently providing technical leadership for major environmental issues of national concern: (1) acidic deposition and related environmental effects, (2) effects of increasing concentrations of atmospheric CO{sub 2} and the resulting climatic changes to ecosystems and natural and physical resources, (3) hazardous chemical and radioactive waste disposal and remediation research and development, and (4) development of commercial biomass energy production systems. This progress report outlines ESD's accomplishments in these and other areas in FY 1990. Individual reports are processed separately for the data bases in the following areas: ecosystem studies; environmental analyses; environmental toxicology; geosciences; technical and administrative support; biofuels feedstock development program; carbon dioxide information analysis and research program; and environmental waste program.

  20. Combined macroscopic and microscopic approach to the fracture of metals. Annual progress report, 1980-1981

    International Nuclear Information System (INIS)

    Asaro, R.J.; Gurland, J.; Needleman, A.; Rice, J.R.

    1981-06-01

    Recent progress was achieved in refining and generalizing the methods previously developed for treating the stable crack growth problem, with particular attention to the approximate asymptotic solution of Rice, Drugan and Sham for stress and deformation fields near the tip of a growing crack. The microstructural aspects of ductile fracture were studied in dual-phase steels and high-strength 4340 steels. Very interesting results were obtained in the work on hydrogen effects in steels. In medium strength steels, the ductility-reducing effect of hydrogen is tentatively attributed to the accumulation of hydrogen at internal interfaces with a resulting loss in the resistance to interfacial separation. Extension of Needleman and Rice's work on the growth of cavities at elevated temperatures to the investigation of the effects of triaxial stressing relates the rate of void growth by grain boundary diffusion and dislocation creep to the triaxiality. It provides a good model to analyze the growth of macro-cracks in polycrystals by the mechanisms of growth and coalescence of micro-voids

  1. Analytical Chemistry Division annual progress report for period ending December 31, 1988

    International Nuclear Information System (INIS)

    1988-05-01

    The Analytical Chemistry Division of Oak Ridge National Laboratory (ORNL) is a large and diversified organization. As such, it serves a multitude of functions for a clientele that exists both in and outside of ORNL. These functions fall into the following general categories: (1) Analytical Research, Development, and Implementation. The division maintains a program to conceptualize, investigate, develop, assess, improve, and implement advanced technology for chemical and physicochemical measurements. Emphasis is on problems and needs identified with ORNL and Department of Energy (DOE) programs; however, attention is also given to advancing the analytical sciences themselves. (2) Programmatic Research, Development, and Utilization. The division carries out a wide variety of chemical work that typically involves analytical research and/or development plus the utilization of analytical capabilities to expedite programmatic interests. (3) Technical Support. The division performs chemical and physicochemical analyses of virtually all types. The Analytical Chemistry Division is organized into four major sections, each of which may carry out any of the three types of work mentioned above. Chapters 1 through 4 of this report highlight progress within the four sections during the period January 1 to December 31, 1988. A brief discussion of the division's role in an especially important environmental program is given in Chapter 5. Information about quality assurance, safety, and training programs is presented in Chapter 6, along with a tabulation of analyses rendered. Publications, oral presentations, professional activities, educational programs, and seminars are cited in Chapters 7 and 8

  2. Measurements and models for hazardous chemical and mixed wastes. 1998 annual progress report

    International Nuclear Information System (INIS)

    Holcomb, C.; Louie, B.; Mullins, M.E.; Outcalt, S.L.; Rogers, T.N.; Watts, L.

    1998-01-01

    'Aqueous waste of various chemical compositions constitutes a significant fraction of the total waste produced by industry in the US. A large quantity of the waste generated by the US chemical process industry is waste water. In addition, the majority of the waste inventory at DoE sites previously used for nuclear weapons production is aqueous waste. Large quantities of additional aqueous waste are expected to be generated during the clean-up of those sites. In order to effectively treat, safely handle, and properly dispose of these wastes, accurate and comprehensive knowledge of basic thermophysical property information is paramount. This knowledge will lead to huge savings by aiding in the design and optimization of treatment and disposal processes. The main objectives of this project are: Develop and validate models that accurately predict the phase equilibria and thermodynamic properties of hazardous aqueous systems necessary for the safe handling and successful design of separation and treatment processes for hazardous chemical and mixed wastes. Accurately measure the phase equilibria and thermodynamic properties of a representative system (water + acetone + isopropyl alcohol + sodium nitrate) over the applicable ranges of temperature, pressure, and composition to provide the pure component, binary, ternary, and quaternary experimental data required for model development. As of May, 1998, nine months into the first year of a three year project, the authors have made significant progress in the database development, have begun testing the models, and have been performance testing the apparatus on the pure components.'

  3. Annual cycles of metabolic rate are genetically determined but can be shifted by phenotypic flexibility

    NARCIS (Netherlands)

    Versteegh, M. A.; Helm, B.; Gwinner, E.; Tieleman, B. I.

    2012-01-01

    Birds have adjusted their life history and physiological traits to the characteristics of the seasonally changing environments they inhabit. Annual cycles in physiology can result from phenotypic flexibility or from variation in its genetic basis. A key physiological trait that shows seasonal

  4. Canada's climate change voluntary challenge and registry program : Suncor Energy Inc. eighth annual progress report

    International Nuclear Information System (INIS)

    2002-10-01

    A corporate profile of Suncor Energy, a Canadian integrated energy company placing the emphasis on the development of the Athabasca oil sands in northern Alberta, is provided. A message from the president reiterates the company's commitment to improving both the environmental and economic performance through innovative policies and strategic management plans. A sustainable approach to climate change has meant an effort toward reducing the emissions of greenhouse gases and improving energy use. Suncor has lowered its greenhouse gas emission intensity by 11 per cent below 1990 levels in 2001. Total reductions of 12.9 million tonnes have been achieved during the period 1990-2001. The total absolute emissions are above 1990 levels, which can be explained by tremendous production growth at Suncor Energy. Suncor has developed a seven-point plan to address the issue of climate change as follows: manage its greenhouse gas emissions, develop renewable sources of energy, invest in environmental and economic research, use domestic and foreign offsets, collaborate with governments and other stakeholder groups on policy development, educate its employees and the public on ways to respond to the risk posed by climate change, and measure and report its progress from that perspective. The document is divided into sections. The first section provides an organization profile, and section two discusses senior management support. In section three, a review of base year methodology and quantification is provided, followed by projection in section four. Target setting is the topic of section five, while section six deals with measures to achieve targets. The results achieved are highlighted in section seven. Education, training and awareness is broached in section eight, and the final section includes the statistical summary. tabs., figs

  5. Analytical Chemistry Division annual progress report for period ending December 31, 1991

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-01-01

    The following sentences highlight some of the technical activities carried out during 1991. They illustrate the diversity of programs and technical work performed within the Analytical Chemistry Division. Our neutron activation analysis laboratory at HFIR was placed into operation during 1991. We have combined inductively coupled plasma mass spectrometry (ICP/MS) with a preparation procedure developed at the Argonne National Laboratory to measure ultra-trace levels of U, Pu, Np, and Am in body fluids, primarily urine. Much progress has been made over the last year in the interfacing of an rf-powered glow discharge source to a double-focusing mass spectrometer. Preliminary experiments using electrospray ionization combined with ion trap mass spectrometry show much promise for the analysis of metals in solution. A secondary ion microprobe has been constructed that permits determination of the distribution of organic compounds less than a monolayer thick on samples as large as 1 cm diameter. Fourier transform mass spectrometry has been demonstrated to be a highly effective tool for the detailed characterization of biopolymers, especially normal and modified oligonucleotides. Much has been accomplished in understanding the fundamentals of quadrupole ion trap mass spectrometry. Work with ITMS instrumentation has led to the development of rapid methods for the detection of trace organics in environmental and physiological samples. A new type of time-of-flight mass spectrometer was designed for use with our positron ionization experiments. Fundamental research on chromatography at high concentrations and on gas-solid adsorption has continued. The preparation of a monograph on the chemistry of environmental tobacco smoke was completed this year.

  6. Surface and borehole electromagnetic imaging of conducting contaminant plumes. 1997 annual progress report

    International Nuclear Information System (INIS)

    Berryman, J.G.

    1997-01-01

    'Electromagnetic induction tomography is a promising new tool for imaging electrical conductivity variations in the earth. The EM source field is produced by induction coil (magnetic dipole) transmitters deployed at the surface or in boreholes. Vertical and horizontal component magnetic field detectors are deployed in other boreholes or on the surface. Sources and receivers are typically deployed in a configuration surrounding the region of interest. The goal of this procedure is to image electrical conductivity variations in the earth, much as x-ray tomography is used to image density variations through cross-sections of the body. Although such EM field techniques have been developed and applied, the algorithms for inverting the magnetic data to produce the desired images of electrical conductivity have not kept pace. One of the main reasons for the lag in the algorithm development has been the fact that the magnetic induction problem is inherently three dimensional: other imaging methods such as x-ray and seismic can make use of two-dimensional approximations that are not too far from reality, but the author does not have this luxury in EM induction tomography. In addition, previous field experiments were conducted at controlled test sites that typically do not have much external noise or extensive surface clutter problems often associated with environmental sites. To use the same field techniques in environments more typical of cleanup sites requires a new set of data processing tools to remove the effects of both noise and clutter. The goal of this project is to join theory and experiment to produce enhanced images of electrically conducting fluids underground, allowing better localization of contaminants and improved planning strategies for the subsequent remediation efforts. After explaining the physical context in more detail, this report will summarize the progress made in the first year of this project: (1) on code development and (2) on field tests of

  7. Environmental analysis of endocrine disrupting effects from hydrocarbon contaminants in the ecosystem. 1998 annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    McLachlan, J.

    1998-06-01

    'The objective of this project is to determine how environmental contaminants, namely hydrocarbons, can act as hormones or anti-hormones (i.e., environmental hormones) in different species present in aquatic ecosystems. Species of particular focus are those which can serve as sentinel species (e.g., amphibians) and, thus, provide early warning signals for more widespread impacts on an ecosystem and its wildlife and human inhabitants. This reports the progress of 1.5 years of a three-year grant awarded to the Tulane/Xavier Center for Bioenvironmental Research (CBR). A growing body of evidence suggests that chemicals in the environment can disrupt the endocrine system of animals (i.e., wildlife and humans) and adversely impact the development of these species. Because of the multitude of known endocrine-disrupting chemicals and the numerous industrial and government sectors producing these chemicals, almost every federal agency has initiated research on the endocrine effects of chemicals relevant to their operations. This study represents the Department of Energy (DOE) Basic Energy Sciences'' only research on the impacts of endocrine-disrupting chemicals. The activities employed by this project to determine these impacts include development of biotechnology screens (in vitro), animal screens (in vivo), and other analyses of aquatic ecosystem biomarkers of exposure. The results from this study can elucidate how chemicals in the environment, including those from DOE activities, can signal (and alter) the development of a number of species in aquatic ecosystems. These signals can have detrimental impacts not only on an organismal level, but also on community, population, and entire ecosystem levels, including humans.'

  8. Environmental analysis of endocrine disrupting effects from hydrocarbon contaminants in the ecosystem. 1998 annual progress report

    International Nuclear Information System (INIS)

    McLachlan, J.

    1998-01-01

    'The objective of this project is to determine how environmental contaminants, namely hydrocarbons, can act as hormones or anti-hormones (i.e., environmental hormones) in different species present in aquatic ecosystems. Species of particular focus are those which can serve as sentinel species (e.g., amphibians) and, thus, provide early warning signals for more widespread impacts on an ecosystem and its wildlife and human inhabitants. This reports the progress of 1.5 years of a three-year grant awarded to the Tulane/Xavier Center for Bioenvironmental Research (CBR). A growing body of evidence suggests that chemicals in the environment can disrupt the endocrine system of animals (i.e., wildlife and humans) and adversely impact the development of these species. Because of the multitude of known endocrine-disrupting chemicals and the numerous industrial and government sectors producing these chemicals, almost every federal agency has initiated research on the endocrine effects of chemicals relevant to their operations. This study represents the Department of Energy (DOE) Basic Energy Sciences'' only research on the impacts of endocrine-disrupting chemicals. The activities employed by this project to determine these impacts include development of biotechnology screens (in vitro), animal screens (in vivo), and other analyses of aquatic ecosystem biomarkers of exposure. The results from this study can elucidate how chemicals in the environment, including those from DOE activities, can signal (and alter) the development of a number of species in aquatic ecosystems. These signals can have detrimental impacts not only on an organismal level, but also on community, population, and entire ecosystem levels, including humans.'

  9. Testing of selected pharmacological agents for capturing waterfowl [Annual Progress Report

    Science.gov (United States)

    Cline, D.R.

    1970-01-01

    The response of game-farm mallards (Frost strain) to seven pharmacological immobilizing agents was evaluated in Phase I of a planned four-phase study. A limited amount of testing was also done with wild mallards. Single dosages were administered to determine the mean effective dose (ED50) and mean lethal dose (LD50), The therapeutic index, or safety factor (LD50/ED50), and palatability were also established. Optimum dosage rates of compounds administered orally on baits were not considered in this phase of the study. Compounds were-administered by intubation and calculated in terms of mg/kg. All except one compound produced narcosis within 5 minutes at the effective dose rate.Immobilization periods for the seven compounds ranged from 7-24 minutes, and recovery periods from 1.0-6.5 hours. Such wide variations in actions of the compounds can be attributed to a compound's rate of absorption, the ease with which it passes the blood-brain barrier, its solubility in tissues, and its rate of metabolism in the liver and kidneys. Length of both the immobilization and recovery periods were extended when dosages were increased. There was no delayed mortality among survivors with any of the seven compounds at either the ED50 or LD50. Females were generally more sensitive to the anesthetizing agents than males. The ED50 for wild mallards was substantially higher than that for the experimental game-farm birds for the two compounds on which this was tested.Tribromoethanol (Avertin of Winthrop Laboratories) satisfied all test criteria an Phase I and will be subjected to more intensive investigation in ensuing tests. Thiopental sodium (Pentothal of Amdal Company) and pentobarbital sodium (Nembutal of Abbott Laboratories) were judged to be marginal. Although their therapeutic indexes were good (5.00), recovery periods were prolonged and toxic convulsions occurred at medium to high dose rates as the LD50 was approached.Alpha-chloralose (Fisher Scientific) proved least promising of

  10. Lake Roosevelt White Sturgeon Recovery Project : Annual Progress Report, January 2003 – March 2004.

    Energy Technology Data Exchange (ETDEWEB)

    Howell, Matthew D.; McLellan, Jason G. [Washington Department of Fish and Wildlife

    2009-07-15

    This report summarizes catch data collected from white sturgeon Acipenser transmontanus in Lake Roosevelt during limited setlining and gill netting activities in the fall of 2003, and documents progress toward development of a U.S. white sturgeon conservation aquaculture program for Lake Roosevelt. From 27-30 October, 42 overnight small mesh gill net sets were made between Marcus and Northport, WA for a total catch of 15 juvenile white sturgeon (275-488 mm FL). All sturgeon captured were of Canadian hatchery origin. These fish had been previously released as sub-yearlings into the Canadian portion (Keenleyside Reach) of the Transboundary Reach of the Columbia River during 2002 and 2003. Most sturgeon (n=14) were caught in the most upstream area sampled (Northport) in low velocity eddy areas. Five fish exhibited pectoral fin deformities (curled or stunted). Growth rates were less than for juvenile sturgeon captured in the Keenleyside Reach but condition factor was similar. Condition factor was also similar to that observed in juvenile sturgeon (ages 1-8) captured in the unimpounded Columbia River below Bonneville Dam between 1987-92. From 10-14 November, 28 overnight setline sets were made in the Roosevelt Reach between the confluence of the Spokane River and Marcus Island for a total catch of 17 white sturgeon (94-213 cm FL). Catch was greatest in the most upstream areas sampled, a distribution similar to that observed during a WDFW setline survey in Lake Roosevelt in 1998. The mean W{sub r} index of 110% for fish captured this year was higher than the mean W{sub r} of 91% for fish captured in 1998. Excellent fish condition hindered surgical examination of gonads as lipid deposits made the ventral body wall very thick and difficult to penetrate with available otoscope specula. Acoustic tags (Vemco model V16 coded pingers, 69 kHz, 48-month life expectancy) were internally applied to 15 fish for subsequent telemetry investigations of seasonal and reproductively

  11. Photocatalytic and chemical oxidation of organic compounds in supercritical carbon dioxide. 1998 annual progress report

    International Nuclear Information System (INIS)

    Blake, D.M.

    1998-01-01

    organic compounds in supercritical carbon dioxide can be achieved. Until recently it was not possible for us to obtain high quality, quantitative kinetic data. The original flow cell used to obtain UV-Visible spectra on the recirculating fluid did not provide quantitative concentration data because the sapphire windows did not have adequate transmission characteristics below about 240 nm. A pair of windows with better transmission properties arrived as this report was being prepared. While waiting for the replacement windows for the flow cell, the concentration of reactants was monitored by withdrawing samples of the fluid stream for gas chromatographic analysis. This allowed progress to be made in determining some of the factors that affected the rates of reaction in a qualitative sense but the results had large error bars due to the difficulty in obtaining reproducible samples from the pressurized system using gas tight syringes. This problem was recently solved by incorporating a gas chromatograph with automatic sampling valves into the flow system. The two on line analytical methods will now result in reliable analytical data that can be used to follow the reaction kinetics and detect and identify reaction intermediates and by-products, if any are formed.'

  12. Savannah River Ecology Laboratory, Annual Technical Progress Report of Ecological Research, June 30, 2002

    International Nuclear Information System (INIS)

    Paul M. Bertsch,

    2002-01-01

    The Savannah River Ecology Laboratory (SREL) is a research unit of The University of Georgia (UGA) and has been conducting ecological research on the Savannah River Site (SRS) near Aiken, South Carolina for 50 years. The overall mission of the Laboratory is to acquire and communicate knowledge of ecological processes and principles. SREL conducts fundamental and applied ecological research, as well as education and outreach programs, under a Cooperative Agreement with the U.S. Department of Energy (DOE). The Laboratory's research mission during the 2002 fiscal year was fulfilled with the publication of 76 journal articles and book chapters by faculty, technical staff, students, and visiting scientists. An additional 50 journal articles have been submitted or are in press. Other noteworthy events took place as faculty members, staff, and graduate students received awards. These are described in the section titled Special Accomplishments of Faculty, Staff, Students, and Administration on page 51. Notable scientific accomplishments include work conducted on contaminant transport, stable isotopes, sandhills ecology, and phytoremediation: (1) A collaborative study between Dr. Tom Hinton at SREL and scientists at SRTC demonstrated the feasibility of using illite clay to sequester 137Cs in sediments along the P and R reactor cooling canal system, where approximately 3, 000 acres of land are contaminated. Overall, the study showed significant decreases in cesium concentrations and bioavailability following the addition of illite with no sign of harm to the ecosystem. While the cesium remains sequestered from the biosphere, its radioactivity decays and the process progresses from contaminant immobilization to remediation. (2) SREL's stable isotope laboratory is now fully functional. Stable isotope distributions in nature can provide important insights into many historical and current environmental processes. Dr. Christopher Romanek is leading SREL's research in this area

  13. Savannah River Ecology Laboratory, Annual Technical Progress Report of Ecological Research, June 30, 2002

    Energy Technology Data Exchange (ETDEWEB)

    Paul M. Bertsch, (Director)

    2002-06-30

    The Savannah River Ecology Laboratory (SREL) is a research unit of The University of Georgia (UGA) and has been conducting ecological research on the Savannah River Site (SRS) near Aiken, South Carolina for 50 years. The overall mission of the Laboratory is to acquire and communicate knowledge of ecological processes and principles. SREL conducts fundamental and applied ecological research, as well as education and outreach programs, under a Cooperative Agreement with the U.S. Department of Energy (DOE). The Laboratory's research mission during the 2002 fiscal year was fulfilled with the publication of 76 journal articles and book chapters by faculty, technical staff, students, and visiting scientists. An additional 50 journal articles have been submitted or are in press. Other noteworthy events took place as faculty members, staff, and graduate students received awards. These are described in the section titled Special Accomplishments of Faculty, Staff, Students, and Administration on page 51. Notable scientific accomplishments include work conducted on contaminant transport, stable isotopes, sandhills ecology, and phytoremediation: (1) A collaborative study between Dr. Tom Hinton at SREL and scientists at SRTC demonstrated the feasibility of using illite clay to sequester 137Cs in sediments along the P and R reactor cooling canal system, where approximately 3,000 acres of land are contaminated. Overall, the study showed significant decreases in cesium concentrations and bioavailability following the addition of illite with no sign of harm to the ecosystem. While the cesium remains sequestered from the biosphere, its radioactivity decays and the process progresses from contaminant immobilization to remediation. (2) SREL's stable isotope laboratory is now fully functional. Stable isotope distributions in nature can provide important insights into many historical and current environmental processes. Dr. Christopher Romanek is leading SREL's research

  14. Progress report on nuclear science and technology in China (Vol.1). Proceedings of academic annual meeting of China Nuclear Society in 2009, No.7--pulse power technology

    International Nuclear Information System (INIS)

    2010-11-01

    Progress report on nuclear science and technology in China (Vol. 1) includes 889 articles which are communicated on the first national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the seventh one, the content is about nuclear electronics, nuclear detecting technology, pulse power technology, nuclear fusion and plasma

  15. Progress report on nuclear science and technology in China (Vol.1). Proceedings of academic annual meeting of China Nuclear Society in 2009, No.5

    International Nuclear Information System (INIS)

    2010-11-01

    Progress report on nuclear science and technology in China (Vol. 1) includes 889 articles which are communicated on the first national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the fifth one, the content is about radiation protection and nuclear chemical industry.

  16. Progress report on nuclear science and technology in China (Vol.1). Proceedings of academic annual meeting of China Nuclear Society in 2009, No.4--nuclear material

    International Nuclear Information System (INIS)

    2010-11-01

    Progress report on nuclear science and technology in China (Vol. 1) includes 889 articles which are communicated on the first national academic annual meeting of China Nuclear Society. There are 10 books totally.This is the fourth one, the content is about nuclear materials, isotope separation, nuclear chemistry and radiological chemistry.

  17. Progress report on nuclear science and technology in China (Vol.1). Proceedings of academic annual meeting of China Nuclear Society in 2009, No.8--isotope

    International Nuclear Information System (INIS)

    2010-11-01

    Progress report on nuclear science and technology in China (Vol. 1) includes 889 articles which are communicated on the first national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the eighth one, the content is about radiation study, radiation technology, isotope and nuclear agriculture

  18. Hypertensive patients exhibit an altered metabolism. A specific metabolite signature in urine is able to predict albuminuria progression.

    Science.gov (United States)

    Gonzalez-Calero, Laura; Martin-Lorenzo, Marta; Martínez, Paula J; Baldan-Martin, Montserrat; Ruiz-Hurtado, Gema; Segura, Julian; de la Cuesta, Fernando; Barderas, Maria G; Ruilope, Luis M; Vivanco, Fernando; Alvarez-Llamas, Gloria

    2016-12-01

    Hypertension (HTN) is increasing in prevalence, and albuminuria is a strong indicator of cardiovascular risk and renal damage progression. Despite blood pressure control with chronic treatment, a relevant subgroup of patients develop albuminuria. However, the biological factors responsible for albuminuria development and progression are underexplored. We aimed to identify key metabolic targets and biological pathways involved in the negative progression of cardiovascular and renal damage in hypertensives undergoing chronic treatment. A series of 1533 patients were followed for 5 years to investigate the evolution of albuminuria. Patients were classified as: (1) patients with persistent normoalbuminuria; (2) patients developing de novo albuminuria; and (3) patients with maintained albuminuria. At the end of follow-up, urine from 30 nonhypertensive subjects (control group) and a representative cohort of 118 patients was collected for metabolomic analysis. Metabolic patterns of interest were identified in a first discovery phase by nuclear magnetic resonance and further confirmed by liquid chromatography-mass spectrometry. Metabolites corresponding to HTN or albuminuria were measured in a prospective study carried out in 35 individuals still in normoalbuminuria, to evaluate their potential as predictors of albuminuria development. Nine metabolites were significantly altered, linking β-alanine metabolism, arginine and proline metabolism, and tricarboxylic acid cycle. The prospective study revealed a panel composed of guanidinoacetate, glutamate, and pantothenate, which was able to predict development of albuminuria. These metabolic signatures open new possibilities in hypertensive therapy and cardiovascular risk control, providing prompt and more efficient intervention, particularly in patients with worse cardiovascular prognosis. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Trends in clinical hemapheresis 1986. Progress report on the 4th annual meeting of the European Society for Hemapheresis.

    Science.gov (United States)

    Nydegger, U E; Vaudaux, P; Castelli, D

    1987-09-01

    After a rather long initial period fraught with difficulties, plasma exchange has become an adjunct to the treatment of numerous diseases, such as hyperviscosity syndrome, where it alleviates disease symptoms, hemophilia due to inhibitors to clotting factor VIII, thrombotic thrombocytopenic purpura, rapidly progressing and Goodpasture glomerulonephritis, myasthenia gravis and Guillain Barré syndrome. In addition, plateletpheresis has also grown from being a procedure of experimental clinical application to one of practical routine importance; at the Berne University Hospital, approximately 25% of all transfused platelets in 1986 were apheresis platelets, a proportion that elsewhere may reach 40%. Despite the successes so far obtained with apheresis, many aspects of this therapy remain to be reconsidered. Improvement of donor-recipient matching and of yield in plateletpheresis, better selection of replacement fluids, and increased donor and patient safety and comfort may further strengthen the value of apheresis in therapeutic protocols. This was the major background for the scientific program of the 4th Annual Meeting of the European Society for Hemapheresis that was assembled to shed light on those aspects of the apheresis field which are still unclear. A total of 31 lectures and 76 individual contributions were debated by 280 participants from Europe and overseas. The present essay is a review of the highlights of this meeting, the main lectures of which were published in Plasma Therapy and Transfusion Technology, vol. 7, 1986.

  20. Reduced FDG-PET brain metabolism and executive function predict clinical progression in elderly healthy subjects

    Directory of Open Access Journals (Sweden)

    Michael Ewers

    2014-01-01

    Full Text Available Brain changes reminiscent of Alzheimer disease (AD have been previously reported in a substantial portion of elderly cognitive healthy (HC subjects. The major aim was to evaluate the accuracy of MRI assessed regional gray matter (GM volume, 18F-fluorodeoxyglucose positron emission tomography (FDG-PET, and neuropsychological test scores to identify those HC subjects who subsequently convert to mild cognitive impairment (MCI or AD dementia. We obtained in 54 healthy control (HC subjects a priori defined region of interest (ROI values of medial temporal and parietal FDG-PET and medial temporal GM volume. In logistic regression analyses, these ROI values were tested together with neuropsychological test scores (free recall, trail making test B (TMT-B as predictors of HC conversion during a clinical follow-up between 3 and 4 years. In voxel-based analyses, FDG-PET and MRI GM maps were compared between HC converters and HC non-converters. Out of the 54 HC subjects, 11 subjects converted to MCI or AD dementia. Lower FDG-PET ROI values were associated with higher likelihood of conversion (p = 0.004, with the area under the curve (AUC yielding 82.0% (95% CI = (95.5%, 68.5%. The GM volume ROI was not a significant predictor (p = 0.07. TMT-B but not the free recall tests were a significant predictor (AUC = 71% (95% CI = 50.4%, 91.7%. For the combination of FDG-PET and TMT-B, the AUC was 93.4% (sensitivity = 82%, specificity = 93%. Voxel-based group comparison showed reduced FDG-PET metabolism within the temporo-parietal and prefrontal cortex in HC converters. In conclusion, medial temporal and-parietal FDG-PET and executive function show a clinically acceptable accuracy for predicting clinical progression in elderly HC subjects.

  1. Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression.

    Science.gov (United States)

    Li, Zhaoyong; Zhang, Huafeng

    2016-01-01

    Metabolic reprogramming is widely observed during cancer development to confer cancer cells the ability to survive and proliferate, even under the stressed, such as nutrient-limiting, conditions. It is famously known that cancer cells favor the "Warburg effect", i.e., the enhanced glycolysis or aerobic glycolysis, even when the ambient oxygen supply is sufficient. In addition, deregulated anabolism/catabolism of fatty acids and amino acids, especially glutamine, serine and glycine, have been identified to function as metabolic regulators in supporting cancer cell growth. Furthermore, extensive crosstalks are being revealed between the deregulated metabolic network and cancer cell signaling. These exciting advancements have inspired new strategies for treating various malignancies by targeting cancer metabolism. Here we review recent findings related to the regulation of glucose, fatty acid and amino acid metabolism, their crosstalk, and relevant cancer therapy strategy.

  2. 1982 - Annual progress report

    International Nuclear Information System (INIS)

    1983-01-01

    This report briefly presents the activities of the laboratory of ionized medium physics during the year 1982: laser-matter interaction and compression of targets by laser; plasma turbulence; high intensity beams of ions and electrons; negative ions produced in plasma [fr

  3. 1982 Annual progress report

    International Nuclear Information System (INIS)

    1983-01-01

    This document briefly presents the works in numerical analysis, statistical and stochastic processes, theoretical mathematical logic (algorithms) realized by the Centre de Mathematiques Appliquees de l'Ecole Polytechnique [fr

  4. Annual progress report

    International Nuclear Information System (INIS)

    Simon, A.

    1979-01-01

    The research topics covered include a study of the nonlinear behavior of the drift cyclotron loss-cone instability in mirror machines and a study of the longer time behavior of the nonlinear O'Neil trapped particle saturation. The saturation amplitude for a single dominant mode near the stability onset boundary was determined for the drift cyclotron loss-cone instability for a variety of mirror-like distributions. The results are in good agreement with computer simulation studies of Cohen and Maron

  5. Annual progress report 1985

    International Nuclear Information System (INIS)

    1985-01-01

    The experimental research program has two major themes -the study of hydromagnetic waves and RF heating using the TORTUS tokamak and the development of diagnostic techniques. Some highlights during 1985 were: the completion of an experiment which shows that antennas used in Alfven wave heating should not have current elements parallel to the magnetic field and that they should be operated at frequencies well below the ion cyclotron frequency - otherwise, the antenna directly excites unwanted Alfven waves in the edge plasma; the use of the scanning submillimetre laser inteferometer to determine the radial profile of the electron density in TORTUS; and the completion of the experimental observation of laser induced fluorescence using the SUPPER II plasma

  6. Annual progress report 1975

    International Nuclear Information System (INIS)

    This report gives a general survey of the activities and research work done in 1975 at Institut de Physique Nucleaire, Orsay. It is divided in 5 parts. The first one is concerned with the Nuclear Physics Division and the research fields are: nuclear reactions, nuclear spectroscopy (heavy ions, on-line analog isobaric states, transfer reactions), hyperfine interactions, exotic nuclei search... The second part is concerned with the work of the High Energy Physics Division and reports the creation in Annecy of the Particle Physics Laboratory (L.A.P.P.). The third one about the Radiochemistry Division reports the research work done in nuclear chemistry (new nuclear species research, fusion, quasi-elastic transfer reactions) and in radiochemistry (cis- and trans-uranium elements, natural superheavy element research). The fourth part is concerned with theoretical research in nuclear physics (nuclear structure, nuclear reactions, weak interactions, intermediate energies) and in particle physics (field theory, gauge theory, chiral symmetry, current algebra, off-shell amplitudes and strong interactions dynamics). The fifth part reports technical research about accelerators, separators, ion sources, semiconductors and the activities of the technical departments of the Institute [fr

  7. Annual progress report 1981

    International Nuclear Information System (INIS)

    1982-01-01

    The most important decision in the life of the Association in 1981 was the final commitment to the Tore Supra programme, a decision which allowed the effective advance to the construction phase at Cadarache. Another general feature of the programme is the growing importance of international collaboration, especially European. The most important in volume concerns the JET and Garching IPP, which continue their already old and well-established relations. Others exist with Sweden, Denmark, the JRC/Ispra Centre, the United Kingdom, and the INTOR and NET projects. The Fontenay aux Roses TFR program is increasingly oriented towards HF heating by ion cyclotron resonance and the HF divertor, and also towards fundamental problems of transport, fluctuations and disruptions. The HF heating at low hydrid resonance will be resumed in Grenoble on the Petula Tokamak which was radically changed and improved, and which was successfully restarted in December 1981. Moreover, the joint Franco-German programme on the Wega Tokamak in Grenoble was stopped at the end of 1981, after having obtained significant results on HF power transmission. The development of ion sources and intense beams continued successfully in Fontenay aux Roses for applications to ASDEX and to JET, and these results will also be invaluable for the Tore Supra project. The theoretical research grouped in a special chapter of the report covers a vast spectrum of investigations, ranging from pure theory to that associated directly with the experimental programme and dealing with a large number of problems [fr

  8. 1982 Annual progress report

    International Nuclear Information System (INIS)

    1983-01-01

    The realization in Cadarache of the big Tokamak with superconducting coils TORE SUPRA is entered in 1982 in the active phase of construction. The most important bargains that have been striken are quoted; the toroidal, cryogenic and poloidal systems have been studied. The experimental programme of TFR Tokamak have been restarted: priority, in physics' programme has been given to ion cyclotron resonance heating. Diagnostics have been, beforehand, improved. ''Pellets'' injection is studied, and principally electron cyclotron resonance. On Tokamak Petula B totally renovated, studies on heating and creation of current in plasma are restarted by the mean of hybrid resonance waves. Works on ion sources and neutral atom injectors are evocated, so are works on sources and negative beams. Theoretical work are very briefly described in this report [fr

  9. Annual progress report 1976

    International Nuclear Information System (INIS)

    This report of the Nuclear Sciences Institute at Grenoble gives a general survey of the scientific and technical work done in 1976. The research areas are: nuclear reactions, gamma spectrometry, polarized neutrons, intermediate energy physics, theoretical physics, accelerators and technical means, the experimental physics at the cyclotron being essentially concerned with three fields: γ spectrometry, giant resonances, mechanisms of heavy ion induced reactions [fr

  10. Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Little, J. B.

    1981-06-01

    Emphasis during the past year has been on studies of the effects of potential promoting agents on radiation transformation, and of transformation by internal radionuclides emitting high LET radiation. We have also carried out a detailed investigation of the dosimetry of our alpha radiation source. Preliminary studies on the mechanisms of radiation transformation have been initiated as described in the previous proposal. Studies on promotion have focused on the effects of: (1) the endogenous steroid hormone 17-..beta..-estradiol; (2) the non-steroidal anti-inflammatory agent indomethacin; (3) the endogenous growth factor called Epidermal Growth Factor (EGF); and (4) Melittin, a stimulator of prostaglandins synthesis.

  11. Annual Research Progress Report.

    Science.gov (United States)

    1979-09-30

    completed in the study of the effects of exercise on the strength of the anterior cruciate ligaments on rats. Statistical analyses were carried out, by...the soleus muscle; the heart, psoas , and quadriceps were unaffected. Exercise increased myoglobin only in the quadriceps and soleus muscles. These data...changes were seen only in the soleus muscle. Other muscles, including the heart, psoas , and quadriceps were unaffected by either exercise or diet. Both

  12. Annual progress report

    International Nuclear Information System (INIS)

    Simon, A.

    1975-01-01

    Considerable success has been achieved this year in research aimed at extending the asymptotic threshold nonlinear theory to plasmas governed by the Vlasov equation and in a group of linear studies concerned with drift instabilities in sheared magnetic fields. The nonlinear results are general and have been applied to the bump-on-tail instability and to the collisionless drift and the dissipative trapped electron instability in unsheared fields. The linear studies have dealt with the effects of resonant electrons, finite collisionality, finite-beta, neoclassical modifications and ion gyro-motion on trapped electron instabilities in sheared magnetic fields

  13. 1982. Annual progress report

    International Nuclear Information System (INIS)

    1983-01-01

    The research programs of the laboratory are presented: interactions of neutrinos, quark fusion in hadronic interactions, proton instability, development of instrumentation for experiments at the LEP [fr

  14. Annual progress report 1975

    International Nuclear Information System (INIS)

    This report of the Nuclear Sciences Institute at Grenoble gives a general survey of the scientific and technical work done in 1975. The research areas are: nuclear reactions, gamma spectroscopy, polarized neutrons, intermediate energy physics, theoretical physics, accelerators and technical means [fr

  15. Annual progress report

    International Nuclear Information System (INIS)

    Wattenberg, A.; Simmons, R.O.

    1980-06-01

    During the present year, a major effort was put into developing the Mark III detector to be used with the e + e - colliding beams at SPEAR. Data from previous experiments at Fermilab using both neutral and charged particle beams were analyzed, and an approximately seven-month run with the photon beam on hydrogen and deuterium targets was performed. Apparatus for the forthcoming series of experiments using a proton beam with the Chicago Cyclotron Facility at Fermilab was developed and built. The main motivation for all the above experiments was to study the production and decay of states containing charmed quarks. During the coming year a major effort will continue at SLAC with the completion of the Mark III detector and its use in taking initial data. It is anticipated that several years of data taking with the Mark III will be required to obtain a statistically significant number of events of interest. At Fermilab an experiment using a proton beam with the Chicago Cyclotron Facility and a neutron beam in the broad band neutral beam facility will be performed. The data from the previous photoproduction run will be analyzed. In future years at Fermilab, experiments will be performed at increasingly higher energies as they become available. One of the motivations is the possible production of the (weak) intermediate vector bosons by colliding proton and anti-proton beams. For this purpose, a detector for the colliding beams is being developed, as is the so-called FASTBUS system. The scope of the program is best summarized by listing major accomplishments during the present year and the major parts of the program for the coming year. Being administrative in nature, this report contains insignificant amounts of data

  16. 1983 Annual progress report

    International Nuclear Information System (INIS)

    1984-05-01

    This report is concerned with the whole activities of the LETI (Laboratoire d'Electronique et de Technologie de l'Informatique) during 1983. They defined three sections wich are ''materials'', ''electronic components'' and the one called ''instrumentation and systems''. Among the magnetic materials, materials for magnetic bubble memories are concerned. Among semi-conductor materials, first, crystals of gallium arsenide and germanium are peculiarly studied; then researches on crystal growth processes aim at deposition of zinc or cadmium sulfide thin layers in aqueous solutions; and, finally, piezoelectric material researches consisted essentially in developing fabrication processes of lithium niobiate. Materials for infra-red devices are also studied together with materials related to optical microstructures (LNA, MgF 2 , LiYF 4 ). The section ''Components'' comprises silicium microelectronics (ionic implantation techniques, MOS systems, etc), the magnetic bubble memories, the components related to integrated circuits for infrared imaging or to Josephson effect devices. Display, sensors, optical telecommunications, wiring terminations are also concerned. Physics and medicine instrumentation (magnetometry, time-of-flight positon tomography, X-ray tomography, NMR spectrometry in-vivo), robotics and technology of acquisition and processing of images (in view of an automatic control) are activities of the last section [fr

  17. Annual progress report 1980

    International Nuclear Information System (INIS)

    1980-01-01

    Through the years, the research and development efforts of PAEC have been geared to promoting the peaceful utilization of atomic energy and ensuring public health and safety in the use of atomic energy facilities. Comprehensively discussed are the research projects, activities, supportive services and other areas of accomplishments of PAEC. These are generally divided into categories under I. Research and Development: (a) Food, Agriculture (b) Nuclear Fuels and Power Systems Technology (c) Public Health and Nutrition Research (d) Supportive basic research and (e) Environmental Surveillance; II. Nuclear Safety: (a) Radiological Protection and safety (b) Nuclear Licensing and Safeguards; III. Supportive Technology such as: (a) Radioisotope Production and Development (b) Nuclear Manpower Development (c) Nuclear Information and Public acceptance (d) Program Management (e) Nuclear Regulation. A listing of projects and annotations are included under each category. (RTD)

  18. Annual progress report

    International Nuclear Information System (INIS)

    Little, J.B.

    1981-01-01

    Emphasis during the past year has been on studies of the effects of potential promoting agents on radiation transformation, and of transformation by internal radionuclides emitting high LET radiation. We have also carried out a detailed investigation of the dosimetry of our alpha radiation source. Preliminary studies on the mechanisms of radiation transformation have been initiated as described in the previous proposal. Studies on promotion have focused on the effects of: (1) the endogenous steroid hormone 17-β-estradiol; (2) the non-steroidal anti-inflammatory agent indomethacin; (3) the endogenous growth factor called Epidermal Growth Factor (EGF); and (4) Melittin, a stimulator of prostaglandins synthesis

  19. Clinical Cancer Advances 2018: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology.

    Science.gov (United States)

    Heymach, John; Krilov, Lada; Alberg, Anthony; Baxter, Nancy; Chang, Susan Marina; Corcoran, Ryan; Dale, William; DeMichele, Angela; Magid Diefenbach, Catherine S; Dreicer, Robert; Epstein, Andrew S; Gillison, Maura L; Graham, David L; Jones, Joshua; Ko, Andrew H; Lopez, Ana Maria; Maki, Robert G; Rodriguez-Galindo, Carlos; Schilsky, Richard L; Sznol, Mario; Westin, Shannon Neville; Burstein, Harold

    2018-04-01

    A MESSAGE FROM ASCO'S PRESIDENT I remember when ASCO first conceived of publishing an annual report on the most transformative research occurring in cancer care. Thirteen reports later, the progress we have chronicled is remarkable, and this year is no different. The research featured in ASCO's Clinical Cancer Advances 2018 report underscores the impressive gains in our understanding of cancer and in our ability to tailor treatments to tumors' genetic makeup. The ASCO 2018 Advance of the Year, adoptive cell immunotherapy, allows clinicians to genetically reprogram patients' own immune cells to find and attack cancer cells throughout the body. Chimeric antigen receptor (CAR) T-cell therapy-a type of adoptive cell immunotherapy-has led to remarkable results in young patients with acute lymphoblastic leukemia (ALL) and in adults with lymphoma and multiple myeloma. Researchers are also exploring this approach in other types of cancer. This advance would not be possible without robust federal investment in cancer research. The first clinical trial of CAR T-cell therapy in children with ALL was funded, in part, by grants from the National Cancer Institute (NCI), and researchers at the NCI Center for Cancer Research were the first to report on possible CAR T-cell therapy for multiple myeloma. These discoveries follow decades of prior research on immunology and cancer biology, much of which was supported by federal dollars. In fact, many advances that are highlighted in the 2018 Clinical Cancer Advances report were made possible thanks to our nation's support for biomedical research. Funding from the US National Institutes of Health and the NCI helps researchers pursue critical patient care questions and addresses vital, unmet needs that private industry has little incentive to take on. Federally supported cancer research generates the biomedical innovations that fuel the development and availability of new and improved treatments for patients. We need sustained federal

  20. Annual report on reactor safety research projects sponsored by the Ministry of Economics and Labour of the Federal Republic of Germany. Reporting period 2003. Progress report

    International Nuclear Information System (INIS)

    2003-01-01

    The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, by order of the BMWi, continuously issues information on the status of the investigations into the safety of nuclear power plants by publishing semi-annual and annual progress reports within the series of GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work and are published by the Research Management Division of GRS within the framework of general information on the progress in reactor safety research. The compilation of the reports is classified according to general topics related to reactor safety research. Further, use is made of the classification system ''Joint Safety Research Index'' of the CEC (commission of the european communities). The reports are arranged in sequence of their project numbers

  1. Annual report on reactor safety research projects sponsored by the Ministry of Economics and Labour of the Federal Republic of Germany. Reporting period 2002. 2. progress report

    International Nuclear Information System (INIS)

    The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, by order of the BMWi, continuously issues information on the status of the investigations into the safety of nuclear power plants by publishing semi-annual and annual progress reports within the series of GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work and are published by the Research Management Division of GRS within the framework of general information on the progress in reactor safety research. The compilation of the reports is classified according to general topics related to reactor safety research. Further, use is made of the classification system ''Joint Safety Research Index'' of the CEC (commission of the european communities). The reports are arranged in sequence of their project numbers. (orig.) [de

  2. The Community's research and development programme on radioactive waste management and storage. Shared cost action. Annual progress report 1988. Volume 2

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    Third annual progress report of the European Community's 1985-89 programme of research and development on radioactive waste management and disposal, carried out by public organizations and private firms in the Community under cost-sharing contracts with the Commission of the European Communities. This report describes the work to be carried out under research contracts already concluded before the end of 1988, as well as the work performed and the results obtained so far

  3. The Community's research and development programme on radioactive waste management and storage. Shared cost action. Annual progress report 1988. Volume 1

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    Third annual progress report of the European Community's 1985-89 programme of research and development on radioactive waste management and disposal, carried out by public organizations and private firms in the Community under cost-sharing contracts with the Commission of the European Communities. This report describes the work to be carried out under research contracts already concluded before the end of 1988, as well as the work performed and the results obtained so far

  4. 2001 Gordon Research Conference on Archaea: Ecology [sic], Metabolism. Final progress report [agenda and attendee list

    Energy Technology Data Exchange (ETDEWEB)

    Daniels, Charles

    2001-08-10

    The Gordon Research Conference on Archaea: Ecology, Metabolism [and Molecular Biology] was held at Proctor Academy, Andover, New Hampshire, August 5-10, 2001. The conference was attended by 135 participants. The attendees represented the spectrum of endeavor in this field, coming from academia, industry, and government laboratories, and included US and foreign scientists, senior researchers, young investigators, and students. Emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate discussion about the key issues in the field today. Session topics included the following: Ecology and genetic elements; Genomics and evolution; Ecology, genomes and gene regulation; Replication and recombination; Chromatin and transcription; Gene regulation; Post-transcription processing; Biochemistry and metabolism; Proteomics and protein structure; Metabolism and physiology. The featured speaker addressed the topic: ''Archaeal viruses, witnesses of prebiotic evolution?''

  5. Progress of succinic acid production from renewable resources: Metabolic and fermentative strategies.

    Science.gov (United States)

    Jiang, Min; Ma, Jiangfeng; Wu, Mingke; Liu, Rongming; Liang, Liya; Xin, Fengxue; Zhang, Wenming; Jia, Honghua; Dong, Weiliang

    2017-12-01

    Succinic acid is a four-carbon dicarboxylic acid, which has attracted much interest due to its abroad usage as a precursor of many industrially important chemicals in the food, chemicals, and pharmaceutical industries. Facing the shortage of crude oil supply and demand of sustainable development, biological production of succinic acid from renewable resources has become a topic of worldwide interest. In recent decades, robust producing strain selection, metabolic engineering of model strains, and process optimization for succinic acid production have been developed. This review provides an overview of succinic acid producers and cultivation technology, highlight some of the successful metabolic engineering approaches. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Physiology and genetics of metabolic flux control in Zymomonas mobilis. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Conway, T.

    1992-08-01

    This work seeks to understand the role of gene expression in regulating glycolytic enzyme synthesis in a balance that allows proper glycoltic flux control. The seven genes targeted for study in this laboratory have been cloned and sequenced, and molecular details of regulation have been investigated. Clear that glycolytic enzyme synthesis is coordinated to prevent the build up of toxic metabolic intermediates. The genetic mechanisms responsible for regulating balanced expression of the EntnerDoudoroff and glycolytic genes in Z. mobilis are beginning to be understood. Several layers of genetic control, perhaps in a hierarchal arrangement act in concert to determine the relative abundance of the glycolytic enzymes. These genetic controls involve differential translational efficiency, highly conserved promoter sequences, transcription factors, differential mRNA stabilities, and nucleolytic mRNA processing. The serendipitous cloning of the glucose facilitator, glf, as a result of linkage to several other genes of interest will have a significant impact on the study of Z. mobilis metabolism. The glucose facilitator is being characterized in a genetically reconstituted system in E. coli. Molecular genetic studies indicate that the ratio of glf expression to that of glk, zmf, and edd is carefully regulated, and suggests a critical role in metabolic control. Regulation of glycolytic gene expression is now sufficiently well understood to allow use of the glycolytic genes as tools to manipulate specified enzyme levels for the purpose of analyzing metabolic flux control. The critical genes have been subcloned for stable expression in Z. mobilis and placed under control of a regulated promoter system involving the tac promoter, the lacI repressor, and gene induction in by IPTG. HPLC methods have been developed that allow quantitation of virtually all of the metabolic intermediates in the cell pool.

  7. Technical progress report. Private sector initiatives between the United States and Japan. January 1989 - December 1989; ANNUAL

    International Nuclear Information System (INIS)

    1990-01-01

    This annual report for calendar year 1989 describes the efforts performed under the Private Sector Initiatives contract. The report also describes those efforts that have continued with private funding after being initiated under this contract

  8. Technical progress report. Private sector initiatives between the United States and Japan. January 1991 - December 1991; ANNUAL

    International Nuclear Information System (INIS)

    1993-01-01

    This annual report for calendar year 1991 describes the efforts performed under the Private Sector Initiatives contract. The report also describes those efforts that have continued with private funding after being initiated under this contract

  9. Significance of Selective Predation and Development of Prey Protection Measures for Juvenile Salmonids in the Columbia and Snake River Reservoirs: Annual Progress Report, February 1991-February 1992.

    Energy Technology Data Exchange (ETDEWEB)

    Poe, Thomas P.

    1992-12-31

    This document is the 1991 annual report of progress for the Bonneville Power Administration (BPA) research Project conducted by the US Fish and Wildlife Service (FWS). Our approach was to present the progress achieved during 1991 in a series of separate reports for each major project task. Each report is prepared in the format of a scientific paper and is able to stand alone, whatever the state of progress or completion. This project has two major goals. One is to understand the significance of selective predation and prey vulnerability by determining if substandard juvenile salmonids (dead, injured, stressed, diseased, or naive) are more vulnerable to predation by northern squawfish, than standard or normal juvenile salmonids. The second goal is to develop and test prey protection measures to control predation on juvenile salmonids by reducing predator-smolt encounters or predator capture efficiency.

  10. Metabolic Disturbances in the Striatum and Substantia Nigra in the Onset and Progression of MPTP-Induced Parkinsonism Model.

    Science.gov (United States)

    Lu, Yi; Zhang, Xiaoxia; Zhao, Liangcai; Yang, Changwei; Pan, Linlin; Li, Chen; Liu, Kun; Bai, Guanghui; Gao, Hongchang; Yan, Zhihan

    2018-01-01

    Metabolic confusion has been linked to the pathogenesis of Parkinson's disease (PD), while the dynamic changes associated with the onset and progression of PD remain unclear. Herein, dynamic changes in metabolites were detected from the initiation to the development of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced Parkinsonism model to elucidate its potential metabolic mechanism. Ex vivo 1 H nuclear magnetic resonance (NMR) spectroscopy was used to measure metabolite changes in the striatum and substantia nigra (SN) of mice at 1, 7, and 21 days after injection of MPTP. Metabolomic analysis revealed a clear separation of the overall metabolites between PD and control mice at different time points. Glutamate (Glu) in the striatum was significantly elevated at induction PD day 1 mice, which persisted to day 21. N-acetylaspartate (NAA) increased in the striatum of induction PD mice on days 1 and 7, but no significant difference was found in striatum on day 21. Myo-Inositol (mI) and taurine (Tau) were also disturbed in the striatum in induction PD day 1 mice. Additionally, key enzymes in the glutamate-glutamine cycle were significantly increased in PD mice. These findings suggest that neuron loss and motor function impairment in induction PD mice may be linked to overactive glutamate-glutamine cycle and altered membrane metabolism.

  11. Prospects and progress in the production of valuable carotenoids: Insights from metabolic engineering, synthetic biology, and computational approaches.

    Science.gov (United States)

    Sankari, Mohan; Rao, Priya Rajendra; Hemachandran, Hridya; Pullela, Phani Kumar; Doss C, George Priya; Tayubi, Iftikhar Aslam; Subramanian, Babu; Gothandam, K M; Singh, Pooja; Ramamoorthy, Siva

    2018-01-20

    Carotenoids are isoprenoid pigments synthesized exclusively by plants and microorganisms and play critical roles in light harvesting, photoprotection, attracting pollinators and phytohormone production. In recent years, carotenoids have been used for their health benefits due to their high antioxidant activity and are extensively utilized in food, pharmaceutical, and nutraceutical industries. Regulation of carotenoid biosynthesis occurs throughout the life cycle of plants, with vibrant changes in composition based on developmental needs and responses to external environmental stimuli. With advancements in metabolic engineering techniques, there has been tremendous progress in the production of industrially valuable secondary metabolites such as carotenoids. Application of metabolic engineering and synthetic biology has become essential for the successful and improved production of carotenoids. Synthetic biology is an emerging discipline; metabolic engineering approaches may provide insights into novel ideas for biosynthetic pathways. In this review, we discuss the current knowledge on carotenoid biosynthetic pathways and genetic engineering of carotenoids to improve their nutritional value. In addition, we investigated synthetic biological approaches for the production of carotenoids. Theoretical biology approaches that may aid in understanding the biological sciences are discussed in this review. A combination of theoretical knowledge and experimental strategies may improve the production of industrially relevant secondary metabolites. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. The Correlation of PPARα Activity and Cardiomyocyte Metabolism and Structure in Idiopathic Dilated Cardiomyopathy during Heart Failure Progression

    Directory of Open Access Journals (Sweden)

    E. Czarnowska

    2016-01-01

    Full Text Available This study aimed to define relationship between PPARα expression and metabolic-structural characteristics during HF progression in hearts with DCM phenotype. Tissue endomyocardial biopsy samples divided into three groups according to LVEF ((I 45–50%, n=10; (II 30–40%, n=15; (III 60%, n=6 were investigated. The PPARα mRNA expression in the failing hearts was low in Group (I, high in Group (II, and comparable to that of the control in Group (III. There were analogous changes in the expression of FAT/CD36 and CPT-1 mRNA in contrast to continuous overexpression of GLUT-4 mRNA and significant increase of PDK-4 mRNA in Group (II. In addition, significant structural changes of cardiomyocytes with glycogen accumulation were accompanied by increased expression of PPARα. For the entire study population with HF levels of FAT/CD36 mRNA showed a strong tendency of negative correlation with LVEF. In conclusion, PPARα elevated levels may be a direct cause of adverse remodeling, both metabolic and structural. Thus, there is limited time window for therapy modulating cardiac metabolism and protecting cardiomyocyte structure in failing heart.

  13. Studies in iodine metabolism: monitoring of animal thyroids. Progress report, 1984-1985

    International Nuclear Information System (INIS)

    Van Middlesworth, L.

    1986-01-01

    This progress report briefly summarizes the counting and re-counting of domestic or wild animal thyroids from the United Kingdom, Federal Republic of Germany, the reservation of the Savannah River Plant, or from the DOE reservation at Oak Ridge. The possible effect that a mycotoxin may have an iodine deficiency was investigated. 3 refs., 3 figs., 4 tabs. (DT)

  14. 18F-FDG PET/CT in solitary plasmacytoma: metabolic behavior and progression to multiple myeloma

    Energy Technology Data Exchange (ETDEWEB)

    Albano, Domenico; Bosio, Giovanni [Spedali Civili di Brescia, Nuclear Medicine, Brescia (Italy); Treglia, Giorgio [Oncology Institute of Southern Switzerland, Department of Nuclear Medicine and PET/CT Center, Bellinzona (Switzerland); Giubbini, Raffaele; Bertagna, Francesco [University of Brescia and Spedali Civili Brescia, Nuclear Medicine, Brescia (Italy)

    2018-01-15

    Solitary plasmacytoma (SP) is a rare plasma-cell neoplasm, which can develop both in skeletal and/or soft tissue and frequently progresses to multiple myeloma (MM). Our aim was to study the metabolic behavior of SP and the role of 18F-FDG-PET/CT in predicting progression to MM. Sixty-two patients with SP who underwent 18F-FDG-PET/CT before any treatment were included. PET images were qualitatively and semiquantitatively analyzed by measuring the maximum standardized uptake value body weight (SUVbw), lean body mass (SUVlbm), body surface area (SUVbsa), metabolic tumor volume (MTV), total lesion glycolysis (TLG) and compared with age, sex, site of primary disease, and tumor size. Fifty-one patients had positive 18F-FDG-PET/CT (average SUVbw was 8.3 ± 4.7; SUVlbm 5.8 ± 2.6; SUVbsa 2 ± 1; MTV 45.4 ± 37; TLG 227 ± 114); the remaining 11 were not 18F-FDG-avid. Tumor size was significantly higher in patients avid lesions compared to FDG not avid; no other features are associated with FDG-avidity. Progression to MM occurred in 29 patients with an average of 18.3 months; MM was more likely to develop in patients with bone plasmacytoma and in patients with 18F-FDG avid lesion. Time to transformation in MM (TTMM) was significantly shorter in patients with osseous SP, in 18F-FDG avid lesion, for SUVlbm > 5.2 and SUVbsa > 1.7. 18F-FDG pathological uptake in SP occurred in most cases, being independently associated with tumor size. PET/CT seemed to be correlated to a higher risk of transformation in MM, in particular for 18F-FDG avid plasmacytoma and SBP. Among semiquantitative features, SUVlbm > 5.2 and SUVbsa > 1.7 were significantly correlated with TTMM. (orig.)

  15. Apple Peel Supplemented Diet Reduces Parameters of Metabolic Syndrome and Atherogenic Progression in ApoE−/− Mice

    Directory of Open Access Journals (Sweden)

    Jaime Gonzalez

    2015-01-01

    Full Text Available Cardiovascular Diseases (CVD represent about 30% of all causes of death worldwide. The development of CVD is related in many cases with the previous existence of metabolic syndrome (MS. It is known that apple consumption has a cardiovascular protecting effect, containing phenolic compounds with antioxidant effect, which are concentrated in the fruit peel. The objective of this study was to test the effect of apple peel consumption in a murine model of MS and apoE−/− mice. Apple supplemented diets reduced the biochemical parameters (glycaemia, total cholesterol, HDL-cholesterol, LDL-cholesterol, ureic nitrogen, triglycerides, insulin, and asymmetric dimethylarginine (ADMA of MS model in CF1 mice significantly. The model apoE−/− mouse was used to evaluate the capacity of the apple peel to revert the progression of the atherogenesis. FD with HAP reverts cholesterol significantly and slows down the progression of the plate diminishing the cholesterol accumulation area. With these results, it can be concluded that the consumption of apple peel reduces several MS parameters and the atherogenic progression in mice.

  16. PNPLA3, a genetic marker of progressive liver disease, still hiding its metabolic function?

    Science.gov (United States)

    Dubuquoy, Céline; Burnol, Anne-Françoise; Moldes, Marthe

    2013-02-01

    Non-alcoholic fatty liver disease (NAFLD) is an emerging epidemic disease. It represents a large spectrum of liver diseases, and affects both adults and children. The etiology of NAFLD is multifactorial. Indeed, several events such as caloric imbalance including sedentary lifestyle, obesity and/or a predisposing genetic background are key players in the increasing risk for NAFLD development and its progression. Recently, a sequence variation within the gene encoding for patatin-like phospholipase containing 3 (PNPLA3, rs738409) was found to modulate steatosis, inflammation and fibrosis in NAFLD. It was also demonstrated as a novel genetic marker associated with progressive ALD (alcoholic liver disease). In this mini-review, we summarize the current knowledge on (i) PNPLA3 variant(s) in the pathogenesis of liver diseases, and (ii) PNPLA3 gene regulation and potential function in liver. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  17. Limited brain metabolism changes differentiate between the progression and clearance of rabies virus.

    Directory of Open Access Journals (Sweden)

    Keith Schutsky

    Full Text Available Central nervous system (CNS metabolic profiles were examined from rabies virus (RABV-infected mice that were either mock-treated or received post-exposure treatment (PET with a single dose of the live recombinant RABV vaccine TriGAS. CNS tissue harvested from mock-treated mice at middle and late stage infection revealed numerous changes in energy metabolites, neurotransmitters and stress hormones that correlated with replication levels of viral RNA. Although the large majority of these metabolic changes were completely absent in the brains of TriGAS-treated mice most likely due to the strong reduction in virus spread, TriGAS treatment resulted in the up-regulation of the expression of carnitine and several acylcarnitines, suggesting that these compounds are neuroprotective. The most striking change seen in mock-treated RABV-infected mice was a dramatic increase in brain and serum corticosterone levels, with the later becoming elevated before clinical signs or loss of body weight occurred. We speculate that the rise in corticosterone is part of a strategy of RABV to block the induction of immune responses that would otherwise interfere with its spread. In support of this concept, we show that pharmacological intervention to inhibit corticosterone biosynthesis, in the absence of vaccine treatment, significantly reduces the pathogenicity of RABV. Our results suggest that widespread metabolic changes, including hypothalamic-pituitary-adrenal axis activation, contribute to the pathogenesis of RABV and that preventing these alterations early in infection with PET or pharmacological blockade helps protect brain homeostasis, thereby reducing disease mortality.

  18. Metabolomics insights into activated redox signaling and lipid metabolism dysfunction in chronic kidney disease progression

    Directory of Open Access Journals (Sweden)

    Hua Chen

    2016-12-01

    Full Text Available Early detection is critical in prevention and treatment of kidney disease. However currently clinical laboratory and histopathological tests do not provide region-specific and accurate biomarkers for early detection of kidney disease. The present study was conducted to identify sensitive biomarkers for early detection and progression of tubulo-interstitial nephropathy in aristolochic acid I-induced rats at weeks 4, 8 and 12. Biomarkers were validated using aristolochic acid nephropathy (AAN rats at week 24, adenine-induced chronic kidney disease (CKD rats and CKD patients. Compared with control rats, AAN rats showed anemia, increased serum urea and creatinine, progressive renal interstitial fibrosis, activation of nuclear factor-kappa B, and up-regulation of pro-inflammatory, pro-oxidant, and pro-fibrotic proteins at weeks 8 and 12. However, no significant difference was found at week 4. Metabolomics identified 12-ketodeoxycholic acid, taurochenodesoxycholic acid, LPC(15:0 and docosahexaenoic acid as biomarkers for early detection of tubulo-interstitial nephropathy. With prolonging aristolochic acid I exposure, LPE(20:2, cholic acid, chenodeoxycholic acid and LPC(17:0 were identified as biomarkers for progression from early to advanced AAN and lysoPE(22:5, indoxyl sulfate, uric acid and creatinine as biomarkers of advanced AAN. These biomarkers were reversed by treatment of irbesartan and ergone in AAN rats at week 24 and adenine-induced CKD rats. In addition, these biomarkers were also reversed by irbesartan treatment in CKD patients.

  19. Hood River and Pelton Ladder monitoring and evaluation project and Hood River fish habitat project : annual progress report 1999-2000.; ANNUAL

    International Nuclear Information System (INIS)

    Lambert, Michael B.; McCanna, Joseph P.; Jennings, Mick

    2001-01-01

    The Hood River subbasin is home to four species of anadromous salmonids: chinook salmon (Oncorhynchus tshawytscha), coho salmon (Oncorhynchus kisutch), steelhead (Oncorhynchus mykiss), and sea run cutthroat trout (Salmo clarki). Indigenous spring chinook salmon were extirpated during the late 1960's. The naturally spawning spring chinook salmon currently present in the subbasin are progeny of Deschutes stock. Historically, the Hood River subbasin hatchery steelhead program utilized out-of-basin stocks for many years. Indigenous stocks of summer and winter steelhead were listed in March 1998 by National Marine Fisheries Service (NMFS) under the Endangered Species Act (ESA) as a ''Threatened'' Species along with similar genetically similar steelhead in the Lower Columbia Basin. This annual report summarizes work for two consecutive contract periods: the fiscal year (FY) 1999 contract period was 1 October, 1998 through 30 September, 1999 and 1 October, 1999 through 30 September, 2000 for FY 2000. Work implemented during FY 1999 and FY 2000 included (1) acclimation of hatchery spring chinook salmon and hatchery summer and winter steelhead smolts, (2) spring chinook salmon spawning ground surveys on the West Fork Hood River (3) genetic analysis of steelhead and cutthroat[contractual service with the ODFW], (4) Hood River water temperature studies, (5) Oak Springs Hatchery (OSH) and Round Butte Hatchery (RBH) coded-wire tagging and clipping evaluation, (6) preparation of the Hood River Watershed Assessment (Coccoli et al., December 1999) and the Fish Habitat Protection, Restoration, and Monitoring Plan (Coccoli et al., February 2000), (7) project implementation of early action habitat protection and restoration projects, (8) Pelton Ladder evaluation studies, (9) management oversight and guidance to BPA and ODFW engineering on HRPP facilities, and (10) preparation of an annual report summarizing project objectives for FY 1999 and FY 2000

  20. Fusion plasma theory. Task I. Magnetic confinement fusion plasma theory. Annual progress report, January 1, 1982-December 31, 1982

    International Nuclear Information System (INIS)

    Callen, J.D.

    1982-08-01

    The research on this contract over the past year has concentrated on some key tandem mirror confinement and heating issues (barrier trapping current, rf heating, low mode number stability) and on developing a comprehensive neoclassical transport theory for nonaxisymmetric toroidal plasmas (e.g., stellarators). Progress in these and some other miscellaneous areas are summarized briefly in this progress report

  1. Annual report on reactor safety research projects sponsored by the Ministry of Economics and Labour of the Federal Republic of Germany. Reporting period 2004. Progress report

    International Nuclear Information System (INIS)

    2004-01-01

    Within its competence for energy research, the Bundesministerium fuer Wirtschaft und Technology (BMWi) (Federal Ministry of Economics and Technology) sponsors investigations into the safety of nuclear power plants. The objective of these investigations is to provide fundamental knowledge, procedures and methods to contribute to realistic safety assessments of nuclear installations, to the further development of safety technology and to make use of the potential of innovative safety-related approaches. The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, by order of the BMWi, continuously issues information on the status of such investigations by publishing semi-annual and annual progress reports within the series of GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work and are published by the Research Management Division of GRS within the framework of general information on the progress in reactor safety research. The compilation of the reports is classified according to general topics related to reactor safety research. Further, use is made of the classification system 'Joint Safety Research Index' of the CEC (Commission of the European Communities). The reports are arranged in sequence of their project numbers. It has to be pointed out that the authors of the reports are responsible for the contents of this compilation. The BMWi does not take any responsibility for the correctness, exactness and completeness of the information nor for the observance of private claims of third parties. (orig.)

  2. Annual report on reactor safety research projects sponsored by the Ministry of Economics and Labour of the Federal Republic of Germany. Reporting period 2004. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    Within its competence for energy research, the Bundesministerium fuer Wirtschaft und Technology (BMWi) (Federal Ministry of Economics and Technology) sponsors investigations into the safety of nuclear power plants. The objective of these investigations is to provide fundamental knowledge, procedures and methods to contribute to realistic safety assessments of nuclear installations, to the further development of safety technology and to make use of the potential of innovative safety-related approaches. The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, by order of the BMWi, continuously issues information on the status of such investigations by publishing semi-annual and annual progress reports within the series of GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work and are published by the Research Management Division of GRS within the framework of general information on the progress in reactor safety research. The compilation of the reports is classified according to general topics related to reactor safety research. Further, use is made of the classification system 'Joint Safety Research Index' of the CEC (Commission of the European Communities). The reports are arranged in sequence of their project numbers. It has to be pointed out that the authors of the reports are responsible for the contents of this compilation. The BMWi does not take any responsibility for the correctness, exactness and completeness of the information nor for the observance of private claims of third parties. (orig.)

  3. 1993 Annual progress report for subsidiary agreement No. 2 (1991--1996) between AECL and US/DOE for a radioactive waste management technical co-operative program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-12-31

    A coordinated research program on radioactive waste disposal is being carried out by the Atomic Energy of Canada Limited and the US Department of Energy. This annual report describes progress in the following eight studies: Fundamental materials investigations; In-situ stress determination; Development of a spent fuel dissolution model; Large block tracer test--Experimental testing of retardation models; Laboratory and field tests of in-situ hydrochemical tools; Cigar Lake--Analogue study, actinide and fission product geochemistry; Performance assessment technology exchange; and Development of multiple-well hydraulic test and field tracer test methods.

  4. Progressive hyperpigmentation in a Taiwanese child due to an inborn error of vitamin B12 metabolism (cblJ).

    Science.gov (United States)

    Takeichi, T; Hsu, C-K; Yang, H-S; Chen, H-Y; Wong, T-W; Tsai, W-L; Chao, S-C; Lee, J Y-Y; Akiyama, M; Simpson, M A; McGrath, J A

    2015-04-01

    The physiology of human skin pigmentation is varied and complex, with an extensive melanogenic paracrine network involving mesenchymal and epithelial cells, contributing to the regulation of melanocyte survival and proliferation and melanogenesis. Mutations in several genes, involving predominantly the KIT ligand/c-Kit and Ras/mitogen-activated protein kinase signalling pathways, have been implicated in a spectrum of diseases in which there is hyperpigmentation, hypopigmentation or both. Here, we report on a 12-year-old girl from Taiwan with a 6-year history of diffuse progressive skin hyperpigmentation resulting from a different aetiology: an inborn metabolic disorder of vitamin B12 (cobalamin), designated cblJ. Using whole-exome sequencing we identified a homozygous mutation in ABCD4 (c.423C>G; p.Asn141Lys), which encodes an ATP-binding cassette transporter with a role in the intracellular processing of cobalamin. The patient had biochemical and haematological evidence of cobalamin deficiency but no other clinical abnormalities apart from a slight lightening of her previously black hair. Of note, she had no neurological symptoms or signs. Treatment with oral cobalamin (3 mg daily) led to metabolic correction and some reduction in the skin hyperpigmentation at the 3-month follow-up. This case demonstrates that defects or deficiencies of cobalamin should be remembered in the differential diagnosis of diffuse hyperpigmentary skin disorders. © 2014 British Association of Dermatologists.

  5. Molecular and metabolic pattern classification for detection of brain glioma progression

    Energy Technology Data Exchange (ETDEWEB)

    Imani, Farzin, E-mail: imanif@upmc.edu [Department of Radiology, University of Pittsburgh Medical Center, PA (United States); Boada, Fernando E. [Department of Radiology, University of Pittsburgh Medical Center, PA (United States); Lieberman, Frank S. [Department of Neurology, University of Pittsburgh Medical Center, PA (United States); Davis, Denise K.; Mountz, James M. [Department of Radiology, University of Pittsburgh Medical Center, PA (United States)

    2014-02-15

    Objectives: The ability to differentiate between brain tumor progression and radiation therapy induced necrosis is critical for appropriate patient management. In order to improve the differential diagnosis, we combined fluorine-18 2-fluoro-deoxyglucose positron emission tomography ({sup 18}F-FDG PET), proton magnetic resonance spectroscopy ({sup 1}H MRS) and histological data to develop a multi-parametric machine-learning model. Methods: We enrolled twelve post-therapy patients with grade 2 and 3 gliomas that were suspicious of tumor progression. All patients underwent {sup 18}F-FDG PET and {sup 1}H MRS. Maximal standardized uptake value (SUVmax) of the tumors and reference regions were obtained. Multiple 2D maps of choline (Cho), creatine (Cr), and N-acetylaspartate (NAA) of the tumors were generated. A support vector machine (SVM) learning model was established to take imaging biomarkers and histological data as input vectors. A combination of clinical follow-up and multiple sequential MRI studies served as the basis for assessing the clinical outcome. All vector combinations were evaluated for diagnostic accuracy and cross validation. The optimal cutoff value of individual parameters was calculated using Receiver operating characteristic (ROC) plots. Results: The SVM and ROC analyses both demonstrated that SUVmax of the lesion was the most significant single diagnostic parameter (75% accuracy) followed by Cho concentration (67% accuracy). SVM analysis of all paired parameters showed SUVmax and Cho concentration in combination could achieve 83% accuracy. SUVmax of the lesion paired with SUVmax of the white matter as well as the tumor Cho paired with the tumor Cr both showed 83% accuracy. These were the most significant paired diagnostic parameters of either modality. Combining all four parameters did not improve the results. However, addition of two more parameters, Cho and Cr of brain parenchyma contralateral to the tumor, increased the accuracy to 92

  6. Metabolism

    Science.gov (United States)

    ... functions: Anabolism (uh-NAB-uh-liz-um), or constructive metabolism, is all about building and storing. It ... in infants and young children. Hypothyroidism slows body processes and causes fatigue (tiredness), slow heart rate, excessive ...

  7. Metabolism

    Science.gov (United States)

    ... a particular food provides to the body. A chocolate bar has more calories than an apple, so ... acid phenylalanine, needed for normal growth and protein production). Inborn errors of metabolism can sometimes lead to ...

  8. Toxicology and metabolism of nickel compounds. Progress report, December 1, 1974--November 30, 1975. [97433ONE

    Energy Technology Data Exchange (ETDEWEB)

    Sunderman, F.W. Jr.

    1975-08-15

    The toxicology and metabolism of nickel compounds (NiCl/sub 2/, Ni/sub 3/S/sub 2/, NiS, and Ni powder) were investigated in rats and hamsters. The new knowledge has included: demonstration that hyperglucagonemia is primarily responsible for the acute hyperglycemic effect of parenteral Ni(II) in rats; demonstration that parenteral injection of Ni(II) in rats produces acute nephropathy with proteinuria and amino aciduria, and with ultrastructural lesions of renal glomeruli and tubules; confirmation of the inhibitory effect of manganese upon the carcinogenicity of Ni/sub 3/S/sub 2/ after intramuscular injection in rats, and elucidation of the effects of manganese upon the rates of excretion of nickel, and upon the acute histological reactions produced by Ni/sub 3/S/sub 2/; discovery that the antidotal efficacy of triethylenetetramine (TETA) in acute Ni(II) poisoning in rats is substantially greater than that of other chelating agents, including ..cap alpha..-lipoic acid, diethyldithiocarbamate, d-penicillamine, and glycylglycyl-L-histidine-N-methylamide; observation that the acute renal toxicity of Ni(II) is suppressed by administration of TETA, but that the hyperglycemic and hyperglucagonemic responses to Ni(II) are not prevented by TETA; confirmation that marked erythrocytosis is induced in rats by a single intrarenal injection of Ni/sub 3/S/sub 2/, and elucidation of the time-response and dose-response relationships for the Ni-induced erythrocytosis. (auth)

  9. Toxicology and metabolism of nickel compounds. Progress report, December 1, 1977--November 30, 1978

    Energy Technology Data Exchange (ETDEWEB)

    Sunderman, F.W. Jr.

    1978-08-15

    The toxicology and metabolism of nickel compounds (NiCl/sub 2/, ..cap alpha..Ni/sub 3/S/sub 2/, NiS, Ni powder, and Ni(CO)/sub 4/) were investigated in rats. The new knowledge includes: elucidation of dose-response and time-response relationships for teratogenicity of Ni(CO)/sub 4/ in rats. The specificity of Ni(CO)/sub 4/ for induction of ocular anomalies in rats appears to be unique among known teratogenic agents; demonstration that erythrocytosis induced in rats by intrarenal injection of ..cap alpha..Ni/sub 3/S/sub 2/ is (a) associated with increased serum erythropoietin activity and (b) suppressed by simultaneous injection of manganese; observation that manganese also suppresses industion of renal cancers in rats after intrarenal injection of aNi/sub 3/S/sub 2/; observation that in vitro exposure of Syrian hamster cells to ..cap alpha..Ni/sub 3/S/sub 2/ causes disorganization of cellular morphology, and that clones of such transformed cells cause tumors after sc injection in nude mice; acquisition of new information regarding pathophysiological mechanisms of nickel-induced hyperglycemia an nephrotoxicity; demonstration that D-penicillamine can serve as an alternative chelating agent for therapy of acute Ni(CO)/sub 4/ poisoning; and refinement of analytical methods for nickel in biological meterials, and application of urine nickel analyses for monitoring nickel-exposed workers.

  10. White sturgeon mitigation and restoration in the Columbia and Snake Rivers upstream from Bonneville Dam: annual progress report: April 1999 - March 2000; ANNUAL

    International Nuclear Information System (INIS)

    Ward, David L.

    2001-01-01

    We report on our progress from April 1999 through March 2000 on determining the effects of mitigative measures on productivity of white sturgeon populations in the Columbia River downstream from McNary Dam, and on determining the status and habitat requirements of white sturgeon populations in the Columbia and Snake rivers upstream from McNary Dam. The study is a cooperative effort by the Oregon Department of Fish and Wildlife (ODFW; Report A), Washington Department of Fish and Wildlife (WDFW; Report B), U.S. Geological Survey Biological Resources Division (USGS; Report C), Columbia River Inter-Tribal Fish Commission (CRITFC; Report D), and the U.S. Fish and Wildlife Service (USFWS; Report E). This is a multi-year study with many objectives requiring more than one year to complete. Therefore, findings from a given year may be part of more significant findings yet to be reported. Highlights of results of our work from April 1999 through March 2000 are given

  11. Electronics Research Laboratory, Plasma Theory and Simulation Group annual progress report, January 1, 1989--December 31, 1989

    International Nuclear Information System (INIS)

    Birdsall, C.K.

    1989-01-01

    This is a brief progress report, covering our research in general plasma theory and simulation, plasma-wall physics theory and simulation, and code development. Reports written in this period are included with this mailing. A publications list plus abstracts for two major meetings are included

  12. Shippingport Station Decommissioning Project: FYs 1984-1985 annual progress report, October 1, 1983 through September 30, 1985

    International Nuclear Information System (INIS)

    1987-01-01

    This report presents progress on the Shippingport Station Decommissioning Project for FYs 1984-85. There are three main topics: project management, decommissioning project activities, and issues of concern. The project purpose is demonstration of nuclear plant decommissioning and dismantlement operations in an environment of current industry practices. 8 refs., 8 figs., 2 tabs

  13. National flow cytometry and sorting research resource. Annual progress report, July, 1, 1994--June 30, 1995, Year 12

    Energy Technology Data Exchange (ETDEWEB)

    Jett, J.H.

    1995-04-27

    Research progress utilizing flow cytometry is described. Topics include: rapid kinetics flow cytometry; characterization of size determinations for small DNA fragments; statistical analysis; energy transfer measurements of molecular confirmation in micelles; and enrichment of Mus spretus chromosomes by dual parameter flow sorting and identification of sorted fractions by fluorescence in-situ hybridization onto G-banded mouse metaphase spreads.

  14. World bank and the environment: A progress report, fiscal year 1993. Annual report; Banque mondiale et l`environnement

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-03-01

    This fourth annual report examines how well the World Bank`s environmental policies have worked during fiscal year 1993. It presents an agenda of actions that will help countries manage their environment better and link environmental protection with sustainable development. It describes ways to improve environmental impact studies of Bank-financed projects. The report notes the World Bank`s improved public communications network and increased cofinancing for environmental projects. The Bank`s work in implementing Global Environment Facility (GEF) policies and the Montreal Protocol is also reviewed.

  15. Fiscal Year 1994 progress in implementing Section 120 of the Comprehensive Environmental Rresponse, Compensation, and Liability Act. Eighth annual report to Congress

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    Congress passed the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) (Public Law 96-510), commonly known as Superfund, in 1980. The Superfund Amendments and Reauthorization Act (SARA) (Public Law 99-499), which amended CERCLA in 1986, added Section 120 regarding the cleanup of contaminated sites at Federal facilities. Under Section 120(e)(5) of CERCLA, each department, agency, or instrumentality of the Federal government responsible for compliance with Section 120 must submit an annual report to Congress concerning its progress in implementing the requirements of Section 120. The report must include information on the progress in reaching Interagency Agreements (IAGs), conducting Remedial Investigation and Feasibility Studies (RI/FSs), and performing remedial actions. Federal agencies that own or operate facilities on the National Priorities List (NPL) are required to begin an RI/FS for these facilities within 6 months after being placed on the NPL. Remediation of these facilities is addressed in an IAG between the Federal agency, the U.S. Environmental Protection Agency (EPA), and in some instances the state within which the facility is located. This report, prepared by the U.S. Department of Energy`s (DOE`s) Office of Environmental Management, is being submitted to Congress in accordance with Section 120(e)(5) of CERCLA. It is DOE`s Eighth Annual Report to Congress and provides information on DOE`s progress in implementing CERCLA Section 120 in Fiscal Year 1994 (FY 94), i.e., from October 1, 1993, to September 30, 1994. In this report the words {open_quotes}site{close_quotes} and {open_quotes}facility{close_quotes} are used interchangeably.

  16. Fiscal Year 1994 progress in implementing Section 120 of the Comprehensive Environmental Rresponse, Compensation, and Liability Act. Eighth annual report to Congress

    International Nuclear Information System (INIS)

    1995-07-01

    Congress passed the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) (Public Law 96-510), commonly known as Superfund, in 1980. The Superfund Amendments and Reauthorization Act (SARA) (Public Law 99-499), which amended CERCLA in 1986, added Section 120 regarding the cleanup of contaminated sites at Federal facilities. Under Section 120(e)(5) of CERCLA, each department, agency, or instrumentality of the Federal government responsible for compliance with Section 120 must submit an annual report to Congress concerning its progress in implementing the requirements of Section 120. The report must include information on the progress in reaching Interagency Agreements (IAGs), conducting Remedial Investigation and Feasibility Studies (RI/FSs), and performing remedial actions. Federal agencies that own or operate facilities on the National Priorities List (NPL) are required to begin an RI/FS for these facilities within 6 months after being placed on the NPL. Remediation of these facilities is addressed in an IAG between the Federal agency, the U.S. Environmental Protection Agency (EPA), and in some instances the state within which the facility is located. This report, prepared by the U.S. Department of Energy's (DOE's) Office of Environmental Management, is being submitted to Congress in accordance with Section 120(e)(5) of CERCLA. It is DOE's Eighth Annual Report to Congress and provides information on DOE's progress in implementing CERCLA Section 120 in Fiscal Year 1994 (FY 94), i.e., from October 1, 1993, to September 30, 1994. In this report the words open-quotes siteclose quotes and open-quotes facilityclose quotes are used interchangeably

  17. Persons with secondary progressive and relapsing remitting multiple sclerosis reveal different responses of tryptophan metabolism to acute endurance exercise and training.

    Science.gov (United States)

    Bansi, Jens; Koliamitra, Christina; Bloch, Wilhelm; Joisten, Niklas; Schenk, Alexander; Watson, Matthew; Kool, Jan; Langdon, Dawn; Dalgas, Ulrik; Kesselring, Jürg; Zimmer, Philipp

    2018-01-15

    Disturbances in Tryptophan metabolism play a crucial role in multiple sclerosis (MS). Exercise is suspected to counteract the progress of MS and its side effects. Current research suggests alterations of Tryptophan metabolism in healthy individuals in response to exercise. We investigated the influence of acute aerobic exercise and training on Tryptophan metabolism in 57 inpatients with relapsing remitting ((RRMS) n=33) and secondary progressive ((SPMS) n=24) MS. Serotonin increased after training, whereas the kynurenine pathway was only activated in persons with RRMS. Further research is warranted to investigate whether these changes are associated with clinical measures (e.g. depressions and immune function). Copyright © 2017 Elsevier B.V. All rights reserved.

  18. The Community's research and development programme on decommissioning of nuclear power plants. Fourth annual progress report (year 1983)

    International Nuclear Information System (INIS)

    Anon.

    1985-01-01

    This is the fourth progress report of the European Community's program. (1979-83) of research on decommissioning of nuclear power plants. It covers the year 1983 and follows the 1980, 1981 and 1982 reports (EUR 7440, EUR 8343, EUR 8962). The present report describes the further progress of research and contains a large amount of results. For a majority of the 51 research contracts composing the 1979-83 programme, work was completed by the end of 1983; the conclusions drawn from this work are in this report. The European Community's program deals with the following fields: long-term integrity of buildings and systems; decontamination for decommissioning purposes; dismantling techniques; treatment of specific wastes materials (steel, concrete and graphite); large transport containers for radioactive waste produced in the dismantling of nuclear power plants; estimation of the quantities of radioactive waste arising from the decommissioning of nuclear power plants in the Community; influence of nuclear power plant design features on decommissioning

  19. The community's research and development programme on decommissioning of nuclear power plants. Third annual progress report (year 1982)

    International Nuclear Information System (INIS)

    1984-01-01

    This is the third progress report of the European Community's programme (1979-83) of research on the decommissioning of nuclear power plants. It covers the year 1982 and follows the 1980 and 1981 reports (EUR 7440, EUR 8343). Since 1982 was a very active year of research under the programme, this report contains a large amount of results. Besides, the work programmes of some additional research contracts, awarded through 1982, are described

  20. Dissecting the Variations of Ripening Progression and Flavonoid Metabolism in Grape Berries Grown under Double Cropping System

    Directory of Open Access Journals (Sweden)

    Wei-Kai Chen

    2017-11-01

    Full Text Available A double cropping system has been commercially adopted in southern China, where there is abundant sunshine and heat resources. In this viticulture system, the first growing season normally starts as a summer cropping cycle; then, the vine is pruned and forced, resulting in a second crop in winter. Due to climate differences between the summer and winter growing seasons, grape ripening progression and flavonoid metabolism vary greatly. Here, the metabolites and transcriptome of flavonoid pathways were analyzed in grapes grown under two growing seasons at different stages. Notably, the winter cropping cycle strongly increased flavonoid levels by several times in comparison to summer grapes, while the summer season took a major toll on anthocyanin and flavonol accumulation, since the winter cropping greatly triggered the expression of upstream genes in the flavonoid pathway in a coordinated expression pattern. Moreover, the ratio of VviF3′5′Hs (flavonoid 3′5′-hydroxylase to VviF3′Hs (flavonoid 3′-hydroxylase transcript levels correlated remarkably well with the ratio of 3′5′-substituted to 3′-substituted flavonoids, which was presumed to control the flux of intermediates into different flavonoid branches. On the other hand, the phenological phase also varied greatly in the two crops. Compared to summer cropping, winter growing season accelerated the duration from budburst to veraison, therefore advancing the onset of ripening, but also prolonging the duration of ripening progression due to the purposes to harvest high-quality grapes. The differential expression pattern of hormone-related genes between the two cropping cycles might explain this phenomenon.

  1. Ultrahigh sensitivity heavy noble gas detectors for long-term monitoring and monitoring air. 1998 annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Valentine, J.D. [Univ. of Cincinnati, OH (US); Gross, K. [Argonne National Lab., IL (US)

    1998-06-01

    'The primary objective of this research project is to develop heavy noble gas (krypton, xenon, and radon) detectors for: (1) long-term monitoring of transuranic waste, spent fuel, and other uranium and thorium bearing wastes, and (2) alpha particle air monitors that discriminate between radon emissions and other alpha emitters. A University of Cincinnati/Argonne National Laboratory (UC/ANL) Team has been assembled to complete this detector development project. DOE needs that are addressed by this project include improved long-term monitoring capability and improved air monitoring capability during remedial activities. Successful development and implementation of the proposed detection systems could significantly improve current capabilities with relatively simple and inexpensive equipment. As of June 1, 1998, the UC/ANL Team has: (1) made significant progress toward characterizing the fluid transfer process which is the basis for this detector development project and (2) evaluated several radiation detectors and several potential pulse processing schemes. The following discussion describes the progress made during the first year of this project and the implications of this progress.'

  2. Vegetation as an indicator of high wind velocity. Annual progress report, June 15, 1978--March 14, 1979

    Energy Technology Data Exchange (ETDEWEB)

    Hewson, E. W.; Wade, J. E.; Baker, R. W.

    1979-03-01

    The most important results are presented of work completed during the past year of the study Vegetation as an Indicator of High Wind Velocity. The most important achievement during the past year was the completion of a draft of a handbook on the use of trees as an indicator of wind power potential. This handbook describes relationships between mean annual wind speed and indices of wind deformation of two species of trees widely distributed in the western United States. Work during the past year on other species of trees indicates that the techniques calibrated initially for only Douglas-fir and Ponderosa Pine can also be calibrated on other trees including broadleaf trees such as oaks.

  3. Research in radiobiology. Annual report, Internal Irradiation Program

    International Nuclear Information System (INIS)

    Miller, S.C.; Buster, D.S.

    1985-01-01

    The annual progress report for the Radiobiology Division of the University of Utah College of Medicine is presented. Summaries of twenty-four projects concerning the metabolism, dosimetry and toxicity of a variety of actinide elements in beagles or rats are given. Individual papers within this report have been separately indexed and abstracted for the data base

  4. Annual report on major results and progress of Fusion Research and Development Directorate of JAEA from April 1, 2006 to March 31, 2007

    International Nuclear Information System (INIS)

    Suzuki, Satoshi; Ishii, Yasutomo; Sukegawa, Atsuhiko; Iwai, Yasunori; Nakamura, Hiroo; Sugie, Tatsuo

    2008-08-01

    This annual report provides an overview of major results and progress on research and development (R and D) activities at Fusion Research and Development Directorate of Japan Atomic Energy Agency (JAEA) from April 1, 2006 to March 31, 2007, including those performed in collaboration with other research establishments of JAEA, research institutes, and universities. In JT-60, as a result of ferritic steel tiles (FSTs) installation to reduce the toroidal field ripple and the application of the real time current profile control, high boot strap current fraction (∼0.7) has successfully been sustained about 8 s. In addition, the conceptual design of JT-60SA, which was placed as a combined project of JA-EU Satellite Tokamak Programme under the Broader Approach Programme and JAEA's programme for national use, was progressed. In theoretical and analytical researches, studies on ITB events and their triggers, plasma shape effect on edge stability and driven magnetic island evolution in rotating plasmas were progressed. In the NEXT project, computer simulations of the plasma turbulence were progressed. In fusion reactor technologies, R and Ds for ITER and fusion DEMO plants have been carried out. For ITER, a steady state operation of the 170GHz gyrotron up to 10min with 0.82MW was demonstrated. Also current density of the neutral beam injector has been extended to 146A/m 2 at 0.84MeV. In the ITER Test Blanket Module (TBM), designs and R and Ds of Water and Helium Cooled Solid Breeder TBMs including tritium breeder/multiplier materials were progressed. Tritium processing technology for breeding blankets and neutronics integral experiments with a blanket mockup were also progressed. For ITER and DEMO blankets, studies on neutron irradiation effects and ion irradiation effects on F82H steel characteristics were continued using HFIR, TIARA and so on. In the IFMIF program, transitional activities to EVEDA were continued. In the ITER Program, under the framework of the ITER

  5. Superconductivity program for electric systems, Superconductivity Technology Center, Los Alamos National Laboratory, annual progress report for fiscal year 1997

    Energy Technology Data Exchange (ETDEWEB)

    Willis, J.O.; Newnam, B.E. [eds.; Peterson, D.E.

    1999-03-01

    Development of high-temperature superconductors (HTS) has undergone tremendous progress during the past year. Kilometer tape lengths and associated magnets based on BSCCO materials are now commercially available from several industrial partners. Superconducting properties in the exciting YBCO coated conductors continue to be improved over longer lengths. The Superconducting Partnership Initiative (SPI) projects to develop HTS fault current limiters and transmission cables have demonstrated that HTS prototype applications can be produced successfully with properties appropriate for commercial applications. Research and development activities at LANL related to the HTS program for Fiscal Year 1997 are collected in this report. LANL continues to support further development of Bi2223 and Bi2212 tapes in collaboration with American Superconductor Corporation (ASC) and Oxford Superconductivity Technology, Inc. (OSTI), respectively. The tape processing studies involving novel thermal treatments and microstructural characterization have assisted these companies in commercializing these materials. The research on second-generation YBCO-coated conductors produced by pulsed-laser deposition (PLD) over buffer template layers produced by ion beam-assisted deposition (IBAD) continues to lead the world. The applied physics studies of magnetic flux pinning by proton and heavy ion bombardment of BSCCO and YBCO tapes have provided many insights into improving the behavior of these materials in magnetic fields. Sections 4 to 7 of this report contain a list of 29 referred publications and 15 conference abstracts, a list of patent and license activities, and a comprehensive list of collaborative agreements in progress and completed.

  6. Study of the radiation effects on nucleic acids and related compounds. Annual progress report, November 15, 1977--November 14, 1978

    International Nuclear Information System (INIS)

    Wang, S.Y.

    1978-07-01

    Acquisition of information on molecular biology involves four stages: establishment of procedures for the separation, isolation, and characterization of radiation products of nucleic acid bases, nucleosides, etc.; development of methods for the synthesis of these products once they are identified so that a constant supply in milligram to gram quantities is available for the studies in stages 3 and 4; examination of the apparent biological effects of each product in vitro and in vivo; and study of the molecular mechanism related to an observed biological phenomenon. In view of the difficulties experienced in this area of research and this deliberate and careful investigative approach, it was generally believed that progress toward our final goal would be rather prolonged. Yet the elucidation of a molecular mechanism by which ionizing radiation induces mutation in vivo is very near at hand. Further progress has been made in the separation and isolation of three hydroperoxy derivatives of thymidine. One communication has appeared and another has been submitted for publication. The former reports the efficient stereospecific synthesis of cis-pyrimidine glycols and the latter describes the study of mutagenicity and toxicity of seven radiation products of thymine and thymidine using Ames Salmonella test. Also, a quantitative study of the reversion of cytosine N(3)-oxide, a hydroperoxidation product induced by 6-TOOH, to cytosine has been carried out

  7. Climatic fluctuations, volcanic aerosol and carbon dioxide changes. Annual progress report, 1 October 1979-30 September 1980

    Energy Technology Data Exchange (ETDEWEB)

    Newell, R. E.

    1980-05-21

    Technical progress made for the contract period 1 October 1979-30 September 1980, and in fact since the last progress report was prepared on 18 June 1979, is summarized. The relationship between tropospheric air temperature, sea surface temperature patterns and volcanic aerosol has been derived by the application of generalized least squares analysis, which takes account of significant autocorrelation between the variables. Up to 50% of the variance of the tropical tropospheric air temperature can be explained in terms of preceding values of the variables. The technique is being applied to make a preliminary climatic forecast of the effect of the Mt. St. Helen's eruption of 18 May 1980 on zonal mean Northern Hemisphere temperature. A regression approach was used to forecast winter temperature over the continental US using parameters from out data base. Techniques for experimental climatic forecasting are being developed and studies of the background sea-air interaction processes are being made. We have shown that surface effects extend up to at least 500 mb in the atmosphere. Tropical rainfall has been found to vary with the Southern Oscillation Index; this rainfall provides the main energy supply to the atmosphere in the form of latent heat liberation.

  8. Community's research and development programme on radioactive waste management and storage shared-cost action (1990-94). Annual progress report 1991

    International Nuclear Information System (INIS)

    1992-01-01

    In december 1989 the Council of Ministers of the European Communities adopted the fourth R and D programme on 'Management and Storage of radioactive waste' for the period 1990-1994. Contract negotiations for selected research proposals lead to the signature of contracts with some 93 bodies in charge of carrying out the working programme. This annual report, covering the year 1991 presents for each contract the objectives, the whole research programme and a synopsis of progress and results achieved as prepared by the contractor under the responsibility of the project leader. Part A deals with the study of management systems, treatment and characterization of waste, general aspects of the waste disposal and the safety of geological disposal systems. The running activities on construction and operation of underground facilities in candidated geological media for disposal is presented in part B

  9. The Community's research and development programme on radioactive waste management and storage shared cost action annual progress report 1989 volume 1

    International Nuclear Information System (INIS)

    1990-01-01

    In 1985 the Council of Ministers of the European Communities adopted a five-year R and D programme on 'Management and storage of radioactive waste' for the period 1985-89. The R and D programme was carried out by public organizations and private firms in the Member States. By the end of 1989 over 256 contracts had been concluded with some 70 bodies. This annual report, covering the year 1989, is the fourth of its type. For each contract it gives the objectives, working programme and a summary of progress and results obtained as prepared by the contractor under the responsibility of the project leader. The report contains sections on treatment and conditioning of radioactive waste, characterization of conditioned radioactive waste, general aspects of radioactive waste disposal, and the performance of isolation systems

  10. The Community's research and development programme on radioactive waste management and storage shared cost action annual progress report 1989 volume 2

    International Nuclear Information System (INIS)

    1990-01-01

    In 1985 the Council of Ministers of the European Communities adopted a five-year R and D programme on 'Management and storage of radioactive waste' for the period 1985-89. The R and D programme was carried out by public organizations and private firms in the Member States. By the end of 1989 over 256 contracts had been concluded with some 70 bodies. This annual report, covering the year 1989, is the fourth of its type. For each contract it gives the objectives, working programme and a summary of progress and results obtained as prepared by the contractor under the responsibility of the project leader. The report contains sections on treatment and conditioning of radioactive waste, characterization of conditioned radioactive waste, general aspects of radioactive waste disposal, and the performance of isolation systems

  11. Identification of the Spawning, Rearing, and Migratory Requirements of Fall Chinook Salmon in the Columbia River Basin, 1991 Annual Progress Report.

    Energy Technology Data Exchange (ETDEWEB)

    Rondorf, Dennis W.; Miller, William H.

    1993-07-01

    This document is the 1991 annual progress report for selected studies of fall chinook salmon Oncorhynchus tshawytscha conducted by the US Fish and Wildlife Service. The decline in abundance of fall chinook salmon in the Snake River basin has become a growing concern. In April 1992, Snake River fall chinook salmon were listed as ``threatened`` under the Endangered Species Act. Effective recovery efforts for fall chinook salmon can not be developed until we increase our knowledge of the factors that are limiting the various life history stages. This study attempts to identify those physical and biological factors which influence spawning of fall chinook salmon in the free-flowing Snake River and their rearing and seaward migration through Columbia River basin reservoirs.

  12. Kokanee Stock Status and Contribution of Cabinet Gorge Hatchery, Lake Pend Oreille, Idaho, 1985 Annual Progress Report.

    Energy Technology Data Exchange (ETDEWEB)

    Bowles, Edward C.

    1986-07-01

    Mid-water trawling techniques were used during September to estimate kokanee population abundance, structure and survival. Abundance in 1985 was estimated at 4.5 million fish (198 per hectare), down from over 12 million kokanee in 1974 when the population was first monitored. Hatchery fry production (<6 million annually) has stabilized kokanee abundance since its initial decline in the late 1960s. Wild fry recruitment has remained relatively stable at 1.8 million since 1978; whereas recruitment of hatchery-reared fry has ranged from 0.09 to 1.98 million. The 1985 creel survey indicated that kokanee harvest rates remain low, with approximately one kokanee harvested per hour of effort from April to August. Catch rates were as high as 3.5 fish per hour during the mid-1960s. The zooplankton community was monitored with periodic plankton tows. Zooplankton composition in 1985 was similar to previous years and appears to have stabilized following the introduction of mysids, with peak cladoceran production occurring several weeks after peak kokanee emergence. Delayed release of hatchery fry resulted in higher survival of hatchery (7.3%) than wild (0.43%) kokanee fry. Other release strategies will be tested as more fry become available.

  13. Annual technology assessment and progress report for the buried transuranic waste program at the Idaho National Engineering Laboratory

    International Nuclear Information System (INIS)

    Berreth, P.D.

    1984-11-01

    The US Department of Energy (DOE) is responsible for developing and implementing methods for the safe and environmentally acceptable disposal of radioactive waste. In 1983, DOE formulated a comprehensive plan to manage transuranic (TRU) defense waste. The DOE plan for buried TRU waste is to monitor it, take remedial actions as necessary, and reevaluate its safety periodically. The DOE strategy reflects concern that, based on present technology, retrieval and processing of buried waste may be risky and costly. To implement the DOE plan, EG and G Idaho, Inc., prime contractor at the Idaho National Engineering Laboratory (INEL), has developed a strategy for long-term management of the 2 million cubic feet of INEL buried TRU waste. That strategy involves four main activities: (a) environmental monitoring, (b) remedial action if necessary, (c) assimilation of data from both special studies and ongoing waste management activities, and (d) selection of a long-term management alternative in 1995. This report, submitted as the first in a series of annual reports, summarizes the buried TRU waste activities performed in fiscal year (FY) 1984 at the INEL in response to the DOE plan. Specifically, technologies applicable to buried waste confinement, retrieval, certification, and processing have been assessed, a long-range plan to conduct buried wasted studies over the next ten years has been prepared, and retrieval and soil management alternatives have been evaluated. 17 references, 7 figures, 1 table

  14. Transuranium element transport in agricultural systems (soil to food chain transfer of nuclear fuel cycle radionuclides). Annual progress report

    International Nuclear Information System (INIS)

    Wallace, A.

    1977-10-01

    Progress is reported on the following research projects: preparation of bibliography covering literature on plant uptake of transuranium elements; development of techniques for growth of agricultural crops in large containers that simulate field conditions; equipment for counting of alpha-emitting transuranium elements; studies on variability in concentration ratio of 241 Am under different environmental conditions; alpha radiation burn in bush beans exposed to 241 Am in solution; constancy of concentration ratio as a measure of plant uptake of 241 Am; growth of radishes in soil with and without DTPA, and radish peel as source of radionuclides; effects of varying levels of DTPA in loam soil on concentration ratio values; and a plant species (Atriplex hymenelytra--desert holly) with high C.R. values and search for other plants with high C.R. values

  15. Managing tight-binding receptors for new separations technologies. Annual progress report, September 15, 1996 - June 10, 1997

    International Nuclear Information System (INIS)

    Busch, D.H.; Givens, R.S.

    1997-01-01

    'This program is fully staffed and all proposed investigations are proceeding as outlined in the Task Schedule of the original proposal. The program aims remain unchanged and excellent progress is reported below. The authors anticipate no substantial unexpended funds from the first year''s budget at the end of the first year of support. Any such remaining funds will certainly be less than 10% of the budget; less than 5% is expected. Three projects make up this program and each focuses on a single aspect of the major problem of overcoming the inherent slow reaction rates of tight-binding ligands. In a logical order, Project 1 addresses the rates of formation of metal complexes using tight-binding ligands; Project 2 addresses the rate of release of metal ions from complexes with tight-binding ligands; and Project 3 provides the possibility of a new technology that should be unimpeded by the inherent dilatory rates.'

  16. Managing tight-binding receptors for new separations technologies. Annual progress report, September 15, 1996--June 10, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Busch, D.H.; Givens, R.S.

    1997-01-01

    'This program is fully staffed and all proposed investigations are proceeding as outlined in the Task Schedule of the original proposal. The program aims remain unchanged and excellent progress is reported below. The authors anticipate no substantial unexpended funds from the first year''s budget at the end of the first year of support. Any such remaining funds will certainly be less than 10% of the budget; less than 5% is expected. Three projects make up this program and each focuses on a single aspect of the major problem of overcoming the inherent slow reaction rates of tight-binding ligands. In a logical order, Project 1 addresses the rates of formation of metal complexes using tight-binding ligands; Project 2 addresses the rate of release of metal ions from complexes with tight-binding ligands; and Project 3 provides the possibility of a new technology that should be unimpeded by the inherent dilatory rates.'

  17. Experimental studies of nucleon-nucleon and pion-nucleus interactions at intermediate energies: Annual progress report, 1988--1989

    International Nuclear Information System (INIS)

    1988-01-01

    This report summarizes the work on experimental research in intermediate energy nuclear and particle physics carried out by New Mexico State University in 1988 under a grant from the US Department of Energy. The nucleon-nucleon research has involved studies of interactions between polarized neutrons and polarized protons. Its purpose is to help complete the determination of the nucleon-nucleon amplitudes at energies up to 800 MeV, as part of a program currently in progress at LAMPF, as well as to investigate the possibility of the existence of dibaryon resonances. The pion-nucleus research involves studies of this interaction in regions where it has not been adequately explored. These include experiments on elastic and double charge exchange scattering at energies above the /Delta/(1232) resonance, interactions with polarized nuclear targets, and investigations of pion absorption using a detector covering nearly the full solid angle region. 21 refs., 4 figs

  18. Innovative techniques for the description of reservoir heterogeneity using tracers. Second technical annual progress report, October 1991--September 1992

    Energy Technology Data Exchange (ETDEWEB)

    Pope, G.A.; Sepehrnoori, K.

    1992-12-31

    This second annual report on innovative uses of tracers for reservoir characterization contains four sections each describing a novel use of oilfield tracers. The first section describes and illustrates the use of a new single-well tracer test to estimate wettability. This test consists of the injection of brine containing tracers followed by oil containing tracers, a shut-in period to allow some of the tracers to react, and then production of the tracers. The inclusion of the oil injection slug with tracers is unique to this test, and this is what makes the test work. We adapted our chemical simulator, UTCHEM, to enable us to study this tracer method and made an extensive simulation study to evaluate the effects of wettability based upon characteristic curves for relative permeability and capillary pressure for differing wetting states typical of oil reservoirs. The second section of this report describes a new method for analyzing interwell tracer data based upon a type-curve approach. Theoretical frequency response functions were used to build type curves of ``transfer function`` and ``phase spectrum`` that have dimensionless heterogeneity index as a parameter to characterize a stochastic permeability field. We illustrate this method by analyzing field tracer data. The third section of this report describes a new theory for interpreting interwell tracer data in terms of channeling and dispersive behavior for reservoirs. Once again, a stochastic approach to reservoir description is taken. The fourth section of this report describes our simulation of perfluorocarbon gas tracers. This new tracer technology developed at Brookhaven National Laboratory is being tested at the Elk Hills Naval Petroleum Reserve No. 1 in California. We report preliminary simulations made of these tracers in one of the oil reservoirs under evaluation with these tracers in this field. Our compostional simulator (UTCOMP) was used for this simulation study.

  19. Annual Progress Report on the Development of Waste Tank Leak Monitoring and Detection and Mitigation Activities in Support of M-45-08

    International Nuclear Information System (INIS)

    DEFIGH PRICE, C.

    2000-01-01

    Milestone M-45-09E of the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement or TPA) [TPA 1996] requires submittal of an annual progress report on the development of waste tank leak detection, monitoring, and mitigation (LDMM) activities associated with the retrieval of waste from single-shell tanks (SSTs). This report details progress for fiscal year 2000, building on the current LDMM strategy and including discussion of technologies, applications, cost, schedule, and technical data. The report also includes discussion of demonstrations conducted and recommendations for additional testing. Tri-Party Agreement Milestones M-45-08A and M-45-08B required design and demonstration of LDMM systems for initial retrieval of SST waste. These specific milestones have recently been deleted as part of the M-45-00A change package. Future LDMM development work has been incorporated into specific technology demonstration milestones and SST waste retrieval milestones in the M-45-03 and M-45-05 milestone series

  20. Fiscal year 1996 progress in implementing Section 120 of the Comprehensive Environmental Response, Compensation, and Liability Act. Tenth annual report to Congress

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-01

    Congress passed the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) (Public Law 96-510), commonly known as Superfund, in 1980. The Superfund Amendments and Reauthorization Act (SARA) (Public Law 99-499), which amended CERCLA in 1986, added Section 120 regarding the cleanup of contaminated sites at Federal facilities. Under Section 120(e)(5) of CERCLA, each department, agency, or instrumentality of the Federal government responsible for compliance with Section 120 must submit an annual report to Congress concerning its progress in implementing the requirements of Section 120. The report must include information on the progress in reaching Interagency Agreements (IAGs), conducting remedial investigation and feasibility studies (RI/FSs), and performing remedial actions. Federal agencies that own or operate facilities on the National Priorities List (NPL) are required to begin an RI/FS for these facilities within 6 months after being placed on the NPL. Remediation of these facilities is addressed in an IAG between the Federal agency, the US Environmental Protection Agency (EPA), and in some instances the state within which the facility is located.

  1. Joint inversion of geophysical data for site characterization and restoration monitoring. FY97 annual progress report for EMSP

    International Nuclear Information System (INIS)

    Berge, P.A.; Berryman, J.G.; Bonner, B.P.; Roberts, J.J.; Wildenschild

    1997-01-01

    'The purpose of this project is to develop a computer code for joint in-version of seismic and electrical data, to improve underground imaging for site characterization and remediation monitoring. The computer code developed in this project will invert geophysical data to obtain direct estimates of porosity and saturation underground, rather than inverting for seismic velocity and electrical resistivity or other geophysical properties. This is intended to be a significant improvement in the state-of-the-art of under-ground imaging, since interpretation of data collected at a contaminated site would become much less subjective. The schedule of this project is as follows: In the first year, investigators perform laboratory measurements of elastic and electrical properties of sand-clay mixtures containing various fluids. Investigators also develop methods of relating measurable geophysical properties to porosity and saturation by using rock physics theories, geostatistical, and empirical techniques together with available laboratory measurements. In the second year, investigators finish any necessary laboratory measurements and apply the methods developed in the first year to invert available borehole log data to predict measured properties of cores and sediments from a borehole. Investigators refine the inversion code in the third year and carry out a field experiment to collect seismic and electrical data. Investigators then use the inversion code to invert the field data to produce estimates of porosity and saturation in the field area where the data were collected. This report describes progress made in the first year of this three-year project.'

  2. Experimental and theoretical high energy physics research. Annual grant progress report (FDP), January 15, 1993--January 14, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Cline, D.B.

    1993-10-01

    Progress on seven tasks is reported. (I)UCLA hadronization model, antiproton decay, PEP4/9 e{sup +}e{sup {minus}} analysis: In addition to these topics, work on CP and CPT phenomenology at a {phi} factory and letters of support on the hadronization project are included. (II)ICARUS detector and rare B decays with hadron beams and colliders: Developments are summarized and some typcial events as shown; in addition, the RD5 collaboration at CERN and the asymmetric {phi} factory project are sketched. (III)Theoretical physics: Feynman diagram calculations in gauge theory; supersymmetric standard model; effects of quantum gravity in breaking of global symmetries; models of quark and lepton substructure; renormalized field theory; large-scale structure in the universe and particle-astrophysics/early universe cosmology. (IV)H dibaryon search at BNL, kaon experiments (E799/KTeV) at Fermilab: Project design and some scatterplots are given. (V)UCLA participation in the experiment CDF at Fermilab. (VI)Detectors for hadron physics at ultrahigh energy colliders: Scintillating fiber and visible light photon counter research. (VII)Administrative support and conference organization.

  3. Advanced light water reactor plants System 80+{trademark} design certification program. Annual progress report, October 1, 1995--September 30, 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    The purpose of this report is to provide a status of the progress that was made towards Design Certification of System 80+{trademark} during the US government`s 1996 fiscal year. The System 80+ Advanced Light Water Reactor (ALWR) is a 3931 MW (1350 MWe) Pressurized Water Reactor (PWR). The design covers an essentially complete plant. It is based on EPRI ALWR Utility Requirements Document (URD) improvements to the Standardized System 80 Nuclear Steam Supply System (NSSS) in operation at Palo Verde Units 1, 2 and 3. The NSSS is a traditional two-loop arrangement with two steam generators, two hot legs and four cold legs, each with a reactor coolant pump. The System 80+ standard design houses the NSSS in a spherical steel containment vessel which is enclosed in a concrete shield building, thus providing the safety advantages of a dual barrier to radioactivity release. Other major features include an all-digital, human-factors-engineered control room, an alternate electrical AC power source, an In-Containment Refueling Water Storage Tank (IRWST), and plant arrangements providing complete separation of redundant trains in safety systems.

  4. Twin boundaries, interfaces and modulated structures in martensites: Annual progress report No. 4, July 1, 1988--June 30, 1989

    Energy Technology Data Exchange (ETDEWEB)

    Barsch, G.R.

    1989-03-15

    A comprehensive theoretical study with concurrent supporting experimental investigations is being carried out on coherent and semicoherent interfaces in ferroelastic martensites, including twin boundaries and twin bands, heterophase parent/product interfaces and inclusions, and transformation precursors. This work is motivated by the need for a new theoretical basis for investigating the martensite nucleation mechanism and for establishing the conditions for nonclassical nucleation. Soliton-like solutions of a dynamic Ginzburg-Landau continuum theory for ferroelastic martensites are being studied in order to determine the strain distribution, strain energy and dynamical behavior for various geometric configurations as a function of the material parameters, temperature and boundary conditions. Model parameters of the theory consist of the second and higher order elastic constants and the harmonic strain gradient coefficients in the parent phase. X-ray measurements of the transformation strain versus temperature, and ultrasonic velocity and attenuation measurements on biaxially stressed crystals in In/sub 1-x/Tl/sub x/ alloys for determining the second and higher order elastic constants in the single domain tetragonal state and for studying the morphology and the dynamic behavior of the martensite interfaces and transformation precursors are in progress. 6 refs.

  5. Advanced light water reactor plants System 80+{trademark} design certification program. Annual progress report, October 1, 1994--September 30, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    The purpose of this report is to provide the status of the progress that was made towards Design Certification of System 80+{trademark} during the US government`s 1995 fiscal year. The System 80+ Advanced Light Water Reactor (ALWR) is a 3931 MW (1350 MWe) Pressurized Water Reactor (PWR). The design covers an essentially complete plant. It is based on EPRI ALWR Utility Requirements Document (URD) improvements to the Standardized System 80 Nuclear Steam Supply System (NSSS) in operation at Palo Verde Units 1, 2, and 3. The NSSS is a traditional two-loop arrangement with two steam generators, two hot legs and four cold legs, each with a reactor coolant pump. The System 80+ standard design houses the NSSS in a spherical steel containment vessel which is enclosed in a concrete shield building, thus providing the safety advantages of a dual barrier to radioactivity release. Other major features include an all-digital, human-factors-engineered control room, an alternate electrical AC power source, an In-Containment Refueling Water Storage Tank (IRWST), and plant arrangements providing complete separation of redundant trains in safety systems.

  6. Advanced light water reactor plants System 80+trademark design certification program. Annual progress report, October 1, 1994 - September 30, 1995

    International Nuclear Information System (INIS)

    1998-01-01

    The purpose of this report is to provide the status of the progress that was made towards Design Certification of System 80+trademark during the US government's 1995 fiscal year. The System 80+ Advanced Light Water Reactor (ALWR) is a 3931 MW (1350 MWe) Pressurized Water Reactor (PWR). The design covers an essentially complete plant. It is based on EPRI ALWR Utility Requirements Document (URD) improvements to the Standardized System 80 Nuclear Steam Supply System (NSSS) in operation at Palo Verde Units 1, 2, and 3. The NSSS is a traditional two-loop arrangement with two steam generators, two hot legs and four cold legs, each with a reactor coolant pump. The System 80+ standard design houses the NSSS in a spherical steel containment vessel which is enclosed in a concrete shield building, thus providing the safety advantages of a dual barrier to radioactivity release. Other major features include an all-digital, human-factors-engineered control room, an alternate electrical AC power source, an In-Containment Refueling Water Storage Tank (IRWST), and plant arrangements providing complete separation of redundant trains in safety systems

  7. Advanced light water reactor plants System 80+trademark design certification program. Annual progress report, October 1, 1995 - September 30, 1996

    International Nuclear Information System (INIS)

    1996-01-01

    The purpose of this report is to provide a status of the progress that was made towards Design Certification of System 80+trademark during the US government's 1996 fiscal year. The System 80+ Advanced Light Water Reactor (ALWR) is a 3931 MW (1350 MWe) Pressurized Water Reactor (PWR). The design covers an essentially complete plant. It is based on EPRI ALWR Utility Requirements Document (URD) improvements to the Standardized System 80 Nuclear Steam Supply System (NSSS) in operation at Palo Verde Units 1, 2 and 3. The NSSS is a traditional two-loop arrangement with two steam generators, two hot legs and four cold legs, each with a reactor coolant pump. The System 80+ standard design houses the NSSS in a spherical steel containment vessel which is enclosed in a concrete shield building, thus providing the safety advantages of a dual barrier to radioactivity release. Other major features include an all-digital, human-factors-engineered control room, an alternate electrical AC power source, an In-Containment Refueling Water Storage Tank (IRWST), and plant arrangements providing complete separation of redundant trains in safety systems

  8. Radiation and chemical effects on viral transformation and tumor antigen expression. Annual progress report, August 1, 1978--May 1, 1979

    International Nuclear Information System (INIS)

    Coggin, J.H. Jr.

    1979-01-01

    Studies aimed at the biological, biochemical, and immunologic characterization of fetal antigens (EA) in hamsters and mice and locating and determining the distribution of fetal antigens in tumor tissues and in developing fetuses have been underway for several months. Progress has been made in isolating embryonic or fetal antigens from fetuses and from tumor cells. We have developed and reported a reliable lymphocyte transformation assay (LTA) which meets our needs in routinely assaying cell free tumor associated antigen (TAA) preparations from fetal and tumor cells. The assay correlated with transplantation resistance assays and has appropriate specificity. We have also developed the staph-A protein binding assay utilizing anti-serum derived against embryonic antigens present on SV40 tumor cells. In other studies, we have reported increases and perturbations in thymocytes during viral and chemical oncogenesis in hamsters, have developed a simple technique for preserving functional lymphocytes sensitized against TAA by freezing for use in our model system work, have reported the cross-reactivity of tranplantation resistance antigen on a spectrum of chemically induced tumors previously believed to only contain individually specific TSTAs and have recently reported the cross-reactivity of papovavirus induced transplantation resistance antigen in sarcoma cells induced by different viruses. We have concluded our studies of glycosyltransferases in the membranes of developing fetuses and noted no differences in their levels with advancing days of gestation using whold embryo cell populations

  9. The delineation and interpretation of the earth's gravity field. Annual progress report, 1 June 1988-31 May 1989

    International Nuclear Information System (INIS)

    Marsh, B.D.

    1989-05-01

    In an attempt to understand the mechanical interaction of a growing lithosphere containing fracture zones with small and large scale mantle convection, which gives rise to geoid anomalies in oceanic regions, a series of fluid dynamical experiments is in progress to investigate: (1) the influence of lithosphere structure, fluid depth and viscosity field on the onset, scale, and evolution of sublithospheric convection; (2) the role of this convection in determining the rate of growth of lithosphere, especially in light of the flattening of the lithosphere bathymetry and heat flow at late times; and (3) combining the results of both numerical and laboratory experiments to decide the dominate factors in producing geoid anomalies in oceanic regions through the thermo-mechanical interaction of the lithosphere and subjacent mantle. The clear existence of small scale convection associated with a downward propagating solidification front (i.e., the lithosphere) and a larger scale flow associated with a discontinuous upward heat flux (i.e., a fracture zone) has been shown. The flows exist simultaneously and each may have a significant role in deciding the thermal evolution of the lithosphere and in understanding the relation of shallow mantle convection to deep mantle convection. This overall process is reflected in the geoid, gravity, and topographic anomalies in the north-central Pacific. These highly correlated fields of intermediate wavelength (approx. 200 to 2000 km) show isostatic compensation by a thin lithosphere for shorter (less than or equal to approx. 500 km), but not the longer, wavelengths. The ultimate, dynamic origin of this class of anomalies is being investigated

  10. Annual progress report of the Fontenay-aux-Roses Research Group. January 1 to December 31 1978

    International Nuclear Information System (INIS)

    Within the context of the TFR programme, the problem of balance again filled a significant place in 1978. The 1978 work resulted in partial successes only from the practical angle by ensuring long discharges of 150 to 200 KA, but they made it possible to reach a comprehensive understanding of the problem by using a sophisticated digital model that is a very good representation of the change in the plasma connected to outside circuits. Despite some technical difficulties, it was fortunately possible to obtain fine results on the ionic cyclotron heating. Significant progress was made in the field of diagnoses, particularly local temperature measurements and resolved with time which are so important for the development of heating methods and for the studies of pure physics. With the improvements also made in the other domains, TFR once more possesses a panoply of diagnoses that has not many equals. Another important event was the order for nine sources of the circular periplasmatron type by the I.P.P. of Garching to fit out the neutral injection lines of ASDEX. In the area of neutrals, the development work on JET, being pursued vigorously, should also be noted. Then there is also the franco-sovietic cooperation work with Tl0, particularly for the measurement of the electronic temperature by cyclotronic emission. Last, the TFR 604 and TORE II projects have undergone some change, the first with respect to the injection of 4MW tangential neutrals into the plasma and the second concerning the use of superconducting coils (TORE II SUPRA version) to create the toroidal field [fr

  11. Novel ceramic-polymer composite membranes for the separation of hazardous liquid waste. 1998 annual progress report

    International Nuclear Information System (INIS)

    Cohen, Y.

    1998-01-01

    'This report summarizes the work progress over the last 1.75 years of a 3 year project. The objectives of the project have been to develop a new class of ceramic-supported polymeric membranes that could be tailored-designed for a wide-range of applications in remediation and pollution prevention. To date, a new class of chemically-modified ceramic membranes was developed for the treatment of oil-in-water emulsions and for the pervaporation removal of volatile organics from aqueous systems. These new ceramic-supported polymer (CSP) membranes are fabricated by modifying the pore surface of a ceramic membrane support by a graft polymerization process (Chaimberg and Cohen, 1994). The graft polymerization process consists of activating the membrane surface with alkoxy vinyl silanes onto which vinyl monomers are added via free-radical graft polymerization resulting in a thin surface layer of terminally anchored polymer chains. Reaction conditions are selected based on knowledge of the graft polymerization kinetics for the specific polymer/substrate system. The resultant ceramic-supported polymer (CSP) membrane is a composite structure in which mechanical strength is provided by the ceramic support and the selectivity is determined by the covalently bonded polymer brush layer. Thus, one of the unique attributes of the CSP membrane is that it can be used in environments where the polymer layer is swollen (or even completely miscible) in the mixture to be separated (Castro et al., 1993). It is important to note that the above modification process is carried out under mild conditions (e.g., temperature of about 70 C) and is well suited for large scale commercial application. In a series of studies, the applicability of a polyvinylpyrrolidone CSP membrane was demonstrated for the treatment of oil-in-water emulsion under a variety of flow conditions (Castro et al.,1996). Improved membrane performance was achieved due to minimization of surface adsorption of the oil components

  12. Progress report on nuclear science and technology in China (Vol.2). Proceedings of academic annual meeting of China Nuclear Society in 2011, No.10--nuclear Information sub-volume

    International Nuclear Information System (INIS)

    2012-10-01

    Progress report on nuclear science and technology in China (Vol. 2) includes 698 articles which are communicated on the second national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the tenth one, the content is about nuclear Information and computer applications

  13. Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.6--computational physics sub-volume

    International Nuclear Information System (INIS)

    2014-05-01

    Progress report on nuclear science and technology in China (Vol. 3) includes 13 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the sixth one, the content is about computational physics sub-volume

  14. Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.8--nuclear agriculture sub-volume

    International Nuclear Information System (INIS)

    2014-05-01

    Progress report on nuclear science and technology in China (Vol. 3) includes 10 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the eighth one, the content is about nuclear agriculture sub-volume

  15. Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.2--uranium mining and metallurgy sub-volume

    International Nuclear Information System (INIS)

    2014-05-01

    Progress report on nuclear science and technology in China (Vol. 3) includes 48 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the second one, the content is about uranium mining and metallurgy sub-volume

  16. Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.3--nuclear power sub-volume (Pt.2)

    International Nuclear Information System (INIS)

    2014-05-01

    Progress report on nuclear science and technology in China (Vol. 3) includes 86 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the third one, the content is about nuclear power sub-volume (Pt.2)

  17. Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.4--isotope separation sub-volume

    International Nuclear Information System (INIS)

    2014-05-01

    Progress report on nuclear science and technology in China (Vol. 3) includes 37 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the fourth one, the content is about isotope separation sub-volume

  18. Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.8--radiation research and its application sub-volume

    International Nuclear Information System (INIS)

    2014-05-01

    Progress report on nuclear science and technology in China (Vol. 3) includes 12 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the eighth one, the content is about radiation research and its application sub-volume

  19. Progress report on nuclear science and technology in China (Vol.1). Proceedings of academic annual meeting of China Nuclear Society in 2009, No.2--nuclear power sub-volume (Pt.1)

    International Nuclear Information System (INIS)

    2010-11-01

    Progress report on nuclear science and technology in China (Vol. 1) includes 889 articles which are communicated on the first national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the second one, the content is about uranium mining, uranium metallurgy and nuclear power.

  20. Progress report on nuclear science and technology in China (Vol.1). Proceedings of academic annual meeting of China Nuclear Society in 2009, No.2--uranium mining and metallurgy sub-volume

    International Nuclear Information System (INIS)

    2010-11-01

    Progress report on nuclear science and technology in China (Vol. 1) includes 889 articles which are communicated on the first national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the second one, the content is about uranium mining, uranium metallurgy and nuclear power.

  1. Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.7--pulse power technology and its application sub-volume

    International Nuclear Information System (INIS)

    2014-05-01

    Progress report on nuclear science and technology in China (Vol. 3) includes 18 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the seventh one, the content is about pulse power technology and its application sub-volume

  2. Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.6--particle accelerator sub-volume

    International Nuclear Information System (INIS)

    2014-05-01

    Progress report on nuclear science and technology in China (Vol. 3) includes 10 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the sixth one, the content is about particle accelerator sub-volume

  3. Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.7--nuclear fusion and plasma physics sub-volume

    International Nuclear Information System (INIS)

    2014-05-01

    Progress report on nuclear science and technology in China (Vol. 3) includes 22 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the seventh one, the content is about nuclear fusion and plasma physics sub-volume

  4. Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.10--nuclear technology economy and management modernization sub-volume

    International Nuclear Information System (INIS)

    2014-05-01

    Progress report on nuclear science and technology in China (Vol. 3) includes 18 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the tenth one, the content is about nuclear technology economy and management modernization sub-volume

  5. Progress report on nuclear science and technology in China (Vol.2). Proceedings of academic annual meeting of China Nuclear Society in 2011, No.7--Nuclear electronics and nuclear detection technology sub-volume

    International Nuclear Information System (INIS)

    2012-10-01

    Progress report on nuclear science and technology in China (Vol. 2) includes 698 articles which are communicated on the second national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the seventh one, the content is about Nuclear electronics and nuclear detection technology

  6. Progress report on nuclear science and technology in China (Vol.2). Proceedings of academic annual meeting of China Nuclear Society in 2011, No.8--radiation research and its application sub-volume

    International Nuclear Information System (INIS)

    2012-10-01

    Progress report on nuclear science and technology in China (Vol. 2) includes 698 articles which are communicated on the second national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the eighth one, the content is about radiation research and its application

  7. Progress report on nuclear science and technology in China (Vol.1). Proceedings of academic annual meeting of China Nuclear Society in 2009, No.8--radiation research and radiation technology

    International Nuclear Information System (INIS)

    2010-11-01

    Progress report on nuclear science and technology in China (Vol. 1) includes 889 articles which are communicated on the first national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the eighth one, the content is about radiation study, radiation technology, isotope and nuclear agriculture

  8. Annual benthic metabolism and organic carbon fluxes in a semi-enclosed Mediterranean bay dominated by the macroalgae Caulerpa prolifera.

    Directory of Open Access Journals (Sweden)

    Sergio eRuiz-Halpern

    2014-12-01

    Full Text Available Coastal areas play an important role on carbon cycling. Elucidating the dynamics on the production, transport and fate of organic carbon is relevant to gain a better understanding of the role coastal areas play in the global carbon budget. Here, we assess the metabolic status and associated organic carbon fluxes of a semi-enclosed Mediterranean bay supporting a meadow of Caulerpa prolifera. We test whether the EDOC pool is a significant component of the organic carbon pool and associated fluxes in this ecosystem. The Bay of Portocolom was in net metabolic balance on a yearly basis, but heterotrophic during the summer months. Community respiration (CR was positively correlated to C. prolifera biomass, while net community production (NCP had a negative correlation. The benthic compartment represented, on average, 72.6 ± 5.2 % of CR and 86.8 ± 4.5 % of gross primary production (GPP. Dissolved organic carbon (DOC production peaked in summer and was always positive, with the incubations performed in the dark almost doubling the flux of those performed in the light. Exchangeable dissolved organic carbon (EDOC, however, oscillated between production and uptake, being completely recycled within the system and representing around 14% of the DOC flux. The pools of bottom and surface DOC were high for an oligotrophic environment, and were positively correlated to the pool of EDOC. Thus, despite being in metabolic balance, this ecosystem acted as a conduit for organic carbon (OC, as it is able to export OC to adjacent areas derived from allochtonous inputs during heterotrophic conditions. These inputs likely come from groundwater discharge, human activity in the watershed, delivered to the sediments through the high capacity of C. prolifera to remove particles from the water column, and from the air-water exchange of EDOC, demonstrating that these communities are a major contributor to the cycling of OC in coastal embayments.

  9. Development of an x-ray beam line at the NSLS for studies in materials science using x-ray absorption spectroscopy: Annual progress report

    International Nuclear Information System (INIS)

    Sayers, D.E.

    1986-01-01

    Although only in operation since May, 1985, the X-11 participation research team (PRT) at the NSLS has already demonstrated that it is one of the leading centers of x-ray absorption spectroscopy (XAS). During this time, results have been obtained and programs initiated in a number of areas, for example: interfaces, including deposited metal-metal and metal-semiconductor systems, multilayers and ion implanted layers; electrochemical systems, including Pt electrode fuel cells, Ni oxide battery electrodes, conducting polymers, passivation and corrosion; catalysts, including highly-dispersed supported metal catalysts and zeolite systems; quasi-crystals, heavy fermion systems, uranium and neptunium compounds, rare gas clusters, disordered metals and semiconductors, ferroelectric transition; and, biological systems and related models, including synthetic porphyrins and a number of metalloproteins. In concert with these scientific results have been a number of developments involving the technique itself. These include implementation of unique optical systems on both the A and B lines for optical performance over their designed energy ranges, advances in experimental capability, particular in glancing angle studies, optimization of ion chambers for surface studies, the improvement of electron yield detectors, and improved software for data acquisition and analysis. This report emphasizes some of the research highlights and significant developments of our PRT which occurred during the past year. A detailed bibliography of papers and talks resulting from work done at our beamline and the progress reports for our PRT which were in the 1985 NSLS Annual Report are appended

  10. Annual Progress Report / Continuation Proposal

    Energy Technology Data Exchange (ETDEWEB)

    Brent Fultz

    2001-11-21

    We have been performing basic materials science research on materials for anodes and cathodes in electrochemical cells. The work is a mix of electrochemical measurements and analysis of the materials by transmission electron microscopy and x-ray diffractometry. At present, our experimental work involves only materials for Li storage, but we have been finishing papers from our previous work on hydrogen-storage materials.

  11. Physics department annual progress report

    International Nuclear Information System (INIS)

    Moeller, H.B.; Lebech, B.

    1980-12-01

    Research in the Physics Department at Risoe covers three main fields: solid-state physics, plasma physics, and meteorology. The principal activities in these fields are presented for the period from 1 January to 31 December 1980. (Auth.)

  12. Annual Progress Report of 1982

    International Nuclear Information System (INIS)

    Anon.

    1983-01-01

    The researches programs developed at IEN (Instituto de Engenharia Nuclear) during the year of 1982, are described. Researches are developed in the field of Reactor Physics, Radiation Protection, Chemistry, Nuclear Power Plants, Materials and Metallurgy, Instrumentation and Control. (E.G.) [pt

  13. Annual progress report FY 1975

    International Nuclear Information System (INIS)

    Hansen, K.F.; Henry, A.F.

    1975-04-01

    This project is directed toward development of numerical methods suitable for the computer solution of problems in reactor dynamics and safety. Specific areas of research include methods of integration of the time-dependent diffusion equations by finite difference and finite element methods; representation of reactor properties by various homogenization procedures; application of synthesis methods; and development of response matrix techniques. (14 references) (U.S.)

  14. Physics Department annual progress report

    International Nuclear Information System (INIS)

    Moeller, H.B.; Lebech, B.

    1981-12-01

    Research in the Physics Department at Risoe covers three main fields: solid-state physics; plasma physics; meteorology. The principal activities in these fields are presented in this report, which covers the period from 1 January to 31 December 1981. Introductions to the work in each of the main fields are given in the respective sections of the report. (Auth.)

  15. Association between vitamin D metabolism gene polymorphisms and risk of islet autoimmunity and progression to type 1 diabetes: the diabetes autoimmunity study in the young (DAISY).

    Science.gov (United States)

    Frederiksen, Brittni N; Kroehl, Miranda; Fingerlin, Tasha E; Wong, Randall; Steck, Andrea K; Rewers, Marian; Norris, Jill M

    2013-11-01

    Vitamin D metabolism genes have been associated with type 1 diabetes (T1D) risk; however, these genes have not been investigated for association with the preclinical phase of T1D, islet autoimmunity (IA). Studies of vitamin D metabolism genes may elucidate the role of vitamin D in complex diseases. The objective of the study was to explore the association between seven vitamin D metabolism gene single-nucleotide polymorphisms (SNPs) and the risk of IA and progression to T1D. The Diabetes Autoimmunity Study in the Young is a longitudinal, observational study. Newborn screening for human leukocyte antigen, sibling and offspring recruitment, and follow-up took place in Denver, Colorado. A total of 1708 children at increased genetic risk of T1D participated in the study: 148 developed IA and 62 IA-positive children progressed to T1D. IA, defined as positivity for glutamic acid decarboxylase, insulin, or IA-2 autoantibodies on two or more consecutive visits, and T1D, diagnosed by a physician, were the main outcome measures. The risk of IA was associated with DHCR7/NADSYN1 rs12785878 and CYP27B1 rs4646536 [hazard ratio 1.36, 95% confidence interval 1.08-1.73 (for each additional minor allele) and hazard ratio 0.59, 95% confidence interval 0.39-0.89 (for A/G compared with the A/A genotype), respectively]. None of the vitamin D SNPs typed was associated with progression to T1D in IA-positive children. Six of the seven SNPs were significantly associated with 25-hydroxyvitamin D levels. DHCR7/NADSYN1 rs12785878 and CYP27B1 rs4646536 may play an important role in islet autoimmunity, the preclinical phase of T1D. These findings should be replicated in larger cohorts for confirmation.

  16. Impact of changes in metabolic control on progression to photocoagulation for clinically significant macular oedema:a 20 year study of type 1 diabetes

    DEFF Research Database (Denmark)

    Sander, B.; Larsen, M.; Andersen, Elisabeth Wreford

    2013-01-01

    the effect of changes in glycaemia and arterial blood pressure on the incidence of clinically significant macular oedema in a population of diabetic patients. Methods We performed a retrospective review of all patients with type 1 diabetes who attended the retinopathy screening clinic at the Steno Diabetes......Aims/hypothesis Although increasing hyperglycaemia, arterial hypertension and longer duration of diabetes raise the risk of progression of diabetic retinopathy, short-term benefits in terms of improved metabolic control and lowered blood pressure have not been demonstrated. We therefore examined......-free interval before referral, where the median screening interval was 6 months. Results Risk of progression to photocoagulation for macular oedema increased with duration of diabetes (p 

  17. Effects of aqueous effluents from in situ fossil fuel processing technologies on aquatic systems. Annual progress report, January 1-December 31, 1979

    Energy Technology Data Exchange (ETDEWEB)

    Bergman, H.L.

    1980-01-04

    This is the third annual progress report for a continuing EPA-DOE jointly funded project to evaluate the effects of aqueous effluents from in situ fossil-fuel processing technologies on aquatic biota. The project is organized into four project tasks: (1) literature review; (2) process water screening; (3) methods development; and (4) recommendations. Our Bibliography of aquatic ecosystem effects, analytical methods and treatment technologies for organic compounds in advanced fossil-fuel processing effluents was submitted to the EPA for publication. The bibliography contains 1314 citations indexed by chemicals, keywords, taxa and authors. We estimate that the second bibliography volume will contain approximately 1500 citations and be completed in February. We compiled results from several laboratories of inorganic characterizations of 19 process waters: 55 simulated in situ oil-shale retort waters; and Hanna-3, Hanna-4B 01W and Lawrence Livermore Hoe Creek underground coal gasification condenser waters. These process waters were then compared to a published summary of the analyses from 18 simulated in situ oil-shale retort waters. We completed this year 96-h flow-through toxicity bioassays with fathead minnows and rainbow trout and 48-h flow-through bioassays with Daphnia pulicaria exposed to 5 oil-shale process waters, 1 tar-sand process water, 2 underground coal gasification condenser waters, 1 post-gasification backflood condenser water, as well as 2 bioassays with fossil-fuel process water constituents. The LC/sub 50/ toxicity values for these respective species when exposed to these waters are given in detail. (LTN)

  18. Integrated approach towards the application of horizontal wells to improve waterflooding performance. Annual progress report, January 1, 1996--December 31, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Kelkar, M.; Liner, C.; Kerr, D.

    1997-01-01

    This annual report describes the progress during the fourth year of the project on {open_quotes}Integrated Approach Towards the Application of Horizontal Wells to Improve Waterflooding Performance{close_quotes}. The project involves using an integrated approach to characterize the reservoir followed by proposing an appropriate reservoir management strategy to improve the field performance. In the first stage of the project, the type of data we integrated include cross borehole seismic surveys, geological interpretation based on the logs and the cores, and the engineering information. In contrast, during the second stage of the project, we intend to use only conventional data to construct the reservoir description. This report covers the results of the implementation from the first stage of the project. It also discusses the work accomplished so far for the second stage of the project. The production from the Self Unit (location of Stage 1) has sustained an increase of 30 bbls/day over a year with an additional increase anticipated with further implementation. We have collected available core, log and production data from Section 16 in the Berryhill Glenn Unit and have finished the geological description. Based on the geological description and the associated petrophysical properties, we have developed a new indexing procedure for identifying the areas with the most potential. We are also investigating an adjoining tract formerly operated by Chevron where successful miceller-polymer flood was conducted. This will help us in evaluating the reasons for the success of the flood. Armed with this information, we will conduct a detailed geostatistical and flow simulation study and recommend the best reservoir management plan to improve the recovery of the field.

  19. Lipidomics to analyze the influence of diets with different EPA:DHA ratios in the progression of Metabolic Syndrome using SHROB rats as a model.

    Science.gov (United States)

    Dasilva, Gabriel; Pazos, Manuel; García-Egido, Eduardo; Pérez-Jiménez, Jara; Torres, Josep Lluis; Giralt, Montserrat; Nogués, María-Rosa; Medina, Isabel

    2016-08-15

    The role of specific proportions of ω-3 EPA and DHA, in the modulation of inflammation and oxidative stress markers associated to the progression of Metabolic Syndrome was investigated. Potential inflammatory eicosanoids and docosanoids were discussed together to biomarkers of CVD, obesity, inflammation and oxidative stress in an animal model of metabolic disorders. Results evidenced a noteworthy health effect of 1:1 and 2:1 EPA:DHA proportions over 1:2 EPA:DHA based diets through a down-regulation in the production of strong pro-inflammatory ω-6 eicosanoids, a decrement of biomarkers of oxidative stress, and a modulation of fatty acid desaturase activities and plasma and membrane PUFAs towards greater anti-inflammatory profiles. Outcomes contribute to the general knowledge on the health benefits of marine lipids and their role on the progress of MetS, inflammation and oxidative stress. Results shed light on controversial protective mechanisms of EPA and DHA to better design dietary interventions aimed at reducing MetS. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Brain Dopamine Transporter Binding and Glucose Metabolism in Progressive Supranuclear Palsy-Like Creutzfeldt-Jakob Disease

    Directory of Open Access Journals (Sweden)

    Eero Rissanen

    2014-01-01

    Full Text Available Here, we present a patient with Creutzfeldt-Jakob disease (CJD who developed initial symptoms mimicking progressive supranuclear palsy (PSP. Before the development of typical CJD symptoms, functional imaging supported a diagnosis of PSP when [123I]-FP-CIT-SPECT showed a defect in striatal dopamine transporter binding, while [18F]-fluorodeoxyglucose PET showed cortical hypometabolism suggestive of Lewy body dementia. However, the postmortem neuropathological examination was indicative of CJD only, without tau protein or Lewy body findings. This case demonstrates that CJD should be taken into account in rapidly progressing atypical cases of parkinsonism, even when functional imaging supports a diagnosis of a movement disorder.

  1. Neuron-glia crosstalk in the autonomic nervous system and its possible role in the progression of metabolic syndrome: A new hypothesis

    Directory of Open Access Journals (Sweden)

    RODRIGO eDEL RIO

    2015-12-01

    Full Text Available Metabolic syndrome (MS is characterized by the following physiological alterations: increase in abdominal fat, insulin resistance, high concentration of triglycerides, low levels of HDL, high blood pressure and a generalized inflammatory state. One of the pathophysiological hallmarks of this syndrome is the presence of neurohumoral activation, which involve autonomic imbalance associated to hyperactivation of the sympathetic nervous system. Indeed, enhanced sympathetic drive has been linked to the development of endothelial dysfunction, hypertension, stroke, myocardial infarct and obstructive sleep apnea. Glial cells, the most abundant cells in the central nervous system, control synaptic transmission and regulate neuronal function by releasing bioactive molecules called gliotransmitters. Recently, a new family of plasma membrane channels called hemichannels has been described to allow the release of gliotransmitters and modulate neuronal firing rate. Moreover, a growing amount of evidence indicates that uncontrolled hemichannel opening could impair glial cell functions, affecting synaptic transmission and neuronal survival. Given that glial cell functions are disturbed in various metabolic diseases, we hypothesize that progression of MS may relies on hemichannel-dependent impairment of glial-to-neuron communication by a mechanism related to dysfunction of inflammatory response and mitochondrial metabolism of glial cells. In this manuscript, we discuss how glial cells may contribute to the enhanced sympathetic drive observed in MS, and shed light about the possible role of hemichannels in this process.

  2. Neuron-Glia Crosstalk in the Autonomic Nervous System and Its Possible Role in the Progression of Metabolic Syndrome: A New Hypothesis.

    Science.gov (United States)

    Del Rio, Rodrigo; Quintanilla, Rodrigo A; Orellana, Juan A; Retamal, Mauricio A

    2015-01-01

    Metabolic syndrome (MS) is characterized by the following physiological alterations: increase in abdominal fat, insulin resistance, high concentration of triglycerides, low levels of HDL, high blood pressure, and a generalized inflammatory state. One of the pathophysiological hallmarks of this syndrome is the presence of neurohumoral activation, which involve autonomic imbalance associated to hyperactivation of the sympathetic nervous system. Indeed, enhanced sympathetic drive has been linked to the development of endothelial dysfunction, hypertension, stroke, myocardial infarct, and obstructive sleep apnea. Glial cells, the most abundant cells in the central nervous system, control synaptic transmission, and regulate neuronal function by releasing bioactive molecules called gliotransmitters. Recently, a new family of plasma membrane channels called hemichannels has been described to allow the release of gliotransmitters and modulate neuronal firing rate. Moreover, a growing amount of evidence indicates that uncontrolled hemichannel opening could impair glial cell functions, affecting synaptic transmission and neuronal survival. Given that glial cell functions are disturbed in various metabolic diseases, we hypothesize that progression of MS may relies on hemichannel-dependent impairment of glial-to-neuron communication by a mechanism related to dysfunction of inflammatory response and mitochondrial metabolism of glial cells. In this manuscript, we discuss how glial cells may contribute to the enhanced sympathetic drive observed in MS, and shed light about the possible role of hemichannels in this process.

  3. Photons, photosynthesis, and high-performance computing: challenges, progress, and promise of modeling metabolism in green algae

    International Nuclear Information System (INIS)

    Chang, C H; Graf, P; Alber, D M; Kim, K; Murray, G; Posewitz, M; Seibert, M

    2008-01-01

    The complexity associated with biological metabolism considered at a kinetic level presents a challenge to quantitative modeling. In particular, the relatively sparse knowledge of parameters for enzymes with known kinetic responses is problematic. The possible space of these parameters is of high-dimension, and sampling of such a space typifies a combinatorial explosion of possible dynamic states. However, with sufficient quantitative transcriptomics, proteomics, and metabolomics data at hand, these challenges could be met by high-performance software with sampling, fitting, and optimization capabilities. With this in mind, we present the High-Performance Systems Biology Toolkit HiPer SBTK, an evolving software package to simulate, fit, and optimize metabolite concentrations and fluxes within the space of rate and binding parameters associated with detailed enzyme kinetic models. We present our chosen modeling paradigm for the formulation of metabolic pathway models, the means to address the challenge of representing such models in a precise and persistent fashion using the standardized Systems Biology Markup Language, and our second-generation model of H2-associated Chlamydomonas metabolism. Processing of such models for hierarchically parallelized simulation and optimization, job specification by the user through a GUI interface, software capabilities and initial scaling data, and the mapping of the computation to biological questions is also discussed. Moreover, we present near-term future software and model development goals

  4. IKO Annual Report 1976

    International Nuclear Information System (INIS)

    1977-01-01

    The IKO Annual Report of 1976 relates their progress in different projects and project fields. The fields covered include electron scattering, pion and muon physics, theory, radio- and nuclear chemistry, technical department, MEA, nuclear reactions and nuclear spectroscopy

  5. Effect of rimonabant on carotid intima-media thickness (CIMT) progression in patients with abdominal obesity and metabolic syndrome: the AUDITOR Trial.

    Science.gov (United States)

    O'Leary, Daniel H; Reuwer, Anne Q; Nissen, Steven E; Després, Jean-Pierre; Deanfield, John E; Brown, Michael W; Zhou, Rong; Zabbatino, Salvatore M; Job, Bernard; Kastelein, John J P; Visseren, Frank L J

    2011-07-01

    The aim of this trial was to determine whether obese patients benefit from treatment with rimonabant in terms of progression of carotid atherosclerosis. Rimonabant, a selective cannabinoid-1 receptor blocker, reduces body weight and improves cardiometabolic risk factors in patients who are obese. A prospective, double-blind, placebo-controlled trial (Atherosclerosis Underlying Development assessed by Intima-media Thickness in patients On Rimonabant (AUDITOR)) randomised 661 patients with abdominal obesity and metabolic syndrome to rimonabant or placebo for 30 months of treatment. The absolute change in the average value for six segments of far wall carotid intima-media thickness from baseline to month 30 was 0.010 ± 0.095 mm in the rimonabant group and 0.012 ± 0.091 mm in the placebo group (p=0.67). The annualised change was an increase of 0.005 ± 0.042 mm for the rimonabant-treated group and 0.007 ± 0.043 mm for the placebo-treated group (p=0.45). There was no difference in atherosclerosis progression between patients receiving rimonabant for 30 months and those receiving placebo for the primary efficacy measure (absolute change in carotid intima-media thickness). These findings are consistent with a similar study using coronary intravascular ultrasound and another study evaluating the occurrence of cardiovascular events. Our findings suggest that a 5% loss of body weight over a 30-month period with rimonabant is insufficient to modify atherosclerosis progression in the carotid artery in obese patients with metabolic syndrome. Clinical trial registration information clinicaltrials.gov Identifier: NCT00228176.

  6. SciDAC's Earth System Grid Center for Enabling Technologies Semi-Annual Progress Report for the Period April 1, 2009 through September 30, 2009

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Dean N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Foster, I. T. [Argonne National Lab. (ANL), Argonne, IL (United States); Middleton, D. E. [National Center for Atmospheric Research (NCAR), Boulder, CO (United States)

    2009-10-15

    This report summarizes work carried out by the ESG-CET during the period April 1, 2009 through September 30, 2009. It includes discussion of highlights, overall progress, period goals, collaborations, papers, and presentations. To learn more about our project, and to find previous reports, please visit the Earth System Grid Center for Enabling Technologies (ESG-CET) website. This report will be forwarded to the DOE SciDAC program management, the Office of Biological and Environmental Research (OBER) program management, national and international collaborators and stakeholders (e.g., the Community Climate System Model (CCSM), the Intergovernmental Panel on Climate Change (IPCC) 5th Assessment Report (AR5), the Climate Science Computational End Station (CCES), the SciDAC II: A Scalable and Extensible Earth System Model for Climate Change Science, the North American Regional Climate Change Assessment Program (NARCCAP), and other wide-ranging climate model evaluation activities). During this semi-annual reporting period, the ESG-CET team continued its efforts to complete software components needed for the ESG Gateway and Data Node. These components include: Data Versioning, Data Replication, DataMover-Lite (DML) and Bulk Data Mover (BDM), Metrics, Product Services, and Security, all joining together to form ESG-CET's first beta release. The launch of the beta release is scheduled for late October with the installation of ESG Gateways at NCAR and LLNL/PCMDI. Using the developed ESG Data Publisher, the ESG II CMIP3 (IPCC AR4) data holdings - approximately 35 TB - will be among the first datasets to be published into the new ESG enterprise system. In addition, the NCAR's ESG II data holdings will also be published into the new system - approximately 200 TB. This period also saw the testing of the ESG Data Node at various collaboration sites, including: the British Atmospheric Data Center (BADC), the Max-Planck-Institute for Meteorology, the University of Tokyo

  7. Summer investigations into the metabolic diversity of the microbial world. Progress report, May 5, 1992--April 30, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Breznak, J.; Dworkin, M.

    1993-05-17

    The philosophy of the course described here is to underscore the essence of microbiology which is diversity>: diversity of morphology and cellular development, behavior, and metabolic and physiological functions. Emphasis is on microbes other than those customarily covered in conventional microbiology courses and includes: the archaebacteria, extremophiles, and array of obligate anaerobes, various phototrophs, and those microbes exhibiting complex developmental cycles. Also included are microbes carrying out a variety of transformations of organic and inorganic compounds, as well as those which normally occur in symbiotic association with other microbes or with higher forms of life.

  8. Missouri local technical assistance program at Missouri University of Science and Technology (formerly University of Missouri--Rolla) : annual progress report January-December 2007.

    Science.gov (United States)

    2009-02-01

    This annual report is a summary of the activities during 2007 for the Missouri Local Technical Assistance Program (Missouri LTAP), which is located at Missouri University of Science and Technology. The report highlights Missouri LTAPs performance ...

  9. Relationship of metabolic syndrome with incident aortic valve calcium and aortic valve calcium progression: the Multi-Ethnic Study of Atherosclerosis (MESA).

    Science.gov (United States)

    Katz, Ronit; Budoff, Matthew J; Takasu, Junichiro; Shavelle, David M; Bertoni, Alain; Blumenthal, Roger S; Ouyang, Pamela; Wong, Nathan D; O'Brien, Kevin D

    2009-04-01

    Metabolic syndrome (MetS) has been associated with increased prevalence of aortic valve calcium (AVC) and with increased progression of aortic stenosis. The purpose of this study was to determine whether MetS is associated with increased risks for the development of new ("incident") AVC or for progression of established AVC as assessed by CT. The relationships of MetS or its components as well as of diabetes to risks for incident AVC or AVC progression were studied among participants with CT scans performed at baseline and at either year 2 or year 3 examinations in the Multi-Ethnic Study of Atherosclerosis (MESA). Of 5,723 MESA participants meeting criteria for inclusion, 1,674 had MetS by Adult Treatment Panel III criteria, whereas 761 had diabetes. Among the 5,123 participants without baseline AVC, risks for incident AVC, adjusted for time between scans, age, sex, race/ethnicity, LDL cholesterol, lipid-lowering medications, and smoking, were increased significantly for MetS (odds ratio [OR] 1.67 [95% CI 1.21-2.31]) or diabetes (2.06 [1.39-3.06]). In addition, there was an increase in incident AVC risk with increasing number of MetS components. Similar results were found using the International Diabetes Federation MetS criteria. Among the 600 participants (10.5%) with baseline AVC, neither MetS nor diabetes was associated with AVC progression. In the MESA cohort, MetS was associated with a significant increase in incident ("new") AVC, raising the possibility that MetS may be a potential therapeutic target to prevent AVC development.

  10. Genetic and metabolic signals during acute enteric bacterial infection alter the microbiota and drive progression to chronic inflammatory disease

    Energy Technology Data Exchange (ETDEWEB)

    Kamdar, Karishma; Khakpour, Samira; Chen, Jingyu; Leone, Vanessa; Brulc, Jennifer; Mangatu, Thomas; Antonopoulos, Dionysios A.; Chang, Eugene B; Kahn, Stacy A.; Kirschner, Barbara S; Young, Glenn; DePaolo, R. William

    2016-01-13

    Chronic inflammatory disorders are thought to arise due to an interplay between predisposing host genetics and environmental factors. For example, the onset of inflammatory bowel disease is associated with enteric proteobacterial infection, yet the mechanistic basis for this association is unclear. We have shown previously that genetic defiency in TLR1 promotes acute enteric infection by the proteobacteria Yersinia enterocolitica. Examining that model further, we uncovered an altered cellular immune response that promotes the recruitment of neutrophils which in turn increases metabolism of the respiratory electron acceptor tetrathionate by Yersinia. These events drive permanent alterations in anti-commensal immunity, microbiota composition, and chronic inflammation, which persist long after Yersinia clearence. Deletion of the bacterial genes involved in tetrathionate respiration or treatment using targeted probiotics could prevent microbiota alterations and inflammation. Thus, acute infection can drive long term immune and microbiota alterations leading to chronic inflammatory disease in genetically predisposed individuals.

  11. Impact of Gentamicin Coadministration along with High Fructose Feeding on Progression of Renal Failure and Metabolic Syndrome in Sprague-Dawley Rats

    Directory of Open Access Journals (Sweden)

    Zaid O. Ibraheem

    2014-01-01

    Full Text Available The current study evaluates the impact of high fructose feeding in rat model of gentamicin induced nephrotoxicity. Sprague-Dawley rats weighing 180–200 g were randomized into four groups; (C received standard rodents chow with free access to ad libitum drinking water for 8 weeks and was considered as control, (F received standard rodents chow with free access to drinking water supplemented with 20% (W/V fructose for the same abovementioned period, (FG was fed as group F and was given 80 mg/kg (body weight/day gentamicin sulphate intraperitoneally during the last 20 days of the feeding period, and (G was given gentamicin as above and fed as group C. Renal function was assessed at the end of the treatment period through measuring serum creatinine, uric acid and albumin, creatinine clearance, absolute and fractional excretion of both sodium and potassium, twenty-four-hour urinary excretion of albumin, and renal histology. For metabolic syndrome assessment, fasting plasma glucose and insulin were measured and oral glucose tolerance test was performed throughout the treatment period. Results showed that gentamicin enhances progression of fructose induced metabolic syndrome. On the other hand, fructose pretreatment before gentamicin injection produced a comparable degree of renal dysfunction to those which were given fructose-free water but the picture of nephrotoxicity was somewhat altered as it was characterized by higher extent of glomerular congestion and protein urea. Overall, more vigilance is required when nephrotoxic drugs are prescribed for patients with fructose induced metabolic syndrome.

  12. The Role of Sarcosine, Uracil, and Kynurenic Acid Metabolism in Urine for Diagnosis and Progression Monitoring of Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Georgios Gkotsos

    2017-02-01

    Full Text Available The aim of this pilot study is to evaluate sarcosine, uracil, and kynurenic acid in urine as potential biomarkers in prostate cancer detection and progression monitoring. Sarcosine, uracil, and kynurenic acid were measured in urine samples of 32 prostate cancer patients prior to radical prostatectomy, 101 patients with increased prostate-specific antigen prior to ultrasonographically-guided prostatic biopsy collected before and after prostatic massage, and 15 healthy volunteers (controls. The results were related to histopathologic data, Gleason score, and PSA (Prostate Specific Antigen. Metabolites were measured after analysis of urine samples with Ultra-High Performance Liquid Chromatography coupled to tandem mass spectrometry (UPLC-MS/MS instrumentation. Multivariate, nonparametric statistical tests including receiver operating characteristics analyses, one-way analysis of variance (Kruskal–Wallis test, parametric statistical analysis, and Pearson correlation, were performed to evaluate diagnostic performance. Decreased median sarcosine and kynurenic acid and increased uracil concentrations were observed for patients with prostate cancer compared to participants without malignancy. Results showed that there was no correlation between the concentration of the studied metabolites and the cancer grade (Gleason score <7 vs. ≥7 and the age of the patients. Evaluation of biomarkers by ROC (Receiving Operating Characteristics curve analysis showed that differentiation of prostate cancer patients from participants without malignancy was not enhanced by sarcosine or uracil levels in urine. In contrast to total PSA values, kynurenic acid was found a promising biomarker for the detection of prostate cancer particularly in cases where collection of urine samples was performed after prostatic massage. Sarcosine and uracil in urine samples of patients with prostate cancer were not found as significant biomarkers for the diagnosis of prostate cancer

  13. Toxicology and metabolism of nickel compounds. Progress report, December 1, 1978-November 30, 1979. [Hamsters and rats

    Energy Technology Data Exchange (ETDEWEB)

    Sunderman, F.W. Jr.

    1979-08-15

    The toxicology and metabolism of nickel compounds were investigated in rats and hamsters. The new knowledge includes; demonstration that nickel carbonyl is teratogenic for hamsters; elucidation of physiological factors which influence ..cap alpha..Ni/sub 3/S/sub 2/-induced erythrocytosis in rats; development of a sensitive assay for heme oxygenase activity in renal microsomes for use in studies of renal effects of nickel compounds; demonstration that administration of Ni(CO)/sub 4/ to rats inhibits incorporation of /sup 3/H-thymidine into DNA during hepatic regeneration; demonstration that clones of Syrian hamster fetal cells which have been transformed by in vitro exposure to ..cap alpha..Ni/sub 3/S/sub 2/ consistently cause sarcomas following sc injection into nude mice; demonstration that nickel carbonyl-cyclopentadiene dimer induces rhabdomyosarcomas following im injection in rats; observation of differences in carcinogenic activities of several insoluble nickel compounds; discovery that intraocular injection of ..cap alpha..Ni/sub 3/S/sub 2/ induces amelanotic melanomas in rats; and refinement of analytical methods for nickel in biological materials.

  14. Toxicology and metabolism of nickel compounds. Progress report, December 1, 1975--November 30, 1976. [Tests made with rats and hamsters

    Energy Technology Data Exchange (ETDEWEB)

    Sunderman, F.W. Jr.

    1976-08-15

    The toxicology and metabolism of nickel compounds (NiCl/sub 2/, Ni/sub 3/S/sub 2/, NiS, Ni powder, and Ni(CO)/sub 4/) were investigated in rats and hamsters. Triethylenetetramine (TETA) and d-penicillamine are more effective than other chelating agents (Na-diethyldithiocarbamate, CaNa/sub 2/-versenate, diglycylhistidine-N-methylamide and ..cap alpha..-lipoic acid) as antidotes for acute Ni(II)-toxicity in rats. The antidotal efficacy of triethylenetetramine (TETA) in acute Ni(II)-toxicity is mediated by rapid reduction of the plasma concentration of Ni(II), consistent with renal clearance of the TETA-Ni complex at a rate more than twenty times greater than the renal clearance of non-chelated Ni(II). Fischer rats are more susceptible than other rat strains (Wistar-Lewis, Long-Evans and NIH-Black) to induction of erythrocytosis after an intrarenal injection of Ni/sub 3/S/sub 2/, and elucidation of the serial pathologic changes that occur in rats after an intrarenal injection of Ni/sub 3/S/sub 2/. When amorphous nickel monosulfide (NiS) and nickel subsulfide (Ni/sub 3/S/sub 2/) were administered by im injection to randomly selected Fischer rats in equivalent amounts under identical conditions, NiS did not induce any tumors whereas Ni/sub 3/S/sub 2/ induced sarcomas in almost all of the rats.

  15. Gas-Cooled Reactor Programs. High-Temperature Gas-Cooled Reactor Base-Technology Program. Annual progress report for period ending December 31, 1977

    Energy Technology Data Exchange (ETDEWEB)

    Homan, F.J.; Kasten, P.R.

    1978-07-01

    Progress in HTGR studies is reported in the following areas: fission product technology and coolant impurity effects, fueled graphite development, PCRV development, structural materials, characterization and standardization of graphite, and evaluation of the pebble-bed type HTR.

  16. Gas-cooled reactor programs: High-Temperature Gas-Cooled Reactor Base-Technology Program. Annual progress report for period ending December 31, 1979

    Energy Technology Data Exchange (ETDEWEB)

    1980-07-01

    Progress in HTGR studies is reported in the following areas: HTGR chemistry; fueled graphite development; prestressed concrete pressure vessel development; structural materials; HTGR graphite studies; and evaluation of the pebble-bed HTR.

  17. Relationship between Metabolic Syndrome and Predictors for Clinical Benign Prostatic Hyperplasia Progression and International Prostate Symptom Score in Patients with Moderate to Severe Lower Urinary Tract Symptoms.

    Science.gov (United States)

    Zhao, Sicong; Chen, Chao; Chen, Zongping; Xia, Ming; Tang, Jianchun; Shao, Sujun; Yan, Yong

    2016-06-28

    To investigate the association between metabolic syndrome (MetS) and the predictors of the progression of benign prostatic hyperplasia (BPH) and the corresponding frequency and severity of lower urinary tract symptoms (LUTS). A total of 530 men with moderate to severe International Prostate Symptom Score (IPSS) > 7 were recruited in the present study. The predictors for clinical BPH progression were defined as the total prostate volume (TPV) ≥ 31 cm3, prostate-specific antigen level (PSA) ≥ 1.6 ng/mL, maximal flow rate (Qmax) < 10.6 mL/s, postvoid residual urine volume (PVR) of ≥ 39 mL, and age 62 years or older. LUTS were defined according to the IPSS and MetS with the National Cholesterol Education Program-Adult Treatment Panel III guidelines. The Mantel-Haenszel extension test and the multivariate logistic regression analyses were used to statistically examine their relationships. The percentage of subjects with ≥ 1 predictors for clinical BPH progression, the percentage of subjects with a TPV ≥ 31 cm3, the percentage of subjects with a PVR ≥ 39 mL, and the percentage of subjects with a Qmax < 10.6 mL/s increased significantly with the increasing in the number of MetS components (all P < .05). After adjusting for age and serum testosterone level, the MetS were independently associated with the presence of TPV ≥ 31 cm3 (OR = 17.030, 95% CI: 7.495-38.692). Moreover, MetS was positively associated with the severity of LUTS (P < .001) and voiding scores (P < .001), and each individual MetS component appeared as an independent risk factor for severe LUTS (IPSS > 19, all P < .001). Our data have shown that the MetS significantly associated with the predictors for clinical BPH progression and the frequency and severity of LUTS, especially the voiding symptoms. The prevention of such modifiable factors by promotion of dietary changes and regular physical activity practice may be of great importance for public health. .

  18. Effects of the Operation of Hungry Horse Dam on the Kokanee Fishery in the Flathead River System, 1983 Annual Progress Report.

    Energy Technology Data Exchange (ETDEWEB)

    Fraley, John J.

    1983-11-01

    This study was undertaken to assess the effects of the operation of Hungry Horse Dam on the kokanee fishery in the Flathead River system. This annual report covers the 1982-1983 field season concerning the effects of Hungry Horse operations on kokanee abundance, migration, spawning, egg incubation and fry emergence in the Flathead River system. This report also addresses the expected recovery of the mainstem kokanee population under the flow regime recommended by the Department of Fish, Wildlife and Parks in 1982.

  19. Daily physical-rest activities in relation to nutritional state, metabolism, and quality of life in cancer patients with progressive cachexia.

    Science.gov (United States)

    Fouladiun, Marita; Körner, Ulla; Gunnebo, Lena; Sixt-Ammilon, Petra; Bosaeus, Ingvar; Lundholm, Kent

    2007-11-01

    To evaluate daily physical-rest activities in cancer patients losing weight in relation to disease progression. Physical activity-rest rhythms were measured (ActiGraph, armband sensor from BodyMedia) in relation to body composition (dual-energy X-ray absorptiometry), energy metabolism, exercise capacity (walking test), and self-scored quality of life (SF-36, Hospital Anxiety and Depression Scale) in weight-losing outpatients with systemic cancer (71 +/- 2 years, n = 53). Well-nourished, age-matched, and previously hospitalized non-cancer patients served as controls (74 +/- 4 years, n = 8). Middle-aged healthy individuals were used as reference subjects (49 +/- 5 years, n = 23). Quality of life was globally reduced in patients with cancer (P sleep and bed-rest activities did not differ between patients with cancer and age-matched non-cancer patients. Spontaneous physical activity correlated weakly with maximum exercise capacity in univariate analysis (r = 0.41, P < 0.01). Multivariate analysis showed that spontaneous physical activity was related to weight loss, blood hemoglobin concentration, C-reactive protein, and to subjectively scored items of physical functioning and bodily pain (SF-36; P < 0.05-0.004). Anxiety and depression were not related to spontaneous physical activity. Patient survival was predicted only by weight loss and serum albumin levels (P < 0.01), although there was no such prediction for spontaneous physical activity. Daily physical-rest activities represent variables which probably reflect complex mental physiologic and metabolic interactions. Thus, activity-rest monitoring provides a new dimension in the evaluation of medical and drug interventions during palliative treatment of patients with cancer.

  20. Combination of baseline metabolic tumour volume and early response on PET/CT improves progression-free survival prediction in DLBCL

    Energy Technology Data Exchange (ETDEWEB)

    Mikhaeel, N.G.; Smith, Daniel [Guy' s and St Thomas' NHS Foundation Trust, Department of Clinical Oncology, London (United Kingdom); Dunn, Joel T.; Phillips, Michael; Barrington, Sally F. [King' s College London, PET Imaging Centre at St Thomas' Hospital, Division of Imaging Sciences and Biomedical Engineering, London (United Kingdom); Moeller, Henrik [King' s College London, Department of Cancer Epidemiology and Population Health, London (United Kingdom); Fields, Paul A.; Wrench, David [Guy' s and St Thomas' NHS Foundation Trust, Department of Haematology, London (United Kingdom)

    2016-07-15

    The study objectives were to assess the prognostic value of quantitative PET and to test whether combining baseline metabolic tumour burden with early PET response could improve predictive power in DLBCL. A total of 147 patients with DLBCL underwent FDG-PET/CT scans before and after two cycles of RCHOP. Quantitative parameters including metabolic tumour volume (MTV) and total lesion glycolysis (TLG) were measured, as well as the percentage change in these parameters. Cox regression analysis was used to test the relationship between progression-free survival (PFS) and the study variables. Receiver operator characteristics (ROC) analysis determined the optimal cut-off for quantitative variables, and Kaplan-Meier survival analysis was performed. The median follow-up was 3.8 years. As MTV and TLG measures correlated strongly, only MTV measures were used for multivariate analysis (MVA). Baseline MTV (MTV-0) was the only statistically significant predictor of PFS on MVA. The optimal cut-off for MTV-0 was 396 cm{sup 3}. A model combing MTV-0 and Deauville score (DS) separated the population into three distinct prognostic groups: good (MTV-0 < 400; 5-year PFS > 90 %), intermediate (MTV-0 ≥ 400+ DS1-3; 5-year PFS 58.5 %) and poor (MTV-0 ≥ 400+ DS4-5; 5-year PFS 29.7 %) MTV-0 is an important prognostic factor in DLBCL. Combining MTV-0 and early PET/CT response improves the predictive power of interim PET and defines a poor-prognosis group in whom most of the events occur. (orig.)